WorldWideScience

Sample records for nodulaere regeneratorische hyperplasie

  1. Focal nodular hyperplasia and hepatocellular adenoma; Fokale nodulaere Hyperplasie und hepatozellulaeres Adenom

    Energy Technology Data Exchange (ETDEWEB)

    Bastati-Huber, N.; Poetter-Lang, S.; Ba-Ssalamah, A. [Medizinische Universitaet Wien, Universitaetsklinik fuer Radiologie und Nuklearmedizin, Abteilung fuer Allgemeine Radiologie und Kinderradiologie, Department of Biomedical Imaging and Image-guided Therapy, Wien (Austria)

    2015-01-01

    Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) are liver lesions of hepatocellular origin. The FNH is a commonly occurring hepatic lesion whereas HCA is very rare. Non-invasive differentiation between HCA subtypes and atypical FNH may pose a diagnostic challenge as both entities predominantly occur in middle-aged female patients. The conventional imaging modalities include ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI). Distinguishing FNH from HCA is of great importance clinically as FNH is considered to be a benign lesion and needs no further management. In contrast HCA is considered to be a borderline tumor due to the risk of hemorrhage, growth and even malignant transformation and requires individualized management. The abovementioned radiological procedures usually enable an accurate and certain diagnosis of a typical FNH to be achieved. In cases of atypical FNH, particularly in patients with a clinical history of malignancy, these imaging modalities are insufficient to establish a clear diagnosis. In this scenario, the use of modern hepatobiliary contrast-enhanced MRI will enable a differentiation between FNH and metastasis with a high sensitivity and specificity. Furthermore, it allows a differentiation of FNH from 90 % of adenoma subtypes. This article describes the histopathological and radiological features of these lesions and explains the advantages and limitations of various imaging modalities used for the diagnosis and differentiation of these entities. The new classification of HCAs according to phenotype and genotype and their imaging features, as well as different enhancement patterns, are described. The correlation between HCA subtypes and their individual management are also discussed. (orig.) [German] Die fokale nodulaere Hyperplasie (FNH) und das hepatozellulaere Adenom (HCA) sind Leberlaesionen hepatozellulaeren Ursprungs. Die FNH ist eine sehr haeufige, das HCA eine sehr seltene Leberlaesion

  2. HRCT of the lung. Nodular pattern: anatomy and differential diagnosis; HRCT der Lunge. Nodulaere Muster: Anatomie und Differenzialdiagnose

    Energy Technology Data Exchange (ETDEWEB)

    Biederer, J. [Universitaetsklinikum Schleswig-Holstein, Campus Kiel, Klinik fuer Diagnostische Radiologie, Kiel (Germany); Reuter, M. [Vivantes Klinikum Berlin-Neukoelln, Institut fuer Radiologie und Interventionelle Therapie, Berlin (Germany)

    2010-06-15

    Since the spectrum of differential diagnoses is wide, the interpretation of a nodular pattern in lung lesions detected on CT is a frequent problem. Number, size, localization, and morphology (shape, density, margins) contribute to evaluating the most probable differential diagnosis. ''Classical'' high resolution CT or high resolution image reconstructions from multiple row detector CT helical acquisitions achieve a detail resolution that makes it possible to distinguish findings by their typical predominance in certain anatomical compartments of the lung. The position of bronchial, vascular and lymphatic structures can be determined down to the secondary pulmonary lobule, the smallest subunit of the lung to be separated by septa of connective tissue. Based on this, a centrilobular predominance of nodules, i.e. with a tree-in-bud pattern, is a frequent sign of bronchiolitis. Perilymphatic predominance in the periphery of the lobules is associated with sarcoidosis or lymphangitic spread of cancer. Random distribution of nodules is interpreted as a sign of hematogenic spread of disease. Hence the subtle interpretation of specific findings on HRCT can contribute substantially to clinical decision making, although these signs may not always replace biopsy and histologic workup. (orig.) [German] Der Nachweis kleiner nodulaerer Lungenlaesionen mittels CT ist aufgrund der Vielzahl der moeglichen Differenzialdiagnosen ein haeufiges klinisches Problem. Neben Anzahl und Groessenverteilung der Knoten tragen Lokalisation und morphologische Kriterien (Form, Dichte, Begrenzung) zur Abschaetzung der wahrscheinlichsten Differenzialdiagnose bei. Die ''klassische'' HRCT-Technik oder hoch aufloesende Rekonstruktionen aus Spiraldatensaetzen erreichen eine Detailaufloesung, die die Zuordnung der Befunde zu anatomischen Kompartimenten der Lunge erlaubt. Bis auf die Ebene des sekundaeren Lobulus, der kleinsten, von bindegewebigen Strukturen

  3. Recurrences in chronic tonsillitis substained by tonsillar biofilm-producing bacteria in children. Relationship with the grade of tonsillar hyperplasy.

    Science.gov (United States)

    Torretta, Sara; Drago, Lorenzo; Marchisio, Paola; Cappadona, Maurizio; Rinaldi, Vittorio; Nazzari, Erica; Pignataro, Lorenzo

    2013-02-01

    It has been suggested that bacterial biofilms are involved in chronic tonsillar disease, but there is a lack of strong evidence concerning their etiopathogenic role in childhood chronic tonsillar infections. The aim of this study was to assess the presence of biofilm-producing bacteria (BPB) in tonsillar bioptic specimens taken from children with recurrent exacerbations of chronic hyperplastic tonsillitis, and to evaluate the possible relationship between them and the patients' demographic and clinical characteristics. 22 children (68.2% males; median age 6.5 years, range 3-13) with recurrent exacerbations of chronic hyperplastic tonsillitis were included. The presence of tonsillar BPB was assessed by means of the spectrophotometric analysis of tonsillar bioptic specimens taken during tonsillectomy between episodes of tonsillar infection. BPB were found in 50.0% of the 44 tonsillar specimens, and Staphylococcus aureus was the most frequent pathogen (81.8%). There was a significant relationship (p=0.02) between the grade of tonsillar hyperplasy (GTH) and the presence of tonsillar BPB, with an increased relative risk (RR=4.27, standard error=2.57, pchildren with GTH scores of >2. The findings of this study: (1) confirm the presence of tonsillar BPB in children with recurrent exacerbations of chronic tonsillar infections; (2) suggest that GTH is an important indicator of the presence of tonsillar BPB; and (3) raise the question as to whether tonsillar biofilm is a causative factor or just a consequence of recurrent exacerbations of chronic hyperplastic tonsillitis. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  4. Simvastatin Therapy is not Associated with Improved Autogenous Internal Arteriovenous Fistula in Neointimal Hyperplasis on 5/6 Nephrectomy Rats Outcomes%辛伐他汀未能改善5/6肾切除大鼠自体动静脉内瘘血管内膜增生

    Institute of Scientific and Technical Information of China (English)

    郑尘非; 张周沧; 徐利鸳; 刘毅; 郑景晨

    2013-01-01

    Objective: To investigate the effectness of simvastatin on neointimal hyperplasis of autogenous internal arteriove-nous fistula in rats model with chronic renal failure by 5/6 nephrectomy. Methods: 36 rats were randomly divided into three groups: sham group, CRF control group and CRF statin group of 12 each . CRF models were made by 5/6 nephrectomy and then followed by end - to - end anastomosis of the right carotid artery and internal jugular vein. After the operation for 7 and 28 days, rats were sacrificed , and the blood sample was taken for renal funtion and lipids, also the vein near the anastomosis site were examined for histologi-cal changes after staining with HE, combined staining for elastic and collagen fibers, and immunohistochemical staining for alpha SMA and PCNA. Results:( 1 )Renal function and lipids: Blood creatinine and BUN levels were significantly increased in the CRF control group and CRF statin group than sham group( P 0. 05 ). (3 )Immunohistochemisty results showed that alpha SMA, PCNA were significantly increased in CRF control and CRF statin groups compared to sham group( P 0. 05 ). Conclusion: Simvastatin therapy is not associated with improved autogenous internal arteriovenous fistula in neointimal hyperplasis on 5/6 Nephrectomy rats outcomes.%目的:观察辛伐他汀对5/6肾切除大鼠自体移植静脉内膜增生的影响,探讨其防治透析内瘘内膜增生是否有潜在的价值.方法:36只大鼠随机分为3组:假手术组、CRF对照组和CRF他汀组各12只.各组在成模后分别于第7天、28天各处死6只,抽血行肾功能、血脂检测,并取其内瘘内膜组织行组织病理学检查.比较相同时间点各组肾功能,血脂及内膜增生程度.结果:(1)肾功能和血脂:与同一时点假手术组相比,CRF对照组、CRF他汀组造模后第7、28天后的肌酐和尿素氮均显著增高(P<0.05),各组血脂无显著差异.(2)新生内膜面积、厚度测定:术后第7天,已见各组内瘘血管

  5. Genderrol gedrag bij meisjes met congenitale adrenogenitale hyperplasie

    NARCIS (Netherlands)

    F.M.E. Slijper (Froukje)

    1983-01-01

    textabstractIn the literature (Ehrhardt et al. 1974) the difference in gender role behaviour between CAH girls and control girls is described as tomboy behaviour. By tomboy behaviour in girls with CAH is meant: - expression of physical energy in outdoor games and sports - preference for playing with

  6. Genderrol gedrag bij meisjes met congenitale adrenogenitale hyperplasie

    OpenAIRE

    Slijper, Froukje

    1983-01-01

    textabstractIn the literature (Ehrhardt et al. 1974) the difference in gender role behaviour between CAH girls and control girls is described as tomboy behaviour. By tomboy behaviour in girls with CAH is meant: - expression of physical energy in outdoor games and sports - preference for playing with boys' toys rather than with girl s and girls' toys little interest in marriage, pregnancy, motherhoed and caring for young children - a preferenee for casual clothes (particularly trousers) and a ...

  7. Inflammation et hyperplasie bénigne de la prostate : cause ou conséquence?

    NARCIS (Netherlands)

    Robert, G.Y.M.; Salagierski, M.; Schalken, J.A.; Taille, A. De La

    2010-01-01

    INTRODUCTION AND OBJECTIVES: Although benign prostatic hyperplasia (BPH) is the most frequent disease in elderly men, only a few predictive factors have been clearly identified. Recently, chronic prostatic inflammation has emerged as one of them. This review aims at describing the scientific proof o

  8. Inflammation et hyperplasie bénigne de la prostate : cause ou conséquence?

    NARCIS (Netherlands)

    Robert, G.Y.M.; Salagierski, M.; Schalken, J.A.; Taille, A. De La

    2010-01-01

    INTRODUCTION AND OBJECTIVES: Although benign prostatic hyperplasia (BPH) is the most frequent disease in elderly men, only a few predictive factors have been clearly identified. Recently, chronic prostatic inflammation has emerged as one of them. This review aims at describing the scientific proof o

  9. Imaging study of hepatic focal nodular hyperplasis%肝脏局灶性结节性增生的影像学研究

    Institute of Scientific and Technical Information of China (English)

    杨伟萍; 曾凡剑; 韦长元; 丁战铃

    2011-01-01

    Objective To explore the experience on the diagnosis and treatment of hepatic focal nodular hyperplasia (FNH).Methods Clinical data of 31 FNH patients, including the clinical manifestations,laboratory tests, imaging, diagnosis and treatment, were studied retrospectively.Results Twenty-five cases (80.6%) were young adults ( less than 40 years old).Most of the patients(74.2% ,23/31 ) had no obvious symptoms, and HBsAg positive was only in one case.All the patients had normal liver functions,while AFP ,CA19-9 and other tumor markers were within normal range.Twenty-seven patients had a single solitary focus and 4 had two lesions.Most of the lesions were located in hepatic segments Ⅳ, Ⅴ and Ⅷ.Lesion sizes ranged between 0.5 cm and 15.0 cm.The rate of diagnosis in this group was 3.2 % by color Doppler ultrasound, 32.1% (9/28) by CT, 20% (2/10) by MRI, and 0% (0/3) by hepatic artery angiography.Correct preoperative diagnosis was made in only 3 cases ( 9.7 % ).Thirteen cases ( 41.9 % )were misdiagnosed as liver cancer, 4 misdiagnosed as hepatic adenoma, 2 misdiagnosed as hepatic hemangioma and 9 cases had indefinite diagnosis.Twenty-nine cases underwent hepatic resection, and 2 cases were treated conservatively after the diagnosis was confirmed by the comprehensive utilization of biopsy and imaging examinations.Follow- up time was 8 months to 6.5 years, and all the operated patients suffered no relapse.Two patients, who were treated conservatively, were followed up for 18 months to 53 months,and they were all alive, without significant changes in lesion sizes.Conclusions Most cases of FNH have no clinical symptoms, and an effective method to improve the diagnostic accuracy of FNH is by the comprehensive analysis of the imaging examinations.The patients suspected of FNH may undergo percutaneous biopsy and those symptomless patients who have a definite diagnosis of FNH, may be treated by regular and close observation.%目的 探讨肝脏局灶性结节性增生的诊治经验.方法 回顾性分析31例FNH患者的临床表现、影像学检查、诊断及治疗方法 等临床资料.结果 全组31例中25例(80.6%)为40岁以下青壮年,23例(74.2%,23/31)无明显症状,HbsAg阳性1例,肝功能,AFP,CA19-9等肿瘤标记物均在正常范围内.单发肿瘤27例,4例为2个病灶.病灶多位于Ⅳ,Ⅴ,Ⅷ肝段.病灶大小0.5~15.0 cm.FNH术前诊断符合率分别为:彩超3.2%(1//31),CT 32.1%(9/28),MRI 20.0%(2/10),肝动脉造影0(0/3).术前诊断正确3例(9.7%),误诊为肝癌13例(41.9%),肝腺瘤4例(12.9%),肝血管瘤2例(6.5%),诊断不明9例(29.0%).手术切除29例,2例经皮穿刺活检及影像学检查等确诊后予保守治疗.随访时间8个月至6.5年,29例术后均无复发.未手术2例,随访时间18~53个月,均健在,肿块大小无明显变化.结论 FNH患者往往无临床症状,对影像学检查结果 进行综合分析,是提高FNH正确诊断率的有效方法 .怀疑FNH者,可经皮穿刺活检协助诊断,对于诊断明确、无症状的FNH,可定期观察,无需治疗.

