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Sample records for non-myeloablative sct utilizing

  1. Targeting myeloid cells to the brain using non-myeloablative conditioning.

    Directory of Open Access Journals (Sweden)

    Chotima Böttcher

    Full Text Available Bone marrow-derived cells (BMDCs are able to colonize the central nervous system (CNS at sites of damage. This ability makes BMDCs an ideal cellular vehicle for transferring therapeutic genes/molecules to the CNS. However, conditioning is required for bone marrow-derived myeloid cells to engraft in the brain, which so far has been achieved by total body irradiation (TBI and by chemotherapy (e.g. busulfan treatment. Unfortunately, both regimens massively disturb the host's hematopoietic compartment. Here, we established a conditioning protocol to target myeloid cells to sites of brain damage in mice using non-myeloablative focal head irradiation (HI. This treatment was associated with comparatively low inflammatory responses in the CNS despite cranial radiation doses which are identical to TBI, as revealed by gene expression analysis of cytokines/chemokines such as CCL2, CXCL10, TNF-α and CCL5. HI prior to bone marrow transplantation resulted in much lower levels of blood chimerism defined as the percentage of donor-derived cells in peripheral blood ( 95% or busulfan treatment (> 50%. Nevertheless, HI effectively recruited myeloid cells to the area of motoneuron degeneration in the brainstem within 7 days after facial nerve axotomy. In contrast, no donor-derived cells were detected in the lesioned facial nucleus of busulfan-treated animals up to 2 weeks after transplantation. Our findings suggest that myeloid cells can be targeted to sites of brain damage even in the presence of very low levels of peripheral blood chimerism. We established a novel non-myeloablative conditioning protocol with minimal disturbance of the host's hematopoietic system for targeting BMDCs specifically to areas of pathology in the brain.

  2. A randomized phase II trial of tacrolimus, mycophenolate mofetil and sirolimus after non-myeloablative unrelated donor transplantation

    DEFF Research Database (Denmark)

    Kornblit, Brian; Maloney, David G; Storer, Barry E

    2014-01-01

    The study is a randomized phase II trial investigating graft-versus-host disease prophylaxis after non-myeloablative (90 mg/m(2) fludarabine and 2 Gy total body irradiation) human leukocyte antigen matched unrelated donor transplantation. Patients were randomized as follows: arm 1 - tacrolimus 18...

  3. Allogeneic stem cell transplantation using non-myeloablative conditioning regimens: results of the Mexican approach.

    Science.gov (United States)

    Ruiz-Argüelles, Guillermo J

    2002-08-01

    We have used a novel method to conduct non-myeloablative stem cell transplantation (NST), making the following changes in previous methods: Use of the cheapest conditioning drugs, tailored number of apheresis sessions in the donors, elimination of ganciclovir and IgG, outpatient conduction when possible, diminished number of transfusions of blood products and diminished number of donor lymphocyte infusions. With this method, we have prospectively conducted 70 allografts in patients with different diseases: Chronic myelogenous leukemia, acute myelogenous leukemia, acute lymphoblastic leukemia, myelodysplasia, thalassemia major, relapsed Hodgkins disease, Blackfan-Diamond syndrome and aplastic anemia. In them, the median granulocyte recovery time to 0.5 x 10(9)/L was 11 d, whereas the median platelet recovery time to 20 x 10(9)/L was 12 d. Twenty patients did not need red blood cell transfusions and 17 did not need platelet transfusions. In 55 individuals (78%), the procedure could be completed fully on an outpatient basis. Follow-up times range between 30 and 800 d.: Four patients failed to engraft and recovered endogenous hemopoiesis; 16 patients (23%) developed acute graft versus-host disease (GVHD) whereas 28 (49%) developed chronic GVHD. Thirty two patients (47%) have died: 21 with a relapsing disease and seven as a result of GVHD; the median post-trasplant survival (SV) was 420 d., whereas the 12-mo. SV was 42%. The 100-day mortality was 3.8% and the transplant-related mortality was 14.2%. The median cost of the allografts was 18,000.00 US dollars. This method could be particularly adequate in developing countries, where very few individuals can afford the cost of a conventional bone marrow transplantation procedure.

  4. ATLAS SCT Commissioning

    CERN Document Server

    Limper, Maaike

    2007-01-01

    The Barrel and End-Cap SCT detectors are installed in the ATLAS cavern. This paper will focus on the assembly, installation and first tests of the SCT in-situ. The thermal, electrical and optical services were tested and the results will be reviewed. Problems with the cooling have led to a modification for the heaters on the cooling return lines. The first tests of the SCT in-situ will be described using the calibration scans. The performance of the SCT, in particular the fraction of working channels and the noise performance, is well within the ATLAS specification.

  5. SCT Barrel Assembly Complete

    CERN Multimedia

    L. Batchelor

    As reported in the April 2005 issue of the ATLAS eNews, the first of the four Semiconductor Tracker (SCT) barrels, complete with modules and services, arrived safely at CERN in January of 2005. In the months since January, the other three completed barrels arrived as well, and integration of the four barrels into the entire barrel assembly commenced at CERN, in the SR1 building on the ATLAS experimental site, in July. Assembly was completed on schedule in September, with the addition of the innermost layer to the 4-barrel assembly. Work is now underway to seal the barrel thermal enclosure. This is necessary in order to enclose the silicon tracker in a nitrogen atmosphere and provide it with faraday-cage protection, and is a delicate and complicated task: 352 silicon module powertapes, 352 readout-fibre bundles, and over 400 Detector Control System sensors must be carefully sealed into the thermal enclosure bulkhead. The team is currently verifying the integrity of the low mass cooling system, which must be d...

  6. TRT and SCT barrels merge

    CERN Multimedia

    Wells, P S

    2006-01-01

    The SCT barrel was inserted in the TRT on 17 February, just missing Valentine's day. This was a change of emphasis for the two detectors. In the preceeding months there had been a lot of focus on testing their performance. The TRT had been observing cosmic rays through several sectors of the barrel, and all the modules on each of the four layers of the SCT had been characterised prior to integration. In parallel, the engineering teams, lead by Marco Olcese, Andrea Catinaccio, Eric Perrin, Neil Dixon, Iourii Gusakov, Gerard Barbier and Takashi Kohriki, had been preparing for this critical operation. Figure 1: Neil Dixon and Marco Olcese verifying the final alignment The two detectors had to be painstakingly aligned to be concentric to within a millimetre. The SCT was held on a temporary cantilever stand, and the TRT in the ID trolley had to inch over it. Finally the weight of the SCT was transferred to the rails on the inside of the TRT itself. The SCT services actually protruded a little outside the oute...

  7. The ATLAS semiconductor tracker (SCT)

    CERN Document Server

    Jackson, J N

    2005-01-01

    The ATLAS detector (CERN/LHCC/94-43 (1994)) is designed to study a wide range of physics at the CERN Large Hadron Collider (LHC) at luminosities up to 10**3**4 cm**-**2 s**-**1 with a bunch-crossing rate of 40 MHz. The Semiconductor Tracker (SCT) forms a key component of the Inner Detector (vol. 1, ATLAS TDR 4, CERN/LHCC 97-16 (1997); vol. 2, ATLAS TDR 5, CERN/LHCC 97-17 (1997)) which is situated inside a 2 T solenoid field. The ATLAS Semiconductor Tracker (SCT) utilises 4088 silicon modules with binary readout mounted on carbon fibre composite structures arranged in the forms of barrels in the central region and discs in the forward region. The construction of the SCT is now well advanced. The design of the SCT modules, services and support structures will be briefly outlined. A description of the various stages in the construction process will be presented with examples of the performance achieved and the main difficulties encountered. Finally, the current status of the construction is reviewed.

  8. Nonmyeloablative conditioning, unmanipulated haploidentical SCT and post-infusion CY for advanced lymphomas.

    Science.gov (United States)

    Castagna, L; Bramanti, S; Furst, S; Giordano, L; Crocchiolo, R; Sarina, B; Mauro, E; Morabito, L; Bouabdallah, R; Coso, D; Balzarotti, M; Broussais, F; El-Cheikh, J; Stella, C C; Brusamolino, E; Blaise, D; Santoro, A

    2014-12-01

    Allo-SCT is regularly performed in advanced lymphoma. Haploidentical family donors are a valuable source of hematopoietic stem cells and transplants from these donors, using T-repleted grafts, has recently been successfully reported. We report on 49 patients with refractory lymphoma who received T-repleted haploidentical SCT with a non-myeloablative regimen and post-transplant CY. The median time to recover ANC >0.5 × 10e9/L and transfusion independent plt count >20 × 10e9/L was 20 days (range 14-38) and 26 days (range 14-395). The probability to reach ANC >0.5 × 10e9/L at 30 days was 87% and transfusion independent plt count >20 × 10e9/L at 100 days was 87%. The cumulative incidence of grade 2-4 acute GVHD (aGVHD) was 25.6% (95% confidence interval (CI): 12.9-38.3%) and the cumulative incidence of chronic GVHD (cGVHD) was 5.2% (95% CI: 0-12.4%). The median follow-up is 20.6 months (range 12-54), and the projected 2-year OS and PFS were 71 and 63%. The relapse rate was 18.7% (95% CI: 7.6-29.8%) and the median time to relapse was 4.4 months (range 1.1-8.3). At 2 years, cumulative incidence of NRM was 16.3% (95% CI: 5.9-26.8%). T-repleted Haploidentical transplantation with post-infusion CY is a feasible and effective therapy in the poor prognosis of advanced lymphoma patients.

  9. Second auto-SCT for treatment of relapsed multiple myeloma.

    Science.gov (United States)

    Gonsalves, W I; Gertz, M A; Lacy, M Q; Dispenzieri, A; Hayman, S R; Buadi, F K; Dingli, D; Hogan, W J; Kumar, S K

    2013-04-01

    High-dose therapy and auto-SCT remain integral in the initial treatment of multiple myeloma (MM), and are increasingly being applied for management of relapsed disease. We examined the outcomes in 98 patients undergoing salvage auto-SCT (auto-SCT2) for relapsed MM after receiving an initial transplant (auto-SCT1) between 1994 and 2009. The median age at auto-SCT2 was 60 years (range: 35-74). The median time between auto-SCT1 and auto-SCT2 was 46 months (range: 10-130). Treatment-related mortality was seen in 4%. The median PFS from auto-SCT2 was 10.3 (95% confidence interval (CI): 7-14) months and the median OS from auto-SCT2 was 33 months (95% CI: 28-51). In a multivariable analysis, shorter time to progression (TTP) after auto-SCT1, not achieving a CR after auto-SCT2, higher number of treatment regimens before auto-SCT2 and a higher plasma cell labeling index at auto-SCT2 predicted for shorter PFS. However, only a shorter TTP after auto-SCT1 predicted for a shorter OS post auto-SCT2. Hence, auto-SCT2 is an effective and feasible therapeutic option for MM patients relapsing after other treatments, especially in patients who had a TTP of at least 12 months after their auto-SCT1.

  10. Applying systems-centered theory (SCT) and methods in organizational contexts: putting SCT to work.

    Science.gov (United States)

    Gantt, Susan P

    2013-04-01

    Though initially applied in psychotherapy, a theory of living human systems (TLHS) and its systems-centered practice (SCT) offer a comprehensive conceptual framework replete with operational definitions and methods that is applicable in a wide range of contexts. This article elaborates the application of SCT in organizations by first summarizing systems-centered theory, its constructs and methods, and then using case examples to illustrate how SCT has been used in organizational and coaching contexts.

  11. EVAPORATIVE COOLING - CONCEPTUAL DESIGN FOR ATLAS SCT

    CERN Document Server

    Niinikoski, T O

    1998-01-01

    The conceptual design of an evaporative two-phase flow cooling system for the ATLAS SCT detector is described, using perfluorinated propane (C3F8) as a coolant. Comparison with perfluorinated butane (C4F10) is made, although the detailed design is presented only for C3F8. The two-phase pressure drop and heat transfer coefficient are calculated in order to determine the dimensions of the cooling pipes and module contacts for the Barrel SCT. The region in which the flow is homogeneous is determined. The cooling cycle, pipework, compressor, heat exchangers and other main elements of the system are calculated in order to be able to discuss the system control, safety and reliability. Evaporative cooling appears to be substantially better than the binary ice system from the point of view of safety, reliability, detector thickness, heat transfer coefficient, cost and simplicity.

  12. The hatfield SCT lunar atlas photographic atlas for Meade, Celestron and other SCT telescopes

    CERN Document Server

    Cook, Jeremy

    2005-01-01

    Schmitt-Cassegrain Telescopes (SCT) and Schmitt-Maksutov telescopes - which include the best-selling models from Meade, Celestron, and other important manufacturers - reverse the visual image left for right, giving a "mirror image". This makes it extremely difficult for observers to identify lunar features at the eyepiece of one of these instruments, using conventional atlases which show the Moon "upside-down" with south at the top. The human brain just doesn't cope well with trying to compare the real thing with a map that is a mirror-image of it!The Hatfield SCT Lunar Atlas solves the problem. Photographs and the detailed key maps are exactly as the Moon appears through the eyepiece of an SCT or Maksutov telescope. Smaller IAU-standard reference photographs are included on each page, to make it simple to compare the mirrored SCT photographs and maps with those that appear in other conventional atlases.Every owner of an SCT - and that's most amateur astronomers - will want this!.

  13. Spray cryotherapy (SCT): institutional evolution of techniques and clinical practice from early experience in the treatment of malignant airway disease

    Science.gov (United States)

    Turner, J. Francis; Parrish, Scott

    2015-01-01

    Background Spray cryotherapy (SCT) was initially developed for gastroenterology (GI) endoscopic use in the esophagus. In some institutions where a device has been utilized by GI, transition to use in the airways by pulmonologists and thoracic surgeons occurred. Significant differences exist, however, in the techniques for safely using SCT in the airways. Methods We describe the early experience at Walter Reed National Military Medical Center from 2011 to 2013 using SCT in patients with malignant airway disease and the evolution of our current techniques and clinical practice patterns for SCT use in patients. In November 2013 enrollment began in a multi-institutional prospective SCT registry in which we are still enrolling and will be reported on separately. Results Twenty-seven patients that underwent 80 procedures (2.96 procedures/patient). The average age was 63 years with a range of 20 to 87 years old. The average Eastern Cooperative Oncology Group (ECOG) status was 1.26. All malignancies were advanced stage disease. All procedures were performed in the central airways. Other modalities were used in combination with SCT in 31 (39%) of procedures. Additionally 45 of the 80 (56%) procedures were performed in proximity to a silicone, hybrid, or metal stent. Three complications occurred out of the 80 procedures. All three were transient hypoxia that limited continued SCT treatments. These patients were all discharged from the bronchoscopy recovery room to their pre-surgical state. Conclusions SCT can be safely used for treatment of malignant airway tumor (MAT) in the airways. Understanding passive venting of the nitrogen gas produced as the liquid nitrogen changes to gas is important for safe use of the device. Complications can be minimized by adopting strict protocols to maximize passive venting and to allow for adequate oxygenation in between sprays. PMID:26807288

  14. Lung transplantation for bronchiolitis obliterans syndrome after allo-SCT

    DEFF Research Database (Denmark)

    Holm, A M; Riise, Gerdt; Hansson, Leif Helmuth

    2013-01-01

    and Finland were recorded and compared with survival data from the Scandiatransplant registry. In total, LTx after allo-SCT had been performed in 13 patients. Allo-SCT was done because of AML (n=6), CML (n=3), ALL (n=2), immunodeficiency (n=1) and aplastic anemia (n=1). All developed clinical c...

  15. Outcome of poor response Paediatric AML using early SCT

    DEFF Research Database (Denmark)

    Wareham, Neval E; Heilmann, Carsten; Abrahamsson, Jonas;

    2013-01-01

    treated with SCT. MATERIAL AND METHODS: Treatment was given according to the NOPHO-AML 2004 protocol. All patients received AIET (Cytarabine, Idarubicin, Etoposide, Thioguanine) and AM (Cytarabine, Mitoxantrone) as induction. We included poor response defined as > 15% blasts on day 15 after AIET (n = 17......) or > 5% blasts after AM (n = 14, refractory disease). Poor response patients received intensively timed induction and proceeded to SCT when a donor was available. RESULTS: Thirty-one of 267 evaluable patients (12%) had a poor response. SCT was performed in 25; using matched unrelated donors in 13...

  16. First SCT Barrel arrives at CERN

    CERN Multimedia

    Apsimon, R

    Mid-January saw the arrival at CERN of Barrel #3, the first of four SCT barrels. The barrels are formed as low-mass cylinders of carbon fibre skins on a honeycomb carbon core. They are manufactured in industry and then have all the final precision supports added and the final geometric metrology carried out at Geneva University. Barrel #3, complete with its 384 silicon detector modules, arrived by road from Oxford University in England where the modules were mounted using a purpose-built robot. The modules had been selected from the output of all four barrel module building clusters (in Japan, Scandinavia, USA and the UK). Since Barrel #3 will be exposed to high radiation levels within the tracker volume, these modules, representing over half a million readout channels, have been extensively tested at their operational temperature of around -25 degrees Celcius and at voltages of up to 500V. The dangers of shipping such a fragile component of ATLAS were apparent to all and considerable attention was focused...

  17. ATLAS SCT - Progress on the Silicon Modules

    CERN Multimedia

    Tyndel, M.

    The ATLAS SCT consists of 4088 silicon modules. Each module is made up of 4 silicon sensors with 1536 readout strips. Individual strips are connected to FE amplifiers, discriminators and pipelines on the module, i.e. there are 12 radiation hard ASICs, each containing 128 channels on the module. The sensors and the ASICs were developed for the ATLAS experiment and production is proceeding smoothly with over half the components delivered. The components of a module - 4 silicon sensors, a Cu/polyimide hybrid and pitch adaptor, and 12 ASICs - need to be carefully and precisely assembled onto a carbon and ceramic framework, which supports the module and removes the heat. Eleven production clusters are preparing to carry this out over the next two years. An important milestone for the barrel modules has been passed with the first cluster (KEK) now in production (~40 modules produced). A second cluster UK-B has qualified by producing five modules within specification (see below) and is about to start production. T...

  18. The Hatfield SCT lunar atlas photographic atlas for Meade, Celestron, and other SCT telescopes

    CERN Document Server

    2014-01-01

    In a major publishing event for lunar observers, the justly famous Hatfield atlas is updated in even more usable form. This version of Hatfield’s classic atlas solves the problem of mirror images, making identification of left-right reversed imaged lunar features both quick and easy. SCT and Maksutov telescopes – which of course include the best-selling models from Meade and Celestron – reverse the visual image left to right. Thus it is extremely difficult to identify lunar features at the eyepiece of one of the instruments using a conventional Moon atlas, as the human brain does not cope well when trying to compare the real thing with a map that is a mirror image of it. Now this issue has at last been solved.   In this atlas the Moon’s surface is shown at various sun angles, and inset keys show the effects of optical librations. Smaller non-mirrored reference images are also included to make it simple to compare the mirrored SCT plates and maps with those that appear in other atlases. This edition s...

  19. The ATLAS SCT Optoelectronics and the Associated Electrical Services

    CERN Document Server

    Abdesselam, A; Apsimon, R J; Band, C; Barr, A J; Batchelor, L E; Bates, R; Bell, P; Bernabeu, J; Bizzell, J; Brenner, R; Brodbeck, T; Bruckman de Renstrom, P; Buttar, C; Carter, J R; Charlton, D G; Cheplakov, A P; Chilingarov, A G; Chu, M L; Cindro, V; Demirkõz, B; Dervan, P J; Dolezal, Z; Dowell, John D; Escobar, C; Spencer, E; Ekelöf, T J C; Eckert, S; Eklund, L; Feld, L; Fraser, T J; French, M; French, R; Fuster, J; Gallop, B J; García, C; Goodrick, M J; Greenall, A; Grillo, A A; Grosse-Knetter, J; Hartjes, F; Hessey, N P; Hill, J C; Homer, R J; Hou, L S; Hughes, G; Ikegami, Y; Issever, C; Jakobs, K; Jackson, J N; Jones, M; Jones, R W L; Jones, T J; Joos, D; Jovanovic, P; Kodys, P; Kohriki, T; Kramberger, G; Lee, S C; Lester, C G; Lindsay, S W; Lozano, M; MacWaters, C P; Magrath, C A; Mahout, G; Mandic, I; Margan, E; Mathesonu, J; McMahon, T J; Meinhardt, J; Mesmer, I; Mikuž, M; Morrissey, M; Nichols, A; Nickerson, R B; O'Shea, V; Pagenis, S; Parker, M A; Parzefall, J; Pater, J; Pernegger, H; Phillips, P W; Postranecky, M; Ratoff, P N; Robson, A; Rudge, A; Runge, K; Sedlak, K; Smith, N A; Stapnes, S; Stugu, B; Tadel, M; Teng, P K; Terada, S; Tricoli, A; Turala, M; Tyndel, M; Ujiie, N; Ullán, M; Unno, Y; Viehhauser, G; Vossebeld, Joost Herman; Warren, M R M; Wastie, R L; Webel, M; Weidberg, A R; Wells, P S; White, D J; Wilson, J A

    2006-01-01

    The requirements for the optical links of the ATLAS SCT are described. From the individual detector modules to the first patch panel, the electrical services are integrated with the optical links to aid in mechanical design, construction and integration. The system architecture and critical elements of the system are described. The optical links for the ATLAS SCT have been assembled and mounted onto the carbon fibre support structures. The performance of the system as measured during QA is summarised and compared to the final performance obtained after mounting modules onto the support structures.

  20. First Combined SCT/TRT Cosmics Seen in SR1

    CERN Multimedia

    M. Jose Costa; H. Pernegger

    A major milestone for the Inner Detector project has been accomplished in early May as cosmic rays going through both the barrel Semiconductor Tracker (SCT) and Transition Radiation Tracker (TRT) have been successfully recorded in the SR1 building on the ATLAS experimental site at CERN. A cosmic-ray track in the combined SCT-TRT barrel As reported also in this issue of the eNews, in February of this year the SCT barrel was inserted into the TRT in the SR1 building. One eighth of the TRT barrel and a quarter of the SCT barrel were then cabled to power supplies and to the data acquisition system in order to verify the good operation of the detector before installation in the ATLAS cavern. After first checks of noise levels in the final detectors, a critical goal was to study its response to cosmic rays using a set of scintillators to give the external trigger, thus undertaking the enormous challenge of integrating the full chain of the detectors, the DAQ, and the reconstruction and monitoring software. A ...

  1. Performance and operation of the semiconductor tracker (SCT)

    CERN Document Server

    Dervan, P; The ATLAS collaboration

    2013-01-01

    After more than 3 years of successful operation at the LHC, we report on the operation and performance of the ATLAS Semi-Conductor Tracker (SCT) functioning in a high luminosity, high radiation environment. The SCT is constructed of 4088 silicon detector modules, for a total of 6.3 million strips. Each module is designed, constructed and tested to operate as a stand-alone unit, mechanically, electrically, optically and thermally. The modules are mounted into two types of structures: one barrel (4 cylinders) and two end-cap systems (9 disks on each end of the barrel). The SCT silicon micro-strip sensors are processed in the planar p-in-n technology. The signals are processed in the front-end ABCD3TA ASICs, which use a binary readout architecture. Data is transferred to the off-detector readout electronics via optical fibres. We find 99.3% of the SCT modules are operational and the hit efficiency exceeds the design specifications. We will report on the operation and performance of the detector, including an ove...

  2. The ATLAS SCT grounding and shielding concept and implementation

    CERN Document Server

    Bates, RL; Bernabeu, J; Bizzell, J; Bohm, J; Brenner, R; Bruckman de Renstrom, P A; Catinaccio, A; Cindro, V; Ciocio, A; Civera, J V; Chouridou, S; Dervan, P; Dick, B; Dolezal, Z; Eklund, L; Feld, L; Ferrere, D; Gadomski, S; Gonzalez, F; Gornicki, E; Greenhall, A; Grillo, A A; Grosse-Knetter, J; Gruwe, M; Haywood, S; Hessey, N P; Ikegami, Y; Jones, T J; Kaplon, J; Kodys, P; Kohriki, T; Kondo, T; Koperny, S; Lacasta, C; Lozano Bahilo, J; Malecki, P; Martinez-McKinney, F; McMahon, S J; McPherson, A; Mikulec, B; Mikus, M; Moorhead, G F; Morrissey, M C; Nagai, K; Nichols, A; O'Shea, V; Pater, J R; Peeters, S J M; Pernegger, H; Perrin, E; Phillips, P W; Pieron, J P; Roe, S; Sanchez, J; Spencer, E; Stastny, J; Tarrant, J; Terada, S; Tyndel, M; Unno, Y; Wallny, R; Weber, M; Weidberg, A R; Wells, P S; Werneke, P; Wilmut, I

    2012-01-01

    This paper describes the design and implementation of the grounding and shielding system for the ATLAS SemiConductor Tracker (SCT). The mitigation of electromagnetic interference and noise pickup through power lines is the critical design goal as they have the potential to jeopardize the electrical performance. We accomplish this by adhering to the ATLAS grounding rules, by avoiding ground loops and isolating the different subdetectors. Noise sources are identified and design rules to protect the SCT against them are described. A rigorous implementation of the design was crucial to achieve the required performance. This paper highlights the location, connection and assembly of the different components that affect the grounding and shielding system: cables, filters, cooling pipes, shielding enclosure, power supplies and others. Special care is taken with the electrical properties of materials and joints. The monitoring of the grounding system during the installation period is also discussed. Finally, after con...

  3. Optimisation of ROB mapping for SCT and Pixel detectors

    CERN Document Server

    Wheeler, S

    1999-01-01

    A simple object-oriented program has been written to simulate the SCT and Pixel detectors in order to determine the suitability of various ROB mapping schemes in the context of the Level 2 trigger. Layer and tower mappings have been investigated separately for the SCT barrel and endcap and for the Pixel barrel and endcap. Events containing one RoI were fired at each detector part and the number of ROBs hit determined. As a result, plots of ROB output data rates and ROB hit frequency as a function of ROB ID were obtained. In general it was found that layer mapping schemes might result in unacceptably high data rates and frequencies. This result would have to be confirmed with more detailed modelling. The tower mappings investigated, in general produced acceptable rates.

  4. Análisis de abundancias de estrellas δ Sct

    Science.gov (United States)

    Solano, E.; Pintado, O. I.

    Las estrellas δ Sct se encuentran en la parte inferior de la franja de inestabilidad, su tipo espectral está entre A y F y sus luminosidades se extienden entre la Secuencia Principal y 2 magnitudes por encima de ella. Sus períodos son menores que 0d.3 y sus amplitudes varían entre milésimas y décimas de magnitud. En este trabajo se realiza un análisis detallado de las abundancias de un grupo de estrellas δ Sct observadas en el CASLEO con el espectrógrafo REOSC. Este trabajo forma parte de un proyecto destinado a estudiar las relaciones existentes entre los parámetros de pulsación (período y amplitudes) y parámetros físicos tales como velocidad de rotación, temperatura efectiva, metalicidades de este tipo de estrellas.

  5. Thermal performance measurements on ATLAS-SCT KB forward modules

    CERN Document Server

    Donegà, M; D'Onofrio, M; Ferrère, D; Hirt, C; Ikegami, Y; Kohriki, T; Kondo, T; Lindsay, S; Mangin-Brinet, M; Niinikoski, T O; Pernegger, H; Perrin, E; Taylor, G; Terada, S; Unno, Y; Wallny, R; Weber, M

    2003-01-01

    The thermal design of the KB module is presented. A Finite Elements Analysis (FEA) has been used to finalize the module design. The thermal performance of an outer irradiated KB module has been measured at different cooling conditions. The thermal runaway of the module has been measured. The FEA model has been compared with the measurements and has been used to predict the thermal performance in a realistic SCT scenario.

  6. Charge deposition in the SCT due to beamloss

    CERN Document Server

    The ATLAS collaboration

    2013-01-01

    The purpose of this study was to estimate the distribution of charge collected by the strips 6 of ATLAS SCT modules in a 25ns window under two LHC proton beam scrape scenarios. 7 This was done in order to see whether this charge would be greater than the nominal amount 8 above which damage to the modules is expected to occur, which is 5nC/strip over 25ns. 9 Specifically, the damage is expected to occur to the channels of the front-end ABCD3T 10 binary readout chips of the SCT modules. Due to limited numbers of fully simulated single 11 proton collisions with the beam pipe (at 450 GeV) and the TAS collimator (at 7 TeV) a 12 method of sampling SCT hits-with-replacement is developed to obtain an upper limit on the 13 charge per strip for a 108 proton scrape over 25ns. Under this assumption the maximum 14 charge collected per strip is determined to be less than 0.4nC for the 450 GeV beam pipe 15 scrape scenario and less than 1.9nC for the 7 TeV TAS collimator scrape scenario, within 16 the damage threshold in bot...

  7. Operational experience of ATLAS SCT and Pixel Detector

    CERN Document Server

    Kocian, Martin; The ATLAS collaboration

    2017-01-01

    The ATLAS Inner Detector based on silicon sensors is consisting of a strip detector (SCT) and a pixel detector. It is the crucial component for vertexing and tracking in the ATLAS experiment. With the excellent performance of the LHC well beyond the original specification the silicon tracking detectors are facing substantial challenges in terms of data acquisition, radiation damage to the sensors, and SEUs in the readout ASICs. The approaches on how the detector systems cope with the demands of high luminosity operation while maintaining excellent performance through hardware upgrades, software and firmware algorithms, and operational settings, are presented.

  8. Amplitude Modulation in the δ Sct star KIC 7106205

    Directory of Open Access Journals (Sweden)

    Bowman Dominic. M.

    2015-01-01

    Full Text Available The δ Sct star KIC 7106205 showed amplitude modulation in a single p mode, whilst all other p and g modes remained stable in amplitude and phase over 1470 d of the Kepler dataset. The data were divided into 30 time bins of equal length and a series of consecutive Fourier transforms was calculated. A fixed frequency, calculated from a least-squares fit of all data, allowed amplitude and phase for every mode in each time bin to be tracked. The missing p mode energy was not transferred to any other visible modes.

  9. Infections by carbapenem-resistant Klebsiella pneumoniae in SCT recipients: a nationwide retrospective survey from Italy.

    Science.gov (United States)

    Girmenia, C; Rossolini, G M; Piciocchi, A; Bertaina, A; Pisapia, G; Pastore, D; Sica, S; Severino, A; Cudillo, L; Ciceri, F; Scimè, R; Lombardini, L; Viscoli, C; Rambaldi, A

    2015-02-01

    Infections by carbapenem-resistant Klebsiella pneumoniae (CRKp) represent a challenging problem after SCT. A retrospective survey (January 2010 to July 2013) involving 52 Italian centers was performed to assess the epidemiology and the prognostic factors of CRKp infections in auto- and allo-SCT. Cases of CRKp infection were reported in 53.4% of centers. CRKp infections were documented in 25 auto-SCTs and 87 allo-SCTs, with an incidence of 0.4% (from 0.1% in 2010 to 0.7% in 2013) and 2% (from 0.4% in 2010 to 2.9% in 2013), respectively. A CRKp colonization documented before or after transplant was followed by an infection in 25.8% of auto-SCT and 39.2% of allo-SCT patients. The infection-related mortality rates were 16% and 64.4%, respectively. A pre-transplant CRKp infection (hazard ratio (HR) 0.33, 95% confidence intervals (CIs) 0.15-0.74; P=0.007) and a not CRKp-targeted first-line treatment (HR 2.67, 95% CI 1.43-4.99; P=0.002) were independent factors associated with an increased mortality in allo-SCT patients who developed a CRKp infection. Our study shows challenging findings of CRKp infections in SCT patients in Italy particularly after allo-SCT. The detection of carriers and the definition of early therapeutic strategies represent critical aspects of the management of CRKp infections after SCT.

  10. Physical and emotional well-being of survivors of childhood and young adult allo-SCT

    DEFF Research Database (Denmark)

    Jensen, Josef Nathan; Gøtzsche, Frederik; Heilmann, Carsten;

    2016-01-01

    The aim of this investigation was to examine, within a population-based study of a national cohort comprising Danish survivors of allo-SCT (n = 148), the long-term effects of allo-SCT in children and young adults. Physical and emotional well-being was assessed using the Short Form 36 (SF-36......) and the HADS. Allo-SCT-related data were obtained from the participants' medical records. The study includes 148 patients, with an 89% response rate (n = 132). For comparison purposes, norm data from Danish (1994, n = 6000), Swedish (2006, n = 285), and British (2001, n = 1792) population samples were used...... of questioning (median values were within normal range). Overall scores of allo-SCT patients were similar to norm data. In conclusion, this national cohort study shows that patients treated with SCT in early life (

  11. Clinical trial of low-dose whole body irradiation "in the non-myeloablative hemtapoietic stem cell transplantation%低剂量全身照射在非清髓性干细胞移植中的临床研究

    Institute of Scientific and Technical Information of China (English)

    房彤; 高宏

    2009-01-01

    目的 观察非清髓性低剂量全身照射的临床效果和急性毒副作用.方法 2006年1月至2008年1月对27例异基因造血干细胞移植患者采用含有全身照射的非清髓预处理方案:全身照射(TBI)2 Gy,一次完成;受者原发病不同,受者机体状态、年龄、脏器功能以及供受者HAL相合情况等不同,使用的化疗方案也有不同,包括氟达拉宾、环磷酰胺、阿糖胞苷、马法兰等.预防移植物抗宿主病(GVHD)采用:环孢霉素、霉酚酸酯.结果 造血重建情况:27例均于移植后第4~8天外周血WBC降至(0.05~0.9)×109/L.中性粒细胞计数>0.5×109/L为8~22 d(中位数为10.5 d),血小板计数>30×109/L为11~28 d(中位数为14.5 d).1、2年生存率为85.2%(23/27)、77.8%(21/27).发热率65%,10例发生感染.无出血性膀胱炎和肝静脉闭塞症等并发症.急性GVHD 4例(15%),慢性GVHD 5例(19%).随访3~22个月21例(77.8%)仍存活.结论 采用低剂量全身照射的非清髓性造血干细胞移植预处理方案简便安全,并发症少,适应证广;全身照射总剂量2 Gy,1次完成的方案是安全有效的,可以达到免疫抑制效果.%Objective To observe the efficacy and acute toxicity in non-myeloablative low-dose tatal body irradiation. Methods From January 2006 to January 2008, 27 cases of hematopoietic stem cell transplantation patients received non-myeloablative pretreatment program involving low-dose whole body irradiation. Pretreatment program: the total dose of TBI was 2 Gy, once completely. According to primary disease, physical condition, age, organ function and HAL coincide situation, the patients received different chemotherapy, including FUL, CTX, Ara-C, melphalan and so on. To prevent the graft-versus-host disease (GVHD), CSA/MMF was used. Results Hematopeietic reconstruction: the peripheral blood WBC in all 27 cases reduced to (0.05-0.9) × 109/L in 4 to 8 days, with the neutrophil count > 0.5 × 109/L in 8 to 22 days (median + 10

  12. Value of liver elastography and abdominal ultrasound for detection of complications of allogeneic hemopoietic SCT.

    Science.gov (United States)

    Karlas, T; Weber, J; Nehring, C; Kronenberger, R; Tenckhoff, H; Mössner, J; Niederwieser, D; Tröltzsch, M; Lange, T; Keim, V

    2014-06-01

    Hepatic complications contribute to morbidity and mortality after allogeneic hemopoietic SCT. Liver Doppler ultrasound and elastography represent promising methods for pretransplant risk assessment and early detection of complications. Ultrasound (liver and spleen size, liver perfusion) and elastography (transient elastography (TE); right liver lobe acoustic radiation force impulse imaging (r-ARFI); left liver lobe ARFI (l-ARFI)) were prospectively evaluated in patients with indications for allo-SCT. Measurements were performed before and repeatedly after SCT. Results were compared with the incidence of life-threatening complications and death during the first 150 days after SCT. Of 59 included patients, 16 suffered from major complications and 9 of them died within the follow-up period. At baseline, liver and spleen size, liver perfusion, TE and r-ARFI did not differ significantly between patients with and without severe complications. In contrast, l-ARFI was significantly elevated in patients who later developed severe complications (1.58±0.30 m/s vs 1.37±0.27 m/s, P=0.030). After SCT, l-ARFI values remained elevated and TE showed increasing liver stiffness in patients with complications. The value of conventional liver ultrasound for prediction of severe SCT complications is limited. Increased values for TE and l-ARFI are associated with severe SCT complications and demand further evaluation.

  13. Enhanced transbuccal salmon calcitonin (sCT) delivery: effect of chemical enhancers and electrical assistance on in vitro sCT buccal permeation.

    Science.gov (United States)

    Oh, Dong-Ho; Chun, Kyeung-Hwa; Jeon, Sang-Ok; Kang, Jeong-Won; Lee, Sangkil

    2011-10-01

    This study investigates the combined effect of absorption enhancers and electrical assistance on transbuccal salmon calcitonin (sCT) delivery, using fresh swine buccal tissue. We placed 200 IU (40 μg/mL) of each sCT formulation--containing various concentrations of ethanol, N-acetyl-L-cysteine (NAC), and sodium deoxyglycocholate (SDGC)--onto the donor part of a Franz diffusion cell. Then, 0.5 mA/cm(2) of fixed anodal current was applied alone or combined with chemical enhancers. The amount of permeated sCT was analyzed using an ELISA kit, and biophysical changes of the buccal mucosa were investigated using FT-IR spectroscopy, and hematoxylin-eosin staining methods were used to evaluate histological alteration of the buccal tissues. The flux (J(s)) of sCT increased with the addition of absorption enhancer groups, but it was significantly enhanced by the application of anodal iontophoresis (ITP). FT-IR study revealed that all groups caused an increase in lipid fluidity but only the groups containing SDGC showed statistically significant difference. Although the histological data of SDGC groups showed a possibility for tissue damage, the present enhancing methods appear to be safe. In conclusion, the combination of absorption enhancers and electrical assistance is a potential strategy for the enhancement of transbuccal sCT delivery.

  14. Large pericardial effusion as a complication in adults undergoing SCT.

    Science.gov (United States)

    Norkin, M; Ratanatharathorn, V; Ayash, L; Abidi, M H; Al-Kadhimi, Z; Lum, L G; Uberti, J P

    2011-10-01

    Large pericardial effusion (LPE) leading to cardiac tamponade is a rare complication described in patients undergoing SCT. This complication is considered to be a manifestation of chronic GVHD; however its pathophysiology is poorly understood. Currently, there are no published data systematically describing the incidence, clinical characteristics and outcomes of LPEs in adult stem cell transplant recipients. We retrospectively evaluated 858 adult patients (512 autologous, 148 related and 198 unrelated donor) who underwent hematopoietic stem cell and BM transplants at our institution from 2005 to 2008 for the development of post transplant LPE. Seven patients (0.8%) were found to have LPEs and all these patients had undergone unrelated allografts. The median day of diagnosis post transplant was 229 (range 42-525). None of these patients had active manifestations of GVHD other than serositis at the time of LPE detection. Pericardial window (PW) was successfully placed in all patients who developed cardiac tamponade and most patients with LPE were effectively treated by increasing immunosuppression. We conclude that LPE is a rare late complication after allogeneic transplant in adults and in our study developed only after unrelated transplant. PW can be safely performed in these patients and LPEs can be successfully treated with intensification of systemic immunosupression.

  15. Antiviral Drug- and Multidrug Resistance in Cytomegalovirus Infected SCT Patients

    Directory of Open Access Journals (Sweden)

    Katharina Göhring

    2015-01-01

    Full Text Available In pediatric and adult patients after stem cell transplantation (SCT disseminated infections caused by human cytomegalovirus (HCMV can cause life threatening diseases. For treatment, the three antivirals ganciclovir (GCV, foscarnet (PFA and cidofovir (CDV are approved and most frequently used. Resistance to all of these antiviral drugs may induce a severe problem in this patient cohort. Responsible for resistance phenomena are mutations in the HCMV phosphotransferase-gene (UL97 and the polymerase-gene (UL54. Most frequently mutations in the UL97-gene are associated with resistance to GCV. Resistance against all three drugs is associated to mutations in the UL54-gene. Monitoring of drug resistance by genotyping is mostly done by PCR-based Sanger sequencing. For phenotyping with cell culture the isolation of HCMV is a prerequisite. The development of multidrug resistance with mutation in both genes is rare, but it is often associated with a fatal outcome. The manifestation of multidrug resistance is mostly associated with combined UL97/UL54-mutations. Normally, mutations in the UL97 gene occur initially followed by UL54 mutation after therapy switch. The appearance of UL54-mutation alone without any detection of UL97-mutation is rare. Interestingly, in a number of patients the UL97 mutation could be detected in specific compartments exclusively and not in blood.

  16. Hot off the press - First Combined SCT/TRT Endcap Cosmics Seen in SR1

    CERN Multimedia

    Christian Schmitt

    Following the successful combined SCT/TRT barrel test in the Spring 2006 (see ATLAS eNews from May 2006), a similar combined SCT/TRT endcap test is currently being performed in the SR1 building on the ATLAS experimental site at CERN. One quadrant of the SCT and two sectors of the TRT have been cabled up and are used in this test. The picture shows one of the first combined tracks seen in the cosmics runs. The data taking and combined testing is expected to last until December 11th. The event display below shows one of the first combined tracks seen in the cosmics run. There are three different views of the same event: the top left part shows a x-y view of the event where the track can be seen in red, the SCT spacepoints in green, and the SCT strips in grey. On the right is the z-phi view, where also the TRT DriftCircles can be seen as white dots. In the bottom window, the TRT wheels are on top and the SCT disks are shown below with the hits corresponding to those shown in the top window. The TRT DriftCircl...

  17. Matched-pair analysis to compare the outcomes of a second salvage auto-SCT to systemic chemotherapy alone in patients with multiple myeloma who relapsed after front-line auto-SCT.

    Science.gov (United States)

    Yhim, H-Y; Kim, K; Kim, J S; Kang, H J; Kim, J-A; Min, C-K; Bae, S H; Park, E; Yang, D-H; Suh, C; Kim, M K; Mun, Y-C; Eom, H S; Shin, H J; Yoon, H-J; Kwon, J H; Lee, J H; Kim, Y S; Yoon, S-S; Kwak, J-Y

    2013-03-01

    The aims of this study were to investigate the outcomes of second salvage auto-SCT and to identify the impacts of a second auto-SCT compared with systemic chemotherapy alone on disease outcome. Data from 48 patients who underwent second auto-SCT were matched to 144 patients (1:3) who received systemic chemotherapy alone from the Korean Myeloma Registry. Groups were matched for nine potential prognostic factors and compared for treatment outcomes. The median age of matching-pairs at relapse was 55.5 years. A total of 156 patients (81%) received vincristine, doxorubicin and dexamethasone induction therapy before the first auto-SCT. Thirty-five patients (73%) in the second auto-SCT group received novel agent-based therapies before the second auto-SCT, and similar proportion in both groups received novel therapies after relapse of front-line auto-SCT. With a median follow-up of 55.3 months, patients who underwent a second auto-SCT had significantly better median OS (55.5 vs 25.4 months, P=0.035). In multivariate analysis for OS, auto-SCT, International Staging System III and salvage chemotherapy alone were independent predictors for worse OS. The outcomes of second auto-SCT appear to be superior to those of systemic chemotherapy alone. A randomized trial comparing both treatment strategies is required.

  18. Results of a search for γ Dor and δ SCT stars with the Kepler spacecraft

    Energy Technology Data Exchange (ETDEWEB)

    Bradley, P. A.; Miles, L. F. [XCP-6, MS F-699 Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Guzik, J. A. [XTD-NTA, MS T-086 Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Uytterhoeven, K. [Instituto de Astrofisica de Canarias, 38200 La Laguna, Tenerife, Spain and Departamento de Astrofisica, Universidad de La Laguna, E-38200 La Laguna, Tenerife (Spain); Jackiewicz, J. [New Mexico State University, Las Cruces, NM 88003 (United States); Kinemuchi, K., E-mail: pbradley@lanl.gov [Apache Point Observatory, Sunspot, NM 88349 (United States)

    2015-02-01

    The light curves of 2768 stars with effective temperatures and surface gravities placing them near the gamma Doradus (γ Dor)/delta Scuti (δ Sct) instability region were observed as part of the Kepler Guest Observer program from Cycles 1 through 5. The light curves were analyzed in a uniform manner to search for γ Dor, δ Sct, and hybrid star pulsations. The γ Dor, δ Sct, and hybrid star pulsations extend asteroseismology to stars slightly more massive (1.4–2.5 M{sub ⊙}) than our Sun. We find 207 γ Dor, 84 δ Sct, and 32 hybrid candidate stars. Many of these stars are cooler than the red edge of the γ Dor instability strip as determined from ground-based observations made before Kepler. A few of our γ Dor candidate stars lie on the hot side of the ground-based γ Dor instability strip. The hybrid candidate stars cover the entire region between 6200 K and the blue edge of the ground-based δ Sct instability strip. None of our candidate stars are hotter than the hot edge of the ground-based δ Sct instability strip. Our discoveries, coupled with the work of others, show that Kepler has discovered over 2000 γ Dor, δ Sct, and hybrid star candidates in the 116 square degree Kepler field of view. We found relatively few variable stars fainter than magnitude 15, which may be because they are far enough away to lie between spiral arms in our Galaxy, where there would be fewer stars.

  19. Amplitude modulation in δ Sct stars: statistics from an ensemble study of Kepler targets

    Science.gov (United States)

    Bowman, Dominic M.; Kurtz, Donald W.; Breger, Michel; Murphy, Simon J.; Holdsworth, Daniel L.

    2016-08-01

    We present the results of a search for amplitude modulation of pulsation modes in 983 δ Sct stars, which have effective temperatures between 6400 ≤ Teff ≤ 10 000 K in the Kepler Input Catalogue and were continuously observed by the Kepler Space Telescope for 4 yr. We demonstrate the diversity in pulsational behaviour observed, in particular non-linearity, which is predicted for δ Sct stars. We analyse and discuss examples of δ Sct stars with constant amplitudes and phases; those that exhibit amplitude modulation caused by beating of close-frequency pulsation modes; those that exhibit pure amplitude modulation (with no associated phase variation); those that exhibit phase modulation caused by binarity; and those that exhibit amplitude modulation caused by non-linearity. Using models and examples of individual stars, we demonstrate that observations of the changes in amplitude and phase of pulsation modes can be used to distinguish among the different scenarios. We find that 603 δ Sct stars (61.3 per cent) exhibit at least one pulsation mode that varies significantly in amplitude over 4 yr. Conversely, many δ Sct stars have constant pulsation amplitudes so short-length observations can be used to determine precise frequencies, amplitudes and phases for the most coherent and periodic δ Sct stars. It is shown that amplitude modulation is not restricted to a small region on the HR diagram, therefore not necessarily dependent on stellar parameters such as Teff or log g. Our catalogue of 983 δ Sct stars will be useful for comparisons to similar stars observed by K2 and TESS, because the length of the 4-yr Kepler data set will not be surpassed for some time.

  20. Construction and Performance of the ATLAS SCT Barrels and Cosmic Tests

    CERN Document Server

    Demirkoz, Bilge Melahat

    2007-01-01

    ATLAS is a multi-purpose detector for the LHC and will detect proton-proton collisions with center of mass energy of $14$TeV. Part of the central inner detector, the Semi-Conductor Tracker (SCT) barrels, were assembled and tested at Oxford University and later integrated at CERN with the TRT (Transition Radiation Tracker) barrel. The barrel SCT is composed of 4 layers of silicon strip modules with two sensor layers with $80 \\mu$m channel width. The design of the modules and the barrels has been optimized for low radiation length while maintaining mechanical stability, bringing services to the detector, and ensuring a cold and dry environment. The high granularity, high detector efficiency and low noise occupancy ($ < 5 \\times 10^{-4}$) of the SCT will enable ATLAS to have an efficient pattern recognition capability. Due to the binary nature of the SCT read-out, a stable read-out system and the calibration system is of critical importance. SctRodDaq is the online software framework for the calibration and a...

  1. Amplitude modulation in $\\delta$ Sct stars: statistics from an ensemble study of Kepler targets

    CERN Document Server

    Bowman, Dominic M; Breger, Michel; Murphy, Simon J; Holdsworth, Daniel L

    2016-01-01

    We present the results of a search for amplitude modulation of pulsation mode frequencies in 983 $\\delta$ Sct stars, which have effective temperatures between 6400 $\\leq T_{\\rm eff} \\leq$ 10 000 K in the Kepler Input Catalogue and were continuously observed by the Kepler Space Telescope for 4 yr. We demonstrate the diversity in pulsational behaviour observed, in particular nonlinearity, which is predicted for $\\delta$ Sct stars. We analyse and discuss examples of $\\delta$ Sct stars with constant amplitudes and phases; those that exhibit amplitude modulation caused by beating of close-frequency pulsation modes; those that exhibit pure amplitude modulation (with no associated phase variation); those that exhibit phase modulation caused by binarity; and those that exhibit amplitude modulation caused by nonlinearity. Using models and examples of individual stars, we demonstrate that observations of the changes in amplitude and phase of pulsation modes can be used to distinguish among the different scenarios. We f...

  2. VizieR Online Data Catalog: Kepler δ Sct stars amplitude modulation (Bowman+, 2016)

    Science.gov (United States)

    Bowman, D. M.; Kurtz, D. W.; Breger, M.; Murphy, S. J.; Holdsworth, D. L.

    2016-06-01

    We searched for amplitude modulation of pulsation modes in δ Sct stars observed by the Kepler Space Telescope. The number of pulsation modes out of a maximum of twelve that have constant amplitudes and variable amplitudes are given in the columns NoMod and AMod, respectively, along with stellar parameters from Huber et al. (2014, Cat. J/ApJS/211/2). Table 1 is the full version for all 983 δ Sct stars the abridged version of the paper. (1 data file).

  3. BK virus-hemorrhagic cystitis following allogeneic stem cell transplantation: Clinical characteristics and utility of leflunomide treatment.

    Science.gov (United States)

    Park, Young Hoon; Lim, Joo Han; Yi, Hyeon Gyu; Lee, Moon Hee; Kim, Chul Soo

    2016-04-18

    BK virus-hemorrhagic cystitis (BKV-HC) is a potential cause of morbidity and mortality in patients having undergone allogeneic stem cell transplantation (Allo-SCT). We analyzed the clinical features of BKV-HC following Allo-SCT and reported the utility of leflunomide therapy for BKV-HC.

