WorldWideScience

Sample records for non-random distribution supports

  1. Links between fear of humans, stress and survival support a non-random distribution of birds among urban and rural habitats.

    Science.gov (United States)

    Rebolo-Ifrán, Natalia; Carrete, Martina; Sanz-Aguilar, Ana; Rodríguez-Martínez, Sol; Cabezas, Sonia; Marchant, Tracy A; Bortolotti, Gary R; Tella, José L

    2015-09-08

    Urban endocrine ecology aims to understand how organisms cope with new sources of stress and maintain allostatic load to thrive in an increasingly urbanized world. Recent research efforts have yielded controversial results based on short-term measures of stress, without exploring its fitness effects. We measured feather corticosterone (CORTf, reflecting the duration and amplitude of glucocorticoid secretion over several weeks) and subsequent annual survival in urban and rural burrowing owls. This species shows high individual consistency in fear of humans (i.e., flight initiation distance, FID), allowing us to hypothesize that individuals distribute among habitats according to their tolerance to human disturbance. FIDs were shorter in urban than in rural birds, but CORTf levels did not differ, nor were correlated to FIDs. Survival was twice as high in urban as in rural birds and links with CORTf varied between habitats: while a quadratic relationship supports stabilizing selection in urban birds, high predation rates may have masked CORTf-survival relationship in rural ones. These results evidence that urban life does not constitute an additional source of stress for urban individuals, as shown by their near identical CORTf values compared with rural conspecifics supporting the non-random distribution of individuals among habitats according to their behavioural phenotypes.

  2. Discovery of Non-random Spatial Distribution of Impacts in the Stardust Cometary Collector

    Energy Technology Data Exchange (ETDEWEB)

    Westphal, A J; Bastien, R K; Borg, J; Bridges, J; Brownlee, D E; Burchell, M J; Cheng, A F; Clark, B C; Djouadi, Z; Floss, C; Franchi, I; Gainsforth, Z; Graham, G; Green, S F; Heck, P R; Horanyi, M; Hoppe, P; Horz, F P; Huth, J; Kearsley, A; Leroux, H; Marhas, K; Nakamura-Messenger, K; Sandford, S A; See, T H; Stadermann, F J; Teslich, N E; Tsitrin, S; Warren, J L; Wozniakiewicz, P J; Zolensky, M E

    2007-04-06

    We report the discovery that impacts in the Stardust cometary collector are not distributed randomly in the collecting media, but appear to be clustered on scales smaller than {approx} 10 cm. We also report the discovery of at least two populations of oblique tracks. We evaluated several hypotheses that could explain the observations. No hypothesis was consistent with all the observations, but the preponderance of evidence points toward at least one impact on the central Whipple shield of the spacecraft as the origin of both clustering and low-angle oblique tracks. High-angle oblique tracks unambiguously originate from a non-cometary impact on the spacecraft bus just forward of the collector.

  3. Non-random distribution of amino acids in the transmembrane segments of human type I single span membrane proteins.

    Science.gov (United States)

    Landolt-Marticorena, C; Williams, K A; Deber, C M; Reithmeier, R A

    1993-02-05

    The distribution of amino acids in the transmembrane segments and flanking regions of 115 human type I single span (amino terminus extracellular and carboxyl terminus cytosolic) plasma membrane proteins was found to be non-random. In this sample, Ile was preferentially localized to the amino-terminal region of the hydrophobic transmembrane segments, followed by Val, while Leu predominated in the carboxyl-terminal half of the segment. Although Gly residues were preferentially located in the transmembrane segment, this residue was excluded from the carboxyl-terminal and adjacent boundary regions. Aromatic residues (Tyr, Trp and Phe) occurred preferentially at the cytoplasmic boundary, with Trp also favored at the extracellular boundary. The extracellular flanking sequence amino-terminal to the transmembrane segment was enriched in residues predicted to initiate helix formation (Pro, Asn and Ser), while Arg and Lys were enriched in the cytoplasmic flank where they may function as topological determinants. The positional preferences of these particular amino acids within the transmembrane segment and flanking regions suggests that, in addition to lipid-protein interactions, these residues may participate in specific protein-protein interactions. A consensus sequence motif for type I membrane proteins is proposed and its role in the biosynthesis, folding, assembly and function of these segments is discussed.

  4. Exceptional diversity, non-random distribution, and rapid evolution of retroelements in the B73 maize genome.

    Directory of Open Access Journals (Sweden)

    Regina S Baucom

    2009-11-01

    Full Text Available Recent comprehensive sequence analysis of the maize genome now permits detailed discovery and description of all transposable elements (TEs in this complex nuclear environment. Reiteratively optimized structural and homology criteria were used in the computer-assisted search for retroelements, TEs that transpose by reverse transcription of an RNA intermediate, with the final results verified by manual inspection. Retroelements were found to occupy the majority (>75% of the nuclear genome in maize inbred B73. Unprecedented genetic diversity was discovered in the long terminal repeat (LTR retrotransposon class of retroelements, with >400 families (>350 newly discovered contributing >31,000 intact elements. The two other classes of retroelements, SINEs (four families and LINEs (at least 30 families, were observed to contribute 1,991 and approximately 35,000 copies, respectively, or a combined approximately 1% of the B73 nuclear genome. With regard to fully intact elements, median copy numbers for all retroelement families in maize was 2 because >250 LTR retrotransposon families contained only one or two intact members that could be detected in the B73 draft sequence. The majority, perhaps all, of the investigated retroelement families exhibited non-random dispersal across the maize genome, with LINEs, SINEs, and many low-copy-number LTR retrotransposons exhibiting a bias for accumulation in gene-rich regions. In contrast, most (but not all medium- and high-copy-number LTR retrotransposons were found to preferentially accumulate in gene-poor regions like pericentromeric heterochromatin, while a few high-copy-number families exhibited the opposite bias. Regions of the genome with the highest LTR retrotransposon density contained the lowest LTR retrotransposon diversity. These results indicate that the maize genome provides a great number of different niches for the survival and procreation of a great variety of retroelements that have evolved to

  5. Exceptional diversity, non-random distribution, and rapid evolution of retroelements in the B73 maize genome.

    Science.gov (United States)

    Baucom, Regina S; Estill, James C; Chaparro, Cristian; Upshaw, Naadira; Jogi, Ansuya; Deragon, Jean-Marc; Westerman, Richard P; Sanmiguel, Phillip J; Bennetzen, Jeffrey L

    2009-11-01

    Recent comprehensive sequence analysis of the maize genome now permits detailed discovery and description of all transposable elements (TEs) in this complex nuclear environment. Reiteratively optimized structural and homology criteria were used in the computer-assisted search for retroelements, TEs that transpose by reverse transcription of an RNA intermediate, with the final results verified by manual inspection. Retroelements were found to occupy the majority (>75%) of the nuclear genome in maize inbred B73. Unprecedented genetic diversity was discovered in the long terminal repeat (LTR) retrotransposon class of retroelements, with >400 families (>350 newly discovered) contributing >31,000 intact elements. The two other classes of retroelements, SINEs (four families) and LINEs (at least 30 families), were observed to contribute 1,991 and approximately 35,000 copies, respectively, or a combined approximately 1% of the B73 nuclear genome. With regard to fully intact elements, median copy numbers for all retroelement families in maize was 2 because >250 LTR retrotransposon families contained only one or two intact members that could be detected in the B73 draft sequence. The majority, perhaps all, of the investigated retroelement families exhibited non-random dispersal across the maize genome, with LINEs, SINEs, and many low-copy-number LTR retrotransposons exhibiting a bias for accumulation in gene-rich regions. In contrast, most (but not all) medium- and high-copy-number LTR retrotransposons were found to preferentially accumulate in gene-poor regions like pericentromeric heterochromatin, while a few high-copy-number families exhibited the opposite bias. Regions of the genome with the highest LTR retrotransposon density contained the lowest LTR retrotransposon diversity. These results indicate that the maize genome provides a great number of different niches for the survival and procreation of a great variety of retroelements that have evolved to differentially

  6. Segmental dataset and whole body expression data do not support the hypothesis that non-random movement is an intrinsic property of Drosophila retrogenes

    Directory of Open Access Journals (Sweden)

    Vibranovski Maria D

    2012-09-01

    gonad expression data, we found that autosomal genes analyzed by Metta and Schlötterer are less up regulated in ovaries and have higher chance to be expressed in meiotic cells of spermatogenesis when compared to X-linked genes. Conclusions The criteria used to select retrogenes and the sex-biased expression data based on whole adult flies generated a segmental dataset of female-biased and unbiased expressed genes that was unable to detect the higher propensity of autosomal retrogenes to be expressed in males. Thus, there is no support for the authors’ view that the movement of new retrogenes, which originated from X-linked parental genes, was not driven by selection. Therefore, selection-based genetic models remain the most parsimonious explanations for the observed chromosomal distribution of retrogenes.

  7. Impact of the β-Lactam Resistance Modifier (-)-Epicatechin Gallate on the Non-Random Distribution of Phospholipids across the Cytoplasmic Membrane of Staphylococcus aureus.

    Science.gov (United States)

    Rosado, Helena; Turner, Robert D; Foster, Simon J; Taylor, Peter W

    2015-07-23

    The polyphenol (-)-epicatechin gallate (ECg) inserts into the cytoplasmic membrane (CM) of methicillin-resistant Staphylococcus aureus (MRSA) and reversibly abrogates resistance to β-lactam antibiotics. ECg elicits an increase in MRSA cell size and induces thickened cell walls. As ECg partially delocalizes penicillin-binding protein PBP2 from the septal division site, reduces PBP2 and PBP2a complexation and induces CM remodelling, we examined the impact of ECg membrane intercalation on phospholipid distribution across the CM and determined if ECg affects the equatorial, orthogonal mode of division. The major phospholipids of the staphylococcal CM, lysylphosphatidylglycerol (LPG), phosphatidylglycerol (PG), and cardiolipin (CL), were distributed in highly asymmetric fashion; 95%-97% of LPG was associated with the inner leaflet whereas PG (~90%) and CL (~80%) were found predominantly in the outer leaflet. ECg elicited small, significant changes in LPG distribution. Atomic force microscopy established that ECg-exposed cells divided in similar fashion to control bacteria, with a thickened band of encircling peptidoglycan representing the most recent plane of cell division, less distinct ribs indicative of previous sites of orthogonal division and concentric rings and "knobbles" representing stages of peptidoglycan remodelling during the cell cycle. Preservation of staphylococcal membrane lipid asymmetry and mode of division in sequential orthogonal planes appear key features of ECg-induced stress.

  8. Impact of the β-Lactam Resistance Modifier (−-Epicatechin Gallate on the Non-Random Distribution of Phospholipids across the Cytoplasmic Membrane of Staphylococcus aureus

    Directory of Open Access Journals (Sweden)

    Helena Rosado

    2015-07-01

    Full Text Available The polyphenol (−-epicatechin gallate (ECg inserts into the cytoplasmic membrane (CM of methicillin-resistant Staphylococcus aureus (MRSA and reversibly abrogates resistance to β-lactam antibiotics. ECg elicits an increase in MRSA cell size and induces thickened cell walls. As ECg partially delocalizes penicillin-binding protein PBP2 from the septal division site, reduces PBP2 and PBP2a complexation and induces CM remodelling, we examined the impact of ECg membrane intercalation on phospholipid distribution across the CM and determined if ECg affects the equatorial, orthogonal mode of division. The major phospholipids of the staphylococcal CM, lysylphosphatidylglycerol (LPG, phosphatidylglycerol (PG, and cardiolipin (CL, were distributed in highly asymmetric fashion; 95%–97% of LPG was associated with the inner leaflet whereas PG (~90% and CL (~80% were found predominantly in the outer leaflet. ECg elicited small, significant changes in LPG distribution. Atomic force microscopy established that ECg-exposed cells divided in similar fashion to control bacteria, with a thickened band of encircling peptidoglycan representing the most recent plane of cell division, less distinct ribs indicative of previous sites of orthogonal division and concentric rings and “knobbles” representing stages of peptidoglycan remodelling during the cell cycle. Preservation of staphylococcal membrane lipid asymmetry and mode of division in sequential orthogonal planes appear key features of ECg-induced stress.

  9. Non-Random Distribution of 5S rDNA Sites and Its Association with 45S rDNA in Plant Chromosomes.

    Science.gov (United States)

    Roa, Fernando; Guerra, Marcelo

    2015-01-01

    5S and 45S rDNA sites are the best mapped chromosome regions in eukaryotic chromosomes. In this work, a database was built gathering information about the position and number of 5S rDNA sites in 784 plant species, aiming to identify patterns of distribution along the chromosomes and its correlation with the position of 45S rDNA sites. Data revealed that in most karyotypes (54.5%, including polyploids) two 5S rDNA sites (a single pair) are present, with 58.7% of all sites occurring in the short arm, mainly in the proximal region. In karyotypes of angiosperms with only 1 pair of sites (single sites) they are mostly found in the proximal region (52.0%), whereas in karyotypes with multiple sites the location varies according to the average chromosome size. Karyotypes with multiple sites and small chromosomes (6 µm) more commonly show terminal or interstitial sites. In species with holokinetic chromosomes, the modal value of sites per karyotype was also 2, but they were found mainly in a terminal position. Adjacent 5S and 45S rDNA sites were often found in the short arm, reflecting the preferential distribution of both sites in this arm. The high frequency of genera with at least 1 species with adjacent 5S and 45S sites reveals that this association appeared several times during angiosperm evolution, but it has been maintained only rarely as the dominant array in plant genera. © 2015 S. Karger AG, Basel.

  10. Supporting Flexible Data Distribution in Software DSMs

    Institute of Scientific and Technical Information of China (English)

    洪锦伟; 陈国良; 张兆庆

    2000-01-01

    Page-based software DSM systems suffer from false sharing caused by the large sharing granularity, and only support one-dimension Block or Cyclic block data distribution schemes. Thus applications running on them will suffer from poor data locality and will be able to exploit parallelism only when using a large number of processors. In this paper, a way towards supporting flexible data distribu tion (FDD) on software DSM system is presented. Small granularity-tunable blocks, the size of which can be set by compiler or programmer, are used to overlap the working data sets distributed among processors. The FDD was implemented on a software DSM system called JIAJiA. Compared with Block/Cyclic-block distribution schemes used by most DSM systems now, experiments show that the proposed way of flexible data distribution is more effective. The performance of the applications used in the experiments is significantly improved.

  11. Evidence for Non-Random Hydrophobicity Structures in Protein Chains

    CERN Document Server

    Irbäck, A; Potthast, F; Irb\\"ack, Anders; Peterson, Carsten; Potthast, Frank

    1996-01-01

    The question of whether proteins originate from random sequences of amino acids is addressed. A statistical analysis is performed in terms of blocked and random walk values formed by binary hydrophobic assignments of the amino acids along the protein chains. Theoretical expectations of these variables from random distributions of hydrophobicities are compared with those obtained from functional proteins. The results, which are based upon proteins in the SWISS-PROT data base, convincingly show that the amino acid sequences in proteins differ from what is expected from random sequences in a statistical significant way. By performing Fourier transforms on the random walks one obtains additional evidence for non-randomness of the distributions. We have also analyzed results from a synthetic model containing only two amino-acid types, hydrophobic and hydrophilic. With reasonable criteria on good folding properties in terms of thermodynamical and kinetic behavior, sequences that fold well are isolated. Performing t...

  12. Learning from Distributions via Support Measure Machines

    CERN Document Server

    Muandet, Krikamol; Fukumizu, Kenji; Dinuzzo, Francesco

    2012-01-01

    This paper presents a kernel-based discriminative learning framework on probability measures. Rather than relying on large collections of vectorial training examples, our framework learns using a collection of probability distributions that have been constructed to meaningfully represent training data. By representing these probability distributions as mean embeddings in the reproducing kernel Hilbert space (RKHS), we are able to apply many standard kernel-based learning techniques in straightforward fashion. To accomplish this, we construct a generalization of the support vector machine (SVM) called a support measure machine (SMM). Our analyses of SMMs provides several insights into their relationship to traditional SVMs. Based on such insights, we propose a flexible SVM (Flex-SVM) that places different kernel functions on each training example. Experimental results on both synthetic and real-world data demonstrate the effectiveness of our proposed framework.

  13. Support For Distributed Programming In Extreme Style

    Directory of Open Access Journals (Sweden)

    Jacek Dajda

    2005-01-01

    Full Text Available The basic limitation emerging from practising eXtreme Programming methodology is theconstraint of close physical proximity between the members of the collaborating team including customer. This became the main idea behind research on XP supporting environmentfor geographically distributed teams. This work presents basic assumptions, elaborated architecture and selected implementation issues for the system of this type. Deliberations aresupplied with the initial results of the verification of its usability based on the users tests.

  14. DISTRIBUTED COMPUTING SUPPORT SERVICE USER SURVEY

    CERN Multimedia

    2001-01-01

    IT Division operates a Distributed Computing Support Service, which offers support to owners and users of all variety of desktops throughout CERN as well as more dedicated services for certain groups, divisions and experiments. It also provides the staff who operate the central and satellite Computing Helpdesks, it supports printers throughout the site and it provides the installation activities of the IT Division PC Service. We have published a questionnaire, which seeks to gather your feedback on how the services are seen, how they are progressing and how they can be improved. Please take a few minutes to fill in this questionnaire. Replies will be treated in confidence if desired although you may also request an opportunity to be contacted by CERN's service management directly. Please tell us if you met problems but also if you had a successful conclusion to your request for assistance. You will find the questionnaire at the web site http://wwwinfo/support/survey/desktop-contract There will also be a link...

  15. DISTRIBUTED COMPUTING SUPPORT CONTRACT USER SURVEY

    CERN Multimedia

    2001-01-01

    IT Division operates a Distributed Computing Support Service, which offers support to owners and users of all variety of desktops throughout CERN as well as more dedicated services for certain groups, divisions and experiments. It also provides the staff who operate the central and satellite Computing Helpdesks, it supports printers throughout the site and it provides the installation activities of the IT Division PC Service. We have published a questionnaire which seeks to gather your feedback on how the services are seen, how they are progressing and how they can be improved. Please take a few minutes to fill in this questionnaire. Replies will be treated in confidence if desired although you may also request an opportunity to be contacted by CERN's service management directly. Please tell us if you met problems but also if you had a successful conclusion to your request for assistance. You will find the questionnaire at the web site http://wwwinfo/support/survey/desktop-contract There will also be a link ...

  16. Belonging to a peer support group enhance the quality of life and adherence rate in patients affected by breast cancer: A non-randomized controlled clinical trialFNx01

    Directory of Open Access Journals (Sweden)

    Afsaneh Malekpour Tehrani

    2011-01-01

    Full Text Available Background: Breast cancer is the most common cancer in women. It seems that breast cancer patients benefit from meeting someone who had a similar experience. This study evaluated the effect of two kinds of interventions (peer support and educational program on quality of life in breast cancer patients. Methods: This study was a controlled clinical trial on women with non-metastatic breast cancer. The patients studied in two experimental and control groups. Experimental group took part in peer support program and control group passed a routine educational program during 3 months. The authors administered SF-36 for evaluating the quality of life pre-and post intervention. Also, patient′s adherence was assessed by means of a simple checklist. Results: Two groups were similar with respect of age, age of onset of the disease, duration of having breast cancer, marital status, type of the treatment receiving now, and type of the received surgery. In the control group, there were statistically significant improvements in body pain, role-physical, role-emotional and social functioning. In experimental group, role-physical, vitality, social functioning, role-emotional and mental health showed significant improvement. Vitality score and mental health score in experimental group was significantly higher than that of the control group, both with p < 0.001. Also, it was shown that adherence was in high levels in both groups and no significant difference was seen after the study was done. Conclusions: According to the results of this study, supporting the patients with breast cancer by forming peer groups or by means of educational sessions could improve their life qualities.

  17. Patterns of turnover and floristic similarity show a non-random distribution of naturalized flora in Chile, South America Patrones de recambio y similitud florística muestran una distribución no aleatoria de la flora naturalizada en Chile, Sudamérica

    Directory of Open Access Journals (Sweden)

    SERGIO A CASTRO

    2008-03-01

    Full Text Available The current geographical distribution of alien species could be informative of processes involved in the biological invasions facilitated by humans. Because environmental and anthropic factors affect the geographic distribution of alien plants, we hypothesize that naturalized plants have a non-random distribution along extensive geographical ranges. On the basis of a complete and updated database of naturalized plants in Chile, we analyzed their turnover and floristic similarities among regions that encompass a wide latitudinal gradient in South America. Using Moran's index and Mantel's test we characterized the spatial auto-correlation (regional aggregation and the effect of geographical distance on the index values. Additionally, we used clustering methods and resampling procedures to detect plant assemblages at regional level. Whittaker's index displayed a positive tilt, increasing according to geographical distance and reaching a plateau; conversely, Jaccard's index was negatively associated with geographical distance. Removing the effect of distance, both Whittaker's and Jaccard's values showed no significant trends. Multivariate analysis combined with resampling procedures revealed the existence of three distinctive plant clusters: Northernmost Chile, Central-southern Chile, and Southernmost Chile. These clusters are characterized by naturalized plants that are not present in the others. Based on this evidence, we conclude that the set of naturalized plants in Chile exhibits a non-random geographical distribution, displaying an ordered geographical pattern across regions (latitude. We discuss the role of the environmental variables (climate, latitude and land use post-European colonization as factors in the distributional patterns here documentedLa distribución geográfica actual de especies exóticas puede ser informativa de los procesos involucrados en las invasiones biológicas facilitadas por humanos. Debido a que los factores

  18. REFINABLE DISTRIBUTIONS SUPPORTED ON SELF-AFFINE TILES

    Institute of Scientific and Technical Information of China (English)

    DaiXinrong

    2002-01-01

    In this paper,some conditions which assure the compactly supported refinable distributions supported on a self-affine tile to be Lebesgue-Stieltjes measures or absolutely continuous measures with respect to Lebesgue-Stieltjes measures are given.

  19. Content Management Middleware for the Support of Distributed Teaching

    Science.gov (United States)

    Tsalapatas, Hariklia; Stav, John B.; Kalantzis, Christos

    2004-01-01

    eCMS is a web-based federated content management system for the support of distributed teaching based on an open, distributed middleware architecture for the publication, discovery, retrieval, and integration of educational material. The infrastructure supports the management of both standalone material and structured courses, as well as the…

  20. Control Scheme for Distributed Generator Providing Network Voltage Support

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    The distributed generator over the last 30 years has posed several challenges when they are connected to a distributed network. The most immediate problem is to change the voltage at the connection point depending on the power supplied to the network and may cause it to exceed statutory limits. This paper describes a new control scheme for a distributed generator for supporting the voltage control in the network, thus ensuring the distributed generator to contribute to network voltage management. The scheme performance is demonstrated by a model for a distributed generator connected to a distribution network. The result shows that using the new control scheme, the distribution network voltage constraints are maintained while maximizing the active power delivered by distributed generators.

  1. Controlling the Distribution of Supported Nanoparticles by Aqueous Synthesis

    NARCIS (Netherlands)

    Eggenhuisen, T.M.; Friedrich, H.; Nudelman, F.; Zečević, J.; Sommerdijk, N.A.J.M.; de Jongh, P.E.; de Jong, K.P.

    2013-01-01

    Synthesis of supported nanoparticles with controlled size and uniform distribution is a major challenge in nanoscience, in particular for applications in catalysis. Cryo-electron tomography revealed with nanometer resolution the 3D distribution of phases present during nanoparticle synthesis via imp

  2. Distributed Computing with Centralized Support Works at Brigham Young.

    Science.gov (United States)

    McDonald, Kelly; Stone, Brad

    1992-01-01

    Brigham Young University (Utah) has addressed the need for maintenance and support of distributed computing systems on campus by implementing a program patterned after a national business franchise, providing the support and training of a centralized administration but allowing each unit to operate much as an independent small business.…

  3. Voltage Support from Electric Vehicles in Distribution Grid

    DEFF Research Database (Denmark)

    Huang, Shaojun; Pillai, Jayakrishnan Radhakrishna; Bak-Jensen, Birgitte

    2013-01-01

    , the combination of these two methods is also examined for controlled EV charging. Simulation results show that the combination of the two individual supporting methods has the best performance in terms of voltage regulation as well as improving EV penetration level at weak distribution grids.......The paper evaluates the voltage support functions from electric vehicles (EVs) on a typical Danish distribution grid with high EV penetration. In addition to the popular voltage control modes, such as voltage droop charging (low voltage level leads to low charging power) and reactive power support...

  4. Distributed Generation to Support Development-Focused Climate Action

    Energy Technology Data Exchange (ETDEWEB)

    Cox, Sadie; Gagnon, Pieter; Stout, Sherry; Zinaman, Owen; Watson, Andrea; Hotchkiss, Eliza

    2016-09-01

    This paper explores the role of distributed generation, with a high renewable energy contribution, in supporting low emission climate-resilient development. The paper presents potential impacts on development (via energy access), greenhouse gas emission mitigation, and climate resilience directly associated with distributed generation, as well as specific actions that may enhance or increase the likelihood of climate and development benefits. This paper also seeks to provide practical and timely insights to support distributed generation policymaking and planning within the context of common climate and development goals as the distributed generation landscape rapidly evolves globally. Country-specific distributed generation policy and program examples, as well as analytical tools that can inform efforts internationally, are also highlighted throughout the paper.

  5. Generalized Cumulative Residual Entropy for Distributions with Unrestricted Supports

    Directory of Open Access Journals (Sweden)

    Noomane Drissi

    2008-01-01

    Full Text Available We consider the cumulative residual entropy (CRE a recently introduced measure of entropy. While in previous works distributions with positive support are considered, we generalize the definition of CRE to the case of distributions with general support. We show that several interesting properties of the earlier CRE remain valid and supply further properties and insight to problems such as maximum CRE power moment problems. In addition, we show that this generalized CRE can be used as an alternative to differential entropy to derive information-based optimization criteria for system identification purpose.

  6. A distributed computing approach to mission operations support. [for spacecraft

    Science.gov (United States)

    Larsen, R. L.

    1975-01-01

    Computing mission operation support includes orbit determination, attitude processing, maneuver computation, resource scheduling, etc. The large-scale third-generation distributed computer network discussed is capable of fulfilling these dynamic requirements. It is shown that distribution of resources and control leads to increased reliability, and exhibits potential for incremental growth. Through functional specialization, a distributed system may be tuned to very specific operational requirements. Fundamental to the approach is the notion of process-to-process communication, which is effected through a high-bandwidth communications network. Both resource-sharing and load-sharing may be realized in the system.

  7. Questioning in Distributed Product Development Teams: Supporting Shared Understanding

    DEFF Research Database (Denmark)

    Cash, Philip; Ahmed-Kristensen, Saeema

    2015-01-01

    Distributed teams are an increasingly common feature of New Product Development (NPD). Key to the success of these teams is the development of both short and longerterm shared understanding. Lack of shared understanding has been recognized as a significant challenge, particularly in the context...... globally distributed NPD activities. Poor shared understanding can ultimately result in delays and rework. One major antecedent of shared understanding development is question asking. This work uses a quasiexperimental study to test the impact of questioning support on different types of distributed teams...

  8. A support architecture for reliable distributed computing systems

    Science.gov (United States)

    Dasgupta, Partha; Leblanc, Richard J., Jr.

    1988-01-01

    The Clouds project is well underway to its goal of building a unified distributed operating system supporting the object model. The operating system design uses the object concept of structuring software at all levels of the system. The basic operating system was developed and work is under progress to build a usable system.

  9. 45 CFR 302.51 - Distribution of support collections.

    Science.gov (United States)

    2010-10-01

    ... HUMAN SERVICES STATE PLAN REQUIREMENTS § 302.51 Distribution of support collections. The State plan... the IV-D program as a condition of Food Stamp eligibility as defined at § 273.11(o) and (p) of title 7...-D program as a condition of Food Stamp eligibility as defined at § 273.11(o) and (p) of title 7....

  10. Interactive Room Support for Complex and Distributed Design Projects

    DEFF Research Database (Denmark)

    Grønbæk, Kaj; Gundersen, Kristian Kroyer; Mogensen, Preben Holst

    2001-01-01

    notion of interactive room technology supporting industrial design and describes two examples of this technology: the Designers' Workbench and the 3D Whiteboard, both integrated in a common distributed and collaborative infrastructure. The paper also describes a number of new easy-to-grab and lightweight...

  11. Inbreeding avoidance through non-random mating in sticklebacks.

    Science.gov (United States)

    Frommen, Joachim G; Bakker, Theo C M

    2006-06-22

    Negative effects of inbreeding are well documented in a wide range of animal taxa. Hatching success and survival of inbred offspring is reduced in many species and inbred progeny are often less attractive to potential mates. Thus, individuals should avoid mating with close kin. However, experimental evidence for inbreeding avoidance through non-random mating in vertebrates is scarce. Here, we show that gravid female three-spined sticklebacks (Gasterosteus aculeatus) when given the choice between a courting familiar brother and a courting unfamiliar non-sib prefer to mate with the non-sib and thus avoid the disadvantages of incest. We controlled for differences in males' body size and red intensity of nuptial coloration. Thus, females adjust their courting behaviour to the risk of inbreeding.

  12. Statistical analyses support power law distributions found in neuronal avalanches.

    Directory of Open Access Journals (Sweden)

    Andreas Klaus

    Full Text Available The size distribution of neuronal avalanches in cortical networks has been reported to follow a power law distribution with exponent close to -1.5, which is a reflection of long-range spatial correlations in spontaneous neuronal activity. However, identifying power law scaling in empirical data can be difficult and sometimes controversial. In the present study, we tested the power law hypothesis for neuronal avalanches by using more stringent statistical analyses. In particular, we performed the following steps: (i analysis of finite-size scaling to identify scale-free dynamics in neuronal avalanches, (ii model parameter estimation to determine the specific exponent of the power law, and (iii comparison of the power law to alternative model distributions. Consistent with critical state dynamics, avalanche size distributions exhibited robust scaling behavior in which the maximum avalanche size was limited only by the spatial extent of sampling ("finite size" effect. This scale-free dynamics suggests the power law as a model for the distribution of avalanche sizes. Using both the Kolmogorov-Smirnov statistic and a maximum likelihood approach, we found the slope to be close to -1.5, which is in line with previous reports. Finally, the power law model for neuronal avalanches was compared to the exponential and to various heavy-tail distributions based on the Kolmogorov-Smirnov distance and by using a log-likelihood ratio test. Both the power law distribution without and with exponential cut-off provided significantly better fits to the cluster size distributions in neuronal avalanches than the exponential, the lognormal and the gamma distribution. In summary, our findings strongly support the power law scaling in neuronal avalanches, providing further evidence for critical state dynamics in superficial layers of cortex.

  13. Statistical analyses support power law distributions found in neuronal avalanches.

    Science.gov (United States)

    Klaus, Andreas; Yu, Shan; Plenz, Dietmar

    2011-01-01

    The size distribution of neuronal avalanches in cortical networks has been reported to follow a power law distribution with exponent close to -1.5, which is a reflection of long-range spatial correlations in spontaneous neuronal activity. However, identifying power law scaling in empirical data can be difficult and sometimes controversial. In the present study, we tested the power law hypothesis for neuronal avalanches by using more stringent statistical analyses. In particular, we performed the following steps: (i) analysis of finite-size scaling to identify scale-free dynamics in neuronal avalanches, (ii) model parameter estimation to determine the specific exponent of the power law, and (iii) comparison of the power law to alternative model distributions. Consistent with critical state dynamics, avalanche size distributions exhibited robust scaling behavior in which the maximum avalanche size was limited only by the spatial extent of sampling ("finite size" effect). This scale-free dynamics suggests the power law as a model for the distribution of avalanche sizes. Using both the Kolmogorov-Smirnov statistic and a maximum likelihood approach, we found the slope to be close to -1.5, which is in line with previous reports. Finally, the power law model for neuronal avalanches was compared to the exponential and to various heavy-tail distributions based on the Kolmogorov-Smirnov distance and by using a log-likelihood ratio test. Both the power law distribution without and with exponential cut-off provided significantly better fits to the cluster size distributions in neuronal avalanches than the exponential, the lognormal and the gamma distribution. In summary, our findings strongly support the power law scaling in neuronal avalanches, providing further evidence for critical state dynamics in superficial layers of cortex.

  14. Modelling and validation of particle size distributions of supported nanoparticles using the pair distribution function technique

    Energy Technology Data Exchange (ETDEWEB)

    Gamez-Mendoza, Liliana; Terban, Maxwell W.; Billinge, Simon J. L.; Martinez-Inesta, Maria

    2017-04-13

    The particle size of supported catalysts is a key characteristic for determining structure–property relationships. It is a challenge to obtain this information accurately andin situusing crystallographic methods owing to the small size of such particles (<5 nm) and the fact that they are supported. In this work, the pair distribution function (PDF) technique was used to obtain the particle size distribution of supported Pt catalysts as they grow under typical synthesis conditions. The PDF of Pt nanoparticles grown on zeolite X was isolated and refined using two models: a monodisperse spherical model (single particle size) and a lognormal size distribution. The results were compared and validated using scanning transmission electron microscopy (STEM) results. Both models describe the same trends in average particle size with temperature, but the results of the number-weighted lognormal size distributions can also accurately describe the mean size and the width of the size distributions obtained from STEM. Since the PDF yields crystallite sizes, these results suggest that the grown Pt nanoparticles are monocrystalline. This work shows that refinement of the PDF of small supported monocrystalline nanoparticles can yield accurate mean particle sizes and distributions.

  15. Coordinating complex decision support activities across distributed applications

    Science.gov (United States)

    Adler, Richard M.

    1994-01-01

    Knowledge-based technologies have been applied successfully to automate planning and scheduling in many problem domains. Automation of decision support can be increased further by integrating task-specific applications with supporting database systems, and by coordinating interactions between such tools to facilitate collaborative activities. Unfortunately, the technical obstacles that must be overcome to achieve this vision of transparent, cooperative problem-solving are daunting. Intelligent decision support tools are typically developed for standalone use, rely on incompatible, task-specific representational models and application programming interfaces (API's), and run on heterogeneous computing platforms. Getting such applications to interact freely calls for platform independent capabilities for distributed communication, as well as tools for mapping information across disparate representations. Symbiotics is developing a layered set of software tools (called NetWorks! for integrating and coordinating heterogeneous distributed applications. he top layer of tools consists of an extensible set of generic, programmable coordination services. Developers access these services via high-level API's to implement the desired interactions between distributed applications.

  16. LaRC local area networks to support distributed computing

    Science.gov (United States)

    Riddle, E. P.

    1984-01-01

    The Langley Research Center's (LaRC) Local Area Network (LAN) effort is discussed. LaRC initiated the development of a LAN to support a growing distributed computing environment at the Center. The purpose of the network is to provide an improved capability (over inteactive and RJE terminal access) for sharing multivendor computer resources. Specifically, the network will provide a data highway for the transfer of files between mainframe computers, minicomputers, work stations, and personal computers. An important influence on the overall network design was the vital need of LaRC researchers to efficiently utilize the large CDC mainframe computers in the central scientific computing facility. Although there was a steady migration from a centralized to a distributed computing environment at LaRC in recent years, the work load on the central resources increased. Major emphasis in the network design was on communication with the central resources within the distributed environment. The network to be implemented will allow researchers to utilize the central resources, distributed minicomputers, work stations, and personal computers to obtain the proper level of computing power to efficiently perform their jobs.

  17. Supporting shared data structures on distributed memory architectures

    Science.gov (United States)

    Koelbel, Charles; Mehrotra, Piyush; Vanrosendale, John

    1990-01-01

    Programming nonshared memory systems is more difficult than programming shared memory systems, since there is no support for shared data structures. Current programming languages for distributed memory architectures force the user to decompose all data structures into separate pieces, with each piece owned by one of the processors in the machine, and with all communication explicitly specified by low-level message-passing primitives. A new programming environment is presented for distributed memory architectures, providing a global name space and allowing direct access to remote parts of data values. The analysis and program transformations required to implement this environment are described, and the efficiency of the resulting code on the NCUBE/7 and IPSC/2 hypercubes are described.

  18. Shared Visualizations in Support of Distributed Creative Communities

    Directory of Open Access Journals (Sweden)

    Alastair Weakley

    2004-05-01

    Full Text Available The paper is concerned with support for distributed groups of creative knowledge workers: in this case designers. We consider requirements that designers have regarding internalisation and externalisation of ideas and concepts as well as requirements relating to collaboration. We review an online system whose facilities for the graphical representation of data were found to be popular. The evaluation was in the context of a group task and the results, including instances of tacit knowledge sharing, have led us to formulate a number of recommendations as to how such systems might be made still more effective for collaborative working.

  19. Globus Toolkit Support for Distributed Data—Intensive Science

    Institute of Scientific and Technical Information of China (English)

    W.Alcock; A.Chervenak; 等

    2001-01-01

    In high-energy physics,terabyte and soon petabyte-scale data collections are emerging as critical community resources.A new class of "Data Grid" infrastructure is required to support distributed access to and analysis of these datasets by potentially thousands of users.Data Grid technology is being deployed in numerous experiments through collaborationssuch as the EU DataGrid,the Grid Physics Network,and the Particel Physics Data Grid[1],The Globus Toolkit is a widely used set of services designed to support the creation of these Grid infrastrunctures and applications,In this paper we survey the Globus technologies that will play a major role in the development and deployment for these Grids.

  20. MicROS-drt: supporting real-time and scalable data distribution in distributed robotic systems.

    Science.gov (United States)

    Ding, Bo; Wang, Huaimin; Fan, Zedong; Zhang, Pengfei; Liu, Hui

    A primary requirement in distributed robotic software systems is the dissemination of data to all interested collaborative entities in a timely and scalable manner. However, providing such a service in a highly dynamic and resource-limited robotic environment is a challenging task, and existing robot software infrastructure has limitations in this aspect. This paper presents a novel robot software infrastructure, micROS-drt, which supports real-time and scalable data distribution. The solution is based on a loosely coupled data publish-subscribe model with the ability to support various time-related constraints. And to realize this model, a mature data distribution standard, the data distribution service for real-time systems (DDS), is adopted as the foundation of the transport layer of this software infrastructure. By elaborately adapting and encapsulating the capability of the underlying DDS middleware, micROS-drt can meet the requirement of real-time and scalable data distribution in distributed robotic systems. Evaluation results in terms of scalability, latency jitter and transport priority as well as the experiment on real robots validate the effectiveness of this work.

  1. CLIPS based decision support system for Water Distribution Networks

    Directory of Open Access Journals (Sweden)

    S. Kulshrestha

    2011-03-01

    Full Text Available The Water Distribution Networks (WDN are managed by experts, who, over the years of their association and responsibility, acquire an empirical knowledge of the system and, characteristically, this knowledge remains largely confined to their respective personal domains. In the event of any new information and/or emergence of a new problem, these experts apply simple heuristics to design corrective measures and cognitively seek to predict network performance. The human interference leads to inefficient utilization of resources and unfair distribution. Researchers over the past, have tried to address to the problem and they have applied Artificial Intelligence (AI tool to automate the decision process and encode the heuristic rules. The application of AI tool in the field of WDN management is meager. This paper describes a component of an ongoing research initiative to investigate the potential application of artificial intelligence package CLIPS (short for C Language Integrated Production System, developed at NASA/Johnson Space Center in the development of an expert decision support system for management of a water distribution network. The system aims to meet several concerns of modern water utility managers as it attempts to formalize operational and management experiences, and provides a frame work for assisting water utility managers even in the absence of expert personnel.

  2. Supporting Collective Inquiry: A Technology Framework for Distributed Learning

    Science.gov (United States)

    Tissenbaum, Michael

    This design-based study describes the implementation and evaluation of a technology framework to support smart classrooms and Distributed Technology Enhanced Learning (DTEL) called SAIL Smart Space (S3). S3 is an open-source technology framework designed to support students engaged in inquiry investigations as a knowledge community. To evaluate the effectiveness of S3 as a generalizable technology framework, a curriculum named PLACE (Physics Learning Across Contexts and Environments) was developed to support two grade-11 physics classes (n = 22; n = 23) engaged in a multi-context inquiry curriculum based on the Knowledge Community and Inquiry (KCI) pedagogical model. This dissertation outlines three initial design studies that established a set of design principles for DTEL curricula, and related technology infrastructures. These principles guided the development of PLACE, a twelve-week inquiry curriculum in which students drew upon their community-generated knowledge base as a source of evidence for solving ill-structured physics problems based on the physics of Hollywood movies. During the culminating smart classroom activity, the S3 framework played a central role in orchestrating student activities, including managing the flow of materials and students using real-time data mining and intelligent agents that responded to emergent class patterns. S3 supported students' construction of knowledge through the use individual, collective and collaborative scripts and technologies, including tablets and interactive large-format displays. Aggregate and real-time ambient visualizations helped the teacher act as a wondering facilitator, supporting students in their inquiry where needed. A teacher orchestration tablet gave the teacher some control over the flow of the scripted activities, and alerted him to critical moments for intervention. Analysis focuses on S3's effectiveness in supporting students' inquiry across multiple learning contexts and scales of time, and in

  3. DISTRIBUTED LEADERSHIP COLLABORATION FACTORS TO SUPPORT IDEA GENERATION IN COMPUTER-SUPPORTED COLLABORATIVE e-LEARNING

    Directory of Open Access Journals (Sweden)

    Niki Lambropoulos

    2011-01-01

    Full Text Available This paper aims to identify, discuss and analyze students’ collaboration factors related to distributed leadership (DL, which correlates with interaction quality evident in idea generation. Scripting computer-supported collaborative e-learning (CSCeL activities based on DL can scaffold students’ interactions that support collaboration and promote idea generation. Furthermore, the associated tools can facilitate collaboration via scripting and shed light on students’ interactions and dialogical sequences. Such detailed planning can result in effective short e-courses. In this case study, 21 MSc students’ teams worked on a DL project within a 2-day e-course at the IT Institute (ITIN, France. The research methods involved a self-reported questionnaire; the Non-Negative Matrix Factorization (NNMF algorithm with qualitative analysis; and outcomes from the Social Network Analysis (SNA tools implemented within the forums. The results indicated that scripting DL based on the identified distributed leadership attributes can support values such as collaboration and can be useful in supporting idea generation in short e-courses.

  4. Reducing bias in survival under non-random temporary emigration

    Science.gov (United States)

    Peñaloza, Claudia L.; Kendall, William L.; Langtimm, Catherine Ann

    2014-01-01

    Despite intensive monitoring, temporary emigration from the sampling area can induce bias severe enough for managers to discard life-history parameter estimates toward the terminus of the times series (terminal bias). Under random temporary emigration unbiased parameters can be estimated with CJS models. However, unmodeled Markovian temporary emigration causes bias in parameter estimates and an unobservable state is required to model this type of emigration. The robust design is most flexible when modeling temporary emigration, and partial solutions to mitigate bias have been identified, nonetheless there are conditions were terminal bias prevails. Long-lived species with high adult survival and highly variable non-random temporary emigration present terminal bias in survival estimates, despite being modeled with the robust design and suggested constraints. Because this bias is due to uncertainty about the fate of individuals that are undetected toward the end of the time series, solutions should involve using additional information on survival status or location of these individuals at that time. Using simulation, we evaluated the performance of models that jointly analyze robust design data and an additional source of ancillary data (predictive covariate on temporary emigration, telemetry, dead recovery, or auxiliary resightings) in reducing terminal bias in survival estimates. The auxiliary resighting and predictive covariate models reduced terminal bias the most. Additional telemetry data was effective at reducing terminal bias only when individuals were tracked for a minimum of two years. High adult survival of long-lived species made the joint model with recovery data ineffective at reducing terminal bias because of small-sample bias. The naïve constraint model (last and penultimate temporary emigration parameters made equal), was the least efficient, though still able to reduce terminal bias when compared to an unconstrained model. Joint analysis of several

  5. Distributed Hydrologic Modeling Apps for Decision Support in the Cloud

    Science.gov (United States)

    Swain, N. R.; Latu, K.; Christiensen, S.; Jones, N.; Nelson, J.

    2013-12-01

    Advances in computation resources and greater availability of water resources data represent an untapped resource for addressing hydrologic uncertainties in water resources decision-making. The current practice of water authorities relies on empirical, lumped hydrologic models to estimate watershed response. These models are not capable of taking advantage of many of the spatial datasets that are now available. Physically-based, distributed hydrologic models are capable of using these data resources and providing better predictions through stochastic analysis. However, there exists a digital divide that discourages many science-minded decision makers from using distributed models. This divide can be spanned using a combination of existing web technologies. The purpose of this presentation is to present a cloud-based environment that will offer hydrologic modeling tools or 'apps' for decision support and the web technologies that have been selected to aid in its implementation. Compared to the more commonly used lumped-parameter models, distributed models, while being more intuitive, are still data intensive, computationally expensive, and difficult to modify for scenario exploration. However, web technologies such as web GIS, web services, and cloud computing have made the data more accessible, provided an inexpensive means of high-performance computing, and created an environment for developing user-friendly apps for distributed modeling. Since many water authorities are primarily interested in the scenario exploration exercises with hydrologic models, we are creating a toolkit that facilitates the development of a series of apps for manipulating existing distributed models. There are a number of hurdles that cloud-based hydrologic modeling developers face. One of these is how to work with the geospatial data inherent with this class of models in a web environment. Supporting geospatial data in a website is beyond the capabilities of standard web frameworks and it

  6. Distributed Medium Access Control with SDMA Support for WLANs

    Science.gov (United States)

    Zhou, Sheng; Niu, Zhisheng

    With simultaneous multi-user transmissions, spatial division multiple access (SDMA) provides substantial throughput gain over the single user transmission. However, its implementation in WLANs with contention-based IEEE 802.11 MAC remains challenging. Problems such as coordinating and synchronizing the multiple users need to be solved in a distributed way. In this paper, we propose a distributed MAC protocol for WLANs with SDMA support. A dual-mode CTS responding mechanism is designed to accomplish the channel estimation and user synchronization required for SDMA. We analytically study the throughput performance of the proposed MAC, and dynamic parameter adjustment is designed to enhance the protocol efficiency. In addition, the proposed MAC protocol does not rely on specific physical layer realizations, and can work on legacy IEEE 802.11 equipment with slight software updates. Simulation results show that the proposed MAC outperforms IEEE 802.11 significantly, and that the dynamic parameter adjustment can effectively track the load variation in the network.

  7. 42 CFR 421.505 - Termination and extension of non-random prepayment complex medical review.

    Science.gov (United States)

    2010-10-01

    ... a provider or supplier must be on non-random prepayment complex medical review. There is no minimum... section, a contractor must terminate a provider or supplier from non-random prepayment complex medical... complex medical review if a provider or supplier stops billing the code under review, shifts billing...

  8. Medicare Program; termination of non-random prepayment complex medical review. Final rule.

    Science.gov (United States)

    2008-09-26

    This final rule implements requirements regarding the termination of non-random prepayment complex medical review as required under the Medicare Prescription Drug, Improvement and Modernization Act of 2003. This final rule sets forth the criteria CMS contractors will use for terminating a provider or supplier from non-random prepayment complex medical review.

  9. A prospective, non-randomized study of home use of mifepristone for medical abortion in the U.S.

    Science.gov (United States)

    Chong, Erica; Frye, Laura J; Castle, Jen; Dean, Gillian; Kuehl, Laurel; Winikoff, Beverly

    2015-09-01

    To determine the acceptability of taking mifepristone at home for early medical abortion in the United States. This prospective, non-randomized, open-label study at six Planned Parenthood centers gave women with pregnancies up to 63 days' gestation seeking medical abortion the choice of taking mifepristone in the center or at home. Participants were interviewed at a follow-up visit 1-2 weeks after mifepristone administration to assess their experience with the option they selected. Four-hundred women were enrolled between April 2013 and June 2014 of which 32% (n=128) chose to take mifepristone at home. Abortion success rates did not differ between home and center users (96% and 97%). Among home users, 82% reported taking the mifepristone at the time they planned with their provider and no participant took it after 63 days' gestation. The most common reason cited for selecting home use was scheduling flexibility and significantly more home users took misoprostol on the weekend (50% vs. 36%, p=.02). Home users were more likely than center users to report missing no days of work due to the abortion (47% vs. 28%, p=.08). Ninety-nine percent of home users reported that they would take mifepristone at home again and 96% would recommend home use to a friend. Offering this option did not increase the service delivery burden on study providers, who would recommend home use in the future for most participants. Home use of mifepristone is a highly acceptable practice for which there is current demand, and it should be offered as part of routine medical abortion services. Offering the option of home use of mifepristone to medical abortion patients can provide women and clinics with more flexibility while maintaining a safe, effective and acceptable service. These results provide support for telemedicine or pharmacy distribution. Copyright © 2015 Elsevier Inc. All rights reserved.

  10. Microstructural descriptors and cellular automata simulation of the effects of non-random nuclei location on recrystallization in two dimensions

    Directory of Open Access Journals (Sweden)

    Paulo Rangel Rios

    2006-06-01

    Full Text Available The effect of non-random nuclei location and the efficiency of microstructural descriptors in assessing such a situation are studied. Cellular automata simulation of recrystallization in two dimensions is carried out to simulate microstrutural evolution for nuclei distribution ranging from a periodic arrangement to clusters of nuclei. The simulation results are compared in detail with microstrutural descriptors normally used to follow transformation evolution. It is shown that the contiguity is particularly relevant to detect microstructural deviations from randomness. This work focuses on recrystallization but its results are applicable to any nucleation and growth transformation.

  11. Effect of non-random dispersal strategies on spatial coexistence mechanisms.

    Science.gov (United States)

    Amarasekare, Priyanga

    2010-01-01

    1. Random dispersal leads to spatial coexistence via two mechanisms (emigration-mediated and source-sink), both of which involve the movement of organisms from areas of higher to lower fitness. What is not known is whether such coexistence would occur if organisms dispersed non-randomly, using cues such as density and habitat quality to gauge fitness differences between habitats. Here, I conduct a comparative analysis of random and non-random dispersal strategies in a foodweb with a basal resource, top predator, and two intermediate consumers that exhibit a trade-off between competitive ability and predator susceptibility. 2. I find a striking contrast between density- and habitat-dependent dispersal in their effects on spatial coexistence. Dispersal in response to competitor and predator density facilitates coexistence while dispersal in response to habitat quality (resource productivity and predator pressure) inhibits it. Moreover, density-dependent dispersal changes species' distribution patterns from interspecific segregation to interspecific aggregation, while habitat-dependent dispersal preserves the interspecific segregation observed in the absence of dispersal. Under density-dependent dispersal, widespread spatial coexistence results in an overall decline in the abundance of the inferior competitor that is less susceptible to predation and an overall increase in the abundance of the superior competitor that is more susceptible to predation. Under habitat-dependent dispersal, restricted spatial coexistence results in species' abundances being essentially unchanged from those observed in the absence of dispersal. 3. A key outcome is that when the superior competitor moves in the direction of increasing fitness but the inferior competitor does not, spatial coexistence is possible in both resource-poor and resource-rich habitats. However, when the inferior competitor moves in the direction of increasing fitness but the superior competitor does not, spatial

  12. CLIPS based decision support system for water distribution networks

    Directory of Open Access Journals (Sweden)

    K. Sandeep

    2011-10-01

    Full Text Available The difficulty in knowledge representation of a water distribution network (WDN problem has contributed to the limited use of artificial intelligence (AI based expert systems (ES in the management of these networks. This paper presents a design of a Decision Support System (DSS that facilitates "on-demand'' knowledge generation by utilizing results of simulation runs of a suitably calibrated and validated hydraulic model of an existing aged WDN corresponding to emergent or even hypothetical but likely scenarios. The DSS augments the capability of a conventional expert system by integrating together the hydraulic modelling features with heuristics based knowledge of experts under a common, rules based, expert shell named CLIPS (C Language Integrated Production System. In contrast to previous ES, the knowledge base of the DSS has been designed to be dynamic by superimposing CLIPS on Structured Query Language (SQL. The proposed ES has an inbuilt calibration module that enables calibration of an existing (aged WDN for the unknown, and unobservable, Hazen-Williams C-values. In addition, the daily run and simulation modules of the proposed ES further enable the CLIPS inference engine to evaluate the network performance for any emergent or suggested test scenarios. An additional feature of the proposed design is that the DSS integrates computational platforms such as MATLAB, open source Geographical Information System (GIS, and a relational database management system (RDBMS working under the umbrella of the Microsoft Visual Studio based common user interface. The paper also discusses implementation of the proposed framework on a case study and clearly demonstrates the utility of the application as an able aide for effective management of the study network.

  13. a Bidirectional Reflectance Model for Non-Random Canopies.

    Science.gov (United States)

    Welles, Jonathan Mark

    The general array model (GAR) is extended to calculate bidirectional reflectance (reflectance as a function of angle of view and angle of illumination) of a plant stand. The new model (BIGAR) defines the plant canopy as one or more foliage-containing ellipsoids arranged in any desired pattern. Foliage is assumed randomly distributed within each ellipsoid, with a specified distribution of inclination angles and random azimuthal orientation distribution. A method of specifying sub-ellipsoids that contain foliage of varying properties is discussed. Foliage is assumed to scatter radiation in a Lambertian fashion. The soil bidirectional reflectance is modelled separately as a boundary condition. The reflectance of any given grid point within the plant stand is calculated from the incident radiation (direct beam, diffuse sky, and diffuse scattered from the soil and foliage) and a view weighting factor that is based upon how much of the view is occupied by that particular grid point. Integrating this over a large number of grid locations provides a prediction of the bidirectional reflectance. Model predictions are compared with measurements in corn and soybean canopies at three stages of growth. The model does quite well in predicting the general shape and dynamics of the measured bidirectional reflectance factors, and rms errors are typically 10% to 15% (relative) of the integrated reflectance value. The effect of rows is evident in both the measurements and the model in the early part of the growing season. The presence of tassles in the corn may be the cause of unpredicted row effects later in the season. Predicted nadir reflectances are accurate for soybean, but are low for full cover corn. The presence of specular reflection causes the model to slightly underpredict reflectances looking toward the sun at large solar zenith angles.

  14. Incomplete categorical data design non-randomized response techniques for sensitive questions in surveys

    CERN Document Server

    Tian, Guo-Liang

    2013-01-01

    Respondents to survey questions involving sensitive information, such as sexual behavior, illegal drug usage, tax evasion, and income, may refuse to answer the questions or provide untruthful answers to protect their privacy. This creates a challenge in drawing valid inferences from potentially inaccurate data. Addressing this difficulty, non-randomized response approaches enable sample survey practitioners and applied statisticians to protect the privacy of respondents and properly analyze the gathered data.Incomplete Categorical Data Design: Non-Randomized Response Techniqu

  15. Synaptic signal streams generated by ex vivo neuronal networks contain non-random, complex patterns.

    Science.gov (United States)

    Lee, Sangmook; Zemianek, Jill M; Shultz, Abraham; Vo, Anh; Maron, Ben Y; Therrien, Mikaela; Courtright, Christina; Guaraldi, Mary; Yanco, Holly A; Shea, Thomas B

    2014-11-01

    Cultured embryonic neurons develop functional networks that transmit synaptic signals over multiple sequentially connected neurons as revealed by multi-electrode arrays (MEAs) embedded within the culture dish. Signal streams of ex vivo networks contain spikes and bursts of varying amplitude and duration. Despite the random interactions inherent in dissociated cultures, neurons are capable of establishing functional ex vivo networks that transmit signals among synaptically connected neurons, undergo developmental maturation, and respond to exogenous stimulation by alterations in signal patterns. These characteristics indicate that a considerable degree of organization is an inherent property of neurons. We demonstrate herein that (1) certain signal types occur more frequently than others, (2) the predominant signal types change during and following maturation, (3) signal predominance is dependent upon inhibitory activity, and (4) certain signals preferentially follow others in a non-reciprocal manner. These findings indicate that the elaboration of complex signal streams comprised of a non-random distribution of signal patterns is an emergent property of ex vivo neuronal networks.

  16. Execution time support for scientific programs on distributed memory machines

    Science.gov (United States)

    Berryman, Harry; Saltz, Joel; Scroggs, Jeffrey

    1990-01-01

    Optimizations are considered that are required for efficient execution of code segments that consists of loops over distributed data structures. The PARTI (Parallel Automated Runtime Toolkit at ICASE) execution time primitives are designed to carry out these optimizations and can be used to implement a wide range of scientific algorithms on distributed memory machines. These primitives allow the user to control array mappings in a way that gives an appearance of shared memory. Computations can be based on a global index set. Primitives are used to carry out gather and scatter operations on distributed arrays. Communications patterns are derived at runtime, and the appropriate send and receive messages are automatically generated.

  17. Intelligent decision support algorithm for distribution system restoration.

    Science.gov (United States)

    Singh, Reetu; Mehfuz, Shabana; Kumar, Parmod

    2016-01-01

    Distribution system is the means of revenue for electric utility. It needs to be restored at the earliest if any feeder or complete system is tripped out due to fault or any other cause. Further, uncertainty of the loads, result in variations in the distribution network's parameters. Thus, an intelligent algorithm incorporating hybrid fuzzy-grey relation, which can take into account the uncertainties and compare the sequences is discussed to analyse and restore the distribution system. The simulation studies are carried out to show the utility of the method by ranking the restoration plans for a typical distribution system. This algorithm also meets the smart grid requirements in terms of an automated restoration plan for the partial/full blackout of network.

  18. Functional redundancy patterns reveal non-random assembly rules in a species-rich marine assemblage.

    Directory of Open Access Journals (Sweden)

    Nicolas Guillemot

    Full Text Available The relationship between species and the functional diversity of assemblages is fundamental in ecology because it contains key information on functional redundancy, and functionally redundant ecosystems are thought to be more resilient, resistant and stable. However, this relationship is poorly understood and undocumented for species-rich coastal marine ecosystems. Here, we used underwater visual censuses to examine the patterns of functional redundancy for one of the most diverse vertebrate assemblages, the coral reef fishes of New Caledonia, South Pacific. First, we found that the relationship between functional and species diversity displayed a non-asymptotic power-shaped curve, implying that rare functions and species mainly occur in highly diverse assemblages. Second, we showed that the distribution of species amongst possible functions was significantly different from a random distribution up to a threshold of ∼90 species/transect. Redundancy patterns for each function further revealed that some functions displayed fast rates of increase in redundancy at low species diversity, whereas others were only becoming redundant past a certain threshold. This suggested non-random assembly rules and the existence of some primordial functions that would need to be fulfilled in priority so that coral reef fish assemblages can gain a basic ecological structure. Last, we found little effect of habitat on the shape of the functional-species diversity relationship and on the redundancy of functions, although habitat is known to largely determine assemblage characteristics such as species composition, biomass, and abundance. Our study shows that low functional redundancy is characteristic of this highly diverse fish assemblage, and, therefore, that even species-rich ecosystems such as coral reefs may be vulnerable to the removal of a few keystone species.

  19. The Impact of an Instructional Intervention Designed to Support Development of Stochastic Understanding of Probability Distribution

    Science.gov (United States)

    Conant, Darcy Lynn

    2013-01-01

    Stochastic understanding of probability distribution undergirds development of conceptual connections between probability and statistics and supports development of a principled understanding of statistical inference. This study investigated the impact of an instructional course intervention designed to support development of stochastic…

  20. The Impact of an Instructional Intervention Designed to Support Development of Stochastic Understanding of Probability Distribution

    Science.gov (United States)

    Conant, Darcy Lynn

    2013-01-01

    Stochastic understanding of probability distribution undergirds development of conceptual connections between probability and statistics and supports development of a principled understanding of statistical inference. This study investigated the impact of an instructional course intervention designed to support development of stochastic…

  1. Raster Data Partitioning for Supporting Distributed GIS Processing

    Science.gov (United States)

    Nguyen Thai, B.; Olasz, A.

    2015-08-01

    In the geospatial sector big data concept also has already impact. Several studies facing originally computer science techniques applied in GIS processing of huge amount of geospatial data. In other research studies geospatial data is considered as it were always been big data (Lee and Kang, 2015). Nevertheless, we can prove data acquisition methods have been improved substantially not only the amount, but the resolution of raw data in spectral, spatial and temporal aspects as well. A significant portion of big data is geospatial data, and the size of such data is growing rapidly at least by 20% every year (Dasgupta, 2013). The produced increasing volume of raw data, in different format, representation and purpose the wealth of information derived from this data sets represents only valuable results. However, the computing capability and processing speed rather tackle with limitations, even if semi-automatic or automatic procedures are aimed on complex geospatial data (Kristóf et al., 2014). In late times, distributed computing has reached many interdisciplinary areas of computer science inclusive of remote sensing and geographic information processing approaches. Cloud computing even more requires appropriate processing algorithms to be distributed and handle geospatial big data. Map-Reduce programming model and distributed file systems have proven their capabilities to process non GIS big data. But sometimes it's inconvenient or inefficient to rewrite existing algorithms to Map-Reduce programming model, also GIS data can not be partitioned as text-based data by line or by bytes. Hence, we would like to find an alternative solution for data partitioning, data distribution and execution of existing algorithms without rewriting or with only minor modifications. This paper focuses on technical overview of currently available distributed computing environments, as well as GIS data (raster data) partitioning, distribution and distributed processing of GIS algorithms

  2. Retroviral integration process in the human genome: is it really non-random? A new statistical approach.

    Directory of Open Access Journals (Sweden)

    Alessandro Ambrosi

    Full Text Available Retroviral vectors are widely used in gene therapy to introduce therapeutic genes into patients' cells, since, once delivered to the nucleus, the genes of interest are stably inserted (integrated into the target cell genome. There is now compelling evidence that integration of retroviral vectors follows non-random patterns in mammalian genome, with a preference for active genes and regulatory regions. In particular, Moloney Leukemia Virus (MLV-derived vectors show a tendency to integrate in the proximity of the transcription start site (TSS of genes, occasionally resulting in the deregulation of gene expression and, where proto-oncogenes are targeted, in tumor initiation. This has drawn the attention of the scientific community to the molecular determinants of the retroviral integration process as well as to statistical methods to evaluate the genome-wide distribution of integration sites. In recent approaches, the observed distribution of MLV integration distances (IDs from the TSS of the nearest gene is assumed to be non-random by empirical comparison with a random distribution generated by computational simulation procedures. To provide a statistical procedure to test the randomness of the retroviral insertion pattern, we propose a probability model (Beta distribution based on IDs between two consecutive genes. We apply the procedure to a set of 595 unique MLV insertion sites retrieved from human hematopoietic stem/progenitor cells. The statistical goodness of fit test shows the suitability of this distribution to the observed data. Our statistical analysis confirms the preference of MLV-based vectors to integrate in promoter-proximal regions.

  3. Supporting the development of shared understanding in distributed design teams

    DEFF Research Database (Denmark)

    Cash, Philip; Dekoninck, Elies A; Ahmed-Kristensen, Saeema

    2017-01-01

    Distributed teams are an increasingly common feature of engineeringdesign work. One key factor in the success of these teams isthe development of short- and longer-term shared understanding.A lack of shared understanding has been recognized as a significantchallenge, particularly in the context o...

  4. Fast demand response in support of the active distribution network

    NARCIS (Netherlands)

    MacDougall, P.; Heskes, P.; Crolla, P.; Burt, G.; Warmer, C.

    2013-01-01

    Demand side management has traditionally been investigated for "normal" operation services such as balancing and congestion management. However they potentially could be utilized for Distributed Network Operator (DNO) services. This paper investigates and validates the use of a supply and demand res

  5. Distributed user support and the Gemini Observatory help desk

    Science.gov (United States)

    Chan, Simon; Puxley, Phil J.

    2000-07-01

    The Gemini Observatory HelpDesk was activated early in 2000 to aid in the rapid and accurate resolution of queries concerning the Gemini telescopes and their capabilities. This system co- ordinates user support amongst staff within the Observatory and at National Offices in each partner country. The HelpDesk is based on a commercial product from Remedy Corporation that logs, tracks, forwards and escalates queries and self- generates a knowledgebase of previously asked questions. Timestamping of these events in the life cycle of a request and analysis of associated information provides valuable feedback on the static web content and performance of user support.

  6. A hydraulic distribution device of a powered support section

    Energy Technology Data Exchange (ETDEWEB)

    Zhuravlev, R.P.; Barinov, V.S.; Demidovich, Z.A.; Fedorov, L.I.; Kozhukhov, L.F.; Mosunov, Yu.Ya.

    1981-01-30

    The goal of this invention is to reduce the working time for manual control in the process of bracing a hydraulic prop and complete use of the working pressure of the support's hydraulic system to perform initial bracing of the hydraulic prop. To achieve this goal, the device has a reflux valve with a locking element and a choke, the latter situated between the piston and rod chambers; the floating piston is made with a stop which interacts with the motion limiter, while the rod of the floating piston has a pusher which interacts with the locking element of the reflux valve. Use of the hydraulic device of this design in powered supports during their operation under various mining conditions significantly raises the operating life of hydraulic supports and hydraulic distributors, while lowering the total complex's down time. Automatic positioning of the predetermined amount of initial spacing shortens the time in which the operator handles the support sections. The operator uses the time available to perform succeeding operations (transition to the next control panel, unloading, and transfer).

  7. Network-aware support for mobile distributed teams

    NARCIS (Netherlands)

    Kleij, R. van der; Jong, A. de; Brake, G.M. te; Greefe, T.E.

    2009-01-01

    An experiment evaluated network-aware support to increase understanding of the factors that are important for successful teamwork in mobile geographically dispersed teams of first responders. Participants performed a simulated search and rescue team task and were equipped with a digitized map and

  8. Network-aware support for mobile distributed teams

    NARCIS (Netherlands)

    Kleij, R. van der; Jong, A. de; Brake, G.M. te; Greefe, T.E.