  10. Therapeutic Effect for Treating Hyperplasis of Prostate Gland by Electric Acupuncture%电针治疗良性前列腺增生症疗效观察

    Institute of Scientific and Technical Information of China (English)

    张健; 刘拥军; 陈东; 李晓艳

    2012-01-01

    Objective: To compare the therapeutic effects of electric acupuncture therapy and routine acupuncture therapy on dysuria caused by hyperplasia of prostate gland after treatment. Methods: Randomized, controlled, single bland clinical method was adopted. 173 cases were divided into an electric acupuncture ( EA) group and a routine acupuncture( RA) group. Acupuncture was given at Shenshu( BL23 ) and Huiyang( BL35 ) in two groups, once daily, six sessions for one course, with a two - day interval between two courses. The treatment was given for two courses. Changes of I - PSS symptom cumulative score, urine flowing rate, residual u-rine in bladder before and after the treatment were evaluated. Results: There were significant differences between two groups in the improvement of I — PSS score, increase of urine flowing rate and reducation of residual urine in bladder (P<0.05). Conclusion:The electric acupuncture therapy has a significant curative effect for hyperplasia of prostate gland.%目的:评价电针疗法与常规针法对良性前列腺增生症(BPH)导致的排尿困难的作用.方法:采用随机、对照、单盲临床实验,将173例患者随机分为电针组(89例)和常规针刺组(84例).均取肾俞、会阳每天治疗1次,6次为1个疗程,疗程间间隔2天,共治疗2个疗程.对治疗前后前列腺症状(Ⅰ-PSS)积分、最大尿流量、残余尿量的变化进行评价.结果:在改善患者Ⅰ- PSS积分和最大尿流量、残余尿量变化等方面,两组均有效,且电针组优于常规针刺组(P<0.05).结论:电针治疗良性前列腺增生症疗效显著.

  11. 寰枢关节不对称、钩突增生与中青年颈性眩晕的相关性%Investigation of the relationship between atlanto-axial joint asymmetry, Luschka's joint hyperplasy and cervical vertigo in the middle age and youth

    Institute of Scientific and Technical Information of China (English)

    杨星; 乔俊霞; 付芳侠; 刘嵩

    2012-01-01

    Objective To investigate the relationship between atlanto-axial joint asymmetry, Luschka's joint hypcrplasy and cervical vertigo in the middle age and youth. Methods Two hundred and twenty-two patients with cervical vertigo in the middle age and youth were selected as the cervical vertigo group. Two hundred and three cases of the normal people were selected as the control group. All the subjects were taken mouth position and lateral X-ray photographs of cervical spine. Atlanto-axial joint asymmetry and Luschka's joint hypcrplasy were statistically evaluated by using correlation analysis. Results In the cervical vertigo group, 93. 24% (207/222) vertigo patients were atlanto-axial joint asymmetry. 23. 87% (53/222) patients were Luschka's joint hypcrplasy. In the control group, forty-eight cases were atlanto-axial joint asymmetry, accounting for 23. 65% of all unqualified. Sixty-five cases were Luschka's joint hypcrplasy, accounting for 32. 02% of all unqualified. Atlanto-axial joint asymmetry was negatively correlated with cervical vertigo in the middle age and youth (r=- 0.710, P0. 05). Conclusion Atlanto-axial joint asymmetry is negatively correlated with cervical vertigo in the middle age and youth. Atlanto-axial joint asymmetry is one of the main factors of cervical vertigo in the middle age and youth.%目的 探讨寰枢关节不对称、钩突增生与中青年颈性眩晕的相关性.方法 选取中青年颈性眩晕患者222例为眩晕组,无症状者203例为对照组.所有研究对象均摄取颈椎张口位及正侧位X线片,对其寰枢关节不对称及钩突增生情况做相关性分析.结果 颈性眩晕组中207例寰枢关节不对称,异常率93.24%;53例钩突增生,增生率23.87%.对照组中48例寰枢关节不对称,异常率23.65%;65例钩突增生,增生率32.02%.寰枢关节不对称与中青年颈性眩晕呈显著的负相关(r=-0.710,P<0.01);钩突增生与中青年颈性眩晕无相关性(r=0.091,P>0.05).结论 寰枢关节不对称与中青年颈性眩晕密切相关,是引起中青年颈性眩晕的重要因素之一.

  12. Pharmacology of airway smooth muscle proliferation

    NARCIS (Netherlands)

    Gosens, Reinoud; Roscioni, Sara S.; Dekkers, Bart G. J.; Pera, Tonio; Schmidt, Martina; Schaafsma, Dedmer; Zaagsma, Johan; Meurs, Herman

    2008-01-01

    Airway smooth muscle thickening is a pathological feature that contributes significantly to airflow limitation and airway hyperresponsiveness in asthma. Ongoing research efforts aimed at identifying the mechanisms responsible for the increased airway smooth muscle mass have indicated that hyperplasi

  13. The TRAPIST Study. A multicentre randomized placebo controlled clinical trial of trapidil for prevention of restenosis after coronary stenting, measured by 3-D intravascular ultrasound.

    NARCIS (Netherlands)

    P.W.J.C. Serruys (Patrick); D.P. Foley (David); M. Pieper (Michael); J.A. Kleijne; P.J. de Feyter (Pim)

    2001-01-01

    textabstractBACKGROUND: Studies have reported benefit of oral therapy with the phosphodiesterase inhibitor, trapidil, in reducing restenosis after coronary angioplasty. Coronary stenting is associated with improved late outcome compared with balloon angioplasty, but significant neointimal hyperplasi

  14. Management von Endometriumhyperplasien. Gemeinsame Stellungnahme der DGGEF und des BVF e. V.

    Directory of Open Access Journals (Sweden)

    Römer T

    2014-01-01

    Full Text Available Blutungsstörungen, insbesondere bei Östrogendominanz im reproduktiven Alter, z. B. bei PCO-Syndrom (durch Anovulation fehlende Gestagenwirkung und starker Adipositas bzw. in höherem Lebensalter, können durch eine Endometriumhyperplasie bzw. durch ein Endometriumkarzinom bedingt sein. Das Endometriumkarzinom ist ein östrogenabhängiger Tumor, der überwiegend im höheren Lebensalter auftritt. Endometriumkarzinome entstehen in der Regel über Vorstufen (z. B. komplexe und atypische Hyperplasie bei überwiegender oder reiner Östrogen-Exposition, z. B. durch Östrogen-Monotherapie bei Frauen in der Postmenopause mit erhaltenem Uterus. Risikofaktoren: Histologische Subtypen der Endometriumhyperplasie und Entartungsrisiko nach traditioneller Klassifikation (1994 und 2003/WHO-Klassifikation (1994/2003: glandulär-zystische Hyperplasie/einfache Hyperplasie: 1–3 %, adenomatöse Hyperplasie (Grad 1 und Grad 2/komplexe Hyperplasie: 3 % (Grad 1, 8 % (Grad 2, adenomatöse Hyperplasie (Grad 3/atypische Hyperplasie: 30 % Diagnostik: Vaginalsonographie, Hysteroskopie und fraktionierte Curettage mit histologischer Begutachtung des Abradats. Therapieoptionen: Bei abgeschlossener Familienplanung, einem höheren Lebensalter und evtl. weiteren Zusatzindikationen ist die Hysterektomie die Therapie der Wahl. Bei Wunsch nach Erhalt des Uterus kann z. B. eine hoch-dosierte Gestagentherapie über 3–6 Monate erfolgen. Anschließend ist eine Recurettage zur Diagnostik erforderlich. Alternativ kann bei Frauen mit späterem Kinderwunsch in Abhängigkeit von der Histologie die vorübergehende Einlage eines LNG-IUS sinnvoll sein (off label. Gestagentherapie: – Behandlung der Endometriumhyperplasie: Bei einfacher aber auch komplexer Endometriumhyperplasie wurden Erfolge durch Einlage eines LNG-IUS beschrieben (off-label. – Behandlung von Frühformen des Endometriumkarzinoms bei Wunsch nach Uteruserhalt: Es gibt Einzelfallberichte über die erfolgreiche Therapie

  15. NMR imaging of the liver. Diagnostics, differential diagnostics, therapeutic approaches; MRT der Leber. Diagnostik, Differenzialdiagnostik, Therapieansaetze

    Energy Technology Data Exchange (ETDEWEB)

    Fischbach, Frank; Fischbach, Katharina [Universitaetsklinikum Magdeburg A.oe.R. (Germany). Klinik fuer Radiologie und Nuklearmedizin

    2017-03-01

    The book on NMR imaging of the liver covers the following issues: Fundamentals of NMR imaging, T1-weighted imaging; T2-weighted imaging, diffusion-weighted imaging, cavernous hemangioma, focal nodular hyperplasy; hepatocellular adenoma, hepatocellulas carcinoma, cholangiocellular carcinoma, hepatic metastases.

  16. COMMENTS ON CLINICAL APPLICATION OF LOCAL MULTI-NEEDLE PUNCTURING

    Institute of Scientific and Technical Information of China (English)

    MENG Xiangwen

    2002-01-01

    In the present paper, combining a few of typical cases, the author introduces his clinical experiences about the application of multiple acupuncture needles inserted into a certain local region for treatment of facial spasm,Iumbago, hyperplasis of the mammay glands and herpes zoster and gives some brief comments.

  17. Perifert ameloblastom

    DEFF Research Database (Denmark)

    Reibel, Jesper; Jensen, Jesper Bak

    2016-01-01

    -/præmolarområde. Tilstanden opdagedes hos egen tandlæge og blev behandlet som parodontal sygdom. På grund af manglende behandlingseffekt henvistes patienten til Afdeling for Kæbekirurgi og Oral Patologi på Tandlægeskolen i Aarhus. Klinisk mistænktes for pyogent granulom eller anden irritationsbetinget hyperplasi. Der blev...

  18. HRCT patterns of the most important interstitial lung diseases; HRCT-Muster der wichtigsten interstitiellen Lungenerkrankungen

    Energy Technology Data Exchange (ETDEWEB)

    Schaefer-Prokop, C. [Meander Medisch Centrum, Abt. Radiologie, Amersfoort (Netherlands); Radboud Universitaet, Abt. Radiologie und Nuklearmedizin, Nijmegen (Netherlands)

    2014-12-15

    Interstitial lung diseases are a mixed group of diffuse parenchymal lung diseases which can have an acute or chronic course. Idiopathic diseases and diseases with an underlying cause (e.g. collagen vascular diseases) share the same patterns. Thin section computed tomography (CT) plays a central role in the diagnostic work-up. The article describes the most important interstitial lung diseases following a four pattern approach with a predominant nodular or reticular pattern or a pattern with increased or decreased lung density. (orig.) [German] Interstitielle Lungenerkrankungen stellen eine gemischte Gruppe diffuser Lungenparenchymerkrankungen dar, die einen akuten oder chronischen Verlauf haben koennen. Idiopathische Erkrankungen und Erkrankungen mit definierter Ursache (z. B. kollagenvaskulaere Erkrankungen) weisen ein gemeinsames Muster auf. Die Duennschichtcomputertomographie spielt eine zentrale Rolle in der diagnostischen Abklaerung. In dem vorliegenden Beitrag werden die wichtigsten interstitiellen Lungenerkrankungen beschrieben. Dabei gibt es 4 Grundmuster: ueberwiegend nodulaere Verdichtungen, vorwiegend retikulaere Verdichtungen, erhoehte oder erniedrigte Lungenparenchymdichte. (orig.)

  19. COEXISTENCE OF OSTEOARTHRITIS AND OSTEOPOROSIS IN FEMORAL HEAD: A SCANNING ELECTRON MICROSCOPIC STUDY

    Institute of Scientific and Technical Information of China (English)

    柴本甫; 汤雪明; 李慧

    2000-01-01

    ffeSUtn6 Objectif Detenniner ie cusistence d' ostdoarthrite et d' ostdope dans la tste du femur. liChen 12 femmes (age moron 56 ans )atteintes d' ortdoorthrite de la hanche, on a Prdlevd la tste du femur durant la substitutiontotale de l' articulation de leur hanche. APrds das traitements, Ies tstes du femur furent studioes sons ie microscope dlectroniqued belang (soon ). ~flats to lesions ostdcorthritiques de differents degrds (azractdrithe per ba digs~nce du cartilage articulaire et d' hyperplasie des tis...

  20. Usefulness of MRI in diagnosis of hepatocellular carcinoma (HCC)

    Energy Technology Data Exchange (ETDEWEB)

    Usuki, Noriaki; Kawabe, Jouji; Nishikawa, Minori; Fukuda, Haruyuki; Saiwai, Shigeo; Nakajima, Hideyuki; Miyamoto, Takeshi; Kudoh, Masatoshi (Kobe General City Hospital (Japan))

    1992-06-01

    Sixty-six cases of histologically proven hepatocellular carcinomas (HCC) were studied by MRI. Detectability was better by MRI than by CT, especially in the tumor under 2 cm in diameter. The capsule was detected in all cases of HCC over 3 cm in diameter. The capsule was able to be diagnosed only by dynamic MRI study in some cases. High intensity on the T1-weighted image and iso or low intensity on the T2-weighted image suggested that the nodule was adenomatous hyperplasi (AH) or well differentiated HCC. MRI is concluded to be an essential modality in the diagnosis of HCC. (author).

  1. Morphometric analysis of the parotid gland affected by alcoholic sialosis.

    Science.gov (United States)

    Bohl, Luciana; Merlo, Carolina; Carda, Carmen; Gómez de Ferraris, María Elsa; Carranza, Miriam

    2008-09-01

    In alcoholic parotid sialosis, the gland is frequently enlarged due to ductal and/or acinar hypertrophy, ductal hyperplasy and stromal fat infiltration. The aim of this study was to determine acinar and ductal dimensions, the number of striated ducts and the proportion of fat tissue in patients with and without alcoholic parotid sialosis. Twelve parotid biopsy samples from patients with hepatic alcoholic cirrhosis and those from seven controls were used. A morphometrical study with a digital image analyser attached to an optical microscope was carried out. Direct and indirect indicators from acinar and ductal dimensions were recorded. The number of striated ducts and the proportion of fat tissue in stroma were determined. Fifteen records for each variable were taken. Mean values were compared using the Mann-Whitney U-test (P hyperplasy in alcoholic patients. The main cause of parotid enlargement could not be stromal fat infiltration. The data could be used for differential diagnoses of sialosis.

  2. [Potentialities of computed tomography and ultrasound in diagnosis of hormonally active adrenal diseases: results of comparison CT and US with operative adn histological data].

    Science.gov (United States)

    Denisova, L B; Vorontsova, S V; Emel'ianova, L N

    2000-01-01

    The data given in the paper suggest that X-ray computed tomography (CT) is highly effective in detecting all types of hormonally active adrenal abnormalities. CT used in hormonally active adrenal diseases yielded data on major quantitative and qualitative (primarily densitometric) criteria that could be used in assessing the images of the adrenal area in these patients. Ultrasound study (USS) made at the first stage of topical diagnostic searches was of informative value in detecting adrenal tumor lesions, the technique being highly sensitive in the diagnosis of adrenal pheochromocytomas and adenocarcinomas, but less informative in the detection of hormonally active adrenocortical adenomas (aldesterone-producing ones in particular) than CT. The diagnosis of various adrenocortical hyperplasies and the differentiation of hyperplastic and tumor forms of hypercorticoidism are a prerogative of CT that substantially supplements USS findings in such cases.