  4. Auto-SCT improves survival in systemic light chain amyloidosis: a retrospective analysis with 14-year follow-up.

    Science.gov (United States)

    Parmar, S; Kongtim, P; Champlin, R; Dinh, Y; Elgharably, Y; Wang, M; Bashir, Q; Shah, J J; Shah, N; Popat, U; Giralt, S A; Orlowski, R Z; Qazilbash, M H

    2014-08-01

    Optimal treatment approach continues to remain a challenge for systemic light chain amyloidosis (AL). So far, Auto-SCT is the only modality associated with long-term survival. However, failure to show survival benefit in randomized study raises questions regarding its efficacy. We present a comparative outcome analysis of Auto-SCT to conventional therapies (CTR) in AL patients treated over a 14-year period at our institution. Out of the 145 AL amyloidosis patients, Auto-SCT was performed in 80 patients with 1-year non-relapse mortality rate of 12.5%. Novel agents were used as part of induction therapy in 56% of transplant recipients vs 46% of CTR patients. Hematological and organ responses were seen in 74.6% and 39% in the Auto-SCT arm vs 53% and 12% in the CTR arm, respectively. The projected 5-year survival for Auto-SCT vs CTR was 63% vs 38%, respectively. Landmark analysis of patients alive at 1-year after diagnosis showed improved 5-year OS of 72% with Auto-SCT vs 65% in the CTR arm. In the multivariate analysis, age Auto-SCT were associated with improved survival. In conclusion, Auto-SCT is associated with long-term survival for patients with AL amyloidosis.

  5. The excitation of solar-like oscillations in a δ Sct star by efficient envelope convection

    DEFF Research Database (Denmark)

    Antoci, V.; Handler, G.; Kallinger, T.

    2011-01-01

    Delta Scuti (δSct) stars are opacity-driven pulsators with masses of 1.5-2.5Msolar, their pulsations resulting from the varying ionization of helium. In less massive stars such as the Sun, convection transports mass and energy through the outer 30per cent of the star and excites a rich spectrum o...

  6. Distress, problems and supportive care needs of patients treated with auto- or allo-SCT

    NARCIS (Netherlands)

    J. Dekker; O. Visser; Annemarie Braamse; P.C. Huijgens; prof Berno van Meijel; P. van Oppen; M.M. Gerrits; P. Cuijpers; A.T. Beekman; A.D. Boenink

    2012-01-01

    Identifying factors that predict health-related quality of life (QOL) following hematopoietic SCT, is important in estimating patients’ abilities to adjust to the consequences of their disease and treatment. As the studies that have been published on this subject are scattered, the present study

  7. Aerobic exercise capacity at long-term follow-up after paediatric allogeneic haematopoietic SCT

    DEFF Research Database (Denmark)

    Mathiesen, S; Uhlving, H H; Buchvald, F

    2014-01-01

    Peak oxygen uptake (VO2peak), a measure of aerobic exercise capacity, predicts mortality and morbidity in healthy and diseased individuals. Our aim was to determine VO2peak years after paediatric allogeneic haematopoietic SCT (HSCT) and to identify associations with baseline patient and donor cha...

  8. A snap-shot of a cosmic ray event seen in the different layers of both the SCT and TRT detectors.

    CERN Multimedia

    2006-01-01

    Clean tracks of cosmic rays were detected in the completed semiconductor tracker (SCT) and transition radiation tracker (TRT) barrels. These tracking tests come just months after the successful insertion of the SCT into the TRT

  9. Long-term outcome of patients with multiple [corrected] myeloma-related advanced renal failure following auto-SCT.

    Science.gov (United States)

    Glavey, S V; Gertz, M A; Dispenzieri, A; Kumar, S; Buadi, F; Lacy, M; Hayman, S R; Kapoor, P; Dingli, D; McCurdy, A; Hogan, W J; Gastineau, D A; Leung, N

    2013-11-01

    Renal failure commonly complicates multiple myeloma (MM) and is associated with reduced survival. It is not clear whether auto-SCT results in improved renal function or attainment of independence from dialysis in patients with advanced renal impairment due to MM. We conducted a retrospective cohort study of all patients who underwent auto-SCT for MM complicated by advanced renal failure at our institution over a 10-year period (2000-2010). We aimed to assess the association between auto-SCT and renal outcome in patients with serum creatinine (SCr) over 3 mg/dL, attributable to MM, including those who were dialysis dependent. Thirty patients (2.8% of all auto-SCT patients) met inclusion criteria. Fourteen of 15 patients who were dialysis dependent before auto-SCT remained dialysis dependent in the long term despite hematological response (HR). Of the remaining 15 patients with SCr >3 mg/dL, an improvement in glomerular filtration rate (GFR) from 15 to 19.4 mL/min/1.73 m(2) was noted post auto-SCT (P=0.035); however, neither HR post auto-SCT or pre-existing renal function were independently associated with renal outcome. Auto-SCT was not associated with independence from dialysis in patients with renal failure due to MM at our institution. Although auto-SCT was associated with an improvement in GFR in patients with SCr >3 mg/dL, this improvement was not related to HR.

  10. Particle Physics and Astronomy Research Council (PPARC) members, United Kingdom, visiting the ATLAS semiconductor tracker (SCT) module tests.

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    Photo 01: Mr Peter Warry, PPARC Chairman, Victrex Plc, United Kingdom visiting the ATLAS SCT module tests with Dr Joleen Pater, SCT (Manchester). Photo 02: PPARC Council Members, United Kingdom, visiting the ATLAS SCT module tests. L.t to r.: Mrs Judith Scott, Chief Executive, British Computer Society, Prof. George Efstathiou, Institute of Astronomy, University of Cambridge, Mr Peter Warry, PPARC Chairman, Victrex Plc, Prof. Martin Ward, Director X-Ray Astronomy, of Leicester, Prof. James Stirling, Director, Institute for Particle Physics Phenomenology, University of Durham and Prof. Brian Foster, University of Bristol.

  11. Performance And Radiation Hardness Of The Atlas/sct Detector Module

    CERN Document Server

    Eklund, L

    2003-01-01

    The ATLAS experiment is a general purpose experiment being constructed at the Large Hadron Collider (LHC) at FERN, Geneva. ATLAS is designed to exploit the full physics potential of LHC, in particular to study topics concerning the Higgs mechanism, Super-symmetry and CP violation. The cross sections for the processes under study are extremely small, requiring very high luminosity colliding beams. The Semiconductor Tracker (SCT) is an essential part of the Inner Detector tracking system of ATLAS. The active elements of the SCT is 4088 detector modules, tiled on four barrel cylinders and eighteen endcap disks. As a consequence of the high luminosity, the detector modules will operate in a harsh radiation environment. This thesis describes work concerning radiation hardness, beam test performance and methods for production testing of detector modules. The radiation hardness studies have been focused on the electrical performance of the front-end ASIC and the detector module. The results have identified features ...

  12. HD 41641: a classical $\\delta$ Sct-type pulsator with chemical signatures of an Ap star

    CERN Document Server

    Escorza, A; Tkachenko, A; Van Reeth, T; Ryabchikova, T; Neiner, C; Poretti, E; Rainer, M; Michel, E; Baglin, A; Aerts, C

    2016-01-01

    Among the known groups of pulsating stars, $\\delta$ Sct stars are one of the least understood. The theoretical models do not predict the oscillation frequencies that observations reveal. Complete asteroseismic studies are necessary to improve these models and better understand the internal structure of these targets. In this paper, we study the $\\delta$ Sct star HD 41641 with the ultimate goal of understanding its oscillation pattern. The target has been simultaneously observed by the CoRoT space telescope and the HARPS high-resolution spectrograph. The photometric data set was analyzed with the software package PERIOD04, while FAMIAS was used to analyze the line profile variations. The method of spectrum synthesis was used for spectroscopically determining the fundamental atmospheric parameters and the individual chemical abundances. A total of 90 different frequencies was identified and analyzed. An unambiguous identification of the azimuthal order of the surface geometry could be provided for the dominant ...

  13. Bronchiolitis obliterans after allo-SCT: clinical criteria and treatment options

    DEFF Research Database (Denmark)

    Uhlving, H H; Buchvald, F; Heilmann, C J

    2012-01-01

    Bronchiolitis obliterans (BO) following allogeneic haematopoietic SCT (HSCT) is a serious complication affecting 1.7-26% of the patients, with a reported mortality rate of 21-100%. It is considered a manifestation of chronic graft-versus-host disease, but our knowledge of aetiology and pathogenes...... treatment options for BO and presents the treatment results with HDPM in a paediatric national HSCT-cohort.Bone Marrow Transplantation advance online publication, 29 August 2011; doi:10.1038/bmt.2011.161....

  14. Cooling Performance Test of the SCT LV&HV Power Supply Rack

    CERN Document Server

    Böhm, J; Vacek, V

    2005-01-01

    The cooling performance test of the 52U rack, housing SCT LV&HV power supplies for 192 detector modules, being located in USA15 cavern, has been curried out. The rack was equipped with two air-water heat exchangers, air turbine, four vertical fan tray units under crates and horizontal fans in four Artesyn AC/DC power supply units. The resistive dummy loads for 192 power supply channels have been placed in four crates and housed in the adjacent rack.

  15. Solid and Cystic Tumor (SCT of the Pancreas in an Adult Man

    Directory of Open Access Journals (Sweden)

    K. Ohiwa

    1997-01-01

    Full Text Available Solid and cystic tumor (SCT of the pancreas predominantly Occurs in women, and the occurrence in men is extremely rare. We experienced a male case of SCT. A 38-year-old man was admitted with the complaint of upper abdominal pain. CT scan showed the presence of a mass in the head of the pancreas. The mass was composed of high density areas and low density areas. Ultrasonograms revealed the mass being composed of high echoic areas and low echoic areas. The mass .was hypovascular on angiography. SCT was suspected and pancreaticoduodenectomy was performed. The cut surface of the tumor showed mainly cystic degenerative areas containing dark red hemorrhagic materials. Microscopically, there were solid areas in the periphery and pseudopapillary areas in the center. No metastasis was found in the removed lymph nodes. The tumor cells were not stained by Grimelius' silver stain. The tumor cells were positive for alpha-l-antitrypsin (AAT and neuron-specific enolase (NSE. Pancreatic hormones such as insulin, glucagon, and somatostatin were all negative. Electron micrograph showed that tumor cells were rich in mitochondria. Zymogen granules and neurosecretory granules were not detected. Estrogen receptor (ER and progesterone receptor (PR were both negative.

  16. Balancing efficacy with cost: antiemetic control in the pediatric stem cell transplant (SCT) population.

    Science.gov (United States)

    Parsons, S K; Hoorntje, L E; Levine, K J; Mayer, D K; Eichelberger, W J; Guinan, E C

    2000-03-01

    We studied the practice patterns regarding intravenous (i.v.) ondansetron in children receiving stem cell transplants (SCT) at The Children's Hospital, Boston to identify cost efficiencies. The pharmacy provided information on material and preparation costs on 36 patients who received i.v. ondansetron during 41 SCT in 1995. We examined the effects of frequency, duration, and route of administration on costs. There were 498 days of ondansetron administration costing $49,083 (95$). Tremendous variation existed in frequency and duration with one third receiving i.v. ondansetron once daily, despite published evidence of equivalence of once a day and divided dosing. A switch to once daily i.v. dosing for all patients would have resulted in >/=28% savings. The median duration of use was 11 days (range 1-48); placing a cap for 7-10 days based on the length of SCT conditioning regimens, would produce savings of 48-60% over current use. By shifting administration route from i.v. to oral, a savings of 67% over current use, without a cap on duration, would be realized. Identifying areas for cost savings can be achieved after thorough analysis of all the component costs. We demonstrated that significant cost reductions could be realized by simple changes in prescribing practices without jeopardizing efficacy. These savings are achieved by standardizing dosing interval, route of administration and duration of treatment without altering daily dosage or access to an effective antiemetic. Bone Marrow Transplantation (2000) 25, 553-557.

  17. Long-term renal toxicity in children following fractionated total-body irradiation (TBI) before allogeneic stem cell transplantation (SCT)

    Energy Technology Data Exchange (ETDEWEB)

    Gerstein, Johanna; Meyer, Andreas; Fruehauf, Joerg; Karstens, Johann H.; Bremer, Michael [Dept. of Radiation Oncology, Medical School Hannover (Germany); Sykora, Karl-Walter [Dept. of Pediatric Hematology and Oncology, Medical School Hannover (Germany)

    2009-11-15

    Purpose: to retrospectively assess the incidence and time course of renal dysfunction in children ({<=} 16 years) following total-body irradiation (TBI) before allogeneic stem cell transplantation (SCT). Patients and methods: between 1986 and 2003, 92 children (median age, 11 years; range, 3-16 years) underwent TBI before allogeneic SCT. 43 of them had a minimum follow-up of 12 months (median, 51 months; range, 12-186 months) and were included into this analysis. Conditioning regimen included chemotherapy and fractionated TBI with 12 Gy (n = 26) or 11.1 Gy (n = 17). In one patient, renal dose was limited to 10 Gy by customized renal shielding due to known nephropathy prior to SCt. Renal dysfunction was defined as an increase of serum creatinine > 1.25 times the upper limit of age-dependent normal. Results: twelve children (28%) experienced an episode of renal dysfunction after a median of 2 months (range, 1-10 months) following SCT. In all but one patient renal dysfunction was transient and resolved after a median of 8 months (range, 3-16 months). One single patient developed persistent renal dysfunction with onset at 10 months after SCT. None of these patients required dialysis. The actuarial 3-year freedom from persistent renal toxicity for children surviving > 12 months after SCt was 97.3%. Conclusion: the incidence of persistent renal dysfunction after fractionated TBI with total doses {<=} 12 Gy was very low in this analysis. (orig.)

  18. Sporadic late-onset nemaline myopathy with MGUS: long-term follow-up after melphalan and SCT.

    Science.gov (United States)

    Voermans, Nicol C; Benveniste, Olivier; Minnema, Monique C; Lokhorst, Henk; Lammens, Martin; Meersseman, Wouter; Delforge, Michel; Kuntzer, Thierry; Novy, Jan; Pabst, Thomas; Bouhour, Françoise; Romero, Norma; Leblond, Veronique; Bergh, Peter van den; Vekemans, Marie-Christiane; van Engelen, Baziel G; Eymard, Bruno

    2014-12-02

    Sporadic late-onset nemaline myopathy (SLONM) is a rare, late-onset myopathy that progresses subacutely. If associated with a monoclonal gammopathy of unknown significance (MGUS), the outcome is unfavorable: the majority of these patients die within 1 to 5 years of respiratory failure. This study aims to qualitatively assess the long-term treatment effect of high-dose melphalan (HDM) followed by autologous stem cell transplantation (SCT) in a series of 8 patients with SLONM-MGUS. We performed a retrospective case series study (n = 8) on the long-term (1-8 years) treatment effect of HDM followed by autologous SCT (HDM-SCT) on survival, muscle strength, and functional capacities. Seven patients showed a lasting moderate-good clinical response, 2 of them after the second HDM-SCT. All of them had a complete, a very good partial, or a partial hematologic response. One patient showed no clinical or hematologic response and died. This case series shows the positive effect of HDM-SCT in this rare disorder. Factors that may portend an unfavorable outcome are a long disease course before the hematologic treatment and a poor hematologic response. Age at onset, level and type of M protein (κ vs λ), and severity of muscle weakness were not associated with a specific outcome. This study provides Class IV evidence that for patients with SLONM-MGUS, HDM-SCT increases the probability of survival and functional improvement. © 2014 American Academy of Neurology.

  19. Discovery of binarity, spectroscopic frequency analysis, and mode identification of the delta Sct star 4CVn

    CERN Document Server

    Schmid, V S; Breger, M; Degroote, P; Aerts, C; Beck, P G; Tkachenko, A; Van Reeth, T; Bloemen, S; Debosscher, J; Castanheira, B G; McArthur, B E; Pápics, P I; Fritz, V; Falcon, R E

    2014-01-01

    More than 40 years of ground-based photometric observations of the delta Sct star 4CVn revealed 18 independent oscillation frequencies, including radial as well as non-radial p-modes of low spherical degree l= 33%. This relatively high rotation rate hampers unique mode identification, since higher-order effects of rotation are not included in the current methodology. We conclude that, in order to achieve unambiguous mode identification for 4CVn, a complete description of rotation and the use of blended lines have to be included in mode-identification techniques.

  20. Small-Sized Clone of T Cells in Multiple Myeloma Patient after Auto-SCT: T-LGL Leukemia Type or Clonal T-Cell Aberration?

    OpenAIRE

    Giuseppe Mele; Marilena Greco; Maria Rosaria Coppi; Giacomo Loseto; Angela Melpignano; Salvatore Mauro; Gianni Quarta

    2013-01-01

    Second cancers and particularly postransplant lymphoproliferative disorders (PTLDs) are extremely rare in patients undergoing autologous peripheral blood stem cell transplantation (auto-SCT). We report the case of clonally rearranged T-cell expansion which occurred after auto-SCT for Multiple Myeloma (MM). Does asymptomatic clonal T-cell large granular lymphocytic proliferation, in our experience, represent either a secondary cancer after auto-SCT or clonal T cell aberration or derive from ex...

  1. Early clinical indicators of transplant-associated thrombotic microangiopathy in pediatric neuroblastoma patients undergoing auto-SCT.

    Science.gov (United States)

    Laskin, B L; Goebel, J; Davies, S M; Khoury, J C; Bleesing, J J; Mehta, P A; Filipovich, A H; Paff, Z N; Lawrence, J M; Yin, H J; Pinkard, S L; Jodele, S

    2011-05-01

    Patients undergoing auto-SCT for neuroblastoma present a unique population to study transplant-associated thrombotic microangiopathy (TA-TMA), due to standardized chemotherapy and later exposure to radiation and cis-retinoic acid (cis-RA). We retrospectively analyzed 20 patients after auto-SCT to evaluate early clinical indicators of TA-TMA. A total of 6 patients developing TA-TMA (30% prevalence) were compared with 14 controls. Four of six patients were diagnosed with TA-TMA by 25 days after auto-SCT. Compared with controls, TA-TMA patients had higher average systolic and diastolic blood pressure levels during high-dose chemotherapy and developed hypertension by day 13 after auto-SCT. Proteinuria was a significant marker for TA-TMA, whereas blood and platelet transfusion requirements were not. Serum creatinine did not differ between groups post transplant. However, patients with TA-TMA had a 60% decrease in renal function from baseline by nuclear glomerular filtration rate, compared with a 25% decrease in those without TA-TMA (P=0.001). There was no TA-TMA-related mortality. Significant complications included end-stage renal disease (n=1) and polyserositis (n=3). Patients with TA-TMA were unable to complete cis-RA therapy after auto-SCT. We suggest that careful attention to blood pressure and urinalysis will assist in the early diagnosis of TA-TMA, whereas serum creatinine seems to be an insensitive marker for this condition.

  2. The role of HLA antibodies in allogeneic SCT: is the 'type-and-screen' strategy necessary not only for blood type but also for HLA?

    Science.gov (United States)

    Yoshihara, S; Taniguchi, K; Ogawa, H; Saji, H

    2012-12-01

    The role of HLA antibodies in SCT has drawn increasing attention because of the significantly increased number of patients who receive HLA-mismatched SCT, including cord blood transplantation, haploidentical SCT and unrelated SCT. Technical advancements in the methods of HLA Ab testing have realized rapid, accurate and objective identification, as well as quantification of specific HLA antibodies. Recent clinical studies have suggested that the presence of donor-specific HLA antibodies (DSA) in patients is associated with graft failure in HLA-mismatched SCT when the above-listed stem cell sources are used and results in different impacts. Of note, most of the 'HLA-matched' unrelated SCT actually involve HLA mismatches in HLA-DP and the presence of antibodies against this locus has been reported to be associated with graft failure. Thus, HLA Ab should be examined as a work-up for all patients who undergo SCT from 'alternative donors.' The simplest route for preventing HLA Ab-mediated graft failure in Ab-positive patients is to avoid donors who possess the target Ag of HLA antibodies. If SCT from such donors must be performed, treatment for DSA before SCT may improve the chances of successful donor engraftment.

  3. Comparison of the effects of salmon calcitonin (sCT) and calcitonin gene-related peptide (CGRP) in a number of in vivo and in vitro tests

    Energy Technology Data Exchange (ETDEWEB)

    Welch, S.P.; Brase, D.; Cooper, C.; Dewey, W.L.

    1986-03-05

    sCT and CGRP have been shown previously to have multiple activities in the central nervous system (CNS). Recent work has shown that CGRP (15 ..mu..g) intraventricularly (IVT) produces a naloxone reversible 37% inhibition in the p-phenylquinone test (PPQ) accompanied by severe diarrhea. The ED50 of sCT in the PPQ test is 362 ng and this effect is not reversed totally by naloxone. The onset of CGRP is more rapid than that of sCT. sCT and CGRP (10/sup -6/M) both produce naloxone reversible inhibition of the electrically stimulated guinea pig ileum (GPI) (25% and 50% respectively). Both sCT and CGRP (10/sup -6/ M) produce contracture (15% and 40% respectively) of the non-stimulated GPI that is not blocked by atropine. Both sCT and CGRP block the naloxone-induced contracture of the morphine (MS04) dependent ilea (29% and 68% respectively). Both sCT and CGRP produce biphasic shifts in the MS04 acetylcholine dose-effect curves in the stimulated and nonstimulated GPI, respectively. Neither sCT nor CGRP (10/sup -9/ to 10/sup -4/ M) displaces /sup 3/H-naloxone binding to mouse brain membranes. Both sCT and CGRP may produce their effects by modulation of CA/sup +2/ fluxes in the CNS and GPI.

  4. 基于SCT3918的CDMR数字对讲机设计%Based on the SCT3918 CDMR digital radio design

    Institute of Scientific and Technical Information of China (English)

    闫复利

    2013-01-01

    为了响应国家工业和信心产业部[2009]666号文件我国数字对讲机实现模拟转数字化的要求,并且为了方便企业生产和调试、降低成本的目的.采用国产基带芯片SCT3918设计了一款适应我国国情的数字对讲机CDMR(China Digital Mobile Radio),在实验室内做了射频技术指标测试、音频技术指标测试、可靠性测试,实验结果表明射频技术指标符合[2009]666号文件要求,音频技术指标符合《移动通信调频无线电话机通用技术条件》,设计符合我国对讲机模拟转数字的政策、适合我国的国情、便于企业生产和调试.%In response to national industry and the ministry of industry and confidence [2009] 666 date file in the digital intercom simulating turn digital requirements,and in order to facilitate the enterprise production and debugging,lower the cost of purpose.The domestic baseband chip design of a SCT3918 to adapt to the situation of our country's digital intercom CDMR,in the laboratory to do the rf technology index test,audio technology index test,reliability test,the experimental results show that radio frequency technology index comply with [2009] no.666 document requirements,audio technology indicators meet the mobile communication FM radio telephone general technical conditions ",design conforms to our country intercom simulation turn digital policies,suitable for China's national conditions,is advantageous for the enterprise production and debugging.

  5. Escalating doses of donor lymphocytes for incipient graft rejection following SCT for thalassemia.

    Science.gov (United States)

    Frugnoli, I; Cappelli, B; Chiesa, R; Biral, E; Noè, A; Evangelio, C; Fossati, M; Napolitano, S; Ciceri, F; Roncarolo, M G; Marktel, S

    2010-06-01

    Mixed chimerism (MC) and secondary graft failure are frequent events following SCT for thalassemia. There is limited information regarding the outcome of donor lymphocyte infusion (DLI) to prevent rejection, mainly from case reports describing only successful cases. We describe a series of seven children affected by beta-thalassemia treated with escalating doses of DLI for level 2-3 MC (donor<90%) following myeloablative SCT from a matched family donor. The infusions were safe and no acute or chronic GVHD were documented; five patients experienced neutropenia and thrombocytopenia resolving spontaneously. DLI was successful in converting to full donor chimerism two patients stratified in the low-risk class (Pesaro class II). Conversely, for five high-risk patients, DLI was not effective in preventing secondary graft failure. This limited series suggests that escalating doses of DLI are safe in thalassemia patients post myeloablative therapy but efficacy may be jeopardized by rapidly growing anti-donor alloimmunity in high-risk patients. We suggest giving escalating doses of donor T cells to attempt a graft-versus-thalassemia as soon as level 2-3 MC is detected.

  6. Prevalence of Three-Rooted Mandibular First Molars among Indians Using SCT

    Directory of Open Access Journals (Sweden)

    Amit Kumar Garg

    2013-01-01

    Full Text Available Undetected extra roots or root canals are a major reason for failure of endodontic treatment. Failure to recognize an extra distolingual (DL root in mandibular first molar may lead to incomplete debridement of the root canal system and eventually treatment failure. Therefore, it is crucial that atypical anatomy is identified before and during dental treatment. Spiral computed tomography (SCT images can show 3D images, and therefore much detail can be used when traditional methods prevent adequate endodontic treatment. The overall incidence of DL roots on the mandibular first molars was 6.40% for all patients and 5.00% for all teeth, respectively. The occurrence of DL roots on the right side and on the left side showed a statistically significant difference. The bilateral incidence of symmetrical distribution of DL roots was 56.25%. The DL root canal orifice was separated from DB canal orifice by 2.79±0.34 mm, from the MB canal orifice by 4.23±0.81 mm, and from the ML canal orifice by 3.29±0.52 mm. The high prevalence of the DL root in permanent mandibular first molars among the Indian population by using SCT and estimations of the interorifice distance of such teeth might be useful for successful endodontic treatments.

  7. The nature of premaximum halts of classical nova outbursts: V723 Cas and V463 Sct

    CERN Document Server

    Hachisu, Izumi

    2004-01-01

    We present a new interpretation of long premaximum halts of nova outbursts. For V723 Cas (Nova Cas 1995) and V463 Sct (Nova Sct 2000), we have reproduced light curves, excluding the brightness maxima, starting from the long premaximum halt through the late decay phase of the outbursts using a steady-state optically thick wind model. When the hydrogen-rich envelope of the white dwarf (WD) is massive enough, the star expands to \\sim 100 R_\\sun or over and its surface temperature decreases to below 7000 K. At this supergiant mimicry stage, the changes of the photospheric radius and temperature are both small against the large increase in the envelope mass. These make a saturation in visual magnitude for a long time before it begins to decline. It is the premaximum halts of classical nova outbursts. The visual magnitude during the saturation is close to the bolometric magnitude, which is an upper limit for a given WD mass. Since the WD masses are estimated to be 0.59 M_\\sun for V723 Cas and 1.1 M_\\sun for V463 Sc...

  8. Prevalence of Three-Rooted Mandibular First Molars among Indians Using SCT.

    Science.gov (United States)

    Garg, Amit Kumar; Tewari, Rajendra Kumar; Agrawal, Neha

    2013-01-01

    Undetected extra roots or root canals are a major reason for failure of endodontic treatment. Failure to recognize an extra distolingual (DL) root in mandibular first molar may lead to incomplete debridement of the root canal system and eventually treatment failure. Therefore, it is crucial that atypical anatomy is identified before and during dental treatment. Spiral computed tomography (SCT) images can show 3D images, and therefore much detail can be used when traditional methods prevent adequate endodontic treatment. The overall incidence of DL roots on the mandibular first molars was 6.40% for all patients and 5.00% for all teeth, respectively. The occurrence of DL roots on the right side and on the left side showed a statistically significant difference. The bilateral incidence of symmetrical distribution of DL roots was 56.25%. The DL root canal orifice was separated from DB canal orifice by 2.79 ± 0.34 mm, from the MB canal orifice by 4.23 ± 0.81 mm, and from the ML canal orifice by 3.29 ± 0.52 mm. The high prevalence of the DL root in permanent mandibular first molars among the Indian population by using SCT and estimations of the interorifice distance of such teeth might be useful for successful endodontic treatments.

  9. Epstein-Barr virus (EBV) reactivation is a frequent event after allogeneic stem cell transplantation (SCT) and quantitatively predicts EBV-lymphoproliferative disease following T-cell--depleted SCT

    NARCIS (Netherlands)

    van Esser, J W; van der Holt, B; Meijer, E; Niesters, H G; Trenschel, R; Thijsen, S F; van Loon, A M; Frassoni, F; Bacigalupo, A; Schaefer, U W; Osterhaus, A D; Gratama, J W; Löwenberg, B; Verdonck, L F; Cornelissen, J J

    2001-01-01

    Reactivation of the Epstein-Barr virus (EBV) after allogeneic stem cell transplantation (allo-SCT) may evoke a protective cellular immune response or may be complicated by the development of EBV-lymphoproliferative disease (EBV-LPD). So far, very little is known about the incidence, recurrence, and

  10. Revisiting The Brightest RV Tauri Star: First Ionization Potential (FIP) Effect in R Sct

    Science.gov (United States)

    Yolalan, Gizay; Sahin, Timur

    2016-07-01

    We have derived elemental abundances of the brightest RV Tauri star, R Sct. The abundance analysis of the star is based on high resolution and high quality (S/N>300) echelle spectra, mainly obtained for radial velocity study of a large sample of IRAS like RV Tau sample stars, from the McDonald Observatory (R~48,000). Our analysis is based on optical spectra obtained at only one phase of the variation. The standard 1D LTE analysis provided a fresh determination of the atmospheric parameters: Teff=5000 K, logg=1.05 cgs, and a microturbulence velocity ξ=3.4 km/s and [Fe/H] = -0.33. We report on chemical abundances of 10 neutral and ionized species identified over 4800 - 5600 A wavelength region. In an effort to explain observed deficiency in abundances, possible scenarios including FIP is investigated.

  11. KIC 3858884: a hybrid {\\delta} Sct pulsator in a highly eccentric eclipsing binary

    CERN Document Server

    Maceroni, C; da Silva, R; Montalbán, J; Lee, C -U; Ak, H; Deshpande, R; Yakut, K; Debosscher, J; Guo, Z; Kim, S -L; Lee, J W; Southworth, J

    2014-01-01

    The analysis of eclipsing binaries containing non-radial pulsators allows: i) to combine two different and independent sources of information on the internal structure and evolutionary status of the components, and ii) to study the effects of tidal forces on pulsations. KIC 3858884 is a bright Kepler target whose light curve shows deep eclipses, complex pulsation patterns with pulsation frequencies typical of {\\delta} Sct, and a highly eccentric orbit. We present the result of the analysis of Kepler photometry and of high resolution phaseresolved spectroscopy. Spectroscopy yielded both the radial velocity curves and, after spectral disentangling, the primary component effective temperature and metallicity, and line-of-sight projected rotational velocities. The Kepler light curve was analyzed with an iterative procedure devised to disentangle eclipses from pulsations which takes into account the visibility of the pulsating star during eclipses. The search for the best set of binary parameters was performed com...

  12. ATLAS-SCT end-cap module performance and status of production

    CERN Document Server

    Mangin-Brinet, M

    2004-01-01

    The LHC operating conditions present several challenges to the module performance of the ATLAS Semiconductor Tracker (SCT). This detector consists of four cylindrical barrel layers of silicon strip detectors and 18 disks in the forward and backward directions. Four different module designs exist, one for the barrel and three (inner, middle and outer) for the rings of the disks. A series of several end-cap module pre-production prototypes of inner, middle and outer types has been built and extensively characterized on single module test benches in the institutes of the collaboration. The purpose of this contribution is to summarize the electrical and thermal performance measurements made on these end-cap module pre-production prototypes.

  13. Amplitude Variability in gamma Dor and delta Sct Stars Observed by Kepler

    Energy Technology Data Exchange (ETDEWEB)

    Guzik, Joyce Ann [Los Alamos National Laboratory; Kosak, Mary Katherine [Los Alamos National Laboratory; Bradley, Paul Andrew [Los Alamos National Laboratory; Jackiewicz, Jason [New Mexico State University, Las Cruces, NM

    2015-08-17

    The NASA Kepler spacecraft data revealed a large number of new multimode nonradially pulsating gamma Dor and delta Sct variable stars. The Kepler high-precision long time-series photometry makes it possible to study amplitude variations of the frequencies, and recent literature on amplitude and frequency variations in nonradially pulsating variables is summarized. Several methods are applied to study amplitude variability in about a dozen gamma Doradus or delta Scuti candidate variable stars observed for several quarters as part of the Kepler Guest Observer program. The magnitude and timescale of the amplitude variations are discussed, along with the presence or absence of correlations between amplitude variations for different frequencies of a given star. Proposed causes of amplitude spectrum variability that will require further investigation are also discussed.

  14. Predictors of health-related quality of life in patients treated with auto- and allo-SCT for hematological malignancies

    NARCIS (Netherlands)

    prof Berno van Meijel; P.C. Huijgens; O. Visser; J. Dekker; A.T.F. Beekman; M.M.J.G. Gerrits; P. Cuijpers; A.M.J. Braamse; P. van Oppen; A.D. Boenink

    2011-01-01

    Identifying factors that predict health-related quality of life (QOL) following hematopoietic SCT, is important in estimating patients’ abilities to adjust to the consequences of their disease and treatment. As the studies that have been published on this subject are scattered, the present study

  15. Spectroscopic studies of three Cepheids with high positive pulsation period increments: SZ Cas, BY Cas, and RU Sct

    Science.gov (United States)

    Usenko, I. A.; Klochkova, V. G.

    2015-07-01

    Three high-resolution spectra have been taken at different times with the 6-m SAO RAS telescope (LYNX and PFES spectrographs) for three Cepheids exhibiting high positive period increments: the small-amplitude (DCEPS) SZ Cas and BY Cas and the classical (DCEP) RU Sct. SZ Cas and RU Sct are members of the Galactic open clusters χ and h Per and Trump 35, respectively. Analysis of the spectra has shown that the interstellar Na I D1 and D2 lines in all objects are considerably stronger than the atmospheric ones and are redshifted in SZ Cas and BY Cas and blushifted in RU Sct. The core of the H α absorption line in BY Cas has an asymmetric knifelike shape, while RU Sct exhibits an intense emission in the blue wing of this line. Such phenomena are observed in long-period Cepheids and bright hypergiants with an extended envelope. In this case, the strong Mg Ib 5183.62 Å and Ba II 5853.67, 6141.713, and 6496.90 Å lines with low χlow in SZ Cas and RU Sct also show characteristic knifelike profiles with an asymmetry in the red region, while the Ba II 4934.095 Å line shows similar profiles in the blue one. The absorption lines of neutral atoms and singly ionized metals with different lowerlevel excitation potentials exhibit different degrees of asymmetry: from a pronounced one with secondary components in BY Cas (similar to those in the small-amplitude Cepheid BG Cru pulsating in the first overtone and having an envelope) to its insignificance or virtual absence in SZ Cas and RU Sct. Analysis of the secular changes in mean T eff determined from photometric color indices and spectra over the last 55 years for these stars has revealed periodic fluctuations of 200 K for SZ Cas and BY Cas and 500 K for RU Sct. For SZ Cas and RU Sct, T eff determined in some years from some color indices show much lower values, which together with the temperature fluctuations can be associated with mass loss and dust formation. Based on these facts, we hypothesize the existence of

  16. Long-term event-free and overall survival after risk-adapted melphalan and SCT for systemic light chain amyloidosis

    Science.gov (United States)

    Landau, H; Smith, M; Landry, C; Chou, J F; Devlin, S M; Hassoun, H; Bello, C; Giralt, S; Comenzo, R L

    2017-01-01

    Stem cell transplantation (SCT), an effective therapy for amyloid light chain (AL) amyloidosis patients, is associated with low treatment-related mortality (TRM) with appropriate patient selection and risk-adapted dosing of melphalan (RA-SCT). Consolidation after SCT increases hematologic complete response (CR) rates and may improve overall survival (OS) for patients with SCT with or without consolidation. Melphalan was administered at 100 (14%), 140 (52%) and 200 (34%) mg/m2. The TRM rate at 100 days was 5%. RA-SCT resulted in CR in 24% (3 months) and 48% (12 months) of patients. The CR rate was particularly high (62%) in patients offered bortezomib consolidation. With a median follow-up among survivors of 7.7 years, median event-free survival (EFS) with RA-SCT was 4.04 years (95% confidence interval (CI): 3.41–5.01 years); median OS was 10.4 years (95% CI: 7.3–not achieved). Patients with CR at 12 months after SCT had significantly longer EFS (P=0.01) and OS (P=0.04). In a multivariate analysis, melphalan dose had no impact on EFS (P=0.26) or OS (P=0.11). For selected patients, RA-SCT was safe and was associated with extended long-term survival. With the availability of novel agents for consolidation, RA-SCT remains a very effective and important backbone treatment for AL amyloidosis. PMID:27560108

  17. Prophylactic G-CSF mobilized donor lymphocytes infusion after non-myeloablative stem cell transplantation prevents relapse in patients with high-risk leukemia%预防性G-CSF动员后供者淋巴细胞输注对高危白血病患者非清髓造血干细胞移植术后复发及移植物抗宿主病的影响

    Institute of Scientific and Technical Information of China (English)

    赵红霞; 孙万军; 李洁; 乔均晓; 黄雅静; 胡海兰; 艾辉胜

    2013-01-01

    Objective To evaluate the anti-leukemia effects of prophylactic G-CSF mobilized donor lymphocytes infusion (pG-DLI) and its relationship with the incidence of graft-versus-host disease (GVHD) in high-risk leukemia patients with non-myeloblative stem cell transplantation (NST).Methods 12 patients with high-risk leukemia were analyzed,including Ph+ acute lymphocytic leukemia (n=1),acute leukemia (AL) with persistent non-complete remission (n=2),acute myeloid leukemia (AML) with central nervous system (CNS) relapse (n=3),hybrid AL (n=1),secondary AML evolving from myelodysplastic syndrome (MDS/AML) (n=2),chronic myeloid leukemia in accelerated phase (CML-AP) (n=1),CML in blastic phase (CML-BP) (n=2).All patients received non-myeloablative conditioning and pG-DLIs were administered 30-40 days post transplantation if no signs of GVHD were present.The percentage of donor cell chimera was analyzed by short tandem repeat-polymerase chain reaction (STR-PCR) just before and after pG-DLI.The incidence of leukemia relapse and GVHD were observed.Results 12 high-risk leukemia patients with a median age of 38 (range:29-52) years received pG-DLI at a median interval of 35 (32-40) days.The median numbers of infused mononuclear cells (MNCs),CD34+,and CD3+ cells/kg recipient body weight was 2.3× 108/kg,1.7× 106/kg,and 0.6× 108/kg,respectively.10 of 12 patients had full donor chimera before pG-DLIs and conversion from mixed to full donor chimera occurred in the other 2 patients shortly after pG-DLI.Grade Ⅱ acute GVHD (aGVHD) was observed in only 2 patients and chronic GVHD (cGVHD) developed in 6 patients,including involvement of skin (n=3),skin and intestine (n=2),liver (n=1).1 patient died of cGVHD.With a median follow-up of 40 (24-64) months,7 patients are alive in remission,with 3-year actuarial overall survival (OS) and disease-free survival (DFS) rates of the same 58.3%.Conclusion Our findings indicate that pG-DLI after NST does not increase the risk of aGVHD,but could

  18. High-resolution Spectroscopy and Spectropolarimetry of Selected δ-Sct Pulsating Variables

    Science.gov (United States)

    Joshi, Santosh; Semenko, Eugene; Moiseeva, A.; Sharma, Kaushal; Joshi, Y. C.; Sachkov, M.; Singh, Harinder P.; Kumar, Yerra Bharat

    2017-01-01

    The combination of photometry, spectroscopy and spectropolarimetry of the chemically peculiar stars often aims to study the complex physical phenomena such as stellar pulsation, chemical inhomogeneity, magnetic field and their interplay with stellar atmosphere and circumstellar environment. The prime objective of the present study is to determine the atmospheric parameters of a set of Am stars to understand their evolutionary status. Atmospheric abundances and basic parameters are determined using full spectrum fitting technique by comparing the high-resolution spectra to the synthetic spectra. To know the evolutionary status we derive the effective temperature and luminosity from different methods and compare them with the literature. The location of these stars in the H-R diagram demonstrate that all the sample stars are evolved from the Zero-Age-Main-Sequence towards Terminal-Age-Main-Sequence and occupy the region of δ Sct instability strip. The abundance analysis shows that the light elements e.g. Ca and Sc are underabundant while iron peak elements such as Ba, Ce etc. are overabundant and these chemical properties are typical for Am stars. The results obtained from the spectropolarimetric analysis shows that the longitudinal magnetic fields in all the studied stars are negligible that gives further support their Am class of peculiarity.

  19. Allo-SCT conditioning for myelodysplastic syndrome and acute myeloid leukemia with clofarabine, cytarabine and ATG.

    Science.gov (United States)

    Martin, M G; Uy, G L; Procknow, E; Stockerl-Goldstein, K; Cashen, A; Westervelt, P; Abboud, C N; Augustin, K; Luo, J; DiPersio, J F; Vij, R

    2009-07-01

    The application of myeloablative Allo-SCT is limited by its associated morbidity and mortality. Reduced-intensity conditioning regimens attempt to diminish these, but are associated with a higher risk of disease relapse. Given the evidence of activity of clofarabine and cytarabine in myelodysplastic syndrome/acute myeloid leukemia (MDS/AML), we explored a novel reduced-intensity conditioning regimen based on this backbone. Patients received clofarabine 40 mg/m(2) i.v. on days -6 to -2, cytarabine 1 g/m(2) i.v. on days -6 to -2 and anti-thymocyte globulin (ATG) 1 mg/kg on day -4 and 2.5 mg/kg x 2 days on days -3 and -2. Seven patients were enrolled. Their median age was 54 years; three were with MDS and four with AML. The median duration of neutropenia was 14 days and that of thrombocytopenia was 22 days. Toxicities included hand-foot syndrome (57% grade 2), elevated alanine aminotransferase (ALT) (57% grade 3), elevated aspartate aminotransferase (AST) (86% grade 3) and hyperbilirubinemia (29% grade 3-5). No acute GVHD was observed. Enrollment to the trial was halted after three of the first seven patients expired on days +15, +26 and +32. Three of the four surviving patients have relapsed with a median TTP of 152 days. This regimen was not sufficiently immunosuppressive to ensure engraftment, and was associated with substantial morbidity and mortality.

  20. Synthesis gas/H{sub 2} via SCT-CPO. A pilot-plant experience

    Energy Technology Data Exchange (ETDEWEB)

    Basini, L.; Cimino, R.; Guarinoni, A. [Eni S.p.A., Divisione Refining and Marketing, Direzione Ricerca e Sviluppo Tecnologico, San Donato Milanese (Italy); Campanelli, G.; Ficili, C.; Ponzo, R. [Eni S.p.A., Divisione Refining and Marketing, Direzione Ricerca e Sviluppo Tecnologico, San Filippo del Mela (Italy)

    2006-07-01

    Hydrogen and Synthesis Gas have been extensively utilised for more than 70 years in chemical and refinery industries. Their uses are becoming today more complex being influenced by strategic, political, economic and sustainability considerations. Clean fuel production and heavy residues utilisation, Gas To Liquid initiatives and the desired but not yet accomplished Electric Energy production with Fuel Cells, are issues whose development and costs would benefit from innovations in Hydrogen and Synthesis Gas production and utilisation. The existing technological needs will be briefly discussed considering a new H{sub 2}/Synthesis gas production method, the Short Contact Time - Catalytic Partial Oxidation (SCT-CPO). This has been studied since the early '90es by performing an extensive work at lab-scale and in bench scale levels and finally scaling-up the technology. In 2001 Snamprogetti (the engineering company of the ENI group) and Haldor Topsoe A/S successfully operated a first pilot plant in Houston, TX and in 2005 EniTecnologie realised and operated a second multi-purpose plant in Milazzo, Sicily. The multi-purpose plant includes all the main operation units of an industrial realisation and allows a full simulation of real conditions. Moreover it is designed to process a wide class of hydrocarbons (ranging from NG to liquid and heavy fuels). This work reviews its features and capabilities of providing useful information for the development of technological applications. (orig.)

  1. High-resolution Spectroscopy and Spectropolarimetry of Selected δ-Sct Pulsating Variables

    Science.gov (United States)

    Joshi, Santosh; Semenko, Eugene; Moiseeva, A.; Sharma, Kaushal; Joshi, Y. C.; Sachkov, M.; Singh, Harinder P.; Yerra, Bharat Kumar

    2017-05-01

    The combination of photometry, spectroscopy and spectropolarimetry of the chemically peculiar stars often aims to study the complex physical phenomena such as stellar pulsation, chemical inhomogeneity, magnetic field and their interplay with stellar atmosphere and circumstellar environment. The prime objective of this study is to determine the atmospheric parameters of a set of Am stars to understand their evolutionary status. Atmospheric abundances and basic parameters are determined using full spectrum fitting technique by comparing the high-resolution spectra to the synthetic spectra. To know the evolutionary status, we derive the effective temperature and luminosity from different methods and compare them with the literature. The location of these stars in the Hertzsprung-Russell diagram demonstrates that all the sample stars are evolved from the zero-age main sequence towards terminal-age main sequence and occupy the region of δ Sct instability strip. The abundance analysis shows that the light elements e.g. Ca and Sc are underabundant while iron peak elements such as Ba, Ce, etc. are overabundant and these chemical properties are typical for Am stars. The results obtained from the spectropolarimetric analysis of our studied stars show that the longitudinal magnetic field is negligible in all of them, which further support to their Am class of peculiarity.

  2. Outcomes of hematopoietic SCT recipients with rhinovirus infection: a matched, case-control study.

    Science.gov (United States)

    Abandeh, F I; Lustberg, M; Devine, S; Elder, P; Andritsos, L; Martin, S I

    2013-11-01

    The impact of rhinovirus in hematopoietic SCT (HSCT) recipients is not well defined. A retrospective, matched, case-control study of HSCT recipients with rhinovirus was conducted between 2009 and 2011. Controls were matched for timing relative to transplant, malignancy, and stem cell source. There were 47 cases and 94 controls. The cases and controls did not differ with respect to age, gender, ethnicity, donor source, malignancy, conditioning regimen, immunosuppression, antimicrobial prophylaxis or significant comorbidities. There were no differences in need for intensive care unit care, 100 day mortality, hospice discharge, relapse of disease, GVHD or development of disease or infection due to CMV or EBV. Other infectious complications after rhinovirus diagnosis were also equal. However, there was an increased number of recurrent hospitalizations from any cause among the cases (46.8% vs 24.5%, P=0.007). Recurrent hospitalizations due to any infection were also more common in cases (34% vs 14.9%, P=0.015). For patients who were diagnosed with rhinovirus pre-transplant (n=13), there was no difference in outcome compared with matched controls. HSCT recipients with rhinovirus have an increased risk of hospital readmission. However, there was no difference in outcome compared with matched controls. Transplantation in patients with active rhinovirus infection appears to be safe.

  3. Sporadic late-onset nemaline myopathy with MGUS: long-term follow-up after melphalan and SCT.

    OpenAIRE

    Voermans, Nicol C.; Benveniste, Olivier; Minnema, Monique C.; Lokhorst, Henk; Lammens, Martin; Meersseman, Wouter; Delforge, Michel; Kuntzer, Thierry; Novy, Jan; Pabst, Thomas; Bouhour, Françoise; Romero, Norma; Leblond, Veronique; Bergh, Peter van den; Vekemans, Marie-Christiane

    2014-01-01

    OBJECTIVE Sporadic late-onset nemaline myopathy (SLONM) is a rare, late-onset myopathy that progresses subacutely. If associated with a monoclonal gammopathy of unknown significance (MGUS), the outcome is unfavorable: the majority of these patients die within 1 to 5 years of respiratory failure. This study aims to qualitatively assess the long-term treatment effect of high-dose melphalan (HDM) followed by autologous stem cell transplantation (SCT) in a series of 8 patients with SLONM-MGUS...

  4. New-onset microalbuminuria following allogeneic myeloablative SCT is a sign of near-term decrease in renal function.

    Science.gov (United States)

    Morito, T; Ando, M; Kobayashi, T; Kakihana, K; Ohashi, K; Akiyama, H; Tsuchiya, K; Nitta, K; Sakamaki, H

    2013-07-01

    The emergence of microalbuminuria following conditioning chemotherapy may predict the development of renal dysfunction. To confirm this, a 1-year retrospective cohort study was conducted in 31 myeloablative allogeneic SCT patients who received five consecutive measurements of albuminuria before conditioning therapy and on days 0, 7, 14 and 28 following SCT. The cohort had neither microalbuminuria nor renal dysfunction at baseline. Microalbuminuria was defined as an albumin-creatinine (Cr) ratio over 30 mg/g, and renal dysfunction was as an estimated glomerular filtration rate microalbuminuria with the incidence of renal dysfunction. In all, 16 patients (52%) developed microalbuminuria that was positive at least two times among the four measurements after SCT. The actuarial occurrence of chronic kidney disease was significantly higher in patients who developed microalbuminuria than in those who did not. Incidence of microalbuminuria had a significant risk of subsequent renal dysfunction (hazard ratio (95% confidence interval), 7.3 (1.2-140)). In conclusion, de novo microalbuminuria following conditioning therapy is a warning of near-term loss of renal function.

  5. Early relapse after single auto-SCT for multiple myeloma is a major predictor of survival in the era of novel agents.

    Science.gov (United States)

    Jimenez-Zepeda, V H; Reece, D E; Trudel, S; Chen, C; Tiedemann, R; Kukreti, V

    2015-02-01

    The role of auto-SCT in the treatment of multiple myeloma (MM) in the era of novel agents continues to evolve. It is now clear that the depth of response and clinical outcomes have significantly improved as a result of the combination of these strategies. However, not all patients with MM who undergo auto-SCT are able to sustain a meaningful response and 20% of patients relapse shortly after auto-SCT. In this study, we aimed to assess the impact of early relapse (ER) after auto-SCT on OS for MM patients undergoing single auto-SCT who had received novel agent-based induction regimens. All consecutive patients with MM undergoing single auto-SCT from January 2002 to September 2012 who had novel induction therapy were evaluated. A total of 184 patients were identified. The median OS and PFS for the group of transplanted patients were 93 and 25.4 months, respectively. Median time to relapse was 17.2 months with 40% having relapsed at the time of analysis. ER (auto-SCT) was seen in 27 (36%) out of 75 patients who had relapsed, and median OS was significantly shorter than in those with non-ER. Multivariate analysis showed ER as the major independent prognostic factor for OS. On the basis of these findings, we conclude that not only attainment of a good response, but sustainability of it, appears to be a major prognostic variable in MM in the era of novel therapy. Patients with ER post auto-SCT should biologically be characterized in prospective studies to better understand the mechanisms of resistance associated with this particular entity.

  6. ECIL recommendations for the use of biological markers for the diagnosis of invasive fungal diseases in leukemic patients and hematopoietic SCT recipients.

    Science.gov (United States)

    Marchetti, O; Lamoth, F; Mikulska, M; Viscoli, C; Verweij, P; Bretagne, S

    2012-06-01

    As culture-based methods for the diagnosis of invasive fungal diseases (IFD) in leukemia and hematopoietic SCT patients have limited performance, non-culture methods are increasingly being used. The third European Conference on Infections in Leukemia (ECIL-3) meeting aimed at establishing evidence-based recommendations for the use of biological tests in adult patients, based on the grading system of the Infectious Diseases Society of America. The following biomarkers were investigated as screening tests: galactomannan (GM) for invasive aspergillosis (IA); β-glucan (BG) for invasive candidiasis (IC) and IA; Cryptococcus Ag for cryptococcosis; mannan (Mn) Ag/anti-mannan (A-Mn) Ab for IC, and PCR for IA. Testing for GM, Cryptococcus Ag and BG are included in the revised EORTC/MSG (European Organization for Research and Treatment of Cancer/Mycoses Study Group) consensus definitions for IFD. Strong evidence supports the use of GM in serum (A II), and Cryptococcus Ag in serum and cerebrospinal fluid (CSF) (A II). Evidence is moderate for BG detection in serum (B II), and the combined Mn/A-Mn testing in serum for hepatosplenic candidiasis (B III) and candidemia (C II). No recommendations were formulated for the use of PCR owing to a lack of standardization and clinical validation. Clinical utility of these markers for the early management of IFD should be further assessed in prospective randomized interventional studies.

