WorldWideScience

Sample records for non-slurry approach progress

  1. Understanding Progress: A Heterodox Approach

    Directory of Open Access Journals (Sweden)

    Blanca Lemus

    2013-01-01

    Full Text Available This paper examines the possibility of understanding and measuring well-being as a result of “progress” on the basis of today’s dominant epistemological framework. Market criteria distort social values by allowing purchasing power to define priorities, likening luxury goods to basic needs; in the process they reinforce patterns of discrimination against disadvantaged social groups and women, introducing fatal distortions into the analysis. Similarly, because there are no appropriate mechanisms to price natural resources adequately, the market overlooks the consequences of the abuse of natural resources, degrading the quality of life, individually and collectively, or—in the framework of Latin American indigenous groups—foreclosing the possibility of “living well”. We critique the common vision of the official development discourse that places its faith on technological innovations to resolve these problems. The analysis points to the need for new models of social and environmental governance to promote progress, approaches like those suggested in the paper that are inconsistent with public policies currently in place. At present, the social groups forging institutions to assure their own well-being and ecological balance are involved in local processes, often in opposition to the proposals of the political leaders in their countries.

  2. A Progressive Approach to Content Generation

    DEFF Research Database (Denmark)

    Shaker, Mohammad; Shaker, Noor; Togelius, Julian

    2015-01-01

    and the associated level design. The framework first generates timelines following the search-based paradigm. Timelines are game-independent and they reflect the rhythmic feel of the levels. A progressive, constructive-based approach is then implemented to evaluate timelines by mapping them into level designs...

  3. Women and social security: a progressive approach.

    Science.gov (United States)

    Olson, L K

    1994-01-01

    This article explores some major assumptions underlying the Social Security system and alternative approaches to rendering the system more economically viable, meeting the income needs of the elderly and/or providing greater equity under its benefit and taxation provisions. It attempts to show that the current structure of Social Security not only reinforces but also exacerbates the underlying economic inequalities in our nation's political economy under the guise of a social insurance program. In addressing selected benefit and taxation issues, the article focuses on how working and older women are faring in the 1990s under the Social Security system. It argues that although the program theoretically is gender neutral, its impact is not. Women, particularly those who are single, are poorly served. The article concludes that a progressive restructuring of the Social Security system itself is imperative if we are to meet the needs of a large percentage of workers, older people, and the economic and social demands of the 1990s and beyond. It also offers some suggestions for such change.

  4. A progressive approach to discrete trial teaching: Some current guidelines

    Directory of Open Access Journals (Sweden)

    Justin B. Leaf

    2016-12-01

    Full Text Available Discrete trial teaching (DTT is one of the cornerstones of applied behavior analysis (ABA based interventions. Conventionally, DTT is commonly implemented within a prescribed, fixed manner in which the therapist is governed by a strict set of rules. In contrast to conventional DTT, a progressive approach to DTT allows the therapist to remain flexible, making in-the-moment analyses and changes based on several variables (e.g., individual responding, current and previous history. The present paper will describe some guidelines to a progressive approach to DTT. The guidelines presented here should not be taken as a set of rules or as an exhaustive list.

  5. A Progressive Approach to Discrete Trial Teaching: Some Current Guidelines

    Directory of Open Access Journals (Sweden)

    Justin B. LEAF

    2016-12-01

    Full Text Available Discrete trial teaching (DTT is one of the cornerstones of applied behavior analysis (ABA based interventions. Conventionally, DTT is commonly implemented within a prescribed, fixed manner in which the therapist is governed by a strict set of rules. In contrast to conventional DTT, a progressive approach to DTT allows the therapist to remain flexible, making in-the-moment analyses and changes based on several variables (e.g., individual responding, current and previous history. The present paper will describe some guidelines to a progressive approach to DTT. The guidelines presented here should not be taken as a set of rules or as an exhaustive list.

  6. A Progressive Approach to Discrete Trial Teaching: Some Current Guidelines

    Science.gov (United States)

    Leaf, Justin B.; Cihon, Joseph H.; Leaf, Ronald; McEachin, John; Taubman, Mitchell

    2016-01-01

    Discrete trial teaching (DTT) is one of the cornerstones of applied behavior analysis (ABA) based interventions. Conventionally, DTT is commonly implemented within a prescribed, fixed manner in which the therapist is governed by a strict set of rules. In contrast to conventional DTT, a progressive approach to DTT allows the therapist to remain…

  7. Progressive delamination in polymer matrix composite laminates: A new approach

    Science.gov (United States)

    Chamis, C. C.; Murthy, P. L. N.; Minnetyan, L.

    1992-01-01

    A new approach independent of stress intensity factors and fracture toughness parameters has been developed and is described for the computational simulation of progressive delamination in polymer matrix composite laminates. The damage stages are quantified based on physics via composite mechanics while the degradation of the laminate behavior is quantified via the finite element method. The approach accounts for all types of composite behavior, laminate configuration, load conditions, and delamination processes starting from damage initiation, to unstable propagation, and to laminate fracture. Results of laminate fracture in composite beams, panels, plates, and shells are presented to demonstrate the effectiveness and versatility of this new approach.

  8. Progressive fracture of polymer matrix composite structures: A new approach

    Science.gov (United States)

    Chamis, C. C.; Murthy, P. L. N.; Minnetyan, L.

    1992-01-01

    A new approach independent of stress intensity factors and fracture toughness parameters has been developed and is described for the computational simulation of progressive fracture of polymer matrix composite structures. The damage stages are quantified based on physics via composite mechanics while the degradation of the structural behavior is quantified via the finite element method. The approach account for all types of composite behavior, structures, load conditions, and fracture processes starting from damage initiation, to unstable propagation and to global structural collapse. Results of structural fracture in composite beams, panels, plates, and shells are presented to demonstrate the effectiveness and versatility of this new approach. Parameters and guidelines are identified which can be used as criteria for structural fracture, inspection intervals, and retirement for cause. Generalization to structures made of monolithic metallic materials are outlined and lessons learned in undertaking the development of new approaches, in general, are summarized.

  9. Exploring the Climate Literacy Development Utilizing a Learning Progressions Approach

    Science.gov (United States)

    Drewes, A.; Breslyn, W.; McGinnis, J. R.; Hestness, E.; Mouza, C.

    2017-12-01

    Climate change encompasses a broad and complex set of concepts that is often challenging for students and educators. Using a learning progressions framework, in this exploratory study we report our efforts to identify, describe, and organize the development of learners' understanding of climate change in an empirically supported learning progression (LP). The learning progression framework is a well suited analytical tool for investigating how student thinking develops over time (Duschl et al., 2007). Our primary research question is "How do learners progress over time from an initial to a more sophisticated understanding of climate change?"We followed a development process that involved drafting a hypothetical learning progression based on the science education research literature, consensus documents such as the Next Generation Science Standards and the Atlas of Science Literacy. Additionally, we conducted expert reviews with both climate scientists and educational researchers on the content and pedagogical expectations. Data are then collected from learners, which are used to modify the hypothetical learning progression based on how well it describes actual student learning. In this current analysis, we present findings from written assessments (N=294) and in-depth interviews (n=27) with middle school students in which we examine their understanding of the role of human activity, the greenhouse effect as the mechanism of climate change, local and global impacts, and strategies for the adaptation and mitigation of climate change. The culmination of our research is a proposed, empirically supported LP for climate change. Our LP is framed by consideration of four primary constructs: Human Activity, Mechanism, Impacts, and Mitigation and Adaptation. The conditional LP provides a solid foundation for continued research as well as providing urgently needed guidance to the education community on climate change education (for curriculum, instruction, and assessment

  10. Progress and challenges in bioinformatics approaches for enhancer identification

    KAUST Repository

    Kleftogiannis, Dimitrios A.

    2017-02-03

    Enhancers are cis-acting DNA elements that play critical roles in distal regulation of gene expression. Identifying enhancers is an important step for understanding distinct gene expression programs that may reflect normal and pathogenic cellular conditions. Experimental identification of enhancers is constrained by the set of conditions used in the experiment. This requires multiple experiments to identify enhancers, as they can be active under specific cellular conditions but not in different cell types/tissues or cellular states. This has opened prospects for computational prediction methods that can be used for high-throughput identification of putative enhancers to complement experimental approaches. Potential functions and properties of predicted enhancers have been catalogued and summarized in several enhancer-oriented databases. Because the current methods for the computational prediction of enhancers produce significantly different enhancer predictions, it will be beneficial for the research community to have an overview of the strategies and solutions developed in this field. In this review, we focus on the identification and analysis of enhancers by bioinformatics approaches. First, we describe a general framework for computational identification of enhancers, present relevant data types and discuss possible computational solutions. Next, we cover over 30 existing computational enhancer identification methods that were developed since 2000. Our review highlights advantages, limitations and potentials, while suggesting pragmatic guidelines for development of more efficient computational enhancer prediction methods. Finally, we discuss challenges and open problems of this topic, which require further consideration.

  11. Progress and challenges in bioinformatics approaches for enhancer identification

    KAUST Repository

    Kleftogiannis, Dimitrios A.; Kalnis, Panos; Bajic, Vladimir B.

    2017-01-01

    Enhancers are cis-acting DNA elements that play critical roles in distal regulation of gene expression. Identifying enhancers is an important step for understanding distinct gene expression programs that may reflect normal and pathogenic cellular conditions. Experimental identification of enhancers is constrained by the set of conditions used in the experiment. This requires multiple experiments to identify enhancers, as they can be active under specific cellular conditions but not in different cell types/tissues or cellular states. This has opened prospects for computational prediction methods that can be used for high-throughput identification of putative enhancers to complement experimental approaches. Potential functions and properties of predicted enhancers have been catalogued and summarized in several enhancer-oriented databases. Because the current methods for the computational prediction of enhancers produce significantly different enhancer predictions, it will be beneficial for the research community to have an overview of the strategies and solutions developed in this field. In this review, we focus on the identification and analysis of enhancers by bioinformatics approaches. First, we describe a general framework for computational identification of enhancers, present relevant data types and discuss possible computational solutions. Next, we cover over 30 existing computational enhancer identification methods that were developed since 2000. Our review highlights advantages, limitations and potentials, while suggesting pragmatic guidelines for development of more efficient computational enhancer prediction methods. Finally, we discuss challenges and open problems of this topic, which require further consideration.

  12. Radioimmunotherapy: Development of an effective approach. Progress report, 1987

    Energy Technology Data Exchange (ETDEWEB)

    1987-12-31

    Goals of this program are to answer the fundamental scientific questions for the development of an effective approach for delivering radiation therapy to cancer on antibody-based radiopharmaceuticals. The following list consists of highlights of developments from our program: documented therapeutic response of lymphoma in patients receiving radioimmunotherapy; development and application of quantitative radionuclide imaging techniques for therapy planning and dosimetry calculations; multicompartmental modeling and analysis of the in vivo MoAb kinetics in patients; a MoAb macrocycle chelate for Cu-67: development, production, in vitro and in vivo testing; NMR analysis of immunoradiotherapeutic effects on the metabolism of lymphoma; analysis of the variable molecular characteristics of the MoAb radiopharmaceutical, and their significance; in vivo studies in mice and patients of the metabolism of radioiodinated MoAb as well as In-111 CITC MoAb; and biodistribution of Cu-67 TETA MoAb in nude mice with human lymphoma.

  13. Progress of IFERC project in the Broader Approach Activities

    International Nuclear Information System (INIS)

    Araki, M.; Sakamoto, Y.; Hayashi, K.; Ohuchi, R.; Nishitani, T.

    2010-01-01

    For contributing to the ITER project and promoting a possible early realization of DEMO, since 2007 the International Fusion Energy Research Centre (IFERC) shall perform the activities on (1) DEMO Design and R and D Coordination, (2) Computational Simulation Centre, and (3) ITER Remote Experimentation Centre in the framework under the agreement between the Government of Japan and the European Atomic Energy Community for the joint implementation of the Broader Approach Activities in the field of fusion energy. The DEMO Design activity aims at establishing a common basis for DEMO Design, including design features of DEMO, possible common concepts of DEMO, a roadmap for DEMO, and so on. Based on the common interest of EU and Japan toward DEMO, the DEMO R and D activities have been planned and carried out for the areas which are related to DEMO blanket development: SiC/SiC composites, tritium technology, materials engineering, advanced neutron multiplier, and advanced tritium breeders for DEMO blanket. In the activity of the Computational Simulation Centre, the objective is to provide and exploit a supercomputer for large scale simulation activities to analyse experimental data on fusion plasmas, prepare scenarios for ITER operation, predict the performance of the ITER facilities and contribute to the DEMO Design.

  14. Elementary Students' Generalization and Representation of Functional Relationships: A Learning Progressions Approach

    Science.gov (United States)

    Stephens, Ana; Fonger, Nicole L.; Blanton, Maria; Knuth, Eric

    2016-01-01

    In this paper, we describe our learning progressions approach to early algebra research that involves the coordination of a curricular framework, an instructional sequence, written assessments, and levels of sophistication describing the development of students' thinking. We focus in particular on what we have learning through this approach about…

  15. Treatment of secondary burn wound progression in contact burns-a systematic review of experimental approaches.

    Science.gov (United States)

    Schmauss, Daniel; Rezaeian, Farid; Finck, Tom; Machens, Hans-Guenther; Wettstein, Reto; Harder, Yves

    2015-01-01

    After a burn injury, superficial partial-thickness burn wounds may progress to deep partial-thickness or full-thickness burn wounds, if kept untreated. This phenomenon is called secondary burn wound progression or conversion. Burn wound depth is an important determinant of patient morbidity and mortality. Therefore, reduction or even the prevention of secondary burn wound progression is one goal of the acute care of burned patients. The objective of this study was to review preclinical approaches evaluating therapies to reduce burn wound progression. A systematic review of experimental approaches in animals that aim at reducing or preventing secondary burn wound progression was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta Analysis (PRISMA) guidelines. The selected references consist of all the peer-reviewed studies performed in vivo in animals and review articles published in English, German, Italian, Spanish, or French language relevant to the topic of secondary burn wound progression. We searched MEDLINE, Cochrane Library, and Google Scholar including all the articles published from the beginning of notations to the present. The search was conducted between May 3, 2012 and December 26, 2013. We included 29 experimental studies in this review, investigating agents that maintain or increase local perfusion conditions, as well as agents that exhibit an anti-coagulatory, an anti-inflammatory, or an anti-apoptotic property. Warm water, simvastatin, EPO, or cerium nitrate may represent particularly promising approaches for the translation into clinical use in the near future. This review demonstrates promising experimental approaches that might reduce secondary burn wound progression. Nevertheless, a translation into clinical application needs to confirm the results compiled in experimental animal studies.

  16. Risk Factors for Visual Field Progression in the Groningen Longitudinal Glaucoma Study : A Comparison of Different Statistical Approaches

    NARCIS (Netherlands)

    Wesselink, Christiaan; Marcus, Michael W.; Jansonius, Nomdo M.

    2012-01-01

    Purpose: To identify risk factors for visual field progression in glaucoma and to compare different statistical approaches with this risk factor analysis. Patients and Methods: We included 221 eyes of 221 patients. Progression was analyzed using Nonparametric Progression Analysis applied to Humphrey

  17. A data fusion approach for progressive damage quantification in reinforced concrete masonry walls

    International Nuclear Information System (INIS)

    Vanniamparambil, Prashanth Abraham; Carmi, Rami; Kontsos, Antonios; Bolhassani, Mohammad; Khan, Fuad; Bartoli, Ivan; Moon, Franklin L; Hamid, Ahmad

    2014-01-01

    This paper presents a data fusion approach based on digital image correlation (DIC) and acoustic emission (AE) to detect, monitor and quantify progressive damage development in reinforced concrete masonry walls (CMW) with varying types of reinforcements. CMW were tested to evaluate their structural behavior under cyclic loading. The combination of DIC with AE provided a framework for the cross-correlation of full field strain maps on the surface of CMW with volume-inspecting acoustic activity. AE allowed in situ monitoring of damage progression which was correlated with the DIC through quantification of strain concentrations and by tracking crack evolution, visually verified. The presented results further demonstrate the relationships between the onset and development of cracking with changes in energy dissipation at each loading cycle, measured principal strains and computed AE energy, providing a promising paradigm for structural health monitoring applications on full-scale concrete masonry buildings. (paper)

  18. Total Factor Productivity Growth, Technical Progress & Efficiency Change in Vietnam Coal Industry - Nonparametric Approach

    Science.gov (United States)

    Phuong, Vu Hung

    2018-03-01

    This research applies Data Envelopment Analysis (DEA) approach to analyze Total Factor Productivity (TFP) and efficiency changes in Vietnam coal mining industry from 2007 to 2013. The TFP of Vietnam coal mining companies decreased due to slow technological progress and unimproved efficiency. The decadence of technical efficiency in many enterprises proved that the coal mining industry has a large potential to increase productivity through technical efficiency improvement. Enhancing human resource training, technology and research & development investment could help the industry to improve efficiency and productivity in Vietnam coal mining industry.

  19. Understanding the nature of science and scientific progress: A theory-building approach

    Directory of Open Access Journals (Sweden)

    Maria Chuy

    2010-11-01

    Full Text Available In 1993 Carey and Smith conjectured that the most promising way to boost students’ understanding of the nature of science is a “theory-building approach to teaching about inquiry.” The research reported here tested this conjecture by comparing results from two Grade 4 classrooms that differed in their emphasis on and technological support for creating and improving theories. One class followed a Knowledge Building approach and used Knowledge Forum®, which together emphasize theory improvement and sustained creative work with ideas. The other class followed an inquiry approach mediated through collaborative project-based activities. Apart from this, the two classes were demographically similar and both fell within the broad category of constructivist, inquiry-based approaches and employed a range of modes and media for investigative research and reports. An augmented version of Carey and Smith’s Nature of Science Interview showed that the Knowledge Building approach resulted in deeper understanding of the nature of theoretical progress, the connections between theories and facts, and the role of ideas in scientific inquiry.

  20. A generic approach does not work : Disciplinary differences as explanation for study progress in higher professional education

    NARCIS (Netherlands)

    Kamphorst, J. C.; Hofman, W. H. A.; Jansen, E. P. W. A.; Terlouw, C.

    2012-01-01

    A generic approach does not work. Disciplinary differences as explanation for study progress in higher professional education. We combine concepts of Tinto's theory on student departure and Becher's theory on disciplinary tribes for explaining study progress in universities. We collected data with

  1. Computation-aware algorithm selection approach for interlaced-to-progressive conversion

    Science.gov (United States)

    Park, Sang-Jun; Jeon, Gwanggil; Jeong, Jechang

    2010-05-01

    We discuss deinterlacing results in a computationally constrained and varied environment. The proposed computation-aware algorithm selection approach (CASA) for fast interlaced to progressive conversion algorithm consists of three methods: the line-averaging (LA) method for plain regions, the modified edge-based line-averaging (MELA) method for medium regions, and the proposed covariance-based adaptive deinterlacing (CAD) method for complex regions. The proposed CASA uses two criteria, mean-squared error (MSE) and CPU time, for assigning the method. We proposed a CAD method. The principle idea of CAD is based on the correspondence between the high and low-resolution covariances. We estimated the local covariance coefficients from an interlaced image using Wiener filtering theory and then used these optimal minimum MSE interpolation coefficients to obtain a deinterlaced image. The CAD method, though more robust than most known methods, was not found to be very fast compared to the others. To alleviate this issue, we proposed an adaptive selection approach using a fast deinterlacing algorithm rather than using only one CAD algorithm. The proposed hybrid approach of switching between the conventional schemes (LA and MELA) and our CAD was proposed to reduce the overall computational load. A reliable condition to be used for switching the schemes was presented after a wide set of initial training processes. The results of computer simulations showed that the proposed methods outperformed a number of methods presented in the literature.

  2. Comprehensive and Methodical: Diagnostic and Management Approaches to Rapidly Progressive Dementia.

    Science.gov (United States)

    Mahajan, Supriya; Appleby, Brian S

    2017-09-30

    Purpose of review The sudden emergence of a change in cognitive abilities or behavior is an important symptom that warrants medical evaluation and may represent the early stages of a rapidly progressive dementia (RPD). To correctly ascertain the cause of RPD in a given patient, the clinician must be methodical and knowledgeable about the range of potential causes and must move forward with supportive treatment, and in some cases empiric treatment, based on clinical features alone. Recent findings Significant advances in prion disease biomarkers, the molecular features of rapidly progressive Alzheimer's disease, and new detection of autoimmune limbic encephalitis disease entities have caused a shift in the diagnostic and treatment framework of RPD. Additionally, in the past decade, emerging retrospective data have led to suggested treatments in autoimmune encephalitis that, if instituted early, can protect patients against residual deficits and disease relapse. Summary Here, we provide an integrative clinical and diagnostic treatment approach that is applicable to the various forms of RPD. We have highlighted the clinical features of selected types of RPD that have experienced advances in the last 10-15 years.

  3. Approaches to LLW disposal site selection and current progress of host states

    International Nuclear Information System (INIS)

    Walsh, J.J.; Kerr, T.A.

    1990-11-01

    In accordance with the Low-Level Radioactive Waste Policy Amendments Act of 1985 and under the guidance of 10 CFR 61, States have begun entering into compacts to establish and operate regional disposal facilities for low-level radioactive waste. The progress a state makes in implementing a process to identify a specific location for a disposal site is one indication of the level of a state's commitment to meeting its responsibilities under Federal law and interstate compact agreements. During the past few years, several States have been engaged in site selection processes. The purpose of this report is to summarize the site selection approaches of some of the Host States (California, Michigan, Nebraska, New York, North Carolina, Texas, and Illinois), and their progress to date. An additional purpose of the report is to discern whether the Host States's site selection processes were heavily influenced by any common factors. One factor each state held in common was that political and public processes exerted a powerful influence on the site selection process at virtually every stage. 1 ref

  4. Structured approach to design of diagnostic test evaluation studies for chronic progressive infections in animals

    DEFF Research Database (Denmark)

    Nielsen, Søren Saxmose; Toft, Nils; Gardner, Ian Andrew

    2011-01-01

    Diagnostic test evaluations (DTEs) for chronic infections are challenging because a protracted incubation period has to be considered in the design of the DTE, and the adverse effects of infection may be widespread and progressive over an animal's entire life. Frequently, the specific purpose......) than originally intended. The objective of this paper is to outline a structured approach to the design and conduct of a DTE for diagnostic tests used for chronic infections in animals, and intended for different purposes. We describe the process from reflections about test purpose and the underlying...... of the test is not formally considered when a test is evaluated. Therefore, the result is often a DTE where test sensitivity and specificity estimates are biased, either because of problems with establishing the true infection status or because the test detects another aspect of the infection (and analyte...

  5. Drug repurposing: a systematic approach to evaluate candidate oral neuroprotective interventions for secondary progressive multiple sclerosis.

    Directory of Open Access Journals (Sweden)

    Hanna M Vesterinen

    Full Text Available To develop and implement an evidence based framework to select, from drugs already licenced, candidate oral neuroprotective drugs to be tested in secondary progressive multiple sclerosis.Systematic review of clinical studies of oral putative neuroprotective therapies in MS and four other neurodegenerative diseases with shared pathological features, followed by systematic review and meta-analyses of the in vivo experimental data for those interventions. We presented summary data to an international multi-disciplinary committee, which assessed each drug in turn using pre-specified criteria including consideration of mechanism of action.We identified a short list of fifty-two candidate interventions. After review of all clinical and pre-clinical evidence we identified ibudilast, riluzole, amiloride, pirfenidone, fluoxetine, oxcarbazepine, and the polyunsaturated fatty-acid class (Linoleic Acid, Lipoic acid; Omega-3 fatty acid, Max EPA oil as lead candidates for clinical evaluation.We demonstrate a standardised and systematic approach to candidate identification for drug rescue and repurposing trials that can be applied widely to neurodegenerative disorders.

  6. Retarding chronic kidney disease (CKD progression: a practical nutritional approach for non-dialysis CKD

    Directory of Open Access Journals (Sweden)

    Vincenzo Bellizzi

    2016-10-01

    Full Text Available This is a case report on a patient with non-dialysis chronic kidney disease (CKD in whom several nutritional issues are briefly discussed from a practical point of view. The article is accompanied by an editorial published in this Journal in relation to the 2nd International Conference of the European Renal Nutrition working group at ERA-EDTA—“Retarding CKD progression: readily available through comprehensive nutritional management?”—and focuses on several practical topics associated with the nutritional approach for the conservative treatment of non-dialysis CKD. The article is divided into 3 sections—basic nutritional assessment, nutritional targets, and nutritional follow-up in non-dialysis CKD—linked to 3 consecutive steps of the clinical follow-up of the patient and the related nutritional concerns and intervention. First visit: Baseline nutritional assessment and basic nutritional considerations in non-dialysis chronic kidney disease (CKD • What nutritional assessment/monitoring for protein-energy wasting (PEW should be employed? • Is a body mass index (BMI of 21 kg/m2 adequate? • What phosphate target should be pursued? • What are the nutritional habits in patients with incident CKD? • What protein needs and amount of dietary protein should be pursued? • Does the quality of protein matter? • What amount of dietary salt should be employed? How should this be obtained? • How should normal serum phosphate be achieved? • What diet should be recommended? Is a vegetarian diet an option? Second visit: Major nutritional targets in non-dialysis CKD • Consequences of unintentional weight loss • What is the role of the renal dietitian in helping the patient adhere to a renal diet? Intermediate visits: Nutritional follow-up in non-dialysis CKD • What treatment for calcium/parathyroid hormone (PTH will affect CKD progression? Final visits: • Would a dietary recall/intensive dietary education improve adherence with

  7. Effects of progressive fatigue and expertise on self-talk content in running: an ambulatory assessment approach

    NARCIS (Netherlands)

    Nieuwenhuys, A; Veltman, L.J.; Braakman-Jansen, Louise Marie Antoinette; Davis, P.

    2013-01-01

    Effects of Progressive Fatigue and Expertise on Self-Talk Content in Running: An Ambulatory Assessment Approach Arne Nieuwenhuys (1)*, Laurens J. Veltman (2), Louise M.A. Braakman-Jansen (2), & Paul A. Davis (3) (1) Behavioural Science Institute, Radboud University Nijmegen, The Netherlands (2)

  8. New Approaches for Early Detection of Breast Tumor Invasion or Progression

    National Research Council Canada - National Science Library

    Man, Yan-Gao

    2003-01-01

    To assess interactions between epithelial (EP) and myoepithelial (ME) cells in association with breast tumor progression and invasion, a double immunostaining technique with antibodies to smooth muscle actin (SMA...

  9. A Tissue Engineering Approach to Study the Progression of Breast Tumor Metastasis in Bone

    National Research Council Canada - National Science Library

    Che, Mingxin; Nie, Daotai

    2005-01-01

    Most patients dying of breast cancer suffer painful bone metastasis. It is our hypothesis that the invasive growth and progression of breast metastatic lesions in bone requires the participation of various constituents from "soil...

  10. A Tissue Engineering Approach to Study the Progression of Breast Tumor Metastasis in Bone

    National Research Council Canada - National Science Library

    Che, Mingxin; Nie, Daotai

    2006-01-01

    Most patients dying of breast cancer suffer painful bone metastasis. It is our hypothesis that the invasive growth and progression of breast metastatic lesions in bone requires the participation of various constituents from "soil...

  11. Technological progress and long-term energy demand - a survey of recent approaches and a Danish case

    DEFF Research Database (Denmark)

    Klinge Jacobsen, Henrik

    2001-01-01

    This paper discusses di!erent approaches to incorporating technological progress in energy-economy models and the e!ecton long-term energy demand projections. Approaches to modelling based on an exogenous annual change of energy e$ciencyto an endogenous explanation of innovation for energy...... technologies are covered. Technological progress is an important issue for modelling long-term energy demand and is often characterised as the main contributor to the di!erent energy demand forecasts from di!erent models. New economic theoretical developments in the "elds of endogenous growth and industrial...... description, two models of residential energy demand in Denmark are compared. A Danish macroeconometric model is compared to a technological vintage model that is covering electric appliances and residential heating demand. The energy demand projection of the two models diverges, and the underlying...

  12. Explicit modeling the progressive interface damage in fibrous composite: Analytical vs. numerical approach

    DEFF Research Database (Denmark)

    Kushch, V.I.; Shmegera, S.V.; Mishnaevsky, Leon

    2011-01-01

    of the multiple inclusion problem by means of complex potentials. The second, finite element model of FRC is based on the cohesive zone model of interface. Simulation of progressive debonding in FRC using the many-fiber models of composite has been performed. The advantageous features and applicability areas...... of both models are discussed. It has been shown that the developed models provide detailed analysis of the progressive debonding phenomena including the interface crack cluster formation, overall stiffness reduction and induced anisotropy of the effective elastic moduli of composite....

  13. Inference of type-specific HPV transmissibility, progression and clearance rates: a mathematical modelling approach.

    Directory of Open Access Journals (Sweden)

    Helen C Johnson

    Full Text Available Quantifying rates governing the clearance of Human Papillomavirus (HPV and its progression to clinical disease, together with viral transmissibility and the duration of naturally-acquired immunity, is essential in estimating the impact of vaccination programmes and screening or testing regimes. However, the complex natural history of HPV makes this difficult. We infer the viral transmissibility, rate of waning natural immunity and rates of progression and clearance of infection of 13 high-risk and 2 non-oncogenic HPV types, making use of a number of rich datasets from Sweden. Estimates of viral transmissibility, clearance of initial infection and waning immunity were derived in a Bayesian framework by fitting a susceptible-infectious-recovered-susceptible (SIRS transmission model to age- and type-specific HPV prevalence data from both a cross-sectional study and a randomised controlled trial (RCT of primary HPV screening. The models fitted well, but over-estimated the prevalence of four high-risk types with respect to the data. Three of these types (HPV-33, -35 and -58 are among the most closely related phylogenetically to the most prevalent HPV-16. The fourth (HPV-45 is the most closely related to HPV-18; the second most prevalent type. We suggest that this may be an indicator of cross-immunity. Rates of progression and clearance of clinical lesions were additionally estimated from longitudinal data gathered as part of the same RCT. Our estimates of progression and clearance rates are consistent with the findings of survival analysis studies and we extend the literature by estimating progression and clearance rates for non-16 and non-18 high-risk types. We anticipate that such type-specific estimates will be useful in the parameterisation of further models and in developing our understanding of HPV natural history.

  14. Pilot study of dynamic Bayesian networks approach for fault diagnostics and accident progression prediction in HTR-PM

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Yunfei; Tong, Jiejuan; Zhang, Liguo, E-mail: lgzhang@tsinghua.edu.cn; Zhang, Qin

    2015-09-15

    Highlights: • Dynamic Bayesian network is used to diagnose and predict accident progress in HTR-PM. • Dynamic Bayesian network model of HTR-PM is built based on detailed system analysis. • LOCA Simulations validate the above model even if part monitors are lost or false. - Abstract: The first high-temperature-reactor pebble-bed demonstration module (HTR-PM) is under construction currently in China. At the same time, development of a system that is used to support nuclear emergency response is in progress. The supporting system is expected to complete two tasks. The first one is diagnostics of the fault in the reactor based on abnormal sensor measurements obtained. The second one is prognostic of the accident progression based on sensor measurements obtained and operator actions. Both tasks will provide valuable guidance for emergency staff to take appropriate protective actions. Traditional method for the two tasks relies heavily on expert judgment, and has been proven to be inappropriate in some cases, such as Three Mile Island accident. To better perform the two tasks, dynamic Bayesian networks (DBN) is introduced in this paper and a pilot study based on the approach is carried out. DBN is advantageous in representing complex dynamic systems and taking full consideration of evidences obtained to perform diagnostics and prognostics. Pearl's loopy belief propagation (LBP) algorithm is recommended for diagnostics and prognostics in DBN. The DBN model of HTR-PM is created based on detailed system analysis and accident progression analysis. A small break loss of coolant accident (SBLOCA) is selected to illustrate the application of the DBN model of HTR-PM in fault diagnostics (FD) and accident progression prognostics (APP). Several advantages of DBN approach compared with other techniques are discussed. The pilot study lays the foundation for developing the nuclear emergency response supporting system (NERSS) for HTR-PM.

  15. A spray flamelet/progress variable approach combined with a transported joint PDF model for turbulent spray flames

    Science.gov (United States)

    Hu, Yong; Olguin, Hernan; Gutheil, Eva

    2017-05-01

    A spray flamelet/progress variable approach is developed for use in spray combustion with partly pre-vaporised liquid fuel, where a laminar spray flamelet library accounts for evaporation within the laminar flame structures. For this purpose, the standard spray flamelet formulation for pure evaporating liquid fuel and oxidiser is extended by a chemical reaction progress variable in both the turbulent spray flame model and the laminar spray flame structures, in order to account for the effect of pre-vaporised liquid fuel for instance through use of a pilot flame. This new approach is combined with a transported joint probability density function (PDF) method for the simulation of a turbulent piloted ethanol/air spray flame, and the extension requires the formulation of a joint three-variate PDF depending on the gas phase mixture fraction, the chemical reaction progress variable, and gas enthalpy. The molecular mixing is modelled with the extended interaction-by-exchange-with-the-mean (IEM) model, where source terms account for spray evaporation and heat exchange due to evaporation as well as the chemical reaction rate for the chemical reaction progress variable. This is the first formulation using a spray flamelet model considering both evaporation and partly pre-vaporised liquid fuel within the laminar spray flamelets. Results with this new formulation show good agreement with the experimental data provided by A.R. Masri, Sydney, Australia. The analysis of the Lagrangian statistics of the gas temperature and the OH mass fraction indicates that partially premixed combustion prevails near the nozzle exit of the spray, whereas further downstream, the non-premixed flame is promoted towards the inner rich-side of the spray jet since the pilot flame heats up the premixed inner spray zone. In summary, the simulation with the new formulation considering the reaction progress variable shows good performance, greatly improving the standard formulation, and it provides new

  16. Inhibitors of SOD1 Interaction as an Approach to Slow the Progressive Spread of ALS Symptoms

    Science.gov (United States)

    2016-07-01

    the progression of ALS caused by mutations in this protein . To accomplish this goal, we developed an assay that is based on the observation that the...force. In our assay , this force is the normal interaction that occurs when 2 individual SOD1 proteins come together to form a normal active enzyme...Using recombinant DNA, we create fusion proteins of SOD1 and each half of the luciferase enzyme. In the past year, we have characterized and optimized

  17. Perspective Insights into Disease Progression, Diagnostics, and Therapeutic Approaches in Alzheimer's Disease: A Judicious Update

    Directory of Open Access Journals (Sweden)

    Arif Tasleem Jan

    2017-11-01

    Full Text Available Alzheimer's disease (AD is a neurodegenerative disorder characterized by the progressive accumulation of β-amyloid fibrils and abnormal tau proteins in and outside of neurons. Representing a common form of dementia, aggravation of AD with age increases the morbidity rate among the elderly. Although, mutations in the ApoE4 act as potent risk factors for sporadic AD, familial AD arises through malfunctioning of APP, PSEN-1, and−2 genes. AD progresses through accumulation of amyloid plaques (Aβ and neurofibrillary tangles (NFTs in brain, which interfere with neuronal communication. Cellular stress that arises through mitochondrial dysfunction, endoplasmic reticulum malfunction, and autophagy contributes significantly to the pathogenesis of AD. With high accuracy in disease diagnostics, Aβ deposition and phosphorylated tau (p-tau are useful core biomarkers in the cerebrospinal fluid (CSF of AD patients. Although five drugs are approved for treatment in AD, their failures in achieving complete disease cure has shifted studies toward a series of molecules capable of acting against Aβ and p-tau. Failure of biologics or compounds to cross the blood-brain barrier (BBB in most cases advocates development of an efficient drug delivery system. Though liposomes and polymeric nanoparticles are widely adopted for drug delivery modules, their use in delivering drugs across the BBB has been overtaken by exosomes, owing to their promising results in reducing disease progression.

  18. Combined macroscopic and microscopic approach to the fracture of metals. Technical progress report

    International Nuclear Information System (INIS)

    Asaro, R.J.; Gurland, J.; Needleman, A.; Rice, R.J.

    1979-06-01

    Progress is reported on microscopic fracture mechanisms, including studies of void and crack initiation in steels in the absence and presence of hydrogen, the effects of hydrogen on ductile fracture in medium and high carbon steels; elastic--plastic crack growth including the quasi-stable growth of cracks in ductile solids under increasing load and conditions of instability; and elevated temperature rupture including analysis of the stress field near a crack tip in an elastic-nonlinear viscous material under tensile load as well as the processes of diffusion, and cavitation of grain boundaries in plastically creeping materials

  19. Quality assurance in proton therapy: a systematic approach in progress at Orsay

    International Nuclear Information System (INIS)

    Mazal, A.; Habrand, J.L.; Laforture, F.; Breteau, N.; Mazal, A.; Habrand, J.L.; Breteau, N.

    1996-01-01

    The degree of accuracy and reliability required in proton therapy can only be guaranteed of a comprehensive quality assurance (QA) programme is established. Such a programme obviously has common features with general QA in radiotherapy, but some aspects are specific to the use of protons and particularly to the characteristics of each facility. A study is in progress at Orsay to convert a series of quality controls into a systematic quality assurance programme. It includes some basic steps on organisation, setting up a QA committee and QA task groups, organizing meetings, policies, procedures, records qualifications, and determining some examples of tolerance in controls. Among some critical and specific points identified in this process are the combined treatment with photons at different institutions, the specificity of a non-hospital and complex facility, the high degree of precision required for the patient setup, and the need to develop in-house basic tools such as the treatment planning system. The inclusion of all the patients in prospective well-defined clinical trials, the comparison with alternative techniques and the radiobiological studies are considered as fundamentals for the QA programme. Present dosimetric and radiobiological intercomparisons between proton-therapy centres are considered as partial audits. A study is in progress to establish common dosimetric and clinical protocols, radiological models and dose and volume specifications. In spite of the differences between the existing facilities, it should be possible to obtain international consensus on general guidelines for a QA programme in proton therapy. (author)

  20. Cohesive Laws and Progressive Damage Analysis of Composite Bonded Joints, a Combined Numerical/Experimental Approach

    Science.gov (United States)

    Girolamo, Donato; Davila, Carlos G.; Leone, Frank A.; Lin, Shih-Yung

    2015-01-01

    The results of an experimental/numerical campaign aimed to develop progressive damage analysis (PDA) tools for predicting the strength of a composite bonded joint under tensile loads are presented. The PDA is based on continuum damage mechanics (CDM) to account for intralaminar damage, and cohesive laws to account for interlaminar and adhesive damage. The adhesive response is characterized using standard fracture specimens and digital image correlation (DIC). The displacement fields measured by DIC are used to calculate the J-integrals, from which the associated cohesive laws of the structural adhesive can be derived. A finite element model of a sandwich conventional splice joint (CSJ) under tensile loads was developed. The simulations, in agreement with experimental tests, indicate that the model is capable of predicting the interactions of damage modes that lead to the failure of the joint.

  1. Practical Approaches to Evaluating Progress and Outcomes in Community-Wide Teen Pregnancy Prevention Initiatives.

    Science.gov (United States)

    Tevendale, Heather D; Condron, D Susanne; Garraza, Lucas Godoy; House, L Duane; Romero, Lisa M; Brooks, Megan A M; Walrath, Christine

    2017-03-01

    This paper presents an overview of the key evaluation components for a set of community-wide teen pregnancy prevention initiatives. We first describe the performance measures selected to assess progress toward meeting short-term objectives on the reach and quality of implementation of evidence-based teen pregnancy prevention interventions and adolescent reproductive health services. Next, we describe an evaluation that will compare teen birth rates in intervention communities relative to synthetic control communities. Synthetic controls are developed via a data-driven technique that constructs control communities by combining information from a pool of communities that are similar to the intervention community. Finally, we share lessons learned thus far in the evaluation of the project, with a focus on those lessons that may be valuable for local communities evaluating efforts to reduce teen pregnancy. Copyright © 2016 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  2. EPODE approach for childhood obesity prevention : methods, progress and international development

    NARCIS (Netherlands)

    Borys, J.M.; Le Bodo, Y.; Jebb, S.A.; Seidell, J C; Summerbell, C.; Richard, D.; De Henauw, S.; Moreno, L.A.; Romon, M.; Visscher, T L S; Raffin, S.; Swinburn, B.

    Childhood obesity is a complex issue and needs multi-stakeholder involvement at all levels to foster healthier lifestyles in a sustainable way. 'Ensemble Prévenons l'Obésité Des Enfants' (EPODE, Together Let's Prevent Childhood Obesity) is a large-scale, coordinated, capacity-building approach for

  3. Understanding the Nature of Science and Scientific Progress: A Theory-Building Approach

    Science.gov (United States)

    Chuy, Maria; Scardamalia, Marlene; Bereiter, Carl; Prinsen, Fleur; Resendes, Monica; Messina, Richard; Hunsburger, Winifred; Teplovs, Chris; Chow, Angela

    2010-01-01

    In 1993 Carey and Smith conjectured that the most promising way to boost students' understanding of the nature of science is a "theory-building approach to teaching about inquiry." The research reported here tested this conjecture by comparing results from two Grade 4 classrooms that differed in their emphasis on and technological…

  4. Predicting progression of mild cognitive impairment to dementia using neuropsychological data: a supervised learning approach using time windows.

    Science.gov (United States)

    Pereira, Telma; Lemos, Luís; Cardoso, Sandra; Silva, Dina; Rodrigues, Ana; Santana, Isabel; de Mendonça, Alexandre; Guerreiro, Manuela; Madeira, Sara C

    2017-07-19

    Predicting progression from a stage of Mild Cognitive Impairment to dementia is a major pursuit in current research. It is broadly accepted that cognition declines with a continuum between MCI and dementia. As such, cohorts of MCI patients are usually heterogeneous, containing patients at different stages of the neurodegenerative process. This hampers the prognostic task. Nevertheless, when learning prognostic models, most studies use the entire cohort of MCI patients regardless of their disease stages. In this paper, we propose a Time Windows approach to predict conversion to dementia, learning with patients stratified using time windows, thus fine-tuning the prognosis regarding the time to conversion. In the proposed Time Windows approach, we grouped patients based on the clinical information of whether they converted (converter MCI) or remained MCI (stable MCI) within a specific time window. We tested time windows of 2, 3, 4 and 5 years. We developed a prognostic model for each time window using clinical and neuropsychological data and compared this approach with the commonly used in the literature, where all patients are used to learn the models, named as First Last approach. This enables to move from the traditional question "Will a MCI patient convert to dementia somewhere in the future" to the question "Will a MCI patient convert to dementia in a specific time window". The proposed Time Windows approach outperformed the First Last approach. The results showed that we can predict conversion to dementia as early as 5 years before the event with an AUC of 0.88 in the cross-validation set and 0.76 in an independent validation set. Prognostic models using time windows have higher performance when predicting progression from MCI to dementia, when compared to the prognostic approach commonly used in the literature. Furthermore, the proposed Time Windows approach is more relevant from a clinical point of view, predicting conversion within a temporal interval

  5. Computational enzyme design approaches with significant biological outcomes: progress and challenges

    OpenAIRE

    Li, Xiaoman; Zhang, Ziding; Song, Jiangning

    2012-01-01

    Enzymes are powerful biocatalysts, however, so far there is still a large gap between the number of enzyme-based practical applications and that of naturally occurring enzymes. Multiple experimental approaches have been applied to generate nearly all possible mutations of target enzymes, allowing the identification of desirable variants with improved properties to meet the practical needs. Meanwhile, an increasing number of computational methods have been developed to assist in the modificati...

  6. Combined macroscopic and microscopic approach to the fracture of metals. Annual progress report, 1980-1981

    International Nuclear Information System (INIS)

    Asaro, R.J.; Gurland, J.; Needleman, A.; Rice, J.R.

    1981-06-01

    Recent progress was achieved in refining and generalizing the methods previously developed for treating the stable crack growth problem, with particular attention to the approximate asymptotic solution of Rice, Drugan and Sham for stress and deformation fields near the tip of a growing crack. The microstructural aspects of ductile fracture were studied in dual-phase steels and high-strength 4340 steels. Very interesting results were obtained in the work on hydrogen effects in steels. In medium strength steels, the ductility-reducing effect of hydrogen is tentatively attributed to the accumulation of hydrogen at internal interfaces with a resulting loss in the resistance to interfacial separation. Extension of Needleman and Rice's work on the growth of cavities at elevated temperatures to the investigation of the effects of triaxial stressing relates the rate of void growth by grain boundary diffusion and dislocation creep to the triaxiality. It provides a good model to analyze the growth of macro-cracks in polycrystals by the mechanisms of growth and coalescence of micro-voids

  7. An observation-based progression modeling approach to spring and autumn deciduous tree phenology

    Science.gov (United States)

    Yu, Rong; Schwartz, Mark D.; Donnelly, Alison; Liang, Liang

    2016-03-01

    It is important to accurately determine the response of spring and autumn phenology to climate change in forest ecosystems, as phenological variations affect carbon balance, forest productivity, and biodiversity. We observed phenology intensively throughout spring and autumn in a temperate deciduous woodlot at Milwaukee, WI, USA, during 2007-2012. Twenty-four phenophase levels in spring and eight in autumn were recorded for 106 trees, including white ash, basswood, white oak, boxelder, red oak, and hophornbeam. Our phenological progression models revealed that accumulated degree-days and day length explained 87.9-93.4 % of the variation in spring canopy development and 75.8-89.1 % of the variation in autumn senescence. In addition, the timing of community-level spring and autumn phenophases and the length of the growing season from 1871 to 2012 were reconstructed with the models developed. All simulated spring phenophases significantly advanced at a rate from 0.24 to 0.48 days/decade ( p ≤ 0.001) during the 1871-2012 period and from 1.58 to 2.00 days/decade ( p coloration) and 0.50 (full-leaf coloration) days/decade ( p coloration and leaf fall, and suggested accelerating simulated ecosystem responses to climate warming over the last four decades in comparison to the past 142 years.

  8. Current National Approach to Healthcare ICT Standardization: Focus on Progress in New Zealand.

    Science.gov (United States)

    Park, Young-Taek; Atalag, Koray

    2015-07-01

    Many countries try to efficiently deliver high quality healthcare services at lower and manageable costs where healthcare information and communication technologies (ICT) standardisation may play an important role. New Zealand provides a good model of healthcare ICT standardisation. The purpose of this study was to review the current healthcare ICT standardisation and progress in New Zealand. This study reviewed the reports regarding the healthcare ICT standardisation in New Zealand. We also investigated relevant websites related with the healthcare ICT standards, most of which were run by the government. Then, we summarised the governance structure, standardisation processes, and their output regarding the current healthcare ICT standards status of New Zealand. New Zealand government bodies have established a set of healthcare ICT standards and clear guidelines and procedures for healthcare ICT standardisation. Government has actively participated in various enactments of healthcare ICT standards from the inception of ideas to their eventual retirement. Great achievements in eHealth have already been realized, and various standards are currently utilised at all levels of healthcare regionally and nationally. Standard clinical terminologies, such as International Classification of Diseases (ICD) and Systematized Nomenclature of Medicine - Clinical Terms (SNOMED-CT) have been adopted and Health Level Seven (HL7) standards are actively used in health information exchanges. The government to New Zealand has well organised ICT institutions, guidelines, and regulations, as well as various programs, such as e-Medications and integrated care services. Local district health boards directly running hospitals have effectively adopted various new ICT standards. They might already be benefiting from improved efficiency resulting from healthcare ICT standardisation.

  9. A Year of Progress: NASA's Space Launch System Approaches Critical Design Review

    Science.gov (United States)

    Askins, Bruce; Robinson, Kimberly

    2015-01-01

    NASA's Space Launch System (SLS) made significant progress on the manufacturing floor and on the test stand in 2014 and positioned itself for a successful Critical Design Review in mid-2015. SLS, the world's only exploration-class heavy lift rocket, has the capability to dramatically increase the mass and volume of human and robotic exploration. Additionally, it will decrease overall mission risk, increase safety, and simplify ground and mission operations - all significant considerations for crewed missions and unique high-value national payloads. Development now is focused on configuration with 70 metric tons (t) of payload to low Earth orbit (LEO), more than double the payload of the retired Space Shuttle program or current operational vehicles. This "Block 1" design will launch NASA's Orion Multi-Purpose Crew Vehicle (MPCV) on an uncrewed flight beyond the Moon and back and the first crewed flight around the Moon. The current design has a direct evolutionary path to a vehicle with a 130t lift capability that offers even more flexibility to reduce planetary trip times, simplify payload design cycles, and provide new capabilities such as planetary sample returns. Every major element of SLS has successfully completed its Critical Design Review and now has hardware in production or testing. In fact, the SLS MPCV-to-Stage-Adapter (MSA) flew successfully on the Exploration Flight Test (EFT) 1 launch of a Delta IV and Orion spacecraft in December 2014. The SLS Program is currently working toward vehicle Critical Design Review in mid-2015. This paper will discuss these and other technical and programmatic successes and challenges over the past year and provide a preview of work ahead before the first flight of this new capability.

  10. The HAAPI (Home Arm Assistance Progression Initiative) Trial: A Novel Robotics Delivery Approach in Stroke Rehabilitation.

    Science.gov (United States)

    Wolf, Steven L; Sahu, Komal; Bay, R Curtis; Buchanan, Sharon; Reiss, Aimee; Linder, Susan; Rosenfeldt, Anson; Alberts, Jay

    2015-01-01

    Geographical location, socioeconomic status, and logistics surrounding transportation impede access of poststroke individuals to comprehensive rehabilitative services. Robotic therapy may enhance telerehabilitation by delivering consistent and state-of-the art therapy while allowing remote monitoring and adjusting therapy for underserved populations. The Hand Mentor Pro (HMP) was incorporated within a home exercise program (HEP) to improve upper-extremity (UE) functional capabilities poststroke. To determine the efficacy of a home-based telemonitored robotic-assisted therapy as part of a HEP compared with a dose-matched HEP-only intervention among individuals less than 6 months poststroke and characterized as underserved. In this prospective, single-blinded, multisite, randomized controlled trial, 99 hemiparetic participants with limited access to UE rehabilitation were randomized to either (1) the experimental group, which received combined HEP and HMP for 3 h/d ×5 days ×8 weeks, or (2) the control group, which received HEP only at an identical dosage. Weekly communication between the supervising therapist and participant promoted compliance and progression of the HEP and HMP prescription. The Action Research Arm Test and Wolf Motor Function Test along with the Fugl-Meyer Assessment (UE) were primary and secondary outcome measures, respectively, undertaken before and after the interventions. Both groups demonstrated improvement across all UE outcomes. Robotic + HEP and HEP only were both effectively delivered remotely. There was no difference between groups in change in motor function over time. Additional research is necessary to determine the appropriate dosage of HMP and HEP. © The Author(s) 2015.

  11. Creating a test blueprint for a progress testing program: A paired-comparisons approach.

    Science.gov (United States)

    von Bergmann, HsingChi; Childs, Ruth A

    2018-03-01

    Creating a new testing program requires the development of a test blueprint that will determine how the items on each test form are distributed across possible content areas and practice domains. To achieve validity, categories of a blueprint are typically based on the judgments of content experts. How experts judgments are elicited and combined is important to the quality of resulting test blueprints. Content experts in dentistry participated in a day-long faculty-wide workshop to discuss, refine, and confirm the categories and their relative weights. After reaching agreement on categories and their definitions, experts judged the relative importance between category pairs, registering their judgments anonymously using iClicker, an audience response system. Judgments were combined in two ways: a simple calculation that could be performed during the workshop and a multidimensional scaling of the judgments performed later. Content experts were able to produce a set of relative weights using this approach. The multidimensional scaling yielded a three-dimensional model with the potential to provide deeper insights into the basis of the experts' judgments. The approach developed and demonstrated in this study can be applied across academic disciplines to elicit and combine content experts judgments for the development of test blueprints.

  12. Progressing toward a more culturally competent approach to dental care for African American elders.

    Science.gov (United States)

    Slaughter, Ann; Smith, Virginia J; Taylor, Lynne

    2004-01-01

    This study was conducted to understand perceptions that may influence oral self-care behaviors among elderly African American adults living in an urban community. Four focus groups at two senior centers were recruited, involving a total of 25 participants. Content analysis and ethnographic summaries were used to identify themes, common concepts and language. The results indicated that although the participants recognized the advantages of routine brushing, the importance of keeping teeth clean to prevent gum disease was not widely acknowledged. On the basis of these focus groups, the authors suggest that health promotion approaches for adults who are elderly should be linked to the audience's cultural norms and perceptions regarding the benefits of oral hygiene practices.

  13. Conservation of coral reefs through active restoration measures: recent approaches and last decade progress.

    Science.gov (United States)

    Rinkevich, Baruch

    2005-06-15

    The scientific discipline of active restoration of denuded coral reef areas has drawn much attention in the past decade as it became evident that this ecosystem does not often recover naturally from anthropogenic stress without manipulation. Essentially, the choices are eitherthe continuous degradation of the reefs or active restoration to encourage reef development. As a result, worldwide restoration operations during the past decade have been recognized as being a major tool for reef rehabilitation. This situation has also stirred discussions and debates on the various restoration measures suggested as management options, supplementary to the traditional conservation acts. The present essay reviews past decade's (1994-2004) approaches and advances in coral reef restoration. While direct coral transplantation is still the primer vehicle of operations used, the concept of in situ and ex situ coral nurseries (the gardening concept), where coral materials (nubbins, branches, spats) are maricultured to a size suitable for transplantation, has been gaining recognition. The use of nubbins (down to the size of a single or few polyps) has been suggested and employed as a unique technique for mass production of coral colonies. Restoration of ship grounding sites and the use of artificial reefs have become common tools for specific restoration needs. Substrate stabilization, 3-D structural consideration of developing colonies, and the use of molecular/biochemical tools are part of novel technology approaches developed in the past decade. Economic considerations for reef restoration have become an important avenue for evaluating success of restoration activities. It has been suggested that landscape restoration and restoration genetics are important issues to be studied. In the future, as coral reef restoration may become the dominant conservation act, there would be the need not only to develop improved protocols but also to define the conceptual bases.

  14. Progress in evaluation of human observer visual detection performance using the ROC curve approach

    International Nuclear Information System (INIS)

    Metz, C.E.; Starr, S.J.; Lusted, L.B.; Rossmann, K.

    1976-01-01

    The ROC approach to analysis of human observer detection performance as playing a key role in elucidation the relationships among the physical parameters of an imaging operation, the ability of a human observer to use the image to make decisions regarding the state of health or disease in a medical diagnostic situation, and the medical and social utility of those decisions, was studied. The conventional ROC curve describing observer performance in simple detection tasks can be used to predict observer performance in complex detection tasks. The conventional ROC curve thus provides a description of observer detection performance which is useful in situations more relevant clinically than those for which it is measured. Similar predictions regarding observer performance in identification and recognition tasks are currently being sought. The ROC curve can be used to relate signal detectability to various measures of the diagnostic and social benefit derived from a medical imaging procedure. These relationships provide a means for assessing the relative desirability of alternative diagnostic techniques and can be used to evaluate combinations of diagnostic studies

  15. EPODE approach for childhood obesity prevention: methods, progress and international development.

    Science.gov (United States)

    Borys, J-M; Le Bodo, Y; Jebb, S A; Seidell, J C; Summerbell, C; Richard, D; De Henauw, S; Moreno, L A; Romon, M; Visscher, T L S; Raffin, S; Swinburn, B

    2012-04-01

    Childhood obesity is a complex issue and needs multi-stakeholder involvement at all levels to foster healthier lifestyles in a sustainable way. 'Ensemble Prévenons l'Obésité Des Enfants' (EPODE, Together Let's Prevent Childhood Obesity) is a large-scale, coordinated, capacity-building approach for communities to implement effective and sustainable strategies to prevent childhood obesity. This paper describes EPODE methodology and its objective of preventing childhood obesity. At a central level, a coordination team, using social marketing and organizational techniques, trains and coaches a local project manager nominated in each EPODE community by the local authorities. The local project manager is also provided with tools to mobilize local stakeholders through a local steering committee and local networks. The added value of the methodology is to mobilize stakeholders at all levels across the public and the private sectors. Its critical components include political commitment, sustainable resources, support services and a strong scientific input--drawing on the evidence-base--together with evaluation of the programme. Since 2004, EPODE methodology has been implemented in more than 500 communities in six countries. Community-based interventions are integral to childhood obesity prevention. EPODE provides a valuable model to address this challenge. © 2011 The Authors. obesity reviews © 2011 International Association for the Study of Obesity.

  16. The Impacts of Technical Progress on Sulfur Dioxide Kuznets Curve in China: A Spatial Panel Data Approach

    Directory of Open Access Journals (Sweden)

    Zhimin Zhou

    2017-04-01

    Full Text Available This paper aims to reveal the nexus for sulfur dioxide (SO2 emission and income, as well as the effects of technical progress on SO2 emission in China based on environment Kuznets curve (EKC hypothesis. The spatial panel technique is used in case the coefficient estimates are biased due to the negligence of spatial dependence. With the provincial panel data of China from 2004 to 2014, this is the first research that finds an inverse N-trajectory of the relationship between SO2 emission and economic growth and confirms the beneficial impacts of technical advancement on SO2 emission abatement. The empirical results also suggest that the industrial structure change is an important driving force of the SO2 EKC. In addition, the direct and spillover effects of determinants on sulfur emission are clarified and estimated by a correct approach. Finally, we check the stability of our conclusions on the EKC shape for SO2 and technical progress effects when controlling for different variables and specifications, through which we find the turning points are sensitive to variables selections.