    2009-01-01

    An experiment evaluated network-aware support to increase understanding of the factors that are important for successful teamwork in mobile geographically dispersed teams of first responders. Participants performed a simulated search and rescue team task and were equipped with a digitized map and re

  9. Discovering non-random segregation of sister chromatids: The naïve treatment of a premature discovery

    Directory of Open Access Journals (Sweden)

    Karl G. Lark

    2013-02-01

    Full Text Available The discovery of non-random chromosome segregation is discussed from the perspective of what was known in1965 and1966. The distinction between daughter, parent or grandparent strands of DNA was developed in a bacterial system and led to the discovery that multiple copies of DNA elements of bacteria are not distributed randomly with respect to the age of the template strand. Experiments with higher eukaryotic cells demonstrated that during mitosis Mendel’s laws were violated; and the initial serendipitous choice of eukaryotic cell system led to the striking example of non-random segregation of parent and grand-parent DNA template strands in primary cultures of cells derived from mouse embryos. Attempts to extrapolate these findings to established TC lines demonstrated that the property could be lost. Experiments using plant root tips demonstrated that the phenomenon exists in plants and that it was, at some level, under genetic control. Despite publication in major journals and symposia (Lark et al. (1966a; Lark (1967a; 1967b; 1969, 1969a; 1969b the potential implications of these findings were ignored for several decades. Here we explore possible reasons for the pre-maturity (Stent, 1972 of this discovery.

  10. Legal Issues Supporting Production and Distribution of Biotech Products

    Directory of Open Access Journals (Sweden)

    Elena V. Luneva

    2016-11-01

    Full Text Available in article, on basis of works of Russian and foreign academic lawyers, biologists, microbiologists, zoologists, genetics and also representatives of other sciences of natural-science branch, is researched legal relationship on production and distribution of biotechnological products in the Russian Federation, The law provision in considered sphere is highly unified. Peculiarities of legal mode of biotechnological products are not taken into account. Specification and differentiation of legal regulation of relations on production and distribution of biotechnological products is required. Absence of legal definition of "biotechnology" leads to ambiguity of their legal mode and low efficiency of legal regulation. Reasonability of development of separate legal classification by potential hazard of gene-engineering activity for ecological systems is grounded. Necessity of assignment of legal measures directed on development of biotechnologies and active involvement of biotechnological methods into diverse segments of economic and social provision of human is detected. Conclusion is made about the fact that proportion of stimulation and limitation in legal regulation of production and distribution of biotechnological products should be such that maximally complete application of achievements and developments of biotechnology in production with minimal risk of adverse impact on human and natural environment may occur.

  11. Non-random structures in universal compression and the Fermi paradox

    Science.gov (United States)

    Gurzadyan, A. V.; Allahverdyan, A. E.

    2016-02-01

    We study the hypothesis of information panspermia assigned recently among possible solutions of the Fermi paradox ("where are the aliens?"). It suggests that the expenses of alien signaling can be significantly reduced, if their messages contained compressed information. To this end we consider universal compression and decoding mechanisms ( e.g. the Lempel-Ziv-Welch algorithm) that can reveal non-random structures in compressed bit strings. The efficiency of the Kolmogorov stochasticity parameter for detection of non-randomness is illustrated, along with the Zipf's law. The universality of these methods, i.e. independence from data details, can be principal in searching for intelligent messages.

  12. Non-random structures in universal compression and the Fermi paradox

    CERN Document Server

    Gurzadyan, A V

    2016-01-01

    We study the hypothesis of information panspermia assigned recently among possible solutions of the Fermi paradox ("where are the aliens?"). It suggests that the expenses of alien signaling can be significantly reduced, if their messages contain compressed information. To this end we consider universal compression and decoding mechanisms (e.g. the Lempel-Ziv-Welch algorithm) that can reveal non-random structures in compressed bit strings. The efficiency of Kolmogorov stochasticity parameter for detection of non-randomness is illustrated, along with the Zipf's law. The universality of these methods, i.e. independence on data details, can be principal in searching for intelligent messages.

  13. Experimental Support for a Categorical Compositional Distributional Model of Meaning

    CERN Document Server

    Grefenstette, Edward

    2011-01-01

    Modelling compositional meaning for sentences using empirical distributional methods has been a challenge for computational linguists. We implement the abstract categorical model of Coecke et al. (arXiv:1003.4394v1 [cs.CL]) using data from the BNC and evaluate it. The implementation is based on unsupervised learning of matrices for relational words and applying them to the vectors of their arguments. The evaluation is based on the word disambiguation task developed by Mitchell and Lapata (2008) for intransitive sentences, and on a similar new experiment designed for transitive sentences. Our model matches the results of its competitors in the first experiment, and betters them in the second. The general improvement in results with increase in syntactic complexity showcases the compositional power of our model.

  14. Technology to support a distributed digital library for astronomy

    Science.gov (United States)

    Biemesderfer, C. D.

    1996-12-01

    The integrated electronic resource that is forming in the astronomical community is a functional distributed digital library. As the balance of the literature comes on-line over the next year, and as more organizations seek to make data and other resources available on the Internet, ad hoc agreements among groups will give way to de facto standards. In our effort to extend the knowledge gained in our work on the electronic ApJ, we are engaged in an initiative to collaborate with other publishers and information distributors to utilize existing tools so that disparate collections may interoperate. We expect to devise effective operating conventions, and to articulate standard means for making valuable, archival information accessible on the net, reliably and for the long term.

  15. A scheme for supporting distributed data structures on multicomputers

    Science.gov (United States)

    Hiranandani, Seema; Saltz, Joel; Berryman, Harry; Mehrotra, Piyush

    1990-01-01

    A data migration mechanism is proposed that allows an explicit and controlled mapping of data to memory. While read or write copies of each data element can be assigned to any processor's memory, longer term storage of each data element is assigned to a specific location in the memory of a particular processor. The proposed integration of a data migration scheme with a compiler is able to eliminate the migration of unneeded data that can occur in multiprocessor paging or caching. The overhead of adjudicating multiple concurrent writes to the same page or cache line is also eliminated. Data is presented that suggests that the scheme may be a pratical method for efficiently supporting data migration.

  16. Value sensitive design of automated workload distribution support for traffic control teams

    NARCIS (Netherlands)

    Harbers, M.; Neerincx, M.A.

    2014-01-01

    This paper studies the effects of automated support for workload distribution in traffic control teams on human values such as security, autonomy and privacy. The paper describes a workshop in which the support system's stakeholders, their values, and the effects of the support system on these value

  17. Use of Grid Tools to Support CMS Distributed Analysis

    CERN Document Server

    Fanfani, A; Anjum, A; Barrass, T; Bonacorsi, D; Bunn, J; Corvo, M; Darmenov, N; De Filippis, N; Donno, F; Donvito, G; Eulisse, G; Fanzago, F; Filine, A; Grandi, C; Hernández, J M; Innocente, V; Jan, A; Lacaprara, S; Legrand, I; Metson, S; Newman, H; Silvestris, L; Steenberg, C; Stockinger, H; Taylor, L; Thomas, M; Tuura, L; Van Lingen, F; Wildish, T

    2004-01-01

    In order to prepare the Physic Technical Design Report, due by end of 2005, the CMS experiment needs to simulate, reconstruct and anlayse about 100 million events, corresponding to more than 200 TB of data. The data will be distributed to several Computing Centres. In order to provide access to the whole data sample to all the world-wide dispersed physicists, CMS is developing a layer of software that uses the grid tools provided by the LCG project to gain access to data and resources and that aims to provide physicists with a user friendly interface for submitting analysis jobs. The GRID tools used are both those already available in the LCG-2 release and those being developed in gain access to data and resources and that aims to provide physicists with a user friendly interface for submitting analysis jobs. The GRID tools used are both those already available in the LCG-2 release and those being developed in the framework of the ARDA project. This work describes the current status and the future development...

  18. Evidence for non-random distribution of Fc gamma receptor genotype combinations

    NARCIS (Netherlands)

    van der Pol, WL; Jansen, MD; Sluiter, WJ; van de Sluis, B; Leppers-van de Straat, FGJ; Kobayashi, T; Westendorp, RGJ; Huizinga, TWJ; van de Winkel, JGJ

    2003-01-01

    Human IgG receptors (FcgammaR) display considerable heterogeneity, and are crucial immune response modulating molecules. FcgammaRIIA, FcgammaRIIIA, and FcgammaRIIIB display functional biallelic polymorphisms. FcgammaR polymorphisms have been found associated with susceptibility to infectious and aut

  19. Overcoming barriers to scheduling embedded generation to support distribution networks

    Energy Technology Data Exchange (ETDEWEB)

    Wright, A.J.; Formby, J.R.

    2000-07-01

    Current scheduling of embedded generation for distribution in the UK is limited and patchy. Some DNOs actively schedule while others do none. The literature on the subject is mainly about accommodating volatile wind output, and optimising island systems, for both cost of supply and network stability. The forthcoming NETA will lower prices, expose unpredictable generation to imbalance markets and could introduce punitive constraint payments on DNOs, but at the same time create a dynamic market for both power and ancillary services from embedded generators. Most renewable generators either run as base load (e.g. waste ) or according to the vagaries of the weather (e.g. wind, hydro), so offer little scope for scheduling other than 'off'. CHP plant is normally heat- led for industrial processes or building needs, but supplementary firing or thermal storage often allow considerable scope for scheduling. Micro-CHP with thermal storage could provide short-term scheduling, but tends to be running anyway during the evening peak. Standby generation appears to be ideal for scheduling, but in practice operators may be unwilling to run parallel with the network, and noise and pollution problems may preclude frequent operation. Statistical analysis can be applied to calculate the reliability of several generators compared to one; with a large number of generators such as micro-CHP reliability of a proportion of load is close to unity. The type of communication for generation used will depend on requirements for bandwidth, cost, reliability and whether it is bundled with other services. With high levels of deeply embedded, small-scale generation using induction machines, voltage control and black start capability will become important concerns on 11 kV and LV networks. This will require increased generation monitoring and remote control of switchgear. Examples of cost benefits from scheduling are given, including deferred reinforcement, increased exports on non

  20. Supporting users through integrated retrieval, processing, and distribution systems at the Land Processes Distributed Active Archive Center

    Science.gov (United States)

    Kalvelage, Thomas A.; Willems, Jennifer

    2005-01-01

    The US Geological Survey's EROS Data Center (EDC) hosts the Land Processes Distributed Active Archive Center (LP DAAC). The LP DAAC supports NASA's Earth Observing System (EOS), which is a series of polar-orbiting and low inclination satellites for long-term global observations of the land surface, biosphere, solid Earth, atmosphere, and oceans. The EOS Data and Information Systems (EOSDIS) was designed to acquire, archive, manage and distribute Earth observation data to the broadest possible user community.

  1. Ambient Learning Displays - Distributed Mixed Reality Information Mash-ups to support Ubiquitous Learning

    NARCIS (Netherlands)

    Börner, Dirk

    2010-01-01

    Börner, D. (2010, 19-21 March). Ambient Learning Displays Distributed Mixed Reality Information Mash-ups to support Ubiquitous Learning. Presented at the IADIS International Conference Mobile Learning 2010, Porto, Portugal.

  2. Ambient Learning Displays - Distributed Mixed Reality Information Mash-ups to support Ubiquitous Learning

    NARCIS (Netherlands)

    Börner, Dirk

    2010-01-01

    Börner, D. (2010, 19-21 March). Ambient Learning Displays Distributed Mixed Reality Information Mash-ups to support Ubiquitous Learning. Presented at the IADIS International Conference Mobile Learning 2010, Porto, Portugal.

  3. Dutch gas distribution grid goes green: decision support tool for local biogas utilization

    NARCIS (Netherlands)

    Weidenaar, T.D.

    2011-01-01

    A Decision Support Tool (DST) has been developed that will aid Distribution Service Operators (DSOs) in their decision making process on which investments to make in the gas distribution grid in order to facilitate the use of biogas. The DST considers both the conversion of biogas to electricity as

  4. Mechanism of financial support of education: legislative basis of power distribution

    Directory of Open Access Journals (Sweden)

    O. S. Kotsovska

    2014-11-01

    Full Text Available The article studies the legislative basis of power distribution as a basic component of the mechanism of financial support of education at the regional level. Budgetary expenditure on education has been analyzed. It has been grounded and proposed to transfer the authority of financial support of education to appropriate regional and district administrations within the frameworks of decentralisation.

  5. Managing to Change: The Wharton School's Distributed Staff Model for Computing Support.

    Science.gov (United States)

    Eleey, Michael

    1993-01-01

    The University of Pennsylvania's Wharton School introduced a "distributed" organization for managing computing support services. The hybrid structure combined elements of centralized computing and departmental computing by placing computing personnel in the departments, under central management. The program covers a wide range of support services…

  6. Checklists of Methodological Issues for Review Authors to Consider When Including Non-Randomized Studies in Systematic Reviews

    Science.gov (United States)

    Wells, George A.; Shea, Beverley; Higgins, Julian P. T.; Sterne, Jonathan; Tugwell, Peter; Reeves, Barnaby C.

    2013-01-01

    Background: There is increasing interest from review authors about including non-randomized studies (NRS) in their systematic reviews of health care interventions. This series from the Ottawa Non-Randomized Studies Workshop consists of six papers identifying methodological issues when doing this. Aim: To format the guidance from the preceding…

  7. Meta-analyses including non-randomized studies of therapeutic interventions: a methodological review

    Directory of Open Access Journals (Sweden)

    Timor Faber

    2016-03-01

    Full Text Available Abstract Background There is an increasing number of meta-analyses including data from non-randomized studies for therapeutic evaluation. We aimed to systematically assess the methods used in meta-analyses including non-randomized studies evaluating therapeutic interventions. Methods For this methodological review, we searched MEDLINE via PubMed, from January 1, 2013 to December 31, 2013 for meta-analyses including at least one non-randomized study evaluating therapeutic interventions. Etiological assessments and meta-analyses with no comparison group were excluded. Two reviewers independently assessed the general characteristics and key methodological components of the systematic review process and meta-analysis methods. Results One hundred eighty eight meta-analyses were selected: 119 included both randomized controlled trials (RCTs and non-randomized studies of interventions (NRSI and 69 only NRSI. Half of the meta-analyses (n = 92, 49 % evaluated non-pharmacological interventions. “Grey literature” was searched for 72 meta-analyses (38 %. An assessment of methodological quality or risk of bias was reported in 135 meta-analyses (72 % but this assessment considered the risk of confounding bias in only 33 meta-analyses (18 %. In 130 meta-analyses (69 %, the design of each NRSI was not clearly specified. In 131 (70 %, whether crude or adjusted estimates of treatment effect for NRSI were combined was unclear or not reported. Heterogeneity across studies was assessed in 182 meta-analyses (97 % and further explored in 157 (84 %. Reporting bias was assessed in 127 (68 %. Conclusions Some key methodological components of the systematic review process—search for grey literature, description of the type of NRSI included, assessment of risk of confounding bias and reporting of whether crude or adjusted estimates were combined—are not adequately carried out or reported in meta-analyses including NRSI.

  8. Calculation of force distribution for a periodically supported beam subjected to moving loads

    Science.gov (United States)

    Hoang, T.; Duhamel, D.; Foret, G.; Yin, H. P.; Joyez, P.; Caby, R.

    2017-02-01

    In this study, a novel model for a periodically supported beam subjected to moving loads was developed using a periodicity condition on reaction forces. This condition, together with Fourier transforms and Dirac combs, forms a relation between the beam displacement and support reaction forces. This relation explains the force distribution at the supports, and holds for any type of support and foundation behaviors. Based on this relation, a system equivalence for a periodically supported beam is presented in this paper. An application to non-ballasted viscoelastic supports is presented as an example and the results clearly match the existing model. Next, an approximation of real-time responses was developed for the moving loads as periodic series. The comparison shows that this approximation can be used for a limited number of loads if the distances between loads are sufficiently large. The system equivalence for a periodically supported beam is efficient for supports with linear behavior, and could be extended to other behaviors.

  9. The European ALMA Regional Centre Network: A Geographically Distributed User Support Model

    CERN Document Server

    Hatziminaoglou, Evanthia; Andreani, Paola; Barta, Miroslav; Bertoldi, Frank; Brand, Jan; Gueth, Frederique; Hogerheijde, Michiel; Maercker, Matthias; Massardi, Marcella; Muehle, Stefanie; Muxlow, Thomas; Richards, Anita; Schilke, Peter; Tilanus, Remo; Vlemmings, Wouter; Afonso, Jose; Messias, Hugo

    2016-01-01

    In recent years there has been a paradigm shift from centralised to geographically distributed resources. Individual entities are no longer able to host or afford the necessary expertise in-house, and, as a consequence, society increasingly relies on widespread collaborations. Although such collaborations are now the norm for scientific projects, more technical structures providing support to a distributed scientific community without direct financial or other material benefits are scarce. The network of European ALMA Regional Centre (ARC) nodes is an example of such an internationally distributed user support network. It is an organised effort to provide the European ALMA user community with uniform expert support to enable optimal usage and scientific output of the ALMA facility. The network model for the European ARC nodes is described in terms of its organisation, communication strategies and user support.

  10. Distribution of Fullerene Nanoparticles between Water and Solid Supported Lipid Membranes: Thermodynamics and Effects of Membrane Composition on Distribution.

    Science.gov (United States)

    Ha, Yeonjeong; Katz, Lynn E; Liljestrand, Howard M

    2015-12-15

    The distribution coefficient (Klipw) of fullerene between solid supported lipid membranes (SSLMs) and water was examined using different lipid membrane compositions. Klipw of fullerene was significantly higher with a cationic lipid membrane compared to that with a zwitterionic or anionic lipid membrane, potentially due to the strong interactions between negative fullerene dispersions and positive lipid head groups. The higher Klipw for fullerene distribution to ternary lipid mixture membranes was attributed to an increase in the interfacial surface area of the lipid membrane resulting from phase separation. These results imply that lipid composition can be a critical factor that affects bioconcentration of fullerene. Distribution of fullerene into zwitterionic unsaturated lipid membranes was dominated by the entropy contribution (ΔS) and the process was endothermic (ΔH > 0). This result contrasts the partitioning thermodynamics of highly and moderately hydrophobic chemicals indicating that the lipid-water distribution mechanism of fullerene may be different from that of molecular level chemicals. Potential mechanisms for the distribution of fullerene that may explain these differences include adsorption on the lipid membrane surfaces and partitioning into the center of lipid membranes (i.e., absorption).

  11. Active and reactive power support of MV distribution systems using battery energy storage

    DEFF Research Database (Denmark)

    Wang, Jiawei; Hashemi Toghroljerdi, Seyedmostafa; You, Shi

    2017-01-01

    Adoption of Battery Energy Storage Systems (BESSs) for provision of grid services is increasing. This paper investigates the applications of BESS for the grid upgrade deferral and voltage support of Medium Voltage (MV) distribution systems. A BESS is modelled in Matlab/Simulink to perform peak load...... size for peak load shaving are investigated. The BESS annual lifetime degradation is also estimated using a rainflow counting algorithm. A reactive power support algorithm embedded with Q-U droop control is proposed in order to reduce the voltage drop in a part of 10 kV distribution network of Nordhavn...

  12. Meta-analysis of non-randomized studies in interventional cardiology: a critical appraisal

    Directory of Open Access Journals (Sweden)

    Eliano Pio Navarese

    2009-12-01

    Full Text Available Utilisation of meta-analysis is becoming more and more common in interventional cardiology. The aim of this statistical approach is to collect a large number of patients from randomized clinical studies and nonrandomized registries in order to obtain a pooled estimate of the results. Nevertheless, simply pooling these results without a correct methodological approach can easily lead to biased conclusions. In this report we analyse the possible methodological drawbacks of such an approach and we suggest a simplified check-list of items to be considered in the effort of building-up a meta-analysis from non-randomized studies.

  13. GMLC Hawaii Regional Partnership: Distributed Inverter-Based Grid Frequency Support

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, Austin; Hoke, Andy

    2017-05-04

    This presentation is part of a panel session at the IEEE ISGT conference on Grid Modernization Initiative projects. This segment of the panel session provides a brief overview of a Hawaii Regional Partnership project focusing grid frequency support from distributed resources on the fastest time scales.

  14. The Spatial Distribution and Morphology of Supported Nanocatalysts using Rutherford-Scattered Electron Imaging

    Science.gov (United States)

    Gai, Pratibha; Midgley, Paul; Weyland, Matthew; Thomas, John; Boyes, Edward

    2003-03-01

    Back-scattered electron (BSE) imaging, combined with scanning transmission electron microscopic (STEM) high angle annular dark field (HAADF) imaging, both using Rutherford-scattered electrons, are ideal in recording images of supported nanocatalysts. The incoherent scattering process ensures that images are ideal for electron tomography and the reconstruction of three-dimensional (3D) nanocatalyst distribution such as Pd on carbon.

  15. Ambient Learning Displays - Distributed Mixed Reality Information Mash-ups to support Ubiquitous Learning

    NARCIS (Netherlands)

    Börner, Dirk

    2012-01-01

    Börner, D. (2012). Ambient Learning Displays - Distributed Mixed Reality Information Mash-ups to support Ubiquitous Learning. 2012 IEEE Seventh International Conference on Wireless, Mobile and Ubiquitous Technology in Education (pp. 337-338). March, 27-30, 2012, Takamatsu, Japan: IEEE Computer Socie

  16. Ambient Learning Displays - Distributed Mixed Reality Information Mash-ups to support Ubiquitous Learning

    NARCIS (Netherlands)

    Börner, Dirk

    2012-01-01

    Börner, D. (2012). Ambient Learning Displays - Distributed Mixed Reality Information Mash-ups to support Ubiquitous Learning. 2012 IEEE Seventh International Conference on Wireless, Mobile and Ubiquitous Technology in Education (pp. 337-338). March, 27-30, 2012, Takamatsu, Japan: IEEE Computer

  17. Large Scale Solar Power Integration in Distribution Grids: PV Modelling, Voltage Support and Aggregation Studies

    NARCIS (Netherlands)

    Samadi, A.

    2014-01-01

    Long term supporting schemes for photovoltaic (PV) system installation have led to accommodating large numbers of PV systems within load pockets in distribution grids. High penetrations of PV systems can cause new technical challenges, such as voltage rise due to reverse power flow during light load

  18. DC++: distributed object-oriented system support on top of OSF DCE

    Science.gov (United States)

    Schill, A. B.; Mock, M. U.

    1993-12-01

    The OSF Distributed Computing Environment (DCE) is becoming an industry standard for open distributed computing. DCE only supports client/server-style applications based on the remote procedure call (RPC) communication model. The authors describe the design and implementation of an extended distributed object-oriented environment, DC++, on top of DCE. As opposed to RPC, it supports a uniform object model, location independent invocation of fine-grained objects, remote reference parameter passing, dynamic migration of objects between nodes, and C++ language integration. Moreover, the implementation is fully integrated with DCE, using DCE UUIDs for object identification, DCE threads for interobject concurrency, DCE RPC for remote object invocation, and the DCE Cell Directory Service (CDS) for optional retrieval of objects by name. An additional stub compiler enables automatic generation of C++-based object communication interfaces. Low-level parameter encoding is done by DCE RPC's stub generation facility using the C-based DCE interface definition language (IDL).

  19. Non-random biodiversity loss underlies predictable increases in viral disease prevalence.

    Science.gov (United States)

    Lacroix, Christelle; Jolles, Anna; Seabloom, Eric W; Power, Alison G; Mitchell, Charles E; Borer, Elizabeth T

    2014-03-06

    Disease dilution (reduced disease prevalence with increasing biodiversity) has been described for many different pathogens. Although the mechanisms causing this phenomenon remain unclear, the disassembly of communities to predictable subsets of species, which can be caused by changing climate, land use or invasive species, underlies one important hypothesis. In this case, infection prevalence could reflect the competence of the remaining hosts. To test this hypothesis, we measured local host species abundance and prevalence of four generalist aphid-vectored pathogens (barley and cereal yellow dwarf viruses) in a ubiquitous annual grass host at 10 sites spanning 2000 km along the North American West Coast. In laboratory and field trials, we measured viral infection as well as aphid fecundity and feeding preference on several host species. Virus prevalence increased as local host richness declined. Community disassembly was non-random: ubiquitous hosts dominating species-poor assemblages were among the most competent for vector production and virus transmission. This suggests that non-random biodiversity loss led to increased virus prevalence. Because diversity loss is occurring globally in response to anthropogenic changes, such work can inform medical, agricultural and veterinary disease research by providing insights into the dynamics of pathogens nested within a complex web of environmental forces.

  20. Non-random mate choice in humans: insights from a genome scan.

    Science.gov (United States)

    Laurent, R; Toupance, B; Chaix, R

    2012-02-01

    Little is known about the genetic factors influencing mate choice in humans. Still, there is evidence for non-random mate choice with respect to physical traits. In addition, some studies suggest that the Major Histocompatibility Complex may affect pair formation. Nowadays, the availability of high density genomic data sets gives the opportunity to scan the genome for signatures of non-random mate choice without prior assumptions on which genes may be involved, while taking into account socio-demographic factors. Here, we performed a genome scan to detect extreme patterns of similarity or dissimilarity among spouses throughout the genome in three populations of African, European American, and Mexican origins from the HapMap 3 database. Our analyses identified genes and biological functions that may affect pair formation in humans, including genes involved in skin appearance, morphogenesis, immunity and behaviour. We found little overlap between the three populations, suggesting that the biological functions potentially influencing mate choice are population specific, in other words are culturally driven. Moreover, whenever the same functional category of genes showed a significant signal in two populations, different genes were actually involved, which suggests the possibility of evolutionary convergences.

  1. United States Supports Distributed Wind Technology Improvements; NREL (National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    Sinclair, Karin

    2015-06-15

    This presentation provides information on the activities conducted through the Competitiveness Improvement Project (CIP), initiated in 2012 by the U.S. Department of Energy (DOE) and executed through the National Renewable Energy Laboratory (NREL) to support the distributed wind industry. The CIP provides research and development funding and technical support to improve distributed wind turbine technology and increase the competitiveness of U.S. small and midsize wind turbine manufacturers. Through this project, DOE/NREL assists U.S. manufacturers to lower the levelized cost of energy of wind turbines through component improvements, manufacturing process upgrades, and turbine testing. Ultimately, this support is expected to lead to turbine certification through testing to industry-recognized wind turbine performance and safety standards.

  2. Flexible voltage support control for three-phase distributed generation inverters under grid fault

    DEFF Research Database (Denmark)

    Camacho, Antonio; Castilla, Miguel; Miret, Jaume

    2013-01-01

    Operators describe the behavior of the energy source, regulating voltage limits and reactive power injection to remain connected and support the grid under fault. On the basis that different kinds of voltage sags require different voltage support strategies, a flexible control scheme for three phase grid......Ancillary services for distributed generation systems become a challenging issue to smartly integrate renewable energy sources into the grid. Voltage control is one of these ancillary services which can ride through and support the voltage under grid faults. Grid codes from the Transmission System...... connected inverters is proposed. In three phase balanced voltage sags, the inverter should inject reactive power in order to raise the voltage in all phases. In one or two phase faults, the main concern of the distributed generation inverter is to equalize voltages by reducing the negative symmetric...

  3. Distributional patterns of the Neotropical genus Thecomyia Perty (Diptera, Sciomyzidae and phylogenetic support

    Directory of Open Access Journals (Sweden)

    Amanda Ciprandi Pires

    2011-03-01

    Full Text Available Distributional patterns of the Neotropical genus Thecomyia Perty (Diptera, Sciomyzidae and phylogenetic support. The distributional pattern of the genus Thecomyia Perty, 1833 was defined using panbiogeographic tools, and analyzed based on the phylogeny of the group. This study sought to establish biogeographical homologies in the Neotropical region between different species of the genus, based on their distribution pattern and later corroboration through its phylogeny. Eight individual tracks and 16 generalized tracks were identified, established along nearly the entire swath of the Neotropics. Individual tracks are the basic units of a panbiogeographic study, and correspond to the hypothesis of minimum distribution of the organisms involved. The generalized tracks, obtained from the spatial congruence between two or more individual tracks, are important in the identification of smaller areas of endemism. Thus, we found evidence from the generalized tracks in support of previous classification for the Neotropical region. The Amazon domain is indicated as an area of outstanding importance in the diversification of the group, by the confluence of generalized tracks and biogeographic nodes in the region. Most of the generalized tracks and biogeographical nodes were congruent with the phylogenetic hypothesis of the genus, indicating support of the primary biogeographical homologies originally defined by the track analysis.

  4. SUPPORTED CATALYST WITHOUT EXTERNAL ELECTRON DONOR FOR PROPYLENE POLYMERIZATION Ⅱ. TACTICITY DISTRIBUTION AND MICROSTRUCTURE OF POLYPROPYLENE

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    Propylene was polymerized with a novel supported Ziegler-Natta catalyst containing 2,2-di-iso-butyl-1,3-dimethoxy-propane (DIBDMP) as internal donor and in the absence of external donor. The tacticity distribution of polypropylene was obtained by using temperature rising elution fractionation (TREF) technique and microstructure of fractions was studied with 13C-NMR. Compared with the catalyst without electron donor, this catalyst gives a considerably narrower tacticity distribution. Fractionation data demonstrate that DIBDMP shows better performance than aromatic diester DNBP (di-n-butyl phthalate). Chemically inverted propylene units and less stereoblockiness are found in the first fraction. Possible reasons for these were presented.

  5. Active Control of Thermostatic Loads for Economic and Technical Support to Distribution Grids

    DEFF Research Database (Denmark)

    Bhattarai, Bishnu Prasad; Mendaza, Iker Diaz de Cerio; Bak-Jensen, Birgitte

    2016-01-01

    Active control of electric water heaters (EWHs) is presented in this paper as a means of exploiting demand flexibility for supporting low-voltage (LV) distribution grids. A single-node model of an EWH is implemented in DIgSILENT PowerFactory using a thermal energy balancing equation and three...... of the energy band is done based on feeder loading to respect thermal grid constraints. Finally, a voltage-based control is implemented to provide real-time voltage support to the LV grids. Simulation results demonstrate the capability of the presented method to realize both economic and technical advantages...

  6. Non-random food-web assembly at habitat edges increases connectivity and functional redundancy.

    Science.gov (United States)

    Peralta, Guadalupe; Frost, Carol M; Didham, Raphael K; Rand, Tatyana A; Tylianakis, Jason M

    2017-04-01

    Habitat fragmentation dramatically alters the spatial configuration of landscapes, with the creation of artificial edges affecting community structure and dynamics. Despite this, it is not known how the different food webs in adjacent habitats assemble at their boundaries. Here we demonstrate that the composition and structure of herbivore-parasitoid food webs across edges between native and plantation forests are not randomly assembled from those of the adjacent communities. Rather, elevated proportions of abundant, interaction-generalist parasitoid species at habitat edges allowed considerable interaction rewiring, which led to higher linkage density and less modular networks, with higher parasitoid functional redundancy. This was despite high overlap in host composition between edges and interiors. We also provide testable hypotheses for how food webs may assemble between habitats with lower species overlap. In an increasingly fragmented world, non-random assembly of food webs at edges may increasingly affect community dynamics at the landscape level.

  7. Validation Support for Distributed Real-Time Embedded Systems in VDM++

    DEFF Research Database (Denmark)

    S. Fitzgerald, John; Gorm Larsen, Peter; Tjell, Simon

    2007-01-01

    We present a tool-supported approach to the validation of system-level timing properties in formal models of distributed real-time embedded systems. Our aim is to provide system architects with rapid feedback on the timing characteristics of alternative designs in the often volatile early stages...... of the development cycle. The approach extends the Vienna Development Method (VDM++), a formal objectoriented modeling language with facilities for describing real-time applications deployed over a distributed infrastructure. A new facility is proposed for stating and checking validation conjectures (assertions...... to visualise traces and validation conjecture violations. The approach and tool support are illustrated with a case study based on an in-car radio navigation system....

  8. Voltage Support Study of Smart PV Inverters on a High-Photovoltaic Penetration Utility Distribution Feeder

    Energy Technology Data Exchange (ETDEWEB)

    Ding, Fei; Pratt, Annabelle; Bialek, Tom; Bell, Frances; McCarty, Michael; Atef, Kahveh; Nagarajan, Adarsh; Gotseff, Peter

    2016-11-21

    This paper reports on tools and methodologies developed to study the impact of adding rooftop photovoltaic (PV) systems, with and without the ability to provide voltage support, on the voltage profile of distribution feeders. Simulation results are provided from a study of a specific utility feeder. The simulation model of the utility distribution feeder was built in OpenDSS and verified by comparing the simulated voltages to field measurements. First, we set all PV systems to operate at unity power factor and analyzed the impact on feeder voltages. Then we conducted multiple simulations with voltage support activated for all the smart PV inverters. These included different constant power factor settings and volt/VAR controls.

  9. Enabling to Apply XP Process in Distributed Development Environments with Tool Support

    Directory of Open Access Journals (Sweden)

    Ali Akbar Ansari

    2012-07-01

    Full Text Available The evaluation both in academic and industrial areas of the XP methodology has shown very good results if applied to small/medium co-localized working groups. In this paper, we described an approach that overcomes the XP constraint of collocation by introducing a process-support environment (called M.P.D.X.P that helps software development teams and solves the problems which arise when XP is carried out by distributed teams.

  10. Strategic Simulation - Support of Innovation and Operation in Distribution and production Networks

    DEFF Research Database (Denmark)

    Hansen, Mette Sanne

    Today’s business environment is characterized by global competition, changing conditions, and uncertainty. Many Western companies have responded by developing global distribution and production networks. The increasingly challenging business environment and the more complex structure of companies...... or quantitative approaches. Strategic simulation is the combination of narrative and numerical simulation and can be used as a tool to support strategic decision making by providing different scenarios in combination with computer modelling. The core of the combined simulation approach (CSA) is to make...

  11. Mobile Autonomous Sensing Unit (MASU: A Framework That Supports Distributed Pervasive Data Sensing

    Directory of Open Access Journals (Sweden)

    Esunly Medina

    2016-07-01

    Full Text Available Pervasive data sensing is a major issue that transverses various research areas and application domains. It allows identifying people’s behaviour and patterns without overwhelming the monitored persons. Although there are many pervasive data sensing applications, they are typically focused on addressing specific problems in a single application domain, making them difficult to generalize or reuse. On the other hand, the platforms for supporting pervasive data sensing impose restrictions to the devices and operational environments that make them unsuitable for monitoring loosely-coupled or fully distributed work. In order to help address this challenge this paper present a framework that supports distributed pervasive data sensing in a generic way. Developers can use this framework to facilitate the implementations of their applications, thus reducing complexity and effort in such an activity. The framework was evaluated using simulations and also through an empirical test, and the obtained results indicate that it is useful to support such a sensing activity in loosely-coupled or fully distributed work scenarios.

  12. Distributed Sensor Architecture for Intelligent Control that Supports Quality of Control and Quality of Service

    Directory of Open Access Journals (Sweden)

    Jose-Luis Poza-Lujan

    2015-02-01

    Full Text Available This paper is part of a study of intelligent architectures for distributed control and communications systems. The study focuses on optimizing control systems by evaluating the performance of middleware through quality of service (QoS parameters and the optimization of control using Quality of Control (QoC parameters. The main aim of this work is to study, design, develop, and evaluate a distributed control architecture based on the Data-Distribution Service for Real-Time Systems (DDS communication standard as proposed by the Object Management Group (OMG. As a result of the study, an architecture called Frame-Sensor-Adapter to Control (FSACtrl has been developed. FSACtrl provides a model to implement an intelligent distributed Event-Based Control (EBC system with support to measure QoS and QoC parameters. The novelty consists of using, simultaneously, the measured QoS and QoC parameters to make decisions about the control action with a new method called Event Based Quality Integral Cycle. To validate the architecture, the first five Braitenberg vehicles have been implemented using the FSACtrl architecture. The experimental outcomes, demonstrate the convenience of using jointly QoS and QoC parameters in distributed control systems.

  13. Distributed Sensor Architecture for Intelligent Control that Supports Quality of Control and Quality of Service

    Science.gov (United States)

    Poza-Lujan, Jose-Luis; Posadas-Yagüe, Juan-Luis; Simó-Ten, José-Enrique; Simarro, Raúl; Benet, Ginés

    2015-01-01

    This paper is part of a study of intelligent architectures for distributed control and communications systems. The study focuses on optimizing control systems by evaluating the performance of middleware through quality of service (QoS) parameters and the optimization of control using Quality of Control (QoC) parameters. The main aim of this work is to study, design, develop, and evaluate a distributed control architecture based on the Data-Distribution Service for Real-Time Systems (DDS) communication standard as proposed by the Object Management Group (OMG). As a result of the study, an architecture called Frame-Sensor-Adapter to Control (FSACtrl) has been developed. FSACtrl provides a model to implement an intelligent distributed Event-Based Control (EBC) system with support to measure QoS and QoC parameters. The novelty consists of using, simultaneously, the measured QoS and QoC parameters to make decisions about the control action with a new method called Event Based Quality Integral Cycle. To validate the architecture, the first five Braitenberg vehicles have been implemented using the FSACtrl architecture. The experimental outcomes, demonstrate the convenience of using jointly QoS and QoC parameters in distributed control systems. PMID:25723145

  14. Application of statistical distribution theory to launch-on-time for space construction logistic support

    Science.gov (United States)

    Morgenthaler, George W.

    1989-01-01

    The ability to launch-on-time and to send payloads into space has progressed dramatically since the days of the earliest missile and space programs. Causes for delay during launch, i.e., unplanned 'holds', are attributable to several sources: weather, range activities, vehicle conditions, human performance, etc. Recent developments in space program, particularly the need for highly reliable logistic support of space construction and the subsequent planned operation of space stations, large unmanned space structures, lunar and Mars bases, and the necessity of providing 'guaranteed' commercial launches have placed increased emphasis on understanding and mastering every aspect of launch vehicle operations. The Center of Space Construction has acquired historical launch vehicle data and is applying these data to the analysis of space launch vehicle logistic support of space construction. This analysis will include development of a better understanding of launch-on-time capability and simulation of required support systems for vehicle assembly and launch which are necessary to support national space program construction schedules. In this paper, the author presents actual launch data on unscheduled 'hold' distributions of various launch vehicles. The data have been supplied by industrial associate companies of the Center for Space Construction. The paper seeks to determine suitable probability models which describe these historical data and that can be used for several purposes such as: inputs to broader simulations of launch vehicle logistic space construction support processes and the determination of which launch operations sources cause the majority of the unscheduled 'holds', and hence to suggest changes which might improve launch-on-time. In particular, the paper investigates the ability of a compound distribution probability model to fit actual data, versus alternative models, and recommends the most productive avenues for future statistical work.

  15. Application of statistical distribution theory to launch-on-time for space construction logistic support

    Science.gov (United States)

    Morgenthaler, George W.

    1989-01-01

    The ability to launch-on-time and to send payloads into space has progressed dramatically since the days of the earliest missile and space programs. Causes for delay during launch, i.e., unplanned 'holds', are attributable to several sources: weather, range activities, vehicle conditions, human performance, etc. Recent developments in space program, particularly the need for highly reliable logistic support of space construction and the subsequent planned operation of space stations, large unmanned space structures, lunar and Mars bases, and the necessity of providing 'guaranteed' commercial launches have placed increased emphasis on understanding and mastering every aspect of launch vehicle operations. The Center of Space Construction has acquired historical launch vehicle data and is applying these data to the analysis of space launch vehicle logistic support of space construction. This analysis will include development of a better understanding of launch-on-time capability and simulation of required support systems for vehicle assembly and launch which are necessary to support national space program construction schedules. In this paper, the author presents actual launch data on unscheduled 'hold' distributions of various launch vehicles. The data have been supplied by industrial associate companies of the Center for Space Construction. The paper seeks to determine suitable probability models which describe these historical data and that can be used for several purposes such as: inputs to broader simulations of launch vehicle logistic space construction support processes and the determination of which launch operations sources cause the majority of the unscheduled 'holds', and hence to suggest changes which might improve launch-on-time. In particular, the paper investigates the ability of a compound distribution probability model to fit actual data, versus alternative models, and recommends the most productive avenues for future statistical work.

  16. A collaborative framework for Distributed Privacy-Preserving Support Vector Machine learning.

    Science.gov (United States)

    Que, Jialan; Jiang, Xiaoqian; Ohno-Machado, Lucila

    2012-01-01

    A Support Vector Machine (SVM) is a popular tool for decision support. The traditional way to build an SVM model is to estimate parameters based on a centralized repository of data. However, in the field of biomedicine, patient data are sometimes stored in local repositories or institutions where they were collected, and may not be easily shared due to privacy concerns. This creates a substantial barrier for researchers to effectively learn from the distributed data using machine learning tools like SVMs. To overcome this difficulty and promote efficient information exchange without sharing sensitive raw data, we developed a Distributed Privacy Preserving Support Vector Machine (DPP-SVM). The DPP-SVM enables privacy-preserving collaborative learning, in which a trusted server integrates "privacy-insensitive" intermediary results. The globally learned model is guaranteed to be exactly the same as learned from combined data. We also provide a free web-service (http://privacy.ucsd.edu:8080/ppsvm/) for multiple participants to collaborate and complete the SVM-learning task in an efficient and privacy-preserving manner.

  17. Issues in ATM Support of High-Performance, Geographically Distributed Computing

    Science.gov (United States)

    Claus, Russell W.; Dowd, Patrick W.; Srinidhi, Saragur M.; Blade, Eric D.G

    1995-01-01

    This report experimentally assesses the effect of the underlying network in a cluster-based computing environment. The assessment is quantified by application-level benchmarking, process-level communication, and network file input/output. Two testbeds were considered, one small cluster of Sun workstations and another large cluster composed of 32 high-end IBM RS/6000 platforms. The clusters had Ethernet, fiber distributed data interface (FDDI), Fibre Channel, and asynchronous transfer mode (ATM) network interface cards installed, providing the same processors and operating system for the entire suite of experiments. The primary goal of this report is to assess the suitability of an ATM-based, local-area network to support interprocess communication and remote file input/output systems for distributed computing.

  18. Optimal Coordinated EV Charging with Reactive Power Support in Constrained Distribution Grids

    Energy Technology Data Exchange (ETDEWEB)

    Paudyal, Sumit; Ceylan, Oğuzhan; Bhattarai, Bishnu P.; Myers, Kurt S.

    2017-07-01

    Electric vehicle (EV) charging/discharging can take place in any P-Q quadrants, which means EVs could support reactive power to the grid while charging the battery. In controlled charging schemes, distribution system operator (DSO) coordinates with the charging of EV fleets to ensure grid’s operating constraints are not violated. In fact, this refers to DSO setting upper bounds on power limits for EV charging. In this work, we demonstrate that if EVs inject reactive power into the grid while charging, DSO could issue higher upper bounds on the active power limits for the EVs for the same set of grid constraints. We demonstrate the concept in an 33-node test feeder with 1,500 EVs. Case studies show that in constrained distribution grids in coordinated charging, average costs of EV charging could be reduced if the charging takes place in the fourth P-Q quadrant compared to charging with unity power factor.

  19. The StratusLab cloud distribution: Use-cases and support for scientific applications

    Science.gov (United States)

    Floros, E.

    2012-04-01

    The StratusLab project is integrating an open cloud software distribution that enables organizations to setup and provide their own private or public IaaS (Infrastructure as a Service) computing clouds. StratusLab distribution capitalizes on popular infrastructure virtualization solutions like KVM, the OpenNebula virtual machine manager, Claudia service manager and SlipStream deployment platform, which are further enhanced and expanded with additional components developed within the project. The StratusLab distribution covers the core aspects of a cloud IaaS architecture, namely Computing (life-cycle management of virtual machines), Storage, Appliance management and Networking. The resulting software stack provides a packaged turn-key solution for deploying cloud computing services. The cloud computing infrastructures deployed using StratusLab can support a wide range of scientific and business use cases. Grid computing has been the primary use case pursued by the project and for this reason the initial priority has been the support for the deployment and operation of fully virtualized production-level grid sites; a goal that has already been achieved by operating such a site as part of EGI's (European Grid Initiative) pan-european grid infrastructure. In this area the project is currently working to provide non-trivial capabilities like elastic and autonomic management of grid site resources. Although grid computing has been the motivating paradigm, StratusLab's cloud distribution can support a wider range of use cases. Towards this direction, we have developed and currently provide support for setting up general purpose computing solutions like Hadoop, MPI and Torque clusters. For what concerns scientific applications the project is collaborating closely with the Bioinformatics community in order to prepare VM appliances and deploy optimized services for bioinformatics applications. In a similar manner additional scientific disciplines like Earth Science can take

  20. Distributing personal resuscitation manikins in an untrained population: how well are basic life support skills acquired?

    DEFF Research Database (Denmark)

    Nielsen, Anne Møller; Isbye, Dan Lou; Rasmussen, Lars Simon;

    2012-01-01

    Background Self-instruction with a DVD and a simple personal manikin is an effective alternative to traditional basic life support (BLS) courses. Objective To evaluate the effect of distributing DVD training kits to untrained laypersons. BLS skills were compared according to 2005 guidelines...... There was no statistically significant difference in the total score after 3.5 months. The 'DVD-self-instructor' group obtained 33 (29-37) points and the 'DVD-with instructor' group obtained 34 (32-37) points, p=0.16. The 'DVD-with instructor' group performed significantly better in checking responsiveness and had...

  1. Local Voltage Support from Distributed Energy Resources to Prevent Air Conditioner Motor Stalling

    Energy Technology Data Exchange (ETDEWEB)

    Baone, Chaitanya A [ORNL; Xu, Yan [ORNL; Kueck, John D [ORNL

    2010-01-01

    Microgrid voltage collapse often happens when there is a high percentage of low inertia air-conditioning (AC) motors in the power systems. The stalling of the AC motors results in Fault Induced Delayed Voltage Recovery (FIDVR). A hybrid load model including typical building loads, AC motor loads, and other induction motor loads is built to simulate the motoring stalling phenomena. Furthermore, distributed energy resources (DE) with local voltage support capability are utilized to boost the local bus voltage during a fault, and prevent the motor stalling. The simulation results are presented. The analysis of the simulation results show that local voltage support from multiple DEs can effectively and economically solve the microgrid voltage collapse problem.

  2. How should financial support for research be distributed to universities? The Research Assessment Exercise (RAE) in England and Wales.

    Science.gov (United States)

    Goldberg, David; Mann, Anthony

    2006-01-01

    In the United Kingdom, the "Research Assessment Exercise" is used by central government as a way of distributing infra-structure funds to University departments to support research. Departments with the highest ratings get extra support, while departments with low ratings may have their existing support withdrawn. The paper describes an exercise aimed at improving the rating obtained by one such department.

  3. Finding Frequent Pattern with Transaction and Occurrences based on Density Minimum Support Distribution

    Directory of Open Access Journals (Sweden)

    Preeti Khare

    2012-09-01

    Full Text Available The importance of data mining is increasing exponentially since last decade and in recent time where there is very tough competition in the market where the quality of information and information on time play a very crucial role in decision making of policy has attracted a great deal of attention in the information industry and in society as a whole. In this approach we also use density minimum support so that we reduce the execution time. A frequent superset means it contains more transactions then the minimum support. It utilize the concept that if the item set is not frequent but the superset may be frequent which is consider for the further data mining task. By this approach we can store the transaction on the daily basis, then we provide three different density zone based on the transaction and minimum support which is low (L, Medium (M, High (H. Based on this approach we categorize the item set for pruning. Our approach is based on apriori algorithm but provides better reduction in time because of the prior separation in the data, which is useful for selecting according to the density wise distribution in India. Our algorithm provides the flexibility for improved association and dynamic support. Comparative result shows the effectiveness of our algorithm.

  4. Evidence for non-random sampling in randomised, controlled trials by Yuhji Saitoh.

    Science.gov (United States)

    Carlisle, J B; Loadsman, J A

    2017-01-01

    A large number of randomised trials authored by Yoshitaka Fujii have been retracted, in part as a consequence of a previous analysis finding a very low probability of random sampling. Dr Yuhji Saitoh co-authored 34 of those trials and he was corresponding author for eight of them. We found a number of additional randomised, controlled trials that included baseline data, with Saitoh as corresponding author, that Fujii did not co-author. We used Monte Carlo simulations to analyse the baseline data from 32 relevant trials in total as well as an outcome (muscle twitch recovery ratios) reported in several. We also compared a series of muscle twitch recovery graphs appearing in a number of Saitoh's publications. The baseline data in 14/32 randomised, controlled trials had p sampling. Combining the continuous and categorical probabilities of the 32 included trials, we found a very low likelihood of random sampling: p = 1.27 × 10(-8) (1 in 100,000,000). The high probability of non-random sampling and the repetition of lines in multiple graphs suggest that further scrutiny of Saitoh's work is warranted. © 2016 The Association of Anaesthetists of Great Britain and Ireland.

  5. A new non-randomized model for analysing sensitive questions with binary outcomes.

    Science.gov (United States)

    Tian, Guo-Liang; Yu, Jun-Wu; Tang, Man-Lai; Geng, Zhi

    2007-10-15

    We propose a new non-randomized model for assessing the association of two sensitive questions with binary outcomes. Under the new model, respondents only need to answer a non-sensitive question instead of the original two sensitive questions. As a result, it can protect a respondent's privacy, avoid the usage of any randomizing device, and be applied to both the face-to-face interview and mail questionnaire. We derive the constrained maximum likelihood estimates of the cell probabilities and the odds ratio for two binary variables associated with the sensitive questions via the EM algorithm. The corresponding standard error estimates are then obtained by bootstrap approach. A likelihood ratio test and a chi-squared test are developed for testing association between the two binary variables. We discuss the loss of information due to the introduction of the non-sensitive question, and the design of the co-operative parameters. Simulations are performed to evaluate the empirical type I error rates and powers for the two tests. In addition, a simulation is conducted to study the relationship between the probability of obtaining valid estimates and the sample size for any given cell probability vector. A real data set from an AIDS study is used to illustrate the proposed methodologies.

  6. Evaluation of stress distribution characteristics on various bar designs of three-implant-supported mandibular overdentures

    Directory of Open Access Journals (Sweden)

    Emre Tokar

    2017-01-01

    Full Text Available Objective: Implant-supported-overdentures, instead of conventional complete dentures, are frequently recommended to rehabilitate patients having edentulous mandible. The aim of this study was to evaluate the stress distribution characteristics of mandibular implant-supported overdentures with four different bar attachment designs. Materials and Method: A photoelastic mandibular model with three implants (3.75 mm - 13 mm placed at the interforaminal region was generated from a cast of an edentulous mandible. Four mandibular bar overdenture designs were fabricated: bar-clip, bar-galvano, bar-locator, and bar-ceka. Axial vertical loads (135 N were applied to the central fossa of the right first molar area for each overdenture design. Stress concentrations were recorded photographically and analyzed visually. Results: The tested bar attachment designs revealed low and moderate stress levels. The lowest stress was observed with the bar-clip design, followed by bar-locator, bar-ceka, and bar-galvano designs. Conclusion: The loads were distributed to all of the implants. Studied designs experienced moderate stress levels around the loaded side implant. Bars with distally placed stud attachments and surface treatment with electroforming seems to increase stress levels around the implants.

  7. Evolving Distributed Generation Support Mechanisms: Case Studies from United States, Germany, United Kingdom, and Australia

    Energy Technology Data Exchange (ETDEWEB)

    Lowder, Travis [National Renewable Energy Lab. (NREL), Golden, CO (United States); Zhou, Ella [National Renewable Energy Lab. (NREL), Golden, CO (United States); Tian, Tian [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2017-03-14

    This report expands on a previous National Renewable Energy Laboratory (NREL) technical report (Lowder et al. 2015) that focused on the United States' unique approach to distributed generation photovoltaics (DGPV) support policies and business models. While the focus of that report was largely historical (i.e., detailing the policies and market developments that led to the growth of DGPV in the United States), this report looks forward, narrating recent changes to laws and regulations as well as the ongoing dialogues over how to incorporate distributed generation (DG) resources onto the electric grid. This report also broadens the scope of Lowder et al. (2015) to include additional countries and technologies. DGPV and storage are the principal technologies under consideration (owing to market readiness and deployment volumes), but the report also contemplates any generation resource that is (1) on the customer side of the meter, (2) used to, at least partly, offset a host's energy consumption, and/or (3) potentially available to provide grid support (e.g., through peak shaving and load shifting, ancillary services, and other means).

  8. A Distributed Architecture for Tsunami Early Warning and Collaborative Decision-support in Crises

    Science.gov (United States)

    Moßgraber, J.; Middleton, S.; Hammitzsch, M.; Poslad, S.

    2012-04-01

    The presentation will describe work on the system architecture that is being developed in the EU FP7 project TRIDEC on "Collaborative, Complex and Critical Decision-Support in Evolving Crises". The challenges for a Tsunami Early Warning System (TEWS) are manifold and the success of a system depends crucially on the system's architecture. A modern warning system following a system-of-systems approach has to integrate various components and sub-systems such as different information sources, services and simulation systems. Furthermore, it has to take into account the distributed and collaborative nature of warning systems. In order to create an architecture that supports the whole spectrum of a modern, distributed and collaborative warning system one must deal with multiple challenges. Obviously, one cannot expect to tackle these challenges adequately with a monolithic system or with a single technology. Therefore, a system architecture providing the blueprints to implement the system-of-systems approach has to combine multiple technologies and architectural styles. At the bottom layer it has to reliably integrate a large set of conventional sensors, such as seismic sensors and sensor networks, buoys and tide gauges, and also innovative and unconventional sensors, such as streams of messages from social media services. At the top layer it has to support collaboration on high-level decision processes and facilitates information sharing between organizations. In between, the system has to process all data and integrate information on a semantic level in a timely manner. This complex communication follows an event-driven mechanism allowing events to be published, detected and consumed by various applications within the architecture. Therefore, at the upper layer the event-driven architecture (EDA) aspects are combined with principles of service-oriented architectures (SOA) using standards for communication and data exchange. The most prominent challenges on this layer

  9. Location-Based Mapping Services to Support Collaboration in Spatially Distributed Workgroups

    Science.gov (United States)

    Meyer, Eike Michael; Wichmann, Daniel; Büsch, Henning; Boll, Susanne

    Mobile devices and systems reached almost every part of our daily life. Following the mobile computing trend, also business logics of distributed, cooperative applications started to move into the mobile client applications. With this shift, the cooperation aspect may also exploit the user’s location and situation context and capabilities of the mobile device and integrate it into the actual cooperation and collaboration. In this paper, we present an approach for a Collaborative Map that exploits the spatial context of the member of a distributed group as a means to visualize and provide collaboration functionality. Then, a number of location-related cooperation methods become feasible such as getting an overview of the spatial distribution of the team members, identify an ad-hoc meeting place nearby, or chat with a group member who has a certain expertise in his or her profile. With CoMa, we move from standard collaboration tools that marginally consider spatial information towards context-aware mobile collaborative systems that can support a wide range of applications such as emergency response, maintenance work or event organization where human resources have to be coordinated in a spatial context and tasks need to be assigned dynamically depending on capabilities and situation context.

  10. Comparison of biofilm ecology supporting growth of individual Naegleria species in a drinking water distribution system.

    Science.gov (United States)

    Puzon, Geoffrey J; Wylie, Jason T; Walsh, Tom; Braun, Kalan; Morgan, Matthew J

    2017-04-01

    Free-living amoebae (FLA) are common components of microbial communities in drinking water distribution systems (DWDS). FLA are of clinical importance both as pathogens and as reservoirs for bacterial pathogens, so identifying the conditions promoting amoebae colonisation of DWDSs is an important public health concern for water utilities. We used high-throughput amplicon sequencing to compare eukaryotic and bacterial communities associated with DWDS biofilms supporting distinct FLA species (Naegleria fowleri, N. lovaniensis or Vermamoeba sp.) at sites with similar physical/chemical conditions. Eukaryote and bacterial communities were characteristics of different FLA species presence, and biofilms supporting Naegleria growth had higher bacterial richness and higher abundance of Proteobacteria, Bacteroidetes (bacteria), Nematoda and Rotifera (eukaryota). The eukaryotic community in the biofilms had the greatest difference in relation to the presence of N. fowleri, while the bacterial community identified individual bacterial families associated with the presence of different Naegleria species. Our results demonstrate that ecogenomics data provide a powerful tool for studying the microbial and meiobiotal content of biofilms, and, in these samples can effectively discriminate biofilm communities supporting pathogenic N. fowleri. The identification of microbial species associated with N. fowleri could further be used in the management and control of N. fowleri in DWDS. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  11. Non-random assembly of bacterioplankton communities in the subtropical North Pacific Ocean

    Directory of Open Access Journals (Sweden)

    Alexander eEiler

    2011-07-01

    Full Text Available The exploration of bacterial diversity in the global ocean has revealed new taxa and previously unrecognized metabolic potential; however, our understanding of what regulates this diversity is limited. Using terminal restriction fragment length polymorphism (T-RFLP data of bacterial small-subunit ribosomal RNA genes we show that, independent of depth and time, a large fraction of bacterioplankton co-occurrence patterns are non-random in the oligotrophic North Pacific subtropical gyre (NPSG. Pair-wise correlations of all identified operational taxonomic units (OTUs revealed a high degree of significance, with 6.6% of the pair-wise co-occurrences being negatively correlated and 20.7% of them being positive. The most abundant OTUs, putatively identified as Prochlorococcus, SAR11 and SAR116 bacteria, were among the most correlated OTUs. As expected, bacterial community composition lacked statistically significant patterns of seasonality in the mostly stratified water column except in a few depth horizons of the sunlit surface waters, with higher frequency variations in community structure apparently related to populations associated with the deep chlorophyll maximum. Communities were structured vertically, with a succession from euphotic, mesopelagic, and bathylopelagic populations. Permutation based statistical analyses of T-RFLP data and their corresponding metadata revealed a broad range of putative environmental drivers controlling bacterioplankton community composition in the NPSG, including concentrations of inorganic nutrients and phytoplankton pigment. Together our results suggest that deterministic forces, such as environmental filtering and interactions among taxa, determine bacterioplankton community patterns, and consequently affect ecosystem functions in the NPSG.

  12. Outcome of Percutaneous Release of Tennis Elbow: A Non-Randomized Controlled Trial Study

    Science.gov (United States)

    Khatri, Kishor; Kharel, Krishna; Byanjankar, Subin; Shrestha, Rahul; Sharma, Jay R; Vaishya, Raju; Agarwal, Amit kumar; Vijay, Vipul

    2017-01-01

    Background Tennis elbow is a common disorder of the upper extremity. It can be treated conservatively in the majority of patients, but some resistant cases eventually can be treated by percutaneous release with good functional outcome. Materials and methods This non-randomized control trial was conducted at the Department of Orthopaedics Surgery in a tertiary care hospital from July 2015 to June 2016 on 50 patients who underwent percutaneous release of the common extensor origin using an 18 gauge hypodermic needle. These patients did not respond to conservative treatment including rest, nonsteroidal anti-inflammatory drugs (NSAIDS) and local steroid injections. The outcome was graded as Excellent, Good, Fair, and Poor. Results Fifty patients (50 elbows) were included in the study. Thirty-two patients were female (64%), and 18 were male (36%). The right side was affected in 37 patients (74%) and left side in 13 (26%). The time taken to achieve a completely pain-free elbow ranged from one day to two months (average of 26.2 days). Those who did not achieve a pain-free elbow had a residual pain of 1.5 to six on the visual analogue scale (VAS) (average 2.32). Excellent outcome was noticed in 24 patients (48%); Good result in eight patients (36% ); Fair in four patients (eight percent) and Poor in four patients (eight percent). Conclusion Tennis elbow probably results from the degenerative tear of the common extensor origin, and a percutaneous tenotomy using an 18 gauge hypodermic needle is a simple, safe, patient-friendly, efficient, and easily reproducible method of treating tennis elbow in those who are resistant to conservative treatment, and it can be done as an outpatient procedure. PMID:28168130

  13. OZONE NUCLEOLYSIS IN LUMBAR INTERVERTEBRAL DISC HERNIATION: NON - RANDOMIZED PROSPECTIVE ANALYSIS

    Directory of Open Access Journals (Sweden)

    Vivekananda S

    2015-05-01

    Full Text Available STUDY DESI GN: Non - randomized, prospective analysis of 68 patients of lumbar disc herniation treated with ozone nucleolysis. OBJECTIVE: To assess the patients with lumbar disc herniation treated with intradiscal ozone, pre and post ozone nucleolysis, for pain using Visual Analog Scale (VAS functional & disability score using Japanese Orthopedic Association (JOA Clinical Symptom Score. SUMMARY OF BACKGROUN D DATA: Ozone therapy for disc herniation is becoming popu lar because of its minimal invasive, lesser recurrences and remarkably fewer side effects. Successful outcomes of ozone therapy have been reported from various European & Indian centers. METHODS: A series of 68 patients were treated with ozone therapy for lumbar disc herniation from January 2009 to January 2012. The procedure is done under C - arm guidance under local anesthesia by “Single sitting double injection technique”. All patients were assessed using VAS for radiation pain & back pain, Clinical Symptom Score of the Japanese Orthopaedic Association (JOA for a Patient with Lumbar Disc Herniation, pre op and post op, on day one, after a week, two weeks, first month, third months, sixth month one year second year. Were classified them as Good, Moder ate & Poor outcome. RESULTS: Out of 68 patients 89.7% (61/68 patients had good outcome, 7.35% (5/68 patients had moderate outcome, 2.95% (2/68 had poor outcome. Intra - op in 1 patient where ozone spread in Para spinal muscles but had no postoperative pro blem.4 patients had mild nausea, 2 had mild headache & No infection. CONCLUSIONS: Ozone nucleolysis is a new, minimally invasive procedure done under local anesthesia & has shown effective results in the treatment of contained intervertebral disc herniatio n with no side effects.

  14. Strategies for improving postpartum contraceptive use: evidence from non-randomized studies.

    Science.gov (United States)

    Lopez, Laureen M; Grey, Thomas W; Chen, Mario; Hiller, Janet E

    2014-11-27

    Nearly two-thirds of women in their first postpartum year have an unmet need for family planning. Adolescents often have repeat pregnancies within a year of giving birth. Women may receive counseling on family planning both antepartum and postpartum. Decisions about contraceptive use made right after counseling may differ considerably from actual postpartum use. In earlier work, we found limited evidence of effectiveness from randomized trials on postpartum contraceptive counseling. For educational interventions, non-randomized studies may be conducted more often than randomized trials. We reviewed non-randomized studies of educational strategies to improve postpartum contraceptive use. Our intent was to examine associations between specific interventions and postpartum contraceptive use or subsequent pregnancy. We searched for eligible non-randomized studies until 3 November 2014. Sources included CENTRAL, PubMed, POPLINE, and Web of Science. We also sought current trials via ClinicalTrials.gov and ICTRP. For additional citations, we examined reference lists of relevant reports and reviews. The studies had to be comparative, i.e., have intervention and comparison groups. The educational component could be counseling or another behavioral strategy to improve contraceptive use among postpartum women. The intervention had to include contact within six weeks postpartum. The comparison condition could be another behavioral strategy to improve contraceptive use, usual care, other health education, or no intervention. Our primary outcomes were postpartum contraceptive use and subsequent pregnancy. Two authors evaluated abstracts for eligibility and extracted data from included studies. We computed the Mantel-Haenszel odds ratio (OR) for dichotomous outcomes and the mean difference (MD) for continuous measures, both with 95% Confidence Intervals (CI). Where studies used adjusted analyses for continuous outcomes, we presented the results as reported by the investigators

  15. Manpower Cost Analysis of a Distributed En Route Support Structure versus a Consolidated En Route Support Structure

    Science.gov (United States)

    2010-03-01

    supporting this type of operation. From a more critical perspective, to reap the benefits of this scenario the necessary aspects of airfield...to Support the Global War on Terrorism, Graduate Research Paper, AFIT/ GMO /ENS/05E-15. School of Engineering and Management, Air Force Institute of

  16. Strategic Simulation - Support of Innovation and Operation in Distribution and production Networks

    DEFF Research Database (Denmark)

    Hansen, Mette Sanne

    Today’s business environment is characterized by global competition, changing conditions, and uncertainty. Many Western companies have responded by developing global distribution and production networks. The increasingly challenging business environment and the more complex structure of companies...... put great emphasis on organisations ability to proactively develop and implement strategies that are dynamic and make it possible for the company to adapt to and plan for the changing circumstances. Many approaches to strategy development exist, but most of them are based on either qualitative...... or quantitative approaches. Strategic simulation is the combination of narrative and numerical simulation and can be used as a tool to support strategic decision making by providing different scenarios in combination with computer modelling. The core of the combined simulation approach (CSA) is to make...

  17. SiC heat pump converters with support for voltage unbalance in distribution grids

    DEFF Research Database (Denmark)

    Trintis, Ionut; Douglass, Philip; Maheshwari, Ramkrishan

    2015-01-01

    This paper studies the impact of involving the demand side of the LV grid into the grid conditioning process. Heat pumps are distribution loads with a substation capacity increase in the last years, with expectancy of growth in the coming years. Controlling the loads is the first step...... in the transition to smart grids, and heat pumps are to be the first promising smart loads. They can be used for load shedding but also for unbalance compensation purposes. When they are equipped with a back to back compressor drive and a proper control strategy, grid support can be provided to reduce the negative...... sequence component in the voltage at the installation point. Two control strategies are proposed and investigated experimentally on a SiC heat pump converter prototype....

  18. A spatial model for sporadic tree species distribution in support of tree oriented silviculture

    Directory of Open Access Journals (Sweden)

    Davide Melini

    2013-12-01

    Full Text Available This technical note describes how a spatial model for sporadic tree species distribution in the territory of the Unione di Comuni Montana Colline Metallifere (UCMCM was built using the Random Forest (RF algorithm and 48 predictors, including reflectance values from ground cover - provided by satellite sensors - and ecological factors. The  P.Pro.SPO.T. project - Policy and Protection of Sporadic tree species in Tuscany forest (LIFE 09 ENV/IT/000087 is currently carried out in this area with the purpose of initiating the implementation of tree oriented silviculture in the Tuscany forests. Tree oriented silviculture aims at obtaining both forest biodiversity protection and local production of valuable timber. After creating a map showing the probability of presence of sporadic tree species, it was possible to identify the most suitable areas for sporadic tree species which are under protection according to the regulation of the Tuscany Region.Using data and software provided free of charge, and applying the RF algorithm, distribution models could be developed in order to identify the most suitable areas for the application of tree oriented silviculture. This can provide a support to forestry planning that includes tree oriented silviculture, thus reducing its implementation cost.