  7. Modified high-dose melphalan and autologous SCT for AL amyloidosis or high-risk myeloma: analysis of SWOG trial S0115

    Science.gov (United States)

    Sanchorawala, V; Hoering, A; Seldin, DC; Finn, KT; Fennessey, SA; Sexton, R; Mattar, B; Safah, HF; Holmberg, LA; Dean, RM; Orlowski, RZ; Barlogie, B

    2013-01-01

    We designed a trial using two sequential cycles of modified high-dose melphalan at 100 mg/m2 and autologous SCT (mHDM/SCT) in AL amyloidosis (light-chain amyloidosis, AL), AL with myeloma (ALM) and host-based high-risk myeloma (hM) patients through SWOG-0115. The primary objective was to evaluate OS. From 2004 to 2010, 93 eligible patients were enrolled at 17 centers in the United States (59 with AL, 9 with ALM and 25 with hM). The median OS for patients with AL and ALM was 68 months and 47 months, respectively, and has not been reached for patients with hM. The median PFS for patients with AL and ALM was 38 months and 16 months, respectively, and has not been reached for patients with hM. The treatment-related mortality (TRM) was 12% (11/ 93) and was observed only in patients with AL after SCT. Grade 3 and higher non-hematologic adverse events were experienced by 81%, 67% and 57% of patients with AL, ALM and hM, respectively, during the first and second HDM/SCT. This experience demonstrates that with careful selection of patients and use of mHDM for SCT in patients with AL, ALM and hM, even in the setting of a multicenter study, OS can be improved with acceptable TRM and morbidity. PMID:23852321

  8. Radiation hardness and lifetime studies of LEDs and VCSELs for the optical readout of the ATLAS SCT

    CERN Document Server

    Beringer, J; Mommsen, R K; Nickerson, R B; Weidberg, A R; Monnier, E; Hou, H Q; Lear, K L

    1999-01-01

    We study the radiation hardness and the lifetime of Light Emitting Diodes (LEDs) and Vertical Cavity Surface Emitting Laser diodes (VCSELs) in the context of the development of the optical readout for the ATLAS SemiConductor Tracker (SCT) at LHC. About 170 LEDs from two different manufacturers and about 130 VCSELs were irradiated with neutron and proton fluences equivalent to (and in some cases more than twice as high as) the combined neutral and charged particle fluence of about 5x10 sup 1 sup 4 n (1 MeV eq. in GaAs)/cm sup 2 expected in the ATLAS inner detector. We report on the radiation damage and the conditions required for its partial annealing under forward bias, we calculate radiation damage constants, and we present post-irradiation failure rates for LEDs and VCSELs. The lifetime after irradiation was investigated by operating the diodes at an elevated temperature of 50 degree sign C for several months, resulting in operating times corresponding to up to 70 years of operation in the ATLAS SCT. From o...

  9. Laser characterisation of a 3D single-type column p-type prototype module read out with ATLAS SCT electronics

    Energy Technology Data Exchange (ETDEWEB)

    Ehrich, T. [Physikalisches Institut, Universitaet Freiburg, Hermann-Herder Str. 3, 79104 Freiburg (Germany); Kuehn, S. [Physikalisches Institut, Universitaet Freiburg, Hermann-Herder Str. 3, 79104 Freiburg (Germany)], E-mail: susanne.kuehn@physik.uni-freiburg.de; Boscardin, M.; Dalla Betta, G.-F. [ITC-irst Trento, Microsystems Division, via Sommarive, 18 38050 Povo di Trento (Italy); Eckert, S.; Jakobs, K.; Maassen, M.; Parzefall, U. [Physikalisches Institut, Universitaet Freiburg, Hermann-Herder Str. 3, 79104 Freiburg (Germany); Piemonte, C.; Pozza, A.; Ronchin, S.; Zorzi, N. [ITC-irst Trento, Microsystems Division, via Sommarive, 18 38050 Povo di Trento (Italy)

    2007-12-11

    In this paper measurements of a 3D single-type column (3D-stc) microstrip silicon device are shown. The 3D-stc sensor has n-type columns in p-type substrate. It has been connected to an ATLAS SCT ABCD3T chip and is readout with ATLAS SCT electronics at 40 MHz. Spatial measurements were done with a laser setup to investigate the expected low field region in 3D devices. An influence of the p-stops on the collected charge has been observed.

  10. Application of Cu-polyimide flex circuit and Al-on-glass pitch adapter for the ATLAS SCT barrel hybrid

    CERN Document Server

    Unno, Y; Ikegami, Y; Iwata, Y; Kohriki, T; Kondo, T; Nakano, I; Ohsugi, T; Takashima, R; Tanaka, R; Terada, S; Ujiie, N

    2005-01-01

    We applied the surface build-up Cu-polyimide flex-circuit technology with laser vias to the ATLAS SCT barrel hybrid to be made in one piece from the connector to the electronics sections including cables. The hybrids, reinforced with carbon-carbon substrates, provide mechanical strength, thermal conductivity, low-radiation length, and stability in application-specific integrated circuit (ASIC) operation. By following the design rules, we experienced little trouble in breaking the traces. The pitch adapter between the sensor and the ASICs was made of aluminum traces on glass substrate. We identified that the generation of whiskers around the wire-bonding feet was correlated with the hardness of metallized aluminum. The appropriate hardness has been achieved by keeping the temperature of the glasses as low as room temperature during the metallization. The argon plasma cleaning procedure cleaned the contamination on the gold pads of the hybrids for successful wire bonding, although it was unsuccessful in the alu...

  11. Rapid Recovery from Chronic PRCA by MSC Infusion in Patient after Major ABO-Mismatched alloSCT

    Directory of Open Access Journals (Sweden)

    Vera Sergeevicheva

    2012-01-01

    Full Text Available Pure red cell aplasia (PRCA is a rare complication in recipients of allogenic stem cell from ABO incompatible donors. It is characterized by reticulocytopenia and by an absence of red cell cell precursors in the bone marrow. Despite close isohemagglutinins monitoring and standard immunosupressive treatment in these patients prolong PRCA are still associated with severe transfusion dependence. We report the case of a 31 yr old male patient who underwent HLA-matched ABO-mismatched allo-SCT and developed resistance PRCA despite conventional immunosupressive therapy and prophylaxis cotrasplantation of bone marrow derived MSC at day 0. He responded dramatically to therapy with adipose tissue derived mesenchymal stem cells from HSC donors and continued to be transfusion-independent and AML-disease free. This method of the PRCA therapy of deserves further investigation.

  12. The impact of center experience on results of reduced intensity : allogeneic hematopoietic SCT for AML. An analysis from the Acute Leukemia Working Party of the EBMT

    NARCIS (Netherlands)

    Giebel, S.; Labopin, M.; Mohty, M.; Mufti, G. J.; Niederwieser, D.; Cornelissen, J. J.; Janssen, J. J. W. M.; Milpied, N.; Vindelov, L.; Petersen, E.; Arnold, R.; Bacigalupo, A.; Blaise, D.; Craddock, C.; Nagler, A.; Frassoni, F.; Sadus-Wojciechowska, M.; Rocha, V.

    2013-01-01

    Allogeneic hematopoietic SCT with reduced-intensity conditioning (RIC-HSCT) is increasingly adopted for the treatment of older adults with AML. Our goal was to verify for the first time, if center experience influences outcome of RIC-HSCT. Results of 1413 transplantations from HLA-matched related or

  13. The impact of center experience on results of reduced intensity:allogeneic hematopoietic SCT for AML. An analysis from the Acute Leukemia Working Party of the EBMT

    DEFF Research Database (Denmark)

    Giebel, S; Labopin, M; Mohty, M

    2013-01-01

    Allogeneic hematopoietic SCT with reduced-intensity conditioning (RIC-HSCT) is increasingly adopted for the treatment of older adults with AML. Our goal was to verify for the first time, if center experience influences outcome of RIC-HSCT. Results of 1413 transplantations from HLA-matched related...

  14. NMR investigations of structural and dynamics features of natively unstructured drug peptide - salmon calcitonin: implication to rational design of potent sCT analogs.

    Science.gov (United States)

    Rawat, Atul; Kumar, Dinesh

    2013-01-01

    Backbone dynamics and conformational properties of drug peptide salmon calcitonin have been studied in aqueous solution using nuclear magnetic resonance (NMR). Although salmon calcitonin (sCT) is largely unfolded in solution (as has been reported in several circular dichroism studies), the secondary H(α) chemical shifts and three bond H(N) -H(α) coupling constants indicated that most of the residues of the peptide are populating the α-helical region of the Ramachandran (ϕ, ψ) map. Further, the peptide in solution has been found to exhibit multiple conformational states exchanging slowly on the NMR timescale (10(2) -10(3)  s(-1) ), inferred by the multiple chemical shift assignments in the region Leu4-Leu12 and around Pro23 (for residues Gln20-Tyr22 and Arg24). Possibly, these slowly exchanging multiple conformational states might inhibit symmetric self-association of the peptide and, in part, may account for its reduced aggregation propensity compared with human calcitonin (which lacks this property). The (15) N NMR-relaxation data revealed (i) the presence of slow (microsecond-to-millisecond) timescale dynamics in the N-terminal region (Cys1-Ser5) and core residues His17 and Asn26 and (ii) the presence of high frequency (nanosecond-to-picosecond) motions in the C-terminal arm. Put together, the various results suggested that (i) the flexible C-terminal of sCT (from Thr25-Thr31) is involved in identification of specific target receptors, (ii) whereas the N-terminal of sCT (from Cys1-Gln20) in solution - exhibiting significant amount of conformational plasticity and strong bias towards biologically active α-helical structure - facilitates favorable conformational adaptations while interacting with the intermembrane domains of these target receptors. Thus, we believe that the structural and dynamics features of sCT presented here will be useful guiding attributes for the rational design of biologically active sCT analogs.

  15. Factors affecting the development of atrial fibrillation and atrial flutter (AF/AFL) following autologous hematopoietic SCT (auto-HSCT).

    Science.gov (United States)

    Steuter, J A; Villanueva, M L H; Loberiza, F R; Armitage, J O; Bociek, R G; Ganti, A K; Tarantolo, S R; Vose, J M; Easley, A; Bierman, P J

    2013-07-01

    The use of autologous hematopoietic SCT (auto-HSCT) has expanded to include older patients. Increasing age is a well-appreciated risk factor for the development of atrial fibrillation and/or atrial flutter (AF/AFL) in the general population. As more elderly patients undergo auto-HSCT, the risk of developing AF/AFL post transplant may also increase. However, few data evaluating other risk factors for the development of AF/AFL following auto-HSCT exist. Therefore, we performed a retrospective study to determine the incidence of AF/AFL following auto-HSCT and to determine the risk factors associated with the development of AF/AFL. Patients who developed AF/AFL were compared with a group of patients who received auto-HSCT within the same time period (April 1999 to May 2005) and were within 5 years of age. Of the 516 patients who underwent auto-HSCT at the University of Nebraska Medical Center 44 (8.5%) developed AF/AFL at a median time of 4 days (range, days 1-9) following auto-HSCT. In multivariate analysis, risk factors for developing AF/AFL were older age, odds ratio and 95% CI of 1.14 (1.07-1.21), elevated serum creatinine level, 2.69 (1.00-7.22), history of previous arrhythmia, 9.33 (3.01-28.99), and history of previous mediastinal irradiation, 11.12 (1.33-92.96).

  16. A prospective randomized controlled trial comparing PCR-based and empirical treatment with liposomal amphotericin B in patients after allo-SCT.

    Science.gov (United States)

    Hebart, H; Klingspor, L; Klingebiel, T; Loeffler, J; Tollemar, J; Ljungman, P; Wandt, H; Schaefer-Eckart, K; Dornbusch, H J; Meisner, C; Engel, C; Stenger, N; Mayer, T; Ringden, O; Einsele, H

    2009-04-01

    We compared the efficacy and safety of empirical plus PCR-based vs empirical liposomal amphotericin B treatment after Allo-SCT. Allo-SCT recipients were randomized to receive either PCR-based preemptive therapy (group A; n=198) or empirical antifungal therapy (group B; n=211) with liposomal amphotericin B. In group A, therapy was started after one positive PCR result or after 120 h of febrile neutropenia refractory to broad-spectrum antibacterial therapy. In group B, liposomal amphotericin B was started after 120 h of refractory febrile neutropenia. Demographic and clinical characteristics were well balanced. A total of 112 (57.1%) patients in group A and 76 (36.7%) patients in group B received antifungal therapy (P<0.0001). Twelve patients in group A and 16 patients in group B developed proven invasive fungal infection (IFI). Survival curves showed better survival until day 30 when close PCR monitoring was performed (mortality 1.5 vs 6.3%; P=0.015), but there was no difference at day 100. At day 100, no difference was observed in the incidence of IFI (primary end point) and survival between the two arms. Further studies are required to assess the benefit of using PCR in patients after SCT.

  17. Use of G-CSF to hasten neutrophil recovery after auto-SCT for AML is not associated with increased relapse incidence: a report from the Acute Leukemia Working Party of the EBMT.

    Science.gov (United States)

    Czerw, T; Labopin, M; Gorin, N-C; Giebel, S; Blaise, D; Dumas, P-Y; Foa, R; Attal, M; Schaap, N; Michallet, M; Bonmati, C; Veelken, H; Mohty, M

    2014-07-01

    Application of G-CSF in AML is controversial as leukemic blasts may express receptors interacting with the cytokine, which may stimulate leukemia growth. We retrospectively analyzed the impact of G-CSF use to accelerate neutrophil recovery after auto-SCT on outcome. Adults with AML in first CR autografted between 1994 and 2010 were included. Nine hundred and seventy two patients were treated with G-CSF after auto-SCT whereas 1121 were not. BM and PB were used as a source of stem cells in 454 (22%) and 1639 (78%) cases, respectively. The incidence of relapse at 5 years in the BM-auto-SCT group was 38% for patients receiving post-transplant G-CSF and 43% for those not treated with G-CSF, P=0.46. In the PB-auto-SCT cohort, respective probabilities were 48% and 49%, P=0.49. No impact of the use of G-CSF could be demonstrated with respect to the probability of leukemia-free survival: in the BM-auto-SCT group, 51% for G-CSF(+) and 48% for G-CSF(-), P=0.73; in PB-auto-SCT group, 42% for G-CSF(+) and 43% for G-CSF(-), P=0.83. Although G-CSF administration significantly shortened the neutropenic phase, no beneficial effect was observed with regard to non-relapse mortality. In patients with AML, the use of G-CSF after auto-SCT is not associated with increased risk of relapse irrespective of the source of stem cells used.

  18. Adoptive Cell Transfer Therapy Following Non-Myeloablative but Lymphodepleting Chemotherapy for the Treatment of Patients With Refractory Metastatic Melanoma

    National Research Council Canada - National Science Library

    Mark E. Dudley; John R. Wunderlich; James C. Yang; Richard M. Sherry; Suzanne L. Topalian; Nicholas P. Restifo; Richard E. Royal; Udai Kammula; Don E. White; Sharon A. Mavroukakis; Linda J. Rogers; Gerald J. Gracia; Stephanie A. Jones; David P. Mangiameli; Michelle M. Pelletier; Juan Gea-Banacloche; Michael R. Robinson; David M. Berman; Armando C. Filie; Andrea Abati; Steven A. Rosenberg

    2005-01-01

    We investigated the combination of lymphodepleting chemotherapy followed by the adoptive transfer of autologous tumor reactive lymphocytes for the treatment of patients with refractory metastatic melanoma...

  19. Adoptive Cell Transfer Therapy Following Non-Myeloablative but Lymphodepleting Chemotherapy for the Treatment of Patients With Refractory Metastatic Melanoma

    Science.gov (United States)

    Dudley, Mark E.; Wunderlich, John R.; Yang, James C.; Sherry, Richard M.; Topalian, Suzanne L.; Restifo, Nicholas P.; Royal, Richard E.; Kammula, Udai; White, Don E.; Mavroukakis, Sharon A.; Rogers, Linda J.; Gracia, Gerald J.; Jones, Stephanie A.; Mangiameli, David P.; Pelletier, Michelle M.; Gea-Banacloche, Juan; Robinson, Michael R.; Berman, David M.; Filie, Armando C.; Abati, Andrea; Rosenberg, Steven A.

    2006-01-01

    Purpose We investigated the combination of lymphodepleting chemotherapy followed by the adoptive transfer of autologous tumor reactive lymphocytes for the treatment of patients with refractory metastatic melanoma. Patients and Methods Thirty-five patients with metastatic melanoma, all but one with disease refractory to treatment with high-dose interleukin (IL)-2 and many with progressive disease after chemotherapy, underwent lymphodepleting conditioning with two days of cyclophosphamide (60 mg/kg) followed by five days of fludarabine (25 mg/m2). On the day following the final dose of fludarabine, all patients received cell infusion with autologous tumor-reactive, rapidly expanded tumor infiltrating lymphocyte cultures and high-dose IL-2 therapy. Results Eighteen (51%) of 35 treated patients experienced objective clinical responses including three ongoing complete responses and 15 partial responses with a mean duration of 11.5 ± 2.2 months. Sites of regression included metastases to lung, liver, lymph nodes, brain, and cutaneous and subcutaneous tissues. Toxicities of treatment included the expected hematologic toxicities of chemotherapy including neutropenia, thrombocytopenia, and lymphopenia, the transient toxicities of high-dose IL-2 therapy, two patients who developed Pneumocystis pneumonia and one patient who developed an Epstein-Barr virus-related lymphoproliferation. Conclusion Lymphodepleting chemotherapy followed by the transfer of highly avid antitumor lymphocytes can mediate significant tumor regression in heavily pretreated patients with IL-2 refractory metastatic melanoma. PMID:15800326

  20. The tip of the iceberg: the frequency content of the δ Sct star HD 50844 from CoRoT space photometry

    Science.gov (United States)

    Poretti, E.; Mantegazza, L.; Rainer, M.; Uytterhoeven, K.; Michel, E.; Baglin, A.; Auvergne, M.; Catala, C.; Samadi, R.; Rodríguez, E.; Garrido, R.; Amado, P.; Martín-Ruiz, S.; Moya, A.; Suárez, J. C.; Baudin, F.; Zima, W.; Alvarez, M.; Mathias, P.; Paparó, M.; Pápics, P.; Plachy, E.

    2009-09-01

    It has been suggested that the detection of a wealth of very low amplitude modes in δ Sct stars was only a matter of signal-to-noise ratio. Access to this treasure, impossible from the ground, is one of the scientific aims of the space mission CoRoT, developed and operated by CNES. This work presents the results obtained on HD 50844: the 140,016 datapoints allowed us to reach the level of 10-5 mag in the amplitude spectra. The frequency analysis of the CoRoT timeseries revealed hundreds of terms in the frequency range 0-30 d-1. The initial guess that δ Sct stars have a very rich frequency content is confirmed. The spectroscopic mode identification gives theoretical support since very high-degree modes (up to = 14) are identified. We also prove that cancellation effects are not sufficient in removing the flux variations associated to these modes at the noise level of the CoRoT measurements. The ground-based observations indicate that HD 50844 is an evolved star that is slightly underabundant in heavy elements, located on the Terminal Age Main Sequence. The predominant term (f1 = 6.92 d-1) has been identified as the fundamental radial mode combining ground-based photometric and spectroscopic data.

  1. The tip of the iceberg: the frequency content of the Delta Sct star HD 50844 from CoRoT space photometry

    CERN Document Server

    Poretti, E; Rainer, M; Uytterhoeven, K; Michel, E; Baglin, A; Auvergne, M; Catala, C; Samadi, R; Rodríguez, E; Garrido, R; Amado, P; Martin-Ruiz, S; Moya, A; Suarez, C; Baudin, F; Zima, W; Alvarez, M; Mathias, P; Paparo, M; Papics, P; Plachy, E

    2009-01-01

    It has been suggested that the detection of a wealth of very low amplitude modes in Delta Sct stars was only a matter of signal--to--noise ratio. Access to this treasure, impossible from the ground, is one of the scientific aims of the space mission CoRoT, developed and operated by CNES. This work presents the results obtained on HD 50844: the 140,016 datapoints allowed us to reach the level of 10^{-5} mag in the amplitude spectra. The frequency analysis of the CoRoT timeseries revealed hundreds of terms in the frequency range 0--30 d^{-1}. The initial guess that Delta Sct stars have a very rich frequency content is confirmed. The spectroscopic mode identification gives theoretical support since very high--degree modes (up to ell=14) are identified. We also prove that cancellation effects are not sufficient in removing the flux variations associated to these modes at the noise level of the CoRoT measurements. The ground--based observations indicate that HD 50844 is an evolved star that is slightly underabunda...

  2. Comparison of umbilical cord blood allogeneic stem cell transplantation vs. auto-SCT for adult acute myeloid leukemia patients in second complete remission at transplant: a retrospective study on behalf of the SFGM-TC.

    Science.gov (United States)

    Chevallier, Patrice; Labopin, Myriam; Socie, Gerard; Rubio, Marie-There; Blaise, Didier; Vigouroux, Stephane; Huynh, Anne; Michallet, Mauricette; Bay, Jacques-Olivier; Maury, Sébastien; Yakoub-Agha, Ibrahim; Fegueux, Nathalie; Deconinck, Eric; Contentin, Nathalie; Maillard, Natacha; Bulabois, Claude-Eric; Francois, Sylvie; Oumedaly, Reman; Raus, Nicole; Mohty, Mohamad

    2015-05-01

    This retrospective study considered the outcomes of 181 patients with acute myeloid leukemia (AML) transplanted in second complete remission (CR2) between January 2005 and April 2012 and who received either a myeloablative autologous stem cell transplant (Auto-SCT; n = 82; median age: 48 years; median follow-up: 45 months) or an umbilical cord blood (UCB) allogeneic SCT (n = 99, median age: 46 years; median follow-up: 36 months; conditioning regimens: myeloablative n = 21, reduced n = 78; single unit n = 37, double units n = 62). Although the Auto group showed a significant better prognostic profile at transplant, with longer median interval between diagnosis and time of graft, higher incidence of good-risk cytogenetics and lower number of previously transplanted patients, 3-year OS and LFS were similar between both groups (Auto: 59 ± 6% vs. 50 ± 6%, P = 0.45; and 57 ± 6% vs. 46 ± 6%, P = 0.37). In multivariate analysis, UCB allo-SCT was associated with lower relapse incidence (HR: 0.3, 95% CI: 0.11-0.82, P = 0.02), but higher non-relapse mortality (NRM) (HR: 4.16; 95% CI: 1.46-11.9, P = 0.008). Results from this large study suggest that UCB allo-SCT provides better disease control than auto-SCT, which is especially important in the setting of high-risk disease. However, this disease control advantage is counterbalanced by higher toxicity, highlighting the need for novel approaches aiming to decrease NRM after UCB allo-SCT.

  3. Pareto utility

    NARCIS (Netherlands)

    Masako, I.; Laeven, R.J.A.; Magnus, J.R.; Muris, C.

    2013-01-01

    In searching for an appropriate utility function in the expected utility framework, we formulate four properties that we want the utility function to satisfy. We conduct a search for such a function, and we identify Pareto utility as a function satisfying all four desired properties. Pareto utility

  4. The Prospective Oral Mucositis Audit: relationship of severe oral mucositis with clinical and medical resource use outcomes in patients receiving high-dose melphalan or BEAM-conditioning chemotherapy and autologous SCT.

    NARCIS (Netherlands)

    McCann, S.; Schwenkglenks, M.; Bacon, P.; Einsele, H.; D'Addio, A.; Maertens, J.; Niederwieser, D.; Rabitsch, W.; Roosaar, A.; Ruutu, T.; Schouten, H.; Stone, R.; Vorkurka, S.; Quinn, B.; Blijlevens, N.M.A.

    2009-01-01

    The Prospective Oral Mucositis Audit was an observational study in 197 patients with multiple myeloma (MM) or non-Hodgkin's lymphoma (NHL) undergoing, respectively, high-dose melphalan or BEAM chemotherapy and autologous SCT at 25 European centres. We evaluated the relationship between severe oral m

  5. The Application of the SCT and the ANP Model to Refine the Most Critical ICT Determinants in Minimizing the Digital Divide

    Directory of Open Access Journals (Sweden)

    Ming-Yuan Hsieh

    2014-01-01

    Full Text Available This research cross-employed the social cognition theory (SCT and the analytical network process (ANP model in qualitative analyses and the multiple criteria decision making (MCDM methodology in quantitative measurements to comprehensively re-identify the most critical information communication technology (ICT determinants in minimizing the digital divide (DD. After measuring the complete importance of related priority weight w (eigenvector from the survey results given to various experts, the complete synthetically comparative index numbers (SCIN from the evaluation model used conveyed two distinct consequences. First, the highest SCIN scores for the ANP, F-ANP, and G-ANP models are 0.5516, 0.3771, and 0.4791, respectively, and are located in the “ICT can positively minimize the level of DD” (ICTCPMDD column in the summarized results table. Secondly, the highest evaluated weighted score of assessed criteria of 0.5801 is located in the Diversified Mobile Applications (DMAPP column. From these results, there are two contributive findings that can be deduced. First, ICT indeed proved the determinative influences and interplays in the level of DD which means that the undeveloped, developing, and emerging regions are apparently able to minimize the level of DD by means of the ICT development. Second, the Diversified Mobile Applications (DMAPP is the most critical determinant of ICT in minimizing the level of digital divide.

  6. Clinical significance of pretransplant serum ferritin on the outcome of allogeneic hematopoietic SCT: a prospective cohort study by the Kanto Study Group for Cell Therapy.

    Science.gov (United States)

    Tanaka, M; Kanamori, H; Matsumoto, K; Tachibana, T; Numata, A; Ohashi, K; Kobayashi, T; Nakaseko, C; Kanda, Y; Yamazaki, E; Fujisawa, S; Ooi, J; Sakura, T; Aotsuka, N; Onoda, M; Machida, S; Kato, J; Usuki, K; Watanabe, R; Taguchi, J; Yano, S; Saito, T; Takahashi, S; Sakamaki, H; Okamoto, S

    2015-05-01

    This prospective study aimed to investigate the influence of pretransplant serum ferritin levels on the outcomes of allogeneic hematopoietic SCT (HSCT). In total, 190 patients with acute leukemia or myelodysplastic syndrome were consecutively enrolled. The patients were divided into two groups: low-ferritin group (ferritin group (⩾1000 ng/mL). The primary end point was the cumulative incidence of infection within 100 days after HSCT, which was similar between the two groups: bloodstream infection, 35 vs 38%, P=0.65; bacterial infection, 44 vs 41%, P=0.68; and fungal infection, 6 vs 8%, P=0.71. The 1-year adjusted probability of OS of the high-ferritin group was significantly lower than that of the low-ferritin group (76 vs 63%, P=0.017). Using receiver operating characteristic curve, the threshold of pretransplant serum ferritin levels for bloodstream infection was 1400 ng/mL; the threshold for OS, EFS and non-relapse mortality was 1349 ng/mL. In conclusion, pretransplant serum ferritin levels of ⩾1000 ng/mL did not influence the incidence of infection but adversely affected OS after HSCT. A higher threshold of pretransplant serum ferritin levels may predict HSCT outcomes.

  7. PENGARUH LINGKUNGAN KERJA DAN STANDAR OPERASIONAL PROSEDUR TERHADAP PRODUKTIVITAS KERJA KARYAWAN PENGAWAS URUSAN GERBONG SUKACINTA(PUG SCT PT. KERETA API INDONESIA (PERSERO KABUPATEN LAHAT

    Directory of Open Access Journals (Sweden)

    Yayan Darmayanti

    2017-03-01

    Full Text Available Penelitian ini bertujuan untuk mengetahui pengaruh lingkungan kerja terhadap produktivitasi, pengaruh standar operasional prosedur terhadap terhadap produktivitas pada pengawas urusan gerbongsukacinta(PUG SCT PT. Kereta Api Indonesia (Persero Kabupaten Lahat. Metode penelitian dalam penelitian ini adalah analisis kuantitatif, Deskriptif, Uji Instrumen (validitas dan reliabilitas, Asumsi Klasik dan Analisis Statistik Intrensial (Uji Kesesuaian Model/Regresi Berganda, Koefisien determinasi, koefisien korelasi, uji T dan Uji F.Dan analisis Kualitatif yang memberikan penjelasan yang berhubungan dengan permasalahan yang didasarkan pada teori-teori manajemen Sumber Daya Manusia. Dari hasil perhitungan analisa regresi berganda pada penelitian ini didapat nilai persamaan : Y = 1.715 + 0.854 X1+ 0.135 X2 berarti bahwa lingkungan kerja dan standar operasional prosedur berpengaruh positif dalam produktivitas, besarnya koefisien determinasi (KD = 84,3% dipengaruhi oleh lingkungan kerja dan standar operasional prosedur dan sisa nya 15,7 % dipengaruhi oleh faktor lain yang tidak dibahas dalam penelitian ini, hasil dari perhitungan analisa koefisien korelasi didapat nilai r sebesar 0.921 (mendekati 1, artinya lingkungan kerja dan standar operasional prosedur mempunyai pengaruh yang positif dan sangat kuat terhadap produktivitas, hasil pengujian uji Tmenerangkan bahwa variabel X1 (lingkungan kerja dan X2 (standar operasional prosedur mempunyai pengaruh parsial terhadap variabel Y (produktivitas, dan uji F didapat nilai p-valuenya sebesar 0,000 lebih kecil dari nilai alpha yaitu 0,05 maka variabel lingkungan kerja dan standar operasional prosedur secara simultan berpengaruh terhadap produktivitas karyawan.sehingga hipotesis ini terbukti.

  8. LOOKING FOR A CONNECTION BETWEEN THE Am PHENOMENON AND HYBRID {delta} Sct -{gamma} Dor PULSATION: DETERMINATION OF THE FUNDAMENTAL PARAMETERS AND ABUNDANCES OF HD 114839 AND BD +18 4914

    Energy Technology Data Exchange (ETDEWEB)

    Hareter, M.; Weiss, W. [Department of Astronomy, University of Vienna, Tuerkenschanzstrasse 17, A-1180 Wien (Austria); Fossati, L. [Department of Physics and Astronomy, Open University, Walton Hall, Milton Keynes MK6 7AA (United Kingdom); Suarez, J. C. [Instituto de Astrofisica de Andalucia (CSIC), Glorieta de la Astronomia S/N, 18008, Granada (Spain); Uytterhoeven, K. [Kiepenheuer-Institut fuer Sonnenphysik, Schoeneckstr. 6, D-79104 Freiburg (Germany); Rainer, M.; Poretti, E., E-mail: hareter@astro.univie.ac.at [INAF-Osservatorio Astronomico di Brera, Via E. Bianchi 46, 23807, Merate (Saint Lucia) (Italy)

    2011-12-20

    {delta} Sct-{gamma} Dor hybrids pulsate simultaneously in p- and g-modes, which carry information on the structure of the envelope as well as to the core. Hence, they are key objects for investigating A and F type stars with asteroseismic techniques. An important requirement for seismic modeling is small errors in temperature, gravity, and chemical composition. Furthermore, we want to investigate the existence of an abundance indicator typical for hybrids, something that is well established for the roAp stars. Previous to the present investigation, the abundance pattern of only one hybrid and another hybrid candidate has been published. We obtained high-resolution spectra of HD 114839 and BD +18 4914 using the SOPHIE spectrograph of the Observatoire de Haute-Provence and the HARPS spectrograph at ESO La Silla. For each star we determined fundamental parameters and photospheric abundances of 16 chemical elements by comparing synthetic spectra with the observations. We compare our results to that of seven {delta} Sct and nine {gamma} Dor stars. For the evolved BD +18 4914 we found an abundance pattern typical for an Am star, but could not confirm this peculiarity for the less evolved star HD 114839, which is classified in the literature as uncertain Am star. Our result supports the concept of evolved Am stars being unstable. With our investigation we nearly doubled the number of spectroscopically analyzed {delta} Sct-{gamma} Dor hybrid stars, but did not yet succeed in identifying a spectroscopic signature for this group of pulsating stars. A statistically significant spectroscopic investigation of {delta} Sct- {gamma} Dor hybrid stars is still missing, but would be rewarding considering the asteroseismological potential of this group.

  9. Impact of cytogenetics risk on outcome after reduced intensity conditioning allo-SCT from an HLA-identical sibling for patients with AML in first CR: a report from the acute leukemia working party of EBMT.

    Science.gov (United States)

    Chevallier, P; Labopin, M; Milpied, N; Cornelissen, J J; Blaise, D; Petersen, E; Sandstedt, A; Goker, H; Socie, G; Rocha, V; Mohty, M

    2012-11-01

    So far the impact of cytogenetics risk on outcome in the context of reduced intensity conditioning (RIC) allo-SCT has been poorly studied. We have identified 378 AML patients in first CR who underwent RIC allo-SCT from an HLA-matched sibling donor between 2000 and 2007 reported to the European Group for Bone and Marrow Transplantation and for whom detailed cytogenetics data were available (good risk: n=21; intermediate risk: n=304; and poor risk: n=53). With a median follow-up of 24 months (range: 1-93), 2-year non-relapse mortality, relapse rate (RR), leukemia-free survival (LFS) and OS were 14%, 31%, 55% and 61%, respectively. Cytogenetics was significantly associated with RR (good risk: 10%; intermediate risk: 28%; and poor risk: 55% at 2 years, Pcytogenetics group (P=0.001, P=0.004) and in patients with a higher WBC at diagnosis (>10 × 10(9)/L) (Pcytogenetics had increased RR and decreased LFS after RIC allo-SCT, requiring new prospective strategies to improve results in this subgroup.

  10. Burr Utility

    NARCIS (Netherlands)

    Ikefuji, M.; Laeven, R.J.A.; Magnus, J.R.; Muris, C.H.M.

    2010-01-01

    This note proposes the Burr utility function. Burr utility is a flexible two-parameter family that behaves approximately power-like (CRRA) remote from the origin, while exhibiting exponential-like (CARA) features near the origin. It thus avoids the extreme behavior of the power family near the origi

  11. Estimating Utility

    DEFF Research Database (Denmark)

    Arndt, Channing; Simler, Kenneth R.

    2010-01-01

    an information-theoretic approach to estimating cost-of-basic-needs (CBN) poverty lines that are utility consistent. Applications to date illustrate that utility-consistent poverty measurements derived from the proposed approach and those derived from current CBN best practices often differ substantially......, with the current approach tending to systematically overestimate (underestimate) poverty in urban (rural) zones....

  12. The conundrum of HLA-DRB1*14:01/*14:54 and HLA-DRB3*02:01/*02:02 mismatches in unrelated hematopoietic SCT.

    Science.gov (United States)

    Pasi, A; Crocchiolo, R; Bontempelli, M; Carcassi, C; Carella, G; Crespiatico, L; Garbarino, L; Mascaretti, L; Mazzi, B; Mazzola, G; Miotti, V; Porfirio, B; Tagliaferri, C; Valentini, T; Vecchiato, C; Fleischhauer, K; Sacchi, N; Bosi, A; Martinetti, M

    2011-07-01

    Uncertainty still exists on the role of polymorphisms outside the HLA-DRB1 binding site or inside the HLA-DRB3 binding groove in unrelated hematopoietic SCT (HSCT). The ideal model to solve the conundrum consists of the transplants mismatched for HLA-DRB1*14:01/*14:54 and/or for HLA-DRB3*02:01/*02:02. A task force was set up in Italy to recruit transplanted pairs defined as HLA-DRB1*14:01 before 2006, the year crucial for the proper definition of the HLA-DRB1*14:54 allele in molecular biology. Out of 2723 unrelated pairs, 189 transplanted in Italy from 1995 to 2006 were HLA-DRB1*14:01 positive; 103/189 pairs with good historical DNA were retyped for HLA-DRB1*14 and HLA-DRB3 at-high resolution level; 31/103 pairs had HLA-DRB1*14 and/or HLA-DRB3 mismatched; 99/103, having complete clinical data, underwent statistical analysis for OS, TRM, disease-free survival and acute and chronic GvHD. No significant involvement of HLA-DRB1*14:01/*14:54 or HLA-DRB3*02:01/*02:02 mismatches was found, either alone or combined. Our findings suggest that disparities at exon 3 of the HLA-DRB1 gene seem unlikely to influence the outcome after HSCT. The same may be envisaged for HLA-DRB3(*)02:01 and (*)02:02 alleles which, although differing in the Ag binding site, seem unable to modulate an appreciable immune response in an HSCT setting.

  13. Multiattribute Utility Theory without Expected Utility Foundations

    NARCIS (Netherlands)

    A.M. Stiggelbout; P.P. Wakker

    1995-01-01

    Methods for determining the form of utilities are needed for the implementation of utility theory in specific decisions. An important step forward was achieved when utility theorists characterized useful parametric families of utilities, and simplifying decompositions of multiattribute utilities. Th

  14. Biochemical markers identify influences on bone and cartilage degradation in osteoarthritis - the effect of sex, Kellgren-Lawrence (KL score, Body Mass Index (BMI, oral salmon calcitonin (sCT treatment and diurnal variation

    Directory of Open Access Journals (Sweden)

    Henriksen K

    2010-06-01

    Full Text Available Abstract Background Osteoarthritis (OA involves changes in both bone and cartilage. These processes might be associated under some circumstances. This study investigated correlations between bone and cartilage degradation in patients with OA as a function of sex, Kellgren-Lawrence (KL score, Body Mass Index (BMI, oral salmon calcitonin (sCT treatment and diurnal variation. Methods This study was a 2-week, double-blind, double-dummy, randomized study including 37 postmenopausal women and 36 men, aged 57-75 years, with painful knee OA, and a KL-score of I - III. Subjects were allocated to one of three treatment arms: 0.6 mg or 0.8 mg oral sCT, or placebo given twice-daily for 14 days. Correlations between gender, KL score, or BMI and the bone resorption marker, serum C-terminal telopeptide of collagen type I (CTX-I, or the cartilage degradation marker, urine C-terminal telopeptide of collagen type II (CTX-II were investigated. Results At baseline, biomarkers indicated women with OA experienced higher bone and cartilage degradation than men. CTX-I levels were significantly higher, and CTX-II levels only marginally higher, in women than in men (p = 0.04 and p = 0.06, respectively. Increasing KL score was not correlated with bone resorption, but was significantly associated with the cartilage degradation CTX-II marker in both men and women (p = 0.007. BMI was significantly and negatively correlated to the bone resorption marker CTX-I, r = -0.40 (p = 0.002, but showed only a borderline positive correlation to CTX-II, r = 0.25 (p = 0.12. Before morning treatments on days 1 and 14, no correlation was seen between CTX-I and CTX-II in either the sCT or placebo group. However, oral sCT and food intake induced a clear correlation between these bone and cartilage degradation markers. Four hours after the first sCT dose on treatment days 1 and 14, a significant correlation (r = 0.71, p p = 0.02, but not on day 14. Conclusion Bone resorption was higher in

  15. SCT diagnosis and pathological analysis of hepatic angiomyolipoma%肝脏血管平滑肌脂肪瘤螺旋CT的诊断及病理基础

    Institute of Scientific and Technical Information of China (English)

    王镇; 华国铭; 夏从羊

    2011-01-01

    Objective To analyze the pathological characteristics and the variable appearances of hepatic angiomyolipomas on Spiral CT( SCT) and to improve the diagnostic accuracy with CT. Methods All cases were proved by surgical pathology. Spiral CT scanning of pre - and post - contrast arterial phase, portal venous phase and delay phase were performed in 10 cases. Results On CT pre - contrast scans, 9 of 10 lesions appeared as hypodense ,and the remaning one appeared as slightly hyperdense. On the arterial phase, all the lesions showed enhancement, and the central vascular could be seen in 7 lesions. On the portal venous phase and the delay phase, 8 lesions remained enhanced. Conclusion SCT could demonstrate the characterization of HAML, which is helpful in making a correct diagnosis preoperatively.%目的 分析10例肝脏血管平滑肌脂肪瘤(HAML)在螺旋CT( SCT)上的各种表现和病理特点,进一步提高CT对该病诊断的准确性.方法 所有病例均经手术病理证实,CT全肝平扫后行增强动脉期、门脉期和延迟期扫描.结果 CT平扫9个病灶为低密度,1个病灶为略高密度.动脉期所有病灶均强化,7个病灶可见中心血管影.门脉期及延迟期8个病灶持续强化.结论 SCT能显示HAML的某些特征,有助于术前诊断.

  16. Potent graft-versus-leukemia effect after reduced-intensity allogeneic SCT for intermediate-risk AML with FLT3-ITD or wild-type NPM1 and CEBPA without FLT3-ITD.

    Science.gov (United States)

    Labouré, Gaëlle; Dulucq, Stéphanie; Labopin, Myriam; Tabrizi, Reza; Guérin, Estelle; Pigneux, Arnaud; Lafarge, Xavier; Leguay, Thibaut; Bouabdallah, Krimo; Dilhuydy, Marie-Sarah; Duclos, Cédric; Lascaux, Axelle; Marit, Gérald; Mahon, François-Xavier; Boiron, Jean-Michel; Milpied, Noël; Vigouroux, Stéphane

    2012-12-01

    To investigate the role of reduced-intensity allogeneic (RIC-allo) stem cell transplant (SCT) as postremission therapy in adult intermediate-risk patients with acute myelogenous leukemia (AML) with FLT3-ITD or wild-type NPM1 and CEBPA without FLT3-ITD, we conducted a single-center retrospective study between January 2001 and December 2010. Sixty-six patients were included: 37 treated with RIC-alloSCT and 29 with nonallogeneic SCT therapies. Both groups were comparable concerning age, WBC count at diagnosis, gender, karyotype, genotype, and number of courses of chemotherapy to reach complete remission (CR1). Median follow-up after CR1 was 37 months (range, 11-112 months) and 48 months (range, 9-83 months) in the allo and no-allo groups, respectively. In the allo versus no-allo groups, the 3-year cumulative incidence of relapse (CIR) rates were 25% ± 8% versus 61% ± 9%; P = .005. The 3-year nonrelapse mortality (NRM), overall survival (OS), and relapse-free survival (RFS) were 22% ± 7% versus 4% ± 4% (P = .005), 52% ± 9% versus 44% ± 10% (P = .75), and 53% ± 9% versus 35% ± 9% (P = .28), respectively. Multivariate analysis indicated that CIR was reduced by allo (hazard ratio [HR], 0.32; P = .01). A landmark analysis performed at day 185 after CR1 confirmed a lower CIR after allo. RIC-allo reduces the risk of relapse, suggesting a potent graft-versus-leukemia (GVL) effect in these patients at a high risk of relapse.

  17. Haematopoietic cell transplantation with non-myeloablative conditioning in Denmark: disease-specific outcome, complications and hospitalization requirements of the first 100 transplants

    DEFF Research Database (Denmark)

    Kornblit, B.; Masmas, T.; Madsen, Helle Østergaard

    2008-01-01

    of immunosuppression was 37%. During the first and second year post transplant, patients experienced a mean of 41 and 13 outpatient clinic visits, and 53 and 16 days of hospitalization. Sixteen patients were admitted to the intensive care unit, of whom eight are still alive. In conclusion, transplantation outcomes...... were encouraging, but complications requiring admission and outpatient clinic visits occur frequently post transplant Udgivelsesdato: 2008/5...

  18. Anti-T-lymphocyte globulin-based non-myeloablative stem cell transplantation followed by HLA-identical donor lymphocyte infusion for hematologic malignancies

    Institute of Scientific and Technical Information of China (English)

    毛平; 王顺清; 王汉平; 李庆山; 许艳丽; 莫文健; 应逸; 朱志刚

    2003-01-01

    Objective To evaluate the application of anti-T-lymphocyte globulin (ATG) based nonmyeloablative but profoundly immunosuppressive regimens followed by donor lymphocyte infusion (DLI) for the treatment of hematologic malignancies.Methods The protocol was designed to minimize the intensity of the conditioning regimen to the range of nonmyeloablative therapies based on ATG with low-dose busulfan (Bu) and Cytoxan (CTX) (15-19.5 mg/kg, 8 mg/kg and 80 mg/kg, respectively). The patients received the first lymphocytic infusion from HLA-identical sibling donors on days 28-30 after transplant, and the first T cell dosage of 106/kg followed by the escalated dosage in the range of (0.5-1.5)×108/kg. The total number of procedures were performed at a median of 4.2 procedures (range of 2-8 procedures).Results Engraftment was documented in all six patients in the form of donor-recipient hematopoietic cells mixed chimera at early-stage posttransplant, which was converted gradually into complet chimera by DLI in four patients. Graft-versus-host disease (GVHD) developed in three of six cases, only one of which was severe. To date,four patients are disease free and alive.Conclusions Allogeneic donor stem cell engraftment into host can be achieved by nonmyeloablative conditioning regimen based on ATG. Transient mixed donor-recipient hematopoietic cell mixed with chimeras may be successfully converted into complete chimerism by DLI posttransplant. GVHD remains major clinical concern in our study.

  19. Non-myeloablative bone marrow transplant and platelet infusion can transiently improve the clinical outcome of mitochondrial neurogastrointestinal encephalopathy: a case report.

    Science.gov (United States)

    Hussein, Eiman

    2013-10-01

    Mitochondrial neurogastrointestinal encephalopathy (MNGIE) is caused by deficiency in thymidine phosphorylase (TP), that regulates thymidine (dThd) and deoxyuridine (dUrd). Toxic levels of dThd and dUrd can lead to mitochondrial dysfunction by impairing mitochondrial DNA replication, causing GI and neurologic deterioration. We studied the impact of bone marrow transplant (BMT) and platelets, as a source of TP on the clinical outcome of MNGIE. We report a case of MNGIE, who presented with severe vomiting. Over time, he was non-ambulatory and his GI symptoms got progressively worse with severe dysphagia, abdominal pain episodes, persistent vomiting and diarrhea. Being unfit for intense conditioning regimen, he received a mini BMT, with mild conditioning regimen. Bone marrow was obtained from his HLA fully matched brother. One month after transplantation, donor chimerism in peripheral blood was 33%. Excellent clinical responses were achieved 3 months after transplantation and circulating donor cell chimerism decreased to 24% with a significant increase in platelet TP activity. Ten months post transplant the patient's symptoms recurred and fresh single donor platelets were infused, with a significant increase in platelet TP activity. Mini BMT and platelet transfusion can transiently increase circulating TP activity and might prevent progress of this fatal disease. Copyright © 2013 Elsevier Ltd. All rights reserved.

  20. Haematopoietic cell transplantation with non-myeloablative conditioning in Denmark: disease-specific outcome, complications and hospitalization requirements of the first 100 transplants

    DEFF Research Database (Denmark)

    Kornblit, B.; Masmas, T.; Madsen, Helle Østergaard

    2008-01-01

    We analysed the outcome and hospitalization requirements of the first 100 patients (Hodgkin's disease (HD), N=13; multiple myeloma (MM), N=14; CLL, N=12; non-Hodgkin's lymphoma (NHL), N=17; myelodysplastic syndrome (MDS), N=18; AML, N=24 and CML, N=2) treated in Denmark with haematopoietic cell t...

  1. Multiattribute Utility Theory without Expected Utility Foundations

    NARCIS (Netherlands)

    J. Miyamoto (John); P.P. Wakker (Peter)

    1996-01-01

    textabstractMethods for determining the form of utilities are needed for the implementation of utility theory in specific decisions. An important step forward was achieved when utility theorists characterized useful parametric families of utilities and simplifying decompositions of multiattribute ut

  2. Analysis for the pathological characteristics and SCT of hepatic angiomyolipoma%肝脏血管平滑肌脂肪瘤的病理特点和螺旋CT分析

    Institute of Scientific and Technical Information of China (English)

    刘磊; 薛鹏

    2009-01-01

    目的 探讨肝脏血管平滑肌脂肪瘤(HAML)的螺旋CT(SCT)和病理特点,以减少对该病的误诊.方法 观察5例HAML的SCT表现,采用HE切片染色和免疫组化染色,并结合文献复习其临床及病理特点,诊断和鉴别诊断.结果 SCT平扫肝内边界欠清3例,界限清楚2例;肝右叶4例,左叶1例;增强检查动脉期5例均有强化表现,不均匀4例,较均匀1例.病理特点HE形态上肿瘤有梭形或上皮样的肌样细胞,脂肪组织和厚壁血管构成.免疫组化HMB45和MelanA明显阳性,S-100和SMA部分阳性.结论 HAML易与其它肝病误诊,术前仔细分析其SCT表现,必要时CT引导下穿刺活检、HE形态及免疫组化染色可明确诊断.

  3. BK Virus-Hemorrhagic Cystitis Following Allogeneic Stem Cell Transplantation: Clinical Characteristics and Utility of Leflunomide Treatment

    Directory of Open Access Journals (Sweden)

    Young Hoon Park

    2016-08-01

    Full Text Available Objective: BK virus-hemorrhagic cystitis (BKV-HC is a potential cause of morbidity and mortality in patients having undergone allogeneic stem cell transplantation (Allo-SCT. We analyzed the clinical features of BKV-HC following Allo-SCT and reported the utility of leflunomide therapy for BKV-HC. Materials and methods: From January 2005 to June 2014, among the 69 patients underwent Allo-SCT in our institution, the patients who experienced BKV-HC were investigated retrospectively. Results: Hemorrhagic cystitis (HC was observed in 30 patients (43.5%, and among them, 18 patients (26.1% were identified as BKV-HC. The median age of the patients (12 males and 6 females was 45 years (range, 13-63. Patients received Allo-SCT from acute myeloid leukemia (n=11, aplastic anemia (n=4, myelodysplastic syndrome (n=2, and non-Hodgkin lymphoma (n=1.The donor types were a HLA-matched sibling donor for 6 patients, HLA-matched unrelated donor for 9, and a haploidentical familial donor for 2. The median onset and duration of BKV-HC was on day 21 (range, 7-97 after transplantation and 22 days (range, 6-107. Eleven patients (62.1% had grade I-II HC and seven patients (38.9% had grade III-IV (high-grade HC. Among the seven patients who had high-grade HC, one had complete response (CR, one partial response (PR, and five no response (NR. Among the five non-responders, one died of BKV-HC associated complications. The remaining four patients were treated with leflunomide, with achieving CR (n=2 and PR (n=2. The median duration from the start of leflunomide therapy to response was 13 days (range, 8–17 days. All patients tolerated the leflunomide treatment well, with three patients having mild gastrointestinal symptoms, including anorexia and abdominal bloating. Conclusion: BKV-HC was commonly observed in patients with HC following Allo-SCT. In high-grade BKV-HC patients who fail supportive care, leflunomide may be a feasible option without significant toxicity. Materials

  4. Utility usage forecasting

    Energy Technology Data Exchange (ETDEWEB)

    Hosking, Jonathan R. M.; Natarajan, Ramesh

    2017-08-22

    The computer creates a utility demand forecast model for weather parameters by receiving a plurality of utility parameter values, wherein each received utility parameter value corresponds to a weather parameter value. Determining that a range of weather parameter values lacks a sufficient amount of corresponding received utility parameter values. Determining one or more utility parameter values that corresponds to the range of weather parameter values. Creating a model which correlates the received and the determined utility parameter values with the corresponding weather parameters values.