  3. Computed tomography of the abnormal thymus

    Energy Technology Data Exchange (ETDEWEB)

    Baron, R.L.; Lee, J.K.T.; Sagel, S.S.; Levitt, R.G.

    1982-01-01

    Computed tomography (CT) should be the imaging method of choice following plain chest radiographs when a suspected thymic abnormality requires further evaluation. Based upon a six-year experience, including the evaluation of 25 patients with thymic pathology, CT was found useful in suggesting or excluding a diagnosis of thymoma and in distinguishing thymic hyperplasis from thymoma in patients with myasthenia gravis. The thickness of the thymic lobes determined by CT was found to be a more accurate indicator of infiltrative disease (thymic hyperplasia and lymphoma) than the width. CT was helpful in differentiating benign thymic cysts from solid tumors, and in defining the extent of a thymic neoplasms. On occasion, CT may suggest the specific histologic nature of a thymic lesion.

  4. E2FBP1/hDril1 modulates cell growth through downregulation of promyelocytic leukemia bodies.

    Science.gov (United States)

    Fukuyo, Y; Mogi, K; Tsunematsu, Y; Nakajima, T

    2004-07-01

    Promyelocytic leukemia nuclear bodies (PML-NBs) comprise multiple regulatory factors and play crucial roles in the maintenance of cellular integrity, while unregulated activation of PML-NBs induces death and premature senescence. Hence, the function of PML-NBs must be directed properly; however, the mechanism that regulates PML-NBs remains unclear. In this paper, we show that PML-NBs are disintegrated by an AT-rich interaction domain family protein E2FBP1/hDril1 through specific desumoylation of promyelocytic leukemia protein (PML) in vivo and in vitro. RNA interference-mediated downregulation of E2FBP1/hDril1 results in hyperplasis of PML-NBs and consequent commitment to PML-dependent premature senescence. Thus, the function of E2FBP1/hDril1 is required for maintenance of survival potential of the cells. Our data suggest a novel mechanism to govern cellular integrity through the modulation of nuclear depots.

  5. Biocompatibility of coronary stent materials: effect of electrochemical polishing

    Energy Technology Data Exchange (ETDEWEB)

    Scheerder, I. de [University Hospital Leuven (Belgium). Dept. of Cardiology; Sohier, J.; Froyen, L.; Humbeeck, J. van [Louvain Univ. (Belgium). Dept. of Metallurgy and Materials Engineering; Verbeken, E. [University Hospital Leuven (Belgium). Dept. of Pathology

    2001-02-01

    are under development in order to decrease the neointimal hyperplastic response. (orig.) [German] Perkutane Transluminale Koronare Revaskularisierung (PTKR) ist heutzutage eine weit akzeptierte Behandlungsmodalitaet koronararterieller Krankheit. Heutige randomisierte Vielzentrenstudien vergleichen PTKR und mehr intervenierende Koronaraterie-Ueberbrueckungs-Chirurgie (KABC) miteinander. Sie konnten keine signifikanten Unterschiede zeigen. In den letzten 10 Jahren wurden Fortschritte gemacht um PTKR weiter zu optimieren. Die logische Weise um atherosklerotische Koronarverengungen zu behandeln, ist die Entfernung des atherosklerotischen Materials mit speziellen Hilfsmitteln. Aber verschiedene Studien konnten kein signifikantes heilsames Resultat zeigen nach Gebrauch dieser Hilfsmittel im Vergleich mit der gewohnten Ballonangioplastie. Eine andere Methode war die Einpflanzung einer Koronarprothese (Stent), die die kranke Koronaraterie nach PTCA stuetzen sollte. Diese Arbeitsweise resultierte in einem verringerten Restenosegrad bei Nachuntersuchungen. Das heilsame Ergebnis des Stents war jedoch nicht verbunden mit der Sperrung der neointimalen zellularen Vervielfaeltigung nach vaskulaerer Verletzung, sondern war einfach das mechanische Resultat der Ueberdehnung des behandelten Blutgefaesses. Das wichtigste klinische Problem nach dem Stenten bleibt jedoch die Hyperplasie im Stent, resultierend in einer signifikanten Verengung des Stents bei 13 bis 30% der Patienten. Weitere Anstrengungen um die klinischen Ergebnisse koronaren Stentes zu verbessern sollten sich auf die Reduktion der neointimalen Hyperplasie konzentrieren. Die neointimale Hyperplasie nach Einpflanzung eines Stents resultiert aus (1) einer heilenden Antwort auf die Verletzungen verursacht durch die Einpflanzung eines Stents und (2) eine Fremdkoerper-Antwort gegen den Stent selbst. Die Faktoren, die die neointimale Hyperplasie wahrscheinlich beeinflussen sind Faktoren, die in Verbindung stehen mit der Genetik

  6. Reprogrammation métabolique induite dans les tissus hyperplasiques formés chez le tabac infecté par Rhodococcus fascians: aspects fondamentaux et applications

    OpenAIRE

    Nacoulma, Aminata

    2013-01-01

    Les pathosystèmes, plante-bactérie, aboutissent souvent au niveau de la plante à de profondes reprogrammations tant au niveau de la morphogenèse que du métabolome. Dans le cas de l’interaction plante-Rhodococcus fascians, une bactérie phytopathogène, il se développe au niveau du site d’infection, une structure morphologique particulière nommée « galle feuillée ». Au sein de cette hyperplasie, les altérations métaboliques induites concernent non seulement les produits du métabolisme primaire m...

  7. 乳腺增生病的彩色多普勒超声诊断与病理对照分析%Galactophore hyperplasia:a comparative analysis between color doppler flow imaging and pathology

    Institute of Scientific and Technical Information of China (English)

    韩曼彤; 陈念德; 冼兆新

    2001-01-01

    Objective:To evaluate the value of two-dimensional sonogram andcolor Doppler Flow Imaging(CDFI) in diagnosing galactophore hyperplasia(PH).Methods:A retrospective analysis of the two dimensional sonogram and CDFI features was conducted to 40 cases of galactophore hyperplasis confirmed by patholgy,and the results were compared to the findings of pathology.Results:The correct rate of ultrasound diagnosis was 80%.The sonograms of PH could be divided into three types in accordance with pathological morphology which are simple hyperplasis, cystic hyperplasia and adenoidal hyperplasia.In 10% cases of PH,color signal could be detected.Conclusion:Two-dimensional sonogram,together with CDFI,has shown some clinical significance to the diagnosis of PH.%目的:探讨二维声像图及CDFI对乳腺增生病的诊断价值。方法:对40例经手术病理或病理活检证实为乳腺增生病的二维声像图及CDFI表现进行了分析,并与病理分型作对照。结果:本文的超声诊断正确率为80%。按其病理分为单纯性增生,囊性增生,腺型增生三种。此病血流信号检出率为10%(4/40)。结论:二维声像图加CDFI诊断本病符合率高,是有一定的临床价值。

  8. Malignant schwannoma of the abdomen; Malignes Schwannom des Abdomens

    Energy Technology Data Exchange (ETDEWEB)

    Kraemer, S.C. [Abt. fuer Diagnostische Radiologie, Universitaetsklinikum Ulm (Germany); Kolokythas, O. [Abt. fuer Pathologie, Universitaetsklinikum Ulm (Germany); Aschoff, A.J. [Abt. fuer Diagnostische Radiologie, Universitaetsklinikum Ulm (Germany); Merkle, E. [Abt. fuer Diagnostische Radiologie, Universitaetsklinikum Ulm (Germany)

    1996-05-01

    A 63 year-old female patient presented herself because of abdominal distension, without being able to report specific complaints. Clinical examination found a well palpable, elastic and engorged abdominal tumour approximately of the size of a football. Conventional imaging of the small intestine according to Sellink with subsequent delayed film revealed in the first instance a displacement of intestinal loops and of the colon frame, with no signs of an onstruction. A similar diagnosis resulted from intraarterial angiography of the abdominal vessels, showing a displacement of the truncus coeliacus, and the A. mesenterica superior. There were no signs of vascular occlusions or pathologic tumour vessels. Surgery revealed a tumour of about 10 kg, with pathologic vascular connection and a broad area of contact to neighbouring intestinal loops. Control CT performed one year after surgery revealed newly developed, multiple, nodular formations, their structure and contrast signs being similar to those of the primary tumour. (orig./VHE) [Deutsch] Eine 63jaehrige Patientin stellte sich mit einer Zunahme des Bauchumfanges vor. Ausgepraegte Beschwerden waren nicht zu erfragen. Klinisch fiel ein gut palpabler, prall elastischer, etwa fussballgrosser Abdominaltumor auf. Die konventionelle Duenndarmdarstellung nach Sellink mit nachfolgenden Spaetaufnahmen zeigte in erster Linie eine Verlagerung der Darmschlingen und des Kolonrahmens ohne Nachweis einer Obstruktion. Einen aehnlichen Befund ergab die intraarterielle Angiographie der Bauchgefaesse mit einer Verlagerung des Truncus coeliacus und der A. mesenterica superior. Gefaessverschluesse oder pathologische Tumorgefaesse kamen jedoch nicht zur Darstellung. Intraoperativ wurde ein ca. 10 kg schwerer Tumor mit pathologischer Gefaessverbindung und breitem Kontakt zu benachbarten Darmschlingen gefunden. In der ein Jahr nach der Operation durchgefuehrten Kontrollcomputertomographie fanden sich erneut multiple nodulaere Formationen

  9. CORRELATIONS BETWEEN INTER-IMPLANT DISTANCE AND CLINICAL ASPECTS IN TWO IMPLANT MANDIBULAR OVERDENTURES

    Directory of Open Access Journals (Sweden)

    Mihaela Marin

    2011-09-01

    Full Text Available The aim of this study is to assess the influence of different interimplant distances on prosthetic complications in two implant mandibular overdenture treatments, as well as the possible correlations between such complications and some anatomic and functional individual aspect of the patients. Materials and method. An observational clinical study was conducted – between October 2008 – March 2010 - in the Clinics of Dental Prosthetics of the “Carol Davila” UMF of Bucuresti – on 32 completely edentulous patients, treated with 2 implant mandibular overdentures. The patients (24 women and 8 men, with ages between 49 and 83 years were divided into 2 groups, according to the position of the implants, inserted at the level of the lateral incisor (group 1 or in posterior position versus the canine (group 2. The prosthetic aspects, the peri-implant tissues and the anchoring systems were evaluated after 6 months and, respectively, 1 year of treatment, all prosthetic or biological complications, as well as the number of visits necessary for solving them being recorded. Results. As to the general characteristics of the group of patients, the observation was made that the average age of patients was of 63.8 years, most of them demonstrated a severe resorbtion of the crest, oval in shape in the mandibular frontal area, belonging mostly to the IInd hypo or hyper-divergent skeletal class, proportionally with and without a tendency towards propulsion. For both groups of patients, a total number of 114 prosthetic complications were registered after one year, the most frequent ones being occlusal problems (23.68%, the presence of decubitus lesions (21.05% and deactivation of matrices, accompanied by reduced retention (19.29%. Lower ratios were recorded for: the necessity of prosthesis relining (14%, loss of matrices (12.28%, fracturing of the prosthesis (8.77%, presence of peri-implant gingival hyperplasies (7% and loosening of the patrix screw (5

  10. 围绝经期子宫异常出血子宫内膜病理变化分析%Pathology of the endometrium in perimenopausal women with abnormal uterine bleeding

    Institute of Scientific and Technical Information of China (English)

    雷亚平; 胡雪涛

    2015-01-01

    Objective: To investigate the pathologic features of endometrium in perimenopausal women with abnormal uterine bleeding. Methods: The pathologic data of endometrium in 152 perimenopausal women with abnormal uterine bleeding were retrospectively analyzed. Results:Among 152 cases,the hyperplasis endometria in 74 cases(48. 68% ),proliferated phase of endometria in 48 cases(31. 58% ),secretory endometria in 18 cases(11. 84% ),hormone therapy endometria in 2 cases(1. 32% ),endometrial polyps in 7 cases( 4. 61% ),local endometrial cancer in 1 case(0. 66% ) and incomplete abortion in 2 cases(1. 32% ) were identified. Conclusions:Hyperplasis is the most common cause of the abnormal uterine bleeding in perimenopausal women, thereby the pathological diagnosis of endometrium should be noted.%目的::探讨围绝经期子宫异常出血患者的子宫内膜病理变化。方法:回顾性分析152例子宫异常出血患者诊刮子宫内膜的组织病理学资料。结果:152例子宫内膜中,增生性改变74例(48.68%),子宫内膜增殖期48例(31.58%),子宫内膜分泌期18例(11.84%),激素治疗后反应 2例(1.32%),子宫内膜息肉7例(4.61%),局灶癌变1例(0.66%),不全流产 2例(1.32%)。结论:子宫内膜增生性改变是围绝经期子宫异常出血最常见的原因之一,故应重视围绝经期子宫异常出血诊刮子宫内膜的病理诊断。

  11. Effect of radiosynovectomy in patients with inflammatory joint disorders not caused by rheumatoid arthritis; Wirksamkeit der Radiosynoviorthese bei degenerativ-entzuendlichen und chronisch-entzuendlichen Gelenkerkrankungen

    Energy Technology Data Exchange (ETDEWEB)

    Kroeger, S.; Klutmann, S.; Bohuslavizki, K.H.; Clausen, M. [Universitaetskrankenhaus Eppendorf, Hamburg (Germany). Abt. fuer Nuklearmedizin; Sawula, J.A.; Brenner, W.; Henze, E. [Kiel Univ. (Germany). Klinik fuer Nuklearmedizin

    1999-07-01

    Gelenke) mit peripherem Gelenkbefall bei Morbus Bechterew, reaktiver Arthritis, undifferenzierter Kollagenose mit Gelenkbeteiligung, Psoriasis-assoziierter Arthritis, pigmentierter villo-nodulaerer Synovialitis und chronisch-entzuendliche Reizzustaende nach vorangegangener Operation. Die Veraenderung der Beschwerdesymptomatik wurde anhand eines standardisierten Fragebogens entsprechend den ARA-Kriterien subjektiv erfasst und mit T/B-Quotienten in der Blutpoolphase der Skelettszintigraphie vor und nach der RSO quantifiziert. Ergebnisse: In der ersten Gruppe berichteten die Patienten ueber eine deutliche Besserung der Beschwerdesymptomatik in 40% der Faelle. In 51% fand sich eine Beschwerdekonstanz, in 9% eine Verschlechterung des Beschwerdebildes. Analoge Verhaeltnisse fanden sich in der zweiten Patientengruppe. Die Mehrzahl der als unveraendert beschriebenen Gelenke waren kleine Fingergelenke. Hingegen zeigten Hand- und Kniegelenke bessere Ergebnisse. Eine Uebereinstimmung zwischen szintigraphischem Befund und subjektiver Einschaetzung fand sich in der ersten Gruppe bei 38% und in der zweiten Gruppe bei 67%. Schlussfolgerung: Die Radiosynoviorthese stellt auch bei der aktivierten Arthrose und den nicht durch eine rheumatoide Arthritis verursachten Synovialitiden eine nebenwirkungsarme, gut nutzbare lokal anwendbare Therapieoption dar. (orig.)