  19. Stress distribution in implant-supported prostheses using different connection systems and cantilever lengths: digital photoelasticity.

    Science.gov (United States)

    Goiato, Marcelo Coelho; Shibayama, Ricardo; Gennari Filho, Humberto; de Medeiros, Rodrigo Antonio; Pesqueira, Aldiéris Alves; dos Santos, Daniela Micheline; de Araújo, Cleudmar Amaral

    2016-01-01

    Photoelastic analysis was used to evaluate the biomechanical behaviour of implant-supported, double-screwed crowns with different connection systems and cantilever lengths. Three models were made in PL-2 photoelastic resin and divided into six groups, on the basis of the implant connection system (external hexagon [EH] or Morse taper [MT]), type of abutment (Mini Pilar [Neodent, Curitiba, Paraná, Brazil] or "UCLA") and number of crowns in the cantilever (one or two). The implant-prosthesis unit was placed in a circular polariscope. Occlusal surfaces of the crowns were subjected to 100-N loads in the axial and oblique (45°) directions in a universal testing machine (EMIC). Generated stresses were recorded and analysed qualitatively in a graphics program (Adobe Photoshop). Under axial loading, all of the groups had similar numbers of fringes, which were increased when the crowns were subjected to oblique loading. The highest number of fringes was found during oblique loading in the EH + Mini Pilar group. In conclusion, although the type of implant connection system did not have a direct influence on the stress distribution for axial loading, the cantilever length did have a direct influence on stress distribution. Models with two crowns in the cantilever showed more stress, with a greater concentration of force on the cervical part of the implant.

  20. Supporting the Loewenstein occupational therapy cognitive assessment using distributed user interfaces.

    Science.gov (United States)

    Tesoriero, Ricardo; Gallud Lazaro, Jose A; Altalhi, Abdulrahman H

    2017-02-01

    Improve the quantity and quality of information obtained from traditional Loewenstein Occupational Therapy Cognitive Assessment Battery systems to monitor the evolution of patients' rehabilitation process as well as to compare different rehabilitation therapies. The system replaces traditional artefacts with virtual versions of them to take advantage of cutting edge interaction technology. The system is defined as a Distributed User Interface (DUI) supported by a display ecosystem, including mobile devices as well as multi-touch surfaces. Due to the heterogeneity of the devices involved in the system, the software technology is based on a client-server architecture using the Web as the software platform. The system provides therapists with information that is not available (or it is very difficult to gather) using traditional technologies (i.e. response time measurements, object tracking, information storage and retrieval facilities, etc.). The use of DUIs allows therapists to gather information that is unavailable using traditional assessment methods as well as adapt the system to patients' profile to increase the range of patients that are able to take this assessment. Implications for Rehabilitation Using a Distributed User Interface environment to carry out LOTCAs improves the quality of the information gathered during the rehabilitation assessment. This system captures physical data regarding patient's interaction during the assessment to improve the rehabilitation process analysis. Allows professionals to adapt the assessment procedure to create different versions according to patients' profile. Improves the availability of patients' profile information to therapists to adapt the assessment procedure.

  1. A distributed computing environment with support for constraint-based task scheduling and scientific experimentation

    Energy Technology Data Exchange (ETDEWEB)

    Ahrens, J.P.; Shapiro, L.G.; Tanimoto, S.L. [Univ. of Washington, Seattle, WA (United States). Dept. of Computer Science and Engineering

    1997-04-01

    This paper describes a computing environment which supports computer-based scientific research work. Key features include support for automatic distributed scheduling and execution and computer-based scientific experimentation. A new flexible and extensible scheduling technique that is responsive to a user`s scheduling constraints, such as the ordering of program results and the specification of task assignments and processor utilization levels, is presented. An easy-to-use constraint language for specifying scheduling constraints, based on the relational database query language SQL, is described along with a search-based algorithm for fulfilling these constraints. A set of performance studies show that the environment can schedule and execute program graphs on a network of workstations as the user requests. A method for automatically generating computer-based scientific experiments is described. Experiments provide a concise method of specifying a large collection of parameterized program executions. The environment achieved significant speedups when executing experiments; for a large collection of scientific experiments an average speedup of 3.4 on an average of 5.5 scheduled processors was obtained.

  2. Cortical atrophy patterns in multiple sclerosis are non-random and clinically relevant.

    Science.gov (United States)

    Steenwijk, Martijn D; Geurts, Jeroen J G; Daams, Marita; Tijms, Betty M; Wink, Alle Meije; Balk, Lisanne J; Tewarie, Prejaas K; Uitdehaag, Bernard M J; Barkhof, Frederik; Vrenken, Hugo; Pouwels, Petra J W

    2016-01-01

    cortical atrophy in multiple sclerosis occurs largely in a non-random manner and develops (at least partly) according to distinct anatomical patterns. In addition, these cortical atrophy patterns showed stronger associations with clinical (especially cognitive) dysfunction than global cortical atrophy.

  3. Multidisciplinary intervention reducing readmissions in medical inpatients: a prospective, non-randomized study

    Directory of Open Access Journals (Sweden)

    Torisson G

    2013-09-01

    Full Text Available Gustav Torisson,1 Lennart Minthon,1 Lars Stavenow,2 Elisabet Londos1 1Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, 2Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden Background: The purpose of this study was to examine whether a multidisciplinary intervention targeting drug-related problems, cognitive impairment, and discharge miscommunication could reduce readmissions in a general hospital population. Methods: This prospective, non-randomized intervention study was carried out at the department of general internal medicine at a tertiary university hospital. Two hundred medical inpatients living in the community and aged over 60 years were included. Ninety-nine patients received interventions and 101 received standard care. Control/intervention allocation was determined by geographic selection. Interventions consisted of a comprehensive medication review, improved discharge planning, post-discharge telephone follow-up, and liaison with the patient's general practitioner. The main outcome measures recorded were readmissions and hospital nights 12 months after discharge. Separate analyses were made for 12-month survivors and from an intention-to-treat perspective. Comparative analyses were made between groups as well as within groups over time. Results: After 12 months, survivors in the control group had 125 readmissions in total, compared with 58 in the intervention group (Mann–Whitney U test, P = 0.02. For hospital nights, the numbers were 1,228 and 492, respectively (P = 0.009. Yearly admissions had increased from the previous year in the control group from 77 to 125 (Wilcoxon signed-rank test, P = 0.002 and decreased from 75 to 58 in the intervention group (P = 0.25. From the intention-to-treat perspective, the same general pattern was observed but was not significant (1,827 versus 1,008 hospital nights, Mann–Whitney test, P = 0.054. Conclusion: A multidisciplinary approach

  4. [Influence of attachment type on stress distribution of implant-supported removable partial dentures].

    Science.gov (United States)

    Yang, Xue; Rong, Qi-guo; Yang, Ya-dong

    2015-02-18

    To compare influences of different retention attachments on stress among supporting structures. By 3-dimensional laser scanner and reverse engineering computer aided design (CAD) software, a basic partially edentulous digital model with mandibular premolar and molar missing was established. Implant attachment and removable partial dentures (RPD) were added into the basic model to build three kinds of models: RPD only, RPD + implant + Locator attachment, and RPD + implant + Magfit attachment. Vertical and inclined loads were put on artificial teeth unilaterally. By means of 3-dimensional finite element analysis, the stress distribution and displacement of the main supportive structures were compared. A complete 3-dimensional finite element model was established, which contained tooth structure, and periodontal structures. The displacement of the denture was smaller in Locator (9.38 μm vertically, 45.48 μm obliquely) and Magfit models (9.54 μm vertically, 39.45 μm obliquely) compared with non-implant RPD model (95.27 μm vertically, 155.70 μm obliquely). Compared with the two different attachments, cortical bone stress value was higher in Locator model (Locator model 10.850 MPa vertically, 43.760 MPa obliquely; Magfit model 7.100 MPa vertically, 19.260 MPa obliquely).The stress value of abutment periodontal ligamentin Magfit model (0.420 MPa vertically) was lower than that in Locator model (0.520 MPa vertically). The existence of implant could reduce maximum von Mises value of each supportive structure when Kennedy I partially edentulous mandible was restored. Comparing the structure of Magfit and Locator attachment, the contact of Magfit attachment was rigid, while Locator was resilient. Locator attachment could improve stability of the denture dramatically. Locator had stronger effect on defending horizontal movement of the denture.

  5. The Association between Perceptions of Distributive Justice and Procedural Justice with Support of Treatment and Support of Punishment among Correctional Staff

    Science.gov (United States)

    Lambert, Eric G.; Hogan, Nancy L.; Barton-Bellessa, Shannon M.

    2011-01-01

    Previous literature exploring the relationship between correctional officer orientations toward treatment and punishment is inconsistent at best. One rarely studied aspect is the influence of distributive and procedural justice on correctional staff support for treatment and punishment. For this study, ordinary least squares regression analysis of…

  6. The Association between Perceptions of Distributive Justice and Procedural Justice with Support of Treatment and Support of Punishment among Correctional Staff

    Science.gov (United States)

    Lambert, Eric G.; Hogan, Nancy L.; Barton-Bellessa, Shannon M.

    2011-01-01

    Previous literature exploring the relationship between correctional officer orientations toward treatment and punishment is inconsistent at best. One rarely studied aspect is the influence of distributive and procedural justice on correctional staff support for treatment and punishment. For this study, ordinary least squares regression analysis of…

  7. A Distributed Control System Prototyping Environment to Support Control Room Modernization

    Energy Technology Data Exchange (ETDEWEB)

    Lew, Roger Thomas [Idaho National Lab. (INL), Idaho Falls, ID (United States); Boring, Ronald Laurids [Idaho National Lab. (INL), Idaho Falls, ID (United States); Ulrich, Thomas Anthony [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-12-01

    Operators of critical processes, such as nuclear power production, must contend with highly complex systems, procedures, and regulations. Developing human-machine interfaces (HMIs) that better support operators is a high priority for ensuring the safe and reliable operation of critical processes. Human factors engineering (HFE) provides a rich and mature set of tools for evaluating the performance of HMIs, however the set of tools for developing and designing HMIs is still in its infancy. Here we propose a rapid prototyping approach for integrating proposed HMIs into their native environments before a design is finalized. This approach allows researchers and developers to test design ideas and eliminate design flaws prior to fully developing the new system. We illustrate this approach with four prototype designs developed using Microsoft’s Windows Presentation Foundation (WPF). One example is integrated into a microworld environment to test the functionality of the design and identify the optimal level of automation for a new system in a nuclear power plant. The other three examples are integrated into a full-scale, glasstop digital simulator of a nuclear power plant. One example demonstrates the capabilities of next generation control concepts; another aims to expand the current state of the art; lastly, an HMI prototype was developed as a test platform for a new control system currently in development at U.S. nuclear power plants. WPF possesses several characteristics that make it well suited to HMI design. It provides a tremendous amount of flexibility, agility, robustness, and extensibility. Distributed control system (DCS) specific environments tend to focus on the safety and reliability requirements for real-world interfaces and consequently have less emphasis on providing functionality to support novel interaction paradigms. Because of WPF’s large user-base, Microsoft can provide an extremely mature tool. Within process control applications,WPF is

  8. HADOOP-BASED DISTRIBUTED SYSTEM FOR ONLINE PREDICTION OF AIR POLLUTION BASED ON SUPPORT VECTOR MACHINE

    Directory of Open Access Journals (Sweden)

    Z. Ghaemi

    2015-12-01

    Full Text Available The critical impact of air pollution on human health and environment in one hand and the complexity of pollutant concentration behavior in the other hand lead the scientists to look for advance techniques for monitoring and predicting the urban air quality. Additionally, recent developments in data measurement techniques have led to collection of various types of data about air quality. Such data is extremely voluminous and to be useful it must be processed at high velocity. Due to the complexity of big data analysis especially for dynamic applications, online forecasting of pollutant concentration trends within a reasonable processing time is still an open problem. The purpose of this paper is to present an online forecasting approach based on Support Vector Machine (SVM to predict the air quality one day in advance. In order to overcome the computational requirements for large-scale data analysis, distributed computing based on the Hadoop platform has been employed to leverage the processing power of multiple processing units. The MapReduce programming model is adopted for massive parallel processing in this study. Based on the online algorithm and Hadoop framework, an online forecasting system is designed to predict the air pollution of Tehran for the next 24 hours. The results have been assessed on the basis of Processing Time and Efficiency. Quite accurate predictions of air pollutant indicator levels within an acceptable processing time prove that the presented approach is very suitable to tackle large scale air pollution prediction problems.

  9. Hadoop-Based Distributed System for Online Prediction of Air Pollution Based on Support Vector Machine

    Science.gov (United States)

    Ghaemi, Z.; Farnaghi, M.; Alimohammadi, A.

    2015-12-01

    The critical impact of air pollution on human health and environment in one hand and the complexity of pollutant concentration behavior in the other hand lead the scientists to look for advance techniques for monitoring and predicting the urban air quality. Additionally, recent developments in data measurement techniques have led to collection of various types of data about air quality. Such data is extremely voluminous and to be useful it must be processed at high velocity. Due to the complexity of big data analysis especially for dynamic applications, online forecasting of pollutant concentration trends within a reasonable processing time is still an open problem. The purpose of this paper is to present an online forecasting approach based on Support Vector Machine (SVM) to predict the air quality one day in advance. In order to overcome the computational requirements for large-scale data analysis, distributed computing based on the Hadoop platform has been employed to leverage the processing power of multiple processing units. The MapReduce programming model is adopted for massive parallel processing in this study. Based on the online algorithm and Hadoop framework, an online forecasting system is designed to predict the air pollution of Tehran for the next 24 hours. The results have been assessed on the basis of Processing Time and Efficiency. Quite accurate predictions of air pollutant indicator levels within an acceptable processing time prove that the presented approach is very suitable to tackle large scale air pollution prediction problems.

  10. Comparative stress distribution of implant-retained mandibular ball-supported and bar-supported overlay dentures: a finite element analysis.

    Science.gov (United States)

    Vafaei, Fariborz; Khoshhal, Masoumeh; Bayat-Movahed, Saeed; Ahangary, Ahmad Hassan; Firooz, Farnaz; Izady, Alireza; Rakhshan, Vahid

    2011-08-01

    Implant-retained mandibular ball-supported and bar-supported overlay dentures are the two most common treatment options for the edentulous mandible. The superior option in terms of strain distribution should be determined. The three-dimensional model of mandible (based on computerized tomography scan) and its overlying implant-retained bar-supported and ball-supported overlay dentures were simulated using SolidWorks, NURBS, and ANSYS Workbench. Loads A (60 N) and B (60 N) were exerted, respectively, in protrusive and laterotrusive motions, on second molar mesial, first molar mesial, and first premolar. The strain distribution patterns were assessed on (1) implant tissue, (2) first implant-bone, and (3) second implant-bone interfaces. Protrusive: Strain was mostly detected in the apical of the fixtures and least in the cervical when bar design was used. On the nonworking side, however, strain was higher in the cervical and lower in the apical compared with the working side implant. Laterotrusive: The strain values were closely similar in the two designs. It seems that both designs are acceptable in terms of stress distribution, although a superior pattern is associated with the application of bar design in protrusive motion.

  11. The nuclear position of pericentromeric DNA of chromosome 11 appears to be random in G0 and non-random in G1 human lymphocytes.

    Science.gov (United States)

    Hulspas, R; Houtsmuller, A B; Krijtenburg, P J; Bauman, J G; Nanninga, N

    1994-07-01

    The nuclear topography of pericentromeric DNA of chromosome 11 was analyzed in G0 (nonstimulated) and G1 [phytohemagglutinin (PHA) stimulated] human lymphocytes by confocal microscopy. In addition to the nuclear center, the centrosome was used as a second point of reference in the three-dimensional (3D) analysis. Pericentromeric DNA of chromosome 11 and the centrosome were labeled using a combination of fluorescent in situ hybridization (FISH) and immunofluorescence. To preserve the 3D morphology of the cells, these techniques were performed on whole cells in suspension. Three-dimensional images of the cells were analyzed with a recently developed 3D software program (Interactive Measurement of Axes and Positioning in 3 Dimensions). The distribution of the chromosome 11 centromeres appeared to be random during the G0 stage but clearly non-random during the G1 stage, when the nuclear center was used as a reference point. Further statistical analysis of the G1 cells revealed that the centromeres were randomly distributed in a shell underlying the nuclear membrane. A topographical relationship between the centrosome and the centromeres appeared to be absent during the G0 and G1 stages of the cell cycle.

  12. CO2 Data Distribution and Support from the Goddard Earth Science Data and Information Services Center (GES-DISC)

    Science.gov (United States)

    Hearty, Thomas; Savtchenko, Andrey; Vollmer, Bruce; Albayrak, Arif; Theobald, Mike; Esfandiari, Ed; Wei, Jennifer

    2015-01-01

    This talk will describe the support and distribution of CO2 data products from OCO-2, AIRS, and ACOS, that are archived and distributed from the Goddard Earth Sciences Data and Information Services Center. We will provide a brief summary of the current online archive and distribution metrics for the OCO-2 Level 1 products and plans for the Level 2 products. We will also describe collaborative data sets and services (e.g., matchups with other sensors) and solicit feedback for potential future services.

  13. Decision Support for DCs Location and Distribute Range Planning:Case Study in Asia-Pacific Region

    Institute of Scientific and Technical Information of China (English)

    WATTANAAMAT Patikorn; MATSUMARU Masanobu; YAMASHITA Hiroshi

    2004-01-01

    A major concern is to locate manufacturing plants and/or distribution centers to serve the needs of consumers widely and rapidly with reasonably distributive cost and flexible delivery time.The purpose of this research is to help enhance a decision support for three distribution center locations with different ranges of area in order that the distributors are able to serve appropriately the retailers in twelve large cities or capitals of the nine countries in Asia-Pacific region.The researcher applies the theory of supply chain and logistics management systems with Excel,Visual Basic and Genetic Algorithms programs to find the research results. The research results revealed that the interfaces of Excel, Visual Basic, and Genetic Algorithms programs helped decision support in distribution range selection for 3 distribution center locations. Each of which had different ranges of area for distribution with a rapidly, flexibly distributed time. However, variables resulting in a decision-making should be adjusted under certain circumstances for more reliable, specific needs.

  14. Bias analysis applied to Agricultural Health Study publications to estimate non-random sources of uncertainty

    Directory of Open Access Journals (Sweden)

    Lash Timothy L

    2007-11-01

    Full Text Available Abstract Background The associations of pesticide exposure with disease outcomes are estimated without the benefit of a randomized design. For this reason and others, these studies are susceptible to systematic errors. I analyzed studies of the associations between alachlor and glyphosate exposure and cancer incidence, both derived from the Agricultural Health Study cohort, to quantify the bias and uncertainty potentially attributable to systematic error. Methods For each study, I identified the prominent result and important sources of systematic error that might affect it. I assigned probability distributions to the bias parameters that allow quantification of the bias, drew a value at random from each assigned distribution, and calculated the estimate of effect adjusted for the biases. By repeating the draw and adjustment process over multiple iterations, I generated a frequency distribution of adjusted results, from which I obtained a point estimate and simulation interval. These methods were applied without access to the primary record-level dataset. Results The conventional estimates of effect associating alachlor and glyphosate exposure with cancer incidence were likely biased away from the null and understated the uncertainty by quantifying only random error. For example, the conventional p-value for a test of trend in the alachlor study equaled 0.02, whereas fewer than 20% of the bias analysis iterations yielded a p-value of 0.02 or lower. Similarly, the conventional fully-adjusted result associating glyphosate exposure with multiple myleoma equaled 2.6 with 95% confidence interval of 0.7 to 9.4. The frequency distribution generated by the bias analysis yielded a median hazard ratio equal to 1.5 with 95% simulation interval of 0.4 to 8.9, which was 66% wider than the conventional interval. Conclusion Bias analysis provides a more complete picture of true uncertainty than conventional frequentist statistical analysis accompanied by a

  15. Applying SDN/OpenFlow in Virtualized LTE to support Distributed Mobility Management (DMM)

    NARCIS (Netherlands)

    Karimzadeh, Morteza; Valtulina, Luca; Karagiannis, Georgios

    2014-01-01

    Distributed Mobility Management (DMM) is a mobility management solution, where the mobility anchors are distributed instead of being centralized. The use of DMM can be applied in cloud-based (virtualized) Long Term Evolution (LTE) mobile network environments to (1) provide session continuity to user

  16. A Stochastic After-Taxes Optimisation Model to Support Distribution Network Strategies

    DEFF Research Database (Denmark)

    Fernandes, Rui; Hvolby, Hans-Henrik; Gouveia, Borges

    2012-01-01

    The paper proposes a stochastic model to integrate tax issues into strategic distribution network decisions. Specifically, this study will explore the role of distribution models in business profitability, and how to use the network design to deliver additional bottom-line results, using...

  17. Assessing cognitive load distributions for envisioned task allocations and support functions

    NARCIS (Netherlands)

    Neerincx, M.A.; Dobbelsteen, G.J.H. van den; Grootjen, M.; Veenendaal, J. van

    2003-01-01

    Information technology provides new possibilities to combine and support operator tasks in order to improve the operational effectiveness and efficiency on board of a ship. The general question is how to design a task allocation and support system that lead to an adequate deployment of the human cog

  18. A Stochastic After-Taxes Optimisation Model to Support Distribution Network Strategies

    DEFF Research Database (Denmark)

    Fernandes, Rui; Hvolby, Hans-Henrik; Gouveia, Borges

    2012-01-01

    The paper proposes a stochastic model to integrate tax issues into strategic distribution network decisions. Specifically, this study will explore the role of distribution models in business profitability, and how to use the network design to deliver additional bottom-line results, using...... distribution centres located in different countries. The challenge is also to reveal how financial and tax knowledge can help logistic leaders improving the value to their companies under global solutions and sources of business net profitability in a dynamic environment. In particular, based on inventory...

  19. Execution time supports for adaptive scientific algorithms on distributed memory machines

    Science.gov (United States)

    Berryman, Harry; Saltz, Joel; Scroggs, Jeffrey

    1990-01-01

    Optimizations are considered that are required for efficient execution of code segments that consists of loops over distributed data structures. The PARTI (Parallel Automated Runtime Toolkit at ICASE) execution time primitives are designed to carry out these optimizations and can be used to implement a wide range of scientific algorithms on distributed memory machines. These primitives allow the user to control array mappings in a way that gives an appearance of shared memory. Computations can be based on a global index set. Primitives are used to carry out gather and scatter operations on distributed arrays. Communications patterns are derived at runtime, and the appropriate send and receive messages are automatically generated.

  20. Cognition in context : the effect of information and communication support on task performance of distributed professionals

    NARCIS (Netherlands)

    Biemans, Margaretha Catharina Maria

    2006-01-01

    Mobile collaboration is emerging. Developments in technological and business areas provide opportunities for innovative applications and new ways of working. Mobile applications have possibilities to provide context information and to enrich the communication between distributed professionals. Such

  1. The support of the limit distribution of optimal Riesz energy points on sets of revolution in $\\mathbb{R}^{3}$

    CERN Document Server

    Brauchart, J S; Saff, E B

    2007-01-01

    Let A be a compact set in the right-half plane and $\\Gamma(A)$ the set in $\\mathbb{R}^{3}$ obtained by rotating A about the vertical axis. We investigate the support of the limit distribution of minimal energy point charges on $\\Gamma(A)$ that interact according to the Riesz potential 1/r^{s}, 0distribution coincides with the equilibrium measure on $\\Gamma(A)$ which is supported on the outer boundary of $\\Gamma(A)$. We show that there are sets of revolution $\\Gamma(A)$ such that the support of the equilibrium measure on $\\Gamma(A)$ is {\\bf not} the complete outer boundary, in contrast to the Coulomb case s=1. However, the support of the limit distribution on the set of revolution $\\Gamma(R+A)$ as R goes to infinity, is the full outer boundary for certain sets A, in contrast to the logarithmic case (s=0).

  2. Network Regulation and Support Schemes - How Policy Interactions Affect the Integration of Distributed Generation

    DEFF Research Database (Denmark)

    Ropenus, Stephanie; Jacobsen, Henrik; Schröder, Sascha Thorsten

    2011-01-01

    -off between the incentives for these two market agents to facilitate the integration of distributed generation. Secondly, the interaction of these policy dimensions is analyzed, including case studies based on five EU Member States. Aspects of operational nature and investments in grid and distributed...... generation facilities are covered. The question in which policy segment to incorporate locational signals is at the heart of the debate...

  3. How Social Software Supports Cooperative Practices in a Globally Distributed Software Project

    DEFF Research Database (Denmark)

    Giuffrida, Rosalba; Dittrich, Yvonne

    2014-01-01

    In Global Software Development (GSD), the lack of face- to-face communication is a major challenge and effective computer-mediated practices are necessary. This paper analyzes cooperative practices supported by Social Software (SoSo) in a GSD student project. The empirical results show...... that the role of SoSo is to support informal communication, enabling social talks and metawork, both necessary for establishing and for maintaining effective coordination mechanisms, thus successful cooperation....

  4. A DiffServ Supporting And Distributed Dynamic Dual Round Robin Scheduling Algorithm on DS-CICQ

    Science.gov (United States)

    Xiuqin, Li; Luoheng, Yan; Julong, Lan

    A distributed dynamic dual round robin scheduling algorithm (DSDRR) that can support differential services is presented. For each scheduler, the strategy of double pointer and round robin is adopted and scheduling complexity is substantially reduced. Its quantum function, related to the status of input queue and priority, is a traffic-adaptive dynamic scheduling mechanism and is rather sensitive to the changing network; therefore, it has the traits of dynamics and fairness. It can better support differential services and guarantee the realization of QoS.

  5. Non-random retention of protein-coding overlapping genes in Metazoa

    Directory of Open Access Journals (Sweden)

    Bork Peer

    2008-04-01

    Full Text Available Abstract Background Although the overlap of transcriptional units occurs frequently in eukaryotic genomes, its evolutionary and biological significance remains largely unclear. Here we report a comparative analysis of overlaps between genes coding for well-annotated proteins in five metazoan genomes (human, mouse, zebrafish, fruit fly and worm. Results For all analyzed species the observed number of overlapping genes is always lower than expected assuming functional neutrality, suggesting that gene overlap is negatively selected. The comparison to the random distribution also shows that retained overlaps do not exhibit random features: antiparallel overlaps are significantly enriched, while overlaps lying on the same strand and those involving coding sequences are highly underrepresented. We confirm that overlap is mostly species-specific and provide evidence that it frequently originates through the acquisition of terminal, non-coding exons. Finally, we show that overlapping genes tend to be significantly co-expressed in a breast cancer cDNA library obtained by 454 deep sequencing, and that different overlap types display different patterns of reciprocal expression. Conclusion Our data suggest that overlap between protein-coding genes is selected against in Metazoa. However, when retained it may be used as a species-specific mechanism for the reciprocal regulation of neighboring genes. The tendency of overlaps to involve non-coding regions of the genes leads to the speculation that the advantages achieved by an overlapping arrangement may be optimized by evolving regulatory non-coding transcripts.

  6. An information flow analysis of a distributed information system for space medical support.

    Science.gov (United States)

    Zhang, Tao; Aranzamendez, Gina; Rinkus, Susan; Gong, Yang; Rukab, Jamie; Johnson-Throop, Kathy A; Malin, JaneT; Zhang, Jiajie

    2004-01-01

    In this study, we applied the methodology grounded in human-centered distributed cognition principles to the information flow analysis of a highly intensive, distributed and complex environment--the Biomedical Engineer (BME) console system at NASA Johnson Space Center. This system contains disparate human and artificial agents and artifacts. Users and tasks of this system were analyzed. An ethnographic study and a detailed communication pattern analysis were conducted to gain deeper insight and better understanding of the information flow patterns and the organizational memory of the current BME console system. From this study, we identified some major problems and offered recommendations to improve the efficiency and effectiveness of this system. We believe that this analysis methodology can be used in other distributed information systems, such as a healthcare environment.

  7. Sphere quadtrees - A new data structure to support the visualization of spherically distributed data

    Science.gov (United States)

    Fekete, Gyorgy; Treinish, Lloyd

    1990-01-01

    The concept of the sphere quadtree (SQT) is introduced to enable the structuring of spherically distributed data to be consistent with its geometry and facilitate mapping of the data onto a flat file system. The SQT is based on the recursive subdivision of the spherical triangles that result from the projection of the faces of an icosahedron onto a sphere. The SQT concept is insensitive to the distortions that occur far from the equator in spherically distributed data sets. Geographic data can be shown at several levels and at any resolution, allowing a system of referencing between data sets of different resolutions as well as data that are not geographically registered. SQTs are found to facilitate the search for particular spherically distributed data sets and improve the efficiency of surface rendering algorithms.

  8. Conservation principles suspended solids distribution modeling to support ATS introduction on a recirculating WWTP

    DEFF Research Database (Denmark)

    Gernaey, Krist Victor Bernard; Nielsen, M.K.; Thornberg, D.

    2004-01-01

    A model for the description of the SS distribution in a full-scale recirculating activated sludge WWTP was developed. The model, based on conservation principles, uses on-line plant data as model inputs, and provides a prediction of the SS load in the inlet to the secondary clarifiers and the SS...... distribution in the WWTP as outputs. The calibrated model produces excellent predictions of the SS load to the secondary clarifiers, an essential variable for the operation of the aeration tank settling (ATS) process. A case study illustrated how the calibrated SS distribution model can be used to evaluate...... the potential benefit of ATS implementation on a full-scale recirculating WWTP. A reduction of the maximum SS peak load to the secondary clarifiers with 24.9% was obtained with ATS, whereas the cumulative SS load to the clarifiers is foreseen to be reduced with 22.5% for short rain events (4 hours duration...

  9. Intervention for homeless, substance abusing mothers: findings from a non-randomized pilot.

    Science.gov (United States)

    Slesnick, Natasha; Erdem, Gizem

    2012-01-01

    Little empirically-based information is available regarding how best to intervene with substance-abusing homeless mothers. This study pilot-tested a comprehensive intervention with 15 homeless women and their 2- to 6-year-old children, recruited from a local family shelter. All participants were offered integrated intervention with three major components. The first component was housing which included 3 months of rental and utility assistance, and these services were not contingent upon women's abstinence from drugs or alcohol. The second and third components included 6 months of case management services and an evidence-based substance abuse treatment (Community Reinforcement Approach; CRA). Analysis revealed that women showed reductions in substance use (F(2,22) = 3.63; p homelessness (F(2,24) = 25.31; p intervention is a promising approach to meet the multiple needs of this vulnerable population. These positive outcomes support the need for future research to replicate the findings with a larger sample using a randomized design.

  10. Analysis of load distribution in tooth-implant supported fixed partial dentures by the use of resilient abutment

    OpenAIRE

    Glišić Mirko; Stamenković Dragoslav; Grbović Aleksandar; Todorović Aleksandar; Marković Aleksa; Trifković Branka

    2016-01-01

    Introduction. Differences between the tooth and implant response to load can lead to many biological and technical implications in the conditions of occlusal forces. Objective. The objective of this study was to analyze load distribution in tooth/implant-supported fixed partial dentures with the use of resilient TSA (Titan Shock Absorber, BoneCare GmbH, Augsburg, Germany) abutment and conventional non-resilient abutment using finite element method. Methods....

  11. A computer-based decision support system aids distribution in planning and control of foodservices.

    Science.gov (United States)

    Hicks, Z R; Matthews, M E; Norback, J P

    1986-09-01

    Three scenarios, developed from typical situations in the foodservice, were stimulated on the Sperry 1100/80 computer to illustrate how the decision support system assisted dietitians. The scenarios included an analysis of price changes and discounts from a potential vendor; menu planning and pricing for a holiday dinner for 800 to 900 employees; and a comparison of costs between 1 day of meals for a patient on a general and a diabetic diet. In the analysis of price discounts, 1.5 hours were required for finding an acceptable solution using the decision support system. Prices were changed on 349 ingredients; then matrix multiplication within the decision support system resulted in recosting all menu items with those ingredients and provided new prices for cost per meals. Eight new ingredients, 13 menu items, and 2 menu plans for two different holiday meals were entered into the computer; precise amounts and prices for menu items and meals were obtained in 1 hour. Twelve hours was the minimum time estimated for finding a solution by hand calculations. Time to calculate costs of 27 different menu items for one patient day was estimated to be 9 hours manually. With the decision support system, cost comparisons were available in 1 hour. Both the usefulness and the potential of the decision support system were demonstrated.

  12. Non-random co-occurrence of native and exotic plant species in Mediterranean grasslands

    Science.gov (United States)

    de Miguel, José M.; Martín-Forés, Irene; Acosta-Gallo, Belén; del Pozo, Alejandro; Ovalle, Carlos; Sánchez-Jardón, Laura; Castro, Isabel; Casado, Miguel A.

    2016-11-01

    Invasion by exotic species in Mediterranean grasslands has determined assembly patterns of native and introduced species, knowledge of which provides information on the ecological processes underlying these novel communities. We considered grasslands from Spain and Chile. For each country we considered the whole grassland community and we split species into two subsets: in Chile, species were classified as natives or colonizers (i.e. exotics); in Spain, species were classified as exclusives (present in Spain but not in Chile) or colonizers (Spanish natives and exotics into Chile). We used null models and co-occurrence indices calculated in each country for each one of 15 sites distributed along a precipitation gradient and subjected to similar silvopastoral exploitation. We compared values of species co-occurrence between countries and between species subsets (natives/colonizers in Chile; exclusives/colonizers in Spain) within each country and we characterised them according to climatic variables. We hypothesized that: a) the different coexistence time of the species in both regions should give rise to communities presenting a spatial pattern further from random in Spain than in Chile, b) the co-occurrence patterns in the grasslands are affected by mesoclimatic factors in both regions. The patterns of co-occurrence are similar in Spain and Chile, mostly showing a spatial pattern more segregated than expected by random. The colonizer species are more segregated in Spain than in Chile, possibly determined by the longer residence time of the species in the source area than in the invaded one. The segregation of species in Chile is related to water availability, being species less segregated in habitat with greater water deficit; in Spain no relationship with climatic variables was found. After an invasion process, our results suggest that the possible process of alteration of the original Chilean communities has not prevented the assembly between the native and

  13. Age distributions of Greenlandic dwarf shrubs support concept of negligible actuarial senescence

    DEFF Research Database (Denmark)

    Dahlgren, Johan; Rizzi, Silvia; Schweingruber, Fritz

    2016-01-01

    Many plants and sessile animals may not show actuarial senescence, the increase in mortality with age predicted to be ubiquitous by classic evolutionary theories of aging. Age-structured demographic information is, however, limited for most organisms. We assessed the age distributions of nine dwarf...... to be an important variable for making population projections and determining extinction risks....

  14. Normal forms for sub-Lorentzian metrics supported on Engel type distributions

    Science.gov (United States)

    Grochowski, Marek

    2014-06-01

    We construct normal forms for Lorentzian metrics on Engel distributions under the assumption that abnormal curves are timelike future directed Hamiltonian geodesics. Then we indicate some cases in which the abnormal timelike future directed curve initiating at the origin is geometrically optimal. We also give certain estimates for reachable sets from a point.

  15. Supporting the Construction of Workflows for Biodiversity Problem-Solving Accessing Secure, Distributed Resources

    Directory of Open Access Journals (Sweden)

    J.S. Pahwa

    2006-01-01

    Full Text Available In the Biodiversity World (BDW project we have created a flexible and extensible Web Services-based Grid environment for biodiversity researchers to solve problems in biodiversity and analyse biodiversity patterns. In this environment, heterogeneous and globally distributed biodiversity-related resources such as data sets and analytical tools are made available to be accessed and assembled by users into workflows to perform complex scientific experiments. One such experiment is bioclimatic modelling of the geographical distribution of individual species using climate variables in order to explain past and future climate-related changes in species distribution. Data sources and analytical tools required for such analysis of species distribution are widely dispersed, available on heterogeneous platforms, present data in different formats and lack inherent interoperability. The present BDW system brings all these disparate units together so that the user can combine tools with little thought as to their original availability, data formats and interoperability. The new prototype BDW system architecture not only brings together heterogeneous resources but also enables utilisation of computational resources and provides a secure access to BDW resources via a federated security model. We describe features of the new BDW system and its security model which enable user authentication from a workflow application as part of workflow execution.

  16. Materiel Distribution: Improving Support to Army Operations in Peace and War

    Science.gov (United States)

    1997-01-01

    service or agency. As a second aspect of our process analysis , we examine the measures of performance used by the system. Performance measures tend...about illogical behavior." As a third dimension of our process analysis , we also examine the impact of constraints on the distribution components. The

  17. Estimation of micronutrient intake distributions: development of methods to support food and nutrition policy making

    NARCIS (Netherlands)

    Verkaik-Kloosterman, J.

    2011-01-01


    Introduction
    Adequate and safe micronutrient intake is important. Both insufficient and excessive intakes should be prevented as these can be associated with negative health effects. Therefore, the population intake distribution will ideally lay between insufficient and excessive intake

  18. Supporting observers during distributed team training: the development of a mobile evaluation system

    NARCIS (Netherlands)

    Berlo, M.P.W. van; Hiemstra, A.M.F.; Hoekstra, W.

    2004-01-01

    Distributed team training, often in joint settings, is becoming more and more important in the military training today. As the teams and training staff are not physically on the same location, special attention should be paid to performance measurement and feedback. The question is what should be me

  19. Conservation principles suspended solids distribution modelling to support ATS introduction on a recirculating WWTP.

    Science.gov (United States)

    Gernaey, Krist V; Nielsen, Marinus K; Thornberg, Dines; Höök, Benny; Munk-Nielsen, Thomas; Ingildsen, Pernille; Jørgensen, Sten Bay

    2004-01-01

    A model for the description of the SS distribution in a full-scale recirculating activated sludge WWTP was developed. The model, based on conservation principles, uses on-line plant data as model inputs, and provides a prediction of the SS load in the inlet to the secondary clarifiers and the SS distribution in the WWTP as outputs. The calibrated model produces excellent predictions of the SS load to the secondary clarifiers, an essential variable for the operation of the aeration tank settling (ATS) process. A case study illustrated how the calibrated SS distribution model can be used to evaluate the potential benefit of ATS implementation on a full-scale recirculating WWTP. A reduction of the maximum SS peak load to the secondary clarifiers with 24.9% was obtained with ATS, whereas the cumulative SS load to the clarifiers is foreseen to be reduced with 22.5% for short rain events (4 hours duration) and with 16.6% for long rain events (24 hours duration). The SS distribution model is a useful tool for off-line studies of the potential benefits to be obtained by introducing ATS on a recirculating WWTP. Finally, the successful operation of the ATS process on the full-scale plant is illustrated with data.

  20. A Distributed Management Scheme for supporting energy-harvested I/O devices

    NARCIS (Netherlands)

    Zand, P.; Das, Kallol; Mathews, E.; Havinga, Paul J.M.

    Current wireless technologies for industrial application, such as WirelessHART and ISA100.11a, are not designed to support harvester-powered input/output (I/O) devices, where energy availability varies in a non-deterministic manner. The centralized management approach of these standards makes it

  1. Distributed scheduling to support a call center: A cooperative multiagent approach

    NARCIS (Netherlands)

    Brazier, F.M.T.; Jonker, C.M.; Jüngen, F.J.; Treur, J.

    1999-01-01

    This article describes a multiagent system architecture to increase the value of 24-hour-a day call center service. This system supports call centers in making appointments with clients on the basis ofknowledge ofemployees and their schedules. Relevant activities are scheduled for employees in prepa

  2. A Grid Middleware for Distributed Java Computing with MPI Binding and Process Migration Supports

    Institute of Scientific and Technical Information of China (English)

    CHEN Lin(陈琳); WANG ChoLi(王卓立); Francis C.M.Lau

    2003-01-01

    "Grid" computing has emerged as an important new research field. With years of efforts, grid researchers have successfully developed grid technologies including security solutions,resource management protocols, information query protocols, and data management services. However, as the ultimate goal of grid computing is to design an infrastructure which supports dynamic,cross-organizational resource sharing, there is a need of solutions for efficient and transparent task re-scheduling in the grid.In this research, a new grid middleware is proposed, called G-JavaMPI. This middleware adds the parallel computing capability of Java to the grid with the support of a Grid-enabled message passing interface (MPI) for inter-process communication between Java processes executed at different grid points. A special feature of the proposed G-JavaMPI is the support of Java process migration with post-migration message redirection. With these supports, it is possible to migrate executing Java process from site to site for continuous computation, if some site is scheduled to be turned down for system reconfiguration. Moreover, the proposed G-JavaMPI middleware is very portable since it requires no modification of underlying OS, Java virtual machine, and MPI package. Preliminary performance tests have been conducted. The proposed mechanisms have shown good migration efficiency in a simulated grid environment.

  3. How Social Software Supports Cooperative Practices in a Globally Distributed Software Project

    DEFF Research Database (Denmark)

    Giuffrida, Rosalba; Dittrich, Yvonne

    2014-01-01

    In Global Software Development (GSD), the lack of face- to-face communication is a major challenge and effective computer-mediated practices are necessary. This paper analyzes cooperative practices supported by Social Software (SoSo) in a GSD student project. The empirical results show...

  4. Enhanced Situational Awareness and Decision Support for Operators of Future Distributed Power Network Architectures

    DEFF Research Database (Denmark)

    Zaher, Ammar S. A. E.; Catterson, V. M.; Syed, M. H.

    2016-01-01

    . The control room visualisation and decision support functionality for aiding the operator in restoring the frequency to its target value will be considered. The analysis takes place within the Web-ofCells framework, adopted to deal with power system control through a web of subsystems, called cells, which...

  5. Distributed Web-Scale Infrastructure For Crawling, Indexing And Search With Semantic Support

    Directory of Open Access Journals (Sweden)

    Stefan Dlugolinsky

    2012-01-01

    Full Text Available In this paper, we describe our work in progress in the scope of web-scale informationextraction and information retrieval utilizing distributed computing. Wepresent a distributed architecture built on top of the MapReduce paradigm forinformation retrieval, information processing and intelligent search supportedby spatial capabilities. Proposed architecture is focused on crawling documentsin several different formats, information extraction, lightweight semantic annotationof the extracted information, indexing of extracted information andfinally on indexing of documents based on the geo-spatial information foundin a document. We demonstrate the architecture on two use cases, where thefirst is search in job offers retrieved from the LinkedIn portal and the second issearch in BBC news feeds and discuss several problems we had to face duringthe implementation. We also discuss spatial search applications for both casesbecause both LinkedIn job offer pages and BBC news feeds contain a lot of spatialinformation to extract and process.

  6. Distributed Agent-Based Networks in Support of Advanced Marine Corps Command and Control Concept

    Science.gov (United States)

    2012-09-01

    capabilities that Mobile Ad Hoc Networking ( MANET ) technologies can provide to the Marine Corps are just fully coming into view. These new...Management System, NMS, Tactical Mobile Ad hoc Networks, MANET , Agent-based, Policy-Based, Distributed Networks, Autonomic Networks 15. NUMBER OF...ABSTRACT The capabilities that Mobile Ad Hoc Networking ( MANET ) technologies can provide to the Marine Corps are just fully coming into view. These

  7. Integrated Simulation Development and Decision Support Tool-Set for Utility Market and Distributed Solar Power Generation Electricore, Inc.

    Energy Technology Data Exchange (ETDEWEB)

    Daye, Tony [Green Power Labs (GPL), San Diego, CA (United States)

    2013-09-30

    This project will enable utilities to develop long-term strategic plans that integrate high levels of renewable energy generation, and to better plan power system operations under high renewable penetration. The program developed forecast data streams for decision support and effective integration of centralized and distributed solar power generation in utility operations. This toolset focused on real time simulation of distributed power generation within utility grids with the emphasis on potential applications in day ahead (market) and real time (reliability) utility operations. The project team developed and demonstrated methodologies for quantifying the impact of distributed solar generation on core utility operations, identified protocols for internal data communication requirements, and worked with utility personnel to adapt the new distributed generation (DG) forecasts seamlessly within existing Load and Generation procedures through a sophisticated DMS. This project supported the objectives of the SunShot Initiative and SUNRISE by enabling core utility operations to enhance their simulation capability to analyze and prepare for the impacts of high penetrations of solar on the power grid. The impact of high penetration solar PV on utility operations is not only limited to control centers, but across many core operations. Benefits of an enhanced DMS using state-of-the-art solar forecast data were demonstrated within this project and have had an immediate direct operational cost savings for Energy Marketing for Day Ahead generation commitments, Real Time Operations, Load Forecasting (at an aggregate system level for Day Ahead), Demand Response, Long term Planning (asset management), Distribution Operations, and core ancillary services as required for balancing and reliability. This provided power system operators with the necessary tools and processes to operate the grid in a reliable manner under high renewable penetration.

  8. DEPENDENCE OF THE DISTRIBUTION OF ACTIVE CENTERS ON MONOMER IN SUPPORTED ZIEGLER-NATTA CATALYSTS

    Institute of Scientific and Technical Information of China (English)

    Le-tian Zhang; Zhi-qiang Fan; Zhi-sheng Fu

    2008-01-01

    Distribution of active centers(ACD)of ethylene or 1-hexene homopolymerization and ethylene-1-hexene copolymerization with a MgCl2/TiCl4 type Z-N catalyst were studied by deconvolution of the polymer molecular weight distribution into multiple Flory components.Each Flory component is thought to be formed by a certain type of active center.ACD of ethylene-1-hexene copolymer with very low 1-hexene incorporation was compared with that of ethylene homopolymer to see the effect of introducing a-olefin on ethylene polymerization.On the other hand.ACD of ethylene-1-hexene copolymer with very low ethylene incorporation was compared with that of 1-hexene homopolymer.Adding small amount of 1-hexene in ethylene polymerization caused marked activation of all the Flory components of the polymer.in which the low molecular weight components are activated more than the high molecular weight components.In 1-hexene polymerization system,the activity can also be greatly enhanced by introducing small amount of ethylene.but the different Flory components(or active centers) are activated with similar extent,except a newly emerged active center producing polymer with the lowest molecular weight.The total number of active centers is markedly increased by adding small amount of ethylene in 1-hexene polymerization,but the average catalysis efficiency of the active centers decreased.The broad composition distribution of the ethylene-1-hexene copolymer Can be well understood from the ACD of catalyst and is dependence on the monomer.

  9. Past and ongoing shifts in Joshua tree distribution support future modeled range contraction

    Science.gov (United States)

    Cole, Kenneth L.; Ironside, Kirsten; Eischeid, Jon K.; Garfin, Gregg; Duffy, Phil; Toney, Chris

    2011-01-01

    The future distribution of the Joshua tree (Yucca brevifolia) is projected by combining a geostatistical analysis of 20th-century climates over its current range, future modeled climates, and paleoecological data showing its response to a past similar climate change. As climate rapidly warmed ;11 700 years ago, the range of Joshua tree contracted, leaving only the populations near what had been its northernmost limit. Its ability to spread northward into new suitable habitats after this time may have been inhibited by the somewhat earlier extinction of megafaunal dispersers, especially the Shasta ground sloth. We applied a model of climate suitability for Joshua tree, developed from its 20th-century range and climates, to future climates modeled through a set of six individual general circulation models (GCM) and one suite of 22 models for the late 21st century. All distribution data, observed climate data, and future GCM results were scaled to spatial grids of ;1 km and ;4 km in order to facilitate application within this topographically complex region. All of the models project the future elimination of Joshua tree throughout most of the southern portions of its current range. Although estimates of future monthly precipitation differ between the models, these changes are outweighed by large increases in temperature common to all the models. Only a few populations within the current range are predicted to be sustainable. Several models project significant potential future expansion into new areas beyond the current range, but the species' Historical and current rates of dispersal would seem to prevent natural expansion into these new areas. Several areas are predicted to be potential sites for relocation/ assisted migration. This project demonstrates how information from paleoecology and modern ecology can be integrated in order to understand ongoing processes and future distributions.

  10. A Review of Decision Support Models for Global Distribution Network Design and Future Model development

    DEFF Research Database (Denmark)

    Reich, Juri; Kinra, Aseem; Kotzab, Herbert

    not offer a comprehensive method that is able to solve the problem in one single decision making process considering all relevant goals and factors. Thus, we attempt to create such a model using existing methods as building blocks, namely mixedinteger linear programming and the analytical hierarchy process.......We look at the global distribution network design problem and the requirements to solve it. This problem typically involves conflicting goals and a magnitude of interdependent input factors, described by qualitative and quantitative information. Our literature review shows that current models do...

  11. Bayesian network as a support tool for rapid query of the environmental multimedia distribution of nanomaterials.

    Science.gov (United States)

    Bilal, Muhammad; Liu, Haven; Liu, Rong; Cohen, Yoram

    2017-03-10

    An approach is presented describing the development of a Bayesian network (BN) based tool for rapid assessment of the distribution of engineered nanomaterials (ENMs). The methodology was demonstrated via the construction of a BN model for estimating the exposure concentrations of nanomaterials (BN-nanoExpo) based on simulation data derived from a mechanistic multimedia compartmental fate and transport model. The results of simulations of the distribution of six ENMs in eight different regions were generated for a broad range of geographical and meteorological parameters as well as ENM release rates to the air, water and soil major compartments. Test cases with the constructed BN-nanoExpo demonstrated the capability of the BN based model to portray a wide range of simulation results that can be obtained with the mechanistic fate and transport model. Moreover, BN-nanoExpo is shown to be a suitable tool for estimating both ENM concentrations and release rates given partial information, while also enabling assessment of the impact of uncertainties in input data on the predicted outcomes. The results of the current study suggest that there is merit in exploring the utility of the approach to more complex models, which would provide decision makers with powerful tools for rapid assessment of the behavior of nanomaterials in the environment.

  12. Airborne lidar mapping of vertical ozone distributions in support of the 1990 Clean Air Act Amendments

    Science.gov (United States)

    Uthe, Edward E.; Nielsen, Norman B.; Livingston, John M.

    1992-01-01

    The 1990 Clean Air Act Amendments mandated attainment of the ozone standard established by the U.S. Environmental Protection Agency. Improved photochemical models validated by experimental data are needed to develop strategies for reducing near surface ozone concentrations downwind of urban and industrial centers. For more than 10 years, lidar has been used on large aircraft to provide unique information on ozone distributions in the atmosphere. However, compact airborne lidar systems are needed for operation on small aircraft of the type typically used on regional air quality investigations to collect data with which to develop and validate air quality models. Data presented in this paper will consist of a comparison between airborne differential absorption lidar (DIAL) and airborne in-situ ozone measurements. Also discussed are future plans to improve the airborne ultraviolet-DIAL for ozone and other gas observations and addition of a Fourier Transform Infrared (FTIR) emission spectrometer to investigate the effects of other gas species on vertical ozone distribution.

  13. Distributed multimedia database technologies supported by MPEG-7 and MPEG-21

    CERN Document Server

    Kosch, Harald

    2003-01-01

    15 Introduction Multimedia Content: Context Multimedia Systems and Databases (Multi)Media Data and Multimedia Metadata Purpose and Organization of the Book MPEG-7: The Multimedia Content Description Standard Introduction MPEG-7 and Multimedia Database Systems Principles for Creating MPEG-7 Documents MPEG-7 Description Definition Language Step-by-Step Approach for Creating an MPEG-7 Document Extending the Description Schema of MPEG-7 Encoding and Decoding of MPEG-7 Documents for Delivery-Binary Format for MPEG-7 Audio Part of MPEG-7 MPEG-7 Supporting Tools and Referen

  14. Cardea: Providing Support for Dynamic Resource Access in a Distributed Computing Environment

    Science.gov (United States)

    Lepro, Rebekah

    2003-01-01

    The environment framing the modem authorization process span domains of administration, relies on many different authentication sources, and manages complex attributes as part of the authorization process. Cardea facilitates dynamic access control within this environment as a central function of an inter-operable authorization framework. The system departs from the traditional authorization model by separating the authentication and authorization processes, distributing the responsibility for authorization data and allowing collaborating domains to retain control over their implementation mechanisms. Critical features of the system architecture and its handling of the authorization process differentiate the system from existing authorization components by addressing common needs not adequately addressed by existing systems. Continuing system research seeks to enhance the implementation of the current authorization model employed in Cardea, increase the robustness of current features, further the framework for establishing trust and promote interoperability with existing security mechanisms.

  15. On some sufficient conditions for distributed Quality-of-Service support in wireless networks

    CERN Document Server

    Ganesan, Ashwin

    2009-01-01

    Given a wireless network where some pairs of communication links interfere with each other, we study sufficient conditions for determining whether a given set of minimum bandwidth Quality of Service (QoS) requirements can be satisfied. We are especially interested in algorithms which have low communication overhead and low processing complexity. The interference in the network is modeled using a conflict graph whose vertices are the communication links in the network. Two links are adjacent in this graph if and only if they interfere with each other due to being in the same vicinity and hence cannot be simultaneously active. The problem of scheduling the transmission of the various links is then essentially a fractional, weighted vertex coloring problem, for which upper bounds on the fractional chromatic number are sought using only localized information. We present some distributed algorithms for this problem, and discuss their worst-case performance. These algorithms are seen to be within a bounded factor a...

  16. An RFID-Based Manufacturing Control Framework for Loosely Coupled Distributed Manufacturing System Supporting Mass Customization

    Science.gov (United States)

    Chen, Ruey-Shun; Tsai, Yung-Shun; Tu, Arthur

    In this study we propose a manufacturing control framework based on radio-frequency identification (RFID) technology and a distributed information system to construct a mass-customization production process in a loosely coupled shop-floor control environment. On the basis of this framework, we developed RFID middleware and an integrated information system for tracking and controlling the manufacturing process flow. A bicycle manufacturer was used to demonstrate the prototype system. The findings of this study were that the proposed framework can improve the visibility and traceability of the manufacturing process as well as enhance process quality control and real-time production pedigree access. Using this framework, an enterprise can easily integrate an RFID-based system into its manufacturing environment to facilitate mass customization and a just-in-time production model.

  17. Conservation principles suspended solids distribution modeling to support ATS introduction on a recirculating WWTP

    DEFF Research Database (Denmark)

    Gernaey, Krist Victor Bernard; Nielsen, M.K.; Thornberg, D.;

    2004-01-01

    the potential benefit of ATS implementation on a full-scale recirculating WWTP. A reduction of the maximum SS peak load to the secondary clarifiers with 24.9% was obtained with ATS, whereas the cumulative SS load to the clarifiers is foreseen to be reduced with 22.5% for short rain events (4 hours duration......) and with 16.6% for long rain events (24 hours duration). The SS distribution model is a useful tool for off-line studies of the potential benefits to be obtained by introducing ATS on a recirculating WWTP. Finally, the successful operation of the ATS process on the full-scale plant is illustrated with data....

  18. Risk analysis for decision support in electricity distribution system asset management: methods and frameworks for analysing intangible risks

    Energy Technology Data Exchange (ETDEWEB)

    Nordgaard, Dag Eirik

    2010-04-15

    During the last 10 to 15 years electricity distribution companies throughout the world have been ever more focused on asset management as the guiding principle for their activities. Within asset management, risk is a key issue for distribution companies, together with handling of cost and performance. There is now an increased awareness of the need to include risk analyses into the companies' decision making processes. Much of the work on risk in electricity distribution systems has focused on aspects of reliability. This is understandable, since it is surely an important feature of the product delivered by the electricity distribution infrastructure, and it is high on the agenda for regulatory authorities in many countries. However, electricity distribution companies are also concerned with other risks relevant for their decision making. This typically involves intangible risks, such as safety, environmental impacts and company reputation. In contrast to the numerous methodologies developed for reliability risk analysis, there are relatively few applications of structured analyses to support decisions concerning intangible risks, even though they represent an important motivation for decisions taken in electricity distribution companies. The overall objective of this PhD work has been to explore risk analysis methods that can be used to improve and support decision making in electricity distribution system asset management, with an emphasis on the analysis of intangible risks. The main contributions of this thesis can be summarised as: An exploration and testing of quantitative risk analysis (QRA) methods to support decisions concerning intangible risks; The development of a procedure for using life curve models to provide input to QRA models; The development of a framework for risk-informed decision making where QRA are used to analyse selected problems; In addition, the results contribute to clarify the basic concepts of risk, and highlight challenges

  19. A Mechanism Supporting the Client/Server Relationship in the Operating System of Distributed System “THUDS”

    Institute of Scientific and Technical Information of China (English)

    廖先Zhi; 金兰

    1991-01-01

    This paper presents a distributed operating system modeled as an abstract machine that provides all the distributed processes with the same set of services.The kernel of our operating system supports services which are achieved by a remote procedure call on requests by parallel processes.Therefore,a scheme for solving the client-server relationship is required.In our system there are more than one clients and,at least,a receive would be required for each.Similarly,there are more than one servers such that the send in a client should produce a message that can be received by every server.Consequently,a mechanism well suited for programming multiple-clients/single-server and single-client/multiple-servers interactions is proposed.

  20. Synthesis of supported bimetallic nanoparticles with controlled size and composition distributions for active site elucidation

    Energy Technology Data Exchange (ETDEWEB)

    Hakim, Sikander H.; Sener, Canan; Alba Rubio, Ana C.; Gostanian, Thomas M.; O' neill, Brandon J; Ribeiro, Fabio H.; Miller, Jeffrey T.; Dumesic, James A

    2015-08-01

    Elucidation of active sites in supported bimetallic catalysts is complicated by the high level of dispersity in the nanoparticle size and composition that is inherent in conventional methods of catalyst preparation. We present a synthesis strategy that leads to highly dispersed, bimetallic nanoparticles with uniform particle size and composition by means of controlled surface reactions. We demonstrate the synthesis of three systems, RhMo, PtMo, and RhRe, consisting of a highly reducible metal with an oxophilic promoter. These catalysts are characterized by FTIR, CO chemisorption, STEM/EDS, TPR, and XAS analysis. The catalytic properties of these bimetallic nanoparticles were probed for the selective CO hydrogenolysis of (hydroxymethyl)tetrahydropyran to produce 1,6 hexanediol. Based on the characterization results and reactivity trends, the active sites in the hydrogenolysis reaction are identified to be small ensembles of the more noble metal (Rh, Pt) adjacent to highly reduced moieties of the more oxophilic metal (Mo, Re).

  1. Technophiles to Newbies: The Challenge of Supporting Distributed Teams to Maintain Engagement in Virtual Worlds

    Science.gov (United States)

    Griffith, Karen

    2011-01-01

    The purpose of this paper is to look for links in a virtual trainee's interest and self-efficacy in a simulated event as it relates to their previous self-reported technical skill level. Ultimately, the idea would be to provide the right amount of support at the right place at the right time to set the conditions for maximum transfer of the skill sets to the work place. An anecdotal recap of a recent experiment of a medium-scale training event produced in a virtual world will provide examples for discussion. In July 2010, a virtual training event was produced for the Air Force Research Lab's Games for Team Training (GaMeTT) at the Patriot Exercise at Volk Field in Wisconsin. There were 29 EMEDS participants who completed the simulated OCO event using the OLIVE gaming engine. Approximately 25 avatars were present at any given time; including role players, observers, coordinators and participants.

  2. Data in support of DPF2 regulates OCT4 protein level and nuclear distribution

    Directory of Open Access Journals (Sweden)

    Chao Liu

    2015-12-01

    Full Text Available DPF2, also named ubi-d4/requiem (REQU, interacts with a protein complex containing OCT4. This paper provides data in support of the research article entitled “DPF2 regulates OCT4 protein level and nuclear distribution”. The highlights include: (1 Denature-immunoprecipitation assay revealed ubiquitination of OCT4 in pluripotent H9 cells, which was enhancedby MG132, a proteasome inhibitor. (2 Well colocalization of ectopic OCT4 and FLAG-Ub was found in HeLa cells, which was also increased by MG132. (3 MG132 treatment decreased DPF2 cytoplasmic expression in vivo. These data give insights into how proteasome inhibition contributes to studying ubiquitnation of OCT4.

  3. Learner support in a distributed learning environment:the use of WWW-based teachware packages

    Directory of Open Access Journals (Sweden)

    Christian Langenbach

    1997-01-01

    Full Text Available Various forms of education and training, based on the classical Computer Based Training (CBT, have become well established within companies and in higher education. With regard to the flexibility in terms of time and location, as well as in terms of incurred cost, they are far superior to traditional forms of instruction. A relatively recent development which has not yet gained widespread acceptance is the use of the World Wide Web (WWW as a basis and platform for distributed computer assisted teaching and learning. In addition to the advantages outlined with regard to classical CBT, the WWW offers the two advantages of world wide availablity as well as ease of promptly updating courses, but also adds many possibilities of collaborative learning. Using the Java programming language and the ever improving means of online presentation it has become possible to realize sophisticated WWW-based teachware packages which are comparable in terms of appearance and functionality to classical CBT applications created with dedicated authoring systems.

  4. Supporting human interaction and human resources coordination in distributed clinical guidelines.

    Science.gov (United States)

    Bottrighi, Alessio; Torchio, Mauro; Montani, Stefania; Molino, Gianpaolo; Terenziani, Paolo

    2010-01-01

    Clinical guidelines (GL) play an important role in medical practice: the one of optimizing the quality of patient care on the basis of the best and most recent evidence based medicine. In order to achieve this goal, the interaction between different actors, who cooperate in the execution of the same GL, is a crucial issue. As a matter of fact, in many cases (e.g. in chronic disease treatment) the GL execution requires that patient treatment is not performed/completed in the hospital, but is continued in different contexts (e.g. at home, or in the general practitioner's ambulatory), under the responsibility of different actors. In this situation, the correct interaction and communication between the actors themselves is critical for the quality of care, and human resources coordination is a key issue to be addressed by the managers of the involved healthcare service. In this paper we describe how computerized GL management can be extended in order to support such needs, and we illustrate our approach by means of a practical case study.

  5. Phylogenetic distribution of compatible solute synthesis genes support a freshwater origin for cyanobacteria.

    Science.gov (United States)

    Blank, Carrine E

    2013-10-01

    Previous work using ancestral state reconstruction of habitat salinity preference proposed that the early cyanobacteria likely lived in a freshwater environment. The aim of this study was to test that hypothesis by performing phylogenetic analyses of the genes underlying salinity preferences in the cyanobacteria. Phylogenetic analysis of compatible solute genes shows that sucrose synthesis genes were likely ancestral in the cyanobacteria, and were also likely inherited during the cyanobacterial endosymbiosis and into the photosynthetic algae and land plants. In addition, the genes for the synthesis of compatible solutes that are necessary for survival in marine and hypersaline environments (such as glucosylglycerol, glucosylglycerate, and glycine betaine) were likely acquired independently high up (i.e., more recently) in the cyanobacterial tree. Because sucrose synthesis is strongly associated with growth in a low salinity environment, this independently supports a freshwater origin for the cyanobacteria. It is also consistent with geologic evidence showing that the early oceans were much warmer and saltier than modern oceans-sucrose synthesis alone would have been insufficient for early cyanobacteria to have colonized early Precambrian oceans that had a higher ionic strength. Indeed, the acquisition of an expanded set of new compatible solute genes may have enabled the historical colonization of marine and hypersaline environments by cyanobacteria, midway through their evolutionary history.

  6. Randomly and Non-Randomly Missing Renal Function Data in the Strong Heart Study: A Comparison of Imputation Methods.

    Science.gov (United States)

    Shara, Nawar; Yassin, Sayf A; Valaitis, Eduardas; Wang, Hong; Howard, Barbara V; Wang, Wenyu; Lee, Elisa T; Umans, Jason G

    2015-01-01

    Kidney and cardiovascular disease are widespread among populations with high prevalence of diabetes, such as American Indians participating in the Strong Heart Study (SHS). Studying these conditions simultaneously in longitudinal studies is challenging, because the morbidity and mortality associated with these diseases result in missing data, and these data are likely not missing at random. When such data are merely excluded, study findings may be compromised. In this article, a subset of 2264 participants with complete renal function data from Strong Heart Exams 1 (1989-1991), 2 (1993-1995), and 3 (1998-1999) was used to examine the performance of five methods used to impute missing data: listwise deletion, mean of serial measures, adjacent value, multiple imputation, and pattern-mixture. Three missing at random models and one non-missing at random model were used to compare the performance of the imputation techniques on randomly and non-randomly missing data. The pattern-mixture method was found to perform best for imputing renal function data that were not missing at random. Determining whether data are missing at random or not can help in choosing the imputation method that will provide the most accurate results.

  7. Non-random spatial coupling induces desynchronization, chaos and multistability in a predator-prey-resource system.

    Science.gov (United States)

    Suzuki, Kenta; Yoshida, Takehito

    2012-05-07

    The metacommunity perspective has attracted much attention recently, but the understanding of how dispersal between local communities alters their ecological dynamics is still limited, especially regarding the effect of non-random, unequal dispersal of organisms. This is a study of a three-trophic-level (predator-prey-resource) system that is connected by different manners of dispersal. The model is based on a well-studied experimental system cultured in chemostats (continuous flow-through culture), which consists of rotifer predator, algal prey and nutrient. In the model, nutrient dispersal can give rise to multistability when the two systems are connected by nutrient dispersal, whereas three-trophic-level systems tend to show a rich dynamical behavior, e.g. antisynchronous or asynchronous oscillations including chaos. Although the existence of multistability was already known in two-trophic-level (predator-prey) systems, it was confined to a small range of dispersal rate. In contrast, the multistability in the three-trophic-level system is found in a broader range of dispersal rate. The results suggest that, in three-trophic-level systems, the dispersal of nutrient not only alters population dynamics of local systems but can also cause regime shifts such as a transition to different oscillation phases.