  17. International vision requirements for driver licensing and disability pensions: using a milestone approach in characterization of progressive eye disease

    Directory of Open Access Journals (Sweden)

    Alain M Bron

    2010-11-01

    Full Text Available Alain M Bron1, Ananth C Viswanathan2, Ulrich Thelen3, Renato de Natale4, Antonio Ferreras5, Jens Gundgaard6, Gail Schwartz7, Patricia Buchholz81Department of Ophthalmology, University Hospital, Dijon, France; 2Glaucoma Research Unit, Moorfields Eye Hospital NHS Foundation Trust and Department of Genetics, University College of London Institute of Ophthalmology, London, UK; 3Private Practice, Munster, Germany; 4Ospedale Civile di Monselice, Monselice, Italy; 5Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain; 6COWI, Kolding, Denmark; 7Wilmer Eye Institute, Johns Hopkins University, Glaucoma Consultants, Baltimore, MD, USA; 8Patricia Buchholz Consulting, Karlsruhe, GermanyObjective: Low vision that causes forfeiture of driver’s licenses and collection of disability pension benefits can lead to negative psychosocial and economic consequences. The purpose of this study was to review the requirements for holding a driver’s license and rules for obtaining a disability pension due to low vision. Results highlight the possibility of using a milestone approach to describe progressive eye disease.Methods: Government and research reports, websites, and journal articles were evaluated to review rules and requirements in Germany, Spain, Italy, France, the UK, and the US.Results: Visual acuity limits are present in all driver’s license regulations. In most countries, the visual acuity limit is 0.5. Visual field limits are included in some driver’s license regulations. In Europe, binocular visual field requirements typically follow the European Union standard of ≥120°. In the US, the visual field requirements are typically between 110° and 140°. Some countries distinguish between being partially sighted and blind in the definition of legal blindness, and in others there is only one limit.Conclusions: Loss of driving privileges could be used as a milestone to monitor progressive eye disease. Forfeiture could be standardized as a

  18. Multiple player tracking in sports video: a dual-mode two-way bayesian inference approach with progressive observation modeling.

    Science.gov (United States)

    Xing, Junliang; Ai, Haizhou; Liu, Liwei; Lao, Shihong

    2011-06-01

    Multiple object tracking (MOT) is a very challenging task yet of fundamental importance for many practical applications. In this paper, we focus on the problem of tracking multiple players in sports video which is even more difficult due to the abrupt movements of players and their complex interactions. To handle the difficulties in this problem, we present a new MOT algorithm which contributes both in the observation modeling level and in the tracking strategy level. For the observation modeling, we develop a progressive observation modeling process that is able to provide strong tracking observations and greatly facilitate the tracking task. For the tracking strategy, we propose a dual-mode two-way Bayesian inference approach which dynamically switches between an offline general model and an online dedicated model to deal with single isolated object tracking and multiple occluded object tracking integrally by forward filtering and backward smoothing. Extensive experiments on different kinds of sports videos, including football, basketball, as well as hockey, demonstrate the effectiveness and efficiency of the proposed method.

  19. The Progressive Approach to EMDR Group Therapy for Complex Trauma and Dissociation: A Case-Control Study

    Directory of Open Access Journals (Sweden)

    Ana I. Gonzalez-Vazquez

    2018-02-01

    Full Text Available Eye Movement Desensitization and Reprocessing is a psychotherapeutic approach with recognized efficiency in treating post-traumatic stress disorder (PTSD, which is being used and studied in other psychiatric diagnoses partially based on adverse and traumatic life experiences. Nevertheless, there is not enough empirical evidence at the moment to support its usefulness in a diagnosis other than PTSD. It is commonly accepted that the use of EMDR in severely traumatized patients requires an extended stabilization phase. Some authors have proposed integrating both the theory of structural dissociation of the personality and the adaptive information processing model guiding EMDR therapy. One of these proposals is the Progressive Approach. Some of these EMDR procedures will be evaluated in a group therapy format, integrating them along with emotional regulation, dissociation, and trauma-oriented psychoeducational interventions. Patients presenting a history of severe traumatization, mostly early severe and interpersonal trauma, combined with additional significant traumatizing events in adulthood were included. In order to discriminate the specific effect of EMDR procedures, two types of groups were compared: TAU (treatment as usual: psychoeducational intervention only vs. TAU+EMDR (the same psychoeducational intervention plus EMDR specific procedures. In pre-post comparison, more variables presented positive changes in the group including EMDR procedures. In the TAU+EMDR group, 4 of the 5 measured variables presented significant and positive changes: general health (GHQ, general satisfaction (Schwartz, subjective well-being, and therapy session usefulness assessment. On the contrary, only 2 of the 5 variables in the TAU group showed statistically significant changes: general health (GHQ, and general satisfaction (Schwartz. Regarding post-test inter-group comparison, improvement in subjective well-being was related to belonging to the group that

  20. Teacher Progress Monitoring of Instructional and Behavioral Management Practices: An Evidence-Based Approach to Improving Classroom Practices

    Science.gov (United States)

    Reddy, Linda A.; Dudek, Christopher M.

    2014-01-01

    In the era of teacher evaluation and effectiveness, assessment tools that identify and monitor educators' instruction and behavioral management practices are in high demand. The Classroom Strategies Scale (CSS) Observer Form is a multidimensional teacher progress monitoring tool designed to assess teachers' usage of instructional and behavioral…

  1. [Signal transduction in plant development: Chemical and biochemical approaches to receptor identification]. Progress report, [May 15, 1993--May 14, 1994

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    Progress is reported on studies concerning NAD(P)H-2,6-DMBQ oxidoreductase of Striga asiatica aimed at elucidating basic biochemical parameters of Striga. Reported studies include characterization of the enzyme, development of Striga molecular genetics, and development of a redox model for germination control.

  2. Impact of Environmental Regulation and Technical Progress on Industrial Carbon Productivity: An Approach Based on Proxy Measure

    Directory of Open Access Journals (Sweden)

    Huan Zhang

    2016-08-01

    Full Text Available This research aims to study the main influencing factors of China’s industrial carbon productivity by incorporating environmental regulation and technical progress into an econometric model. The paper focuses on data from 35 of China’s industrial sectors and covers the period from 2006 to 2014, in order to examine the impact of environmental regulation and technical progress on carbon productivity. Methods applied include panel fixed effect model, panel random effect model and two stage least squares with instrumental variables (IV-2SLS. The effect of environmental regulation and technical progress has industrial heterogeneity. The paper subdivides industrial sectors into capital and technology intensive, resource intensive and labor intensive sectors according to factor intensiveness. The estimation results of the subgroups have uncovered that for capital and technology intensive and resource intensive sectors, environmental regulation has a more significant impact than technical progress; while for labor intensive sectors, innovation more significantly influences carbon productivity. In addition, foreign direct investment (FDI and industrialization level facilitate improving carbon productivity for the full sample. By contrast, industrial structure inhibits the overall industrial carbon productivity. The industry-specific results indicate that for capital and technology intensive sectors, optimizing of the industrial structure can improve carbon productivity; for resource intensive sectors, FDI and energy consumption structure should be emphasized more; for labor intensive sectors, industrialization levels help enhance carbon productivity. Finally the industrial sector-specific policy suggestions are proposed.

  3. A Systematic Approach to Analyse Critical Tribological Parameters in an Industrial Case Study of Progressive Die Sequence Production

    DEFF Research Database (Denmark)

    Üstünyagiz, Esmeray; Nielsen, Chris V.; Bay, Niels

    the tribologically critical parameters in an industrial production line in which a progressive tool sequence is used. The current industrial case is based on multistage deep drawing followed by an ironing operation. Severe reduction in the ironing stage leads to high interface temperature and pressure. As a result......, subsequent lubricant film breakdown in the production line occurs. The methodology combines finite element simulations and experimental measurements to determine tribological parameters which will later be used in laboratory testing of possible tribology systems....

  4. Evaluating Structural Change Approaches to Health Promotion: An Exploratory Scoping Review of a Decade of U.S. Progress

    Science.gov (United States)

    Asada, Yuka; Lieberman, Lisa D.; Neubauer, Leah C.; Hanneke, Rosie; Fagen, Michael C.

    2018-01-01

    Structural change approaches--also known as policy and environmental changes--are becoming increasingly common in health promotion, yet our understanding of how to evaluate them is still limited. An exploratory scoping review of the literature was conducted to understand approaches and methods used to evaluate structural change interventions in…

  5. Modeling the impacts of climate change and technical progress on the wheat yield in inland China: An autoregressive distributed lag approach.

    Science.gov (United States)

    Zhai, Shiyan; Song, Genxin; Qin, Yaochen; Ye, Xinyue; Lee, Jay

    2017-01-01

    This study aims to evaluate the impacts of climate change and technical progress on the wheat yield per unit area from 1970 to 2014 in Henan, the largest agricultural province in China, using an autoregressive distributed lag approach. The bounded F-test for cointegration among the model variables yielded evidence of a long-run relationship among climate change, technical progress, and the wheat yield per unit area. In the long run, agricultural machinery and fertilizer use both had significantly positive impacts on the per unit area wheat yield. A 1% increase in the aggregate quantity of fertilizer use increased the wheat yield by 0.19%. Additionally, a 1% increase in machine use increased the wheat yield by 0.21%. In contrast, precipitation during the wheat growth period (from emergence to maturity, consisting of the period from last October to June) led to a decrease in the wheat yield per unit area. In the short run, the coefficient of the aggregate quantity of fertilizer used was negative. Land size had a significantly positive impact on the per unit area wheat yield in the short run. There was no significant short-run or long-run impact of temperature on the wheat yield per unit area in Henan Province. The results of our analysis suggest that climate change had a weak impact on the wheat yield, while technical progress played an important role in increasing the wheat yield per unit area. The results of this study have implications for national and local agriculture policies under climate change. To design well-targeted agriculture adaptation policies for the future and to reduce the adverse effects of climate change on the wheat yield, climate change and technical progress factors should be considered simultaneously. In addition, adaptive measures associated with technical progress should be given more attention.

  6. Modeling the impacts of climate change and technical progress on the wheat yield in inland China: An autoregressive distributed lag approach.

    Directory of Open Access Journals (Sweden)

    Shiyan Zhai

    Full Text Available This study aims to evaluate the impacts of climate change and technical progress on the wheat yield per unit area from 1970 to 2014 in Henan, the largest agricultural province in China, using an autoregressive distributed lag approach. The bounded F-test for cointegration among the model variables yielded evidence of a long-run relationship among climate change, technical progress, and the wheat yield per unit area. In the long run, agricultural machinery and fertilizer use both had significantly positive impacts on the per unit area wheat yield. A 1% increase in the aggregate quantity of fertilizer use increased the wheat yield by 0.19%. Additionally, a 1% increase in machine use increased the wheat yield by 0.21%. In contrast, precipitation during the wheat growth period (from emergence to maturity, consisting of the period from last October to June led to a decrease in the wheat yield per unit area. In the short run, the coefficient of the aggregate quantity of fertilizer used was negative. Land size had a significantly positive impact on the per unit area wheat yield in the short run. There was no significant short-run or long-run impact of temperature on the wheat yield per unit area in Henan Province. The results of our analysis suggest that climate change had a weak impact on the wheat yield, while technical progress played an important role in increasing the wheat yield per unit area. The results of this study have implications for national and local agriculture policies under climate change. To design well-targeted agriculture adaptation policies for the future and to reduce the adverse effects of climate change on the wheat yield, climate change and technical progress factors should be considered simultaneously. In addition, adaptive measures associated with technical progress should be given more attention.

  7. Promising approaches to circumvent the blood-brain barrier: progress, pitfalls and clinical prospects in brain cancer

    OpenAIRE

    Papademetriou, Iason T; Porter, Tyrone

    2015-01-01

    Brain drug delivery is a major challenge for therapy of central nervous system (CNS) diseases. Biochemical modifications of drugs or drug nanocarriers, methods of local delivery, and blood–brain barrier (BBB) disruption with focused ultrasound and microbubbles are promising approaches which enhance transport or bypass the BBB. These approaches are discussed in the context of brain cancer as an example in CNS drug development. Targeting to receptors enabling transport across the BBB offers non...

  8. Progression following neoadjuvant systemic chemotherapy may not be a contraindication to a curative approach for colorectal carcinomatosis.

    Science.gov (United States)

    Passot, Guillaume; Vaudoyer, Delphine; Cotte, Eddy; You, Benoit; Isaac, Sylvie; Noël Gilly, François; Mohamed, Faheez; Glehen, Olivier

    2012-07-01

    The objective of this retrospective study was to evaluate the influence of neoadjuvant systemic chemotherapy on patients with colorectal carcinomatosis before a curative procedure. Peritoneal carcinomatosis (PC) from colorectal cancer may be treated with a curative intent by cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). The role of perioperative systemic chemotherapy for this particular metastatic disease remains unclear. One hundred twenty patients with PC from colorectal cancer were consecutively treated by 131 procedures combining CRS with HIPEC. The response to neoadjuvant systemic chemotherapy was assessed on data from previous explorative surgery and/or radiological imaging. Ninety patients (75%) were treated with neoadjuvant systemic chemotherapy in whom 32 (36%) were considered to have responded, 19 (21%) had stable disease, and 19 (21%) developed diseases progression. Response could not be evaluated in 20 patients (22%). On univariate analysis, the use of neoadjuvant systemic chemotherapy had a significant positive prognostic influence (P = 0.042). On multivariate analysis, the completeness of CRS and the use of adjuvant systemic chemotherapy were the only significant prognostic factors (P systemic chemotherapy had no significant prognostic impact with median survival of 31.4 months in patients showing disease progression. In patients with PC from colorectal cancer without extraperitoneal metastases, failure of neoadjuvant systemic chemotherapy should not constitute an absolute contraindication to a curative procedure combining CRS and HIPEC.

  9. Approach for investigations of progressive fatigue damage in 3D in fibre composites using X-ray tomography

    DEFF Research Database (Denmark)

    Mikkelsen, Lars Pilgaard; Jespersen, Kristine Munk

    (Jespersen & Mikkelsen, 2016) has been performed. An ex-situ study where it has been important to design a good gripping strategy inside the scanning machine. Doing this, it has been possible to scan the same region multiple times. Thereby, a progressive fatigue damage evolution has been observed.......Understanding fatigue damage initiation and evolution in the load carrying laminates inside wind turbine blade plays a key factor designing longer and lighter turbine blades. Thereby, it is possible to lower the Cost of Energy for the wind energy based electricity production either by simply...... building larger wind turbines or by upgrading existing turbines for lower wind classes’ . In the presented work, a Zeiss Xradia Versa 520 scanner has been used in connection with ex-situ fatigue testing with the purpose of identifying fibre failure during the fatigue loading. The load carrying laminates...

  10. Combined macroscopic and microscopic approach to the fracture of metals. Technical progress report, July 1975--June 1976

    International Nuclear Information System (INIS)

    Gurland, J.; Rice, J.R.; Asaro, R.J.; Needleman, A.

    1976-07-01

    Major studies have been started on (1) The conditions governing the localization of plastic flow at the onset of rupture. Specific calculations of critical conditions for a number of material models have been made possible through a theoretical framework by which localization is formulated as a constitutive instability, in the form of a bifurcation into a localized mode from a state of previously homogeneous deformation, and (2) The strength of interfaces with and without the presence of dissolved segregants. Criteria for brittle vs. ductile response of an interface were developed on the basis of dislocation mechanisms and thermodynamic relations, and applied to hydrogen embrittlement. Further progress has been achieved in the analysis of stress and deformation at a crack tip by the application of the large-strain elastic-plastic finite element program developed over the last two years. Work has continued on particle and sub-boundary strengthening in steels and an experimental study of fracture initiation at particles was begun

  11. A Diagnostic Approach for Rodent Progressive Cardiomyopathy and Like Lesions in Toxicology Studies up to 28 Days in the Sprague Dawley Rat (Part 2 of 2).

    Science.gov (United States)

    Hailey, James R; Maleeff, Beverly E; Thomas, Heath C; Pearse, Gail; Klapwijk, Jan C; Cristofori, Patrizia G; Berridge, Brian; Kimbrough, Carie L; Parker, George A; Morton, Daniel; Elmore, Susan; Hardisty, Jerry F; Dybdal, Noel O; Rehagen, David A; Fikes, James D; Lamb, Martin; Biddle, Kathleen; Buetow, Bernard S; Carreira, Vinicius; Nyska, Abraham; Tripathi, Niraj K; Workman, Heather C; Bienvenu, Jean-Guy; Brees, Ingrid; Turk, James R; Adler, Rick R

    2017-12-01

    To test the diagnostic approach described in part 1 of this article, 2 exercises were completed by pathologists from multiple companies/agencies. Pathologist's examination of whole slide image (WSI) heart sections from rats using personal diagnostic approaches (exercise #1) corroborated conclusions from study #1. Using the diagnostic approach described in part 1, these pathologists examined the same WSI heart sections (exercise #2) to determine whether that approach increased consistency of diagnosis of rodent progressive cardiomyopathy (PCM) lesions. In exercise #2, there was improved consistency of categorization of small borderline morphologies and mild lesions, but a decrement in consistency of categorizing minimal lesions. Exercises 1 and 2 suggest the described diagnostic approach is representative of that in use by the majority of toxicologic pathologists across companies/agencies and that application by all may improve diagnostic consistency of PCM/like lesions. Additionally, a criterion of approximately 5% heart section involvement is suggested for separating mild from moderate or greater severity. While evidence is not absolute, until further investigation shows otherwise, microscopic changes resembling PCM, but located in the epicardial and subepicardial region of the right ventricle, may be considered as part of the spectrum of PCM.

  12. Assessment on the Prevention of Progression by Rosiglitazone on Atherosclerosis in diabetes patients with Cardiovascular History (APPROACH): study design and baseline characteristics.

    Science.gov (United States)

    Ratner, Robert E; Cannon, Christopher P; Gerstein, Hertzel C; Nesto, Richard W; Serruys, Patrick W; Van Es, Gerrit-Anne; Kolatkar, Nikheel S; Kravitz, Barbara G; Zalewski, Andrew; Fitzgerald, Peter J

    2008-12-01

    Rosiglitazone, a thiazolidinedione, has effects on insulin sensitivity and cardiovascular risk factors that may favorably impact the progression of coronary atherosclerosis. APPROACH is a double-blind randomized clinical trial comparing the effects of the insulin sensitizer rosiglitazone with the insulin secretagogue glipizide on the progression of coronary atherosclerosis. Patients with type 2 diabetes and coronary artery disease undergoing clinically indicated coronary angiography or percutaneous coronary intervention are randomized to receive rosiglitazone or glipizide for 18 months using a titration algorithm designed to provide comparable glycemic control between treatment groups. The primary end point is change in percent atheroma volume from baseline to study completion in a nonintervened coronary artery, as measured by intravascular ultrasound. Cardiovascular events are adjudicated by an end point committee. A total of 672 patients were randomized. The mean age was 61 years, hemoglobin A(1c) (HbA(1c)) 7.2%, body mass index 29.5 kg/m(2), and median duration of diabetes 4.8 years. At baseline, approximately half of the participants were receiving oral antidiabetic monotherapy (53.9%) with 27.5% receiving dual combination therapy and 17.9% treated with diet and exercise alone. Approximately two thirds of the participants (68%) had dyslipidemia, 79.9% hypertension, and 24% prior myocardial infarction. APPROACH has fully enrolled a high-risk patient population and will compare the glucose-independent effects of rosiglitazone and glipizide on the progression of coronary atherosclerosis, as well as provide additional data on the cardiovascular safety of rosiglitazone in patients with type 2 diabetes and coronary artery disease.

  13. Role of gut microbiota and oxidative stress in the progression of non-alcoholic fatty liver disease to hepatocarcinoma: Current and innovative therapeutic approaches

    Directory of Open Access Journals (Sweden)

    Antonella Borrelli

    2018-05-01

    Full Text Available Non-alcoholic fatty liver disease (NAFLD represents the most common chronic liver disease in industrialized countries. NAFLD progresses through the inflammatory phase of non-alcoholic steatohepatitis (NASH to fibrosis and cirrhosis, with some cases developing liver failure or hepatocellular carcinoma (HCC. Liver biopsy remains the gold standard approach to a definitive diagnosis of NAFLD and the distinction between simple steatosis and NASH. The pathogenesis of NASH is still not clear. Several theories have been proposed ranging from the “Two Hit Theory” to the “Multiple Hit Theory”. However, the general consensus is that the gut microbiota, oxidative stress, and mitochondrial damage play key roles in the pathogenesis of NASH. The interaction between the gut epithelia and some commensal bacteria induces the rapid generation of reactive oxygen species (ROS. The main goal of any therapy addressing NASH is to reverse or prevent progression to liver fibrosis/cirrhosis. This problem represents the first “Achilles’ heel” of the new molecules being evaluated in most ongoing clinical trials. The second is the inability of these molecules to reach the mitochondria, the primary sites of energy production and ROS generation. Recently, a variety of non-pharmacological and pharmacological treatment approaches for NASH have been evaluated including vitamin E, the thiazolidinediones, and novel molecules related to NASH pathogenesis (including obeticholic acid and elafibranor. Recently, a new isoform of human manganese superoxide dismutase (MnSOD was isolated and obtained in a synthetic recombinant form designated rMnSOD. This protein has been shown to be a powerful antioxidant capable of mediating ROS dismutation, penetrating biological barriers via its uncleaved leader peptide, and reducing portal hypertension and fibrosis in rats affected by liver cirrhosis. Based on these distinctive characteristics, it can be hypothesized that this novel

  14. Promising approaches to circumvent the blood-brain barrier: progress, pitfalls and clinical prospects in brain cancer.

    Science.gov (United States)

    Papademetriou, Iason T; Porter, Tyrone

    2015-01-01

    Brain drug delivery is a major challenge for therapy of central nervous system (CNS) diseases. Biochemical modifications of drugs or drug nanocarriers, methods of local delivery, and blood-brain barrier (BBB) disruption with focused ultrasound and microbubbles are promising approaches which enhance transport or bypass the BBB. These approaches are discussed in the context of brain cancer as an example in CNS drug development. Targeting to receptors enabling transport across the BBB offers noninvasive delivery of small molecule and biological cancer therapeutics. Local delivery methods enable high dose delivery while avoiding systemic exposure. BBB disruption with focused ultrasound and microbubbles offers local and noninvasive treatment. Clinical trials show the prospects of these technologies and point to challenges for the future.

  15. Synthesis of new water-soluble metal-binding polymers: Combinatorial chemistry approach. 1998 annual progress report

    International Nuclear Information System (INIS)

    Kurth, M.J.; Miller, R.B.; Sawan, S.; Smith, B.F.

    1998-01-01

    '(1) Develop rapid discovery and optimization approaches to new water-soluble chelating polymers for use in Polymer Filtration (PF) systems, and (2) evaluate the concept of using water and organic soluble polymers as new solid supports for combinatorial synthesis. Polymer Filtration (PF), which uses water-soluble metal-binding polymers to sequester metal ions in dilute solution with ultrafiltration (UF) to separate the polymers, is a new technology to selectively remove or recover hazardous and valuable metal ions. Future directions in PF must include rapid development, testing, and characterization of new metal-binding polymers. Thus, the authors are building upon and adapting the combinatorial chemistry approach developed for rapid molecule generation for the drug industry to the rapid development of new chelating polymers. The authors have focused on four areas including the development of: (1) synthetic procedures, (2) small ultrafiltration equipment compatible with organic- and aqueous-based combinatorial synthesis, (3) rapid assay techniques, and (4) polymer characterization techniques.'

  16. Assessment of Chinese Students’ Progression and Perceptions in Blended Team-Based Learning Approach at an International College in China

    OpenAIRE

    Malekigorji, Maryam; Corbett, Dan; Rooney, David; Hanna, Lezley-Anne; Hall, Maurice

    2018-01-01

    Blended team-based learning (TBL) as a major component of an undergraduate course was implemented at a UK joint college in China. The core components of TBL were introduced in the course for Chinese students and their academic performance and course evaluation data with blended TBL approach was compared with solely flipped classroom and traditional lecture-based courses. Students’ perceptions regarding traditional learning and TBL were investigated and compared through the use of an online pe...

  17. Candidate soil indicators for monitoring the progress of constructed wetlands toward a natural state: a statistical approach

    Science.gov (United States)

    Stapanian, Martin A.; Adams, Jean V.; Fennessy, M. Siobhan; Mack, John; Micacchion, Mick

    2013-01-01

    A persistent question among ecologists and environmental managers is whether constructed wetlands are structurally or functionally equivalent to naturally occurring wetlands. We examined 19 variables collected from 10 constructed and nine natural emergent wetlands in Ohio, USA. Our primary objective was to identify candidate indicators of wetland class (natural or constructed), based on measurements of soil properties and an index of vegetation integrity, that can be used to track the progress of constructed wetlands toward a natural state. The method of nearest shrunken centroids was used to find a subset of variables that would serve as the best classifiers of wetland class, and error rate was calculated using a five-fold cross-validation procedure. The shrunken differences of percent total organic carbon (% TOC) and percent dry weight of the soil exhibited the greatest distances from the overall centroid. Classification based on these two variables yielded a misclassification rate of 11% based on cross-validation. Our results indicate that % TOC and percent dry weight can be used as candidate indicators of the status of emergent, constructed wetlands in Ohio and for assessing the performance of mitigation. The method of nearest shrunken centroids has excellent potential for further applications in ecology.

  18. Interleukin-6 promotes systemic lupus erythematosus progression with Treg suppression approach in a murine systemic lupus erythematosus model.

    Science.gov (United States)

    Mao, Xiaoli; Wu, Yunyun; Diao, Huitian; Hao, Jianlei; Tian, Gaofei; Jia, Zhenghu; Li, Zheng; Xiong, Sidong; Wu, Zhenzhou; Wang, Puyue; Zhao, Liqing; Yin, Zhinan

    2014-11-01

    Our aim is to reveal the role of interleukin 6 (IL-6) in the pathogenesis of systemic lupus erythematosus (SLE) in a murine model of SLE. Normal female C57BL/6 mice were immunized with syngeneic-activated lymphocyte-derived DNA (ALD-DNA) to induce SLE. Non-immunized mice were used as control. SLE-associated markers, including anti-double-stranded DNA (anti-dsDNA) Abs, urine protein, and kidney histopathology, were assayed to ensure the induction of the disease. Compared with control mice, ALD-DNA immunized mice exhibited high levels of anti-dsDNA Abs, IL-6 expression in vivo and in vitro. We also found that IL-6 knockout (IL-6KO) mice were resistant to ALD-DNA-induced SLE. The activation of CD4(+) T cells in immunized IL-6KO mice was lower than in immunized wild-type (Wt) mice. Intracellular cytokine staining showed that Foxp3 expression in immunized IL-6KO mice was higher than in immunized Wt mice, which might be associated with the disease severity. We further discovered that ALD-DNA-stimulated dendritic cells supernatants could result in higher IL-6 and TNF-α expression and could suppress Foxp3 expression. In addition, blocking IL-6 could up-regulate Foxp3 expression. Therefore, our findings show that IL-6 promotes the progression of SLE via suppressing Treg differentiation.

  19. a New Approach for Progressive Dense Reconstruction from Consecutive Images Based on Prior Low-Density 3d Point Clouds

    Science.gov (United States)

    Lari, Z.; El-Sheimy, N.

    2017-09-01

    In recent years, the increasing incidence of climate-related disasters has tremendously affected our environment. In order to effectively manage and reduce dramatic impacts of such events, the development of timely disaster management plans is essential. Since these disasters are spatial phenomena, timely provision of geospatial information is crucial for effective development of response and management plans. Due to inaccessibility of the affected areas and limited budget of first-responders, timely acquisition of the required geospatial data for these applications is usually possible only using low-cost imaging and georefencing sensors mounted on unmanned platforms. Despite rapid collection of the required data using these systems, available processing techniques are not yet capable of delivering geospatial information to responders and decision makers in a timely manner. To address this issue, this paper introduces a new technique for dense 3D reconstruction of the affected scenes which can deliver and improve the needed geospatial information incrementally. This approach is implemented based on prior 3D knowledge of the scene and employs computationally-efficient 2D triangulation, feature descriptor, feature matching and point verification techniques to optimize and speed up 3D dense scene reconstruction procedure. To verify the feasibility and computational efficiency of the proposed approach, an experiment using a set of consecutive images collected onboard a UAV platform and prior low-density airborne laser scanning over the same area is conducted and step by step results are provided. A comparative analysis of the proposed approach and an available image-based dense reconstruction technique is also conducted to prove the computational efficiency and competency of this technique for delivering geospatial information with pre-specified accuracy.

  20. Synthesis of new water-soluble metal-binding polymers: Combinatorial chemistry approach. 1997 mid-year progress report

    International Nuclear Information System (INIS)

    Smith, B.F.

    1997-01-01

    'The first objective of this research is to develop rapid discovery and optimization approaches to new water-soluble chelating polymers. A byproduct of the development approach will be the new, selective, and efficient metal-binding agents. The second objective is to evaluate the concept of using water and organic soluble polymers as new solid supports for combinatorial synthesis. The technology under development, Polymer Filtration (PF), is a technique to selectively remove or recover hazardous and valuable metal ions and radionuclides from various dilute aqueous streams. Not only can this technology be used to remediate contaminated soils and solid surfaces and treat aqueous wastes, it can also be incorporated into facilities as a pollution prevention and waste minimization technology. Polymer Filtration uses water-soluble metal-binding polymers to sequester metal ions in dilute solution. The water-soluble polymers have a sufficiently large molecular size that they can be separated and concentrated using commercial ultrafiltration technology. Water, small organic molecules, and unbound metals pass freely through the ultrafiltration membrane while concentrating the metal-binding polymer. The polymers can then be reused by changing the solution conditions to release the metal ions. The metal-ions are recovered in concentrated form for recycle or disposal using a diafiltration process. The water-soluble polymer can be recycled for further aqueous-stream processing. To advance Polymer Filtration technology to the selectivity levels required for DOE needs. fixture directions in Polymer Filtration must include rapid development, testing, and characterization of new metal-binding polymers. The development of new chelating molecules can be equated to the process of new drugs or new materials discovery. Thus, the authors want to build upon and adapt the combinatorial chemistry approaches developed for rapid molecule generation for the drug industry to the rapid

  1. Facilitating progress in health behaviour theory development and modification: the reasoned action approach as a case study.

    Science.gov (United States)

    Head, Katharine J; Noar, Seth M

    2014-01-01

    This paper explores the question: what are barriers to health behaviour theory development and modification, and what potential solutions can be proposed? Using the reasoned action approach (RAA) as a case study, four areas of theory development were examined: (1) the theoretical domain of a theory; (2) tension between generalisability and utility, (3) criteria for adding/removing variables in a theory, and (4) organisational tracking of theoretical developments and formal changes to theory. Based on a discussion of these four issues, recommendations for theory development are presented, including: (1) the theoretical domain for theories such as RAA should be clarified; (2) when there is tension between generalisability and utility, utility should be given preference given the applied nature of the health behaviour field; (3) variables should be formally removed/amended/added to a theory based on their performance across multiple studies and (4) organisations and researchers with a stake in particular health areas may be best suited for tracking the literature on behaviour-specific theories and making refinements to theory, based on a consensus approach. Overall, enhancing research in this area can provide important insights for more accurately understanding health behaviours and thus producing work that leads to more effective health behaviour change interventions.

  2. Progressivity Enhanced

    Directory of Open Access Journals (Sweden)

    Marko Hren

    2013-09-01

    Full Text Available Rather than a scientific text, the author contributes a concise memorandum from the originator of the idea who has managed the campaign for the conversion of the military barracks into a creative cluster between 1988 and 2002, when he parted ways with Metelkova due to conflicting views on the center’s future. His views shed light on a distant period of time from a perspective of a participant–observer. The information is abundantly supported by primary sources, also available online. However, some of the presented hypotheses are heavily influenced by his personal experiences of xenophobia, elitism, and predatorial behavior, which were already then discernible on the so-called alternative scene as well – so much so that they obstructed the implementation of progressive programs. The author claims that, in spite of the substantially different reality today, the myths and prejudices concerning Metelkova must be done away with in order to enhance its progressive nature. Above all, the paper calls for an objective view on internal antagonisms, mainly originating in deep class divisions between the users. These make a clear distinction between truly marginal ndividuals and the overambitious beau-bourgeois, as the author labels the large part of users of Metelkova of »his« time. On these grounds, he argues for a robust approach to ban all forms of xenophobia and self-ghettoization.

  3. Progress in national-scale landslide susceptibility mapping in Romania using a combined statistical-heuristical approach

    Science.gov (United States)

    Bălteanu, Dan; Micu, Mihai; Malet, Jean-Philippe; Jurchescu, Marta; Sima, Mihaela; Kucsicsa, Gheorghe; Dumitrică, Cristina; Petrea, Dănuţ; Mărgărint, Ciprian; Bilaşco, Ştefan; Văcăreanu, Radu; Georgescu, Sever; Senzaconi, Francisc

    2017-04-01

    Landslide processes represent a very widespread geohazard in Romania, affecting mainly the hilly and plateau regions as well as the mountain sectors developed on flysch formations. Two main projects provided the framework for improving the existing national landslide susceptibility map (Bălteanu et al. 2010): the ELSUS (Pan-European and nation-wide landslide susceptibility assessment, EC-CERG) and the RO-RISK (Disaster Risk Evaluation at National Level, ESF-POCA) projects. The latter one, a flagship project aiming at strengthening risk prevention and management in Romania, focused on a national-level evaluation of the main risks in the country including landslides. The strategy for modeling landslide susceptibility was designed based on the experience gained from continental and national level assessments conducted in the frame of the International Programme on Landslides (IPL) project IPL-162, the European Landslides Expert Group - JRC and the ELSUS project. The newly proposed landslide susceptibility model used as input a reduced set of landslide conditioning factor maps available at scales of 1:100,000 - 1:200,000 and consisting of lithology, slope angle and land cover. The input data was further differentiated for specific natural environments, defined here as morpho-structural units in order to incorporate differences induced by elevation (vertical climatic zonation), morpho-structure as well as neotectonic features. In order to best discern the specific landslide conditioning elements, the analysis has been carried out for one single process category, namely slides. The existence of a landslide inventory covering the whole country's territory ( 30,000 records, Micu et al. 2014), although affected by incompleteness and lack of homogeneity, allowed for the application of a semi-quantitative, mixed statistical-heuristical approach having the advantage of combining the objectivity of statistics with expert-knowledge in calibrating class and factor weights. The

  4. Establishing a cause and effect relationship for ambient ozone exposure and tree growth in the forest: Progress and an experimental approach

    International Nuclear Information System (INIS)

    Manning, William J.

    2005-01-01

    Much has been written about the effects of ambient ozone on tree growth. Cause and effect has been established with seedlings in chambers. Results from multi-year studies with older tree seedlings, in open-top chambers, have been inconclusive, due to chamber effects. Extrapolation of results from chambers to trees in the forest is not possible. Predictive models for forest tree growth reductions caused by ozone have been developed, but not verified. Dendrochronological methods have been used to establish correlations between radial growth reductions in forest trees and ambient ozone exposure. The protective chemical ethylenediurea (EDU) has been used to protect tree seedlings from ozone injury. An experimental approach is advocated here that utilizes forest trees selected for sensitivity and non-sensitivity to ozone, dendrochronological methods, the protective chemical EDU, and monitoring data for ambient ozone, stomatal conductance, soil moisture potential, air temperature, PAR, etc. in long-term investigations to establish cause and effect relationships. - Progress is reviewed and an experimental approach is proposed to demonstrate a cause and effect relationship for ambient ozone and forest tree growth

  5. Horse species symposium: a novel approach to monitoring pathogen progression during uterine and placental infection in the mare using bioluminescence imaging technology and lux-modified bacteria.

    Science.gov (United States)

    Ryan, P L; Christiansen, D L; Hopper, R M; Walters, F K; Moulton, K; Curbelo, J; Greene, J M; Willard, S T

    2011-05-01

    Uterine and placental infections are the leading cause of abortion, stillbirth, and preterm delivery in the mare. Whereas uterine and placental infections in women have been studied extensively, a comprehensive examination of the pathogenic processes leading to this unsatisfactory pregnancy outcome in the mare has yet to be completed. Most information in the literature relating to late-term pregnancy loss in mares is based on retrospective studies of clinical cases submitted for necropsy. Here we report the development and application of a novel approach, whereby transgenically modified bacteria transformed with lux genes of Xenorhabdus luminescens or Photorhabdus luminescens origin and biophotonic imaging are utilized to better understand pathogen-induced preterm birth in late-term pregnant mares. This technology uses highly sensitive bioluminescence imaging camera systems to localize and monitor pathogen progression during tissue invasion by measuring the bioluminescent signatures emitted by the lux-modified pathogens. This method has an important advantage in that it allows for the potential tracking of pathogens in vivo in real time and over time, which was hitherto impossible. Although the application of this technology in domestic animals is in its infancy, investigators were successful in identifying the fetal lungs, sinuses, nares, urinary, and gastrointestinal systems as primary tissues for pathogen invasion after experimental infection of pregnant mares with lux-modified Escherichia coli. It is important that pathogens were not detected in other vital organs, such as the liver, brain, and cardiac system. Such precision in localizing sites of pathogen invasion provides potential application for this novel approach in the development of more targeted therapeutic interventions for pathogen-related diseases in the equine and other domestic species.

  6. Integrated approach towards the application of horizontal wells to improve waterflooding performance. Annual progress report, January 1, 1996--December 31, 1996

    Energy Technology Data Exchange (ETDEWEB)

    Kelkar, M.; Liner, C.; Kerr, D.

    1997-01-01

    This annual report describes the progress during the fourth year of the project on {open_quotes}Integrated Approach Towards the Application of Horizontal Wells to Improve Waterflooding Performance{close_quotes}. The project involves using an integrated approach to characterize the reservoir followed by proposing an appropriate reservoir management strategy to improve the field performance. In the first stage of the project, the type of data we integrated include cross borehole seismic surveys, geological interpretation based on the logs and the cores, and the engineering information. In contrast, during the second stage of the project, we intend to use only conventional data to construct the reservoir description. This report covers the results of the implementation from the first stage of the project. It also discusses the work accomplished so far for the second stage of the project. The production from the Self Unit (location of Stage 1) has sustained an increase of 30 bbls/day over a year with an additional increase anticipated with further implementation. We have collected available core, log and production data from Section 16 in the Berryhill Glenn Unit and have finished the geological description. Based on the geological description and the associated petrophysical properties, we have developed a new indexing procedure for identifying the areas with the most potential. We are also investigating an adjoining tract formerly operated by Chevron where successful miceller-polymer flood was conducted. This will help us in evaluating the reasons for the success of the flood. Armed with this information, we will conduct a detailed geostatistical and flow simulation study and recommend the best reservoir management plan to improve the recovery of the field.

  7. A community-based approach to non-communicable chronic disease management within a context of advancing universal health coverage in China: progress and challenges.

    Science.gov (United States)

    Xiao, Nanzi; Long, Qian; Tang, Xiaojun; Tang, Shenglan

    2014-01-01

    Paralleled with the rapid socio-economic development and demographic transition, an epidemic of non-communicable chronic diseases (NCDs) has emerged in China over the past three decades, resulting in increased disease and economic burdens. Over the past decade, with a political commitment of implementing universal health coverage, China has strengthened its primary healthcare system and increased investment in public health interventions. A community-based approach to address NCDs has been acknowledged and recognized as one of the most cost-effective solutions. Community-based strategies include: financial and health administrative support; social mobilization; community health education and promotion; and the use of community health centers in NCD detection, diagnosis, treatment, and patient management. Although China has made good progress in developing and implementing these strategies and policies for NCD prevention and control, many challenges remain. There are a lack of appropriately qualified health professionals at grass-roots health facilities; it is difficult to retain professionals at that level; there is insufficient public funding for NCD care and management; and NCD patients are economically burdened due to limited benefit packages covering NCD treatment offered by health insurance schemes. To tackle these challenges we propose developing appropriate human resource policies to attract greater numbers of qualified health professionals at the primary healthcare level; adjusting the service benefit packages to encourage the use of community-based health services; and increase government investment in public health interventions, as well as investing more on health insurance schemes.

  8. A Carbon Monitoring System Approach to US Coastal Wetland Carbon Fluxes: Progress Towards a Tier II Accounting Method with Uncertainty Quantification

    Science.gov (United States)

    Windham-Myers, L.; Holmquist, J. R.; Bergamaschi, B. A.; Byrd, K. B.; Callaway, J.; Crooks, S.; Drexler, J. Z.; Feagin, R. A.; Ferner, M. C.; Gonneea, M. E.; Kroeger, K. D.; Megonigal, P.; Morris, J. T.; Schile, L. M.; Simard, M.; Sutton-Grier, A.; Takekawa, J.; Troxler, T.; Weller, D.; Woo, I.

    2015-12-01

    Despite their high rates of long-term carbon (C) sequestration when compared to upland ecosystems, coastal C accounting is only recently receiving the attention of policy makers and carbon markets. Assessing accuracy and uncertainty in net C flux estimates requires both direct and derived measurements based on both short and long term dynamics in key drivers, particularly soil accretion rates and soil organic content. We are testing the ability of remote sensing products and national scale datasets to estimate biomass and soil stocks and fluxes over a wide range of spatial and temporal scales. For example, the 2013 Wetlands Supplement to the 2006 IPCC GHG national inventory reporting guidelines requests information on development of Tier I-III reporting, which express increasing levels of detail. We report progress toward development of a Carbon Monitoring System for "blue carbon" that may be useful for IPCC reporting guidelines at Tier II levels. Our project uses a current dataset of publically available and contributed field-based measurements to validate models of changing soil C stocks, across a broad range of U.S. tidal wetland types and landuse conversions. Additionally, development of biomass algorithms for both radar and spectral datasets will be tested and used to determine the "price of precision" of different satellite products. We discuss progress in calculating Tier II estimates focusing on variation introduced by the different input datasets. These include the USFWS National Wetlands Inventory, NOAA Coastal Change Analysis Program, and combinations to calculate tidal wetland area. We also assess the use of different attributes and depths from the USDA-SSURGO database to map soil C density. Finally, we examine the relative benefit of radar, spectral and hybrid approaches to biomass mapping in tidal marshes and mangroves. While the US currently plans to report GHG emissions at a Tier I level, we argue that a Tier II analysis is possible due to national

  9. Progress Report

    DEFF Research Database (Denmark)

    Duer, Karsten

    1999-01-01

    Progress report describing the work carried out by the Danish participant in the ALTSET project in the period January 1999 to July 1999.......Progress report describing the work carried out by the Danish participant in the ALTSET project in the period January 1999 to July 1999....

  10. Progress Report

    Science.gov (United States)

    2018-05-16

    This report summarizes the annual progress of EPA’s Clean Air Markets Programs such as the Acid Rain Program (ARP) and the Cross-State Air Pollution Rule (CSAPR). EPA systematically collects data on emissions, compliance, and environmental effects, these data are highlighted in our Progress Reports.

  11. A whole-brain computational modeling approach to explain the alterations in resting-state functional connectivity during progression of Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    Murat Demirtaş

    2017-01-01

    Full Text Available Alzheimer's disease (AD is the most common dementia with dramatic consequences. The research in structural and functional neuroimaging showed altered brain connectivity in AD. In this study, we investigated the whole-brain resting state functional connectivity (FC of the subjects with preclinical Alzheimer's disease (PAD, mild cognitive impairment due to AD (MCI and mild dementia due to Alzheimer's disease (AD, the impact of APOE4 carriership, as well as in relation to variations in core AD CSF biomarkers. The synchronization in the whole-brain was monotonously decreasing during the course of the disease progression. Furthermore, in AD patients we found widespread significant decreases in functional connectivity (FC strengths particularly in the brain regions with high global connectivity. We employed a whole-brain computational modeling approach to study the mechanisms underlying these alterations. To characterize the causal interactions between brain regions, we estimated the effective connectivity (EC in the model. We found that the significant EC differences in AD were primarily located in left temporal lobe. Then, we systematically manipulated the underlying dynamics of the model to investigate simulated changes in FC based on the healthy control subjects. Furthermore, we found distinct patterns involving CSF biomarkers of amyloid-beta (Aβ1−42 total tau (t-tau and phosphorylated tau (p-tau. CSF Aβ1−42 was associated to the contrast between healthy control subjects and clinical groups. Nevertheless, tau CSF biomarkers were associated to the variability in whole-brain synchronization and sensory integration regions. These associations were robust across clinical groups, unlike the associations that were found for CSF Aβ1−42. APOE4 carriership showed no significant correlations with the connectivity measures.

  12. Progressive Business

    DEFF Research Database (Denmark)

    Christiansen, Christian O.

    2016-01-01

    Guest Post to the Society for U.S. Intellectual History Blog. Brief introduction to the book Progressive Business: An Intellectual History of the Role of Business in American Society, Oxford U.P., 2015.......Guest Post to the Society for U.S. Intellectual History Blog. Brief introduction to the book Progressive Business: An Intellectual History of the Role of Business in American Society, Oxford U.P., 2015....

  13. Feasibility of a novel approach for fast, economical determination of radiation damage in nuclear reactor cores. Progress report, [November 1, 1993--October 31, 1994

    International Nuclear Information System (INIS)

    Was, G.S.

    1994-01-01

    Progress has been made in several areas in the second year of grant activity. This includes radiation induced segregation (modeling and experiment), deformation of the irradiated microstructure and stress corrosion cracking of irradiated microstructures

  14. Scientific Progress in Strategic Management

    DEFF Research Database (Denmark)

    Foss, Nicolai Juul

    Does the RBV represent a case of scientific progress? And has it emerged as the dominant approach to the analysis of competitive advantage for this reason? Conventional criteria for scientific progress, notably those of the growth of knowledge literature, are not particularly helpful for understa...

  15. Some Approaches to the Accounting and Analysis of the Impact of Scientific and Technological Progress in the Harrod-Domar Economic Growth Model

    Directory of Open Access Journals (Sweden)

    Dilenko Viktor O.

    2016-11-01

    Full Text Available The paper presents methods for the accounting of autonomous and induced scientific and technological progress in the Harrod-Domar model of economic dynamics that imply determining the incremental capital/output ratio of the model in the form of special functions of time. As part of the received version of the Harrod-Domar model, on the basis of conditional data there conducted a numerical study of some aspects of the impact of parameters of scientific and technological progress and the initial state of the economy being modeled on peculiarities of corresponding trajectories of its dynamics. A simple economic and mathematical problem of determining an optimal value of investments in the implementation of the induced STP is formulated, and content interpretation of the obtained solution is carried out. Possible directions of development of the obtained results may be associated with the application of the proposed modification of the Harrod-Domar model to build and analyze mathematical models of optimal economic growth in view of the induced STP, as well as with the prospective use of these results to improve dynamic models of the Leontief type in terms of considering innovation processes (scientific and technical progress of various kinds.

  16. Measuring progress

    DEFF Research Database (Denmark)

    Wahlberg, Ayo

    2007-01-01

    In recent years, sociological examinations of genetics, therapeutic cloning, neuroscience and tissue engineering have suggested that 'life itself' is currently being transformed through technique with profound implications for the ways in which we understand and govern ourselves and others...... in much the same way that mortality rates, life expectancy or morbidity rates can. By analysing the concrete ways in which human progress has been globally measured and taxonomised in the past two centuries or so, I will show how global stratifications of countries according to their states...

  17. Recent progress in microcalorimetry

    CERN Document Server

    Calvet, E; Skinner, H A

    2013-01-01

    Recent Progress in Microcalorimetry focuses on the methodologies, processes, and approaches involved in microcalorimetry, as well as heat flow, temperature constancy, and chemistry of alumina and cements.The selection first offers information on the different types of calorimeters; measurement of the heat flow between the calorimeter and jacket boundaries by means of a thermoelectric pile; and constructional details of the microcalorimeter. Discussions focus on classification of calorimeters, use of thermoelectric piles as thermometers, correct measurement of heat flow from a calorimeter conta

  18. Progress report

    International Nuclear Information System (INIS)

    Brumovsky, M.

    1979-01-01

    Progress Report, covering the period up to the end of 1979 year, was sent to the IAEA according to the research agreement No. 1971 /CF. This work covered the following fields: preparation and dummy irradiation experiments with a new experimental capsule of ''CHOUCA-M'' type; measurement of temperature fields and design of specimen holders; measurement of neutron energy spectrum in the irradiation place in our experimental reactor of VVR-S type (Nuclear Research Institute) using a set of activation detectors; unification and calibration of the measurement of neutron fluence with the use of Fe, Cu, Mn-Mg and Co-Al monitors; development and improvement of the measuring apparatus and technique for the dynamic testing of pre-cracked specimens with determination of dynamic parameters of fracture mechanics; preparation and manufacture of testing specimens from the Japanese steels - forging, plate and weld metal; preparation of the irradiation capsule for assembling

  19. Sport Progressions.

    Science.gov (United States)

    Clumpner, Roy A.

    This book, which is primarily for secondary physical education teachers, presents a sequential approach to teaching skills that are essential to eight sports. The activities and lead-up games included in the book put beginning students directly into game-like situations where they can practice skills. Each chapter begins with a background of the…

  20. Progress in pulsed power fusion

    Energy Technology Data Exchange (ETDEWEB)

    Quintenz, J P; Adams, R G; Bailey, J E [Sandia Labs., Albuquerque, NM (United States); and others

    1997-12-31

    Pulsed power offers an efficient, high energy, economical source of x-rays for inertial confinement fusion (ICF) research. Two main approaches to ICF driven with pulsed power accelerators are pursued: intense light ion beams and z-pinches. Recent progress in each approach and plans for future development is described. (author). 2 figs., 10 refs.

  1. Progress in pulsed power fusion

    International Nuclear Information System (INIS)

    Quintenz, J.P.; Adams, R.G.; Bailey, J.E.

    1996-01-01

    Pulsed power offers an efficient, high energy, economical source of x-rays for inertial confinement fusion (ICF) research. Two main approaches to ICF driven with pulsed power accelerators are pursued: intense light ion beams and z-pinches. Recent progress in each approach and plans for future development is described. (author). 2 figs., 10 refs

  2. The structural response and manner of progressive collapse in RC buildings under the blast and Provide approaches to retrofitting columns against blast

    Directory of Open Access Journals (Sweden)

    GholamReza Havaei

    2017-05-01

    Full Text Available In accidents caused by explosion, the initial damage is usually caused by direct hit blast that it causes damage and serious destruction of structural components. In this state, the collapse of structural components and the subsequent progressive collapse may cause an increase in damages and eventually collapse of the structure. On the other hand, observations show that most of these buildings designed and built without consideration of their vulnerability to such events. In this study, global and local response of reinforced concrete buildings and their damages evaluated against explosion. First the global stability of building using SAP2000 is evaluated against explosion and then the amount and behaviour of damages in The key structural components of the building after the explosion is investigated using LS DYNA. The study involved four important areas in structural engineering that includes blast load determination, numerical modelling with FEM techniques, material performance under high strain rate and non-linear dynamic analysis. Two types of design methods are recommended for RC columns to provide superior residual capacities. They are RC columns detailing with additional steel reinforcement cages and a composite columns including a central structural steel core. The results showed that the use of this type of columns compared to typical RC column against explosion can have a significant impact in increasing the bearing capacity of structural components against gravity loads after the explosion.

  3. Integrated landscape-based approach of remote sensing, GIS, and physical modelling to study the hydrological connectivity of wetlands to the downstream water: progress and challenge

    Science.gov (United States)

    Yeo, I. Y.

    2015-12-01

    We report the recent progress on our effort to improve the mapping of wetland dynamics and the modelling of its functioning and hydrological connection to the downstream waters. Our study focused on the Coastal Plain of the Chesapeake Bay Watershed (CBW), the Delmarva Peninsula, where the most of wetlands in CBW are densely distributed. The wetland ecosystem plays crucial roles in improving water quality and ecological integrity for the downstream waters and the Chesapeake Bay, and headwater wetlands in the region, such as Delmarva Bay, are now subject to the legal protection under the Clean Water Rules. We developed new wetland maps using time series Landsat images and a highly accurate LiDAR map over last 30 years. These maps show the changes in surface water fraction at a 30-m grid cell at annual time scale. Using GIS, we analyse these maps to characterize changing dynamics of wetland inundation due to the physical environmental factors (e.g., weather variability, tide) and assessed the hydrological connection of wetlands to the downstream water at the watershed scale. Focusing on the two adjacent watersheds in the upper region of the Choptank River Basin, we study how wetland inundation dynamics and the hydrologic linkage of wetlands to downstream water would vary by the local hydrogeological setting and attempt to identify the key landscape factors affecting the wetland ecosystems and functioning. We then discuss the potential of using remote sensing products to improve the physical modelling of wetlands from our experience with SWAT (Soil and Water Assessment Tool).

  4. Progressive Taxation and Tax Morale

    OpenAIRE

    Philipp Doerrenberg; Andreas Peichl

    2010-01-01

    As the link between tax compliance and tax morale is found to be robust, finding the determinants of tax morale can help to understand and fight tax evasion. In this paper we analyze the effect of progressive taxation on tax morale in a cross-country approach - which has not been investigated before. Our theoretical analysis leads to two testable predictions. First, an individual's tax morale is higher, the more progressive the tax schedule is. Second, the impact of tax progressivity on tax m...

  5. An immunochemical approach to the study of DNA damage and repair: Technical progress report, August 1, 1986 to July 31, 1987

    International Nuclear Information System (INIS)

    1987-01-01

    Immunochemical methods are being developed to quantitate unique DNA base damages in x-irradiated DNA. The approach is to chemically synthesize modified nucleotides, conjugate them to protein carriers, and use the conjugates as immunogens in rabbits. Several thymine ring saturation or fragmentation products have been chosen as models for pyrimidine radiolysis products. These include thymine glycol, dihydrothymine and urea. The characterized antibodies are used to quantitate DNA damage x-irradiated in vitro and to immunochemically characterize the antibody to dihydrothymine. 12 refs., 1 fig., 1 tab

  6. Geothermal progress monitor. Progress report No. 1

    Energy Technology Data Exchange (ETDEWEB)

    1979-12-01

    Progress is reported on the following: electrical uses, direct-heat uses, drilling activities, leases, geothermal loan guarantee program, general activities, and legal, institutional, and regulatory activites. (MHR)

  7. Proactive and Progressive Approaches in Managing Obesity.

    Science.gov (United States)

    Eckel, Robert H; Bays, Harold E; Klein, Samuel; Bade Horn, Deborah

    2016-10-01

    Despite the advice clinicians have been giving patients about the importance of restricting their food intake and increasing physical activity levels, the Centers for Disease Control and Prevention (CDC) states that 78.6 million adults in the United States (US) are still obese. With these statistics in mind, this symposium provided insights on the genetic, cultural, and environmental underpinning of obesity and discussed the latest research on pharmacotherapy, surgery, and the need to individualize treatment.

  8. A Progressive Approach to Integrating Education Technology

    Science.gov (United States)

    Nemcek, Felicia

    2013-01-01

    Do you ever have the feeling that with rapidly changing technology your students are driving the bus and you are holding on for dear life? According to the author, who is the principal of the Southwest Career and Technical Academy (SWCTA) located in Las Vegas, Nevada, they feel that way more often than not. However, she and her faculty understand…

  9. Scientific progress as increasing verisimilitude.

    Science.gov (United States)

    Niiniluoto, Ilkka

    2014-06-01

    According to the foundationalist picture, shared by many rationalists and positivist empiricists, science makes cognitive progress by accumulating justified truths. Fallibilists, who point out that complete certainty cannot be achieved in empirical science, can still argue that even successions of false theories may progress toward the truth. This proposal was supported by Karl Popper with his notion of truthlikeness or verisimilitude. Popper's own technical definition failed, but the idea that scientific progress means increasing truthlikeness can be expressed by defining degrees of truthlikeness in terms of similarities between states of affairs. This paper defends the verisimilitude approach against Alexander Bird who argues that the "semantic" definition (in terms of truth or truthlikeness alone) is not sufficient to define progress, but the "epistemic" definition referring to justification and knowledge is more adequate. Here Bird ignores the crucial distinction between real progress and estimated progress, explicated by the difference between absolute (and usually unknown) degrees of truthlikeness and their evidence-relative expected values. Further, it is argued that Bird's idea of returning to the cumulative model of growth requires an implausible trick of transforming past false theories into true ones.

  10. A Learning Progression for Elementary Students' Functional Thinking

    Science.gov (United States)

    Stephens, Ana C.; Fonger, Nicole; Strachota, Susanne; Isler, Isil; Blanton, Maria; Knuth, Eric; Murphy Gardiner, Angela

    2017-01-01

    In this article we advance characterizations of and supports for elementary students' progress in generalizing and representing functional relationships as part of a comprehensive approach to early algebra. Our learning progressions approach to early algebra research involves the coordination of a curricular framework and progression, an…

  11. Progressive Pigmentary Purpura

    Science.gov (United States)

    ... Category: Share: Yes No, Keep Private Progressive Pigmentary Purpura Share | Progressive pigmentary purpura (we will call it PPP) is a group ... conditions ( Schamberg's disease , Lichenoid dermatitis of Gourgerot-Blum, purpura annularis telangiectodes of Majocchi and Lichen aureus). Schamberg's ...

  12. Primary Progressive Aphasia

    Science.gov (United States)

    ... which cause different symptoms. Semantic variant primary progressive aphasia Symptoms include these difficulties: Comprehending spoken or written ... word meanings Naming objects Logopenic variant primary progressive aphasia Symptoms include: Having difficulty retrieving words Frequently pausing ...