  5. Entrez Programming Utilities

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Entrez Programming Utilities (E-utilities) are a set of eight server-side programs that provide a stable interface into the Entrez query and database system at...

  6. Nonexpected utility and coherence

    NARCIS (Netherlands)

    Diecidue, E.

    2001-01-01

    The descriptive power of expected utility has been challenged by behavioral evidence showing that people deviate systematically from the expected utility paradigm. Since the end of the 70's several alternatives to the classical expected utility paradigm have been proposed in order to accommodate the

  7. Information, evolution and utility

    Directory of Open Access Journals (Sweden)

    Larry Samuelson

    2006-03-01

    Full Text Available Human utility embodies a number of seemingly irrational aspects. The leading example in this paper is that utilities often depend on the presence of salient unchosen alternatives. Our focus is to understand why an evolutionary process might optimally lead to such seemingly dysfunctional features in our motivations and to derive implications for the nature of our utility functions.

  8. A Study on SMV and SMA with SCT and its Clinical Significance%螺旋CT对肠系膜上动静脉的研究及临床意义

    Institute of Scientific and Technical Information of China (English)

    赵小虎; 郑少强; 李恩美; 吴元佐

    2001-01-01

    目的准确认识肠系膜上动脉(superior mesenter ic artery ,SMA)、肠系膜上静脉(superior mesenteric vein ,SMV) 横断面解剖,及其与胰腺钩突、十二指肠水平部解剖关系.方法对行上腹部螺旋CT( spiral CT,SCT) 动脉期及门脉期双期扫描的100例正常成人,在门脉期图像上,先确定呈苹果状突起的肠系膜上动脉与腹主动脉交界平面作为定位平面,以其下方1~2 cm作为测量与分析平面,对SMA、SMV横断位大小、形态、位置及有关间距加以测量分析,并对胰腺钩突及十二指肠与它们的关系进行了观察.结果 SMA、SMV多均呈管壁光滑的圆形(83%),只有少部分 SMV呈椭圆形(17%).管径SMV绝大多数大于SMA(95%),少数相等,未见一例相反.两者关系方面,绝大多数(94%)SMV位于SMA之右侧,少数情况下两者呈前后平行关系(6%).SMV偏前者(51%),SMA偏前者(24%),两者左右并行(19% ).两者中心间距平均 15.31 mm左右.SMV 与正中矢线距离平均18.09 mm左右.,SMV、SM A距椎体前缘水平线之垂直距离平均41.30、40.10 mm.而胰腺钩突全部位于SMV与下腔静脉之间.20例胰腺病变者,主要表现为血管周围脂肪模糊不清,血管受压、变形、推移及包绕破坏.结论 SCT增强检查可清楚显示SMV、SMA及其与周围脏器的关系,对胰腺钩突的定位及胰腺病变的诊断有重要意义.

  9. Measurement of the $B_{s} \\to K^{+}K^{-}$ lifetime and extraction of the $\\Delta\\Gamma_{CP}/\\Gamma_{CP}$ at CDF Run II and Development of the ATLAS-SCT endcap modules

    Energy Technology Data Exchange (ETDEWEB)

    Donega, Mauro [Univ. of Geneva (Switzerland)

    2006-01-01

    In the first part of the present work we present the first measurement of the Bd and Bs meson lifetimes in charmless decays (Bd → K+π-, Bd → π+π-, Bs → K+K-) based on 360pb-1 of p$\\bar{p}$ collision taken at the CDF Run II detector and the extraction $\\frac{ΔΓCP}{ΓCP}$ for the Bs-meson. We find the Bd-meson lifetime (in the Bd → K+π- and Bd → π+π- decay modes) to be: cτ (Bd) = 452 ± 24 (stat) ± 6 (syst) µm τ (Bd) = 1.51 ± 0.08 (stat) ± 0.02 (syst) ps and the Bs-meson lifetime (in the Bs → K+K- decay mode) to be: cτ (Bs → K+K-) = 458 ± 53 (stat) ± 6 (syst) µm τ (Bs → K+K-) = 1.53 ± 0.18 (stat) ± 0.02 (syst) ps Both measurements are consistent with the world averages. We calculate the ΔΓCP CP for the Bs meson combining the measured lifetime in the Bs → K+K- decay with the world average value of the Bs-meson lifetime in the flavour specific decays: We find: cτfs = 441 ± 13 µm τfs = 1.472 ± 0.045 ps ΔΓCP /ΓCP = -0.08 ± 0.23 (stat.) ± 0.03 (syst.) that is compatible with the theoretical expectation of (7.2 ± 2.4) × 10-2. In the second part of the present work, a few steps of the final R&D of the ATLAS-SCT endcaps modules will be reported. Two module layouts have been developed on two different electrical hybrids de- signs. Both layouts have been produced in small prototype series and tested before and after exposing them to a particle fluence equivalent to that expected at the end of the ATLAS data taking.

  10. Study on information utility

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Information has two aspects. One aspect is the objective one; another aspect is the subjective one. Shannon has discussed the objective aspect of information in information theory. But the subjective aspect of information has not been fully discussed. Someone use "Bayesian approaches" to evaluate the value of information. But in some cases it does not meet the information user's need. This paper is focus on the subjective aspect of objectively measurable information and gives formal definitions for information, information utility, and marginal information utility, normalized calculation of information utility. The information discussed in the paper has interdisciplinary nature. This work can be the foundation of many application areas.

  11. Information, Utility & Bounded Rationality

    CERN Document Server

    Ortega, Pedro A

    2011-01-01

    Perfectly rational decision-makers maximize expected utility, but crucially ignore the resource costs incurred when determining optimal actions. Here we employ an axiomatic framework for bounded rational decision-making based on a thermodynamic interpretation of resource costs as information costs. This leads to a variational "free utility" principle akin to thermodynamical free energy that trades off utility and information costs. We show that bounded optimal control solutions can be derived from this variational principle, which leads in general to stochastic policies. Furthermore, we show that risk-sensitive and robust (minimax) control schemes fall out naturally from this framework if the environment is considered as a bounded rational and perfectly rational opponent, respectively. When resource costs are ignored, the maximum expected utility principle is recovered.

  12. Chemical Search Web Utility

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Chemical Search Web Utility is an intuitive web application that allows the public to easily find the chemical that they are interested in using, and which...

  13. Utilization of lignin

    Energy Technology Data Exchange (ETDEWEB)

    Machihara, A.

    1981-01-01

    The chemical structure of lignin, the composition of pulping spent liquors, conversion of lignin into fine chemicals, utilization of lignin products, and physical and chemical properties of lignin and and derivatives are reviewed. (Refs 29).

  14. UtilityOther_ELCFRANCHISE

    Data.gov (United States)

    Vermont Center for Geographic Information — ELCFRANCHISE includes Vermont's Electric Utility Franchise boundaries. It is a compilation of many data sources. The boundaries are approximate and should be used...

  15. UtilityTelecom_TELEFAC

    Data.gov (United States)

    Vermont Center for Geographic Information — The UtilityTelecom_TELEFAC data layer contains points which are intended to represent the location of telecommunications facilities (towers and/or antennas) in...

  16. Biotechnology of space utilization

    Energy Technology Data Exchange (ETDEWEB)

    Matsumiya, Hiroyuki

    1989-10-05

    This paper introdued the practical results of biotechnological experiments utilizing features of space and the present Japanese plan. The electrophoresis and crystal growth of protein utilize the microgravity field and cell culture utilizes the influence of microgravity on organism. Of practical results in space experiments, the electrophoresis was made by US but others were carried out by Europian countries. It was thought that the electrophoresis utilizing space environment could be demonstrated to be promosing for the separating and refining techniques by the experiment on the basis of the Apolo Project. The crystal growth of protein was reported by Litke of Denmark as to the crystal of lyzozyme. The space experiment of cell culture was carried out by Cogoli of Switzerland as to the culture of lymphocyte in the Shattle. Japan is studying the primary material experiment project(FMPT) in the Space Shattle and unmanned experiment for electrophoresis. 9 refs., 3 tabs.

  17. MSIS Drug Utilization Datamart

    Data.gov (United States)

    U.S. Department of Health & Human Services — This page provides background needed to take advantage of the capabilities of the MSIS Drug Utilization Datamart. This mart allows the user to develop high-level...

  18. Utility requirements for fusion

    Energy Technology Data Exchange (ETDEWEB)

    Vondrasek, R.J.

    1982-02-01

    This report describes work done and results obtained during performance of Task 1 of a study of Utility Requirements and Criteria for Fusion Options. The work consisted of developing a list of utility requirements for fusion optics containing definition of the requirements and showing their relative importance to the utility industry. The project team members developed a preliminary list which was refined by discussions and literature searches. The refined list was recast as a questionnaire which was sent to a substantial portion of the utility industry in this country. Forty-three questionnaire recipients responded including thirty-two utilities. A workshop was held to develop a revised requirements list using the survey responses as a major input. The list prepared by the workshop was further refined by a panel consisting of vice presidents of the three project team firms. The results of the study indicate that in addition to considering the cost of energy for a power plant, utilities consider twenty-three other requirements. Four of the requirements were judged to be vital to plant acceptability: Plant Capital Cost, Financial Liability, Plant Safety and Licensability.

  19. Health care utilization

    DEFF Research Database (Denmark)

    Jacobsen, Christian Bøtcher; Andersen, Lotte Bøgh; Serritzlew, Søren

    An important task in governing health services is to control costs. The literatures on both costcontainment and supplier induced demand focus on the effects of economic incentives on health care costs, but insights from these literatures have never been integrated. This paper asks how economic cost...... make health professionals provide more of this service to each patient, but that lower user payment (unexpectedly) does not necessarily mean higher total cost or a stronger association between the number of patients per supplier and the health care utilization. This implies that incentives...... are important, but that economics cannot alone explain the differences in health care utilization....

  20. Module utilization committee

    Science.gov (United States)

    Volkmer, K.; Praver, G.

    1984-01-01

    Photovoltaic collector modules were declared surplus to the needs of the U.S. Dept. of Energy. The Module Utilization Committee was formed to make appropriate disposition of the surplus modules on a national basis and to act as a broker for requests for these modules originating outside of the National Photovoltaics Program.

  1. Male Adolescent Contraceptive Utilization.

    Science.gov (United States)

    Finkel, Madelon Lubin; Finkel, David J.

    1978-01-01

    The contraceptive utilization of a sample of sexually active, urban, high school males (Black, Hispanic, and White) was examined by anonymous questionnaire. Contraceptive use was haphazard, but White males tended to be more effective contraceptors than the other two groups. Reasons for nonuse were also studied. (Author/SJL)

  2. Electric utilities in Illinois

    Energy Technology Data Exchange (ETDEWEB)

    1978-01-01

    Although the conference dealt specifically with concerns of the electric utilities in Illinois, the issues were dealt with in the national context as well. A separate abstract was prepared for each of the 5 sections of this proceeding. A total of 25 papers were presented. Section titles are: Forecasting, Planning and Siting, Reliability, Rates and Financing, and Future Developments.

  3. Allogeneic transplantation following non-myeloablative conditioning in renal carcinoma. New evidence of the immune mechanisms responsible for the activity of this form of immunotherapy and the pathogenetic role of endogenous retroviruses

    Directory of Open Access Journals (Sweden)

    Camillo Porta

    2011-12-01

    Full Text Available In 2000, the influential New England Journal of Medicine published the first impressive results of the use of allogeneic stem cell transplantation following nonmyeloblative conditioning (the so-called ‘mini-allo transplant’ in the treatment of patients with advanced kidney cancer...

  4. Utilities:Other:Utilities at Pipe Spring National Monument, Arizona (Utilities.gdb:Other:utilpnt_other)

    Data.gov (United States)

    National Park Service, Department of the Interior — This feature class represents various types of utilities, not including water- and power-related utilities, at Pipe Spring National Monument, Arizona. The utilities...

  5. Industrial coal utilization

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-01-01

    The effects of the National Energy Act on the use of coal in US industrial and utility power plants are considered. Innovative methods of using coal in an environmentally acceptable way are discussed: furnace types, fluidized-bed combustion, coal-oil-mixtures, coal firing in kilns and combustion of synthetic gas and liquid fuels. Fuel use in various industries is discussed with trends brought about by uncertain availability and price of natural gas and fuel oils: steel, chemical, cement, pulp and paper, glass and bricks. The symposium on Industrial Coal Utilization was sponsored by the US DOE, Pittsburgh Energy Technology Center, April 3 to 4, 1979. Twenty-one papers have been entered individually into the EDB. (LTN)

  6. Industrial coal utilization

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-01-01

    The effects of the National Energy Act on the use of coal in US industrial and utility power plants are considered. Innovative methods of using coal in an environmentally acceptable way are discussed: furnace types, fluidized-bed combustion, coal-oil-mixtures, coal firing in kilns and combustion of synthetic gas and liquid fuels. Fuel use in various industries is discussed with trends brought about by uncertain availability and price of natural gas and fuel oils: steel, chemical, cement, pulp and paper, glass and bricks. The symposium on Industrial Coal Utilization was sponsored by the US DOE, Pittsburgh Energy Technology Center, April 3 to 4, 1979. Twenty-one papers have been entered individually into the EDB. (LTN)

  7. UTILITY OF SIMPLIFIED LABANOTATION

    OpenAIRE

    Maria del Pilar Naranjo

    2016-01-01

    After using simplified Labanotation as a didactic tool for some years, the author can conclude that it accomplishes at least three main functions: efficiency of rehearsing time, social recognition and broadening of the choreographic consciousness of the dancer. The doubts of the dancing community about the issue of ‘to write or not to write’ are highly determined by the contexts and their own choreographic evolution, but the utility of Labanotation, as a tool for knowledge, is undeniable.

  8. Windpower utilization possibilities

    Science.gov (United States)

    Hoetzel, C.

    1982-01-01

    The possibilities of windpower utilization for mechanical pumps, electric generators, mechanical water vortex pumps, and heat pumps are reviewed. Application possibilities can be realized by windpower systems of different size. It must however be determined for which purpose and for which power range they are used. The site and the concomitant wind potential is of utmost importance. Small units in the 10 kW power range are very interesting for autonomous or semiautonomous energy supply.

  9. UTILITY OF SIMPLIFIED LABANOTATION

    Directory of Open Access Journals (Sweden)

    Maria del Pilar Naranjo

    2016-02-01

    Full Text Available After using simplified Labanotation as a didactic tool for some years, the author can conclude that it accomplishes at least three main functions: efficiency of rehearsing time, social recognition and broadening of the choreographic consciousness of the dancer. The doubts of the dancing community about the issue of ‘to write or not to write’ are highly determined by the contexts and their own choreographic evolution, but the utility of Labanotation, as a tool for knowledge, is undeniable.

  10. Time functions as utilities

    CERN Document Server

    Minguzzi, E

    2009-01-01

    Every time function on spacetime gives a (continuous) total preordering of the spacetime events which respects the notion of causal precedence. The problem of the existence of a (semi-)time function on spacetime and the problem of recovering the causal structure starting from the set of time functions are studied. It is pointed out that these problems have an analog in the field of microeconomics known as utility theory. In a chronological spacetime the semi-time functions correspond to the utilities for the chronological relation, while in a K-causal (stably causal) spacetime the time functions correspond to the utilities for the K^+ relation (Seifert's relation). By exploiting this analogy, we are able to import some mathematical results, most notably Peleg's and Levin's theorems, to the spacetime framework. As a consequence, we prove that a K-causal (i.e. stably causal) spacetime admits a time function and that the time or temporal functions can be used to recover the K^+ (or Seifert) relation which indeed...

  11. Time Functions as Utilities

    Science.gov (United States)

    Minguzzi, E.

    2010-09-01

    Every time function on spacetime gives a (continuous) total preordering of the spacetime events which respects the notion of causal precedence. The problem of the existence of a (semi-)time function on spacetime and the problem of recovering the causal structure starting from the set of time functions are studied. It is pointed out that these problems have an analog in the field of microeconomics known as utility theory. In a chronological spacetime the semi-time functions correspond to the utilities for the chronological relation, while in a K-causal (stably causal) spacetime the time functions correspond to the utilities for the K + relation (Seifert’s relation). By exploiting this analogy, we are able to import some mathematical results, most notably Peleg’s and Levin’s theorems, to the spacetime framework. As a consequence, we prove that a K-causal (i.e. stably causal) spacetime admits a time function and that the time or temporal functions can be used to recover the K + (or Seifert) relation which indeed turns out to be the intersection of the time or temporal orderings. This result tells us in which circumstances it is possible to recover the chronological or causal relation starting from the set of time or temporal functions allowed by the spacetime. Moreover, it is proved that a chronological spacetime in which the closure of the causal relation is transitive (for instance a reflective spacetime) admits a semi-time function. Along the way a new proof avoiding smoothing techniques is given that the existence of a time function implies stable causality, and a new short proof of the equivalence between K-causality and stable causality is given which takes advantage of Levin’s theorem and smoothing techniques.

  12. Tribal Utility Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Engel, R. A.; Zoellick, J. J.

    2007-06-30

    The Schatz Energy Research Center (SERC) assisted the Yurok Tribe in investigating the feasibility of creating a permanent energy services program for the Tribe. The original purpose of the DOE grant that funded this project was to determine the feasibility of creating a full-blown Yurok Tribal electric utility to buy and sell electric power and own and maintain all electric power infrastructure on the Reservation. The original project consultant found this opportunity to be infeasible for the Tribe. When SERC took over as project consultant, we took a different approach. We explored opportunities for the Tribe to develop its own renewable energy resources for use on the Reservation and/or off-Reservation sales as a means of generating revenue for the Tribe. We also looked at ways the Tribe can provide energy services to its members and how to fund such efforts. We identified opportunities for the development of renewable energy resources and energy services on the Yurok Reservation that fall into five basic categories: • Demand-side management – This refers to efforts to reduce energy use through energy efficiency and conservation measures. • Off-grid, facility and household scale renewable energy systems – These systems can provide electricity to individual homes and Tribal facilities in areas of the Reservation that do not currently have access to the electric utility grid. • Village scale, micro-grid renewable energy systems - These are larger scale systems that can provide electricity to interconnected groups of homes and Tribal facilities in areas of the Reservation that do not have access to the conventional electric grid. This will require the development of miniature electric grids to serve these interconnected facilities. • Medium to large scale renewable energy development for sale to the grid – In areas where viable renewable energy resources exist and there is access to the conventional electric utility grid, these resources can be

  13. Social group utility maximization

    CERN Document Server

    Gong, Xiaowen; Yang, Lei; Zhang, Junshan

    2014-01-01

    This SpringerBrief explains how to leverage mobile users' social relationships to improve the interactions of mobile devices in mobile networks. It develops a social group utility maximization (SGUM) framework that captures diverse social ties of mobile users and diverse physical coupling of mobile devices. Key topics include random access control, power control, spectrum access, and location privacy.This brief also investigates SGUM-based power control game and random access control game, for which it establishes the socially-aware Nash equilibrium (SNE). It then examines the critical SGUM-b

  14. MUNI-FITS-Utils

    Science.gov (United States)

    Chrastina, M.; Zejda, M.; Mikulášek, Z.

    2010-12-01

    The FITS standard allows arbitrary use of name-space for keywords, except some reserved keywords. Result of this freedom is that several keywords have the same meaning. Similar problem is that values of keywords have different physical units. These facts complicate automated data processing and also creation of FITS file archives with simple structure. MUNI-FITS-Utils is a package of Python scripts which have been developed in PyFITS, a Python FITS Module. Scripts are user-friendly and allow manipulating FITS headers to get uniform shape. Further functions will be added soon.

  15. Utilization of coalbed methane

    Energy Technology Data Exchange (ETDEWEB)

    Gustavson, J.B. [Gustavson Associates Inc., Boulder, CO (United States)

    1996-02-01

    Substantial progress has been made in capturing coalbed methane (CBM gas), which constitutes a valuable source of clean burning energy. It is of importance to study the various potential uses of coalbed methane and to understand the various technologies required, as well as their economics and any institutional constraints. In industrialised countries, the uses of coalbed methane are almost solely dependent on microeconomics; coalbed methane must compete for a market against natural gas and other energy sources - and frequently, coalbed methane is not competitive against other energy sources. In developing countries, on the other hand, particularly where other sources of energy are in short supply, coalbed methane economics yield positive results. Here, constraints to development of CBM utilization are mainly lack of technology and investment capital. Sociological aspects such as attitude and cultural habits, may also have a strong negative influence. This paper outlines the economics of coalbed methane utilization, particularly its competition with natural gas, and touches upon the many different uses to which coalbed methane may be applied. 24 refs., 4 figs.

  16. Geothermal Resource Utilization

    Energy Technology Data Exchange (ETDEWEB)

    Lienau, Paul J.

    1998-01-03

    Man has utilized the natural heat of the earth for centuries. Worldwide direct use of geothermal currently amounts to about 7,000 MWt, as compared to 1,500 MWe, now being used for the generation of electricity. Since the early 1970s, dwindling domestic reservoirs of oil and gas, continued price escalation of oil on the world market and environmental concerns associated with coal and nuclear energy have created a growing interest in the use of geothermal energy in the United States. The Department of Energy goals for hydrothermal resources utilization in the United States, expressed in barrels of oil equivalent, is 50 to 90 million bbl/yr by 1985 and 350 to 900 million bbl/yr by the year 2000. This relatively clean and highly versatile resource is now being used in a multitude of diverse applications (e.g., space heating and cooling, vegetable dehydration, agriculture, aquaculture, light manufacturing), and other applications requiring a reliable and economic source of heat.

  17. Asteroid exploration and utilization

    Science.gov (United States)

    Radovich, Brian M.; Carlson, Alan E.; Date, Medha D.; Duarte, Manny G.; Erian, Neil F.; Gafka, George K.; Kappler, Peter H.; Patano, Scott J.; Perez, Martin; Ponce, Edgar

    1992-01-01

    The Earth is nearing depletion of its natural resources at a time when human beings are rapidly expanding the frontiers of space. The resources possessed by asteroids have enormous potential for aiding and enhancing human space exploration as well as life on Earth. Project STONER (Systematic Transfer of Near Earth Resources) is based on mining an asteroid and transporting raw materials back to Earth. The asteroid explorer/sample return mission is designed in the context of both scenarios and is the first phase of a long range plan for humans to utilize asteroid resources. Project STONER is divided into two parts: asteroid selection and explorer spacecraft design. The spacecraft design team is responsible for the selection and integration of the subsystems: GNC, communications, automation, propulsion, power, structures, thermal systems, scientific instruments, and mechanisms used on the surface to retrieve and store asteroid regolith. The sample return mission scenario consists of eight primary phases that are critical to the mission.

  18. Hydrogen and energy utilities

    Energy Technology Data Exchange (ETDEWEB)

    Hustadt, Daniel [Vattenfall Europe Innovation GmbH (Germany)

    2010-07-01

    Renewable electricity generation plays one major role with the biggest share being wind energy. At the end of the year 2009 a wind power plant capacity of around 26 GW was installed in Germany. Several outlooks come to the conclusion that this capacity can be doubled in ten years (compare Figure 1). Additionally the German government has set a target of 26 GW installed off-shore capacity in North and Baltic Sea until 2030. At Vattenfall only a minor percentage of the electricity production comes from wind power today. This share will be increased up to 12% until 2030 following Vattenfall's strategy 'Making Electricity Clean'. This rapid development of wind power offers several opportunities but also means some challenges to Utilities. (orig.)

  19. Utility-Based HTN Planning

    NARCIS (Netherlands)

    Georgievski, Ilche; Lazovik, Alexander

    2014-01-01

    We propose the use of HTN planning for risk-sensitive planning domains. We suggest utility functions that reflect the risk attitude of compound tasks, and adapt a best-first search algorithm to take such utilities into account.

  20. YEAR 2 BIOMASS UTILIZATION

    Energy Technology Data Exchange (ETDEWEB)

    Christopher J. Zygarlicke

    2004-11-01

    This Energy & Environmental Research Center (EERC) Year 2 Biomass Utilization Final Technical Report summarizes multiple projects in biopower or bioenergy, transportation biofuels, and bioproducts. A prototype of a novel advanced power system, termed the high-temperature air furnace (HITAF), was tested for performance while converting biomass and coal blends to energy. Three biomass fuels--wood residue or hog fuel, corn stover, and switchgrass--and Wyoming subbituminous coal were acquired for combustion tests in the 3-million-Btu/hr system. Blend levels were 20% biomass--80% coal on a heat basis. Hog fuel was prepared for the upcoming combustion test by air-drying and processing through a hammer mill and screen. A K-Tron biomass feeder capable of operating in both gravimetric and volumetric modes was selected as the HITAF feed system. Two oxide dispersion-strengthened (ODS) alloys that would be used in the HITAF high-temperature heat exchanger were tested for slag corrosion rates. An alumina layer formed on one particular alloy, which was more corrosion-resistant than a chromia layer that formed on the other alloy. Research activities were completed in the development of an atmospheric pressure, fluidized-bed pyrolysis-type system called the controlled spontaneous reactor (CSR), which is used to process and condition biomass. Tree trimmings were physically and chemically altered by the CSR process, resulting in a fuel that was very suitable for feeding into a coal combustion or gasification system with little or no feed system modifications required. Experimental procedures were successful for producing hydrogen from biomass using the bacteria Thermotoga, a deep-ocean thermal vent organism. Analytical procedures for hydrogen were evaluated, a gas chromatography (GC) method was derived for measuring hydrogen yields, and adaptation culturing and protocols for mutagenesis were initiated to better develop strains that can use biomass cellulose. Fly ash derived from

  1. YEAR 2 BIOMASS UTILIZATION

    Energy Technology Data Exchange (ETDEWEB)

    Christopher J. Zygarlicke

    2004-11-01

    This Energy & Environmental Research Center (EERC) Year 2 Biomass Utilization Final Technical Report summarizes multiple projects in biopower or bioenergy, transportation biofuels, and bioproducts. A prototype of a novel advanced power system, termed the high-temperature air furnace (HITAF), was tested for performance while converting biomass and coal blends to energy. Three biomass fuels--wood residue or hog fuel, corn stover, and switchgrass--and Wyoming subbituminous coal were acquired for combustion tests in the 3-million-Btu/hr system. Blend levels were 20% biomass--80% coal on a heat basis. Hog fuel was prepared for the upcoming combustion test by air-drying and processing through a hammer mill and screen. A K-Tron biomass feeder capable of operating in both gravimetric and volumetric modes was selected as the HITAF feed system. Two oxide dispersion-strengthened (ODS) alloys that would be used in the HITAF high-temperature heat exchanger were tested for slag corrosion rates. An alumina layer formed on one particular alloy, which was more corrosion-resistant than a chromia layer that formed on the other alloy. Research activities were completed in the development of an atmospheric pressure, fluidized-bed pyrolysis-type system called the controlled spontaneous reactor (CSR), which is used to process and condition biomass. Tree trimmings were physically and chemically altered by the CSR process, resulting in a fuel that was very suitable for feeding into a coal combustion or gasification system with little or no feed system modifications required. Experimental procedures were successful for producing hydrogen from biomass using the bacteria Thermotoga, a deep-ocean thermal vent organism. Analytical procedures for hydrogen were evaluated, a gas chromatography (GC) method was derived for measuring hydrogen yields, and adaptation culturing and protocols for mutagenesis were initiated to better develop strains that can use biomass cellulose. Fly ash derived from

  2. Utilization management in anatomic pathology.

    Science.gov (United States)

    Lewandrowski, Kent; Black-Schaffer, Steven

    2014-01-01

    There is relatively little published literature concerning utilization management in anatomic pathology. Nonetheless there are many utilization management opportunities that currently exist and are well recognized. Some of these impact only the cost structure within the pathology department itself whereas others reduce charges for third party payers. Utilization management may result in medical legal liabilities for breaching the standard of care. For this reason it will be important for pathology professional societies to develop national utilization guidelines to assist individual practices in implementing a medically sound approach to utilization management.

  3. Automated ISS Flight Utilities

    Science.gov (United States)

    Offermann, Jan Tuzlic

    2016-01-01

    During my internship at NASA Johnson Space Center, I worked in the Space Radiation Analysis Group (SRAG), where I was tasked with a number of projects focused on the automation of tasks and activities related to the operation of the International Space Station (ISS). As I worked on a number of projects, I have written short sections below to give a description for each, followed by more general remarks on the internship experience. My first project is titled "General Exposure Representation EVADOSE", also known as "GEnEVADOSE". This project involved the design and development of a C++/ ROOT framework focused on radiation exposure for extravehicular activity (EVA) planning for the ISS. The utility helps mission managers plan EVAs by displaying information on the cumulative radiation doses that crew will receive during an EVA as a function of the egress time and duration of the activity. SRAG uses a utility called EVADOSE, employing a model of the space radiation environment in low Earth orbit to predict these doses, as while outside the ISS the astronauts will have less shielding from charged particles such as electrons and protons. However, EVADOSE output is cumbersome to work with, and prior to GEnEVADOSE, querying data and producing graphs of ISS trajectories and cumulative doses versus egress time required manual work in Microsoft Excel. GEnEVADOSE automates all this work, reading in EVADOSE output file(s) along with a plaintext file input by the user providing input parameters. GEnEVADOSE will output a text file containing all the necessary dosimetry for each proposed EVA egress time, for each specified EVADOSE file. It also plots cumulative dose versus egress time and the ISS trajectory, and displays all of this information in an auto-generated presentation made in LaTeX. New features have also been added, such as best-case scenarios (egress times corresponding to the least dose), interpolated curves for trajectories, and the ability to query any time in the

  4. Gas utilization technologies

    Energy Technology Data Exchange (ETDEWEB)

    Biljetina, R.

    1994-09-01

    One of the constant challenges facing the research community is the identification of technology needs 5 to 15 years from now. A look back into history indicates that the forces driving natural gas research have changed from decade to decade. In the 1970s research was driven by concerns for adequate supply; in the 1980s research was aimed at creating new markets for natural gas. What then are the driving forces for the 1990s? Recent reports from the natural gas industry have helped define a new direction driven primarily by market demand for natural gas. A study prepared by the Interstate Natural Gas Association of America Foundation entitled ``Survey of Natural Research, Development, and Demonstration RD&D Priorities`` indicated that in the 1990s the highest research priority should be for natural gas utilization and that technology development efforts should not only address efficiency and cost, but environmental and regulatory issues as well. This study and others, such as the report by the American Gas Association (A.G.A.) entitled ``Strategic Vision for Natural Gas Through the Year 2000,`` clearly identify the market sectors driving today`s technology development needs. The biggest driver is the power generation market followed by the industrial, transportation, appliance, and gas cooling markets. This is best illustrated by the GRI 1994 Baseline Projection on market growth in various sectors between the year 1992 and 2010. This paper highlights some of the recent technology developments in each one of these sectors.

  5. PFBC Utility Demonstration Project

    Energy Technology Data Exchange (ETDEWEB)

    1992-11-01

    This report provides a summary of activities by American Electric Power Service Corporation during the first budget period of the PFBC Utility Demonstration Project. In April 1990, AEP signed a Cooperative Agreement with the US Department of Energy to repower the Philip Sporn Plant, Units 3 4 in New Haven, West Virginia, with a 330 KW PFBC plant. The purpose of the program was to demonstrate and verify PFBC in a full-scale commercial plant. The technical and cost baselines of the Cooperative Agreement were based on a preliminary engineering and design and a cost estimate developed by AEP subsequent to AEP's proposal submittal in May 1988, and prior to the signing of the Cooperative Agreement. The Statement of Work in the first budget period of the Cooperative Agreement included a task to develop a preliminary design and cost estimate for erecting a Greenfield plant and to conduct a comparison with the repowering option. The comparative assessment of the options concluded that erecting a Greenfield plant rather than repowering the existing Sporn Plant could be the technically and economically superior alternative. The Greenfield plant would have a capacity of 340 MW. The ten additional MW output is due to the ability to better match the steam cycle to the PFBC system with a new balance of plant design. In addition to this study, the conceptual design of the Sporn Repowering led to several items which warranted optimization studies with the goal to develop a more cost effective design.

  6. Facility Utilization Reports -  FAA Aviation Information Utilization Reports

    Data.gov (United States)

    Department of Transportation — Provides: (1) Space management and planning, including area calculations, tracking space by organization and employee, and monitoring space utilization information....

  7. Utility Computing: Reality and Beyond

    Science.gov (United States)

    Ivanov, Ivan I.

    Utility Computing is not a new concept. It involves organizing and providing a wide range of computing-related services as public utilities. Much like water, gas, electricity and telecommunications, the concept of computing as public utility was announced in 1955. Utility Computing remained a concept for near 50 years. Now some models and forms of Utility Computing are emerging such as storage and server virtualization, grid computing, and automated provisioning. Recent trends in Utility Computing as a complex technology involve business procedures that could profoundly transform the nature of companies' IT services, organizational IT strategies and technology infrastructure, and business models. In the ultimate Utility Computing models, organizations will be able to acquire as much IT services as they need, whenever and wherever they need them. Based on networked businesses and new secure online applications, Utility Computing would facilitate "agility-integration" of IT resources and services within and between virtual companies. With the application of Utility Computing there could be concealment of the complexity of IT, reduction of operational expenses, and converting of IT costs to variable `on-demand' services. How far should technology, business and society go to adopt Utility Computing forms, modes and models?

  8. Electric utility industry and planning

    Energy Technology Data Exchange (ETDEWEB)

    Schiffman, Y. (ed.)

    1983-01-01

    The objective of the workshop reported in these proceedings was to bring together planners, public officials, and community leaders with members of the utility industry to learn about utilities and to permit a meaningful exchange of information. This workshop was held at the Annual Meeting of the American Planning Association and its Energy Planning Division. The workshop was designed to inform planners about the electric-utility industry. A separate abstract was prepared for each of 4 individual presentations.

  9. VT Electric Utility Franchise Areas

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) ELCFRANCHISE includes Vermont's Electric Utility Franchise boundaries. It is a compilation of many data sources. The boundaries are approximate...

  10. The Evaluator's Responsibility for Utilization.

    Science.gov (United States)

    Patton, Michael Quinn

    1988-01-01

    The role of the evaluator in insuring utilization and quality of evaluation results is discussed. Topics covered include a utilization-focused vision of accountability, overcoming staff fears of evaluation, eliciting the right information from users, situational responsiveness, and advocacy. (TJH)

  11. Utility supply portfolio diversity requirements

    Energy Technology Data Exchange (ETDEWEB)

    Hanser, Philip; Graves, Frank

    2007-06-15

    In general, diversification for its own sake by utilities is likely to come at significant cost from ignoring or having to overcome engineering reasons for preferring a less diversified portfolio of resources. Integrated utilities, distcos and merchant gencos are likely to pursue widely divergent strategies in this regard. (author)

  12. Utility photovoltaic group: Status report

    Science.gov (United States)

    Serfass, Jeffrey A.; Hester, Stephen L.; Wills, Bethany N.

    1996-01-01

    The Utility PhotoVoltaic Group (UPVG) was formed in October of 1992 with a mission to accelerate the use of cost-effective small-scale and emerging grid-connected applications of photovoltaics for the benefit of electric utilities and their customers. The UPVG is now implementing a program to install up to 50 megawatts of photovoltaics in small-scale and grid-connected applications. This program, called TEAM-UP, is a partnership of the U.S. electric utility industry and the U.S. Department of Energy to help develop utility PV markets. TEAM-UP is a utility-directed program to significantly increase utility PV experience by promoting installations of utility PV systems. Two primary program areas are proposed for TEAM-UP: (1) Small-Scale Applications (SSA)—an initiative to aggregate utility purchases of small-scale, grid-independent applications; and (2) Grid-Connected Applications (GCA)—an initiative to identify and competitively award cost-sharing contracts for grid-connected PV systems with high market growth potential, or collective purchase programs involving multiple buyers. This paper describes these programs and outlines the schedule, the procurement status, and the results of the TEAM-UP process.

  13. Xylose utilization in recombinant Zymomonas

    Science.gov (United States)

    Kahsay, Robel Y; Qi, Min; Tao, Luan; Viitanen, Paul V; Yang, Jianjun

    2013-01-07

    Zymomonas expressing xylose isomerase from A. missouriensis was found to have improved xylose utilization, growth, and ethanol production when grown in media containing xylose. Xylose isomerases related to that of A. missouriensis were identified structurally through molecular phylogenetic and Profile Hidden Markov Model analyses, providing xylose isomerases that may be used to improve xylose utilization.

  14. Hualapai Tribal Utility Development Project

    Energy Technology Data Exchange (ETDEWEB)

    Hualapai Tribal Nation

    2008-05-25

    The first phase of the Hualapai Tribal Utility Development Project (Project) studied the feasibility of establishing a tribally operated utility to provide electric service to tribal customers at Grand Canyon West (see objective 1 below). The project was successful in completing the analysis of the energy production from the solar power systems at Grand Canyon West and developing a financial model, based on rates to be charged to Grand Canyon West customers connected to the solar systems, that would provide sufficient revenue for a Tribal Utility Authority to operate and maintain those systems. The objective to establish a central power grid over which the TUA would have authority and responsibility had to be modified because the construction schedule of GCW facilities, specifically the new air terminal, did not match up with the construction schedule for the solar power system. Therefore, two distributed systems were constructed instead of one central system with a high voltage distribution network. The Hualapai Tribal Council has not taken the action necessary to establish the Tribal Utility Authority that could be responsible for the electric service at GCW. The creation of a Tribal Utility Authority (TUA) was the subject of the second objective of the project. The second phase of the project examined the feasibility and strategy for establishing a tribal utility to serve the remainder of the Hualapai Reservation and the feasibility of including wind energy from a tribal wind generator in the energy resource portfolio of the tribal utility (see objective 2 below). It is currently unknown when the Tribal Council will consider the implementation of the results of the study. Objective 1 - Develop the basic organizational structure and operational strategy for a tribally controlled utility to operate at the Tribe’s tourism enterprise district, Grand Canyon West. Coordinate the development of the Tribal Utility structure with the development of the Grand Canyon

  15. Politics of public utility regulation

    Energy Technology Data Exchange (ETDEWEB)

    Gormley, W.T. Jr.

    1983-01-01

    Since the early 1970s, energy and telecommunications policies have emerged as increasingly complex and conflictual issues in state government and have, consequently, brought about change in the politics of public utilities regulation. In this analysis, Gormley shows that state public utilities commissions, in determining the rates that can be charged by private utility companies, must confront elected government officials, members of the state bureaucracy, citizens' groups, and the regulated industries themselves in a very visible, highly technical, costly, and controversial process that pits investors against consumers, business groups against residential consumers, consumer groups against environmentalists, and low-income consumers against consumers as a whole.

  16. State Drug Utilization Data 2013

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  17. State Drug Utilization Data 2012

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  18. State Drug Utilization Data 2001

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  19. State Drug Utilization Data 2000

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  20. State Drug Utilization Data 2008

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  1. State Drug Utilization Data 2003

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  2. State Drug Utilization Data 1999

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  3. State Drug Utilization Data 2009

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  4. State Drug Utilization Data 2011

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  5. State Drug Utilization Data 2014

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  6. State Drug Utilization Data 1994

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  7. State Drug Utilization Data 1991

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  8. State Drug Utilization Data 1995

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  9. State Drug Utilization Data 1993

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  10. State Drug Utilization Data 2004

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  11. State Drug Utilization Data 1992

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  12. State Drug Utilization Data 1997

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  13. State Drug Utilization Data 2005

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  14. State Drug Utilization Data 1996

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  15. State Drug Utilization Data 1998

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  16. State Drug Utilization Data 2006

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  17. State Drug Utilization Data 2010

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  18. State Drug Utilization Data 2007

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  19. State Drug Utilization Data 2002

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  20. State Drug Utilization Data 2016

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  1. Medicare Utilization for Part B

    Data.gov (United States)

    U.S. Department of Health & Human Services — This link takes you to the Medicare utilization statistics for Part B (Supplementary Medical Insurance SMI) which includes the Medicare Part B Physician and Supplier...

  2. Medicare Utilization for Part A

    Data.gov (United States)

    U.S. Department of Health & Human Services — This link takes you to the Medicare utilization statistics for Part A (Hospital Insurance HI) which include the Medicare Ranking for all Short-Stay Hospitals by...

  3. US Forest Service Land Utilization

    Data.gov (United States)

    US Forest Service, Department of Agriculture — A map service on the www depicting units designated by the Secretary of Agriculture for conservation and utilization under Title III of the Bankhead-Jones Farm...

  4. State Drug Utilization Data 2015

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  5. Growth of hydrocarbon utilizing microorganisms

    Digital Repository Service at National Institute of Oceanography (India)

    Bhosle, N.B.; Mavinkurve, S.

    Two isolates from marine mud having broad spectrum hydrocarbon utilizing profile were identified as Arthrobacter simplex and Candida tropicalis.Both the organisms grew exponentially on crude oil. The cell yield of the organisms was influenced...

  6. Cloud Computing Utility and Applications

    Directory of Open Access Journals (Sweden)

    Pradeep Kumar Tiwari

    2011-12-01

    Full Text Available Cloud Architecture provides services on demand basis via internet (WWW services. Application design in cloud computing environment or the applications which support cloud paradigm are on demand on the basis of user requirement. Those applications provide the support on various hardware, software and other resource requirement on demand. API used in the cloud computing provide the greater advantage to provide industrial strength, where the complex reliability and scalability logic of the underlying services remains implemented and hidden in the cloud environment. Cloud Computing provide the highest utilization in terms of utilization, resource sharing, requirement gathering and utility to the other needful resources. In this paper we discuss several utility and their applications. We provide a broad discussion which is useful for cloud computing research.

  7. State Drug Utilization Data 2017

    Data.gov (United States)

    U.S. Department of Health & Human Services — Drug utilization data are reported by states for covered outpatient drugs that are paid for by state Medicaid agencies since the start of the Medicaid Drug Rebate...

  8. Are CEOs Expected Utility Maximizers?

    OpenAIRE

    John List; Charles Mason

    2009-01-01

    Are individuals expected utility maximizers? This question represents much more than academic curiosity. In a normative sense, at stake are the fundamental underpinnings of the bulk of the last half-century's models of choice under uncertainty. From a positive perspective, the ubiquitous use of benefit-cost analysis across government agencies renders the expected utility maximization paradigm literally the only game in town. In this study, we advance the literature by exploring CEO's preferen...

  9. Lymphedema Prophylaxis Utilizing Perloperative Education

    Science.gov (United States)

    2005-09-01

    AD Award Number: DAMD17-00-1-0495 TITLE: Lymphedema Prophylaxis Utilizing Perloperative Education PRINCIPAL INVESTIGATOR: Mary Ann Kosir, M.D...NUMBER Lymphedema Prophylaxis Utilizing Perloperative Education 5b. GRANT NUMBER DAM D1 7-00-1-0495 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT...perioperative training for lymphedema assessment and protection. The hypothesis is that structured perioperative training in lymphedema protection will

  10. Burnout and health care utilization.

    Science.gov (United States)

    Jackson, C N; Manning, M R

    1995-01-01

    This study explores the relationship between burnout and health care utilization of 238 employed adults. Burnout was measured by the Maslach Burnout Inventory and health care utilization by insurance company records regarding these employees' health care costs and number of times they accessed health care services over a one year period. ANOVAs were conducted using Golembiewski and Munzenrider's approach to define the burnout phase. Significant differences in health care costs were found.

  11. How expensive is link utilization?

    OpenAIRE

    Stanojević, Rade; Shorten, Robert

    2007-01-01

    Understanding the relationship between queueing delays and link utilization for general traffic conditions is an important open problem in networking research. Difficulties in understanding this relationship stem from the fact that it depends on the complex nature of arriving traffic and the problems associated with modelling such traffic. Existing AQM schemes achieve a "low delay" and "high utilization" by responding early to congestion without considering the exact relationship betwee...

  12. Evaluating the Utility of Sluggish Cognitive Tempo in Discriminating among "DSM-IV" ADHD Subtypes

    Science.gov (United States)

    Harrington, Kelly M.; Waldman, Irwin D.

    2010-01-01

    The objective of the current study was to evaluate how the inclusion of 3 Sluggish Cognitive Tempo (SCT) symptoms in Attention-Deficit/Hyperactivity Disorder (ADHD) diagnostic criteria influences the external validity of the ADHD subtypes. The sample comprised 228 children (166 boys, 62 girls) ranging in age from 5-18 years who were referred to…

  13. Utility Solar Generation Valuation Methods

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Thomas N.; Dion, Phillip J.

    2009-06-30

    Tucson Electric Power (TEP) developed, tested and verified the results of a new and appropriate method for accurately evaluating the capacity credit of time variant solar generating sources and reviewed new methods to appropriately and fairly evaluate the value of solar generation to electric utilities. The project also reviewed general integrated approaches for adequately compensating owners of solar generation for their benefits to utilities. However, given the limited funding support and time duration of this project combined with the significant differences between utilities regarding rate structures, solar resource availability and coincidence of solar generation with peak load periods, it is well beyond the scope of this project to develop specific rate, rebate, and interconnection approaches to capture utility benefits for all possible utilities. The project developed computer software based evaluation method models to compare solar generation production data measured in very short term time increments called Sample Intervals over a typical utility Dispatch Cycle during an Evaluation Period against utility system load data. Ten second resolution generation production data from the SGSSS and actual one minute resolution TEP system load data for 2006 and 2007, along with data from the Pennington Street Garage 60 kW DC capacity solar unit installed in downtown Tucson will be applied to the model for testing and verification of the evaluation method. Data was provided by other utilities, but critical time periods of data were missing making results derived from that data inaccurate. The algorithms are based on previous analysis and review of specific 2005 and 2006 SGSSS production data. The model was built, tested and verified by in house TEP personnel. For this phase of the project, TEP communicated with, shared solar production data with and collaborated on the development of solar generation valuation tools with other utilities, including Arizona Public

  14. Back to Bentham? Explorations of experience utility

    NARCIS (Netherlands)

    Wakker, P.P.; Kahneman, D.; Sarin, R.K.

    1997-01-01

    Two core meanings of "utility" are distinguished. "Decision utility" is the weight of an outcome in a decision. "Experienced utility" is hedonic quality, as in Bentham's usage. Experienced utility can be reported in real time (instant utility), or in retrospective evaluations of past episodes

  15. Back to Bentham? Explorations of experience utility

    NARCIS (Netherlands)

    Wakker, P.P.; Kahneman, D.; Sarin, R.K.

    1997-01-01

    Two core meanings of "utility" are distinguished. "Decision utility" is the weight of an outcome in a decision. "Experienced utility" is hedonic quality, as in Bentham's usage. Experienced utility can be reported in real time (instant utility), or in retrospective evaluations of past episodes (remem

  16. Utilization and utility of clinical laboratory reports with graphical elements

    Directory of Open Access Journals (Sweden)

    Brian H Shirts

    2012-01-01

    Full Text Available Background: Graphical reports that contain charts, images, and tables have potential to convey information more effectively than text-based reports; however, studies have not measured how much clinicians value such features. We sought to identify factors that might influence the utilization of reports with graphical elements postulating that this is a surrogate for relative clinical utility of these graphical elements. Materials and Methods: We implemented a pilot project at ARUP laboratories to develop online enhanced laboratory test reports that contained graphical elements. We monitored on-demand clinician access to reports generated for 48 reportable tests over 22 months. We evaluated utilization of reports with graphical elements by clinicians at all institutions that use ARUP as a reference laboratory using descriptive statistics, regression, and meta-analysis tools to evaluate groups of similar test reports. Results: Median download rate by test was 8.6% with high heterogeneity in download rates between tests. Test reports with additional graphical elements were not necessarily downloaded more often than reports without these elements. Recently implemented tests and tests reporting abnormal results were associated with higher download rates (P < 0.01. Higher volume tests were associated with lower download rates (P = 0.03. Conclusions: In select cases graphical information may be clinically useful, particularly for less frequently ordered tests and in on reports of abnormal results. The utilization data presented could be used as a reference point for other laboratories planning on implementing graphical reporting. However, between-test heterogeneity was high and in many cases graphical elements may add little clinical utility, particularly if these merely reinforce information already contained in text based reports.

  17. E-Commerce for utilities

    Energy Technology Data Exchange (ETDEWEB)

    Malicky, M. [Metzler and Associates, Deerfield, IL (United States)

    1999-07-01

    The use of E-Commerce by energy utility and service companies was discussed. E-Commerce was described as being all communication via the web including Internet, Intranet and Extranet. E-Commerce communication includes the exchange of information, data, money services, products, ideas, conversations, knowledge, inventory and events. E-Commerce can be applied to electric and gas utilities to enhance energy marketing, delivery, retail energy, energy services, retail services and customer satisfaction. This means of communication is quickly becoming an essential part of customer care strategy. It reduces costs and improves performance. It was forecasted that E-Commerce will more than double from 1998 to 2001. 15 refs.

  18. Utility launches computer information service

    Energy Technology Data Exchange (ETDEWEB)

    Beaty, W. [ed.; Ordonez, B.

    1994-12-01

    Three employees at Lee County Electric Cooperative in North Fort Meyers, Fla., have developed InterLine, an on-line computer service designed specifically for the electric utility industry. Since introducing InterLine to the public, the development team has been looking at what areas of information would be most useful to subscribers. In the initial phase, system features include forums on electrical engineering, safety and health and transmission and distribution, a library of files and the Internet gateway. If InterLIne is embraced by the electric utility industry, long range plans are to take it internationls.

  19. Utility Energy Services Contracts: Enabling Documents

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-05-01

    Utility Energy Services Contracts: Enabling Documents provides materials that clarify the authority for Federal agencies to enter into utility energy services contracts (UESCs), as well as sample documents and resources to ease utility partnership contracting.

  20. Expected utility with lower probabilities

    DEFF Research Database (Denmark)

    Hendon, Ebbe; Jacobsen, Hans Jørgen; Sloth, Birgitte

    1994-01-01

    An uncertain and not just risky situation may be modeled using so-called belief functions assigning lower probabilities to subsets of outcomes. In this article we extend the von Neumann-Morgenstern expected utility theory from probability measures to belief functions. We use this theory...

  1. Production and utilization of radioisotopes

    Energy Technology Data Exchange (ETDEWEB)

    Sekine, Toshiaki [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Matsuoka, Hiromitsu

    1999-03-01

    A plan of developing radioisotopes with a high power proton accelerator of the Neutron Science Project is presented. The status of production and utilization of radioisotopes in Japan is briefly discussed. The radioisotopes to be produced for biomedical use are discussed together with the facility for production of those radioisotopes and for research with the products. (author)

  2. 1999 international ash utilization symposium

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    112 papers were presented covering various aspects of the utilization of coal and other combustion products. Topics included fundamental chemistry and mineralogy, new products, health and environmental aspects, economic development issues, agricultural and mine reclamation applications, concrete and cement, and fly ash beneficiation technologies. Selected papers will be published in the journal 'Fuel'.