  8. Randomly and Non-Randomly Missing Renal Function Data in the Strong Heart Study: A Comparison of Imputation Methods.

    Directory of Open Access Journals (Sweden)

    Nawar Shara

    Full Text Available Kidney and cardiovascular disease are widespread among populations with high prevalence of diabetes, such as American Indians participating in the Strong Heart Study (SHS. Studying these conditions simultaneously in longitudinal studies is challenging, because the morbidity and mortality associated with these diseases result in missing data, and these data are likely not missing at random. When such data are merely excluded, study findings may be compromised. In this article, a subset of 2264 participants with complete renal function data from Strong Heart Exams 1 (1989-1991, 2 (1993-1995, and 3 (1998-1999 was used to examine the performance of five methods used to impute missing data: listwise deletion, mean of serial measures, adjacent value, multiple imputation, and pattern-mixture. Three missing at random models and one non-missing at random model were used to compare the performance of the imputation techniques on randomly and non-randomly missing data. The pattern-mixture method was found to perform best for imputing renal function data that were not missing at random. Determining whether data are missing at random or not can help in choosing the imputation method that will provide the most accurate results.

  9. Does balneotherapy with low radon concentration in water influence the endocrine system? A controlled non-randomized pilot study.

    Science.gov (United States)

    Nagy, Katalin; Berhés, István; Kovács, Tibor; Kávási, Norbert; Somlai, János; Bender, Tamás

    2009-08-01

    Radon bath is a well-established modality of balneotherapy for the management of degenerative musculoskeletal disorders. The present study was conducted to ascertain whether baths of relatively low (80 Bq/l) radon concentration have any influence on the functioning of the endocrine system. In the study, a non-randomized pilot study, 27 patients with degenerative musculoskeletal disorders received 30-min radon baths (of 31-32 degrees C temperature and 80 Bq/l average radon concentration) daily, for 15 days. Twenty-five patients with matching pathologies were subjected to balneotherapy according to the same protocol, using thermal water with negligible radon content (6 Bq/l). Serum thyroid stimulating hormone, prolactin, cortisol, adrenocorticotropic hormone, and dehydroepiandrosterone levels were measured before and after a balneotherapy course of 15 sessions. Comparison of the accumulated data using the Wilcoxon test did not reveal any significant difference between pre- and post-treatment values or between the two patient groups. It is noted that while the beneficial effects of balneotherapy with radon-containing water on degenerative disorders is widely known, only few data have been published in the literature on its effect on endocrine functions. The present study failed to demonstrate any substantial effect of thermal water with relatively low radon content on the functioning of the endocrine system.

  10. Botulinum toxin injection versus lateral internal sphincterotomy in the treatment of chronic anal fissure: a non-randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Ulusoy Nefise B

    2004-03-01

    Full Text Available Abstract Background Although lateral internal sphincterotomy is the gold-standard treatment for chronic anal fissure, intrasphincteric injection of botulinum toxin seems to be a reliable new option. The aim of this non-randomized study is to compare the effect of lateral internal sphincterotomy and botulinum toxin injection treatments on the outcome and reduction of anal sphincter pressures in patients with chronic anal fissure. Methods Patients with chronic anal fissure were treated with either botulinum toxin injection or lateral internal sphincterotomy by their own choice. Maximal resting pressure and maximal squeeze pressure measurements were performed before and 2 weeks after treatments by anal manometry. Patients were followed for fissure relapse during 14 months. Results Twenty-one consecutive outpatients with posterior chronic anal fissure were enrolled. Eleven patients underwent surgery and ten patients received botulinum toxin injection treatment. Before the treatment, anal pressures were found to be similar in both groups. After the treatment, the maximal resting pressures were reduced from 104 ± 22 mmHg to 86 ± 15 mmHg in the surgery group (p 0.05 in the surgery group, and from 117 ± 62 mmHg to 76 ± 34 (p 0.05. There were no relapses during the 14 months of follow up. Conclusion Lateral internal sphincterotomy and botulinum toxin injection treatments both seem to be equally effective in the treatment of chronic anal fissure.

  11. Systems-level chromosomal parameters represent a suprachromosomal basis for the non-random chromosomal arrangement in human interphase nuclei

    Science.gov (United States)

    Fatakia, Sarosh N.; Mehta, Ishita S.; Rao, Basuthkar J.

    2016-01-01

    Forty-six chromosome territories (CTs) are positioned uniquely in human interphase nuclei, wherein each of their positions can range from the centre of the nucleus to its periphery. A non-empirical basis for their non-random arrangement remains unreported. Here, we derive a suprachromosomal basis of that overall arrangement (which we refer to as a CT constellation), and report a hierarchical nature of the same. Using matrix algebra, we unify intrinsic chromosomal parameters (e.g., chromosomal length, gene density, the number of genes per chromosome), to derive an extrinsic effective gene density matrix, the hierarchy of which is dominated largely by extrinsic mathematical coupling of HSA19, followed by HSA17 (human chromosome 19 and 17, both preferentially interior CTs) with all CTs. We corroborate predicted constellations and effective gene density hierarchy with published reports from fluorescent in situ hybridization based microscopy and Hi-C techniques, and delineate analogous hierarchy in disparate vertebrates. Our theory accurately predicts CTs localised to the nuclear interior, which interestingly share conserved synteny with HSA19 and/or HSA17. Finally, the effective gene density hierarchy dictates how permutations among CT position represents the plasticity within its constellations, based on which we suggest that a differential mix of coding with noncoding genome modulates the same. PMID:27845379

  12. Azacytidine and decitabine induce gene-specific and non-random DNA demethylation in human cancer cell lines.

    Directory of Open Access Journals (Sweden)

    Sabine Hagemann

    Full Text Available The DNA methyltransferase inhibitors azacytidine and decitabine represent archetypal drugs for epigenetic cancer therapy. To characterize the demethylating activity of azacytidine and decitabine we treated colon cancer and leukemic cells with both drugs and used array-based DNA methylation analysis of more than 14,000 gene promoters. Additionally, drug-induced demethylation was compared to methylation patterns of isogenic colon cancer cells lacking both DNA methyltransferase 1 (DNMT1 and DNMT3B. We show that drug-induced demethylation patterns are highly specific, non-random and reproducible, indicating targeted remethylation of specific loci after replication. Correspondingly, we found that CG dinucleotides within CG islands became preferentially remethylated, indicating a role for DNA sequence context. We also identified a subset of genes that were never demethylated by drug treatment, either in colon cancer or in leukemic cell lines. These demethylation-resistant genes were enriched for Polycomb Repressive Complex 2 components in embryonic stem cells and for transcription factor binding motifs not present in demethylated genes. Our results provide detailed insights into the DNA methylation patterns induced by azacytidine and decitabine and suggest the involvement of complex regulatory mechanisms in drug-induced DNA demethylation.

  13. Analytical approaches to support current understanding of exposure, uptake and distributions of engineered nanoparticles by aquatic and terrestrial organisms.

    Science.gov (United States)

    Schultz, Carolin; Powell, Kate; Crossley, Alison; Jurkschat, Kerstin; Kille, Peter; Morgan, A John; Read, Daniel; Tyne, William; Lahive, Elma; Svendsen, Claus; Spurgeon, David J

    2015-03-01

    Initiatives to support the sustainable development of the nanotechnology sector have led to rapid growth in research on the environmental fate, hazards and risk of engineered nanoparticles (ENP). As the field has matured over the last 10 years, a detailed picture of the best methods to track potential forms of exposure, their uptake routes and best methods to identify and track internal fate and distributions following assimilation into organisms has begun to emerge. Here we summarise the current state of the field, focussing particularly on metal and metal oxide ENPs. Studies to date have shown that ENPs undergo a range of physical and chemical transformations in the environment to the extent that exposures to pristine well dispersed materials will occur only rarely in nature. Methods to track assimilation and internal distributions must, therefore, be capable of detecting these modified forms. The uptake mechanisms involved in ENP assimilation may include a range of trans-cellular trafficking and distribution pathways, which can be followed by passage to intracellular compartments. To trace toxicokinetics and distributions, analytical and imaging approaches are available to determine rates, states and forms. When used hierarchically, these tools can map ENP distributions to specific target organs, cell types and organelles, such as endosomes, caveolae and lysosomes and assess speciation states. The first decade of ENP ecotoxicology research, thus, points to an emerging paradigm where exposure is to transformed materials transported into tissues and cells via passive and active pathways within which they can be assimilated and therein identified using a tiered analytical and imaging approach.

  14. Evolving Distributed Generation Support Mechanisms: Case Studies from United States, Germany, United Kingdom, and Australia (Chinese translation)

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Shengru [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Lowder, Travis R [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Tian, Tian [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-09-07

    This is the Chinese translation of NREL/TP-6A20-67613. This report expands on a previous National Renewable Energy Laboratory (NREL) technical report (Lowder et al. 2015) that focused on the United States' unique approach to distributed generation photovoltaics (DGPV) support policies and business models. While the focus of that report was largely historical (i.e., detailing the policies and market developments that led to the growth of DGPV in the United States), this report looks forward, narrating recent changes to laws and regulations as well as the ongoing dialogues over how to incorporate distributed generation (DG) resources onto the electric grid. This report also broadens the scope of Lowder et al. (2015) to include additional countries and technologies. DGPV and storage are the principal technologies under consideration (owing to market readiness and deployment volumes), but the report also contemplates any generation resource that is (1) on the customer side of the meter, (2) used to, at least partly, offset a host's energy consumption, and/or (3) potentially available to provide grid support (e.g., through peak shaving and load shifting, ancillary services, and other means).

  15. Effect of the state of distribution of supported Pt nanoparticles on effective Pt utilization in polymer electrolyte fuel cells.

    Science.gov (United States)

    Uchida, Makoto; Park, Young-Chul; Kakinuma, Katsuyoshi; Yano, Hiroshi; Tryk, Donald A; Kamino, Takeo; Uchida, Hiroyuki; Watanabe, Masahiro

    2013-07-21

    In polymer electrolyte fuel cells, it is essential to minimize Pt loading, particularly at the cathode, without serious loss of performance. From this point of view, we will report an advanced concept for the design of high performance catalysts and membrane-electrode assemblies (MEAs): first, the evaluation of Pt particle distributions on both the interior and exterior walls of various types of carbon black (CB) particles used as supports with respect to the "effective surface (ES)"; second, control of both size and location of Pt particles by means of a new preparation method (nanocapsule method); and finally, a new evaluation method for the properties of MEAs based on the Pt utilization (UPt), mass activity (MA), and effectiveness of Pt (EfPt), based on the ES concept. The amounts of Pt catalyst particles located in the CB nanopores were directly evaluated using the transmission electron microscopy, scanning electron microscopy and corresponding three-dimensional images. By use of the nanocapsule method and optimization of the ionomer, increased MA and EfPt values for the MEA were achieved. The improvement in the cathode performance can be attributed to the sharp particle-size distribution for Pt and the highly uniform dispersion on the exterior surface of graphitized carbon black (GCB) supports.

  16. Analysis of emplaced waste data and implications of non-random emplacement for performance assessment for the WIPP

    Energy Technology Data Exchange (ETDEWEB)

    Allen, Lawrence E.; Channell, James K.

    2003-05-31

    The WIPP Land Withdrawal Act recognized that after the initial certification of the WIPP and start of disposal operations, operating experience and ongoing research would result in new technical and scientific information. The Environmental Evaluation Group (EEG) has previously reported on issues that it considers important as the Department of Energy (DOE) works towards the first recertification. One of these issues involves the assumption of random emplacement of waste used in the performance assessment calculations in support of the initial certification application. As actual waste emplacement data are now available from four years of disposal, the EEG performed an analysis to evaluate the validity of that initial assumption and determine implications for performance assessment. Panel 1 was closed in March 2003. The degree of deviation between actual emplaced waste in Panel 1 and an assumption of random emplacement is apparent with concentrations of 239Pu being 3.20 times, 240Pu being 2.67 times, and 241Am being 4.13 times the projected repository average for the space occupied by the waste. A spatial statistical analysis was performed using available Panel 1 data retrieved from the WWIS and assigned room coordinates by Sandia National Laboratories. A comparison was made between the waste as emplaced and a randomization of the same waste. Conversely, the distribution of waste as emplaced is similar to the distribution of waste in the individual containers and can be characterized as bi-modal and skewed with a long high-concentration tail. The distribution of randomized waste is fairly symmetrical, as would be expected from classical statistical theory. In the event of a future drilling intrusion, comparison of these two distributions shows a higher probability of intersecting a high-concentration stack of the actual emplaced waste, over that of the same waste emplaced in a randomized manner as was assumed in the certified

  17. Using Cape Sable seaside sparrow distribution data for water management decision support

    Science.gov (United States)

    Beerens, James; Romanach, Stephanie

    2016-01-01

    identifying factors affecting sparrow habitat suitability and expanding the total area of suitable habitat over a gradient of environmental conditions. Our objective is to improve the definition of suitable sparrow habitat based on the relationship between daily sparrow distributions from 1992-present and hydrologic and habitat variables. Further, these models can provide an estimate of habitat quality when linked with estimates of reproductive responses.

  18. Periodontal ligament influence on the stress distribution in a removable partial denture supported by implant: a finite element analysis

    Directory of Open Access Journals (Sweden)

    Carlos Marcelo Archangelo

    2012-06-01

    Full Text Available OBJECTIVES: The non-homogenous aspect of periodontal ligament (PDL has been examined using finite element analysis (FEA to better simulate PDL behavior. The aim of this study was to assess, by 2-D FEA, the influence of non-homogenous PDL on the stress distribution when the free-end saddle removable partial denture (RPD is partially supported by an osseointegrated implant. MATERIAL AND METHODS: Six finite element (FE models of a partially edentulous mandible were created to represent two types of PDL (non-homogenous and homogenous and two types of RPD (conventional RPD, supported by tooth and fibromucosa; and modified RPD, supported by tooth and implant [10.00x3.75 mm]. Two additional Fe models without RPD were used as control models. The non-homogenous PDL was modeled using beam elements to simulate the crest, horizontal, oblique and apical fibers. The load (50 N was applied in each cusp simultaneously. Regarding boundary conditions the border of alveolar ridge was fixed along the x axis. The FE software (Ansys 10.0 was used to compute the stress fields, and the von Mises stress criterion (svM was applied to analyze the results. RESULTS: The peak of svM in non-homogenous PDL was higher than that for the homogenous condition. The benefits of implants were enhanced for the non-homogenous PDL condition, with drastic svM reduction on the posterior half of the alveolar ridge. The implant did not reduce the stress on the support tooth for both PDL conditions. Conclusion: The PDL modeled in the non-homogeneous form increased the benefits of the osseointegrated implant in comparison with the homogeneous condition. Using the non-homogenous PDL, the presence of osseointegrated implant did not reduce the stress on the supporting tooth.

  19. Influence of finish line in the distribution of stress trough an all ceramic implant-supported crown.

    Science.gov (United States)

    SANNINO, G.; GLORIA, F.; OTTRIA, L.; BARLATTANI, A.

    2010-01-01

    SUMMARY Porpose. The aim of this study was to evaluate, by finite element analysis (FEA), the influence of finish line on stress distribution and resistance to the loads of a ZrO2 crown and porcelain in implant-supported. Material and methods. The object of this analysis consisted of a fxture, an abutment, a passing screw, a layer of cement, a framework crown, a feldspatic porcelain veneering. The abutment’s marginal design was used in 3 different types of preparation: feather edge, slight chamfer and 50°, each of them was of 1 mm depth over the entire circumference. The ZrO2Y-TZP coping was 0.6 mm thick. Two material matching for the abutment and the framework was used for the simulations: ZrO2 framework and ZrO2 abutment, ZrO2 framework and T abutment. A 600 N axial force distributed over the entire surface of the crown was applied. The numerical simulations with finite elements were used to verify the different distribution of equivalent von Mises stress for three different geometries of abutment and framework. Results Slight chamfer on the matching ZrO2 - ZrO2 is the geometry with minimum equivalent stress of von Mises. Even for T abutment and ZrO2 framework slight chamfer is the best configuration to minimize the localized stress. Geometry that has the highest average stress is one with abutment at 50°, we see a downward trend for all three configurations using only zirconium for both components. Conclusions Finite element analysis. performed for the manifacturing of implant-supported crown, gives exact geometric guide lines about the choice of chamfer preparation, while the analysis of other marginal geometries suggests a possible improved behavior of the mating between ZrO2 abutment and ZrO2 coping. for three different geometries of the abutment and the coping. PMID:23285359

  20. Environmental Transmission Electron Microscopy Study of the Origins of Anomalous Particle Size Distributions in Supported Metal Catalysts

    Energy Technology Data Exchange (ETDEWEB)

    Benavidez, Angelica D.; Kovarik, Libor; Genc, Arda; Agrawal, Nitin; Larsson, Elin M.; Hansen, Thomas W.; Karim, Ayman M.; Datye, Abhaya K.

    2012-10-31

    In this Environmental TEM (ETEM) study of supported Pt and Pd model catalysts, individual nanoparticles were tracked during heat treatments at temperatures up to 600°C in H2, O2, and vacuum. We found anomalous growth of nanoparticles occurred during the early stages of catalyst sintering wherein some particles started to grow significantly larger than the mean, resulting in a broadening of the particle size distribution. We can rule out sample non-uniformity as a cause for the growth of these large particles, since images were recorded prior to heat treatments. The anomalous growth of these particles may help explain particle size distributions in heterogeneous catalysts which often show particles that are significantly larger than the mean, resulting in a long tail to the right. It has been suggested that particle migration and coalescence could be the likely cause for the broad size distributions. This study shows that anomalous growth of nanoparticles can occur under conditions where Ostwald ripening is the primary sintering mechanism.

  1. Issues Relating to Study Design and Risk of Bias When Including Non-Randomized Studies in Systematic Reviews on the Effects of Interventions

    Science.gov (United States)

    Higgins, Julian P. T.; Ramsay, Craig; Reeves, Barnaby C.; Deeks, Jonathan J.; Shea, Beverley; Valentine, Jeffrey C.; Tugwell, Peter; Wells, George

    2013-01-01

    Non-randomized studies may provide valuable evidence on the effects of interventions. They are the main source of evidence on the intended effects of some types of interventions and often provide the only evidence about the effects of interventions on long-term outcomes, rare events or adverse effects. Therefore, systematic reviews on the effects…

  2. Synonymous codon usage in different protein secondary structural classes of human genes: Implication for increased non-randomness of GC3 rich genes towards protein stability

    Indian Academy of Sciences (India)

    Pamela Mukhopadhyay; Surajit Basak; Tapash Chandra Ghosh

    2007-08-01

    The relationship between the synonymous codon usage and different protein secondary structural classes were investigated using 401 Homo sapiens proteins extracted from Protein Data Bank (PDB). A simple Chi-square test was used to assess the significance of deviation of the observed and expected frequencies of 59 codons at the level of individual synonymous families in the four different protein secondary structural classes. It was observed that synonymous codon families show non-randomness in codon usage in four different secondary structural classes. However, when the genes were classified according to their GC3 levels there was an increase in non-randomness in high GC3 group of genes. The non-randomness in codon usage was further tested among the same protein secondary structures belonging to four different protein folding classes of high GC3 group of genes. The results show that in each of the protein secondary structural unit there exist some synonymous family that shows class specific codonusage pattern. Moreover, there is an increased non-random behaviour of synonymous codons in sheet structure of all secondary structural classes in high GC3 group of genes. Biological implications of these results have been discussed.

  3. Issues Relating to Confounding and Meta-analysis When Including Non-Randomized Studies in Systematic Reviews on the Effects of Interventions

    Science.gov (United States)

    Valentine, Jeffrey C.; Thompson, Simon G.

    2013-01-01

    Background: Confounding caused by selection bias is often a key difference between non-randomized studies (NRS) and randomized controlled trials (RCTs) of interventions. Key methodological issues: In this third paper of the series, we consider issues relating to the inclusion of NRS in systematic reviews on the effects of interventions. We discuss…

  4. A framework for a distributed, hybrid, multiple-ontology clinical-guideline library, and automated guideline-support tools.

    Science.gov (United States)

    Shahar, Yuval; Young, Ohad; Shalom, Erez; Galperin, Maya; Mayaffit, Alon; Moskovitch, Robert; Hessing, Alon

    2004-10-01

    Clinical guidelines are a major tool in improving the quality of medical care. However, most guidelines are in free text, not in a formal, executable format, and are not easily accessible to clinicians at the point of care. We introduce a Web-based, modular, distributed architecture, the Digital Electronic Guideline Library (DeGeL), which facilitates gradual conversion of clinical guidelines from text to a formal representation in chosen target guideline ontology. The architecture supports guideline classification, semantic markup, context-sensitive search, browsing, run-time application, and retrospective quality assessment. The DeGeL hybrid meta-ontology includes elements common to all guideline ontologies, such as semantic classification and domain knowledge; it also includes four content-representation formats: free text, semi-structured text, semi-formal representation, and a formal representation. These formats support increasingly sophisticated computational tasks. The DeGeL tools for support of guideline-based care operate, at some level, on all guideline ontologies. We have demonstrated the feasibility of the architecture and the tools for several guideline ontologies, including Asbru and GEM.

  5. Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes.

    Science.gov (United States)

    Stimpson, Kaitlin M; Song, Ihn Young; Jauch, Anna; Holtgreve-Grez, Heidi; Hayden, Karen E; Bridger, Joanna M; Sullivan, Beth A

    2010-08-12

    Genome rearrangement often produces chromosomes with two centromeres (dicentrics) that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, and particularly those in humans, can be quite stable, usually because one centromere is functionally silenced. Molecular mechanisms of centromere inactivation are poorly understood since there are few systems to experimentally create dicentric human chromosomes. Here, we describe a human cell culture model that enriches for de novo dicentrics. We demonstrate that transient disruption of human telomere structure non-randomly produces dicentric fusions involving acrocentric chromosomes. The induced dicentrics vary in structure near fusion breakpoints and like naturally-occurring dicentrics, exhibit various inter-centromeric distances. Many functional dicentrics persist for months after formation. Even those with distantly spaced centromeres remain functionally dicentric for 20 cell generations. Other dicentrics within the population reflect centromere inactivation. In some cases, centromere inactivation occurs by an apparently epigenetic mechanism. In other dicentrics, the size of the alpha-satellite DNA array associated with CENP-A is reduced compared to the same array before dicentric formation. Extra-chromosomal fragments that contained CENP-A often appear in the same cells as dicentrics. Some of these fragments are derived from the same alpha-satellite DNA array as inactivated centromeres. Our results indicate that dicentric human chromosomes undergo alternative fates after formation. Many retain two active centromeres and are stable through multiple cell divisions. Others undergo centromere inactivation. This event occurs within a broad temporal window and can involve deletion of chromatin that marks the locus as a site for CENP-A maintenance/replenishment.

  6. Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes.

    Directory of Open Access Journals (Sweden)

    Kaitlin M Stimpson

    2010-08-01

    Full Text Available Genome rearrangement often produces chromosomes with two centromeres (dicentrics that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, and particularly those in humans, can be quite stable, usually because one centromere is functionally silenced. Molecular mechanisms of centromere inactivation are poorly understood since there are few systems to experimentally create dicentric human chromosomes. Here, we describe a human cell culture model that enriches for de novo dicentrics. We demonstrate that transient disruption of human telomere structure non-randomly produces dicentric fusions involving acrocentric chromosomes. The induced dicentrics vary in structure near fusion breakpoints and like naturally-occurring dicentrics, exhibit various inter-centromeric distances. Many functional dicentrics persist for months after formation. Even those with distantly spaced centromeres remain functionally dicentric for 20 cell generations. Other dicentrics within the population reflect centromere inactivation. In some cases, centromere inactivation occurs by an apparently epigenetic mechanism. In other dicentrics, the size of the alpha-satellite DNA array associated with CENP-A is reduced compared to the same array before dicentric formation. Extra-chromosomal fragments that contained CENP-A often appear in the same cells as dicentrics. Some of these fragments are derived from the same alpha-satellite DNA array as inactivated centromeres. Our results indicate that dicentric human chromosomes undergo alternative fates after formation. Many retain two active centromeres and are stable through multiple cell divisions. Others undergo centromere inactivation. This event occurs within a broad temporal window and can involve deletion of chromatin that marks the locus as a site for CENP-A maintenance/replenishment.

  7. Deep sequencing of the murine Igh repertoire reveals complex regulation of non-random V gene rearrangement frequencies

    Science.gov (United States)

    Choi, Nancy M.; Loguercio, Salvatore; Verma-Gaur, Jiyoti; Degner, Stephanie C.; Torkamani, Ali; Su, Andrew I.; Oltz, Eugene M.; Artyomov, Maxim; Feeney, Ann J.

    2013-01-01

    A diverse antibody repertoire is formed through the rearrangement of V, D, and J segments at the immunoglobulin heavy chain (Igh) loci. The C57BL/6 murine Igh locus has over 100 functional VH gene segments that can recombine to a rearranged DJH. While the non-random usage of VH genes is well documented, it is not clear what elements determine recombination frequency. To answer this question we conducted deep sequencing of 5′-RACE products of the Igh repertoire in pro-B cells, amplified in an unbiased manner. ChIP-seq results for several histone modifications and RNA polymerase II binding, RNA-seq for sense and antisense non-coding germline transcripts, and proximity to CTCF and Rad21 sites were compared to the usage of individual V genes. Computational analyses assessed the relative importance of these various accessibility elements. These elements divide the Igh locus into four epigenetically and transcriptionally distinct domains, and our computational analyses reveal different regulatory mechanisms for each region. Proximal V genes are relatively devoid of active histone marks and non-coding RNA in general, but having a CTCF site near their RSS is critical, suggesting that being positioned near the base of the chromatin loops is important for rearrangement. In contrast, distal V genes have higher levels of histone marks and non-coding RNA, which may compensate for their poorer RSSs and for being distant from CTCF sites. Thus, the Igh locus has evolved a complex system for the regulation of V(D)J rearrangement that is different for each of the four domains that comprise this locus. PMID:23898036

  8. Analysis of load distribution in tooth-implant supported fixed partial dentures by the use of resilient abutment

    Directory of Open Access Journals (Sweden)

    Glišić Mirko

    2016-01-01

    Full Text Available Introduction. Differences between the tooth and implant response to load can lead to many biological and technical implications in the conditions of occlusal forces. Objective. The objective of this study was to analyze load distribution in tooth/implant-supported fixed partial dentures with the use of resilient TSA (Titan Shock Absorber, BoneCare GmbH, Augsburg, Germany abutment and conventional non-resilient abutment using finite element method. Methods. This study presents two basic 3D models. For one model a standard non-resilient abutment is used, and on the implant of the second model a resilient TSA abutment is applied. The virtual model contains drawn contours of tooth, mucous membranes, implant, cortical bones and spongiosa, abutment and suprastructure. The experiment used 500 N of vertical force, applied in three different cases of axial load. Calculations of von Mises equivalent stresses of the tooth root and periodontium, implants and peri-implant tissue were made. Results. For the model to which a non-resilient abutment is applied, maximum stress values in all three cases are observed in the cortical part of the bone (maximum stress value of 49.7 MPa. Measurements of stress and deformation in the bone tissue in the model with application of the resilient TSA abutment demonstrated similar distribution; however, these values are many times lower than in the model with non-resilient TSA abutment (maximum stress value of 28.9 MPa. Conclusion. Application of the resilient TSA abutment results in more equal distribution of stress and deformations in the bone tissue under vertical forces. These values are many times lower than in the model with the non-resilient abutment.

  9. Evaluation of two fiber optic-based solar collection and distribution systems for advanced space life support

    Science.gov (United States)

    Jack, D. A.; Nakamura, T.; Sadler, P.; Cuello, J. L.

    2002-01-01

    Growing plants in an enclosed controlled environment is crucial in developing bioregenerative life-support systems (BLSS) for space applications. The major challenge currently facing a BLSS is the extensive use of highly energy-intensive electric light sources, which leads to substantial energy wastes through heat dissipations by these lamps. An alternative lighting strategy is the use of a solar irradiance collection, transmission, and distribution system (SICTDS). Two types of fiber optic-based SICTDS, a Fresnel-lens Himawari and a parabolic-mirror optical waveguide (OW) lighting system, were evaluated. The overall efficiency for the OW SICTDS of 40.5% exceeded by 75% that for the Himawari of 23.2%. The spectral distributions of the light delivered by the Himawari and the OW SICTDS were almost identical and had practically no difference from that of terrestrial solar radiation. The ratios of photosynthetically active radiation (PAR) to total emitted radiation (k) of 0.39 +/- 0.02 for the Himawari and 0.41 +/- 0.04 for the OW SICTDS were statistically indistinguishable, were not significantly different from that of 0.042 +/- 0.01 for terrestrial solar radiation, and were comparable to that of 0.35 for a high-pressure sodium (HPS) lamp. The coefficients of variation (CV) of 0.34 and 0.39 for PPF distributions, both at 50 mm X 50 mm square grid arrays, corresponding to the Himawari and the OW SICTDS, respectively, were comparable with each other but were both significantly greater than the CV of 0.08 corresponding to the HPS lamp. The average fresh weight or dry weight of lettuce grown in the solar chamber with either the Himawari or the OW SICTDS showed no statistical difference from the average fresh weight or dry weight of lettuce grown in the reference chamber with the HPS lamp. The results of this study suggest that an SICTDS could help reduce the electric power demand in a BLSS.

  10. Improvement of functional constipation with kiwifruit intake in a Mediterranean patient population: An open, non-randomized pilot study

    Directory of Open Access Journals (Sweden)

    Oriol Cunillera

    2015-07-01

    Full Text Available Introduction: Kiwifruit consumption has shown to improve functional constipation in healthy elderly population, according to studies in New Zealand and China. The aim of this study was to evaluate the effect of kiwifruit intake on functional constipation in a Mediterranean patient population characterized by its distinctive nutritional habits.Material and Methods: An open, non-controlled and non-randomized longitudinal study was conducted in 46 patients with constipation (Rome III criteria. Patients monitored for five weeks: weeks 1 and 2 no kiwifruit and weeks 3-5 three kiwifruit per day (Green kiwifruit, Actinidia deliciosa var Hayward. Bristol Scale, volume of stools, and ease of defecation was self- reported daily. The evolution of the categorical variables was tested using the Bhapkar test; functional data methodology was used for continuous variables, and Generalized Estimating Equation (GEE models were adjusted.Results: The percentage of patients with ≥3 stools per week increased from 82.61% (95% CI: 69–91.2 at week 1 to 97.78% (95% CI: 87.4–99.9 at week 2 of kiwifruit intake, with 76.09% (95% CI: 61.9–86.2 responding during the first week. The reporting of stable ideal stools increased from 17.39% (95% CI: 8.8–31 at week 2 to 33.33% (95% CI: 21.3–48 at week 5. According to GEE models, the number of depositions increased significantly (p-values<0.001 in 0.398 daily units at week 1 the first week of intake, up to 0.593 daily units at week 5; significant improvements on facility in evacuation and volume of evacuation were found from the firstweek of intake (all p-values<0.001.Conclusions: The intake of three kiwifruits per day significantly improves the quality of evacuation (number of depositions, volume, consistency and ease in a Mediterranean patient population suffering from functional constipation.

  11. Neurotransmitter changes in patients with Parkinson's disease detected by encephalofluctuography technology A non-randomized control study

    Institute of Scientific and Technical Information of China (English)

    Yan Han; Zhenfu Wang; Yang Yang; Xianhong Chen; Hong Sun

    2008-01-01

    BACKGROUND: Encephalofluctuograph Technology (ET) is an advanced and non-traumatic analytical method of brain function. ET can acquire super-slow waves from electroencephalic signals. Studies have shown that these particular spectra can reflect neurochemical processes in the brain. OBJECTIVE: To verify neurotransmitter changes in the brains Parkinson's disease (PD) patients through the use of ET. DESIGN, TIME AND SETTING: A non-randomized concurrent control experiment was performed at the Department of Neurology in Southern Building, General Hospital of Chinese PLA from August to December 2007. PARTICIPANTS: Sixty-one outpatients with PD were selected from the General Hospital of Chinese PLA from August 2007 to December 2007. In addition, 48 healthy subjects were selected as normal controls. METHODS: All patients underwent assessment of the sub scale Ⅱ,Ⅲ, and V of the Unified Parkinson's Disease Rating Scale (UPDRS), in which part Ⅱ was used to inform activity of daily living, part Ⅲ reflected athletic ability, and part Ⅴ was the Hoehn & Yahr grade for symptoms evaluation. Correlation analysis was performed between dopamine levels and UPDRS assessment. Neurotransmitter changes were observed forty-eight prior to and 1.5 hours after medicating with Benserazide. The S1, S2, S4, S5,S7, and S11 spectras respectively reflect gamma-aminobutyric acid (GABA), glutamic acid (Glu), 5-hydroxytryptamine (5-HT), acetylcholine (ACh), norepinephrine, and dopamine. MAIN OUTCOME MEASURES: Neurotransmitter changes in the brains of all subjects, and correlations between dopamine concentrations and UPDRS assessment. Neurotransmitter changes in a subgroup of patients prior to and 1.5 hours after medicating with Benserazide. RESULTS: Concentrations of 5-HT, ACh, and norepinephrine were decreased in the PD group, and GABA was increased. However, there was no significant difference compared with the normal control group (P > 0.05). The level of dopamine in PD group was

  12. Effectiveness of a 'Global Postural Reeducation' program for persistent Low Back Pain: a non-randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Violante Francesco S

    2010-12-01

    Full Text Available Abstract Background The aim of this non-randomized controlled trial was to evaluate the effectiveness of a Global Postural Reeducation (GPR program as compared to a Stabilization Exercise (SE program in subjects with persistent low back pain (LBP at short- and mid-term follow-up (ie. 3 and 6 months. Methods According to inclusion and exclusion criteria, 100 patients with a primary complaint of persistent LBP were enrolled in the study: 50 were allocated to the GPR group and 50 to the SE group. Primary outcome measures were Roland and Morris Disability Questionnaire (RMDQ and Oswestry Disability Index (ODI. Secondary outcome measures were lumbar Visual Analogue Scale (VAS and Fingertip-to-floor test (FFT. Data were collected at baseline and at 3/6 months by health care professionals unaware of the study. An intention to treat approach was used to analyze participants according to the group to which they were originally assigned. Results Of the 100 patients initially included in the study, 78 patients completed the study: 42 in the GPR group and 36 in the SE group. At baseline, the two groups did not differ significantly with respect to gender, age, BMI and outcome measures. Comparing the differences between groups at short- and mid-term follow-up, the GPR group revealed a significant reduction (from baseline in all outcome measures with respect to the SE group. The ordered logistic regression model showed an increased likelihood of definitive improvement (reduction from baseline of at least 30% in RMDQ and VAS scores for the GPR group compared to the SE group (OR 3.9, 95% CI 2.7 to 5.7. Conclusions Our findings suggest that a GPR intervention in subjects with persistent LBP induces a greater improvement on pain and disability as compared to a SE program. These results must be confirmed by further studies with higher methodological standards, including randomization, larger sample size, longer follow-up and subgrouping of the LBP subjects. Trial

  13. A psycho-educational HIV/STI prevention intervention for internally displaced women in Leogane, Haiti: results from a non-randomized cohort pilot study.

    Directory of Open Access Journals (Sweden)

    Carmen H Logie

    Full Text Available BACKGROUND: Little evidence exists regarding efficacious HIV and sexually transmitted infections (STI prevention interventions with internally displaced populations. Internally displaced women are at elevated risk for HIV/STI due to limited access to health services, heightened poverty and social network breakdown. The FASY (Famn an Aksyon Pou Sante' Yo (Women Taking Action For Their Health study examined the effectiveness of a peer health worker (PHW delivered psycho-educational HIV/STI pilot study with internally displaced women in Leogane, Haiti. METHOD: This was a non-randomized cohort pilot study. Participants completed a computer-assisted pre-test programmed on Android tablet PCs followed by an HIV/STI educational video-based session and a 6-week psycho-educational group program of weekly meetings. Participants completed a post-test upon completion of group sessions. The primary outcome was HIV knowledge; our pre-specified index of clinically significant change was an effect size of 0.30. Secondary outcomes included: STI knowledge, condom use, social support, resilient coping, depression and relationship control. We used mixed-effects regression to calculate mean outcome pre-post score change. This study was registered (clinicaltrials.gov, NCT01492829. RESULTS: Between January 1-April 30, 2012 we assigned 200 participants to the study. The majority of participants (n = 176, 88% completed the study and were followed up at 8 weeks, finishing April 30, 2012. Adjusted for socio-demographic characteristics, HIV knowledge (β = 4.81; 95% CI 4.36-5.26, STI knowledge (β = 0.84; 95% CI 0.70-0.99, condom use (AOR = 4.05, 95% CI 1.86-8.83, and depression (β = -0.63, 95% CI -0.88--0.39 scores showed statistically significant change post-intervention (p<0.05. CONCLUSIONS: This pilot study evaluated a PHW psycho-educational HIV/STI prevention intervention among internally displaced women in post-earthquake Haiti. Pilot studies are an important

  14. Effects of an Integrated ‘Fast Track’ Rehabilitation Service for Multi-Trauma Patients: A Non-Randomized Clinical Trial in the Netherlands

    Science.gov (United States)

    Bouman, Ans I. E.; Hemmen, Bea; Evers, Silvia M. A. A.; van de Meent, Henk; Ambergen, Ton; Vos, Pieter E.; Brink, Peter R. G.; Seelen, Henk A. M.

    2017-01-01

    Objectives The effects on health related outcomes of a newly-developed rehabilitation program, called ‘supported Fast Track multi-trauma rehabilitation service’ (Fast Track), were evaluated in comparison with conventional trauma rehabilitation service (Care as Usual). Methods Prospective, multi-center, non-randomized controlled study. Between 2009 and 2012, 132 adult multi-trauma patients were included: 65 Fast Track and 67 Care as Usual patients with an Injury Severity Score ≥16, complex multiple injuries in several extremities or complex pelvic and/or acetabulum fractures. The Fast Track program involved: integrated coordination between trauma surgeon and rehabilitation physician, shorter stay in hospital with faster transfer to a specialized trauma rehabilitation unit, earlier start of multidisciplinary treatment and ‘non-weight bearing’ mobilization. Primary outcomes were functional status (FIM) and quality of life (SF-36) measured through questionnaires at baseline, 3, 6, 9 and 12 months post-trauma. Outcomes were analyzed using a linear mixed-effects regression model. Results The FIM scores significantly increased between 0 and 3 months (p<0.001) for both groups showing that they had improved overall, and continued to improve between 3 and 6 months for Fast Track (p = 0.04) and between 3 and 9 months for Care as Usual (p = 0.03). SF-36 scores significantly improved in both groups between 3 and 6 months (Fast Track, p<0.001; Care as Usual, p = 0.01). At 12 months, SF-36 scores were still below (self-reported) baseline measurements of patient health prior to the accident. However, the FIM and SF-36 scores differed little between the groups at any of the measured time points. Conclusion Both Fast Track and Care as Usual rehabilitation programs were effective in that multi-trauma patients improved their functional status and quality of life. A faster (maximum) recovery in functional status was observed for Fast Track at 6 months compared to 9 months for

  15. Differentiation and Distribution of Marrow Stem Cells in Flex-Flow Environments Demonstrate Support of the Valvular Phenotype.

    Directory of Open Access Journals (Sweden)

    Sasmita Rath

    Full Text Available For treatment of critical heart valve diseases, prosthetic valves perform fairly well in most adults; however, for pediatric patients, there is the added requirement that the replacement valve grows with the child, thus extremely limiting current treatment options. Tissue engineered heart valves (TEHV, such as those derived from autologous bone marrow stem cells (BMSCs, have the potential to recapitulate native valve architecture and accommodate somatic growth. However, a fundamental pre-cursor in promoting directed integration with native tissues rather than random, uncontrolled growth requires an understanding of BMSC mechanobiological responses to valve-relevant mechanical environments. Here, we report on the responses of human BMSC-seeded polymer constructs to the valve-relevant stress states of: (i steady flow alone, (ii cyclic flexure alone, and (iii the combination of cyclic flexure and steady flow (flex-flow. BMSCs were seeded onto a PGA: PLLA polymer scaffold and cultured in static culture for 8 days. Subsequently, the aforementioned mechanical conditions, (groups consisting of steady flow alone-850ml/min, cyclic flexure alone-1 Hz, and flex-flow-850ml/min and 1 Hz were applied for an additional two weeks. We found samples from the flex-flow group exhibited a valve-like distribution of cells that expressed endothelial (preference to the surfaces and myofibroblast (preference to the intermediate region phenotypes. We interpret that this was likely due to the presence of both appreciable fluid-induced shear stress magnitudes and oscillatory shear stresses, which were concomitantly imparted onto the samples. These results indicate that flex-flow mechanical environments support directed in vitro differentiation of BMSCs uniquely towards a heart valve phenotype, as evident by cellular distribution and expression of specific gene markers. A priori guidance of BMSC-derived, engineered tissue growth under flex-flow conditions may serve to

  16. A finite element analysis of two different dental implants: stress distribution in the prosthesis, abutment, implant, and supporting bone.

    Science.gov (United States)

    Quaresma, Sergio E T; Cury, Patricia R; Sendyk, Wilson R; Sendyk, Claudio

    2008-01-01

    This study evaluates the influence of 2 commercially available dental implant systems on stress distribution in the prosthesis, abutment, implant, and supporting alveolar bone under simulated occlusal forces, employing a finite element analysis. The implants and abutments evaluated consisted of a stepped cylinder implant connected to a screw-retained, internal, hexagonal abutment (system 1) and a conical implant connected to a solid, internal, conical abutment (system 2). A porcelain-covered, silver-palladium alloy was used as a crown. In each case, a simulated, 100-N vertical load was applied to the buccal cusp. A finite element model was created based on the physical properties of each component, and the values of the von Mises stresses generated in the prosthesis, abutment, implant, and supporting alveolar bone were calculated. In the prostheses, the maximum von Mises stresses were concentrated at the points of load application in both systems, and they were greater in system 1 (148 N/mm2) than in system 2 (55 N/mm2). Stress was greater on the abutment of system 2 than of system 1 on both the buccal (342 N/mm2 x 294 N/mm2) and lingual (294 N/mm2 x 148 N/ mm2) faces. Stress in the cortical, alveolar bone crest was greater in system 1 than in system 2 (buccal: 99.5 N/mm2 x 55 N/mm2, lingual: 55 N/mm2 x 24.5 N/mm2, respectively). Within the limits of this investigation, the stepped cylinder implant connected to a screw-retained, internal hexagonal abutment produces greater stresses on the alveolar bone and prosthesis and lower stresses on the abutment complex. In contrast, the conical implant connected to a solid, internal, conical abutment furnishes lower stresses on the alveolar bone and prosthesis and greater stresses on the abutment.

  17. Insulin resistance and occurrence and prognosis of ischemic stroke A non-randomized concurrent control and intra-group comparison

    Institute of Scientific and Technical Information of China (English)

    Xiaohong Zhao; Shaojun Jiang; Yue Tan

    2008-01-01

    BACKGROUND: Clinical evidence has demonstrated that insulin resistance might be an independent risk factor for ischemic stroke, which has not been recognized. At present, insulin resistance has been proven to be an independent risk factor for coronary arteriosclerotic heart disease. However, the relationship between the onset and prognosis of ischemic stroke remains unclear. OBJECTIVE: This study was designed to analyze the relationship between insulin resistance and ischemic stroke and the correlation between insulin resistance and stroke risk factor, and to investigate the relationship between insulin resistance and ischemic stroke prognosis as well as whether insulin resistance is an independent prognostic factor. DESIGN: A non-randomized concurrent control experiment. SETTING: Department of Geriatric Disease, Second Affiliated Hospital of Kunming Medical College. PARTICIPANTS: A total of 106 inpatients with ischemic stroke of the cervical internal carotid artery, who had suffered from the disease within the previous 72 hours, were admitted to the Department of Neurology, First Affiliated Hospital of Kunming Medical College from March to December in 2005 and, recruited for the present study. All 106 inpatients corresponded to the diagnostic criteria of ischemic stroke, formulated at the Fourth National Cerebrovascular Disease Conference in 1995, and were confirmed as having had an ischemic stroke by CT/MRI examinations. The patient group consisted of 54 males and 52 females. An additional 50 healthy individuals, who received health examinations simultaneously, were included as controls. Among the control subjects, there were 26 males and 24 females. Informed consent for laboratory measurements was obtained from all subjects; this study was approved by the Hospital Ethics Committee.METHODS: Following admission, all subjects were inquired of age, gender, previous history, blood pressure, body temperature, admission time, and smoking habits. Meanwhile, they were

  18. Charting the effects of TMS with fMRI: Modulation of cortical recruitment within the distributed network supporting semantic control.

    Science.gov (United States)

    Hallam, Glyn P; Whitney, Carin; Hymers, Mark; Gouws, Andre D; Jefferies, Elizabeth

    2016-12-01

    Semantic memory comprises our knowledge of the meanings of words and objects but only some of this knowledge is relevant at any given time. Thus, semantic control processes are needed to focus retrieval on relevant information. Research on the neural basis of semantic control has strongly implicated left inferior frontal gyrus (LIFG) but recent work suggests that a wider network supports semantic control, including left posterior middle temporal gyrus (pMTG), right inferior frontal gyrus (RIFG) and pre-supplementary motor area (pre-SMA). In the current study, we used repetitive transcranial magnetic stimulation (1Hz offline TMS) over LIFG, immediately followed by fMRI, to examine modulation of the semantic network. We compared the effect of stimulation on judgements about strongly-associated words (dog-bone) and weaker associations (dog-beach), since previous studies have found that dominant links can be recovered largely automatically with little engagement of LIFG, while more distant connections require greater control. Even though behavioural performance was maintained in response to TMS, LIFG stimulation increased the effect of semantic control demands in pMTG and pre-SMA, relative to stimulation of a control site (occipital pole). These changes were accompanied by reduced recruitment of both the stimulated region (LIFG) and its right hemisphere homologue (RIFG), particularly for strong associations with low control requirements. Thus repetitive TMS to LIFG modulated the contribution of distributed regions to semantic judgements in two distinct ways.

  19. Decentralized and Real-Time Power Dispatch Control for an Islanded Microgrid Supported by Distributed Power Sources

    Directory of Open Access Journals (Sweden)

    Changsun Ahn

    2013-12-01

    Full Text Available Microgrids can deploy traditional and/or renewable power sources to support remote sites. Utilizing renewable power sources requires more complicated control strategies to achieve acceptable power quality and maintain grid stability. In this research, we assume that the grid stability problem is already solved. As a next step, we focus on how the power can be dispatched from multiple power sources for improved grid efficiency. Isolated microgrids frequently require reconfigurations because of the grid expansion or component failures. Therefore, the control strategies ideally should be implemented in a plug-and-play fashion. Moreover, these strategies ideally require no pre-knowledge of the grid structure, and as little communication with neighboring power sources as possible. The control objective is to minimize a cost function that can be adjusted to reflect the desire to minimize energy cost and/or losses. An algorithm is designed to satisfy a derived necessary condition of function optimality. Such conditions are obtained by formulating Lagrange functions. An equivalent grid model approximates the grid structure which was later confirmed to represent the grid behavior adequately. For decentralized operations, we execute the distributed control sequentially using a simple token communication protocol. The performance of the combined system identification-Lagrange function minimization algorithm is demonstrated through simulations.

  20. Distribution-mode Logistical Support in Modern Warfare%现代战争条件下的配送式后勤保障

    Institute of Scientific and Technical Information of China (English)

    吴兆东; 朱江浩

    2016-01-01

    The distribution-mode logistical support is the product of the warfare in the information era and has become a basic form of the modern logistical practices. In this paper, in connection with the characteristics of military distribution and transportation, we analyzed the logistical support mode of the U.S. army in the war in Iraq and then proposed some thoughts on building the distribution-mode logistical support system by the Chinese army.%配送式后勤保障是信息化条件下的战争产物,已成为现代后勤保障的基本形式.结合军事物流配送的特点,分析了伊拉克战争中美军这种后勤保障模式的特点,提出关于我军配送式后勤保障建设的思考.

  1. Distributed Knight

    DEFF Research Database (Denmark)

    Hansen, Klaus Marius; Damm, Christian Heide

    2005-01-01

    An extension of Knight (2005) that support distributed synchronous collaboration implemented using type-based publish/subscribe......An extension of Knight (2005) that support distributed synchronous collaboration implemented using type-based publish/subscribe...

  2. The role of prosthetic abutment material on the stress distribution in a maxillary single implant-supported fixed prosthesis

    Energy Technology Data Exchange (ETDEWEB)

    Peixoto, Hugo Eduardo, E-mail: hugo.e.peixoto@hotmail.com [Implantology Team, Latin American Institute of Research and Education in Dentistry, Curitiba, Paraná (Brazil); Bordin, Dimorvan, E-mail: dimorvan_bordin@hotmail.com [Department of Prosthodontics and Periodontology, Piracicaba Dental School, State University of Campinas, Limeira avenue, 901-Vila Rezende, Piracicaba, SP 13414-903 (Brazil); Del Bel Cury, Altair A., E-mail: altcury@fop.unicamp.br [Department of Prosthodontics and Periodontology, Piracicaba Dental School, State University of Campinas, Limeira avenue, 901-Vila Rezende, Piracicaba, SP 13414-903 (Brazil); Silva, Wander José da, E-mail: wanderjose@fop.unicamp.br [Department of Prosthodontics and Periodontology, Piracicaba Dental School, State University of Campinas, Limeira avenue, 901-Vila Rezende, Piracicaba, SP 13414-903 (Brazil); Faot, Fernanda, E-mail: fernanda.faot@gmail.com [Department of Restorative Dentistry, School of Dentistry, Federal University of Pelotas, Gonçalves Chaves, 457, 2nd floor, Pelotas, Rio Grande do Sul 96015-560 (Brazil)

    2016-08-01

    Purpose: Evaluate the influence of abutment's material and geometry on stress distribution in a single implant-supported prosthesis. Materials and Methods: Three-dimensional models were made based on tomographic slices of the upper middle incisor area, in which a morse taper implant was positioned and a titanium (Ti) or zirconia (ZrN) universal abutments was installed. The commercially available geometry of titanium (T) and zirconia (Z) abutments were used to draw two models, TM1 and ZM1 respectively, which served as control groups. These models were compared with 2 experimental groups were the mechanical properties of Z were applied to the titanium abutment (TM2) and vice versa for the zirconia abutment (ZM2). Subsequently, loading was simulated in two steps, starting with a preload phase, calculated with the respective friction coefficients of each materials, followed by a combined preload and chewing force. The maximum von Mises stress was described. Data were analyzed by two-way ANOVA that considered material composition, geometry and loading (p < 0.05). Results: Titanium and zirconia abutments showed similar von Mises stresses in the mechanical part of the four models. The area with the highest concentration of stress was the screw thread, following by the screw body. The highest stress levels occurred in screw thread was observed during the preloading phase in the ZM1 model (931 MPa); and during the combined loading in the TM1 model (965 MPa). Statistically significant differences were observed for loading, the material × loading interaction, and the loading × geometry interaction (p < 0.05). Preloading contributed for 77.89% of the stress (p < 0.05). There were no statistically significant differences to the other factors (p > 0.05). Conclusion: The screw was the piece most intensely affected, mainly through the preload force, independent of the abutment's material. - Highlights: • The abutment's screw was the most impaired piece of the

  3. A Framework System for Intelligent Support in Open Distributed Learning Environments--A Look Back from 16 Years Later

    Science.gov (United States)

    Hoppe, H. Ulrich

    2016-01-01

    The 1998 paper by Martin Mühlenbrock, Frank Tewissen, and myself introduced a multi-agent architecture and a component engineering approach for building open distributed learning environments to support group learning in different types of classroom settings. It took up prior work on "multiple student modeling" as a method to configure…

  4. Impact of the β-Lactam Resistance Modifier (−)-Epicatechin Gallate on the Non-Random Distribution of Phospholipids across the Cytoplasmic Membrane of Staphylococcus aureus

    OpenAIRE

    Rosado, H.; Turner, R.D.; Foster, S. J.; Taylor, P. W.

    2015-01-01

    The polyphenol (−)-epicatechin gallate (ECg) inserts into the cytoplasmic membrane (CM) of methicillin-resistant Staphylococcus aureus (MRSA) and reversibly abrogates resistance to β-lactam antibiotics. ECg elicits an increase in MRSA cell size and induces thickened cell walls. As ECg partially delocalizes penicillin-binding protein PBP2 from the septal division site, reduces PBP2 and PBP2a complexation and induces CM remodelling, we examined the impact of ECg membrane intercalation on phosph...

  5. Study on the distribution of active centers in novel low Ti-loading MgCl2-supported Ziegler-Natta catalyst

    Institute of Scientific and Technical Information of China (English)

    王剑峰; 王立; 赵振荣; 王文钦; 陈涛

    2004-01-01

    Novel MgCl2-supported Ziegler-Natta (Z-N) catalysts prepared using a new one-pot ball milling method can effectively control the amounts of Ti-loading in the catalysts. Complex GPC data on polypropylene synthesized by these novel catalysts were analyzed using the method of fitting the molecular weight distribution (MWD) curves with a multiple Flory-Schulz function. It was found that multiple active centers exist in these novel catalysts. Detailed study of the effects of the Ti-loadings in the catalysts on the distribution of the active centers showed that the Ti-loadings in the novel MgCl2-supported Z-N catalysts might affect the proportion of each type of active centers; and might be the main factor responsible for the effect of the Ti-loadings on the microstructure, the molecular weight and molecular weight distribution width of the resultant polymer, the catalytic activity and polymerization kinetics.

  6. Comparative cost analysis of insecticide-treated net delivery strategies: sales supported by social marketing and free distribution through antenatal care.

    Science.gov (United States)

    De Allegri, Manuela; Marschall, Paul; Flessa, Steffen; Tiendrebéogo, Justin; Kouyaté, Bocar; Jahn, Albrecht; Müller, Olaf

    2010-01-01

    Insecticide-treated nets (ITNs) are effective in substantially reducing malaria transmission. Still, ITN coverage in sub-Saharan Africa (SSA) remains extremely low. Policy makers are concerned with identifying the most suitable delivery mechanism to achieve rapid yet sustainable increases in ITN coverage. Little is known, however, on the comparative costs of alternative ITN distribution strategies. This paper aimed to fill this gap in knowledge by developing such a comparative cost analysis, looking at the cost per ITN distributed for two alternative interventions: subsidized sales supported by social marketing and free distribution to pregnant women through antenatal care (ANC). The study was conducted in rural Burkina Faso, where the two interventions were carried out alongside one another in 2006/07. Cost information was collected prospectively to derive both a financial analysis adopting a provider's perspective and an economic analysis adopting a societal perspective. The average financial cost per ITN distributed was US$8.08 and US$7.21 for sales supported by social marketing and free distribution through ANC, respectively. The average economic cost per ITN distributed was US$4.81 for both interventions. Contrary to common belief, costs did not differ substantially between the two interventions. Due to the district's ability to rely fully on the use of existing resources, financial costs associated with free ITN distribution through ANC were in fact even lower than those associated with the social marketing campaign. This represents an encouraging finding for SSA governments and points to the possibility to invest in programmes to favour free ITN distribution through existing health facilities. Given restricted budgets, however, free distribution programmes are unlikely to be feasible.

  7. Silica-supported (nBuCp)2ZrCl2: Effect of catalyst active center distribution on ethylene-1-hexene copolymerization

    KAUST Repository

    Atiqullah, Muhammad

    2013-08-12

    Metallocenes are a modern innovation in polyolefin catalysis research. Therefore, two supported metallocene catalysts-silica/MAO/(nBuCp)2ZrCl2 (Catalyst 1) and silica/nBuSnCl3/MAO/(nBuCp)2ZrCl2 (Catalyst 2), where MAO is methylaluminoxane-were synthesized, and subsequently used to prepare, without separate feeding of MAO, ethylene-1-hexene Copolymer 1 and Copolymer 2, respectively. Fouling-free copolymerization, catalyst kinetic stability and production of free-flowing polymer particles (replicating the catalyst particle size distribution) confirmed the occurrence of heterogeneous catalysis. The catalyst active center distribution was modeled by deconvoluting the measured molecular weight distribution and copolymer composition distribution. Five different active center types were predicted for each catalyst, which was corroborated by successive self-nucleation and annealing experiments, as well as by an extended X-ray absorption fine structure spectroscopy report published in the literature. Hence, metallocenes impregnated particularly on an MAO-pretreated support may be rightly envisioned to comprise an ensemble of isolated single sites that have varying coordination environments. This study shows how the active center distribution and the design of supported MAO anions affect copolymerization activity, polymerization mechanism and the resulting polymer microstructures. Catalyst 2 showed less copolymerization activity than Catalyst 1. Strong chain transfer and positive co-monomer effect-both by 1-hexene-were common. Each copolymer demonstrated vinyl, vinylidene and trans-vinylene end groups, and compositional heterogeneity. All these findings were explained, as appropriate, considering the modeled active center distribution, MAO cage structure repeat units, proposed catalyst surface chemistry, segregation effects and the literature that concerns and supports this study. While doing so, new insights were obtained. Additionally, future research, along the direction

  8. Non-random pre-transcriptional evolution in HIV-1: a refutation of the foundational conditions for neutral evolution

    Directory of Open Access Journals (Sweden)

    Carlos Y Valenzuela

    2009-01-01

    Full Text Available The complete base sequence of HIV-1 virus and GP120 ENV gene were analyzed to establish their distance to the expected neutral random sequence. An especial methodology was devised to achieve this aim. Analyses included: a proportion of dinucleotides (signatures; b homogeneity in the distribution of dinucleotides and bases (isochores by dividing both segments in ten and three sub-segments, respectively; c probability of runs of bases and No-bases according to the Bose-Einstein distribution. The analyses showed a huge deviation from the random distribution expected from neutral evolution and neutral-neighbor influence of nucleotide sites. The most significant result is the tremendous lack of CG dinucleotides (p < 10-50, a selective trait of eukaryote and not of single stranded RNA virus genomes. Results not only refute neutral evolution and neutral neighbor influence, but also strongly indicate that any base at any nucleotide site correlates with all the viral genome or sub-segments. These results suggest that evolution of HIV-1 is pan-selective rather than neutral or nearly neutral.

  9. Decision Support Tool: Modeling the Distribution and Abundance of Birds on the Alaska Peninsula: A Synthesis of Recent Survey Data

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This progress report for the Modeling the Distribution and Abundance of Birds on the Alaska Peninsula project covers activities during FY2015. The goal of this...

  10. A non-randomized [corrected] controlled trial of the active music engagement (AME) intervention on children with cancer.

    Science.gov (United States)

    Robb, Sheri L; Clair, Alicia A; Watanabe, Masayo; Monahan, Patrick O; Azzouz, Faouzi; Stouffer, Janice W; Ebberts, Allison; Darsie, Emily; Whitmer, Courtney; Walker, Joey; Nelson, Kirsten; Hanson-Abromeit, Deanna; Lane, Deforia; Hannan, Ann

    2008-07-01

    Coping theorists argue that environmental factors affect how children perceive and respond to stressful events such as cancer. However, few studies have investigated how particular interventions can change coping behaviors. The active music engagement (AME) intervention was designed to counter stressful qualities of the in-patient hospital environment by introducing three forms of environmental support. The purpose of this multi-site randomized controlled trial was to determine the efficacy of the AME intervention on three coping-related behaviors (i.e. positive facial affect, active engagement, and initiation). Eighty-three participants, ages 4-7, were randomly assigned to one of three conditions: AME (n = 27), music listening (ML; n = 28), or audio storybooks (ASB; n = 28). Conditions were videotaped to facilitate behavioral data collection using time-sampling procedures. After adjusting for baseline differences, repeated measure analyses indicated that AME participants had a significantly higher frequency of coping-related behaviors compared with ML or ASB. Positive facial affect and active engagement were significantly higher during AME compared with ML and ASB (p<0.0001). Initiation was significantly higher during AME than ASB (p<0.05). This study supports the use of the AME intervention to encourage coping-related behaviors in hospitalized children aged 4-7 receiving cancer treatment. (c) 2007 John Wiley & Sons, Ltd.

  11. Environmental Transmission Electron Microscopy Study of the Origins of Anomalous Particle Size Distributions in Supported Metal Catalysts

    DEFF Research Database (Denmark)

    Benavidez, Angelica D.; Kovarik, Libor; Genc, Arda

    2012-01-01

    at temperatures up to 600 °C. Individual NPs of Pd were tracked to determine the operative sintering mechanisms. We found anomalous growth of NPs occurred during the early stages of catalyst sintering wherein some particles started to grow significantly larger than the mean, resulting in a broadening...... explain PSDs in heterogeneous catalysts which often show particles that are significantly larger than the mean, resulting in a long tail to the right. It has been suggested previously that particle migration and coalescence could be the likely cause for such broad size distributions. We did not detect any...... of the particle size distribution (PSD). The abundance of the larger particles did not fit the log-normal distribution. We can rule out sample nonuniformity as a cause for the growth of these large particles, since images were recorded prior to heat treatments. The anomalous growth of these particles may help...

  12. Cyclooctane metathesis catalyzed by silica-supported tungsten pentamethyl [(ΞSiO)W(Me)5]: Distribution of macrocyclic alkanes

    KAUST Repository

    Riache, Nassima

    2014-10-03

    Metathesis of cyclic alkanes catalyzed by the new surface complex [(ΞSiO)W(Me)5] affords a wide distribution of cyclic and macrocyclic alkanes. The major products with the formula CnH2n are the result of either a ring contraction or ring expansion of cyclooctane leading to lower unsubstituted cyclic alkanes (5≤n≤7) and to an unprecedented distribution of unsubstituted macrocyclic alkanes (12≤n≤40), respectively, identified by GC/MS and by NMR spectroscopies.

  13. Inbreeding and purging at the genomic Level: the Chillingham cattle reveal extensive, non-random SNP heterozygosity.

    Science.gov (United States)

    Williams, J L; Hall, S J G; Del Corvo, M; Ballingall, K T; Colli, L; Ajmone Marsan, P; Biscarini, F

    2016-02-01

    Local breeds of livestock are of conservation significance as components of global biodiversity and as reservoirs of genetic variation relevant to the future sustainability of agriculture. One such rare historic breed, the Chillingham cattle of northern England, has a 350-year history of isolation and inbreeding yet shows no diminution of viability or fertility. The Chillingham cattle have not been subjected to selective breeding. It has been suggested previously that the herd has minimal genetic variation. In this study, high-density SNP genotyping with the 777K SNP chip showed that 9.1% of loci on the chip are polymorphic in the herd, compared with 62-90% seen in commercial cattle breeds. Instead of being homogeneously distributed along the genome, these loci are clustered at specific chromosomal locations. A high proportion of the Chillingham individuals examined were heterozygous at many of these polymorphic loci, suggesting that some loci are under balancing selection. Some of these frequently heterozygous loci have been implicated as sites of recessive lethal mutations in cattle. Linkage disequilibrium equal or close to 100% was found to span up to 1350 kb, and LD was above r(2) = 0.25 up to more than 5000 kb. This strong LD is consistent with the lack of polymorphic loci in the herd. The heterozygous regions in the Chillingham cattle may be the locations of genes relevant to fitness or survival, which may help elucidate the biology of local adaptation in traditional breeds and facilitate selection for such traits in commercial cattle.

  14. 大型多支承变刚度回转窑支承载荷分配问题%Research on supporting load distribution of large-scale rotary kiln with multi-support and variable-stiffness

    Institute of Scientific and Technical Information of China (English)

    李学军; 蒋玲莉; 刘德顺

    2005-01-01

    回转窑是冶金、水泥、耐火材料生产中的核心设备,是一种重载、大扭矩、多支点、静不定运行系统,由于其载荷和刚度分布复杂、各支承存在偏移,作用在它托轮上的支承载荷分配严重不均.本文针对回转窑载荷和刚度分布的特点,建立支承载荷求解的力学模型和线性方程组,导出支承载荷分配与支承偏差的关系式;用该方法对现场回转窑进行计算,得出该窑支承载荷分配的线性公式和一些分析结论,为生产中回转窑的状态分析、优化调控提供依据.%Kiln are the key equipment in the production of metallurgy, cement and material of fire-fast. It is the statically indeterminate system with over load, large torque and multi-support. Because of the complexity of load and stiffness distribution of the rotary kiln, the deflection of supporting center, the supporting load distribution will become seriously non-uniform. To the characters of load and stiffness distribution of the rotary kiln, the mechanical model and equation group are established, which are used to solve the variable-stiffness beam upon complex load for kiln. The relation between the supporting load distribution and deflection is derived. Accordingly, the liner formulas for calculating the support force of the support wheels fixing on the rotate kiln are obtained from the practical calculation of rotary kilns, and some useful analysis conclusions are obtained. This will provide helpful guide to condition analysis and optimization control of rotary kiln.

  15. A Game-Based Approach to Support Social Presence and Awareness in Distributed Project-Based Learning

    Science.gov (United States)

    Marklund, Björn Berg; Backlund, Per; Dahlin, Carl-Johan; Engström, Henrik; Wilhelmsson, Ulf

    2014-01-01

    An important factor for success in project-based learning (PBL) is that the involved project groups establish an atmosphere of social interaction in their working environment. In PBL-scenarios situated in distributed environments, most of a group's work-processes are mediated through the use of production-focused tools that are unconcerned with…

  16. Phase-wise enhanced voltage support from electric vehicles in a Danish low-voltage distribution grid

    DEFF Research Database (Denmark)

    Knezovic, Katarina; Marinelli, Mattia

    2016-01-01

    High deployment of electric vehicles (EVs) imposes great challenges for the distribution grids, especially in unbalanced systems with notable voltage variations which detrimentally affect security of supply. On the other hand, with development of Vehicle-to-Grid technology, EVs may be able...