  13. Progressive Supranuclear Palsy: an Update.

    Science.gov (United States)

    Armstrong, Melissa J

    2018-02-17

    Progressive supranuclear palsy (PSP) is a 4R tau neuropathologic entity. While historically defined by the presence of a vertical supranuclear gaze palsy and falls in the first symptomatic year, clinicopathologic studies identify alternate presenting phenotypes. This article reviews the new PSP diagnostic criteria, diagnostic approaches, and treatment strategies. The 2017 International Parkinson and Movement Disorder Society PSP criteria outline 14 core clinical features and 4 clinical clues that combine to diagnose one of eight PSP phenotypes with probable, possible, or suggestive certainty. Evidence supports the use of select imaging approaches in the classic PSP-Richardson syndrome phenotype. Recent trials of putative disease-modifying agents showed no benefit. The new PSP diagnostic criteria incorporating the range of presenting phenotypes have important implications for diagnosis and research. More work is needed to understand how diagnostic evaluations inform phenotype assessment and identify expected progression. Current treatment is symptomatic, but tau-based therapeutics are in active clinical trials.

  14. The progressive tax

    OpenAIRE

    Estrada, Fernando

    2010-01-01

    This article describes the argumentative structure of Hayek on the relationship between power to tax and the progressive tax. It is observed throughout its work giving special attention to two works: The Constitution of Liberty (1959) and Law, Legislation and Liberty, vol3; The Political Order of Free People, 1979) Hayek describes one of the arguments most complete information bout SFP progressive tax systems (progressive tax). According to the author the history of the tax progressive system...

  15. PROGRESS IN ACUTE MYELOID LEUKEMIA

    Science.gov (United States)

    Kadia, Tapan M.; Ravandi, Farhad; O’Brien, Susan; Cortes, Jorge; Kantarjian, Hagop M.

    2014-01-01

    Significant progress has been made in the treatment of acute myeloid leukemia (AML). Steady gains in clinical research and a renaissance of genomics in leukemia have led to improved outcomes. The recognition of tremendous heterogeneity in AML has allowed individualized treatments of specific disease entities within the context of patient age, cytogenetics, and mutational analysis. The following is a comprehensive review of the current state of AML therapy and a roadmap of our approach to these distinct disease entities. PMID:25441110

  16. Progressive Multifocal Leukoencephalopathy

    Science.gov (United States)

    ... SEARCH Definition Treatment Prognosis Clinical Trials Organizations Publications Definition Progressive multifocal leukoencephalopathy (PML) is a disease of the white matter of the brain, caused by a virus infection ...

  17. Dynamically prioritized progressive transmission

    Science.gov (United States)

    Blanford, Ronald

    1992-04-01

    Retrieval of image data from a centralized database may be subject to bandwidth limitations, whether due to a low-bandwidth communications link or to contention from simultaneous accesses over a high-bandwidth link. Progressive transmission can alleviate this problem by encoding image data so that any prefix of the data stream approximates the complete image at a coarse level of resolution. The longer the prefix, the finer the resolution. In many cases, as little at 1 percent of the image data may be sufficient to decide whether to discard the image, to permit the retrieval to continue, or to restrict retrieval to a subsection of the image. Our approach treats resolution not as a fixed attribute of the image, but rather as a resource which may be allocated to portions of the image at the direction of a user-specified priority function. The default priority function minimizes error by allocating more resolution to regions of high variance. The user may also point to regions of interest requesting priority transmission. More advanced target recognition strategies may be incorporated at the user's discretion. Multispectral imagery is supported. The user engineering implications are profounded. There is immediate response to a query that might otherwise take minutes to complete. The data is transmitted in small increments so that no single user dominates the communications bandwidth. The user-directed improvement means that bandwidth is focused on interesting information. The user may continue working with the first coarse approximations while further image data is still arriving. The algorithm has been implemented in C on Sun, Silicon Graphics, and NeXT workstations, and in Lisp on a Symbolics. Transmission speeds reach as high as 60,000 baud using a Sparc or 68040 processor when storing data to memory; somewhat less if also updating a graphical display. The memory requirements are roughly five bytes per image pixel. Both computational and memory costs may be reduced

  18. Collaborative Approaches and Policy Opportunities for Accelerated Progress toward Effective Disease Prevention, Care, and Control: Using the Case of Poverty Diseases to Explore Universal Access to Affordable Health Care

    Directory of Open Access Journals (Sweden)

    Samia Laokri

    2017-08-01

    Full Text Available BackgroundThere is a massive global momentum to progress toward the sustainable development and universal health coverage goals. However, effective policies to health-care coverage can only emerge through high-quality services delivered to empowered care users by means of strong local health systems and a translational standpoint. Health policies aimed at removing user fees for a defined health-care package may fail at reaching desired results if not applied with system thinking.MethodSecondary data analysis of two country-based cost-of-illness studies was performed to gain knowledge in informed decision-making toward enhanced access to care in the context of resource-constraint settings. A scoping review was performed to map relevant experiences and evidence underpinning the defined research area, the economic burden of illness.FindingsOriginal studies reflected on catastrophic costs to patients because of care services use and related policy gaps. Poverty diseases such as tuberculosis (TB may constitute prime examples to assess the extent of effective high-priority health-care coverage. Our findings suggest that a share of the economic burden of illness can be attributed to implementation failures of health programs and supply-side features, which may highly impair attainment of the global stated goals. We attempted to define and discuss a knowledge development framework for effective policy-making and foster system levers for integrated care.DiscussionBottlenecks to effective policy persist and rely on interrelated patterns of health-care coverage. Health system performance and policy responsiveness have to do with collaborative work among all health stakeholders. Public–private mix strategies may play a role in lowering the economic burden of disease and solving some policy gaps. We reviewed possible added value and pitfalls of collaborative approaches to enhance dynamic local knowledge development and realize integration with the various

  19. Collaborative Approaches and Policy Opportunities for Accelerated Progress toward Effective Disease Prevention, Care, and Control: Using the Case of Poverty Diseases to Explore Universal Access to Affordable Health Care.

    Science.gov (United States)

    Laokri, Samia

    2017-01-01

    There is a massive global momentum to progress toward the sustainable development and universal health coverage goals. However, effective policies to health-care coverage can only emerge through high-quality services delivered to empowered care users by means of strong local health systems and a translational standpoint. Health policies aimed at removing user fees for a defined health-care package may fail at reaching desired results if not applied with system thinking. Secondary data analysis of two country-based cost-of-illness studies was performed to gain knowledge in informed decision-making toward enhanced access to care in the context of resource-constraint settings. A scoping review was performed to map relevant experiences and evidence underpinning the defined research area, the economic burden of illness. Original studies reflected on catastrophic costs to patients because of care services use and related policy gaps. Poverty diseases such as tuberculosis (TB) may constitute prime examples to assess the extent of effective high-priority health-care coverage. Our findings suggest that a share of the economic burden of illness can be attributed to implementation failures of health programs and supply-side features, which may highly impair attainment of the global stated goals. We attempted to define and discuss a knowledge development framework for effective policy-making and foster system levers for integrated care. Bottlenecks to effective policy persist and rely on interrelated patterns of health-care coverage. Health system performance and policy responsiveness have to do with collaborative work among all health stakeholders. Public-private mix strategies may play a role in lowering the economic burden of disease and solving some policy gaps. We reviewed possible added value and pitfalls of collaborative approaches to enhance dynamic local knowledge development and realize integration with the various health-care silos. Despite a large political

  20. Infrastructures of progress and dispossession

    DEFF Research Database (Denmark)

    Andersen, Astrid Oberborbeck

    2016-01-01

    and organizational infrastructural arrangements, it is argued, can open up for understanding how local and beyond-local processes tangle in complex ways and are productive of new subjectivities; how relations are reconfi gured in neoliberal landscapes of progress and dispossession. Such an approach makes evident how...... to reposition small and medium-scale farmers as backward. Th is article analyzes how farmers struggle to fi nd their place within a neoliberal urban ecology where diff erent conceptions of what constitutes progress in contemporary Peru infl uence the landscape. Using an analytical lens that takes material...... and organizational infrastructures and practices into account, and situates these in specifi c historical processes, the article argues that farmers within the urban landscape of Arequipa struggle to reclaim land and water, and reassert a status that they experience to be losing. Such a historical focus on material...

  1. Progressive geometric algorithms

    NARCIS (Netherlands)

    Alewijnse, S.P.A.; Bagautdinov, T.M.; de Berg, M.T.; Bouts, Q.W.; ten Brink, Alex P.; Buchin, K.A.; Westenberg, M.A.

    2015-01-01

    Progressive algorithms are algorithms that, on the way to computing a complete solution to the problem at hand, output intermediate solutions that approximate the complete solution increasingly well. We present a framework for analyzing such algorithms, and develop efficient progressive algorithms

  2. Progressive geometric algorithms

    NARCIS (Netherlands)

    Alewijnse, S.P.A.; Bagautdinov, T.M.; Berg, de M.T.; Bouts, Q.W.; Brink, ten A.P.; Buchin, K.; Westenberg, M.A.

    2014-01-01

    Progressive algorithms are algorithms that, on the way to computing a complete solution to the problem at hand, output intermediate solutions that approximate the complete solution increasingly well. We present a framework for analyzing such algorithms, and develop efficient progressive algorithms

  3. White matter lesion progression

    DEFF Research Database (Denmark)

    Hofer, Edith; Cavalieri, Margherita; Bis, Joshua C

    2015-01-01

    10 cohorts. To assess the relative contribution of genetic factors to progression of WML, we compared in 7 cohorts risk models including demographics, vascular risk factors plus single-nucleotide polymorphisms that have been shown to be associated cross-sectionally with WML in the current......BACKGROUND AND PURPOSE: White matter lesion (WML) progression on magnetic resonance imaging is related to cognitive decline and stroke, but its determinants besides baseline WML burden are largely unknown. Here, we estimated heritability of WML progression, and sought common genetic variants...... associated with WML progression in elderly participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. METHODS: Heritability of WML progression was calculated in the Framingham Heart Study. The genome-wide association study included 7773 elderly participants from...

  4. The Thermochronologist's Progress

    Science.gov (United States)

    Zeitler, P. K.

    2011-12-01

    We owe our current understanding of thermochronology less to a series of revolutionary insights than to a somewhat uneven intellectual pilgrimage that over fifty years has progressed in fits and starts. Though hampered at times by overenthusiasm, oversimplification, and misunderstandings, on balance the field advanced thanks to a blend of curiosity-driven research, tool-building motivated by new ideas about Earth science, and improvements in technology. But now that we've exploited most radiogenic systems and the major minerals that host them, and now that our models can devour CPU time along with the best of them, are we done? Have we reached peak thermochron? The answer of course is no, and papers in this session will demonstrate what new technologies and techniques might have to offer in the coming years. However, I will argue that the discipline as a whole has matured to a point where if thermochronology is to remain a mainstream tool as opposed to a weekend sport, we need to get serious about several challenges. The most fundamental challenge is that current geodynamic models (and even more complex models we can envision coding) have outpaced our meagre stockpile of kinetic calibrations, our understanding of detailed isotope systematics, and our ability to generate data with sufficient throughput. These issues will not be addressed adequately through the business-as-usual approach that brought us to our current knowledge, and some community effort will probably be needed to coordinate the hard work that will be required. But any serious attempt to answer important questions with accurate thermal histories that have low and well-defined uncertainties will require that we actually know the kinetics for the specific samples we are analyzing, that we fully understand scatter in the data, that we work with the large sample numbers that are required for some problems like landscape evolution, and that inversion tools fully explore the important aspects of both the

  5. Discovering biological progression underlying microarray samples.

    Directory of Open Access Journals (Sweden)

    Peng Qiu

    2011-04-01

    Full Text Available In biological systems that undergo processes such as differentiation, a clear concept of progression exists. We present a novel computational approach, called Sample Progression Discovery (SPD, to discover patterns of biological progression underlying microarray gene expression data. SPD assumes that individual samples of a microarray dataset are related by an unknown biological process (i.e., differentiation, development, cell cycle, disease progression, and that each sample represents one unknown point along the progression of that process. SPD aims to organize the samples in a manner that reveals the underlying progression and to simultaneously identify subsets of genes that are responsible for that progression. We demonstrate the performance of SPD on a variety of microarray datasets that were generated by sampling a biological process at different points along its progression, without providing SPD any information of the underlying process. When applied to a cell cycle time series microarray dataset, SPD was not provided any prior knowledge of samples' time order or of which genes are cell-cycle regulated, yet SPD recovered the correct time order and identified many genes that have been associated with the cell cycle. When applied to B-cell differentiation data, SPD recovered the correct order of stages of normal B-cell differentiation and the linkage between preB-ALL tumor cells with their cell origin preB. When applied to mouse embryonic stem cell differentiation data, SPD uncovered a landscape of ESC differentiation into various lineages and genes that represent both generic and lineage specific processes. When applied to a prostate cancer microarray dataset, SPD identified gene modules that reflect a progression consistent with disease stages. SPD may be best viewed as a novel tool for synthesizing biological hypotheses because it provides a likely biological progression underlying a microarray dataset and, perhaps more importantly, the

  6. Progress test utopia.

    Science.gov (United States)

    van der Vleuten, Cees; Freeman, Adrian; Collares, Carlos Fernando

    2018-04-01

    This paper discusses the advantages of progress testing. A utopia is described where medical schools would work together to develop and administer progress testing. This would lead to a significant reduction of cost, an increase in the quality of measurement and phenomenal feedback to learner and school. Progress testing would also provide more freedom and resources for more creative in-school assessment. It would be an educationally attractive alternative for the creation of cognitive licensing exams. A utopia is always far away in the future, but by formulating a vision for that future we may engage in discussions on how to get there.

  7. Waste management progress report

    International Nuclear Information System (INIS)

    1997-06-01

    During the Cold War era, when DOE and its predecessor agencies produced nuclear weapons and components, and conducted nuclear research, a variety of wastes were generated (both radioactive and hazardous). DOE now has the task of managing these wastes so that they are not a threat to human health and the environment. This document is the Waste Management Progress Report for the U.S. Department of Energy dated June 1997. This progress report contains a radioactive and hazardous waste inventory and waste management program mission, a section describing progress toward mission completion, mid-year 1997 accomplishments, and the future outlook for waste management

  8. Progressive Finland sees progress with nuclear projects

    Energy Technology Data Exchange (ETDEWEB)

    Dalton, David [NucNet, Brussels (Belgium)

    2016-02-15

    The Finnish Hanhikivi-1 reactor project is firmly on track and a licence has been granted for construction of a final disposal facility for spent nuclear fuel - the first final repository in the world to enter the construction phase. Significant progress has been made with plans for Finland to build its sixth nuclear reactor unit at Hanhikivi. Fennovoima's licensing manager Janne Liuko said the company expects to receive the construction licence for the Generation III+ Hanhikivi-1 plant in late 2017. The application was submitted to the Finnish Ministry of Employment and the Economy in June 2015.

  9. Progression of Liver Disease

    Science.gov (United States)

    ... Legacy Society Make Gifts of Stock Donate Your Car Personal Fundraising Partnership & Support Share Your Story Spread the Word Give While You Shop Contact Us Donate Now The Progression of Liver ...

  10. Progression of Liver Disease

    Science.gov (United States)

    ... Liver Function Tests Clinical Trials Liver Transplant FAQs Medical Terminology Diseases of the Liver Alagille Syndrome Alcohol-Related ... the Liver The Progression of Liver Disease FAQs Medical Terminology HOW YOU CAN HELP Sponsorship Ways to Give ...

  11. Progress report for '89

    International Nuclear Information System (INIS)

    Podest, M.

    1990-08-01

    The 1989 Progress Report presents the most important scientific and technical achievements of the Nuclear Research Institute's research work. Some specialized products prepared at or fabricated by the NRI are mentioned as well. (author). 24 figs., 8 tabs., 101 refs

  12. Progress report, Physics Division

    International Nuclear Information System (INIS)

    1986-03-01

    This report reviews events and progress in the following areas: development of the TASCC facility; experimental and theoretical nuclear physics research; radionuclide standardization; condensed matter research; applied mathematics; and computer facility operation

  13. Progress for the Paralyzed

    Science.gov (United States)

    ... Contents Latest Advances Help People Regain Function and Independence Founded in 2000, the National Institute for Biomedical ... More "NIBIB Robotics" Articles Progress for the Paralyzed / College Athlete Stands Again…On His Own! / Coffee to ...

  14. Progress report 1979

    International Nuclear Information System (INIS)

    1979-01-01

    Progress report on the meetings and working groups of DAF in 1979, e.g. engineering and industry, public and press, law and administration, business and industry, international cooperation in Europe and with the USA. (GL) [de

  15. Progress report 1985

    International Nuclear Information System (INIS)

    1986-01-01

    This progress report of the nuclear physics institute includes five basic subjects: theoretical physics, high energy and intermediate energy physics, nuclear physics, combined research physics and instrumentation (microelectronics, imaging, multidetectors, scintillators,...) [fr

  16. Modeling Progress in AI

    OpenAIRE

    Brundage, Miles

    2015-01-01

    Participants in recent discussions of AI-related issues ranging from intelligence explosion to technological unemployment have made diverse claims about the nature, pace, and drivers of progress in AI. However, these theories are rarely specified in enough detail to enable systematic evaluation of their assumptions or to extrapolate progress quantitatively, as is often done with some success in other technological domains. After reviewing relevant literatures and justifying the need for more ...

  17. [Progressive visual agnosia].

    Science.gov (United States)

    Sugimoto, Azusa; Futamura, Akinori; Kawamura, Mitsuru

    2011-10-01

    Progressive visual agnosia was discovered in the 20th century following the discovery of classical non-progressive visual agnosia. In contrast to the classical type, which is caused by cerebral vascular disease or traumatic injury, progressive visual agnosia is a symptom of neurological degeneration. The condition of progressive visual loss, including visual agnosia, and posterior cerebral atrophy was named posterior cortical atrophy (PCA) by Benson et al. (1988). Progressive visual agnosia is also observed in semantic dementia (SD) and other degenerative diseases, but there is a difference in the subtype of visual agnosia associated with these diseases. Lissauer (1890) classified visual agnosia into apperceptive and associative types, and it in most cases, PCA is associated with the apperceptive type. However, SD patients exhibit symptoms of associative visual agnosia before changing to those of semantic memory disorder. Insights into progressive visual agnosia have helped us understand the visual system and discover how we "perceive" the outer world neuronally, with regard to consciousness. Although PCA is a type of atypical dementia, its diagnosis is important to enable patients to live better lives with appropriate functional support.

  18. National-level progress on adaptation

    NARCIS (Netherlands)

    Lesnikowski, A.; Ford-Robertson, J.; Biesbroek, G.R.; Berrang-Ford, L.; Heymann, S.J.

    2016-01-01

    It is increasingly evident that adaptation will figure prominently in the post-2015 United Nations climate change agreement. As adaptation obligations under the United Nations Framework Convention on Climate Change evolve, more rigorous approaches to measuring adaptation progress among parties will

  19. Physicians’ Progress Notes

    DEFF Research Database (Denmark)

    Bansler, Jørgen; Havn, Erling C.; Mønsted, Troels

    2013-01-01

    in patient care, they have not dealt specifically with the role, structure, and content of the progress notes. As a consequence, CSCW research has not yet taken fully into account the fact that progress notes are coordinative artifacts of a rather special kind, an open-ended chain of prose texts, written...... sequentially by cooperating physicians for their own use as well as for that of their colleagues. We argue that progress notes are the core of the medical record, in that they marshal and summarize the overwhelming amount of data that is available in the modern hospital environment, and that their narrative...... format is uniquely adequate for the pivotal epistemic aspect of cooperative clinical work: the narrative format enables physicians to not only record ‘facts’ but also—by filtering, interpreting, organizing, and qualifying information—to make sense and act concertedly under conditions of uncertainty...

  20. Chronic progressive multiple sclerosis

    International Nuclear Information System (INIS)

    Buffoli, A.; Micheletti, E.; Capra, R.; Mattioli, F.; Marciano', N.

    1991-01-01

    A long-lasting immunological suppression action seems to be produced by total lymphoid irradiation; some authors emphasize the favorable effect of this treatment on chronic progressive multiple sclerosis. In order to evaluate the actual role of TLI, 6 patients affected with chronic progressive multiple sclerosis were submitted to TLI with shaped and personalized fields at the Istituto del Radio, University of Brescia, Italy. The total dose delivered was 19.8 Gy in 4 weeks, 1.8 Gy/day, 5d/w; a week elapsed between the first and the second irradiation course. Disability according to Kurtzke scale was evaluated, together with blood lymphocyte count and irradiation side-effects, over a mean follow-up period of 20.8 months (range: 13-24). Our findings indicate that: a) disease progression was not markedly reduced by TLI; b) steroid hormones responsivity was restored after irradiation, and c) side-effects were mild and tolerable

  1. Progress in physical chemistry

    CERN Document Server

    Hempelmann, Rolf

    2008-01-01

    Progress in Physical Chemistry is a collection of recent ""Review Articles"" published in the ""Zeitschrift für Physikalische Chemie"". The second volume of Progress in Physical Chemistry is a collection of thematically closely related minireview articles written by the members of the Collaborative Research Centre (SFB) 277 of the German Research Foundation (DFG). These articles are based on twelve years of intense coordinated research efforts. Central topics are the synthesis and the characterization of interface-dominated, i.e. nanostructured materials, mainly in the solid state but also as

  2. Progress report 1981

    International Nuclear Information System (INIS)

    Chalupka, A.; Dirninger, G.

    1982-01-01

    The progress report describes the scientific work and research results of the institute for radium research and nuclear physics of the Austrian Academy of Sciences for the period of 1981. The progress report covers the subject areas of nuclear theory, nuclear model calculations, experimental nuclear physics and neutron involved reactions, medium energy physics, instrumentation and detectors, evaluation of nuclear data and numerical data processing, dating, applications in medicine, dosimetry and environmental studies. A list of publications of this institute is given. (A.N.)

  3. Annual progress report 1981

    International Nuclear Information System (INIS)

    1982-01-01

    This annual progress report of the CEA Protection and Nuclear Safety Institut outlines a brief description of the progress made in each section of the Institut. Research activities of the Protection department include, radiation effects on man, radioecology and environment radioprotection techniques. Research activities of the Nuclear Safety department include, reactor safety analysis, fuel cycle facilities safety analysis, safety research programs. The third section deals with nuclear material security including security of facilities, security of nuclear material transport and monitoring of nuclear material management [fr

  4. Progress report 1982

    International Nuclear Information System (INIS)

    Chalupka, A.; Wild, E.; Dirninger, G.

    1983-01-01

    The progress report describes the scientific work and research results of the institute for radium research and nuclear physics of the Austrian Academy of Sciences for the period of 1982. The progress report covers the subject areas of nuclear theory, nuclear model calculations, experimental nuclear physics and neutron involved reactions, medium energy physics, instrumentation and detectors, evaluation of nuclear data and numerical data processing, dating, applications in medicine, dosimetry and environmental studies. A list of publications of this institute is given. (A.N.)

  5. 1985. Annual progress report

    International Nuclear Information System (INIS)

    1986-01-01

    This annual progress report of the CEA Protection and Nuclear Safety Institut outlines a description of the progress made in each sections of the Institut Research activities of the different departments include: reactor safety analysis, fuel cycle facilities analysis; and associated safety research programs (criticality, sites, transport ...), radioecology and environmental radioprotection techniques; data acquisition on radioactive waste storage sites; radiation effects on man, studies on radioprotection techniques; nuclear material security including security of facilities, security of nuclear material transport, and monitoring of nuclear material management; nuclear facility decommissioning; and finally the public information [fr

  6. BARC progress report - 1998

    Energy Technology Data Exchange (ETDEWEB)

    Kalyane, V L [comp.; Library and Information Services Div., Bhabha Atomic Research Centre, Mumbai (India)

    1999-04-01

    This report is a compilation of the progress in various major activities and Research and Development programmes of the different Divisions of the Bhabha Atomic Research Centre, Mumbai. The list of publications and papers presented at the various conferences, symposia, workshops and papers published in journal by the staff members of the Divisions are also given. (author) figs., tabs.

  7. BARC progress report - 1998

    International Nuclear Information System (INIS)

    Kalyane, V.L.

    1999-04-01

    This report is a compilation of the progress in various major activities and Research and Development programmes of the different Divisions of the Bhabha Atomic Research Centre, Mumbai. The list of publications and papers presented at the various conferences, symposia, workshops and papers published in journal by the staff members of the Divisions are also given. (author)

  8. Internationalisering og progression

    DEFF Research Database (Denmark)

    Wilken, Lisanne; Tange, Hanne

    2014-01-01

    means that programs can attract students from outside Denmark, and these students often come from different academic backgrounds. To investigate how these changes are affecting the way professors who teach on interdisciplinary international masters programs conceive student progress, we carried out semi...

  9. Progress report of CJD

    International Nuclear Information System (INIS)

    2002-01-01

    This paper is the progress report of the Russian Nuclear Data Center at F.E.I., Obninsk. Evaluations have been made for dosimetry reactions and neutron reactions. Analysis of the spectra and the production cross sections were made. (a.n.)

  10. Progress report 1982

    International Nuclear Information System (INIS)

    Paul, H.

    1983-01-01

    This progress report describes the scientific work and research results done by the institute for experimental physics, atom and nuclear physics of the Johannes-Kepler-Universitaet Linz in the period of 1982. The covered subject areas are ionization by cations, investigations of surface areas by light ions, measurement of stopping power in solids, data acquisition and aerosol physics. (A.N.)

  11. Recent progress in Biophysics

    International Nuclear Information System (INIS)

    Bemski, G.

    1980-03-01

    Recent progress in biophysics is reviewed, and three examples of the use of physical techniques and ideas in biological research are given. The first one deals with the oxygen transporting protein-hemoglobin, the second one with photosynthesis, and the third one with image formation, using nuclear magnetic resonance. (Author) [pt

  12. MCNP Progress & Performance Improvements

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Forrest B. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Bull, Jeffrey S. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Rising, Michael Evan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-04-14

    Twenty-eight slides give information about the work of the US DOE/NNSA Nuclear Criticality Safety Program on MCNP6 under the following headings: MCNP6.1.1 Release, with ENDF/B-VII.1; Verification/Validation; User Support & Training; Performance Improvements; and Work in Progress. Whisper methodology will be incorporated into the code, and run speed should be increased.

  13. Scales of Progress

    Science.gov (United States)

    Jung, Lee Ann

    2018-01-01

    What is Goal Attainment Scaling? In this article, Lee Ann Jung defines it as a way to measure a student's progress toward an individualized goal. Instead of measuring a skill at a set time (for instance, on a test or other assignment), Goal Attainment Scaling tracks the steps a student takes over the course of a year in a targeted skill. Together,…

  14. Progressive Retirement Programme

    CERN Document Server

    HR Department

    2009-01-01

    Following the Standing Concertation Committee meeting of 2 December 2008, please note that the Progressive Retirement Programme has been extended by one year, i.e. until 31 March 2010. Further information is available on : https://hr-services.web.cern.ch/hr-services/services-Ben/prp/prp.asp HR Department, tel. 73903

  15. Progress Report 1994

    International Nuclear Information System (INIS)

    1995-01-01

    This document is the 1994 annual progress report of the CEA-Direction of Waste Management (DGD). It comprises four chapters. The first chapter is a general presentation of radioactive wastes, of the management of liquid effluents, solid wastes, sealed sources, of the relations with the ANDRA (The French Agency for the Management of Radioactive Wastes), and of the research and development studies in progress for the improvement of waste management. The second chapter concerns the spent fuels and their reprocessing, in particular AGR and PWR type reactor fuels, the ''Caramel'' fuel from Osiris reactor and the cover elements from the Rapsodie reactor core. The long time storage of ancient fuels is also discussed. The third chapter concerns the dismantling of decommissioned installations, the actions in progress and the planning of dismantling actions up to the year 2000. Chapter four is devoted to the management of wastes from the Direction of Military Applications (DAM), the actions in progress in the different DAM centers and the cleansing projects at Marcoule plant. (J.S.). 5 figs., 28 tabs., 21 photos., 3 appendix

  16. Progress report 1979

    International Nuclear Information System (INIS)

    1980-12-01

    This progress report deals with technical and research work done at the AAEC Research Establishment in the twelve month period ending September 30, 1979. Work done in the following research divisions is reported: Applied Maths and Computing, Chemical Technology, Engineering Research, Environmental Science, Instrumentation and Control, Isotope, Materials and Physics

  17. Progress in optics

    CERN Document Server

    Wolf, Emil

    2015-01-01

    The Progress in Optics series contains more than 300 review articles by distinguished research workers, which have become permanent records for many important developments, helping optical scientists and optical engineers stay abreast of their fields. Comprehensive, in-depth reviewsEdited by the leading authority in the field

  18. Progress in inertial fusion

    International Nuclear Information System (INIS)

    Hogan, W.; Storm, E.

    1985-10-01

    The requirements for high gain in inertial confinement are given in terms of target implosion requirements. Results of experimental studies of the laser/target interaction and of the dynamics of laser implosion. A report of the progress of advanced laser development is also presented. 3 refs., 8 figs., 1 tab

  19. Progress report 1978

    International Nuclear Information System (INIS)

    1979-01-01

    The Studsvik Science Research Laboratory herewith presents its progress report for 1978. The report summarizes the current projects carried out by the research groups working at the laboratory. Projects within the following fields are presented: neutron physics, neutron absorption and scattering, radiation chemistry, radiation damage studies, radioactivity and theoretical studies of condensed matter. (E.R.)

  20. Progress report 1981

    International Nuclear Information System (INIS)

    After giving a brief description of operations of an improvements to the University of Alberta nuclear physics facilities, this report summarizes the principal research programs. These include work on neutron scattering, thorium 232 fission, iodine 123 production. Progress towards the construction of MARIA, the Medical Accelerator Research Institute in Alberta, is described, and research on relativistic heavy ions is summarized

  1. BARC progress report - 1997

    Energy Technology Data Exchange (ETDEWEB)

    Kalyane, V L [comp.; Library and Information Services Div., Bhabha Atomic Research Centre, Mumbai (India)

    1998-07-01

    This report is a compilation of the progress in various major activities and Research and Development programmes of the different Divisions of the Bhabha Atomic Research Centre, Mumbai. The list of publications and papers presented at the various conferences, symposia, workshops and papers published in journal by the staff members of the Divisions are also given. (author) figs., tabs.

  2. BARC progress report - 1997

    International Nuclear Information System (INIS)

    Kalyane, V.L.

    1998-07-01

    This report is a compilation of the progress in various major activities and Research and Development programmes of the different Divisions of the Bhabha Atomic Research Centre, Mumbai. The list of publications and papers presented at the various conferences, symposia, workshops and papers published in journal by the staff members of the Divisions are also given. (author)

  3. Response: Progress Takes Time.

    Science.gov (United States)

    Rist, Marilee C.

    1984-01-01

    Although declining enrollment and administrative seniority have hampered efforts to eliminate sex discrimination in employment practices in three Long Island, New York, school systems (Commack, Smithtown, and Bay Shore), progress is being made. Because of the Reagan administration's lack of support for affirmative action, however, litigation…

  4. Progressive Web applications

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    Progressive Web Applications are native-like applications running inside of a browser context. In my presentation I would like describe their characteristics, benchmarks and building process using a quick and simple case study example with focus on Service Workers api.

  5. "Paideia," Progress, Puzzlement

    Science.gov (United States)

    Hrachovec, Herbert

    2018-01-01

    Platonic "paideia" is a mainstream concept in traditional philosophy and humanistic circles generally. It is closely connected with social progress brought about by the dynamics of enlightenment and self-fulfillment, symbolized by the allegory of the cave. The main contention of this paper is that the philosophical grammar of this simile…

  6. Are Forecast Updates Progressive?

    NARCIS (Netherlands)

    C-L. Chang (Chia-Lin); Ph.H.B.F. Franses (Philip Hans); M.J. McAleer (Michael)

    2010-01-01

    textabstractMacro-economic forecasts typically involve both a model component, which is replicable, as well as intuition, which is non-replicable. Intuition is expert knowledge possessed by a forecaster. If forecast updates are progressive, forecast updates should become more accurate, on average,

  7. Progress report 1979

    International Nuclear Information System (INIS)

    1980-12-01

    This progress report deals with service oriented work performed at the AAEC Research Establishment in the twelve month period ending September 30, 1979. Services provided by the Engineering Services Division, the Safety Department, Site Information Services Department and Commercial Applications are described

  8. Progression og underviserkompetencer

    Directory of Open Access Journals (Sweden)

    Lene Tortzen Bager

    2014-03-01

    Full Text Available På baggrund af en kvalitativ interviewundersøgelse af undervisere ved Aarhus Universitet lavet i 2012, tematiserer artiklen, hvordan undervisere udvikler deres faglige og pædagogiske kompetencer i forhold til at kunne skabe progression inden for innovation og entreprenørskab forstået enten som didaktik, arbejdsformer i faglige forløb eller som fag på universitetet. I arbejdet med progression er det en udfordring at integrere de nye faglige dimensioner i det kernefaglige felt. Den seneste model for progression inden for innovation og entreprenør-skab siger, at det er den lærendes generelle erfaringsniveau, der er den afgørende progressionsskabende faktor (Progressionsmodellen, Fonden for Entreprenørskab, 2013b. Samtidig skelner international forskning inden for studiekompetenceområdet mellem niveauer, hvor indlejret viden er det mest avancerede kompetenceniveau (Barrie, 2002.Ifølge progressionsmodellen og den nævnte kompetenceforskning er erfaring og dybt integreret læring altså centrale dimensioner i progression. Men hvad er underviserens rolle heri? Underviserens professionelle udviklingsarbejde forekommer at være underbelyst i forhold til, at underviseren er den legitime garant for integrationen af nye faglige dimensioner og for den studerendes kompetenceniveau. Interviewundersøgelsen forholder sig til spørgsmålet om progression gennem de deltagende underviseres beskrivelse af betydningslag i entreprenørskabsbegrebet koblet til de praksisformer i undervisningen, der knytter sig hertil samt et indblik i undervisernes refleksioner over deres kompetenceudviklingsprocesser. Artiklens bidrag til progression er at se underviserens motivation og kompetenceudvikling som forudsætninger herfor.     Based on a qualitative study of five teachers in the Faculty of Arts at Aarhus University that took place during 2012, the article thematizes how teachers develop their professional and educational qualifications in innovation and

  9. Evaluation of keratoconus progression.

    Science.gov (United States)

    Shajari, Mehdi; Steinwender, Gernot; Herrmann, Kim; Kubiak, Kate Barbara; Pavlovic, Ivana; Plawetzki, Elena; Schmack, Ingo; Kohnen, Thomas

    2018-06-01

    To define variables for the evaluation of keratoconus progression and to determine cut-off values. In this retrospective cohort study (2010-2016), 265 eyes of 165 patients diagnosed with keratoconus underwent two Scheimpflug measurements (Pentacam) that took place 1 year apart ±3 months. Variables used for keratoconus detection were evaluated for progression and a correlation analysis was performed. By logistic regression analysis, a keratoconus progression index (KPI) was defined. Receiver-operating characteristic curve (ROC) analysis was performed and Youden Index calculated to determine cut-off values. Variables used for keratoconus detection showed a weak correlation with each other (eg, correlation r=0.245 between RPImin and Kmax, pKPI). KPI was defined by logistic regression and consisted of a Pachymin coefficient of -0.78 (p=0.001), a maximum elevation of back surface coefficient of 0.27 and coefficient of corneal curvature at the zone 3 mm away from the thinnest point on the posterior corneal surface of -12.44 (both pKPI: D-index had a cut-off of 0.4175 (70.6% sensitivity) and Youden Index of 0.606. Cut-off for KPI was -0.78196 (84.7% sensitivity) and a Youden Index of 0.747; both 90% specificity. Keratoconus progression should be defined by evaluating parameters that consider several corneal changes; we suggest D-index and KPI to detect progression. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  10. Progress on HELIAS systems studies

    Energy Technology Data Exchange (ETDEWEB)

    Warmer, Felix; Beidler, Craig D.; Dinklage, Andreas; Feng, Yuehe; Geiger, Joachim; Schauer, Felix; Turkin, Yuriy; Wolf, Robert; Xanthopoulos, Pavlos [Max-Planck-Institut fuer Plasmaphysik, D-17491 Greifswald (Germany); Kemp, Richard; Knight, Peter; Ward, David [Culham Centre for Fusion Energy, Abingdon, Oxfordshire, OX14 3DB (United Kingdom)

    2015-05-01

    In order to study and design next-step fusion devices such as DEMO, comprehensive systems codes are commonly employed. For the HELIAS-line, stellarator-specific models have been developed, implemented, and verified within the systems code PROCESS. This systems code ansatz is complemented by self-consistent modeling of plasma scenarios employing a predictive 1-D neoclassical transport code which has been augmented with a model for the edge anomalous transport based on 3-D ITG turbulence simulations. This approach is investigated to ultimately allow one to conduct stellarator system studies, develop design points of HELIAS burning plasma devices, and to facilitate a direct comparison between tokamak and stellarator DEMO and power plant designs. The work reports on the progress towards these goals.

  11. World progress toward fusion energy

    International Nuclear Information System (INIS)

    Clarke, J.F.

    1989-09-01

    This paper will describe the progress in fusion science and technology from a world perspective. The paper will cover the current technical status, including the understanding of fusion's economic, environmental, and safety characteristics. Fusion experiments are approaching the energy breakeven condition. An energy gain (Q) of 30 percent has been achieved in magnetic confinement experiments. In addition, temperatures required for an ignited plasma (Ti = 32 KeV) and energy confinements about 75 percent of that required for ignition have been achieved in separate experiments. Two major facilities have started the experimental campaign to extend these results and achieve or exceed Q = 1 plasma conditions by 1990. Inertial confinement fusion experiments are also approaching thermonuclear conditions and have achieved a compression factor 100-200 times liquid D-T. Because of this progress, the emphasis in fusion research is turning toward questions of engineering feasibility. Leaders of the major fusion R and D programs in the European Community (EC), Japan, the United States, and the U.S.S.R. have agreed on the major steps that are needed to reach the point at which a practical fusion system can be designed. The United States is preparing for an experiment to address the last unexplored scientific issue, the physics of an ignited plasma, during the late 1990's. The EC, Japan, U.S.S.R., and the United States have joined together under the auspices of the International Atomic Energy Agency (IAEA) to jointly design and prepare the validating R and D for an international facility, the International Thermonuclear Experimental Reactor (ITER), to address all the remaining scientific issues and to explore the engineering technology of fusion around the turn of the century. In addition, a network of international agreements have been concluded between these major parties and a number of smaller fusion programs, to cooperate on resolving a complete spectrum of fusion science and

  12. Kant’s Theory of Progress

    OpenAIRE

    McCloughan, Meade

    2008-01-01

    My topic is Kant’s theory of historical progress. My approach is primarily textual and contextual. I analyse in some detail Kant’s three most important essays on the topic: ‘Idea for a Universal History’, the third part of ‘Theory and Practice’ and the second part of The Conflict of the Faculties. I devote particular attention to the Kant-Herder debate about progress, but also discuss Rousseau, Mendelssohn, Hegel and others. In presenting, on Kant’s behalf, a strong case for his theory of pro...

  13. Progressive posterior cortical dysfunction

    Directory of Open Access Journals (Sweden)

    Fábio Henrique de Gobbi Porto

    Full Text Available Abstract Progressive posterior cortical dysfunction (PPCD is an insidious syndrome characterized by prominent disorders of higher visual processing. It affects both dorsal (occipito-parietal and ventral (occipito-temporal pathways, disturbing visuospatial processing and visual recognition, respectively. We report a case of a 67-year-old woman presenting with progressive impairment of visual functions. Neurologic examination showed agraphia, alexia, hemispatial neglect (left side visual extinction, complete Balint's syndrome and visual agnosia. Magnetic resonance imaging showed circumscribed atrophy involving the bilateral parieto-occipital regions, slightly more predominant to the right . Our aim was to describe a case of this syndrome, to present a video showing the main abnormalities, and to discuss this unusual presentation of dementia. We believe this article can contribute by improving the recognition of PPCD.

  14. Progressive posterior cortical dysfunction

    Science.gov (United States)

    Porto, Fábio Henrique de Gobbi; Machado, Gislaine Cristina Lopes; Morillo, Lilian Schafirovits; Brucki, Sonia Maria Dozzi

    2010-01-01

    Progressive posterior cortical dysfunction (PPCD) is an insidious syndrome characterized by prominent disorders of higher visual processing. It affects both dorsal (occipito-parietal) and ventral (occipito-temporal) pathways, disturbing visuospatial processing and visual recognition, respectively. We report a case of a 67-year-old woman presenting with progressive impairment of visual functions. Neurologic examination showed agraphia, alexia, hemispatial neglect (left side visual extinction), complete Balint’s syndrome and visual agnosia. Magnetic resonance imaging showed circumscribed atrophy involving the bilateral parieto-occipital regions, slightly more predominant to the right. Our aim was to describe a case of this syndrome, to present a video showing the main abnormalities, and to discuss this unusual presentation of dementia. We believe this article can contribute by improving the recognition of PPCD. PMID:29213665

  15. Decision-Making Accuracy of CBM Progress-Monitoring Data

    Science.gov (United States)

    Hintze, John M.; Wells, Craig S.; Marcotte, Amanda M.; Solomon, Benjamin G.

    2018-01-01

    This study examined the diagnostic accuracy associated with decision making as is typically conducted with curriculum-based measurement (CBM) approaches to progress monitoring. Using previously published estimates of the standard errors of estimate associated with CBM, 20,000 progress-monitoring data sets were simulated to model student reading…

  16. ISABELLE: a progress report

    Energy Technology Data Exchange (ETDEWEB)

    Hahn, H

    1980-01-01

    This paper discusses the ISABELLE project, which has the objective of constructing a high-energy proton colliding beam facility at Brookhaven National Laboratory. The major technical features of the intersecting storage accelerators with their projected performance are described. Application of over 1000 superconducting magnets in the two rings represents the salient characteristic of the machine. The status of the entire project, the technical progress made so far, and difficulties encountered are reviewed.

  17. ISABELLE: a progress report

    International Nuclear Information System (INIS)

    Hahn, H.

    1980-01-01

    This paper discusses the ISABELLE project, which has the objective of constructing a high-energy proton colliding beam facility at Brookhaven National Laboratory. The major technical features of the intersecting storage accelerators with their projected performance are described. Application of over 1000 superconducting magnets in the two rings represents the salient characteristic of the machine. The status of the entire project, the technical progress made so far, and difficulties encountered are reviewed

  18. Progress in optics

    CERN Document Server

    Wolf, Emil

    2009-01-01

    In the fourty-seven years that have gone by since the first volume of Progress in Optics was published, optics has become one of the most dynamic fields of science. The volumes in this series which have appeared up to now contain more than 300 review articles by distinguished research workers, which have become permanent records for many important developments.- Backscattering and Anderson localization of light- Advances in oliton manipulation in optical lattices- Fundamental quantum noise in optical amplification- Invisibility cloaks

  19. Progress in optics

    CERN Document Server

    Wolf, Emil

    2008-01-01

    In the fourty-six years that have gone by since the first volume of Progress in Optics was published, optics has become one of the most dynamic fields of science. The volumes in this series which have appeared up to now contain more than 300 review articles by distinguished research workers, which have become permanent records for many important developments.- Metamaterials- Polarization Techniques- Linear Baisotropic Mediums- Ultrafast Optical Pulses- Quantum Imaging- Point-Spread Funcions- Discrete Wigner Functions

  20. Clean Energy Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    For the past several years, the IEA and others have been calling for a clean energy revolution to achieve global energy security, economic growth and climate change goals. This report analyses for the first time progress in global clean energy technology deployment against the pathways that are needed to achieve these goals. It provides an overview of technology deployment status, key policy developments and public spending on RDD&D of clean energy technologies.

  1. Progress in nanophotonics 1

    CERN Document Server

    Ohtsu, Motoichi

    2011-01-01

    This book focuses on the recent progress in nanophotonics technology to be used to develop novel nano-optical devices, fabrication technology, and security systems. It begins with a review of the concept of dressed photons and applications to devices, fabrication, and systems; principles and applications. Further topics include: DNA process for quantum dot chain, photon enhanced emission microscopy, near field spectroscopy of metallic nanostructure, self-organized fabrication of composite semiconductor quantum dots, formation of metallic nanostructure, and nanophotonic information systems with

  2. Three year progress report

    International Nuclear Information System (INIS)

    1977-07-01

    Progress is reported on the following studies: x-ray and uv effects in photosynthetic organisms; effects of alcohols and oxygen concentration on transforming DNA; free radical studies; sensitization by metal ions; role of the solvated electron in radiation damage to cells; effectiveness of organic and inorganic compounds in sensitizing bacterial spores to high energy radiation; oxygen effects; radiosensitivity of enzyme systems in Chlorella; and effects of pre-irradiation of solutions on spores

  3. Progressive pseudorheumatoid dysplasia

    International Nuclear Information System (INIS)

    Mampaey, S.; De Schepper, A.; Vanhoenacker, F.; Boven, K.; Hul, W. van

    2000-01-01

    A rare case of progressive pseudorheumatoid dysplasia (PPD) in a 9-year-old girl is presented. Clinically, chronic painless swollen joints, accompanied by progressive motion restriction and progressive walking difficulties, were found. Radiologically, there was enlargement of the epimetaphyseal portions of the large joints, metacarpal heads, and phalanges, and generalized platyspondyly with irregular delineation of the endplates of the vertebral bodies. The radioclinical features at the peripheral joints were originally misdiagnosed as juvenile rheumatoid arthritis (JRA), and the structural spinal abnormalities were neglected and interpreted as Scheuermann's disease. However, the absence of active inflammatory parameters argues against JRA, whereas the low age of onset of the irregularities at the vertebral endplates is an argument against the diagnosis of Scheuermann's disease. The combination of the dysplastic abnormalities of the spine, with platyspondyly and Scheuermann-like lesions at an unusually low age of onset, and radiological features mimicking JRA of the peripheral joints, is the clue to the diagnosis of this rare autosomal-recessive disease. This case is the first to document the MRI features of PPD of the spine. (orig.)

  4. Work in progress Work in progress

    Directory of Open Access Journals (Sweden)

    Anita Runge

    2000-07-01

    Full Text Available Der Band versammelt thematisch und methodisch heterogene Beiträge aus der Geschichts-, Sprach- und Literaturwissenschaft. Gemeinsamer Bezugspunkt ist ein diskursanalytisch aufgefaßter gender-Begriff. Den aktuellen Stand der Diskussion reflektieren zwei Beiträge, die die Campus-(Kriminal-Romane von Amanda Cross und Antonia S. Byatt als ‚Meta-Texte‘ feministischer Theoriebildung interpretieren.This collection contains thematically and methodically heterogeneous articles from history, linguistics, and literary studies. Their common point of reference is a discours analytical approach to gender studies. The current discussion is reflected by two articles, that interpret the campus novels/thrillers by Amanda Cross and Antonia S. Byatt as being ‘meta texts’ of feminist theory construction.

  5. Content layer progressive coding of digital maps

    DEFF Research Database (Denmark)

    Forchhammer, Søren; Jensen, Ole Riis

    2000-01-01

    A new lossless context based method is presented for content progressive coding of limited bits/pixel images, such as maps, company logos, etc., common on the WWW. Progressive encoding is achieved by separating the image into content layers based on other predefined information. Information from...... already coded layers are used when coding subsequent layers. This approach is combined with efficient template based context bi-level coding, context collapsing methods for multi-level images and arithmetic coding. Relative pixel patterns are used to collapse contexts. The number of contexts are analyzed....... The new methods outperform existing coding schemes coding digital maps and in addition provide progressive coding. Compared to the state-of-the-art PWC coder, the compressed size is reduced to 60-70% on our layered test images....

  6. Content Layer progressive Coding of Digital Maps

    DEFF Research Database (Denmark)

    Forchhammer, Søren; Jensen, Ole Riis

    2002-01-01

    A new lossless context based method is presented for content progressive coding of limited bits/pixel images, such as maps, company logos, etc., common on the World Wide Web. Progressive encoding is achieved by encoding the image in content layers based on color level or other predefined...... information. Information from already coded layers are used when coding subsequent layers. This approach is combined with efficient template based context bilevel coding, context collapsing methods for multilevel images and arithmetic coding. Relative pixel patterns are used to collapse contexts. Expressions...... for calculating the resulting number of contexts are given. The new methods outperform existing schemes coding digital maps and in addition provide progressive coding. Compared to the state-of-the-art PWC coder, the compressed size is reduced to 50-70% on our layered map test images....

  7. Setting a research agenda for progressive multiple sclerosis: the International Collaborative on Progressive MS.

    Science.gov (United States)

    Fox, Robert J; Thompson, Alan; Baker, David; Baneke, Peer; Brown, Doug; Browne, Paul; Chandraratna, Dhia; Ciccarelli, Olga; Coetzee, Timothy; Comi, Giancarlo; Feinstein, Anthony; Kapoor, Raj; Lee, Karen; Salvetti, Marco; Sharrock, Kersten; Toosy, Ahmed; Zaratin, Paola; Zuidwijk, Kim

    2012-11-01

    Despite significant progress in the development of therapies for relapsing MS, progressive MS remains comparatively disappointing. Our objective, in this paper, is to review the current challenges in developing therapies for progressive MS and identify key priority areas for research. A collaborative was convened by volunteer and staff leaders from several MS societies with the mission to expedite the development of effective disease-modifying and symptom management therapies for progressive forms of multiple sclerosis. Through a series of scientific and strategic planning meetings, the collaborative identified and developed new perspectives on five key priority areas for research: experimental models, identification and validation of targets and repurposing opportunities, proof-of-concept clinical trial strategies, clinical outcome measures, and symptom management and rehabilitation. Our conclusions, tackling the impediments in developing therapies for progressive MS will require an integrated, multi-disciplinary approach to enable effective translation of research into therapies for progressive MS. Engagement of the MS research community through an international effort is needed to address and fund these research priorities with the ultimate goal of expediting the development of disease-modifying and symptom-relief treatments for progressive MS.

  8. Setting a research agenda for progressive multiple sclerosis: The International Collaborative on Progressive MS

    Science.gov (United States)

    Thompson, Alan; Baker, David; Baneke, Peer; Brown, Doug; Browne, Paul; Chandraratna, Dhia; Ciccarelli, Olga; Coetzee, Timothy; Comi, Giancarlo; Feinstein, Anthony; Kapoor, Raj; Lee, Karen; Salvetti, Marco; Sharrock, Kersten; Toosy, Ahmed; Zaratin, Paola; Zuidwijk, Kim

    2012-01-01

    Despite significant progress in the development of therapies for relapsing MS, progressive MS remains comparatively disappointing. Our objective, in this paper, is to review the current challenges in developing therapies for progressive MS and identify key priority areas for research. A collaborative was convened by volunteer and staff leaders from several MS societies with the mission to expedite the development of effective disease-modifying and symptom management therapies for progressive forms of multiple sclerosis. Through a series of scientific and strategic planning meetings, the collaborative identified and developed new perspectives on five key priority areas for research: experimental models, identification and validation of targets and repurposing opportunities, proof-of-concept clinical trial strategies, clinical outcome measures, and symptom management and rehabilitation. Our conclusions, tackling the impediments in developing therapies for progressive MS will require an integrated, multi-disciplinary approach to enable effective translation of research into therapies for progressive MS. Engagement of the MS research community through an international effort is needed to address and fund these research priorities with the ultimate goal of expediting the development of disease-modifying and symptom-relief treatments for progressive MS. PMID:22917690

  9. ARGUS progress report 1982

    International Nuclear Information System (INIS)

    Darden, C.W. III.

    1982-01-01

    On September 7th, 1982, following four years of planning and construction, the magnetic solenoid detector ARGUS was moved into one of the two interaction regions of the electron-positron storage ring DORIS. A month later the ring started delivering luminosity for physics research, specifically, the study of the formation and decay of members of the Upsilon family of mesons. These mesons are bound states, b anti b, of the heaviest of the five known quarks and therefore of considerable interest. This report describes the progress made during the year from March 1982 to March 1983 with emphasis on the experience gained during the first running period

  10. HSX progress report

    International Nuclear Information System (INIS)

    1994-01-01

    Brief statements on the progress of the design and construction of the HSX experiment are reported. Topics covered include the modular and auxiliary coil systems, the coil support structure, vacuum vessel, the ECH system, the magnet power supply and site. The proposed budget for Year 2 (August 1, 1994 through July 31, 1995) is presented. The effects of a flat funding profile (based on Year 2 budget level of $1137K) on out-years and the HSX project schedule are discussed. The stretching out of the program to accommodate the reduced funding profile should result in only a slight delay in HSX operations

  11. Progress in optics

    CERN Document Server

    Wolf, Emil

    1977-01-01

    In the thirty-seven years that have gone by since the first volume of Progress in Optics was published, optics has become one of the most dynamic fields of science. At the time of inception of this series, the first lasers were only just becoming operational, holography was in its infancy, subjects such as fiber optics, integrated optics and optoelectronics did not exist and quantum optics was the domain of only a few physicists. The term photonics had not yet been coined. Today these fields are flourishing and have become areas of specialisation for many science and engineering students and n

  12. [Research progress on fascioliasis].

    Science.gov (United States)

    Liu, Qian; Cheng, Na; Zhou, Yan; Xu, Xue-Nian

    2013-06-01

    Fascioliasis is an important zoonosis caused by Fasciola spp. It can cause pathological damages to human liver and gallbladder, as well as economic loss in animal husbandry. Fascioliasis can be easily misdiagnosed with other hepatobiliary diseases. The appearance of resistance to triclabendazole is an issue problem for fascioliasis control. Therefore, research for better diagnostic methods, effective drugs and vaccines become to the focus of fascioliasis control. This article summarizes the progress on epidemiological status, diagnostic method, therapy, drug resistance, vaccine and omics of fascioliasis.

  13. Mathieu Progressive Waves

    Science.gov (United States)

    Andrei, B. Utkin

    2011-10-01

    A new family of exact solutions to the wave equation representing relatively undistorted progressive waves is constructed using separation of variables in the elliptic cylindrical coordinates and one of the Bateman transforms. The general form of this Bateman transform in an orthogonal curvilinear cylindrical coordinate system is discussed and a specific problem of physical feasibility of the obtained solutions, connected with their dependence on the cyclic coordinate, is addressed. The limiting case of zero eccentricity, in which the elliptic cylindrical coordinates turn into their circular cylindrical counterparts, is shown to correspond to the focused wave modes of the Bessel-Gauss type.

  14. Mathieu Progressive Waves

    International Nuclear Information System (INIS)

    Utkin, Andrei B.

    2011-01-01

    A new family of exact solutions to the wave equation representing relatively undistorted progressive waves is constructed using separation of variables in the elliptic cylindrical coordinates and one of the Bateman transforms. The general form of this Bateman transform in an orthogonal curvilinear cylindrical coordinate system is discussed and a specific problem of physical feasibility of the obtained solutions, connected with their dependence on the cyclic coordinate, is addressed. The limiting case of zero eccentricity, in which the elliptic cylindrical coordinates turn into their circular cylindrical counterparts, is shown to correspond to the focused wave modes of the Bessel-Gauss type. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

  15. TASCC Division progress report

    International Nuclear Information System (INIS)

    Hardy, J.C.

    1992-10-01

    The TASCC (Tandem Accelerator-Superconducting Cyclotron) facility is devoted to developing and providing beams for an experimental program of basic nuclear research. Beam was on target for 2901 hours during the period of interest. The cyclotron provided beam for 524 hours, and tandem beams were used for a total of 3940 hours. The most exciting experimental result was the first evidence of a rotational band with the characteristics of hyperdeformation: a ridge-valley structure in 152 Dy. This progress report details experimental results and instrumentation and facility development over the period. (L.L.) (refs., tabs., figs.)

  16. Progress in optics

    CERN Document Server

    Wolf, Emil

    2006-01-01

    In the thirty-seven years that have gone by since the first volume of Progress in Optics was published, optics has become one of the most dynamic fields of science. At the time of inception of this series, the first lasers were only just becoming operational, holography was in its infancy, subjects such as fiber optics, integrated optics and optoelectronics did not exist and quantum optics was the domain of only a few physicists. The term photonics had not yet been coined. Today these fields are flourishing and have become areas of specialisation for many science and engineering students and n

  17. Progress in nanophotonics 1

    Energy Technology Data Exchange (ETDEWEB)

    Ohtsu, Motoichi (ed.) [Tokyo Univ. (Japan). Graduate School of Engineering

    2011-07-01

    This book focuses on the recent progress in nanophotonics technology to be used to develop novel nano-optical devices, fabrication technology, and security systems. It begins with a review of the concept of dressed photons and applications to devices, fabrication, and systems; principles and applications. Further topics include: DNA process for quantum dot chain, photon enhanced emission microscopy, near field spectroscopy of metallic nanostructure, self-organized fabrication of composite semiconductor quantum dots, formation of metallic nanostructure, and nanophotonic information systems with security. These topics are reviewed by seven leading scientists. This overview is a variable resource for engineers and scientists working in the field of nanophotonics. (orig.)

  18. Progressive pseudorheumatoid dysplasia misdiagnosed as ...

    African Journals Online (AJOL)

    Progressive pseudorheumatoid dysplasia misdiagnosed as seronegative juvenile idiopathic arthritis. Ozgur Taspinar, Fatih Kelesoglu, Yasar Keskin, Murat Uludag. Abstract. Background: Progressive pseudorheumatoid dysplasia (PPD) is a rare spondylo- epi-metaphyseal dysplasia (SEMD). It can be confused with juvenile ...

  19. Slowly progressive fluent aphasia

    International Nuclear Information System (INIS)

    Sakurai, Yasuhisa; Momose, Toshimitsu; Watanabe, Toshiaki; Ishikawa, Takashi; Iwata, Makoto; Bando, Mitsuaki.