  12. Classical patterns of interstitial lung diseases; Klassische Muster der interstitiellen Lungenerkrankungen

    Energy Technology Data Exchange (ETDEWEB)

    Mueller-Mang, C. [Institut fuer CT und MRT, Gaenserndorf (Austria); Medizinische Universitaet Wien, Universitaetsklinik fuer Radiologie und Nuklearmedizin, Wien (Austria)

    2014-12-15

    High resolution computed tomography (HRCT) is the most important non-invasive tool in the diagnostics and follow-up of patients with interstitial lung disease (ILD). A systematic review of the HRCT patterns of ILD was carried out and the most relevant differential diagnoses are discussed in order to provide a road map for the general radiologist to successfully navigate the complex field of ILD. Using HRCT four basic patterns of ILD can be identified: linear and reticular patterns, the nodular pattern, the high attenuation and low attenuation patterns. These patterns can be further differentiated according to their localization within the secondary pulmonary lobule (SPL), e.g. centrilobular or perilymphatic and their distribution within the lungs (e.g. upper or lower lobe predominance). Relevant clinical data, such as smoking history and course of the disease provide useful additional information in the diagnosis of ILD. On the basis of the pattern and anatomical distribution on HRCT, an accurate diagnosis can be achieved in some cases of ILD; however, due to morphological and clinical overlap the final diagnosis of many ILDs requires close cooperation between clinicians, radiologists and pathologists. (orig.) [German] Die hochaufloesende CT (High-resolution[HR]-CT) ist das wichtigste nichtinvasive Verfahren zur Identifikation und Verlaufsbeurteilung von Patienten mit interstitiellen Lungenerkrankungen (''interstitial lung diseases'', ILD). Systematische Darstellung der HRCT-Muster interstitieller Lungenerkrankungen und Diskussion der relevanten Differenzialdiagnosen, um dem Radiologen eine erfolgreiche Analyse der komplexen CT-Morphologie der ILD zu ermoeglichen. Mit der HRCT koennen 4 Grundmuster interstitieller Grunderkrankungen identifiziert werden: das retikulaere und lineare Muster, das nodulaere Muster, das Muster mit erhoehter Lungendichte und das Muster mit verminderter Lungendichte. Diese Muster koennen anhand ihrer Lage im sekundaeren

  13. Anticholinergika bei überaktiver Blase und benignem Prostatasyndrom

    Directory of Open Access Journals (Sweden)

    Gabuev A

    2007-01-01

    Full Text Available Das klinische Bild des benignen Prostatasyndroms (BPS ist vielfältig. Standardmäßig werden die Patienten mit benigner prostatischer Obstruktion operativ behandelt. Ein wesentlicher Anteil der betroffenen Männer leidet vorwiegend unter Drangsymptomen wie Pollakisurie und gehäuftem imperativen Harndrang mit oder ohne Harninkontinenz. Nach dem Versagen der primären konservativen Behandlung mit selektiven Alpha-1- Adrenoblockern und/oder 5-alpha-Reduktasehemmern in dieser Patientengruppe (Non-Responder wird häufig die Indikation zu weniger akzeptablen invasiven Therapieoptionen gestellt. Die Ergebnisse von internationalen multizentrischen Studien zur Wirkung von Anticholinergika bei Patienten mit dem Syndrom „überaktive Blase“ zeigten deren Effizienz und günstiges Nebenwirkungsprofil. Dies führte zur kritischen Betrachtung des Problems der Anwendung von Anticholinergika bei benigner Hyperplasie der Prostata als „klassische“ Kontraindikation und zu einer breiteren Indikationsstellung zur konservativen Therapie bei Non-Respondern. Die vorliegende Analyse der aktuellen Publikationen zur Anwendung von Anticholinergika zeigt, daß ein selektioniertes Patientenkollektiv mit irritativen Beschwerden bei BPS von dieser Therapie profitieren kann. Eine Tendenz zur Entwicklung des akuten Harnverhaltes konnte nicht eindeutig nachgewiesen werden. Eine kontrollierte Anwendung von Anticholinergika in Kombination mit selektiven Alpha-1-Blockern scheint möglich zu sein. Weitere Studien auf diesem Gebiet müssen noch nicht geklärte Fragen beantworten und die Wirkung von neuen anticholinergen Substanzen wie M3-selektiven Antimuskarinika oder Fesoterodin prüfen.

  14. Parotid sialosis: morphometrical analysis of the glandular parenchyme and stroma among diabetic and alcoholic patients.

    Science.gov (United States)

    Merlo, Carolina; Bohl, Luciana; Carda, Carmen; Gómez de Ferraris, María Elsa; Carranza, Miriam

    2010-01-01

    Among the agents that cause parotid sialosis, diabetes mellitus type 2 and chronic alcoholism are included. In this study, the morphometrical modifications in the diabetic parotid sialosis were determined to compare them with the histopathological characteristics of alcoholic parotid sialosis. Five parotid biopsy samples obtained from patients with diabetic sialosis, 12 samples from patients with alcoholic sialosis and seven from individuals without these pathologies (control group) were analyzed. A morphometrical study of parotid parenchyme and stroma, using a digital image analyzer attached to an optical microscope, was carried out. Dimensions of serous acini and striated ducts, the area occupied by the fatty tissue, and the number of ducts were recorded. Mean values were compared using the Mann-Whitney U-test (P hyperplasy. Nevertheless, these findings show that the ductal dimensions and the proportion of adipose tissue are variables that allow us to establish histopathological differences between diabetic and alcoholic sialosis.

  15. 依达拉奉防治大鼠颈动脉球囊成形术后血管再狭窄%Experimental study on edaravone in prevention of restenosis in rat common carotid balloon angioplasty

    Institute of Scientific and Technical Information of China (English)

    周海武; 徐平

    2008-01-01

    Objective To investigate edaravane in prevention of restenosis in rat common catery arteries balloon angioplasty and the possible mechanism of this process. Methods Forty male SD rats were randomly divided into 2 groups: treatment group (whose intima was injured by balloon and was given edaravone 3 mg/kg by peritoneal injection, bid) and control group (whose intima was injured by ballon and was given the same volume NS as edaravone). 1, 3, 7, 14 and 28 days after angioplasty, rats were killed and the local arteries were sectioned for analysis of pathological morphology and the expression of matrix metalloproteinase-2 (MMP-2) analyzed by immunohistochemistry. Results Small amounts of smooth muscle cell appeared at the intima of blood vessel 3 days after the artery injured by balloon. Consecutive intima was formed 7 days after artery injury. The intima was even or uneven thickened and the lumen of artery was significant stenosed 14 and 28 days afterwards. In the control group, the intimal area reached (0.240±0.043) mm2, the intima hyperplasy index were 0.52±0.06, stenosis ratio were 30%±9% 14 days afterwards. The intimal area were (0.420±0.063 )mm2, the intima hyperplasy index were 0.67± 0.07, stenosis ratio were 54%±9% on day 28. In the treatment group, the intimal area were (0.063± 0.025)mm2, the intima hyperplasy index were 0.24±0.07, stenosis ratio were 8%±3% after 14 days. The intimal area were (0.116±0.023) mm2, the intima hyperplasy index were 0.38±0.05, stenosis ratio were 16%±4% after 28 days. Compared with control group at the same time, the intimal area (F values were 50.488 and 81.119 respectively, P < 0.05 ), the intima hyperplasy index ( F values were 41.743 and 48.122 respectively, P<0.05) and stenosis ratio (F values were 24.221 and 81.119 respectively, P< 0.05) were decreased in treatment group. The expressions of MMP-2 raised after balloon injury. In control group, the expressions of MMP-2 were 27.16%±7.15% after 3 days, 22.59%±6

  16. 肝脏局灶性结节增生的诊断和治疗%Diagnosis and treatment for focal nodular hyperplasia of the liver

    Institute of Scientific and Technical Information of China (English)

    李涛; 朱继业; 王福顺; 冷希圣

    2016-01-01

    目的 探讨肝脏局灶性结节增生(focal nodular hyperplasis,FNH)的临床诊断和治疗方法.方法 回顾性分析36例FNH患者的临床资料.所有患者均行血清学和影像学检查.对于诊断不明确、有明显临床症状者以及虽明确诊断FNH但病灶进行性增大者行相应的手术治疗.确诊为FNH无明显临床症状者随诊观察.结果 36例患者中男22例,女14例.29例患者无明显临床症状.33例患者肝功能正常,HBsAg阳性1例.所有患者肿瘤标志物均正常.术前B超检查均未明确诊断.术前CT检查10例,诊断FNH 4例.术前MRI检查12例,诊断FNH 7例.CT联合MRI检查14例,诊断FNH 10例.手术切除30例,B超引导下经皮射频消融治疗2例,术后随访14 ~ 72个月无复发.4例患者保守治疗,定期影像学观察,随访3 ~ 22个月,病灶无明显增大. 结论 FNH临床表现无特异性.联合CT和MRI检查有助于明确诊断.对于诊断不明确、有明显临床症状者需手术治疗,射频消融是一种疗效肯定的微创治疗方法.FNH预后良好.%Objective To investigate the diagnosis and management of focal nodular hyperplasis (FNH).Methods Clinical data of 36 FNH patients who were admitted to the Peking University People's Hospital from February 2009 to August 2015 were retrospectively analyzed.All the patients received serological and imaging examinations.Appropriate surgical treatment was done on symptomatic patients and those in which diagnosis was established but lesions progressly enlarged.Conservative treatment was done on FNH confirmed patients without symptoms.Results Of the 36 patients,22 were male and 14 were female.29 patients had no obvious clinical symptoms.The liver function was normal in 33 patients,HBsAg positive in 1 case.Serum tumor markers were normal in all patients.B ultrasound made no identification of FNH in all patients.CT was done in 10 cases,and FNH was suggested in 4 cases.MRI done on 12 cases and the diagnosis of FNH was made in

  17. 促红细胞生成素在铅镉联合胁迫致雏鸡贫血中的作用%Roles of Erythropoietin in Chicken Anemia Induced by Lead and Cadmium

    Institute of Scientific and Technical Information of China (English)

    张陆; 夏士亮; 李金龙; 徐世文

    2011-01-01

    The purpose of this experiment was to study on the roles of erythropoietin (EPO) in chicken anemia induced by lead and cadmium. Sixty 7-day old chickens, which were administered daily per os, were divided into 4 groups: the control group, the lead group, the cadmium group and the lead-cadmium group. In the lst, 3rd, 7th day, we tested the hematological parameters and the reticulocyte count, observed the image of bone marrow, meantime we also detected the eryth-rocyte membrane ATPase activity, the RBC osmotic fragility and the blood serum EPO content, respectively. The results showed that either lead or cadmium alone could induce anemia in chickens, firstly the reticulocyte count increased, bone marrow hyperplasied, but then the reticulocyte count decreased, bone marrow hyperplasy restrained, both the erythrocyte membrane Na+-K+-ATPase and Ca2+-Mg2+ -ATPase activities decreased, the RBC osmotic fragility increased, while the content of EPO firstly increased and then decreased. Moreover the combined toxicity group had the same but more remarkable toxic effects than the single toxicity groups (P<0. 01 or P< 0.05). It is suggested that lead and cadmium alone or combined all could cause aplastic anemia and hemolytic anemia in chicken, and have synergic effects with both lead and cadmium, which indicated that EPO participated in the chicken anemia induced by lead and cadmium.%为研究促红细胞生成素(EPO)在铅镉联合胁迫致雏鸡贫血中的作用,选用60只7日龄公雏鸡,平均分为对照组、铅组、镉组和铅镉组,每日经口灌服染毒,分别于第1、3、7天染毒后,检测雏鸡血液学指标和网织红细胞数量,并进行骨髓象的观察及红细胞膜ATP酶活性、红细胞渗透脆性和血清EPO含量的检测.结果表明铅镉单独染毒使雏鸡发生贫血,网织红细胞数量先增加后降低,骨髓象增生先活跃后受抑制,红细胞膜Na+ -K+ -ATPase、Ca2+-Mg2+-ATPase活性降低,红细胞渗透脆性增加,血

  18. Spiral-CT angiography after intraarterial iliac stent placement; Spiral-CT-Angiographie nach arterieller iliakaler Stentapplikation

    Energy Technology Data Exchange (ETDEWEB)

    Freund, M. [Kiel Univ. (Germany). Klinik fuer Radiologische Diagnostik; Palmie, S. [Kiel Univ. (Germany). Klinik fuer Radiologische Diagnostik; Wesner, F. [Kiel Univ. (Germany). Klinik fuer Radiologische Diagnostik; Heller, M. [Kiel Univ. (Germany). Klinik fuer Radiologische Diagnostik

    1995-10-01

    In a prospective study 32 patients underwent CT-A after stent placement in the iliac arteries. The vascular morphology was analyzed regarding neointimal hyperplasia and calcification pattern. The results were compared with those of clinical findings (walking distance), Doppler ultrasound (ankle-brachial index) and DSA. All 47 stents were visible and patent (100%). One misplacement was identified. A good correlation was found between an improved ankle-brachial index and CT-A (88.5%) and extension of the walking distance and CT-A (92.3%). Concerning location, number and grade of stenoses the results between CT-A and DSA matched in 42.1%. An exact mapping of calcified plaques was possible in all cases. (orig./MG) [Deutsch] Nach perkutaner transluminaler Angioplastie (PTA) und Stenteinlage wurden 32 Patienten prospektiv mittels CT-A untersucht. Es erfolgte eine Analyse der Gefaessmorphologie hinsichtlich neointimaler Hyperplasien und Verkalkungsmuster. Weiterhin wurden die Ergebnisse mit denen der intraarteriellen digitalen Subtraktionsangiographie (i.a. DSA), dem klinischen Befund (Gehstrecke) und der Doppler-Ultraschalluntersuchung (Arm-Knoechel-Index/AKI) verglichen. Alle 47 Stents konnten in der CT-A exakt lokalisiert und als offen identifiziert werden (100%). Eine Stentfehllage wurde diagnostiziert. Der Nachweis neointimaler Hyperplasie gelang aufgrund von Metallartefakten im Stentniveau nicht. Verkalkungen waren in allen Faellen nachweisbar. Eine Uebereinstimmung zwischen DSA und CT-A hinsichtlich des Schweregrades, der Anzahl und Lokalisation von Stenosen fand sich nur in 42,1%. In 88,5% der Faelle bestand eine Uebereinstimmung zwischen CT-morphologischem Befund und verbessertem AKI, in 92,3% mit verlaengerter Gehstrecke. (orig./MG)