  17. Optimizing Military Logistics Distribution Transport Support%优化军事物流配送运输保障

    Institute of Scientific and Technical Information of China (English)

    陈兵; 陈晨

    2012-01-01

    For the war under the condition of information, it not only is a contest in soldier and weapons, but also is the test of transport support capacity. Only transport support capacity is good, the troop has strong fighting capacity, and wins in the battle. Military logistics transportation is an important way to support army daily training and life, and is the key of war.%信息化条件下的战争,不仅是对人和武器最佳组合的较量,更是对运输保障能力的考验.运输保障跟得上,部队才能有战斗力,才能打得赢.军事物流配送运输是保障军队平时训练、生活等军事活动的重要方式,更是军队战时的大动脉.

  18. Optimization of supporting points distribution for single folding solar panels%单折太阳翼支承点分布优化分析

    Institute of Scientific and Technical Information of China (English)

    李郑发; 曹登庆; 张迎春

    2015-01-01

    支承点的分布对折叠太阳翼动力学特性有显著影响。为了研究压紧点分布对折叠太阳翼固有频率的影响,以典型的单折点支承太阳翼为研究对象,根据能量守恒原理和 Rayleigh-Ritz 理论推导出点支承单折太阳翼的振动方程和频率方程。研究了四点对称支承太阳翼结构系统的固有动力学特性,并以基频最大为优化目标对其支承点的分布进行优化分析。通过算例分析表明其理论计算结果与有限元分析结果具有较好的一致性。研究结果对太阳翼支承点分布的初步设计提供了理论分析依据。%The distribution of supporting points has a significant impact on dynamic characteristics of a folding solar panel.In order to study the effect of supporting points distribution on the fundamental frequency of folding solar panel,a typical single folding solar panel supported at four points was taken as the investigation object.Based on the energy conservation principle and Rayleigh-Ritz theory,a vibration equation and a frequency equation were established for analyzing the free vibration of folding solar panel with points support.The vibration characteristics of the folding solar panel symmetrically supported at four points were solved,and aiming at achieving the maximum fundamental frequency, the optimization of support points distribution was also discussed.The examples show the theoretical calculation results have good consistency with the results of the finite element analysis.The research results could provide a theoretical basis for the preliminary design of supporting points distribution for single folding solar panels.

  19. Hybrid evaluating method for support capability of armament distribution%装备调配保障能力评估混合算法

    Institute of Scientific and Technical Information of China (English)

    陈军生; 周文明

    2011-01-01

    Main influencing factors of equipment distribution and support are analyzed. The characteristics and laws of military operation of armament, ammunition and equipment maintenance material are studied. The support capability of equipment distribution and support is evaluated and predicted by using the method integrating queuing theory, and fuzzy comprehensive evaluation with index method. The relationship among factors is embodied better by the index method. A simulation example of evaluation is presented. The validity and practicability of the comprehensive method is verified, and the proposed method is suitable for the command, decision making and system optimum design of equipment distribution.%分析了装备调配保障的主要影响因素,研究了武器装备、弹药和器材等调配保障的特点和规律,提出了运用指数法、排队网络和模糊综合评判相结合的方法,预测和评估装备调配保障能力,其中指数法能够充分体现各要素之间的关联性.给出了仿真评估实例,验证了方法的实用性,为装备保障指挥决策和系统优化设计提供了理论依据和技术支持.

  20. LOGDIS - a system of support to decision in logistic of petroleum products distribution; LOGDIS - Sistema de apoio a decisao na logistica de distribuicao de derivados de petroleo

    Energy Technology Data Exchange (ETDEWEB)

    Soares, Rogerio M.F.; Limoeiro, Claudio D.P. [PETROBRAS, Rio de Janeiro, RJ (Brazil); Zerbini, Jose E.; Blanco, Jose F. [PETROBRAS Distribuidora, Rio de Janeiro, RJ (Brazil)

    2000-07-01

    The deregulation of the oil product distribution segment in Brazil is inducing higher competition and causing reduction of profit margins for all players in the industry. Until the beginning of the 90's, each of the most important products had the same price all over the country, with freight cost differences being integrally paid by the Brazilian Government. In the context of higher competition the minimization of distribution costs turns to be very important for the survival of players in the marketing and distribution sector. In order to achieve this goal, PETROBRAS Distribuidora (BR) has been using, since 1999, a decision support system known as LogDis that incorporates optimization algorithms and geographic information system, helping the supply planners to work in a better and more effective basis. This paper intends to describe and present this system. (author)

  1. The Self-Made Puzzle: Integrating Self-Assembly and Pattern Formation Under Non-Random Genetic Regulation

    Science.gov (United States)

    Doursat, René

    On the one hand, research in self-assembling systems, whether natural or artificial, has traditionally focused on pre-existing components endowed with fixed shapes. Biological development, by contrast, dynamically creates new cells that acquire selective adhesion properties through differentiation induced by their neighborhood. On the other hand, pattern formation phenomena are generally construed as orderly states of activity on top of a continuous 2-D or 3-D substrate. Yet, again, the spontaneous patterning of an organism into domains of gene expression arises within a multicellular medium in perpetual expansion and reshaping. Finally, both phenomena are often thought in terms of stochastic events, whether mixed components that randomly collide in self-assembly, or spots and stripes that occur unpredictably from instabilities in pattern formation. Here too, these notions need significant revision if they are to be extended and applied to embryogenesis. Cells are not randomly mixed but pre-positioned where cell division occurs. Genetic identity domains are not randomly distributed but highly regulated in number and position. In this work, I present a computational model of program-mable and reproducible artificial morphogenesis that integrates self-assembly and pattern formation under the control of a nonrandom gene regulatory network. The specialized properties of cells (division, adhesion, migration) are determined by the gene expression domains to which they belong, while at the same time these domains further expand and segment into subdomains due to the self-assembly of specialized cells. Through this model, I also promote a new discipline, embryomorphic engineering to solve the paradox of "meta-designing" decentralized, autonomous systems.

  2. 45 CFR 302.52 - Distribution of support collected in Title IV-E foster care maintenance cases.

    Science.gov (United States)

    2010-10-01

    ... interests of the child including: (i) Setting aside amounts for the child's future needs; or (ii) Making all... of children for whom the State is making foster care maintenance payments under the title IV-E State... support obligation for future months, the amount shall be applied to those future months. However,...

  3. A Web-based multi-database system supporting distributed collaborative management and sharing of microarray experiment information.

    Science.gov (United States)

    Burgarella, Sarah; Cattaneo, Dario; Masseroli, Marco

    2006-01-01

    We developed MicroGen, a multi-database Web based system for managing all the information characterizing spotted microarray experiments. It supports information gathering and storing according to the Minimum Information About Microarray Experiments (MIAME) standard. It also allows easy sharing of information and data among all multidisciplinary actors involved in spotted microarray experiments.

  4. Control and impact of the nanoscale distribution of supported cobalt particles used in fischer-tropsch catalysis

    NARCIS (Netherlands)

    Munnik, Peter; De Jongh, Petra E.; De Jong, Krijn P.

    2014-01-01

    The proximity of nanoparticles may affect the performance, in particular the stability, of supported metal catalysts. Short interparticle distances often arise during catalyst preparation by formation of aggregates. The cause of aggregation of cobalt nanoparticles during the synthesis of highly load

  5. Supporting Security against SYN Flooding Attack in Distributed DoS Via Measuring IPFIX-Based Traffic

    Science.gov (United States)

    Alipour, H.; Kia, M. Kashefi; Esmaeili, M.

    Distributed denial-of-service attacks on public servers after 2000 have become a serious problem. In the distributed denial-of-service (DDoS) attacks often seen recently, multiple distributed nodes concurrently attack a single server. To assure that network services will not be interrupted, faster and more effective defense mechanisms is needed to protect against malicious traffic, especially SYN floods. One problem in detecting SYN flood traffic is that server nodes or firewalls cannot distinguish the SYN packets of normal TCP connections from those of a SYN flood attack. Our method, FDFIX, relies on the use of monitoring and measurement techniques to evaluate the impact of DoS attacks. It uses flow based measurements. Capturing flow information is very important for detecting DoS and also other kinds of attacks. Flow monitoring allows detecting suspicious traffics and in the next step can analyze attacking flows and the results can be used for defense methods. Our method provides required information for many mechanisms that use traffic measurement as their input.

  6. Decentralized and Real-Time Power Dispatch Control for an Islanded Microgrid Supported by Distributed Power Sources

    OpenAIRE

    Changsun Ahn; Huei Peng

    2013-01-01

    Microgrids can deploy traditional and/or renewable power sources to support remote sites. Utilizing renewable power sources requires more complicated control strategies to achieve acceptable power quality and maintain grid stability. In this research, we assume that the grid stability problem is already solved. As a next step, we focus on how the power can be dispatched from multiple power sources for improved grid efficiency. Isolated microgrids frequently require reconfigurations because of...

  7. Effect of Occlusal Scheme on the Pressure Distribution of Complete Denture Supporting Tissues: An In Vitro Study

    Science.gov (United States)

    Madalli, Poornima; Murali, C R; Subhas, Sambit; Garg, Surbhi; Shahi, Prinka; Parasher, Pragati

    2015-01-01

    Background: The complete denture teeth arrangement that gives maximum denture stability, comfort, esthetics, and function have been studied since several years. Many occlusal schemes have been advised in which the lingualized occlusion, balanced occlusion, and monoplane occlusion are advocated most popularly. The purpose of this study was to compare the pressure values on the supporting tissue using three diff erent posterior occlusal schemes: Balanced occlusion, lingualized occlusion, and monoplane occlusion in simulated dentures Materials and Methods: The simulators used in this study, composed of the maxillary, and mandibular clear heat cure acrylic resin edentulous models. Pressures on the supporting structure under the complete denture were measured using eight strain gauges placed on the model surface on the buccal and lingual slopes of the ridges on the molar and pre-molar region. Pressure on the supporting structure was measured and signals from the sensors were amplifi ed and recorded by the multi-channel electronic strain indicator. Results: The mean pressure which was obtained at each measurement point was compared by one-way ANOVA test. Conclusion: Overall monoplane occlusion had lesser pressure values compared to completely balanced and lingualized occlusal scheme. Lingualized occlusal scheme was found to transfer stresses from working side to non-working side to stabilize the mandibular denture. PMID:26668486

  8. Final Technical Report for Contract No. DE-EE0006332, "Integrated Simulation Development and Decision Support Tool-Set for Utility Market and Distributed Solar Power Generation"

    Energy Technology Data Exchange (ETDEWEB)

    Cormier, Dallas [San Diego Gas & Electric, CA (United States); Edra, Sherwin [San Diego Gas & Electric, CA (United States); Espinoza, Michael [San Diego Gas & Electric, CA (United States); Daye, Tony [Green Power Labs, San Diego, CA (United States); Kostylev, Vladimir [Green Power Labs, San Diego, CA (United States); Pavlovski, Alexandre [Green Power Labs, San Diego, CA (United States); Jelen, Deborah [Electricore, Inc., Valencia, CA (United States)

    2014-12-29

    This project will enable utilities to develop long-term strategic plans that integrate high levels of renewable energy generation, and to better plan power system operations under high renewable penetration. The program developed forecast data streams for decision support and effective integration of centralized and distributed solar power generation in utility operations. This toolset focused on real time simulation of distributed power generation within utility grids with the emphasis on potential applications in day ahead (market) and real time (reliability) utility operations. The project team developed and demonstrated methodologies for quantifying the impact of distributed solar generation on core utility operations, identified protocols for internal data communication requirements, and worked with utility personnel to adapt the new distributed generation (DG) forecasts seamlessly within existing Load and Generation procedures through a sophisticated DMS. This project supported the objectives of the SunShot Initiative and SUNRISE by enabling core utility operations to enhance their simulation capability to analyze and prepare for the impacts of high penetrations of solar on the power grid. The impact of high penetration solar PV on utility operations is not only limited to control centers, but across many core operations. Benefits of an enhanced DMS using state-of-the-art solar forecast data were demonstrated within this project and have had an immediate direct operational cost savings for Energy Marketing for Day Ahead generation commitments, Real Time Operations, Load Forecasting (at an aggregate system level for Day Ahead), Demand Response, Long term Planning (asset management), Distribution Operations, and core ancillary services as required for balancing and reliability. This provided power system operators with the necessary tools and processes to operate the grid in a reliable manner under high renewable penetration.

  9. Distribution automation and control support; Analysis and interpretation of DAC working group results for use in project planning

    Science.gov (United States)

    Klock, P.; Evans, D.

    1979-01-01

    The Executive Summary and Proceedings of the Working Group Meeting was analyzed to identify specific projects appropriate for Distribution Automation and Control DAC RD&D. Specific projects that should be undertaken in the DAC RD&D program were recommended. The projects are presented under broad categories of work selected based on ESC's interpretation of the results of the Working Group Meeting. Some of the projects are noted as utility industry projects. The ESC recommendations regarding program management are presented. Utility versus Government management responsibilities are noted.

  10. Maui Smart Grid Demonstration Project Managing Distribution System Resources for Improved Service Quality and Reliability, Transmission Congestion Relief, and Grid Support Functions

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-09-30

    The Maui Smart Grid Project (MSGP) is under the leadership of the Hawaii Natural Energy Institute (HNEI) of the University of Hawaii at Manoa. The project team includes Maui Electric Company, Ltd. (MECO), Hawaiian Electric Company, Inc. (HECO), Sentech (a division of SRA International, Inc.), Silver Spring Networks (SSN), Alstom Grid, Maui Economic Development Board (MEDB), University of Hawaii-Maui College (UHMC), and the County of Maui. MSGP was supported by the U.S. Department of Energy (DOE) under Cooperative Agreement Number DE-FC26-08NT02871, with approximately 50% co-funding supplied by MECO. The project was designed to develop and demonstrate an integrated monitoring, communications, database, applications, and decision support solution that aggregates renewable energy (RE), other distributed generation (DG), energy storage, and demand response technologies in a distribution system to achieve both distribution and transmission-level benefits. The application of these new technologies and procedures will increase MECO’s visibility into system conditions, with the expected benefits of enabling more renewable energy resources to be integrated into the grid, improving service quality, increasing overall reliability of the power system, and ultimately reducing costs to both MECO and its customers.

  11. Effect of using polyimide capillaries during thermal experiments on the particle size distribution of supported Pt nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Gámez-Mendoza, Liliana; Resto, Oscar; Martínez-Iñesta, María

    2015-09-20

    Kapton HN-type polyimide capillaries are commonly used as sample holders for transmission X-ray experiments at temperatures below 673 K because of their thermal stability, high X-ray transmittance and low cost. Using high-angle annular dark field scanning high-resolution transmission electron microscopy and thermogravimetric analysis, this work shows that using polyimide capillaries leads to the overgrowth of supported Pt nanoparticles during reduction at temperatures below the glass transition temperature (Tg= 658 K) owing to an outgassing of water from the polyimide. Quartz capillaries were also studied and this overgrowth was not observed.

  12. Uniform distribution of three Candida albicans microsatellite markers in two French ICU populations supports a lack of nosocomial cross-contamination

    Directory of Open Access Journals (Sweden)

    Costa Jean-Marc

    2006-11-01

    Full Text Available Abstract Background The nosocomial acquisition of Candida albicans is a growing concern in intensive care units (ICUs and understanding the route of contamination is relevant for infection control guidelines. Methods To analyze whether there is a specific ecology for any given hospital, we genotyped C. albicans isolates of the ICU of Versailles hospital (Hospital A and compared the results with those previously obtained in another ICU in Henri Mondor hospital (Hospital B using three polymorphic microsatellite markers (PMM. Results Among 36 patients with at least one positive culture for C. albicans, 26 had a specific multilocus genotype, two shared a common multilocus genotype, and 8 had the most common multilocus genotype found in the general population. The time interval between periods of hospitalization between patients with common genotypes differed by 13 to 78 days, thus supporting a lack of direct contamination. To confirm this hypothesis, the multilocus genotypic distributions of the three PMM were compared between the two hospitals. No statistically significant difference was observed. Multiple correspondences analysis did not indicate the association of a multilocus genotypic distribution with any given hospital. Conclusion The present epidemiological study supports the conclusions that each patient harbours his/her own isolate, and that nosocomial transmission is not common in any given ICU. This study also supports the usefulness and practicability of PMM for studying the epidemiology of C. albicans.

  13. Microbial distribution in the Environmental Control and Life Support System water recovery test conducted at NASA, MSFC

    Science.gov (United States)

    Gauthier, J. J.; Roman, M. C.; Kilgore, B. A.; Huff, T. L.; Obenhuber, D. C.; Terrell, D. W.; Wilson, M. E.; Jackson, N. E.

    1991-01-01

    NASA/MSFC is developing a physical/chemical treatment system to reclaim wastewater for reuse on Space Station Freedom (SSF). Integrated testing of hygiene and potable water subsystems assessed the capability to reclaim water to SSF specifications. The test was conducted from May through July 1990 with a total of 47 days of system test operation. Water samples were analyzed using standard cultural methods employing membrane filtration and spread plate techniques and epifluorescence microscopy. Fatty acid methyl ester and biochemical profiles were used for microbial identification. Analysis of waste and product water produced by the subsystems demonstrated the effective reduction of viable microbial populations greater than 8.0E + 06 colony forming units (CFU) per 100 mL to an average of 5 CFU/100 mL prior to distribution into storage tanks.

  14. Microbial distribution in the Environmental Control and Life Support System water recovery test conducted at NASA, MSFC

    Science.gov (United States)

    Gauthier, J. J.; Roman, M. C.; Kilgore, B. A.; Huff, T. L.; Obenhuber, D. C.; Terrell, D. W.; Wilson, M. E.; Jackson, N. E.

    1991-01-01

    NASA/MSFC is developing a physical/chemical treatment system to reclaim wastewater for reuse on Space Station Freedom (SSF). Integrated testing of hygiene and potable water subsystems assessed the capability to reclaim water to SSF specifications. The test was conducted from May through July 1990 with a total of 47 days of system test operation. Water samples were analyzed using standard cultural methods employing membrane filtration and spread plate techniques and epifluorescence microscopy. Fatty acid methyl ester and biochemical profiles were used for microbial identification. Analysis of waste and product water produced by the subsystems demonstrated the effective reduction of viable microbial populations greater than 8.0E + 06 colony forming units (CFU) per 100 mL to an average of 5 CFU/100 mL prior to distribution into storage tanks.

  15. Effect of different types of prosthetic platforms on stress-distribution in dental implant-supported prostheses.

    Science.gov (United States)

    Minatel, Lurian; Verri, Fellippo Ramos; Kudo, Guilherme Abu Halawa; de Faria Almeida, Daniel Augusto; de Souza Batista, Victor Eduardo; Lemos, Cleidiel Aparecido Araujo; Pellizzer, Eduardo Piza; Santiago, Joel Ferreira

    2017-02-01

    A biomechanical analysis of different types of implant connections is relevant to clinical practice because it may impact the longevity of the rehabilitation treatment. Therefore, the objective of this study is to evaluate the Morse taper connections and the stress distribution of structures associated with the platform switching (PSW) concept. It will do this by obtaining data on the biomechanical behavior of the main structure in relation to the dental implant using the 3-dimensional finite element methodology. Four models were simulated (with each containing a single prosthesis over the implant) in the molar region, with the following specifications: M1 and M2 is an external hexagonal implant on a regular platform; M3 is an external hexagonal implant using PSW concept; and M4 is a Morse taper implant. The modeling process involved the use of images from InVesalius CT (computed tomography) processing software, which were refined using Rhinoceros 4.0 and SolidWorks 2011 CAD software. The models were then exported into the finite element program (FEMAP 11.0) to configure the meshes. The models were processed using NeiNastram software. The main results are that M1 (regular diameter 4mm) had the highest stress concentration area and highest microstrain concentration for bone tissue, dental implants, and the retaining screw (P<0.05). Using the PSW concept increases the area of the stress concentrations in the retaining screw (P<0.05) more than in the regular platform implant. It was concluded that the increase in diameter is beneficial for stress distribution and that the PSW concept had higher stress concentrations in the retaining screw and the crown compared to the regular platform implant. Copyright © 2016 Elsevier B.V. All rights reserved.

  16. Distribution and phylogenies of enzymes of the Embden-Meyerhof-Parnas pathway from archaea and hyperthermophilic bacteria support a gluconeogenic origin of metabolism.

    Science.gov (United States)

    Ronimus, Ron S; Morgan, Hugh W

    2003-10-01

    Enzymes of the gluconeogenic/glycolytic pathway (the Embden-Meyerhof-Parnas (EMP) pathway), the reductive tricarboxylic acid cycle, the reductive pentose phosphate cycle and the Entner-Doudoroff pathway are widely distributed and are often considered to be central to the origins of metabolism. In particular, several enzymes of the lower portion of the EMP pathway (the so-called trunk pathway), including triosephosphate isomerase (TPI; EC 5.3.1.1), glyceraldehyde-3-phosphate dehydrogenase (GAPDH; EC 1.2.1.12/13), phosphoglycerate kinase (PGK; EC 2.7.2.3) and enolase (EC 4.2.1.11), are extremely well conserved and universally distributed among the three domains of life. In this paper, the distribution of enzymes of gluconeogenesis/glycolysis in hyperthermophiles--microorganisms that many believe represent the least evolved organisms on the planet--is reviewed. In addition, the phylogenies of the trunk pathway enzymes (TPIs, GAPDHs, PGKs and enolases) are examined. The enzymes catalyzing each of the six-carbon transformations in the upper portion of the EMP pathway, with the possible exception of aldolase, are all derived from multiple gene sequence families. In contrast, single sequence families can account for the archaeal and hyperthermophilic bacterial enzyme activities of the lower portion of the EMP pathway. The universal distribution of the trunk pathway enzymes, in combination with their phylogenies, supports the notion that the EMP pathway evolved in the direction of gluconeogenesis, i.e., from the bottom up.

  17. Distribution and phylogenies of enzymes of the Embden-Meyerhof-Parnas pathway from archaea and hyperthermophilic bacteria support a gluconeogenic origin of metabolism

    Directory of Open Access Journals (Sweden)

    Ron S. Ronimus

    2003-01-01

    Full Text Available Enzymes of the gluconeogenic/glycolytic pathway (the Embden-Meyerhof-Parnas (EMP pathway, the reductive tricarboxylic acid cycle, the reductive pentose phosphate cycle and the Entner-Doudoroff pathway are widely distributed and are often considered to be central to the origins of metabolism. In particular, several enzymes of the lower portion of the EMP pathway (the so-called trunk pathway, including triosephosphate isomerase (TPI; EC 5.3.1.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH; EC 1.2.1.12/13, phosphoglycerate kinase (PGK; EC 2.7.2.3 and enolase (EC 4.2.1.11, are extremely well conserved and universally distributed among the three domains of life. In this paper, the distribution of enzymes of gluconeogenesis/glycolysis in hyperthermophiles—microorganisms that many believe represent the least evolved organisms on the planet—is reviewed. In addition, the phylogenies of the trunk pathway enzymes (TPIs, GAPDHs, PGKs and enolases are examined. The enzymes catalyzing each of the six-carbon transformations in the upper portion of the EMP pathway, with the possible exception of aldolase, are all derived from multiple gene sequence families. In contrast, single sequence families can account for the archaeal and hyperthermophilic bacterial enzyme activities of the lower portion of the EMP pathway. The universal distribution of the trunk pathway enzymes, in combination with their phylogenies, supports the notion that the EMP pathway evolved in the direction of gluconeogenesis, i.e., from the bottom up.

  18. Automatic measurement of contrast bolus distribution in carotid arteries using a C-arm angiography system to support interventional perfusion imaging

    Science.gov (United States)

    Fieselmann, Andreas; Ganguly, Arundhuti; Yu, Deuerling-Zheng; Boese, Jan; Hornegger, Joachim; Fahrig, Rebecca

    2011-03-01

    Brain perfusion CT using a C-arm angiography system capable of CT-like imaging could optimize patient treatment during stroke therapy procedures. For this application, an intra-arterial contrast bolus injection at the aortic arch could be used provided that the location of the injection catheter enables uniform distribution of the bolus into the two common carotid arteries (CCA). In this work, we present a novel method to support optimal injection catheter placement by providing additional quantitative information about the distribution of the contrast bolus into the CCAs. Our fully automatic method uses 2-D digital subtraction angiography (DSA) images following a test bolus injection. It segments both CCAs and computes the relative contrast distribution. We have tested the method in DSA data sets from 5 healthy pigs and our method achieved successful segmentation of both CCAs in all data sets. The results showed that the contrast is uniformly distributed (mean relative difference less or equal than 10%) if the injection location is properly chosen.

  19. Numerical analysis of the effect of hole size change in lower-support-structure-bottom plate on the reactor core-inlet flow-distribution

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Gong Hee [KORI Residence Inspection Team, Korea Institute of Nuclear Safety, Kori (Korea, Republic of); Bang, Young Seok; Cheong, Ae Ju [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2015-11-15

    In this study, to examine the effect of a hole size change(smaller hole diameter) in the outer region of the lower-support-structure-bottom plate(LSSBP) on the reactor core-inlet flow-distribution, simulations were conducted with the commercial CFD software, ANSYS CFX R.15. The predicted results were compared with those of the original LSSBP. Through these comparisons, it was concluded that a more uniform distribution of the mass flow rate at the core-inlet plane could be obtained by reducing the hole size in the outer region of the LSSBP. Therefore, from the nuclear regulatory perspective, design change of the hole pattern in the outer region of the LSSBP may be desirable in terms of improving both the mechanical integrity of the fuel assembly and the core thermal margin.

  20. Water Expert: a conceptualized framework for development of a rule-based decision support system for distribution system decontamination

    Directory of Open Access Journals (Sweden)

    J. L. Gutenson

    2014-05-01

    Full Text Available Significant drinking water contamination events pose a serious threat to public and environmental health. Water utilities often must make timely, critical decisions without evaluating all facets of the incident, as the data needed to enact informed decisions are inevitably dispersant and disparate, originating from policy, science, and heuristic contributors. Water Expert is a functioning hybrid decision support system (DSS and expert system framework, with emphases on meshing parallel data structures to expedite and optimize the decision pathway. Delivered as a thin-client application through the user's web browser, Water Expert's extensive knowledgebase is a product of inter-university collaboration that methodically pieced together system decontamination procedures through consultation with subject matter experts, literature review, and prototyping with stakeholders. This paper discusses development of Water Expert, analyzing the development process underlying the DSS and the system's existing architecture specifications.

  1. SUPPORTED ZIEGLER-NATTA CATALYSTS FOR ETHYLENE SLURRY POLYMERIZATION AND CONTROL OF MOLECULAR WEIGHT DISTRIBUTION OF POLYETHYLENE

    Institute of Scientific and Technical Information of China (English)

    Vladimir Zakharov; Ludmila Echevskaya; Tatiana Mikenas; Mikhail Matsko; Andrey Tregubov; Marina Vanina; Marina Nikolaeva

    2008-01-01

    The effect of chemical composition of highly active supported Ziegler-Natta catalysts with controlled morphology on the MWD of PE has been studied.It was shown the variation of transition metal compound in the MgCI2-supported catalyst affect of MWD of PE produced in broad range:Vanadium-magnesium catalyst(VMC)produce PE with broad and bimodal MWD(Mw、Mn=14-21).MWD of PE,produced over titanium-magnesium catalyst(TMC) is narrow or medium depending on Ti content in the catalyst(Mw/Mn=3.1-4.8).The oxidation state of the initial titanium compounds in TMC has only slight effeCt on MWD of PE produced.Based on MWD data of PE heterogeneity of active centers of TMC and VMC was studied.The results of resolution of experimental GPC curves into Flory components indicated three Flory components are snfficient to describe MWD curve of PE,produced with TMC:six Flory components are required in the case of VMC.In the case of copolymerization of ethylene with 1-hexene over TMC the addition of 1-hexene leads to decrease of MW and to slight effect on Mw/Mn values.On the contrary the strong effect of 1-hexene on MWD of PE produced over VMC was found:the introduction of 1-hexene results in considerable broadening of MWD due to the shifting of the main MWD peak tO low MW region.At that comonomer does not affect the position of high molecular weight shoulder The results indicate that some of active centers of VMC producing high MW polymer are not active in the reaction of chain transfer with comonomer.

  2. Distributed expertise: qualitative study of a British network of multidisciplinary teams supporting parents of children with chronic kidney disease.

    Science.gov (United States)

    Swallow, V; Smith, T; Webb, N J A; Wirz, L; Qizalbash, L; Brennan, E; Birch, A; Sinha, M D; Krischock, L; van der Voort, J; King, D; Lambert, H; Milford, D V; Crowther, L; Saleem, M; Lunn, A; Williams, J

    2015-01-01

    Long-term childhood conditions are often managed by hospital-based multidisciplinary teams (MDTs) of professionals with discipline specific expertise of a condition, in partnership with parents. However, little evidence exists on professional-parent interactions in this context. An exploration of professionals' accounts of the way they individually and collectively teach parents to manage their child's clinical care at home is, therefore, important for meeting parents' needs, informing policy and educating novice professionals. Using chronic kidney disease as an exemplar this paper reports on one aspect of a study of interactions between professionals and parents in a network of 12 children's kidney units in Britain. We conducted semi-structured, qualitative interviews with a convenience sample of 112 professionals (clinical-psychologists, dietitians, doctors, nurses, pharmacists, play-workers, therapists and social workers), exploring accounts of their parent-educative activity. We analysed data using framework and the concept of distributed expertise. Four themes emerged that related to the way expertise was distributed within and across teams: (i) recognizing each other's' expertise, (ii) sharing expertise within the MDT, (iii) language interpretation, and (iv) acting as brokers. Two different professional identifications were also seen to co-exist within MDTs, with participants using the term 'we' both as the intra-professional 'we' (relating to the professional identity) when describing expertise within a disciplinary group (for example: 'As dietitians we aim to give tailored advice to optimize children's growth'), and the inter-professional 'we' (a 'team-identification'), when discussing expertise within the team (for example: 'We work as a team and make sure we're all happy with every aspect of their training before they go home'). This study highlights the dual identifications implicit in 'being professional' in this context (to the team and to one

  3. Phylogenetic distribution of microRNAs supports the basal position of acoel flatworms and the polyphyly of Platyhelminthes.

    Science.gov (United States)

    Sempere, Lorenzo F; Martinez, Pedro; Cole, Charles; Baguñà, Jaume; Peterson, Kevin J

    2007-01-01

    Phylogenetic analyses based on gene sequences suggest that acoel flatworms are not members of the phylum Platyhelminthes, but instead are the most basal branch of triploblastic bilaterians. Nonetheless, this result has been called into question. An alternative test is to use qualitative molecular markers that should, in principle, exclude the possibility of convergent (homoplastic) evolution in unrelated groups. microRNAs (miRNAs), noncoding regulatory RNA molecules that are under intense stabilizing selection, are a newly discovered set of phylogenetic markers that can resolve such taxonomic disputes. The acoel Childia sp. has recently been shown to possess a subset of the conserved core of miRNAs found across deuterostomes and protostomes, whereas a polyclad flatworm-in addition to this core subset-possesses miRNAs restricted to just protostomes. Here, we examine another acoel, Symsagittifera roscoffensis, and three other platyhelminths. Our results show that the distribution of miRNAs in S. roscoffensis parallels that of Childia. In addition, two of 13 new miRNAs cloned from a triclad flatworm are also found in other lophotrochozoan protostomes, but not in ecdysozoans, deuterostomes, or in basal metazoans including acoels. The limited set of miRNAs found in acoels, intermediate between the even more reduced set in cnidarians and the larger and expanding set in the rest of bilaterians, is compelling evidence for the basal position of acoel flatworms and the polyphyly of Platyhelminthes.

  4. Building a Data Set over 12 Globally Distributed Sites to Support the Development of Agriculture Monitoring Applications with Sentinel-2

    Directory of Open Access Journals (Sweden)

    Sophie Bontemps

    2015-12-01

    Full Text Available Developing better agricultural monitoring capabilities based on Earth Observation data is critical for strengthening food production information and market transparency. The Sentinel-2 mission has the optimal capacity for regional to global agriculture monitoring in terms of resolution (10–20 meter, revisit frequency (five days and coverage (global. In this context, the European Space Agency launched in 2014 the “Sentinel­2 for Agriculture” project, which aims to prepare the exploitation of Sentinel-2 data for agriculture monitoring through the development of open source processing chains for relevant products. The project generated an unprecedented data set, made of “Sentinel-2 like” time series and in situ data acquired in 2013 over 12 globally distributed sites. Earth Observation time series were mostly built on the SPOT4 (Take 5 data set, which was specifically designed to simulate Sentinel-2. They also included Landsat 8 and RapidEye imagery as complementary data sources. Images were pre-processed to Level 2A and the quality of the resulting time series was assessed. In situ data about cropland, crop type and biophysical variables were shared by site managers, most of them belonging to the “Joint Experiment for Crop Assessment and Monitoring” network. This data set allowed testing and comparing across sites the methodologies that will be at the core of the future “Sentinel­2 for Agriculture” system.

  5. DataONE: A Distributed Environmental and Earth Science Data Network Supporting the Full Data Life Cycle

    Science.gov (United States)

    Cook, R.; Michener, W.; Vieglais, D.; Budden, A.; Koskela, R.

    2012-04-01

    Addressing grand environmental science challenges requires unprecedented access to easily understood data that cross the breadth of temporal, spatial, and thematic scales. Tools are needed to plan management of the data, discover the relevant data, integrate heterogeneous and diverse data, and convert the data to information and knowledge. Addressing these challenges requires new approaches for the full data life cycle of managing, preserving, sharing, and analyzing data. DataONE (Observation Network for Earth) represents a virtual organization that enables new science and knowledge creation through preservation and access to data about life on Earth and the environment that sustains it. The DataONE approach is to improve data collection and management techniques; facilitate easy, secure, and persistent storage of data; continue to increase access to data and tools that improve data interoperability; disseminate integrated and user-friendly tools for data discovery and novel analyses; work with researchers to build intuitive data exploration and visualization tools; and support communities of practice via education, outreach, and stakeholder engagement.

  6. Ion Exchange Distribution Coefficient Tests and Computer Modeling at High Ionic Strength Supporting Technetium Removal Resin Maturation

    Energy Technology Data Exchange (ETDEWEB)

    Nash, Charles A. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Hamm, L. Larry [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Smith, Frank G. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); McCabe, Daniel J. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2014-12-19

    The primary treatment of the tank waste at the DOE Hanford site will be done in the Waste Treatment and Immobilization Plant (WTP) that is currently under construction. The baseline plan for this facility is to treat the waste, splitting it into High Level Waste (HLW) and Low Activity Waste (LAW). Both waste streams are then separately vitrified as glass and poured into canisters for disposition. The LAW glass will be disposed onsite in the Integrated Disposal Facility (IDF). There are currently no plans to treat the waste to remove technetium, so its disposition path is the LAW glass. Due to the water solubility properties of pertechnetate and long half-life of 99Tc, effective management of 99Tc is important to the overall success of the Hanford River Protection Project mission. To achieve the full target WTP throughput, additional LAW immobilization capacity is needed, and options are being explored to immobilize the supplemental LAW portion of the tank waste. Removal of 99Tc, followed by off-site disposal, would eliminate a key risk contributor for the IDF Performance Assessment (PA) for supplemental waste forms, and has potential to reduce treatment and disposal costs. Washington River Protection Solutions (WRPS) is developing some conceptual flow sheets for supplemental LAW treatment and disposal that could benefit from technetium removal. One of these flowsheets will specifically examine removing 99Tc from the LAW feed stream to supplemental immobilization. To enable an informed decision regarding the viability of technetium removal, further maturation of available technologies is being performed. This report contains results of experimental ion exchange distribution coefficient testing and computer modeling using the resin SuperLig® 639a to selectively remove perrhenate from high ionic strength simulated LAW. It is advantageous to operate at higher concentration in order to treat the waste

  7. Enabling the Distributed Generation Market of High Temperature Fuel Cell and Absorption Chiller Systems to Support Critical and Commercial Loads

    Science.gov (United States)

    DiMola, Ashley M.

    Buildings account for over 18% of the world's anthropogenic Greenhouse Gas (GHG) emissions. As a result, a technology that can offset GHG emissions associated with buildings has the potential to save over 9 Giga-tons of GHG emissions per year. High temperature fuel cell and absorption chiller (HTFC/AC) technology offers a relatively low-carbon option for meeting cooling and electric loads for buildings while producing almost no criteria pollutants. GHG emissions in the state of California would decrease by 7.48 million metric tons per year if every commercial building in the State used HTFC/AC technology to meet its power and cooling requirements. In order to realize the benefits of HTFC/AC technology on a wide scale, the distributed generation market needs to be exposed to the technology and informed of its economic viability and real-world potential. This work characterizes the economics associated with HTFC/AC technology using select scenarios that are representative of realistic applications. The financial impacts of various input factors are evaluated and the HTFC/AC simulations are compared to the economics of traditional building utilities. It is shown that, in addition to the emissions reductions derived from the systems, HTFC/AC technology is financially preferable in all of the scenarios evaluated. This work also presents the design of a showcase environment, centered on a beta-test application, that presents (1) system operating data gathered using a custom data acquisition module, and (2) HTFC/AC technology in a clear and approachable manner in order to serve the target audience of market stakeholders.

  8. Analysis of the distribution of stress and deformation in single implant-supported prosthetic units in implants of different diameters

    Directory of Open Access Journals (Sweden)

    Francesco Salvatore MANNARINO

    Full Text Available Abstract Introduction When stress and strain levels in the bone-implant system exceed It's capacity, a mechanical fatigue occurs, resulting in collapse and loss of osseointegration. Objective Analyze biomechanical behavior in single implant-supported prosthesis with implants of different diameters in the posterior mandible. Material and method Three different finite element models of Cone-Morse implants with the same height were created, varying the diameter (3.3 mm, 4.1 mm and 4.8 mm. The mandibular first molar area was the location of the implant, with It´s component and overlying prosthetic crown. The jawbone was composed of cortical and cancellous bone. Refined mesh of 0.5 mm was created in the critical interfaces to be analyzed. The loading of the models was performed at the point of occlusal contact with an occlusal load of 400 N. Result Maximum stress and strain occurred in the cervical regions of the implants in all groups, either in the implants or in components as well as in the analysis of cortical bone. The greater the diameter, the lower the stress and strain found in the implant. The 3.3 mm group had the highest strain in peri-implant cortical bone, and the 4.1 mm group had the smallest deformation, significantly lower than in the 4.8 mm group. Conclusion Although the biggest implant diameter (4.8 mm appears to have lower values of stress and strain, the group of intermediate implant diameter (4.1 mm showed less deformation rate in the cortical peri-implant bone. Therefore it is concluded that the 4.1 mm implant platform presented a more biomechanically effective peri-implant bone maintenance.

  9. The limit distribution in the q-CLT for q\\,\\geqslant \\,1 is unique and can not have a compact support

    Science.gov (United States)

    Umarov, Sabir; Tsallis, Constantino

    2016-10-01

    In a paper by Umarov et al (2008 Milan J. Math. 76 307-28), a generalization of the Fourier transform, called the q-Fourier transform, was introduced and applied for the proof of a q-generalized central limit theorem (q-CLT). Subsequently, Hilhorst illustrated (2009 Braz. J. Phys. 39 371-9 2010 J. Stat. Mech. P10023) that the q-Fourier transform for q\\gt 1, is not invertible in the space of density functions. Indeed, using an invariance principle, he constructed a family of densities with the same q-Fourier transform and noted that ‘as a consequence, the q-CLT falls short of achieving its stated goal’. The distributions constructed there have compact support. We prove now that the limit distribution in the q-CLT is unique and can not have a compact support. This result excludes all the possible counterexamples which can be constructed using the invariance principle and fills the gap mentioned by Hilhorst.

  10. Effects of Supported ( n BuCp) 2 ZrCl 2 Catalyst Active-Center Distribution on Ethylene–1-Hexene Copolymer Backbone Heterogeneity and Thermal Behaviors

    KAUST Repository

    Atiqullah, Muhammad

    2013-07-10

    Two catalysts, denoted as catalyst 1 [silica/MAO/(nBuCp) 2ZrCl2] and catalyst 2 [silica/nBuSnCl 3/MAO/(nBuCp)2ZrCl2] were synthesized and subsequently used to prepare, without separate feeding of methylaluminoxane (MAO), ethylene homopolymer 1 and homopolymer 2, respectively, and ethylene-1-hexene copolymer 1 and copolymer 2, respectively. Gel permeation chromatography (GPC), Crystaf, differential scanning calorimetry (DSC) [conventional and successive self-nucleation and annealing (SSA)], and 13C nuclear magnetic resonance (NMR) polymer characterization results were used, as appropriate, to model the catalyst active-center distribution, ethylene sequence (equilibrium crystal) distribution, and lamellar thickness distribution (both continuous and discrete). Five different types of active centers were predicted in each catalyst, as corroborated by the SSA experiments and complemented by an extended X-ray absorption fine structure (EXAFS) report published in the literature. 13C NMR spectroscopy also supported this active-center multiplicity. Models combined with experiments effectively illustrated how and why the active-center distribution and the variance in the design of the supported MAO anion, having different electronic and steric effects and coordination environments, influence the concerned copolymerization mechanism and polymer properties, including inter- and intrachain compositional heterogeneity and thermal behaviors. Copolymerization occurred according to the first-order Markovian terminal model, producing fairly random copolymers with minor skewedness toward blocky character. For each copolymer, the theoretical most probable ethylene sequences, nE MPDSC-GT and n E MPNMR-Flory, as well as the weight-average lamellar thicknesses, Lwav DSC-GT and Lwav SSA DSC, were found to be comparable. To the best of our knowledge, such a match has not previously been reported. The percentage crystallinities of the homo- and copolymers increased linearly as a function of

  11. Design and baseline findings of a multi-site non-randomized evaluation of the effect of a health programme on microfinance clients in India.

    Science.gov (United States)

    Saha, Somen

    2013-10-12

    Microfinance is the provision of financial services for the poor. Health program through microfinance has the potential to address several access barriers to health. We report the design and baseline findings of a multi-site non-randomized evaluation of the effect of a health program on the members of two microfinance organizations from Karnataka and Gujarat states of India. Villages identified for roll-out of health services with microfinance were pair-matched with microfinance only villages. A quantitative survey at inception and twelve months post health intervention compare the primary outcome (incidence of childhood diarrhea), and secondary outcome (place of last delivery, toilet at home, and out-of-pocket expenditure on treatment). At baseline, the intervention and comparison communities were similar except for out-of-pocket expenditure on health. Low reported use of toilet at home indicates the areas are heading towards a sanitation crisis. This should be an area of program priority for the microfinance organizations. While respondents primarily rely on their savings for meeting treatment expenditure, borrowing from friends, relatives, and money-lenders remains other important source of meeting treatment expenditure in the community. Programs need to prioritize steps to ensure awareness about national health insurance schemes, entitlement to increase service utilization, and developing additional health financing safety nets for financing outpatient care, that are responsible for majority of health-debt. Finally we discuss implications of such programs for national policy makers.

  12. Validation of the k-filtering technique for a signal composed of random phase plane waves and non-random coherent structures

    Directory of Open Access Journals (Sweden)

    O. W. Roberts

    2014-08-01

    Full Text Available Recent observations of astrophysical magnetic fields have shown the presence of fluctuations being wave-like (propagating in the plasma frame and those described as being structure-like (advected by the plasma bulk velocity. Typically with single spacecraft missions it is impossible to differentiate between these two fluctuations, due to the inherent spatio-temporal ambiguity associated with a single point measurement. However missions such as Cluster which contain multiple spacecraft have allowed temporal and spatial changes to be resolved, with techniques such as the k-filtering technique. While this technique does not assume Taylor's hypothesis as is necessary with single spacecraft missions, it does require weak stationarity of the time series, and that the fluctuations can be described by a superposition of plane waves with random phase. In this paper we test whether the method can cope with a synthetic signal which is composed of a combination of non-random phase coherent structures with a mean radius d and a mean separation λ, as well as plane waves with random phase.

  13. Validation of the k-filtering technique for a signal composed of random-phase plane waves and non-random coherent structures

    Directory of Open Access Journals (Sweden)

    O. W. Roberts

    2014-12-01

    Full Text Available Recent observations of astrophysical magnetic fields have shown the presence of fluctuations being wave-like (propagating in the plasma frame and those described as being structure-like (advected by the plasma bulk velocity. Typically with single-spacecraft missions it is impossible to differentiate between these two fluctuations, due to the inherent spatio-temporal ambiguity associated with a single point measurement. However missions such as Cluster which contain multiple spacecraft have allowed for temporal and spatial changes to be resolved, using techniques such as k filtering. While this technique does not assume Taylor's hypothesis it requires both weak stationarity of the time series and that the fluctuations can be described by a superposition of plane waves with random phases. In this paper we test whether the method can cope with a synthetic signal which is composed of a combination of non-random-phase coherent structures with a mean radius d and a mean separation λ, as well as plane waves with random phase.

  14. Estimating the treatment effect from non-randomized studies: The example of reduced intensity conditioning allogeneic stem cell transplantation in hematological diseases

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    Resche-Rigon Matthieu

    2012-08-01

    Full Text Available Abstract Background In some clinical situations, for which RCT are rare or impossible, the majority of the evidence comes from observational studies, but standard estimations could be biased because they ignore covariates that confound treatment decisions and outcomes. Methods Three observational studies were conducted to assess the benefit of Allo-SCT in hematological malignancies of multiple myeloma, follicular lymphoma and Hodgkin’s disease. Two statistical analyses were performed: the propensity score (PS matching approach and the inverse probability weighting (IPW approach. Results Based on PS-matched samples, a survival benefit in MM patients treated by Allo-SCT, as compared to similar non-allo treated patients, was observed with an HR of death at 0.35 (95%CI: 0.14-0.88. Similar results were observed in HD, 0.23 (0.07-0.80 but not in FL, 1.28 (0.43-3.77. Estimated benefits of Allo-SCT for the original population using IPW were erased in HR for death at 0.72 (0.37-1.39 for MM patients, 0.60 (0.19-1.89 for HD patients, and 2.02 (0.88-4.66 for FL patients. Conclusion Differences in estimated benefits rely on whether the underlying population to which they apply is an ideal randomized experimental population (PS or the original population (IPW. These useful methods should be employed when assessing the effects of innovative treatment in non-randomized experiments.

  15. An Ant Colony Optimization algorithm for solving the fixed destination multi-depot multiple traveling salesman problem with non-random parameters

    Science.gov (United States)

    Ramadhani, T.; Hertono, G. F.; Handari, B. D.

    2017-07-01

    The Multiple Traveling Salesman Problem (MTSP) is the extension of the Traveling Salesman Problem (TSP) in which the shortest routes of m salesmen all of which start and finish in a single city (depot) will be determined. If there is more than one depot and salesmen start from and return to the same depot, then the problem is called Fixed Destination Multi-depot Multiple Traveling Salesman Problem (MMTSP). In this paper, MMTSP will be solved using the Ant Colony Optimization (ACO) algorithm. ACO is a metaheuristic optimization algorithm which is derived from the behavior of ants in finding the shortest route(s) from the anthill to a form of nourishment. In solving the MMTSP, the algorithm is observed with respect to different chosen cities as depots and non-randomly three parameters of MMTSP: m, K, L, those represents the number of salesmen, the fewest cities that must be visited by a salesman, and the most number of cities that can be visited by a salesman, respectively. The implementation is observed with four dataset from TSPLIB. The results show that the different chosen cities as depots and the three parameters of MMTSP, in which m is the most important parameter, affect the solution.

  16. An open-label, non-randomized comparison of venlafaxine and gabapentin as monotherapy or adjuvant therapy in the management of neuropathic pain in patients with peripheral neuropathy

    Directory of Open Access Journals (Sweden)

    William Eardley

    2010-04-01

    Full Text Available William Eardley, Cory TothDepartment of Clinical Neurosciences and the University of Calgary, Calgary, AB, CanadaAbstract: Although many therapies are used in the management of neuropathic pain (NeP due to polyneuropathy (PN, few comparison studies exist. We performed a prospective, non-randomized, unblended, efficacy comparison of the serotonin-norepinephrine reuptake inhibitor venlafaxine, as either monotherapy or adjuvant therapy, with a first-line medication for NeP, gabapentin, in patients with PN-related NeP. VAS pain scores were assessed after 3 and 6 months in intervention groups and in a cohort of patients receiving no pharmacotherapy. In a total of 223 patients, we analyzed pain quantity and quality (visual analogue scale [VAS] score, Brief Pain Inventory [BPI], quality of life and health status measures [EuroQol 5 Domains, EQ-5D], Medical Outcomes Sleep Study Scale [MOSSS], Hospital Anxiety and Depression Scale [HADS] and Short Form 36 Health Survey [SF-36] after 6 months of therapy. Significant improvements in VAS pain scores occurred for all treatment groups after 6 months. Improvements in aspects of daily life and anxiety were identified in all treatment groups. Our data suggest that monotherapy or adjuvant therapy with venlafaxine is comparable to gabapentin for NeP management. We advocate for head-to-head, randomized, double-blinded studies of current NeP therapies.Keywords: peripheral neuropathy, neuropathic pain, pharmacotherapy, venlafaxine, gabapentin

  17. Cloning of ribosomal ITS PCR products creates frequent, non-random chimeric sequences – a test involving heterozygotes between Gymnopus dichrous taxa I and II

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    Karen W. Hughes

    2015-06-01

    Full Text Available Gymnopus dichrous exists in the southern Appalachians (USA as two distinct entities with essentially identical nuclear ribosomal ITS1 sequences but differing ITS2 and LSU sequences (for convenience, called G. dichrous I and II. F1 ITS heterozygotes between the two are routinely collected from nature. Cloning of ITS PCR products from F1 heterozygotes produced sequences of both parental haplotypes but also numerous chimeric sequences (21.9%. The location of template switching was non-random leading to recovery of the same chimera several times and the chimeric region varied from 45bp to 300bp. By comparison, single-basidiospore isolates from heterozygote F1 fruitbodies showed no recombinant haplotypes within the ITS + LSU span and clones derived from P1 homozygotes were identical to the P1 parent. Thus, chimeric sequences are likely an artifact of the PCR-cloning process and not a consequence of natural recombination events found in nature, nor are they due to hidden existing variation within the ribosomal repeat. Chimeras and PCR-induced mutations are common in cloned PCR products and may result in incorrect sequence information in public databases.

  18. Effects of different frequencies (2-3 days/week) of aquatic therapy program in adults with chronic low back pain. A non-randomized comparison trial.

    Science.gov (United States)

    Baena-Beato, Pedro Angel; Arroyo-Morales, Manuel; Delgado-Fernández, Manuel; Gatto-Cardia, Maria Claudia; Artero, Enrique G

    2013-01-01

    To study the effects of an aquatic therapy program with different frequencies (2 vs 3 days per week) in chronic low back pain. [corrected] Non-randomized comparison trial. Sport and spa community health club. Fifty-four adults with chronic low back pain (48.9 ± 10.0 years). Eight-week aquatic therapy program. Pain (visual analog scale [VAS]), disability (Oswestry Disability Index), and quality of life (Short-Form Health Survey 36), body composition (weight, body mass index, body fat mass, body fat percentage, and skeletal muscle mass), and health-related fitness (sit and reach, handgrip strength, curl-up, Rockport 1-mile test). Both experimental groups presented significant improvements in low back pain and disability (P aquatic therapy program decrease levels of back pain and disability, increase quality of life, and improve health-related fitness in adults with chronic low back pain without effects in body composition. A dose-response effect was observed in some parameters, with greater benefits when exercising 3 days per week compared with 2 days. Wiley Periodicals, Inc.

  19. Bifidobacterium bifidum OLB6378 Simultaneously Enhances Systemic and Mucosal Humoral Immunity in Low Birth Weight Infants: A Non-Randomized Study

    Science.gov (United States)

    Tanaka, Katsunori; Tsukahara, Takamitsu; Yanagi, Takahide; Nakahara, Sayuri; Furukawa, Ouki; Tsutsui, Hidemi; Koshida, Shigeki

    2017-01-01

    Probiotic supplementation has been part of the discussion on methods to enhance humoral immunity. Administration of Bifidobacterium bifidum OLB6378 (OLB6378) reduced the incidence of late-onset sepsis in infants. In this non-randomized study, we aimed to determine the effect of administration of live OLB6378 on infants’ humoral immunity. Secondly, we tried to elucidate whether similar effects would be observed with administration of non-live OLB6378. Low birth weight (LBW) infants weighing 1500–2500 g were divided into three groups: Group N (no intervention), Group L (administered live OLB6378 concentrate), and Group H (administered non-live OLB6378 concentrate). The interventions were started within 48 h after birth and continued until six months of age. Serum immunoglobulin G (IgG) levels (IgG at one month/IgG at birth) were significantly higher in Group L than in Group N (p food ingredient, showed a more marked effect than the viable bacteria. PMID:28245626

  20. PROSPECTIVE OBSERVATIONAL, NON-RANDOMIZED, PARALLEL SEQUENCE STUDY FOR ASSESSMENT OF ADVERSE DRUG REACTIONS DUE TO CHEMOTHERAPEUTIC TREATMENT IN DIFFERENT TYPES OF CANCER PATIENTS

    Directory of Open Access Journals (Sweden)

    Mrugank B.P. * and Hareesha R.P.

    2013-01-01

    Full Text Available Objective: To assess incidence, causality, severity, predictability and preventability of adverse drug reactions (ADRs in hospitalised oncology patients.Materials and Methods: A prospective observational, non-randomized, parallel sequence study was conducted at Dr B. Borooah Cancer Institute (BBCI after getting an approval from human ethical committee. Patients hospitalised at BBCI from Aug 2010 to June 2011 were interviewed about symptoms related to their drug therapy. Patient medical records were also reviewed for data collection.Results: Total 663 patients associated with hospitalizations were interviewed. 899 ADRs were identified in total 410 (61.84% patients detected with ADRs. Most of all ADRs were moderate, predictable and not preventable. The most common ADRs were leucopenia, weakness, anorexia, alopecia, vomiting, diarrhoea, nausea, abdominal pain, fatigue, and anaemia in this study.Conclusions: For definite conclusion study should be repeated. Strict drug analyzing and in vivo study is also required if feasible.Key message: The process of defining and concluding about ADRs should be continuous and ongoing to keep a record of newly marketed drugs and medicinal products.

  1. Bifidobacterium bifidum OLB6378 Simultaneously Enhances Systemic and Mucosal Humoral Immunity in Low Birth Weight Infants: A Non-Randomized Study

    Directory of Open Access Journals (Sweden)

    Katsunori Tanaka

    2017-02-01

    Full Text Available Probiotic supplementation has been part of the discussion on methods to enhance humoral immunity. Administration of Bifidobacterium bifidum OLB6378 (OLB6378 reduced the incidence of late-onset sepsis in infants. In this non-randomized study, we aimed to determine the effect of administration of live OLB6378 on infants’ humoral immunity. Secondly, we tried to elucidate whether similar effects would be observed with administration of non-live OLB6378. Low birth weight (LBW infants weighing 1500–2500 g were divided into three groups: Group N (no intervention, Group L (administered live OLB6378 concentrate, and Group H (administered non-live OLB6378 concentrate. The interventions were started within 48 h after birth and continued until six months of age. Serum immunoglobulin G (IgG levels (IgG at one month/IgG at birth were significantly higher in Group L than in Group N (p < 0.01. Group H exhibited significantly higher serum IgG levels (p < 0.01 at one month of age and significantly higher intestinal secretory immunoglobulin A (SIgA levels (p < 0.05 at one and two months of age than Group N. No difference was observed in the mortality or morbidity between groups. Thus, OLB6378 administration in LBW infants enhanced humoral immunity, and non-live OLB6378, which is more useful as a food ingredient, showed a more marked effect than the viable bacteria.

  2. Using an extreme bony prominence anatomical model to examine the influence of bed sheet materials and bed making methods on the distribution of pressure on the support surface.

    Science.gov (United States)

    Iuchi, Terumi; Nakajima, Yukari; Fukuda, Moriyoshi; Matsuo, Junko; Okamoto, Hiroyuki; Sanada, Hiromi; Sugama, Junko

    2014-05-01

    Bed sheets generate high surface tension across the support surface and increase pressure to the body through a process known as the hammock effect. Using an anatomical model and a loading device characterized by extreme bony prominences, the present study compared pressure distributions on support surfaces across different bed making methods and bed sheet materials to determine the factors that influence pressure distribution. The model was placed on a pressure mapping system (CONFORMat; NITTA Corp., Osaka, Japan), and interface pressure was measured. Bed sheet elasticity and friction between the support surface and the bed sheets were also measured. For maximum interface pressure, the relative values of the following methods were higher than those of the control method, which did not use any bed sheets: cotton sheets with hospital corners (1.28, p = 0.02), polyester with no corners (1.29, p = 0.01), cotton with no corners (1.31, p = 0.003), and fitted polyester sheets (1.35, p = 0.002). Stepwise multiple regression analysis indicated that maximum interface pressure was negatively correlated with bed sheet elasticity (R(2) = 0.74). A statistically significant negative correlation was observed between maximum interface pressure and immersion depth, which was measured using the loading device (r = -0.40 and p = 0.04). We found that several combinations of bed making methods and bed sheet materials induced maximum interface pressures greater than those observed for the control method. Bed sheet materials influenced maximum interface pressure, and bed sheet elasticity was particularly important in reducing maximum interface pressure.

  3. Effect of the number of implants on stress distribution of anterior implant-supported fixed prostheses combined with a removable partial denture: a finite element analysis.

    Directory of Open Access Journals (Sweden)

    Minoo Mahshid

    2014-06-01

    Full Text Available The main goal of this study was to evaluate differences in stress distribution relevant to the number of implants under an anterior bridge when combined with a removable partial denture in the posterior region.Four three-dimensional finite element models (3D FEM were designed from a mandible containing an implant-supported bridge extending between canines, and a bilateral distal extension removable partial denture. A nonrigid connection was selected as the attachment method between the partial denture and the anterior implant-supported fixed prosthesis; 2, 3, 4 and 5 implants supporting the bridge all with 10mm length and 3.8 mm diameter were assessed. With the aid of the finite element program ANSYS 8.0, the models were loaded and von Mises stresses were evaluated.In spongy bone, stress forces showed a decrease from 2 implants to 4 implants but showed an increase in the 5-implant model. Stresses on cortical bone of terminal implants were in similar range in the 2-, 3- and 4-implant models. While, in the 5-implant model the amount of stresses on terminal implants increased dramatically. The stresses on implants were nearly similar in all models, with the greatest amount on terminal implants.Within the limitations of this study, 2-, 3- and 4-implant models showed less stress on cortical and spongy bone in comparison with the 5-implant model. The stresses transferred to implants were nearly similar.

  4. Further development and implementation of the DIWA distributed hydrological model-based integrated hydroinformatics system in the Danube River Basin for supporting decision making in water management

    Science.gov (United States)

    Szabó, J. A.; Réti, G. Z.; Tóth, T.

    2012-04-01

    Today, the most significant mission of the decision makers on integrated water management issues is to carry out sustainable management for sharing the resources between a variety of users and the environment under conditions of considerable uncertainty (such as climate/land use/population/etc. change) conditions. In light of this increasing water management complexity, we consider that the most pressing needs is to develop and implement up-to-date Spatial Decision Support Systems (SDSS) for aiding decision-making processes to improve water management. One of the most important parts of such an SDSS is a distributed hydrologic model-based integrated hydroinformatics system to analyze the different scenarios. The less successful statistical and/or empirical model-experiments of earlier decades have highlighted the importance of paradigm shift in hydrological modelling approach towards the physically based distributed models, to better describe the complex hydrological processes even on catchments of more ten thousands of square km. Answers to questions like what are the effects of human actions in the catchment area (e. g. forestation or deforestation) or the changing of climate/land use on the flood, drought, or water scarcity, or what is the optimal strategy for planning and/or operating reservoirs, have become increasingly important. Nowadays the answers to this kind of questions can be provided more easily than before. The progress of applied mathematical methods, the advanced state of computer technology as well as the development of remote sensing and meteorological radar technology have accelerated the research capable of answering these questions using well-designed integrated hydroinformatics systems. With most emphasis on the recent years of extensive scientific and computational development HYDROInform UnLtd developed a distributed hydrological model-based integrated hydroinformatics system for supporting the various decisions in water management. Our

  5. Effective Group Training for Patients with Unexplained Physical Symptoms: A Randomized Controlled Trial with a Non-Randomized One-Year Follow-Up

    Science.gov (United States)

    Zonneveld, Lyonne N. L.; van Rood, Yanda R.; Timman, Reinier; Kooiman, Cornelis G.; van't Spijker, Adriaan; Busschbach, Jan J. V.

    2012-01-01

    Background Although cognitive-behavioral therapy for Unexplained Physical Symptoms (UPS) is effective in secondary care, studies done in primary care produced implementation problems and conflicting results. We evaluated the effectiveness of a cognitive-behavioral group training tailored to primary care patients and provided by a secondary community mental-health service reaching out into primary care. Methodology/Principal Findings The effectiveness of this training was explored in a randomized controlled trial. In this trial, 162 patients with UPS classified as undifferentiated somatoform disorder or as chronic pain disorder were randomized either to the training or a waiting list. Both lasted 13 weeks. The preservation of the training's effect was analyzed in non-randomized follow-ups, for which the waiting group started the training after the waiting period. All patients attended the training were followed-up after three months and again after one year. The primary outcomes were the physical and the mental summary scales of the SF-36. Secondary outcomes were the other SF-36-scales and the SCL-90-R. The courses of the training's effects in the randomized controlled trial and the follow-ups were analyzed with linear mixed modeling. In the randomized controlled trial, the training had a significantly positive effect on the quality of life in the physical domain (Cohen's d = 0.38;p = .002), but this overall effect was not found in the mental domain. Regarding the secondary outcomes, the training resulted in reporting an improved physical (Cohen's d = 0.43;p = 0.01), emotional (Cohen's d = 0.44;p = .0.01), and social (Cohen's d = 0.36;p = 0.01) functioning, less pain and better functioning despite pain (Cohen's d = 0.51;p =  PMID:22880056

  6. Effective group training for patients with unexplained physical symptoms: a randomized controlled trial with a non-randomized one-year follow-up.

    Directory of Open Access Journals (Sweden)

    Lyonne N L Zonneveld

    Full Text Available BACKGROUND: Although cognitive-behavioral therapy for Unexplained Physical Symptoms (UPS is effective in secondary care, studies done in primary care produced implementation problems and conflicting results. We evaluated the effectiveness of a cognitive-behavioral group training tailored to primary care patients and provided by a secondary community mental-health service reaching out into primary care. METHODOLOGY/PRINCIPAL FINDINGS: The effectiveness of this training was explored in a randomized controlled trial. In this trial, 162 patients with UPS classified as undifferentiated somatoform disorder or as chronic pain disorder were randomized either to the training or a waiting list. Both lasted 13 weeks. The preservation of the training's effect was analyzed in non-randomized follow-ups, for which the waiting group started the training after the waiting period. All patients attended the training were followed-up after three months and again after one year. The primary outcomes were the physical and the mental summary scales of the SF-36. Secondary outcomes were the other SF-36-scales and the SCL-90-R. The courses of the training's effects in the randomized controlled trial and the follow-ups were analyzed with linear mixed modeling. In the randomized controlled trial, the training had a significantly positive effect on the quality of life in the physical domain (Cohen's d = 0.38;p = .002, but this overall effect was not found in the mental domain. Regarding the secondary outcomes, the training resulted in reporting an improved physical (Cohen's d = 0.43;p = 0.01, emotional (Cohen's d = 0.44;p = 0.01, and social (Cohen's d = 0.36;p = 0.01 functioning, less pain and better functioning despite pain (Cohen's d = 0.51;p =

  7. Efficacy of Health Education using Facebook to Promote Healthy Lifestyle among Medical Students in Puducherry, India: A Non-Randomized Controlled Trial.

    Science.gov (United States)

    Krishnamohan, Smrithi; Stalin, P; Singh, Zile; Sridhar, Maghida

    2017-07-01

    Increasing burden of overweight and obesity among young adults is mainly due to unhealthy lifestyle especially with respect to diet and physical activity. At the same time, younger generations are spending more time with social network sites. Therefore, this study was intended to explore the role of social networking sites in promoting healthy lifestyle. To measure the efficacy of health education using social networking sites in promoting healthy lifestyle among medical students in Puducherry, India. A non-randomized controlled trial was conducted in a private medical college located in Puducherry. The study participants were overweight/obese individuals with (intervention arm) and without Facebook account (control arm). Following a baseline survey, both the groups received health education from dietician and physical trainer using Audiovisual (AV) aids. Intervention group received health education through Facebook in the forms of messages, pictures and videos for six weeks. Then, follow up survey was done to assess the change in dietary pattern, physical activity and body weight. Data of those who attended baseline, intervention and follow up surveys (23- control and 22- intervention) were analysed. Means and proportions were calculated. Paired t-test and Chi-square test were used to calculate the p-value. The p-valuejunk food intake per week was reduced in both control and intervention groups from 2.91 days/week and 3.27 days/week at baseline to 2.65 days/week to two days/week at follow up respectively. A significant decrease in the Body Mass Index (BMI) (pactivity and intake of fruits and vegetables. Except for the decrease in junk food intake, use of Facebook as an effective tool to promote healthy lifestyle could not be proved with confidence.

  8. Effect of cognitive behavioral group therapy for recovery of self-esteem on community-living individuals with mental illness: Non-randomized controlled trial.