    1991-01-01

    Three patients with slowly progressive fluent aphasia are reported. One of the patients presented with memory disturbance. They were characterized clinically by having selective deficits in vocabulary, which resulted in impairment of confrontation naming, and auditory comprehension. MRI showed an atrophy not only in the left temporal lobe (including the superior, middle and inferior temporal gyri), hippocampus, parahippocampual gyrus, and fusiform gyrus, but also in the left parietal lobe. I-123 IMP SPECT and F-18 FDG PET were used to determine regional cerebral blood flow and regional cerebral metabolic rate, respectively. In addition to the decreased tracer uptake in the left temporal and/or parietal lobe, a decreased uptake was seen in the bilateral basal ganglia, the inner side of the temporal lobe (including the bilateral hippocampus), the right anterior temporal lobe, and the left thalamus. These findings may deny the previous thought that lesions are localized in slowly progressive fluent aphasia. Furthermore, noticeable difficulty in naming, i.e., patients unable to recognize the right answer, are considered attributable to widespread lesions from the whole left temporal lobe, including the hippocampus, to the right temporal lobe. (N.K.)

  20. Progress in computational toxicology.

    Science.gov (United States)

    Ekins, Sean

    2014-01-01

    Computational methods have been widely applied to toxicology across pharmaceutical, consumer product and environmental fields over the past decade. Progress in computational toxicology is now reviewed. A literature review was performed on computational models for hepatotoxicity (e.g. for drug-induced liver injury (DILI)), cardiotoxicity, renal toxicity and genotoxicity. In addition various publications have been highlighted that use machine learning methods. Several computational toxicology model datasets from past publications were used to compare Bayesian and Support Vector Machine (SVM) learning methods. The increasing amounts of data for defined toxicology endpoints have enabled machine learning models that have been increasingly used for predictions. It is shown that across many different models Bayesian and SVM perform similarly based on cross validation data. Considerable progress has been made in computational toxicology in a decade in both model development and availability of larger scale or 'big data' models. The future efforts in toxicology data generation will likely provide us with hundreds of thousands of compounds that are readily accessible for machine learning models. These models will cover relevant chemistry space for pharmaceutical, consumer product and environmental applications. Copyright © 2013 Elsevier Inc. All rights reserved.

  1. Annual progress report

    International Nuclear Information System (INIS)

    Russek, A.

    1975-06-01

    Progress has been made in calculation of cross-sections for dielectronic and radiative recombination when hot electrons are incident on partially stripped impurity ions. Calculations were completed for the cases of 1 keV and 10 keV electrons incident on ions of arbitrary Z with ionization state consistent with a 1 keV plasma temperature. It was found that dielectronic recombination dominates radiative recombination by a factor of 100 at 1 keV incident electron energy to a factor of 1000 at 10 keV incident electron energy. The work is now being extended to other plasma temperatures and is being improved by more accurate calculation of the matrix elements involved. Progress was also made in the calculation of accurate bremsstrahlung and higher order radiative processes which also occur when hot electrons are incident on partially stripped impurity ions. Formal expressions for the matrix elements have been obtained for cross-sections in a fully relativistic partial wave analysis for bremsstrahlung radiation both with and without electron excitation of the target ion. Final evaluation now awaits the evaluation of the relativistic radial integrals involved in these matrix elements. (U.S.)

  2. Ghrelin and cancer progression.

    Science.gov (United States)

    Lin, Tsung-Chieh; Hsiao, Michael

    2017-08-01

    Ghrelin is a small peptide with 28 amino acids, and has been characterized as the ligand of the growth hormone secretagogue receptor (GHSR). In addition to its original function in stimulating pituitary growth hormone release, ghrelin is multifunctional and plays a role in the regulation of energy balance, gastric acid release, appetite, insulin secretion, gastric motility and the turnover of gastric and intestinal mucosa. The discovery of ghrelin and GHSR expression beyond normal tissues suggests its role other than physiological function. Emerging evidences have revealed ghrelin's function in regulating several processes related to cancer progression, especially in metastasis and proliferation. We further show the relative GHRL and GHSR expression in pan-cancers from The Cancer Genome Atlas (TCGA), suggesting the potential pathological role of the axis in cancers. This review focuses on ghrelin's biological function in cancer progression, and reveals its clinical significance especially the impact on cancer patient outcome. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  3. Annual progress report 1980

    International Nuclear Information System (INIS)

    1981-01-01

    The technical support activities of the IPSN to competent administrations in 1980 has been marked: namely by the authorizations of divergence for 9 units EdF-PWR of 900 MW, the authorization project of creation and extension of reprocessing plant of COGEMA at the Hague UP 2 -800 and the authorization of starting up of the third unit of production of the EURODIF enrichment plant at Tricastin. On the other hand, IPSN has participated at the elaboration of a certain number of legislative and regulation texts relative to the control of nuclear matter, to radioprotection standards and to criteria of safety. For the safety of breeder, the test made at CABRI pile, in the international research program has given confirmation of the validity of theoretical models used in accidents calculations, hypothetical accidents which has allowed to reactualize safety criteria which have to be used for the development of this type of reactor. In worker radioprotection the results obtained in laboratory on the effect of radon, the progress made in personal dosimetry and the action of radioprotection undertaken in uranium mines constitutes a coherent effort. The deep drilling in granit (1000 m) and the experimental associated program which has finished the indispensable scientific data for the future policy in matter of storage of radioactives wastes. IPSN has contributed to progress made in the rules of exploitation of reactors, in the definition of wastes containment -specially at the output of reprocessing plant- in handling machines in hazardeous areas and in the study of environment [fr

  4. Association for Progressive Communication : Institutional ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Monitoring Progress Toward the Information Society : Digital Divide Index. Orbicom's Digital Divide Index is a rigorous statistical tool for benchmarking access to and use of information and communication technologies (ICT), and monitoring progress toward the... View moreMonitoring Progress Toward the Information ...

  5. Progress in studies on nucleolus functions

    International Nuclear Information System (INIS)

    Chang Lei; Zhou Guangming

    2011-01-01

    Nucleoli is the sites for ribosome synthesis and processing, however, recent approaches have revealed that it is also involved in variety of cellular processes, especially the cellular stress response. As sensors, nucleoli regulate the localization of nucleolar proteins, such as (Alternate Reading Frame, ARF), and the activation of key factors, such as P53, and consequently mediate the cellular stress response.In this paper, recent progress in the studies on nucleolar functions in cellular stress response to radiation is reviewed. (authors)

  6. Evaluating progressive-rendering algorithms in appearance design tasks.

    Science.gov (United States)

    Jiawei Ou; Karlik, Ondrej; Křivánek, Jaroslav; Pellacini, Fabio

    2013-01-01

    Progressive rendering is becoming a popular alternative to precomputational approaches to appearance design. However, progressive algorithms create images exhibiting visual artifacts at early stages. A user study investigated these artifacts' effects on user performance in appearance design tasks. Novice and expert subjects performed lighting and material editing tasks with four algorithms: random path tracing, quasirandom path tracing, progressive photon mapping, and virtual-point-light rendering. Both the novices and experts strongly preferred path tracing to progressive photon mapping and virtual-point-light rendering. None of the participants preferred random path tracing to quasirandom path tracing or vice versa; the same situation held between progressive photon mapping and virtual-point-light rendering. The user workflow didn’t differ significantly with the four algorithms. The Web Extras include a video showing how four progressive-rendering algorithms converged (at http://youtu.be/ck-Gevl1e9s), the source code used, and other supplementary materials.

  7. Natural and man-made hexavalent chromium, Cr(VI), in groundwater near a mapped plume, Hinkley, California—study progress as of May 2017, and a summative-scale approach to estimate background Cr(VI) concentrations

    Science.gov (United States)

    Izbicki, John A.; Groover, Krishangi D.

    2018-03-22

    This report describes (1) work done between January 2015 and May 2017 as part of the U.S. Geological Survey (USGS) hexavalent chromium, Cr(VI), background study and (2) the summative-scale approach to be used to estimate the extent of anthropogenic (man-made) Cr(VI) and background Cr(VI) concentrations near the Pacific Gas and Electric Company (PG&E) natural gas compressor station in Hinkley, California. Most of the field work for the study was completed by May 2017. The summative-scale approach and calculation of Cr(VI) background were not well-defined at the time the USGS proposal for the background Cr(VI) study was prepared but have since been refined as a result of data collected as part of this study. The proposed summative scale consists of multiple items, formulated as questions to be answered at each sampled well. Questions that compose the summative scale were developed to address geologic, hydrologic, and geochemical constraints on Cr(VI) within the study area. Each question requires a binary (yes or no) answer. A score of 1 will be assigned for an answer that represents data consistent with anthropogenic Cr(VI); a score of –1 will be assigned for an answer that represents data inconsistent with anthropogenic Cr(VI). The areal extent of anthropogenic Cr(VI) estimated from the summative-scale analyses will be compared with the areal extent of anthropogenic Cr(VI) estimated on the basis of numerical groundwater flow model results, along with particle-tracking analyses. On the basis of these combined results, background Cr(VI) values will be estimated for “Mojave-type” deposits, and other deposits, in different parts of the study area outside the summative-scale mapped extent of anthropogenic Cr(VI).

  8. Progress report 1998

    International Nuclear Information System (INIS)

    1999-01-01

    The O.P.R.I. is in charge of environmental general surveillance and follow-up of natural exposures; To monitor the nuclear installations, it carries out samples campaigns. The technical follow-up of medical installations concerns it too. The workers radiation protection as well as the public protection are in its attributions. We find in particular, three sanitary studies: about the North Cotentin, (the question of excess of leukemia or not, and due or not to the facility of La hague) Nogent-sur-Marne (the case of a nursery school built on a old factory using radium), and the situation of populations living in French Polynesia, areas that have worried the public with alarmist announcements published in newspapers. All the results relative to the radiations measurements for 1998 appear in this progress report. (N.C.)

  9. Progress report 1981 - 1983

    International Nuclear Information System (INIS)

    Eder, G.; Rauch, H.; Balcar, E.; Buchtela, K.; Schwertfuehrer, W.; Vana, N.

    1984-06-01

    This progress report describes the research activities of the Atom-institute of the Austrian Universities of the period 1981-1983. The chapter headings are: (1) Electron- and X-ray physics, thermoluminescence and archeometry. (2) Nuclear physics. (3) Nuclear techniques, electronics and EDP. (4) Neutron- and solid state physics with neutron scattering, low temperature physics, theoretical solid state physics and preparation technique. (5) Radiation chemistry. (6) Radiation protection and dosimetry. Each chapter gives a comprimated overview about the research work done in the described period, illustrated by diagrams and tables, a comprehensive list of publications, each citation provided with an (mostly English) Abstract and a comprehensive list of thesis, which are completed or under preparation in the corresponding working group. Additional chapters give lists of educational work, verbal presentation, cooperations with other institutions and personnel. An annex of photos gives an additional impression of the institute. (A.N.)

  10. Progressing batch hydrolysis process

    Science.gov (United States)

    Wright, J.D.

    1985-01-10

    A progressive batch hydrolysis process is disclosed for producing sugar from a lignocellulosic feedstock. It comprises passing a stream of dilute acid serially through a plurality of percolation hydrolysis reactors charged with feed stock, at a flow rate, temperature and pressure sufficient to substantially convert all the cellulose component of the feed stock to glucose. The cooled dilute acid stream containing glucose, after exiting the last percolation hydrolysis reactor, serially fed through a plurality of pre-hydrolysis percolation reactors, charged with said feedstock, at a flow rate, temperature and pressure sufficient to substantially convert all the hemicellulose component of said feedstock to glucose. The dilute acid stream containing glucose is cooled after it exits the last prehydrolysis reactor.

  11. Progressive amusia and aprosody.

    Science.gov (United States)

    Confavreux, C; Croisile, B; Garassus, P; Aimard, G; Trillet, M

    1992-09-01

    We report a case of slowly progressive amusia and aprosody in association with orofacial and eyelid apraxias. The patient was independent in daily living activities. Insight, judgment, and behavior were intact. Her language was normal, and she demonstrated no limb, dressing, or constructional apraxia. She had no prosopagnosia, no visuospatial disturbances, and no memory impairment. Imaging studies (computed tomography, magnetic resonance imaging, single photon emission computed tomography) indicated a selective disorder of the right frontal and temporal regions. Review of the literature shows an increasing number of reports of this degenerative syndrome affecting the left dominant hemisphere and language areas, whereas cases of the syndrome affecting the right hemisphere are rare. To our knowledge, this is the first case in which aprosody and amusia were associated with a focal cortical degeneration.

  12. 1985. Progress annual report

    International Nuclear Information System (INIS)

    1986-06-01

    Tore Supra construction has been vigorously continued. The whole cryogenic system has been entirely delivered. On TFR priority has been given to electron cyclotron resonance heating; but also neutral heating mechanisms, pellet injection, plasma-wall interaction in the presence of pumped limiter, impurity transport and plasma turbulence have been studied and progress on diagnostics have been made. On Petula, with lower hybrid wave, the numerous results on ion heating, current drive, plasma stability in the presence of non-inductive current and on Tore Supra technical problems are important. At last, theoretical and numerical results are concerned with plasma equilibrium macroscopic evolution of plasma, RF heating, plasma instabilities, magnetic islands, turbulence, transport coefficients and spectroscopy [fr

  13. Vivitron - Progress report 1990

    International Nuclear Information System (INIS)

    1991-01-01

    The 1990 activity report of the Strasbourg Nuclear Research, concerning the Vivitron project, is presented. After having mounted all the Van de Graaff elements of the Vivitron needed for the generator tests, the tank was closed in July 1990. It was then put under vacuum, leaks were searched for and repaired. Voltage tests started in December and a voltage of 17.6 MV was reached in February. Modifications on the charging system and to improvement of the column protection against sparks are necessary before the voltage tests can be carried on. Great progress has been made in the setting up of the new Vivitron injector and analysing magnet. In this report are included the description of project different development steps, the Vivitron budget and the list of publications, congress contributions and internal reports. 18 figs

  14. Progressive brain compression

    International Nuclear Information System (INIS)

    Thuomas, K.AA.; Inst. of Surgical Research, National Hospital, Oslo; Vlajkovic, S.; Inst. of Surgical Research, National Hospital, Oslo; Ganz, J.C.; Inst. of Surgical Research, National Hospital, Oslo; Nilsson, P.; Inst. of Surgical Research, National Hospital, Oslo; Bergstroem, K.; Inst. of Surgical Research, National Hospital, Oslo; Ponten, U.; Inst. of Surgical Research, National Hospital, Oslo; Zwetnow, N.N.; Inst. of Surgical Research, National Hospital, Oslo

    1993-01-01

    Continuous recording of vital physiological variables and sequential MR imaging were performed simultaneously during continuous expansion of an epidural rubber balloon over the left hemisphere in anaesthetised dogs. Balloon expansion led to a progressive and slgithly nonlinear rise in intracranial CSF pressures and a full in local perfusion pressures. Changes in systemic arterial pressure, pulse rate, and respiration rate usually appeared at a balloon volume of 4% to 5% of the intracranial volume (reaction volume), together with a marked transtentorial pressure gradient and MR imaging changes consistent with tentorial herniation. Respiratory arrest occurred at a balloon volume of approximately 10% of the intracranial volume (apnoea volume), which was associated with occulsion of the cisterna magna, consistent with some degree of foramen magnum herniation. Increase in tissue water was observed beginning at approximately the reaction volume, presumably due to ischaemic oedema, due to the fall in perfusion pressures. (orig.)

  15. Muon collider progress

    Energy Technology Data Exchange (ETDEWEB)

    Noble, Robert J. FNAL

    1998-08-01

    Recent progress in the study of muon colliders is presented. An international collaboration consisting of over 100 individuals is involved in calculations and experiments to demonstrate the feasibility of this new type of lepton collider. Theoretical efforts are now concentrated on low-energy colliders in the 100 to 500 GeV center-of-mass energy range. Credible machine designs are emerging for much of a hypothetical complex from proton source to the final collider. Ionization cooling has been the most difficult part of the concept, and more powerful simulation tools are now in place to develop workable schemes. A collaboration proposal for a muon cooling experiment has been presented to the Fermilab Physics Advisory Committee, and a proposal for a targetry and pion collection channel experiment at Brookhaven National Laboratory is in preparation. Initial proton bunching and space-charge compensation experiments at existing hadron facilities have occurred to demonstrate proton driver feasibility.

  16. Progress in nanophotonics 3

    CERN Document Server

    Yatsui, Takashi

    2015-01-01

    This book focuses on the recent progress in nanophotonics technology to be used to develop novel nano-optical devices, fabrication technology and advanced systems. It reviews light-emitting diodes and lasers made of silicon bulk crystals in which the light emission principle is based on dressed-photon-phonons. Further topics include: theoretical studies of optoelectronic properties of molecular condensates for organic solar cells and light-emitting devices, the basics of topological light beams together with their important properties for laser spectroscopy, spatially localized modes emerging in nonlinear discrete dynamic systems and theoretical methods to explore the dynamics of nanoparticles by the light-induced force of tailored light fields under thermal fluctuations. These topics are reviewed by leading scientists. This overview is a variable resource for engineers and scientists working in the field of nanophotonics.

  17. Progress in nanophotonics 4

    CERN Document Server

    Yatsui, Takashi

    2017-01-01

    This book presents the recent progress in the field of nanophotonics. It contains review-like chapters focusing on various but mutually related topics in nanophotonics written by the world’s leading scientists. Following the elaboration of the idea of nanophotonics, much theoretical and experimental work has been carried out, and several novel photonic devices, high-resolution fabrication, highly efficient energy conversion, and novel information processing have been developed in these years. Novel theoretical models describing the nanometric light-matter interaction, nonequilibrium statistical mechanical models for photon breeding processes and near-field‐assisted chemical reactions as well as light‐matter interaction are also explained in this book. It describes dressed photon technology and its applications, including implementation of nanophotonic devices and systems, fabrication methods and performance characteristics of ultrathin, ultraflexible organic light‐emitting diodes, organic solar cells ...

  18. Progress Toward Attractive Stellarators

    International Nuclear Information System (INIS)

    Neilson, G.H.; Bromberg, L.; Brown, T.G.; Gates, D.A.; Ku, L.P.; Zarnstorff, M.C.; Boozer, A.H.; Harris, J.H.; Meneghini, O.; Mynick, H.E.; Pomphrey, N.; Reiman, A.H.; Xanthopoulos, P.

    2011-01-01

    The quasi-axisymmetric stellarator (QAS) concept offers a promising path to a more compact stellarator reactor, closer in linear dimensions to tokamak reactors than previous stellarator designs. Concept improvements are needed, however, to make it more maintainable and more compatible with high plant availability. Using the ARIES-CS design as a starting point, compact stellarator designs with improved maintenance characteristics have been developed. While the ARIES-CS features a through-the-port maintenance scheme, we have investigated configuration changes to enable a sector-maintenance approach, as envisioned for example in ARIES AT. Three approaches are reported. The first is to make tradeoffs within the QAS design space, giving greater emphasis to maintainability criteria. The second approach is to improve the optimization tools to more accurately and efficiently target the physics properties of importance. The third is to employ a hybrid coil topology, so that the plasma shaping functions of the main coils are shared more optimally, either with passive conductors made of high-temperature superconductor or with local compensation coils, allowing the main coils to become simpler. Optimization tools are being improved to test these approaches.

  19. Overlapping CD8+ and CD4+ T-cell epitopes identification for the progression of epitope-based peptide vaccine from nucleocapsid and glycoprotein of emerging Rift Valley fever virus using immunoinformatics approach.

    Science.gov (United States)

    Adhikari, Utpal Kumar; Rahman, M Mizanur

    2017-12-01

    Rift Valley fever virus (RVFV) is an emergent arthropod-borne zoonotic infectious viral pathogen which causes fatal diseases in the humans and ruminants. Currently, no effective and licensed vaccine is available for the prevention of RVFV infection in endemic as well as in non-endemic regions. So, an immunoinformatics-driven genome-wide screening approach was performed for the identification of overlapping CD8+ and CD4+ T-cell epitopes and also linear B-cell epitopes from the conserved sequences of the nucleocapsid (N) and glycoprotein (G) of RVFV. We identified overlapping 99.39% conserved 1 CD8+ T-cell epitope (MMHPSFAGM) from N protein and 100% conserved 7 epitopes (AVFALAPVV, LAVFALAPV, FALAPVVFA, VFALAPVVF, IAMTVLPAL, FFDWFSGLM, and FLLIYLGRT) from G protein and also identified IL-4 and IFN-γ induced (99.39% conserved) 1 N protein CD4+ T-cell epitope (HMMHPSFAGMVDPSL) and 100% conserved 5 G protein CD4+ T-cell epitopes (LPALAVFALAPVVFA, PALAVFALAPVVFAE, GIAMTVLPALAVFAL, GSWNFFDWFSGLMSW, and FFLLIYLGRTGLSKM). The overlapping CD8+ and CD4+ T-cell epitopes were bound with most conserved HLA-C*12:03 and HLA-DRB1*01:01, respectively with the high binding affinity (kcal/mol). The combined population coverage analysis revealed that the allele frequencies of these epitopes are high in endemic and non-endemic regions. Besides, we found 100% conserved and non-allergenic 2 decamer B-cell epitopes, GVCEVGVQAL and RVFNCIDWVH of G protein had the sequence similarity with the nonamer CD8+ T-cell epitopes, VCEVGVQAL and RVFNCIDWV, respectively. Consequently, these epitopes may be used for the development of epitope-based peptide vaccine against emerging RVFV. However, in vivo and in vitro experiments are required for their efficient use as a vaccine. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. A Road Map for Learning Progressions Research in Geography

    Science.gov (United States)

    Huynh, Niem Tu; Solem, Michael; Bednarz, Sarah Witham

    2015-01-01

    This article provides an overview of learning progressions (LP) and assesses the potential of this line of research to improve geography education. It presents the merits and limitations of three of the most common approaches used to conduct LP research and draws on one approach to propose a first draft of a LP on map reading and interpretation.…

  1. Measuring quality progress

    Science.gov (United States)

    Lambert, Larry D.

    The study by the American Productivity & Quality Center (APQC) was commissioned by Loral Space Information Systems, Inc. and the National Aeronautics and Space Administration (NASA) to evaluate internal assessment systems. APQC benchmarked approaches to the internal assessment of quality management systems in three phases. The first phase included work conducted for the International Benchmarking Clearinghouse (IBC) and consisted of an in-depth analysis of the 1991 Malcolm Baldrige National Quality Award criteria. The second phase was also performed for the IBC and compared the 1991 award criteria among the following quality awards: Deming Prize, Malcolm Baldrige National Quality Award, The President's Award for Quality and Productivity Improvement, The NASA Excellence Award (The George M. Lowe Trophy) for Quality and Productivity Improvement and the Shigeo Shingo Award for Excellence in Manufacturing. The third phase compared the internal implementation approaches of 23 companies selected from American industry for their recognized, formal assessment systems.

  2. Measuring quality progress

    Science.gov (United States)

    Lambert, Larry D.

    1992-01-01

    The study by the American Productivity & Quality Center (APQC) was commissioned by Loral Space Information Systems, Inc. and the National Aeronautics and Space Administration (NASA) to evaluate internal assessment systems. APQC benchmarked approaches to the internal assessment of quality management systems in three phases. The first phase included work conducted for the International Benchmarking Clearinghouse (IBC) and consisted of an in-depth analysis of the 1991 Malcolm Baldrige National Quality Award criteria. The second phase was also performed for the IBC and compared the 1991 award criteria among the following quality awards: Deming Prize, Malcolm Baldrige National Quality Award, The President's Award for Quality and Productivity Improvement, The NASA Excellence Award (The George M. Lowe Trophy) for Quality and Productivity Improvement and the Shigeo Shingo Award for Excellence in Manufacturing. The third phase compared the internal implementation approaches of 23 companies selected from American industry for their recognized, formal assessment systems.

  3. ALARA: Progress and prospects

    International Nuclear Information System (INIS)

    Khan, T.A.; Baum, J.W.

    1988-01-01

    This paper has two main topics. The first part describes the establishment and work of the ALARA Center; the second part presents some results of studies at the Center with international data on doses at PWR plants. This data then is used to reach a preliminary understanding of some of the factors that are causing high doses at PWRs. This approach should help in reducing occupational exposures in a more effective manner

  4. IPY Progress and Prospects

    Science.gov (United States)

    Carlson, D.

    2008-12-01

    We can summarize the IPY goals as: (a) make major advances in polar knowledge and understanding; (b) leave a legacy of new or enhanced observational systems, facilities and infrastructure; (c) excite a new generation of polar scientists and engineers, and (d) elicit exceptional interest and participation from polar residents, schoolchildren, the general public, and decision-makers, worldwide. This talk reports on the progress and prospects in each of those areas from an overall international view; separate talks will describe details of future researcher and the IPY outreach efforts. To achieve major advances in knowledge, IPY has entrained the intellectual resources of thousands of scientists, many more than expected, often from 'non- polar' nations, and representing an unprecedented breadth of scientific specialties; integration of those efforts across disciplines to achieve integrated system-level understanding remains a substantial challenge. Many national and international organizations prepare plans to sustain new and improved observational systems, but clear outcomes and the necessary resources remain elusive. International outreach networks gradually build breadth and strength, largely through IPY Polar Science Days and other internationally- coordinated IPY events. A new Association of Polar Early Career Scientists (APECS) devotes talent and energy to shaping the future of polar research. These activities and networks may, with time and with continued international coordination, achieve an exceptional level of interest and participation. In all areas, much work remains.

  5. CERN: LHC progress

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    The push for CERN's next major project, the LHC proton collider to be built in the 27-kilometre LEP tunnel, is advancing on a wide front. For the machine itself, there has been considerable progress in the detailed design. While the main thrust is for proton-proton collisions, heavy ions are also on the LHC collision menu. On the experimental side, proposals are coming into sharper focus. For the machine, the main aim is for the highest possible proton collision energies and collision rates in the confines of the existing LEP tunnel, and the original base design looked to achieve these goals in three collision regions. Early discussions on the experimental programme quickly established that the most probable configuration would have two collision regions rather than three. This, combined with hints that the electronics of several detectors would have to handle several bunch crossings at a time, raised the question whether the originally specified bunch spacing of 15 ns was still optimal

  6. Progress in neuromorphic photonics

    Science.gov (United States)

    Ferreira de Lima, Thomas; Shastri, Bhavin J.; Tait, Alexander N.; Nahmias, Mitchell A.; Prucnal, Paul R.

    2017-03-01

    As society's appetite for information continues to grow, so does our need to process this information with increasing speed and versatility. Many believe that the one-size-fits-all solution of digital electronics is becoming a limiting factor in certain areas such as data links, cognitive radio, and ultrafast control. Analog photonic devices have found relatively simple signal processing niches where electronics can no longer provide sufficient speed and reconfigurability. Recently, the landscape for commercially manufacturable photonic chips has been changing rapidly and now promises to achieve economies of scale previously enjoyed solely by microelectronics. By bridging the mathematical prowess of artificial neural networks to the underlying physics of optoelectronic devices, neuromorphic photonics could breach new domains of information processing demanding significant complexity, low cost, and unmatched speed. In this article, we review the progress in neuromorphic photonics, focusing on photonic integrated devices. The challenges and design rules for optoelectronic instantiation of artificial neurons are presented. The proposed photonic architecture revolves around the processing network node composed of two parts: a nonlinear element and a network interface. We then survey excitable lasers in the recent literature as candidates for the nonlinear node and microring-resonator weight banks as the network interface. Finally, we compare metrics between neuromorphic electronics and neuromorphic photonics and discuss potential applications.

  7. Progress report, 1982

    International Nuclear Information System (INIS)

    1982-01-01

    The report describes a number of areas of research at the TRIUMPH facility. Substantial progress has been made in the experiment to measure charge symmetry breaking in the n-p system. The investigations on polarized nucleon radiative capture on light nuclei have been ongoing with results of the excitation function for p + d→γ + 3 He reaction being published. Studies of the n + p→d + γ reactions are continuing. Results have been obtained in the determination of structure in the three nucleon system by studying the reaction anti d + p using tensor polarized deuterons. The Wolfenstein R-parameter in proton - 4 He elastic scattering has been measured at 500 MeV from 15 to 50 degrees (lab.) using the focal plane polarimeter on the MRS. Other experiments involving quasi-elastic scattering of polarized protons at 300 MeV, fission evaporation competition in heavy nuclei and proton-proton bremsstrahlung have been carried out. The status of the Bevelac heavy ion collaboration and the MWPC facility is also included

  8. Progressive myoclonic epilepsies

    Science.gov (United States)

    Michelucci, Roberto; Canafoglia, Laura; Striano, Pasquale; Gambardella, Antonio; Magaudda, Adriana; Tinuper, Paolo; La Neve, Angela; Ferlazzo, Edoardo; Gobbi, Giuseppe; Giallonardo, Anna Teresa; Capovilla, Giuseppe; Visani, Elisa; Panzica, Ferruccio; Avanzini, Giuliano; Tassinari, Carlo Alberto; Bianchi, Amedeo; Zara, Federico

    2014-01-01

    Objective: To define the clinical spectrum and etiology of progressive myoclonic epilepsies (PMEs) in Italy using a database developed by the Genetics Commission of the Italian League against Epilepsy. Methods: We collected clinical and laboratory data from patients referred to 25 Italian epilepsy centers regardless of whether a positive causative factor was identified. PMEs of undetermined origins were grouped using 2-step cluster analysis. Results: We collected clinical data from 204 patients, including 77 with a diagnosis of Unverricht-Lundborg disease and 37 with a diagnosis of Lafora body disease; 31 patients had PMEs due to rarer genetic causes, mainly neuronal ceroid lipofuscinoses. Two more patients had celiac disease. Despite extensive investigation, we found no definitive etiology for 57 patients. Cluster analysis indicated that these patients could be grouped into 2 clusters defined by age at disease onset, age at myoclonus onset, previous psychomotor delay, seizure characteristics, photosensitivity, associated signs other than those included in the cardinal definition of PME, and pathologic MRI findings. Conclusions: Information concerning the distribution of different genetic causes of PMEs may provide a framework for an updated diagnostic workup. Phenotypes of the patients with PME of undetermined cause varied widely. The presence of separate clusters suggests that novel forms of PME are yet to be clinically and genetically characterized. PMID:24384641

  9. Technical progress report

    International Nuclear Information System (INIS)

    1996-01-01

    This report summarizes experimental and theoretical work in basic nuclear physics carried out between October 1, 1995, the closing of our last Progress Report, and September 30, 1996 at the Nuclear Physics Laboratory of the University of Colorado, Boulder, under contracts DE-FG03-93ER-40774 and DE-FG03-95ER-40913 with the United States Department of Energy. The experimental contract supports broadly-based experimental research in intermediate energy nuclear physics. This report includes results from studies of Elementary Systems involving the study of the structure of the nucleon via polarized high-energy positron scattering (the HERMES experiment) and lower energy pion scattering from both polarized and unpolarized nucleon targets. Results from pion- and kaon-induced reactions in a variety of nuclear systems are reported under the section heading Meson Reactions; the impact of these and other results on understanding the nucleus is presented in the Nuclear Structure section. In addition, new results from scattering of high-energy electrons (from CEBAF/TJNAF) and pions (from KEK) from a broad range of nuclei are reported in the section on Incoherent Reactions. Finally, the development and performance of detectors produced by the laboratory are described in the section titled Instrumentation

  10. Resistance to technological progress

    International Nuclear Information System (INIS)

    Isensee, J.

    1983-01-01

    This article deals with the tolerance test the constitutional system (Basic Law) of the Federal Republic of Germany is currently put to as a consequence of the resistance to the power structure of this country, which is expressed in the name of protection and defense for the environment and world peace. This biopacifistic resistance movment, the author says, has nothing to do with the legal right to resist, as laid down in art. 20 (4) of the Basic Law. According to the author, this attitude is an offspring of fear of the hazards of technological progress, primarily of nuclear hazards. Practical resistance, the author states, is preceded by theoretical resistance in speech: De-legitimation of the democratic legality, of the parliamentary functions, of the supreme power of the government, and denial of the citizens duty of obedience. The author raises the question as to whether this attitude of disobedience on ecological grounds marks the onset of a fourth stage of development of the modern state, after we have passed through stages characterised by fear of civil war, of tyranny, and of social privation and suffering. There are no new ideas brought forward by the ecologically minded movement, the author says, for re-shaping our institutions or constitutional system. (HP) [de

  11. Hybrid antibiotics - clinical progress and novel designs.

    Science.gov (United States)

    Parkes, Alastair L; Yule, Ian A

    2016-07-01

    There is a growing need for new antibacterial agents, but success in development of antibiotics in recent years has been limited. This has led researchers to investigate novel approaches to finding compounds that are effective against multi-drug resistant bacteria, and that delay onset of resistance. One such strategy has been to link antibiotics to produce hybrids designed to overcome resistance mechanisms. The concept of dual-acting hybrid antibiotics was introduced and reviewed in this journal in 2010. In the present review the authors sought to discover how clinical candidates described had progressed, and to examine how the field has developed. In three sections the authors cover the clinical progress of hybrid antibiotics, novel agents produced from hybridisation of two or more small-molecule antibiotics, and novel agents produced from hybridisation of antibiotics with small-molecules that have complementary activity. Many key questions regarding dual-acting hybrid antibiotics remain to be answered, and the proposed benefits of this approach are yet to be demonstrated. While Cadazolid in particular continues to progress in the clinic, suggesting that there is promise in hybridisation through covalent linkage, it may be that properties other than antibacterial activity are key when choosing a partner molecule.

  12. Progress in fusion

    International Nuclear Information System (INIS)

    1959-01-01

    thermonuclear research, the work was being conducted on more or less similar lines, the basic problems encountered were the same and the results obtained were strikingly similar. Commenting on this fact, Professor Edward Teller of the United States said: 'it is remarkable how closely parallel the developments are. This is of course due to the fact that we all live in the same world and all obey the same laws of nature'. And this underlined, more than ever before, the need for a wide exchange of knowledge and experience so that duplication of effort could be avoided and progress made quicker by a pooling of information on the latest experimental results and theoretical deductions. A major concrete step in this direction has been taken by the Scientific Advisory Committee of the International Atomic Energy Agency, which recommended that the Agency should serve as the world focal point for the exchange of information on progress in thermonuclear research and plasma physics. Among the Committee's specific recommendations was that the Agency should start a scientific journal devoted exclusively to this subject. The proposed journal is expected to make its first appearance next year. It will contain, among other things, original papers on theoretical and applied research as well as on related engineering developments. Also the need arises for a permanent forum need will be met in large measure by IAEA's programme of work in this field

  13. Medulloblastoma: progress over time

    International Nuclear Information System (INIS)

    Smee, Robert I.; Williams, Janet R.; De-loyde, Katie J.; Meagher, Nicola S.; Cohn, Richard

    2012-01-01

    Medulloblastoma is the most common central nervous system tumour in children aged 0–4 years, with 75% of cases occurring in patients <16 years, and rare in adults. The intent of this audit is to review a single centre's experience and to compare outcomes with other centres' outcomes. This Ethics approved retrospective audit evaluates the paediatric population aged <16 years who received radiotherapy as their initial or salvage treatment at the Prince of Wales Hospital Cancer Centre between 1972 and 2007. The primary and secondary end-points were progression-free survival (PFS) and cancer-specific survival (CSS), with comparisons made between patients treated before and after 1990, and the impact of high- and low-risk disease. There were 80 eligible patients, 78 who had radiotherapy at initial presentation, and 2 at the time of recurrence. Median age was 6.5 years, 52 were boys and 28 were girls. Seventy-eight patients had a surgical procedure and ultimately received craniospinal radiotherapy. Of these 78 patients, 32 (40%) had a macroscopically complete resection. The 5-year PFS was 69.7%. The 5-year PFS for patients treated pre and post 1990 was 66.1% and 71.8%, respectively. The 5-year CSS for high- and low-risk patients was 61.1% and 78.4%, respectively. Ultimately, 33% of patients were dead due to disease. This audit demonstrates those children referred to this facility for treatment have comparable survival to that of other major centres.

  14. 2004 Progress Report

    International Nuclear Information System (INIS)

    Batistoni, Paola; De Marco, Francesco; Pieroni, Leonardo

    2005-01-01

    Fusion research is undertaken all over the world with the objective of realising an environmentally responsible source of energy with essentially unlimited and widely distributed fuel reserves. The results of the worldwide efforts made in recent years are now embodied in ITER, the International Thermonuclear Experimental Reactor, designed to produce at least 500 MW of fusion power with a power gain of ten. ITER will test for the first time the interaction of fusion plasma physics with power station technology. In this international framework, during 2004 Fusion Technical and Scientific Unit of ENEA obtained important results in several keys areas. At the Frascati Tokamak Upgrade the lower hybrid microwave system was fully exploited to study the generation and control of the plasma current, and the electron cyclotron heating system reached full power (1.5 MW). With the simultaneous injection of the two waves, good energy confinement regimes with internal transport barriers were obtained at the highest plasma densities ever achieved. Advanced scenario regimes were also addressed in the activities of ENEA at JET. The engineering design of the IGNITOR machine was finalised, and significant progress was made in understanding the plasma physics regimes. Among the technology activities, the qualification of the deposition process of a copper liner on carbon fibre composite (CFC) hollow tiles may be mentioned as the most important achievement. This innovative pre brazed casting process is a competitive candidate for the fabrication of the CFCbased ITER divertor components. ENEA participated in the European activity for the definition and production on an industrial scale of an advanced Nb3Sn strand for the ITER superconducting central solenoid and toroidal field coils. Contributions were also made to the design of the final conductor layout and the characterisation tests. Inertial fusion studies continued along the previous lines, namely, the study of the implosion

  15. 1997 Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Cecchini, M.; Crescentini, L.; Ghezzi, L. [ENEA, Centro Ricerche Frascati, Rome (Italy). Nuclear fusion division

    1997-12-31

    1997 was another year of intense activity for the ENEA Nuclear Fusion Division in the evolving scenario of fusion research. With respect to the International Thermonuclear Experimental Reactor (ITER), a major review process has started, originate by the wide perception that the difficult financial situation affecting some of the parties would make it very difficult, practically impossible, to secure funding for the project as it stands. To scale down the size and cost of the machine by reducing the technical objectives, while keeping to the programmatic goal of constructing a demonstration reactor (DEMO) as the following step, appears achievable. Progress in physics was substantial during 1997. Analysis of the huge existing database, complemented by the latest results, had led to a better, more accurate scaling for the confinement time on which to base extrapolation to ITER. Studies of the very promising advanced regimes have been pursued on many tokamaks. The Frascati Tokamak Upgrade (FTU) is well placed in this respect since it is equipped with the right tools, lower hybrid and electron cyclotron radiofrequency heating and current drive systems, to explore the new promised land of low transport from the plasma core. The main highlights of FTU operation in 1997 were related to providing information relevant to these future developments. Transient production of low transport regimes with electron temperatures of 8-9 keV at the plasma center was obtained by taking advantage of the plasma skin effect and precise electron cyclotron power deposition. High-efficiency current drive at high density using lower hybrid waves was demonstrated. High-confinement pellet-enhanced modes of operation and good ion Bernstein wave coupling through the waveguide-type coupler were also achieved. Concerning the IGNITOR experiment, funds were made available only for continuation of the engineering design activities, and nothing has been released so far for manufacturing the additional

  16. 2004 Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Batistoni, Paola; De Marco, Francesco; Pieroni, Leonardo [ed.

    2005-07-01

    Fusion research is undertaken all over the world with the objective of realising an environmentally responsible source of energy with essentially unlimited and widely distributed fuel reserves. The results of the worldwide efforts made in recent years are now embodied in ITER, the International Thermonuclear Experimental Reactor, designed to produce at least 500 MW of fusion power with a power gain of ten. ITER will test for the first time the interaction of fusion plasma physics with power station technology. In this international framework, during 2004 Fusion Technical and Scientific Unit of ENEA obtained important results in several keys areas. At the Frascati Tokamak Upgrade the lower hybrid microwave system was fully exploited to study the generation and control of the plasma current, and the electron cyclotron heating system reached full power (1.5 MW). With the simultaneous injection of the two waves, good energy confinement regimes with internal transport barriers were obtained at the highest plasma densities ever achieved. Advanced scenario regimes were also addressed in the activities of ENEA at JET. The engineering design of the IGNITOR machine was finalised, and significant progress was made in understanding the plasma physics regimes. Among the technology activities, the qualification of the deposition process of a copper liner on carbon fibre composite (CFC) hollow tiles may be mentioned as the most important achievement. This innovative pre brazed casting process is a competitive candidate for the fabrication of the CFCbased ITER divertor components. ENEA participated in the European activity for the definition and production on an industrial scale of an advanced Nb3Sn strand for the ITER superconducting central solenoid and toroidal field coils. Contributions were also made to the design of the final conductor layout and the characterisation tests. Inertial fusion studies continued along the previous lines, namely, the study of the implosion

  17. 1997 Progress report

    International Nuclear Information System (INIS)

    Cecchini, M.; Crescentini, L.; Ghezzi, L.

    1997-01-01

    1997 was another year of intense activity for the ENEA Nuclear Fusion Division in the evolving scenario of fusion research. With respect to the International Thermonuclear Experimental Reactor (ITER), a major review process has started, originate by the wide perception that the difficult financial situation affecting some of the parties would make it very difficult, practically impossible, to secure funding for the project as it stands. To scale down the size and cost of the machine by reducing the technical objectives, while keeping to the programmatic goal of constructing a demonstration reactor (DEMO) as the following step, appears achievable. Progress in physics was substantial during 1997. Analysis of the huge existing database, complemented by the latest results, had led to a better, more accurate scaling for the confinement time on which to base extrapolation to ITER. Studies of the very promising advanced regimes have been pursued on many tokamaks. The Frascati Tokamak Upgrade (FTU) is well placed in this respect since it is equipped with the right tools, lower hybrid and electron cyclotron radiofrequency heating and current drive systems, to explore the new promised land of low transport from the plasma core. The main highlights of FTU operation in 1997 were related to providing information relevant to these future developments. Transient production of low transport regimes with electron temperatures of 8-9 keV at the plasma center was obtained by taking advantage of the plasma skin effect and precise electron cyclotron power deposition. High-efficiency current drive at high density using lower hybrid waves was demonstrated. High-confinement pellet-enhanced modes of operation and good ion Bernstein wave coupling through the waveguide-type coupler were also achieved. Concerning the IGNITOR experiment, funds were made available only for continuation of the engineering design activities, and nothing has been released so far for manufacturing the additional

  18. HYLIFE-2 progress report

    International Nuclear Information System (INIS)

    Moir, R.W.; Adamson, M.G.; Bangerter, R.O.; Bieri, R.L.; Condit, R.H.; Hartman, C.W.; House, P.A.; Langdon, A.B.; Logan, B.G.; Orth, C.D.; Petzoldt, R.W.; Pitts, J.H.; Post, R.F.; Sacks, R.A.; Tobin, M.T.; Williams, W.H.; Dolan, T.J.; Longhurst, G.R.; Hoffman, M.A.; Meier, W.R.

    1991-12-01

    LIFE-II inertial confinement fusion power plant design study uses a liquid fall, in the form of jets to protect the first structural wall from neutron damage, x rays, and blast to provide a 30-y lifetime. This is a progress report of an incomplete and ongoing study. HYLIFE-I used liquid lithium. HYLIFE-11 avoids the fire hazard of lithium by using a molten salt composed of fluorine, lithium, and beryllium (Li 2 Be 4 ) called Flibe. Access for heavy-ion beams is provided. Calculations for assumed heavy-ion beam performance show a nominal gain of 70 at 5 MJ producing 350 MJ, about 5.2 times less yield than the 1.8 GJ from a driver energy of 4.5 MJ with gain of 400 for HYLIFE-I. The nominal 1 GWe of power can be maintained by increasing the repetition rate by a factor of about 5.2, from 1.5 to 8 Hz. A higher repetition rate requires faster re-establishment of the jets after a shot, which can be accomplished in part by decreasing the jet fall height and increasing the jet flow velocity. Multiple chambers may be required.In addition, although not considered for HYLIFE-I there is undoubtedly liquid splash that must be forcibly cleared because gravity is too slow, especially at high repetition rates. Splash removal can be accomplished by either pulsed or oscillating jet flows. The cost of electricity is estimated to be 0.10 $/kW· in constant 1990 dollars, about twice that of future coal and light water reactor nuclear power. The driver beam cost is about one-half the total cost

  19. Progress report 2000

    International Nuclear Information System (INIS)

    2001-01-01

    Clean Air Hamilton is the new name of the Hamilton-Wentworth Air Quality Initiative and its implementation committee, which began in 1995 as a collaborative, multi-sectoral effort to identify and examine important air quality issues and to implement strategies to reduce many of the harmful emissions that endanger human health. During the year 2000 Clean Air Hamilton focused on nine program areas. Strategies were initiated to (1) reduce single occupancy auto trips, (2) purchase low emission vehicles, (3) model transportation emissions, (4) reduce smog-causing emissions, (5) plant trees, (6) provide advice on air quality related land use and transportation issues for consideration in city-wide planning, (7) promote public awareness through social marketing, (8) study fugitive road dust, and (9) reduce transboundary air pollution. A number of indicators to measure progress in efforts to improve air quality have been developed; many of these indicators show significant improvements which, taken collectively, show a positive trend toward cleaner air. The report highlights major accomplishment of Clean Air Hamilton; reports trends in ambient air quality data; assesses human health impacts of air quality, and recommends strategies for further improvements. Among major improvements, inhalable particulate (PM10) levels have decreased by about 20 per cent since 1991; sulphur dioxide levels dropped by 40 per cent since 1989 at industrial sampling sites and 20 per cent at the downtown sampling site; the air pollution index has remained under the advisory level of 32 at all API stations in Hamilton since June 1996. Benzene levels in air decreased by over 50 per cent near the Dofasco plant compared to the five-year composite average from 1994-1998. Given these accomplishments, participants in Clean Air Hamilton believe that while there is much room for improvement, the efforts to date have been worthwhile and provide encouragement for the future. 14 figs., 4 appendices

  20. 1997 Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Cecchini, M; Crescentini, L; Ghezzi, L [ENEA, Centro Ricerche Frascati, Rome (Italy). Nuclear fusion division

    1998-12-31

    1997 was another year of intense activity for the ENEA Nuclear Fusion Division in the evolving scenario of fusion research. With respect to the International Thermonuclear Experimental Reactor (ITER), a major review process has started, originate by the wide perception that the difficult financial situation affecting some of the parties would make it very difficult, practically impossible, to secure funding for the project as it stands. To scale down the size and cost of the machine by reducing the technical objectives, while keeping to the programmatic goal of constructing a demonstration reactor (DEMO) as the following step, appears achievable. Progress in physics was substantial during 1997. Analysis of the huge existing database, complemented by the latest results, had led to a better, more accurate scaling for the confinement time on which to base extrapolation to ITER. Studies of the very promising advanced regimes have been pursued on many tokamaks. The Frascati Tokamak Upgrade (FTU) is well placed in this respect since it is equipped with the right tools, lower hybrid and electron cyclotron radiofrequency heating and current drive systems, to explore the new promised land of low transport from the plasma core. The main highlights of FTU operation in 1997 were related to providing information relevant to these future developments. Transient production of low transport regimes with electron temperatures of 8-9 keV at the plasma center was obtained by taking advantage of the plasma skin effect and precise electron cyclotron power deposition. High-efficiency current drive at high density using lower hybrid waves was demonstrated. High-confinement pellet-enhanced modes of operation and good ion Bernstein wave coupling through the waveguide-type coupler were also achieved. Concerning the IGNITOR experiment, funds were made available only for continuation of the engineering design activities, and nothing has been released so far for manufacturing the additional

  1. Supersymmetric inflation: Recent progress

    International Nuclear Information System (INIS)

    Ovrut, B.A.; Steinhardt, P.J.

    1986-01-01

    The new inflationary universe scenario is, in principle, a simple and powerful approach to resolving a large number of fundamental cosmological problems. However, in order for the scenario to be considered a complete theory, one critical question remains to be answered: What is the physics responsible for the phase transition that triggers the exponential expansion (inflation) of the universe? One possibility that the authors and several other groups have been pursuing is that the physics responsible for the phase transition involves (local) supersymmetry. The goal of this paper is to review the present status of ''Supersymmetric Inflation'', particularly emphasizing some very exciting results that they recently obtained

  2. Research progress on osteoarthritis treatment mechanisms.

    Science.gov (United States)

    Gu, Yun-Tao; Chen, Jian; Meng, Zhu-Long; Ge, Wan-Yu; Bian, Yang-Yang; Cheng, Shao-Wen; Xing, Chen-Kun; Yao, Jiang-Ling; Fu, Jian; Peng, Lei

    2017-09-01

    Osteoarthritis is a common disease and is frequently encountered in the older population; the incidence rises sharply with age. It is estimated that more than 360 million people suffer from OA. However, the pathogenesis of osteoarthritis remains unclear, and we cannot effectively prevent the progression of OA. The aim of this review was to explore the molecular markers and signaling pathways that induce chondrocyte apoptosis in OA. We searched, using the key words osteoarthritis, chondrocyte apoptosis, autophagy, endoplasmic reticulum stress, molecular targets, and biomarkers, in PubMed, Web of Science, and Google Scholar from 1994 to 2017. We also reviewed the signaling pathways and molecular markers associated with chondrocyte apoptosis and approaches aimed at inhibiting the apoptosis-inducing mechanism to at least delay the progression of cartilage degeneration in OA. This article provides an overview of targeted therapies and the related signaling pathways in OA. Copyright © 2017. Published by Elsevier Masson SAS.

  3. Progress on resolution of major surety issues

    International Nuclear Information System (INIS)

    Bell, C.R.; Boudreau, J.M.

    1985-01-01

    This paper presents a summary of the major surety issues (safety, environmental protection, sageguards, reliability, quality assurance) that have been identified during Phase I of the SP-100 Program and the progress that has been made in analyzing the most important of these issues in the context of the conceptual design effort. These issues have been identified as inadvertent criticality, toxic material release and dispersion, radiation exposure following end-of-life reentry, potential diversion of special nuclear material, failure to achieve end-of-life neutronic shutdown, and structural predictability for end-of-life re-entry or boost. Because of the complexity of these issues, a simplified conservative approach was taken during Phase I. Progress on these issues has been mainly in the area of increased understanding of the issues, identification of design features to resolve the issues, and quantitative evaluations of the surety characteristics of the various design concepts

  4. ADAPTATION AND PROGRESS THROUGH CHANGE MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Gabriela MEHEDINTU

    2016-12-01

    Full Text Available The technological progress, digitization and the explosion of information significantly change how individuals, the business environment, and society act, develop and add value. New, interdisciplinary approaches, constantly adapted and sustainable both at the micro and the macro levels are required. Within a company, change management is a systematic element of the strategic business process and involves the early identification of the opportunity of the employees’ development, courage, commitment and flexibility; under no circumstances should it be seen as a risk and instability factor, as it may be considered in the early stages. The example presented in this article proves that the openness to change and continuous improvement develops advantages, optimizes processes and sustains long-term progress.

  5. Opportunities for Collaborative Adaptive Management Progress: Integrating Stakeholder Assessments into Progress Measurement

    Directory of Open Access Journals (Sweden)

    Jim Berkley

    2013-12-01

    There are differences among stakeholders in the indicators they consider as relevant to the assessment of progress. Elucidating these differences can provide useful information about system components and relationships that are important to public support of a CAM program and progress. One of the sources of differences in progress assessments among stakeholders comes from their diverse perceptions about the desired and current states of the social-ecological systems. Stakeholder behavior can be inconsistent between group and individual settings. Individually they may make plans, based on their assessments, that do not conform to the group plan because of their unique interests and preferences. The results of this study need to be further tested. The framework should be used through multiple cycles to determine whether the information gathered with this approach results in additional progress as compared with past approaches. In particular, it would be helpful to test whether gathering such information resulted in a decrease in stakeholders electing to go outside of the CAM process to get their needs met.

  6. Mechanical control of mitotic progression in single animal cells

    OpenAIRE

    Cattin, Cedric J.; Düggelin, Marcel; Martinez-Martin, David; Gerber, Christoph; Müller, Daniel J.; Stewart, Martin P.

    2015-01-01

    Despite the importance of mitotic cell rounding in tissue development and cell proliferation, there remains a paucity of approaches to investigate the mechanical robustness of cell rounding. Here we introduce ion beam-sculpted microcantilevers that enable precise force-feedback-controlled confinement of single cells while characterizing their progression through mitosis. We identify three force regimes according to the cell response: small forces (∼5 nN) that accelerate mitotic progression, i...

  7. Interleukin-30: A novel microenvironmental hallmark of prostate cancer progression.

    Science.gov (United States)

    Di Carlo, Emma

    2014-01-01

    Metastatic prostate cancer is a leading cause of cancer-related death in men worldwide. We have recently discovered that IL-30 shapes the microenvironment of prostate cancer and tumor-draining lymph nodes to favor tumor progression. IL-30 supports tumor growth in vitro, and IL-30 expression in prostate cancer patients is associated with high tumor grade and metastatic stage of disease. Thus, IL-30 may constitute a valuable target for modern therapeutic approaches to hamper prostate cancer progression.

  8. Periodic progress report, 6 months

    DEFF Research Database (Denmark)

    Juhl, Thomas Winther; Nielsen, Jakob Skov

    This is the first progress report of the BriteEuram project named "High Power Laser Cutting for Heavy Industry" ("Powercut"). The report contains a summary of the objectives of the first period, an overview of the technical progress, a comparison between the planed and the accomplished work...

  9. Progress report. P6

    International Nuclear Information System (INIS)

    Manokhin, V.N.; Maev, S.A.

    2001-01-01

    In CJD the current work continued concerning EXFOR compilation and fulfillment of NRDC-2000 Recommendations and Actions. Much efforts were applied for restoring CJD Web page. Evaluation works were also in process. Compilation into EXFOR continues on steadily. Since March 2000 up to April 2001 four TRANS tapes containing 69 Entries were prepared and sent to other centers. 25 new EXFOR Entries were compiled. An analysis and an evaluation are made for the threshold reactions cross sections leading to production of the long-lived radioactive nuclides on the irradiation of steel by thermonuclear neutron spectrum. Fifty excitation functions were evaluated. Many of them are considerably different from available evaluations of other libraries. During two years, together with JAERI, comparative analysis was performed of (n,2n) and (n,3n) reactions for 150 fission products from available evaluated data libraries. The result of analysis will be published this year. The joint work on consistent evaluation of some (n,2n) and (n,np) excitation functions for even-even isotopes was made on the basis of empirical systematics. The work was completed on evaluation of the spectra and production cross sections of gamma-rays in inelastic interactions of 14-Mev neutrons with the number of nuclei: Li-6, Li-7, Al, Ti, Cr, Fe, Cu, Pb, Bi, U-235. CJD continues the work on evaluation of neutron data for minor actinides. This year Am-242m will be evaluated, and Np-237, Am-241, Am-243, Cm-243, Cm-244 will be tested and improved. Full file of Bi was prepared. Full files for Pb isotopes are in process of preparation. There exist a plan to analyze full files for isotopes of Cr, Fe, Ni from existing evaluated data libraries, to select more reliable cross sections, and to create improved files for these isotopes. Together with the Theoretical Department the work is in progress on the determination of uncertainties of existing evaluated data and development of covariance matrices for some important

  10. Tumor heterogeneity and progression: conceptual foundations for modeling.

    Science.gov (United States)

    Greller, L D; Tobin, F L; Poste, G

    1996-01-01

    A conceptual foundation for modeling tumor progression, growth, and heterogeneity is presented. The purpose of such models is to aid understanding, test ideas, formulate experiments, and to model cancer 'in machina' to address the dynamic features of tumor cell heterogeneity, progression, and growth. The descriptive capabilities of such an approach provides a consistent language for qualitatively reasoning about tumor behavior. This approach provides a schema for building conceptual models that combine three key phenomenological driving elements: growth, progression, and genetic instability. The growth element encompasses processes contributing to changes in tumor bulk and is distinct from progression per se. The progression element subsumes a broad collection of processes underlying phenotypic progression. The genetics elements represents heritable changes which potentially affect tumor character and behavior. Models, conceptual and mathematical, can be built for different tumor situations by drawing upon the interaction of these three distinct driving elements. These models can be used as tools to explore a diversity of hypotheses concerning dynamic changes in cellular populations during tumor progression, including the generation of intratumor heterogeneity. Such models can also serve to guide experimentation and to gain insight into dynamic aspects of complex tumor behavior.

  11. Progress and controversies in developing cancer vaccines

    Directory of Open Access Journals (Sweden)

    Speiser Daniel E

    2005-04-01

    Full Text Available Abstract Immunotherapy has become a standard approach for cancer management, through the use of cytokines (eg: interleukin-2 and monoclonal antibodies. Cancer vaccines hold promise as another form of immunotherapy, and there has been substantial progress in identifying shared antigens recognized by T cells, in developing vaccine approaches that induce antigen-specific T cell responses in cancer patients, and in developing new technology for monitoring immune responses in various human tissue compartments. Dramatic clinical regressions of human solid tumors have occurred with some cancer vaccines, but the rate of those responses remains low. This article is part of a 2-part point:counterpoint series on peptide vaccines and adoptive therapy approaches for cancer. The current status of cancer vaccination, and associated challenges, are discussed. Emphasis is placed on the need to increase our knowledge of cancer immunobiology, as well as to improve monitoring of cellular immune function after vaccination. Progress in both areas will facilitate development of effective cancer vaccines, as well as of adoptive therapy. Effective cancer vaccines promise to be useful for treatment and prevention of cancer at low cost and with low morbidity.