  3. Administrative Utility Analysis: Study Summary.

    Science.gov (United States)

    Peat, Marwick, Mitchell and Co., San Juan, Puerto Rico.

    This document summarizes the recommendations made as a result of a study on administrative utility analysis and vocational education programs for Puerto Rico. The major recommendation was that the Area of Vocational and Technical Education (AVTE) in the Puerto Rico Department of Education be restructured at the central organizational level, for…

  4. Module Utilization Committee. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1984-03-01

    Photovoltaic collector modules were declared surplus to the needs of the US Department of Energy. The Module Utilization Committee was formed to make appropriate disposition of the surplus modules. The final report of that committee accounts for that disposition. The membership and activities of the committee are set forth and the results of its activities are reported.

  5. Wind energy utilization: A bibliography

    Science.gov (United States)

    1975-01-01

    Bibliography cites documents published to and including 1974 with abstracts and references, and is indexed by topic, author, organization, title, and keywords. Topics include: Wind Energy Potential and Economic Feasibility, Utilization, Wind Power Plants and Generators, Wind Machines, Wind Data and Properties, Energy Storage, and related topics.

  6. Zymomonas with improved xylose utilization

    Science.gov (United States)

    Viitanen, Paul V [West Chester, PA; Tao, Luan [Havertown, PA; Zhang, Yuying [New Hope, PA; Caimi, Perry G [Kennett Square, PA; McCutchen, Carol M [Wilmington, DE; McCole, Laura [East Fallowfield, PA; Zhang, Min [Lakewood, CO; Chou, Yat-Chen [Lakewood, CO; Franden, Mary Ann [Centennial, CO

    2011-08-16

    Strains of Zymomonas were engineered by introducing a chimeric xylose isomerase gene that contains a mutant promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene. The promoter directs increased expression of xylose isomerase, and when the strain is in addition engineered for expression of xylulokinase, transaldolase and transketolase, improved utilization of xylose is obtained.

  7. Utility of spoken dialog systems

    CSIR Research Space (South Africa)

    Barnard, E

    2008-12-01

    Full Text Available the evolution of poken dialog system research in the developed world, and show that the utility of speech is based on user factors and application factors (among others). After adjusting the factors for the developing world context, and plotting...

  8. Utilization and management of alder.

    Science.gov (United States)

    David G. Briggs; Dean S. DeBell; William A. Atkinson

    1978-01-01

    In the Pacific Northwest and British Columbia, red alder often grows on forest lands following natural or man-caused disturbances. Frequently ignored as a pest or weed, many alder stands have developed to the point where important utilization and management questions are being asked. It is recognized that alder is a fast growing species, and that its rapid early growth...

  9. The Library Space Utilization Methodology.

    Science.gov (United States)

    Hall, Richard B.

    1978-01-01

    Describes the Library Space Utilization (LSU) methodology, which demonstrates that significant information about the functional requirements of a library can be measured and displayed in a quantitative and graphic form. It measures "spatial" relationships between selected functional divisions; it also determines how many people--staff and…

  10. Subjective ambiguity, expected utility and Choquet expected utility

    OpenAIRE

    Jiankang Zhang

    2002-01-01

    Using the Savage set up, this paper provides a simple axiomatization of the Choquet Expected Utility model where the capacity is an inner measure. Two attractive features of the model are its specificity and the transparency of its axioms. The key axiom states that the decision-maker uses unambiguous acts to approximate ambiguous ones. In addition, the notion of `ambiguity' is subjective and derived from preferences.

  11. Forward SCT Module Assembly and Quality Control at IFIC Valencia

    CERN Document Server

    Mitsou, V A; Civera, J V; Costa, M J; Escobar, C; Fuster, J; García, C; García-Navarro, J E; González, F; González-Sevilla, S; Lacasta, C; Llosá, G; Martí i García, S; Miñano, M; Modesto, P; Nácher, J; Rodríguez-Oliete, R; Sánchez, F J; Sospedra, L; Strachko, V

    2007-01-01

    This note discusses the assembly and the quality control tests of 282 forward detector modules for the ATLAS Semiconductor Tracker assembled at the Instituto de Fisica Corpuscular (IFIC) in Valencia. The construction and testing procedures are outlined and the laboratory equipment is briefly described. Emphasis is given on the module quality achieved in terms of mechanical and electrical stability.

  12. Radiation-hard optoelectronic data readout for the ATLAS SCT

    CERN Document Server

    Troska, Jan K; Gregor, I M; Homer, R James; Jovanovic, P; Mahout, G; Mandic, I; Wastie, R L; Weidberg, A R; White, D J

    2000-01-01

    The ATLAS experiment is currently in the final pre-production design phase to allow timely installation at the CERN Large Hadron Collider in 2005. The sub-systems closest to the interaction point the tracking detectors, will be subject to significant total radiation dose at high flux. Optical data transmission has been chosen for the Pixel and SemiConductor Tracker to both deliver timing and control information to the detector modules and transmit tracking data to the remote counting room. Of considerable concern is the radiation hardness, both transient and total dose, of not just the optoelectronic components but also the driver/receiver electronics. In this paper we report on total dose radiation testing of the VCSEL driver and photodiode receiver ASICs designed using a range of techniques in a nominally radiation-soft process. Both ASICs will be shown to be tolerant to a total gamma dose of 100 kGy and a total neutron fluence (1 MeV equiv.) of 2*10/sup 14/ n/cm/sup 2/, as required for this system. Single-...

  13. RTNS-II utilization plan

    Energy Technology Data Exchange (ETDEWEB)

    Zwilsky, Klaus M.

    1978-09-01

    This plan describes a general program for the effective utilization of this resource by the fusion materials community. Because its flux is low relative to levels expected in commercial fusion reactors, the RINS-II is not expected to produce data of direct engineering significance (with some exceptions). Rather, it will be used chiefly to aid in the development of models of high energy neutron effects. Such models are needed in projecting engineering data obtained in high flux fission reactors to the fusion environment. Fission reactors, because of their relatively soft neutron spectra, cannot produce the high ratio of transmutations to displacements (except in an important special case) or the high energy recoil atoms appropriate to fusion reactors utilizing the D-T reaction.

  14. Introduction to drug utilization research

    DEFF Research Database (Denmark)

    Wettermark, Björn; Elseviers, Monique; Almarsdóttir, Anna Birna

    2016-01-01

    Qualitative research methods derive from the social sciences. Their use in drug utilization research is increasingly widespread, especially in understanding patient and prescriber perspectives. The main focus in qualitative research is exploration of a given phenomenon in order to get a wider und...... understanding of why and how it appears. Qualitative research methods build on various theoretical underpinnings/schools of thought. The same validity and quality criteria cannot be used for both qualitative and quantitative methods.......Qualitative research methods derive from the social sciences. Their use in drug utilization research is increasingly widespread, especially in understanding patient and prescriber perspectives. The main focus in qualitative research is exploration of a given phenomenon in order to get a wider...

  15. Utilization of the terrestrial cyanobacteria

    Science.gov (United States)

    Katoh, Hiroshi; Tomita-Yokotani, Kaori; Furukawa, Jun; Kimura, Shunta; Yokoshima, Mika; Yamaguchi, Yuji; Takenaka, Hiroyuki

    The terrestrial, N _{2}-fixing cyanobacterium, Nostoc commune has expected to utilize for agriculture, food and terraforming cause of its extracellular polysaccharide, desiccation tolerance and nitrogen fixation. Previously, the first author indicated that desiccation related genes were analyzed and the suggested that the genes were related to nitrogen fixation and metabolisms. In this report, we suggest possibility of agriculture, using the cyanobacterium. Further, we also found radioactive compounds accumulated N. commune (cyanobacterium) in Fukushima, Japan after nuclear accident. Thus, it is investigated to decontaminate radioactive compounds from the surface soil by the cyanobacterium and showed to accumulate radioactive compounds using the cyanobacterium. We will discuss utilization of terrestrial cyanobacteria under closed environment. Keyword: Desiccation, terrestrial cyanobacteria, bioremediation, agriculture

  16. Tactical Utility of Tailored Systems

    Science.gov (United States)

    2015-07-10

    www.popsci.com/ cars /article/2011-06/how-first- crowdsourced-military- car -can-remake-future-defense- manufacturing Tactical Utility of Tailored Systems...year lead time to develop a piece of equipment, if we were able to collapse the pace of which that manufacturing takes place, that would save taxpayers...within budget. This paper hopes to explore the idea of combining virtual environments and rapid manufacturing to create tailored materiel specific

  17. Purdue Solar Energy Utilization Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Agrawal, Rakesh [Purdue

    2014-01-21

    The objective of this project is to establish and set-up a laboratory that will facilitate research and development of new low-cost and high-efficiency solar energy utilization technologies at Purdue University. The outcome will help spur the creation of solar energy start-up companies and eventually a solar energy industry in Indiana that can help fulfill the growing national demand for solar energy.

  18. Microorganism Utilization for Synthetic Milk

    Science.gov (United States)

    Morford, Megan A.; Khodadad, Christina L.; Caro, Janicce I.; Spencer, LaShelle E.; Richards, Jeffery T.; Strayer, Richard F.; Birmele, Michele N.; Wheeler, Raymond M.

    2014-01-01

    A desired architecture for long duration spaceflight, like aboard the International Space Station or for future missions to Mars, is to provide a supply of fresh food crops for the astronauts. However, some crops can create a high proportion of inedible plant waste. The main goal of the Synthetic Biology project, Cow in a Column, was to produce the components of milk (sugar, lipid, protein) from inedible plant waste by utilizing microorganisms (fungi, yeast, bacteria). Of particular interest was utilizing the valuable polysaccharide, cellulose, found in plant waste, to naturally fuel-through microorganism cellular metabolism- the creation of sugar (glucose), lipid (milk fat), and protein (casein) in order to produce a synthetic edible food product. Environmental conditions such as pH, temperature, carbon source, aeration, and choice microorganisms were optimized in the laboratory and the desired end-products, sugars and lipids, were analyzed. Trichoderma reesei, a known cellulolytic fungus, was utilized to drive the production of glucose, with the intent that the produced glucose would serve as the carbon source for milk fat production and be a substitute for the milk sugar lactose. Lipid production would be carried out by Rhodosporidium toruloides, yeast known to accumulate those lipids that are typically found in milk fat. Results showed that glucose and total lipid content were below what was expected during this phase of experimentation. In addition, individual analysis of six fatty acids revealed that the percentage of each fatty acid was lower than naturally produced bovine milk. Overall, this research indicates that microorganisms could be utilized to breakdown inedible solid waste to produce useable products. For future work, the production of the casein protein for milk would require the development of a genetically modified organism, which was beyond the scope of the original project. Additional trials would be needed to further refine the required

  19. Comprehensive utilization of digested residue

    Energy Technology Data Exchange (ETDEWEB)

    Reizhi Shen [Soil and Fertilizer Inst. of Shanghai Academy of Agricultural Sciences (China)

    2000-07-01

    The application history of biogas technology in China covers almost one century. Until the 1980's, people's attention not only focused on the benefit of biogas as people's daily fuel, but also on the comprehensive utilization of digested residues. People are more and more interested in these methods of comprehensive utilization, which has led to many research projects on, among others, ''digested effluent as feed additive for pigs'', ''digested sludge for growing mushroom'', and ''digested effluent as pesticide''. Not only are biogas fermentation, organic waste such as animal manure, crop straw, distillery wastewater and the wastewater from slaughter houses converted to biogas, but also digested residues are very useful with a lot of ''potential value'' and ''special functions'', which will bring far more benefits than biogas alone. Some progress on the comprehensive utilization of digested residues in the past ten years is summarized below. (orig.)

  20. Simple utility functions with Giffen demand

    DEFF Research Database (Denmark)

    Sørensen, Peter Norman

    2007-01-01

    Simple utility functions with the Giffen property are presented: locally, the demand curve for a good is upward sloping. The utility functions represent continuous, monotone, convex preferences......Simple utility functions with the Giffen property are presented: locally, the demand curve for a good is upward sloping. The utility functions represent continuous, monotone, convex preferences...

  1. Promotion of HANARO Utilization for Year 2006

    Energy Technology Data Exchange (ETDEWEB)

    Sohn, J. M.; Kim, H. R.; Jun, B. J. (and others)

    2007-05-15

    To activate the HANARO utilization by expanding HANARO utilization fields, recruiting and training new users. In order to promote the HANARO utilization, the following activities have been performed. The neutron usage fee in HANARO. Achievements of HANARO utilization. Project for Activation of the Research using HANARO. HANARO Symposium. Survey of the HANARO User Satisfaction Index. Operation and Management of HANARO Server. Management of HANARO related committees. Training of HANARO users. Related activities of HANARO publicity. The related activities to activate HANARO utilization have been carried out successfully. This report summarized the detailed activities to activate the HANARO utilization. They will be useful for expanding HANARO utilization in the near future.

  2. Recent trend in coal utilization technology. Coal utilization workshop

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Chon Ho; Son, Ja Ek; Lee, In Chul; Jin, Kyung Tae; Kim, Seong Soo [Korea Inst. of Energy Research, Taejon (Korea, Republic of)

    1995-12-01

    The 11th Korea-U.S.A. joint workshop on coal utilization technology was held in somerset, Pennsylvania, U.S.A. from october 2 to 3, 1995. In the opening ceremony, Dr.C. Low-el Miller, associate deputy assistant secretary of office of clean coal technology, U.S.DOE, gave congratulatory remarks and Dr. Young Mok Son, president of KIER, made a keynote address. In this workshop, 30 papers were presented in the fields of emission control technology, advanced power generation systems, and advanced coal cleaning and liquid fuels. Especially, from the Korean side, not only KIER but also other private research institutes and major engineering companies including KEPCO, Daewoo Institute of Construction Technology, Jindo Engineering and Construction Co. Daewoo Institute for Advanced Engineering and universities participated in this workshop, reflecting their great interests. Attendants actively discussed about various coal utilization technologies and exchanged scientific and technical information on the state-of-art clean coal technologies under development. (author)

  3. Vision 2021. The utilities future

    Energy Technology Data Exchange (ETDEWEB)

    Liere, J. van [KEMA, Arnhem (Netherlands)

    1996-12-01

    The electricity industry is gradually making the transition to a free market economy characterized by competition. With the arrival of a more market-oriented structure, the electricity companies have taken measures to reduce costs while retaining reliability and safety of the production and distribution. Today the majority of these efforts are oriented towards optimizing the scope and the structure of the organizations and towards streamlining internal processes in order to improve productivity. Throughout the world, the increasing competition among utilities is accompanied by the unbundling of production, transport, distribution and customer service functions. There is a remarkable similarity between the transitions in the computer industry some years ago (from main frame to personal PC`s) and in the electric utility industry today. The new structure is expected to be less centralized and more dispersed. In the dispersed generation concept the locally deployed power plant must become smaller, more flexible, more efficient and less expensive than today`s power plants. Power generation is gradually changing from a steam cycle (Rankine cycle) via the combined cycle to the gas cycle (Brayton cycle). The fuel used to power the gas turbine is expected to change in the future from high calorific to low calorific gas, generated from biomass, waste, oil residues, blast furnaces, coal, etc. Five new areas to be addressed have been identified that can be characterized as follows: (a) improved utilization of capital-intensive production resources to reduce costs, (b) electrification and the supply of heat to increase sales and market share, (c) sustainable developments to broaden our future resource base, (d) improved efficiency based on the Brayton cycle to increase flexibility, (e) development of energy services with new secondary services to stay in the market. (EG) 10 refs.

  4. Optical Isolator Utilizing Surface Plasmons

    Directory of Open Access Journals (Sweden)

    Shinji Yuasa

    2012-05-01

    Full Text Available Feasibility of usage of surface plasmons in a new design of an integrated optical isolator has been studied. In the case of surface plasmons propagating at a boundary between a transition metal and a double-layer dielectric, there is a significant difference of optical loss for surface plasmons propagating in opposite directions. Utilizing this structure, it is feasible to fabricate a competitive plasmonic isolator, which benefits from a broad wavelength operational bandwidth and a good technological compatibility for integration into the Photonic Integrated Circuits (PIC. The linear dispersion relation was derived for plasmons propagating in a multilayer magneto-optical slab.

  5. Direct Utilization of Geothermal Energy

    Directory of Open Access Journals (Sweden)

    John W. Lund

    2010-08-01

    Full Text Available The worldwide application of geothermal energy for direct utilization is reviewed. This paper is based on the world update for direct-use presented at the World Geothermal Congress 2010 in Bali, Indonesia (WGC2010 [1] which also includes material presented at three world geothermal congresses in Italy, Japan and Turkey (WGC95, WGC2000 and WGC2005. This report is based on country update papers prepared for WGC2010 and data from other sources. Final update papers were received from 70 countries of which 66 reported some direct utilization of geothermal energy for WGC2010. Twelve additional countries were added to the list based on other sources of information. The 78 countries having direct utilization of geothermal energy, is a significant increase from the 72 reported in 2005, the 58 reported in 2000, and the 28 reported in 1995. An estimate of the installed thermal power for direct utilization at the end of 2009, reported from WGC2010 is 48,493 MWt, almost a 72 % increased over the 2005 data, growing at a compound rate of 11.4% annually with a capacity factor of 0.28. The thermal energy used is 423,830 TJ/year (117,740 GWh/yr, about a 55% increase over 2005, growing at a compound rate of 9.2% annually. The distribution of thermal energy used by category is approximately 47.2% for ground-source heat pumps, 25.8% for bathing and swimming (including balneology, 14.9% for space heating (of which 85% is for district heating, 5.5% for greenhouses and open ground heating, 2.8% for industrial process heating, 2.7% for aquaculture pond and raceway heating, 0.4% for agricultural drying, 0.5% for snow melting and cooling, and 0.2% for other uses. Energy savings amounted to 250 million barrels (38 million tonnes of equivalent oil annually, preventing 33 million tonnes of carbon and 107 million tonnes of CO2 being release to the atmosphere which includes savings in geothermal heat pump cooling (compared to using fuel oil to generate electricity.

  6. Asymptotics of robust utility maximization

    CERN Document Server

    Knispel, Thomas

    2012-01-01

    For a stochastic factor model we maximize the long-term growth rate of robust expected power utility with parameter $\\lambda\\in(0,1)$. Using duality methods the problem is reformulated as an infinite time horizon, risk-sensitive control problem. Our results characterize the optimal growth rate, an optimal long-term trading strategy and an asymptotic worst-case model in terms of an ergodic Bellman equation. With these results we propose a duality approach to a "robust large deviations" criterion for optimal long-term investment.

  7. Cooling clothing utilizing water evaporation

    DEFF Research Database (Denmark)

    Sakoi, Tomonori; Tominaga, Naoto; Melikov, Arsen Krikor

    2014-01-01

    We developed cooling clothing that utilizes water evaporation to cool the human body and has a mechanism to control the cooling intensity. Clean water was supplied to the outer surface of the T-shirt of the cooling clothing, and a small fan was used to enhance evaporation on this outer surface...... temperature ranging from 27.4 to 30.7 °C to establish a suitable water supply control method. A water supply control method that prevents water accumulation in the T-shirt and water dribbling was validated; this method is established based on the concept of the water evaporation capacity under the applied...

  8. Utilization of Fatliquors by Fungi

    Directory of Open Access Journals (Sweden)

    O. P. Sharma

    1980-04-01

    Full Text Available wenty five fungi isolated from deteriorated finished leathers have been tested to know their relative capacity to utilize the fatliquors viz., raw fish oil, castor oil, fish oil (sulphated, spindle oil turkey red oil and coconut oil. All these fatty substances supported the growth of all the fungi except a few species of Aspergillus, Trichoderma and Drechslera which showed moderate growth. The studies support the contention that fatliquors initially provide a substrate for the growth of fungi on finished leather and its products.

  9. Utilizing inheritance in requirements engineering

    Science.gov (United States)

    Kaindl, Hermann

    1994-01-01

    The scope of this paper is the utilization of inheritance for requirements specification, i.e., the tasks of analyzing and modeling the domain, as well as forming and defining requirements. Our approach and the tool supporting it are named RETH (Requirements Engineering Through Hypertext). Actually, RETH uses a combination of various technologies, including object-oriented approaches and artificial intelligence (in particular frames). We do not attempt to exclude or replace formal representations, but try to complement and provide means for gradually developing them. Among others, RETH has been applied in the CERN (Conseil Europeen pour la Rechereche Nucleaire) Cortex project. While it would be impossible to explain this project in detail here, it should be sufficient to know that it deals with a generic distributed control system. Since this project is not finished yet, it is difficult to state its size precisely. In order to give an idea, its final goal is to substitute the many existing similar control systems at CERN by this generic approach. Currently, RETH is also tested using real-world requirements for the Pastel Mission Planning System at ESOC in Darmstadt. First, we outline how hypertext is integrated into a frame system in our approach. Moreover, the usefulness of inheritance is demonstrated as performed by the tool RETH. We then summarize our experiences of utilizing inheritance in the Cortex project. Lastly, RETH will be related to existing work.

  10. Hypertext Cross-Reference Utilities

    Science.gov (United States)

    Warren-Smith, R. F.; Draper, P. W.

    This document describes a set of ``Hypertext Cross-Reference Utilities'' (HTX) which are designed to help maintain large documentation sets whose constituent documents are written using the Hypertext Markup Languagee (HTML). The central part of HTX is a hypertext linker, hlink. This allows hyper-links (or cross-references) to be established between related documents in such a way that it is easy to maintain their integrity as individual documents are updated. Information produced by this linking process is also used by other HTX utilities to provide document search facilities and the ability to randomly access any part of a documentation set. This latter capability forms a basis for constructing hypertext help systems for use by other software. The expected readership of this document includes those who read hypertext documentation, those who write it, and those who maintain it, especially those who write and maintain Starlink documentation. Software developers may also be interested in the possibilities for hypertext help that HTX provides.

  11. Utilities:Power:Power-Related Utilities at Pipe Spring National Monument, Arizona (Utilities.gdb:Power:utilpnt_power)

    Data.gov (United States)

    National Park Service, Department of the Interior — This feature class represents power-related utilities at Pipe Spring National Monument, Arizona. The utilities were collected using Trimble Global Positioning System...

  12. Advanced clean coal utilization technologies

    Energy Technology Data Exchange (ETDEWEB)

    Moritomi, Hiroshi [National Inst. for Resources and Environment, Tsukuba, Ibaraki (Japan)

    1993-12-31

    The most important greenhouse gas is CO{sub 2} from coal utilization. Ways of mitigating CO{sub 2} emissions include the use of alternative fuels, using renewable resources and increasing the efficiency of power generation and end use. Adding to such greenhouse gas mitigation technologies, post combustion control by removing CO{sub 2} from power station flue gases and then storing or disposing it will be available. Although the post combustion control have to be evaluated in a systematic manner relating them to whether they are presently available technology, to be available in the near future or long term prospects requiring considerable development, it is considered to be a less promising option owing to the high cost and energy penalty. By contrast, abatement technologies aimed at improving conversion efficiency or reducing energy consumption will reduce emissions while having their own commercial justification.

  13. Micrograin Superplasticity: Characteristics and Utilization

    Directory of Open Access Journals (Sweden)

    Farghalli A. Mohamed

    2011-07-01

    Full Text Available Micrograin Superplasticity refers to the ability of fine-grained materials (1 µm < d < 10 μm, where d is the grain size to exhibit extensive neck-free elongations during deformation at elevated temperatures. Over the past three decades, good progress has been made in rationalizing this phenomenon. The present paper provides a brief review on this progress in several areas that have been related to: (a the mechanical characteristics of micrograin superplasticity and their origin; (b the effect of impurity content and type on deformation behavior, boundary sliding, and cavitation during superplastic deformation; (c the formation of cavity stringers; (d dislocation activities and role during superplastic flow; and (e the utilization of superplasticity.

  14. Personal genetics: sports utility vehicle?

    Science.gov (United States)

    Grimaldi, Keith Anthony; Paoli, Antonio; Smith, Graeme John

    2012-12-01

    Personal genetic testing which is not strictly related to medicine or health is becoming more and more popular covering areas from ancestry, genealogy, nutrition& lifestyle and more recently sports and exercise. The reasons are compelling - if it were possible to read in our genes our potential sporting attributes and how to achieve them it would be valuable information. But is it possible? This overview will look at the current situation and future prospects the authors believe that there is utility in sports genetic testing exactly what can be interpreted from our genetic results needs to be precisely defined and limited to what has been demonstrated by repeated scientific studies. Current areas of interest include optimizing exercise/training routines, VO2max improvement and predisposition to some common sports related injuries such as tendonitis. The interest and the scientific progress is reflected both in increasing rate of publication of geneexercise studies as well as in patent applications concerning genetic associations with commercial potential.

  15. Capacity Utilization in European Railways

    DEFF Research Database (Denmark)

    Khadem Sameni, Melody; Landex, Alex

    2013-01-01

    At the strategic level, railways currently use different indices to estimate how ‘value’ is generated by using railway capacity. However, railway capacity is a multidisciplinary area, and attempts to develop various indices cannot provide a holistic measure of operational efficiency. European...... railways are facing a capacity challenge which is caused by passenger and freight demand exceeding the track capacity supply. In the absence of a comprehensive railway capacity manual, methodologies are needed to assess how well railways use their track capacity. This paper presents a novel...... and unprecedented approach for this aim. Relative operational efficiency of 24 European railways in capacity utilization is studied for the first time by data envelopment analysis (DEA). It deviates from previous applications of DEA in the railway industry that are conducted to analyze cost efficiency of railways...

  16. Aspects of carbon dioxide utilization

    Energy Technology Data Exchange (ETDEWEB)

    Omae, Iwao [Omae Research Laboratories, 335-23 Mizuno, Sayama, Saitama 350-1317 (Japan)

    2006-06-30

    Carbon dioxide reacts with hydrogen, alcohols, acetals, epoxides, amines, carbon-carbon unsaturated compounds, etc. in supercritical carbon dioxide or in other solvents in the presence of metal compounds as catalysts. The products of these reactions are formic acid, formic acid esters, formamides, methanol, dimethyl carbonate, alkylene carbonates, carbamic acid esters, lactones, carboxylic acids, polycarbonate (bisphenol-based engineering polymer), aliphatic polycarbonates, etc. Especially, the productions of formic acid, formic acid methyl ester and dimethylformamide with a ruthenium catalyst; dimethyl carbonate and urethanes with a dialkyltin catalyst; 2-pyrone with a nickel-phosphine catalyst; diphenyl carbonate with a lead phenoxide catalyst; the alternating copolymerization of carbon dioxide and epoxides with a zinc catalyst has attracted attentions as the industrial utilizations of carbon dioxide. The further development of these production processes is expected. (author)

  17. Resourceful Utilization of Tannery Wastewater

    Institute of Scientific and Technical Information of China (English)

    Wang Chen; Wang Xikui; Ding Maochen; Zhang Chaoyu

    2012-01-01

    Leather industry is an important light industry in China. Leather making requires a series of chemical treatment. Degreasing, unhairing and chrome tanning wastewaters are the main portions of tannery wastewater. Reclaiming and reusing these wastewaters can eliminate 80% of COD, 75% of BOD, 95% of chromium and 93% of sulfuret, furthermore reduce environment impact, decrease treatment costs, save chemicals and water. Some application methods of wastewater reclamation and reuse for dif- ferent operations were reported. The suitable reclamation and reuse technologies can enable leather making processes more ra- tional, and realize the recovery and recycle of several chemicals in the tannery. Resourceful utilization of tannery wastewater should mate with renovating production technology, updating equipment, and must be guaranteed sufficiently by environmental protection measures.

  18. Molecular mechanisms of thiamine utilization.

    Science.gov (United States)

    Singleton, C K; Martin, P R

    2001-05-01

    Thiamine is required for all tissues and is found in high concentrations in skeletal muscle, heart, liver, kidneys and brain. A state of severe depletion is seen in patients on a strict thiamine-deficient diet in 18 days, but the most common cause of thiamine deficiency in affluent countries is alcoholism. Thiamine diphosphate is the active form of thiamine, and it serves as a cofactor for several enzymes involved primarily in carbohydrate catabolism. The enzymes are important in the biosynthesis of a number of cell constituents, including neurotransmitters, and for the production of reducing equivalents used in oxidant stress defenses and in biosyntheses and for synthesis of pentoses used as nucleic acid precursors. Because of the latter fact, thiamine utilization is increased in tumor cells. Thiamine uptake by the small intestines and by cells within various organs is mediated by a saturable, high affinity transport system. Alcohol affects thiamine uptake and other aspects of thiamine utilization, and these effects may contribute to the prevalence of thiamine deficiency in alcoholics. The major manifestations of thiamine deficiency in humans involve the cardiovascular (wet beriberi) and nervous (dry beriberi, or neuropathy and/or Wernicke-Korsakoff syndrome) systems. A number of inborn errors of metabolism have been described in which clinical improvements can be documented following administration of pharmacological doses of thiamine, such as thiamine-responsive megaloblastic anemia. Substantial efforts are being made to understand the genetic and biochemical determinants of inter-individual differences in susceptibility to development of thiamine deficiency-related disorders and of the differential vulnerabilities of tissues and cell types to thiamine deficiency.

  19. Utility Energy Services Contracts Lessons Learned

    Energy Technology Data Exchange (ETDEWEB)

    None

    2001-08-01

    This document describes best practices in the use of Utility Energy Services Contracts. The recommendations were generated by a group of innovative energy managers in many successful projects. The topics include project financing, competition between utility franchises, and water conservation.

  20. Utility Incentives for Combined Heat and Power

    Science.gov (United States)

    This report describes the results of EPA's research and analysis into utility incentives for CHP. It provides information about utility-initiated policies, programs, and incentives for CHP systems, and includes case studies and tools and resources.

  1. Utility Energy Services Contracts: Enabling Documents

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, Karen; Vasquez, Deb

    2017-01-01

    The Federal Energy Management Program's 'Utility Energy Service Contracts: Enabling Documents' provide legislative information and materials that clarify the authority for federal agencies to enter into utility energy service contracts, or UESCs.

  2. 31. FACTORS INFLUENCING UTILIZATION OF INTERMITTENT ...

    African Journals Online (AJOL)

    Esem

    treatment of malaria during pregnancy(IPTp), effective IPTp service utilization ... effective case management of malaria. Despite the ... Factors influencing IPTp utilization identified in the study included; educational status of a woman,. Medical ...

  3. Urban ecology and the municipal utilities

    DEFF Research Database (Denmark)

    Nielsen, Susanne Balslev

    1998-01-01

    Current management of municipal utilities for energy, water and solid waste is often in conflict with the ideas of ecological demonstrationprojects. The writer argue there is a need of transformation within municipal utilities and a need of new planning tools......Current management of municipal utilities for energy, water and solid waste is often in conflict with the ideas of ecological demonstrationprojects. The writer argue there is a need of transformation within municipal utilities and a need of new planning tools...

  4. Antifungal prophylaxis in stem cell transplantation centers in Turkey

    Directory of Open Access Journals (Sweden)

    Hamdi Akan

    2011-12-01

    Full Text Available Objective: This study aimed to determine the current state of antifungal prophylaxis in Turkish stem cell transplantation (SCT centers. Materials and Methods: The were 38 active stem cell transplantation centers in Turkey, 28 of which were registered with the European Group for Blood and Marrow Transplantation (EBMT. Survey questionnaires were sent to the 28 EBMT centers in an effort to collect data on antifungal prophylaxis in different settings. In all, 24 of the centers completed the survey; 1 of the 24 centers was excluded from the study, as it was under construction at the time and was not performing transplantation.Results: In all, 15 (65% of the 23 centers were adult SCT centers, 7 (31% were pediatric SCT centers, and 1 center treated both adult and pediatric patients. All centers (23/23 performed both allogeneic and autologous transplants, 20 centers performed non-myeloablative transplants, 8 performed cord blood transplants, and 7 performed unrelated transplants. Primary antifungal prophylaxis was used at all 23 centers during allogeneic transplants, whereas 18 of the 23 centers used it during every autologous transplant and 2 of the 23 centers used it during autologous transplants on a per case basis. The most common drug used for prophylaxis was fluconazole (F (21/23, followed by itraconazole (I (3/23, amphotericin-B (2/23, and posaconazole (1/23. Among the 23 centers, 3 reported that for allogenic transplants they changed the antifungal prophylactic in cases of graft versus host disease (GVHD, and 12 of the 23 centers reported that they changed the antifungal prophylactic in case of nearby construction. All 23 centers performed secondary prophylaxis. Conclusion: Antifungal prophylaxis for hematopoetic SCT patients was the standard protocol in the 23 centers included in the study, usually with such azoles as F. The introduction of posaconazole in Turkey and the potential approval of voriconazole for antifungal prophylaxis will

  5. Research Utilization in Social Work Education.

    Science.gov (United States)

    Briar, Scott, Ed.; And Others

    The Project on Research Utilization in Social Work Education established in 1976 is described. There are eight chapters to the report. Chapter 1 describes the project. The broad goals of the project were to: (1) analyze the dynamics of research utilization in social work; (2) identify the obstacles to research utilization, especially those that…

  6. Health utilities of hypertensive patients in Vietnam

    NARCIS (Netherlands)

    Nguyen, T.P.; Postma, M.J.; Veninga, Catharina

    2015-01-01

    Objectives: With a lack of an essential evidence on utilities to support cost-effectiveness analysis of hypertension management in Vietnam, we aimed to gather data on health utilities for hypertensive patients and identify predictors of utility. Methods: Hypertensive patients, from 40 to 80 years ol

  7. 75 FR 4098 - Utility Allowance Adjustments

    Science.gov (United States)

    2010-01-26

    ... URBAN DEVELOPMENT Utility Allowance Adjustments AGENCY: Office of the Chief Information Officer, HUD... are required to advise the Secretary of the need for and request of a new utility allowance for... whether the information will have practical utility; (2) Evaluate the accuracy of the agency's estimate...

  8. 25 CFR 700.105 - Utility charges.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Utility charges. 700.105 Section 700.105 Indians THE OFFICE OF NAVAJO AND HOPI INDIAN RELOCATION COMMISSION OPERATIONS AND RELOCATION PROCEDURES General Policies and Instructions Definitions § 700.105 Utility charges. Utility charges means the cost for...

  9. 10 CFR 34.71 - Utilization logs.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Utilization logs. 34.71 Section 34.71 Energy NUCLEAR... RADIOGRAPHIC OPERATIONS Recordkeeping Requirements § 34.71 Utilization logs. (a) Each licensee shall maintain utilization logs showing for each sealed source the following information: (1) A description, including...

  10. 49 CFR 218.22 - Utility employee.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Utility employee. 218.22 Section 218.22... employee. (a) A utility employee shall be subject to the Hours of Service Act, and the requirements for... parts 217, 219, and 228 of this chapter. (b) A utility employee shall perform service as a member...

  11. 45 CFR 12.12 - Utilization.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Utilization. 12.12 Section 12.12 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION DISPOSAL AND UTILIZATION OF SURPLUS REAL PROPERTY FOR PUBLIC HEALTH PURPOSES § 12.12 Utilization. (a) Where property or any portion thereof is not...

  12. 10 CFR 766.101 - Data utilization.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Data utilization. 766.101 Section 766.101 Energy DEPARTMENT OF ENERGY URANIUM ENRICHMENT DECONTAMINATION AND DECOMMISSIONING FUND; PROCEDURES FOR SPECIAL ASSESSMENT OF DOMESTIC UTILITIES Procedures for Special Assessment § 766.101 Data utilization. DOE shall use...

  13. 45 CFR 650.11 - Utilization reports.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Utilization reports. 650.11 Section 650.11 Public... Utilization reports. Paragraph (h) of the standard Patent Rights clause set forth in § 650.4 obliges grantees “to submit on request periodic reports no more frequently than annually on the utilization of a...

  14. Trends in Utility Green Pricing Programs (2005)

    Energy Technology Data Exchange (ETDEWEB)

    Bird, L.; Brown, E.

    2006-10-01

    This report presents year-end 2005 data on utility green pricing programs, and examines trends in consumer response and program implementation over time. The data in this report, which were obtained via a questionnaire distributed to utility green pricing program managers, can be used by utilities to benchmark the success of their green power programs.

  15. Celss nutrition system utilizing snails

    Science.gov (United States)

    Midorikawa, Y.; Fujii, T.; Ohira, A.; Nitta, K.

    At the 40th IAF Congress in Malaga, a nutrition system for a lunar base CELSS was presented. A lunar base with a total of eight crew members was envisaged. In this paper, four species of plants—rice, soybean, lettuce and strawberry—were introduced to the system. These plants were sufficient to satisfy fundamental nutritional needs of the crew members. The supply of nutrition from plants and the human nutritional requirements could almost be balanced. Our study revealed that the necessary plant cultivation area per crew member would be nearly 40 m 3 in the lunar base. The sources of nutrition considered in the study were energy, sugar, fat, amino acids, inorganic salt and vitamins; however, calcium, vitamin B 2, vitamin A and sodium were found to be lacking. Therefore, a subsystem to supply these elements is of considerable value. In this paper, we report on a study for breeding snails and utilizing meat as food. Nutrients supplied from snails are shown to compensate for the abovementioned lacking elements. We evaluate the snail breeder and the associated food supply system as a subsystem of closed ecological life support system.

  16. Fuel Utilization and Environment Pollution

    Directory of Open Access Journals (Sweden)

    B. S. Soroka

    2007-01-01

    Full Text Available An influence of utilization of various fuel types on the environment pollution has been analyzed taking into account the state and forecast of changes in consumption structure of primary energy in the world.The regional peculiarities of the environment impact have been studied methodically (regarding the Ukraine as an example: distribution of the harmful effluents has been considered in various regions of the country and inter-relations of some branches of national economy and industry with the atmosphere pollution have been examined.The CO2 effluent distribution within the European regions has been considered as the main greenhouse gas. It has been stated that the difference of the specific CO2 effluent yield per unit of GDP makes more than an order by value between some European countries.This index becomes higher if specific GDP of the country concerned is lower and portion of extractive industries, metallurgical and fuel-power complexes is higher in the country’s economy.

  17. Domestic utility attitudes toward foreign uranium supply

    Energy Technology Data Exchange (ETDEWEB)

    1981-06-01

    The current embargo on the enrichment of foreign-origin uranium for use in domestic utilization facilities is scheduled to be removed in 1984. The pending removal of this embargo, complicated by a depressed worldwide market for uranium, has prompted consideration of a new or extended embargo within the US Government. As part of its on-going data collection activities, Nuclear Resources International (NRI) has surveyed 50 domestic utility/utility holding companies (representing 60 lead operator-utilities) on their foreign uranium purchase strategies and intentions. The most recent survey was conducted in early May 1981. A number of qualitative observations were made during the course of the survey. The major observations are: domestic utility views toward foreign uranium purchase are dynamic; all but three utilities had some considered foreign purchase strategy; some utilities have problems with buying foreign uranium from particular countries; an inducement is often required by some utilities to buy foreign uranium; opinions varied among utilities concerning the viability of the domestic uranium industry; and many utilities could have foreign uranium fed through their domestic uranium contracts (indirect purchases). The above observations are expanded in the final section of the report. However, it should be noted that two of the observations are particularly important and should be seriously considered in formulation of foreign uranium import restrictions. These important observations are the dynamic nature of the subject matter and the potentially large and imbalanced effect the indirect purchases could have on utility foreign uranium procurement.

  18. [A medical-pharmaceutical partnership model as a contributor to the success in conditioning regimen for allogenic hematopoietic stem cell transplantation in adults: a cross-reflection on our organizations].

    Science.gov (United States)

    Bourget, Philippe; Falaschi, Ludivine; Suarez, Felipe; Galland, Valérie; Blot, Dominique; Trompette, Caroline; Sibon, David; Fontbrune, Flore Sicre de; Merlette, Christophe; Vidal, Fabrice; Corriol, Odile; Giraud, Bérénice; Broissand, Christine; Clement, Rozenn; Hermine, Olivier

    2012-06-01

    Allogeneic hematopoietic stem-cell transplant (allo-SCT) remains the only cure for many hematological malignancies and some benign and congenital diseases. Busulfan, proposed in its injectable form, has quickly become a mainstay of pharmacological and myeloablative (or non-myeloablative) conditioning. This is following the outbreak in 2010 of a multicenter international clinical phase II trial, we tested the robustness and reliability of our organization in a complex model of organization and multifactorial partnership. In this type "BuCy2" protocol based on a classical treatment duration of 4 consecutive days, the administration of IV busulfan is given in one single daily infusion instead of the conventional 16 infusions, while keeping the same total dose. Under these conditions, the treatment is totally secured using a therapeutic drug monitoring of busulfan, applied in real-time. The process is technically complex and requires the very close cooperation of the teams involved. A strength, weakness, opportunity and threat (SWOT) analysis has been constructed; it fully supports continuous quality improvement to the triple benefit of the nursing chain, the patients and their environment. Several critical points were identified and corrected. The experiment strongly contributes to the safety and security of the medication circuit at the hospital and, improves the performance of allo-SCT. It also contributes to the protection of all actors in the health field and their working environment via a well-functioning quality management system.

  19. Fly ash quality and utilization

    Energy Technology Data Exchange (ETDEWEB)

    Barta, L.E.; Lachner, L.; Wenzel, G.B. [Inst. for Energy, Budapest (Hungary); Beer, M.J. [Massachusetts Inst. of Technology, Cambridge, MA (United States)

    1995-12-01

    The quality of fly ash is of considerable importance to fly ash utilizers. The fly ash puzzolanic activity is one of the most important properties that determines the role of fly ash as a binding agent in the cementing process. The puzzolanic activity, however is a function of fly ash particle size and chemical composition. These parameters are closely related to the process of fly ash formation in pulverized coal fired furnaces. In turn, it is essential to understand the transformation of mineral matter during coal combustion. Due to the particle-to-particle variation of coal properties and the random coalescence of mineral particles, the properties of fly ash particles e.g. size, SiO{sub 2} content, viscosity can change considerably from particle to particle. These variations can be described by the use of the probability theory. Since the mean values of these randomly changing parameters are not sufficient to describe the behavior of individual fly ash particles during the formation of concrete, therefore it is necessary to investigate the distribution of these variables. Examples of these variations were examined by the Computer Controlled Scanning Electron Microscopy (CCSEM) for particle size and chemical composition for Texas lignite and Eagel Butte mineral matter and fly ash. The effect of combustion on the variations of these properties for both the fly ash and mineral matter were studied by using a laminar flow reactor. It is shown in our paper, that there are significant variations (about 40-50% around the mean values) of the above-listed properties for both coal samples. By comparing the particle size and chemical composition distributions of the mineral matter and fly ash, it was possible to conclude that for the Texas lignite mineral matter, the combustion did not effect significantly the distribution of these properties, however, for the Eagel Butte coal the combustion had a major impact on these mineral matter parameters.

  20. [Utilities: a solution of a decision problem?].

    Science.gov (United States)

    Koller, Michael; Ohmann, Christian; Lorenz, Wilfried

    2008-01-01

    Utility is a concept that originates from utilitarianism, a highly influential philosophical school in the Anglo-American world. The cornerstone of utilitarianism is the principle of maximum happiness or utility. In the medical sciences, this utility approach has been adopted and developed within the field of medical decision making. On an operational level, utility is the evaluation of a health state or an outcome on a one-dimensional scale ranging from 0 (death) to 1 (perfect health). By adding the concept of expectancy, the graphic representation of both concepts in a decision tree results in the specification of expected utilities and helps to resolve complex medical decision problems. Criticism of the utility approach relates to the rational perspective on humans (which is rejected by a considerable fraction of research in psychology) and to the artificial methods used in the evaluation of utility, such as Standard Gamble or Time Trade Off. These may well be the reason why the utility approach has never been accepted in Germany. Nevertheless, innovative concepts for defining goals in health care are urgently required, as the current debate in Germany on "Nutzen" (interestingly translated as 'benefit' instead of as 'utility') and integrated outcome models indicates. It remains to be seen whether this discussion will lead to a re-evaluation of the utility approach.

  1. Utility-Interconnected Photovoltaic Systems: Evaluating the Rationale for the Utility-Accessible External Disconnect Switch

    Energy Technology Data Exchange (ETDEWEB)

    Coddington, M.; Margolis, R.M.; Aabakken, J.

    2008-01-01

    The utility-accessible alternating current (AC) external disconnect switch (EDS) for distributed generators, including photovoltaic (PV) systems, is a hardware feature that allows a utility?s employees to manually disconnect a customer-owned generator from the electricity grid. This paper examines the utility-accessible EDS debate in the context of utility-interactive PV systems for residential and small commercial installations. It also evaluates the rationale for EDS requirements.

  2. Heat utilization (2); Netsuriyo (2)

    Energy Technology Data Exchange (ETDEWEB)

    Akizawa, Jun [Tokyo University of Agriculture and Tecnology, Tokyo (Japan)

    1999-01-31

    (102) The application of the carbon dioxide separation and collection system using CPC to the thermal power plant. (103) The effect of the scattered light on collection of heat of solar pond. (104) The development of the Basin- multiple-effect compound type solar heat distiller. (Production and performance test of the small plant.) (105) On the plan of the new-model solar heat engine. (106) The performance prediction of solar power system using Stirling engine. (Part 2 The case in which the divided condenser was used.) (107) The trial manufacture of the sun cooker. It was announced and was made of 6 from various regions in this session on the heat utilization. On the multiple-effect compound type solar heat distiller, the comment that the feasibility could be expected from the simple structure was made. And, the question on system operation of allocation of the distillation quantity, etc. was actively made. On 2 of plan of the new-model solar heat engine and trial manufacture of the sun cooker, it was not possible that the publicator came for the aged to Okinawa, and instead, it became an announcement by tape and OHP blown in self. Though it was the form which there was no in the convention, it could be heard of that it is major field. It was thought, because there was some an announcement on the Stirling engine in the this session, place be able to. And, photograph and experimental result of the prototype are also included for the announcement of the sun cooker and want to desire the opportunities which hear the direct announcement. It wants to be thankful for hardship Mr.Naito the Science and Technology Agency National Aerospace Laboratory that it carried tape and OHP and assisted the announcement. The biomass. (108) The measurement approach of the environment resuscitation acceleration effect. (109) The basic research on the biogas storage by the clathration. The behavior of the carbon dioxide in the clathrate generation. (111) The solar thermal application

  3. Stochastic Dominance under the Nonlinear Expected Utilities

    Directory of Open Access Journals (Sweden)

    Xinling Xiao

    2014-01-01

    Full Text Available In 1947, von Neumann and Morgenstern introduced the well-known expected utility and the related axiomatic system (see von Neumann and Morgenstern (1953. It is widely used in economics, for example, financial economics. But the well-known Allais paradox (see Allais (1979 shows that the linear expected utility has some limitations sometimes. Because of this, Peng proposed a concept of nonlinear expected utility (see Peng (2005. In this paper we propose a concept of stochastic dominance under the nonlinear expected utilities. We give sufficient conditions on which a random choice X stochastically dominates a random choice Y under the nonlinear expected utilities. We also provide sufficient conditions on which a random choice X strictly stochastically dominates a random choice Y under the sublinear expected utilities.

  4. British Columbia Utilities Commission 1998 annual report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-06-01

    The BC Utilities Commission is an independent regulatory agency of the provincial government that operates under the Utilities Commission Act. The Commission's main responsibility is the regulation of the energy utilities under its jurisdiction to ensure that rates charged for energy are fair, just and reasonable, and that utility operations provide safe, adequate and secure service to their clients. It approves the construction of new facilities planned by utilities and their issuance of securities. The Commission's function is quasi-judical and its Decisions and Orders may be appealed to the Court of Appeal on questions of law or jurisdiction. It participates in the review of utility and energy projects under the Environmental Assessment Act. It also reviews, evaluates, and reports on energy related matters referred to it by Cabinet. This review usually involves public hearings followed by a decision or a report and recommendations to the Lieutenant Governor in Council.

  5. British Columbia Utilities Commission 1998 annual report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-06-01

    The BC Utilities Commission is an independent regulatory agency of the provincial government that operates under the Utilities Commission Act. The Commission`s main responsibility is the regulation of the energy utilities under its jurisdiction to ensure that rates charged for energy are fair, just and reasonable, and that utility operations provide safe, adequate and secure service to their clients. It approves the construction of new facilities planned by utilities and their issuance of securities. The Commission`s function is quasi-judical and its Decisions and Orders may be appealed to the Court of Appeal on questions of law or jurisdiction. It participates in the review of utility and energy projects under the Environmental Assessment Act. It also reviews, evaluates, and reports on energy related matters referred to it by Cabinet. This review usually involves public hearings followed by a decision or a report and recommendations to the Lieutenant Governor in Council.

  6. Trends in Utility Green Pricing Programs (2006)

    Energy Technology Data Exchange (ETDEWEB)

    Bird, L.; Kaiser, M.

    2007-10-01

    In the early 1990s, only a handful of utilities offered their customers a choice of purchasing electricity generated from renewable energy sources. Today, more than 750 utilities--or about 25% of all utilities nationally--provide their customers a "green power" option. Through these programs, more than 70 million customers have the ability to purchase renewable energy to meet some portion or all of their electricity needs--or make contributions to support the development of renewable energy resources. Typically, customers pay a premium above standard electricity rates for this service. This report presents year-end 2006 data on utility green pricing programs, and examines trends in consumer response and program implementation over time. The data in this report, which were obtained via a questionnaire distributed to utility green pricing program managers, can be used by utilities to benchmark the success of their green power programs.

  7. Utilization-focused evaluation for agricultural innovation

    OpenAIRE

    Patton, Michael Quinn; Horton, Douglas

    2008-01-01

    Utilization-focused evaluation (UFE) is based on the principle that an evaluation should be judged by its utility. So no matter how technically sound and methodologically elegant, an evaluation is not truly a good evaluation unless the findings are used. UFE is a framework for enhancing the likelihood that evaluation findings will be used and lessons will be learnt from the evaluation process. This Brief, based on the book Utilization-focused evaluation, introduces this approach to evaluation...

  8. Lessons Learned: Community Solar for Municipal Utilities

    Energy Technology Data Exchange (ETDEWEB)

    2016-12-01

    This report outlines the work that STAT has completed, discusses the range of approaches utilities are taking, and highlights several challenges municipal utilities face in deciding whether and how to pursue community solar. As this report shows, there is no 'silver bullet' in terms of municipal utility community solar design or implementation - programs vary significantly and are highly dependent on localized contexts.

  9. Capacity and Capacity Utilization in Fishing Industries

    OpenAIRE

    Kirkley, James E; Squires, Dale

    1999-01-01

    Excess capacity of fishing fleets is one of the most pressing problems facing the world's fisheries and the sustainable harvesting of resource stocks. Considerable confusion persists over the definition and measurement of capacity and capacity utilization in fishing. Fishing capacity and capacity utilization, rather than capital (or effort) utilization, provide the appropriate framework. This paper provides both technological-economic and economic definitions of capacity and excess capacity i...