  19. Vertebral Development in Paleozoic and Mesozoic Tetrapods Revealed by Paleohistological Data.

    Science.gov (United States)

    Danto, Marylène; Witzmann, Florian; Fröbisch, Nadia B

    2016-01-01

    Basal tetrapods display a wide spectrum of vertebral centrum morphologies that can be used to distinguish different tetrapod groups. The vertebral types range from multipartite centra in stem-tetrapods, temnospondyls, and seymouriamorphs up to monospondylous centra in lepospondyls and have been drawn upon for reconstructing major evolutionary trends in tetrapods that are now considered textbook knowledge. Two modes of vertebral formation have been postulated: the multipartite vertebrae formed first as cartilaginous elements with subsequent ossification. The monospondylous centrum, in contrast, was formed by direct ossification without a cartilaginous precursor. This study describes centrum morphogenesis in basal tetrapods for the first time, based on bone histology. Our results show that the intercentra of the investigated stem-tetrapods consist of a small band of periosteal bone and a dense network of endochondral bone. In stereospondyl temnospondyls, high amounts of calcified cartilage are preserved in the endochondral trabeculae. Notably, the periosteal region is thickened and highly vascularized in the plagiosaurid stereospondyls. Among "microsaur" lepospondyls, the thickened periosteal region is composed of compact bone and the notochordal canal is surrounded by large cell lacunae. In nectridean lepospondyls, the periosteal region has a spongy structure with large intertrabecular spaces, whereas the endochondral region has a highly cancellous structure. Our observations indicate that regardless of whether multipartite or monospondylous, the centra of basal tetrapods display first endochondral and subsequently periosteal ossification. A high interspecific variability is observed in growth rate, organization, and initiation of periosteal ossification. Moreover, vertebral development and structure reflect different lifestyles. The bottom-dwelling Plagiosauridae increase their skeletal mass by hyperplasy of the periosteal region. In nectrideans, the skeletal mass

  20. 用于主动脉支架的NiTi合金丝材的性能改善%Performance Improvement of the NiTi Alloy Wire Used for Aortic Stent-graft

    Institute of Scientific and Technical Information of China (English)

    朱清; 袁振宇; 冯睿

    2011-01-01

    为了改善主动脉支架的物理性能和生物相容性,对支架制备过程中的NiTi合金丝材热处理和电化学抛光过程进行研究.结果表明,热处理不仅可以有助于支架段的定型,而且可以提高丝材机械性能.热处理温度480℃x7min+510℃x7min时最为理想,可以获得较好的物理性能.电化学抛光可以改善丝材表面质量,显著提高丝材的疲劳寿命,并减少附壁血栓形成和内皮增生.%In order to improve the physical properties and biocompatibility of the aortic stent-graft, the effects of heat treatment and electrochemical polishing on nickel-titanium (NiTi) alloy wire during the stent-graft preparation were studied. It is found that heat treatment could help shaping the stent-graft and enhance the mechanical properties of the NiTi wire. The ideal heat-treatment process is heating at 480℃ and 510℃ for 7 min, respectively. By electrochemical polishing, the surface quality and fatigue life of the wire is highly improved. Meanwhile, electrochemical polishing results in reduction of the possibility of the mural thrombus formation and endothelial hyperplasy.

  1. Das gastral differenzierte Adenom (pyloric gland adenoma. Fact or Fiction?

    Directory of Open Access Journals (Sweden)

    Vieth M

    2005-01-01

    Full Text Available Das gastral differenzierte Adenom des Magens wird in der englischen Literatur als "pyloric gland adenoma" bezeichnet. Der erste Bericht zu dieser Entität erschien 1976 als Buchbeitrag, allerdings wurde die Läsion damals als eine Adenom-artige Hyperplasie mukoider Drüsen beschrieben. Erst ab 1990 wurden Pylorusdrüsen-Adenome korrekt als gastral differenzierte Adenome identifiziert und diagnostische Kriterien entwickelt. Die Bezeichnung Pylorusdrüsen-Adenom spiegelt die Entstehung aus den tiefen gastralen Drüsenverbänden wieder. Sicher sind die Pylorusdrüsen-Adenome bereits im Routine-HE-Präparat zu diagnostizieren und durch die Immunhistochemie zu bestätigen. Typischerweise exprimieren die Pylorusdrüsen-Adenome Mucin 6, das sonst nur im tiefen Drüsenkörper gefunden werden kann, über die gesamte Breite der Läsion, oft bis zur Oberfläche. Das oberflächliche Mucin 5AC ist oft nur auf eine schmale oberflächliche Zone beschränkt; die Expression kann jedoch stark variieren. Eine Kombination mit Anteilen gewöhnlicher tubulärer Adenome (intestinale Differenzierung kann beobachtet werden. Überproportional häufig ist die Magen-Corpusschleimhaut älterer Patientinnen mit Autoimmungastritis betroffen. Die Häufigkeit von Pylorusdrüsen-Adenomen wird mit 2,7 % aller Magenpolypen angegeben und ist damit nicht so selten wie vermutet. Die wenigen vorhandenen Publikationen zu diesem Thema deuten darauf hin, daß diese Entität meist fehlinterpretiert wird. Pylorusdrüsen-Adenome können im gesamten Gastrointestinaltrakt entstehen. Die klinische Bedeutung liegt in der hohen Rate (30 % der malignen Entartung. Allerdings handelt es sich hierbei vorwiegend um hochdifferenzierte Frühkarzinome mit entsprechend guter Prognose nach endoskopischer Abtragung.

  2. Primärer Hyperaldosteronismus - die häufigste monokausale Ursache der "essenziellen Hypertonie"

    Directory of Open Access Journals (Sweden)

    Tomaschitz A

    2009-01-01

    Full Text Available Der primäre Hyperaldosteronismus (PHA ist durch eine vom Renin-Angiotensin-System entkoppelte, inadäquat gesteigerte Aldosteronproduktion charakterisiert, die durch Kochsalzbelastung nicht ausreichend supprimierbar ist. Die Prävalenz des PHA wird in hypertensiven Patienten auf 5–13 %, sowie bei therapierefraktären hypertensiven Patienten auf 23 % geschätzt. Damit ist der PHA die häufigste Ursache einer sekundären Hypertonie. Zusätzlich ist eine erhöhte Aldosteronkonzentration unabhängig vom Blutdruck mit einem gesteigerten Risiko für die Entstehung einer kardiovaskulären Erkrankung, den plötzlichen Herztod, die linksventrikuläre Hypertrophie, eines Schlaganfalls, einer intrazerebralen Blutung, einer Niereninsuffizienz, einer Atherosklerose, eines gesteigerten Gefäßremodellings und des metabolischen Syndroms assoziiert. Die Ursache eines PHA ist in mehr als 95 % eine bilaterale Nebennierenrindenhyperplasie (idiopathischer Hyperaldosteronismus [IHA] oder ein Aldosteron-produzierendes Adenom (APA der Nebenniere. Der diagnostische Ablauf des PHA gliedert sich in drei Teile: (1 Screening, (2 Bestätigungstest und (3 Subtypenevaluierung (CT-Untersuchung und Nebennierenvenensampling. Die Aldosteron-Renin-Ratio- (ARR- Bestimmung ist der derzeit empfohlene Screeningtest bei Verdacht auf einen PHA. Durch unterschiedliche Vortestbedingungen und Medikamente können jedoch falsch positive und falsch negative Untersuchungsergebnisse resultieren. Entsprechend einer Kosten-Nutzen-Analyse wird derzeit nur in bestimmten Gruppen hypertensiver Patienten ein PHA-Screening empfohlen. Aufgrund der zahlreichen organschädigenden Aldosteron- induzierten Effekte wäre jedoch ein Screening aller hypertensiven Patienten zu überlegen. Nach einer unilateralen laparoskopischen Adrenalektomie (bei APA oder einer seltenen unilateralen Hyperplasie kann bei 30–60 % der Patienten eine Verbesserung der Blutdrucksituation erzielt werden. Bei Patienten mit einem

  3. 植物性雌激素对子宫内膜及异位子宫内膜的影响%Influence of Phytoestrogen on Endometrium and Ectopic Endometrial Focus

    Institute of Scientific and Technical Information of China (English)

    吉梅; 陈超; 林流芳; 刘玉环; 蔡在龙; 俞超芹

    2012-01-01

    Phytoestrogens (Pes) is a group of natural non-steroid compound which displays estrogen-like activity because of their structural similarity to endogenous estrogens and exhibits high affinity binding to estrogen receptor(ER), which have two-way adjustment to endogenous estrogens. Researches have implied that phytoestrogens exert benificial roles in relief of perimenopausal syndrome, meanwhile, they will not cause complicated hyperplasy and canceration of endometrial. Phytoestrogens can also depress the onset risk of endometrial cancer. They exert antitumous effect at some extent. In addition, phytoestrogens can inhibit growth of ectopic focus without side effects such as osteoporosis in endometriosis through its weak estrogenic activity, which will be a gospel to the patients who are suffering endometriosis.%植物性雌激素(phytoestrogens,PEs)是一类结构及生物学活性类似于雌激素的天然非甾体类化合物,可与雌激素受体结合,对内源性雌激素起双向调节作用.研究表明,植物雌激素可以缓解妇女围绝经期相关症状,且不会引起子宫内膜的复杂型增生及癌变;植物雌激素还能降低子宫内膜癌的发病风险,具有一定抗癌作用;此外,植物雌激素通过其弱的雌激素活性,既能抑制体内异位病灶的生长又能避免发生骨质疏松等副作用,将会给子宫内膜异位症(EMs)患者带来福音.

  4. Bone scintigraphy in the treatment planning for hemimandibular elongation; Die Skelettszintigraphie bei der Therapieplanung der hemimandibulaeren Elongation

    Energy Technology Data Exchange (ETDEWEB)

    Kerscher, A. [Kiel Univ. (Germany). Klinik fuer Mund-, Kiefer- und Gesichtschirurgie; Fleiner, B. [Kiel Univ. (Germany). Klinik fuer Mund-, Kiefer- und Gesichtschirurgie; Bohuslaviski, K.H. [Kiel Univ. (Germany). Klinik fuer Nuklearmedizin; Clausen, M. [Kiel Univ. (Germany). Klinik fuer Nuklearmedizin

    1995-06-01

    Darstellung pathophysiologischer Vorgaenge liefert die Skelettszintigraphie eine Entscheidungsgrundlage fuer die Therapieplanung der hemimandibulaeren Hyperplasie. (orig.)

  5. Screening Method of Treatment of Prostatic Hyperplasia Drug%防治前列腺增生症药物筛选方法的探讨

    Institute of Scientific and Technical Information of China (English)

    汤佩佩; 苗明三

    2012-01-01

    Objective;To investigate the screening method of treatment of prostatic hyperplasia drug. Method:through the integration of the research literature on benign prostatic hyperplasia knowledge of etiology and pathogenesis, summary drug research of prevention and treatment of prostatic hyperplasia in the last ten years,, summarizes the a variety of ways of pharmacological interventions for benign proslatic hyperplasia. Results;This paper puts forward the animal models of establishment and clinical closer to the proslatic hyperplasi-a,for further screening prostaiie hyperplasia therapeutic drugs and development of new drugs to provide ideas,and provide new ideas and methods for the relevant clinical studies. Conclusion; Summarize the screening method. Of prevention and treatment of benign prostatic hyperplasia drug.%目的:探讨防治前列腺增生症药物筛选方法.方法:通过整合各研究文献对前列腺增生症病因病机的认识,综述近10a来防治前列腺增生症药物的有关文献,总结出药物干预前列腺增生症的各种途径.结果:提出建立与临床更接近的前列腺增生症的动物模型,为进一步筛选前列腺增生症治疗药物和开发新药提供思路,并为相关临床研究提供新的思路和方法.结论:总结出防治前列腺增生药物的筛选方法.

  6. Intervention of plastic surgery for emergency facial soft tissue injury%急诊面部软组织创伤的整形外科干预

    Institute of Scientific and Technical Information of China (English)

    孙秀锋; 郑妍丽; 姜涛; 王洪燕

    2011-01-01

    [目的]探讨应用整形外科原则和技术,处理急诊面部软组织创伤的方法和经验.[方法]选择急诊面部软组织创伤病例320例,采用整形外科原则和技术行清创及Ⅰ期缝合,观察治疗效果.[结果]伤口Ⅰ期愈合,无明显瘢痕增生,无功能障碍,不需要Ⅱ期修复,美容效果良好.[结论]应用整形外科基本原则和技术处理面部急性软组织创伤,可获得满意的美容效果,值得推广应用.%[Objective] To explore the clinical method of treating emergency facial soft tissue trauma with plastic surgical principles and techniques. [ Methods] The emergency facial soft tissue injuries of 320 patients were selected. They had been debrided and repaired primarily with plastic surgical principles and techniques. Healing effects were observed. [ Results] All cases were primary healing. There were no obvious hyperplasy scars and functional disturbance. Second stage reparation was not required. The cosmetic effect was perfect. [ Conclusion] It is a satisfactory and effective method to treat emergency facial soft tissue trauma with plastic surgical principles and techniques,which can be recommended to all the surgeons.

  7. CLINICAL OBSERVATION ON 60 CASES OF BENIGN HYPERPLASIA OF PROSTATE TREATED BY INJECTION OF "CHUAN-SHEN-TONG" INJECTIO INTO HUIYIN (CV 1)

    Institute of Scientific and Technical Information of China (English)

    WANG Runs-heng; GUO Xiao-chuan

    2005-01-01

    Objective:To observe the therapeutic effect of injection of "Chuan-Shen-Tong" Injectio 川参通注射液 at Huiyin 会阴 CV 1 on benign hyperplasia of prostate. Methods: 60 cases of benign hyperplasia of prostate patients were evenly randomized into treatment group and control group. Those of treatment group were treated with injection of "Chuan-Shen-Tong" Injectio composed of Rhizoma Ligustici Chuanxiong, Radix Salviae Miltiorrhizae, etc. For relieving hyperplasis of prostate, 4 mL/acupoint into Huiyin CV 1 and the other 60 cases of control group were treated by oral administration of Hytrin 1 mg/d in the 1st week and increasing 1 mg/3 d, 4 mg at most. After 28 days' treatment, their therapeutic effects were compared. Results: After treatment, of each 60 cases in treatment and control groups, 11 18.3% and 11 11.7% were controlled in their symptoms, 25 41.7% and 16 26.7% had marked improvement, 18 30.0% and 17 28.3% had improvement, and 6 10.0% and 20 33.3% failed, with the effective rate and the markedly effective rate being 90.0% and 66.7% in the treatment group and 66.7% and 38.3% in the control group respectively. The therapeutic effect of treatment group was significantly superior to that of control group P<0.01 and P<0.05. Conclusion: The therapeutic effect of point-injection of "Chuan-Shen-Tong" for benign hyperplasia of prostate is better than that of oral administration of Hytrin.