  12. CBM progress report 2007

    Energy Technology Data Exchange (ETDEWEB)

    Herrmann, N.; Rami, F.; Roehrich, D.; Stroth, J.; Wessels, J.; Zaitsev, Yu

    2008-02-15

    This report documents the activities within the CBM project in 2007. Significant progress has been made in the optimization of the simulation software, the layout and development of detectors, the design of front-end electronics, and the concepts for data acquisition. The simulation and analysis routines have been completely integrated into the software framework (FAIRoot and CBMroot), and can be used now easily by users outside GSI. A breakthrough has been achieved in the development of fast algorithms for track and vertex reconstruction which have been improved in speed by a factor of 10{sup 5}. These fast routines permit to perform high-statistics simulations for detailed detector layout optimization. Full event reconstruction based on realistic detector properties and particle multiplicities as given by microscopic transport models are routinely used in the feasibility studies. A version of the Silicon Tracking System is now implemented in the simulation software comprising 8 detector layers based on microstrip technology only, including the readout cables, and the mechanical detector structure. The studies of open charm detection have been extended to D{sub s}{sup +} and {lambda}{sub c}, taking into account a realistic layout of the Silicon Pixel Microvertex detector. The identification of electrons has been optimized by improved ring recognition algorithms and transition radiation simulations. The Ring Imaging Cherenkov (RICH) detector has been redesigned, resulting in a reduction by a factor of two in mirror size and number of readout channels without reducing the pion rejection capability. The muon detection system has been optimized with respect to the number of detector layers. The muon simulations take into account detector inefficiencies and a segmentation of the muon chambers into pads according to a nominal occupancy of 5% for central Au+Au collisions. Studies for a dimuon trigger show promising results. Radiation dose simulations using the FLUKA

  13. CBM progress report 2007

    International Nuclear Information System (INIS)

    Herrmann, N.; Rami, F.; Roehrich, D.; Stroth, J.; Wessels, J.; Zaitsev, Yu

    2008-02-01

    This report documents the activities within the CBM project in 2007. Significant progress has been made in the optimization of the simulation software, the layout and development of detectors, the design of front-end electronics, and the concepts for data acquisition. The simulation and analysis routines have been completely integrated into the software framework (FAIRoot and CBMroot), and can be used now easily by users outside GSI. A breakthrough has been achieved in the development of fast algorithms for track and vertex reconstruction which have been improved in speed by a factor of 10 5 . These fast routines permit to perform high-statistics simulations for detailed detector layout optimization. Full event reconstruction based on realistic detector properties and particle multiplicities as given by microscopic transport models are routinely used in the feasibility studies. A version of the Silicon Tracking System is now implemented in the simulation software comprising 8 detector layers based on microstrip technology only, including the readout cables, and the mechanical detector structure. The studies of open charm detection have been extended to D s + and Λ c , taking into account a realistic layout of the Silicon Pixel Microvertex detector. The identification of electrons has been optimized by improved ring recognition algorithms and transition radiation simulations. The Ring Imaging Cherenkov (RICH) detector has been redesigned, resulting in a reduction by a factor of two in mirror size and number of readout channels without reducing the pion rejection capability. The muon detection system has been optimized with respect to the number of detector layers. The muon simulations take into account detector inefficiencies and a segmentation of the muon chambers into pads according to a nominal occupancy of 5% for central Au+Au collisions. Studies for a dimuon trigger show promising results. Radiation dose simulations using the FLUKA transport code have been

  14. Progress in surface and membrane science

    CERN Document Server

    Cadenhead, D A

    1979-01-01

    Progress in Surface and Membrane Science, Volume 12 covers the advances in the study of surface and membrane science. The book discusses the topographical differentiation of the cell surface; the NMR studies of model biological membrane system; and an irreversible thermodynamic approach to energy coupling in mitochondria and chloroplasts. The text also describes water at surfaces; the nature of microemulsions; and the energy principle in the stability of interfaces. Biochemists, physicists, chemical engineers, and people involved in surface and coatings research will find the book invaluable.

  15. Progress in MMIC technology for satellite communications

    Science.gov (United States)

    Haugland, Edward J.; Leonard, Regis F.

    1987-01-01

    NASA's Lewis Research Center is actively involved in the development of monolithic microwave and millimeter-wave integrated circuits (MMICs). The approach of the program is to support basic research under grant or in-house, while MMIC development is done under contract, thereby facilitating the transfer of technology to users. Preliminary thrusts of the program have been the extension of technology to higher frequencies (60 GHz), degrees of complexity, and performance (power, efficiency, noise figure) by utilizing novel circuit designs, processes, and materials. A review of the progress made so far is presented.

  16. Adaptive measurement selection for progressive damage estimation

    Science.gov (United States)

    Zhou, Wenfan; Kovvali, Narayan; Papandreou-Suppappola, Antonia; Chattopadhyay, Aditi; Peralta, Pedro

    2011-04-01

    Noise and interference in sensor measurements degrade the quality of data and have a negative impact on the performance of structural damage diagnosis systems. In this paper, a novel adaptive measurement screening approach is presented to automatically select the most informative measurements and use them intelligently for structural damage estimation. The method is implemented efficiently in a sequential Monte Carlo (SMC) setting using particle filtering. The noise suppression and improved damage estimation capability of the proposed method is demonstrated by an application to the problem of estimating progressive fatigue damage in an aluminum compact-tension (CT) sample using noisy PZT sensor measurements.

  17. Metaheuristics progress as real problem solvers

    CERN Document Server

    Nonobe, Koji; Yagiura, Mutsunori

    2005-01-01

    Metaheuristics: Progress as Real Problem Solvers is a peer-reviewed volume of eighteen current, cutting-edge papers by leading researchers in the field. Included are an invited paper by F. Glover and G. Kochenberger, which discusses the concept of Metaheuristic agent processes, and a tutorial paper by M.G.C. Resende and C.C. Ribeiro discussing GRASP with path-relinking. Other papers discuss problem-solving approaches to timetabling, automated planograms, elevators, space allocation, shift design, cutting stock, flexible shop scheduling, colorectal cancer and cartography. A final group of methodology papers clarify various aspects of Metaheuristics from the computational view point.

  18. Health: An Ecosystem Approach

    International Development Research Centre (IDRC) Digital Library (Canada)

    In the early days, the research supported was largely biomedical: vaccines, ... editor of Découvrir magazine in Montréal, who produced the first draft of the book, ...... Their transdisciplinary approach included gender-specific parameters. ..... Over time, some progress was made against malaria, but the war was far from won.

  19. Diagnosis in progressive hirsutism

    Energy Technology Data Exchange (ETDEWEB)

    Soerensen, R.; Moltz, L.

    1981-09-01

    Catheterization of adrenal and ovarian veins in combination with hormone concentration analyses was performed in seventy hirsute women. There was suspicion of tumor in 30 cases because of excess androgen production (plasma testosterone more than 1.5 ng/ml and/or plasma dehydroepiandrosterone sulfate more than 7000 ng/ml in peripheral blood samplings). Catheterization and blood sampling was done with a femoro-visceral catheter by the transfemoral approach. Contributary blood flows from many different venous systems were found to be more often to the right ovarian and to the left adrenal veins in comparison to the other side. Catheterization of the wrong vessels occurred without being recognized immediately (circumaortic renal collar, inferior phrenic vein, ascending lumbar vein). These pitfalls might falsify blood samplings. There were no significant complications. Seven ovarian tumors were localized. Their size ranged from 0.5 to 2.5 cm in diameter. They were not recognized during laparoscopy. There were 10 hyperthecoses, four adrenogenital syndromes, one abortive testis, one adrenal adenoma, one Cushing's syndrome and one Cushing's disease due to an adenoma of the picture gland. In five patients a diagnosis could not be made. Tumor was excluded in forty patients. Their virilization was of adrenal origin in 32%, of ovarian origin in 29%, and of both adrenal and ovarian origin in 22%. In 17% a source of the excess androgen production was not found. This differential diagnosis is not important for the patient therapy.

  20. Psychological functioning in primary progressive versus secondary progressive multiple sclerosis

    DEFF Research Database (Denmark)

    Vleugels, L; Pfennings, L E; Pouwer, F

    1998-01-01

    Psychological functioning in two types of multiple sclerosis (MS) patients is assessed: primary progressive (PP) and secondary progressive (SP) patients. On the basis of differences in clinical course and underlying pathology we hypothesized that primary progressive patients and secondary...... progressive patients might have different psychological functioning. Seventy patients treated in an MS centre were examined cross-sectionally. Forty had an SP course of MS and 30 a PP course. The 33 male and 37 female patients had a mean age of 48.4 years (SD 11.2) and mean age of onset of MS of 30.7 years...... (SD 11.1). Patients completed questionnaires measuring among others the following aspects of psychological functioning: depression (BDI, SCL-90), anxiety (STAI, SCL-90), agoraphobia (SCL-90), somatic complaints (SCL-90), hostility (SCL-90) and attitude towards handicap (GHAS). Patients with a PP...

  1. Visualising Chord Progressions in Music Collections: A Big Data Approach

    OpenAIRE

    Kachkaev, A.; Wolff, D.; Barthet, M.; Tidhar, D.; Plumbley, M. D.; Dykes, J.; Weyde, T.

    2014-01-01

    In the Digital Music Lab project we work on the automatic analysis of large audio databases that results in rich annotations for large corpora of music. The musicological interpretation of this data from thousands of pieces is a challenging task that can benefit greatly from specifically designed interactive visualisation. Most existing big music data visualisation focuses on cultural attributes, mood, or listener behaviour.\\ud \\ud In this ongoing work we explore chord sequence patterns extract...

  2. Creating a Strategy for Progress: A Contextual Behavioral Science Approach

    Science.gov (United States)

    Vilardaga, Roger; Hayes, Steven C.; Levin, Michael E.; Muto, Takashi

    2009-01-01

    Behavior analysis is a field dedicated to the development and application of behavioral principles to the understanding and modification of the psychological actions of organisms. As such, behavior analysis was committed from the beginning to a comprehensive account of behavior, stretching from animal learning to complex human behavior. Despite…

  3. A Progressive Approach to Teaching Analytics in the Marketing Curriculum

    Science.gov (United States)

    Liu, Yiyuan; Levin, Michael A.

    2018-01-01

    With the emerging use of analytics tools and methodologies in marketing, marketing educators have provided students training and experiences beyond the soft skills associated with understanding consumer behavior. Previous studies have only discussed how to apply analytics in course designs, tools, and related practices. However, there is a lack of…

  4. A Molecular Approach for Metatastic Progression of Breast Cancer

    National Research Council Canada - National Science Library

    Vadlamudi, Ratna

    2003-01-01

    .... HER2/HRG signaling selectively upregulated Tyr phosphorylation of c-Src at Tyr-2l5 located with in the SH2 domain, increased c-Src kinase activity and selectively upregulated Tyr phosphorylation of FAK at Tyr-86l...

  5. Federal Facility Agreement progress report

    Energy Technology Data Exchange (ETDEWEB)

    1993-10-01

    The (SRS) Federal Facility Agreement (FFA) was made effective by the US. Environmental Protection Agency Region IV (EPA) on August 16, 1993. To meet the reporting requirements in Section XXV of the Agreement, the FFA Progress Report was developed. The FFA Progress Report is the first of a series of quarterly progress reports to be prepared by the SRS. As such this report describes the information and action taken to September 30, 1993 on the SRS units identified for investigation and remediation in the Agreement. This includes; rubble pits, runoff basins, retention basin, seepage basin, burning pits, H-Area Tank 16, and spill areas.

  6. Federal Facility Agreement progress report

    International Nuclear Information System (INIS)

    1993-10-01

    The (SRS) Federal Facility Agreement (FFA) was made effective by the US. Environmental Protection Agency Region IV (EPA) on August 16, 1993. To meet the reporting requirements in Section XXV of the Agreement, the FFA Progress Report was developed. The FFA Progress Report is the first of a series of quarterly progress reports to be prepared by the SRS. As such this report describes the information and action taken to September 30, 1993 on the SRS units identified for investigation and remediation in the Agreement. This includes; rubble pits, runoff basins, retention basin, seepage basin, burning pits, H-Area Tank 16, and spill areas

  7. Early detection of emphysema progression

    DEFF Research Database (Denmark)

    Gorbunova, Vladlena; Jacobs, Sander S A M; Lo, Pechin

    2010-01-01

    Emphysema is one of the most widespread diseases in subjects with smoking history. The gold standard method for estimating the severity of emphysema is a lung function test, such as forced expiratory volume in first second (FEV1). However, several clinical studies showed that chest CT scans offer...... more sensitive estimates of emphysema progression. The standard CT densitometric score of emphysema is the relative area of voxels below a threshold (RA). The RA score is a global measurement and reflects the overall emphysema progression. In this work, we propose a framework for estimation of local...... emphysema progression from longitudinal chest CT scans. First, images are registered to a common system of coordinates and then local image dissimilarities are computed in corresponding anatomical locations. Finally, the obtained dissimilarity representation is converted into a single emphysema progression...

  8. Zolpidem in Progressive Supranuclear Palsy

    Directory of Open Access Journals (Sweden)

    Sandip K. Dash

    2013-01-01

    Full Text Available Progressive supranuclear palsy (PSP is a progressive neurodegenerative disorder, characterized by motor symptoms, postural instability, personality changes, and cognitive impairment. There is no effective treatment for this disorder. Reduced neurotransmission of GABA in the striatum and globus pallidus may contribute to the symptoms of motor and cognitive symptoms seen in PSP. Zolpidem is a GABA agonist of the benzodiazepine subreceptor BZ1. Here a nondiabetic, normotensive case of PSP is (Progressive Supranuclear Palsy described, which showed improvement in swallowing, speech, and gaze paresis after zolpidem therapy and possible mechanism of actions are discussed. However, more trials are needed with large number of patients to confirm the effectiveness of zolpidem in progressive supranuclear palsy.

  9. Progresses in proton radioactivity studies

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, L. S., E-mail: flidia@ist.utl.pt [Center of Physics and Engineering of Advanced Materials, CeFEMA and Departamento de Física, Instituto Superior Técnico, Universidade de Lisboa, Avenida Rovisco Pais, P1049-001 Lisbon (Portugal); Maglione, E. [Dipartimento di Fisica e Astronomia “G. Galilei”, Via Marzolo 8, I-35131 Padova, Italy and Istituto Nazionale di Fisica Nucleare, Padova (Italy)

    2016-07-07

    In the present talk, we will discuss recent progresses in the theoretical study of proton radioactivity and their impact on the present understanding of nuclear structure at the extremes of proton stability.

  10. Nitrate | Cancer Trends Progress Report

    Science.gov (United States)

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

  11. Sunburn | Cancer Trends Progress Report

    Science.gov (United States)

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

  12. Preventing Breast Cancer: Making Progress

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues Preventing Breast Cancer: Making Progress Past Issues / Fall 2006 Table of ... 000 women will have been diagnosed with invasive breast cancer, and nearly 41,000 women will die from ...

  13. Defining active progressive multiple sclerosis

    DEFF Research Database (Denmark)

    Sellebjerg, Finn; Börnsen, Lars; Ammitzbøll, Cecilie

    2017-01-01

    BACKGROUND: It is unknown whether disease activity according to consensus criteria (magnetic resonance imaging activity or clinical relapses) associate with cerebrospinal fluid (CSF) changes in progressive multiple sclerosis (MS). OBJECTIVE: To compare CSF biomarkers in active and inactive...

  14. Progressive Salafism in Online Fatwa

    Directory of Open Access Journals (Sweden)

    R. Rusli

    2015-04-01

    Full Text Available This paper deals with the construction of progressive Salafism in online fatwa, particularly in the site of Islam Online. This website is established by Yūsuf al-Qarāḍāwī and his colleagues within the European Council for Fatwa and Research, which has been influenced by reformist-salafists, such as al-Shawkānī, al-Afghānī, ‘Abduh, and Riḍā, who underline the role of text and modernity. The site’s approach is progressive-substantialist (combining teks and reality, which is built on the principles of Islamic law on minorities (fiqh al-aqalliyyāt, like taysīr (facilitation, wasaṭiyyah (moderation, and i’tidāl (equilibrium, that are seen as universal values contributing to the creation of a global-pluralist society. Because of its moderate nature, the language used by the site tends to emphasize not on prohibiting and labelling “heretic”, but on a solution to the problems people encounter. In relation to socio-political language, the concept of ummah is understood in an inclusive way. Ummah is built and based on the principles of belief (īmān and Islam, and tied by the solidarity of the Quranic messages about Islamic monotheism (tawḥīd and divine justice (‘adl. The concept of ummah refers to the Quranic concepts such as ummah wasaṭ or ummah muqtaṣidah, which means “moderate community”.[Artikel ini membahas tentang konstruksi Salafisme progresif dalam fatwa online, terutama situs Islam Online. Website ini didorong oleh Yūsuf al-Qarāḍāwī dan para koleganya dalam European Council for Fatwa and Research, yang dipengaruhi oleh salafi-reformis, seperti al-Shawkānī, al-Afghānī, ‘Abduh, dan Riḍā, yang menghargai teks dan modernitas. Pendekatan situs ini adalah progresif-substansialis (menggabungkan teks dan realitas, yang dibangun pada prinsip-prinsip fikih minoritas (fiqh al-aqalliyyāt, seperti taysīr (memberikan kemudahan, wasaṭiyyah (moderat, dan i’tidāl (keseimbangan,yang dilihat sebagai

  15. Annual Progress report - General Task

    International Nuclear Information System (INIS)

    Wesnousky, S.G.

    1993-01-01

    This report provides a summary of progress for the project open-quotes Evaluation of the Geologic Relations and Seismotectonic Stability of the Yucca Mountain Area, Nevada Nuclear Waste Site Investigation (NNWSI).close quotes A similar report was previously provided for the period of 1 October 1991 to 30 September 1992. The report initially covers the activities of the General Task and is followed by sections that describe the progress of the other ongoing tasks

  16. Progressive technologies in furniture design

    OpenAIRE

    Šebková, Martina

    2014-01-01

    Šebková, M. Progressive technologies in furniture design. Diploma thesis, Brno, Mendel University in Brno, 2014 Diploma thesis 'Progressive technologies in furniture design' is focused on the use of modern technologies in furniture production. The theoretical part explains the basic terms, technology and material options. It focuses mainly on the production of 3D printed furniture and possibilities of virtual testing, measurements, scanning and rapid prototyping. Practical part of diploma the...

  17. Targeting ECM Disrupts Cancer Progression

    DEFF Research Database (Denmark)

    Venning, Freja A; Wullkopf, Lena; Erler, Janine T

    2015-01-01

    , the extracellular matrix (ECM). Many ECM proteins are significantly deregulated during the progression of cancer, causing both biochemical and biomechanical changes that together promote the metastatic cascade. In this review, the influence of several ECM proteins on these multiple steps of cancer spread...... is summarized. In addition, we highlight the promising (pre-)clinical data showing benefits of targeting these ECM macromolecules to prevent cancer progression....

  18. Progression of chronic renal failure.

    Science.gov (United States)

    Hakim, R M; Lazarus, J M

    1989-11-01

    Rates of progression of renal failure were calculated for a group of 277 patients who had five or more clinic visits. The goals of therapy in the absence of ongoing immunological processes were control of blood pressure to diastolic pressures less than 85 mm Hg and serum phosphate less than 1.60 mmol/L (5 mg/dL). The mean rate of progression expressed as the slope of the reciprocal creatinine versus time was -0.0054 +/- 0.0009 dL/mg/mo (mean +/- SEM), and the median was -0.00315 dL/mg/mo. Approximately 25% of these patients had rates of progression less than -0.001 dL/mg/mo. The rate of progression was inversely correlated with the creatinine concentration at entry (P less than 0.004) and with the frequency of clinic visits (P less than 0.01). The "renal survival" time from a creatinine of 880 mumol/L (10 mg/dL) to dialysis was 10.0 +/- 1.2 months (mean +/- SEM). These data provide rates of progression for a group of patients without specific dietary intervention but with vigorous control of blood pressure and phosphorus.

  19. The first year: A cultural shift towards improving student progress

    Directory of Open Access Journals (Sweden)

    Becky Jobe

    2016-03-01

    Full Text Available Student attrition has been a primary focus among higher education institutions for nearly 50 years, yet overall retention and graduation rates continue to be of significant concern. Despite increased attention, ongoing struggles of colleges and universities to effectively address potential barriers to student progress are well-documented.  Part of the challenge lies in garnering widespread organizational commitment that establishes student progress as an institutional priority.  Along with leadership commitment, broad institutional involvement and adherence to a systematic approach to testing new, innovative solutions are necessary to better position the institution to make clear, evidence-based decisions that improve the student experience. The purpose of this manuscript is to detail one university’s cultural shift towards establishing a clear student progress strategy (with particular focus on the first year, and the methodological approach that laid the foundation for a multi-year study of initiatives that resulted in improved student satisfaction, performance, and retention.

  20. Applied Behavior Analysis Is a Science And, Therefore, Progressive

    Science.gov (United States)

    Leaf, Justin B.; Leaf, Ronald; McEachin, John; Taubman, Mitchell; Ala'i-Rosales, Shahla; Ross, Robert K.; Smith, Tristram; Weiss, Mary Jane

    2016-01-01

    Applied behavior analysis (ABA) is a science and, therefore, involves progressive approaches and outcomes. In this commentary we argue that the spirit and the method of science should be maintained in order to avoid reductionist procedures, stifled innovation, and rote, unresponsive protocols that become increasingly removed from meaningful…

  1. Recent progress in ecological studies of soil fauna

    NARCIS (Netherlands)

    Hasegawa, Motohiro; Fujii, Saori; Kaneda, Satoshi; Ikeda, Hiroshi; Hishi, Takuo; Hyodo, Fujio; Kobayashi, Makoto

    2017-01-01

    Progress in ecological studies of soil fauna includes studies of the role and effects of soil fauna on decomposition and soil carbon dynamics in relation to global environmental changes, the introduction of molecular biology approaches to such studies, feeding habit analysis using stable isotopes,

  2. Recent achievements in restorative neurology: Progressive neuromuscular diseases

    International Nuclear Information System (INIS)

    Dimitrijevic, M.R.; Kakulas, B.A.; Vrbova, G.

    1986-01-01

    This book contains 27 chapters. Some of the chapter titles are: Computed Tomography of Muscles in Neuromuscular Disease; Mapping the Genes for Muscular Dystrophy; Trophic Factors and Motor Neuron Development; Size of Motor Units and Firing Rate in Muscular Dystrophy; Restorative Possibilities in Relation to the Pathology of Progressive Neuromuscular Disease; and An Approach to the Pathogenesis of some Congenital Myopathies

  3. Engineering of obligate intracellular bacteria: progress, challenges and paradigms

    Science.gov (United States)

    Over twenty years have passed since the first report of genetic manipulation of an obligate intracellular bacterium. Through progress interspersed by bouts of stagnation, microbiologists and geneticists have developed approaches to genetically manipulate obligates. A brief overview of the current ge...

  4. Students' Progress throughout Examination Process as a Markov Chain

    Science.gov (United States)

    Hlavatý, Robert; Dömeová, Ludmila

    2014-01-01

    The paper is focused on students of Mathematical methods in economics at the Czech university of life sciences (CULS) in Prague. The idea is to create a model of students' progress throughout the whole course using the Markov chain approach. Each student has to go through various stages of the course requirements where his success depends on the…

  5. Tracking Clean Energy Progress 2013

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-06-01

    Tracking Clean Energy Progress 2013 (TCEP 2013) examines progress in the development and deployment of key clean energy technologies. Each technology and sector is tracked against interim 2020 targets in the IEA Energy Technology Perspectives 2012 2°C scenario, which lays out pathways to a sustainable energy system in 2050. Stark message emerge: progress has not been fast enough; large market failures are preventing clean energy solutions from being taken up; considerable energy efficiency remains untapped; policies need to better address the energy system as a whole; and energy-related research, development and demonstration need to accelerate. Alongside these grim conclusions there is positive news. In 2012, hybrid-electric vehicle sales passed the 1 million mark. Solar photovoltaic systems were being installed at a record pace. The costs of most clean energy technologies fell more rapidly than anticipated.

  6. Building a progressive vertical integration

    International Nuclear Information System (INIS)

    Charette, D.

    2008-01-01

    AAER Inc. is a Quebec-based company that manufactures turbines using proven European designs. This presentation discussed the company's business model. The company places an emphasis on identifying strategic and key components currently available for its turbines. Market analyses are performed in order to determine ideal suppliers and define business strategies and needs. The company invests in long-term relationships with its suppliers. Business partners for AAER are of a similar size and have a mutual understanding and respect for the company's business practices. Long-term agreements with suppliers are signed in order to ensure reliability and control over costs. Progressive vertical integration has been achieved by progressively manufacturing key components and integrating a North American supply chain. The company's secure supply chain and progressive vertical integration has significantly reduced financial costs and provided better quality control. It was concluded that vertical integration has also allowed AAER to provide better customer service and reduce transportation costs. tabs., figs

  7. Rapidly Progressive Quadriplegia and Encephalopathy.

    Science.gov (United States)

    Wynn, DonRaphael; McCorquodale, Donald; Peters, Angela; Juster-Switlyk, Kelsey; Smith, Gordon; Ansari, Safdar

    2016-11-01

    A woman aged 77 years was transferred to our neurocritical care unit for evaluation and treatment of rapidly progressive motor weakness and encephalopathy. Examination revealed an ability to follow simple commands only and abnormal movements, including myoclonus, tongue and orofacial dyskinesias, and opsoclonus. Imaging study findings were initially unremarkable, but when repeated, they demonstrated enhancement of the cauda equina nerve roots, trigeminal nerve, and pachymeninges. Cerebrospinal fluid examination revealed mildly elevated white blood cell count and protein levels. Serial electrodiagnostic testing demonstrated a rapidly progressive diffuse sensory motor axonopathy, and electroencephalogram findings progressed from generalized slowing to bilateral periodic lateralized epileptiform discharges. Critical details of her recent history prompted a diagnostic biopsy. Over time, the patient became completely unresponsive with no further abnormal movements and ultimately died. The differential diagnosis, pathological findings, and diagnosis are discussed with a brief review of a well-known yet rare diagnosis.

  8. World progress toward fusion energy

    International Nuclear Information System (INIS)

    Davies, N.A.

    1989-01-01

    The author discusses international progress in fusion research during the last three years. Much of the technical progress has been achieved through international collaboration in magnetic fusion research. This progress has stimulated political interest in a multinational effort, aimed at designing and possibly constructing the world's first experimental fusion reactor. This interest was reflected in recent summit-level discussions involving President Mitterand, General Secretary Gorbachev, and President Reagan. Most recently, the European Community (EC), Japan, the United States, and the U.S.S.R. have decided to begin serious preparation for taking the next step toward practical fusion energy. These parties have agreed to begin the design and supporting R and D for an International Thermonuclear Experimental Reactor (ITER) under the auspices of the International Atomic Energy Agency (IAEA). The initiation of this international program to prepare for a fusion test reactor is discussed

  9. Progressively safer, cheaper demolition of Fernald

    International Nuclear Information System (INIS)

    Nichols, Robert; Pennington, Norman

    2000-01-01

    Fluor Fernald, Inc. has been progressively improving Decontamination and Dismantlement (D and D) at the Department of Energy's Fernald Environmental Management Project by applying new technologies and better methodologies to the work. Demolition issues existed in the past that necessitated new or improved solutions to maintain worker safety, protect the environment and accomplish the work in a cost effective manner. Lessons learned from D and D of 80 structures has led to a systematic approach, which can be implemented in various D and D arenas. When facility production was halted, hold-up material and process residues remained in the process piping and components. Over 500,000 pounds of material was removed by workers who completed the tasks two years ahead of schedule, $7 million under budget and with an excellent safety record. This success was the result of detailed planning and irdision of lessons learned as work progressed from facility to facility. Work sequences were developed that reduced airborne contamination. Demolition of structures has been performed at Fernald by carefully selected and qualified subcontractors. Asbestos and lead abatement, equipment, piping and conduit removal, and structural demolition have been completed to progressively higher performance specifications developed by Fluor Fernald based on lessons learned during execution. Safety continues to be the primary consideration in performing potentially hazardous work. Technologies such as hydraulic shears have been developed and used to keep workers away from danger. A new technology, ''Cool Suits,'' has been demonstrated to help prevent heat stress when anti-contamination clothing is required in elevated temperature working conditions. For tall structures, implosion technologies have been employed with progressively improved results, Several other new technologies have been evaluated by Fluor Fernald and applied by subcontractors. The improved technologies included the oxy-gas torch

  10. Biogas Opportunities Roadmap Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2015-12-01

    In support of the Obama Administration's Climate Action Plan, the U.S. Department of Energy, the U.S. Environmental Protection Agency, and U.S. Department of Agriculture jointly released the Biogas Opportunities Roadmap Progress Report, updating the federal government's progress to reduce methane emissions through biogas systems since the Biogas Opportunities Roadmap was completed by the three agencies in July 2014. The report highlights actions taken, outlines challenges and opportunities, and identifies next steps to the growth of a robust biogas industry.

  11. Communication of nuclear data progress

    International Nuclear Information System (INIS)

    2001-01-01

    This is the 26th issue of Communication of Nuclear Data Progress (CNDP), in which the progress and achievements in nuclear data field from the last year up to now in China are carried. It includes the measurements of 71 Ga, 94 Zn, 191 Ir, 174 Hf(n, γ) and 114 Cd(n, 2n) cross sections, fission product yields of n + 235,238 U, DPA cross section calculated with UNF code, fission barrier parameter evaluation of some nuclides, production and transmission of covariance in the evaluation processing of fission yield data and transition analysis of Ne-like Ge XXIII

  12. Progressive multiple sclerosis: from pathogenic mechanisms to treatment.

    Science.gov (United States)

    Correale, Jorge; Gaitán, María I; Ysrraelit, María C; Fiol, Marcela P

    2017-03-01

    in progressive multiple sclerosis, correlations between histopathology and magnetic resonance imaging studies, along with possible new therapeutic approaches. © The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  13. Progressive macular hypomelanosis: an overview

    NARCIS (Netherlands)

    Relyveld, Germaine N.; Menke, Henk E.; Westerhof, Wiete

    2007-01-01

    Progressive macular hypomelanosis (PMH) is a common skin disorder that is often misdiagnosed. Various authors have written about similar skin disorders, referring to them by different names, but we believe that all these similar disorders are part of the same entity.PMH is characterized by

  14. Progress Report 1985-1986

    International Nuclear Information System (INIS)

    1987-01-01

    The research directions in the Physics Institute of Universidade Federal do Rio Grande do Sul are presented. The progress reports cavied out in the follow areas are presented: perturbed angular correlation; Moessbauer spectroscopy; ion implantation; magnetism and electronic transport; microelectronics; condensed matter theory; quantum field theory; plasma physics; nuclear physics; astronomy and astrophysics; and instrumentation. (M.C.K.) [pt

  15. Technological Progress, Exit and Trade

    DEFF Research Database (Denmark)

    Schröder, Philipp; Sørensen, Allan

    productivity exporters are more likely to continue to export, and market exit is typically preceded by periods of contracting market shares. We show that the simple inclusion of exogenous economy wide technological progress into the standard Melitz (2003) model generates a tractable dynamic framework...

  16. Progress in color night vision

    NARCIS (Netherlands)

    Toet, A.; Hogervorst, M.A.

    2012-01-01

    We present an overview of our recent progress and the current state-of-the-art techniques of color image fusion for night vision applications. Inspired by previously developed color opponent fusing schemes, we initially developed a simple pixel-based false color-mapping scheme that yielded fused

  17. Recent progress in sodium technology

    Energy Technology Data Exchange (ETDEWEB)

    Hallett, W. J.

    1963-10-15

    Progress over the past year in U. S. laboratories studying some of the materials and engineering problems that must be resolved in bringing the technology of sodium to an economically and technically attractive point is reviewed. The status of sodium cooled power reactors in the U. S. is described. (P.C.H.)

  18. Progress report 1971/72

    International Nuclear Information System (INIS)

    1972-01-01

    The progress report comprises reports from interdisciplinary task groups on radiation protection, isotope application and radiation measurement technique, microscopy, linear accelerators, process computers, biophysics and nuclear physics. The last task group reports on work with the electron linear accelerator, nuclear spectroscopy, neutron physics, work with polarized particles, and experiments with the GSI heavy ion accelerator. (orig./AK) [de

  19. Popular support for progressive taxation

    OpenAIRE

    Marhuenda Hurtado, Francisco; Ortuño Ortín, Ignacio Isidro

    1995-01-01

    The popular support obtained by two parties who propose two qualitatively different tax schernes is analyzed. We show that if the median voter is below the mean, then any progressive proposal always wins over a regressive one, provided it leaves the poorest agent at least as well off as the latter does.

  20. Progress at the Shanghai EBIT

    International Nuclear Information System (INIS)

    He Mianhong; Liu Yong; Yang Yang; Wu Shimin; Chen Weidong; Hu Wei; Guo, Panlin; Lu Di; Fu Yunqing; Huang Min; Zhang Xuemei; Hutton, Roger; Liljeby, Leif; Zou Yaming

    2007-01-01

    In this report, a brief description of the progress of the Shanghai EBIT project is presented. This is followed by short discussions on the X ray spectra at several electron beam energies and the ion densities in the EBIT at a specific running condition

  1. Progress in semiconductor drift detectors

    International Nuclear Information System (INIS)

    Rehak, P.; Walton, J.; Gatti, E.

    1985-01-01

    Progress in testing semiconductor drift detectors is reported. Generally better position and energy resolutions were obtained than resolutions published previously. The improvement is mostly due to new electronics better matched to different detectors. It is shown that semiconductor drift detectors are becoming versatile and reliable detectors for position and energy measurements

  2. Annual progress report FY 1977

    International Nuclear Information System (INIS)

    Hansen, K.F.; Henry, A.F.

    1977-07-01

    Progress is summarized in a project directed toward development of numerical methods suitable for the computer solution of problems in reactor dynamics and safety. Specific areas of research include methods of integration of the time-dependent diffusion equations by finite difference and finite element methods; representation of reactor properties by various homogenization procedures; application of synthesis methods; and development of response matrix techniques

  3. Minority Student Progress Report, 1991.

    Science.gov (United States)

    Diaz, Porfirio R.; Luan, Jing

    This report offers a consolidated systemwide analysis of key issues and recommendations for improvement of minority recruitment and retention at Arizona State Universities and an evaluation of progress toward achieving Arizona Board of Regents (ABOR) approved recruitment and graduation goals. A description of ABOR system goals notes three goals:…

  4. Nuclear Physics Division progress report

    International Nuclear Information System (INIS)

    West, D.; Cookson, J.A.; Findlay, D.J.S.

    1984-06-01

    The 1983 progress report of the Nuclear Physics Division, UKAEA Harwell, is divided into four main topics. These are a) nuclear data and technology for nuclear power; b) nuclear studies; c) applications of nuclear and associated techniques, including ion beam techniques and moessbauer spectroscopy; and d) accelerator operation, maintenance and development. (U.K.)

  5. Ultrasonic flowmeters. Progress report II

    International Nuclear Information System (INIS)

    Wittekind, W.D.

    1980-01-01

    This progress report presents results of in-plant testing of the prototype ultrasonic flowmeter and describes modifications to the prototype as a result of these tests. The modified prototype, designated MOD-I, is described in detail including the principle of operation, equipment used and the results of both laboratory and in-plant demonstrations

  6. Progress: Its Glories and Pitfalls.

    Science.gov (United States)

    Callahan, Daniel

    2018-03-01

    Steven Pinker, a cognitive psychologist and linguist at Harvard and a savant of big ideas, is one of the latest to take on the idea of progress. He does it under the aegis of "enlightenment," which comes down to a kind of holy trinity of reason, science, and humanism. His new book, Enlightenment Now: The Case for Reason, Science, Humanism, and Progress, is ambitious and cantankerous and heady with hope. On the whole, Pinker makes a good case for the benefits of progress, but with an overdose of feel-good prose. His greatest failure comes in exaggerating the threats to science and in avoiding some problems altogether. He ignores its complexity, its shadows, its creation of new problems raised by its solutions to old ones. Pinker has a particular animus against bioethics, and he misses what has been, I would argue, at the heart of bioethics from its beginning fifty or so years ago. Bioethics was prompted by a new class of medical dilemmas that require a difficult balancing of harms and benefits. Most of them are still with us, and most of them are the result of the progress of postwar medical research and fast-changing clinical practices. © 2018 The Hastings Center.

  7. FMIT Test assemblies. Progress report

    International Nuclear Information System (INIS)

    Nygren, R.E.; Opperman, E.K.

    1978-08-01

    This progress report is a reference document for a number of inter-related tasks supporting the Fusion Materials Irradiation Test (FMIT) Facility being developed by the Hanford Engineering Development Laboratory. The report describes the basic configuration of test assemblies and supporting rationale based on the neutron flux distribution. Perturbed and unperturbed flux profiles are discussed as well as heating rates and cooling requirements

  8. Monitoring Students' Academic & Disciplinary Progression.

    Science.gov (United States)

    McDonald, Fred; Kellogg, Larry J.

    This document outlines the objectives and procedures of a program at a New Mexico school district whose purpose is to enable school personnel to systematically monitor students' academic and disciplinary progression. The objectives of the program are to diagnose academic or disciplinary problems and prescribe remedies, to establish an oncampus…

  9. John Woolman and Ethical Progress in Kitcher's Pragmatic Naturalism.

    Science.gov (United States)

    Barresi, John

    2017-01-01

    The development of John Woolman’s views on slavery plays an important evidentiary role in Philip Kitcher’s recent book, The ethical project (Kitcher 2011). In this work Kitcher takes what he calls a “pragmatic naturalist” approach to ethics and claims that the discovery of ethical truth plays no role in the emergence of ethical progress. To support his view, he argues that Woolman’s contribution was not due to his discovery of an ethical truth about slavery, not previously known, but due to his sensitivity to slavery and his influence on others, which contributed to collective progressive change in moral norms involving slavery. While not disputing Kitcher’s ethical theory, I argue that personal discoveries of a moral psychological nature made by Woolman served both as insights and motivations for his contribution. Thus, even if there are no such things as independent ethical truths that can be discovered by individuals, a fully naturalistic approach to ethical progress requires that we make room not only for group-level progressive evolution of norms, but also for individual discoveries of a moral psychological nature that can sometimes cause an individual to play a significant initiating role in progressive ethical transitions that occur at a group level.

  10. Case management considerations of progressive dementia in a home setting.

    Science.gov (United States)

    Pierce, Mary Ellen

    2010-01-01

    Nursing theory, research, and best practice guidelines contribute substantially to the field of dementia care. Interventional plans are challenged most by those dementias considered progressive and deteriorative in nature, requiring ongoing reassessment and modification of care practices as the clinical course changes. The purpose of this article is to provide guidelines for case managers in the development of effective, individualized care plans for clients with progressive dementia residing in a home setting. The application of these guidelines is illustrated through the presentation of an actual case. The practice setting is a private home in the Pacific Northwest. Geriatric case management is provided by an RN case manager. Progressive dementia presents challenges to home care. Professional case management using comprehensive, holistic assessment, collaborative approaches, and best practice fundamentals serve to create an effective, individualized plan of care. The increasing geriatric population presents great opportunities for case managers in strategic management for creating successful home care models in clients with progressive dementia. Use of nursing diagnoses, dementia research, and collaborative approaches with families and other medical providers creates a viable alternative for clients with progressive dementia.

  11. Progress and bottleneck in induced pluripotency

    Directory of Open Access Journals (Sweden)

    Zhang Zhen-Ning

    2012-07-01

    Full Text Available Abstract With their capability to undergo unlimited self-renewal and to differentiate into all cell types in the body, induced pluripotent stem cells (iPSCs, reprogrammed from somatic cells of individual patients with defined factors, have unlimited potential in cell therapy and in modeling complex human diseases. Significant progress has been achieved to improve the safety of iPSCs and the reprogramming efficiency. To avoid the cancer risk and spontaneous reactivation of the reprogramming factors associated with the random integration of viral vectors into the genome, several approaches have been established to deliver the reprogramming factors into the somatic cells without inducing genetic modification. In addition, a panel of small molecule compounds, many of which targeting the epigenetic machinery, have been identified to increase the reprogramming efficiency. Despite these progresses, recent studies have identified genetic and epigenetic abnormalities of iPSCs as well as the immunogenicity of some cells derived from iPSCs. In addition, due to the oncogenic potential of the reprogramming factors and the reprogramming-induced DNA damage, the critical tumor suppressor pathways such as p53 and ARF are activated to act as the checkpoints that suppress induced pluripotency. The inactivation of these tumor suppression pathways even transiently during reprogramming processes could have significant adverse impact on the genome integrity. These safety concerns must be resolved to improve the feasibility of the clinic development of iPSCs into human cell therapy.

  12. Progress in pharmacogenetics: consortiums and new strategies.

    Science.gov (United States)

    Maroñas, Olalla; Latorre, Ana; Dopazo, Joaquín; Pirmohamed, Munir; Rodríguez-Antona, Cristina; Siest, Gérard; Carracedo, Ángel; LLerena, Adrián

    2016-03-01

    Pharmacogenetics (PGx), as a field dedicated to achieving the goal of personalized medicine (PM), is devoted to the study of genes involved in inter-individual response to drugs. Due to its nature, PGx requires access to large samples; therefore, in order to progress, the formation of collaborative consortia seems to be crucial. Some examples of this collective effort are the European Society of Pharmacogenomics and personalized Therapy and the Ibero-American network of Pharmacogenetics. As an emerging field, one of the major challenges that PGx faces is translating their discoveries from research bench to bedside. The development of genomic high-throughput technologies is generating a revolution and offers the possibility of producing vast amounts of genome-wide single nucleotide polymorphisms for each patient. Moreover, there is a need of identifying and replicating associations of new biomarkers, and, in addition, a greater effort must be invested in developing regulatory organizations to accomplish a correct standardization. In this review, we outline the current progress in PGx using examples to highlight both the importance of polymorphisms and the research strategies for their detection. These concepts need to be applied together with a proper dissemination of knowledge to improve clinician and patient understanding, in a multidisciplinary team-based approach.

  13. Effective progression of nuclear magnetic resonance-detected fragment hits.

    Science.gov (United States)

    Eaton, Hugh L; Wyss, Daniel F

    2011-01-01

    Fragment-based drug discovery (FBDD) has become increasingly popular over the last decade as an alternate lead generation tool to HTS approaches. Several compounds have now progressed into the clinic which originated from a fragment-based approach, demonstrating the utility of this emerging field. While fragment hit identification has become much more routine and may involve different screening approaches, the efficient progression of fragment hits into quality lead series may still present a major bottleneck for the broadly successful application of FBDD. In our laboratory, we have extensive experience in fragment-based NMR screening (SbN) and the subsequent iterative progression of fragment hits using structure-assisted chemistry. To maximize impact, we have applied this approach strategically to early- and high-priority targets, and those struggling for leads. Its application has yielded a clinical candidate for BACE1 and lead series in about one third of the SbN/FBDD projects. In this chapter, we will give an overview of our strategy and focus our discussion on NMR-based FBDD approaches. Copyright © 2011 Elsevier Inc. All rights reserved.

  14. Geothermal Progress Monitor report No. 5. Progress report, June 1981

    Energy Technology Data Exchange (ETDEWEB)

    1981-01-01

    Updated information is presented on activities and progress in the areas of electric power plants, direct heat applications, deep well drilling, leasing of federal lands, legislative and regulatory actions, research and development, and others. Special attention is given in this report to 1980 highlights, particularly in the areas of electric and direct heat uses, drilling, and the Federal lands leasing program. This report also includes a summary of the DOE FY 1982 geothermal budget request to Congress.

  15. Nuclear excitations and reaction mechanisms. Progress report

    International Nuclear Information System (INIS)

    Fallieros, S.; Levin, F.S.

    1986-01-01

    Theoretical research is being conducted on the following topics: photon scattering, gauge invariance and the extension of Siefert's Theorem; retardation effects in photonuclear absorption and the Cabibbo Radicati Sum Rule; isovector transition densities, currents and response functions; the electric polarizability, the magnetic susceptibility and the distribution of oscillator strengths in some elementary systems; relativistic models and processes; properties of skyrmions; multiquark compound bags and the charge form factor of the A = 3 nuclei; nuclear reaction theory; three-particle scattering theory; deuteron-nucleus model calculations; asymptotia in three-particle scattering systems; and time-dependent approach to few-nucleon collisions. Progress in each of these areas is reviewed briefly. A list of invited talks and of publications for the fiscal year 1986 is included. 27 refs

  16. Recent progress in stellarator reactor conceptual design

    International Nuclear Information System (INIS)

    Miller, R.L.

    1985-01-01

    The Stellarator/Torsatron/Heliotron (S/T/H) class of toroidal magnetic fusion reactor designs continues to offer a distinct and in several ways superior approach to eventual commercial competitiveness. Although no major, integrated conceptual reactor design activity is presently underway, a number of international research efforts suggest avenues for the substantial improvement of the S/T/H reactor embodiment, which derive from recent experimental and theoretical progress and are responsive to current trends in fusion-reactor projection to set the stage for a third generation of designs. Recent S/T/H reactor design activity is reviewed and the impact of the changing technical and programmatic context on the direction of future S/T/H reactor design studies is outlined

  17. Project Progress Assessment Report (PPAR) 2015

    International Nuclear Information System (INIS)

    Sall, Baba

    2015-01-01

    This evaluation reports reviews basic information, output achievement, equipment and human resources, comment and recommendations. It highlights outputs Fully achieved, those which are partially achieved or in progress and also non achieved outputs. Regarding comments and lessons learned, counterpart stated that the overall timeline of the project is respected, even if activities are delayed to adapt to technical, financial and human resources constraints. The results obtained are in line with expectations thanks to a rigorously respected scientific approach. The Collegial Coordination of the project (DSV-LNERV-CIRAD) and the TO are in phase on the conduct of the Project the collection of baseline data is a crucial phase in the implementation of tsetse control programs. It makes it possible to implement a good strategy. The scientific and technical rigor and the good atmosphere within the Project team are also to be retained.

  18. Project Progress Assessment Report (PPAR) 2012

    International Nuclear Information System (INIS)

    Sall, Baba

    2012-01-01

    This evaluation reports reviews basic information, output achievement, equipment and human resources, comment and recommendations. It highlights outputs Fully achieved, those which are partially achieved or in progress and also non achieved outputs. Regarding comments and lessons learned, counterpart stated that the overall timeline of the project is respected, even if activities are delayed to adapt to technical, financial and human resources constraints. The results obtained are in line with expectations thanks to a rigorously respected scientific approach. The Collegial Coordination of the project (DSV-LNERV-CIRAD) and the TO are in phase on the conduct of the Project the collection of baseline data is a crucial phase in the implementation of tsetse control programs. It makes it possible to implement a good strategy. The scientific and technical rigor and the good atmosphere within the Project team are also to be retained.

  19. Nutritionally Enhanced Food Crops; Progress and Perspectives

    Directory of Open Access Journals (Sweden)

    Kathleen L. Hefferon

    2015-02-01

    Full Text Available Great progress has been made over the past decade with respect to the application of biotechnology to generate nutritionally improved food crops. Biofortified staple crops such as rice, maize and wheat harboring essential micronutrients to benefit the world’s poor are under development as well as new varieties of crops which have the ability to combat chronic disease. This review discusses the improvement of the nutritional status of crops to make a positive impact on global human health. Several examples of nutritionally enhanced crops which have been developed using biotechnological approaches will be discussed. These range from biofortified crops to crops with novel abilities to fight disease. The review concludes with a discussion of hurdles faced with respect to public perception, as well as directions of future research and development for nutritionally enhanced food crops.

  20. Clean energy technologies : perspectives and recent progress

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, G. [Natural Resources Canada, Ottawa, ON (Canada). Office of Energy Research and Development

    2006-07-01

    There is a need to move toward a bio-based economy that offers new ways of thinking and new approaches to energy consumption and use. Bioenergy technologies can complement highly efficient fossil fuels with renewable and sustainable alternatives to achieve improved health and air quality, while reducing greenhouse gases. Perspectives on the bio-based economy and recent progress in bioenergy technologies were addressed in this presentation. The purpose was to explore the opportunities and challenges of using biomass for energy systems in industrial settings. The presentation provided information on current research being undertaken in bioenergy in the agricultural and forest fibre industries. Information on the Canadian Biomass Innovation Network (CBIN), which consists of federal researchers, program managers, policy makers and expert advisors and on its thermochemical energy systems were discussed in detail. CBIN's mission, vision, priorities, outputs, and funding were identified. Thermochemical conversion research under CBIN relates to combustion, gasification, and pyrolysis. tabs., figs.

  1. Cancer nanomedicine: progress, challenges and opportunities.

    Science.gov (United States)

    Shi, Jinjun; Kantoff, Philip W; Wooster, Richard; Farokhzad, Omid C

    2017-01-01

    The intrinsic limits of conventional cancer therapies prompted the development and application of various nanotechnologies for more effective and safer cancer treatment, herein referred to as cancer nanomedicine. Considerable technological success has been achieved in this field, but the main obstacles to nanomedicine becoming a new paradigm in cancer therapy stem from the complexities and heterogeneity of tumour biology, an incomplete understanding of nano-bio interactions and the challenges regarding chemistry, manufacturing and controls required for clinical translation and commercialization. This Review highlights the progress, challenges and opportunities in cancer nanomedicine and discusses novel engineering approaches that capitalize on our growing understanding of tumour biology and nano-bio interactions to develop more effective nanotherapeutics for cancer patients.

  2. Laser ignited engines: progress, challenges and prospects.

    Science.gov (United States)

    Dearden, Geoff; Shenton, Tom

    2013-11-04

    Laser ignition (LI) has been shown to offer many potential benefits compared to spark ignition (SI) for improving the performance of internal combustion (IC) engines. This paper outlines progress made in recent research on laser ignited IC engines, discusses the potential advantages and control opportunities and considers the challenges faced and prospects for its future implementation. An experimental research effort has been underway at the University of Liverpool (UoL) to extend the stratified speed/load operating region of the gasoline direct injection (GDI) engine through LI research, for which an overview of some of the approaches, testing and results to date are presented. These indicate how LI can be used to improve control of the engine for: leaner operation, reductions in emissions, lower idle speed and improved combustion stability.

  3. POOR PROGRESS STUDENTS IN LEARNING MATHEMATICS AS SOCIAL AND PSYCHOLOGICAL-PEDAGOGICAL PROBLEM

    OpenAIRE

    Vladimir Tatochenko; Andrii Shypko

    2016-01-01

    The article is devoted to theoretical substantiation of modern methodical system of Mathematics teaching of poor progressing secondary school pupils. A systematic approach to the study of psycho-pedagogical determinants of poor progress of pupils in math was implemented. The dynamic of interfunctional relationship of structure of educational and informative sphere of poor progressing pupils in mathematics was disclosed and scientific understanding of this process was expanded. The introducti...

  4. The Efficient Side of Progressive Income Taxation

    OpenAIRE

    Corneo, Giacomo

    2000-01-01

    This paper examines the allocative implications of progressive income taxation when individuals care about their relative income. It shows that tax progressivity might improve efficiency, and the more so in egalitarian economies. Introducing a progressive income tax can yield a Pareto improvement if pre-tax income is evenly distributed. Implementing undistorted choices of working hours requires a progressive tax schedule, and the optimal degree of progressivity decreases with pre-tax income i...

  5. Nr 150 - Private bill introducing a progressive energy tariff

    International Nuclear Information System (INIS)

    Brottes, Francois; Le Roux, Bruno

    2012-01-01

    This document presents a private bill which, by introducing a progressive energy tariff, aims at speeding up energy transition (by inciting households to reduce their consumption, notably by insulating their housing), and at addressing the ineluctable issue of energy price increase. This private bill notably applies a bonus-malus concept by defining an energy consumption threshold which is to be determined by means of several parameters related to climate, housing occupancy, heating mode. This raises several issues concerning for example housing insulation of rented housing. All these aspects lead to a rather complex process to define and implement such a progressive pricing approach

  6. [The optimization of a surgical intervention to stabilize progressive myopia].

    Science.gov (United States)

    Gonchar, P A; Dushin, N V; Beliaev, V S; Kravchinina, V V; Barashkov, V I; Frolov, M A

    1999-01-01

    Results of 236 sclera-fortifying surgeries are followed up for more than 25 years. Progressive myopia stabilized in 95.8% cases after bandaging scleroplasty and in 87.03% cases after chondroplasty. Clinical refraction and posteroanterior axis of the eye did not increase after surgery; visual functions stabilized, and brightness sensitivity threshold was lowered. The technique of operation and clinical course of the postoperative period are described. Based on analysis of the clinical material, the authors propose the optimal approach to scleroplastic operations aimed at stabilization of progressive myopia.

  7. Climate Reanalysis: Progress and Future Prospects

    Science.gov (United States)

    Gelaro, Ron

    2018-01-01

    Reanalysis is the process whereby an unchanging data assimilation system is used to provide a consistent reprocessing of observations, typically spanning an extended segment of the historical data record. The process relies on an underlying model to combine often-disparate observations in a physically consistent manner, enabling production of gridded data sets for a broad range of applications including the study of historical weather events, preparation of climatologies, business sector development and, more recently, climate monitoring. Over the last few decades, several generations of reanalyses of the global atmosphere have been produced by various operational and research centers, focusing more or less on the period of regular conventional and satellite observations beginning in the mid to late twentieth century. There have also been successful efforts to extend atmospheric reanalyses back to the late nineteenth and early twentieth centuries, using mostly surface observations. Much progress has resulted from (and contributed to) advancements in numerical weather prediction, especially improved models and data assimilation techniques, increased computing capacity, the availability of new observation types and efforts to recover and improve the quality of historical ones. The recent extension of forecast systems that allow integrated modeling of meteorological, oceanic, land surface, and chemical variables provide the basic elements for coupled data assimilation. This has opened the door to the development of a new generation of coupled reanalyses of the Earth system, or integrated Earth system analyses (IESA). Evidence so far suggests that this approach can improve the analysis of currently uncoupled components of the Earth system, especially at their interface, and lead to increased predictability. However, extensive analysis coupling as envisioned for IESA, while progressing, still presents significant challenges. These include model biases that can be

  8. Progress of MICE RFCC Module

    Energy Technology Data Exchange (ETDEWEB)

    Li, D.; Bowring, D.; DeMello, A.; Gourlay, S.; Green, M.; Li, N.; Niinikoski, T.; Pan, H.; Prestemon, S.; Virostek, S.; Zisman, M.; Bross, A.; Carcagno, R.; Kashikhin, V.; Sylvester, C.; Chen, A. B.; Guo, Bin; Li, Liyi; Xu, Fengyu; Cao, Y.; Sun, S.; Wang, Li; Yin, Lixin; Luo, Tianhuan; Summers, Don; Smith, B.; Radovinsky, A.; Zhukovsky, A.; Kaplan, D.

    2012-05-20

    Recent progress on the design and fabrication of the RFCC (RF and superconducting Coupling Coil) module for the international MICE (Muon Ionization Cooling Experiment) are reported. The MICE ionization cooling channel has two RFCC modules, each having four 201- MHz normal conducting RF cavities surrounded by one superconducting coupling coil (solenoid) magnet. The magnet is designed to be cooled by three cryocoolers. Fabrication of the RF cavities is complete; preparation for the cavity electro-polishing, low power RF measurements, and tuning are in progress at Lawrence Berkeley National Laboratory (LBNL). Fabrication of the cold mass of the first coupling coil magnet has been completed in China and the cold mass arrived at LBNL in late 2011. Preparations for testing the cold mass are currently under way at Fermilab. Plans for the RFCC module assembly and integration are being developed and are described.

  9. Progress on alternative energy resources

    Science.gov (United States)

    Couch, H. T.

    1982-03-01

    Progress in the year 1981 toward the development of energy systems suitable for replacing petroleum products combustion and growing in use to fulfill a near term expansion in energy use is reviewed. Coal is noted to be a potentially heavy pollution source, and the presence of environmentally acceptable methods of use such as fluidized-bed combustion and gasification and liquefaction reached the prototype stage in 1981, MHD power generation was achieved in two U.S. plants, with severe corrosion problems remaining unsolved for the electrodes. Solar flat plate collectors sales amounted to 20 million sq ft in 1981, and solar thermal electric conversion systems with central receivers neared completion. Solar cells are progressing toward DOE goals of $.70/peak W by 1986, while wind energy conversion sales were 2000 machines in 1981, and the industry is regarded as maturing. Finally, geothermal, OTEC, and fusion systems are reviewed.

  10. Communication of nuclear data progress

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-15

    This is the 30th issue of Communication of Nuclear Data Progress (CNDP), in which the progress and achievements in nuclear data field in China during 2004 are carried. It includes the evaluations and model calculations of neutron data for n+{sup 31}P, {sup 59}Co, {sup 92-106}Mo, {sup Nat-116}Cd, {sup 233}U and the covariance data evaluation of experimental data for {sup 27}Al, update the decay data for radionuclide {sup 7}Be. Some results of studies for nuclear evaluation tool and model are also included in this issue, i.e. reaction mechanism studies of {sup 5}He, a new method of evaluating the discrepant data, linear fit of correlative data by least squared method et al. (authors)

  11. Progress in Heavy Ion Fusion

    International Nuclear Information System (INIS)

    Herrmannsfeldt, W.B.