  10. Utility FGD Survey, January--December 1989

    Energy Technology Data Exchange (ETDEWEB)

    Hance, S.L.; McKibben, R.S.; Jones, F.M. (IT Corp., Cincinnati, OH (United States))

    1992-03-01

    The Utility flue gas desulfurization (FGD) Survey report, which is generated by a computerized data base management system, represents a survey of operational and planned domestic utility flue gas desulfurization (FGD) systems. It summarizes information contributed by the utility industry, system and equipment suppliers, system designers, research organizations, and regulatory agencies. The data cover system design, fuel characteristics, operating history, and actual system performance. Also included is a unit-by-unit discussion of problems and solutions associated with the boilers, scrubbers, and FGD systems. The development status (operational, under construction, or in the planning stages), system supplier, process, waste disposal practice, and regulatory class are tabulated alphabetically by utility company.

  11. Dynamic decision making without expected utility

    DEFF Research Database (Denmark)

    Nielsen, Thomas Dyhre; Jaffray, Jean-Yves

    2006-01-01

    Non-expected utility theories, such as rank dependent utility (RDU) theory, have been proposed as alternative models to EU theory in decision making under risk. These models do not share the separability property of expected utility theory. This implies that, in a decision tree, if the reduction...... maker’s discordant goals at the different decision nodes. Relative to the computations involved in the standard expected utility evaluation of a decision problem, the main computational increase is due to the identification of non-dominated strategies by linear programming. A simulation, using the rank...

  12. Utility FGD Survey, January--December 1989

    Energy Technology Data Exchange (ETDEWEB)

    Hance, S.L.; McKibben, R.S.; Jones, F.M. (IT Corp., Cincinnati, OH (United States))

    1992-03-01

    The Utility flue gas desulfurization (FGD) Survey report, which is generated by a computerized data base management system, represents a survey of operational and planned domestic utility flue gas desulfurization (FGD) systems. It summarizes information contributed by the utility industry, system and equipment suppliers, system designers, research organizations, and regulatory agencies. The data cover system design, fuel characteristics, operating history, and actual system performance. Also included is a unit-by-unit discussion of problems and solutions associated with the boilers, scrubbers, and FGD systems. The development status (operational, under construction, or in the planning stages), system supplier, process, waste disposal practice, and regulatory class are tabulated alphabetically by utility company.

  13. Mining High Utility Itemsets with Regular Occurrence

    Directory of Open Access Journals (Sweden)

    Komate Amphawan

    2016-09-01

    Full Text Available High utility itemset mining (HUIM plays an important role in the data mining community and in a wide range of applications. For example, in retail business it is used for finding sets of sold products that give high profit, low cost, etc. These itemsets can help improve marketing strategies, make promotions/ advertisements, etc. However, since HUIM only considers utility values of items/itemsets, it may not be sufficient to observe product-buying behavior of customers such as information related to “regular purchases of sets of products having a high profit margin”. To address this issue, the occurrence behavior of itemsets (in the term of regularity simultaneously with their utility values was investigated. Then, the problem of mining high utility itemsets with regular occurrence (MHUIR to find sets of co-occurrence items with high utility values and regular occurrence in a database was considered. An efficient single-pass algorithm, called MHUIRA, was introduced. A new modified utility-list structure, called NUL, was designed to efficiently maintain utility values and occurrence information and to increase the efficiency of computing the utility of itemsets. Experimental studies on real and synthetic datasets and complexity analyses are provided to show the efficiency of MHUIRA combined with NUL in terms of time and space usage for mining interesting itemsets based on regularity and utility constraints.

  14. The predictive validity of prospect theory versus expected utility in health utility measurement.

    Science.gov (United States)

    Abellan-Perpiñan, Jose Maria; Bleichrodt, Han; Pinto-Prades, Jose Luis

    2009-12-01

    Most health care evaluations today still assume expected utility even though the descriptive deficiencies of expected utility are well known. Prospect theory is the dominant descriptive alternative for expected utility. This paper tests whether prospect theory leads to better health evaluations than expected utility. The approach is purely descriptive: we explore how simple measurements together with prospect theory and expected utility predict choices and rankings between more complex stimuli. For decisions involving risk prospect theory is significantly more consistent with rankings and choices than expected utility. This conclusion no longer holds when we use prospect theory utilities and expected utilities to predict intertemporal decisions. The latter finding cautions against the common assumption in health economics that health state utilities are transferable across decision contexts. Our results suggest that the standard gamble and algorithms based on, should not be used to value health.

  15. Back to Bentham? Explorations of Experienced Utility

    NARCIS (Netherlands)

    D. Kahneman (Daniel); P.P. Wakker (Peter); R.K. Sarin (Rakesh)

    1997-01-01

    textabstractTwo core meanings of “utility” are distinguished. “Decision utility” is the weight of an outcome in a decision. “Experienced utility” is hedonic quality, as in Bentham’s usage. Experienced utility can be reported in real time (instant utility), or in retrospective evaluations of past

  16. Towards Utility in Reviews of Multivocal Literatures.

    Science.gov (United States)

    Patton, Michael Quinn

    1991-01-01

    In program evaluation and policy analyses, utility supplants rigor as the first and most important criterion in judging literature reviews. Although R. T. Ogawa and B. Malen emphasize rigor, a utilization-focused evaluation emphasizes purpose and audience, both of which affect the conduct of a multivocal literature review. (SLD)

  17. Public utility regulation and national energy policy

    Energy Technology Data Exchange (ETDEWEB)

    Navarro, P.

    1980-09-01

    The linkage between Public Utility Commission (PUC) regulation, the deteriorating financial health of the electric utility industry, and implementation of national energy policy, particularly the reduction of foreign petroleum consumption in the utility sector is examined. The role of the Nation's utilities in the pursuit of national energy policy goals and postulates a linkage between PUC regulation, the poor financial health of the utility industry, and the current and prospective failure to displace foreign petroleum in the utility sector is discussed. A brief history of PUC regulation is provided. The concept of regulatory climate and how the financial community has developed a system of ranking regulatory climate in the various State jurisdictions are explained. The existing evidence on the hypothesis that the cost of capital to a utility increases and its availability is reduced as regulatory climate grows more unfavorable from an investor's point of view is analyzed. The implications of this cost of capital effect on the electric utilities and collaterally on national energy policy and electric ratepayers are explained. Finally various State, regional and Federal regulatory responses to problems associated with PUC regulation are examined.

  18. Marginal Utility and Convex Indifference Curves.

    Science.gov (United States)

    Jackson, A.A.

    1981-01-01

    Reviews discussion of the relationship between marginal utility and indifference curves which has been presented in recent issues of "Economics." Concludes that indifference analysis does not embody the assumptions of marginal utility theory and that there is no simple relationship between these concepts that does not entail unacceptable…

  19. 24 CFR 5.632 - Utility reimbursements.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Utility reimbursements. 5.632... Section 8 Project-Based Assistance Family Payment § 5.632 Utility reimbursements. (a) Applicability. This...); (2) A public housing family paying an income-based rent (see § 960.253 of this title)....

  20. Subjective Expected Utility Theory with "Small Worlds"

    DEFF Research Database (Denmark)

    Gyntelberg, Jacob; Hansen, Frank

    which is a more general construction than a state space. We retain preference axioms similar in spirit to the Savage axioms and obtain, without abandoning linearity of expectations, a subjective expected utility theory which allows for an intuitive distinction between risk and uncertainty. We also...... obtain separation of subjective probability and utility as in the state space models....

  1. Working memory management and predicted utility.

    Science.gov (United States)

    Chatham, Christopher H; Badre, David

    2013-01-01

    Given the limited capacity of working memory (WM), its resources should be allocated strategically. One strategy is filtering, whereby access to WM is granted preferentially to items with the greatest utility. However, reallocation of WM resources might be required if the utility of maintained information subsequently declines. Here, we present behavioral, computational, and neuroimaging evidence that human participants track changes in the predicted utility of information in WM. First, participants demonstrated behavioral costs when the utility of items already maintained in WM declined and resources should be reallocated. An adapted Q-learning model indicated that these costs scaled with the historical utility of individual items. Finally, model-based neuroimaging demonstrated that frontal cortex tracked the utility of items to be maintained in WM, whereas ventral striatum tracked changes in the utility of items maintained in WM to the degree that these items are no longer useful. Our findings suggest that frontostriatal mechanisms track the utility of information in WM, and that these dynamics may predict delays in the removal of information from WM.

  2. Clinical Utility and "DSM-V"

    Science.gov (United States)

    Mullins-Sweatt, Stephanie N.; Widiger, Thomas A.

    2009-01-01

    The construction of the American Psychiatric Association's diagnostic manual has been guided primarily by concerns of construct validity rather than of clinical utility, despite claims by its authors that the highest priority has in fact been clinical utility. The purpose of this article was to further articulate the concept and importance of…

  3. The Utility Battery Storage Systems Program Overview

    Energy Technology Data Exchange (ETDEWEB)

    1994-11-01

    Utility battery energy storage allows a utility or customer to store electrical energy for dispatch at a time when its use is more economical, strategic, or efficient. The UBS program sponsors systems analyses, technology development of subsystems and systems integration, laboratory and field evaluation, and industry outreach. Achievements and planned activities in each area are discussed.

  4. The homogeneous marginal utility of income assumption

    NARCIS (Netherlands)

    Demuynck, T.

    2015-01-01

    We develop a test to verify if every agent from a population of heterogeneous consumers has the same marginal utility of income function. This homogeneous marginal utility of income assumption is often (implicitly) used in applied demand studies because it has nice aggregation properties and facilit

  5. Continuous expected utility for arbitrary state spaces

    NARCIS (Netherlands)

    Wakker, P.P.

    1985-01-01

    Subjective expected utility maximization with continuous utility is characterized, extending the result of Wakker (1984, Journal of Mathematical Psychology) to infinite state spaces. In Savage (1954, The Foundations of Statistics) the main restriction, P6, requires structure for the state space, e.g

  6. 41 CFR 109-28.5006 - Utilization.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Utilization. 109-28.5006 Section 109-28.5006 Public Contracts and Property Management Federal Property Management Regulations... AND DISTRIBUTION 28.50-Management of Equipment Held for Future Projects § 109-28.5006 Utilization. It...

  7. 41 CFR 101-30.403 - Utilization.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Utilization. 101-30.403 Section 101-30.403 Public Contracts and Property Management Federal Property Management Regulations System... Federal Catalog System § 101-30.403 Utilization. On and after the established date for completion of...

  8. 47 CFR 101.521 - Spectrum utilization.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Spectrum utilization. 101.521 Section 101.521 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES 24 GHz Service and Digital Electronic Message Service § 101.521 Spectrum utilization. All...

  9. Back to Bentham? Explorations of Experienced Utility

    NARCIS (Netherlands)

    D. Kahneman (Daniel); P.P. Wakker (Peter); R.K. Sarin (Rakesh)

    1997-01-01

    textabstractTwo core meanings of “utility” are distinguished. “Decision utility” is the weight of an outcome in a decision. “Experienced utility” is hedonic quality, as in Bentham’s usage. Experienced utility can be reported in real time (instant utility), or in retrospective evaluations of past epi

  10. Benchmark Two-Good Utility Functions

    NARCIS (Netherlands)

    de Jaegher, K.

    Benchmark two-good utility functions involving a good with zero income elasticity and unit income elasticity are well known. This paper derives utility functions for the additional benchmark cases where one good has zero cross-price elasticity, unit own-price elasticity, and zero own price

  11. Benchmark Two-Good Utility Functions

    NARCIS (Netherlands)

    de Jaegher, K.

    2007-01-01

    Benchmark two-good utility functions involving a good with zero income elasticity and unit income elasticity are well known. This paper derives utility functions for the additional benchmark cases where one good has zero cross-price elasticity, unit own-price elasticity, and zero own price elasticit

  12. Photovoltaic utility/customer interface study

    Science.gov (United States)

    Eichler, C. H.; Hayes, T. P.; Matthews, M. M.; Wilraker, V. F.

    1980-12-01

    The technical, economic, and legal and regulatory issues of interconnecting small, privately-owned, on-site photovoltaic generating systems to an electric utility are addressed. Baseline residential, commercial and industrial class photovoltaic systems were developed. Technical issues of concern affecting this interconnection were identified and included fault protection, undervoltage protection, lamp flicker, revenue metering, loss of synchromism, electrical safety, prevention of backfeeding a de-energized utility feeder, effects of on-site generation on utility relaying schemes, effects of power conditioner harmonic distortion on the electric utility, system isolation, electromagnetic interference and site power factor as seen by the utility. Typical interconnection wiring diagrams were developed for interconnecting each class of baseline photovoltaic generating system.

  13. Risk and utility in portfolio optimization

    Science.gov (United States)

    Cohen, Morrel H.; Natoli, Vincent D.

    2003-06-01

    Modern portfolio theory (MPT) addresses the problem of determining the optimum allocation of investment resources among a set of candidate assets. In the original mean-variance approach of Markowitz, volatility is taken as a proxy for risk, conflating uncertainty with risk. There have been many subsequent attempts to alleviate that weakness which, typically, combine utility and risk. We present here a modification of MPT based on the inclusion of separate risk and utility criteria. We define risk as the probability of failure to meet a pre-established investment goal. We define utility as the expectation of a utility function with positive and decreasing marginal value as a function of yield. The emphasis throughout is on long investment horizons for which risk-free assets do not exist. Analytic results are presented for a Gaussian probability distribution. Risk-utility relations are explored via empirical stock-price data, and an illustrative portfolio is optimized using the empirical data.

  14. Trends in Utility Green Pricing Programs (2006)

    Energy Technology Data Exchange (ETDEWEB)

    Bird, Lori [National Renewable Energy Lab. (NREL), Golden, CO (United States); Kaiser, Marshall [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2007-10-01

    In the early 1990s, only a handful of utilities offered their customers a choice of purchasing electricity generated from renewable energy sources. Today, more than 750 utilities—or about 25% of all utilities nationally—provide their customers a “green power” option. Through these programs, more than 70 million customers have the ability to purchase renewable energy to meet some portion or all of their electricity needs—or make contributions to support the development of renewable energy resources. Typically, customers pay a premium above standard electricity rates for this service. This report presents year-end 2006 data on utility green pricing programs, and examines trends in consumer response and program implementation over time. The data in this report, which were obtained via a questionnaire distributed to utility green pricing program managers, can be used by utilities to benchmark the success of their green power programs.

  15. A Unified Derivation of Classical Subjective Expected Utility Models through Cardinal Utility

    NARCIS (Netherlands)

    Zank, H.; Wakker, P.P.

    1999-01-01

    Classical foundations of expected utility were provided by Ramsey, de Finetti, von Neumann & Morgenstern, Anscombe & Aumann, and others. These foundations describe preference conditions to capture the empirical content of expected utility. The assumed preference conditions, however, vary among the m

  16. Utilization of mining and mineral wastes

    Energy Technology Data Exchange (ETDEWEB)

    Park, Kyung Ho; Hong, Seung Woong; Choi, Young Yoon; Kim, Byung Gyu; Park, Je Shin [Korea Institute of Geology Mining and Materials, Taejon (Korea)

    1998-12-01

    Up to now, it is estimated that more than 50 million tons of mineral wastes have been generated mining industries and deposited on the land in Korea. Much of cultivated land and hilly areas have been occupied by this wastes, which cause pollution of the environment. Utilization of the mineral wastes is preferable to stabilization because full use would both eliminate the waste and broaden the mineral resource base. Therefore, the development of utilization techniques of mineral wastes is very important not only for improving the environment but also for resource conservation. In countries with high population and poor natural resources like Korea, the utilization of these wastes is essential to decrease the environmental problem and the secure the resources and the study on this field play a important part. Therefore, the objective of this study is to develop the utilization techniques of the mineral wastes. In first year's research, the contents and scope of this study are 1) Present condition and Field Survey on the mineral wastes with respect of their utilization, 2) Reviews of Current effects and research to utilize mineral wastes, 3) Characterization of mineral wastes and environmental test, 4) Evaluation and study on the utilization. (author). 67 refs., 25 tabs., 54 figs.

  17. Utilization of mining and mineral wastes

    Energy Technology Data Exchange (ETDEWEB)

    Park, Kyung Ho; Hong, Seung Woong; Choi, Young Yoon; Kim, Byung Gyu; Park, Je Shin [Korea Institute of Geology Mining and Materials, Taejon (Korea)

    1998-12-01

    Up to now, it is estimated that more than 50 million tons of mineral wastes have been generated mining industries and deposited on the land in Korea. Much of cultivated land and hilly areas have been occupied by this wastes, which cause pollution of the environment. Utilization of the mineral wastes is preferable to stabilization because full use would both eliminate the waste and broaden the mineral resource base. Therefore, the development of utilization techniques of mineral wastes is very important not only for improving the environment but also for resource conservation. In countries with high population and poor natural resources like Korea, the utilization of these wastes is essential to decrease the environmental problem and the secure the resources and the study on this field play a important part. Therefore, the objective of this study is to develop the utilization techniques of the mineral wastes. In first year's research, the contents and scope of this study are 1) Present condition and Field Survey on the mineral wastes with respect of their utilization, 2) Reviews of Current effects and research to utilize mineral wastes, 3) Characterization of mineral wastes and environmental test, 4) Evaluation and study on the utilization. (author). 67 refs., 25 tabs., 54 figs.

  18. Trends in Utility Green Pricing Programs (2004)

    Energy Technology Data Exchange (ETDEWEB)

    Bird, L.; Brown, E.

    2005-10-01

    In the early 1990s, only a handful of utilities offered their customers a choice of purchasing electricity generated from renewable energy sources. Today, nearly 600 utilities in regulated electricity markets--or almost 20% of all utilities nationally--provide their customers a "green power" option. Because some utilities offer programs in conjunction with cooperative associations or other publicly owned power entities, the number of distinct programs totals about 125. Through these programs, more than 40 million customers spanning 34 states have the ability to purchase renewable energy to meet some portion or all of their electricity needs--or make contributions to support the development of renewable energy resources. Typically, customers pay a premium above standard electricity rates for this service. This report presents year-end 2004 data on utility green pricing programs, and examines trends in consumer response and program implementation over time. The data in this report, which were obtained via a questionnaire distributed to utility green pricing program managers, can be used by utilities as benchmarks by which to gauge the success of their green power programs.

  19. A general classification of silicon utilizing organisms

    Science.gov (United States)

    Das, P.; Das, S.

    2010-12-01

    Silicon utilizing organisms may be defined as organisms with high silicon content (≥ 1% dry weight) and they can metabolize silicon with or without demonstrable silicon transporter genes (SIT) in them(Das,2010). Silicon is the second most abundant element in the lithosphere (27.70%) and it is as important as phosphorus and magnesium (0.03%) in the biota. Hydrated silica represents the second most abundant biogenic mineral after carbonate minerals. Silicon is accumulated and metabolized by some prokaryotes, and Si compounds can stimulate the growth of a range of fungi. It is well known that Si is essential for diatoms. In mammals, Si is considered an essential trace element, required in bone, cartilage and connective tissue formation, enzymatic activities and other metabolic processes. Silicon was suggested to act as a phosphoprotein effector in bone. In mammals, Si is also reported to positively influence the immune system and to be required for lymphocyte proliferation. The aqueous chemistry of Si is dominated by silicic acid at biological pH ranges. Monosilicic acid can form stable complexes with organic hydroxy-containing molecules . Biosilica also has been identified associated with various biomolecules including proteins and carbohydrates. There are main seven groups of silicon utilizing organisms belonging to Gram positive bacteria, algae, protozoa, sponges, fungi, lichens, and monocotyledon plants. In each group again all the members are not silicon utilizing organisms, thus selective members in each group are further classified depending their degree of silicon utilization. Important silicon utilizing bacteria are Mycobacteria, Nocardia, Streptomyces, Staphylococcus, Bacillus, Lactobacillus spp. etc., Important silicon utilizing algae are Centrobacillariophyceae, Pennatibacillariophyceae and Chrysophyceae. Many protozoa belonging to Heterokonta, Choanoflagellida, Actinopoda are well known silicon utilizing microorganisms. Hexactinellida ( glass sponges

  20. Utility Tax Avoidance Program in Germany

    Science.gov (United States)

    2010-09-29

    Statistical Projections - Utility Costs And Taxes (Values Presented in Euros and Dollars) Electric Point Estimate Lower Bound U pper Bound Euros...Estimate Lower Bound U pper Bound Euros Dollars Euros Dollars Euros Dollars Iolal Utility Cost E1,464,848 $2, 101,526 E1,094,587 $1,570,335 E1,835,109...298,367 348,671 500,216 Water Point Estimate Lower Bound U pper Bound Euros Dollars Euros Dollars Euros Dollars Iolal Utility Cost E166,296 $238,574

  1. Shareholders, creditors approve utility reorganization plan

    Energy Technology Data Exchange (ETDEWEB)

    1990-04-12

    Shareholders and all classes of secured creditors of Public Service Company of New Hampshire voted overwhelmingly last month to approve Northeast Utilities' Chapter 11 reorganization plan for PSNH, the utility announced. PSNH filed for bankruptcy protection in January 1988. Under the reorganization plan, Connecticut-based NU would acquire the utility for $2.3 billion. While PSNH's preferred and common stockholders voted to accept the proposal, holders of warrants to purchase PSNH common stock rejected the plan. Except for the votes of a group of independent power producers, PSNH's unsecured creditors also voted to accept the plan.

  2. The Service Utility Model in Service Management

    Institute of Scientific and Technical Information of China (English)

    LI Yan; ZHOU Wen-an; SONG Jun-de

    2005-01-01

    Aiming to provide a measurable service Quality of Service (QoS) evaluating method for service inventory management, this paper proposes a new mobile Service Utility Model (SUM), considers the service and business layer elements into the service utility influence profile, and proposes an self-adaptive service inventory management algorithm as a QoS control scheme based on SUM. It can be concluded from the simulation result that the service inventory utility can be fully reflected by SUM and the whole system efficiency is greatly increased by using SUM as the adaptive rule.

  3. Utility FGD survey, January--December 1989

    Energy Technology Data Exchange (ETDEWEB)

    Hance, S.L.; McKibben, R.S.; Jones, F.M. (IT Corp., Cincinnati, OH (United States))

    1992-03-01

    This is Volume 2 part 2, of the Utility flue gas desulfurization (FGD) Survey report, which is generated by a computerized data base management system, represents a survey of operational and planned domestic utility flue gas desulfurization (FGD) systems. It summarizes information contributed by the utility industry, system and equipment suppliers, system designers, research organizations, and regulatory agencies. The data cover system design, fuel characteristics, operating history, and actual system performance. Also included is a unit-by-unit discussion of problems and solutions associated with the boilers, scrubbers, and FGD systems. This volume particularly contains basic design and performance data.

  4. Recent development of vibration utilization engineering

    Institute of Scientific and Technical Information of China (English)

    Bangchun WEN

    2008-01-01

    The utilization of vibration and wave, which was developed during the latter half of the 20th century, is one of the most valueable technology applications and has been rapidly developing recently [1-10]. Because the technique is closely associated with industry and agricul-ture, it can create huge social and economical benefits and provide excellent services for society. Thus, due to its necessity in industry and daily life, extensive research has been devoted to vibration utillization engineering. In this paper, vibration utilization is classified into linear or non-linear vibrations, waves, and electric-magnetic oscilla-tions. Their phenomena, patterns, and applications in nature and society are introduced. Some research results about vibration utilization engineering are described.

  5. Knee System Utilizing Personalized Solutions Instrumentation

    Science.gov (United States)

    ATTUNE® Knee System utilizing the TRUMATCH® Personalized Solutions Instrumentation Click Here to view the BroadcastMed, Inc. Privacy Policy and Legal Notice © 2017 BroadcastMed, Inc. All rights reserved.

  6. What utilities should expect from competitive intelligence

    Energy Technology Data Exchange (ETDEWEB)

    Fuld, L.M.; Borska, D.L. [Fuld & Company, Cambridge, MA (United States)

    1995-03-01

    Electric utilities are informationally dysfunctional. In a survey of electric utility managers, we found that while employees may possess the necessary information for decision-making, they may not understand how the information is used, why it is important, or who needs to know it. Utility managers feel that their organizations suffer from intelligence deficits in the following areas: (1) Customer Retention-Customer (rather than competitor) intelligence is desparately needed, (2) Competitor Costs-As prices drive markets, utilities must learn how competitors use the technology to gain a cost advantage, and (3) Market Savvy-Recognizing threats means more that just crunching the numbers. It means converting raw data into a strategy that will expose a competitor`s weakness. The complex economics will require companies to apply all types of intelligence to solve competitive problems. This coherent approach requires changes in the way both management and the organization handle vital intelligence.

  7. Utility FGD survey, Janurary--December 1988

    Energy Technology Data Exchange (ETDEWEB)

    Hance, S.L.; McKibben, R.S.; Jones, F.M. (IT Corp., Cincinnati, OH (United States))

    1991-09-01

    The Utility FGD Survey report, which is generated by a computerized data base management system, represents a survey of operational and planned domestic utility flue gas desulfurization (FGD) systems. It summarizes information contributed by the utility industry, system and equipment suppliers, system designers, research organizations, and regulatory agencies. The data cover system design, fuel characteristics, operating history, and actual system performance. Also included is a unit-by-unit discussion of problems and solutions associated with the boilers, scrubbers, and FGD systems. The development status (operational, under construction, or in the planning stages), system supplier, process, waste disposal practice, and regulatory class are tabulated alphabetically by utility company. Simplified process flow diagrams of FGD systems, definitions, and a glossary of terms are attached to the report. Current data for domestic FGD systems show systems in operation, systems under construction, and systems planned. The current total FGD-controlled capacity in the United States is 67,091 MW. 2 figs., 9 tabs.

  8. Utility FGD survey, January--December 1988

    Energy Technology Data Exchange (ETDEWEB)

    Hance, S.L.; McKibben, R.S.; Jones, F.M. (IT Corp., Cincinnati, OH (United States))

    1991-09-01

    The Utility FGD Survey report, which is generated by a computerized data base management system, represents a survey of operational and planned domestic utility flue gas desulfurization (FGD) systems. It summarizes information contributed by the utility industry, system and equipment suppliers, system designers, research organizations, and regulatory agencies. The data cover system design, fuel characteristics, operating history, and actual system performance. Also included is a unit-by-unit discussion of problems and solutions associated with the boilers, scrubbers, and FGD systems. The development status (operational, under construction, or in the planning stages), system supplier, process, waste disposal practice, and regulatory class are tabulated alphabetically by utility company. Simplified process flow diagrams of FGD systems, definitions, and a glossary of terms are attached to the report. Current data for domestic FGD systems show systems in operation, systems under construction, and systems planned. The current total FGD-controlled capacity in the United States is 67,091 MW.

  9. Utility FGD survey, January--December 1988

    Energy Technology Data Exchange (ETDEWEB)

    Hance, S.L.; McKibben, R.S.; Jones, F.M. (IT Corp., Cincinnati, OH (United States))

    1991-09-01

    The Utility FGD Survey report, which is generated by a computerized data base management system, represents a survey of operational and planned domestic utility flue gas desulfurization (FGD) systems. It summarizes information contributed by the utility industry, system and equipment suppliers, systems designers, research organizations, and regulatory agencies. The data cover system design, fuel characteristics, operating history, and actual system performance. Also included is a unit-by-unit discussion of problems and solutions associated with the boilers, scrubbers, and FGD systems. The development status (operational, under construction, or in the planning stages), system supplier, process, waste disposal practice, and regulatory class are tabulated alphabetically by utility company. Simplified process flow diagrams of FGD systems, definitions, and a glossary of terms are attached to the report. Current data for domestic FGD systems show systems in operation, systems under construction, and systems planned. The current total FGD-controlled capacity in the United States is 67,091 MW.

  10. Utility FGD survey: January--December 1989

    Energy Technology Data Exchange (ETDEWEB)

    Hance, S.L.; McKibben, R.S.; Jones, F.M.

    1992-03-01

    This is Volume 1 of the Utility flue gas desulfurization (FGD) Survey report, which is generated by a computerized data base management system, represents a survey of operational and planned domestic utility flue gas desulfurization (FGD) systems. It summarizes information contributed by the utility industry, system and equipment suppliers, system designers, research organizations, and regulatory agencies. The data cover system design, fuel characteristics, operating history, and actual system performance. Also included is a unit-by-unit discussion of problems and solutions associated with the boilers, scrubbers, and FGD systems. The development status (operational, under construction, or in the planning stages), system supplier, process, waste disposal practice, and regulatory class are tabulated alphabetically by utility company.

  11. Healthcare Cost and Utilization Project (HCUP)

    Science.gov (United States)

    The Healthcare Cost and Utilization Project is a family of health care databases and related software tools and products developed through a Federal-State-Industry partnership and sponsored by the Agency for Healthcare Research and Quality.

  12. Utilizing Data from Cancer Patient & Survivor Studies

    Science.gov (United States)

    Utilizing Data from Cancer Patient & Survivor Studies and Understanding the Current State of Knowledge and Developing Future Research Priorities, a 2011 workshop sponsored by the Epidemiology and Genomics Research Program.

  13. CROSS DRIFT ALCOVE/NICHE UTILITIES ANALYSIS

    Energy Technology Data Exchange (ETDEWEB)

    S. Goodin

    1999-07-08

    The purpose of this analysis is to provide the design basis and general arrangement requirements of the non-potable water, waste water, compressed air and ventilation (post excavation) utilities required in support of the Cross Drift alcoves and niches.

  14. Molecular characterization of autochthonous hydrocarbon utilizing ...

    African Journals Online (AJOL)

    Hydrocarbon utilizing bacteria in water, soil and sediment samples collected from ... of the genomic DNA extracted from each bacterial isolate was amplified with ... that16S rRNA-gene-based techniques be used when studying the bacterial ...

  15. Medicares Hospice Benefit - Analysis of Utilization and..

    Data.gov (United States)

    U.S. Department of Health & Human Services — Descriptive analyses reported in Medicares Hospice Benefit - Analysis of Utilization and Resource Use, published in Volume 4, Issue 3 of the Medicare and Medicaid...

  16. Racing to be an indispensable utility

    CERN Multimedia

    2003-01-01

    "Every major IT supplier is rushing to be involved in the global computing grid, eager to take advantage of the developments and experience they will gain. Why? Because the race is on to become an IT utility" (1 page).

  17. ARC Code TI: CFD Utility Software Library

    Data.gov (United States)

    National Aeronautics and Space Administration — The CFD Utility Software Library consists of nearly 30 libraries of Fortran 90 and 77 subroutines and almost 100 applications built on those libraries. Many of the...

  18. AFSC/ABL: Juvenile rockfish habitat utilization

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Juvenile rockfish were observed amongst coral, sponge, cobble, and gravel habitats. Rockfish utilized coral habitats more than any other, while gravel was the least...

  19. Industrial low temperature utilization of geothermal resources

    Energy Technology Data Exchange (ETDEWEB)

    Howard, J.H.

    1976-05-01

    This brief presentation on industrial utilization of low temperature geothermal resources first considers an overview of what has been achieved in using geothermal resources in this way and, second, considers potential, future industrial applications.

  20. Asset Management for Water and Wastewater Utilities

    Science.gov (United States)

    Renewing and replacing the nation's public water infrastructure is an ongoing task. Asset management can help a utility maximize the value of its capital as well as its operations and maintenance dollars.

  1. Medicare Provider Utilization and Payment Data

    Data.gov (United States)

    U.S. Department of Health & Human Services — CMS has released a series of publicly available data files that summarize the utilization and payments for procedures, services, and prescription drugs provided to...

  2. Metabolic Engineering for Substrate Co-utilization

    Science.gov (United States)

    Gawand, Pratish

    Production of biofuels and bio-based chemicals is being increasingly pursued by chemical industry to reduce its dependence on petroleum. Lignocellulosic biomass (LCB) is an abundant source of sugars that can be used for producing biofuels and bio-based chemicals using fermentation. Hydrolysis of LCB results in a mixture of sugars mainly composed of glucose and xylose. Fermentation of such a sugar mixture presents multiple technical challenges at industrial scale. Most industrial microorganisms utilize sugars in a sequential manner due to the regulatory phenomenon of carbon catabolite repression (CCR). Due to sequential utilization of sugars, the LCB-based fermentation processes suffer low productivities and complicated operation. Performance of fermentation processes can be improved by metabolic engineering of microorganisms to obtain superior characteristics such as high product yield. With increased computational power and availability of complete genomes of microorganisms, use of model-based metabolic engineering is now a common practice. The problem of sequential sugar utilization, however, is a regulatory problem, and metabolic models have never been used to solve such regulatory problems. The focus of this thesis is to use model-guided metabolic engineering to construct industrial strains capable of co-utilizing sugars. First, we develop a novel bilevel optimization algorithm SimUp, that uses metabolic models to identify reaction deletion strategies to force co-utilization of two sugars. We then use SimUp to identify reaction deletion strategies to force glucose-xylose co-utilization in Escherichia coli. To validate SimUp predictions, we construct three mutants with multiple gene knockouts and test them for glucose-xylose utilization characteristics. Two mutants, designated as LMSE2 and LMSE5, are shown to co-utilize glucose and xylose in agreement with SimUp predictions. To understand the molecular mechanism involved in glucose-xylose co-utilization of the

  3. Utility maximization in incomplete markets with default

    CERN Document Server

    Lim, Thomas

    2008-01-01

    We adress the maximization problem of expected utility from terminal wealth. The special feature of this paper is that we consider a financial market where the price process of risky assets can have a default time. Using dynamic programming, we characterize the value function with a backward stochastic differential equation and the optimal portfolio policies. We separately treat the cases of exponential, power and logarithmic utility.

  4. Evolution of non-expected utility preferences

    CERN Document Server

    Widekind, Sven von; Fandel, G

    2008-01-01

    The theory on the evolution of preferences deals with the endogenous formation of preference relations in strategic situations. It is related to the field of evolutionary game theory. In this book we analyze the role and the influence of general, possibly non-expected utility preferences in such an evolutionary setup. In particular, we demonstrate that preferences which diverge from von Neumann-Morgenstern expected utility may potentially prove to be successful under evolutionary pressures.

  5. Evaluation of energy roof direct utilization

    Energy Technology Data Exchange (ETDEWEB)

    Lazzarin, R.; Rossetto, L.; Viero, L.

    1984-04-01

    Energy roofs are roofing systems equipped with channels which allow both solar and atmospheric energy collection. They were conceived as cold source for heat pump systems. The behavious of an energy roof in DHW direct heating was studied; this might extend energy roof utilization all year long. The estimates were performed through more reliable recently proposed correlations for wind convection heat transfer coefficients. The advantage of annual energy roof utilization in DHW direct heating is predictable.

  6. Utility interconnection issues for wind power generation

    Science.gov (United States)

    Herrera, J. I.; Lawler, J. S.; Reddoch, T. W.; Sullivan, R. L.

    1986-01-01

    This document organizes the total range of utility related issues, reviews wind turbine control and dynamic characteristics, identifies the interaction of wind turbines to electric utility systems, and identifies areas for future research. The material is organized at three levels: the wind turbine, its controls and characteristics; connection strategies as dispersed or WPSs; and the composite issue of planning and operating the electric power system with wind generated electricity.

  7. Utilization of the terrestrial cyanobacterial sheet

    Science.gov (United States)

    Katoh, Hiroshi; Tomita-Yokotani, Kaori; Furukawa, Jun; Kimura, Shunta; Yamaguchi, Yuji; Takenaka, Hiroyuki; Kohno, Nobuyuki

    2016-07-01

    The terrestrial nitrogen-fixing cyanobacterium, Nostoc commune, is living ranging from polar to desert. N. commune makes visible colonies composed extracellular polymeric substances. N. commune has expected to utilize for agriculture, food and terraforming cause of its extracellular polysaccharide, desiccation tolerance and nitrogen fixation. To exhibit the potential abilities, the N. commune sheet is made to use convenient and evaluated by plant growth and radioactive accumulation. We will discuss utilization of terrestrial cyanobacteria under closed environment.

  8. A Sustainability Assessment Protocol for Geothermal Utilization

    OpenAIRE

    Shortall, Ruth, 1981-

    2010-01-01

    Sustainable development calls for the use of sustainable energy systems. However, the way in which a geothermal resource is utilized will ultimately determine whether or not it is sustainable. Sustainable utilization of geothermal energy means that it is produced and used in such a way that is compatible with the well-being of future generations and the environment (UNDP, 2000). A measurement and assessment framework is needed for a sustainable energy development strategy, as it can prov...

  9. Has branding failed the utility industry?

    Energy Technology Data Exchange (ETDEWEB)

    Brew, A. [Addison, New York, NY (United States)]|[Addison, San Francisco, CA (United States)]|[Addison, Chicago, IL (United States); Phelps, L. [Phelps Consulting Group (United States)

    1998-11-01

    Some flawed, and now discredited, experiments have thrown a shadow over the value of branding in the utility industry. But brands do have power in the energy industry, if they are well conceived and their execution is well supported. Branding has been enthusiastically embraced by those industries that are bearing the brunt of regulatory and technological changes. At the forefront of these are the telecommunications, airlines, financial services, and power utilities industries.

  10. Utilization of renewable energy in architectural design

    Institute of Scientific and Technical Information of China (English)

    TIAN Lei; QIN Youguo

    2007-01-01

    Renewable energy does not simply equal to using a photovoltaic (PV) board.In addition to heating,ventilation and air conditioning (HVAC) engineering considerations,the design approaches of architects are crucial to the utilization condition and methods of renewable energy.Through profound comprehension of the relationship between renewable energy utilization and design approaches,we can achieve a dual-standard of building environment performance and esthetics.

  11. Optical fibre cable selection for electricity utilities

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    The report provides an assessment of the range of optical fibre cable solutions available, by type e.g. OPGW, ADSS, rather than by design. it also examines the key issues which will influence an electricity utilities decisions and proposes a method of evaluating the options to identify the one which most closely matches the utility's critical needs, with measurements against time, cost and quality targets. (author)

  12. Analyzing Distributed Processing For Electric Utilities

    Science.gov (United States)

    Klein, Stanley A.; Kirkham, Harold; Beardmore, Julie A.

    1990-01-01

    Distributed Processing Trade-Off Model for Electric Utility Operation computer program based upon study performed at California Institute of Technology for NASA's Jet Propulsion Laboratory. Study presented technique addressing question of tradeoffs between expanding communications network or expanding capacity of distributed computers in energy-management systems (EMS) of electric utility. Gives EMS planners macroscopic tool for evaluation of architectures of distributed-processing systems and major technical and economic tradeoffs as well as interactions within systems.

  13. Local government and utility firms’ debts

    Directory of Open Access Journals (Sweden)

    Marko Primorac

    2011-12-01

    Full Text Available The global financial crisis has affected the Croatian local public sector. In such circumstances, local government units’ debts and borrowing should be approached with caution. The highly interwoven financial operations of local government units and their utilities indicate the need for analysis of consolidated financial statements of local governments and utility companies in order to gain an insight into the real financial “health” of local units. Accordingly, the main aim of this paper is to analyze the size and the structure of the consolidated (local government and utility companies local public debt in Croatia. Accordingly, the paper presents the financial position of local government units supplemented with information on the financial operations of utility companies, with particular emphasis on the size and structure of their liabilities and gross and net debt. Although the current Budget Law does not require formal preparation of consolidated financial statements by local governments and their utility firms, consolidation is stipulated by International Public Sector Accounting Standards (IPSAS. The application of IPSAS regulations would be helpful in determining overall direct and indirect exposure of local government units arising from the financial operations of their utilities.

  14. Report on promotion of utilization of radiation

    Energy Technology Data Exchange (ETDEWEB)

    1987-09-01

    This report presents results of studies made by the Atomic Energy Commission concerning research and development activities to be carried out in future to promote the utilization of radiation. First, the current state of radiation utilization is described, centering on practical applications, research and development activities (for practical and advanced applications), and international cooperation (with developing and advanced nations). The second part deals with activities required in future to promote practical utilization of radiation, research and development of advanced techniques, and cooperation to be offered to developing countries. Third, specific measures to be carried out for effective radiation utilization are described. For ..gamma..-rays and electron beams, which are widely in use at present, there are some economic and social problems remaining to be solved. For advanced utilization of radiation beams, further efforts should be focused on basic research on ..pi..-meson and ..mu..-particle beams and their application to canser treatment and nuclear fusion; research on monochromatic neutron beams; application of RI beams to the development of new materials and new analysis techniques, application of epithermal neutron beams to elementary radiography and CT; etc. The utilization, application and development of tracers are also described. (Nogami, K.).

  15. Utility applications program. Annual report for 1981

    Energy Technology Data Exchange (ETDEWEB)

    Doherty, T.J.; Loscutoff, W.V.

    1982-06-01

    The purpose of the Utility Applications Program is to provide information and assistance to interested utilities on central station energy storage systems. Compressed air and underground pumped hydroelectric energy storage are the primary technical focus. Smaller utilities are the primary targets of this program, as they may not have resources to track and utilize new energy conservation developments. The program, initiated during this year-long period, consists of a series of tasks integrating and supporting energy storage implementation. Program management and technical coordination activities monitor the wide range of research ongoing both under government support and in industry and provide a locus for dissemination of results. Recently completed DOE demonstration studies provide the central data base and the DOE CAES and UPH Technology Program activities provide another major resource. In addition a UPH preliminary feasibility study in coorination with Central Vermont Public Servie (CVPS), a Northeast utility, was carried out. The major program activity this period was a comprehensive technology assessment and environmental siting study, performed in coordination with the Soyland Power Cooperative in Decatur, Illinois. The reports from this work established solid siting precedents for CAES application in the US and jointly assisted the utility in assembling the required baseline information for ongoing technical and financial development of the first US compressed air energy storage facility.

  16. Trends in Utility Green Pricing Programs (2005)

    Energy Technology Data Exchange (ETDEWEB)

    Bird, Lori [National Renewable Energy Lab. (NREL), Golden, CO (United States); Brown, Elizabeth [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2006-10-01

    In the early 1990s, only a handful of utilities offered their customers a choice of purchasing electricity generated from renewable energy sources. Today, more than 600 utilities—or about 20% of all utilities nationally—provide their customers a “green power” option. Because some utilities offer programs in conjunction with cooperative associations or other publicly owned power entities, the number of distinct programs totals more than 130. Through these programs, more than 50 million customers have the ability to purchase renewable energy to meet some portion or all of their electricity needs—or make contributions to support the development of renewable energy resources. Typically, customers pay a premium above standard electricity rates for this service. This report presents year-end 2005 data on utility green pricing programs, and examines trends in consumer response and program implementation over time. The data in this report, which were obtained via a questionnaire distributed to utility green pricing program managers, can be used by utilities to benchmark the success of their green power programs.

  17. 眼球后静脉注射建立小鼠非清髓同种异基因骨髓细胞移植模型%Establishment of non-myeloablative allogeneic bone marrow transplantation model in mice via retro-orbital injection

    Institute of Scientific and Technical Information of China (English)

    于力方; 刘乔飞; 贾艳娥

    2012-01-01

    目的:验证利用眼球后静脉注射( retro-orbital injection,ROI)建立小鼠非清髓同种异基因骨髓细胞移植(Non-allogeneic myeloablative bone marrow cell transplantation,N-Allo-BMT)模型的可行性和安全性,寻找替代尾静脉注射(tail vein injection,TVI)进行小鼠细胞移植的理想途径.方法:对比10名志愿者从练习到掌握ROI与TVI所需时间;经ROI建立N-Allo-BMT模型,利用外周血瑞氏染色及流式细胞计数,连续观测外周血像及嵌合情况,观察移植物抗宿主疾病(GVHD)发生情况.结果:所有志愿者均在1~3h内能熟练完成ROI,且无注射相关并发症发生;在移植10d后,受体小鼠完全恢复造血,外周血呈供体完全嵌合;在移植75d内,83.3%的受体死于严重GVHD.讨论:ROI是一种简便、安全、可靠的小鼠骨髓细胞移植方法,可代替操作难度较大的TVI,值得推广.

  18. Iranian nurses' constraint for research utilization

    Directory of Open Access Journals (Sweden)

    Mehrdad Neda

    2009-09-01

    Full Text Available Abstract Background This paper identifies the views of Iranian clinical nurses regarding the utilization of nursing research in practice. There is a need to understand what restricts Iranian clinical nurses to use research findings. The aim of this study was to identify practicing nurses' view of aspects which they perceived constrain them from research utilization that summarizes and uses research findings to address a nursing practice problem. Methods Data were collected during 6 months by means of face-to face interviews follow by one focus group. Analysis was undertaken using a qualitative content analysis. Results Findings disclosed some key themes perceived by nurses to restrict them to use research findings: level of support require to be research active, to be research minded, the extent of nurses knowledge and skills about research and research utilization, level of educational preparation relating to using research, administration and executive challenges in clinical setting, and theory-practice gap. Conclusion This study identifies constraints that require to be overcome for clinical nurses to actively get involved in research utilization. In this study nurses were generally interested to use research findings. However they felt restricted because of lack of time, lack of peer and manager support and limited knowledge and skills of the research process. This study also confirms that research utilization and the change to research nursing practice are complex issues which require both organizational and educational efforts.

  19. Information security becoming a priority for utilities

    Energy Technology Data Exchange (ETDEWEB)

    Nicolaides, S. [Numerex, Atlanta, GA (United States)

    2009-10-15

    As part of North America's national critical infrastructure, utilities are finding themselves at the forefront of a security issue. In October 2007, a leading security service provider reported a 90 per cent increase in the number of hackers attempting to attack its utility clients in just one year. Utilities are vulnerable to cyber attacks that could disrupt power production and the transmission system. This article discussed the need for intelligent technologies in securely enabling resource management and operational efficiency of the utilities market. It discussed the unique security challenges that utilities face at a time of greater regulatory activity, heightened environmental concerns, tighter data security requirements and an increasing need for remote monitoring and control. A new tool has emerged for cyber security in the form of an international standard that may offer a strong guideline to work toward 11 security domains. These include security policy; organization of information security; asset management; human resources security; physical and environmental security; communications and operations management; access control; information systems acquisition; development and maintenance; information security incident management; business continuity management; and compliance. 2 figs.

  20. Universally Utility-Maximizing Privacy Mechanisms

    CERN Document Server

    Ghosh, Arpita; Sundararajan, Mukund

    2008-01-01

    A mechanism for releasing information about a statistical database with sensitive data must resolve a trade-off between utility and privacy. Privacy can be rigorously quantified using the framework of {\\em differential privacy}, which requires that a mechanism's output distribution is nearly the same (in a strong sense) whether or not a given database row is included or excluded. In this paper, we pursue much strong and general utility guarantees. We seek a mechanism that guarantees near-optimal utility to every potential user, independent of its side information. Formally, we model the side information of a potential user as a prior distribution over query results. An interaction between a user and a mechanism induces a posterior distribution, and we define the utility of the mechanism for this user as the accuracy of this posterior, as quantified via a user-specific loss function. A differentially private mechanism $M$ is (near-)optimal for a given user $u$ if $u$ derives (almost) as much utility from $M$ a...

  1. Equity in health care utilization in Chile

    Science.gov (United States)

    2013-01-01

    One of the most extensive Chilean health care reforms occurred in July 2005, when the Regime of Explicit Health Guarantees (AUGE) became effective. This reform guarantees coverage for a specific set of health conditions. Thus, the purpose of this study is to provide timely evidence for policy makers to understand the current distribution and equity of health care utilization in Chile. The authors analyzed secondary data from the National Socioeconomic Survey (CASEN) for the years 1992–2009 and the 2006 Satisfaction and Out-of-Pocket Payment Survey to assess equity in health care utilization using two different approaches. First, we used a two-part model to estimate factors associated with the utilization of health care. Second, we decomposed income-related inequalities in medical care use into contributions of need and non-need factors and estimated a horizontal inequity index. Findings of this empirical study include evidence of inequities in the Chilean health care system that are beneficial to the better-off. We also identified some key factors, including education and health care payment, which affect the utilization of health care services. Results of this study could help researchers and policy makers identify targets for improving equity in health care utilization and strengthening availability of health care services accordingly. PMID:23937894

  2. A bayesian approach to laboratory utilization management

    Directory of Open Access Journals (Sweden)

    Ronald G Hauser

    2015-01-01

    Full Text Available Background: Laboratory utilization management describes a process designed to increase healthcare value by altering requests for laboratory services. A typical approach to monitor and prioritize interventions involves audits of laboratory orders against specific criteria, defined as rule-based laboratory utilization management. This approach has inherent limitations. First, rules are inflexible. They adapt poorly to the ambiguity of medical decision-making. Second, rules judge the context of a decision instead of the patient outcome allowing an order to simultaneously save a life and break a rule. Third, rules can threaten physician autonomy when used in a performance evaluation. Methods: We developed an alternative to rule-based laboratory utilization. The core idea comes from a formula used in epidemiology to estimate disease prevalence. The equation relates four terms: the prevalence of disease, the proportion of positive tests, test sensitivity and test specificity. When applied to a laboratory utilization audit, the formula estimates the prevalence of disease (pretest probability [PTP] in the patients tested. The comparison of PTPs among different providers, provider groups, or patient cohorts produces an objective evaluation of laboratory requests. We demonstrate the model in a review of tests for enterovirus (EV meningitis. Results: The model identified subpopulations within the cohort with a low prevalence of disease. These low prevalence groups shared demographic and seasonal factors known to protect against EV meningitis. This suggests too many orders occurred from patients at low risk for EV. Conclusion: We introduce a new method for laboratory utilization management programs to audit laboratory services.

  3. Development of beam utilization/application technology

    Energy Technology Data Exchange (ETDEWEB)

    Choi, B. H.; Kim, Y.K.; Song, T.Y. [and others

    1999-05-01

    High power proton accelerator is considered as one of national fundamental research facilities and a key to advanced nuclear technology development, having been widely used in an un detachable relationship with nuclear research in advanced countries. The high power proton accelerator will be installed in several phases as an up front facility of the nuclear waste transmutation system. It is expected that a common understanding and a general agreement over proper utilization of the accelerator should be deduced and that a user program for beam utilization and application should be firmly established in time for the completion of each phase of the accelerator. This high power proton accelerator will consist of several component accelerators and, from up front, accelerators such as injector, RFQ, CCDTL, etc. will be installed in sequence and deliver respectively at each stage beams of 3MeV, 20MeV, 100Mev, etc. to be variously utilized forindustries, defence industry, medical treatment, environmental protection and basic science research. In order for the accelerator to be fully utilized as a national fundamental research facility beyond nuclear field, it is necessary to formulate a proceeding plan of the user program for the accelerator and to cultivate industrial utilization/application studies of proton beams accelerated by injector or RFQ of the accelerator. (author). 38 refs., 84 tabs., 39 figs.

  4. Industrial co-generation: Its utilization by the electric utility business

    Energy Technology Data Exchange (ETDEWEB)

    Basu, S. [ComEd, Chicago, IL (United States); Behera, A.K.; Beck, C.E. [Illinois Inst. of Tech., Chicago, IL (United States). Dept. of Electrical and Computer Engineering

    1996-11-01

    Industrial Co-Generation has not only an adverse impact on electric utility earnings, but also a positive impact, in that it permits a reduction in capital expenditures related to construction of new generation plants as a means of meeting future load growth. A utility can benefit economically by persuading companies considering industrial co-generation to use their generators for peak load shaving only. This would reduce their maximum demand cost, and also allows the utility to normalize its maximum system demand.