  8. L’obésité : aspects physiologiques, cellulaires et moléculaires

    Directory of Open Access Journals (Sweden)

    Ferre Pascal

    2003-03-01

    Full Text Available L’obésité est devenu un problème majeur de santé publique avec une prévalence qui dépasse les 30 % dans certaines sociétés occidentales. L’obésité est un reflet du développement excessif du tissu adipeux lié à un stockage massif de lipides sous forme de triglycérides (hypertrophie et hyperplasie adipocytaires et due à un déséquilibre de la balance énergétique (apport\\\\dépenses caloriques. Pour perdre du poids, il faut alors augmenter les dépenses ou diminuer les apports énergétiques. Bien qu’il existe des mécanismes de régulation de la prise alimentaire, leur efficacité dans le sens du stockage est bien plus grande que dans le sens du déstockage. Chez l’homme une régulation de la dépense énergétique qui permettrait de brûler les calories en excès ne semble pas développée. En résumé, nous sommes programmés pour stocker et non pour dépenser, ce qui aurait pu représenter un avantage évolutif important en cas de périodes de famines, seuls survivant alors les plus « gras ». A l’heure actuelle, il n’existe pas de traitement pharmacologique efficace de l’obésité et il paraît donc plus raisonnable d’essayer de prévenir que de guérir.

  9. Primary EBV-positive Hodgkin's lymphoma of the CNS under azathioprine treatment. Case report and review of the literature

    Energy Technology Data Exchange (ETDEWEB)

    Henkenberens, Christoph; Christiansen, Hans [Medizinische Hochschule Hannover, Klinik fuer Strahlentherapie und Spezielle Onkologie, Hannover (Germany); Franzke, Anke [Medizinische Hochschule Hannover, Klinik fuer Haematologie, Haemostaseologie, Onkologie und Stammzelltransplantation, Hannover (Germany); Raab, Peter [Medizinische Hochschule Hannover, Institut fuer Diagnostische und Interventionelle Neuroradiologie, Hannover (Germany); Oschlies, Ilske; Klapper, Wolfram [Universitaetsklinikum Schleswig-Holstein, Institut fuer Pathologie, Sektion Haematopathologie, Kiel (Germany)

    2014-09-15

    Therapie und Prognose dieser seltenen Entitaet bekannt. Wir praesentieren einen entsprechenden Fallbericht mit einer Literaturuebersicht. Ein 47-jaehriger Kaukasier mit persistierendem Stirnkopfschmerz und unspezifischem Schwindel praesentierte in radiologischen Untersuchungen mehrere nodulaere Raumforderungen im Kleinhirn mit Kontakt zum 4. Ventrikel. Seine Krankengeschichte umfasste eine Multiple Sklerose, die seit 20 Jahren mit dem Immunsuppressivum Azathioprin behandelt wurde. Das weitere Staging ergab keine weiteren malignitaetsverdaechtigen Laesionen. Die tumoroesen Laesionen wurden vollstaendig reseziert. Die Immunhistopathologie zeigte ein Epstein-Barr-Virus-assoziiertes klassisches Hodgkin-Lymphom. Die diagnostische Knochenmarkpunktion ergab keinen Hinweis auf eine Lymphombeteiligung. Der Patient zeigte keine B-Symptome. Somit wurde die Lymphomerkrankung des Patienten als Stadium IE A nach der modifizierten Ann-Arbor-Klassifikation fuer Hodgkin-Lymphome klassifiziert. Der Patient erhielt postoperativ eine Chemotherapie gefolgt von einer Bestrahlung der ehemaligen Tumorregion des Kleinhirns. Er erreichte eine Komplettremission, die in der letzten Follow-up-Untersuchung nach 9 Monaten weiter anhielt. Dieser Fallbericht und die Literaturuebersicht legen nahe, dass eine multimodale Behandlung zu guten klinischen Ergebnissen bei primaer intrakraniellem Hodgkin-Lymphom fuehrt. (orig.)

  10. IN SITU BY BRIDIZATION DETECTING L- FORM DNA OF STAPHYLOCOCCUS AUREUS OF LARYNGOCARCINOMA%原位杂交检测喉癌中金葡菌L型DNA

    Institute of Scientific and Technical Information of China (English)

    徐淑秀; 汪万英; 姚敏

    2000-01-01

    目的 探讨喉癌细胞中是否有金葡菌L型DNA原位杂交阳性表达。方法 应用原位核酸杂交技术检测20例喉癌细胞核内金葡菌L型DNA的表达。结果 60%癌细胞核、浆内显示金葡茵L型DNA阳性信号。免疫组化染色(S-P法)金葡菌L型抗原阳性率为75%。革兰氏染色金葡菌L型阳性率为70%。结论 金葡菌L型DNA已进入喉癌细胞内,极有可能与宿主细胞DNA整合,从基因水平上影响细胞增生和癌变,提示金葡菌及其L型感染与喉癌发生和发展可能有密切的关系[6]。%Aim To study whetger there is positive express in situ hybridization of L-form DNA or Staphylococcus aureus in laryngocarcinoma cell. Methods 20 cases of expressnon of L-form DNA of Staphylococcus aureus in laryngocarcinoma karyon were detected with nucleic acid in situ hybridization. Results 60% cancer karyon, cytoplasm display positive signal of Staphylococcus aureus L-form DNA. Positive rate of Staphylococcus aureus L-form antigen is 75% with immunohischemical (s-p) stainipg. The rate is 70% with gram staining. Conclusion Staphylococcus aureus L-form DNA had get into laryngocarcinoma ceells, is great possibly to integrate into host ce11, and influence hyperplasis and canceration of cell from gene level. Staphylococcus aureus and its L-form infection have possibly close relation to happen and development of laryngocarcinoma.

  11. Inducement of Root Hair and the Root Epidermal Transfer Cells during the Formation of Root Nodule in Leguminous Plants%根瘤形成过程中豆科植物根毛和根外层传递细胞的诱发

    Institute of Scientific and Technical Information of China (English)

    林树燕; 吴均章; 韩素芬

    2008-01-01

    The morphology and anatomy of 7 legume species with the rhizobia were investigated. The results showed that the hyperplasy of root hair, root deformation and the development of the root epidermal trans-fer cells were induced by rhizobia. The transfer cells began to develop from the phase of root hair deforma-tion,and they could live until the formation of the nodule. Cell membrane ingrowths were first observed at the initial stage of the root hair deformation,then the wall material gradually deposited and finally transfer cells formed. The development of transfer cells had no relation with the medium whether it was solid or liq-uid. The transfer cell did not exist in the root which was not inoculated by the rhizobia.%对7种豆科植物接种根瘤菌后根部的形态和内部结构进行了研究.结果表明:根瘤菌可诱发根瘤形成部位根段的根毛增生、形变和根外层传递细胞的发育.根外层传递细胞发生在根毛伸长形变时期,一直可持续到根瘤形成,传递细胞壁内突发育过程是先由根表皮细胞外切向壁一侧细胞质膜向细胞质内陷形成囊状壁傍体,次生细胞壁物质在初生壁上沉积并逐渐充满囊状体,最终形成传递细胞典型的壁内突结构.根瘤形成过程中根外层传递细胞的诱发与培养方式(水培、固培)没有直接关系.在不接菌的对照苗的根段内未发现壁内突结构,研究证明豆科植物根外层传递细胞的形成是由根瘤菌诱导所致.

  12. Analysis of breast diseases screening results in tongzhou district, beijing in 2013%2013年北京市通州区乳腺疾病筛查结果分析

    Institute of Scientific and Technical Information of China (English)

    王景; 张璐; 张晓君; 史立晖

    2014-01-01

    Objective To understand the self-care awareness and the prevalence of various breast diseases especially breast cancer of the women in this District in order to provide theoretical basis for the key and periodical screening projects on gynecological diseases prevention and treatment. Methods Using the unified diagnosis standard,unified questionnaire. Methodsbreast examination combined with hand diagnosis,ultrasound,molybdenum target X-ray and pathological examination. Results The screening found 13390 women with mammary gland hyperplasis,551 women with breast fibroadenoma,1878 women with benign breast diseases,3 women with breast cancer precancerous lesions and 4 women with breast cancer.In the correlation study of occupation and breast diseases,the staffs of enterprises and public institutions had the highest proportion of breast diseases,followed by civil servants and teachers, others and peasants. Conclusion The implementation of breast cancer general survey popularizes breast cancer knowledge and promotes women's self-care awareness.%目的:了解本区妇女的自我保健意识及各种乳腺病变尤其是乳腺癌的患病情况,为今后的妇女病防治重点及周期性筛查方案提供理论依据。方法采用统一诊断标准,统一问卷。乳腺检查以手诊、超声检查、钼靶X线检查及病理检查相结合的方法。结果查出乳腺增生13390例;乳腺纤维腺瘤551例;其他乳腺良性疾病1878例;乳腺癌癌前病变3例;乳腺癌4例;在研究职业与乳腺疾病的关系中发现,企事业单位职工患乳腺疾病的比例最高,其他依次为公务员和老师,其他以及农民。结论通过开展乳腺癌普查工作,普及了乳腺癌知识,提高了广大妇女自我保健意识。

  13. Endovascular brachytherapy to prevent restenosis after angioplasty; Endovaskulaere Brachytherapie in der Restenoseprophylaxe nach Angioplastie und Stentimplantation: Eine Uebersicht

    Energy Technology Data Exchange (ETDEWEB)

    Wohlgemuth, W.A.; Bohndorf, K. [Klinikum Augsburg (Germany). Klinik fuer Diagnostische Radiologie und Neuroradiologie

    2003-02-01

    besteht bei Patienten mit erhoehtem Risiko eine Restenose wie beispielsweise einer Rezidivstenose, einer In-Stent-Hyperplasie, langen ueberstenteten Laesionen, einer langen PTA-Strecke, kleinen Restlumina und Patienten mit Diabetes mellitus. Daten aus dem koronaren Stromgebiet legen nahe, dass waehrend der Bestrahlung ein Sicherheitsabstand von mindestens 4-10 mm beidseits der durch PTA traumatisierten Gefaessstrecke eingehalten werden sollte, um Restenosen an den Bestrahlungsraendern zu vermeiden. Zur Prophylaxe einer Spaetthrombosierung nach Bestrahlung wird im koronaren Stromgebiet eine medikamentoese Begleittherapie mit ASS 100 mg und Clopidogrel 75 mg taeglich ueber mindestens 6 Monate nach PTA und 12 Monate nach Stentneumimplantation empfohlen, gesicherte Erkenntnisse fuer periphere Arterien existieren noch nicht. (orig.)

  14. Applie danatomy on the landmark of anterior decompression surgery in cervical vertebrae%颈椎病前路手术减压范围标志的解剖学研究

    Institute of Scientific and Technical Information of China (English)

    韩伟峰; 林欣; 李小光; 崔维; 熊英

    2009-01-01

    Objective: To explore the suitable anatomic marks as safe border of transverse decompression in anterior border of cervical vertebral surgery. Methods: Anatomic data of vertebral artery were measured on 12 adult embalmed cadavers (44 sides), for locating vertebral artery during three-dimensional CT reconstructing. Under the microscope, the distance between bilateral medial borders of longus colli muscles was measured, while the features of vertebral artery, nerve root, uncinate joint were observed and analyzed. Results:The distances between horizontal tangent of anterior vertebral body and anterior transversal foramen, bilateral root of anterior wall of transversal foramens, and bilateral medial borders of iongus colli muscles gradually decreased from downside to upside. The distance between anterior angle oftmcinate process was (17.3±2.92) mm averagely, and dural sac width (16.5±0.42)mm. The distance between the medial border of iongus colli muscles and medial margin of the vertebral artery, medial border of longns colli muscles and median sagittal plane had no significant difference at C4~6 level, however, which had significant difference at C3 and C7 level (P<0,05). Hyperplasia of uncinate joint can be found in senile cadavers, with the most serious case of which covering the vertebral artery completely and pushing it posterolaterally. Conclusions: For anterior approach, it is necessary to analyze image data carefully before the surgery, make sure operation process individually, and consider about the hyperplasy of uncovertebral joint.%目的:探讨颈前路手术减压范围及安全界限的解剖标志.方法:对12具成人尸体标本进行三维CT重建,并测量定位椎动脉所需解剖数据,在显微镜下测量颈长肌内侧缘间距等数据,并观察椎动脉、神经根、钩椎关节及其对应关系.结果:椎体前缘与横突孔前缘水平切线间距离、双侧横突孔内侧壁距离及颈长肌内侧缘间距由下端至上端逐渐

  15. 磁共振扩散加权成像在子宫内膜病变鉴别诊断中的价值%Value of Diffusion-weighted MRI Imaging in Differential Diagnosis of Uterine Endometrial Lesions

    Institute of Scientific and Technical Information of China (English)

    相世峰; 项剑瑜; 王为知; 张淑平; 金鑫行; 王廷昱

    2012-01-01

    Objective To investigate the value of diffusion - weighted imaging( DW1) and apparent diffusion coefficient (ADC) in the differentiation of endometrial carcinomas, endometrial hyperplasia and endometrial polyps and degeneration of uterine sub mucous. Methods Conventional MRI and DWI were preformed in 25 patients with endometrial carcinomas, 6 patients with endometrial hyperplasi-a,4 patients with endometrial polyps-and 1 patients with degeneration of uterine sub mucous. All images were reviewed and apparent diffusion coefficient (ADC) values were measured in all the lesions shown in all endometrial lesions. Results High signal intensity in DWI was showed in 25 cases of endometrial carcinomas, and the mean ADC value was (0.78±0.06)×10-3 mm2/s. 6 cases of endometrial hyperplasia had slightly high signal in DWI,and the average ADC value was (1.41 ± 0. 12)×103 mm2/s.4 cases of endometrial polyps in DWI had slightly high signal, and the average ADC value was (1.33±0.07)×103 mm2/s. 1 cases of degeneration of uterine sub mucous in DWI had the signals,and the ADC value was (2. 19 ±0.25)×103 mm /s. There was no statistically significant difference between endometrial hyperplasia and endometrial polyps is ADC value (P>0.05) ,and the remaining had statistically significant differences (P< 0. 05). Conclusions DWI and ADC value can effectively reflect the diffusion properties of water in different lesions. So it has great value in the differentiation all endometrial lesions.%目的 探讨磁共振扩散加权成像( DWI)以及表观扩散系数(ADC)在子宫内膜癌、子宫内膜增生、子宫内膜息肉及子宫黏膜下肌瘤变性鉴别诊断中的价值.方法 收集经病理证实的子宫内膜癌25例、子宫内膜增生6例、子宫内膜息肉4例、子宫黏膜下肌瘤变性1例,所有病例行常规MRI及DWI检查,测量并比较所有子宫内膜病变的ADC值.结果 25例子宫内膜癌在DWI上均呈明显高信号,平均ADC值为(0.78±0.06)