    1988-09-01

    The progress of the field of Heavy Ion Fusion has been documented in the proceedings of the series of International Symposia that, in recent years, have occurred every second year. The latest of these conferences was hosted by Gesellshaft fuer Schwerionenforshung (GSI) in Darmstadt, West Germany, June 28-30, 1988. For this report, a few highlights from the conference are selected, stressing experimental progress and prospects for future advances. A little extra time is devoted to report on the developments at the Lawrence Berkeley Laboratory (LBL) which is the center for most of the HIFAR program. The Director of the HIFAR program at LBL is Denis Keefe, who presented the HIF report at the last two of the meetings in this series, and in whose place the author is appearing now. 4 refs., 1 fig

  12. Communication of nuclear data progress

    International Nuclear Information System (INIS)

    2006-07-01

    This is the 30th issue of Communication of Nuclear Data Progress (CNDP), in which the progress and achievements in nuclear data field in China during 2004 are carried. It includes the evaluations and model calculations of neutron data for n+ 31 P, 59 Co, 92-106 Mo, Nat-116 Cd, 233 U and the covariance data evaluation of experimental data for 27 Al, update the decay data for radionuclide 7 Be. Some results of studies for nuclear evaluation tool and model are also included in this issue, i.e. reaction mechanism studies of 5 He, a new method of evaluating the discrepant data, linear fit of correlative data by least squared method et al. (authors)

  13. Monitoring Progress in Child Poverty Reduction: Methodological Insights and Illustration to the Case Study of Bangladesh

    Science.gov (United States)

    Roche, Jose Manuel

    2013-01-01

    Important steps have been taken at international summits to set up goals and targets to improve the wellbeing of children worldwide. Now the world also has more and better data to monitor progress. This paper presents a new approach to monitoring progress in child poverty reduction based on the Alkire and Foster adjusted headcount ratio and an…

  14. Progress in advanced accelerator concepts

    International Nuclear Information System (INIS)

    Sessler, A.M.

    1994-08-01

    A review is given of recent progress in this field, drawing heavily upon material presented at the Workshop on Advanced Accelerator Concepts, The Abbey, June 12--18, 1994. Attention is addressed to (1) plasma based concepts, (2) photo-cathodes, (3) radio frequency sources and Two-Beam Accelerators, (4) near and far-field schemes (including collective accelerators), (5) beam handling and conditioning, and (6) exotic collider concepts (such as photon colliders and muon colliders)

  15. Revolution and progress in medicine.

    Science.gov (United States)

    Goodwin, William

    2015-02-01

    This paper adapts Kuhn's conceptual framework to developmental episodes in the theory and practice of medicine. Previous attempts to understand the reception of Ignaz Semmelweis's work on puerperal fever in Kuhnian terms are used as a starting point. The author identifies some limitations of these attempts and proposes a new way of understanding the core Kuhnian notions of "paradigm," "progress," and "revolution" in the context of a socially embedded technoscience such as medicine.

  16. Progress in light cone physics

    International Nuclear Information System (INIS)

    Preparata, G.

    1973-01-01

    A very brief review is given of the progress made in the physics of the light cone in the past year. Included are the light cone expansion, gauge invariance and the consequences of precocious scaling near threshold, the light cone description of the muon pair experiment, light cone expansions, and the assessment and exploitation of analyticity properties in both mass and energy of light cone amplitudes. (U.S.)

  17. Gammasphere software development. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Piercey, R.B.

    1994-01-01

    This report describes the activities of the nuclear physics group at Mississippi State University which were performed during 1993. Significant progress has been made in the focus areas: chairing the Gammasphere Software Working Group (SWG); assisting with the porting and enhancement of the ORNL UPAK histogramming software package; and developing standard formats for Gammasphere data products. In addition, they have established a new public ftp archive to distribute software and software development tools and information.

  18. Progress Report. Teilinstitut Nukleare Festkoerperphysik

    International Nuclear Information System (INIS)

    Kaefer, K.

    1978-10-01

    This Progress Report of the Teilinstitut Nukleare Festkoerperphysik covers the work done at the Institute during the period from June 1, 1977 to May 31, 1978. The main research areas presently under investigation are underlined by the arrangement of the report: structure and dynamics of solids, electronic structure and magnetism of solids, and the development and investigation of novel materials. Some technical developments important in carrying out this research are included as well. (orig.) [de

  19. Progress in food irradiation: Australia

    Energy Technology Data Exchange (ETDEWEB)

    Wills, P A

    1982-11-01

    Progress in food irradiation treatment of Australian commodities, such as meat, pepper, honey, fruit is described. Irradiation took place with /sup 60/Co gamma radiation while testing for radiation sensitivity of Staphyllococcus in meat, of Bacillus aureus in pepper, of Streptococcus plutin and Bacillus larvae in honey, and of the fruitfly Dacus tryoni infesting fruit. So far, two State Health Commissions in Australia have authorised irradiation of shrimps with their sale being restricted to the State authorising treatment.

  20. Progress in food irradiation: Australia

    International Nuclear Information System (INIS)

    Wills, P.A.

    1982-01-01

    Progress in food irradiation treatment of Australian commodities, such as meat, pepper, honey, fruit is described. Irradiation took place with 60 Co gamma radiation while testing for radiation sensitivity of Staphyllococcus in meat, of Bacillus aureus in pepper, of Streptococcus plutin and Bacillus larvae in honey, and of the fruitfly Dacus tryoni infesting fruit. Sofar, two State Health Commissions in Australia have authorised irradiation of shrimps with their sale being restricted to the State authorising treatment. (AJ) [de

  1. The 1989 progress report: Mathematics

    International Nuclear Information System (INIS)

    Demazure, M.

    1989-01-01

    The 1989 progress report of the laboratory of Mathematics of the Polytechnic School (France) is presented. The investigations reported were performed in the following fields: analysis of nonlinear partial differential equations, quantum mechanics, scattering, fluid dynamics and homogenization, equations, varieties with negative curvature, elliptical problems on surfaces, Dirac operator, geometry of algorithms and formal calculus, singularities, Lie groups, dynamics systems. The published papers, the conferences and the Laboratory staff are listed [fr

  2. Progressive Taxes and Firm Births

    OpenAIRE

    Hans Ulrich Bacher; Marius Brülhart

    2013-01-01

    Tax reform proposals in the spirit of the 'flat tax' model typically aim to reduce three parameters: the average tax burden, the progressivity of the tax schedule, and the complexity of the tax code. We explore the implications of changes in these three parameters on entrepreneurial activity, measured by counts of firm births. The Swiss fiscal system offers sufficient intra-national variation in tax codes to allow us to estimate these effects with considerable precision. We find that high ave...

  3. NADPH Oxidases: Progress and Opportunities

    OpenAIRE

    San Martin, Alejandra; Griendling, Kathy K.

    2014-01-01

    From the initial discovery in 1999 that NADPH oxidases comprise a family of enzymes to our current focus on drug development to treat multiple pathologies related to this enzyme family, progress has been swift and impressive. We have expanded our understanding of the extent of the family, the basic enzymatic biochemistry, the multiple cellular functions controlled by NADPH oxidases, and their varied roles in physiology and diseases. We have developed numerous cell culture tools, animal models...

  4. Progress Toward Heavy Ion IFE

    International Nuclear Information System (INIS)

    Meier, W.R.; Logan, B.G.; Waldron, W.L.; Sabbi, G.L.; Callahan-Miller, D.A.; Peterson, P.F.; Goodin, D.T.

    2002-01-01

    Successful development of Heavy Ion Fusion (HIF) will require scientific and technology advances in areas of targets, drivers and chambers. Design work on heavy ion targets indicates that high gain (60-130) may be possible with a -3-6 MJ driver depending on the ability to focus the beams to small spot sizes. Significant improvements have been made on key components of heavy ion drivers, including sources, injectors, insulators and ferromagnetic materials for long-pulse induction accelerator cells, solid-state pulsers, and superconducting quadrupole magnets. The leading chamber concept for HIF is the thick-liquid-wall HYLEE-II design, which uses an array of flibe jets to protect chamber structures from x-ray, debris, and neutron damage. Significant progress has been made in demonstrating the ability to create and control the types of flow needed to form the protective liquid blanket. Progress has also been made on neutron shielding for the final focus magnet arrays with predicted lifetimes now exceeding the life of the power plant. Safety analyses have been completed for the HYLEE-II design using state-of-the-art codes. Work also continues on target fabrication and injection for HE. A target injector experiment capable of > 5 Hz operation has been designed and construction will start in 2002. Methods for mass production of hohlraum targets are being evaluated with small-scale experiments and analyses. Progress in these areas will be reviewed

  5. Information Loss from Technological Progress

    International Nuclear Information System (INIS)

    Townsend, P D

    2014-01-01

    Progress in electronics and optics offers faster computers, and rapid communication via the internet that is matched by ever larger and evolving storage systems. Instinctively one assumes that this must be totally beneficial. However advances in software and storage media are progressing in ways which are frequently incompatible with earlier systems and the economics and commercial pressures rarely guarantee total compatibility with earlier systems. Instead, the industries actively choose to force the users to purchase new systems and software. Thus we are moving forward with new technological variants that may have access to only the most recent systems and we will have lost earlier alternatives. The reality is that increased processing speed and storage capacity are matched by an equally rapid decline in the access and survival lifetime of older information. This pattern is not limited to modern electronic systems but is evident throughout history from writing on stone and clay tablets to papyrus and paper. It is equally evident in image systems from painting, through film, to magnetic tapes and digital cameras. In sound recording we have variously progressed from wax discs to vinyl, magnetic tape and CD formats. In each case the need for better definition and greater capacity has forced the earlier systems into oblivion. Indeed proposed interactive music systems could similarly relegate music CDs to specialist collections. The article will track some of the examples and discuss the consequences as well as noting that this information loss is further compounded by developments in language and changes in cultural views of different societies

  6. Information Loss from Technological Progress

    Science.gov (United States)

    Townsend, P. D.

    2014-12-01

    Progress in electronics and optics offers faster computers, and rapid communication via the internet that is matched by ever larger and evolving storage systems. Instinctively one assumes that this must be totally beneficial. However advances in software and storage media are progressing in ways which are frequently incompatible with earlier systems and the economics and commercial pressures rarely guarantee total compatibility with earlier systems. Instead, the industries actively choose to force the users to purchase new systems and software. Thus we are moving forward with new technological variants that may have access to only the most recent systems and we will have lost earlier alternatives. The reality is that increased processing speed and storage capacity are matched by an equally rapid decline in the access and survival lifetime of older information. This pattern is not limited to modern electronic systems but is evident throughout history from writing on stone and clay tablets to papyrus and paper. It is equally evident in image systems from painting, through film, to magnetic tapes and digital cameras. In sound recording we have variously progressed from wax discs to vinyl, magnetic tape and CD formats. In each case the need for better definition and greater capacity has forced the earlier systems into oblivion. Indeed proposed interactive music systems could similarly relegate music CDs to specialist collections. The article will track some of the examples and discuss the consequences as well as noting that this information loss is further compounded by developments in language and changes in cultural views of different societies.

  7. Demyelination versus remyelination in progressive multiple sclerosis

    DEFF Research Database (Denmark)

    Bramow, Stephan; Frischer, Josa M; Lassmann, Hans

    2010-01-01

    The causes of incomplete remyelination in progressive multiple sclerosis are unknown, as are the pathological correlates of the different clinical characteristics of patients with primary and secondary progressive disease. We analysed brains and spinal cords from 51 patients with progressive...... multiple sclerosis by planimetry. Thirteen patients with primary progressive disease were compared with 34 with secondary progressive disease. In patients with secondary progressive multiple sclerosis, we found larger brain plaques, more demyelination in total and higher brain loads of active demyelination...... compared with patients with primary progressive disease. In addition, the brain density of plaques with high-grade inflammation and active demyelination was highest in secondary progressive multiple sclerosis and remained ~18% higher than in primary progressive multiple sclerosis after adjustments...

  8. What is the Integral in Integral Education? From Progressive Pedagogy to Integral Pedagogy

    Directory of Open Access Journals (Sweden)

    Tom Murray

    2009-06-01

    Full Text Available Integrally-informed educational approaches have much in common withprogressive (including reform, alternative, holistic, and transformative approaches, andshare many of the same values. One function of the integral approach is to provide anoverarching model within which to coordinate different progressive methods. Thoughintegral adds much more than that, descriptions of integral education sometimes soundlike progressive educational principles recast with new terminology. This essay attemptsto clarify what the integral approach adds over and above progressive educationaltheories. After an overview of progressive pedagogical principles, the integral approachis discussed in terms of integral as a model, a method, a community, and a developmentalstage. Integral as a type of consciousness or developmental level is elaborated upon asconsisting of construct-awareness, ego-awareness, relational-awareness, and systemawareness,all important to the educational process. Finally, challenges and supportsystems for realizing integral education are discussed.

  9. White Matter Lesion Progression in LADIS

    DEFF Research Database (Denmark)

    Schmidt, Reinhold; Berghold, Andrea; Jokinen, Hanna

    2012-01-01

    BACKGROUND AND PURPOSE: White matter lesion (WML) progression has been advocated as a surrogate marker in intervention trials on cerebral small vessel disease. We assessed the rate of visually rated WML progression, studied correlations between lesion progression and cognition, and estimated sample...... sizes for clinical trials with pure WML progression vs combined WML progression-cognitive outcomes. METHODS: Those 394 participants of the Leukoaraiosis and Disability Study (LADIS) study with magnetic resonance imaging scanning at baseline and 3-year follow-up were analyzed. WML progression rating...

  10. Radiative Cooling: Principles, Progress, and Potentials

    Science.gov (United States)

    Hossain, Md. Muntasir

    2016-01-01

    The recent progress on radiative cooling reveals its potential for applications in highly efficient passive cooling. This approach utilizes the maximized emission of infrared thermal radiation through the atmospheric window for releasing heat and minimized absorption of incoming atmospheric radiation. These simultaneous processes can lead to a device temperature substantially below the ambient temperature. Although the application of radiative cooling for nighttime cooling was demonstrated a few decades ago, significant cooling under direct sunlight has been achieved only recently, indicating its potential as a practical passive cooler during the day. In this article, the basic principles of radiative cooling and its performance characteristics for nonradiative contributions, solar radiation, and atmospheric conditions are discussed. The recent advancements over the traditional approaches and their material and structural characteristics are outlined. The key characteristics of the thermal radiators and solar reflectors of the current state‐of‐the‐art radiative coolers are evaluated and their benchmarks are remarked for the peak cooling ability. The scopes for further improvements on radiative cooling efficiency for optimized device characteristics are also theoretically estimated. PMID:27812478

  11. Nuclear theory. 1998 progress report

    International Nuclear Information System (INIS)

    1998-01-01

    Summaries of progress made on the following topics are given: (1) nonresonant contributions to inelastic N→Δ(1232) parity violation; (2) neutron distribution effects in elastic nuclear parity violation; (3) Wilson RG for scalar-plus-fermion field theories at finite density; (4) Perturbation theory for spin ladders using angular momentum coupled bases; (5) mean-field theory for spin ladders using angular momentum density; (6) finite temperature renormalization group effective potentials for the linear Sigma model; (7) negative-parity baryon resonances from lattice QCD; (8) the N→Δ electromagnetic transition amplitudes from QCD sum rules; and (9) higher nucleon resonances in exclusive reactions (γ, πN) on nuclei

  12. Progress of JPDR decommissioning project

    International Nuclear Information System (INIS)

    Kiyota, M.; Yanagihara, S.

    1995-01-01

    The Japan Power Demonstration Reactor (JPDR) decommissioning project is progressively achieving its final goal; the project will be finished by March 1996 to release the JPDR's site into unrestricted use in a green field condition. The new techniques which developed or improved in R and D, the first phase of this program, have been successfully applied to the actual dismantling activities. Some decommissioning wastes have been managed as the first case of onsite shallow land burial based on the new regulatory frame of radioactive waste management. The experiences and the data obtained from the JPDR dismantling activities are expected to contribute to future decommissioning of commercial nuclear power plants. (author)

  13. Nuclear spectroscopic studies. Progress report

    International Nuclear Information System (INIS)

    Bingham, C.R.; Riedinger, L.L.; Sorensen, S.P.

    1996-01-01

    This report describes progress in the experimental nuclear physics program of the University of Tennessee, Knoxville. It presents findings related to properties of high-spin states, low-energy levels of nuclei far from stability, and high-energy heavy-ion physics, as well as a brief description of the Joint Institute of Heavy Ion Research (a collaboration between the University of Tennessee, Vanderbilt University, and Oak Ridge National Laboratory) and its activities (particularly those of the last few years), and a list of publications. 89 refs., 18 figs., 5 tabs

  14. 1995-1996 progress report

    International Nuclear Information System (INIS)

    1997-09-01

    This progress report is mainly devoted to the scientific activity of the LLB or carried out in collaboration with external laboratories. The activity of the LLB is split in several chapters dealing with: magnetism, superconductivity, structures (including lattice dynamics), phase transitions, C 60 , quasi-crystal systems, disordered systems (amorphous, liquids, crystal solid solutions), biology, soft matter (polymers and colloids), physical metallurgy and materials science. Neutron scattering is the main tool used in all these topics but other techniques are also used such as: polarized neutron reflectivity, cold neutrons diffraction, NMR, synchrotron radiation etc. (J.S.)

  15. Biobehavioral Influences on Cancer Progression

    Science.gov (United States)

    Costanzo, Erin S.; Sood, Anil K.; Lutgendorf, Susan K.

    2010-01-01

    Synopsis This review focuses on the contributions of stress-related behavioral factors to cancer growth and metastasis and the biobehavioral mechanisms underlying these relationships. We describe behavioral factors that are important in modulation of the stress response and the pivotal role of neuroendocrine regulation in the downstream alteration of physiological pathways relevant to cancer control, including the cellular immune response, inflammation, and tumor angiogenesis, invasion, and cell-signaling pathways. Consequences for cancer progression and metastasis, as well as quality of life, are delineated. Finally, behavioral and pharmacological interventions for cancer patients with the potential to alter these biobehavioral pathways are discussed. PMID:21094927

  16. Rietspruit - a pattern for progress

    Energy Technology Data Exchange (ETDEWEB)

    Holz, P.

    1991-02-01

    Operations at the Rietspruit coal export mine, opened in November 1976 as a joint venture between Rand Mines and Shell South Africa, are described. The mines initial two pits are to be joined by the end of 1991 and a new pit was opened in 1988. Removal of overburden using the throw blasting technique is described. Use of explosives such as emulsions, Anfo and packaged explosives have reduced costs. A small underground mining operation began in 1990. Present reserves should give the mine a lifetime of 10-12 years and a rehabilitation programme is in progress to restore mined land to its original state. 11 photos.

  17. Synroc - progress and future prospects

    International Nuclear Information System (INIS)

    Jostsons, A.

    2001-01-01

    Most of the early development of SYNROC focused on the SYNROC-C formulation for immobilising liquid HLW from the reprocessing of commercial LWR spent fuel. Subsequently, ANSTO has responded to developments in R and D on partitioning and transmutation, excess plutonium disposition and the needs of global remediation programs by developing a variety of titanate ceramic waste forms for specific applications. This paper reviews the progress in the development of titanate ceramics and ceramic/glass composites and addresses the relevance of this work in future radioactive waste management strategies

  18. [Research Progress on Forensic Entomotoxicology].

    Science.gov (United States)

    Liu, Zhi-jiang; Zhai, Xian-dun; Guan, Ling; Mo, Yao-nan

    2015-06-01

    Forensic entomotoxicology is a branch of forensic medicine, which applies entomology, toxicology and other related studies to solve the poisoning cases. It has an obvious advantage in the investigation on poisoning death. Based on the expounding definition and research of entomotoxicology, this paper reviews research progress and application value in some aspects of forensic medicine, such as the effects of drugs/toxins on the growth and development of sarcosaphagous insects and the qualitative and quantitative analysis of the drugs/toxins in the poisoned body tissue.

  19. Theory investigation progress of DMAZ

    Science.gov (United States)

    Xie, Hui; Mu, Xiaogang; Zhang, Yue; Wang, Xuanjun

    2017-05-01

    The recent progress in the theoretical study of N, N-dimethyl-2-azidoethylamine (DMAZ), a new type of azide fuel, is summarized. Thermodynamic Properties (such as Enthalpy-of-Formation, Enthalpy-of-Vaporization, and Enthalpy-of-Sublimation), conformers, Spectrums, the Henry's constant, ignition delay et al. are studied by Density Functional Theory (DFT). It is proved that DMAZ has good performance with a density impulse 2.499 Ns/m3, and has a good application prospect in replacing the traditional hydrazine propellant methyl-hydrazine (MMH).

  20. Nuclear electricity - a progress report

    International Nuclear Information System (INIS)

    England, G.

    1980-01-01

    A survey of the progress of nuclear power over the past three years reveals three major features: (i) the continued operation of the first generation of commercial nuclear power stations, based on the Magnox gas-cooled reactor; (ii) the introduction and operation of the first of the second-generation stations, based on the advanced gas-cooled reactor (AGR); and (iii) the commitment of two successive Governments to a flexible thermal reactor strategy. Each of these features is considered and a number of related issues, including the safety record and cost savings to the electricity consumer, are discussed. (author)

  1. [Research progress on wetland ecotourism].

    Science.gov (United States)

    Wang, Li-Long; Lu, Lin

    2009-06-01

    Wetland is rich in biodiversity and cultural diversity, possessing higher tourism value and environmental education and community participation functions. Wetland ecotourism reflects the sustainable development of tourism economy and wetland protection, having received great concern from governments and scholars at home and abroad. This paper summarized the related theories and practices, discussed the research advances in wetland ecotourism from the aspects of significance, progress, contents, methods and results, and pointed out the important research fields in the future, aimed to accelerate the development of wetland ecotourism research and to provide reference about the resources exploitation, environment protection, and scientific administration of wetland and related scenic areas.

  2. Preemptive mechanical ventilation can block progressive acute lung injury.

    Science.gov (United States)

    Sadowitz, Benjamin; Jain, Sumeet; Kollisch-Singule, Michaela; Satalin, Joshua; Andrews, Penny; Habashi, Nader; Gatto, Louis A; Nieman, Gary

    2016-02-04

    Mortality from acute respiratory distress syndrome (ARDS) remains unacceptable, approaching 45% in certain high-risk patient populations. Treating fulminant ARDS is currently relegated to supportive care measures only. Thus, the best treatment for ARDS may lie with preventing this syndrome from ever occurring. Clinical studies were examined to determine why ARDS has remained resistant to treatment over the past several decades. In addition, both basic science and clinical studies were examined to determine the impact that early, protective mechanical ventilation may have on preventing the development of ARDS in at-risk patients. Fulminant ARDS is highly resistant to both pharmacologic treatment and methods of mechanical ventilation. However, ARDS is a progressive disease with an early treatment window that can be exploited. In particular, protective mechanical ventilation initiated before the onset of lung injury can prevent the progression to ARDS. Airway pressure release ventilation (APRV) is a novel mechanical ventilation strategy for delivering a protective breath that has been shown to block progressive acute lung injury (ALI) and prevent ALI from progressing to ARDS. ARDS mortality currently remains as high as 45% in some studies. As ARDS is a progressive disease, the key to treatment lies with preventing the disease from ever occurring while it remains subclinical. Early protective mechanical ventilation with APRV appears to offer substantial benefit in this regard and may be the prophylactic treatment of choice for preventing ARDS.

  3. Central Blood Pressure and Chronic Kidney Disease Progression

    Directory of Open Access Journals (Sweden)

    Debbie L. Cohen

    2011-01-01

    Full Text Available Hypertension, diabetes, and proteinuria are well-recognized risk factors for progressive kidney function loss. However, despite excellent antihypertensive and antidiabetic drug therapies, which also often lower urinary protein excretion, there remains a significant reservoir of patients with chronic kidney disease who are at high risk for progression to end-stage kidney disease. This has led to the search for less traditional cardiovascular risk factors that will help stratify patients at risk for more rapid kidney disease progression. Among these are noninvasive estimates of vascular structure and function. Arterial stiffness, manifested by the pulse wave velocity in the aorta, has been established in a number of studies as a significant risk factor for kidney disease progression and cardiovascular endpoints. Much less well studied in chronic kidney disease are measures of central arterial pressures. In this paper we cover the physiology behind the generation of the central pulse wave contour and the studies available using these approaches and conclude with some speculations on the rationale for why measurements of central pressure may be informative for the study of chronic kidney disease progression.

  4. Fluor Hanford Project Focused Progress at Hanford

    International Nuclear Information System (INIS)

    HANSON, R.D.

    2000-01-01

    Fluor Hanford is making significant progress in accelerating cleanup at the Hanford site. This progress consistently aligns with a new strategic vision established by the U.S. Department of Energy's Richland Operations Office (RL)

  5. Progress towards Continental River Dynamics modeling

    Science.gov (United States)

    Yu, Cheng-Wei; Zheng, Xing; Liu, Frank; Maidment, Daivd; Hodges, Ben

    2017-04-01

    The high-resolution National Water Model (NWM), launched by U.S. National Oceanic and Atmospheric Administration (NOAA) in August 2016, has shown it is possible to provide real-time flow prediction in rivers and streams across the entire continental United States. The next step for continental-scale modeling is moving from reduced physics (e.g. Muskingum-Cunge) to full dynamic modeling with the Saint-Venant equations. The Simulation Program for River Networks (SPRNT) provides a computational approach for the Saint-Venant equations, but obtaining sufficient channel bathymetric data and hydraulic roughness is seen as a critical challenge. However, recent work has shown the Height Above Nearest Drainage (HAND) method can be applied with the National Elevation Dataset (NED) to provide automated estimation of effective channel bathymetry suitable for large-scale hydraulic simulations. The present work examines the use of SPRNT with the National Hydrography Dataset (NHD) and HAND-derived bathymetry for automated generation of rating curves that can be compared to existing data. The approach can, in theory, be applied to every stream reach in the NHD and thus provide flood guidance where none is available. To test this idea we generated 2000+ rating curves in two catchments in Texas and Alabama (USA). Field data from the USGS and flood records from an Austin, Texas flood in May 2015 were used as validation. Large-scale implementation of this idea requires addressing several critical difficulties associated with numerical instabilities, including ill-posed boundary conditions generated in automated model linkages and inconsistencies in the river geometry. A key to future progress is identifying efficient approaches to isolate numerical instability contributors in a large time-space varying solution. This research was supported in part by the National Science Foundation under grant number CCF-1331610.

  6. Individual moral development and moral progress

    OpenAIRE

    Schinkel, Anders; de Ruyter, Doret J.

    2017-01-01

    At first glance, one of the most obvious places to look for moral progress is in individuals, in particular in moral development from childhood to adulthood. In fact, that moral progress is possible is a foundational assumption of moral education. Beyond the general agreement that moral progress is not only possible but even a common feature of human development things become blurry, however. For what do we mean by ‘progress’? And what constitutes moral progress? Does the idea of individual m...

  7. Statistical Basis for Predicting Technological Progress

    Science.gov (United States)

    Nagy, Béla; Farmer, J. Doyne; Bui, Quan M.; Trancik, Jessika E.

    2013-01-01

    Forecasting technological progress is of great interest to engineers, policy makers, and private investors. Several models have been proposed for predicting technological improvement, but how well do these models perform? An early hypothesis made by Theodore Wright in 1936 is that cost decreases as a power law of cumulative production. An alternative hypothesis is Moore's law, which can be generalized to say that technologies improve exponentially with time. Other alternatives were proposed by Goddard, Sinclair et al., and Nordhaus. These hypotheses have not previously been rigorously tested. Using a new database on the cost and production of 62 different technologies, which is the most expansive of its kind, we test the ability of six different postulated laws to predict future costs. Our approach involves hindcasting and developing a statistical model to rank the performance of the postulated laws. Wright's law produces the best forecasts, but Moore's law is not far behind. We discover a previously unobserved regularity that production tends to increase exponentially. A combination of an exponential decrease in cost and an exponential increase in production would make Moore's law and Wright's law indistinguishable, as originally pointed out by Sahal. We show for the first time that these regularities are observed in data to such a degree that the performance of these two laws is nearly the same. Our results show that technological progress is forecastable, with the square root of the logarithmic error growing linearly with the forecasting horizon at a typical rate of 2.5% per year. These results have implications for theories of technological change, and assessments of candidate technologies and policies for climate change mitigation. PMID:23468837

  8. Statistical basis for predicting technological progress.

    Directory of Open Access Journals (Sweden)

    Béla Nagy

    Full Text Available Forecasting technological progress is of great interest to engineers, policy makers, and private investors. Several models have been proposed for predicting technological improvement, but how well do these models perform? An early hypothesis made by Theodore Wright in 1936 is that cost decreases as a power law of cumulative production. An alternative hypothesis is Moore's law, which can be generalized to say that technologies improve exponentially with time. Other alternatives were proposed by Goddard, Sinclair et al., and Nordhaus. These hypotheses have not previously been rigorously tested. Using a new database on the cost and production of 62 different technologies, which is the most expansive of its kind, we test the ability of six different postulated laws to predict future costs. Our approach involves hindcasting and developing a statistical model to rank the performance of the postulated laws. Wright's law produces the best forecasts, but Moore's law is not far behind. We discover a previously unobserved regularity that production tends to increase exponentially. A combination of an exponential decrease in cost and an exponential increase in production would make Moore's law and Wright's law indistinguishable, as originally pointed out by Sahal. We show for the first time that these regularities are observed in data to such a degree that the performance of these two laws is nearly the same. Our results show that technological progress is forecastable, with the square root of the logarithmic error growing linearly with the forecasting horizon at a typical rate of 2.5% per year. These results have implications for theories of technological change, and assessments of candidate technologies and policies for climate change mitigation.

  9. Particle beam fusion progress report for 1989

    International Nuclear Information System (INIS)

    Sweeney, M.A.

    1994-08-01

    This report summarizes the progress on the pulsed power approach to inertial confinement fusion. In 1989, the authors achieved a proton focal intensity of 5 TW/cm 2 on PBFA-II in a 15-cm-radius applied magnetic-field (applied-B) ion diode. This is an improvement by a factor of 4 compared to previous PBFA-II experiments. They completed development of the three-dimensional (3-D), electromagnetic, particle-in-cell code QUICKSILVER and obtained the first 3-D simulations of an applied-B ion diode. The simulations, together with analytic theory, suggest that control of electromagnetic instabilities could reduce ion divergence. In experiments using a lithium fluoride source, they delivered 26 kJ of lithium energy to the diode axis. Rutherford-scattered ion diagnostics have been developed and tested using a conical foil located inside the diode. They can now obtain energy density profiles by using range filters and recording ion images on nuclear track recording film. Timing uncertainties in power flow experiments on PBFA-II have been reduced by a factor of 5. They are investigating three plasma opening switches that use magnetic fields to control and confine the injected plasma. These new switches provide better power flow than the standard plasma erosion switch. Advanced pulsed-power fusion drivers will require extraction-geometry applied-B ion diodes. During this reporting period, progress was made in evaluating the generation, transport, and focus of multiple ion beams in an extraction geometry and in assessing the probable damage to a target chamber first wall

  10. Alternative energies. Updates on progress

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, German (ed.) [CIRCE - Centre of Research for Energy Resources and Consumption, Zaragoza (Spain)

    2013-07-01

    Presents fundamental and applied research of alternative energies. Address key pillars in the alternative energy field, such as: biomass energy, hydrogen energy, solar energy, wind energy, hydroelectric power, geothermal energy and their environmental implications, with the most updated progress. Includes the life cycle assessment and thermoeconomic analysis as tools for evaluating and optimising environmental and cost subjects. This book presents nine chapters based on fundamental and applied research of alternative energies. At the present time, the challenge is that technology has to come up with solutions that can provide environmentally friendly energy supply options that are able to cover the current world energy demand. Experts around the world are working on these issues for providing new solutions that will break the existing technological barriers. This book aims to address key pillars in the alternative energy field, such as: biomass energy, hydrogen energy, solar energy, wind energy, hydroelectric power, geothermal energy and their environmental implications, with the most updated progress for each pillar. It also includes the life cycle assessment (LCA) and thermoeconomic analysis (TA) as tools for evaluating and optimising environmental and cost subjects. Chapters are organized into fundamental research, applied research and future trends; and written for engineers, academic researches and scientists.

  11. LIFE: Recent Developments and Progress

    International Nuclear Information System (INIS)

    Anklam, T.M.

    2011-01-01

    Test results from the NIF show excellent progress toward achieving ignition. Experiments designed to verify coupling of the laser energy to the fusion target have shown that the efficiency meets that needed for ignition. Several tests with the cryogenic targets needed for ignition have been performed, and world-record neutron output produced. The National Ignition Campaign is on schedule to meet its 2012 ignition milestone, with the next phase in the campaign due to start later this month. It has been a busy and very productive year. The NIF is in full 24/7 operations and has progressed markedly in the path toward ignition. The long-standing goal of the National Ignition Campaign to demonstrate ignition by the end of FY 2012 is on track. The LIFE plant design has matured considerably, and a delivery plan established based on close interactions with vendors. National-level reviews of fusion are underway, and are due to present initial findings later this year. A value proposition has been drafted for review. The LIFE project is ready to move into the delivery phase.

  12. Joyo progress report, vol. 8

    International Nuclear Information System (INIS)

    1983-01-01

    Following Joyo Reactor Technology Progress Reports (Vol. 1 to Vol. 7), the name was changed to Joyo Progress Report from this volume, and the activities concerning the fast breeder experimental reactor Joyo as a whole are to be reported as quarterly report. In the fast breeder experimental reactor Joyo, the change to the core for irradiation (MK-2) from the core for breeding (MK-1) was carried out since January, 1982, in order to utilize the reactor as an irradiation facility for the development of fuel and materials. The main work was the construction of the core for irradiation by exchanging 290 fuel elements, and the exchange of upper and lower guide pipes for control rods, the reconstruction of the driving mechanism, the installation of standby neutron detector system, the acceptance and inspection of new fuel, and the transfer of spent fuel between pools were carried out. As scheduled, the core for irradiation attained the initial criticality on November 22, and the works of constructing the core were completed on December 23, 1982. Thereafter, the 100 MW performance test was begun. Various experience and valuable data were obtained in the regular inspection and the maintenance and repair works carried out at the same time, regarding the operation and maintenance of the Joyo facilities. (Kako, I.)

  13. Climate economics in progress 2011; Climate economics in progress 2011

    Energy Technology Data Exchange (ETDEWEB)

    De Perthuis, Christian [Paris-Dauphine University (France); Jouvet, Pierre-Andre [Paris-Ouest University (France); Trotignon, Raphael; Simonet, Gabriela; Boutueil, Virginie [Climate Economics Chair, Paris-Dauphine University (France)

    2011-10-01

    Climate Economics in Progress offers a global overview of the present status of action on climate change. Drawing on the most recent data, it analyzes the development of carbon markets in Europe and other parts of the world. It also examines the conditions for including major players such as China and new sectors such as agriculture, forestry and transport in the fight against global warming. The book is essential reading for anyone wishing to understand current advances in climate control, which could pave the way for a new form of economic growth. The book brings together a group of researchers whose goal is to make the link between academic research on the economics of climate change and the implementation of operational tools, thereby allowing the climate issue to be integrated into the functioning of the real economy

  14. Progress in radioactive graphite waste management

    International Nuclear Information System (INIS)

    2010-07-01

    Radioactive graphite constitutes a major waste stream which arises during the decommissioning of certain types of nuclear installations. Worldwide, a total of around 250 000 tonnes of radioactive graphite, comprising graphite moderators and reflectors, will require management solutions in the coming years. 14 C is the radionuclide of greatest concern in nuclear graphite; it arises principally through the interaction of reactor neutrons with nitrogen, which is present in graphite as an impurity or in the reactor coolant or cover gas. 3 H is created by the reactions of neutrons with 6 Li impurities in graphite as well as in fission of the fuel. 36 Cl is generated in the neutron activation of chlorine impurities in graphite. Problems in the radioactive waste management of graphite arise mainly because of the large volumes requiring disposal, the long half-lives of the main radionuclides involved and the specific properties of graphite - such as stored Wigner energy, graphite dust explosibility and the potential for radioactive gases to be released. Various options for the management of radioactive graphite have been studied but a generally accepted approach for its conditioning and disposal does not yet exist. Different solutions may be appropriate in different cases. In most of the countries with radioactive graphite to manage, little progress has been made to date in respect of the disposal of this material. Only in France has there been specific thinking about a dedicated graphite waste-disposal facility (within ANDRA): other major producers of graphite waste (UK and the countries of the former Soviet Union) are either thinking in terms of repository disposal or have no developed plans. A conference entitled 'Solutions for Graphite Waste: a Contribution to the Accelerated Decommissioning of Graphite Moderated Nuclear Reactors' was held at the University of Manchester 21-23 March 2007 in order to stimulate progress in radioactive graphite waste management

  15. Individual moral development and moral progress

    NARCIS (Netherlands)

    Schinkel, Anders; de Ruyter, Doret J.

    At first glance, one of the most obvious places to look for moral progress is in individuals, in particular in moral development from childhood to adulthood. In fact, that moral progress is possible is a foundational assumption of moral education. Beyond the general agreement that moral progress is

  16. Individual Moral Development and Moral Progress

    NARCIS (Netherlands)

    Schinkel, Anders; de Ruyter, Doret J.

    2017-01-01

    At first glance, one of the most obvious places to look for moral progress is in individuals, in particular in moral development from childhood to adulthood. In fact, that moral progress is possible is a foundational assumption of moral education. Beyond the general agreement that moral progress is

  17. Earnings progression, human capital and incentives

    DEFF Research Database (Denmark)

    Frederiksen, Anders

    progression by investigating the effects of on-the-job human capital acquisition, explicit short-run incentives and career concern incentives on earnings progression. The model leads to predictions about the incentive structure and the progression in both cross-sectional and individual earnings which...

  18. Does More Progressive Tax Make Tax Discipline Weaker?

    OpenAIRE

    Tatiana Damjanovic

    2005-01-01

    This paper investigates the relationship between the disparity in tax base and tax collection. I address the tax collection problem with traditional industrial organization approach. Thus, I model the "tax minimization" industry where the supplier helps taxpayers to avoid their tax liability. I find that lower income inequality as well as a less progressive tax code may result in a smaller number of tax payers committing to their tax duties. Finally, I question the reduction in the highest ta...

  19. Progression Trend of Critical Thinking among Nursing Students in Iran.

    OpenAIRE

    Simin Sharif; Azizollah Arbabisarjou; Nasrin Mahmoudi

    2017-01-01

    Critical thinking is defined as a basic skill for nurses which leads to the best performance based on the best existing evidence. Although acquisition of this skill is highly emphasized, still there is no single definition for it. considering importance of critical thinking in performing nursing clinical care, current study was conducted aiming at investigating critical thinking progressive trend among nursing students in a nine-year period using library approach. Methods: This sy...

  20. WHIPJET progress on piping restraint elimination at Beaver Valley - 2

    International Nuclear Information System (INIS)

    Server, W.L.; Szy Slow Ski, J.J.; Goldstein, N.A.

    1986-01-01

    Fracture mechanics technology has advanced to the point that an engineering approach using the concept of leak-before-break in lieu of postulating double-ended pipe rupture is now possible. An approach based upon this fracture mechanics technology, termed WHIPJET, is currently being applied to Beaver Valley Power Station, Unit 2 for Duquesne Light Company. The WHIPJET philosophy is simple, conservative, and provides defense-in-depth arguments for high energy piping throughout the balance-of-plant. Progress being made in applying WHIPJET to several lines is presented

  1. Imaging in primary progressive aphasia

    International Nuclear Information System (INIS)

    Abe, K.; Ukita, H.; Yanagihara, T.

    1997-01-01

    Primary progressive aphasia (PPA) presents with aphasia, with or without other minor cognitive dysfunction. We report five patients with PPA to show the correlation between their clinical signs and imaging findings. The patients can be divided into those with nonfluent (group 1) and those with fluent (group 2) aphasia. The characteristic speech impairment was bradylalia in group 1 and word amnesia in group 2. Impairment of comprehension was common but mild in both groups. On MRI, patients in group 1 showed predominantly left frontal and perisylvian atrophy with reduced uptake in the same region on single photon emission computed tomography (SPECT) using technetium-99m hexamethyl propyleneamine oxime ( 99m Tc HMPAO). Patients in group 2 showed left temporal atrophy involving the superior, middle and inferior temporal gyri, hippocampus and parahippocampal gyrus on MRI and reduced uptake in the same region on SPECT. These findings correlated well with the functional anatomy of speech impairment. (orig.). With 4 figs., 1 tab

  2. Imaging in primary progressive aphasia

    Energy Technology Data Exchange (ETDEWEB)

    Abe, K. [Department of Neurology, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565 (Japan); Ukita, H. [Rehabilitation Service, Osaka University Hospital, Osaka (Japan); Yanagihara, T. [Department of Neurology, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565 (Japan)

    1997-08-01

    Primary progressive aphasia (PPA) presents with aphasia, with or without other minor cognitive dysfunction. We report five patients with PPA to show the correlation between their clinical signs and imaging findings. The patients can be divided into those with nonfluent (group 1) and those with fluent (group 2) aphasia. The characteristic speech impairment was bradylalia in group 1 and word amnesia in group 2. Impairment of comprehension was common but mild in both groups. On MRI, patients in group 1 showed predominantly left frontal and perisylvian atrophy with reduced uptake in the same region on single photon emission computed tomography (SPECT) using technetium-99m hexamethyl propyleneamine oxime ({sup 99m}Tc HMPAO). Patients in group 2 showed left temporal atrophy involving the superior, middle and inferior temporal gyri, hippocampus and parahippocampal gyrus on MRI and reduced uptake in the same region on SPECT. These findings correlated well with the functional anatomy of speech impairment. (orig.). With 4 figs., 1 tab.

  3. Progress in thin film techniques

    International Nuclear Information System (INIS)

    Weingarten, W.

    1996-01-01

    Progress since the last Workshop is reported on superconducting accelerating RF cavities coated with thin films. The materials investigated are Nb, Nb 3 Sn, NbN and NbTiN, the techniques applied are diffusion from the vapour phase (Nb 3 Sn, NbN), the bronze process (Nb 3 Sn), and sputter deposition on a copper substrate (Nb, NbTiN). Specially designed cavities for sample evaluation by RF methods have been developed (triaxial cavity). New experimental techniques to assess the RF amplitude dependence of the surface resistance are presented (with emphasis on niobium films sputter deposited on copper). Evidence is increasing that they are caused by magnetic flux penetration into the surface layer. (R.P.)

  4. Progress in the developing countries

    International Nuclear Information System (INIS)

    Simnad, M.

    1981-01-01

    Nuclear programmes in selective developing countries are briefly discussed. The oil rich countries of Iraq, Libya and Iran all have reactors on order. Turkey has decided to purchase a PWR from the USSR and Egypt's programme anticipates a capacity of 6600 MWe by 2000. The current projections for India are 6000 MWe by 1990 and 20,000 MWe by 2000. The progress of Pakistan, South Korea and other Asian countries are discussed. The predicted growth in reactors and population in Latin America is considered - 17 reactors presently planned for a population of 340 million and 18-57 possible additions in 2000 for an estimated population of 600 million. The role of the IAEA and experience of some Western countries in technology transfer is discussed with the ambitious Spanish nuclear power programme and the experience of Argentina in purchasing Candu reactors. (author)

  5. International Study Group Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Raubenheimer, Tor O

    2000-07-18

    The focus of the ISG work was on advancing the accelerator design and supporting technologies. This is a complex process which involves a close interaction between theoretical analysis of the collider design and R and D progress on hardware components. The sequence of efforts took place roughly in the following order: (1) Optimization of the collider parameters and definition of system and subsystem requirements, (2) Identification of design strategies and options, and (3) Development of specific technologies to achieve these requirements. Development and testing of the required components, and R and D on manufacturing techniques have been important activities of the ISG. Experiments at the major test facilities such as the ATF at KEK and ASSET at SLAC have also played a significant role in the ISG studies.

  6. High energy physics: Progress report

    International Nuclear Information System (INIS)

    Phillips, G.C.; Roberts, J.B. Jr.; Bonner, B.E.

    1987-01-01

    Analysis of data on collision of protons with targets of He, Be, C, Al, Sn, and Pb continued. A jet signal has been clearly observed from all nuclei. A collaboration has been formed for carrying out an experiment studying the photoproduced jets from nuclei and propagation of quarks and gluons through nuclear matter. The production of lambda hyperons was studied using the primary polarized beam at BNL/AGS at 13.3 and 18.5 GeV/c. The effect of the proton beam polarization on the lambda production, A/sub N/ and spin transfer have been measured. A request was approved for additional polarized proton beam at the AGS to continue measurements of the spin transfer to hyperons. Progress is reported on an initial 200 GeV/c polarized beam-polarized target experiment. A collaborative experiment was approved for the saearch for exotic/hybrid mesons. Investigations in quantum field theories, especially quantum chromodynamics, were contined

  7. Artificial sensory organs: latest progress.

    Science.gov (United States)

    Nakamura, Tatsuo; Inada, Yuji; Shigeno, Keiji

    2018-03-01

    This study introduces the latest progress on the study of artificial sensory organs, with a special emphasis on the clinical results of artificial nerves and the concept of in situ tissue engineering. Peripheral nerves have a strong potential for regeneration. An artificial nerve uses this potential to recover a damaged peripheral nerve. The polyglycolic acid collagen tube (PGA-C tube) is a bio-absorbable tube stuffed with collagen of multi-chamber structure that consists of thin collagen films. The clinical application of the PGA-C tube began in 2002 in Japan. The number of PGA-C tubes used is now beyond 300, and satisfactory results have been reported on peripheral nerve repairs. This PGA-C tube is also effective for patients suffering from neuropathic pain.

  8. Progress Towards Environmentally Friendlier Automobiles

    Science.gov (United States)

    Culver, Robert

    2002-03-01

    The United States Council for Automotive Research (USCAR), the umbrella organization of DaimlerChrysler, Ford, and General Motors, has been conducting pre-competitive research in the areas of improving fuel efficiency and reducing tailpipe emissions. One of the major collaborations is with the U.S. Government in the Partnership for a New Generation of Vehicles (PNGV). The USCAR/PNGV technology portfolio includes lightweight materials, improved conventional internal combustion engine systems, electric traction and hybridization, and fuel cells. Significant progress has been made in developing these technologies and marketing them through today’s vehicles. New product announcements of hybrids demonstrate the commitment of the industry to bring the new technologies to market. Yet, breakthroughs and innovations will be required before many of the technologies can fully realize their promise. In addition, government policies and programs will be required to promote market acceptance and ensure an infrastructure to provide new fuels.

  9. Decomposable Mandrel Project. Progress report

    International Nuclear Information System (INIS)

    Letts, S.A.; Fearon, E.; Allison, L.; Buckley, S.; Saculla, M.; Cook, R.

    1995-01-01

    We report on our progress in developing a new technology to produce both Nova and NIF scale capsules using a depolymerizable mandrel. In this technique we use poly(α-methylstyrene) (PAMS) beads or shells as mandrels which are overcoated with plasma polymer. The poly(α-methylstyrene) mandrel is then thermally depolymerized to gas phase monomer which diffuses away through the more thermally stable plasma polymer coating, leaving a hollow shell. Since our last report we have concentrated on characterization of the final shell. Starting with PAMS bead mandrels leads to distorted pyrolyzed shells because of thermally induced creep of the CH coating. We found that plasma polymer coatings on hollow shell mandrels shrink isotropically during pyrolysis and maintain sphericity. We are now concentrating our efforts on the use of microencapsulated shells to prepare targets with buried diagnostic layers or inner wall surface texture

  10. Progress report 1996-1997

    International Nuclear Information System (INIS)

    1997-01-01

    This document describes the activities of the DRFC (CEA-France) during the last 2 years. It is divided into 3 parts. In the first part experimental results concerning Tore-supra device are presented involving topics about long discharges, current generating experiments, edge plasma physics with results about the divertor and studies about MHD, turbulence and transport. The second part is dedicated to the daily operations and technological development of Tore-supra. A progress status of the CIEL project is made. The last part is devoted to the research program for the next stage and the long term. This program focuses on 5 fields: superconductive magnets, plasma facing components, negative ion sources, current generation and HF heating, and reactor studies. (A.C.)

  11. Nuclear power 1984: Progressive normalisation

    International Nuclear Information System (INIS)

    Popp, M.

    1984-01-01

    The peaceful use of nuclear power is being integrated into the overall concept of a safe long-term power supply in West Germany. The progress of normalisation is shown particularly in the takeover of all stations of the nuclear fuel circuit by the economy, with the exception of the final storage of radioactive waste, which is the responsibility of the West German Government. Normalisation also means the withdrawal of the state from financing projects after completion of the two prototypes SNR-300 and THTR-300 and the German uranium enrichment plant. The state will, however, support future research and development projects in the nuclear field. The expansion of nuclear power capacity is at present being slowed down by the state of the economy, i.e. only nuclear power projects being built are proceeding. (orig./HP) [de

  12. Responsible Canadian energy progress report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    The Canadian Association of Petroleum Producers (CAPP) represents oil and gas companies throughout Canada; its members produce over 90% of Canada's natural gas and crude oil output. The aim of the Association is to improve the economics of the Canadian upstream petroleum sector in an environmentally and socially responsible way. The aim of this Responsible Canadian Energy report is to present the performance data of CAPP's members for the year 2009. Data, trends, and performance analyses are provided throughout the document. This analysis makes it possible to determine where progress has been made and where performance improvement is necessary. It also presents success stories and best practices so that other companies can learn from them how to improve their own performance. This paper provides useful information on the performance of the upstream petroleum industry in Canada and highlights where the focus should be for further improvement in its performance.

  13. Climate economics in progress 2011

    International Nuclear Information System (INIS)

    De Perthuis, Christian; Jouvet, Pierre-Andre; Trotignon, Raphael; Simonet, Gabriela; Boutueil, Virginie

    2011-01-01

    Climate Economics in Progress offers a global overview of the present status of action on climate change. Drawing on the most recent data, it analyzes the development of carbon markets in Europe and other parts of the world. It also examines the conditions for including major players such as China and new sectors such as agriculture, forestry and transport in the fight against global warming. The book is essential reading for anyone wishing to understand current advances in climate control, which could pave the way for a new form of economic growth. The book brings together a group of researchers whose goal is to make the link between academic research on the economics of climate change and the implementation of operational tools, thereby allowing the climate issue to be integrated into the functioning of the real economy

  14. "Human potential" and progressive pedagogy

    DEFF Research Database (Denmark)

    Øland, Trine

    2012-01-01

    This article examines the cultural constructs of progressive pedagogy in Danish school pedagogy and its emerging focus on the child’s human potential from the 1920s to the 1950s. It draws on Foucault’s notion of ‘dispositifs’ and the ‘elements of history’, encircling a complex transformation......: the emergence of ‘intelligence’ and life as a biological phenomenon from the 1920s is illustrated; the emergence of ‘Black culture’, ‘Negros’ and ‘races’ from the 1930s is depicted, and the emergence of ‘national cultures’ from the 1940s – enhanced by UNESCO after World War II – is demonstrated. Although race...

  15. Progressive multifocal leukoencephalopathy: new concepts

    Directory of Open Access Journals (Sweden)

    Marco A. Lima

    2013-09-01

    Full Text Available Progressive multifocal leukoencephalopathy (PML is a demyelinating disease of the CNS caused by reactivation of JC virus (JCV in a setting of cellular immunosuppression. Originally, PML was observed in patients with advanced HIV infection, lymphoproliferative disorders and transplant recipients. However, the widespread use of HIV antiretroviral drugs and the new selective immunomodulatory and immunosuppressive medications, such as Rituximab and Natalizumab, has recently modified the epidemiology, clinical presentation and prognosis of PML. Herein, we discuss the new concepts on PML, emphasizing the recent modification in the epidemiology; the impact of new immunomodulatory treatments in the disease, PML-IRIS (Immune reconstitution inflammatory síndrome, new treatment strategies and other JCV related CNS diseases.

  16. Progress of ITER vacuum vessel

    Energy Technology Data Exchange (ETDEWEB)

    Ioki, K., E-mail: Kimihiro.Ioki@iter.org [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Bayon, A. [F4E, c/ Josep Pla, No. 2, Torres Diagonal Litoral, Edificio B3, E-08019 Barcelona (Spain); Choi, C.H.; Daly, E.; Dani, S.; Davis, J.; Giraud, B.; Gribov, Y.; Hamlyn-Harris, C.; Jun, C.; Levesy, B. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Kim, B.C. [NFRI, 52 Yeoeundong Yuseonggu, Daejeon 305-333 (Korea, Republic of); Kuzmin, E. [NTC “Sintez”, Efremov Inst., 189631 Metallostroy, St. Petersburg (Russian Federation); Le Barbier, R.; Martinez, J.-M. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Pathak, H. [ITER-India, A-29, GIDC Electronic Estate, Sector 25, Gandhinagar 382025 (India); Preble, J. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Sa, J.W. [NFRI, 52 Yeoeundong Yuseonggu, Daejeon 305-333 (Korea, Republic of); Terasawa, A.; Utin, Yu. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); and others

    2013-10-15

    Highlights: ► This covers the overall status and progress of the ITER vacuum vessel activities. ► It includes design, R and D, manufacturing and approval process of the regulators. ► The baseline design was completed and now manufacturing designs are on-going. ► R and D includes ISI, dynamic test of keys and lip-seal welding/cutting technology. ► The VV suppliers produced full-scale mock-ups and started VV manufacturing. -- Abstract: Design modifications were implemented in the vacuum vessel (VV) baseline design in 2011–2012 for finalization. The modifications are mostly due to interface components, such as support rails and feedthroughs for the in-vessel coils (IVC). Manufacturing designs are being developed at the domestic agencies (DAs) based on the baseline design. The VV support design was also finalized and tests on scale mock-ups are under preparation. Design of the in-wall shielding (IWS) has progressed, considering the assembly methods and the required tolerances. Further modifications are required to be consistent with the DAs’ manufacturing designs. Dynamic tests on the inter-modular and stub keys to support the blanket modules are being performed to measure the dynamic amplification factor (DAF). An in-service inspection (ISI) plan has been developed and R and D was launched for ISI. Conceptual design of the VV instrumentation has been developed. The VV baseline design was approved by the agreed notified body (ANB) in accordance with the French Nuclear Pressure Equipment Order procedure.

  17. Progress in nanotechnology for healthcare.

    Science.gov (United States)

    Raffa, V; Vittorio, O; Riggio, C; Cuschieri, A

    2010-06-01

    This review based on the Wickham lecture given by AC at the 2009 SMIT meeting in Sinaia outlines the progress made in nano-technology for healthcare. It describes in brief the nature of nano-materials and their unique properties which accounts for the significant research both in scientific institutions and industry for translation into new therapies embodied in the emerging field of nano-medicine. It stresses that the potential of nano-medicine to make significant inroads for more effective therapies both for life-threatening and life-disabling disorders will only be achieved by high-quality life science research. The first generation of passive nano-diagnostics based on nanoparticle contrast agents for magnetic resonance imaging is well established in clinical practice and new such contrast agents are undergoing early clinical evaluation. Likewise active (second generation) nano-therapies, exemplified by targeted control drug release systems are undergoing early clinical evaluation. The situation concerning other nano-materials such as carbon nanotubes (CNTs) and boron nitride nanotubes (BNNTs) is less advanced although considerable progress has been made on their coating for aqueous dispersion and functionalisation to enable carriage of drugs, genes and fluorescent markers. The main problem related to the clinical use of these nanotubes is that there is no consent among scientists on the fate of such nano-materials following injection or implantation in humans. Provided carbon nanotubes are manufactured to certain medical criteria (length around 1 mum, purity of 97-99% and low Fe content) they exhibit no cytotoxicity on cell cultures and demonstrate full bio-compatibility on in vivo animal studies. The results of recent experimental studies have demonstrated the potential of technologies based on CNTs for low voltage wireless electro-chemotherapy of tumours and for electro-stimulation therapies for cardiac, neurodegenerative and skeletal and visceral muscle

  18. Progress Report 2004-2005

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-11-01

    The Faculty of Electrical Engineering and Computing (FER) as a part of University of Zagreb, has its roots in the Technical Faculty Zagreb, founded in 1919, which evolved into the Faculty of Electrical Engineering in 1956 and was upgraded into the Faculty of Electrical Engineering and Computing in 1994. Due to the increasing progress and advances in electrical and electronic engineering as well as in computer science and information technologies, the Faculty has become the largest technical faculty and the leading educational and R and D institution in the fields of electrical engineering and computing in Croatia. More than 13000 graduate students, more than 1900 postgraduate students who received the Master degree and more than 540 students with PhD degree, are today's total numbers, which highlights our highly spirited activities in teaching. Additional to this number are also 3800 undergraduate students as well as about 500 graduates each year. Organised in 11 departments, the present educational staff comprises 130 professors and 200 teaching assistants and researchers operating in more than 60 laboratories and area of more than 35000 m{sup 2}. Education and research is the crucial factor determining the economic and social progress and equality of opportunity in our societies. It becomes even more so in the digital age in order to ensure life-long-learning and the emergence of new generations of creators, researchers and entrepreneurs and to empower playing an active role in the knowledge society. The experiences at the university level should be transferred to the others. We can help to do that, as a chain the global challenge. The Faculty offers a broad spectrum of services to business and industry, from research and consultancy to conference facilities, training and postgraduate recruitment. The Faculty is a leading research-led institution and undertakes research at the highest levels of international standing. The Faculty is an integral part of the

  19. Progress Report 2004-2005

    International Nuclear Information System (INIS)

    2005-11-01

    The Faculty of Electrical Engineering and Computing (FER) as a part of University of Zagreb, has its roots in the Technical Faculty Zagreb, founded in 1919, which evolved into the Faculty of Electrical Engineering in 1956 and was upgraded into the Faculty of Electrical Engineering and Computing in 1994. Due to the increasing progress and advances in electrical and electronic engineering as well as in computer science and information technologies, the Faculty has become the largest technical faculty and the leading educational and R and D institution in the fields of electrical engineering and computing in Croatia. More than 13000 graduate students, more than 1900 postgraduate students who received the Master degree and more than 540 students with PhD degree, are today's total numbers, which highlights our highly spirited activities in teaching. Additional to this number are also 3800 undergraduate students as well as about 500 graduates each year. Organised in 11 departments, the present educational staff comprises 130 professors and 200 teaching assistants and researchers operating in more than 60 laboratories and area of more than 35000 m 2 . Education and research is the crucial factor determining the economic and social progress and equality of opportunity in our societies. It becomes even more so in the digital age in order to ensure life-long-learning and the emergence of new generations of creators, researchers and entrepreneurs and to empower playing an active role in the knowledge society. The experiences at the university level should be transferred to the others. We can help to do that, as a chain the global challenge. The Faculty offers a broad spectrum of services to business and industry, from research and consultancy to conference facilities, training and postgraduate recruitment. The Faculty is a leading research-led institution and undertakes research at the highest levels of international standing. The Faculty is an integral part of the community

  20. Genetics of Progressive Supranuclear Palsy

    Directory of Open Access Journals (Sweden)

    Sun Young Im

    2015-09-01

    Full Text Available Progressive supranuclear palsy (PSP is a neurodegenerative syndrome that is clinically characterized by progressive postural instability, supranuclear gaze palsy, parkinsonism and cognitive decline. Pathologically, diagnosis of PSP is based on characteristic features, such as neurofibrillary tangles, neutrophil threads, tau-positive astrocytes and their processes in basal ganglia and brainstem, and the accumulation of 4 repeat tau protein. PSP is generally recognized as a sporadic disorder; however, understanding of genetic background of PSP has been expanding rapidly. Here we review relevant publications to outline the genetics of PSP. Although only small number of familial PSP cases have been reported, the recognition of familial PSP has been increasing. In some familial cases of clinically probable PSP, PSP pathologies were confirmed based on NINDS neuropathological diagnostic criteria. Several mutations in MAPT, the gene that causes a form of familial frontotemporal lobar degeneration with tauopathy, have been identified in both sporadic and familial PSP cases. The H1 haplotype of MAPT is a risk haplotype for PSP, and within H1, a sub-haplotype (H1c is associated with PSP. A recent genome-wide association study on autopsyproven PSP revealed additional PSP risk alleles in STX6 and EIF2AK3. Several heredodegenerative parkinsonian disorders are referred to as PSP-look-alikes because their clinical phenotype, but not their pathology, mimics PSP. Due to the fast development of genomics and bioinformatics, more genetic factors related to PSP are expected to be discovered. Undoubtedly, these studies will provide a better understanding of the pathogenesis of PSP and clues for developing therapeutic strategies.