  5. Time management problems and discounted utility.

    Science.gov (United States)

    König, Cornelius J; Kleinmann, Martin

    2007-05-01

    The lens of behavioral decision theory offers a new perspective for research on time management. The basic idea of this approach is that people discount future consequences of their time management decisions, meaning that they work on tasks with smaller but sooner outcomes rather than on tasks with larger but later outcomes. The authors performed 2 experimental studies to test whether people are sensitive to differences in the discounted utility of time management decisions. In Experiment 1, they used vignettes of typical time management situations; Experiment 2 was a laboratory simulation (an in-basket task that was part of a training assessment). Participants in both studies were German students. As expected, manipulating the discounted utility of options resulted in different time management decisions. In Experiment 1, reactions to time management situations were judged as less likely if the reactions had lower discounted utilities. In Experiment 2, people spent less time on an interruption.

  6. Construction utilization of foamed waste glass

    Institute of Scientific and Technical Information of China (English)

    Jiang LU; Katsutada ONITSUKA

    2004-01-01

    Foamed waste glass(FWG) material is newly developed for the purpose to utilize the waste glassware andother waste glass. FWG has a multi-porous structure that consists of continuous or discontinuous voids. Hencelightweight but considerable stiffness can be achieved. In the present study, the manufacture and engineeringproperties of FWG are introduced first. Then, the utilizations of FWG are investigated in laboratory tests and fieldtests. Some case studies on design and construction work are also reported here. Through these studies we knowthat the discontinuous void material can be utilized as a lightweight fill material, ground improvement material andlightweight aggregate for concrete. On the other hand, the continuous void material can be used as water holdingmaterial for the greening of ground slope and rooftop, and as clarification material for water.

  7. Marketing to utility customers with multimedia

    Energy Technology Data Exchange (ETDEWEB)

    Bernstein, S.; Tidball, R. [Energy International Inc., Bellevue, WA (United States)

    1997-09-01

    The rapid growth in both the power and availability of personal computers has created an opportunity for the utility industry to enhance the effectiveness of communication, training, and marketing tools through the use of multimedia programs. Multimedia communication and marketing packages can be created to promote specific technologies or to address the needs of specific business segments. In either case, multimedia programs can be structured to include a variety of technical, economic, and market data relevant to the subject matter. Multimedia programs allow this information to be presented on demand in a graphics-rich environment using a mix of text, graphics, animation, sound, and interactive calculation routines. Utility marketing personnel can use these multimedia packages to quickly and early present the information of most interest to customers. Possible uses for multimedia in the utility industry are described and examples of programs that have been developed are presented. (author)

  8. Independence properties Vis-A-Vis several utility representations

    NARCIS (Netherlands)

    Marley, AAJ; Luce, RD

    2005-01-01

    A detailed theoretical analysis is presented of what five utility representations - subjective expected utility (SEU), rank-dependent (cumulative or Choquet) utility (RDU), gains decomposition utility (GDU), rank weighted utility (RWU), and a configural-weight model (TAX) that we show to be equivale

  9. Distributed generation the next frontier for utilities

    Energy Technology Data Exchange (ETDEWEB)

    Whitehead, K. [Whitby Hydro Electric Commission, ON (Canada)

    2001-09-01

    Fluctuating energy costs, fewer resources and ever-increasing end-user demand are some of the challenges facing electric utilities today. At the same time, advances in technology allow for improved service and reduced capital costs by means of innovative and cost-effective solutions. It is expected that deregulation of energy markets will result in energy being considered as a mere commodity to be freely sold or bought. Also, based on the assets of the utility, the regulators will determine what the utility is allowed to sell power for, which is called Performance-Based Rates. In turn, the rates determine the staffing requirements of the utility and the degree to which it can be maintained. Less reliable power delivery to the user could be the consequence as the utility is compelled to cut costs. Demand exceeding the supply for the next few years only makes the problem worse. Meeting the additional demand means adding feeders and transformer stations at the cost of 12 to 20 million dollars for a new transformer station. A possible solution is on-site power generation through distributed generation. For example, industrial users equipped with an existing generator, would parallel the grid to handle peak volumes through on-site generation. Some of the new technologies being considered are micro-turbines which have the advantage of built-in communications capabilities, and fuel cells which should become available in the next five years and offer environmentally friendly options. At the moment, for the utilities to benefit from on-site generation in the short term, they must look to small gas turbines and reciprocating engines. Distributed generation offers improved system reliability and quality, as well as the ability to defer capital costs required for a new transformer station. The major hurdle to be overcome is communication with the host site for monitoring and control. Connectivity issues are now being addressed with open systems (protection, monitoring and

  10. Supplier Selection Using Weighted Utility Additive Method

    Science.gov (United States)

    Karande, Prasad; Chakraborty, Shankar

    2015-10-01

    Supplier selection is a multi-criteria decision-making (MCDM) problem which mainly involves evaluating a number of available suppliers according to a set of common criteria for choosing the best one to meet the organizational needs. For any manufacturing or service organization, selecting the right upstream suppliers is a key success factor that will significantly reduce purchasing cost, increase downstream customer satisfaction and improve competitive ability. The past researchers have attempted to solve the supplier selection problem employing different MCDM techniques which involve active participation of the decision makers in the decision-making process. This paper deals with the application of weighted utility additive (WUTA) method for solving supplier selection problems. The WUTA method, an extension of utility additive approach, is based on ordinal regression and consists of building a piece-wise linear additive decision model from a preference structure using linear programming (LP). It adopts preference disaggregation principle and addresses the decision-making activities through operational models which need implicit preferences in the form of a preorder of reference alternatives or a subset of these alternatives present in the process. The preferential preorder provided by the decision maker is used as a restriction of a LP problem, which has its own objective function, minimization of the sum of the errors associated with the ranking of each alternative. Based on a given reference ranking of alternatives, one or more additive utility functions are derived. Using these utility functions, the weighted utilities for individual criterion values are combined into an overall weighted utility for a given alternative. It is observed that WUTA method, having a sound mathematical background, can provide accurate ranking to the candidate suppliers and choose the best one to fulfill the organizational requirements. Two real time examples are illustrated to prove

  11. Handbook of evaluation of utility DSM programs

    Energy Technology Data Exchange (ETDEWEB)

    Hirst, E.; Reed, J. [eds.; Bronfman, B.; Fitzpatrick, G.; Hicks, E.; Hirst, E.; Hoffman, M.; Keating, K.; Michaels, H.; Nadel, S.; Peters, J.; Reed, J.; Saxonis, W.; Schoen, A.; Violette, D.

    1991-12-01

    Program evaluation has become a central issue in the world of utility integrated resource planning. The DSM programs that utilities were operating to meet federal requirements or to improve customer relations are now becoming big business. DSM is being considered an important resource in a utility`s portfolio of options. In the last five years, the amount of money that utilities have invested in DSM has grown exponentially in most regulatory jurisdictions. Market analysts are now talking about DSM being a $30 billion industry by the end of the decade. If the large volume of DSM-program investments was not enough to highlight the importance of evaluation, then the introduction of regulatory incentives has really focused the spotlight. This handbook was developed through a process that involved many of those people who represent the diverse constituencies of DSM-program evaluation. We have come to recognize the many technical disciplines that must be employed to evaluate DSM programs. An analysis might start out based on the principles of utility load research to find out what happened, but a combination of engineering and statistical methods must be used to ``triangulate`` an estimate of what would have happened without the program. The difference, of course, is that elusive but prized result of evaluation: what happened as the direct result of the DSM program. Technical performance of DSM measures is not the sole determinant of the answer, either. We also recognize the importance of such behavioral attributes of DSM as persistence and free ridership. Finally, DSM evaluation is meaningless without attention to planning an approach, communicating results to relevant decision-makers, and focusing as much on the process as the impacts of the program. These topics are all covered in this handbook.

  12. Hydrogen utilization potential in subsurface sediments

    DEFF Research Database (Denmark)

    Adhikari, Rishi Ram; Glombitza, Clemens; Nickel, Julia

    2016-01-01

    Pacific, and Gulf of Mexico) with different predominant electron-acceptors. Hydrogenases constitute a diverse family of enzymes expressed by microorganisms that utilize molecular hydrogen as a metabolic substrate, product, or intermediate. The assay reveals the potential for utilizing molecular hydrogen...... and allows qualitative detection of microbial activity irrespective of the predominant electron-accepting process. Because the method only requires samples frozen immediately after recovery, the assay can be used for identifying microbial activity in subsurface ecosystems without the need to preserve live...

  13. An Efficient Framework to Utilize Grover Search

    Institute of Scientific and Technical Information of China (English)

    Shigeru Yamashita; Masaki Nakanishi

    2011-01-01

    This paper proposes an efficient framework to utilize quantum search practically.To the best of our knowledge,this is the first paper to show a concrete usage of quantum search in general programming.In our framework, we can utilize a quantum computer as a coprocessor to speed-up some parts of a program that runs on a classical computer.To do so,we propose several new ideas and techniques,such as a practical method to design a large quantum circuits for search problems and an efficient quantum comparator.

  14. Studies on nitrogen utilization in ruminants

    OpenAIRE

    Batista, Erick Darlisson

    2015-01-01

    In cattle, efficiency of nitrogen (N) utilization (g N in product/g N intake) is lower compared to others species (e.g., pig, chicken). For that reason, there is an extensive loss of N in manure, leading to environmental pollution. However, understanding the key mechanisms involved in control of N metabolism, such as efficiency of N capture in the rumen from recycled N and metabolism of amino acids (AA) in the body can improve efficiency of N utilization. To understand these factors, this dis...

  15. Floodwater utilization of the Three Gorges Project

    Institute of Scientific and Technical Information of China (English)

    DONG Qian-jin; CAO Guang-jing; DAI Hui-cao; ZHAO Yun-fa

    2009-01-01

    Floods are both risks and resources. Floodwater utilization is an important part of flood management. Considering the rising shortage of water resources, serious water pollution, and undersupply of electric power, it's imperative to strengthen flood management. In light of the hydrological characteristics of the Three Gorges Project (TGP) on the Yangtze River in P. R. China, we investigated the necessity and feasibility of TGP floodwater utilization, proprosed dynamic control of limited water level during flood season of the reservoir and basin-wide integrated floodwater management as strategies, and identified problems that might occur in practice.

  16. Addiction and the Utilization of Medical Care

    Directory of Open Access Journals (Sweden)

    Yen-Ju Lin

    2012-01-01

    Full Text Available We investigate the effect of different scales of addictive factors on the utilization of medical services in this paper using a two-part model. Data are from the 2005 National Health Interview Survey and the claims data in the National Health Insurance Research Database in Taiwan. The results show that personal addictive behavior is significantly associated with both outpatient and inpatient utilization. Moreover, our result implies that those who smoked at least 20 cigarettes per day might not visit a doctor until the illness was severe. It suggests that the government can accomplish these goals by promotion and education in order to increase public awareness of personal health.

  17. Assessment of Research Needs for Coal Utilization

    Energy Technology Data Exchange (ETDEWEB)

    Penner, S.S.

    1983-08-01

    The Coal Combustion and Applications Working Group (CCAWG), at the request of J.W. Mares (Assistant Secretary for Fossil Energy) and A.W. Trivelpiece (Director, Office of Energy Research), has reviewed and evaluated the U.S. programs on coal combustion and utilization. The important topical areas of coal gasification and coal liquefaction have been deliberately excluded because R and D needs for these technologies were reviewed previously by the DOE Fossil Energy Research Working Group. The CCAWG studies were performed in order to provide an independent assessment of research areas that affect prospects for augmented coal utilization. In this report, we summarize the findings and research recommendations of CCAWG.

  18. Establishing benchmarks and metrics for utilization management.

    Science.gov (United States)

    Melanson, Stacy E F

    2014-01-01

    The changing environment of healthcare reimbursement is rapidly leading to a renewed appreciation of the importance of utilization management in the clinical laboratory. The process of benchmarking of laboratory operations is well established for comparing organizational performance to other hospitals (peers) and for trending data over time through internal benchmarks. However, there are relatively few resources available to assist organizations in benchmarking for laboratory utilization management. This article will review the topic of laboratory benchmarking with a focus on the available literature and services to assist in managing physician requests for laboratory testing. © 2013.

  19. Utility Constrained Energy Minimization In Aloha Networks

    CERN Document Server

    Khodaian, Amir Mahdi; Talebi, Mohammad S

    2010-01-01

    In this paper we consider the issue of energy efficiency in random access networks and show that optimizing transmission probabilities of nodes can enhance network performance in terms of energy consumption and fairness. First, we propose a heuristic power control method that improves throughput, and then we model the Utility Constrained Energy Minimization (UCEM) problem in which the utility constraint takes into account single and multi node performance. UCEM is modeled as a convex optimization problem and Sequential Quadratic Programming (SQP) is used to find optimal transmission probabilities. Numerical results show that our method can achieve fairness, reduce energy consumption and enhance lifetime of such networks.

  20. Fusion Utility in the Knudsen Layer

    Energy Technology Data Exchange (ETDEWEB)

    Davidovits, Seth [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Fisch, Nathaniel J. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States)

    2014-08-01

    In inertial confi nement fusion, the loss of fast ions from the edge of the fusing hot-spot region reduces the reactivity below its Maxwellian value. The loss of fast ions may be pronounced because of the long mean free paths of fast ions, compared to those of thermal ions. We introduce a fusion utility function to demonstrate essential features of this Knudsen layer e ffect, in both magnetized and unmagnetized cases. The fusion utility concept is also used to evaluate restoring the reactivity in the Knudsen layer by manipulating fast ions in phase space using waves.

  1. Robust utility maximization in a discontinuous filtration

    CERN Document Server

    Jeanblanc, Monique; Ngoupeyou, Armand

    2012-01-01

    We study a problem of utility maximization under model uncertainty with information including jumps. We prove first that the value process of the robust stochastic control problem is described by the solution of a quadratic-exponential backward stochastic differential equation with jumps. Then, we establish a dynamic maximum principle for the optimal control of the maximization problem. The characterization of the optimal model and the optimal control (consumption-investment) is given via a forward-backward system which generalizes the result of Duffie and Skiadas (1994) and El Karoui, Peng and Quenez (2001) in the case of maximization of recursive utilities including model with jumps.

  2. Liquefaction chemistry and kinetics: Hydrogen utilization studies

    Energy Technology Data Exchange (ETDEWEB)

    Rothenberger, K.S.; Warzinski, R.P.; Cugini, A.V. [Pittsburgh Energy Technology Center, PA (United States)] [and others

    1995-12-31

    The objectives of this project are to investigate the chemistry and kinetics that occur in the initial stages of coal liquefaction and to determine the effects of hydrogen pressure, catalyst activity, and solvent type on the quantity and quality of the products produced. The project comprises three tasks: (1) preconversion chemistry and kinetics, (2) hydrogen utilization studies, and (3) assessment of kinetic models for liquefaction. The hydrogen utilization studies work will be the main topic of this report. However, the other tasks are briefly described.

  3. Utility Independence of Multiattribute Utility Theory is Equivalent to Standard Sequence Invariance of Conjoint Measurement

    NARCIS (Netherlands)

    H. Bleichrodt (Han); J.N. Doctor (Jason); M. Filko (Martin); P.P. Wakker (Peter)

    2011-01-01

    textabstractUtility independence is a central condition in multiattribute utility theory, where attributes of outcomes are aggregated in the context of risk. The aggregation of attributes in the absence of risk is studied in conjoint measurement. In conjoint measurement, standard sequences have been

  4. Under stochastic dominance choquet-expected utility and anticipated utility are identical

    NARCIS (Netherlands)

    P.P. Wakker

    1990-01-01

    The aim of this paper is to convince the reader that Choquet-expected utility, as initiated by Schmeidler (1982) for decision making under uncertainty, when formulated for decision making under risk naturally leads to Yaari (1987)'s anticipated utility. Thus the two generalizations of expected utili

  5. Under stochastic dominance Choquet-expected utility and anticipated utility are identical

    NARCIS (Netherlands)

    P.P. Wakker (Peter)

    1990-01-01

    textabstractThe aim of this paper is to convince the reader that Choquet-expected utility, as initiated by Schmeidler (1982, 1989) for decision making under uncertainty, when formulated for decision making under risk naturally leads to anticipated utility, as initiated by Quiggin/Yaari. Thus the two

  6. 48 CFR 970.4102 - Acquiring utility services.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Acquiring utility services... SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Acquisition of Utility Services 970.4102 Acquiring utility services....

  7. Utilities at Cedar Breaks National Monument, Utah (utilpnt)

    Data.gov (United States)

    National Park Service, Department of the Interior — This feature class represents various types of utilities, including water- and power-related utilities, at Cedar Breaks National Monument, Utah. The utilities were...

  8. Allogeneic Immunotherapy for Relapsed Multiple Myeloma:Role of Matched Unrelated Donors

    Institute of Scientific and Technical Information of China (English)

    M.Goerner; S.Hoepfner; 等

    2002-01-01

    Existence of a graft-versus-myeloma effect has been well documented by responses to donor lymphocyte infusions and long-term survival after allogeneic bone marrow transplantation.The development of non-myeloablative conditioning regimens allows utilization of allogeneic effects in patients usually not suitable for myeloablative allogeneic transplantation,such as older and heavily pretreated pa-tients.In a small series of 11 patients with multiple myeloma relapsing after autologous transplantation,we show that conditioning with low-dose total body irradiation in combination with fludarabine allows stable engraftment after matched unrelated donor transplantation and is tolerated with acceptable transplant-related morbidity and mortality.With a short median follow-up of 225 days,disease control was achieved only for patients responding to conventional treatment prior to allografting .Future studies with longer follow-up have to define the role of non-myeloablative allogeneic transplantation from unrelated donors as consolidation for patients responding to salvage therapy.

  9. ATTITUDE, KNOWLEDGE AND UTILIZATION OF FAMILY ...

    African Journals Online (AJOL)

    AGROSEARCH UIL

    At the World Summit of Food and Agricultural Organization. (FAO, 1996) ... particularly family planning directly impacts on the rural women in terms of their efforts on the farm, their ... adopted and utilized, factors militating against the use of family planning methods among rural women and ... Selected personal character tics.

  10. Energetic utilization of dietary fiber in pigs

    NARCIS (Netherlands)

    Rijnen, M.M.J.A.

    2003-01-01

    The energetic utilization of fermentable dietary fiber (fDF) of different fiber sources and its relation to physical activity and housing conditions was studied in three experiments. In all experiments the daily intake of digestible nutrients, nitrogen and energy balances, heat production, and activ

  11. A UTILITY THEORY OF OLD AGE.

    Science.gov (United States)

    HAMLIN, ROY M.

    HERZBERG'S JOB SATISFACTION MODEL SERVES AS THE BASIS FOR AN ANALYSIS OF OLD AGE. THE PATTERN VARIES AMONG INDIVIDUALS, BUT THE CAPACITY FOR ORGANIZED BEHAVIOR RATHER THAN RANDOM STRESS REDUCTION SUPPLIES EACH INDIVIDUAL WITH A TASK. THE HYPOTHESIS IS THAT IF THE OLDER INDIVIDUAL REALIZES UTILITY IN HIS YEARS BEYOND 70, HE WILL RETAIN COMPETENCE…

  12. Obsolescence, Weeding, and the Utilization of Space.

    Science.gov (United States)

    Lancaster, F. W.

    1988-01-01

    Suggests an objective approach to weeding library materials and discusses ways of measuring obsolescence and of controlling variables to provide a true picture of aging. Weeding is shown to improve space utilization and the quality of a collection. (5 references) (MES)

  13. Nitrogen-fixing methane-utilizing bacteria

    NARCIS (Netherlands)

    Bont, de J.A.M.

    1976-01-01

    Methane occurs abundantly in nature. In the presence of oxygen this gas may be metabolized by bacteria that are able to use it as carbon and energy source. Several types of bacteria involved in the oxidation of methane have been described in literature. Methane-utilizing bacteria have in common that

  14. 24 CFR 1710.211 - Utilities.

    Science.gov (United States)

    2010-04-01

    ... water. If the system is operated by a governmental division or by an entity whose operations are... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Utilities. 1710.211 Section 1710.211 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued...

  15. Subjective Expected Utility Theory with "Small Worlds"

    DEFF Research Database (Denmark)

    Gyntelberg, Jacob; Hansen, Frank

    which is a more general construction than a state space. We retain preference axioms similar in spirit to the Savage axioms and obtain, without abandoning linearity of expectations, a subjective expected utility theory which allows for an intuitive distinction between risk and uncertainty. We also...

  16. Trees and Shrubs for Overhead Utility Easements

    OpenAIRE

    Appleton, Bonnie Lee, 1948-2012; French, Sue (Sue C.); Johnson-Asnicar, Brenda; Relf, Diane; Day, Susan D.; Nunnally, Richard, 1947-; Vest, John

    2009-01-01

    Trees are one of the major causes of power outages in areas of overhead utility lines due to direct tree contact with lines, or to trees or tree limbs falling on the lines. This publication covers conflict resolution options and tree selection and planting when dealing with landscaping around power lines.

  17. A Simple Axiomatization of Nonadditive Expected Utility

    NARCIS (Netherlands)

    R.K. Sarin (Rakesh); P.P. Wakker (Peter)

    1992-01-01

    textabstractThis paper provides an extension of Savage's subjective expected utility theory for decisions under uncertainty. It includes in the set of events both unambiguous events for which probabilities are additive and ambiguous events for which probabilities are permitted to be nonadditive. The

  18. Utilizing of marketing research for marketing communication

    OpenAIRE

    Bielová, Zuzana

    2008-01-01

    The subject of bachelor's thesis "Utilizing of marketing research for marketing communication" is analyze problematic of marketing communications in sector of educational services. The aims are potential clients of education. I will try to make out import of marketing research for marketing communication of the company.

  19. Chiropractic and CAM Utilization: A Descriptive Review

    Directory of Open Access Journals (Sweden)

    Meeker William C

    2007-01-01

    Full Text Available Abstract Objective To conduct a descriptive review of the scientific literature examining use rates of modalities and procedures used by CAM clinicians to manage chronic LBP and other conditions Data Sources A literature of PubMed and MANTIS was performed using the key terms Chiropractic; Low Back Pain; Utilization Rate; Use Rate; Complementary and Alternative Medicine; and Health Services in various combinations. Data Selection A total of 137 papers were selected, based upon including information about chiropractic utilization, CAM utilization and low back pain and other conditions. Data Synthesis Information was extracted from each paper addressing use of chiropractic and CAM, and is summarized in tabular form. Results Thematic analysis of the paper topics indicated that there were 5 functional areas covered by the literature: back pain papers, general chiropractic papers, insurance-related papers, general CAM-related papers; and worker's compensation papers. Conclusion Studies looking at chiropractic utilization demonstrate that the rates vary, but generally fall into a range from around 6% to 12% of the population, most of whom seek chiropractic care for low back pain and not for organic disease or visceral dysfunction. CAM is itself used by people suffering from a variety of conditions, though it is often used not as a primary intervention, but rather as an additional form of care. CAM and chiropractic often offer lower costs for comparable results compared to conventional medicine.

  20. Maximizing Resource Utilization in Video Streaming Systems

    Science.gov (United States)

    Alsmirat, Mohammad Abdullah

    2013-01-01

    Video streaming has recently grown dramatically in popularity over the Internet, Cable TV, and wire-less networks. Because of the resource demanding nature of video streaming applications, maximizing resource utilization in any video streaming system is a key factor to increase the scalability and decrease the cost of the system. Resources to…

  1. SLURM: Simple Linux Utility for Resource Management

    Energy Technology Data Exchange (ETDEWEB)

    Jette, M; Grondona, M

    2002-12-19

    Simple Linux Utility for Resource Management (SLURM) is an open source, fault-tolerant, and highly scalable cluster management and job scheduling system for Linux clusters of thousands of nodes. Components include machine status, partition management, job management, scheduling and stream copy modules. This paper presents an overview of the SLURM architecture and functionality.

  2. Efficient marker data utilization in genomic prediction

    DEFF Research Database (Denmark)

    Edriss, Vahid

    Genomic prediction is a novel method to recognize the best animals for breeding. The aim of this PhD is to improve the accuracy of genomic prediction in dairy cattle by effeiently utilizing marker data. The thesis focuses on three aspects for improving the genomc prediction, which are: criteria...

  3. 78 FR 76973 - Financial Market Utilities

    Science.gov (United States)

    2013-12-20

    ... through the account provide certain financial services to, financial market utilities (``FMUs'') that are... accounts for and provide financial services to designated FMUs, as well as to set out provisions regarding... the establishment and maintenance of an account at, and provision of financial services from, a...

  4. The supply and utilization of dental services

    NARCIS (Netherlands)

    Groenewegen, P.P.; Postma, J.H.M.

    1984-01-01

    In this article the question is addressed whether regional differences in the supply of dental manpower influences the utilization of dental services. The percentage of the population that visits the dentist, is indeed higher in regions with a higher density of dentists. The number of people that vi

  5. Deriving minimal models for resource utilization

    NARCIS (Netherlands)

    te Brinke, Steven; Bockisch, Christoph; Bergmans, Lodewijk; Malakuti Khah Olun Abadi, Somayeh; Aksit, Mehmet; Katz, Shmuel

    2013-01-01

    We show how compact Resource Utilization Models (RUMs) can be extracted from concrete overly-detailed models of systems or sub-systems in order to model energy-aware software. Using the Counterexample-Guided Abstraction Refinement (CEGAR) approach, along with model-checking tools, abstract models

  6. Increasing Counseling Center Utilization: Yeshiva University's Experience

    Science.gov (United States)

    Schwartz, Victor; Nissel, Chaim; Eisenberg, Daniel; Kay, Jerald; Brown, Joshua T.

    2012-01-01

    Yeshiva University established a counseling center during the 2004-2005 academic year. As a religiously based institution, the administration recognized that there would likely be significant impediments to utilization of on-campus mental health services as a result of negative attitudes about mental illness and its treatment--stigma. To combat…

  7. International Students' Utilization of Counseling Services

    Science.gov (United States)

    Hwang, Bong Joo; Bennett, Robert; Beauchemin, James

    2014-01-01

    Utilization rates of counseling services by international students continue to be low despite the growing presence of this population in American colleges and universities. There are a number of adjustment factors and stressors that can have a detrimental impact on the mental health and well-being of international students, as well as a variety of…

  8. Utilizing of marketing research for marketing communication

    OpenAIRE

    Bielová, Zuzana

    2008-01-01

    The subject of bachelor's thesis "Utilizing of marketing research for marketing communication" is analyze problematic of marketing communications in sector of educational services. The aims are potential clients of education. I will try to make out import of marketing research for marketing communication of the company.

  9. utilization of sweetpotato based confection technology

    African Journals Online (AJOL)

    oma

    Three (3) states namely; Ebonyi, Enugu and Cross River states were purposively selected so as to cut across the entire agronomic and socio-cultural situations in ..... Agriculture (IITA), Ibadan, Nigeria by (CIP) International sweet potato Centre, Lima, ... Trends in Sweet potato Production Utilization and Marketing among.

  10. Increasing Counseling Center Utilization: Yeshiva University's Experience

    Science.gov (United States)

    Schwartz, Victor; Nissel, Chaim; Eisenberg, Daniel; Kay, Jerald; Brown, Joshua T.

    2012-01-01

    Yeshiva University established a counseling center during the 2004-2005 academic year. As a religiously based institution, the administration recognized that there would likely be significant impediments to utilization of on-campus mental health services as a result of negative attitudes about mental illness and its treatment--stigma. To combat…

  11. Sociodemographic characterization of ECT utilization in Hawaii.

    Science.gov (United States)

    Ona, Celia M; Onoye, Jane M; Goebert, Deborah; Hishinuma, Earl; Bumanglag, R Janine; Takeshita, Junji; Carlton, Barry; Fukuda, Michael

    2014-03-01

    Minimal research has been done on sociodemographic differences in utilization of electroconvulsive therapy (ECT) for refractory depression, especially among Asian Americans and Pacific Islanders. This study examined sociodemographic and diagnostic variables using retrospective data from Hawaii, an island state with predominantly Asian Americans and Pacific Islanders. Retrospective data were obtained from an inpatient and outpatient database of ECT patients from 2008 to 2010 at a tertiary care community hospital on O'ahu, Hawaii. There was a significant increase in overall ECT utilization from 2008 to 2009, with utilization remaining stable from 2009 to 2010. European Americans (41%) and Japanese Americans (29%) have relatively higher rates of receiving ECT, and Filipino Americans and Native Hawaiians have relatively lower rates in comparison with their population demographics. Japanese Americans received significantly more ECT procedures than European Americans. Electroconvulsive therapy is underutilized by certain sociodemographic groups that may benefit most from the treatment. There are significant differences in ECT usage based on ethnicity. Such differences may be related to help-seeking behavior, economic differences, and/or attitudes regarding mental illness. Further research is needed to elucidate the reasons for differences in utilization.

  12. Nutrient Digestion and Utilization in Farm Animals

    NARCIS (Netherlands)

    Kebreab, E.; Dijkstra, J.; Bannink, A.; Gerrits, W.J.J.; France, J.

    2006-01-01

    The purpose of this book is to present current research in modelling nutrient digestion and utilization in cattle, sheep, pigs, poultry and fish. The book is organised into six sections that cover a range of topics and modelling approaches; these are (i) absorption and passage; (ii) growth and devel

  13. Utilize Vacuum Forming to Make Interdisciplinary Connections

    Science.gov (United States)

    Love, Tyler S.; Valenza, Frank

    2011-01-01

    The concept of vacuum forming has been around since the 19th century, despite not being fully utilized in industry until the 1950s. In the past, industrial arts classes have used vacuum-forming projects to concentrate solely on the manufacturing process and the final product. However, vacuum forming is not just an old industrial arts activity; it…

  14. Social Work Science and Knowledge Utilization

    Science.gov (United States)

    Marsh, Jeanne C.; Reed, Martena

    2016-01-01

    Objective: This article advances understanding of social work science by examining the content and methods of highly utilized or cited journal articles in social work. Methods: A data base of the 100 most frequently cited articles from 79 social work journals was coded and categorized into three primary domains: content, research versus…

  15. Average utility maximization: A preference foundation

    NARCIS (Netherlands)

    A.V. Kothiyal (Amit); V. Spinu (Vitalie); P.P. Wakker (Peter)

    2014-01-01

    textabstractThis paper provides necessary and sufficient preference conditions for average utility maximization over sequences of variable length. We obtain full generality by using a new algebraic technique that exploits the richness structure naturally provided by the variable length of the sequen

  16. Cost Utility: An Aid to Decision Making.

    Science.gov (United States)

    Costa, Crist H.

    A set of procedures were developed which assist in structuring tasks and objectives in a manner to permit rational decision making. The model uses a jury of experts to rank various objectives and program processes in terms of their importance. Values are generated which relate to costs in the form of a utility-cost ratio. The model was tested in a…

  17. Utilizing the Design Charrette for Teaching Sustainability

    Science.gov (United States)

    Walker, Jason B.; Seymour, Michael W.

    2008-01-01

    Purpose: This paper aims to investigate the design charrette as a method for teaching sustainability. Design/methodology/approach: The paper utilizes a student-based design charrette for the Mississippi Gulf Coast comprising a framework for teaching sustainability. An assessment of the charrette's role in promoting sustainability in higher…

  18. China Encourages Natural Gas Development and Utilization

    Institute of Scientific and Technical Information of China (English)

    Zhou Xuehou; Jiang Shiang

    1997-01-01

    @@ China is one of the earliest nations in developing and utilizing natural gas with modern drilling technique adopted as early as in the 1940s, and the scale of the country's gas resources exploration and development has been expanded since 1950s. At the end of 1995, its yearly gas production reached 17.4 × 109 m3.

  19. Utilizing Information Technology to Facilitate Rapid Acquisition

    Science.gov (United States)

    2006-06-01

    PAGES 109 14. SUBJECT TERMS Rapid Acquisition, eCommerce , eProcurement, Information Technology, Contracting, Global Information Network...Agency. 5 eCommerce and eProcurement, and possess an adequate knowledge of information technology. D. RESEARCH QUESTIONS 1. Primary Research... eCommerce , Information Technology, and eProcurement knowledge, and government and private industry reports utilizing numerous library and Internet

  20. SAFE DELIVERY SERVICE UTILIZATION IN METEKEL ZONE,

    African Journals Online (AJOL)

    The objective of this study was to assess the status of safe delivery service utilization and ..... headache, 73(7%) severe abdominal pain, 32(3.1%) drowsiness and 28(2.7%) ..... In line with reports from Pakistan (12), mothers' knowledge about ...

  1. Resource Utilization and Productivity in IGE Schools.

    Science.gov (United States)

    Rossmiller, Richard A.; And Others

    Cost, resource utilization, and productivity were studied in 41 elementary schools using Individually Guided Education (IGE) and in 15 matched pairs of IGE and non-IGE schools. Instructional expenditures in IGE and non-IGE schools did not differ significantly. However, IGE teachers devoted significantly more time to individual instruction. A…

  2. Teacher Utilization of Instructional Consultation Teams

    Science.gov (United States)

    Berger, Jill; Yiu, Ho Lam; Nelson, Deborah; Vaganek, Megan; Rosenfield, Sylvia; Gravois, Todd; Gottfredson, Gary; Vu, Phuong; Shanahan, Kate; Hong, Vanessa

    2014-01-01

    Data regarding intervention utilization among the target population are critical to interpret evidence from efficacy trials for school-based interventions. When use of the intervention is voluntary, intervention diffusion becomes a particularly critical variable. We examined the use of Instructional Consultation Teams (IC Teams), a voluntary…

  3. Recovery and utilization of waste heat

    Energy Technology Data Exchange (ETDEWEB)

    Al-Rabghi, O.M.; Beirutty, M.; Akyurt, M.; Najjar, Y.; Alp, T. (King Abdulaziz Univ., Jeddah (Saudi Arabia). Coll. of Engineering)

    1993-09-01

    A review of waste heat recovery and utilization is presented. The potential for re-using the otherwise waste heat in different branches of industry is discussed. Traditional and new ways to recover the discharged heat from industrial equipment are illustrated. It is concluded that there exist numerous opportunities for recuperating and using waste heat. (author)

  4. Social Work Science and Knowledge Utilization

    Science.gov (United States)

    Marsh, Jeanne C.; Reed, Martena

    2016-01-01

    Objective: This article advances understanding of social work science by examining the content and methods of highly utilized or cited journal articles in social work. Methods: A data base of the 100 most frequently cited articles from 79 social work journals was coded and categorized into three primary domains: content, research versus…

  5. Molecular characterization of autochthonous hydrocarbon utilizing ...

    African Journals Online (AJOL)

    Prof. Ogunji

    Hydrocarbon utilizing bacteria in water, soil and sediment samples collected from ... oil spills to both terrestrial and aquatic environments in the past 5 decades of crude ... One of the major reasons for prolonged negative impact of oil spill on the .... in Gulf of Mexico beach sands impacted by the Deepwater Horizon oil spill.

  6. SLURM: Simplex Linux Utility for Resource Management

    Energy Technology Data Exchange (ETDEWEB)

    Jette, M; Grondona, M

    2003-04-22

    Simple Linux Utility for Resource Management (SLURM) is an open source, fault-tolerant, and highly scalable cluster management and job scheduling system for Linux clusters of thousands of nodes. Components include machine status, partition management, job management, scheduling, and stream copy modules. This paper presents an overview of the SLURM architecture and functionality.

  7. Nitrogen-fixing methane-utilizing bacteria

    NARCIS (Netherlands)

    Bont, de J.A.M.

    1976-01-01

    Methane occurs abundantly in nature. In the presence of oxygen this gas may be metabolized by bacteria that are able to use it as carbon and energy source. Several types of bacteria involved in the oxidation of methane have been described in literature. Methane-utilizing bacteria have in

  8. Light duty utility arm startup plan

    Energy Technology Data Exchange (ETDEWEB)

    Barnes, G.A.

    1998-09-01

    This plan details the methods and procedures necessary to ensure a safe transition in the operation of the Light Duty Utility Arm (LDUA) System. The steps identified here outline the work scope and identify responsibilities to complete startup, and turnover of the LDUA to Characterization Project Operations (CPO).

  9. Forest biological diversity interactions with resource utilization

    Science.gov (United States)

    S.T. Mok

    1992-01-01

    The most important forest resources of the Asia-Pacific region are the highly diverse rain forests. Utilization of the resource is a natural and inevitable consequence of the region's socio-economic development. The sustainable management and development of forest resources in the region can be achieved by implementing conservational forestry, which is based on...

  10. Maximizing Resource Utilization in Video Streaming Systems

    Science.gov (United States)

    Alsmirat, Mohammad Abdullah

    2013-01-01

    Video streaming has recently grown dramatically in popularity over the Internet, Cable TV, and wire-less networks. Because of the resource demanding nature of video streaming applications, maximizing resource utilization in any video streaming system is a key factor to increase the scalability and decrease the cost of the system. Resources to…

  11. Advance Mining of Temporal High Utility Itemset

    Directory of Open Access Journals (Sweden)

    Swati Soni

    2012-04-01

    Full Text Available The stock market domain is a dynamic and unpredictable environment. Traditional techniques, such as fundamental and technical analysis can provide investors with some tools for managing their stocks and predicting their prices. However, these techniques cannot discover all the possible relations between stocks and thus there is a need for a different approach that will provide a deeper kind of analysis. Data mining can be used extensively in the financial markets and help in stock-price forecasting. Therefore, we propose in this paper a portfolio management solution with business intelligence characteristics. We know that the temporal high utility itemsets are the itemsets with support larger than a pre-specified threshold in current time window of data stream. Discovery of temporal high utility itemsets is an important process for mining interesting patterns like association rules from data streams. We proposed the novel algorithm for temporal association mining with utility approach. This make us to find the temporal high utility itemset which can generate less candidate itemsets.

  12. Development of coal energy utilization technologies

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    Coal liquefaction produces new and clean energy by performing hydrogenation, decomposition and liquefaction on coal under high temperatures and pressures. NEDO has been developing bituminous coal liquefaction technologies by using a 150-t/d pilot plant. It has also developed quality improving and utilization technologies for liquefied coal, whose practical use is expected. For developing coal gasification technologies, construction is in progress for a 200-t/d pilot plant for spouted bed gasification power generation. NEDO intends to develop coal gasification composite cycle power generation with high efficiency and of environment harmonious type. This paper summarizes the results obtained during fiscal 1994. It also dwells on technologies to manufacture hydrogen from coal. It further describes development of technologies to manufacture methane and substituting natural gas (SNG) by hydrogenating and gasifying coal. The ARCH process can select three operation modes depending on which of SNG yield, thermal efficiency or BTX yield is targeted. With respect to promotion of coal utilization technologies, description is given on surveys on development of next generation technologies for coal utilization, and clean coal technology promotion projects. International coal utilization and application projects are also described. 9 figs., 3 tabs.

  13. 30 CFR 817.180 - Utility installations.

    Science.gov (United States)

    2010-07-01

    ... PERMANENT PROGRAM PERFORMANCE STANDARDS PERMANENT PROGRAM PERFORMANCE STANDARDS-UNDERGROUND MINING ACTIVITIES § 817.180 Utility installations. All underground mining activities shall be conducted in a manner...; oil, gas, and coal-slurry pipelines, railroads; electric and telephone lines; and water and sewage...

  14. Materials for coal conversion and utilization

    Energy Technology Data Exchange (ETDEWEB)

    1980-01-01

    The Fifth Annual Conference on Materials for Coal Conversion and Utilization was held October 7-9, 1980, at the National Bureau of Standards, Gaithersburg, Maryland. Sixty-six papers have been entered individually into ERA and EDB; two had been entered previously from other sources. (LTN)

  15. International variation in drug utilization: Antidepressant utilization in North America, Greece, and Ireland

    Directory of Open Access Journals (Sweden)

    Muhammad Mamdani

    2013-01-01

    Materials and Methods: We conducted a population-based cross-sectional time series analysis of antidepressant utilization in Canada, the United States, Greece, and Ireland from January 2007 to September 2011 using data from IMS Healthcare Inc., which tracks over 80% of global prescription sales of over 1.3 million products. We studied 23 antidepressants from five drug classes, namely, 1 serotonin-specific reuptake inhibitors (SSRIs, 2 serotonin-norepinephrine reuptake inhibitors (SNRIs, 3 tricyclic antidepressants (TCAs, 4 monoamine oxidase inhibitors (MAOIs, and 5 ′other′ antidepressants. We used time series analysis to examine trends in utilization patterns. Results: Overall antidepressant utilization increased steadily over time for all study regions, although regions differed considerably in the magnitude of antidepressant utilization and the rates of increase. While overall antidepressant utilization rates were similar between Canada (2,876 units per 1,000 population per month and the United States (2,815 units per 1,000 population per month, these rates were approximately 83% higher than in Greece (1,558 units per 1,000 population per month and approximately 50% higher than in Ireland (1,898 units per 1,000 population per month. Although the use of SSRIs, SNRIs, and other antidepressants generally increased over time, the use of TCAs and MAOIs generally decreased over time. Utilization of specific drug classes varied widely between regions, ranging from an 80% relative difference in SSRI utilization between the United States and Greece to a nearly 700% difference in the utilization of MAOIs between Canada and the United States. Conclusions: The findings of our study, using antidepressants as the case example, are consistent with previous studies demonstrating significant variation in drug utilization levels internationally. Future studies are needed to document regional variation in light of appropriateness of drug therapies to determine optimal

  16. PROBLEMS OF UTILIZATION MANUFACTURABILITY OF MACHINES

    Directory of Open Access Journals (Sweden)

    Kokorev G. D.

    2016-05-01

    Full Text Available The article contains analysis of consumption of the main natural resources and their use in the automotive industry. It is noted that during the manufacture of the car pollution is obtained in 2 times more than in exploitation. It defines the essence of recycling process (autorecycling and its ecological components. Activity on autorecycling was expressed through the index of recycling efficiency. We have analyzed the global car fleet and average annual amount of automotive waste, million tons per year. We point out that one of the economic components of recycling is the use of parts and mechanisms of machines ready for further use, by qualitative technical diagnostics with use of diagnostics devices. The problem of utilization technological effectiveness of cars as set of the properties characterizing fitness of a design to utilization at the minimum costs of time, work, means, providing the minimum negative impact on environment and the maximum involvement of components of the written-off equipment in processing or a reuse is considered. The main definitions and factors defining utilization technological effectiveness and its main indicators are given. The main ways of increasing of utilization technological effectiveness of cars are offered and the conclusion is drawn that simplifying dismantling of the car on automobile components, reducing dismantle time, time of draining of everything, the liquids and oils applied at operation, applying environmentally friendly materials, etc., the designer can increase technological effectiveness of the car at utilization. As a result of the solved task we have got ecological and economic effect of vehicle recycling

  17. Cost-utility of routine cataract surgery

    Directory of Open Access Journals (Sweden)

    Ryynänen Olli-Pekka

    2006-09-01

    Full Text Available Abstract Background If decisions on health care spending are to be as rational and objective as possible, knowledge on cost-effectiveness of routine care is essential. Our aim, therefore, was to evaluate the cost-utility of routine cataract surgery in a real-world setting. Methods Prospective assessment of health-related quality of life (HRQoL of patients undergoing cataract surgery. 219 patients (mean (SD age 71 (11 years entering cataract surgery (in 87 only first eye operated, in 73 both eyes operated, in 59 first eye had been operated earlier filled in the 15D HRQoL questionnaire before and six months after operation. Direct hospital costs were obtained from a clinical patient administration database and cost-utility analysis performed from the perspective of the secondary care provider extrapolating benefits of surgery to the remaining statistical life-expectancy of the patients. Results Mean (SD utility score (on a 0–1 scale increased statistically insignificantly from 0.82 (0.13 to 0.83 (0.14. Of the 15 dimensions of the HRQoL instrument, only seeing improved significantly after operation. Mean utility score improved statistically significantly only in patients reporting significant or major preoperative seeing problems. Of the subgroups, only those whose both eyes were operated during follow-up showed a statistically significant (p Conclusion Mean utility gain after routine cataract surgery in a real-world setting was relatively small and confined mostly to patients whose both eyes were operated. The cost of cataract surgery per quality-adjusted life year gained was much higher than previously reported and associated with considerable uncertainty.

  18. Microbial thiocyanate utilization under highly alkaline conditions.

    Science.gov (United States)

    Sorokin, D Y; Tourova, T P; Lysenko, A M; Kuenen, J G

    2001-02-01

    Three kinds of alkaliphilic bacteria able to utilize thiocyanate (CNS-) at pH 10 were found in highly alkaline soda lake sediments and soda soils. The first group included obligate heterotrophs that utilized thiocyanate as a nitrogen source while growing at pH 10 with acetate as carbon and energy sources. Most of the heterotrophic strains were able to oxidize sulfide and thiosulfate to tetrathionate. The second group included obligately autotrophic sulfur-oxidizing alkaliphiles which utilized thiocyanate nitrogen during growth with thiosulfate as the energy source. Genetic analysis demonstrated that both the heterotrophic and autotrophic alkaliphiles that utilized thiocyanate as a nitrogen source were related to the previously described sulfur-oxidizing alkaliphiles belonging to the gamma subdivision of the division Proteobacteria (the Halomonas group for the heterotrophs and the genus Thioalkalivibrio for autotrophs). The third group included obligately autotrophic sulfur-oxidizing alkaliphilic bacteria able to utilize thiocyanate as a sole source of energy. These bacteria could be enriched on mineral medium with thiocyanate at pH 10. Growth with thiocyanate was usually much slower than growth with thiosulfate, although the biomass yield on thiocyanate was higher. Of the four strains isolated, the three vibrio-shaped strains were genetically closely related to the previously described sulfur-oxidizing alkaliphiles belonging to the genus Thioalkalivibrio. The rod-shaped isolate differed from the other isolates by its ability to accumulate large amounts of elemental sulfur inside its cells and by its ability to oxidize carbon disulfide. Despite its low DNA homology with and substantial phenotypic differences from the vibrio-shaped strains, this isolate also belonged to the genus Thioalkalivibrio according to a phylogenetic analysis. The heterotrophic and autotrophic alkaliphiles that grew with thiocyanate as an N source possessed a relatively high level of cyanase

  19. Survey of electric utility demand for coal. [1972-1992; by utility and state

    Energy Technology Data Exchange (ETDEWEB)

    Asbury, J.G.; Caruso, J.V.; Kouvalis, A.; Maslowski, C.S.

    1979-08-01

    This report presents the results of a survey of electric utility demand for coal in the United States. The sources of survey information are: (1) Federal Energy Regulatory Commission Form 423 data on utility coal purchases during the period July 1972 through December 1978 and (2) direct telephone survey data on utility coal-purchase intentions for power plants to be constructed by 1992. Price and quantity data for coal used in existing plants are presented to illustrate price and market-share trends in individual coal-consuming states during recent years. Coal source, quality, quantity, and transportation data are reported for existing and planned generating plants.

  20. Overview of Steel Slag Application and Utilization

    Directory of Open Access Journals (Sweden)

    Lim J.W.

    2016-01-01

    Full Text Available Significant quantities of steel slag are generated as waste material or byproduct every day from steel industries. Slag is produced from different types of furnaces with different operating conditions. Slag contains Ferrous Oxide, Calcium Oxide, Silica etc. Physical and chemical properties of slag are affected by different methods of slag solidification such as air cooled, steam, and injection of additives. Several material characterization methods, such as X-ray Diffraction (XRD, Scanned Electron Microscopy (SEM and Inductive Coupled Plasma (ICP-OES are used to determine elemental composition in the steel slag. Therefore, slags can become one of the promising materials in various applications such as in transportation industry, construction, cement production, waste water and water treatment. The various applications of steel slag indicate that it can be reused and utilized rather than being disposed to the landfill. This paper presents a review of its applications and utilization.

  1. High-gravity brewing utilizing factorial design

    Directory of Open Access Journals (Sweden)

    R. B. Almeida

    2000-06-01

    Full Text Available A number of factors can influence the behavior of yeast during fermentation. Some of these factors (initial wort concentration, initial pH and percentage of corn syrup in the composition of the wort were studied in order to determine their influence on the productivity of fermentation. Fermentations were carried out at 25ºC utilizing a 2³ factorial design of these factors. The results showed that the percentage of corn syrup had no influence on process productivity, whereas initial pH and especially initial wort concentration did. It can be concluded that using pH and initial wort concentration values higher than those utilized in this work (5.5 and 20ºP, respectively will result in a higher productivity.

  2. Planning manual for utility application of WECS

    Energy Technology Data Exchange (ETDEWEB)

    Park, G.L. (ed.)

    1979-06-01

    A two-part approach for evaluating the feasibility of wind electric conversion systems (WECS) for utility application is presented and explained. Assessment of wind energy potential, sites, interconnection, and capital and production costing is included. The first part is a brief preliminary procedure used to determine whether the expense and effort of a detailed investigation is justified. The preliminary procedure requires assumptions which limit its accuracy. If the result indicates that WECS have probable potential for a specific utility application, then a set of modifications to detailed conventional planning procedures is developed. The modifications include discussion of wind velocity estimation and effects of site features on wind velocity, institutional problems, siting, choosing generation cases with WECS, reliability considerations, production costing, and operating problems. Appendices include an annotated bibliography, wind measurement methods, procedure for estimating WECS capacity factor, and a method for generating correlated wind velocity samples for use in production cost programs.

  3. Analysis of Comprehensive Utilization of Coconut Waste

    Institute of Scientific and Technical Information of China (English)

    Kan; ZHENG; Dong; LIANG; Xirui; ZHANG

    2013-01-01

    This paper describes and analyzes the coconut cultivation in China,and the current comprehensive utilization of waste resources generated during cultivation and processing of coconut.The wastes generated in the process of cultivation include old coconut tree trunk,roots,withered coconut leaves,coconut flower and fallen cracking coconut,mainly used for biogas extraction,direct combustion and power generation,brewing,pharmacy,and processing of building materials;the wastes generated during processing include coconut water,coconut coat,coconut shell and coconut meal,mainly used for processing beverages,pharmaceutical products,activated carbon,medium and feed.This paper analyzes and explores some problems in the process of comprehensive utilization of coconut waste in China,such as insufficient understanding,inadequate development and lack of research efforts,and finally puts forth the corresponding development countermeasures.