  16. Effects of burn oil of Chinese medicinal herbs on wound healing in scalded rats%中药烧伤油对大鼠深Ⅱ度烫伤创面愈合的作用

    Institute of Scientific and Technical Information of China (English)

    杨军; 张殿增; 刘晓瑾; 白转丽; 郭敏峰; 王瑞; 彭慧子; 段辉

    2009-01-01

    AIM: To investigate the effects of burn oil of Chinese medicinal herbs on wound healing in scalded rats. METHODS: Three deep-Ⅱ-degree circular skin wounds with a diameter of 2.5 cm were prepared in the back of rats and were treated respectively with burn oil of Chinese medicinal herbs, zinc sulfadiasine cream and matrix ointment 1 time per day. The healing of the wounds was observed. The wound tissue samples were harvested at different times for histopathological examination and the content of hydroxyproline, type Ⅰ/Ⅱ collagen ratio and the fibrocyte eyele of the dermal wound were detected by ELISA assay and flow cytometry. RESULTS : The application of burn oil of Chinese medicinal herbs reduced the swelling and effusion and shortened the healing time of the wound with no wound infection. Pathological examination showed that bum oil of Chinese medicinal herbs alleviated topical inflammation. All layers of derma were well-differentiated. Effect of hydroxyproline and wound type Ⅰ/Ⅲ collagen ratio showed that bum oil of Chinese medicinal herbs promoted the collage hyperplasy of wounds and palliated scars. The observation of the fibrocyte cycle showed that burn oil of Chinese medicinal herbs promoted the dermal fibrocyte proliferation. CONCLUSION: Burn oil of Chinese medicinal herbs promotes the wound healing in scalded rats.%目的:探讨中药烧伤油对大鼠深Ⅱ度烫伤创面愈合的影响.方法:制备深Ⅱ度大鼠背部皮肤圆形创面,直径2.5 cm,共3个,行同体对照实验.分别外用烧伤油,磺胺嘧啶锌软膏和基质软膏,1次/d.观察创面愈合情况,留取不同时相的创面组织,进行组织病理学检查,创面羟脯氨酸含量检测,ELISA法测定创面Ⅰ/Ⅱ型胶原比例和流式细胞仪测定创面真皮成纤维细胞周期.结果:外用烧伤油使创面肿胀和渗出减轻,无感染迹象及创面愈合时间缩短.病理形态学观察发现烧伤油组创面的局部组织炎症

  17. Anatomical study of Racosperma (ex-Acacia mangium tissues cultured in vitro

    Directory of Open Access Journals (Sweden)

    N. K. Takemori

    2000-01-01

    Full Text Available In order to achieve adventitious shoot regeneration from young tissues of Racosperma mangium, several combinations of growth regulators were tested. Kinetin (KIN and a -naphthalenacetic acid (NAA, thidiazuron (TDZ and NAA or indole-3-butyric acid (IBA, 4-CPPU and 2,4-dichlorophenoxyacetic acid (2,4-D were added to basic medium composed of MS salts, MS vitamins and 3% sucrose. Sections of hypocotyls and cotyledons of young seedlings were cultivated on these media. Calli developed on different media and, after two to three months, some of them regenerated organized structures. Histological studies revealed hypertrophy and hyperplasy of medular and cortical parenchyma cells of hypocotyl and cotyledon parenchyma. Formation of meristematic cells and traqueary elements from parenchyma was observed during in vitro culture. In some cases, nodules of traqueary elements were formed. The highest differentiation into meristematic cells was found in cotyledon tissues cultured on 4-CPPU (8.07 µM and 2,4-D (1.13 µM.Várias combinações de reguladores do crescimento foram aplicadas a tecidos jovens de Racosperma mangium com o propósito de induzir a regeneração de brotos adventícios. Cinetina (KIN e ácido naftalenoacético (NAA, tidiazuron (TDZ e NAA, N-(chloro-4-piridil-N´-fenilurea (4-CPPU e ácido 2,4-diclorofenoxiacético (2,4-D foram adicionados a um meio de base composto por sais minerais, na metade da concentração do meio MS, vitaminas MS e sacarose 2%. Explantes de hipocótilos e cotilédones de plântulas semeadas in vitro foram cultivados nesses meios. A formação de calos foi observada em vários meios. Estruturas organizadas se desenvolveram na presença de diferentes combinações de KIN ou TDZ e NAA quando os calos permaneceram dois a três meses nos mesmos meios. Estudos histológicos mostraram a hypertrofia e hiperplasia das células do parênquima medular e cortical, nos calos formados a partir de hipocótilos como de cotilédones. A

  18. BPH-1通过分泌PGE2上调前列腺间质细胞ERRα的表达%Prostaglandin E2 Mediates Up-regulation of ERRα Expression with BPH-1 Condition Medium in Prostatic Stromal Cells

    Institute of Scientific and Technical Information of China (English)

    苗琳; 石建党; 周颖; 杜小玲; 吴荃; 王克明; 张琚

    2008-01-01

    雌激素受体相关受体α(estrogen receptor-related receptor α,ERRα)是一类可以直接或间接参与雌激素应答反应的孤儿核受体,它与雌激素受体(estrogen receptor,ER)在结构上有很强的同源性.雌激素效应在良性前列腺增生(benign prostatic hyperplasis,BPH)的发生和发展中起着重要的作用.通常,孤儿核受体的转录活性多受一些非经典激素如维生素A衍生物、前列腺素类、固醇的调控.本文研究前列腺上皮细胞分泌的活性因子对间质细胞ERRα表达调控的分子机制.收集前列腺增生上皮细胞系BPH-1和前列腺癌上皮细胞系DU-145的条件培养液(condition medium,CM)培养间质细胞,采用实时定量RT-PCR和Western印迹法检测前列腺间质细胞(prostatic stromal cells,PrSC)中ERRα的表达,筛选CM中影响ERRα表达的活性因子.研究结果显示,BPH-1的CM可以上调ERRα的表达,而DU-145的CM对ERRα的表达没有影响;BPH-1中合成前列腺素E2(prostaglandin E2,PGE2)的限速酶--环氧合酶2(cyclooxygenase-2,COX-2)的mRNA表达水平和PGE2的分泌水平明显高于DU-145中COX-2表达水平和PGE2分泌水平;用经添加COX-2抑制剂NS-398的培养液处理BPH-1,其CM中PGE2的浓度明显下降,并失去了对ERRα表达的上调作用;添加PGE2可上调间质细胞中ERRα的表达.结果表明,BPH-1通过分泌PGE2促进间质细胞ERRα的表达,提示:在良性前列腺增生的发生和发展中,上皮细胞的旁分泌作用可促进间质细胞由ERRα介导的雌激素效应.

  19. 异体脱细胞真皮基质对大鼠反肤瘢痕形成的影响%Experimental study on accelular dermal matrix inhibiting skin scar

    Institute of Scientific and Technical Information of China (English)

    张烨峰; 郑锦标; 白肃; 杨丽娜; 陈楚义; 徐继庆

    2009-01-01

    , measure fibroblast and collagen content by HE and Masson staining,and measure the expression of type I procollagen mRNA from fibroblasts in all specimens by RT-PCR.Results After operation,scar was not found in the ADM experimental group,while linear scarring was found in the control group obviously Under light microscopy,ADM was rebuilt as autologous tissue gradually in wound, and inflammatory cell,contents of fibroblasts(P<0.05)and Collagens (P<0.01) were obviously less than controls.The epithelia and formation and thickness of the collagen looked like normal skin.And the expression of type I procollagens mRNA from fibroblasts also decreased in ADM experimental group.Conclusions Treated as autologous tissue, ADM decreased exudations, inflammatory reaction, and inhibited hyperplasy of fibroblasts and synthesis of collagens.ADM demonstrated advantages in remodeling dermal tissue and reduced scar tissue to near normal as a therapeutic tool.

  20. New biological dermis cover Pelnac® in wound healing of children with severe trauma%人工真皮移植修复儿童严重创伤创面

    Institute of Scientific and Technical Information of China (English)

    田良; 邱林; 傅跃先; 田晓菲; 刘燕; 肖军

    2014-01-01

    BACKGROUND:In recent years, tissue engineering has made great progress, and skin tissue engineering is especialy noteworthy. Artificial dermis (PELNAC) is relatively used widely, but there is a lack of relevant reports on wound repair in children. OBJECTIVE:To investigate the clinical efficacy of Pelnac® METHODS:In a retrospective study, 22 patients with the wound of severe trauma were treated with Pelnac as skin graft dressings on treatment of the wounds of severe trauma in children. ® graft, negative-pressure wound therapy and split-thickness skin graft as experimental group (Pelnac® group), and another 19 patients treated with granulation formation dressing and split-thickness skin graft as control group. We colected data including the graft livability, the required re-operative times and the epithelization time after the skin graft. During the folow-up, the skin color and texture of survival skin, subcutaneous fulness, scar hyperplasia and the joint function were also evaluated. RESULTS AND CONCLUSION: In the Pelnac ® group, the graft livability was up to 90% within 10-14 days after grafting. The secondary split-thickness skin graft was required in two cases in the Pelnac® group and in eight cases in the control group. There was a significant difference in the graft livability (P < 0.05). The average epithelization time after the skin graft was (13.86±3.09) days in the Pelnac® group, which was significant shorter than the control group, (19.10±4.62) days, after the first time operation (P< 0.05). During the 10 months folow-up, the survival skin color and skin elasticity in the Pelnac® group was significantly better than that in the control group (P< 0.05). Better subcutaneous fulness and milder scar hyperplasy in the injured sites were obtained in the Pelnac® group compared with the control gorup. Five cases had certain joint function limitation in the Pelnac® group, compared to 10 cases in the control group, with a significant difference (P < 0

  1. Packing material on outcomes of sinus mucosa with chronic rhinosinusitis after endoscopic sinus surgery%鼻内镜术后不同填塞材料对术后黏膜转归的影响

    Institute of Scientific and Technical Information of China (English)

    许海波; 洪燕丽; 李兆生; 许振跃

    2016-01-01

    Objective To explore the effect of different packing materials on sinus mucosa with chronic rhinosinusitis after endoscopic sinus surgery.Methods A total of 167 patients with chronic rhinosinusitis were divided into the frag-mentable nasal dressing group A(n =93)and the swell sponge group B(n =74).Using Lund-Mackay CT scoring sys-tem,visual analogue scales(VAS)and Lund-Kennedy endoscopic scoring system,all patients were assessed in recover in pre-operation period,and the second week,the fourth week,and the twelfth week after the surgery.The data were analyzed by SPSS18.0 statistics software to compare the differences of outcomes of sinus mucosa .Results There was no difference about Lund-Mackay CT scores,the VAS scores and Lund-Kennedy endoscopic scores in two groups be-fore surgery(P >0.05).About Lund-Kennedy endoscopic scoring,the scores of the two groups presented significant difference(P <0.01).Comparing with the scores of the second week,the scores of group A of the fourth week,and the twelfth week were lower than those of the group B (P <0.01).The VAS scores of group A were all significantly different from those of group B at same period(P <0.01),and the scores of group A at the post-operative 4 and 12 week were lower than those of group B.5 cases of group A and 7 cases of group B had sinus region oedema seriously, ves hyperplasy and polypus recurrence.After individualized treatment,sinus mucosa presented recovery tendency. Conclusion Applying of fragmentable nasal dressing can promote preferable outcomes of sinus mucosa with chronic rhinosinusitis after endoscopic sinus surgery.%目的:探讨鼻内镜手术后,鼻腔不同填塞材料对慢性鼻窦炎患者鼻窦术腔黏膜转归的影响。方法对入选的167例鼻窦炎患者按填塞材料的不同分为纳吸棉组(A 组,n =93)和膨胀海绵组(B 组,n =74)。两组患者均执行同样的入院前治疗,由同一高年资医师手术,并给予相同的术后用药及复查

  2. 前列腺增生症合并膀胱过度活动症相关因素研究%Study of BPH With Coexisting Overactive Bladder Dysfunction

    Institute of Scientific and Technical Information of China (English)

    王国勇

    2013-01-01

    Objective: The aim of this study was to use a systematic schedule ,including urodynamics.to describe the rate of coexisting overactive bladder(OAB) in patients with baldder outlet obstruction(BOO) caused by benign prostatic hyperplasis(BPH).We also identified differences between the paticents with pure BOO compared with BOO combined with OAB(BOO+OAB). Methods:One hundered and five men referred to our clinic due to LUTS were included. Patients with a history that might affect their bladder function were excluded . After cystometry and pressure-flow studies,the patients were divided into pure BOO and BOO+OAB. Of the 79 men .Results:64.6% had pure BOO.BOO+OAB was found in 35.4%. PSA,IPSS, volume ,voided volume , PVR , obstruction grade and OABSS differed significantly between the groups .The patients with BOO+OAB had a higher PSA,IPSS, volume ,OABSS, voided smaller volumes, PVR were smaller and were more obstructed .We found no differences in Age ,Cr or Q-max .There was a strong association between OAB and BOO, the percentage of OAB increasing with increased obstruction. Age ,Cr and Q-max did not predict whether the patients had a combined BOO+OAB or not . Conclusions:These finding indicate that BOO is a progressive disease , which in time causes pronounced obstruction and perhaps in itself contributes to the development of OAB.%目的:系统的通过尿流动力学检查,明确良性前列腺增生症合并膀胱过度活动症的相关因素,以利临床医师明确区分 BPH 的 LUTS症状是单纯 BOO 或 BOO+OAB,以具体病情制定进一步治疗.方法:105例有明确 LUTS 的 BPH 的患者.有影响膀胱功能的其他疾病除外.第一步均进行常规的病史、体格检查和 DRE ,IPSS、OABSS、年龄、血清肌酐、PSA、尿液的常规检查和培养等、B 超测定前列腺体积,第二部行尿流率检查:记录 Qmax、VV、PVR(残余尿量,导尿法);第三步:行尿流动力学膀胱充盈测压和压力-流率测定.第四步:

  3. Expression of apoptosis correlated genes Bcl\\|2 and Bax oncoproteins and its significance in laryngeal squamous cell carcinoma%凋亡相关基因Bcl\\|2 、Bax蛋白在喉鳞癌组织中的表达及其临床意义

    Institute of Scientific and Technical Information of China (English)

    张敏燕; 韩仲明; 张正民; 张向红; 王军; 王琪

    2001-01-01

    Objective: Expression of Bcl\\|2 and Bax oncoproteins was tested in laryngeal squamous cell carcinoma (LSCC) in order to find the relationship between the two genes and LSCC, and to explrore their clinical significance by retrospectively study of pathological and clinical doouments. Methods: Immunohistochemical S\\|P method was emioyed in testing the expression of Bcl\\|2 and Bax oncoproteins in 74 patients with LSCC, 24 laryngeal atypical hyperplasis (LAH) and 24 laryngeal normal membrane (LNM). Results: Bcl\\|2 oncoprotein was mainly expressed in cytoplasm of epithelium cells and a small part of cell membrances were stained, appearing brow or yellow, granular distribution.There were no expression in the cell nuclear and stroma. Bax oncoprotein was expressed in cytoplasm and cell membrane and there were a little expression in stroma, appearing light brown and yellow, granular distribution. Bax was less stained than Bcl\\|2. The positive expression percentages of Bcl\\|2 oncoprotein in LSCC, LAH, LNM tissues were 59.46%,66.67% and 20.83% respectively. The Bcl\\|2 expressions in LSCC, LAH tissues were significantly higher than that in LNM (P<0.05); The positive expression percentages of Bax oncoprotein in these three groups were 56.76%, 50.0% and 66.67% respectively which were no significant difference. The results of Spearman correlated analysis showed that expression of Bcl\\|2 and Bax oncoproteins had no obvious correlations with pathological grade, clinical stage and metastasis of lymph node. Both were correlated only with smoking. Conclusions: The imbalance of Bcl\\|2/Bax mainly induced by the high expression of Bcl\\|2 oncoprotein played an important role in the development of LSCC and LAH, Bcl\\|2 may act as a reference index in judging the biological speciality of LSCC; Expressions of Bcl\\|2 and Bax oncoprotein had obvious corelation with smoking in LSCC, indicating Bcl\\|2 and Bax genes may be a target of carcinogenic substance in tobacco; Expression of

  4. The clinical significance of Matrix Metalloproteinase-13 and Galectin-3 in synovial tissues of osteoarthritis w%MMP-13和 Galectin-3在骨性关节炎滑膜组织中的临床意义

    Institute of Scientific and Technical Information of China (English)

    马丽艳; 宋旭东; 张德新; 程潭

    2013-01-01

    osteoarthritis, and to explore their effects in the pathogenesis of osteoarthritis. Methods 42 cases of synovial specimens of osteoarthritis and 12 cases of synovial tissues from healthy young adults who died of unnatural causes or traumatic amputation ( the control group ) were obtained by arthroscopy. The protein expressions of MMP-13 and Galectin-3 in synovial tissues of osteoarthritis were detected by immunohistochemistry. Results Pathological observation showed the synovial cell hyperplasia of osteoarthritis, infiltration of lymphocytes and plasma cells, formation of lymphoid follicles, micrangium hyperplasy and pipe wall thinkening. Immunohistochemistry results showed in synovial tissues of osteoarthritis the MMP-13 protein expression mainly appeared in synovial lining layer cells, inflammatory cells, macrophages and few endothelial cells, whereas in normal synovial tissues the MMP-13 protein expression mainly appeared in synovial lining layer cells. The positive cell rates of MMP-13 in synovial tissues of osteoarthritis and in normal synovial tissues were 0.387±0.042 and 0.053±0.019 respectively. The positive expression rate of MMP-13 in synovial tissues of osteoarthritis was obviously higher than that in normal synovial tissues ( P0.05 ), but were related to the osteoarthritis X-ray clinical staging. The protein expressions of MMP-13 and Galectin-3 in synovial tissues became evident with the increase of the osteoarthritis X-ray clinical staging ( P<0.05 ). Conclusions The expressions of MMP-13 protein and Galectin-3 protein in synovial tissues of osteoarthritis are significantly higher than that in normal synovial tissues, which becomes evident with the increase of the X-ray clinical staging. The findings suggest that they both participate in the pathological process of synovial tissues of osteoarthritis and promote their mutual effects on synovitis. So that, they contribute to treating and assessing the condition of osteoarthritis by clinically detecting the

  5. Preliminary study of the repair process in elastase-induced aneurysms in rabbits%弹力酶诱导兔动脉瘤模型修复过程初步研究

    Institute of Scientific and Technical Information of China (English)

    周加浩; 徐善水; 方兴根; 李真保; 江晓春; 张连富

    2013-01-01

    immunohistochemistry and digital subtraction angiography ( DSA) basis.Results:Pathologic findings revealed formation of red throm-bi at the dome of all aneurysms, disappearance of vascular endothelial cells,complete deletion of the aneurysm wall and abrupt termination of the elastic layer of the parent artery at the level of the aneurysm neck . Although the layer of the tunica intima tended to be proliferative ,yet the elastic lamina was still absent and hyperplasyed collagen fiber and smooth muscle cells were predominant .Immunohistochemistry exposed total nega-tive staining for von Willebrand factor(vWF).The control group demon -strated entire residual of RCCA with a few or absence of thrombosis and integrated structure of vessel wall .DSA examination at day 21 exhibited the mean height of aneurysms by (6.40 ±1.62) mm,width by(4.41 ± 1.15)mm,neck diameter by (5.30 ±2.51)mm and parent vessel diame-ter by (3.99 ±1.59) mm.Conclusion:Combination of simple surgery and porcine pancreatic elastase digestion of the origin of right common ca-rotid artery can develop an aneurysm model mimicking human intracranial aneurysms in pathology and morphology.Self-repair mechanisms and tuni-ca intima proliferation to a certain degree occurs in the early stage after model creation, and the proliferation seems dominant in smooth muscle cells and collagen fibers.No elastic fibers and endothelial cell proliferative repair occur.

  6. 北京市城乡部分社区6种常见老年病流行病学调查%Epidemiological investigation on 6 common diseases among the elderly in some urban and rural areas in Beijing

    Institute of Scientific and Technical Information of China (English)

    高芳堃; 胡建华; 李增金; 刘桂芳; 姜中央; 余存泰; 左涛; 于普林; 郑宏; 杨泽; 谷明明; 张培兰; 洪衣舒; 苏鸿学; 黄魏宁

    2005-01-01

    .SETTING: Beijing Institute of Geriatrics of Beijing Hospital.PARTICIPANTS: Totally 1 558 old people aged ≥60 years living in 10 communities affiliated to Jianguomen district office of the Eastern District of Beijing City, and 8 villages affiliated to Xiangyang and Henan Villagers' Commissions of Shunyi County of Beijing from May 1997 and October 1997 were recruited. In fact, 1 434 persons responded, with a response rate being 92%, 319 males and 498 females came from the city;242 males and 375 females came from the villages.METHODS: Questionnaires were filled up, and physical examinations were conducted in all the elderly. MAIN OUTCOME MEASURES: The 6 common diseases were observed among the elderly: Hyperplasia of prostate, abnormal audition, cartaract ,osteoarthritis, fracture and constipation.RESULTS: Totally 1434 elderly entered the stage of result analysis. ①The incidence of hyperplasia of prostate in the males from the urban areas was lower than that in the rural areas (61.4%,65.7%, P < 0.01 ). ② The incidence of abnormal audition among the elderly from the urban areas was lower than that in the rural areas (53.9%,64.7%,P < 0.01). ③ The incidence of cataract of the two eyes in the elderly from the urban areas was higher than that in the rural areas(46.4%,44.4%, P < 0.01). ④ The incidence of osteoarthropathy in the elderly from the urban areas was higher than that in the rural areas (24.4%,14.9, P < 0.01). ⑤ The incidence of fracture in the elderly from the urban areas was higher than that in the rural areas (14.2%,9.1%, P < 0.05). ⑥ The incidence of constipation of the elderly in urban areas was lower than that in the rural areas(18.2%,23.0%,P < 0.05).CONCLUSION: There is a difference between the elderly from the urban areas and the rural areas in hyperplasis of prostate, abnormal audition, cataract, osteoarthropathy, fracture and constipation, and this is related with the economy, nutrition, medical conditions and cultural

  7. 天麻素对高糖诱导的神经小胶质细胞IL-1β,IL-6表达的影响%Gastrodine represses expression of IL-lβ,IL-6 induced by hyperglycemia in gitter cells

    Institute of Scientific and Technical Information of China (English)

    杜晓红; 毛瑞阳; 刘毅; 李颖; 单亦升

    2009-01-01

    detected by ELISA.The mRNA expression of IL-1β and IL-6 was assessed by Reverse transcription polymerase chain reaction (RT-PCR).Result: The cells were proned to aggregate,some of them with hypertrophy,distinct nucleoli and branch-shaped hyperplasy in HCG group,while less change in Gastrodine groups.The supernatant protein of IL-1β is higher in HCG group than control group (119.53±15.91) ng·L~(-1) vs (25.74±15.72) ng·L~(-1) (P<0.01),but lower in the gastrodine groups than HCG LG (99.32±19.66) ng·L~(-1),MG(76.94±17.16) ng·L~(-1),HG (88.35±18.72) ng·L~(-1) vs (119.53±15.91) ng·L~(-1)(P<0.05).The supernatant protein of IL-6 protein also higher in HCG than control group (393.7±17.51) ng·L~(-1) vs (125.85±36.62) ng·L~(-1) (P<0.01),and lower in the gastrodine groups than HCG (LG 327.06±23.53) ng·L~(-1),MG(217.36±28.81) ng·L~(-1) HG (263.17±22.32) ng·L~(-1) vs (393.7±17.51) ng·L~(-1),P<0.05).The mRNA expression of IL-1β was increased significantly higher in HCG than control group (2.77±0.29) vs (1.13±0.27) (P<0.05),but decreased significantly in gastrodine groups than HCG LGA (2.66±0.31),MGA (2.1±0.41),HGA (2.4±0.28) vs (2.77±0.29) (P < 0.05).The mRNA Expression of IL-6 was higher in HCG than control group (3.97±0.33) vs (1.05±0.13) (P <0.05),but lower in gastrodine groups than HCG LG (3.28±0.3),MG (2.65±0.33),HG (3.04±0.26),vs (3.97±0.33) (P<0.05).Conclusion: Gastrodine can inhibit the expression of IL-1β,IL-6 in cultured BV-2 cells induced by high concentration of glucose.

  8. 应用人工血管移植物转流治疗Leriche综合征78例%Vascular prosthesis graft bypass in the treatment of 78 patients with Leriche syndrome

    Institute of Scientific and Technical Information of China (English)

    王春喜; 陈刚; 梁发启; 彭正

    2008-01-01

    ,USA) is a kind of inert material with low biological response.Its fibers with micropores arrange irregularly.Polyester vascular prosthesis (Intervascular,France) is a kind of knitting polyester products,which is made from high-purity cattle collagen Ⅰ with high biocompatibility.To inlay heparin molecules that can retain 4 weeks into the surface of vessels coated with collagen can prevent thrombogenesis and inhibit hyperplasy of smooth muscle cells (SMC).The type is IGK1608;internal diameter of the bole is 16 nun; internal diameter of the branch is 8 mm.Therapeutic prescriptions were approved by Hospital's Ethics Committee.Follow-up was performed for 3 months-5 years by vascular Color Doppler Sonography,spiral CT angiography (SCTA) three-dimensional reconstruction or digital subtraction angiography (DSA) in hospital.MAIN OUTCOME MEASURES: Biocompatibility of vascular prosthesis and outcome of vascular prosthesis transplantation.RESULTS: Three months after vascular prosthesis transplantation,thrombus was not detected on vascular anastomosis and in vascular prosthesis by Color Doppler Sonography and SCTA.Seventy-seven patients were followed up for over one year,and their stomas were unobstructed.Seventy-six patients were followed up for over five years,and the patency rate of stomas was 89% (68/76).No changes in blood plaque,lencocyte count,haematoglobin or liver and kidney function were found after transplantation.Seven days after surgery,affected extremities with ischemic symptom were improved.Three months later,ischemic symptom disappeared.CONCLUSION: With good biocompatibility of vascular prosthesis,vascular prosthesis transplantation in the treatment of Leriche syndrome has a good outcome following aortofemoral bypass and aortoiliac bypass.

  9. 缺氧诱导因子1α和诱导型一氧化氮合酶基因在缺氧性肺动脉高压大鼠发病过程中的表达%Expressions of hypoxia inducible factor-1 alpha and inducible nitric oxide synthase gene in the development of hypoxic pulmonary hypertension in rats

    Institute of Scientific and Technical Information of China (English)

    何振华; 戴爱国; 张秀峰; 谭小武

    2007-01-01

    arteriole, which were used as remodeling indexes of pulmonary arteriole. HIF-1α and iNOS in the pulmonary arteriole were performed in situ hybridization and immunohistochemical detection. The mean absorbance of pulmonary arteriole wall was used as the relative content of mRNA expression and protein level.MAIN OUTCOME MEASURES: ①Changes in mPAP, RV hypertrophy degree and remodeling indexes of pulmonary arteriole of rats. ② Expressions of HIF-α and iNOS as well as their correlations with mPAP and remodeling indexes of pulmonary arteriole.RESULTS: All the 40 Wistar rats were involved in the final analysis. ①At hypoxia 7 days, mPAP was significantly higher than that of control group (P < 0.05). mPAP reached to the high level at hypoxia 14 days, and then maintained at this level. ② At hypoxia 14 days, RVHI was higher than that of control group (P < 0.05). ③ At hypoxia 7 days, pulmonary arteriole wall was thickened, and lumina became narrowed. There were significant differences in pulmonary arterial wall area/total vascular area, lumina area/total vascular area between hypoxia group and control group (P < 0.05). At hypoxia 14 days, smooth muscle cell density in the intima-media of pulmonary arteriole, and intima-media thickness of pulmonary arteriole were significantly increased (P < 0.05). At hypoxia 21 days, lumina was further narrowed, and obvious smooth muscle hyperplasy was found. HIF-1α and iNOS mRNA expression presented weak-positive in the control group; The relative content of HIF-1α mRNA did not significantly alter at hypoxia 3 and 7 days, but was obviously increased at hypoxia 14 days ,and after this, it maintained at high level. iNOS mRNA was markedly higher than that in the control group at hypoxia 3 days, reached its peak at hypoxia 7 days, was close to the level in the control group at hypoxia 14 days, and enhanced again at hypoxia 21 days, but it was still lower than that at hypoxia 3 days. ⑤HIF-α was mainly found in the intima and media