  1. Progress of ITER vacuum vessel

    International Nuclear Information System (INIS)

    Ioki, K.; Bayon, A.; Choi, C.H.; Daly, E.; Dani, S.; Davis, J.; Giraud, B.; Gribov, Y.; Hamlyn-Harris, C.; Jun, C.; Levesy, B.; Kim, B.C.; Kuzmin, E.; Le Barbier, R.; Martinez, J.-M.; Pathak, H.; Preble, J.; Sa, J.W.; Terasawa, A.; Utin, Yu.

    2013-01-01

    Highlights: ► This covers the overall status and progress of the ITER vacuum vessel activities. ► It includes design, R and D, manufacturing and approval process of the regulators. ► The baseline design was completed and now manufacturing designs are on-going. ► R and D includes ISI, dynamic test of keys and lip-seal welding/cutting technology. ► The VV suppliers produced full-scale mock-ups and started VV manufacturing. -- Abstract: Design modifications were implemented in the vacuum vessel (VV) baseline design in 2011–2012 for finalization. The modifications are mostly due to interface components, such as support rails and feedthroughs for the in-vessel coils (IVC). Manufacturing designs are being developed at the domestic agencies (DAs) based on the baseline design. The VV support design was also finalized and tests on scale mock-ups are under preparation. Design of the in-wall shielding (IWS) has progressed, considering the assembly methods and the required tolerances. Further modifications are required to be consistent with the DAs’ manufacturing designs. Dynamic tests on the inter-modular and stub keys to support the blanket modules are being performed to measure the dynamic amplification factor (DAF). An in-service inspection (ISI) plan has been developed and R and D was launched for ISI. Conceptual design of the VV instrumentation has been developed. The VV baseline design was approved by the agreed notified body (ANB) in accordance with the French Nuclear Pressure Equipment Order procedure

  2. Primary progressive aphasia and apraxia of speech.

    Science.gov (United States)

    Jung, Youngsin; Duffy, Joseph R; Josephs, Keith A

    2013-09-01

    Primary progressive aphasia is a neurodegenerative syndrome characterized by progressive language dysfunction. The majority of primary progressive aphasia cases can be classified into three subtypes: nonfluent/agrammatic, semantic, and logopenic variants. Each variant presents with unique clinical features, and is associated with distinctive underlying pathology and neuroimaging findings. Unlike primary progressive aphasia, apraxia of speech is a disorder that involves inaccurate production of sounds secondary to impaired planning or programming of speech movements. Primary progressive apraxia of speech is a neurodegenerative form of apraxia of speech, and it should be distinguished from primary progressive aphasia given its discrete clinicopathological presentation. Recently, there have been substantial advances in our understanding of these speech and language disorders. The clinical, neuroimaging, and histopathological features of primary progressive aphasia and apraxia of speech are reviewed in this article. The distinctions among these disorders for accurate diagnosis are increasingly important from a prognostic and therapeutic standpoint. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  3. Progression from acute to chronic pancreatitis

    DEFF Research Database (Denmark)

    Nøjgaard, Camilla; Becker, Ulrik; Matzen, Peter

    2011-01-01

    Objectives: Knowledge of the natural course of acute pancreatitis (AP) and risk of progression to chronic pancreatitis (CP) is limited. The aims were to describe: (1) the incidence of progression from AP to CP, (2) prognostic factors for progression, and (3) the natural course and mortality.......1%) during follow-up; 48.2% developed from alcoholic AP, 47.0% from idiopathic AP, and 4.8% from other causes. The mortality rate for patients with progressive AP was 2.7 times higher than in patients with nonprogressive acute pancreatitis, and 5.3 to 6.5 times higher than in the background population....... In Cox regression analyses corrected for age, only smoking was of significance for the progression from AP to CP. Conclusions: Acute pancreatitis can progress to CP, not only from alcoholic but also from nonalcoholic AP. Smoking was the strongest risk factor associated with progression. The mortality...

  4. CKD Progression and Mortality among Hispanics and Non-Hispanics.

    Science.gov (United States)

    Fischer, Michael J; Hsu, Jesse Y; Lora, Claudia M; Ricardo, Ana C; Anderson, Amanda H; Bazzano, Lydia; Cuevas, Magdalena M; Hsu, Chi-Yuan; Kusek, John W; Renteria, Amada; Ojo, Akinlolu O; Raj, Dominic S; Rosas, Sylvia E; Pan, Qiang; Yaffe, Kristine; Go, Alan S; Lash, James P

    2016-11-01

    Although recommended approaches to CKD management are achieved less often in Hispanics than in non-Hispanics, whether long-term outcomes differ between these groups is unclear. In a prospective longitudinal analysis of participants enrolled into the Chronic Renal Insufficiency Cohort (CRIC) and Hispanic-CRIC Studies, we used Cox proportional hazards models to determine the association between race/ethnicity, CKD progression (50% eGFR loss or incident ESRD), incident ESRD, and all-cause mortality, and linear mixed-effects models to assess differences in eGFR slope. Among 3785 participants, 13% were Hispanic, 43% were non-Hispanic white (NHW), and 44% were non-Hispanic black (NHB). Over a median follow-up of 5.1 years for Hispanics and 6.8 years for non-Hispanics, 27.6% of all participants had CKD progression, 21.3% reached incident ESRD, and 18.3% died. Hispanics had significantly higher rates of CKD progression, incident ESRD, and mean annual decline in eGFR than did NHW (P<0.05) but not NHB. Hispanics had a mortality rate similar to that of NHW but lower than that of NHB (P<0.05). In adjusted analyses, the risk of CKD progression did not differ between Hispanics and NHW or NHB. However, among nondiabetic participants, compared with NHB, Hispanics had a lower risk of CKD progression (hazard ratio, 0.61; 95% confidence interval, 0.39 to 0.95) and incident ESRD (hazard ratio, 0.50; 95% confidence interval, 0.30 to 0.84). At higher levels of urine protein, Hispanics had a significantly lower risk of mortality than did non-Hispanics (P<0.05). Thus, important differences in CKD progression and mortality exist between Hispanics and non-Hispanics and may be affected by proteinuria and diabetes. Copyright © 2016 by the American Society of Nephrology.

  5. Progressing towards post-2012 carbon markets

    Energy Technology Data Exchange (ETDEWEB)

    Soeren Luetken, S; Holm Olsen, K

    2011-11-15

    Confronting the end of the first Kyoto Commitment period in 2012 with no agreed outcome for global cooperation on future emission reductions, there is an urgent need to look for new opportunities for public and private cooperation to drive broad-based progress in living standards and keep projected future warming below the politically agreed 2 degrees Celsius. Responding jointly to these global challenges the United Nations environmental Program (UNEP) and its UNEP Risoe Centre (URC) have in cooperation with the Global Green Growth Institute (GGGI) prepared the Perspectives 2011. The publication focuses on the role of carbon markets in contributing to low carbon development and new mechanisms for green growth, as one core area of action to address the challenges noted above. The publication explores in ten articles, how carbon markets at national, regional and global levels can be developed and up-scaled to sustain the involvement of the private sector in leveraging finance and innovative solutions to reduce greenhouse gas emissions. The titles of the ten articles are: 1) Fragmentation of international climate policy - doom or boom for carbon markets?; 2) Perspectives on the EU carbon market; 3) China carbon market; 4) The national context of U.S. state policies for a global commons problem; 5) Mind the gap - the state-of-play of Canadian greenhouse gas mitigation; 6) Role of the UN and multilateral policies in integrating an increasingly fragmented global carbon market; 7) Making CDM work for poor and rich Africa beyond 2012 - a series of dos and don'ts; 8) Voluntary market - future perspectives; 9) Sectoral approaches as a way forward for the carbon market?; 10) The Durban outcome - a post 2012 framework approach for green house gas markets. (LN)

  6. Progressing towards post-2012 carbon markets

    Energy Technology Data Exchange (ETDEWEB)

    Soeren Luetken, S.; Holm Olsen, K.

    2011-11-15

    Confronting the end of the first Kyoto Commitment period in 2012 with no agreed outcome for global cooperation on future emission reductions, there is an urgent need to look for new opportunities for public and private cooperation to drive broad-based progress in living standards and keep projected future warming below the politically agreed 2 degrees Celsius. Responding jointly to these global challenges the United Nations environmental Program (UNEP) and its UNEP Risoe Centre (URC) have in cooperation with the Global Green Growth Institute (GGGI) prepared the Perspectives 2011. The publication focuses on the role of carbon markets in contributing to low carbon development and new mechanisms for green growth, as one core area of action to address the challenges noted above. The publication explores in ten articles, how carbon markets at national, regional and global levels can be developed and up-scaled to sustain the involvement of the private sector in leveraging finance and innovative solutions to reduce greenhouse gas emissions. The titles of the ten articles are: 1) Fragmentation of international climate policy - doom or boom for carbon markets?; 2) Perspectives on the EU carbon market; 3) China carbon market; 4) The national context of U.S. state policies for a global commons problem; 5) Mind the gap - the state-of-play of Canadian greenhouse gas mitigation; 6) Role of the UN and multilateral policies in integrating an increasingly fragmented global carbon market; 7) Making CDM work for poor and rich Africa beyond 2012 - a series of dos and don'ts; 8) Voluntary market - future perspectives; 9) Sectoral approaches as a way forward for the carbon market?; 10) The Durban outcome - a post 2012 framework approach for green house gas markets. (LN)

  7. Progress and Prospects in Stretchable Electroluminescent Devices

    Directory of Open Access Journals (Sweden)

    Wang Jiangxin

    2017-03-01

    Full Text Available Stretchable electroluminescent (EL devices are a new form of mechanically deformable electronics that are gaining increasing interests and believed to be one of the essential technologies for next generation lighting and display applications. Apart from the simple bending capability in flexible EL devices, the stretchable EL devices are required to withstand larger mechanical deformations and accommodate stretching strain beyond 10%. The excellent mechanical conformability in these devices enables their applications in rigorous mechanical conditions such as flexing, twisting, stretching, and folding.The stretchable EL devices can be conformably wrapped onto arbitrary curvilinear surface and respond seamlessly to the external or internal forces, leading to unprecedented applications that cannot be addressed with conventional technologies. For example, they are in demand for wide applications in biomedical-related devices or sensors and soft interactive display systems, including activating devices for photosensitive drug, imaging apparatus for internal tissues, electronic skins, interactive input and output devices, robotics, and volumetric displays. With increasingly stringent demand on the mechanical requirements, the fabrication of stretchable EL device is encountering many challenges that are difficult to resolve. In this review, recent progresses in the stretchable EL devices are covered with a focus on the approaches that are adopted to tackle materials and process challenges in stretchable EL devices and delineate the strategies in stretchable electronics. We first introduce the emission mechanisms that have been successfully demonstrated on stretchable EL devices. Limitations and advantages of the different mechanisms for stretchable EL devices are also discussed. Representative reports are reviewed based on different structural and material strategies. Unprecedented applications that have been enabled by the stretchable EL devices are

  8. Steady progress toward a malaria vaccine.

    Science.gov (United States)

    Lyke, Kirsten E

    2017-10-01

    Great progress has been made in reducing malaria morbidity and mortality, yet the parasite continues to cause a startling 200 million infections and 500 000 deaths annually. Malaria vaccine development is pushing new boundaries by steady advancement toward a licensed product. Despite 50 years of research, the complexity of Plasmoidum falciparum confounds all attempts to eradicate the organism. This very complexity has pushed the boundaries of vaccine development to new heights, yet it remains to be seen if an affordable vaccine can provide durable and high-level protection. Novel vaccines such as RTS,S/AS01E are on the edge of licensure, but old techniques have resurged with the ability to deliver vialed, whole organism vaccines. Novel adjuvants, multistage/multiantigen approaches and transmission blocking vaccines all contribute to a multipronged battle plan to conquer malaria. Vaccines are the most cost-effective tools to control infectious diseases, yet the complexity of malaria has frustrated all attempts to develop an effective product. This review concentrates on recent advances in malaria vaccine development that lend hope that a vaccine can be produced and malaria eradicated.

  9. Progress in quantitative GPR development at CNDE

    Energy Technology Data Exchange (ETDEWEB)

    Eisenmann, David; Margetan, F. J.; Chiou, C.-P.; Roberts, Ron; Wendt, Scott [Center for Nondestructive Evaluation, Iowa State University, 1915 Scholl Road, Ames, IA 50011-3042 (United States)

    2014-02-18

    Ground penetrating radar (GPR) uses electromagnetic (EM) radiation pulses to locate and map embedded objects. Commercial GPR instruments are generally geared toward producing images showing the location and extent of buried objects, and often do not make full use of available absolute amplitude information. At the Center for Nondestructive Evaluation (CNDE) at Iowa State University efforts are underway to develop a more quantitative approach to GPR inspections in which absolute amplitudes and spectra of measured signals play a key role. Guided by analogous work in ultrasonic inspection, there are three main thrusts to the effort. These focus, respectively, on the development of tools for: (1) analyzing raw GPR data; (2) measuring the EM properties of soils and other embedding media; and (3) simulating GPR inspections. This paper reviews progress in each category. The ultimate goal of the work is to develop model-based simulation tools that can be used assess the usefulness of GPR for a given inspection scenario, to optimize inspection choices, and to determine inspection reliability.

  10. Childhood Obesity – 2010: Progress and Challenges

    Science.gov (United States)

    Han, Joan C.; Lawlor, Debbie A.; Kimm, Sue Y.S.

    2010-01-01

    Summary The worldwide prevalence of childhood obesity has increased greatly over the past 3 decades. The increasing occurrence in children of disorders, such as type 2 diabetes, is believed to be a consequence of this obesity epidemic. Much progress has been made in understanding the genetics and physiology of appetite control and from this, the elucidation of the causes of some rare obesity syndromes. However, these rare disorders have so far taught us only limited lessons on how to prevent or reverse obesity in most children. Calorie intake and activity recommendations need to be re-assessed and better quantified, on a population level, given the more sedentary life of children today. For individual treatment, the currently recommended calorie prescriptions may be too conservative given the evolving insight on the “energy gap.” Whilst quality of research in both prevention and treatment has improved, there is still a need for high-quality multi-centre trials with long-term follow-up. Meanwhile, prevention and treatment approaches that aim to increase energy expenditure and decrease intake need to continue. Most recently, the spiralling increase in obesity prevalence may be abating for children. Thus, even greater efforts need to be made on all fronts to continue this potentially exciting trend. PMID:20451244

  11. Progress in quantitative GPR development at CNDE

    Science.gov (United States)

    Eisenmann, David; Margetan, F. J.; Chiou, C.-P.; Roberts, Ron; Wendt, Scott

    2014-02-01

    Ground penetrating radar (GPR) uses electromagnetic (EM) radiation pulses to locate and map embedded objects. Commercial GPR instruments are generally geared toward producing images showing the location and extent of buried objects, and often do not make full use of available absolute amplitude information. At the Center for Nondestructive Evaluation (CNDE) at Iowa State University efforts are underway to develop a more quantitative approach to GPR inspections in which absolute amplitudes and spectra of measured signals play a key role. Guided by analogous work in ultrasonic inspection, there are three main thrusts to the effort. These focus, respectively, on the development of tools for: (1) analyzing raw GPR data; (2) measuring the EM properties of soils and other embedding media; and (3) simulating GPR inspections. This paper reviews progress in each category. The ultimate goal of the work is to develop model-based simulation tools that can be used assess the usefulness of GPR for a given inspection scenario, to optimize inspection choices, and to determine inspection reliability.

  12. Progress in quantitative GPR development at CNDE

    International Nuclear Information System (INIS)

    Eisenmann, David; Margetan, F. J.; Chiou, C.-P.; Roberts, Ron; Wendt, Scott

    2014-01-01

    Ground penetrating radar (GPR) uses electromagnetic (EM) radiation pulses to locate and map embedded objects. Commercial GPR instruments are generally geared toward producing images showing the location and extent of buried objects, and often do not make full use of available absolute amplitude information. At the Center for Nondestructive Evaluation (CNDE) at Iowa State University efforts are underway to develop a more quantitative approach to GPR inspections in which absolute amplitudes and spectra of measured signals play a key role. Guided by analogous work in ultrasonic inspection, there are three main thrusts to the effort. These focus, respectively, on the development of tools for: (1) analyzing raw GPR data; (2) measuring the EM properties of soils and other embedding media; and (3) simulating GPR inspections. This paper reviews progress in each category. The ultimate goal of the work is to develop model-based simulation tools that can be used assess the usefulness of GPR for a given inspection scenario, to optimize inspection choices, and to determine inspection reliability

  13. Recent Progress in Cryopreservation of Bovine Oocytes

    Directory of Open Access Journals (Sweden)

    In-Sul Hwang

    2014-01-01

    Full Text Available Principle of oocyte cryoinjury is first overviewed and then research history of cryopreservation using bovine oocytes is summarized for the last two decades with a few special references to recent progresses. Various types of cryodevices have been developed to accelerate the cooling rate and applied to the oocytes from large domestic species enriched with cytoplasmic lipid droplets. Two recent approaches include the qualitative improvement of IVM oocytes prior to the vitrification and the short-term recovery culture of vitrified-warmed oocytes prior to the subsequent IVF. Supplementation of L-carnitine to IVM medium of bovine oocytes has been reported to reduce the amount of cytoplasmic lipid droplets and improve the cryotolerance of the oocytes, but it is still controversial whether the positive effect of L-carnitine is reproducible. Incidence of multiple aster formation, a possible cause for low developmental potential of vitrified-warmed bovine oocytes, was inhibited by a short-term culture of the postwarm oocytes in the presence of Rho-associated coiled-coil kinase (ROCK inhibitor. Use of an antioxidant α-tocopherol, instead of the ROCK inhibitor, also supported the revivability of the postwarm bovine oocytes. Further improvements of the vitrification procedure, combined with pre- and postvitrification chemical treatment, would overcome the high sensitivity of bovine oocytes to cryopreservation.

  14. Progress on ITER remote experimentation centre

    Energy Technology Data Exchange (ETDEWEB)

    Ozeki, Takahisa, E-mail: ozeki.takahisa@jaea.go.jp [Japan Atomic Energy Agency, 2-166 Obuchi Rokkasho, Kitakami-gun, Aomori 039-3212 (Japan); Clement-Lorenzo, Susana [Fusion for Energy, Torres Diagonal Litoral, B3, 13/03, Barcelona 08019 (Spain); Nakajima, Noriyoshi [National institute for Fusion Science and Project leader of IFERC, 2-166 Obuchi, Rokkasho, Kamikita-gun, Aomori 039-3212 (Japan)

    2016-11-15

    Construction of ITER remote experimentation centre (REC) based on the broader approach (BA) activity of the joint program of Japan and Europe (EU) is progressing. In order to make the future experiments of ITER and JT-60SA effectively and efficiently implemented, development of a remote experiment system by using the Satellite Tokamak (JT-60SA) facilities was planned and the development of software for the remote experiment is ongoing, including the systems for the remote connection and the communication between the remote site and the on-site facility. The network system from REC in Rokkasho-site of Japan to the network in EU was established in collaboration with the National Institute of Informatics (NII). Effective data transfer method that is capable of fast transfer speeds in the gigabit range is investigated. Data transfer at the rate of several Gbps was successfully obtained between the institutes in Japan. The preliminary versions of the software for data analysis are developed, such as for visualization of time dependent experimental data and transport simulations, visualization of plasma boundary/equilibrium and spatial profiles of diagnostic data. The remote data access program and an integrated platform for Documentation and Experiment Management are also being developed. A remote experiment room in the Rokkasho-site in Japan was designed and the construction started. The function of REC will be tested and the total system will be demonstrated by the middle of 2017.

  15. Progress on ITER remote experimentation centre

    International Nuclear Information System (INIS)

    Ozeki, Takahisa; Clement-Lorenzo, Susana; Nakajima, Noriyoshi

    2016-01-01

    Construction of ITER remote experimentation centre (REC) based on the broader approach (BA) activity of the joint program of Japan and Europe (EU) is progressing. In order to make the future experiments of ITER and JT-60SA effectively and efficiently implemented, development of a remote experiment system by using the Satellite Tokamak (JT-60SA) facilities was planned and the development of software for the remote experiment is ongoing, including the systems for the remote connection and the communication between the remote site and the on-site facility. The network system from REC in Rokkasho-site of Japan to the network in EU was established in collaboration with the National Institute of Informatics (NII). Effective data transfer method that is capable of fast transfer speeds in the gigabit range is investigated. Data transfer at the rate of several Gbps was successfully obtained between the institutes in Japan. The preliminary versions of the software for data analysis are developed, such as for visualization of time dependent experimental data and transport simulations, visualization of plasma boundary/equilibrium and spatial profiles of diagnostic data. The remote data access program and an integrated platform for Documentation and Experiment Management are also being developed. A remote experiment room in the Rokkasho-site in Japan was designed and the construction started. The function of REC will be tested and the total system will be demonstrated by the middle of 2017.

  16. Mapping Neurodegenerative Disease Onset and Progression.

    Science.gov (United States)

    Seeley, William W

    2017-08-01

    Brain networks have been of long-standing interest to neurodegeneration researchers, including but not limited to investigators focusing on conventional prion diseases, which are known to propagate along neural pathways. Tools for human network mapping, however, remained inadequate, limiting our understanding of human brain network architecture and preventing clinical research applications. Until recently, neuropathological studies were the only viable approach to mapping disease onset and progression in humans but required large autopsy cohorts and laborious methods for whole-brain sectioning and staining. Despite important advantages, postmortem studies cannot address in vivo, physiological, or longitudinal questions and have limited potential to explore early-stage disease except for the most common disorders. Emerging in vivo network-based neuroimaging strategies have begun to address these issues, providing data that complement the neuropathological tradition. Overall, findings to date highlight several fundamental principles of neurodegenerative disease anatomy and pathogenesis, as well as some enduring mysteries. These principles and mysteries provide a road map for future research. Copyright © 2017 Cold Spring Harbor Laboratory Press; all rights reserved.

  17. Sexual harassment: Have we made any progress?

    Science.gov (United States)

    Quick, James Campbell; McFadyen, M Ann

    2017-07-01

    Sexual harassment (SH) is a continuing, chronic occupational health problem in organizations and work environments. First addressed in the Journal of Occupational Health Psychology through a 1998 Special Section on Sexual Harassment, we return to this consequential issue. If the goal is to reduce SH in organizations, and we believe that it should be, then a key question is whether we have made progress in 2 decades. The answer is mixed. Yes, there is a 28% decline in SH complaints. No, there is an increase in complaints by males. No, there has been an increase in the percentage of merit resolutions and monetary benefits. Maybe, because how do we explain the complexity of SH with emergent gay, lesbian, and transgender workforce members. One persistent problematic aspect of SH lack of agreement on definition. We address 2 of the 3 definitional approaches. We consider the broad, negative consequences for organizations and for individual victims. Harassers and aggressors destroy lives, leaving long legacies of suffering. In addition, we offer some suggestions for moving forward in science and practice, with emphasis on the role of the bystander. We conclude that SH is a preventable, if not always predictable, occupational health problem. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  18. [Progress in transgenic fish techniques and application].

    Science.gov (United States)

    Ye, Xing; Tian, Yuan-Yuan; Gao, Feng-Ying

    2011-05-01

    Transgenic technique provides a new way for fish breeding. Stable lines of growth hormone gene transfer carps, salmon and tilapia, as well as fluorescence protein gene transfer zebra fish and white cloud mountain minnow have been produced. The fast growth characteristic of GH gene transgenic fish will be of great importance to promote aquaculture production and economic efficiency. This paper summarized the progress in transgenic fish research and ecological assessments. Microinjection is still the most common used method, but often resulted in multi-site and multi-copies integration. Co-injection of transposon or meganuclease will greatly improve the efficiency of gene transfer and integration. "All fish" gene or "auto gene" should be considered to produce transgenic fish in order to eliminate misgiving on food safety and to benefit expression of the transferred gene. Environmental risk is the biggest obstacle for transgenic fish to be commercially applied. Data indicates that transgenic fish have inferior fitness compared with the traditional domestic fish. However, be-cause of the genotype-by-environment effects, it is difficult to extrapolate simple phenotypes to the complex ecological interactions that occur in nature based on the ecological consequences of the transgenic fish determined in the laboratory. It is critical to establish highly naturalized environments for acquiring reliable data that can be used to evaluate the environ-mental risk. Efficacious physical and biological containment strategies remain to be crucial approaches to ensure the safe application of transgenic fish technology.

  19. White matter disease correlates with lexical retrieval deficits in primary progressive aphasia

    Directory of Open Access Journals (Sweden)

    John P. Powers

    2013-12-01

    Full Text Available Objective: To relate fractional anisotropy changes associated with the semantic and logopenic variants of primary progressive aphasia to measures of lexical retrieval.Methods: We collected neuropsychological testing, volumetric MRI, and diffusion-weighted imaging on semantic variant primary progressive aphasia (n=11 and logopenic variant primary progressive aphasia (n=13 patients diagnosed using published criteria. We also acquired neuroimaging data on a group of demographically comparable healthy seniors (n=34. Fractional anisotropy was calculated and analyzed using a white matter tract-specific analysis approach. This approach utilizes anatomically guided data reduction to increase sensitivity and localizes results within canonically defined tracts. We used non-parametric, cluster-based statistical analysis to relate language performance to fractional anisotropy and determine regions of reduced fractional anisotropy in patients. Results: We found widespread fractional anisotropy reductions in white matter for both variants of primary progressive aphasia. Fractional anisotropy was related to both confrontation naming and category naming fluency performance in left uncinate fasciculus and corpus callosum in semantic variant primary progressive aphasia and left superior and inferior longitudinal fasciculi in logopenic variant primary progressive aphasia. Conclusions: Semantic variant primary progressive aphasia and logopenic variant primary progressive aphasia are associated with distinct disruptions of a large-scale network implicated in lexical retrieval, and the white matter disease in each phenotype may contribute to language impairments including lexical retrieval.

  20. Let s make progress together!

    Science.gov (United States)

    Adriana, Mazare; Liliana, Gheorghian

    2015-04-01

    Let's make progress together! The "Theodor Balan" Secondary School in the urban area of Suceava County in northeastern Romania is involved in several different projects. In order to extend previous successful projects with the students, parents, teachers, businesses and local government representatives in science symposiums for civic projects within the concept of sustainable development, the school is continuing to develop various successful programs. "The battle" continues both in nature and in the classrooms, in order to preserve the environment and to discover new resources. To raise awareness about the importance of existing resources even at the level of individuals there is a constant concern for keeping up to date on what already exists and is well known, but at the same time to remove "barriers" and discover new horizons and resources. Scientific activities held in our school are an effective way to educate students and the community to which they belong. In our community, we discovered sources of drinking water polluted by nitrites from fertilizers used in agriculture. In order to inform and educate people in the area, our teachers have organized several educational activities. Its purpose was: -Knowledge of the importance of water for the environment and human health. -Reducing water pollution. Students have informed their families' about sustainable development acquired at school. In this way, the school manages to educate and change people's ideas. The ways and methods of adults' learning were practiced within a Grundtvig training course "It's never too late learning to learn" in February 2014, in Florence, Italy. The GIFT 2014 was a great occasion for the teachers and students, the county's educational department and the participants at the National Colloquia of Physics to discover new materials provided at the Conference and the latest news and topics in the world of science. The theme trips at the physics laboratories of "Alexandru Ioan Cuza

  1. Heavy ion interactions of deformed nuclei. Progress report, May 1, 1984-December 31, 1984

    International Nuclear Information System (INIS)

    Oberacker, V.E.

    1984-11-01

    This progress report describes the main topics that were investigated during the reporting period: (a) a new microscopic approach to the calculation of heavy ion interaction potentials; (b) the dynamical orientation of deformed heavy nuclei near the distance of closest approach; and (c) the theory of Coulomb fission (project finished in Sept.)

  2. Safeguards Envelope Progress FY08

    International Nuclear Information System (INIS)

    Bean, Robert; Metcalf, Richard; Bevill, Aaron

    2008-01-01

    The Safeguards Envelope Project met its milestones by creating a rudimentary safeguards envelope, proving the value of the approach on a small scale, and determining the most appropriate path forward. The Idaho Chemical Processing Plant's large cache of reprocessing process monitoring data, dubbed UBER Data, was recovered and used in the analysis. A probabilistic Z test was used on a Markov Monte Carlo simulation of expected diversion data when compared with normal operating data. The data regarding a fully transient event in a tank was used to create a simple requirement, representative of a safeguards envelope, whose impact was a decrease in operating efficiency by 1.3% but an increase in material balance period of 26%. This approach is operator, state, and international safeguards friendly and should be applied to future reprocessing plants. Future requirements include tank-to-tank correlations in reprocessing facilities, detailed operations impact studies, simulation inclusion, automated optimization, advanced statistics analysis, and multi-attribute utility analysis

  3. Progress, Wealth, and Mathematics Achievement

    DEFF Research Database (Denmark)

    Valero, Paola

    2013-01-01

    I am interested in discussing the historical conditions that make it possible to formulate the idea that the mathematical qualifications of citizens in modern states is connected to the progress and economic development of nations. I interconnect apparently unrelated areas in an attempt to shed l......, H. (1899). Préface. L' Enseignement Mathématique, 1(1), 1-5. Popkewitz, T. S. (2008). Cosmopolitanism and the age of school reform: Science, education, and making society by making the child. New York: Routledge....... to the end of the 19th century. During the second half of the 19th century, mathematics teachers in different countries struggled to make mathematics part of the classic school curricula. During the second industrialization, the justification for the need for mathematics education was formulated in the first...... as a result, among others, of the growing series of comparative information on educational achievement and development. Such reports can be seen as performances of the comparative logic of Modernity that operates differential positioning, not only among individuals but also among nations, with respect to what...

  4. Scientific progress at Yucca Mountain

    International Nuclear Information System (INIS)

    Gertz, C.P.

    1990-01-01

    The US Department of Energy (DOE) is moving forward with studies to determine whether Yucca Mountain, Nevada, would be a suitable site for the nation's first high-level radioactive waste repository; however, the DOE's Congressionally mandated task of characterizing the site has been severely delayed by a lack of cooperation from the state of Nevada. The state has refused to issue the appropriate permits that must be obtained before surface disturbing studies can proceed; therefore, an extensive surface-based drilling and trenching program and construction of underground exploration facilities are on hold until pending litigation between the DOE and Nevada has been resolved. Despite this major impasse, significant scientific progress has been made, and the DOE is aggressively pursuing investigations that can be conducted without the state-issued permits. Additionally, the DOE is developing a high-quality technical and management structure as well as equipment, plans, and quality assurance procedures, so that the scientific investigation program can proceed without delay once the appropriate permits are obtained

  5. Silicon spintronics: Progress and challenges

    Energy Technology Data Exchange (ETDEWEB)

    Sverdlov, Viktor; Selberherr, Siegfried, E-mail: Selberherr@TUWien.ac.at

    2015-07-14

    Electron spin attracts much attention as an alternative to the electron charge degree of freedom for low-power reprogrammable logic and non-volatile memory applications. Silicon appears to be the perfect material for spin-driven applications. Recent progress and challenges regarding spin-based devices are reviewed. An order of magnitude enhancement of the electron spin lifetime in silicon thin films by shear strain is predicted and its impact on spin transport in SpinFETs is discussed. A relatively weak coupling between spin and effective electric field in silicon allows magnetoresistance modulation at room temperature, however, for long channel lengths. Due to tunneling magnetoresistance and spin transfer torque effects, a much stronger coupling between the spin (magnetization) orientation and charge current is achieved in magnetic tunnel junctions. Magnetic random access memory (MRAM) built on magnetic tunnel junctions is CMOS compatible and possesses all properties needed for future universal memory. Designs of spin-based non-volatile MRAM cells are presented. By means of micromagnetic simulations it is demonstrated that a substantial reduction of the switching time can be achieved. Finally, it is shown that any two arbitrary memory cells from an MRAM array can be used to perform a logic operation. Thus, an intrinsic non-volatile logic-in-memory architecture can be realized.

  6. Accelerator research studies. Progress report

    International Nuclear Information System (INIS)

    1984-06-01

    Progress is reported in both experimental studies as well as theoretical understanding of the beam transport problem. Major highlights are: (a) the completion of the first channel section with 12 periods and two matching solenoids, (b) measurements of beam transmission and emittance in this 12-lens channel, (c) extensive analytical and numerical studies of the beam transport problem in collaboration with GSI (W. Germany), (d) detailed measurements and calculations of beam propagation through one lens with spherical aberration and space charge, and (e) completion of the emittance grids at the Rutherford-Appleton Laboratory. Our main objectives in Task B of our research program are: (a) study of collective acceleration of positive ions from a localized plasma source by an intense relativistic electron beam (IREB), (b) external control of the IREB beam front by a slow-wave structure to achieve higher ion energies - the Beam Front Accelerator (BFA) concept, (c) study of ion and electron acceleration and other applications of a plasma focus device, and (d) theoretical studies in support of (a) and (b). Our research in these areas has been oriented towards obtaining an improved understanding of the physical processes at work in these experiments and, subsequently, achieving improved performance for specific potential applications

  7. Progress In Optical Memory Technology

    Science.gov (United States)

    Tsunoda, Yoshito

    1987-01-01

    More than 20 years have passed since the concept of optical memory was first proposed in 1966. Since then considerable progress has been made in this area together with the creation of completely new markets of optical memory in consumer and computer application areas. The first generation of optical memory was mainly developed with holographic recording technology in late 1960s and early 1970s. Considerable number of developments have been done in both analog and digital memory applications. Unfortunately, these technologies did not meet a chance to be a commercial product. The second generation of optical memory started at the beginning of 1970s with bit by bit recording technology. Read-only type optical memories such as video disks and compact audio disks have extensively investigated. Since laser diodes were first applied to optical video disk read out in 1976, there have been extensive developments of laser diode pick-ups for optical disk memory systems. The third generation of optical memory started in 1978 with bit by bit read/write technology using laser diodes. Developments of recording materials including both write-once and erasable have been actively pursued at several research institutes. These technologies are mainly focused on the optical memory systems for computer application. Such practical applications of optical memory technology has resulted in the creation of such new products as compact audio disks and computer file memories.

  8. Tragedy, utopia and medical progress

    Science.gov (United States)

    Fredriksen, S

    2006-01-01

    In this article, tragedy and utopia are juxtaposed, and it is proposed that the problem of “medicalisation” is better understood in a framework of tragedy than in a utopian one. In utopia, it is presupposed that there is an error behind every setback and every side effect, whereas tragedy brings to light how side effects can be the result of irreconcilable conflicts. Medicalisation is to some extent the result of such a tragic conflict. We are given power by medical progress, but are also confronted with our fallibility, thus provoking insecurity. This situation is illustrated by the sudden infant death syndrome (SIDS). Recent epidemiological investigations have shown that infants sleeping in a prone position have a 15–20 times higher risk of dying from SIDS than infants sleeping in a supine position. A simple means of preventing infant death is suggested by this discovery, but insecurity is also created. What else has been overlooked? Perhaps a draught, or wet diapers, or clothes of wool are just as dangerous as sleeping prone? Further investigations and precautions will be needed, but medicalisation prevails. PMID:16877623

  9. Progress in coherent laser radar

    Science.gov (United States)

    Vaughan, J. M.

    1986-01-01

    Considerable progress with coherent laser radar has been made over the last few years, most notably perhaps in the available range of high performance devices and components and the confidence with which systems may now be taken into the field for prolonged periods of operation. Some of this increasing maturity was evident at the 3rd Topical Meeting on Coherent Laser Radar: Technology and Applications. Topics included in discussions were: mesoscale wind fields, nocturnal valley drainage and clear air down bursts; airborne Doppler lidar studies and comparison of ground and airborne wind measurement; wind measurement over the sea for comparison with satellite borne microwave sensors; transport of wake vortices at airfield; coherent DIAL methods; a newly assembled Nd-YAG coherent lidar system; backscatter profiles in the atmosphere and wavelength dependence over the 9 to 11 micrometer region; beam propagation; rock and soil classification with an airborne 4-laser system; technology of a global wind profiling system; target calibration; ranging and imaging with coherent pulsed and CW system; signal fluctuations and speckle. Some of these activities are briefly reviewed.

  10. Progress on Variable Cycle Engines

    Science.gov (United States)

    Westmoreland, J. S.; Howlett, R. A.; Lohmann, R. P.

    1979-01-01

    Progress in the development and future requirements of the Variable Stream Control Engine (VSCE) are presented. The two most critical components of this advanced system for future supersonic transports, the high performance duct burner for thrust augmentation, and the low jet coannular nozzle were studied. Nozzle model tests substantiated the jet noise benefit associated with the unique velocity profile possible with a coannular nozzle system on a VSCE. Additional nozzle model performance tests have established high thrust efficiency levels only at takeoff and supersonic cruise for this nozzle system. An experimental program involving both isolated component and complete engine tests has been conducted for the high performance, low emissions duct burner with good results and large scale testing of these two components is being conducted using a F100 engine as the testbed for simulating the VSCE. Future work includes application of computer programs for supersonic flow fields to coannular nozzle geometries, further experimental testing with the duct burner segment rig, and the use of the Variable Cycle Engine (VCE) Testbed Program for evaluating the VSCE duct burner and coannular nozzle technologies.

  11. Rapidly Progressive Corticobasal Degeneration Syndrome

    Directory of Open Access Journals (Sweden)

    Ana Herrero Valverde

    2011-08-01

    Full Text Available Introduction: Corticobasal syndrome (CBS has a heterogeneous clinical presentation with no specific pathologic substratum. Its accurate diagnosis is a challenge for neurologists; in order to establish CBS definitively, postmortem confirmation is required. Some clinical and radiological features can help to distinguish it from other neurodegenerative conditions, such as Creutzfeldt-Jakob disease (CJD. Clinical Case: A 74-year-old woman presented with language impairment, difficulty in walking and poor attentiveness that had begun 10 days before. Other symptoms, such as asymmetrical extra-pyramidal dysfunction, limb dystonia and ‘alien limb’ phenomena, were established over the next 2 months, with rapid progression. Death occurred 3 months after symptom onset. Laboratory results were normal. Initially, imaging only showed restricted diffusion with bilateral parieto-occipital gyri involvement on DWI-MRI, with unspecific EEG changes. An autopsy was performed. Brain neuropathology confirmed sporadic CJD (sCJD. Conclusions: CBS is a heterogeneous clinical syndrome whose differential diagnosis is extensive. CJD can occasionally present with clinical characteristics resembling CBS. MRI detection of abnormalities in some sequences (FLAIR, DWI, as previously reported, has high diagnostic utility for sCJD diagnosis – especially in early stages – when other tests can still appear normal. Abnormalities on DWI sequencing may not correlate with neuropathological findings, suggesting a functional basis to explain the changes found.

  12. Progress Toward Future Runway Management

    Science.gov (United States)

    Lohr, Gary W.; Brown, Sherilyn A.; Atkins, Stephen; Eisenhawer, Stephen W.; Bott, Terrance F.; Long, Dou; Hasan, Shahab

    2011-01-01

    The runway is universally acknowledged as a constraining factor to capacity in the National Airspace System (NAS). It follows that investigation of the effective use of runways, both in terms of selection and assignment, is paramount to the efficiency of future NAS operations. The need to address runway management is not a new idea; however, as the complexities of factors affecting runway selection and usage increase, the need for effective research in this area correspondingly increases. Under the National Aeronautics and Space Administration s Airspace Systems Program, runway management is a key research area. To address a future NAS which promises to be a complex landscape of factors and competing interests among users and operators, effective runway management strategies and capabilities are required. This effort has evolved from an assessment of current practices, an understanding of research activities addressing surface and airspace operations, traffic flow management enhancements, among others. This work has yielded significant progress. Systems analysis work indicates that the value of System Oriented Runway Management tools is significantly increased in the metroplex environment over that of the single airport case. Algorithms have been developed to provide runway configuration recommendations for a single airport with multiple runways. A benefits analysis has been conducted that indicates the SORM benefits include supporting traffic growth, cost reduction as a result of system efficiency, NAS optimization from metroplex operations, fairness in aircraft operations, and rational decision making.

  13. Progress in Brucella vaccine development

    Science.gov (United States)

    YANG, Xinghong; SKYBERG, Jerod A.; CAO, Ling; CLAPP, Beata; THORNBURG, Theresa; PASCUAL, David W.

    2012-01-01

    Brucella spp. are zoonotic, facultative intracellular pathogens, which cause animal and human disease. Animal disease results in abortion of fetuses; in humans, it manifests flu-like symptoms with an undulant fever, with osteoarthritis as a common complication of infection. Antibiotic regimens for human brucellosis patients may last several months and are not always completely effective. While there are no vaccines for humans, several licensed live Brucella vaccines are available for use in livestock. The performance of these animal vaccines is dependent upon the host species, dose, and route of immunization. Newly engineered live vaccines, lacking well-defined virulence factors, retain low residual virulence, are highly protective, and may someday replace currently used animal vaccines. These also have possible human applications. Moreover, due to their enhanced safety and efficacy in animal models, subunit vaccines for brucellosis show great promise for their application in livestock and humans. This review summarizes the progress of brucellosis vaccine development and presents an overview of candidate vaccines. PMID:23730309

  14. Silicon spintronics: Progress and challenges

    International Nuclear Information System (INIS)

    Sverdlov, Viktor; Selberherr, Siegfried

    2015-01-01

    Electron spin attracts much attention as an alternative to the electron charge degree of freedom for low-power reprogrammable logic and non-volatile memory applications. Silicon appears to be the perfect material for spin-driven applications. Recent progress and challenges regarding spin-based devices are reviewed. An order of magnitude enhancement of the electron spin lifetime in silicon thin films by shear strain is predicted and its impact on spin transport in SpinFETs is discussed. A relatively weak coupling between spin and effective electric field in silicon allows magnetoresistance modulation at room temperature, however, for long channel lengths. Due to tunneling magnetoresistance and spin transfer torque effects, a much stronger coupling between the spin (magnetization) orientation and charge current is achieved in magnetic tunnel junctions. Magnetic random access memory (MRAM) built on magnetic tunnel junctions is CMOS compatible and possesses all properties needed for future universal memory. Designs of spin-based non-volatile MRAM cells are presented. By means of micromagnetic simulations it is demonstrated that a substantial reduction of the switching time can be achieved. Finally, it is shown that any two arbitrary memory cells from an MRAM array can be used to perform a logic operation. Thus, an intrinsic non-volatile logic-in-memory architecture can be realized

  15. Progress report and renewal proposal

    International Nuclear Information System (INIS)

    Signell, P.

    1982-01-01

    We have been working mainly on five inter-related subprojects: (1) derivation of the intermediate range nucleon-nucleon interaction with the new dramatically altered ππ s-wave interaction and using a new method that utilizes much shorter and simpler analytic continuation through the unphysical region that lies between the πN and ππ physical regions of the N anti N→ππ amplitude (with significantly improved accuracy for the nucleon-nucleon interaction); (2) construction of a short range phenomenological potential that, with the theoretical part mentioned above, gives a precise fit to the nucleon-nucleon data and is parameterized for easy use in nucleon calculations; (3) phase shift analyses of the world data below 400 MeV, especially the large amount of very precise data below 20 MeV and the new data near 55 MeV that have never been analyzed properly, and determining which phrases are given by theory at which energies; (4) the introduction of our K-matrix formulation of the Optimal Polynomial Expansion in order to accelerate convergence of the partial wave series at LAMPF energies; and (5) setting up of a cooperatively evaluated and verified permanent nucleon-nucleon data bank in the 0-1200 range that can be used by all nucleon-nucleon researchers (or anyone else) via Telenet dial-in and by means of a published compendium. Progress is reported

  16. Progress in hydrogen fueled busses

    International Nuclear Information System (INIS)

    Scott, P.B.; Mazaika, D.M.; Tyler, T.

    2004-01-01

    'Full text:' The Thor/ISE fuel cell bus has been in demonstration and revenue service during 2002-2003 at sites including SunLine Transit, Chula Vista Transit, Los Angeles County Metropolitan Transit Authority, and AC Transit in Oakland. By taking advantage of ISE's advanced hybrid-electric drive technology, this 30-foot bus operates with a much smaller fuel cell than those used in other buses of this class. Further, stress on the fuel cell is diminished. Based on the exceptional performance of this prototype bus, the transit agencies listed above have concluded that hybrid electric hydrogen fueled buses are attractive. Two types of hydrogen fueled hybrid electric buses will be described: - fuel cell powered, and - HICE (Hydrogen Internal Combustion Engine) This progress report will include: 1. Experience with the Thor/ISE fuel cell bus, including results from revenue service at two transit locations, 2. Design and fabrication status of the advanced fuel cell buses being built for AC Transit and SunLine Transit, 3. Design and fabrication status of the prototype HHICE (Hybrid electric Hydrogen fueled Internal Combustion Engine) bus that uses a Ford hydrogen burning engine, mated to a generator, rather than a fuel cell. Other than the engine, the drive train in the HHICE bus is nearly identical to that of a fuel cell hybrid-electric bus. Canadian participation in the HHICE bus is extensive, it is a New Flyer platform and will be winter tested in Winnipeg. (author)

  17. Peptide Vaccine: Progress and Challenges

    Directory of Open Access Journals (Sweden)

    Weidang Li

    2014-07-01

    Full Text Available Conventional vaccine strategies have been highly efficacious for several decades in reducing mortality and morbidity due to infectious diseases. The bane of conventional vaccines, such as those that include whole organisms or large proteins, appear to be the inclusion of unnecessary antigenic load that, not only contributes little to the protective immune response, but complicates the situation by inducing allergenic and/or reactogenic responses. Peptide vaccines are an attractive alternative strategy that relies on usage of short peptide fragments to engineer the induction of highly targeted immune responses, consequently avoiding allergenic and/or reactogenic sequences. Conversely, peptide vaccines used in isolation are often weakly immunogenic and require particulate carriers for delivery and adjuvanting. In this article, we discuss the specific advantages and considerations in targeted induction of immune responses by peptide vaccines and progresses in the development of such vaccines against various diseases. Additionally, we also discuss the development of particulate carrier strategies and the inherent challenges with regard to safety when combining such technologies with peptide vaccines.

  18. Progress report on Green Deals 2013; Voortgangsrapportage Green Deals 2013

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-11-15

    In the Dutch governmental coalition agreement the Green Deal approach was announced in the autumn of 2010. The focus of the Green Deals is for people and companies to develop sustainable initiatives that contribute to economic growth. The Green Deal approach started with the theme energy, but has been extended with the themes biobased economy, climate, resources, buildings, food, mobility, water and biological diversity. This progress report provides an overview of the deals that this bottom-up approach has yielded. The report also provides information on the progress of the deals and the interim results of the approach and the individual deals. Also attention is paid to how the 146 Green Deals score on innovation and entrepreneurship [Dutch] In het regeerakkoord van het kabinet is in het najaar van 2010 de Green Deal-aanpak aangekondigd. Centraal in de aanpak staat dat mensen en bedrijven zoveel mogelijk ruimte krijgen voor eigen duurzame initiatieven die bijdragen aan economische groei. De aanpak is gestart vanuit het thema energie, maar beslaat inmiddels ook de thema's biobased economy, klimaat, grondstoffen, bouw, voedsel, mobiliteit, water en biodiversiteit. Deze voortgangsrapportage geeft een overzicht van de deals die deze bottom-up aanpak heeft opgeleverd. De rapportage informeert bovendien over de voortgang van de deals en over de tussentijdse resultaten van zowel de aanpak als de afzonderlijke deals. Ook wordt gekeken hoe de 146 Green Deals scoren op innovatief vermogen en ondernemerschap.

  19. Modeling and Predicting AD Progression by Regression Analysis of Sequential Clinical Data

    KAUST Repository

    Xie, Qing

    2016-02-23

    Alzheimer\\'s Disease (AD) is currently attracting much attention in elders\\' care. As the increasing availability of massive clinical diagnosis data, especially the medical images of brain scan, it is highly significant to precisely identify and predict the potential AD\\'s progression based on the knowledge in the diagnosis data. In this paper, we follow a novel sequential learning framework to model the disease progression for AD patients\\' care. Different from the conventional approaches using only initial or static diagnosis data to model the disease progression for different durations, we design a score-involved approach and make use of the sequential diagnosis information in different disease stages to jointly simulate the disease progression. The actual clinical scores are utilized in progress to make the prediction more pertinent and reliable. We examined our approach by extensive experiments on the clinical data provided by the Alzheimer\\'s Disease Neuroimaging Initiative (ADNI). The results indicate that the proposed approach is more effective to simulate and predict the disease progression compared with the existing methods.

  20. Modeling and Predicting AD Progression by Regression Analysis of Sequential Clinical Data

    KAUST Repository

    Xie, Qing; Wang, Su; Zhu, Jia; Zhang, Xiangliang

    2016-01-01

    Alzheimer's Disease (AD) is currently attracting much attention in elders' care. As the increasing availability of massive clinical diagnosis data, especially the medical images of brain scan, it is highly significant to precisely identify and predict the potential AD's progression based on the knowledge in the diagnosis data. In this paper, we follow a novel sequential learning framework to model the disease progression for AD patients' care. Different from the conventional approaches using only initial or static diagnosis data to model the disease progression for different durations, we design a score-involved approach and make use of the sequential diagnosis information in different disease stages to jointly simulate the disease progression. The actual clinical scores are utilized in progress to make the prediction more pertinent and reliable. We examined our approach by extensive experiments on the clinical data provided by the Alzheimer's Disease Neuroimaging Initiative (ADNI). The results indicate that the proposed approach is more effective to simulate and predict the disease progression compared with the existing methods.

  1. When Progressive Disease Does Not Mean Treatment Failure: Reconsidering the Criteria for Progression

    Science.gov (United States)

    2012-01-01

    Although progression-based endpoints, such as progression-free survival, are often key clinical trial endpoints for anticancer agents, the clinical meaning of “objective progression” is much less certain. As scrutiny of progression-based endpoints in clinical trials increases, it should be remembered that the Response Evaluation Criteria In Solid Tumors (RECIST) progression criteria were not developed as a surrogate for survival. Now that progression-free survival has come to be an increasingly important trial endpoint, the criteria that define progression deserve critical evaluation to determine whether alternate definitions of progression might facilitate the development of stronger surrogate endpoints and more meaningful trial results. In this commentary, we review the genesis of the criteria for progression, highlight recent data that question their value as a marker of treatment failure, and advocate for several research strategies that could lay the groundwork for a clinically validated definition of disease progression in solid tumor oncology. PMID:22927506

  2. Female Progress and Discrimination. An Economic Perspective

    OpenAIRE

    Sandra E. Black

    2005-01-01

    In the last 20 years, women’s economic progress has been staggering; this progress is particularly startling given that this has also been a period of marked increases in income inequality overall, declining relative wages of blacks, and declining real wages of low-skilled workers. Recent work has proposed a number of possible explanations for the progress of women, including changing social norms (in part facilitated by technological/pharmaceutical advances), increasing skill acquisition, ch...

  3. Progress as Compositional Lock-Freedom

    DEFF Research Database (Denmark)

    Carbone, Marco; Dardha, Ornela; Montesi, Fabrizio

    2014-01-01

    A session-based process satisfies the progress property if its sessions never get stuck when it is executed in an adequate context. Previous work studied how to define progress by introducing the notion of catalysers, execution contexts generated from the type of a process. In this paper, we refine...... such definition to capture a more intuitive notion of context adequacy for checking progress. Interestingly, our new catalysers lead to a novel characterisation of progress in terms of the standard notion of lock-freedom. Guided by this discovery, we also develop a conservative extension of catalysers that does...

  4. Lifestyle modification and progressive renal failure.

    Science.gov (United States)

    Ritz, Eberhard; Schwenger, Vedat

    2005-08-01

    There is increasing evidence that lifestyle factors impact on the risk of developing chronic kidney disease (CKD) and the risk of progression of CKD. Equally important is the consideration that patients with CKD are more likely to die from cardiovascular disease than to reach the stage of end-stage renal failure. It is advantageous that manoeuvres that interfere with progression at the same time also reduce the risk of cardiovascular events. Lifestyle factors that aggravate progression include, among others, smoking, obesity and dietary salt intake. Alcohol consumption, according to some preliminary information, has a bimodal relationship to cardiovascular risk and progression, with moderate consumption being protective.

  5. Progression of motor symptoms in Parkinson's disease

    Institute of Scientific and Technical Information of China (English)

    Ruiping Xia; Zhi-Hong Mao

    2012-01-01

    Parkinson's disease (PD) is a chronic progressive neurodegenerative disease that is clinically manifested by a triad of cardinal motor symptoms - rigidity,bradykinesia and tremor - due to loss of dopaminergic neurons.The motor symptoms of PD become progressively worse as the disease advances.PD is also a heterogeneous disease since rigidity and bradykinesia are the major complaints in some patients whereas tremor is predominant in others.In recent years,many studies have investigated the progression of the hallmark symptoms over time,and the cardinal motor symptoms have different rates of progression,with the disease usually progressing faster in patients with rigidity and bradykinesia than in those with predominant tremor.The current treatment regime of dopamine-replacement therapy improves motor symptoms and alleviates disability.Increasing the dosage of dopaminergic medication is commonly used to combat the worsenirtg symptoms.However,the drug-induced involuntary body movements and motor comphcations can significantly contribute to overall disability.Further,none of the currently-available therapies can slow or halt the disease progression.Significant research efforts have been directed towards developing neuroprotective or disease-modifying agents that are intended to slow the progression.In this article,the most recent clinical studies investigating disease progression and current progress on the development of disease-modifying drug trials are reviewed.

  6. Progressive cerebral atrophy in neuromyelitis optica.

    Science.gov (United States)

    Warabi, Yoko; Takahashi, Toshiyuki; Isozaki, Eiji

    2015-12-01

    We report two cases of neuromyelitis optica patients with progressive cerebral atrophy. The patients exhibited characteristic clinical features, including elderly onset, secondary progressive tetraparesis and cognitive impairment, abnormally elevated CSF protein and myelin basic protein levels, and extremely highly elevated serum anti-AQP-4 antibody titer. Because neuromyelitis optica pathology cannot switch from an inflammatory phase to the degenerative phase until the terminal phase, neuromyelitis optica rarely appears as a secondary progressive clinical course caused by axonal degeneration. However, severe intrathecal inflammation and massive destruction of neuroglia could cause a secondary progressive clinical course associated with cerebral atrophy in neuromyelitis optica patients. © The Author(s), 2015.