  4. Preparation, characterization and utilization of starch nanoparticles.

    Science.gov (United States)

    Kim, Hee-Young; Park, Sung Soo; Lim, Seung-Taik

    2015-02-01

    Starch is one of the most abundant biopolymers in nature and is typically isolated from plants in the form of micro-scale granules. Recent studies reported that nano-scale starch particles could be readily prepared from starch granules, which have unique physical properties. Because starch is environmentally friendly, starch nanoparticles are suggested as one of the promising biomaterials for novel utilization in foods, cosmetics, medicines as well as various composites. An overview of the most up-to-date information regarding the starch nanoparticles including the preparation processes and physicochemical characterization will be presented in this review. Additionally, the prospects and outlooks for the industrial utilization of starch nanoparticles will be discussed. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. Comprehensive Utilization of Complex Titania Ore

    Institute of Scientific and Technical Information of China (English)

    YUAN Zhang-fu; PAN Yi-fang; ZHOU E; XU Cong; LI Shu-qing

    2007-01-01

    To fully utilize Panzhihua titanium resources, a new process was proposed. In the process, Panzhihua ilmenite concentrate was first reduced in a rotary hearth furnace (RHF) to produce a titanium-rich material and iron. The titanium-rich material was then used in a new chlorination process to produce TiCl4. The comparison of different groups of experimental results or calculation results showed that the utilization ratio of material was improved by using the titanium-rich material after pretreatment other than low level titanic ilmenite directly and the combined fluidized beds (FTF) were more likely to reduce bed height and reaction time than the single fluidized beds (Single F or Single T) under the condition of the same chlorination conversion ratio. Finally, the influence of reduction temperature and the anti-agglomeration capacity of the combined fluidized bed was analyzed.

  6. Utilization of structural steel in buildings.

    Science.gov (United States)

    Moynihan, Muiris C; Allwood, Julian M

    2014-08-01

    Over one-quarter of steel produced annually is used in the construction of buildings. Making this steel causes carbon dioxide emissions, which climate change experts recommend be reduced by half in the next 37 years. One option to achieve this is to design and build more efficiently, still delivering the same service from buildings but using less steel to do so. To estimate how much steel could be saved from this option, 23 steel-framed building designs are studied, sourced from leading UK engineering firms. The utilization of each beam is found and buildings are analysed to find patterns. The results for over 10 000 beams show that average utilization is below 50% of their capacity. The primary reason for this low value is 'rationalization'-providing extra material to reduce labour costs. By designing for minimum material rather than minimum cost, steel use in buildings could be drastically reduced, leading to an equivalent reduction in 'embodied' carbon emissions.

  7. Microorganism Utilization for Synthetic Milk Production

    Science.gov (United States)

    Birmele, Michele; Morford, Megan; Khodadad, Christina; Spencer, Lashelle; Richards, Jeffrey; Strayer, Richard; Caro, Janicce; Hummerick, Mary; Wheeler, Ray

    2014-01-01

    A desired architecture for long duration spaceflight, such as aboard the International Space Station (ISS) or for future missions to Mars, is to provide a supply of fresh food crops for the astronauts. However, some crops can create a high proportion of inedible plant waste. The main goal of this project was to produce the components of milk (sugar, lipid, protein) from inedible plant waste by utilizing microorganisms (fungi, yeast, bacteria). Of particular interest was utilizing the valuable polysaccharide, cellulose, found in plant waste, to naturally fuel- through microorganism cellular metabolism- the creation of sugar (glucose), lipid (milk fat), and protein (casein) to produce a synthetic edible food product. Environmental conditions such as pH, temperature, carbon source, aeration, and choice microorganisms.

  8. Overview of waste heat utilization systems

    Science.gov (United States)

    Bailey, M. M.

    1984-01-01

    The heavy truck diesel engine rejects a significant fraction of its fuel energy in the form of waste heat. Historically, the Department of Energy has supported technology efforts for utilization of the diesel exhaust heat. Specifically, the Turbocompound and the Organic Rankine Cycle System (ORCS) have demonstrated that meaningful improvements in highway fuel economy can be realized through waste heat utilization. For heat recovery from the high temperature exhaust of future adiabatic diesel engines, the DOE/NASA are investigating a variety of alternatives based on the Rankine, Brayton, and Stirling power cycles. Initial screening results indicate that systems of this type offer a fuel savings advantage over the turbocompound system. Capital and maintenance cost projections, however, indicate that the alternative power cycles are not competitive on an economic payback basis. Plans call for continued analysis in an attempt to identify a cost effective configuration with adequate fuel savings potential.

  9. City growth as a resource utilization problem

    CERN Document Server

    Ghosh, Asim; Chakrabarti, Anindya S; Chakrabarti, Bikas K

    2014-01-01

    We study a resource utilization scenario characterized by intrinsic attractiveness, in a system of many restaurants where customers compete to get the best services out of many choices. Results for the case with uniform attractiveness are reported. When attractiveness is uniformly distributed, it gives rise to a Zipf-Pareto law for the number of customers. We perform an exact calculation for the utilization fraction for the case when choices are made independent of attractiveness. A variant of the model is also introduced where the attractiveness can be treated as a fitness to stay in the business. When a restaurant loses customers, its fitness is replaced by a random fitness. The fitness distribution is characterized by a power law, but the power law distribution in number of customers still holds, implying the robustness of the model. Our model serves as a paradigm for city size distribution and the emergence of Zipf law.

  10. Materials for coal conversion and utilization

    Energy Technology Data Exchange (ETDEWEB)

    None,

    1981-01-01

    The Sixth annual conference on materials for coal conversion and utilization was held October 13-15, 1981 at the National Bureau of Standards Gaithersburg, Maryland. It was sponsored by the US Department of Energy, the Electric Power Research Institute, the Gas Research Institute and the National Bureau of Standards. Fifty-eight papers from the proceedings have been entered individually into EDB and ERA; four papers had been entered previously from other sources. (LTN)

  11. Leak detection utilizing analog binaural (VLSI) techniques

    Science.gov (United States)

    Hartley, Frank T. (Inventor)

    1995-01-01

    A detection method and system utilizing silicon models of the traveling wave structure of the human cochlea to spatially and temporally locate a specific sound source in the presence of high noise pandemonium. The detection system combines two-dimensional stereausis representations, which are output by at least three VLSI binaural hearing chips, to generate a three-dimensional stereausis representation including both binaural and spectral information which is then used to locate the sound source.

  12. Broad Prospect for CBM Development and Utilization

    Institute of Scientific and Technical Information of China (English)

    Jie Mingxun; Lin Jianhao; Hu Aimei

    2006-01-01

    @@ Significance of CBM development and Utilization CBM (coal-bed methane) is the coal coexisting and associated gas resource. Influenced by the success of CBM exploration and development in the United States in the end of 1980s, China started assessment of CBM resource and exploration and development of CBM resource. However, the nation did not start the pilot CBM development on a large scale until the 21st century.

  13. Chiropractic and CAM Utilization: A Descriptive Review

    OpenAIRE

    Meeker William C; Lawrence Dana J

    2007-01-01

    Abstract Objective To conduct a descriptive review of the scientific literature examining use rates of modalities and procedures used by CAM clinicians to manage chronic LBP and other conditions Data Sources A literature of PubMed and MANTIS was performed using the key terms Chiropractic; Low Back Pain; Utilization Rate; Use Rate; Complementary and Alternative Medicine; and Health Services in various combinations. Data Selection A total of 137 papers were selected, based upon including inform...

  14. Shadow price in the power utility case

    OpenAIRE

    Attila Herczegh; Vilmos Prokaj

    2011-01-01

    We consider the problem of maximizing expected power utility from consumption over an infinite horizon in the Black–Scholes model with proportional transaction costs, as studied in Shreve and Soner [ Ann. Appl. Probab. 4 (1994) 609–692]. ¶ Similar to Kallsen and Muhle-Karbe [ Ann. Appl. Probab. 20 (2010) 1341–1358], we derive a shadow price, that is, a frictionless price process with values in the bid-ask spread which leads to the same optimal policy.

  15. Qualitative Methods in Drug Utilization Research

    DEFF Research Database (Denmark)

    Almarsdóttir, Anna Birna; Bastholm Rahmner, Pia

    2016-01-01

    Qualitative research methods derive from the social sciences. Their use in drug utilization research is increasingly widespread, especially in understanding patient and prescriber perspectives. The main focus in qualitative research is exploration of a given phenomenon in order to get a wider...... understanding of why and how it appears. Qualitative research methods build on various theoretical underpinnings/schools of thought. The same validity and quality criteria cannot be used for both qualitative and quantitative methods....

  16. GPS: Public Utility or Software Platform

    Science.gov (United States)

    2016-09-01

    media.terry.uga.edu/documents/exec_ed/bonbright/ principles_of_public_utility_rates.pdf, 3; John Black, ed., Oxford Dictionary of Economics (New York: Oxford...Coordination Office, “Control Segment;” ASD(NII), Global Positioning System Standard, 3. 234 Black, Oxford Dictionary of Economics , 380; Geddes, “Public...Tool .............................................. 11 2. GPS is an Element of American Foreign Policy, National Defense, and Economic Policy

  17. Utilizing RELAX NG Schemas in XML Editors

    OpenAIRE

    Schmied, Martin

    2008-01-01

    This thesis explores the possibilities of utilizing RELAX NG schemata in the process of editing XML documents. The ultimate goal of this thesis is to prototype a system supporting user while editing XML document with bound RELAX NG schema inside the Eclipse IDE. Such a system comprises two major components -- an integration of RELAX NG validator and an autocompletion engine. Design of the autocompletion engine represents the main contribution of this thesis, because similar systems are almost...

  18. Solar heat utilization for adsorption cooling device

    Directory of Open Access Journals (Sweden)

    Malcho Milan

    2012-04-01

    Full Text Available This article deals with possibility of solar system connection with adsorption cooling system. Waste heat from solar collectors in summer is possible to utilize in adsorption cooling systems, which desorption temperatures have to be lower than temperature of heat transport medium operation temperature. For verification of work of this system was constructed on the Department of power engineering on University of Zilina solar adsorption cooling device.

  19. SLURM: Simple Linux Utility for Resource Management

    Energy Technology Data Exchange (ETDEWEB)

    Jette, M; Dunlap, C; Garlick, J; Grondona, M

    2002-07-08

    Simple Linux Utility for Resource Management (SLURM) is an open source, fault-tolerant, and highly scalable cluster management and job scheduling system for Linux clusters of thousands of nodes. Components include machine status, partition management, job management, scheduling and stream copy modules. The design also includes a scalable, general-purpose communication infrastructure. This paper presents a overview of the SLURM architecture and functionality.

  20. Clean and Highly Efficient Utilization of Coal

    Institute of Scientific and Technical Information of China (English)

    WANG Jianguo; YANG Li

    2011-01-01

    @@ Clean and highly efficient utilization of coal is an important scientific and technological issue.As the petroleum resource decreases but its consumption increases, all of the countries in the world have to face the big issue of sustainable development of energy and economy and protection of environment.Therefore, study on clean coal technology (CCT) has attracted much attention and become one of important themes of energy research.

  1. The Utility of Ada for Army Modeling

    Science.gov (United States)

    1990-04-10

    34 Ada " for Ada Lovelace (1815-1851), a mathematician who worked with Charles Babbage on his difference and analytic engines.9 Later in 1979, the HOLWG...OF ADA FOR ARMY MODELING BY COLONEL MICHAEL L. YOCOM DISTRIBUTION STATEMENT A: Approved for publie releases distribution is unlimited. 1% LF-, EC TE...TITLE (ad Subtitle) a. TYPE OF REPORT & PERIOD COVERED The Utility of Ada for Army Modeling Individual Study Project 6 PERFORMING ORG. REPORT NUMBER

  2. Constraints to waste utilization and disposal

    Energy Technology Data Exchange (ETDEWEB)

    Steadman, E.N.; Sondreal, E.A.; Hassett, D.J.; Eylands, K.E.; Dockter, B.A. [Univ. of North Dakota, Grand Forks, ND (United States)

    1995-12-01

    The value of coal combustion by-products for various applications is well established by research and commercial practice worldwide. As engineering construction materials, these products can add value and enhance strength and durability while simultaneously reducing cost and providing the environmental benefit of reduced solid waste disposal. In agricultural applications, gypsum-rich products can provide plant nutrients and improve the tilth of depleted soils over large areas of the country. In waste stabilization, the cementitious and pozzolanic properties of these products can immobilize hazardous nuclear, organic, and metal wastes for safe and effective environmental disposal. Although the value of coal combustion by-products for various applications is well established, the full utilization of coal combustion by-products has not been realized in most countries. The reasons for the under utilization of these materials include attitudes that make people reluctant to use waste materials, lack of engineering standards for high-volume uses beyond eminent replacement, and uncertainty about the environmental safety of coal ash utilization. More research and education are needed to increase the utilization of these materials. Standardization of technical specifications should be pursued through established standards organizations. Adoption of uniform specifications by government agencies and user trade associations should be encouraged. Specifications should address real-world application properties, such as air entrainment in concrete, rather than empirical parameters (e.g., loss on ignition). The extensive environmental assessment data already demonstrating the environmental safety of coal ash by-products in many applications should be more widely used, and data should be developed to include new applications.

  3. EERC Center for Biomass Utilization 2005

    Energy Technology Data Exchange (ETDEWEB)

    Zygarlicke, C J; Schmidt, D D; Olson, E S; Leroux, K M; Wocken, C A; Aulich, T A; WIlliams, K D

    2008-07-28

    Biomass utilization is one solution to our nation’s addiction to oil and fossil fuels. What is needed now is applied fundamental research that will cause economic technology development for the utilization of the diverse biomass resources in the United States. This Energy & Environmental Research Center (EERC) applied fundamental research project contributes to the development of economical biomass utilization for energy, transportation fuels, and marketable chemicals using biorefinery methods that include thermochemical and fermentation processes. The fundamental and basic applied research supports the broad scientific objectives of the U.S. Department of Energy (DOE) Biomass Program, especially in the area of developing alternative renewable biofuels, sustainable bioenergy, technologies that reduce greenhouse gas emissions, and environmental remediation. Its deliverables include 1) identifying and understanding environmental consequences of energy production from biomass, including the impacts on greenhouse gas production, carbon emission abatement, and utilization of waste biomass residues and 2) developing biology-based solutions that address DOE and national needs related to waste cleanup, hydrogen production from renewable biomass, biological and chemical processes for energy and fuel production, and environmental stewardship. This project serves the public purpose of encouraging good environmental stewardship by developing biomass-refining technologies that can dramatically increase domestic energy production to counter current trends of rising dependence upon petroleum imports. Decreasing the nation’s reliance on foreign oil and energy will enhance national security, the economy of rural communities, and future competitiveness. Although renewable energy has many forms, such as wind and solar, biomass is the only renewable energy source that can be governed through agricultural methods and that has an energy density that can realistically compete with

  4. Waste heat utilization in industrial processes

    Science.gov (United States)

    Weichsel, M.; Heitmann, W.

    1978-01-01

    A survey is given of new developments in heat exchangers and heat pumps. With respect to practical applications, internal criteria for plant operation are discussed. Possibilities of government support are pointed out. Waste heat steam generators and waste heat aggregates for hot water generation or in some cases for steam superheating are used. The possibilities of utilization can be classified according to the economic improvements and according to their process applications, for example, gascooling. Examples are presented for a large variety of applications.

  5. Oscillatory dynamics of investment and capacity utilization

    Science.gov (United States)

    Greenblatt, R. E.

    2017-01-01

    Capitalist economic systems display a wide variety of oscillatory phenomena whose underlying causes are often not well understood. In this paper, I consider a very simple model of the reciprocal interaction between investment, capacity utilization, and their time derivatives. The model, which gives rise periodic oscillations, predicts qualitatively the phase relations between these variables. These predictions are observed to be consistent in a statistical sense with econometric data from the US economy.

  6. How do utilities respond to emergencies?

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, B. [BC Hydro, Vancouver, BC (Canada). Distribution Vegetation Management

    2006-07-01

    Trees can become problematic to utilities during storms as power companies can be held liable for injuries or damage resulting from power line contact. In addition, fallen trees and branches can impact on the reliable supply of electricity. This paper outlined BC Hydro's emergency response plan with reference to vegetation management. During severe wind, snow or ice storms, vegetation coordinators and contractor crews are mobilized to assist with the removal of trees that have fallen on power lines. Circuits are prioritized according to their essential services such as hospitals, followed by areas where there are the largest numbers of customers without services. Trees accounted for 9,733 of the 18, 122 outages over the last 4.5 years in BC Hydro's distribution system alone. Estimated costs of repair for tree-caused damages were approximately $15 million. Trees can bring power lines down, break poles or cross arms, and fall across roads, blocking access to response crews. Recovery from storm damage can go on for many years following the event. Trees contacting power lines can also be a source of ignition, creating the potential for wildfires caused by line contact. Protection of the public from power line hazards is the responsibility of every utility, which is why utilities often press for adequate clearances and hazard tree removals as part of their basic programs. It was concluded that appropriate planting can be a huge factor in mitigating risks for power line contact.

  7. Calculating cost savings in utilization management.

    Science.gov (United States)

    MacMillan, Donna

    2014-01-01

    A major motivation for managing the utilization of laboratory testing is to reduce the cost of medical care. For this reason it is important to understand the basic principles of cost accounting in the clinical laboratory. The process of laboratory testing includes three distinct components termed the pre-analytic, analytic and post-analytic phases. Utilization management efforts may impact the cost structure of these three phases in different ways depending on the specific details of the initiative. Estimates of cost savings resulting from utilization management programs reported in the literature have often been fundamentally flawed due to a failure to understand basic concepts such as the difference between laboratory costs versus charges and the impact of reducing laboratory test volumes on the average versus marginal cost structure in the laboratory. This article will provide an overview of basic cost accounting principles in the clinical laboratory including both job order and process cost accounting. Specific examples will be presented to illustrate these concepts in various different scenarios.

  8. Continuous utility factor in segregation models

    Science.gov (United States)

    Roy, Parna; Sen, Parongama

    2016-02-01

    We consider the constrained Schelling model of social segregation in which the utility factor of agents strictly increases and nonlocal jumps of the agents are allowed. In the present study, the utility factor u is defined in a way such that it can take continuous values and depends on the tolerance threshold as well as the fraction of unlike neighbors. Two models are proposed: in model A the jump probability is determined by the sign of u only, which makes it equivalent to the discrete model. In model B the actual values of u are considered. Model A and model B are shown to differ drastically as far as segregation behavior and phase transitions are concerned. In model A, although segregation can be achieved, the cluster sizes are rather small. Also, a frozen state is obtained in which steady states comprise many unsatisfied agents. In model B, segregated states with much larger cluster sizes are obtained. The correlation function is calculated to show quantitatively that larger clusters occur in model B. Moreover for model B, no frozen states exist even for very low dilution and small tolerance parameter. This is in contrast to the unconstrained discrete model considered earlier where agents can move even when utility remains the same. In addition, we also consider a few other dynamical aspects which have not been studied in segregation models earlier.

  9. Premature Ejaculation and Utilization of Cognitive Techniques

    Directory of Open Access Journals (Sweden)

    Serkan AKKOYUNLU

    2013-03-01

    Full Text Available Introduction: Premature ejaculation is the most common male sexual dysfunction leading to distress in many couples. Master and Johnson emphasized the concept of early learned experiences and Kaplan emphasized lack of sensory awareness. For treatment sex therapists mainly utilize start-stop and squeeze techniques as homework. Couples enter sex therapy with some cognitive distortions and beliefs about sex and sexuality. These beliefs are also named sexual myths. For some couples using techniques to challenge cognitive distortions and maladaptive beliefs about sex and sexuality can be used. In this paper by presenting a case we discussed how cognitive techniques can be used along with behaviour techniques with couples. Case: Presenting clients are five years married couple who are thirty and twenty nine years old respectively. They attended to the outpatient clinic with the request of the female client. Their main complaint was premature ejaculation. They were diagnosed premature ejaculation using clinical interview. In treatment besides start and stop technique, cognitive techniques were utilized to address dysfunctional beliefs about sexuality. Discussion: Premature ejaculation is a male sexual dysfunction that causes distress and intimacy problems between couples. Stop start and squeeze techniques were accepted as the choice of treatment but their effectiveness is questioned recently. Also cognitive distortions and maladaptive beliefs may hamper therapy progress. Besides that, behavioral techniques utilizing cognitive techniques to lessen the degree of dysfunctional beliefs about sex and sexuality may help the couple to overcome premature ejaculation and enhance sexual satisfaction and intimacy.

  10. Futility has no utility in resuscitation medicine.

    Science.gov (United States)

    Ardagh, M

    2000-10-01

    "Futility" is a word which means the absence of benefit. It has been used to describe an absence of utility in resuscitation endeavours but it fails to do this. Futility does not consider the harms of resuscitation and we should consider the balance of benefit and harm that results from our resuscitation endeavours. If a resuscitation is futile then any harm that ensues will bring about an unfavourable benefit/harm balance. However, even if the endeavour is not futile, by any definition, the benefit/harm balance may still be unfavourable if the harms that ensue are great. It is unlikely that we will ever achieve a consensus definition of futility and certainly not one that is applicable to every patient undergoing resuscitation. In the meantime our use of the term "futile", in the mistaken belief that it tells us whether it is worth resuscitating or not, has no utility as it will never succeed in telling us this. Furthermore we risk causing offence by use of the term and we risk harming the patient's autonomy by using futility as an overriding force. Instead we should consider the utility of our endeavours, for which an assessment of the harms of resuscitation should be added to our considerations of its benefit. This balance of benefit and harm should then be evaluated as best it can be from the patient's perspective. The words futile and futility should be abandoned by resuscitationists.

  11. Coupling hydrogen fuel and carbonless utilities

    Energy Technology Data Exchange (ETDEWEB)

    Berry, G.D. [Lawrence Livermore National Lab., CA (United States)

    1998-08-01

    A number of previous analyses have focused on comparisons of single hydrogen vehicles to petroleum and alternative fuel vehicles or of stationary hydrogen storage for utility or local power applications. LLNL`s approach is to compare combined transportation/utility storage systems using hydrogen and fossil fuels. Computer models have been constructed to test the hypothesis that combining carbonless electricity sources and vehicles fueled by electrolytic hydrogen can reduce carbon emissions more cost effectively than either approach alone. Three scenarios have been developed and compared using computer simulations, hourly utility demand data, representative data for solar and wind energy sites, and the latest available EIA projections for transportation and energy demand in the US in 2020. Cost projections were based on estimates from GRI, EIA, and a recent DOE/EPRI report on renewable energy technologies. The key question guiding this analysis was: what can be gained by combining hydrogen fuel production and renewable electricity? Bounding scenarios were chosen to analyze three carbon conscious options for the US transportation fuel and electricity supply system beyond 2020: Reference Case -- petroleum transportation and natural gas electric sector; Benchmark Case -- petroleum transportation and carbonless electric sector; and Target Case -- hydrogen transportation and carbonless electric sector.

  12. Utilization of thermal effects for silicon photonics

    Science.gov (United States)

    Dai, Daoxin; Yu, Longhai; Chen, Sitao; Wu, Hao

    2015-08-01

    Thermal effect plays a key role and has been utilized for various photonic devices. For silicon photonics, the thermal effect is usually important because of the large thermo-optical coefficient of silicon material. This paper gives a review for the utilization of thermal effects for silicon photonics. First, the thermal effect is very beneficial to realize energy-efficient silicon photonic devices with tunability/switchability (including switches, variable optical attenuators, etc). Traditionally metal micro-heater sitting on a buried silicon-on-insulator (SOI) nanowire is used to introduce a phase shift for thermal tunability by injecting a electrical current. An effective way to improve the energy-efficiency of thermal tuning is reducing the volume of the optical waveguide as well as the micro-heater. Our recent work on silicon nanophotonic waveguides with novel nano-heaters based on metal wires as well as graphene ribbons will be summarized. Second, the thermal resistance effect of the metal strip on a hybrid plasmonic waveguide structure can be utilized to realize an ultra-small on-chip photodetector available for an ultra-broad band of wavelength, which will also be discussed.

  13. Review of Energy Harvesters Utilizing Bridge Vibrations

    Directory of Open Access Journals (Sweden)

    Farid Ullah Khan

    2016-01-01

    Full Text Available For health monitoring of bridges, wireless acceleration sensor nodes (WASNs are normally used. In bridge environment, several forms of energy are available for operating WASNs that include wind, solar, acoustic, and vibration energy. However, only bridge vibration has the tendency to be utilized for embedded WASNs application in bridge structures. This paper reports on the recent advancements in the area of vibration energy harvesters (VEHs utilizing bridge oscillations. The bridge vibration is narrowband (1 to 40 Hz with low acceleration levels (0.01 to 3.8 g. For utilization of bridge vibration, electromagnetic based vibration energy harvesters (EM-VEHs and piezoelectric based vibration energy harvesters (PE-VEHs have been developed. The power generation of the reported EM-VEHs is in the range from 0.7 to 1450000 μW. However, the power production by the developed PE-VEHs ranges from 0.6 to 7700 μW. The overall size of most of the bridge VEHs is quite comparable and is in mesoscale. The resonant frequencies of EM-VEHs are on the lower side (0.13 to 27 Hz in comparison to PE-VEHs (1 to 120 Hz. The power densities reported for these bridge VEHs range from 0.01 to 9539.5 μW/cm3 and are quite enough to operate most of the commercial WASNs.

  14. Utilities and energy efficiency Denmark report

    Energy Technology Data Exchange (ETDEWEB)

    Olesen, G.B.; Lyck, N.C.

    1996-11-01

    The report is the Danish contribution to the project `Utilities and Energy Efficiency` produced for the European Commission by IET, Nikkel straat 15, 4823 AE Breda, The Netherlands. Information is given under the headings of existing situation and desired situation. Recommendations are also given under the headings of legislation concerning the objectives of the utilities, of government programs and targets, of organizational structure, required market dependence and internal objectives of the utilities, for regulation and standardization, and of tariff structure. Flow diagrams are presented for the Danish energy system 1990, 1993. The 1993 follow up of the energy plan `Energy 2000` points out that the goals set up at that time, first and foremost the 20% reduction in CO{sub 2} emissions in 2005 compared to the 1988 level, will not be reached without changes in policy, such as an increase in the use of renewable energy, more transparent and consistent tariff systems as a greater incentive for energy conservation, regulations on thermal insulation of houses, increase in public information activities,a new subsidy scheme to stimulate improvements of energy efficiency in buildings and regulations on energy supply to large buildings. (ARW) 55 refs.

  15. X-31A Tactical Utility Flight Testing

    Science.gov (United States)

    Friehmelt, Holger; Guetter, Richard; Kim, Quirin

    1997-01-01

    The two X-31A were jointly built by Daimler-Benz Aerospace AG and Rockwell International. These German-American experimental aircraft were designed to explore the new realm of flight far beyond stall by employing advanced technologies like thrust vectoring and sophisticated flight control systems. The X-31A aircraft is equipped with a thrust vectoring system consisting of three aft mounted paddles to deflect the thrust vector in both pitch and yaw axes, thus providing the X-31A in this 'Enhanced Fighter Maneuverability program with an agility and maneuverability never seen before. The tactical utility of the X-31A using post stall technologies has been revealed in an extensive flight test campaign against various current state-of-the-art fighter aircraft in a close-in combat arena. The test philosophy included both simulation and flight test. The tremendous tactical advantage of the X-31A during the tactical utility evaluation flight test phase was accompanied by a deepened insight into post stall tactics its typical maneuvers, impacts on pilot-aircraft interfaces and requirements for future weapons to both engineers and the military community. Some selected aspects of the tactical utility of the X-31A using post stall technologies unveiled by the International Test Organization are presented here.

  16. The Rate of Oxygen Utilization by Cells

    Science.gov (United States)

    Wagner, Brett A.; Venkataraman, Sujatha; Buettner, Garry R.

    2011-01-01

    The discovery of oxygen is considered by some to be the most important scientific discovery of all time – from both physical-chemical/astrophysics and biology/evolution viewpoints. One of the major developments during evolution is the ability to capture dioxygen in the environment and deliver it to each cell in the multicellular, complex mammalian body -- on demand, i.e. just-in-time. Humans use oxygen to extract approximately 2550 Calories (10.4 MJ) from food to meet daily energy requirements. This combustion requires about 22 moles of dioxygen per day, or 2.5 × 10-4 mol s-1. This is an average rate of oxygen utilization of 2.5 × 10-18 mol cell-1 s-1, i.e. 2.5 amol cell-1 s-1. Cells have a wide range of oxygen utilization, depending on cell type, function, and biological status. Measured rates of oxygen utilization by mammalian cells in culture range from 350 amol cell-1 s-1. There is a loose positive linear correlation of the rate of oxygen consumption (OCR) by mammalian cells in culture with cell volume and cell protein. The use of oxygen by cells and tissues is an essential aspect of the basic redox biology of cells and tissues. This type of quantitative information is fundamental to investigations in quantitative redox biology, especially redox systems biology. PMID:21664270

  17. Utility Optimal Scheduling in Processing Networks

    CERN Document Server

    Huang, Longbo

    2010-01-01

    We consider the problem of utility optimal scheduling in general \\emph{processing networks} with random arrivals and network conditions. These are generalizations of traditional data networks where commodities in one or more queues can be combined to produce new commodities that are delivered to other parts of the network. This can be used to model problems such as in-network data fusion, stream processing, and grid computing. Scheduling actions are complicated by the \\emph{underflow problem} that arises when some queues with required components go empty. In this paper, we develop the Perturbed Max-Weight algorithm (PMW) to achieve optimal utility. The idea of PMW is to perturb the weights used by the usual Max-Weight algorithm to ``push'' queue levels towards non-zero values (avoiding underflows). We show that when the perturbations are carefully chosen, PMW is able to achieve a utility that is within $O(1/V)$ of the optimal value for any $V\\geq1$, while ensuring an average network backlog of $O(V)$.

  18. Utilization of cryopreserved semen in tumor patients.

    Science.gov (United States)

    Krause, W; Brake, A

    1994-01-01

    Treatment with cytotoxic drugs or with radiation in order to manage a tumor or another life-threatening disease involves a potential hazard to male fertility. In these cases cryopreservation of semen is recommended. However, the number of patients requesting the subsequent insemination of their partner is rather low. It would be of interest if patients with a high probability for desiring use of the cryodeposit for insemination could be identified. During the years 1985-1992 we performed cryopreservation in 29 patients attending our department. One year following cryopreservation the utilization of the cryodeposit was analyzed: 29 patients were not interested in further maintenance, 2 patients died, 3 patients requested use for insemination, 31 patients decided to maintain the semen further in a commercial cryobank, 17 patients had a complete restitution of spermatogenesis within the observation period. In 7 patients the interval is yet below 1 year. The different modes of utilizing the cryodeposit were analyzed in relation to the semen quality, age, status, kind of disease and primary treatment. None of these factors possibly influencing the utilization showed differences between the groups. We conclude that it is impossible to predict the probability of the use of a cryodeposit of semen based on the examined patient characteristics at the time of preservation. We plan to further on offer semen preservation to all patients requiring it in a situation of threatened fertility, bearing in mind that the relative costs of the cryopreservation are low.

  19. Asteroid exploration and utilization: The Hawking explorer

    Science.gov (United States)

    Carlson, Alan; Date, Medha; Duarte, Manny; Erian, Neil; Gafka, George; Kappler, Peter; Patano, Scott; Perez, Martin; Ponce, Edgar; Radovich, Brian

    1991-01-01

    The Earth is nearing depletion of its natural resources at a time when human beings are rapidly expanding the frontiers of space. The resources which may exist on asteroids could have enormous potential for aiding and enhancing human space exploration as well as life on Earth. With the possibly limitless opportunities that exist, it is clear that asteroids are the next step for human existence in space. This report comprises the efforts of NEW WORLDS, Inc. to develop a comprehensive design for an asteroid exploration/sample return mission. This mission is a precursor to proof-of-concept missions that will investigate the validity of mining and materials processing on an asteroid. Project STONER (Systematic Transfer of Near Earth Resources) is based on two utilization scenarios: (1) moving an asteroid to an advantageous location for use by Earth; and (2) mining an asteroids and transporting raw materials back to Earth. The asteroid explorer/sample return mission is designed in the context of both scenarios and is the first phase of a long range plane for humans to utilize asteroid resources. The report concentrates specifically on the selection of the most promising asteroids for exploration and the development of an exploration scenario. Future utilization as well as subsystem requirements of an asteroid sample return probe are also addressed.

  20. Meeting processing challenges in clean coal utilization

    Energy Technology Data Exchange (ETDEWEB)

    Chugh, Y.P.; Patwardhan, A.; Barnwal, J.P. [Southern Illinois University, Carbondale, IL (United States). Dept. of Mining and Mineral Resources Engineering

    2003-02-01

    The paper identifies some of the major challenges facing processing for clean coal utilization today. Some of the ongoing research at Southern Illinois University in the areas of plant optimization, fine coal cleaning and dewatering, fine coal-water slurry combustion, development of multiple products and mine-mouth utilization for lower grade products, and co-management of coal processing wastes and coal combustion byproducts underground, or as a cover material suitable for vegetation in surface mine reclamation is approaching commercialization. Additional research has been initiated recently in low cost desulfurization for SOx reduction, and/or reducing scrubbing costs. An integrated approach to evaluating processing unit operation for enhancing overall profitability of a mining complex is paying dividends. The approach is a good tool to assess role of processing for clean coal utilization in any setting. The authors have attempted to demonstrate its use for Indian coals. They plan to develop a computer program for making this integrated assessment approach more user friendly. 33 refs., 4 figs., 10 tabs.

  1. Industrial utilization of geopressured geothermal energy

    Energy Technology Data Exchange (ETDEWEB)

    Underhill, Gary K; Carlson, Ronald A.; Clendinning, William A.; Erdos, Jozsef; Gault, John; Hall, James W.; Jones, Robert L.; Michael, Herbert K.; Powell, Paul H.; Riemann, Carl F.; Rios-Castellon, Lorenzo; Shepherd, Burchard P.; Wilson, John S.

    1976-01-01

    Discussion of the industrial utilization of geopressured geothermal energy is currently limited by the limited knowledge of the resource's distribution. However, the resource assessment activity in the Bureau of Economic Geology, The University of Texas at Austin, has identified a number of fairway or potential resource zones. These zones are located in Kenedy County; in and about Corpus Christi and Nueces Bays in Nueces, San Patricio, and Aransas Counties; in the coastal zones of Matagorda County; and in a crescent-shaped zone parallel to the coastline in Brazoria and Galveston Counties. The Kenedy and Matagorda County zones are situated in rural areas with little or no industrial activity. The Corpus Christi and Brazoria-Galveston zones are in and adjacent to highly industrialized and urbanized districts. The rural zones will require the establishment of new industries for geothermal fluid utilization while the industrial-urban zones will require either new industry, expansion to existing industry, or modification to existing plant and process. Proposed industries for geothermal fluid utilization can be considered with respect to fitting the industry to the available fluids; this has been the usual approach. An alternate approach is to fit the abailable fluids to the proposed industry. In order to follow the alternate approach requires consideration of ways to upgrade the quality of existing geothermal fluids or geothermal-derived or -energized fluids.

  2. Children with intellectual disability and hospice utilization.

    Science.gov (United States)

    Lindley, Lisa C; Colman, Mari Beth; Meadows, John T

    2017-02-01

    Over 42,000 children die each year in the United States, including those with intellectual disability (ID). Survival is often reduced when children with intellectual disability also suffer from significant motor dysfunction, progressive congenital conditions, and comorbidities. Yet, little is known about hospice care for children with intellectual disability. The purpose of this study was to explore the relationship between intellectual disability and hospice utilization. Additionally, we explored whether intellectual disability combined with motor dysfunction, progressive congenital conditions, and comorbidities influenced pediatric hospice utilization. Using a retrospective cohort design and data from the 2009 to 2010 California Medicaid claims files, we conducted a multivariate analysis of hospice utilization. This study shows that intellectual disability was negatively related to hospice enrollment and length of stay. We also found that when children had both intellectual disability and comorbidities, there was a positive association with enrolling in hospice care. A number of clinical implications can be drawn from the study findings that hospice and palliative care nurses use to improve their clinical practice of caring for children with ID and their families at end of life.

  3. Mechanisms of heme utilization by Francisella tularensis.

    Directory of Open Access Journals (Sweden)

    Helena Lindgren

    Full Text Available Francisella tularensis is a highly virulent facultative intracellular pathogen causing the severe disease tularemia in mammals. As for other bacteria, iron is essential for its growth but very few mechanisms for iron acquisition have been identified. Here, we analyzed if and how F. tularensis can utilize heme, a major source of iron in vivo. This is by no means obvious since the bacterium lacks components of traditional heme-uptake systems. We show that SCHU S4, the prototypic strain of subspecies tularensis, grew in vitro with heme as the sole iron source. By screening a SCHU S4 transposon insertion library, 16 genes were identified as important to efficiently utilize heme, two of which were required to avoid heme toxicity. None of the identified genes appeared to encode components of a potential heme-uptake apparatus. Analysis of SCHU S4 deletion mutants revealed that each of the components FeoB, the siderophore system, and FupA, contributed to the heme-dependent growth. In the case of the former two systems, iron acquisition was impaired, whereas the absence of FupA did not affect iron uptake but led to abnormally high binding of iron to macromolecules. Overall, the present study demonstrates that heme supports growth of F. tularensis and that the requirements for the utilization are highly complex and to some extent novel.

  4. Web users’ language utilization behaviors in China

    Institute of Scientific and Technical Information of China (English)

    LAI; Maosheng; QU; Peng; ZHAO; Kang

    2009-01-01

    The paper focuses on the habits of China Web users’language utilization behaviors in accessing the Web.It also seeks to make a general study on the basic nature of language phenomenon with regard to digital accessing.A questionnaire survey was formulated and distributed online for these research purposes.There were 1,267 responses collected.The data were analyzed with descriptive statistics,Chi-square testing and contingency table analyses.Results revealed the following findings.Tagging has already played an important role in Web2.0 communication for China’s Web users.China users rely greatly on all kinds of taxonomies in browsing and have also an awareness of them in effective searching.These imply that the classified languages in digital environment may aid Chinese Web users in a more satisfying manner.Highly subject-specific words,especially those from authorized tools,yielded better results in searching.Chinese users have high recognition for related terms.As to the demographic aspect,there is little difference between different genders in the utilization of information retrieval languages.Age may constitute a variable element to a certain degree.Educational background has a complex effect on language utilizations in searching.These research findings characterize China Web users’behaviors in digital information accessing.They also can be potentially valuable for the modeling and further refinement of digital accessing services.

  5. Adaptable formations utilizing heterogeneous unmanned systems

    Science.gov (United States)

    Barnes, Laura E.; Garcia, Richard; Fields, MaryAnne; Valavanis, Kimon

    2009-05-01

    This paper addresses the problem of controlling and coordinating heterogeneous unmanned systems required to move as a group while maintaining formation. We propose a strategy to coordinate groups of unmanned ground vehicles (UGVs) with one or more unmanned aerial vehicles (UAVs). UAVs can be utilized in one of two ways: (1) as alpha robots to guide the UGVs; and (2) as beta robots to surround the UGVs and adapt accordingly. In the first approach, the UAV guides a swarm of UGVs controlling their overall formation. In the second approach, the UGVs guide the UAVs controlling their formation. The unmanned systems are brought into a formation utilizing artificial potential fields generated from normal and sigmoid functions. These functions control the overall swarm geometry. Nonlinear limiting functions are defined to provide tighter swarm control by modifying and adjusting a set of control variables forcing the swarm to behave according to set constraints. Formations derived are subsets of elliptical curves but can be generalized to any curvilinear shape. Both approaches are demonstrated in simulation and experimentally. To demonstrate the second approach in simulation, a swarm of forty UAVs is utilized in a convoy protection mission. As a convoy of UGVs travels, UAVs dynamically and intelligently adapt their formation in order to protect the convoy of vehicles as it moves. Experimental results are presented to demonstrate the approach using a fully autonomous group of three UGVs and a single UAV helicopter for coordination.

  6. Development of technologies for utilizing geothermal energy

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    In verifying the effectiveness of the deep geothermal resource exploration technology, development is being carried out on a fracture-type reservoir exploration method. The seismic exploration method investigates detailed structures of underground fracture systems by using seismic waves generated on the ground surface. Verification experiments for fiscal 1994 were carried out by selecting the Kakkonda area in which small fracture networks form reservoir beds. Geothermal resources in deep sections (deeper than 2000 m with temperatures higher than 350{degree}C) are promising in terms of amount of the resources, but anticipated with difficulty in exploration and impediments in drilling. To avoid these risks, studies are being progressed on the availability of resources in deep sections, their utilization possibility, and technologies of effective exploration and drilling. This paper summarizes the results of deep resource investigations during fiscal 1994. It also describes such technological development as hot water utilizing power generation. Development is performed on a binary cycle power generation plant which pumps and utilizes hot water of 150 to 200{degree}C by using a downhole pump. The paper also reports development on element technologies for hot rock power generation systems. It also dwells on development of safe and effective drilling and production technologies for deep geothermal resources.

  7. Integrated concurrent utilization quality review, Part one.

    Science.gov (United States)

    Caterinicchio, R P

    1987-01-01

    This article is the first of a two-part series which argues for the concurrent management of the appropriateness, necessity, and quality of patient care. Intensifying scrutiny by the credentialing groups, the PROs and all third-party payors underscores the vital need to implement cost-effective information systems which integrate the departmentalized functions of patient-physician profiling, DRG case-mix analyses, length of stay monitoring, pre-admission/admission and continued stay review, discharge planning, risk management, incident reporting and quality review. In the domain of physician performance regarding admitting and practice patterns, the ability to exercise concurrent utilization-quality review means early detection and prevention of events which would otherwise result in denials of payment and/or compromised patient care. Concurrent utilization-quality review must, by definition, be managerially invasive and focused; hence, it is integral to maintaining the integrity of the services and product lines offered by the provider. In fact, if PPO status is a marketing agenda, then the institutional objectives of cost-effectiveness, productivity, value, and competitiveness can only be achieved through concurrent utilization-quality review.

  8. The Efficient Utilization of Open Source Information

    Energy Technology Data Exchange (ETDEWEB)

    Baty, Samuel R. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Intelligence and Systems Analysis

    2016-08-11

    These are a set of slides on the efficient utilization of open source information. Open source information consists of a vast set of information from a variety of sources. Not only does the quantity of open source information pose a problem, the quality of such information can hinder efforts. To show this, two case studies are mentioned: Iran and North Korea, in order to see how open source information can be utilized. The huge breadth and depth of open source information can complicate an analysis, especially because open information has no guarantee of accuracy. Open source information can provide key insights either directly or indirectly: looking at supporting factors (flow of scientists, products and waste from mines, government budgets, etc.); direct factors (statements, tests, deployments). Fundamentally, it is the independent verification of information that allows for a more complete picture to be formed. Overlapping sources allow for more precise bounds on times, weights, temperatures, yields or other issues of interest in order to determine capability. Ultimately, a "good" answer almost never comes from an individual, but rather requires the utilization of a wide range of skill sets held by a team of people.

  9. Geriatric Homelessness: Association with Emergency Department Utilization

    Science.gov (United States)

    Hategan, Ana; Tisi, Daniel; Abdurrahman, Mariam; Bourgeois, James A.

    2016-01-01

    Background Homeless adults frequently use emergency departments (EDs), yet previous studies investigating ED utilization by the older segment received little attention. This study sought to characterize older homeless adults who utilized local urban EDs. Methods ED encounters at three hospitals in Hamilton (Ont.) were analyzed, and demographic and clinical characteristics of the older homeless (age > 50) vs. younger counterparts (age ≤ 50) were compared during a 24-month period. Results Of all adults, 1,330 were homeless, of whom 66% were above age 50. Older homeless adults sought less acute care within 30 days from an index visit compared with their younger counterparts. Non-acute illnesses constituted only 18% of triaged cases. Older homeless women with access to a primary care physician (PCP) were 3.3 times more likely to return to ED within 30 days, whereas older homeless men (irrespective of PCP access) were less likely to return to ED. Conclusions Despite high homeless patient acuity, a lesser number of ED visits with increasing age remains concerning because of previously reported high morbidity and mortality rates. Access to primary care may not be enough to reduce ED utilization. Further research is needed to evaluate acute care interventions and their effectiveness in ED, and to identify homeless patients requiring more targeted services. PMID:28050223

  10. Utilities:Other:Telephone Lines at Pipe Spring National Monument, Arizona (Utilities.gdb:Other:telephone)

    Data.gov (United States)

    National Park Service, Department of the Interior — This feature class represent telephone lines at Pipe Spring National Monument, Arizona. The utility pipelines were collected by a Trimble GeoXT GPS unit with...

  11. Exploring utility function in utility management: an evaluating method of library preservation.

    Science.gov (United States)

    Yan, Bin; Shi, Feng; Yu, Rui-Qiang

    2013-12-01

    In order to seek a new method of book evaluation and realize book resources sharing among the regional university libraries, we think that library should collect books of the high utility value in the case of limited funds. We proposed a changing Bellman equation as a utility function and used the explicit functions of the book usage factor and the book usage half-life derived from the utility function as an evaluating method of the collecting books. The results from empirical data given some conclusions such as the varieties diversity, the collected risk, the tendencies of reading varieties, species continuity and so on and a librarian can use the utility management to supplement the collections management.

  12. Realistic utility versus game utility: a proposal for dealing with the spread of uncertain prospects

    Directory of Open Access Journals (Sweden)

    Benito Vittorio Frosini

    2013-05-01

    Full Text Available The author develops the properties and implications of a proposal, concerning a summary statistic of the random prospect of utilities. Following a suggestion of Allais, such a statistic is increasing with expected utility, and decreasing – for most people, who are risk averse – with the mean absolute deviation of utilities; a parameter multiplying this disper sion measure allows for risk averse or risk prone behaviour, according to its sign, and also for more or less departure from a certain prospect. It is demonstrated that this statistic (a satisfies the first stochastic dominance, (b satisfies the independence condition, (c satisfies the so called “problem of probabilistic insurance”, (d resolves the paradoxes of Allais, Ellsberg and Kahneman-Tversky (paradox of the substitution axiom, (e is compatible with Quiggin’s approach of rank-dependent expected utility models, (f the mean absolute deviation cannot be replaced by the standard deviation

  13. Utilities:Power:Underground Powerlines at Pipe Spring National Monument, Arizona (Utilities.gdb:Power:powerln)

    Data.gov (United States)

    National Park Service, Department of the Interior — This feature class represents the powerlines at Pipe Spring National Monument, Arizona. The utility pipelines were collected by a Trimble GeoXT GPS unit with...

  14. Clinical utility of measures of breathlessness.

    Science.gov (United States)

    Cullen, Deborah L; Rodak, Bernadette

    2002-09-01

    The clinical utility of measures of dyspnea has been debated in the health care community. Although breathlessness can be evaluated with various instruments, the most effective dyspnea measurement tool for patients with chronic lung disease or for measuring treatment effectiveness remains uncertain. Understanding the evidence for the validity and reliability of these instruments may provide a basis for appropriate clinical application. Evaluate instruments designed to measure breathlessness, either as single-symptom or multidimensional instruments, based on psychometrics foundations such as validity, reliability, and discriminative and evaluative properties. Classification of each dyspnea measurement instrument will recommend clinical application in terms of exercise, benchmarking patients, activities of daily living, patient outcomes, clinical trials, and responsiveness to treatment. Eleven dyspnea measurement instruments were selected. Each instrument was assessed as discriminative or evaluative and then analyzed as to its psychometric properties and purpose of design. Descriptive data from all studies were described according to their primary patient application (ie, chronic obstructive pulmonary disease, asthma, or other patient populations). The Borg Scale and the Visual Analogue Scale are applicable to exertion and thus can be applied to any cardiopulmonary patient to determine dyspnea. All other measures were determined appropriate for chronic obstructive pulmonary disease, whereas the Shortness of Breath Questionnaire can be applied to cystic fibrosis and lung transplant patients. The most appropriate utility for all instruments was measuring the effects on activities of daily living and for benchmarking patient progress. Instruments that quantify function and health-related quality of life have great utility for documenting outcomes but may be limited as to documenting treatment responsiveness in terms of clinically important changes. The dyspnea

  15. The Flexible Solar Utility. Preparing for Solar's Impacts to Utility Planning and Operations

    Energy Technology Data Exchange (ETDEWEB)

    Sterling, John [Solar Electric Power Association (SEPA), Washington, DC (United States); Davidovich, Ted [Solar Electric Power Association (SEPA), Washington, DC (United States); Cory, Karlynn [National Renewable Energy Lab. (NREL), Golden, CO (United States); Aznar, Alexandra [National Renewable Energy Lab. (NREL), Golden, CO (United States); McLaren, Joyce [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-09-01

    This paper seeks to provide a flexible utility roadmap for identifying the steps that need to be taken to place the utility in the best position for addressing solar in the future. Solar growth and the emergence of new technologies will change the electric utility of tomorrow. Although not every utility, region, or market will change in the same way or magnitude, developing a path forward will be needed to reach the Electric System of the Future in the coming decades. In this report, a series of potential future states are identified that could result in drastically different energy mixes and profiles: 1) Business as Usual, 2) Low Carbon, Centralized Generation, 3) Rapid Distributed Energy Resource Growth, 4) Interactivity of Both the Grid and Demand, and 5) Grid or Load Defection. Complicating this process are a series of emerging disruptions; decisions or events that will cause the electric sector to change. Understanding and preparing for these items is critical for the transformation to any of the future states to be successful. Predicting which future state will predominate 15 years from now is not possible; however, utilities still will need to look ahead and try to anticipate how factors will impact their planning, operations, and business models. In order to dig into the potential transformations facing the utility industry, the authors conducted a series of utility interviews, held a working session at a major industry solar conference, and conducted a quantitative survey. To focus conversations, the authors leveraged the Rapid Distributed Energy Resource (DER) Growth future to draw out how utilities would have to adapt from current processes and procedures in order to manage and thrive in that new environment. Distributed solar was investigated specifically, and could serve as a proxy resource for all distributed generation (DG). It can also provide the foundation for all DERs.

  16. 26 CFR 1.42-10 - Utility allowances.

    Science.gov (United States)

    2010-04-01

    ... using the HUD Utility Schedule Model under paragraph (b)(4)(ii)(D) of this section, or a cost estimate... utility company providing the estimated cost of that utility for a unit of similar size and construction... per-unit cost of the utilities for units of similar size and construction for the geographic area...

  17. 48 CFR 41.601 - Utility services forms.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Utility services forms. 41... CATEGORIES OF CONTRACTING ACQUISITION OF UTILITY SERVICES Forms 41.601 Utility services forms. (a) If acquiring utility services under other than an areawide contract, a purchase order, or an...

  18. 7 CFR 3560.202 - Establishing rents and utility allowances.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Establishing rents and utility allowances. 3560.202... Establishing rents and utility allowances. (a) General. Rents and utility allowances for rental units in Agency... Agency. (b) Agency approval. All rents and utility allowances set by borrowers are subject to...

  19. 24 CFR 891.440 - Adjustment of utility allowances.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Adjustment of utility allowances... Project Management § 891.440 Adjustment of utility allowances. This section shall apply to projects funded... submit an analysis of any utility allowances applicable. Such data as changes in utility rates and...

  20. 48 CFR 552.241-71 - Disputes (Utility Contracts).

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Disputes (Utility....241-71 Disputes (Utility Contracts). As prescribed in 541.501, insert clause 552.241-71, Disputes (Utility Contracts), in solicitations and contracts for utility services subject to the jurisdiction...