    Science.gov (United States)

    Kunikata, Hiroko; Yoshinaga, Naoki; Nakajima, Kazuo

    2016-10-01

    The aim of this study was to examine over a 12-month post-intervention period whether the participation of community-living individuals with mental illness in cognitive behavioral group therapy for recovery of self-esteem (CBGTRS) resulted in improved outcomes. This was a non-randomized controlled trial. The participants were persons with mental illness who resided in communities in the Chugoku region of Japan. In total, 41 were assigned to an experimental group (CBGTRS intervention, 12 group sessions), and 21 to a control group. Outcome indices (self-esteem, moods, cognition, subjective well-being, psychiatric symptoms) were measured for the experimental group prior to intervention (T0), immediately post-intervention (T1), and at 3 (T2) and 12 (T3) months post-intervention. The control group was measured at the same intervals. For the experimental group, self-esteem scores at T1, T2, and T3 were significantly higher than at T0. Moods and cognition scores remained significantly low until T2. Scores for Inadequate Mental Mastery in the subjective well-being index had not decreased by T3. Confidence in Coping remained significantly high until T2. Psychiatric symptoms scores at T0, T1, T2, and T3 were significantly lower than at T0. The means and standard errors for self-esteem and Inadequate Mental Mastery increased until T3, and those for Tension-Anxiety, Depression-Dejection, and Confusion decreased until T2. From within-group trends and between-group differences in self-esteem, we conclude that CBGTRS may have a relatively long-term effect on self-esteem recovery. T2 is the turning point for moods and cognition; thus, follow-up is needed 3 months following the initial program. © 2016 The Authors. Psychiatry and Clinical Neurosciences © 2016 Japanese Society of Psychiatry and Neurology.

  9. Non-random temporary emigration and the robust design: Conditions for bias at the end of a time series: Section VIII

    Science.gov (United States)

    Langtimm, Catherine A.

    2008-01-01

    Deviations from model assumptions in the application of capture–recapture models to real life situations can introduce unknown bias. Understanding the type and magnitude of bias under these conditions is important to interpreting model results. In a robust design analysis of long-term photo-documented sighting histories of the endangered Florida manatee, I found high survival rates, high rates of non-random temporary emigration, significant time-dependence, and a diversity of factors affecting temporary emigration that made it difficult to model emigration in any meaningful fashion. Examination of the time-dependent survival estimates indicated a suspicious drop in survival rates near the end of the time series that persisted when the original capture histories were truncated and reanalyzed under a shorter time frame. Given the wide swings in manatee emigration estimates from year to year, a likely source of bias in survival was the convention to resolve confounding of the last survival probability in a time-dependent model with the last emigration probabilities by setting the last unmeasurable emigration probability equal to the previous year’s probability when the equality was actually false. Results of a series of simulations demonstrated that if the unmeasurable temporary emigration probabilities in the last time period were not accurately modeled, an estimation model with significant annual variation in survival probabilities and emigration probabilities produced bias in survival estimates at the end of the study or time series being explored. Furthermore, the bias propagated back in time beyond the last two time periods and the number of years affected varied positively with survival and emigration probabilities. Truncating the data to a shorter time frame and reanalyzing demonstrated that with additional years of data surviving temporary emigrants eventually return and are detected, thus in subsequent analysis unbiased estimates are eventually realized.

  10. Rock magnetic evidence of non-random raw material selection criteria in Cerro Toledo Obsidian Artifacts from Valles Caldera, New Mexico

    Science.gov (United States)

    Gregovich, A.; Feinberg, J. M.; Steffen, A.; Sternberg, R. S.

    2014-12-01

    Stone tools are one of the most enduring forms of ancient human behavior available to anthropologists. The geologic materials that comprise stone tools are a reflection of the rocks that were available locally or through trade, as are the intended use of the tools and the knapping technology needed to produce them. Investigation of the rock magnetic and geochemical characteristics of the artifacts and the geological source materials provides a baseline to explore these past behaviors. This study uses rock magnetic properties to explore the raw material selection criteria involved in the production of obsidian tools in the region around Valles Caldera in northern New Mexico. Obsidian is locally abundant and was traded by tribes across the central United States. Here we compare the rock magnetic properties of a sample of obsidian projectile points (N =25) that have been geochemically sourced to the Cerro Toledo obsidian flow with geological samples collected from four sites within the same flow (N =135). This collection of archaeological artifacts, albeit small, contains representatives of at least 8 different point styles that were used over 6000 years from the Archaic into the Late Prehistoric. Bulk rock hysteresis parameters (Mr, Ms, Bc, and Bcr) and low-field susceptibility (Χ) measurements show that the projectile points generally contain a lower concentration of magnetic minerals than the geologic samples. For example, the artifacts' median Ms value is 2.9 x 10-3 Am2kg-1, while that of the geological samples is 6.5 x 10-3 Am2kg-1. The concentration of magnetic minerals in obsidian is a proxy for the concentration of microlites in general, and this relationship suggests that although obsidian was locally abundant, toolmakers employed non-random selection criteria resulting in generally lower concentrations of microlites in their obsidian tools.

  11. Spiritual Care Therapy on Quality of Life in Cancer Patients and Their Caregivers: A Prospective Non-randomized Single-Cohort Study.

    Science.gov (United States)

    Sankhe, A; Dalal, K; Agarwal, V; Sarve, P

    2017-04-01

    Spiritual care is still in infancy stage all over the globe including India. The present study was an original study evaluating the role of spiritual care in cancer patients and their primary caregivers regarding their spiritual and general well-being. The study was a prospective, non-randomized single-group study involving cancer patients undergoing surgery and their primary caregivers. Functional assessment of cancer therapy-general and functional assessment of chronic illness therapy-spiritual care was evaluated during the admission and at the time of discharge, two, four  and 6 months following discharge from the hospital. Descriptive statistics was used for demographic details and repeated measure ANOVA with Dunn's test was used for analysis of changes in the scores. A total of 107 (63 males and 44 females) patients with a mean (SD) of age 51 (13) years were recruited in the study. Similarly, for each patient one of their primary caregivers was recruited with their mean (SD) age of 39.4 (12.7) years. A total of 11/107 (10.3%) patients died and nine out of 107 (8.4%) were lost to follow-up eventually during the study period. There was a statistically significant (P spiritual care on the basis of MATCH guideline improved the level of not only spiritual well-being but general well-being also in both the patients and their primary caregivers. Control group could have improved scientific validity of study in accessing effect of spiritual care. Authors believe that more robust comparative study on each principle against all five MATCH principles in future will add scientific validity and clear the various ambiguities in spiritual care.

  12. Brachytherapy versus radical hysterectomy after external beam chemoradiation: a non-randomized matched comparison in IB2-IIB cervical cancer patients

    Directory of Open Access Journals (Sweden)

    Flores Vladimir

    2009-02-01

    Full Text Available Abstract Background A current paradigm in the treatment of cervical cancer with radiation therapy is that intracavitary brachytherapy is an essential component of radical treatment. This is a matched retrospective comparison of the results of treatment in patients treated with external beam chemoradiation (EBRT-CT and radical hysterectomy versus those treated with identical chemoradiation followed by brachytherapy. Methods In this non-randomized comparison EBRT-CT protocol was the same in both groups of 40 patients. In the standard treated patients, EBRT-CT was followed by one or two intracavitary Cesium (low-dose rate applications within 2 weeks of finishing external radiation to reach a point A dose of at least 85 Gy. In the surgically treated patients, radical hysterectomy with bilateral pelvic lymph node dissection and para-aortic lymph node sampling were performed within 7 weeks after EBRT-CT. Response, toxicity and survival were evaluated. Results A total of 80 patients were analyzed. The patients receiving EBRT-CT and surgery were matched with the standard treated cases. There were no differences in the clinicopathological characteristics between groups or in the delivery of EBRT-CT. The pattern of acute and late toxicity differed. Standard treated patients had more chronic proctitis while the surgically treated had acute complications of surgery and hydronephrosis. At a maximum follow-up of 60 months, median follow-up 26 (2–31 and 22 (3–27 months for the surgery and standard therapy respectively, eight patients per group have recurred and died. The progression free and overall survival are the same in both groups. Conclusion The results of this study suggest that radical hysterectomy can be used after EBRT-CT without compromising survival in FIGO stage IB2-IIB cervical cancer patients in settings were brachytherapy is not available. A randomized study is needed to uncover the value of surgery after EBRT-CT.

  13. A prospective, non-randomized phase II trial of Trastuzumab and Capecitabine in patients with HER2 expressing metastasized pancreatic cancer

    Directory of Open Access Journals (Sweden)

    Endlicher Esther

    2009-01-01

    Full Text Available Abstract Background Pancreatic cancer is the fourth most common cause of cancer related death in Western countries. Advantages in surgical techniques, radiation and chemotherapy had almost no impact on the long term survival of affected patients. Therefore, the need for better treatment strategies is urgent. HER2, a receptor tyrosine kinase of the EGFR family, involved in signal transduction pathways leading to cell growth and differentiation is overexpressed in a number of cancers, including breast and pancreatic cancer. While in breast cancer HER2 has already been successfully used as a treatment target, there are only limited data evaluating the effects of inhibiting HER2 tyrosine kinases in patients with pancreatic cancer. Methods Here we report the design of a prospective, non-randomized multi-centered Phase II clinical study evaluating the effects of the Fluoropyrimidine-carbamate Capecitabine (Xeloda ® and the monoclonal anti-HER2 antibody Trastuzumab (Herceptin® in patients with non-resectable, HER2 overexpressing pancreatic cancer. Patients eligible for the study will receive Trastuzumab infusions on day 1, 8 and 15 concomitant to the oral intake of Capecitabine from day 1 to day 14 of each three week cylce. Cycles will be repeated until tumor progression. A total of 37 patients will be enrolled with an interim analysis after 23 patients. Discussion Primary end point of the study is to determine the progression free survival after 12 weeks of bimodal treatment with the chemotherapeutic agent Capecitabine and the anti-HER2 antibody Trastuzumab. Secondary end points include patient's survival, toxicity analysis, quality of life, the correlation of HER2 overexpression and clinical response to Trastuzumab treatment and, finally, the correlation of CA19-9 plasma levels and progression free intervals.

  14. Two-stage revision surgery with preformed spacers and cementless implants for septic hip arthritis: a prospective, non-randomized cohort study

    Directory of Open Access Journals (Sweden)

    Logoluso Nicola

    2011-05-01

    Full Text Available Abstract Background Outcome data on two-stage revision surgery for deep infection after septic hip arthritis are limited and inconsistent. This study presents the medium-term results of a new, standardized two-stage arthroplasty with preformed hip spacers and cementless implants in a consecutive series of adult patients with septic arthritis of the hip treated according to a same protocol. Methods Nineteen patients (20 hips were enrolled in this prospective, non-randomized cohort study between 2000 and 2008. The first stage comprised femoral head resection, debridement, and insertion of a preformed, commercially available, antibiotic-loaded cement hip spacer. After eradication of infection, a cementless total hip arthroplasty was implanted in the second stage. Patients were assessed for infection recurrence, pain (visual analog scale [VAS] and hip joint function (Harris Hip score. Results The mean time between first diagnosis of infection and revision surgery was 5.8 ± 9.0 months; the average duration of follow up was 56.6 (range, 24 - 104 months; all 20 hips were successfully converted to prosthesis an average 22 ± 5.1 weeks after spacer implantation. Reinfection after total hip joint replacement occurred in 1 patient. The mean VAS pain score improved from 48 (range, 35 - 84 pre-operatively to 18 (range, 0 - 38 prior to spacer removal and to 8 (range, 0 - 15 at the last follow-up assessment after prosthesis implantation. The average Harris Hip score improved from 27.5 before surgery to 61.8 between the two stages to 92.3 at the final follow-up assessment. Conclusions Satisfactory outcomes can be obtained with two-stage revision hip arthroplasty using preformed spacers and cementless implants for prosthetic hip joint infections of various etiologies.

  15. Determining spatio-temporal distribution of bee forage species of Al-Baha region based on ground inventorying supported with GIS applications and Remote Sensed Satellite Image analysis.

    Science.gov (United States)

    Adgaba, Nuru; Alghamdi, Ahmed; Sammoud, Rachid; Shenkute, Awraris; Tadesse, Yilma; Ansari, Mahammad J; Sharma, Deepak; Hepburn, Colleen

    2017-07-01

    In arid zones, the shortage of bee forage is critical and usually compels beekeepers to move their colonies in search of better forages. Identifying and mapping the spatiotemporal distribution of the bee forages over given area is important for better management of bee colonies. In this study honey bee plants in the target areas were inventoried following, ground inventory work supported with GIS applications. The study was conducted on 85 large plots of 50 × 50 m each. At each plot, data on species name, height, base diameter, crown height, crown diameter has been taken for each plant with their respective geographical positions. The data were stored, and processed using Trimble GPS supported with ArcGIS10 software program. The data were used to estimate the relative frequency, density, abundance and species diversity, species important value index and apicultural value of the species. In addition, Remotely Sensed Satellite Image of the area was obtained and processed using Hopfield Artificial Neural Network techniques. During the study, 182 species from 49 plant families were identified as bee forages of the target area. From the total number of species; shrubs, herbs and trees were accounting for 61%, 27.67%, and 11.53% respectively. Of which Ziziphus spina-christi, Acacia tortilis, Acacia origina, Acacia asak, Lavandula dentata, and Hypoestes forskaolii were the major nectar source plants of the area in their degree of importance. The average vegetation cover values of the study areas were low (place. The Remote Sensed Satellite Image analysis confirmed the spatial distribution of the bee forage resources as determined by the ground inventory work. An integrated approach, combining the ground inventory work with GIS and satellite image processing techniques could be an important tool for characterizing and mapping the available bee forage resources leading to their efficient and sustainable utilization.

  16. 过程信息集成的分布式支撑平台%Distributed Support Foundation of Process Information Integration

    Institute of Scientific and Technical Information of China (English)

    李敏

    2000-01-01

    The object of process information integration and typical application are summarized. Based on analyzing the task of integrated foundation and at present foundation, a kind of process information distributed support foundation that mixed together the distributed component object technique, n-tiers C/S and traditional Internet is put forward. Finally, the application of this foundation in certain petroleum refinery is introduced.%首先概述了过程信息集成的目标和目前对过程信息的典型应用,然后在分析了集成平台的任务和现有平台的基础上,提出了一种融合了分布式构件对象技术、n-tiers C/S和传统Intranet的过程信息分布式支撑平台,最后介绍了该平台在某炼油企业的应用。

  17. New records and distribution modeling of Gryne orensis (Sørensen) (Opiliones: Cosmetidae) support the Mesopotamian-Yungas disjunction in subtropical Argentina.

    Science.gov (United States)

    Acosta, Luis E; Vergara, Julia

    2013-11-12

    The presence of Gryne orensis (Sørensen) (Opiliones: Cosmetidae) in a Yungas locality (northwestern Argentina) is reported for the first time, providing new evidence for the Mesopotamian-Yungas disjunct pattern. Combining a total of 19 new Mesopotamian records with previous, reliable citations from the literature, a dataset of 45 points was used to model the potential distribution of the species, using the presence-only methods BIOCLIM and MAXENT. Models supported the existence of a distributional gap across the Semiarid Chaco. The imprecise literature record from "El Impenetrable", province of Chaco, is assigned to three tentative locations to evaluate if models are affected by their inclusion; in all cases, the disjunction was maintained. It was thereby estimated that the actual record might have originated in a site closer to the Humid Chaco and/or associated to streams. This paper also provides a statement of the bioclimatic profile and identification of major environmental constraints that define the range of G. orensis. 

  18. Effect of type of luting agents on stress distribution in the bone surrounding implants supporting a three-unit fixed dental prosthesis: 3D finite element analysis.

    Science.gov (United States)

    Ghasemi, Ehsan; Abedian, Alireza; Iranmanesh, Pedram; Khazaei, Saber

    2015-01-01

    Osseointegration of dental implants is influenced by many biomechanical factors that may be related to stress distribution. The aim of this study was to evaluate the effect of type of luting agent on stress distribution in the bone surrounding implants, which support a three-unit fixed dental prosthesis (FDP) using finite element (FE) analysis. A 3D FE model of a three-unit FDP was designed replacing the maxillary first molar with maxillary second premolar and second molar as the abutments using CATIA V5R18 software and analyzed with ABAQUS/CAE 6.6 version. The model was consisted of 465108 nodes and 86296 elements and the luting agent thickness was considered 25 μm. Three load conditions were applied on eight points in each functional cusp in horizontal (57.0 N), vertical (200.0 N) and oblique (400.0 N, θ = 120°) directions. Five different luting agents were evaluated. All materials were assumed to be linear elastic, homogeneous, time independent and isotropic. For all luting agent types, the stress distribution pattern in the cortical bone, connectors, implant and abutment regions was almost uniform among the three loads. Furthermore, the maximum von Mises stress of the cortical bone was at the palatal side of second premolar. Likewise, the maximum von Mises stress in the connector region was in the top and bottom of this part. Luting agents transfer the load to cortical bone and different types of luting agents do not affect the pattern of load transfer.

  19. Effect of type of luting agents on stress distribution in the bone surrounding implants supporting a three-unit fixed dental prosthesis: 3D finite element analysis

    Science.gov (United States)

    Ghasemi, Ehsan; Abedian, Alireza; Iranmanesh, Pedram; Khazaei, Saber

    2015-01-01

    Background: Osseointegration of dental implants is influenced by many biomechanical factors that may be related to stress distribution. The aim of this study was to evaluate the effect of type of luting agent on stress distribution in the bone surrounding implants, which support a three-unit fixed dental prosthesis (FDP) using finite element (FE) analysis. Materials and Methods: A 3D FE model of a three-unit FDP was designed replacing the maxillary first molar with maxillary second premolar and second molar as the abutments using CATIA V5R18 software and analyzed with ABAQUS/CAE 6.6 version. The model was consisted of 465108 nodes and 86296 elements and the luting agent thickness was considered 25 μm. Three load conditions were applied on eight points in each functional cusp in horizontal (57.0 N), vertical (200.0 N) and oblique (400.0 N, θ = 120°) directions. Five different luting agents were evaluated. All materials were assumed to be linear elastic, homogeneous, time independent and isotropic. Results: For all luting agent types, the stress distribution pattern in the cortical bone, connectors, implant and abutment regions was almost uniform among the three loads. Furthermore, the maximum von Mises stress of the cortical bone was at the palatal side of second premolar. Likewise, the maximum von Mises stress in the connector region was in the top and bottom of this part. Conclusion: Luting agents transfer the load to cortical bone and different types of luting agents do not affect the pattern of load transfer. PMID:25709676

  20. Efficacy of adding a supporting implant in stress distribution of long-span fixed partial dentures: a 3D finite element analysis

    Science.gov (United States)

    Shurbaji Mozayek, Rami; Allaf, Mirza; B. Abuharb, Mohammad

    2016-01-01

    Background. Long span is seen in many clinical situations. Treatmentplanning options of these cases are difficult and may require FPD, RPD or ISP. Each option has its own disadvantages, including mechanical problems, patient comfort and cost. This article will evaluate the stress distribution of a different treatment option, which consists of adding a single sup-porting implant to the FPD by using 3D finite element analysis. Methods. Three models, each consisting of 5 units, were created as follows: 1. Tooth Pontic Pontic Pontic Tooth; 2. Tooth Pontic Implant Pontic Tooth; 3. Tooth Pontic Pontic Implant Tooth. An axial force was applied to the prostheses by using 3D finite element method and stresses were evaluated. Results. The maximum stress was found in the prostheses in all the models; the highest stress values in all the shared components of the models were almost similar. Stress in implants was lower in the second model than the third one. Conclusion. Adding a supporting implant in long-span FPD has no advantages while it has the disadvantages of complicating treatment and the complications that may occur to the implant and surrounding bone. PMID:27429723

  1. Ethylene homo- and copolymerization chain-transfers: A perspective from supported (nBuCp)2ZrCl2 catalyst active centre distribution

    Indian Academy of Sciences (India)

    Muhammad Atiqullah; Mamdouh A Al-Harthi; Siripon Anantawaraskul; Abdul-hamid M Emwas

    2015-04-01

    Polymerization chain termination reactions and unsaturation of the polymer backbone end are related. Therefore, in this study, the parameters resulting from the modelling of the active centre distribution of the supported catalyst—silica/MAO/(nBuCp)2ZrCl2—were applied to evaluate the active-centredependent ethylene homo- and copolymerization rates, as well as the corresponding chain termination rates. This approach, from a microkinetic mechanistic viewpoint, elucidates better the 1-hexene-induced positive comonomer effect and chain transfer phenomenon. The kinetic expressions, developed on the basis of the proposed polymerization mechanisms, illustrate how the active site type-dependent chain transfer phenomenon is influenced by the different apparent termination rate constants and momoner concentrations. The active centrespecific molecular weight Mni (for the above homo- and copolymer), as a function of chain transfer probability, pCTi, varied as follows: log(pCTi) = log(mwru)−log(Mni) where mwru is the molecular weight of the repeat unit. The physical significance of this finding has been explained. The homo- and copolymer backbones showed all the three chain end unsaturations (vinyl, vinylidene, and trans-vinylene). The postulated polymerization mechanisms reveal the underlying polymer chemistry. The results of the present study will contribute to develop in future supported metallocene catalysts that will be useful to synthesize polyethylene precursors having varying chain end unsaturations, which can be eventually used to prepare functional polyethylenes.

  2. The neolithic demographic transition in Europe: correlation with juvenility index supports interpretation of the summed calibrated radiocarbon date probability distribution (SCDPD as a valid demographic proxy.

    Directory of Open Access Journals (Sweden)

    Sean S Downey

    Full Text Available Analysis of the proportion of immature skeletons recovered from European prehistoric cemeteries has shown that the transition to agriculture after 9000 BP triggered a long-term increase in human fertility. Here we compare the largest analysis of European cemeteries to date with an independent line of evidence, the summed calibrated date probability distribution of radiocarbon dates (SCDPD from archaeological sites. Our cemetery reanalysis confirms increased growth rates after the introduction of agriculture; the radiocarbon analysis also shows this pattern, and a significant correlation between both lines of evidence confirms the demographic validity of SCDPDs. We analyze the areal extent of Neolithic enclosures and demographic data from ethnographically known farming and foraging societies and we estimate differences in population levels at individual sites. We find little effect on the overall shape and precision of the SCDPD and we observe a small increase in the correlation with the cemetery trends. The SCDPD analysis supports the hypothesis that the transition to agriculture dramatically increased demographic growth, but it was followed within centuries by a general pattern of collapse even after accounting for higher settlement densities during the Neolithic. The study supports the unique contribution of SCDPDs as a valid demographic proxy for the demographic patterns associated with early agriculture.

  3. Evaluation of an advanced pressure ulcer management protocol followed by trained wound, ostomy, and continence nurses: a non-randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Kaitani T

    2015-02-01

    Full Text Available Toshiko Kaitani,1 Gojiro Nakagami,2 Junko Sugama,3 Masahiro Tachi,4 Yutaka Matsuyama,5 Yoshiki Miyachi,6 Takashi Nagase,2 Yukie Takemura,7 Hiromi Sanada2 1School of Nursing, Sapporo City University, Hokkaido, Japan; 2Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; 3Department of Clinical Nursing, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan; 4Department of Plastic Surgery, Tohoku University Graduate School of Medicine, Miyagi, Japan; 5Department of Biostatistics, School of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; 6Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; 7Department of Nursing, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan Aims and objectives: We investigated the effectiveness and safety of an advanced pressure ulcer (PU management protocol comprising 1 ultrasonography to assess the deep tissue, 2 use of a non-contact thermometer to detect critical colonization, 3 conservative sharp debridement, 4 dressing selection, 5 negative pressure wound therapy, and 6 vibration therapy in comparison with those of a conventional approach. Each protocol was followed by trained wound, ostomy, and continence nurses (WOCNs. Background: At present, there is no systematic PU management protocol for nurses that includes appropriate assessment and intervention techniques for deep tissue injury and critical colonization. In Japan, there is no such protocol that the nurses can follow without a physician’s orders. Design and methods: This was a prospective non-randomized controlled trial. Over a 3-week period, we evaluated the effectiveness of an advanced protocol by comparing the PU severity and healing on the basis of the DESIGN-R scale and presence of patients' discomfort. We recruited ten WOCNs to follow

  4. TP53 status and taxane-platinum versus platinum-based therapy in ovarian cancer patients: A non-randomized retrospective study

    Directory of Open Access Journals (Sweden)

    Markowska Janina

    2008-01-01

    Full Text Available Abstract Background Taxane-platinum therapy (TP has replaced platinum-based therapy (PC or PAC, DNA damaging chemotherapy in the postoperative treatment of ovarian cancer patients; however, it is not always effective. TP53 protein plays a differential role in response to DNA-damaging agents and taxanes. We sought to define profiles of patients who benefit the most from TP and also of those who can be treated with PC. Methods We compared the effectiveness of PC/PAC (n = 253 and TP (n = 199 with respect to tumor TP53 accumulation in ovarian cancer patients with FIGO stage IIB-IV disease; this was a non-randomized retrospective study. Immunohistochemical analysis was performed on 452 archival tumors; univariate and multivariate analysis by the Cox's and logistic regression models was performed in all patients and in subgroups with [TP53(+] and without TP53 accumulation [TP53(-]. Results The advantage of taxane-platinum therapy over platinum-based therapy was seen in the TP53(+, and not in the TP53(- group. In the TP53(+ group taxane-platinum therapy enhanced the probability of complete remission (p = .018, platinum sensitivity (p = .014, platinum highly sensitive response (p = .038 and longer survival (OS, p = .008. Poor tumor differentiation diminished the advantage from taxane-platinum therapy in the TP53(+ group. In the TP53(- group PC/PAC was at least equally efficient as taxane-platinum therapy and it enhanced the chance of platinum highly sensitive response (p = .010. However, in the TP53(- group taxane-platinum therapy possibly diminished the risk of death in patients over 53 yrs (p = .077. Among factors that positively interacted with taxane-platinum therapy in some analyses were endometrioid and clear cell type, FIGO III stage, bulky residual tumor, more advanced age of patient and moderate tumor differentiation. Conclusion Our results suggest that taxane-platinum therapy is particularly justified in patients with TP53(+ tumors or older

  5. Distribution and abundance of small plastic debris on beaches in the SE Pacific (Chile): a study supported by a citizen science project.

    Science.gov (United States)

    Hidalgo-Ruz, Valeria; Thiel, Martin

    2013-01-01

    The accumulation of large and small plastic debris is a problem throughout the world's oceans and coastlines. Abundances and types of small plastic debris have only been reported for some isolated beaches in the SE Pacific, but these data are insufficient to evaluate the situation in this region. The citizen science project "National Sampling of Small Plastic Debris" was supported by schoolchildren from all over Chile who documented the distribution and abundance of small plastic debris on Chilean beaches. Thirty-nine schools and nearly 1000 students from continental Chile and Easter Island participated in the activity. To validate the data obtained by the students, all samples were recounted in the laboratory. The results of the present study showed that the students were able to follow the instructions and generate reliable data. The average abundance obtained was 27 small plastic pieces per m(2) for the continental coast of Chile, but the samples from Easter Island had extraordinarily higher abundances (>800 items per m(2)). The abundance of small plastic debris on the continental coast could be associated with coastal urban centers and their economic activities. The high abundance found on Easter Island can be explained mainly by the transport of plastic debris via the surface currents in the South Pacific Subtropical Gyre, resulting in the accumulation of small plastic debris on the beaches of the island. This first report of the widespread distribution and abundance of small plastic debris on Chilean beaches underscores the need to extend plastic debris research to ecological aspects of the problem and to improve waste management. Copyright © 2013 Elsevier Ltd. All rights reserved.

  6. Determining spatio-temporal distribution of bee forage species of Al-Baha region based on ground inventorying supported with GIS applications and Remote Sensed Satellite Image analysis

    Directory of Open Access Journals (Sweden)

    Nuru Adgaba

    2017-07-01

    Full Text Available In arid zones, the shortage of bee forage is critical and usually compels beekeepers to move their colonies in search of better forages. Identifying and mapping the spatiotemporal distribution of the bee forages over given area is important for better management of bee colonies. In this study honey bee plants in the target areas were inventoried following, ground inventory work supported with GIS applications. The study was conducted on 85 large plots of 50 × 50 m each. At each plot, data on species name, height, base diameter, crown height, crown diameter has been taken for each plant with their respective geographical positions. The data were stored, and processed using Trimble GPS supported with ArcGIS10 software program. The data were used to estimate the relative frequency, density, abundance and species diversity, species important value index and apicultural value of the species. In addition, Remotely Sensed Satellite Image of the area was obtained and processed using Hopfield Artificial Neural Network techniques. During the study, 182 species from 49 plant families were identified as bee forages of the target area. From the total number of species; shrubs, herbs and trees were accounting for 61%, 27.67%, and 11.53% respectively. Of which Ziziphus spina-christi, Acacia tortilis, Acacia origina, Acacia asak, Lavandula dentata, and Hypoestes forskaolii were the major nectar source plants of the area in their degree of importance. The average vegetation cover values of the study areas were low (<30% with low Shannon’s species diversity indices (H′ of 0.5–1.52 for different sites. Based on the eco-climatological factors and the variations in their flowering period, these major bee forage species were found to form eight distinct spatiotemporal categories which allow beekeepers to migrate their colonies to exploit the resources at different seasons and place. The Remote Sensed Satellite Image analysis confirmed the spatial

  7. A 3-year multicentre randomized controlled trial of etonogestrel- and levonorgestrel-releasing contraceptive implants, with non-randomized matched copper-intrauterine device controls.

    Science.gov (United States)

    Bahamondes, Luis; Brache, Vivian; Meirik, Olav; Ali, Moazzam; Habib, Ndema; Landoulsi, Sihem

    2015-11-01

    Is there any difference in the clinical performance of the 3-year one-rod etonogestrel (ENG)- and the 5-year two-rod levonorgestrel (LNG)-releasing contraceptive implants during 3 years of insertion, and between implant and intrauterine device (IUD) contraception, in particular complaints possibly related to hormonal contraceptives? The cumulative contraceptive effectiveness after 3 years and method continuation through 2.5 years were not significantly different between ENG and LNG implants, but both outcomes were significantly worse in the non-randomized age-matched group of IUD users than in the combined implant group. ENG- and LNG-releasing implants are safe and highly efficacious contraceptives with pregnancy rates reported to be 0.0-0.5 per 100 women-years (W-Y). No head-to-head comparative study of the two implants has been undertaken, and little information is available on comparisons of complaints of side effects of implant and copper IUD users. This was an open parallel group RCT with 1:1 allocation ratio of the ENG and the LNG implants with non-randomized control group of women choosing TCu380A IUD to address lack of reliable data on common side effects typically attributed to the use of progestogen-only contraceptives. After device(s) placement, follow-ups were at 2 weeks, 3 and 6 months, and semi-annually thereafter for 3 years or until pregnancy, removal or expulsion of the implant/IUD occurred. The study took place in family planning clinics in Brazil, Chile, Dominican Republic, Hungary, Thailand, Turkey and Zimbabwe. Women seeking long-term contraception were enlisted after an eligibility check and informed consent, and 2982 women were enrolled: 1003, 1005 and 974 in the ENG-implant, LNG-implant and IUD groups, respectively; 995, 997 and 971, respectively, were included in the per protocol analysis reported here. ENG and LNG implants each had the same 3-year cumulative pregnancy rate of 0.4 per 100 W-Y [95% confidence interval (CI) 0.1-1.4]. A weight

  8. On Barnes Beta Distributions and Applications to the Maximum Distribution of the 2D Gaussian Free Field

    Science.gov (United States)

    Ostrovsky, Dmitry

    2016-09-01

    A new family of Barnes beta distributions on (0, ∞) is introduced and its infinite divisibility, moment determinacy, scaling, and factorization properties are established. The Morris integral probability distribution is constructed from Barnes beta distributions of types (1, 0) and (2, 2), and its moment determinacy and involution invariance properties are established. For application, the maximum distributions of the 2D gaussian free field on the unit interval and circle with a non-random logarithmic potential are conjecturally related to the critical Selberg and Morris integral probability distributions, respectively, and expressed in terms of sums of Barnes beta distributions of types (1, 0) and (2, 2).

  9. Ethylene homo- and copolymerization chain-transfers: A perspective from supported (n BuCp) 2 ZrCl 2 catalyst active centre distribution

    KAUST Repository

    Atiqullah, Muhammad

    2015-04-01

    Polymerization chain termination reactions and unsaturation of the polymer backbone end are related. Therefore, in this study, the parameters resulting from the modelling of the active centre distribution of the supported catalyst - silica/MAO/(nBuCp)2ZrCl2 - were applied to evaluate the active-centre-dependent ethylene homo- and copolymerization rates, as well as the corresponding chain termination rates. This approach, from a microkinetic mechanistic viewpoint, elucidates better the 1-hexene-induced positive comonomer effect and chain transfer phenomenon. The kinetic expressions, developed on the basis of the proposed polymerization mechanisms, illustrate how the active site type-dependent chain transfer phenomenon is influenced by the different apparent termination rate constants and momoner concentrations. The active centre-specific molecular weight M ni (for the above homo- and copolymer), as a function of chain transfer probability, p CTi, varied as follows: log (p C Ti) = log (mwru) - log (Mn i), where mw ru is the molecular weight of the repeat unit. The physical significance of this finding has been explained. The homo- and copolymer backbones showed all the three chain end unsaturations (vinyl, vinylidene, and trans-vinylene). The postulated polymerization mechanisms reveal the underlying polymer chemistry. The results of the present study will contribute to develop in future supported metallocene catalysts that will be useful to synthesize polyethylene precursors having varying chain end unsaturations, which can be eventually used to prepare functional polyethylenes. [Figure not available: see fulltext.] © 2015 Indian Academy of Sciences.

  10. Integrated Logistics Support Analysis of the International Space Station Alpha, Background and Summary of Mathematical Modeling and Failure Density Distributions Pertaining to Maintenance Time Dependent Parameters

    Science.gov (United States)

    Sepehry-Fard, F.; Coulthard, Maurice H.

    1995-01-01

    The process of predicting the values of maintenance time dependent variable parameters such as mean time between failures (MTBF) over time must be one that will not in turn introduce uncontrolled deviation in the results of the ILS analysis such as life cycle costs, spares calculation, etc. A minor deviation in the values of the maintenance time dependent variable parameters such as MTBF over time will have a significant impact on the logistics resources demands, International Space Station availability and maintenance support costs. There are two types of parameters in the logistics and maintenance world: a. Fixed; b. Variable Fixed parameters, such as cost per man hour, are relatively easy to predict and forecast. These parameters normally follow a linear path and they do not change randomly. However, the variable parameters subject to the study in this report such as MTBF do not follow a linear path and they normally fall within the distribution curves which are discussed in this publication. The very challenging task then becomes the utilization of statistical techniques to accurately forecast the future non-linear time dependent variable arisings and events with a high confidence level. This, in turn, shall translate in tremendous cost savings and improved availability all around.

  11. Integrated Logistics Support Analysis of the International Space Station Alpha, Background and Summary of Mathematical Modeling and Failure Density Distributions Pertaining to Maintenance Time Dependent Parameters

    Science.gov (United States)

    Sepehry-Fard, F.; Coulthard, Maurice H.

    1995-01-01

    The process of predicting the values of maintenance time dependent variable parameters such as mean time between failures (MTBF) over time must be one that will not in turn introduce uncontrolled deviation in the results of the ILS analysis such as life cycle costs, spares calculation, etc. A minor deviation in the values of the maintenance time dependent variable parameters such as MTBF over time will have a significant impact on the logistics resources demands, International Space Station availability and maintenance support costs. There are two types of parameters in the logistics and maintenance world: a. Fixed; b. Variable Fixed parameters, such as cost per man hour, are relatively easy to predict and forecast. These parameters normally follow a linear path and they do not change randomly. However, the variable parameters subject to the study in this report such as MTBF do not follow a linear path and they normally fall within the distribution curves which are discussed in this publication. The very challenging task then becomes the utilization of statistical techniques to accurately forecast the future non-linear time dependent variable arisings and events with a high confidence level. This, in turn, shall translate in tremendous cost savings and improved availability all around.

  12. Effect of post-stroke sensory disorders on the recovery processes of motor function and activity of daily living A non-randomized synchroniesl controlled trial

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    BACKGROUND:In the rehabilitation of stroke patients,clinicians usually concentrate on motor problems,such as spasm of limbs and restriction of joint motion,while sensory and perceptive problems are almost always neglected,although they are just as important.One such area is the sensory disorder. OBJECTIVE:To evaluate the motor function and activities of daily living in stroke patients with and without sensory disorders after treatment of integrated western and Chinese medicine.DESIGN:A non-randomized synchronically controlled trial.SETTING:First Affiliated Hospital of Tianjin College of Traditional Chinese Medicine.PARTICIPANTS:Totally 500 stroke inpatients were selected from the Department of Acupuncture and Massage,the First Affiliated Hospital of Tianjin College of Traditional Chinese Medicine from January 2003 to December 2004.They all had suffered from stroke in the last 4 weeks and accompanied by sensory disorder of the ipsilateral limb to different severity.The patients were all accorded with the Diagnostic and Efficacy Evaluative Standards for Stroke (in trial)set by the Encephalopathy Emergency Assistant Group,the State Administration of Traditional Chinese Medicine in 1995,and they were diagnosed by imaging examination.The patients were stratified into sensory disorder group (n =220) and normal sense group (n=280).Informed consent for the detected items and therapeutic program was obtained from the relatives of all the participants.The study was approved by the hospital ethical committee.METHODS:All the patients were treated with acupuncture of Xing Nao Kai Qiao for restoring consciousness and inducing resuscitation,assisted by traditional Chinese medicine and western medicine specific to corresponding symptoms.The therapeutic principles were restoring consciousness and inducing resuscitation,nourishing liver and kidney,and dredging meridian.In addition,the patients were given western medical treatments for decreasing intracranial pressure

  13. Towards a Scalable and Adaptive Application Support Platform for Large-Scale Distributed E-Sciences in High-Performance Network Environments

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Chase Qishi [New Jersey Inst. of Technology, Newark, NJ (United States); Univ. of Memphis, TN (United States); Zhu, Michelle Mengxia [Southern Illinois Univ., Carbondale, IL (United States)

    2016-06-06

    The advent of large-scale collaborative scientific applications has demonstrated the potential for broad scientific communities to pool globally distributed resources to produce unprecedented data acquisition, movement, and analysis. System resources including supercomputers, data repositories, computing facilities, network infrastructures, storage systems, and display devices have been increasingly deployed at national laboratories and academic institutes. These resources are typically shared by large communities of users over Internet or dedicated networks and hence exhibit an inherent dynamic nature in their availability, accessibility, capacity, and stability. Scientific applications using either experimental facilities or computation-based simulations with various physical, chemical, climatic, and biological models feature diverse scientific workflows as simple as linear pipelines or as complex as a directed acyclic graphs, which must be executed and supported over wide-area networks with massively distributed resources. Application users oftentimes need to manually configure their computing tasks over networks in an ad hoc manner, hence significantly limiting the productivity of scientists and constraining the utilization of resources. The success of these large-scale distributed applications requires a highly adaptive and massively scalable workflow platform that provides automated and optimized computing and networking services. This project is to design and develop a generic Scientific Workflow Automation and Management Platform (SWAMP), which contains a web-based user interface specially tailored for a target application, a set of user libraries, and several easy-to-use computing and networking toolkits for application scientists to conveniently assemble, execute, monitor, and control complex computing workflows in heterogeneous high-performance network environments. SWAMP will enable the automation and management of the entire process of scientific

  14. Towards a Scalable and Adaptive Application Support Platform for Large-Scale Distributed E-Sciences in High-Performance Network Environments

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Chase Qishi [New Jersey Inst. of Technology, Newark, NJ (United States); Univ. of Memphis, TN (United States); Zhu, Michelle Mengxia [Southern Illinois Univ., Carbondale, IL (United States)

    2016-06-06

    The advent of large-scale collaborative scientific applications has demonstrated the potential for broad scientific communities to pool globally distributed resources to produce unprecedented data acquisition, movement, and analysis. System resources including supercomputers, data repositories, computing facilities, network infrastructures, storage systems, and display devices have been increasingly deployed at national laboratories and academic institutes. These resources are typically shared by large communities of users over Internet or dedicated networks and hence exhibit an inherent dynamic nature in their availability, accessibility, capacity, and stability. Scientific applications using either experimental facilities or computation-based simulations with various physical, chemical, climatic, and biological models feature diverse scientific workflows as simple as linear pipelines or as complex as a directed acyclic graphs, which must be executed and supported over wide-area networks with massively distributed resources. Application users oftentimes need to manually configure their computing tasks over networks in an ad hoc manner, hence significantly limiting the productivity of scientists and constraining the utilization of resources. The success of these large-scale distributed applications requires a highly adaptive and massively scalable workflow platform that provides automated and optimized computing and networking services. This project is to design and develop a generic Scientific Workflow Automation and Management Platform (SWAMP), which contains a web-based user interface specially tailored for a target application, a set of user libraries, and several easy-to-use computing and networking toolkits for application scientists to conveniently assemble, execute, monitor, and control complex computing workflows in heterogeneous high-performance network environments. SWAMP will enable the automation and management of the entire process of scientific

  15. A systematic review and meta-analysis of randomized and non-randomized studies comparing laparoscopic and open abdominoperineal resection for rectal cancer.

    LENUS (Irish Health Repository)

    Ahmad, N Z

    2013-03-01

    Evidence supporting the role of laparoscopy in abdominoperineal resection (APR) is limited. This study compared the short-term and long-term outcomes and complications associated with open and laparoscopic APR.

  16. Data fabrication and other reasons for non-random sampling in 5087 randomised, controlled trials in anaesthetic and general medical journals.

    Science.gov (United States)

    Carlisle, J B

    2017-08-01

    Randomised, controlled trials have been retracted after publication because of data fabrication and inadequate ethical approval. Fabricated data have included baseline variables, for instance, age, height or weight. Statistical tests can determine the probability of the distribution of means, given their standard deviation and the number of participants in each group. Randomised, controlled trials have been retracted after the data distributions have been calculated as improbable. Most retracted trials have been written by anaesthetists and published by specialist anaesthetic journals. I wanted to explore whether the distribution of baseline data in trials was consistent with the expected distribution. I wanted to determine whether trials retracted after publication had distributions different to trials that have not been retracted. I wanted to determine whether data distributions in trials published in specialist anaesthetic journals have been different to distributions in non-specialist medical journals. I analysed the distribution of 72,261 means of 29,789 variables in 5087 randomised, controlled trials published in eight journals between January 2000 and December 2015: Anaesthesia (399); Anesthesia and Analgesia (1288); Anesthesiology (541); British Journal of Anaesthesia (618); Canadian Journal of Anesthesia (384); European Journal of Anaesthesiology (404); Journal of the American Medical Association (518) and New England Journal of Medicine (935). I chose these journals as I had electronic access to the full text. Trial p values were distorted by an excess of baseline means that were similar and an excess that were dissimilar: 763/5015 (15.2%) trials that had not been retracted from publication had p values that were within 0.05 of 0 or 1 (expected 10%), that is, a 5.2% excess, p = 1.2 × 10(-7) . The p values of 31/72 (43%) trials that had been retracted after publication were within 0.05 of 0 or 1, a rate different to that for unretracted trials, p = 1.03

  17. Protein kinase Cα and Src kinase support human prostate-distributed dihydrotestosterone-metabolizing UDP-glucuronosyltransferase 2B15 activity.

    Science.gov (United States)

    Chakraborty, Sunit K; Basu, Nikhil K; Jana, Sirsendu; Basu, Mousumi; Raychoudhuri, Amit; Owens, Ida S

    2012-07-13

    Because human prostate-distributed UDP-glucuronosyltransferase (UGT) 2B15 metabolizes 5α-dihydrotestosterone (DHT) and 3α-androstane-5α,17β-diol metabolite, we sought to determine whether 2B15 requires regulated phosphorylation similar to UGTs already analyzed. Reversible down-regulation of 2B15-transfected COS-1 cells following curcumin treatment and irreversible inhibition by calphostin C, bisindolylmaleimide, or röttlerin treatment versus activation by phorbol 12-myristate 13-acetate indicated that 2B15 undergoes PKC phosphorylation. Mutation of three predicted PKC and two tyrosine kinase sites in 2B15 caused 70-100 and 80-90% inactivation, respectively. Anti-UGT-1168 antibody trapped 2B15-His-containing co-immunoprecipitates of PKCα in 130-140- and >150-kDa complexes by gradient SDS-PAGE analysis. Complexes bound to WT 2B15-His remained intact during electrophoresis, whereas 2B15-His mutants at phosphorylation sites differentially dissociated. PKCα siRNA treatment inactivated >50% of COS-1 cell-expressed 2B15. In contrast, treatment of 2B15-transfected COS-1 cells with the Src-specific activator 1,25-dihydroxyvitamin D(3) enhanced activity; treatment with the Src-specific PP2 inhibitor or Src siRNA inhibited >50% of the activity. Solubilized 2B15-His-transfected Src-free fibroblasts subjected to in vitro [γ-(33)P]ATP-dependent phosphorylation by PKCα and/or Src, affinity purification, and SDS gel analysis revealed 2-fold more radiolabeling of 55-58-kDa 2B15-His by PKCα than by Src; labeling was additive for combined kinases. Collectively, the evidence indicates that 2B15 requires regulated phosphorylation by both PKCα and Src, which is consistent with the complexity of synthesis and metabolism of its major substrate, DHT. Whether basal cells import or synthesize testosterone for transport to luminal cells for reduction to DHT by 5α-steroid reductase 2, comparatively low-activity luminal cell 2B15 undergoes a complex pattern of regulated

  18. Mesoporous silica supported multiple single-site catalysts and polyethylene reactor blends with tailor-made trimodal and ultra-broad molecular weight distributions.

    Science.gov (United States)

    Kurek, Alexander; Mark, Stefan; Enders, Markus; Kristen, Marc O; Mülhaupt, Rolf

    2010-08-03

    A ternary blend of the bisiminopyridine chromium (III) (Cr-1) with the bisiminopyridine iron (II) (Fe-2) post-metallocenes with the quinolylsilylcyclopentadienyl chromium (III) halfsandwich complex (Cr-3) was supported on mesoporous silica to produce novel multiple single-site catalysts and polyethylene reactor blends with tailor-made molecular weight distributions (MWDs). The preferred cosupporting sequence of this ternary blend on MAO-treated silica was Fe-2 followed by Cr-1 and Cr-3. Cosupporting does not impair the single-site nature of the blend components producing polyethylene fractions with $\\overline M _{\\rm w}$ = 10(4) g · mol(-1) on Cr-1, $\\overline M _{\\rm w}$ = 3 × 10(5) g · mol(-1) on Fe-2, and $\\overline M _{\\rm w}$ = 3 × 10(6) g · mol(-1) on Cr-3. As a function of the Fe-2/Cr-1/Cr-2 mixing ratio it is possible to control the weight ratio of these three polyethylenes without affecting the individual average molecular weights and narrow polydispersities of the three polyethylene fractions. Tailor-made polyethylene reactor blends with ultra-broad MWD and polydispersities varying between 10 and 420 were obtained. When the molar ratio of Fe-2/Cr-1 was constant, the ultra-high molecular polyethylene (UHMWPE, $\\overline M _{\\rm w}$ > 10(6) g · mol(-1) ) content was varied between 8 and 16 wt.-% as a function of the Cr-3 content without impairing the blend ratio of the other two polyethylene fractions and without sacrificing melt processability. When the molar ratio Fe-2/Cr-3 was constant, it was possible to selectively increase the content of the low molecular weight fraction by additional cosupporting of Cr-1. Due to the intimate mixing of low and ultra-high molecular weight polyethylenes (UHMPEs) produced on cosupported single-site catalysts a wide range of melt processable polyethylene reactor blends was obtained.

  19. Distributed Collaborative Learning in a Telematic Context: Telematic Learning Support and its Potential for Collaborative Learning with New Paradigms and Conceptual Mapping Tools

    NARCIS (Netherlands)

    Kommers, Petrus A.M.; van der Veer, Gerrit C.; Lenting, Bert

    1998-01-01

    CSCL (Computer Supported Co‐operative Learning), better called TSCL, Telematic (and IT) Supported Co‐operative Learning, seems to be driven by both social dynamics (like the tendency to reduce the formal training component in industrial settings, and have it replaced by training on the job, handling

  20. Does working with the Veder Contact Method influence the job satisfaction of caregivers? A non-randomized controlled trial in nursing homes for people with dementia.

    Science.gov (United States)

    Boersma, P; Dröes, R M; Lissenberg-Witte, B I; van Meijel, B; van Weert, J C M

    2017-08-22

    Person-centered care interventions can improve the quality of life and decrease behavioral problems of people with dementia. Although not convincingly proven, person-centered care interventions may benefit the caregivers as well. This study aims to gain insight into how working with the Veder Contact Method (VCM) - a new person-centered care method - influences the job satisfaction of caregivers. Within a quasi-experimental study, the job satisfaction of caregivers of six experimental wards (n = 75) was compared with caregivers of six control wards (n = 36) that applied Care-As-Usual. The Leiden Quality of Work Questionnaire (LQWQ) was filled in by caregivers in both conditions. Additionally, on the experimental wards, qualitative research, i.e. focus groups with 42 caregivers and interviews with 11 managers, was conducted to obtain a deeper understanding of the influence of applying VCM on caregivers' job satisfaction. The transcripts were analyzed using deductive analysis. No quantitatively significant differences were found on the subscales of the LQWQ: work and time pressure, job satisfaction, autonomous decision making, social support from colleagues, and social support from supervisors. From the qualitative research, some caregivers and managers reported that implementing VCM contributed to their job satisfaction and that applying VCM supported handling difficult behavior and depressed mood of residents and contributed to team building. No significant effects on job satisfaction were demonstrated. Qualitative findings indicate that VCM positively influences the daily work performances of nursing home caregivers. The relation between the experience of offering quality care and job satisfaction of caregivers needs further investigation.

  1. 基于支持向量机的配电网过电压模式识别%Overvoltage Identification in Distribution Networks Based on Support Vector Machine

    Institute of Scientific and Technical Information of China (English)

    杜林; 戴斌; 司马文霞

    2009-01-01

    The internal and external overvoltage in distribution networks is the main reason of accidents. Based on overvohage data in distribution network recorded by overvoltage on-line monitoring system, this paper analyzes the characteristics of zero sequence voltage waveform. The maximum amplitude and RMS value of zero sequence voltage, the minimum RMS of low frequency component of three phase voltage in stable range and other five parameters are selected as characteristic parameters to identify internal and external overvoltage. According to the operation data and record, all overvohage data recorded by on-line monitoring system were labeled as internal or external overvoltage and the discrimination function is constructed by support vector machine method. The test results of field acquired overvohage data indicate that the identification parameters and method based on the zero sequence voltage and support vector machine (SVM) are correct and effective.

  2. Internet-based support programs to alleviate psychosocial and physical symptoms in cancer patients : A literature analysis

    NARCIS (Netherlands)

    Bouma, Grietje; Admiraal, Lien M.; de Vries, Elisabeth G. E.; Schroder, Carolien P.; Walenkamp, Annemiek M. E.; Reyners, Anna K. L.

    2015-01-01

    In this review the effect of internet-based support programs on psychosocial and physical symptoms resulting from cancer diagnosis and treatment is analyzed. Selection of studies was based on the following criteria: (non-)randomized controlled trials, performed in adult cancer patients, comparing qu

  3. Distribution electric system simulator to support decision-making for CFE (Federal Electric Commission) Distribution Control Centers; Simulador del Sistema Electrico de Distribucion para apoyo en la toma de decisiones en Centros de Control de Distribucion de la CFE

    Energy Technology Data Exchange (ETDEWEB)

    Espinosa Reza, Alfredo; Quintero Reyes, Agustin; Garcia Mendoza, Raul; Calleros Torres, Tito Manuel [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico); Borjas Diaz, Jesus Fidel; Sierra Rodriguez, Benjamin; Torres Abrego, Rafael [Comision Federal de Electricidad (Mexico)

    2011-07-01

    This article presents the physical, logical and functional architecture designed to integrate the Electric Distribution System (EDS) simulator developed for the CFE and the electric energy Distribution Control Centers in Mexico. The objective of the EDS simulator is to integrate engineering distribution functions (power flow, short circuit, optimal reconfiguration and reliability, among others) and an expert system (Case-based Reasoning) to aid the process of information analysis, decision-making and the capacity-building of the CFE's Regional and Zonal Distribution Control Centers. The EDS simulator has been installed, updated and is operational in the Tampico Zone and the Gulf Division Distribution Center, as an established product that continually evolves along with the actual operating dynamics. [Spanish] Se presenta la arquitectura fisica, logica y funcional disenada para integrar el simulador del Sistema Electrico de Distribucion (SED) desarrollado para la Comision Federal de Electricidad (CFE) y los Centros de Control de Distribucion de energia electrica en Mexico. El objetivo del simulador del SED es integrar funciones de ingenieria de distribucion (flujo de potencia, corto circuito, reconfiguracion optima, confiabilidad, entre otras) y un sistema experto (Razonamiento Basado en Casos) para apoyar el proceso de analisis de informacion, la toma de decisiones y la capacitacion en los Centros de Control de Distribucion Zonales y Regionales de CFE. El Simulador del SED se encuentra instalado, actualizado y en operacion en la Zona Tampico y en la Division de Distribucion Golfo Centro como un producto consolidado y en constante evolucion a la par de la dinamica operativa real.

  4. Ocean Color Products Supporting the Assessment of Good Environmental Status: Development of a Spatial Distribution Model for the Seagrass Posidonia Oceanica (L.) Delille, 1813

    Science.gov (United States)

    Zucchetta, M.; Taji, M. A.; Mangin, A.; Pastres, R.

    2015-12-01

    Posidonia oceanica (L.) Delile, 1813 is a seagrass species endemic to the Mediterranean Sea, which is considered as one of the key habitats of the coastal areas. This species forms large meadows sensitive to several anthropogenic pressures, that can be regarded as indicators of environment quality in coastal environments and its distributional patterns should be take into account when evaluating the Environmental Status following the Ecosystem approach promoted by the Mediterranean Action Plan of UNEP and the EU Marine Strategy Framework Directive (2008/56/EC). The aim of this study was to develop a Species Distribution Model for P. oceanica, to be applied to the whole Mediterranean North African coast, in order to obtain an estimation of the potential distribution of this species in the region to be considered as an indicator for the assessment of good Environmental Status. As the study area is a data-poor zone with regard to seagrass distribution (i.e. only for some areas detailed distribution maps are available), the Species Distribution Model (SDM) was calibrated using high resolution data from 5 Mediterranean sites, located in Italy and Spain and validated using available data from the North African coast. Usually, when developing SDMs species occupancy data is available at coarser resolution than the information of environmental variables, and thus has to be downscaled at the appropriate grain to be coupled to the environmental conditions. Tackling the case of P. oceanica we had to face the opposite problem: the quality (in terms of resolution) of the information on seagrass distribution is generally very high compared to the environmental data available over large scale in marine domains (e.g. global bathymetry data). The high resolution application and the model transfer (from calibration areas to North African coast) was possible taking advantage of Ocean Color products: the probability of presence of the species in a given area was modelled using a

  5. Impact of specialist home-based palliative care services in a tertiary oncology set up: A prospective non-randomized observational study

    Directory of Open Access Journals (Sweden)

    Sunil R Dhiliwal

    2015-01-01

    Full Text Available Background: Home-based specialist palliative care services are developed to meet the needs of the patients in advanced stage of cancer at home with physical symptoms and distress. Specialist home care services are intended to improve symptom control and quality of life, enable patients to stay at home, and avoid unnecessary hospital admission. Materials and Methods: Total 690 new cases registered under home-based palliative care service in the year 2012 were prospectively studied to assess the impact of specialist home-based services using Edmonton symptom assessment scale (ESAS and other parameters. Results: Out of the 690 registered cases, 506 patients received home-based palliative care. 50.98% patients were cared for at home, 28.85% patients needed hospice referral and 20.15% patients needed brief period of hospitalization. All patients receiving specialist home care had good relief of physical symptoms ( P < 0.005. 83.2% patients received out of hours care (OOH through liaising with local general practitioners; 42.68% received home based bereavement care and 91.66% had good bereavement outcomes. Conclusion: Specialist home-based palliative care improved symptom control, health-related communication and psychosocial support. It promoted increased number of home-based death, appropriate and early hospice referral, and averted needless hospitalization. It improved bereavement outcomes, and caregiver satisfaction.

  6. Simulation of the K-function in the analysis of spatial clustering for non-randomly distributed locations-Exemplified by bovine virus diarrhoea virus (BVDV) infection in Denmark

    DEFF Research Database (Denmark)

    Ersbøll, Annette Kjær; Ersbøll, Bjarne Kjær

    2009-01-01

    The K-function is often used to detect spatial clustering in spatial point processes, e.g. clustering of infected herds. Clustering is identified by testing the observed K-function for complete spatial randomness modelled, e.g. by a homogeneous Poisson process. The approach provides information a...... of the herd locations in general. The approach also overcomes edge effects and problems with complex shapes of the study region. An application to bovine virus diarrhoea virus (BVDV) infection in Denmark is described....

  7. Risk of Bias in Systematic Reviews of Non-Randomized Studies of Adverse Cardiovascular Effects of Thiazolidinediones and Cyclooxygenase-2 Inhibitors: Application of a New Cochrane Risk of Bias Tool.

    Directory of Open Access Journals (Sweden)

    Anja Bilandzic

    2016-04-01

    Full Text Available Systematic reviews of the effects of healthcare interventions frequently include non-randomized studies. These are subject to confounding and a range of other biases that are seldom considered in detail when synthesizing and interpreting the results. Our aims were to assess the reliability and usability of a new Cochrane risk of bias (RoB tool for non-randomized studies of interventions and to determine whether restricting analysis to studies with low or moderate RoB made a material difference to the results of the reviews.We selected two systematic reviews of population-based, controlled non-randomized studies of the relationship between the use of thiazolidinediones (TZDs and cyclooxygenase-2 (COX-2 inhibitors and major cardiovascular events. Two epidemiologists applied the Cochrane RoB tool and made assessments across the seven specified domains of bias for each of 37 component studies. Inter-rater agreement was measured using the weighted Kappa statistic. We grouped studies according to overall RoB and performed statistical pooling for (a all studies and (b only studies with low or moderate RoB. Kappa scores across the seven bias domains ranged from 0.50 to 1.0. In the COX-2 inhibitor review, two studies had low overall RoB, 14 had moderate RoB, and five had serious RoB. In the TZD review, six studies had low RoB, four had moderate RoB, four had serious RoB, and two had critical RoB. The pooled odds ratios for myocardial infarction, heart failure, and death for rosiglitazone versus pioglitazone remained significantly elevated when analyses were confined to studies with low or moderate RoB. However, the estimate for myocardial infarction declined from 1.14 (95% CI 1.07-1.24 to 1.06 (95% CI 0.99-1.13 when analysis was confined to studies with low RoB. Estimates of pooled relative risks of cardiovascular events with COX-2 inhibitors compared with no nonsteroidal anti-inflammatory drug changed little when analyses were confined to studies with

  8. A Non-randomized Comparison of Strategies for Consultation in a Community-Academic Training Program to Implement an Evidence-Based Psychotherapy

    Science.gov (United States)

    Stirman, Shannon Wiltsey; Pontoski, Kristin; Creed, Torrey; Xhezo, Regina; Evans, Arthur C.; Beck, Aaron T.; Crits-Christoph, Paul

    2017-01-01

    Despite the central role of training and consultation in the implementation of evidence-based psychological interventions (EBPIs), comprehensive reviews of research on training have highlighted serious gaps in knowledge regarding best practices. Consultation after initial didactic training appears to be of critical importance, but there has been very little research to determine optimal consultation format or interventions. This observational study compared two consultation formats that included review of session audio and feedback in the context of a program to train clinicians (n = 85) in community mental health clinics to deliver cognitive therapy (CT). A “gold standard” condition in which clinicians received individual feedback after expert consultants reviewed full sessions was compared to a group consultation format in which short segments of session audio were reviewed by a group of clinicians and an expert consultant. After adjusting for potential baseline differences between individuals in the two consultation conditions, few differences were found in terms of successful completion of the consultation phase or in terms of competence in CT at the end of consultation or after a 2 year follow-up. However, analyses did not support hypotheses regarding non-inferiority of the group consultation condition. While both groups largely maintained competence, clinicians in the group consultation condition demonstrated increases in competence over the follow-up period, while a sub-group of those in the individual condition experienced decreases. These findings, if replicated, have important implications for EBP implementation programs, as they suggest that observation and feedback is feasible in community mental health setting, and that employing this method in a group format is an effective and efficient consultation strategy that may enhance the implementation and sustainability of evidence-based psychotherapies. PMID:26577646

  9. Processes and procedures for a worldwide biological samples distribution; product assurance and logistic activities to support the mice drawer system tissue sharing event

    Science.gov (United States)

    Benassai, Mario; Cotronei, Vittorio

    The Mice Drawer System (MDS) is a scientific payload developed by the Italian Space Agency (ASI), it hosted 6 mice on the International Space Station (ISS) and re-entered on ground on November 28, 2009 with the STS 129 at KSC. Linked to the MDS experiment, a Tissue Sharing Program (TSP), was developed in order to make available to 16 Payload Investigators (PI) (located in USA, Canada, EU -Italy, Belgium and Germany -and Japan) the biological samples coming from the mice. ALTEC SpA (a PPP owned by ASI, TAS-I and local institutions) was responsible to support the logistics aspects of the MDS samples for the first MDS mission, in the frame of Italian Space Agency (ASI) OSMA program (OSteoporosis and Muscle Atrophy). The TSP resulted in a complex scenario, as ASI, progressively, extended the original OSMA Team also to researchers from other ASI programs and from other Agencies (ESA, NASA, JAXA). The science coordination was performed by the University of Genova (UNIGE). ALTEC has managed all the logistic process with the support of a specialized freight forwarder agent during the whole shipping operation phases. ALTEC formalized all the steps from the handover of samples by the dissection Team to the packaging and shipping process in a dedicated procedure. ALTEC approached all the work in a structured way, performing: A study of the aspects connected to international shipments of biological samples. A coopera-tive work with UNIGE/ASI /PIs to identify all the needs of the various researchers and their compatibility. A complete revision and integration of shipment requirements (addresses, tem-peratures, samples, materials and so on). A complete definition of the final shipment scenario in terms of boxes, content, refrigerant and requirements. A formal approach to identification and selection of the most suited and specialized Freight Forwarder. A clear identification of all the processes from sample dissection by PI Team, sample processing, freezing, tube preparation

  10. Calculations of Compound Nucleus Spin-Parity Distributions Populated via the (p,t Reaction in Support of Surrogate Neutron Capture Measurements

    Directory of Open Access Journals (Sweden)

    Benstead J.

    2016-01-01

    Full Text Available The surrogate reaction method may be used to determine the cross section for neutron induced reactions not accessible through standard experimental techniques. This is achieved by creating the same compound nucleus as would be expected in the desired reaction, but through a different incident channel, generally a direct transfer reaction. So far, the surrogate technique has been applied with reasonable success to determine the fission cross section for a number of actinides, but has been less successful when applied to other reactions, e.g. neutron capture, due to a ‘spin-parity mismatch’. This mismatch, between the spin and parity distributions of the excited levels of the compound nucleus populated in the desired and surrogate channels, leads to differing decay probabilities and hence reduces the validity of using the surrogate method to infer the cross section in the desired channel. A greater theoretical understanding of the expected distribution of levels excited in both the desired and surrogate channels is therefore required in order to attempt to address this mismatch and allow the method to be utilised with greater confidence. Two neutron transfer reactions, e.g. (p,t, which allow the technique to be utilised for isotopes further removed from the line of stability, are the subject of this study. Results are presented for the calculated distribution of compound nucleus states populated in 90Zr, via the 90Zr(p,t90Zr reaction, and are compared against measured data at an incident proton energy of 28.56 MeV.

  11. Postaurical injection is a systemic delivery supported by symmetric distribution of Gd-DOTA in both the ipsilateral and contralateral ears☆

    Institute of Scientific and Technical Information of China (English)

    Jing Zou

    2015-01-01

    Postaurical injection of therapeutics was recently applied in clinical practice to treat inner ear diseases based on supposed existence of a direct channel from the postaurical area to the inner ear. Doubting on the associated reports and aiming to provide evidence on the inner ear uptake mechanism, the present study tracked the dynamic distribution of gadolinium-tetra-azacyclo-dodecane-tetra-acetic acid (Gd-DOTA) in rat inner ears after postaurical injection using MRI. A targeted tympanic medial wall delivery was utilized as control. The results showed that, at the early time points after postaurical injection, Gd-DOTA distributed mainly in tissues surrounding the bulla, temporal bone and skull and neck space. In the inner ear, there was gradual uptake of Gd-DOTA on both the ipsilateral and contralateral sides with equal signal intensities. There was no sign of direct channel carrying the agent from the postaurical area to the inner ear. Targeted tympanic medial wall delivery induced significantly greater uptake of Gd-DOTA in the inner ear than did postaurical injection. At 30 min post-administration, targeted tympanic medial wall delivery yielded 4.6-folds higher signal intensity than did postaurical injection. The total dose of Gd-DOTA delivered by the targeted tympanic medial wall approach was only 0.1% of that delivered by postaurical injection. In conclusion, postaurical injection is a systemic administration, which is similar to hypodermic injection, rather than a focal delivery method. By contraries, targeted tympanic medial wall delivery induces fast and abundant uptake of Gd-DOTA in the ipsilateral inner ear without significant distribution in unwanted areas.

  12. Why choose Random Forest to predict rare species distribution with few samples in large undersampled areas? Three Asian crane species models provide supporting evidence.