  7. Progress toward poliomyelitis eradication in Nigeria.

    Science.gov (United States)

    Ado, J Mohammed; Etsano, Andrew; Shuaib, Faisal; Damisa, Eunice; Mkanda, Pascal; Gasasira, Alex; Banda, Richard; Korir, Charles; Johnson, Ticha; Dieng, Boubacar; Corkum, Melissa; Enemaku, Ogu; Mataruse, Noah; Ohuabunwo, Chima; Baig, Shahzad; Galway, Michael; Seaman, Vincent; Wiesen, Eric; Vertefeuille, John; Ogbuanu, Ikechukwu U; Armstrong, Gregory; Mahoney, Frank J

    2014-11-01

    Transmission of wild poliovirus (WPV) has never been interrupted in Afghanistan, Pakistan, and Nigeria. Since 2003, infections with WPV of Nigerian origin have been detected in 25 polio-free countries. In 2012, the Nigerian government created an emergency operations center and implemented a national emergency action plan to eradicate polio. The 2013 revision of this plan prioritized (1) improving the quality of supplemental immunization activities (SIAs), (2) implementing strategies to reach underserved populations, (3) adopting special approaches in security-compromised areas, (4) improving outbreak response, (5) enhancing routine immunization and activities implemented between SIAs, and (6) strengthening surveillance. This report summarizes implementation of these activities during a period of unprecedented insecurity and violence, including the killing of health workers and the onset of a state of emergency in the northeast zone. This report reviews management strategies, innovations, trends in case counts, vaccination and social mobilization activities, and surveillance and monitoring data to assess progress in polio eradication in Nigeria. Nigeria has made significant improvements in the management of polio eradication initiative (pei) activities with marked improvement in the quality of SIAs, as measured by lot quality assurance sampling (LQAS). Comparing results from February 2012 with results from December 2013, the proportion of local government areas (LGAs) conducting LQAS in the 11 high-risk states at the ≥90% pass/fail threshold increased from 7% to 42%, and the proportion at the 80%-89% threshold increased from 9% to 30%. During January-December 2013, 53 polio cases were reported from 26 LGAs in 9 states in Nigeria, compared with 122 cases reported from 13 states in 2012. No cases of WPV type 3 infection have been reported since November 2012. In 2013, no polio cases due to any poliovirus type were detected in the northwest sanctuaries of Nigeria. In

  8. Progress report 1998/1999

    International Nuclear Information System (INIS)

    2000-01-01

    Among the significant technological achievements of 1998-99, we will note in particular the manufacture of a lower hybrid antenna. This has large size and is shielded from the plasma by side protection incorporating the same technology that is used in the limiter of the CIEL project. This antenna was tested successfully in the autumn 1999; its capacity is 4 MW steady state. Substantial progress was achieved in testing the 118 GHz gyrotrons that are intended to deliver 400 kW with a pulse length of 210 seconds. Pulses lasting some 15.5 seconds were obtained on load during the summer 1999 and were limited only by the performance of the load and by out-gassing. At these pulse lengths, the parameters of the tube are already quasi-stationary. The tests will begin again in the Spring of 2000 with a more suitable load. The very first tests on plasma took place in the Autumn of 1999 showing a strong absorption of the waves by the plasma. Work in the field of the high frequency heating systems focused on problems of local power deposition close to the antenna. This problem is exacerbated, both at the lower hybrid and at the ion cyclotron frequencies, by the need to carry out long pulse discharges. Modelling the localised effects that have been observed contributes to the evolution of the design of both types of antenna and holds out the prospect of fully-validated solutions for the 'next step'. Using the technology developed for the CIEL project in the field of the high heat flux components also made it possible to implement side protections for the antennas that can withstand the temperature rise related to these local effects. Studies in various modes of heating or current drive were continued, in order to explore the corresponding scenarios but also to make progress in modelling the phenomena of wave propagation and absorption. In the field of ion cyclotron waves, the implementation of 3 He minority heating made it possible to identify the conversion of the fast wave

  9. Electronics a systems approach

    CERN Document Server

    Storey, Neil

    2017-01-01

    Electronics plays a central role in our everyday lives. It is at the heart of almost all of today's essential technology, from mobile phones to computers and from cars to power stations. As such, all engineers, scientists and technologists need to have a fundamental understanding of this exciting subject, and for many this will just be the beginning. Now in its sixth edition, Electronics: A Systems Approach provides an outstanding introduction to this fast-moving and important field. Comprehensively revised and updated to cover the latest developments in the world of electronics, the text continues to use Neil Storey's established and well-respected systems approach. It introduces the basic concepts first before progressing to a more advanced analysis, enabling you to contextualise what a system is designed to achieve before tackling the intricacies of designing or analysing its various components with confidence. This book is accompanied by a website which contains over 100 video tutorials to help explain ke...

  10. Thermal ratcheting and progressive buckling

    International Nuclear Information System (INIS)

    Lebey, J.; Brouard, D.; Roche, R.L.

    1983-01-01

    Pure elastic buckling is not a frequent mode of failure and plastic deformations often occurs before buckling - like instability does. Elastic-plastic buckling is very difficult to analyse. The most important difficulty is the material modeling. In the elastic plastic buckling phenomena, small modifications of the material constitutive equation used are of great influence on the final result. When buckling cannot occurs, it is well known that distortion due to applied loads is greatly amplified when there is also some cyclic straining (like thermal stresses). This effect is called ratcheting - and thermal ratcheting when caused by cyclic thermal transients. As cyclic thermal stresses can be applied in addition of load able to cause buckling failure of a component, the question arise of the effect of cyclic thermal stresses on the critical buckling load. The aim of the work presented here is to answer that question: 'Is the critical buckling load reduced when cyclic straining is added'. It seems sensible to avoid premature computation based only on arbitrary assumptions and to prefer obtaining a sound experimental basis for analysis. Sufficient experimental knowledge is needed in order to check the validity of the material modeling (and imperfections) used in analysis. Experimental tests on buckling of compressed columns subjected to cyclic straining have been performed. These experiments are described and results are given. The most important result is cyclic straining reduces the critical buckling load. It appears that distortion can be increasing progressively during cyclic straining and that buckling can happen at last at compressive loads too small to cause buckling in the absence of cyclic straining. (orig./RW)

  11. Giant hydronephrosis mimicking progressive malignancy

    Science.gov (United States)

    Schrader, Andres Jan; Anderer, Georgia; von Knobloch, Rolf; Heidenreich, Axel; Hofmann, Rainer

    2003-01-01

    Background Cases of giant hydronephroses are rare and usually contain no more than 1–2 litres of fluid in the collecting system. We report a remarkable case of giant hydronephrosis mimicking a progressive malignant abdominal tumour. Case presentation A 78-year-old cachectic woman presented with an enormous abdominal tumour, which, according to the patient, had slowly increased in diameter. Medical history was unremarkable except for a hysterectomy >30 years before. A CT scan revealed a giant cystic tumour filling almost the entire abdominal cavity. It was analysed by two independent radiologists who suspected a tumour originating from the right kidney and additionally a cystic ovarian neoplasm. Subsequently, a diagnostic and therapeutic laparotomy was performed: the tumour presented as a cystic, 35 × 30 × 25 cm expansive structure adhesive to adjacent organs without definite signs of invasive growth. The right renal hilar vessels could finally be identified at its basis. After extirpation another tumourous structure emerged in the pelvis originating from the genital organs and was also resected. The histopathological examination revealed a >15 kg hydronephrotic right kidney, lacking hardly any residual renal cortex parenchyma. The second specimen was identified as an ovary with regressive changes and a large partially calcified cyst. There was no evidence of malignant growth. Conclusion Although both clinical symptoms and the enormous size of the tumour indicated malignant growth, it turned out to be a giant hydronephrosis. Presumably, a chronic obstruction of the distal ureter had caused this extraordinary hydronephrosis. As demonstrated in our case, an accurate diagnosis of giant hydronephrosis remains challenging due to the atrophy of the renal parenchyma associated with chronic obstruction. Therefore, any abdominal cystic mass even in the absence of other evident pathologies should include the differential diagnosis of a possible hydronephrosis. Diagnostic

  12. Progress report 1999-2000

    International Nuclear Information System (INIS)

    2000-01-01

    This document presents the activities of the CENBG for the 1999 and 2000 years. The activities are arranged into 7 topics: 1) astro-particles, 2) high spins and big deformations, 3) fundamental interactions, 4) exotic nuclei, 5) the down end of the nuclear fuel cycle and ADS (accelerator driven system), 6) theoretical physics and 7) at the interface between physics and biology. Among a lot of achievements relevant to INIS we can note: -) the investigation of 2 new modes of decay: the bound internal conversion and the Pauli forbidden bound internal conversion, -) the progress made on the Nemo-3 experiment whose purpose is the possibility of detecting the neutrinoless double beta decay from the kinematics specificities of the 2 electrons released, -) the first observation of the doubly-magic nucleus Ni 48 , -) the beta delayed proton and gamma -ray spectroscopy of Mg 21 and Si 25 nuclei, -) the identification of the fundamental state of Li 10 , -) the measurement of the masses of nuclei close to N = Z line in the region A = 80, -) the measurement of the beta decay of Ga 62 (T = 116 ms), and concerning ADS technology: -) the neutron capture cross-section of Th 232 has been measured in the energy range from 60 keV to 2 MeV, -) the determination of neutron induced fission cross-section of Pa 233 in the fast neutron energy range from 0.5 to 10 MeV, and -) the measurement of isotopic distributions for all residual elements from Ti to Pb produced in the reaction 1 A.GeV Pb 208 on proton. (A.C.)

  13. Visible Nulling Coronagraph Progress Report

    Science.gov (United States)

    Lyon, R. G.; Clampin, M.; Woodruff, R. A.; Vasudevan, G.; Thompson, P.; Petrone, P.; Madison, T.; Rizzo, M.; Melnick, G.; Tolls, V.

    2010-10-01

    We report on recent laboratory results with the NASA Goddard Space Flight Center Visible Nulling Coronagraph (VNC) testbed. We have achieved focal plane contrasts of 108 and approaching 109 at inner working angles of 2 λ/D and 4 λ/D, respectively. Results were obtained with a broadband source and 40 nm filter centered on 630 nm. A null control breadboard (NCB) was also developed to assess and quantify MEMS based deformable mirror technology (DM), and to develop and assess closed-loop null control algorithms. We have demonstrated closed-loop performance at 27 Hz.

  14. Safeguards Envelope Progress FY08

    Energy Technology Data Exchange (ETDEWEB)

    Robert Bean; Richard Metcalf; Aaron Bevill

    2008-09-01

    The Safeguards Envelope Project met its milestones by creating a rudimentary safeguards envelope, proving the value of the approach on a small scale, and determining the most appropriate path forward. The Idaho Chemical Processing Plant’s large cache of reprocessing process monitoring data, dubbed UBER Data, was recovered and used in the analysis. A probabilistic Z test was used on a Markov Monte Carlo simulation of expected diversion data when compared with normal operating data. The data regarding a fully transient event in a tank was used to create a simple requirement, representative of a safeguards envelope, whose impact was a decrease in operating efficiency by 1.3% but an increase in material balance period of 26%. This approach is operator, state, and international safeguards friendly and should be applied to future reprocessing plants. Future requirements include tank-to-tank correlations in reprocessing facilities, detailed operations impact studies, simulation inclusion, automated optimization, advanced statistics analysis, and multi-attribute utility analysis.

  15. Progress in Rectal Cancer Treatment

    Science.gov (United States)

    Ceelen, Wim P.

    2012-01-01

    The dramatic improvement in local control of rectal cancer observed during the last decades is to be attributed to attention to surgical technique and to the introduction of neoadjuvant therapy regimens. Nevertheless, systemic relapse remains frequent and is currently insufficiently addressed. Intensification of neoadjuvant therapy by incorporating chemotherapy with or without targeted agents before the start of (chemo)radiation or during the waiting period to surgery may present an opportunity to improve overall survival. An increasing number of patients can nowadays undergo sphincter preserving surgery. In selected patients, local excision or even a “wait and see” approach may be feasible following active neoadjuvant therapy. Molecular and genetic biomarkers as well as innovative imaging techniques may in the future allow better selection of patients for this treatment option. Controversy persists concerning the selection of patients for adjuvant chemotherapy and/or targeted therapy after neoadjuvant regimens. The currently available evidence suggests that in complete pathological responders long-term outcome is excellent and adjuvant therapy may be omitted. The results of ongoing trials will help to establish the ideal tailored approach in resectable rectal cancer. PMID:22970381

  16. ZERODUR: progress in CTE characterization

    Science.gov (United States)

    Jedamzik, Ralf; Kunisch, Clemens; Westerhoff, Thomas

    2013-09-01

    In 2010, SCHOTT introduced a method for the modeling of the thermal expansion behavior of ZERODUR® under arbitrary temperature profiles for an optimized production of material for the upcoming Extremely Large Telescope (ELT) projects. In 2012 a new product was introduced based on this method called ZERODUR® TAILORED. ZERODUR® TAILORED provides an evolution in the specification of the absolute Coefficient of Thermal Expansion (CTE) value by including the individual customer requirements in this process. This paper presents examples showing the benefit of an application oriented approach in the design of specifications using ZERODUR®. Additionally it will be shown how the modeling approach has advanced during the last years to improve the prediction accuracy on long time scales. ZERODUR® is known not only for its lowest CTE but also for its excellent CTE homogeneity as shown in the past for disc shaped blanks typical for telescope mirror substrates. Additionally this paper presents recent results of CTE homogeneity measurements in the single digit ppb/K range for a rectangular cast plate proving that the excellent CTE homogeneity is independent of the production format.

  17. Design progress of the ITER vacuum vessel sectors and port structures

    International Nuclear Information System (INIS)

    Utin, Yu.; Ioki, K.; Alekseev, A.; Bachmann, Ch.; Cho, S.; Chuyanov, V.; Jones, L.; Kuzmin, E.; Morimoto, M.; Nakahira, M.; Sannazzaro, G.

    2007-01-01

    Recent progress of the ITER vacuum vessel (VV) design is presented. As the ITER construction phase approaches, the VV design has been improved and developed in more detail with the focus on better performance, improved manufacture and reduced cost. Based on achievements of manufacturing studies, design improvement of the typical VV Sector (no. 1) has been nearly finalized. Design improvement of other sectors is in progress-in particular, of the VV Sectors no. 2 and no. 3 which interface with tangential ports for the neutral beam (NB) injection. For all sectors, the concept for the in-wall shielding has progressed and developed in more detail. The design progress of the VV sectors has been accompanied by the progress of the port structures. In particular, design of the NB ports was advanced with the focus on the beam-facing components to handle the heat input of the neutral beams. Structural analyses have been performed to validate all design improvements

  18. Model-based setup assistant for progressive tools

    Science.gov (United States)

    Springer, Robert; Gräler, Manuel; Homberg, Werner; Henke, Christian; Trächtler, Ansgar

    2018-05-01

    In the field of production systems, globalization and technological progress lead to increasing requirements regarding part quality, delivery time and costs. Hence, today's production is challenged much more than a few years ago: it has to be very flexible and produce economically small batch sizes to satisfy consumer's demands and avoid unnecessary stock. Furthermore, a trend towards increasing functional integration continues to lead to an ongoing miniaturization of sheet metal components. In the industry of electric connectivity for example, the miniaturized connectors are manufactured by progressive tools, which are usually used for very large batches. These tools are installed in mechanical presses and then set up by a technician, who has to manually adjust a wide range of punch-bending operations. Disturbances like material thickness, temperatures, lubrication or tool wear complicate the setup procedure. In prospect of the increasing demand of production flexibility, this time-consuming process has to be handled more and more often. In this paper, a new approach for a model-based setup assistant is proposed as a solution, which is exemplarily applied in combination with a progressive tool. First, progressive tools, more specifically, their setup process is described and based on that, the challenges are pointed out. As a result, a systematic process to set up the machines is introduced. Following, the process is investigated with an FE-Analysis regarding the effects of the disturbances. In the next step, design of experiments is used to systematically develop a regression model of the system's behaviour. This model is integrated within an optimization in order to calculate optimal machine parameters and the following necessary adjustment of the progressive tool due to the disturbances. Finally, the assistant is tested in a production environment and the results are discussed.

  19. Comparison of Individual Performance in Intelligence Tests WAIS III and RPM (Raven's Progressive Matrices)

    OpenAIRE

    Petrů, Vít

    2017-01-01

    This thesis deals with replacement of performative scale of Wechsler Adult Intelligence Scale (3rd revision) through Raven's Standard Progressive Matrices and Advanced Progressive Matrices. In the theoretical part introduces the concepts of intelligence, approaches to its exploration and intelligence tests. The theoretical part is also devoted to the description of the used methods and presents an overview of the research on a similar theme as this work. In the empirical part of the thesis is...

  20. Tracking the Progress of English Language Learners

    Science.gov (United States)

    Murphy, Audrey F.

    2009-01-01

    Educators need to document progress for English language learners, and the best structures to put into place in order to record their growth. Beginning with the stages of language proficiency, student progress can be tracked through the use of a baseline in all four language strands and the creation of rubrics to monitor performance. Language…

  1. Progressive taxation, income inequality, and happiness.

    Science.gov (United States)

    Oishi, Shigehiro; Kushlev, Kostadin; Schimmack, Ulrich

    2018-01-01

    Income inequality has become one of the more widely debated social issues today. The current article explores the role of progressive taxation in income inequality and happiness. Using historical data in the United States from 1962 to 2014, we found that income inequality was substantially smaller in years when the income tax was more progressive (i.e., a higher tax rate for higher income brackets), even when controlling for variables like stock market performance and unemployment rate. Time lag analyses further showed that higher progressive taxation predicted increasingly lower income inequality up to 5 years later. Data from the General Social Survey (1972-2014; N = 59,599) with U.S. residents (hereafter referred to as "Americans") showed that during years with higher progressive taxation rates, less wealthy Americans-those in the lowest 40% of the income distribution-tended to be happier, whereas the richest 20% were not significantly less happy. Mediational analyses confirmed that the association of progressive taxation with the happiness of less wealthy Americans can be explained by lower income inequality in years with higher progressive taxation. A separate sample of Americans polled online (N = 373) correctly predicted the positive association between progressive taxation and the happiness of poorer Americans but incorrectly expected a strong negative association between progressive taxation and the happiness of richer Americans. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  2. Efficient progressive taxes and education subsidies

    NARCIS (Netherlands)

    van Ewijk, C.; Tang, P.J.G.

    2001-01-01

    Progressive income taxes moderate wage demands by trade unions and thereby reduce unemployment, but alsothey reduce incentives to acquire skills and lower productivity of workers. The optimal response of the governmentto this dilemma is to choose a system of progressive taxes and to (partly)

  3. Assessment of a progressive electricity tax

    International Nuclear Information System (INIS)

    2000-01-01

    Progressive electricity tax implies that the tax rate increases with consumption so that the tax paid per kWh consumed increases when the consumption increases beyond a certain level. This elucidation discusses principal and practical aspects of such a tax. It is advised against the establishment of a progressive electricity tax. The objections are of principal, economical and administrative character

  4. SuperB Progress Report: Detector

    International Nuclear Information System (INIS)

    Grauges, E.; Donvito, G.; Spinoso, V.; Manghisoni, M.; Re, V.; Traversi, G.; Eigen, G.; Fehlker, D.; Helleve, L.; Cheng, C.; Chivukula, A.; Doll, D.; Echenard, B.; Hitlin, D.; Ongmongkolkul, P.; Porter, F.; Rakitin, A.; Thomas, M.; Zhu, R.; Tatishvili, G.; Andreassen, R.; Fabby, C.; Meadows, B.; Simpson, A.; Sokoloff, M.; Tomko, K.; Fella, A.; Andreotti, M.; Baldini, W.; Calabrese, R.; Carassiti, V.; Cibinetto, G.; Cotta Ramusino, A.; Gianoli, A.; Luppi, E.; Munerato, M.; Santoro, V.; Tomassetti, L.; Stoker, D.; Bezshyyko, O.; Dolinska, G.; Arnaud, N.; Beigbeder, C.; Bogard, F.; Breton, D.; Burmistrov, L.; Charlet, D.; Maalmi, J.; Perez Perez, L.; Puill, V.; Stocchi, A.; Tocut, V.; Wallon, S.; Wormser, G.; Brown, D.

    2012-01-01

    This report describes the present status of the detector design for SuperB. It is one of four separate progress reports that, taken collectively, describe progress made on the SuperB Project since the publication of the SuperB Conceptual Design Report in 2007 and the Proceedings of SuperB Workshop VI in Valencia in 2008.

  5. Theoretical progress at CNDC theory group

    International Nuclear Information System (INIS)

    Lu Zhongdao

    1993-01-01

    In 1992, CNDC (Chinese Nuclear Data Center) theory group has made progress in model study, code making and data calculations for low energy nuclear reaction, intermediate and high energy nuclear reaction. It has also made progress in parameter library establishment. The brief explanations are presented

  6. Progressive supranuclear palsy syndrome induced by clebopride.

    Science.gov (United States)

    Campdelacreu, Jaume; Kumru, Hatice; Tolosa, Eduard; Valls-Solé, Josep; Benabarre, Antoni

    2004-04-01

    We report on a patient who presented with a progressive supranuclear palsy (PSP) syndrome while receiving clebopride (CLB), a prokinetic drug with central antidopaminergic properties. The clinical and neurophysiological signs progressively disappeared after CLB withdrawal. To our knowledge, this is the first published PSP-like syndrome attributable to an antidopaminergic drug. Copyright 2003 Movement Disorder Society

  7. Home Environmental Factors Influencing Performance and Progress ...

    African Journals Online (AJOL)

    Our findings support other studies which found that parents' educational level and income level have a bearing on school progress and performance. Contrary to most research findings mother tongue instruction did not eme1rge as an important explanatory factor on school progress and performance, however; home ...

  8. Construal operations of the English progressive construction

    DEFF Research Database (Denmark)

    Jensen, Kim Ebensgaard

    2011-01-01

    present paper provides an overview of construal operations that are likely to be at play in the construction of the aspectual and actional meaning components of the progressive construction. The discussion also involves instances of the progressive construction, which display low semantic compatibility...

  9. SuperB Progress Report: Detector

    Energy Technology Data Exchange (ETDEWEB)

    Grauges, E.; /Barcelona U., ECM; Donvito, G.; Spinoso, V.; /INFN, Bari /Bari U.; Manghisoni, M.; Re, V.; Traversi, G.; /INFN, Pavia /Bergamo U., Ingengneria Dept.; Eigen, G.; Fehlker, D.; Helleve, L.; /Bergen U.; Carbone, A.; Di Sipio, R.; Gabrielli, A.; Galli, D.; Giorgi, F.; Marconi, U.; Perazzini, S.; Sbarra, C.; Vagnoni, V.; Valentinetti, S.; Villa, M.; Zoccoli, A.; /INFN, Bologna /Bologna U. /Caltech /Carleton U. /Cincinnati U. /INFN, CNAF /INFN, Ferrara /Ferrara U. /UC, Irvine /Taras Shevchenko U. /Orsay, LAL /LBL, Berkeley /UC, Berkeley /Frascati /INFN, Legnaro /Orsay, IPN /Maryland U. /McGill U. /INFN, Milan /Milan U. /INFN, Naples /Naples U. /Novosibirsk, IYF /INFN, Padua /Padua U. /INFN, Pavia /Pavia U. /INFN, Perugia /Perugia U. /INFN, Perugia /Caltech /INFN, Pisa /Pisa U. /Pisa, Scuola Normale Superiore /PNL, Richland /Queen Mary, U. of London /Rutherford /INFN, Rome /Rome U. /INFN, Rome2 /Rome U.,Tor Vergata /INFN, Rome3 /Rome III U. /SLAC /Tel Aviv U. /INFN, Turin /Turin U. /INFN, Padua /Trento U. /INFN, Trieste /Trieste U. /TRIUMF /British Columbia U. /Montreal U. /Victoria U.

    2012-02-14

    This report describes the present status of the detector design for SuperB. It is one of four separate progress reports that, taken collectively, describe progress made on the SuperB Project since the publication of the SuperB Conceptual Design Report in 2007 and the Proceedings of SuperB Workshop VI in Valencia in 2008.

  10. SuperB Progress Reports Accelerator

    CERN Document Server

    Biagini, Maria Enrica; Boscolo, M; Buonomo, B; Demma, T; Drago, A; Esposito, M; Guiducci, S; Mazzitelli, G; Pellegrino, L; Preger, M A; Raimondi, P; Ricci, R; Rotundo, U; Sanelli, C; Serio, M; Stella, A; Tomassini, S; Zobov, M; Bertsche, K; Brachman, A; Cai, Y; Chao, A; Chesnut, R; Donald, M.H; Field, C; Fisher, A; Kharakh, D; Krasnykh, A; Moffeit, K; Nosochkov, Y; Pivi, M; Seeman, J; Sullivan, M.K; Weathersby, S; Weidemann, A; Weisend, J; Wienands, U; Wittmer, W; Woods, M; Yocky, G; Bogomiagkov, A; Koop, I; Levichev, E; Nikitin, S; Okunev, I; Piminov, P; Sinyatkin, S; Shatilov, D; Vobly, P; Bosi, F; Liuzzo, S; Paoloni, E; Bonis, J; Chehab, R; Le Meur, G; Lepercq, P; Letellier-Cohen, F; Mercier, B; Poirier, F; Prevost, C; Rimbault, C; Touze, F; Variola, A; Bolzon, B; Brunetti, L; Jeremie, A; Baylac, M; Bourrion, O; De Conto, J M; Gomez, Y; Meot, F; Monseu, N; Tourres, D; Vescovi, C; Chanci, A; Napoly, O; Barber, D P; Bettoni, S; Quatraro, D

    2010-01-01

    This report details the present status of the Accelerator design for the SuperB Project. It is one of four separate progress reports that, taken collectively, describe progress made on the SuperB Project since the publication of the SuperB Conceptual Design Report in 2007 and the Proceedings of SuperB Workshop VI in Valencia in 2008.

  11. Progress at LAMPF: Clinton P. Anderson Meson Physics Facility. Progress report, January-June 1981

    International Nuclear Information System (INIS)

    Allred, J.C.

    1981-09-01

    Progress at LAMPF is the semiannual progress report of the MP Division of the Los Alamos National Laboratory. The report includes brief reports on research done at LAMPF by researchers from other institutions and Los Alamos divisions

  12. Progress at LAMPF: Clinton P. Anderson Meson Physics Facility. Progress report, July-December 1980

    International Nuclear Information System (INIS)

    Allred, J.C.

    1981-03-01

    Progress at LAMPF is the semiannual progress report of the MP Division of the Los Alamos National Laboratory. The report also includes brief reports on research done at LAMPF by researchers from other institutions and Los Alamos divisions

  13. Progress at LAMPF: Clinton P. Anderson Meson Physics Facility. Progress report, January-June 1981

    Energy Technology Data Exchange (ETDEWEB)

    Allred, J.C. (ed.)

    1981-09-01

    Progress at LAMPF is the semiannual progress report of the MP Division of the Los Alamos National Laboratory. The report includes brief reports on research done at LAMPF by researchers from other institutions and Los Alamos divisions.

  14. Progress on DART code optimization

    International Nuclear Information System (INIS)

    Taboada, Horacio; Solis, Diego; Rest, Jeffrey

    1999-01-01

    This work consists about the progress made on the design and development of a new optimized version of DART code (DART-P), a mechanistic computer model for the performance calculation and assessment of aluminum dispersion fuel. It is part of a collaboration agreement between CNEA and ANL in the area of Low Enriched Uranium Advanced Fuels. It is held by the Implementation Arrangement for Technical Exchange and Cooperation in the Area of Peaceful Uses of Nuclear Energy, signed on October 16, 1997 between US DOE and the National Atomic Energy Commission of the Argentine Republic. DART optimization is a biannual program; it is operative since February 8, 1999 and has the following goals: 1. Design and develop a new DART calculation kernel for implementation within a parallel processing architecture. 2. Design and develop new user-friendly I/O routines to be resident on Personal Computer (PC)/WorkStation (WS) platform. 2.1. The new input interface will be designed and developed by means of a Visual interface, able to guide the user in the construction of the problem to be analyzed with the aid of a new database (described in item 3, below). The new I/O interface will include input data check controls in order to avoid corrupted input data. 2.2. The new output interface will be designed and developed by means of graphical tools, able to translate numeric data output into 'on line' graphic information. 3. Design and develop a new irradiated materials database, to be resident on PC/WS platform, so as to facilitate the analysis of the behavior of different fuel and meat compositions with DART-P. Currently, a different version of DART is used for oxide, silicide, and advanced alloy fuels. 4. Develop rigorous general inspection algorithms in order to provide valuable DART-P benchmarks. 5. Design and develop new models, such as superplasticity, elastoplastic feedback, improved models for the calculation of fuel deformation and the evolution of the fuel microstructure for

  15. Progress in understanding conversion disorder

    Science.gov (United States)

    Allin, Matthew; Streeruwitz, Anna; Curtis, Vivienne

    2005-01-01

    Conversion disorder has a history that may reach back into antiquity, and it continues to present a clinical challenge to both psychiatrists and neurologists. This article reviews the current state of knowledge surrounding the prevalence, etiology, and neurobiology of conversion disorder. There have been improvements in the accuracy of diagnosis that are possibly related to improved technologies such as neuroimaging. Once the diagnosis is made, it is important to develop a therapeutic alliance between the patient and the medical team, and where comorbid psychiatric diagnoses have been made, these need to be adequately treated. While there have been no formal trials of medication or psychoanalytic treatments in this disorder, case reports suggest that a combination of antidepressants, psychotherapy, and a multidisciplinary approach to rehabilitation may be beneficial. PMID:18568070

  16. [Riboflavin UVA crosslinking in progressive keratoconus].

    Science.gov (United States)

    Maier, P; Reinhard, T

    2017-06-01

    In patients with keratoconus, a progressive, ectatic disease of the cornea, the shape of the cornea is continuously changing leading to a reduction in visual acuity by progressive myopia and more and more (irregular) astigmatism. The symptomatic treatment consists of the prescription of glasses or special gas-permeable rigid contact lenses. Corneal tomography is generally used for diagnosis. After initial diagnosis of keratoconus, regular tomographic follow-ups should be performed. If clinically significant progression is found and confirmed by repeated measurements, riboflavin UVA collagen crosslinking should be offered to the patients. The aim of riboflavin UVA collagen crosslinking is to halt the progression of the disease to avoid further complications. The therapeutic principle is a combined effect of the photosensitizer riboflavin and UVA light. This stiffening effect of the corneal tissue halts the progression of keratoconus. The efficacy of this treatment has been demonstrated in various randomized, controlled trials.

  17. Heavy quarkonium: progress, puzzles, and opportunities

    Energy Technology Data Exchange (ETDEWEB)

    Brambilla, N; Heltsley, B K; Vogt, R; Bodwin, G T; Eichten, E; Frawley, A D; Meyer, A B; Mitchell, R E; Papdimitriou, V; Petreczky, P; Petrov, A A; Robbe, P; Vairo, A; Andronic, A; Arnaldi, R; Artoisenet, P; Bali, G; Bertolin, A; Bettoni, D; Brodzicka, J; Bruno, G E; Caldwell, A; Catmore, J; Chang, C -H; Chao, K -T; Chudakov, E; Cortese, P; Crochet, P; Drutskoy, A; Ellwanger, U; Faccioli, P; Gabareen Mokhtar, A; Garcia i Tormo, X; Hanhart, C; Harris, F A; Kaplan, D M; Klein, S R; Kowalski, H; Lansberg, J -P; Levichev, E; Lombardo, V; Loureno, C; Maltoni, F; Mocsy, A; Mussa, R; Navarra, F S; Negrini, M; Nielsen, M; Olsen, S L; Pakhlov, P; Pakhlova, G; Peters, K; Polosa, A D; Qian, W; Qiu, J -W; Rong, G; Sanchis-Lozano, M A; Scomparin, E; Senger, P; Simon, F; Stracka, S; Sumino, Y; Voloshin, M; Weiss, C; Wohri, H K; Yuan, C -Z

    2011-02-01

    A golden age for heavy quarkonium physics dawned a decade ago, initiated by the confluence of exciting advances in quantum chromodynamics (QCD) and an explosion of related experimental activity. The early years of this period were chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in 2004, which presented a comprehensive review of the status of the field at that time and provided specific recommendations for further progress. However, the broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles could only be partially anticipated. Since the release of the YR, the BESII program concluded only to give birth to BESIII; the $B$-factories and CLEO-c flourished; quarkonium production and polarization measurements at HERA, JLab, and the Tevatron matured; and heavy-ion collisions at RHIC have opened a window on the deconfinement regime. All these experiments leave legacies of quality, precision, and unsolved mysteries for quarkonium physics, and therefore beg for continuing investigations. The plethora of newly-found quarkonium-like states unleashed a flood of theoretical investigations into new forms of matter such as quark-gluon hybrids, mesonic molecules, and tetraquarks. Measurements of the spectroscopy, decays, production, and in-medium behavior of c\\bar{c}, b\\bar{b}, and b\\bar{c} bound states have been shown to validate some theoretical approaches to QCD and highlight lack of quantitative success for others. The intriguing details of quarkonium suppression in heavy-ion collisions that have emerged from RHIC have elevated the importance of separating hot- and cold-nuclear-matter effects in quark-gluon plasma studies. This review systematically addresses all these matters and concludes by prioritizing directions for ongoing and future efforts.

  18. Edge Simulation Laboratory Progress and Plans

    International Nuclear Information System (INIS)

    Cohen, R

    2007-01-01

    The Edge Simulation Laboratory (ESL) is a project to develop a gyrokinetic code for MFE edge plasmas based on continuum (Eulerian) techniques. ESL is a base-program activity of OFES, with an allied algorithm research activity funded by the OASCR base math program. ESL OFES funds directly support about 0.8 FTE of career staff at LLNL, a postdoc and a small fraction of an FTE at GA, and a graduate student at UCSD. In addition the allied OASCR program funds about 1/2 FTE each in the computations directorates at LBNL and LLNL. OFES ESL funding for LLNL and UCSD began in fall 2005, while funding for GA and the math team began about a year ago. ESL's continuum approach is a complement to the PIC-based methods of the CPES Project, and was selected (1) because of concerns about noise issues associated with PIC in the high-density-contrast environment of the edge pedestal, (2) to be able to exploit advanced numerical methods developed for fluid codes, and (3) to build upon the successes of core continuum gyrokinetic codes such as GYRO, GS2 and GENE. The ESL project presently has three components: TEMPEST, a full-f, full-geometry (single-null divertor, or arbitrary-shape closed flux surfaces) code in E, μ (energy, magnetic-moment) coordinates; EGK, a simple-geometry rapid-prototype code, presently of; and the math component, which is developing and implementing algorithms for a next-generation code. Progress would be accelerated if we could find funding for a fourth, computer science, component, which would develop software infrastructure, provide user support, and address needs for data handing and analysis. We summarize the status and plans for the three funded activities

  19. Progress report on Green Deals 2012; Voortgangsrapportage Green Deals 2012

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-10-15

    In the Dutch governmental coalition agreement the Green Deal approach was announced in the autumn of 2010. The focus of the Green Deals is for people and companies to develop sustainable initiatives that contribute to economic growth. This progress report provides an overview of the deals that this bottom-up approach has yielded. The report also provides information on the progress of the deals and the interim results of the approach and the individual deals. Also attention is paid to how the 131 Green Deals score on innovation and entrepreneurship [Dutch] In het regeerakkoord van het kabinet is in het najaar van 2010 de Green Deal-aanpak aangekondigd. Centraal in de aanpak staat dat mensen en bedrijven zoveel mogelijk ruimte krijgen voor eigen duurzame initiatieven die bijdragen aan economische groei. Deze voortgangsrapportage geeft een overzicht van de deals die deze bottom-up aanpak heeft opgeleverd. De rapportage informeert bovendien over de voortgang van de deals en over de tussentijdse resultaten van zowel de aanpak als de afzonderlijke deals. Ook wordt gekeken hoe de 131 Green Deals scoren op innovatief vermogen en ondernemerschap.

  20. Assessing progress in the development of safety culture

    International Nuclear Information System (INIS)

    Rotaru, I.; Ghita, S.; Biro, L.

    2002-01-01

    This paper is focussed on the organizational culture and learning processes required for the implementation of all aspects of safety culture. There is no prescriptive formula for improving safety culture. However, some common characteristics and practices are emerging that can be adopted by organizations in order to make progress. The paper refers to some approaches that have been successful in a number of countries. The experience of the international nuclear industry in the development and improvement of safety culture could be extended and found useful in other nuclear activities, irrespective of scale. The examples given of specific practice cover a wide range of activities including analysis of events, the regulatory approach on safety culture, employee participation and safety performance measures. Many of these practices may be relevant to smaller organizations and could contribute to improving safety culture, whatever the size of the organization. The most effective approach is to pursue a range of practices that can be mutually supportive in the development of a progressive safety culture, supported by professional standards, organizational and management commitment. Some guidance is also given on the assessment of safety culture and on the detection of a weakening safety culture. Few suggestions for accelerating the safety culture development and improvement process are also provided. (author)

  1. Understanding stress in the healthy animal - potential paths for progress.

    Science.gov (United States)

    Romero, L Michael; Platts, Steven H; Schoech, Stephan J; Wada, Haruka; Crespi, Erica; Martin, Lynn B; Buck, C Loren

    2015-01-01

    Although stress is usually associated with disease, the physiological and behavioral responses to stressors are critical mechanisms of resilience for healthy organisms. A recent workshop comprised of researchers who study healthy humans and both free-living and captive non-human animals identified a number of key roadblocks that are impeding progress in understanding how stress responses integrate into the normal physiology of an animal. These include the lack of: (1) an unambiguous definition of a stress phenotype; (2) a robust biomarker, or suite of biomarkers, to indicate that phenotype; (3) theoretical and quantitative models to predict how humans and other animals will react to stressors; (4) a comprehensive understanding of how individual variability in stress responses arise and (5) an understanding of the transitions between acute and chronic stress responses. Collectively, these deficiencies impair our ability to both assess the physiological status of individuals and develop procedures and techniques to reverse the effects elicited by chronic stress before they become pathological. Workshop participants also identified a number of potential approaches to facilitate progress on these problems. They include: (1) increased use of mathematical models to provide quantitative predictions; (2) use of network theory to expose emergent properties not predicted from traditional approaches; (3) development and deployment of improved sensor technology that will allow long-term, dynamic, non-invasive, multi-factor measurements of suites of stress mediators and (4) the recruitment of scientists with diverse skill sets, such as engineers, bioinformaticians, etc.; and (5) the training of young scientists in the multidisciplinary study of stress. Incorporating these approaches in new research should reinvigorate the study of stress and stimulate progress in understanding both how healthy humans cope with stressors and how other animals, including free-living animals, cope

  2. Studies of particle interactions in bubble chamber, spark chambers and counter experiments: Task P. Annual progress report

    International Nuclear Information System (INIS)

    Jones, L.M.; Holloway, L.; O'Halloran, T.A. Jr.; Simmons, R.O.

    1983-07-01

    Our current work reflects the general aim of this task, which is to calculate phenomenological theories of interest to present experiments. Recently, this has emphasized the jet calculus approach to properties of quark and gluon jets. Progress is reviewed

  3. Progress in corneal wound healing

    Science.gov (United States)

    Ljubimov, Alexander V.; Saghizadeh, Mehrnoosh

    2015-01-01

    Corneal wound healing is a complex process involving cell death, migration, proliferation, differentiation, and extracellular matrix remodeling. Many similarities are observed in the healing processes of corneal epithelial, stromal and endothelial cells, as well as cell-specific differences. Corneal epithelial healing largely depends on limbal stem cells and remodeling of the basement membrane. During stromal healing, keratocytes get transformed to motile and contractile myofibroblasts largely due to activation of transforming growth factor-β system. Endothelial cells heal mostly by migration and spreading, with cell proliferation playing a secondary role. In the last decade, many aspects of wound healing process in different parts of the cornea have been elucidated, and some new therapeutic approaches have emerged. The concept of limbal stem cells received rigorous experimental corroboration, with new markers uncovered and new treatment options including gene and microRNA therapy tested in experimental systems. Transplantation of limbal stem cell-enriched cultures for efficient re-epithelialization in stem cell deficiency and corneal injuries has become reality in clinical setting. Mediators and course of events during stromal healing have been detailed, and new treatment regimens including gene (decorin) and stem cell therapy for excessive healing have been designed. This is a very important advance given the popularity of various refractive surgeries entailing stromal wound healing. Successful surgical ways of replacing the diseased endothelium have been clinically tested, and new approaches to accelerate endothelial healing and suppress endothelial-mesenchymal transformation have been proposed including Rho kinase (ROCK) inhibitor eye drops and gene therapy to activate TGF-β inhibitor SMAD7. Promising new technologies with potential for corneal wound healing manipulation including microRNA, induced pluripotent stem cells to generate corneal epithelium, and

  4. Progress in wall turbulence 2 understanding and modelling

    CERN Document Server

    Jimenez, Javier; Marusic, Ivan

    2016-01-01

    This is the proceedings of the ERCOFTAC Workshop on Progress in Wall Turbulence: Understanding and Modelling, that was held in Lille, France from June 18 to 20, 2014. The workshop brought together world specialists of near wall turbulence and stimulated exchanges between them around up-to-date theories, experiments, simulations and numerical models. This book contains a coherent collection of recent results on near wall turbulence including theory, new experiments, DNS, and modeling with RANS, LES.The fact that both physical understanding and modeling by different approaches are addressed by the best specialists in a single workshop is original.

  5. Progress Report of CEN, France

    Energy Technology Data Exchange (ETDEWEB)

    Blachot, J. [Centre and Etudes Nucleaires de Grenoble, Grenoble (France)

    2013-08-15

    This paper presents the NUBASE2012 evaluation that contains the recommended values for nuclear and decay properties of nuclides in their ground and excited isomeric (T1=2{sub 1}00 ns) states. All nuclides for which some experimental information is known are considered. NUBASE2012 covers all up to date experimental data published in primary (journal articles) and secondary (mainly laboratory reports and conference proceedings) references, together with the corresponding bibliographical information. During the development of NUBASE2012, the data available in the 'Evaluated Nuclear Structure Data File' (ENSDF) database were consulted, and critically assessed of their validity and completeness. Furthermore, a large amount of new and somewhat older experimental results that were missing in ENSDF were compiled, evaluated and included in NUBASE2012. The atomic mass values were taken from the 'Atomic Mass Evaluation' (AME2012, second and third parts of the present issue). In cases where no experimental data were available for a particular nuclide, trends in the behaviour of specific properties in neighbouring nuclei (TNN) were examined. This approach allowed us to estimate, whenever possible, values for a range of properties, which are labeled in NUBASE2012 as 'non-experimental'. Evaluation procedures and policies that were used during the development of this database are presented, together with a detailed table of recommended values and their uncertainties. (author)

  6. Accelerating the pace of progress.

    Science.gov (United States)

    Chinery-hesse, M

    1995-01-01

    During the past 20 years, the proportion of women in paid employment has increased significantly. Yet women still do not have equal opportunity or receive equal treatment in the workplace. Under these conditions, society loses because it does not completely utilize all its human resources toward sustainable development. All levels of preparation for the Fourth World Conference on Women, scheduled for September 1995 in Beijing, have allowed participants to review the current social status of women. Globalization of the economy, technological transformation, and restructuring of the labor market pose difficult problems and emerging challenges for women: feminization of poverty, increasing instability of women's work, continued inequality in the sharing of family responsibilities, and inadequacy of social infrastructure to allow women both to work and to attend to their family's needs. Working women's rights continue to be neglected. The International Labor Organization's (ILO) 75 years of experience suggest that a comprehensive integrated approach and participation of all relevant actors are needed to address gender inequality in the workplace. ILO has proposed such a strategy.

  7. Progress in tropical isotope dendroclimatology

    Science.gov (United States)

    Evans, M. N.; Schrag, D. P.; Poussart, P. F.; Anchukaitis, K. J.

    2005-12-01

    The terrestrial tropics remain an important gap in the growing high resolution proxy network used to characterize the mean state and variability of the hydrological cycle. Here we review early efforts to develop a new class of proxy paleorainfall/humidity indicators using intraseasonal to interannual-resolution stable isotope data from tropical trees. The approach invokes a recently published model of oxygen isotopic composition of alpha-cellulose, rapid methods for cellulose extraction from raw wood, and continuous flow isotope ratio mass spectrometry to develop proxy chronological, rainfall and growth rate estimates from tropical trees, even those lacking annual rings. Isotopically-derived age models may be confirmed for modern intervals using trees of known age, radiocarbon measurements, direct measurements of tree diameter, and time series replication. Studies are now underway at a number of laboratories on samples from Costa Rica, northwestern coastal Peru, Indonesia, Thailand, New Guinea, Paraguay, Brazil, India, and the South American Altiplano. Improved sample extraction chemistry and online pyrolysis techniques should increase sample throughput, precision, and time series replication. Statistical calibration together with simple forward modeling based on the well-observed modern period can provide for objective interpretation of the data. Ultimately, replicated data series with well-defined uncertainties can be entered into multiproxy efforts to define aspects of tropical hydrological variability associated with ENSO, the meridional overturning circulation, and the monsoon systems.

  8. Optimal tax progressivity in imperfect labour markets

    DEFF Research Database (Denmark)

    Sørensen, Peter Birch

    1999-01-01

    that there may be an optimal degree of tax progressivity where the marginal welfare gain from reduced involuntary unemployment is just offset by the marginal welfare loss from lower productivity. This paper sets up four different models of an imperfect labour market in order to identify the degree of tax......All modern labour market theories capable of explaining involuntary unemployment as an equilibrium phenomenon imply that increased income tax progressivity reduces unemployment, but they also imply that higher progressivity tends to reduce work effort and labour productivity. This suggests...

  9. Tunneling progress on the Yucca Mountain Project

    International Nuclear Information System (INIS)

    Hansmire, W.H.; Munzer, R.J.

    1996-01-01

    The current status of tunneling progress on the Yucca Mountain Project (YMP) is presented in this paper. The Exploratory Studies Facility (ESF), a key part of the YMP, has been long in development and construction is ongoing. This is a progress report on the tunneling aspects of the ESF as of January 1, 1996. For purposes of discussion in this summary, the tunneling has progressed in four general phases. The paper describes: tunneling in jointed rock under low stress; tunneling through the Bow Ridge Fault and soft rock; tunneling through the Imbricate Fault Zone; and Tunneling into the candidate repository formation

  10. Progress on KMRR fuel fabrication

    International Nuclear Information System (INIS)

    Kuk, I.H.; Lee, J.B.; Rhee, C.K.; Kim, K.W.

    1991-01-01

    In order to increase the practical applicability of powder heat-treatment in KMRR fuel fabrication, efforts were made to reduce the critical size. Primary U 3 Si 2 particle size was reviewed in terms of cooling rate. Temperature dependence of peritectoid reaction was reviewed as well. (1) Cooling rate of U 3 Si molten alloy was calculated by ADINA program. In practice, particle size of the primary U 3 Si 2 varies radially. U 3 Si 2 size increases as it goes deeper from the surface. As cooling rate increases, primary U 3 Si 2 size decreases. (2) Peritectoid reaction occurs in two unique groups of temperature; one is below 790 C where β-U and U 3 Si 2 reaction occurs, and the other above 790 C where γ-U and U 3 Si 2 reaction occurs. 780 C is most completely reacting temperature in β-U region, and 810 C is so in γ-U region. Reaction is completed more perfectly in γ-U region than in β-U region. 810 C is found to be the optimized heat-treatment temperature, but it is desirable not to approach to 790 C in heat-treatment. (3) The critical powder size in powder heat-treatment is dependent on the primary U 3 Si 2 particle size. The smaller the primary U 3 Si 2 particle size, the smaller the critical particle size of the powder. At present, the primary U 3 Si 2 particle size can be reduced to 3∝5 μm at 4∝5 mm deep from surface in Cu mold. This may be reduced further by rapid solidification process. (orig.)

  11. Development and progress of the South African uranium enrichment project

    International Nuclear Information System (INIS)

    Roux, A.J.A.; Grant, W.L.; Barbour, R.A.; Loubser, R.S.; Wannenburg, J.J.

    1977-01-01

    The earlier development of the project is briefly reviewed, and some of the salient features of the South African process are touched upon. Development of the separation element in the last 18 months is discussed, as well as further work on the helikon cascade process. A brief description of the helikon cascade operation is given by means of diagrams. Because of time limitations, the complete helikon theory is not presented, but only some examples shown. Experimental work done to verify the helikon concept, as well as theoretical treatment, is presented. A brief report of the progress made on the experimental module of 6 t/a separative work capacity is given. This module, known as Mini-Z, is well advanced and details of its features and construction are shown. A short discussion of progress on the full-scale prototype module, known as Proto-Z, is next presented. The flexibility of such a design to fit a wide range of cascade sizes is considered, as well as cost implications of various approaches to design. Apart from progress on the development of the commercial plant, a brief review is given of the present state of the pilot plant at Valindaba. Some of the information obtained is mentioned. In conclusion, some information is given in regard to further planning and other work on the commercial plant at present being undertaken. Projected operation of the plant and some nuclear fuel service aspects are touched on

  12. Posttraumatic Progressive Vertebral Hemangioma Induced by a Fracture

    Science.gov (United States)

    Unal, Emre; Toktas, Zafer Orkun; Aker, Fugen Vardar; Akakın, Akın; Kilic, Türker

    2017-01-01

    The authors present an extremely rare case of an aggressive and progressive vertebral capillary hemangioma of the lumbar spine secondary to a trauma. A 40-year-old man who complained of back and leg pain due to a hemangioma of L1 that had begun a year after the fracture of the same vertebra was subsequently operated on. Due to the profuse bleeding, only a subtotal removal was possible. Histopathological diagnosis of the lesion revealed a capillary hemangioma. Postoperative control MRI taken at eight months showed that the lesion and destruction of the L1 vertebra were progressive. A second embolization procedure was performed and this time the hemangioma was totally removed via an anterior approach and corpectomy. Fusion was achieved by Th12-L2 graft and plaque. In the fourteenth year of follow-up, he was symptom-free and radiologically clear of this lesion. We propose that progressive hemangioma is extremely rare and that its cure is possible by total surgical removal of the lesion. This case is the second extradural capillary hemangioma secondary to spinal trauma ever to have been documented in English literature. The emergence of a hemangioma in a fractured vertebra suggests that its pathogenesis can be related to the deviation of the angiogenetic pathways from the normal healing process. PMID:28713608

  13. Learning to cooperate is essential for progress in physics

    Science.gov (United States)

    Dickau, Jonathan J.

    2012-06-01

    At the 10th Frontiers of Fundamental Physics symposium, Gerard't Hooft stated that, for some of the advances we hope to see in Physics during the future, there must be a great deal of cooperation between physicists from different disciplines, as well as mathematicians, programmers, technologists, and others. This requires us to evolve a new mindset; however, as so much of our past progress has come out of a fiercely competitive process - especially since a critical review of our ideas about reality remains essential to making clear progress and checking our progress. We must also address the fact that some frameworks appear incompatible, as with relativity and quantum mechanics, whose unification remains distant despite years of attempts to find a quantum gravity theory. I explore the idea that playful exploration, using both left-brained and right-brained approaches to learning, allows us to resolve conflicting ideas by taking advantage of innate human developmental and learning strategies and brain structure. It may thus foster the kind of interdisciplinary cooperation we are hoping to see.

  14. Infrared colloidal quantum dots for photovoltaics: fundamentals and recent progress

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Jiang [Department of Materials Science and Engineering, University of Toronto, 184 College Street, Toronto, Ontario M5S 3E4 (Canada); Sargent, Edward H. [Department of Electrical and Computer Engineering, University of Toronto, 10 King' s College Road, Toronto, Ontario M5S 3G4 (Canada)

    2011-01-04

    Colloidal quantum dots (CQDs) are solution-processed semiconductors of interest in low-cost photovoltaics. Tuning of the bandgap of CQD films via the quantum size effect enables customization of solar cells' absorption profile to match the sun's broad visible- and infrared-containing spectrum reaching the earth. Here we review recent progress in the realization of low-cost, efficient solar cells based on CQDs. We focus in particular on CQD materials and approaches that provide both infrared and visible-wavelength solar power conversion CQD photovoltaics now exceed 5% solar power conversion efficiency, achieved by the introduction of a new architecture, the depleted-heterojunction CQD solar cell, that jointly maximizes current, voltage, and fill factor. CQD solar cells have also seen major progress in materials processing for stability, recently achieving extended operating lifetimes in an air ambient. We summarize progress both in device operation and also in gaining new insights into materials properties and processing - including new electrical contact materials and deposition techniques, as well as CQD synthesis, surface treatments, film-forming technologies - that underpin these rapid advances. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  15. Environmental triggers in IBD: a review of progress and evidence.

    Science.gov (United States)

    Ananthakrishnan, Ashwin N; Bernstein, Charles N; Iliopoulos, Dimitrios; Macpherson, Andrew; Neurath, Markus F; Ali, Raja A Raja; Vavricka, Stephan R; Fiocchi, Claudio

    2018-01-01

    A number of environmental factors have been associated with the development of IBD. Alteration of the gut microbiota, or dysbiosis, is closely linked to initiation or progression of IBD, but whether dysbiosis is a primary or secondary event is unclear. Nevertheless, early-life events such as birth, breastfeeding and exposure to antibiotics, as well as later childhood events, are considered potential risk factors for IBD. Air pollution, a consequence of the progressive contamination of the environment by countless compounds, is another factor associated with IBD, as particulate matter or other components can alter the host's mucosal defences and trigger immune responses. Hypoxia associated with high altitude is also a factor under investigation as a potential new trigger of IBD flares. A key issue is how to translate environmental factors into mechanisms of IBD, and systems biology is increasingly recognized as a strategic tool to unravel the molecular alterations leading to IBD. Environmental factors add a substantial level of complexity to the understanding of IBD pathogenesis but also promote the fundamental notion that complex diseases such as IBD require complex therapies that go well beyond the current single-agent treatment approach. This Review describes the current conceptualization, evidence, progress and direction surrounding the association of environmental factors with IBD.

  16. Infrared Colloidal Quantum Dots for Photovoltaics: Fundamentals and Recent Progress

    KAUST Repository

    Tang, Jiang

    2010-09-14

    Colloidal quantum dots (CQDs) are solution-processed semiconductors of interest in low-cost photovoltaics. Tuning of the bandgap of CQD films via the quantum size effect enables customization of solar cells\\' absorption profile to match the sun\\'s broad visible- and infrared-containing spectrum reaching the earth. Here we review recent progress in the realization of low-cost, efficient solar cells based on CQDs. We focus in particular on CQD materials and approaches that provide both infrared and visible-wavelength solar power conversion CQD photovoltaics now exceed 5% solar power conversion efficiency, achieved by the introduction of a new architecture, the depleted-heterojunction CQD solar cell, that jointly maximizes current, voltage, and fill factor. CQD solar cells have also seen major progress in materials processing for stability, recently achieving extended operating lifetimes in an air ambient. We summarize progress both in device operation and also in gaining new insights into materials properties and processing - including new electrical contact materials and deposition techniques, as well as CQD synthesis, surface treatments, film-forming technologies - that underpin these rapid advances. Infrared colloidal quantum dots that absorb most of the solar radiation enable potential efficient and low-cost photovoltaic devices. Careful optimization of quantum dot passivation and device configuration leads to solar cells with AM1.5G efficiency as high as 5.1% Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Ubiquitous Health in Korea: Progress, Barriers, and Prospects

    Science.gov (United States)

    Lee, Yountae

    2012-01-01

    Objectives Korea has one of the most advanced information technology (IT) infrastructures in the world, and the application of IT in health systems is rapidly progressing from computerization to information systems, ubiquitous systems, and smart systems. This study aims to analyze Korean environments in regards to the development of their u-Health industry and propose directions for u-Healthcare services based on this analysis. Methods This paper reviews the background, progress history, and current status of u-Health in Korea, and suggests strategies for the u-Health industry based on an analysis of its barriers and obstacles. Results When u-Health was introduced to Koreans, their policies and approaches focused mainly on environmental factors, yet these efforts have not progressed further to impact the u-Healthcare service industry itself. To develop the u-Healthcare industry, four points need to be considered: the development and support of the practical service model, institutional support, support of core technology and industry, and the institutionalization of health management service. Conclusions Korea is at a strategic point to start building u-Healthcare service delivery models. u-Healthcare is a healthcare service that provides added value through u-Health environments. By identifying critical success factors in u-Healthcare, we can strengthen the u-Health industry and implement policies to coordinate our efforts in the process of value chains to which we belong. PMID:23346474

  18. Discontinuing disease-modifying therapy in progressive multiple sclerosis: can we stop what we have started?

    LENUS (Irish Health Repository)

    Lonergan, Roisin

    2012-02-01

    Disease-modifying therapy is ineffective in disabled patients (Expanded Disability Status Scale [EDSS] > 6.5) with secondary progressive multiple sclerosis (MS) without relapses, or in primary progressive MS. Many patients with secondary progressive MS who initially had relapsing MS continue to use disease-modifying therapies. The enormous associated costs are a burden to health services. Regular assessment is recommended to guide discontinuation of disease-modifying therapies when no longer beneficial, but this is unavailable to many patients, particularly in rural areas. The objectives of this study are as follows: 1. To observe use of disease-modifying therapies in patients with progressive multiple sclerosis and EDSS > 6.5. 2. To examine approaches used by a group of international MS experts to stopping-disease modifying therapies in patients with secondary progressive MS without relapses. During an epidemiological study in three regions of Ireland (southeast Dublin city, and Wexford and Donegal Counties), we recorded details of disease-modifying therapies in patients with progressive MS and EDSS > 6.5. An e-questionnaire was sent to 26 neurologists with expert knowledge of MS, asking them to share their approach to stopping disease-modifying therapies in patients with secondary progressive MS. Three hundred and thirty-six patients were studied: 88 from southeast Dublin, 99 from Wexford and 149 from Donegal. Forty-four had EDSS > 6.5: 12 were still using disease-modifying therapies. Of the surveyed neurologists, 15 made efforts to stop disease-modifying therapies in progressive multiple sclerosis, but most did not insist. A significant proportion (12 of 44 patients with progressive MS and EDSS > 6.5) was considered to be receiving therapy without benefit. Eleven of the 12 were from rural counties, reflecting poorer access to neurology services. The costs of disease-modifying therapies in this group (>170,000 euro yearly) could be re-directed towards development

  19. Prostate Cancer Treatment | Cancer Trends Progress Report

    Science.gov (United States)

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

  20. Prostate Cancer Screening | Cancer Trends Progress Report

    Science.gov (United States)

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.