    Science.gov (United States)

    Mi, Chunrong; Huettmann, Falk; Guo, Yumin; Han, Xuesong; Wen, Lijia

    2017-01-01

    Species distribution models (SDMs) have become an essential tool in ecology, biogeography, evolution and, more recently, in conservation biology. How to generalize species distributions in large undersampled areas, especially with few samples, is a fundamental issue of SDMs. In order to explore this issue, we used the best available presence records for the Hooded Crane (Grus monacha, n = 33), White-naped Crane (Grus vipio, n = 40), and Black-necked Crane (Grus nigricollis, n = 75) in China as three case studies, employing four powerful and commonly used machine learning algorithms to map the breeding distributions of the three species: TreeNet (Stochastic Gradient Boosting, Boosted Regression Tree Model), Random Forest, CART (Classification and Regression Tree) and Maxent (Maximum Entropy Models). In addition, we developed an ensemble forecast by averaging predicted probability of the above four models results. Commonly used model performance metrics (Area under ROC (AUC) and true skill statistic (TSS)) were employed to evaluate model accuracy. The latest satellite tracking data and compiled literature data were used as two independent testing datasets to confront model predictions. We found Random Forest demonstrated the best performance for the most assessment method, provided a better model fit to the testing data, and achieved better species range maps for each crane species in undersampled areas. Random Forest has been generally available for more than 20 years and has been known to perform extremely well in ecological predictions. However, while increasingly on the rise, its potential is still widely underused in conservation, (spatial) ecological applications and for inference. Our results show that it informs ecological and biogeographical theories as well as being suitable for conservation applications, specifically when the study area is undersampled. This method helps to save model-selection time and effort, and allows robust and rapid

  13. A study of a space communication system for the control and monitoring of the electric distribution system. Volume 2: Supporting data and analyses

    Science.gov (United States)

    Vaisnys, A.

    1980-01-01

    It is technically feasible to design a satellite communication system to serve the United States electric utility industry's needs relative to load management, real-time operations management, remote meter reading and to determine the costs of various elements of the system. The functions associated with distribution automation and control and communication system requirements are defined. Factors related to formulating viable communication concepts, the relationship of various design factors to utility operating practices, and the results of the cost analysis are discussed The system concept and several ways in which the concept could be integrated into the utility industry are described.

  14. Heat rate variability and dyssomnia and their correlations to neurological defects in cerebral infarction patients complicated by insomnia A concurrent non-randomized case-control study

    Institute of Scientific and Technical Information of China (English)

    Jianping Chu; Xueli Shen; Jun Fan; Changhai Chen; Shuyang Lin

    2008-01-01

    autonomic nerve analyzer (Weijin Science and Technology Co., Ltd., Taiwan). Each frequency spectrum parameter of heart rate variability was obtained, including very low frequency, low fre-quency, high frequency, total power, R-R interval, and its mean square. In addition, percentage of low fre-quency, high frequency, and ratio of low frequency to high frequency were calculated. For each heart rate frequency spectrum parameter, the difference between groups was analyzed. Moreover, correlations of each frequency spectrum parameter with insomnia and disease condition were analyzed. Data from each index, which were not normally distributed, were processed by logarithmic transformation. The t-test was used for the comparison of intergroup differences. Single-factor linear regression analysis and t-test were used for the analysis of factor-factor correlation and coefficient of correlation, respectively. MAIN OUTCOME MEASURES: ①Differences of scores in the National Institutes of Health Stroke Scale and Pittsburgh Sleep Quality Index between the simple cerebral infarction group and the cerebral in-farction complicated by insomnia group. ② Differences of heart rate variability parameters between the simple cerebral infarction group and the control group. ③ Correlation of heart rate variability parameters, the Pittsburgh Sleep Quality Index score, and the neurological impairment score.RESULTS: Sixty patients and thirty healthy controls were included in the final analysis. ① The scores of the Pittsburgh Sleep Quality Index and the neurological impairment were significantly higher in the cerebral infarction complicated by insomnia group compared to the simple cerebral infarction group (P < 0.05–0.01). ② R-R interval was significantly longer in the simple cerebral infarction group than in the control group, while R-R interval variance and high-frequency band were significantly lower in the simple cerebral infarc-tion group compared to the control group (P < 0.05). ③ For

  15. Automated cardiopulmonary resuscitation using a load-distributing band external cardiac support device for in-hospital cardiac arrest: a single centre experience of AutoPulse-CPR.

    Science.gov (United States)

    Spiro, J R; White, S; Quinn, N; Gubran, C J; Ludman, P F; Townend, J N; Doshi, S N

    2015-02-01

    Poor quality cardiopulmonary resuscitation (CPR) predicts adverse outcome. During invasive cardiac procedures automated-CPR (A-CPR) may help maintain effective resuscitation. The use of A-CPR following in-hospital cardiac arrest (IHCA) remains poorly described. Firstly, we aimed to assess the efficiency of healthcare staff using A-CPR in a cardiac arrest scenario at baseline, following re-training and over time (Scenario-based training). Secondly, we studied our clinical experience of A-CPR at our institution over a 2-year period, with particular emphasis on the details of invasive cardiac procedures performed, problems encountered, resuscitation rates and in-hospital outcome (AutoPulse-CPR Registry). Scenario-based training: Forty healthcare professionals were assessed. At baseline, time-to-position device was slow (mean 59 (±24) s (range 15-96s)), with the majority (57%) unable to mode-switch. Following re-training time-to-position reduced (28 (±9) s, pCPR Registry: 285 patients suffered IHCA, 25 received A-CPR. Survival to hospital discharge following conventional CPR was 28/260 (11%) and 7/25 (28%) following A-CPR. A-CPR supported invasive procedures in 9 patients, 2 of whom had A-CPR dependant circulation during transfer to the catheter lab. A-CPR may provide excellent haemodynamic support and facilitate simultaneous invasive cardiac procedures. A significant learning curve exists when integrating A-CPR into clinical practice. Further studies are required to better define the role and effectiveness of A-CPR following IHCA. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  16. Effect of cantilever length and alloy framework on the stress distribution in peri-implant area of cantilevered implant-supported fixed partial dentures

    Directory of Open Access Journals (Sweden)

    Valdey SUEDAM

    2016-04-01

    Full Text Available ABSTRACT Because many mechanical variables are present in the oral cavity, the proper load transfer between the prosthesis and the bone is important for treatment planning and for the longevity of the implant-supported fixed partial denture. Objectives To verify the stress generated on the peri-implant area of cantilevered implant-supported fixed partial dentures and the potential effects of such variable. Material and Methods A U-shaped polyurethane model simulating the mandibular bone containing two implants (Ø 3.75 mm was used. Six groups were formed according to the alloy’s framework (CoCr or PdAg and the point of load application (5 mm, 10 mm and 15 mm of cantilever arm. A 300 N load was applied in pre-determined reference points. The tension generated on the mesial, lingual, distal and buccal sides of the peri-implant regions was assessed using strain gauges. Results Two-way ANOVA and Tukey statistical tests were applied showing significant differences (p<0.05 between the groups. Pearson correlation test (p<0.05 was applied showing positive correlations between the increase of the cantilever arm and the deformation of the peri-implant area. Conclusions This report demonstrated the CoCr alloy shows larger compression values compared to the PdAg alloy for the same distances of cantilever. The point of load application influences the deformation on the peri-implant area, increasing in accordance with the increase of the lever arm.

  17. Calibration and parameterization of a semi-distributed hydrological model to support sub-daily ensemble flood forecasting; a watershed in southeast Brazil

    Science.gov (United States)

    de Almeida Bressiani, D.; Srinivasan, R.; Mendiondo, E. M.

    2013-12-01

    The use of distributed or semi-distributed models to represent the processes and dynamics of a watershed in the last few years has increased. These models are important tools to predict and forecast the hydrological responses of the watersheds, and they can subside disaster risk management and planning. However they usually have a lot of parameters, of which, due to the spatial and temporal variability of the processes, are not known, specially in developing countries; therefore a robust and sensible calibration is very important. This study conduced a sub-daily calibration and parameterization of the Soil & Water Assessment Tool (SWAT) for a 12,600 km2 watershed in southeast Brazil, and uses ensemble forecasts to evaluate if the model can be used as a tool for flood forecasting. The Piracicaba Watershed, in São Paulo State, is mainly rural, but has about 4 million of population in highly relevant urban areas, and three cities in the list of critical cities of the National Center for Natural Disasters Monitoring and Alerts. For calibration: the watershed was divided in areas with similar hydrological characteristics, for each of these areas one gauge station was chosen for calibration; this procedure was performed to evaluate the effectiveness of calibrating in fewer places, since areas with the same group of groundwater, soil, land use and slope characteristics should have similar parameters; making calibration a less time-consuming task. The sensibility analysis and calibration were performed on the software SWAT-CUP with the optimization algorithm: Sequential Uncertainly Fitting Version 2 (SUFI-2), which uses Latin hypercube sampling scheme in an iterative process. The performance of the models to evaluate the calibration and validation was done with: Nash-Sutcliffe efficiency coefficient (NSE), determination coefficient (r2), root mean square error (RMSE), and percent bias (PBIAS), with monthly average values of NSE around 0.70, r2 of 0.9, normalized RMSE of 0

  18. Fracture resistance and analysis of stress distribution of implant-supported single zirconium ceramic coping combination with abutments made of different materials.

    Science.gov (United States)

    Firidinoğlu, Kadir; Toksavul, Suna; Toman, Muhittin; Sarikanat, Mehmet; Nergiz, Ibrahim

    2012-08-01

    The purpose of this study was to compare the fracture resistance and fracture mode of single implant-zirconium coping combinations using zirconium and titanium abutments and to analyze the stress distribution pattern using three-dimensional finite elements analysis. Twenty implants with titanium and zirconium abutments were randomly divided into two groups (n = 10) and into resin blocks. Zirconium copings were cemented onto the abutments. The specimens were loaded with 135° angles to the long axis and the load values at the moment of failure were recorded using a universal test machine. Stress levels were calculated according to the maximum Von Mises criteria. The fracture resistances for titanium and zirconium abutment groups were 525.65 N and 514.05 N, respectively. No significant differences were observed between two groups regarding the fracture resistance levels. The maximum Von Mises equivalent stress concentrated on zirconium copings in both of the groups. Implant-abutment-ZrO2 coping combination has the potential to withstand physiological occlusal forces in the anterior region. Three-dimensional finite elements analysis results of the implant-abutment-ZrO2 coping combination is compatible with the results of fracture resistance.

  19. Could Insoles Offload Pressure? An Evaluation of the Effects of Arch-supported Functional Insoles on Plantar Pressure Distribution during Race Walking.

    Science.gov (United States)

    Song, Qipeng; Xu, Kaisheng; Yu, Bing; Zhang, Cui; Sun, Wei; Mao, Dewei

    2015-01-01

    This study investigated the effectiveness of functional insoles on plantar pressure distribution during race walking so as to reduce the high plantar pressure and force on race walkers, who tend to suffer from overuse injury. A total of 20 male race walkers aged 21.19 ± 3.66 years and with a mean height of 178.85 ± 14.07 cm were recruited as participants. Each participant completed a race walking with functional or normal insoles. Plantar pressure insoles were used to collect vertical plantar pressure data. A two-way analysis of variance with a mixed design was used to determine the difference between the two conditions. Results showed that the use of functional insoles reduces the peak pressure and the impulse in the metatarsophalangeal joints and heels and thus suggest that functional insoles reduce the overuse injury risks of these parts. The first ground reaction force peak also decreased. This result suggested that functional insoles reduce the risks of foot and leg injuries.

  20. Sandia`s network for SC `97: Supporting visualization, distributed cluster computing, and production data networking with a wide area high performance parallel asynchronous transfer mode (ATM) network

    Energy Technology Data Exchange (ETDEWEB)

    Pratt, T.J.; Martinez, L.G.; Vahle, M.O.; Archuleta, T.V.; Williams, V.K.

    1998-05-01

    The advanced networking department at Sandia National Laboratories has used the annual Supercomputing conference sponsored by the IEEE and ACM for the past several years as a forum to demonstrate and focus communication and networking developments. At SC `97, Sandia National Laboratories (SNL), Los Alamos National Laboratory (LANL), and Lawrence Livermore National Laboratory (LLNL) combined their SC `97 activities within a single research booth under the Advance Strategic Computing Initiative (ASCI) banner. For the second year in a row, Sandia provided the network design and coordinated the networking activities within the booth. At SC `97, Sandia elected to demonstrate the capability of the Computation Plant, the visualization of scientific data, scalable ATM encryption, and ATM video and telephony capabilities. At SC `97, LLNL demonstrated an application, called RIPTIDE, that also required significant networking resources. The RIPTIDE application had computational visualization and steering capabilities. This paper documents those accomplishments, discusses the details of their implementation, and describes how these demonstrations support Sandia`s overall strategies in ATM networking.

  1. Non-random patterns in viral diversity

    DEFF Research Database (Denmark)

    Anthony, Simon J.; Islam, Ariful; Johnson, Christine

    2015-01-01

    It is currently unclear whether changes in viral communities will ever be predictable. Here we investigate whether viral communities in wildlife are inherently structured (inferring predictability) by looking at whether communities are assembled through deterministic (often predictable) or stocha...

  2. 支持分布式能源建设美丽中国%Support distributed energy source to build beautiful China

    Institute of Scientific and Technical Information of China (English)

    韩晓平

    2013-01-01

      分布式能源和能源服务产业将把电力需求侧管理带入新的时代。介绍扁平化的互联网式能源系统及其对提升能源利用效率、提高能源的自保能力和能源安全的重要性,提出中国生态文明建设的关键是能源结构的调整和能源利用方式的根本转变,科学利用我国丰富的常规和非常规天然气资源,使我国能源利用转型到天然气和可再生能源为主的清洁能源的新时代。%DSM will be led into a new era by distributed ener⁃gy and energy service industry. Flattened Internet energy systems and the importance to enhance the energy efficiency, the energy self⁃protection and energy security is introduced. The article pro⁃posed the critical of ecological civilization construction is the ad⁃justment of energy structure and fundamental change of energy use. With our rich conventional and unconventional natural gas re⁃sources scientific, China will come into a new era with energy use transition to a natural gas and renewable energy⁃based clean energy.

  3. The pattern of complaints about Australian wind farms does not match the establishment and distribution of turbines: support for the psychogenic, 'communicated disease' hypothesis.

    Directory of Open Access Journals (Sweden)

    Simon Chapman

    Full Text Available BACKGROUND AND OBJECTIVES: With often florid allegations about health problems arising from wind turbine exposure now widespread, nocebo effects potentially confound any future investigation of turbine health impact. Historical audits of health complaints are therefore important. We test 4 hypotheses relevant to psychogenic explanations of the variable timing and distribution of health and noise complaints about wind farms in Australia. SETTING: All Australian wind farms (51 with 1634 turbines operating 1993-2012. METHODS: Records of complaints about noise or health from residents living near 51 Australian wind farms were obtained from all wind farm companies, and corroborated with complaints in submissions to 3 government public enquiries and news media records and court affidavits. These are expressed as proportions of estimated populations residing within 5 km of wind farms. RESULTS: There are large historical and geographical variations in wind farm complaints. 33/51 (64.7% of Australian wind farms including 18/34 (52.9% with turbine size >1 MW have never been subject to noise or health complaints. These 33 farms have an estimated 21,633 residents within 5 km and have operated complaint-free for a cumulative 267 years. Western Australia and Tasmania have seen no complaints. 129 individuals across Australia (1 in 254 residents appear to have ever complained, with 94 (73% being residents near 6 wind farms targeted by anti wind farm groups. The large majority 116/129(90% of complainants made their first complaint after 2009 when anti wind farm groups began to add health concerns to their wider opposition. In the preceding years, health or noise complaints were rare despite large and small-turbine wind farms having operated for many years. CONCLUSIONS: The reported historical and geographical variations in complaints are consistent with psychogenic hypotheses that expressed health problems are "communicated diseases" with nocebo effects likely

  4. Complex Systems Analysis of Cell Cycling Models in Carcinogenesis:II. Cell Genome and Interactome, Neoplastic Non-random Transformation Models in Topoi with Lukasiewicz-Logic and MV Algebras

    CERN Document Server

    Baianu, I C

    2004-01-01

    Quantitative Biology, abstract q-bio.OT/0406045 From: I.C. Baianu Dr. [view email] Date (v1): Thu, 24 Jun 2004 02:45:13 GMT (164kb) Date (revised v2): Fri, 2 Jul 2004 00:58:06 GMT (160kb) Complex Systems Analysis of Cell Cycling Models in Carcinogenesis: II. Authors: I.C. Baianu Comments: 23 pages, 1 Figure Report-no: CC04 Subj-class: Other Carcinogenesis is a complex process that involves dynamically inter-connected modular sub-networks that evolve under the influence of micro-environmentally induced perturbations, in non-random, pseudo-Markov chain processes. An appropriate n-stage model of carcinogenesis involves therefore n-valued Logic treatments of nonlinear dynamic transformations of complex functional genomes and cell interactomes. Lukasiewicz Algebraic Logic models of genetic networks and signaling pathways in cells are formulated in terms of nonlinear dynamic systems with n-state components that allow for the generalization of previous, Boolean or "fuzzy", logic models of genetic activities in vivo....

  5. The study protocol for a non-randomized controlled clinical trial using a genotype-guided strategy in a dataset of patients who undergone percutaneous coronary intervention with stent

    Directory of Open Access Journals (Sweden)

    Cristina Lucía Dávila-Fajardo

    2017-02-01

    Full Text Available This article contains data related to the research article entitled “Results of genotype–guided antiplatelet therapy in patients undergone percutaneous coronary intervention with stent” (J. Sánchez-Ramos, C.L. Dávila-Fajardo, P. Toledo Frías, X. Díaz Villamarín, L.J. Martínez-González, S. Martínez Huertas, F. Burillo Gómez, J. Caballero Borrego, A. Bautista Pavés, M.C. Marín Guzmán, J.A. Ramirez Hernández, C. Correa Vilches, J. Cabeza Barrera, 2016 (1. This data article reports, for the first time, about the non-randomized clinical trial protocol that check if CYP2C19/ABCB1 genotype–guided strategy in which the choice of antiplatelet therapy is based on the genetic test, reduces the rates of cardiovascular events and bleeding compared to a non-tailored strategy in patients undergone percutaneous coronary intervention (PCI with stent. The data included in this article are: design and setting of the study, study population, inclusion and exclusion criteria, definition of the intervention, objectives, variables (baseline characteristics and during the follow-up, study procedures, collection and treatment of the biological sample, genotyping, withdrawal criteria, sample size, statistic analysis, ethical aspects, information sheet and consent form. The authors confirm that this study has been registered in Eudra CT (Eudra CT: 2016-001294-33.

  6. A non-randomized confirmatory trial of segmentectomy for clinical T1N0 lung cancer with dominant ground glass opacity based on thin-section computed tomography (JCOG1211).

    Science.gov (United States)

    Aokage, Keiju; Saji, Hisashi; Suzuki, Kenji; Mizutani, Tomonori; Katayama, Hiroshi; Shibata, Taro; Watanabe, Syunichi; Asamura, Hisao

    2017-05-01

    Lobectomy has been the standard surgery for even stage I lung cancer since the validity of limited resection for stage I lung cancer was denied by the randomized study reported in 1995. The aim of this non-randomized confirmatory going on since September 2013 is to confirm the efficacy of a segmentectomy for clinical T1N0 lung cancer with dominant ground glass opacity based on thin-slice computed tomography. A total of 390 patients from 42 Japanese institutions are recruited within 4 years. The primary endpoint of this study is a 5-year relapse-free survival in all of the patients who undergo a segmentectomy for a lung nodule. The secondary endpoints are overall survival, annual relapse-free survival, disease-free survival, proportion of local relapse, postoperative pulmonary function, proportion of segmentectomy completion, proportion of R0 resection completion by segmentectomy, adverse events, and serious adverse events. This trial has been registered at the UMIN Clinical Trials Registry as UMIN000011819 ( http://www.umin.ac.jp/ctr/ ). Patient's accrual has been already finished in November, 2015 and the primary analysis will be performed in 2021. This study is one of the pivotal trial of lung segmentectomy for early lung cancer. The result will provide a clear evidence for our daily clinics and will be possible contribution to preserving pulmonary function for lung cancer patients.

  7. A machine learning methodology for the selection and classification of spontaneous spinal cord dorsum potentials allows disclosure of structured (non-random changes in neuronal connectivity induced by nociceptive stimulation

    Directory of Open Access Journals (Sweden)

    Mario eMartin

    2015-08-01

    Full Text Available Fractal analysis of spontaneous cord dorsum potentials (CDPs generated in the lumbosacral spinal segments has revealed that these potentials are generated by ongoing structured (non-random neuronal activity. Studies aimed to disclose the changes produced by nociceptive stimulation on the functional organization of the neuronal networks generating these potentials used predetermined templates to select specific classes of spontaneous CDPs. Since this procedure was time consuming and required continuous supervision, it was limited to the analysis of two types of CDPs (negative CDPs and negative positive CDPs, thus excluding potentials that may reflect activation of other neuronal networks of presumed functional relevance. We now present a novel procedure based in machine learning that allows the efficient and unbiased selection of a variety of spontaneous CDPs with different shapes and amplitudes. The reliability and performance of the method is evaluated by analyzing the effects on the probabilities of generation of different types of spontaneous CDPs induced by the intradermic injection of small amounts of capsaicin in the anesthetized cat.The results obtained with the selection method presently described allowed detection of spontaneous CDPs with specific shapes and amplitudes that are assumed to represent the activation of functionally coupled sets of dorsal horn neurones that acquire different, structured configurations in response to nociceptive stimuli.

  8. Adalimumab specifically induces CD3+ CD4+ CD25high Foxp3+ CD127− T-regulatory cells and decreases vascular endothelial growth factor plasma levels in refractory immuno-mediated uveitis: a non-randomized pilot intervention study

    Science.gov (United States)

    Calleja, S; Cordero-Coma, M; Rodriguez, E; Llorente, M; Franco, M; Ruiz de Morales, J G

    2012-01-01

    Aim To explore immunoregulatory and anti-inflammatory pathways specifically targeted by a subcutaneous anti-TNFαdrug—adalimumab—which might be relevant for controlling refractory uveitis. Design Non-randomized pilot intervention study on the effects of adalimumab on Treg populations and plasma VEGF levels in refractory uveitis patients. Inflammatory and immunological parameters were measured in 12 patients before therapy, and 1 and 6 months after therapy, and analyzed in the context of ophthalmological outcomes. The results were compared with those obtained in 10 systemic prednisone-treated uveitis patients. Results After 1 month of treatment, all patients responded, with 67% of adalimumab group and 80% of the corticosteroid group achieving inactivity (P=0.5). Unlike steroid-treated patients, a significant increase in T-regulatory CD4+ CD25high Foxp3+ CD127− cells was observed in adalimumab patients after 1 month of treatment, and maintained after 6 months (P=0.003). A significant adalimumab-specific drop in plasma VEGF was observed after 1 and 6 months of treatment (P=0.019). In every single patient, Tregs but not VEGF correlated with disease activity. Conclusions In refractory uveitis patients treated with adalimumab, clinical efficacy may be mediated through upregulation of Tregs in addition to modulation of VEGF-mediated inflammatory pathways. These biological properties, which were not observed in patients treated with corticosteroids, may reflect the specificity of TNF-αtargeting. PMID:22222264

  9. The Relationship between Participation in Decision Making, and Supervisor\\\\\\'s Perceived Support with Organizational Citizenship Behaviors among Employees, with Emphasis on the Mediating Role of Procedural and Perceived Distributive Justices

    Directory of Open Access Journals (Sweden)

    2015-06-01

    Full Text Available Introduction   Among different organizational variables, social exchange theory has had an effective role in explaining and perceiving organizational citizenship behavior (OCB and organizational justice. Exchange of justice is an important aspect of social exchange theory. A number of studies have investigated the relationship between perceived organizational justice and employees' attitudes. However, the issue that is examined in organizational justice and OCB is how employees should be treated such that they perceive the existence of justice in the organization. This study aimed at examining a proposed model based on the mediating role of procedural and perceived distributive justices in the relationship between supervisor's perceived support and participation in decision making with organizational citizenship behavior       Materials & Methods   The present study is of relational type. The population of the study include all employees of Agricultural Society of Kohgiluyeh and Boyer Ahmad in Iran in 2011. From 490 employees, 120 were selected based on simple random sampling method. The questionnaires in this study include (1 Participation in decision-making inventory that was invented by Parnel and Bell (2001, (2 Supervisor's support inventory that was made by Eisenberger et al. (1986, (3 Organizational citizenship behavior questionnaire which was invented by Smith et al. (1983, (4 Distributive Justice Inventory as was made by Colquitt (2001, and (5 Procedural Justice Inventory as was made by Niehoff and Moorman (1993. Also, the analysis of the data started with preliminary analysis (zero-order Pearson correlations to gain a basic insight of data. Then, more sophisticated analyzes were performed to assess the fitness of the proposed model, all of which were performed by Structural equation modeling (SEM using maximum likelihood estimation of AMOS software, 16th version (Arbuckle, 1997. In order to determine that whether the proposed

  10. A non-randomized clinical control trial of Harrison mirror image methods for correcting trunk list (lateral translations of the thoracic cage) in patients with chronic low back pain.

    Science.gov (United States)

    Harrison, Deed E; Cailliet, Rene; Betz, Joseph W; Harrison, Donald D; Colloca, Christopher J; Haas, Jason W; Janik, Tadeusz J; Holland, Burt

    2005-03-01

    Spinal trunk list is a common occurrence in clinical practice, but few conservative methods of spinal rehabilitation have been reported. This study is a non-randomized clinical control trial of 63 consecutive retrospective subjects undergoing spinal rehabilitation and 23 prospective volunteer controls. All subjects presented with lateral thoracic-cage-translation posture (trunk list) and chronic low back pain. Initial and follow-up numerical pain rating scales (NRS) and AP lumbar radiographs were obtained after a mean of 11.5 weeks of care (average of 36 visits) for the treatment group and after a mean of 37.5 weeks for the control group. The radiographs were digitized and analyzed for a horizontal displacement of T12 from the second sacral tubercle, verticality of the lumbar spine at the sacral base, and any dextro/levo angle at mid-lumbar spine. Treatment subjects received the Harrison mirror image postural correction methods, which included an opposite trunk-list exercise and a new method of opposite trunk-list traction. Control subjects did not receive spinal rehabilitation therapy, but rather self-managed their back pain. For the treatment group, there were statistically significant improvements (approximately 50%) in all radiographic measurements and a decrease in pain intensity (NRS: 3.0 to 0.8). For the control group, no significant radiographic and NRS differences were found, except in trunk-list displacement of T12 to S1, worsened by 2.4 mm. Mirror image (opposite posture) postural corrective exercises and a new method of trunk-list traction resulted in 50% reduction in trunk list and were associated with nearly resolved pain intensity in this patient population. The findings warrant further study in the conservative treatment of chronic low back pain and spinal disorders.

  11. Mindfulness Training for Health Profession Students-The Effect of Mindfulness Training on Psychological Well-Being, Learning and Clinical Performance of Health Professional Students: A Systematic Review of Randomized and Non-randomized Controlled Trials.

    Science.gov (United States)

    McConville, Janet; McAleer, Rachael; Hahne, Andrew

    High levels of stress have been identified in medical students and increasingly in other health profession student population groups. As stress can affect psychological well-being and interfere with learning and clinical performance, there is a clear argument for universities to include health professional student well-being as an outcome in core curriculum. Mindfulness training is a potential construct to manage stress and enhance academic success. The aims of this systematic review were to assess the effectiveness of mindfulness training in medical and other health professional student population groups and to compare the effectiveness of the different mindfulness-based programs. A literature search was completed using The Cochrane library, Medline, Cinahl, Embase, Psychinfo, and ERIC (proquest) electronic databases from inception to June 2016. Randomized and non-randomized controlled trials were included. Of the potential 5355 articles, 19 met the inclusion criteria. Studies focused on medical (n = 10), nursing (n = 4), social work (n = 1), psychology (n = 1), and medical plus other health (n = 3) students. Interventions were based on mindfulness. The 19 studies included 1815 participants. Meta-analysis was performed evaluating the effect of mindfulness training on mindfulness, anxiety, depression, stress, mood, self-efficacy, and empathy. The effect of mindfulness on academic performance was discussed. Mindfulness-based interventions decrease stress, anxiety, and depression and improve mindfulness, mood, self-efficacy, and empathy in health profession students. Due to the range of presentation options, mindfulness training can be relatively easily adapted and integrated into health professional training programs. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Impact of a Multifaceted and Clinically Integrated Training Program in Evidence-Based Practice on Knowledge, Skills, Beliefs and Behaviour among Clinical Instructors in Physiotherapy: A Non-Randomized Controlled Study.

    Directory of Open Access Journals (Sweden)

    Nina Rydland Olsen

    Full Text Available Physiotherapists practicing at clinical placement sites assigned the role as clinical instructors (CIs, are responsible for supervising physiotherapy students. For CIs to role model evidence-based practice (EBP they need EBP competence. The aim of this study was to assess the short and long term impact of a six-month multifaceted and clinically integrated training program in EBP on the knowledge, skills, beliefs and behaviour of CIs supervising physiotherapy students.We invited 37 CIs to participate in this non-randomized controlled study. Three self-administered questionnaires were used pre- and post-intervention, and at six-month follow-up: 1 The Adapted Fresno test (AFT, 2 the EBP Belief Scale and 3 the EBP Implementation Scale. The analysis approach was linear regression modeling using Generalized Estimating Equations.In total, 29 CIs agreed to participate in the study: 14 were invited to participate in the intervention group and 15 were invited to participate in the control group. One in the intervention group and five in the control group were lost to follow-up. At follow-up, the group difference was statistically significant for the AFT (mean difference = 37, 95% CI (15.9 -58.1, p < 0.001 and the EBP Beliefs scale (mean difference = 8.1, 95% CI (3.1 -13.2, p = 0.002, but not for the EBP Implementation scale (mean difference = 1.8. 95% CI (-4.5-8.1, p = 0.574. Comparing measurements over time, we found a statistically significant increase in mean scores related to all outcome measures for the intervention group only.A multifaceted and clinically integrated training program in EBP was successful in improving EBP knowledge, skills and beliefs among CIs. Future studies need to ensure long-term EBP behaviour change, in addition to assessing CIs' abilities to apply EBP knowledge and skills when supervising students.

  13. Impact of a Multifaceted and Clinically Integrated Training Program in Evidence-Based Practice on Knowledge, Skills, Beliefs and Behaviour among Clinical Instructors in Physiotherapy: A Non-Randomized Controlled Study

    Science.gov (United States)

    Olsen, Nina Rydland; Bradley, Peter; Espehaug, Birgitte; Nortvedt, Monica Wammen; Lygren, Hildegunn; Frisk, Bente; Bjordal, Jan Magnus

    2015-01-01

    Background and Purpose Physiotherapists practicing at clinical placement sites assigned the role as clinical instructors (CIs), are responsible for supervising physiotherapy students. For CIs to role model evidence-based practice (EBP) they need EBP competence. The aim of this study was to assess the short and long term impact of a six-month multifaceted and clinically integrated training program in EBP on the knowledge, skills, beliefs and behaviour of CIs supervising physiotherapy students. Methods We invited 37 CIs to participate in this non-randomized controlled study. Three self-administered questionnaires were used pre- and post-intervention, and at six-month follow-up: 1) The Adapted Fresno test (AFT), 2) the EBP Belief Scale and 3) the EBP Implementation Scale. The analysis approach was linear regression modeling using Generalized Estimating Equations. Results In total, 29 CIs agreed to participate in the study: 14 were invited to participate in the intervention group and 15 were invited to participate in the control group. One in the intervention group and five in the control group were lost to follow-up. At follow-up, the group difference was statistically significant for the AFT (mean difference = 37, 95% CI (15.9 -58.1), p<0.001) and the EBP Beliefs scale (mean difference = 8.1, 95% CI (3.1 -13.2), p = 0.002), but not for the EBP Implementation scale (mean difference = 1.8. 95% CI (-4.5-8.1), p = 0.574). Comparing measurements over time, we found a statistically significant increase in mean scores related to all outcome measures for the intervention group only. Conclusions A multifaceted and clinically integrated training program in EBP was successful in improving EBP knowledge, skills and beliefs among CIs. Future studies need to ensure long-term EBP behaviour change, in addition to assessing CIs’ abilities to apply EBP knowledge and skills when supervising students. PMID:25894559

  14. Software for the decision making support on the design of natural gas distribution networks; Software de apoio a decisao para o projeto de rede urbanas de distribuicao de gas natural

    Energy Technology Data Exchange (ETDEWEB)

    Goldbarg, Marco C.; Goldbarg, Elizabeth F.G. [Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN (Brazil); Campos, Michel F. [PETROBRAS, Rio de Janeiro, RJ (Brazil)

    2004-07-01

    This work presents a computational system to aid the decision making process of installing new networks to distribute natural gas in an urban area. The system is called POM-DIGAS. The purpose of the software is to optimize the design of natural gas distribution networks. The general optimization problem comprises two combinatorial problems. The first one refers to the definition of the network layout. In this problem the objective is to minimize the total length of the network. The second combinatorial problem considers the pipe size optimization in which one must choose the diameters of the pipes regarding the demand requirements. POM-DIGAS is a composite of models and algorithms developed to tackle the two combinatorial problems. Furthermore, the software has a geographic information mode, a tool to automatically acquire several types of data concerning the project and a mode with distinct flow equations in order to allow the utilization of different methodologies for computing the network flows. The system was applied to a case study developed for the city of Natal, Rio Grande do Norte. This work was supported by RedeGasEnergia, FINEP and PETROBRAS. (author)

  15. Software Supports Distributed Operations via the Internet

    Science.gov (United States)

    Norris, Jeffrey; Backers, Paul; Steinke, Robert

    2003-01-01

    Multi-mission Encrypted Communication System (MECS) is a computer program that enables authorized, geographically dispersed users to gain secure access to a common set of data files via the Internet. MECS is compatible with legacy application programs and a variety of operating systems. The MECS architecture is centered around maintaining consistent replicas of data files cached on remote computers. MECS monitors these files and, whenever one is changed, the changed file is committed to a master database as soon as network connectivity makes it possible to do so. MECS provides subscriptions for remote users to automatically receive new data as they are generated. Remote users can be producers as well as consumers of data. Whereas a prior program that provides some of the same services treats disconnection of a user from the network of users as an error from which recovery must be effected, MECS treats disconnection as a nominal state of the network: This leads to a different design that is more efficient for serving many users, each of whom typically connects and disconnects frequently and wants only a small fraction of the data at any given time.

  16. Distributed Emulation in Support of Large Networks

    Science.gov (United States)

    2016-06-01

    models. Multiple layers of the network stack such as: environmental characteristics, mobility pat - terns, traffic patterns, or routing protocols can be...www.gurobi.com/index. Access May. 29, 2016. [41] G. Brown and R. Dell, “Formulating linear and integer linear programs: A rouges’ gallery,” INFORMS

  17. The distribution of Elongation Factor-1 Alpha (EF-1alpha), Elongation Factor-Like (EFL), and a non-canonical genetic code in the ulvophyceae: discrete genetic characters support a consistent phylogenetic framework.

    Science.gov (United States)

    Gile, Gillian H; Novis, Philip M; Cragg, David S; Zuccarello, Giuseppe C; Keeling, Patrick J

    2009-01-01

    The systematics of the green algal class Ulvophyceae have been difficult to resolve with ultrastructural and molecular phylogenetic analyses. Therefore, we investigated relationships among ulvophycean orders by determining the distribution of two discrete genetic characters previously identified only in the order Dasycladales. First, Acetabularia acetabulum uses the core translation GTPase Elongation Factor 1alpha (EF-1alpha) while most Chlorophyta instead possess the related GTPase Elongation Factor-Like (EFL). Second, the nuclear genomes of dasycladaleans A. acetabulum and Batophora oerstedii use a rare non-canonical genetic code in which the canonical termination codons TAA and TAG instead encode glutamine. Representatives of Ulvales and Ulotrichales were found to encode EFL, while Caulerpales, Dasycladales, Siphonocladales, and Ignatius tetrasporus were found to encode EF-1alpha, in congruence with the two major lineages previously proposed for the Ulvophyceae. The EF-1alpha of I. tetrasporus supports its relationship with Caulerpales/Dasycladales/Siphonocladales, in agreement with ultrastructural evidence, but contrary to certain small subunit rRNA analyses that place it with Ulvales/Ulotrichales. The same non-canonical genetic code previously described in A. acetabulum was observed in EF-1alpha sequences from Parvocaulis pusillus (Dasycladales), Chaetomorpha coliformis, and Cladophora cf. crinalis (Siphonocladales), whereas Caulerpales use the universal code. This supports a sister relationship between Siphonocladales and Dasycladales and further refines our understanding of ulvophycean phylogeny.

  18. Bilateral matrix-exponential distributions

    DEFF Research Database (Denmark)

    Bladt, Mogens; Esparza, Luz Judith R; Nielsen, Bo Friis

    2012-01-01

    In this article we define the classes of bilateral and multivariate bilateral matrix-exponential distributions. These distributions have support on the entire real space and have rational moment-generating functions. These distributions extend the class of bilateral phasetype distributions of [1]...

  19. Does school-based physical activity decrease overweight and obesity in children aged 6-9 years? A two-year non-randomized longitudinal intervention study in the Czech Republic.

    Science.gov (United States)

    Sigmund, Erik; El Ansari, Walid; Sigmundová, Dagmar

    2012-07-29

    Globally, efforts aimed at the prevention of childhood obesity have led to the implementation of a range of school-based interventions. This study assessed whether augmenting physical activity (PA) within the school setting resulted in increased daily PA and decreased overweight/obesity levels in 6-9-year-old children. Across the first to third primary school years, PA of 84 girls and 92 boys was objectively monitored five times (each for seven successive days) using Yamax pedometer (step counts) and Caltrac accelerometer (activity energy expenditure AEE - kcal/kg per day). Four schools were selected to participate in the research (2 intervention, 2 controls), comprising intervention (43 girls, 45 boys) and control children (41 girls, 47 boys). The study was non-randomized and the intervention schools were selected on the basis of existing PA-conducive environment. Analyses of variance (ANOVA) for repeated measures examined the PA programme and gender effects on the step counts and AEE. Logistic regression (Enter method) determined the obesity and overweight occurrence prospect over the course of implementation of the PA intervention. There was a significant increase of school-based PA during schooldays in intervention children (from ≈ 1718 to ≈ 3247 steps per day; and from 2.1 to ≈ 3.6 Kcal/Kg per day) in comparison with the control children. Increased school-based PA of intervention children during schooldays contributed to them achieving >10,500 steps and >10.5 Kcal/Kg per school day across the 2 years of the study, and resulted in a stop of the decline in PA levels that is known to be associated with the increasing age of children. Increased school-based PA had also positive impact on leisure time PA of schooldays and on PA at weekends of intervention children. One year after the start of the PA intervention, the odds of being overweight or obese in the intervention children was almost three times lower than that of control children (p

  20. Responses of serum inflammatory factor high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-alpha in elderly males with cerebral infarction Non-randomized concurrent control

    Institute of Scientific and Technical Information of China (English)

    Guiping Jiao; Xinjie Tan; Zhiliu Yuan; Chunling Li; Jing Wang; Wen Mo

    2008-01-01

    BACKGROUND: Cerebral infarction is poorly treated due to neuronal necrosis and secondary pathophysiological changes; for example, free radical production and inflammatory reactions.OBJECTIVE: To detect the levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor nccrosis factor-α (TNF-α) in elderly males with cerebral infarction.DESIGN: Non-randomized current control study.SETTING: Cadre Medical Department, Guizhou Provincial People's Hospital.PARTICIPANTS: Forty elderly males (65-89 years old) with cerebral infarction were selected from Cadre Medical Department, Guizhou Provincial People's Hospital from February 2004 to December 2006. All patients met the diagnostic criteria of cerebral infarction modified at the 4th National Cerebrovascular Disease Academic Meeting, and were diagnosed on the basis of CT or MRI tests. Furthermore, 35 elderly male inpatients (65-87 years old) without cerebral infarction were selected as the control group. Included subjects provided confirmed consent and did not have heart disease, diabetes mellitus, lipid disorder, acute trauma, infection, rheumatism, or other inflammatory diseases. The study was approved by the local ethics committee. There were no significant differences in age, blood pressure, and lipid levels between the cerebral infarction group and the control group (P>0.05), and this suggested that the baseline data of both groups were comparable.METHODS: Fasting venous blood was drawn from cerebral infarction patients 24 hours after cerebral infarction attack and from control subjects 24 hours after hospitalization. A latex-enhanced immunoturbidimetric assay and an enzyme-linked immunosorbent assay were used to detect the levels of hs-CRP, IL-6, and TNF-α in the serum.MAIN OUTCOME MEASURES: The levels of hs-CRP, IL-6, and TNF-α in the serum in both groups.RESULTS: Forty cerebral infarction patients and thirty-five control subjects were included in the final analysis without any loss

  1. Estudos dos padrões de não aleatoriedade dos gráficos de controle de Shewhart: um enfoque probabilístico Studies on non-random patterns in Shewhart control charts

    Directory of Open Access Journals (Sweden)

    Quintiliano Siqueira Schroden Nomelini

    2009-09-01

    Full Text Available Além de investimento em novas tecnologias e modernização do parque industrial, a competitividade dos produtos brasileiros está ligada ao aumento de produtividade. O Controle Estatístico de Processo (CEP, junto com os gráficos de controle, inseriu-se neste contexto no que diz respeito ao controle das características significativas do produto e do processo, em tempo real, garantindo níveis de qualidade, a um custo exigido pelo mercado. Um procedimento importante é a interpretação dos gráficos de controle. Um estudo foi feito para ilustrar e discutir padrões de não aleatoriedade, que auxiliam na interpretação de tais gráficos. Alguns padrões de não aleatoriedade foram ilustrados e, por meio de cálculo de probabilidade, mostrou-se quais deles rejeitaram a hipótese de controle estatístico, a um nível de significância pré-especificado. Concluiu-se que os padrões mencionados na literatura não eram tão informativos. No que diz respeito ao nível de significância, observou-se então que em alguns padrões a um certo nível de significância retornaram resultados diferentes dos mencionados na literatura.In the last two decades, the Brazilian consuming market was modified by the insertion of products of better quality and minor cost. Statistical Process Control (SPC and control charts look after significant characteristics products and processes, in real time, guaranteeing quality levels, in a cost demanded by the market. In that context, an important procedure is the interpretation of the control charts; this is made through non-random patters. A study was made illustrating and arguing such standards. Standards had been illustrated and one revealed which of them, rejected the nullity hypothesis, under a determined significance. One concluded that the standards mentioned in literature are not so informative and can be improved.

  2. Effectiveness of the “What’s Up!” Intervention to Reduce Stigma and Psychometric Properties of the Youth Program Questionnaire (YPQ: Results from a Cluster Non-randomized Controlled Trial Conducted in Catalan High Schools

    Directory of Open Access Journals (Sweden)

    Laura Andrés-Rodríguez

    2017-09-01

    Full Text Available Mental disorders are highly prevalent in the general population, and people who experience them are frequently stigmatized. Stigma has a very negative impact on social, academic/professional, and personal life. Considering the high rates of mental disorders among children and adolescents (13.4% and how critical this age is in the formation of nuclear beliefs, many campaigns to combat stigma have been developed in the last decade, with mixed results. The OBERTAMENT initiative has produced various anti-stigma campaigns in Catalonia (Spain. In the present study, the main objective was to report on the effectiveness of the OBERTAMENT “What’s up!” intervention, a curricular intervention including education and social contact conducted by the teachers in the classroom with teenagers aged between 14 and 18. Prior to this, we examined the psychometric properties of the Youth Program Questionnaire (YPQ, our main outcome measure, in terms of dimensionality, reliability, and validity. A cluster non-randomized controlled trial was conducted to assess this intervention, which was tested in nine high schools situated in the Barcelona region. A convenience sample of 261 students formed the intervention group and 132 the control group (52% women, mean age = 14, SD = 0.47. The assignment to study conditions was conducted by Departament d’Ensenyament (Department of Education, Generalitat de Catalunya (Catalan Government. Participants were evaluated at baseline, post-intervention, and 9-month follow-up. The main outcome measure of this study was the YPQ. The Reported and Intended Behavior Scale (RIBS was used as secondary outcome measure. The statistical analysis indicated that the YPQ possesses a two-factor structure (stereotypical attitudes and intended behavior and sound psychometric properties. The multilevel mixed-effects models revealed statistically significant interactions for both study measures and post hoc intragroup analyses revealed a

  3. Nutritional Support

    Science.gov (United States)

    Nutritional support is therapy for people who cannot get enough nourishment by eating or drinking. You may ... absorb nutrients through your digestive system You receive nutritional support through a needle or catheter placed in ...

  4. DOLIB: Distributed Object Library

    Energy Technology Data Exchange (ETDEWEB)

    D`Azevedo, E.F.; Romine, C.H.

    1994-10-01

    This report describes the use and implementation of DOLIB (Distributed Object Library), a library of routines that emulates global or virtual shared memory on Intel multiprocessor systems. Access to a distributed global array is through explicit calls to gather and scatter. Advantages of using DOLIB include: dynamic allocation and freeing of huge (gigabyte) distributed arrays, both C and FORTRAN callable interfaces, and the ability to mix shared-memory and message-passing programming models for ease of use and optimal performance. DOLIB is independent of language and compiler extensions and requires no special operating system support. DOLIB also supports automatic caching of read-only data for high performance. The virtual shared memory support provided in DOLIB is well suited for implementing Lagrangian particle tracking techniques. We have also used DOLIB to create DONIO (Distributed Object Network I/O Library), which obtains over a 10-fold improvement in disk I/O performance on the Intel Paragon.

  5. The stress distribution on the supporting tissue of the maxillary complete denture with different compensate curve%不同补偿曲线的上颌全口义齿下支持组织的应力分布

    Institute of Scientific and Technical Information of China (English)

    安晓飞; 白乐康; 牛光良

    2012-01-01

    Objective: To study the stress distribution on the supporting tissue of the maxillary complete denture with different compensate curve. Methods: The 3D FEM was used to study the stress distribution on the supporting tissue of the maxillary complete denture with different compensate curve. Results: Loading on anterior teeth, the stress concentration was obvious in the labial frenum notch zone of edentulous ridge in the fourth model. Under unilateral posterior teeth loading conditions, the stress of the third model was highest in the area of anterior palatum. Under bilateral posterior teeth loading conditions, the stress of labia frenum notch zone, incisive papilla zone, middle palatum and posterior teeth crest were highest in the third model. Loading on all the teeth, the stress was highest in the labial frenum notch zone in the fourth model. Conclusion: Under occlusal force, the stress of the supporting tissue of the maxillary complete denture with normal compensate curve was lower than that of the complete denture with abnormal compensate curve. Therefore, to protect the health of alveolar bone, it is necessary tocorrect the abnormal compensate curve of the mandible teeth before the fabrication of a maxillary denture.%目的:研究补偿曲线对上颌全口义齿基托下支持组织应力分布的影响,为预防上颌骨组织吸收提供理论依据.方法:用三维有限元应力分析法研究不同补偿曲线时上颌全口义齿基托下支持组织应力及其分布状况.结果:前牙加载时,Ⅳ号模型唇系带切迹区压应力最大;单侧后牙加载时,Ⅲ号模型腭顶区压应力最大;双侧后牙加载时,Ⅲ号模型唇系带切迹、切牙乳突、腭顶、后牙嵴顶区压应力最大;全牙列加载时,Ⅳ号模型唇系带切迹区压应力最大.结论:在(牙合)力作用下,正常补偿曲线深度较异常补偿曲线深度的全口义齿模型,义齿基托下骨组织压应力值较小.义齿修复前应对下颌天然牙进行

  6. Evaluating the Effectiveness of an Antimicrobial Stewardship Program on Reducing the Incidence Rate of Healthcare-Associated Clostridium difficile Infection: A Non-Randomized, Stepped Wedge, Single-Site, Observational Study.

    Directory of Open Access Journals (Sweden)

    Giulio DiDiodato

    Full Text Available The incidence rate of healthcare-associated Clostridium difficile infection (HA-CDI is estimated at 1 in 100 patients. Antibiotic exposure is the most consistently reported risk factor for HA-CDI. Strategies to reduce the risk of HA-CDI have focused on reducing antibiotic utilization. Prospective audit and feedback is a commonly used antimicrobial stewardship intervention (ASi. The impact of this ASi on risk of HA-CDI is equivocal. This study examines the effectiveness of a prospective audit and feedback ASi on reducing the risk of HA-CDI.Single-site, 339 bed community-hospital in Barrie, Ontario, Canada. Primary outcome is HA-CDI incidence rate. Daily prospective and audit ASi is the exposure variable. ASi implemented across 6 wards in a non-randomized, stepped wedge design. Criteria for ASi; any intravenous antibiotic use for ≥ 48 hrs, any oral fluoroquinolone or oral second generation cephalosporin use for ≥ 48 hrs, or any antimicrobial use for ≥ 5 days. HA-CDI cases and model covariates were aggregated by ward, year and month starting September 2008 and ending February 2016. Multi-level mixed effect negative binomial regression analysis was used to model the primary outcome, with intercept and slope coefficients for ward-level random effects estimated. Other covariates tested for inclusion in the final model were derived from previously published risk factors. Deviance residuals were used to assess the model's goodness-of-fit.The dataset included 486 observation periods, of which 350 were control periods and 136 were intervention periods. After accounting for all other model covariates, the estimated overall ASi incidence rate ratio (IRR was 0.48 (95% 0.30, 0.79. The ASi effect was independent of antimicrobial utilization. The ASi did not seem to reduce the risk of Clostridium difficile infection on the surgery wards (IRR 0.87, 95% CI 0.45, 1.69 compared to the medicine wards (IRR 0.42, 95% CI 0.28, 0.63. The ward-level burden of

  7. Managing Distributed Software Projects

    DEFF Research Database (Denmark)

    Persson, John Stouby

    Increasingly, software projects are becoming geographically distributed, with limited face-toface interaction between participants. These projects face particular challenges that need careful managerial attention. This PhD study reports on how we can understand and support the management of distr......Increasingly, software projects are becoming geographically distributed, with limited face-toface interaction between participants. These projects face particular challenges that need careful managerial attention. This PhD study reports on how we can understand and support the management...... of distributed software projects, based on a literature study and a case study. The main emphasis of the literature study was on how to support the management of distributed software projects, but also contributed to an understanding of these projects. The main emphasis of the case study was on how to understand...... the management of distributed software projects, but also contributed to supporting the management of these projects. The literature study integrates what we know about risks and risk-resolution techniques, into a framework for managing risks in distributed contexts. This framework was developed iteratively...

  8. Distributed Computing Model and Supporting Technologies for the Dynamic Allocation of Internet Resources%Internet资源动态分配的分布计算模型及其系统支撑技术

    Institute of Scientific and Technical Information of China (English)

    彭宇行; 吴吉庆; 沈锐

    2011-01-01

    Internet computing becomes more and more popular, such as peer-to-peer, grid and cloud computing. Resource allocation problem is a key problem of all kinds of Internet applications. However, the dynamics of Internet resources makes the resource allocation problem one of the challenging issues on the Internet. Aiming at the issue, this paper presents a computational model of the dynamic Internet resource allocation and some related distributed algorithms. Firstly, the dynamics of the Internet resources is analyzed and the result shows which characteristics are invariable in resource allocation process. Secondly, based on the invariable characteristics during the resource allocation process, an organization model of distributed resources, a computational model of allocating resources and the APIs for use of Internet resources are presented. Thirdly, some distributed resource allocation algorithms on system level, such as publishing resources and requesting resources, are presented to support the models. In addition, the definition of good serving peer and the good serving peer selection algorithm are given. Finally, based on the models, two Internet applications are tested. The experiment results show that the models and the algorithms are effective and that the good serving peer selection algorithm can decrease the ratio of the rejected request drastically.%Internet资源的动态性使得资源分配问题已成为阻碍Internet资源获得充分利用的一大难题.为方便用户进行Internet应用开发,提出了一个资源动态分配的分布计算模型以及相关的分布处理算法.首先,通过分析Internet资源的动态性,分别从资源申请者和资源提供者的角度给出了资源分配过程中哪些特性是不变的;然后,基于资源分配过程中的不变特性,定义了资源使用时的接口描述,提出了适应资源动态变化的分布资源的组织模型和动态资源分配计算模型;研究了支持上述模型的系

  9. A Remarkable Angular Distribution of the Intermediate Subclass of $\\gamma$-Ray Bursts

    CERN Document Server

    Mészáros, A; Horváth, I L; Balázs, L; Vavrek, R; Meszaros, Attila; Bagoly, Zsolt; Horvath, Istvan; Balazs, Lajos G.

    2000-01-01

    In the article a test is developed, which allows to test the null-hypothesis of the intrinsic randomness in the angular distribution of gamma-ray bursts collected at the Current BATSE Catalog. The method is a modified version of the well-known counts-in-cells test, and fully eliminates the non-uniform sky-exposure function of BATSE instrument. Applying this method to the case of all gamma-ray bursts no intrinsic non-randomness was found. The test also did not find intrinsic non-randomnesses for the short and long gamma-ray bursts, respectively. On the other hand, using the method to the new intermediate subclass of gamma-ray bursts, the null-hypothesis of the intrinsic randomness for 181 intermediate gamma-ray bursts is rejected on the 96.4% confidence level. Taking 92 dimmer bursts from this subclass itself, we obtain the surprising result: This "dim" subclass of the intermediate subclass has an intrinsic non-randomness on the 99.3% confidence level. On the other hand, the 89 "bright" GRBs show no intrinsic ...

  10. Standard Test Method for Measuring the Curved Beam Strength of a Fiber-Reinforced Polymer-Matrix Composite - (View Full Text) D6416/D6416M-01(2007) Standard Test Method for Two-Dimensional Flexural Properties of Simply Supported Sandwich Composite Plates Subjected to a Distributed Load

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2001-01-01

    Standard Test Method for Measuring the Curved Beam Strength of a Fiber-Reinforced Polymer-Matrix Composite - (View Full Text) D6416/D6416M-01(2007) Standard Test Method for Two-Dimensional Flexural Properties of Simply Supported Sandwich Composite Plates Subjected to a Distributed Load

  11. Supporting Info

    Data.gov (United States)

    U.S. Environmental Protection Agency — Supporting Information. This dataset is associated with the following publication: Washington , J., T. Jenkins, and E. Weber. Identification of Unsaturated and 2H...

  12. Supporting Info

    Data.gov (United States)

    U.S. Environmental Protection Agency — Supporting Info. This dataset is associated with the following publication: Washington , J., and T. Jenkins. Abiotic Hydrolysis of Fluorotelomer-Based Polymers as a...

  13. Supporting Information

    Data.gov (United States)

    U.S. Environmental Protection Agency — This is the supporting information for the journal article. This dataset is associated with the following publication: Rankin, K., S. Mabury, T. Jenkins, and J....

  14. Internet-based support programs to alleviate psychosocial and physical symptoms in cancer patients: a literature analysis.

    Science.gov (United States)

    Bouma, Grietje; Admiraal, Jolien M; de Vries, Elisabeth G E; Schröder, Carolien P; Walenkamp, Annemiek M E; Reyners, Anna K L

    2015-07-01

    In this review the effect of internet-based support programs on psychosocial and physical symptoms resulting from cancer diagnosis and treatment is analyzed. Selection of studies was based on the following criteria: (non-)randomized controlled trials, performed in adult cancer patients, comparing quantitative psychosocial and/or physical outcomes of an internet-based support program with (a) comparison group(s). Literature search yielded 2032 studies of which 16 fulfilled the eligibility criteria. Three different internet-based support programs were identified: social support groups, online therapy for psychosocial/physical symptoms, and online systems integrating information, support, and coaching services. Outcomes improved by these programs in nine studies. Especially fatigue, social support, and distress improved, regardless of the program type. All online systems showed positive effects, mainly for social support and quality of life. This analysis indicates that internet-based support programs are effective in improving psychosocial and physical symptoms in cancer patients.

  15. Distribution Structures

    NARCIS (Netherlands)

    Friedrich, H.; Tavasszy, L.A.; Davydenko, I.

    2013-01-01

    Distribution structures are important elements of the freight transportation system. Goods are routed via warehouses on their way from production to consumption. This chapter discusses drivers behind these structures, logistics decisions connected to distribution structures on the micro level, and

  16. Distributed plot-making

    DEFF Research Database (Denmark)

    Jensen, Lotte Groth; Bossen, Claus

    2016-01-01

    different socio-technical systems (paper-based and electronic patient records). Drawing on the theory of distributed cognition and narrative theory, primarily inspired by the work done within health care by Cheryl Mattingly, we propose that the creation of overview may be conceptualised as ‘distributed plot......-making’. Distributed cognition focuses on the role of artefacts, humans and their interaction in information processing, while narrative theory focuses on how humans create narratives through the plot construction. Hence, the concept of distributed plot-making highlights the distribution of information processing...... between different social actors and artefacts, as well as the filtering, sorting and ordering of such information into a narrative that is made coherent by a plot. The analysis shows that the characteristics of paper-based and electronic patient records support or obstruct the creation of overview in both...

  17. Distributed Analysis in CMS

    CERN Document Server

    Fanfani, Alessandra; Sanches, Jose Afonso; Andreeva, Julia; Bagliesi, Giusepppe; Bauerdick, Lothar; Belforte, Stefano; Bittencourt Sampaio, Patricia; Bloom, Ken; Blumenfeld, Barry; Bonacorsi, Daniele; Brew, Chris; Calloni, Marco; Cesini, Daniele; Cinquilli, Mattia; Codispoti, Giuseppe; D'Hondt, Jorgen; Dong, Liang; Dongiovanni, Danilo; Donvito, Giacinto; Dykstra, David; Edelmann, Erik; Egeland, Ricky; Elmer, Peter; Eulisse, Giulio; Evans, Dave; Fanzago, Federica; Farina, Fabio; Feichtinger, Derek; Fisk, Ian; Flix, Josep; Grandi, Claudio; Guo, Yuyi; Happonen, Kalle; Hernandez, Jose M; Huang, Chih-Hao; Kang, Kejing; Karavakis, Edward; Kasemann, Matthias; Kavka, Carlos; Khan, Akram; Kim, Bockjoo; Klem, Jukka; Koivumaki, Jesper; Kress, Thomas; Kreuzer, Peter; Kurca, Tibor; Kuznetsov, Valentin; Lacaprara, Stefano; Lassila-Perini, Kati; Letts, James; Linden, Tomas; Lueking, Lee; Maes, Joris; Magini, Nicolo; Maier, Gerhild; McBride, Patricia; Metson, Simon; Miccio, Vincenzo; Padhi, Sanjay; Pi, Haifeng; Riahi, Hassen; Riley, Daniel; Rossman, Paul; Saiz, Pablo; Sartirana, Andrea; Sciaba, Andrea; Sekhri, Vijay; Spiga, Daniele; Tuura, Lassi; Vaandering, Eric; Vanelderen, Lukas; Van Mulders, Petra; Vedaee, Aresh; Villella, Ilaria; Wicklund, Eric; Wildish, Tony; Wissing, Christoph; Wurthwein, Frank

    2009-01-01

    The CMS experiment expects to manage several Pbytes of data each year during the LHC programme, distributing them over many computing sites around the world and enabling data access at those centers for analysis. CMS has identified the distributed sites as the primary location for physics analysis to support a wide community with thousands potential users. This represents an unprecedented experimental challenge in terms of the scale of distributed computing resources and number of user. An overview of the computing architecture, the software tools and the distributed infrastructure is reported. Summaries of the experience in establishing efficient and scalable operations to get prepared for CMS distributed analysis are presented, followed by the user experience in their current analysis activities.

  18. Distributed computing

    CERN Document Server

    Van Renesse, R

    1991-01-01

    This series will start with an introduction to distributed computing systems. Distributed computing paradigms will be presented followed by a discussion on how several important contemporary distributed operating systems use these paradigms. Topics will include processing paradigms, storage paradigms, scalability and robustness. Throughout the course everything will be illustrated by modern distributed systems notably the Amoeba distributed operating system of the Free University in Amsterdam and the Plan 9 operating system of AT&T Bell Laboratories. Plan 9 is partly designed and implemented by Ken Thompson, the main person behind the successful UNIX operating system.

  19. 附着体类型对种植支持可摘局部义齿应力分布的影响%Influence of attachment type on stress distribution of implant-supported removable partial dentures

    Institute of Scientific and Technical Information of China (English)

    杨雪; 荣起国; 杨亚东

    2015-01-01

    Objective: To compare influences of different retention attachments on stress among supporting structures .Methods: By 3-dimensional laser scanner and reverse engineering computer aided design ( CAD) software , a basic partially edentulous digital model with mandibular premolar and molar missing was established .Implant attachment and removable partial dentures ( RPD) were added into the basic model to build three kinds of models: RPD only, RPD +implant +Locator attachment , and RPD +implant +Magfit attachment .Vertical and inclined loads were put on artificial teeth unilaterally . By means of 3-dimensional finite element analysis , the stress distribution and displacement of the main supportive structures were compared . Results: A complete 3-dimensional finite element model was established , which contained tooth structure , and periodontal structures .The displacement of the denture was smaller in Locator (9.38μm vertically, 45.48μm obliquely) and Magfit models (9.54μm vertically, 39.45 μm obliquely) compared with non-implant RPD model (95.27 μm vertically, 155.70 μm oblique-ly) .Compared with the two different attachments , cortical bone stress value was higher in Locator model ( Locator model 10.850 MPa vertically , 43.760 MPa obliquely;Magfit model 7.100 MPa vertically , 19.260 MPa obliquely).The stress value of abutment periodontal ligamentin Magfit model (0.420 MPa vertically) was lower than that in Locator model (0.520 MPa vertically).Conclusion:The existence of implant could reduce maximum von Mises value of each supportive structure when Kennedy Ⅰpartially edentulous mandible was restored .Comparing the structure of Magfit and Locator attachment , the contact of Magfit attachment was rigid , while Locator was resilient .Locator attachment could improve stability of the denture dramatical -ly.Locator had stronger effect on defending horizontal movement of the denture .%目的:研究种植支持可摘局部义齿修复下颌远中游离端缺失

  20. Supporting ATLAS

    CERN Multimedia

    maximilien brice

    2003-01-01

    Eighteen feet made of stainless steel will support the barrel ATLAS detector in the cavern at Point 1. In total, the ATLAS feet system will carry approximately 6000 tons, and will give the same inclination to the detector as the LHC accelerator.

  1. Evaluating the effectiveness of a clinical practice change intervention in increasing clinician provision of preventive care in a network of community-based mental health services: a study protocol of a non-randomized, multiple baseline trial

    OpenAIRE

    2013-01-01

    Background People with a mental illness experience substantial disparities in health, including increased rates of morbidity and mortality caused by potentially preventable chronic diseases. One contributing factor to such disparity is a higher prevalence of modifiable health risk behaviors, such as smoking, inadequate fruit and vegetable intake, harmful alcohol consumption, and inadequate physical activity. Evidence supports the effectiveness of preventive care in reducing such risks, and gu...

  2. Statistical distributions

    CERN Document Server

    Forbes, Catherine; Hastings, Nicholas; Peacock, Brian J.

    2010-01-01

    A new edition of the trusted guide on commonly used statistical distributions Fully updated to reflect the latest developments on the topic, Statistical Distributions, Fourth Edition continues to serve as an authoritative guide on the application of statistical methods to research across various disciplines. The book provides a concise presentation of popular statistical distributions along with the necessary knowledge for their successful use in data modeling and analysis. Following a basic introduction, forty popular distributions are outlined in individual chapters that are complete with re

  3. Temperature and salinity profiles from CTD casts from the VALKIRIYA and other PLATFORMS from a World-Wide Distribution in support of the Integrated Global Ocean Services System (IGOSS) from 01 January 1991 to 31 January 1991 (NODC Accession 9100035)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from the VALKIRIYA and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were collected by US...

  4. Temperature and salinity profiles from CTD casts from the PARIZEAU and other PLATFORMS from a World-Wide distribution in support of the Integrated Global Ocean Services System (IGOSS) from 01 October 1988 to 31 October 1988 (NODC Accession 8800296)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from the PARIZEAU and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were collected by US...

  5. Temperature and salinity profiles from CTD casts from the VALDIVIA and other PLATFORMS from a World-Wide Distribution in support of the Integrated Global Ocean Services System (IGOSS) from 01 April 1991 to 30 April 1991 (NODC Accession 9100087)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from the VALDIVIA and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were collected by US...

  6. Temperature and salinity profiles from CTD casts from the ARGOS and other PLATFORMS from a World-Wide Distribution in support of the Integrated Global Ocean Services System (IGOSS) from 01 November 1989 to 30 November 1989 (NODC Accession 8900297)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from the ARGOS and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were collected by US...

  7. Thermally stable nanoparticles on supports

    Science.gov (United States)

    Roldan Cuenya, Beatriz; Naitabdi, Ahmed R.; Behafarid, Farzad

    2012-11-13

    An inverse micelle-based method for forming nanoparticles on supports includes dissolving a polymeric material in a solvent to provide a micelle solution. A nanoparticle source is dissolved in the micelle solution. A plurality of micelles having a nanoparticle in their core and an outer polymeric coating layer are formed in the micelle solution. The micelles are applied to a support. The polymeric coating layer is then removed from the micelles to expose the nanoparticles. A supported catalyst includes a nanocrystalline powder, thin film, or single crystal support. Metal nanoparticles having a median size from 0.5 nm to 25 nm, a size distribution having a standard deviation .ltoreq.0.1 of their median size are on or embedded in the support. The plurality of metal nanoparticles are dispersed and in a periodic arrangement. The metal nanoparticles maintain their periodic arrangement and size distribution following heat treatments of at least 1,000.degree. C.

  8. Distribution center

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    Distribution center is a logistics link fulfill physical distribution as its main functionGenerally speaking, it's a large and hiahly automated center destined to receive goods from various plants and suppliers,take orders,fill them efficiently,and deliver goods to customers as quickly as possible.

  9. Use of electronic health records to support smoking cessation.

    Science.gov (United States)

    Boyle, Raymond; Solberg, Leif; Fiore, Michael

    2014-12-30

    Health information systems such as electronic health records (EHR), computerized decision support systems, and electronic prescribing are potentially valuable components to improve the quality and efficiency of clinical interventions for tobacco use. To assess the effectiveness of electronic health record-facilitated interventions on smoking cessation support actions by clinicians, clinics, and healthcare delivery systems and on patient smoking cessation outcomes. We searched the Cochrane Tobacco Addiction Group Specialised Register, CENTRAL, MEDLINE, EMBASE, PsycINFO, CINAHL, and reference lists and bibliographies of included studies. We searched for studies published between January 1990 and July 2014. We included both randomized studies and non-randomized studies that reported interventions targeting tobacco use through an EHR in healthcare settings. The intervention could include any use of an EHR to improve smoking status documentation or cessation assistance for patients who use tobacco, either by direct action or by feedback of clinical performance measures. Characteristics and content of the interventions, participants, outcomes and methods of the included studies were extracted by one author and checked by a second. Because of wide variation in measurement of outcomes, we were not able to conduct a meta-analysis. We included six group randomized trials, one patient randomized study, and nine non-randomized observational studies of fair to good quality that tested the use of an existing EHR to improve documentation and/or treatment of tobacco use. None of the studies included a direct assessment of patient quit rates. Overall, these studies found only modest improvements in some of the recommended clinician actions on tobacco use. Documentation of tobacco status and referral to cessation counselling appears to increase following EHR modifications designed to prompt the recording and treating of tobacco use at healthcare visits. There is a need for

  10. Capacity of Distribution Feeders for Hosting Distributed Energy Resources

    DEFF Research Database (Denmark)

    Papathanassiou, S.; Hatziargyriou, N.; Anagnostopoulos, P.

    The last two decades have seen an unprecedented development of distributed energy resources (DER) all over the world. Several countries have adopted a variety of support schemes (feed-in tariffs, green certificates, direct subsidies, tax exemptions etc.) so as to promote distributed generation (DG...

  11. Time to tackle the incumbency advantage in science: A survey of scientists shows strong support for funding policies that would distribute funds more evenly among laboratories and thereby benefit new and smaller research groups

    OpenAIRE

    Ballabeni, Andrea; Hemenway, David; Scita, Giorgio

    2016-01-01

    The fact that larger, well‐established labs have more success securing research grants creates an unfair situation for younger researchers. A survey shows that many scientists favour alternative funding schemes that would distribute grant money more equally or based on the merit of the individual.

  12. Distributed Energy Generation for Climate Resilience

    Energy Technology Data Exchange (ETDEWEB)

    Stout, Sherry; Hotchkiss, Eliza

    2017-05-24

    Distributed generation can play a critical role in supporting climate adaptation goals. This infographic style poster will showcase the role of distributed generation in achieving a wide range of technical and policy goals and social services associated with climate adaptation.

  13. Supporting ATLAS

    CERN Multimedia

    2003-01-01

    Eighteen feet made of stainless steel will support the barrel ATLAS detector in the cavern at Point 1. In total, the ATLAS feet system will carry approximately 6000 tons, and will give the same inclination to the detector as the LHC accelerator. The installation of the feet is scheduled to finish during January 2004 with an installation precision at the 1 mm level despite their height of 5.3 metres. The manufacture was carried out in Russia (Company Izhorskiye Zavody in St. Petersburg), as part of a Russian and JINR Dubna in-kind contribution to ATLAS. Involved in the installation is a team from IHEP-Protvino (Russia), the ATLAS technical co-ordination team at CERN, and the CERN survey team. In all, about 15 people are involved. After the feet are in place, the barrel toroid magnet and the barrel calorimeters will be installed. This will keep the ATLAS team busy for the entire year 2004.

  14. MAIL DISTRIBUTION

    CERN Multimedia

    Mail Office

    2001-01-01

    PLEASE NOTE: changed schedule for mail distribution on 21 December 2001 afternoon delivery will be one hour earlier than usual, delivery to LHC sites will take place late morning. Thank you for your understanding.

  15. Stable distributions

    CERN Document Server

    Janson, Svante

    2011-01-01

    We give some explicit calculations for stable distributions and convergence to them, mainly based on less explicit results in Feller (1971). The main purpose is to provide ourselves with easy reference to explicit formulas. (There are no new results.)

  16. Spatial distribution

    DEFF Research Database (Denmark)

    Borregaard, Michael Krabbe; Hendrichsen, Ditte Katrine; Nachman, Gøsta Støger

    2008-01-01

    Living organisms are distributed over the entire surface of the planet. The distribution of the individuals of each species is not random; on the contrary, they are strongly dependent on the biology and ecology of the species, and vary over different spatial scale. The structure of whole...... populations reflects the location and fragmentation pattern of the habitat types preferred by the species, and the complex dynamics of migration, colonization, and population growth taking place over the landscape. Within these, individuals are distributed among each other in regular or clumped patterns......, depending on the nature of intraspecific interactions between them: while the individuals of some species repel each other and partition the available area, others form groups of varying size, determined by the fitness of each group member. The spatial distribution pattern of individuals again strongly...

  17. Market Sentiments Distribution Law

    Directory of Open Access Journals (Sweden)

    Jorge Reyes-Molina

    2016-09-01

    Full Text Available The Stock Exchange is basically ruled by the extreme market sentiments of euphoria and fear. The type of sentiment is given by the color of the candlestick (white = bullish sentiments, black = bearish sentiments, meanwhile the intensity of the sentiment is given by the size of it. In this paper you will see that the intensity of any sentiment is astonishingly distributed in a robust, systematic and universal way, according to a law of exponential decay, the conclusion of which is supported by the analysis of the Lyapunov exponent, the information entropy and the frequency distribution of candlestick size.

  18. THERMAL DISTRIBUTION SYSTEM EXPERIMENT

    Energy Technology Data Exchange (ETDEWEB)

    KRAJEWSKI,R.F.; ANDREWS,J.W.; WEI,G.

    1999-09-01

    A laboratory experiment has been conducted which tests for the effects of distribution system purging on system Delivery Effectiveness (DE) as defined in ASHRAE 152P. The experiment is described in its configuration, instrumentation, and data acquisition system. Data gathered in the experiment is given and discussed. The results show that purging of the distribution system alone does not offer any improvement of the system DE. Additional supporting tests were conducted regarding experimental simulations of buffer zones and bare pipe and are also discussed.

  19. Distributed optimality

    OpenAIRE

    Trommer, Jochen

    2005-01-01

    In dieser Dissertation schlage ich eine Synthese (Distributed Optimality, DO) von Optimalitätstheorie und einem derivationellen, morphologischem Asatz, Distributed Morphology (DM; Halle & Marantz, 1993) vor. Durch die Integration von OT in DM wird es möglich, Phänomene, die in DM durch sprachspezifische Regeln oder Merkmale von lexikalischen Einträge erfasst werden, auf die Interaktion von verletzbaren, universellen Constraints zurückzuführen. Andererseits leistet auch DM zwei substantielle B...

  20. Distributed Subtyping

    OpenAIRE

    Baehni, Sébastien; Barreto, Joao; Guerraoui, Rachid

    2006-01-01

    One of the most frequent operations in object-oriented programs is the "instanceof" test, also called the "subtyping" test or the "type inclusion" test. This test determines if a given object is an instance of some type. Surprisingly, despite a lot of research on distributed object-oriented languages and systems, almost no work has been devoted to the implementation of this test in a distributed environment. This paper presents the first algorithm to implement the "subtyping" test on an obje...

  1. EOSDIS Customer Support Challenges

    Science.gov (United States)

    Moses, J. F.; Boquist, C. L.

    2006-05-01

    The Earth Observation System Data and Information System (EOSDIS) is a large, complex data system currently supporting over 18 operational NASA satellite missions including the flagship EOS missions: Terra, Aqua, and Aura. The observations collected by these missions are kept at geographically distributed data centers. EOSDIS manages over four petabytes of data accessed by over 200,000 distinct users last year. The data centers distributed more than 37 million Earth science data products during 2005 to a diverse customer community. An important goal for these data centers is to provide an adequate service at a uniform level for the user community to ensure we get the most benefit from our investment in space resources. This paper discusses the challenges, the ways the data centers coordinate among themselves to provide service, and recent results of measuring customer satisfaction with this service.

  2. Radon transformation on reductive symmetric spaces:Support theorems

    DEFF Research Database (Denmark)

    Kuit, Job Jacob

    2013-01-01

    thus obtained can be extended to a large class of distributions containing the rapidly decreasing smooth functions and the compactly supported distributions. For these transforms we derive support theorems in which the support of ϕ is (partially) characterized in terms of the support of RPϕ. The proof...

  3. Business process support

    Energy Technology Data Exchange (ETDEWEB)

    Carle, Adriana; Fiducia, Daniel [Transportadora de Gas del Sur S.A. (TGS), Buenos Aires (Argentina)

    2005-07-01

    This paper is about the own development of business support software. The developed applications are used to support two business processes: one of them is the process of gas transportation and the other is the natural gas processing. This software has interphases with the ERP SAP, software SCADA and on line gas transportation simulation software. The main functionalities of the applications are: entrance on line real time of clients transport nominations, transport programming, allocation of the clients transport nominations, transport control, measurements, balanced pipeline, allocation of gas volume to the gas processing plants, calculate of product tons processed in each plant and tons of product distributed to clients. All the developed software generates information to the internal staff, regulatory authorities and clients. (author)

  4. USACE AIS Transmit Technical Support Summary Report

    Science.gov (United States)

    2014-09-01

    USACE AIS Transmit Technical Support Summary Report Distribution Statement A: Approved for public release; distribution is unlimited...September 2014 Report No. CD-D-09-15 USACE AIS Transmit Technical Support Summary Report ii UNCLAS//Public | CG-926 RDC | I. Gonin et al. Public...States Coast Guard Research & Development Center 1 Chelsea Street New London, CT 06320 USACE AIS Transmit Technical Support Summary Report

  5. Fuel distribution

    Energy Technology Data Exchange (ETDEWEB)

    Tison, R.R.; Baker, N.R.; Blazek, C.F.

    1979-07-01

    Distribution of fuel is considered from a supply point to the secondary conversion sites and ultimate end users. All distribution is intracity with the maximum distance between the supply point and end-use site generally considered to be 15 mi. The fuels discussed are: coal or coal-like solids, methanol, No. 2 fuel oil, No. 6 fuel oil, high-Btu gas, medium-Btu gas, and low-Btu gas. Although the fuel state, i.e., gas, liquid, etc., can have a major impact on the distribution system, the source of these fuels (e.g., naturally-occurring or coal-derived) does not. Single-source, single-termination point and single-source, multi-termination point systems for liquid, gaseous, and solid fuel distribution are considered. Transport modes and the fuels associated with each mode are: by truck - coal, methanol, No. 2 fuel oil, and No. 6 fuel oil; and by pipeline - coal, methane, No. 2 fuel oil, No. 6 oil, high-Btu gas, medium-Btu gas, and low-Btu gas. Data provided for each distribution system include component makeup and initial costs.

  6. Damage Distributions

    DEFF Research Database (Denmark)

    Lützen, Marie

    2001-01-01

    the damage location, the damage sizes and the main particulars of the struck vessel. From the numerical simulation and the analyse of the damage statistics it is found that the current formulation from the IMO SLF 43/3/2 can be used as basis for determination of the p-, r-, and v-factors. Expressions...... and methods of calculation have been discussed. The damage distributions for the different vessels have been compared and analyses regarding relations between damage parameters and main particulars have been performed. The damage statistics collected in work package 1 have been analysed for relations between...... for the distribution of the non-dimensional damage location, the non-dimensional damage length and the non-dimensional penetrations have been derived. These distributions have been used as basis for a proposal for the p- and r-factors. Two proposals for the v-factor have been performed using the damage statistics...

  7. Distributed creativity

    DEFF Research Database (Denmark)

    Glaveanu, Vlad Petre

    used within the literature and yet it has the potential to revolutionise the way we think about creativity, from how we define and measure it to what we can practically do to foster and develop creativity. Drawing on cultural psychology, ecological psychology and advances in cognitive science......This book challenges the standard view that creativity comes only from within an individual by arguing that creativity also exists ‘outside’ of the mind or more precisely, that the human mind extends through the means of action into the world. The notion of ‘distributed creativity’ is not commonly......, this book offers a basic framework for the study of distributed creativity that considers three main dimensions of creative work: sociality, materiality and temporality. Starting from the premise that creativity is distributed between people, between people and objects and across time, the book reviews...

  8. Distributed Logics

    Science.gov (United States)

    2014-10-03

    that must be woven into proofs of security statements. 03-10-2014 Memorandum Report Logic System-on-a-Chip Distributed systems 9888 ASDR&EAssistant...can be removed without damaging the logic. For all propositional letters p, E1. p ⊃ [r] p From now on, a distributed logic contains at least the...a ∈ x iff 〈h〉 ∈ x. These same definitions work for the canonical relation R for r : h y k where now a ∈ MA(k), [r] a, 〈r〉 a ∈ MA(h), x ∈ CF(h), and

  9. Decision support in the natural gas distribution process of the Ceara state, Brazil; Apoio a decisao no processo de distribucao do gas natural no ambito do estado do Ceara

    Energy Technology Data Exchange (ETDEWEB)

    Rabelo, Clarice Augusta Carvalho; Arruda, Joao Bosco Furtado; Nobre Junior, Ernesto Ferreira [Ceara Univ., Fortaleza, CE (Brazil). Dept. de Engenharia de Transportes. Nucleo de Pesquisa em Logistica, Transporte e Desenvolvimento (NUPELTD)]. E-mail: claricerabelo@aol.com; barruda@det.ufc.br; nobre@det.ufc.br

    2003-07-01

    The participation of natural gas has improved more and more in Brazilian energetic die. In Ceara, the use of natural gas has increased a lot and the expectations are the best. However it's necessary to guarantee a better infrastructure of distribution and interaction among the actors of the sector. This paper is part of a bigger project that intends to contribute with this improvement through an application of multicriteria techniques in the natural gas distribution process in Ceara. The aim of the project is to choose the market segment to be prioritized due to a possible context of restriction of gas offer in order of its potential demands. Nowadays paper, however, only makes a quick analysis of the actual gas situation in Ceara and a small explanation about multicriteria techniques, specifically, the analytic hierarchy process (AHP). Besides, through a simulation of the problem and an application of the analytic hierarchy process, this paper intends to demonstrate the applicability of these methods in this problem. (author)

  10. Network Regulation and Support Schemes

    DEFF Research Database (Denmark)

    Ropenus, Stephanie; Schröder, Sascha Thorsten; Jacobsen, Henrik

    2009-01-01

    -in tariffs to market-based quota systems, and network regulation approaches, comprising rate-of-return and incentive regulation. National regulation and the vertical structure of the electricity sector shape the incentives of market agents, notably of distributed generators and network operators....... This article seeks to investigate the interactions between the policy dimensions of support schemes and network regulation and how they affect the deployment of distributed generation. Firstly, a conceptual analysis examines how the incentives of the different market agents are affected. In particular......, it will be shown that there frequently exists a trade-off between the creation of incentives for distributed generators and for distribution system operators to facilitate the integration of distributed generation. Secondly, the interaction of these policy dimensions is analyzed, including case studies based...

  11. Network Regulation and Support Schemes

    DEFF Research Database (Denmark)

    Ropenus, Stephanie; Schröder, Sascha Thorsten; Jacobsen, Henrik

    2009-01-01

    -in tariffs to market-based quota systems, and network regulation approaches, comprising rate-of-return and incentive regulation. National regulation and the vertical structure of the electricity sector shape the incentives of market agents, notably of distributed generators and network operators....... This article seeks to investigate the interactions between the policy dimensions of support schemes and network regulation and how they affect the deployment of distributed generation. Firstly, a conceptual analysis examines how the incentives of the different market agents are affected. In particular......, it will be shown that there frequently exists a trade-off between the creation of incentives for distributed generators and for distribution system operators to facilitate the integration of distributed generation. Secondly, the interaction of these policy dimensions is analyzed, including case studies based...

  12. Digital data in support of studies and assessments of coal and petroleum resources in the Appalachian basin: Chapter I.1 in Coal and petroleum resources in the Appalachian basin: distribution, geologic framework, and geochemical character

    Science.gov (United States)

    Trippi, Michael H.; Kinney, Scott A.; Gunther, Gregory; Ryder, Robert T.; Ruppert, Leslie F.; Ruppert, Leslie F.; Ryder, Robert T.

    2014-01-01

    The Appalachian basin is a mature basin containing abundant oil, gas, and coal resources. Its fossil-fuel-bearing strata range in age from Cambrian to Permian and extend over the States of New York, Pennsylvania, Maryland, Ohio, West Virginia, Virginia, Kentucky, Tennessee, Georgia, and Alabama. The basin has provided abundant fossil fuels to support the Nation’s economic growth for at least 150 years and U.S. Geological Survey (USGS) assessments suggest that substantial untapped resources remain. A merger of new and old geologic data and ideas is required to locate and extract those remaining resources.

  13. Digital data in support of studies and assessments of coal and petroleum resources in the Appalachian basin: Chapter I.1 in Coal and petroleum resources in the Appalachian basin: distribution, geologic framework, and geochemical character

    Science.gov (United States)

    Trippi, Michael H.; Kinney, Scott A.; Gunther, Gregory; Ryder, Robert T.; Ruppert, Leslie F.; Ruppert, Leslie F.; Ryder, Robert T.

    2014-01-01

    The Appalachian basin is a mature basin containing abundant oil, gas, and coal resources. Its fossil-fuel-bearing strata range in age from Cambrian to Permian and extend over the States of New York, Pennsylvania, Maryland, Ohio, West Virginia, Virginia, Kentucky, Tennessee, Georgia, and Alabama. The basin has provided abundant fossil fuels to support the Nation’s economic growth for at least 150 years and U.S. Geological Survey (USGS) assessments suggest that substantial untapped resources remain. A merger of new and old geologic data and ideas is required to locate and extract those remaining resources.

  14. Distributed Computing.

    Science.gov (United States)

    Ryland, Jane N.

    1988-01-01

    The microcomputer revolution, in which small and large computers have gained tremendously in capability, has created a distributed computing environment. This circumstance presents administrators with the opportunities and the dilemmas of choosing appropriate computing resources for each situation. (Author/MSE)

  15. MAIL DISTRIBUTION

    CERN Multimedia

    J. Ferguson

    2002-01-01

    Following discussions with the mail contractor and Mail Service personnel, an agreement has been reached which permits deliveries to each distribution point to be maintained, while still achieving a large proportion of the planned budget reduction in 2002. As a result, the service will revert to its previous level throughout the Laboratory as rapidly as possible. Outgoing mail will be collected from a single collection point at the end of each corridor. Further discussions are currently in progress between ST, SPL and AS divisions on the possibility of an integrated distribution service for internal mail, stores items and small parcels, which could lead to additional savings from 2003 onwards, without affecting service levels. J. Ferguson AS Division

  16. Quasihomogeneous distributions

    CERN Document Server

    von Grudzinski, O

    1991-01-01

    This is a systematic exposition of the basics of the theory of quasihomogeneous (in particular, homogeneous) functions and distributions (generalized functions). A major theme is the method of taking quasihomogeneous averages. It serves as the central tool for the study of the solvability of quasihomogeneous multiplication equations and of quasihomogeneous partial differential equations with constant coefficients. Necessary and sufficient conditions for solvability are given. Several examples are treated in detail, among them the heat and the Schrödinger equation. The final chapter is devoted to quasihomogeneous wave front sets and their application to the description of singularities of quasihomogeneous distributions, in particular to quasihomogeneous fundamental solutions of the heat and of the Schrödinger equation.

  17. Distributed Games

    OpenAIRE

    Dov Monderer; Moshe Tennenholtz

    1997-01-01

    The Internet exhibits forms of interactions which are not captured by existing models in economics, artificial intelligence and game theory. New models are needed to deal with these multi-agent interactions. In this paper we present a new model--distributed games. In such a model each players controls a number of agents which participate in asynchronous parallel multi-agent interactions (games). The agents jointly and strategically control the level of information monitoring by broadcasting m...

  18. Distributed scheduling

    OpenAIRE

    Toptal, Ayşegül

    1999-01-01

    Ankara : Department of Industrial Engineering and the Institute of Engineering and Science of Bilkent Univ., 1999. Thesis (Master's) -- Bilkent University, 1999. Includes bibliographical references. Distributed Scheduling (DS) is a new paradigm that enables the local decisionmakers make their own schedules by considering local objectives and constraints within the boundaries and the overall objective of the whole system. Local schedules from different parts of the system are...

  19. Distributed memory compiler design for sparse problems

    Science.gov (United States)

    Wu, Janet; Saltz, Joel; Berryman, Harry; Hiranandani, Seema

    1991-01-01

    A compiler and runtime support mechanism is described and demonstrated. The methods presented are capable of solving a wide range of sparse and unstructured problems in scientific computing. The compiler takes as input a FORTRAN 77 program enhanced with specifications for distributing data, and the compiler outputs a message passing program that runs on a distributed memory computer. The runtime support for this compiler is a library of primitives designed to efficiently support irregular patterns of distributed array accesses and irregular distributed array partitions. A variety of Intel iPSC/860 performance results obtained through the use of this compiler are presented.

  20. Simultaneous topology optimization of structures and supports

    DEFF Research Database (Denmark)

    Buhl, Thomas

    2002-01-01

    The purpose of this paper is to demonstrate a method for and the benefits of simultaneously designing structure and support distribution using topology optimization. The support conditions are included in the topology optimization by introducing, a new set of design variables that represents...... cost of supports in a design domain. Other examples show that more efficient mechanisms are obtained by introducing the support conditions in the topology optimization problem....

  1. Widespread inclination shallowing in Permian and Triassic paleomagnetic data from Laurentia: Support from new paleomagnetic data from Middle Permian shallow intrusions in southern Illinois (USA) and virtual geomagnetic pole distributions

    Science.gov (United States)

    Domeier, M.; Van Der Voo, R.; Denny, F.B.

    2011-01-01

    Recent paleomagnetic work has highlighted a common and shallow inclination bias in continental redbeds. The Permian and Triassic paleomagnetic records from Laurentia are almost entirely derived from such sedimentary rocks, so a pervasive inclination error will expectedly bias the apparent polar wander path of Laurentia in a significant way. The long-standing discrepancy between the apparent polar wander paths of Laurentia and Gondwana in Permian and Triassic time may be a consequence of such a widespread data-pathology. Here we present new Middle Permian paleomagnetic data from igneous rocks and a contact metamorphosed limestone from cratonic Laurentia. The exclusively reversed Middle Permian magnetization is hosted by low-Ti titanomagnetite and pyrrhotite and yields a paleomagnetic pole at 56.3??S, 302.9??E (A95=3.8, N=6). This pole, which is unaffected by inclination shallowing, suggests that a shallow inclination bias may indeed be present in the Laurentian records. To further consider this hypothesis, we conduct a virtual geomagnetic pole distribution analysis, comparing theoretical expectations of a statistical field model (TK03.GAD) against published data-sets. This exercise provides independent evidence that the Laurentian paleomagnetic data is widely biased, likely because of sedimentary inclination shallowing. We estimate the magnitude of this error from our model results and present and discuss several alternative corrections. ?? 2011 Elsevier B.V.

  2. Software Engineering Support of the Third Round of Scientific Grand Challenge Investigations: An Earth Modeling System Software Framework Strawman Design that Integrates Cactus and UCLA/UCB Distributed Data Broker

    Science.gov (United States)

    Talbot, Bryan; Zhou, Shu-Jia; Higgins, Glenn

    2002-01-01

    One of the most significant challenges in large-scale climate modeling, as well as in high-performance computing in other scientific fields, is that of effectively integrating many software models from multiple contributors. A software framework facilitates the integration task. both in the development and runtime stages of the simulation. Effective software frameworks reduce the programming burden for the investigators, freeing them to focus more on the science and less on the parallel communication implementation, while maintaining high performance across numerous supercomputer and workstation architectures. This document proposes a strawman framework design for the climate community based on the integration of Cactus, from the relativistic physics community, and UCLA/UCB Distributed Data Broker (DDB) from the climate community. This design is the result of an extensive survey of climate models and frameworks in the climate community as well as frameworks from many other scientific communities. The design addresses fundamental development and runtime needs using Cactus, a framework with interfaces for FORTRAN and C-based languages, and high-performance model communication needs using DDB. This document also specifically explores object-oriented design issues in the context of climate modeling as well as climate modeling issues in terms of object-oriented design.

  3. Parametrization of nuclear parton distributions

    Indian Academy of Sciences (India)

    M Hirai; S Kumano; M Miyama

    2001-08-01

    Optimum nuclear parton distributions are obtained by analysing available experimental data on electron and muon deep inelastic scattering (DIS). The distributions are given at 2 = 1 GeV2 with a number of parameters, which are determined by a 2 analysis of the data. Valencequark distributions are relatively well determined at medium , but they are slightly dependent on the assumed parametrization form particularly at small . Although antiquark distributions are shadowed at small , their behavior is not obvious at medium from the 2 data. The gluon distributions could not be restricted well by the inclusive DIS data; however, the analysis tends to support the gluon shadowing at small . We provide analytical expressions and computer subroutines for calculating the nuclear parton distributions, so that other researchers could use them for applications to other high-energy nuclear reactions.

  4. Commutative monads as a theory of distributions

    DEFF Research Database (Denmark)

    Kock, Anders

    2012-01-01

    It is shown how the theory of commutative monads provides an axiomatic framework for several aspects of distribution theory in a broad sense, including probability distributions, physical extensive quantities, and Schwartz distributions of compact support. Among the particular aspects considered...... here are the notions of convolution, density, expectation, and conditional probability....

  5. Commutative monads as a theory of distributions

    DEFF Research Database (Denmark)

    Kock, Anders

    2012-01-01

    It is shown how the theory of commutative monads provides an axiomatic framework for several aspects of distribution theory in a broad sense, including probability distributions, physical extensive quantities, and Schwartz distributions of compact support. Among the particular aspects considered...... here are the notions of convolution, density, expectation, and conditional probability....

  6. Distribution switchgear

    CERN Document Server

    Stewart, Stan

    2004-01-01

    Switchgear plays a fundamental role within the power supply industry. It is required to isolate faulty equipment, divide large networks into sections for repair purposes, reconfigure networks in order to restore power supplies and control other equipment.This book begins with the general principles of the Switchgear function and leads on to discuss topics such as interruption techniques, fault level calculations, switching transients and electrical insulation; making this an invaluable reference source. Solutions to practical problems associated with Distribution Switchgear are also included.

  7. Mail distribution

    CERN Multimedia

    2007-01-01

    Please note that starting from 1 March 2007, the mail distribution and collection times will be modified for the following buildings: 6, 8, 9, 10, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 29, 69, 40, 70, 101, 102, 109, 118, 152, 153, 154, 155, 166, 167, 169, 171, 174, 261, 354, 358, 576, 579 and 580. Complementary Information on the new times will be posted on the entry doors and left in the mail boxes of each building. TS/FM Group

  8. A Non-Random Walk Down Hollywood Boulevard

    DEFF Research Database (Denmark)

    Lepori, Gabriele

    affect (i.e. grief, proxied by the death of Hollywood Walk of Fame celebrities) on people’s willingness to invest in risky assets (proxied by the daily performance of the U.S. stock market). Using a sample of 1,374 celebrity deaths over the period 1926-2009 and controlling for seasonalities, economic....../environmental factors, and market liquidity, I find that the death of popular and beloved celebrities is immediately followed by a 16 basis point increase in stock returns, which is consistent with a rise in the net demand for risky instruments. I also find evidence that the size of this celebrity-death effect...... is increasing in the popularity/media coverage of the celebrity in question, and is larger for stocks that are more affected by investor sentiment. Overall, my findings are consistent with the lab research on the affect management model, which maintains that incidental negative affect promotes risk...

  9. On Authentication with HMAC and Non-random Properties

    Science.gov (United States)

    Rechberger, Christian; Rijmen, Vincent

    MAC algorithms can provide cryptographically secure authentication services. One of the most popular algorithms in commercial applications is HMAC based on the hash functions MD5 or SHA-1. In the light of new collision search methods for members of the MD4 family including SHA-1, the security of HMAC based on these hash functions is reconsidered.

  10. The EGEE user support infrastructure

    CERN Document Server

    Antoni, Torsten

    2008-01-01

    Grid user support is a challenging task due to the distributed nature of the Grid. The variety of users and Virtual Organisations adds further to the challenge. Support requests come from Grid beginners, from users with specific applications, from site administrators, or from Grid monitoring operators. With the GGUS infrastructure, EGEE provides a portal where users can find support in their daily use of the Grid. The current use of the system shows that the goal has been achieved with success. The Grid user support model in EGEE can be captioned "regional support with central coordination". This model is realised through a support process which is clearly defined and involves all the parties that are needed to run a project-wide support service. This process is sustained by a help desk system which consists of a central platform integrated with several satellite systems belonging to the Regional Operations Centres (ROCs) and the Virtual Organisations (VOs). The central system (Global Grid User Support, GGUS)...

  11. The EGEE user support infrastructure

    CERN Document Server

    Antoni, T; Mills, A

    2007-01-01

    User support in a grid environment is a challenging task due to the distributed nature of the grid. The variety of users and VOs adds further to the challenge. One can find support requests by grid beginners, users with specific applications, site administrators, or grid monitoring operators. With the GGUS infrastructure, EGEE provides a portal where users can find support in their daily use of the grid. The current use of the system has shown that the goal has been achieved with success. The grid user support model in EGEE can be captioned ‘regional support with central coordination’. Users can submit a support request to the central GGUS service, or to their Regional Operations' Centre (ROC) or to their Virtual Organisation helpdesks. Within GGUS there are appropriate support groups for all support requests. The ROCs and VOs and the other project wide groups such as middleware groups (JRA), network groups (NA), service groups (SA) and other grid infrastructures (OSG, NorduGrid, etc.) are connected via a...

  12. Supporting analyses and assessments

    Energy Technology Data Exchange (ETDEWEB)

    Ohi, J. [National Renewable Energy Lab., Golden, CO (United States)

    1995-09-01

    Supporting analysis and assessments can provide a sound analytic foundation and focus for program planning, evaluation, and coordination, particularly if issues of hydrogen production, distribution, storage, safety, and infrastructure can be analyzed in a comprehensive and systematic manner. The overall purpose of this activity is to coordinate all key analytic tasks-such as technology and market status, opportunities, and trends; environmental costs and benefits; and regulatory constraints and opportunities-within a long-term and systematic analytic foundation for program planning and evaluation. Within this context, the purpose of the project is to help develop and evaluate programmatic pathway options that incorporate near and mid-term strategies to achieve the long-term goals of the Hydrogen Program. In FY 95, NREL will develop a comprehensive effort with industry, state and local agencies, and other federal agencies to identify and evaluate programmatic pathway options to achieve the long-term goals of the Program. Activity to date is reported.

  13. Capacity of Distribution Feeders for Hosting Distributed Energy Resources

    DEFF Research Database (Denmark)

    Papathanassiou, S.; Hatziargyriou, N.; Anagnostopoulos, P.

    The last two decades have seen an unprecedented development of distributed energy resources (DER) all over the world. Several countries have adopted a variety of support schemes (feed-in tariffs, green certificates, direct subsidies, tax exemptions etc.) so as to promote distributed generation (DG...... standards of the networks. To address this need in a timely and effective manner, simplified methodologies and practical rules of thumbs are often applied to assess the DER hosting capacity of existing distribution networks, avoiding thus detailed and time consuming analytical studies. The scope...

  14. Applying Distributed Object Technology to Distributed Embedded Control Systems

    DEFF Research Database (Denmark)

    Jørgensen, Bo Nørregaard; Dalgaard, Lars

    2012-01-01

    In this paper, we describe our Java RMI inspired Object Request Broker architecture MicroRMI for use with networked embedded devices. MicroRMI relieves the software developer from the tedious and error-prone job of writing communication protocols for interacting with such embedded devices. MicroR...... in developing control systems for distributed embedded platforms possessing severe resource restrictions.......RMI supports easy integration of high-level application specific control logic with low-level device specific control logic. Our experience from applying MicroRMI in the context of a distributed robotics control application, clearly demonstrates that it is feasible to use distributed object technology...

  15. Distributed analysis in ATLAS

    CERN Document Server

    Legger, Federica; The ATLAS collaboration

    2015-01-01

    The ATLAS experiment accumulated more than 140 PB of data during the first run of the Large Hadron Collider (LHC) at CERN. The analysis of such an amount of data for the distributed physics community is a challenging task. The Distributed Analysis (DA) system of the ATLAS experiment is an established and stable component of the ATLAS distributed computing operations. About half a million user jobs are daily running on DA resources, submitted by more than 1500 ATLAS physicists. The reliability of the DA system during the first run of the LHC and the following shutdown period has been high thanks to the continuous automatic validation of the distributed analysis sites and the user support provided by a dedicated team of expert shifters. During the LHC shutdown, the ATLAS computing model has undergone several changes to improve the analysis workflows, including the re-design of the production system, a new analysis data format and event model, and the development of common reduction and analysis frameworks. We r...

  16. Distributed Project Work

    DEFF Research Database (Denmark)

    Borch, Ole; Kirkegaard, B.; Knudsen, Morten

    1998-01-01

    Project work has been used for many years at Aalborg University to improve learning of theory and methods given in courses. In a closed environment where the students are forming a group in a single room, the interaction behaviour is more or less given from the natural life. Group work...... in a distributed fashion over the Internet needs more attention to the interaction protocol since the physical group room is not existing. The purpose in this paper is to develop a method for online project work by using the product: Basic Support for Cooperative Work (BSCV). An analysis of a well-proven protocol...... to be very precises and with success used on the second test group. Distributed project work is coming pretty soon and with little improvement in server tools, projects in different topics with a large and inhomogeneous profile of users are realistic....

  17. Approximation of distributed delays

    CERN Document Server

    Lu, Hao; Eberard, Damien; Simon, Jean-Pierre

    2010-01-01

    We address in this paper the approximation problem of distributed delays. Such elements are convolution operators with kernel having bounded support, and appear in the control of time-delay systems. From the rich literature on this topic, we propose a general methodology to achieve such an approximation. For this, we enclose the approximation problem in the graph topology, and work with the norm defined over the convolution Banach algebra. The class of rational approximates is described, and a constructive approximation is proposed. Analysis in time and frequency domains is provided. This methodology is illustrated on the stabilization control problem, for which simulations results show the effectiveness of the proposed methodology.

  18. Group Decision Process Support

    DEFF Research Database (Denmark)

    Gøtze, John; Hijikata, Masao

    1997-01-01

    Introducing the notion of Group Decision Process Support Systems (GDPSS) to traditional decision-support theorists.......Introducing the notion of Group Decision Process Support Systems (GDPSS) to traditional decision-support theorists....

  19. Global evidence on the distribution of economic profit rates

    Science.gov (United States)

    Williams, Michael A.; Baek, Grace; Park, Leslie Y.; Zhao, Wei

    2016-09-01

    Gibrat (1931) initiated the study of the distribution of firms' profit rates, suggesting the distribution was log-normal. Although initial empirical work supported that finding, a consensus has developed in the literature that the distribution of firm profit rates is best approximated by the Laplace distribution. Using a richer database than prior studies and testing for more theoretical distributions, we find that the distribution of firm profit rates is best approximated by the heavier-tailed Cauchy distribution.

  20. Infrastructure Support for Collaborative Pervasive Computing Systems

    DEFF Research Database (Denmark)

    Vestergaard Mogensen, Martin

    -blown implementation of the proposed concepts. Finally, we contribute to the Distribution Mechanisms researching epidemic protocols or gossiping as distribution protocols for pervasive environments. Presenting these four contributions to the area of infrastructure support for CPCS, this research contributes to an area...

  1. 2014 Distributed Wind Market Report

    Energy Technology Data Exchange (ETDEWEB)

    Orell, A; Foster, N.

    2015-08-01

    The cover of the 2014 Distributed Wind Market Report.According to the 2014 Distributed Wind Market Report, distributed wind reached a cumulative capacity of almost 1 GW (906 MW) in the United States in 2014, reflecting nearly 74,000 wind turbines deployed across all 50 states, Puerto Rico, and the U.S. Virgin Islands. In total, 63.6 MW of new distributed wind capacity was added in 2014, representing nearly 1,700 units and $170 million in investment across 24 states. In 2014, America's distributed wind energy industry supported a growing domestic industrial base as exports from United States-based small wind turbine manufacturers accounted for nearly 80% of United States-based manufacturers' sales.

  2. Distribution management system

    Energy Technology Data Exchange (ETDEWEB)

    Verho, P.; Kaerenlampi, M.; Pitkaenen, M.; Jaerventausta, P.; Partanen, J.

    1997-12-31

    This report comprises a general description of the results obtained in the research projects `Information system applications of a distribution control center`, `Event analysis in primary substation`, and `Distribution management system` of the EDISON research program during the years of 1993 - 1997. The different domains of the project are presented in more detail in other reports. An operational state analysis of a distribution network has been made from the control center point of view and the functions which can not be solved by a conventional SCADA system are determined. The basis for new computer applications is shown to be integration of the computer systems. The main result of the work is a distribution management system (DMS), which is an autonomous system integrated to the existing information systems, SCADA and AM/FM/GIS. The system uses a large number of modelling and computation methods and provides an extensive group of advanced functions to support the distribution network monitoring, fault management, operations planning and optimization. The development platform of the system consists of a Visual C++ programming environment, Windows NT operating system and PC. During the development the DMS has been tested in a pilot utility and it is nowadays in practical use in several Finnish utilities. The use of a DMS improves the quality and economy of power supply in many ways; the outage times can, in particular, be reduced using the system. Based on the achieved experiences some parts of the DMS reached the commercialization phase, too. Initially the commercial products were developed by a software company, Versoft Oy. At present the research results are the basis of a worldwide software product supplied by ABB Transmit Co. (orig.) EDISON Research Programme. 28 refs.

  3. DGLa:A Distributed Graphics Language

    Institute of Scientific and Technical Information of China (English)

    潘志庚; 胡冰峰; 等

    1994-01-01

    A distributed graphics programming language called DGLa is presented,which facilitates the development of distributed graphics application.Facilities for distributed programming and graphics support are included in it,It not only supports synchronous and asynchronous communication but also provides programmer with multiple control mechanism for process communication.The graphics support of DGLa is powerful,for both sequential graphics library and parallel graphics library are provided.The design consideration and implementation experience are discussed in detail in this paper.Application examples are also given.

  4. A dynamic distribution model for combat logistics

    OpenAIRE

    Gue, Kevin R.

    1999-01-01

    New warfare doctrine for the U.S. Marine Corps emphasizes small, highly mobile forces supported from the sea, rather than from large, land based supply points. The goal of logistics planners is to support these forces with as little inventory on land as possible. We show how to configure the land based distribution system over time to support a given battle plan with minimum inventory. Logistics planners could use the model to support tactical or operational decision making.

  5. Distributed Knowledge Management in Extranets

    DEFF Research Database (Denmark)

    Pedersen, Mogens Kühn; Larsen, Michael Holm

    1999-01-01

    Knowledge management exchange schemes based on symmetric incentives are rarely found in the literature. The distributed knowledge model relies upon a double loop knowledge conversion decision support system with symmetric incentives in an extranet. The model merges specific knowledge with knowledge...

  6. A distribution management system

    Energy Technology Data Exchange (ETDEWEB)

    Jaerventausta, P.; Verho, P.; Kaerenlampi, M.; Pitkaenen, M. [Tampere Univ. of Technology (Finland); Partanen, J. [Lappeenranta Univ. of Technology (Finland)

    1998-08-01

    The development of new distribution automation applications is considerably wide nowadays. One of the most interesting areas is the development of a distribution management system (DMS) as an expansion to the traditional SCADA system. At the power transmission level such a system is called an energy management system (EMS). The idea of these expansions is to provide supporting tools for control center operators in system analysis and operation planning. Nowadays the SCADA is the main computer system (and often the only) in the control center. However, the information displayed by the SCADA is often inadequate, and several tasks cannot be solved by a conventional SCADA system. A need for new computer applications in control center arises from the insufficiency of the SCADA and some other trends. The latter means that the overall importance of the distribution networks is increasing. The slowing down of load-growth has often made network reinforcements unprofitable. Thus the existing network must be operated more efficiently. At the same time larger distribution areas are for economical reasons being monitored at one control center and the size of the operation staff is decreasing. The quality of supply requirements are also becoming stricter. The needed data for new applications is mainly available in some existing systems. Thus the computer systems of utilities must be integrated. The main data source for the new applications in the control center are the AM/FM/GIS (i.e. the network database system), the SCADA, and the customer information system (CIS). The new functions can be embedded in some existing computer system. This means a strong dependency on the vendor of the existing system. An alternative strategy is to develop an independent system which is integrated with other computer systems using well-defined interfaces. The latter approach makes it possible to use the new applications in various computer environments, having only a weak dependency on the

  7. A distribution management system

    Energy Technology Data Exchange (ETDEWEB)

    Verho, P.; Jaerventausta, P.; Kaerenlampi, M.; Paulasaari, H. [Tampere Univ. of Technology (Finland); Partanen, J. [Lappeenranta Univ. of Technology (Finland)

    1996-12-31

    The development of new distribution automation applications is considerably wide nowadays. One of the most interesting areas is the development of a distribution management system (DMS) as an expansion of the traditional SCADA system. At the power transmission level such a system is called an energy management system (EMS). The idea of these expansions is to provide supporting tools for control center operators in system analysis and operation planning. The needed data for new applications is mainly available in some existing systems. Thus the computer systems of utilities must be integrated. The main data source for the new applications in the control center are the AM/FM/GIS (i.e. the network database system), the SCADA, and the customer information system (CIS). The new functions can be embedded in some existing computer system. This means a strong dependency on the vendor of the existing system. An alternative strategy is to develop an independent system which is integrated with other computer systems using well-defined interfaces. The latter approach makes it possible to use the new applications in various computer environments, having only a weak dependency on the vendors of the other systems. In the research project this alternative is preferred and used in developing an independent distribution management system

  8. Interactive Room Support for Complex and Distributed Design Projects

    DEFF Research Database (Denmark)

    Grønbæk, Kaj; Gundersen, Kristian Kroyer; Mogensen, Preben Holst

    2001-01-01

    We are investigating the design of digital 3D interaction technology embedded in a physical environment. We take as point of departure cemplex, collaborative industrial design projects involving heterogeneous sets of documents, and physical as well as digital 3D models. The paper introduces our n...

  9. Distributed Leadership to Support PLCs in Asian Pragmatic Singapore Schools

    Science.gov (United States)

    Hairon, Salleh; Goh, Jonathan Wee Pin; Lin, Tzu-Bin

    2014-01-01

    Nation states around the world, including Singapore, are endeavouring to reform their education systems in order to successfully compete in the global economy (Carnoy, 1999). With human capital as Singapore's primary resource, it is unsurprising that the state has placed great emphasis on strengthening the economic-education nexus. This tight…

  10. Formal Methods to Support the Design of Distributed Systems

    Science.gov (United States)

    2008-06-01

    Cam- bridge, MA, 2000. [2] M. Clavel , F. Durán, S. Eker, P. Lincoln, N. Mart́ı-Oliet, J. Meseguer, and J. Quesada. Maude: specification and...programming in rewriting logic. Theoretical Computer Science, 285, 2002. [3] M. Clavel , F. Durán, S. Eker, P. Lincoln, N. Mart́ı-Oliet, J. Meseguer. All

  11. Distributed Leadership to Support PLCs in Asian Pragmatic Singapore Schools

    Science.gov (United States)

    Hairon, Salleh; Goh, Jonathan Wee Pin; Lin, Tzu-Bin

    2014-01-01

    Nation states around the world, including Singapore, are endeavouring to reform their education systems in order to successfully compete in the global economy (Carnoy, 1999). With human capital as Singapore's primary resource, it is unsurprising that the state has placed great emphasis on strengthening the economic-education nexus. This tight…

  12. Layered distributed simulation architecture to support the C2 enterprise

    CSIR Research Space (South Africa)

    Duvenhage, A

    2009-09-01

    Full Text Available &S research as well as an extensive literature review. The requirements were also checked against a UML Use Case diagram for the framework. 3.1 Interoperability with C2 Systems To function within the C2 enterprise the framework should enable... registers and the subscriptions other backbone objects make to these titles. Issues are also inherently generated by the backbone layer for each object in the following cases: • The backbone generates a title issue whenever an object...

  13. Advancements in Distributed Learning (ADL) Environment in Support of Transformation

    Science.gov (United States)

    2017-01-01

    the findings and transition of this technology to the Alliance: • Canada; • France; • Finland; • Italy; • Netherlands; • Norway; • Sweden ...Azerbaijan, Finland, Moldova, Romania and Sweden . 5.0 MEETINGS HELD BY RTG HFM-212 • First meeting took place in Venice, Italy June 15-16, 2010

  14. Trust Measurements Yeld Distributed Decision Support in Cloud Computing

    Directory of Open Access Journals (Sweden)

    Edna Dias Canedo

    2015-05-01

    Full Text Available This paper proposes the creation of a trust model to ensure the reliable files exchange between the users of a private cloud. To validate the proposed model, a simulation environment with the tool CloudSim was used. Its use to run the simulations of the adopted scenarios allowed us to calculate the nodes (virtual machines trust table and select those considered more reliable; identify that the metrics adopted by us directly influenced the measurement of trust in a node and verify that the trust model proposed effectively allows the selection of the most suitable machine to perform the exchange of files.

  15. Nonuniversality of compact support probability distributions in random matrix theory.

    Science.gov (United States)

    Akemann, G; Cicuta, G M; Molinari, L; Vernizzi, G

    1999-11-01

    The two-point resolvent is calculated in the large-n limit for the generalized fixed and bounded trace ensembles. It is shown to disagree with that of the canonical Gaussian ensemble by a nonuniversal part that is given explicitly for all monomial potentials V(M)=M(2p). Moreover, we prove that for the generalized fixed and bounded trace ensemble all k-point resolvents agree in the large-n limit, despite their nonuniversality.

  16. A Revised STONEMAN for Distributed Ada (Trademark) Support Environments.

    Science.gov (United States)

    1984-01-01

    MA 02154 San Diego, CA 92152 Chuck Waltrip Philip Myers Johns Hopkins University Dave Pasterchik Applied Physics Lab NRVELEX Johns Hopkins Road FLEX...Georgia Tech Atlanta, GA 30332 Reed Kotler Lockheed Missiles & Space Dick Drake 1111 Lockheed Way IBM Sunnyvale, CA 94086 Federal Systems Division 102/075

  17. 分布式Web服务在农田信息监测智能决策支持系统上应用研究%Applied Research of Distributed Web Service in Farmland Information Monitoring and Intelligent Decision Support System

    Institute of Scientific and Technical Information of China (English)

    段益群; 曾辉; 卓辉

    2015-01-01

    本文从群体智能决策支持系统中的知识库模型出发,将分布式Web服务技术植入原有决策支持系统,在此基础上增添农田信息AI逻辑判断功能、数理统计模块、人工现实功能。系统能有效解决农田信息监测过程中存在诸多结构化或非结构化问题,对即时监测农田数据精准度,减少数据冗余起到辅助作用。同时,也将为农业生产者或农业领域相关单位提供更加科学辅助决策起到一定指导价值。%Based on the knowledge base model of group intelligent decision support system, the distributed Web service was put into the existing decision support system, adding up field information AI logic function, mathematical statistics module and artificial reality function, which can solve many structured or unstructured problems in farmland information monitoring process and help improve the accuracy of real-time monitoring data and reduce data redundancy. At the same time, it would play a guiding value in providing more scientific decision support for agricultural producers or relevant units in rural fields.

  18. Dawning—1000 PROOS Distributed Operating System

    Institute of Scientific and Technical Information of China (English)

    孙凝晖; 刘文卓; 等

    1997-01-01

    PROOS is a distributed operating system running on the computing nodes of massively parallel processing computer Dawning-1000.It is an efficient and easily extendible micro kernel operating system.It supports the Intel NX message passing interface for communication.

  19. Measurement of dead time by time interval distribution method

    Science.gov (United States)

    Arkani, Mohammad; Raisali, Gholamreza

    2015-02-01

    Non-random event losses due to dead time effect in nuclear radiation detection systems distort the original Poisson process into a new type of distribution. As the characteristics of the distribution depend on physical properties of the detection system, it is possible to estimate the dead time parameters based on time interval analysis, this is the problem investigated in this work. A BF3 ionization chamber is taken as a case study to check the validity of the method in experiment. The results are compared with the data estimated by power rising experiment performed in Esfahan Heavy Water Zero Power Reactor (EHWZPR). Using Monte Carlo simulation, the problem is elaborately studied and useful range for counting rates of the detector is determined. The proposed method is accurate and applicable for all kinds of radiation detectors with no potential difficulty and no need for any especial nuclear facility. This is not a time consuming method and advanced capability of online examination during normal operation of the detection system is possible.

  20. The Folded t Distribution

    OpenAIRE

    Psarakis, Stelios; Panaretos, John

    1990-01-01

    Measurements are frequently recorder without their algebraic sign. As a consequence the underlying distribution of measurements is replaced by a distribution of absolute measurements. When the underlying distribution is t the resulting distribution is called the “folded-t distribution”. Here we study this distribution, we find the relationship between the folded-t distribution and a special case of the folded normal distribution and we derive relationships of the folded-t distribution to othe...

  1. Principles of Distributed Data Management in 2020?

    CERN Document Server

    Valduriez, Patrick

    2011-01-01

    With the advents of high-speed networks, fast commodity hardware, and the web, distributed data sources have become ubiquitous. The third edition of the \\"Ozsu-Valduriez textbook Principles of Distributed Database Systems [10] reflects the evolution of distributed data management and distributed database systems. In this new edition, the fundamental principles of distributed data management could be still presented based on the three dimensions of earlier editions: distribution, heterogeneity and autonomy of the data sources. In retrospect, the focus on fundamental principles and generic techniques has been useful not only to understand and teach the material, but also to enable an infinite number of variations. The primary application of these generic techniques has been obviously for distributed and parallel DBMS versions. Today, to support the requirements of important data-intensive applications (e.g. social networks, web data analytics, scientific applications, etc.), new distributed data management tech...

  2. Distributional assumptions in food and feed commodities- development of fit-for-purpose sampling protocols.

    Science.gov (United States)

    Paoletti, Claudia; Esbensen, Kim H

    2015-01-01

    Material heterogeneity influences the effectiveness of sampling procedures. Most sampling guidelines used for assessment of food and/or feed commodities are based on classical statistical distribution requirements, the normal, binomial, and Poisson distributions-and almost universally rely on the assumption of randomness. However, this is unrealistic. The scientific food and feed community recognizes a strong preponderance of non random distribution within commodity lots, which should be a more realistic prerequisite for definition of effective sampling protocols. Nevertheless, these heterogeneity issues are overlooked as the prime focus is often placed only on financial, time, equipment, and personnel constraints instead of mandating acquisition of documented representative samples under realistic heterogeneity conditions. This study shows how the principles promulgated in the Theory of Sampling (TOS) and practically tested over 60 years provide an effective framework for dealing with the complete set of adverse aspects of both compositional and distributional heterogeneity (material sampling errors), as well as with the errors incurred by the sampling process itself. The results of an empirical European Union study on genetically modified soybean heterogeneity, Kernel Lot Distribution Assessment are summarized, as they have a strong bearing on the issue of proper sampling protocol development. TOS principles apply universally in the food and feed realm and must therefore be considered the only basis for development of valid sampling protocols free from distributional constraints.

  3. Distributed Project Work

    DEFF Research Database (Denmark)

    Borch, Ole; Kirkegaard, B.; Knudsen, Morten

    1998-01-01

    Project work has been used for many years at Aalborg University to improve learning of theory and methods given in courses. In a closed environment where the students are forming a group in a single room, the interaction behaviour is more or less given from the natural life. Group work...... in a distributed fashion over the Internet needs more attention to the interaction protocol since the physical group room is not existing. The purpose in this paper is to develop a method for online project work by using the product: Basic Support for Cooperative Work (BSCV). An analysis of a well-proven protocol...... for information exchange in the traditional project environment is performed. A group of teachers and a student group using small project examples test the method. The first test group used a prototype for testing and found the new activity synchronization difficult to adapt, so the method was finally adjusted...

  4. Flowcharts as Technical Support

    Science.gov (United States)

    Caudill, Jason

    2007-01-01

    Any time technology is employed in an organization there is a need to provide support for the users. Such support usually needs to be offered at the location where users are trying to access the technological resources. More often than not, the user who needs the support wants to get the support immediately, not at some point in the future after a…

  5. Product Distributions for Distributed Optimization. Chapter 1

    Science.gov (United States)

    Bieniawski, Stefan R.; Wolpert, David H.

    2004-01-01

    With connections to bounded rational game theory, information theory and statistical mechanics, Product Distribution (PD) theory provides a new framework for performing distributed optimization. Furthermore, PD theory extends and formalizes Collective Intelligence, thus connecting distributed optimization to distributed Reinforcement Learning (FU). This paper provides an overview of PD theory and details an algorithm for performing optimization derived from it. The approach is demonstrated on two unconstrained optimization problems, one with discrete variables and one with continuous variables. To highlight the connections between PD theory and distributed FU, the results are compared with those obtained using distributed reinforcement learning inspired optimization approaches. The inter-relationship of the techniques is discussed.

  6. Content Distribution over IP : Developments and Challenges

    OpenAIRE

    Popescu, Adrian; Kouvatsos, Demetres; Remondo, David; Giordano, Stefano

    2006-01-01

    This chapter focuses on the multimedia distribution over Internet IP under the auspices of the NoE Euro-NGI research project "Routing in Overlay Networks (ROVER)". The multimedia distribution is supported by several components such as services, content distribution chain, protocols and standards whilst Internet is used for content, acquisition, management and delivery as well as an Internet; Protocol Television (IPTV) infrastructure with QoS facilities. As the convergence between fi...

  7. The THUDSOS Distributed Operating System

    Institute of Scientific and Technical Information of China (English)

    廖先Zhi; 刘旭峰; 等

    1991-01-01

    The THUDSOS is a distributed operating system modeled as an abstract machine which provides decentralized control,transparency,availability,and reliability,as welol as a good degree of autonomy at each node,that makes our distributed system usable.Our operating system supports transparent access to data through network wide filesystem.The simultaneous access to any device is discussed for the case when the peripherals are treated as files.This operating system allows spawning of parallel application programs to solve problems in the fields,such as numerical analysis and artificial intelligence.

  8. Social Support, Religious Involvement and Alcohol Use among Students at a Conservative Religious University.

    Science.gov (United States)

    Thompson, Wendy E

    2017-05-24

    The misuse of alcohol among college students remains a significant public health concern in the United States. Excessive drinking among college students has been linked to numerous negative consequences, including rape, impaired academic performance, absenteeism from work and school and damaged social relations. This study examined whether religious involvement and social support played a role in reducing the frequency of alcohol use. A non-random convenience sample of 364 students from a larger study of 760 college students-18 years old and older-were recruited over a 2 month period. The survey used in this study consisted of 124 items and collected information on areas such as substance misuse, sexual activity, use of pornography, relationships, personal religious practices, and social support. A descriptive analysis and chi-square were performed to determine if there was a relationship between frequency of alcohol use and gender, marital status, student class, GPA, religion, ethnicity and age. Linear regression was conducted to determine if social support and religious involvement were predictors of frequency of alcohol misuse. Multivariate regression analysis was used for predicting religious involvement when including social support while controlling for gender, age, ethnicity and grade. The present study revealed that religious involvement was a predictor for reduced frequency of alcohol use, while social support was not a predictor of lower frequency of alcohol use.

  9. Physical Effects of Distributed PV Generation on California's Distribution System

    CERN Document Server

    Cohen, Michael A

    2015-01-01

    Deployment of high-penetration photovoltaic (PV) power is expected to have a range of effects -- both positive and negative -- on the distribution grid. The magnitude of these effects may vary greatly depending upon feeder topology, climate, PV penetration level, and other factors. In this paper we present a simulation study of eight representative distribution feeders in three California climates at PV penetration levels up to 100\\%, supported by a unique database of distributed PV generation data that enables us to capture the impact of PV variability on feeder voltage and voltage regulating equipment. When comparing the influence of feeder location (i.e. climate) versus feeder type on outcomes, we find that location more strongly influences the incidence of reverse power flow, reductions in peak loading and the presence of voltage excursions. On the other hand, we find that feeder characteristics more strongly influence the magnitude of loss reduction and changes in voltage regulator operations. We find th...

  10. NRL Satellite Support for DYNAMO Field Program

    Science.gov (United States)

    2012-09-30

    1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. NRL Satellite Support for DYNAMO Field Program Jeffrey...Jeff.Hawkins@nrlmry.navy.mil Document Number: N0001412WX20870 LONG-TERM GOALS To provide the ONR-sponsored DYNAMO field program with a...the Indian Ocean. OBJECTIVES Develop a NRL-MRY near real-time web page that enables DYNAMO field program participants to view the evolving

  11. A System Supporting Qualitative Research

    Directory of Open Access Journals (Sweden)

    Emilia Todorova

    2014-11-01

    Full Text Available this paper presents a system aimed to be entirely located in the Internet. The database, server side, logic and user interface are accessible regardless the location and equipment of the working team members. The system supports qualitative analysis of large datasets, and the work can be distributed among several team members or teams. A modified mixed method for developing software projects is used, according to the peculiarities of our case, splitting the phase of code writing into two sub-phases each with different number of iterations.

  12. Superdiffusion in supported lipid bilayers

    CERN Document Server

    Campagnola, Grace; Schroder, Bryce W; Peersen, Olve B; Krapf, Diego

    2015-01-01

    We study the diffusion of membrane-targeting C2 domains using single-molecule tracking in supported lipid bilayers. The ensemble-averaged mean square displacement (MSD) exhibits superdiffusive behavior. However, the time-averaged MSD of individual trajectories is found to be linear with respect to lag time, as in Brownian diffusion. These observations are explained in terms of bulk excursions that introduce jumps with a heavy-tail distribution. Our experimental results are shown to agree with analytical models of bulk-mediated diffusion and with numerical simulations.

  13. Distributed and Parallel Component Library

    Institute of Scientific and Technical Information of China (English)

    XU Zheng-quan; XU Yang; YAN Ai-ping

    2005-01-01

    Software component library is the essential part of reuse-based software development. It is shown that making use of a single component library to store all kinds of components and from which components are searched is very inefficient. We construct multi-libraries to support software reuse and use PVM as development environments to imitate largescale computer, which is expected to fulfill distributed storage and parallel search of components efficiently and improve software reuse.

  14. Pulse Distributing Manifold; Pulse Distributing Manifold

    Energy Technology Data Exchange (ETDEWEB)

    Schutting, Eberhard [Technische Univ. Graz (Austria); Sams, Theodor [AVL List GmbH, Graz (Austria); Glensvig, Michael [Forschungsgesellschaft mbH, Graz (AT). Kompetenzzentrum ' ' Das virtuelle Fahrzeug' ' (VIF)

    2011-07-01

    The Pulse Distributing Manifold is a new charge exchange method for turbocharged diesel engines with exhaust gas recirculation (EGR). The method is characterized in that the EGR mass flow is not diverted from the exhaust gas mass flow continuously, but over time broken into sub-streams. The temporal interruption is achieved by two phase-shifted outlet valves which are connected via separate manifolds only with the turbocharger or only with the EGR path. The time points of valve opening are chosen such that the turbocharger and the aftertreatment process of exhaust gas is perfused by high-energy exhaust gas of the blowdown phase while cooler and less energy-rich exhaust gas of the exhaust period is used for the exhaust gas recirculation. This increases the enthalpy for the turbocharger and the temperature for the exhaust gas treatment, while the cooling efficiency at the EGR cooler is reduced. The elimination of the continuous EGR valve has a positive effect on pumping losses. The principle functioning and the potential of this system could be demonstrated by means of a concept study using one-dimensional simulations. Without disadvantages in fuel consumption for the considered commercial vehicle engine, a reduction the EGR cooler performance by 15 % and an increase in exhaust temperature of 35 K could be achieved. The presented charge exchange method was developed, evaluated and patented within the scope of the research program 'K2-mobility' of the project partners AVL (Mainz, Federal Republic of Germany) and University of Technology Graz (Austria). The research project 'K2-Mobility' is supported by the competence center 'The virtual vehicle' Forschungsgesellschaft mbH (Graz, Austria).

  15. Effective Suppression of Pathological Synchronization in Cortical Networks by Highly Heterogeneous Distribution of Inhibitory Connections

    Science.gov (United States)

    Kada, Hisashi; Teramae, Jun-Nosuke; Tokuda, Isao T.

    2016-01-01

    Even without external random input, cortical networks in vivo sustain asynchronous irregular firing with low firing rate. In addition to detailed balance between excitatory and inhibitory activities, recent theoretical studies have revealed that another feature commonly observed in cortical networks, i.e., long-tailed distribution of excitatory synapses implying coexistence of many weak and a few extremely strong excitatory synapses, plays an essential role in realizing the self-sustained activity in recurrent networks of biologically plausible spiking neurons. The previous studies, however, have not considered highly non-random features of the synaptic connectivity, namely, bidirectional connections between cortical neurons are more common than expected by chance and strengths of synapses are positively correlated between pre- and postsynaptic neurons. The positive correlation of synaptic connections may destabilize asynchronous activity of networks with the long-tailed synaptic distribution and induce pathological synchronized firing among neurons. It remains unclear how the cortical network avoids such pathological synchronization. Here, we demonstrate that introduction of the correlated connections indeed gives rise to synchronized firings in a cortical network model with the long-tailed distribution. By using a simplified feed-forward network model of spiking neurons, we clarify the underlying mechanism of the synchronization. We then show that the synchronization can be efficiently suppressed by highly heterogeneous distribution, typically a lognormal distribution, of inhibitory-to-excitatory connection strengths in a recurrent network model of cortical neurons. PMID:27803659

  16. Progress in characterizing submonolayer island growth: Capture-zone distributions, growth exponents, & hot precursors

    Science.gov (United States)

    Einstein, Theodore L.; Pimpinelli, Alberto; González, Diego Luis; Morales-Cifuentes, Josue R.

    2015-09-01

    In studies of epitaxial growth, analysis of the distribution of the areas of capture zones (i.e. proximity polygons or Voronoi tessellations with respect to island centers) is often the best way to extract the critical nucleus size i. For non-random nucleation the normalized areas s of these Voronoi cells are well described by the generalized Wigner distribution (GWD) Pβ(s) = asβ exp(-bs2), particularly in the central region 0.5 < s < 2 where data are least noisy. Extensive Monte Carlo simulations reveal inadequacies of our earlier mean field analysis, suggesting β = i + 2 for diffusion-limited aggregation (DLA). Since simulations generate orders of magnitude more data than experiments, they permit close examination of the tails of the distribution, which differ from the simple GWD form. One refinement is based on a fragmentation model. We also compare island-size distributions. We compare analysis by island-size distribution and by scaling of island density with flux. Modifications appear for attach-limited aggregation (ALA). We focus on the experimental system para-hexaphenyl on amorphous mica, comparing the results of the three analysis techniques and reconciling their results via a novel model of hot precursors based on rate equations, pointing out the existence of intermediate scaling regimes between DLA and ALA.

  17. Distributed Enforcement of Service Choreographies

    Directory of Open Access Journals (Sweden)

    Marco Autili

    2015-02-01

    Full Text Available Modern service-oriented systems are often built by reusing, and composing together, existing services distributed over the Internet. Service choreography is a possible form of service composition whose goal is to specify the interactions among participant services from a global perspective. In this paper, we formalize a method for the distributed and automated enforcement of service choreographies, and prove its correctness with respect to the realization of the specified choreography. The formalized method is implemented as part of a model-based tool chain released to support the development of choreography-based systems within the EU CHOReOS project. We illustrate our method at work on a distributed social proximity network scenario.

  18. Hydronic distribution system computer model

    Energy Technology Data Exchange (ETDEWEB)

    Andrews, J.W.; Strasser, J.J.

    1994-10-01

    A computer model of a hot-water boiler and its associated hydronic thermal distribution loop has been developed at Brookhaven National Laboratory (BNL). It is intended to be incorporated as a submodel in a comprehensive model of residential-scale thermal distribution systems developed at Lawrence Berkeley. This will give the combined model the capability of modeling forced-air and hydronic distribution systems in the same house using the same supporting software. This report describes the development of the BNL hydronics model, initial results and internal consistency checks, and its intended relationship to the LBL model. A method of interacting with the LBL model that does not require physical integration of the two codes is described. This will provide capability now, with reduced up-front cost, as long as the number of runs required is not large.

  19. Celiac Support Association

    Science.gov (United States)

    ... America and support CSA. Click here to start shopping! Celiac SUPPORT ASSOCIATION ® GLUTEN-FREE RESOURCE DIRECTORY These ... visit www.schwans.com and register for an online account. Orders must be placed online to be ...

  20. A support design process

    Energy Technology Data Exchange (ETDEWEB)

    Arthur, J.; Scott, P.B. [Health and Safety Executive (United Kingdom)

    2004-07-01

    A workman suffered a fatal injury due to a fall of ground from the face of a development drivage, which was supported by passive supports supplemented with roof bolts. A working party was set up to review the support process and evaluate how protection of the workmen could be improved whilst setting supports.The working party included representatives from the trade unions, the mines inspectorate and mine operators.Visits were made to several mines and discussions were held with the workmen and management at these mines. The paper describes the results of the visits and how a support design process was evolved. The process will ensure that the support system is designed to reduce the inherent hazards associated with setting supports using either conventional or mixed support systems.