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Sample records for noa perl yoram

  1. Beginning Perl

    CERN Document Server

    Poe, Curtis 'Ovid'

    2012-01-01

    Everything beginners need to start programming with Perl Perl is the ever-popular, flexible, open source programming language that has been called the programmers’ Swiss army knife. This book introduces Perl to both new programmers and experienced ones who are looking to learn a new language. In the tradition of the popular Wrox Beginning guides, it presents step-by-step guidance in getting started, a host of try-it-out exercises, real-world examples, and everything necessary for a Perl novice to start programming with confidence. Introduces Perl to both new programmers and experienced o

  2. Learning Perl

    CERN Document Server

    Schwartz, Randal; Phoenix, Tom

    2011-01-01

    If you're just getting started with Perl, this is the book you want-whether you're a programmer, system administrator, or web hacker. Nicknamed "the Llama" by two generations of users, this bestseller closely follows the popular introductory Perl course taught by the authors since 1991. This 6th edition covers recent changes to the language up to version 5.14. Perl is suitable for almost any task on almost any platform, from short fixes to complete web applications. Learning Perl teaches you the basics and shows you how to write programs up to 128 lines long-roughly the size of 90% of the Pe

  3. Perl Pocket Reference

    CERN Document Server

    Vromans, Johan

    2011-01-01

    If you have a Perl programming question, you'll find the answer quickly in this handy, easy-to-use quick reference. The Perl Pocket Reference condenses and organizes stacks of documentation down to the most essential facts, so you can find what you need in a heartbeat. Updated for Perl 5.14, the 5th edition provides a summary of Perl syntax rules and a complete list of operators, built-in functions, and other features. It's the perfect companion to O'Reilly's authoritative and in-depth Perl programming books, including Learning Perl, Programming Perl, and the Perl Cookbook..

  4. Perl/Tk Pocket Reference

    CERN Document Server

    Lidie, Stephen

    1998-01-01

    The Perl/Tk Pocket Reference is a companion volume to Learning Perl/Tk, an O'Reilly Animal Guide. Learning Perl/Tk is a tutorial for Perl/Tk, the extension to Perl for creating graphical user interfaces. With Tk, Perl programs can be window-based rather than command-line based, with buttons, entry fields, listboxes, menus, scrollbars, balloons, tables, dialogs, and more. And Perl/Tk programs run on UNIX and Windows-based computers. This small book is a handy reference guide geared toward the advanced Perl/Tk programmer. Novice Perl/Tk programmers will find that its compact size gives th

  5. Games, Diversions & Perl Culture Best of the Perl Journal

    CERN Document Server

    Orwant, Jon

    2010-01-01

    The Perl Journal (TPJ) did something most print journals aspire to, but few succeed. Within a remarkable short time, TPJ acquired a cult-following and became the voice of the Perl community. Every serious Perl programmer subscribed to it, and every notable Perl guru jumped at the opportunity to write for it. Back issues were swapped like trading cards. No longer in print format, TPJ remains the quintessential spirit of Perl--a publication for and by Perl programmers who see fun and beauty in an admittedly quirky little language. Games, Diversions, and Perl Culture is the third volume of Th

  6. Learning Perl Student Workbook

    CERN Document Server

    foy, brian

    2012-01-01

    This is an ebook-only workbook to accompany the 6th Edition of Learning Perl ("the Llama"). If you're just getting started with Perl, this is the book you want-whether you're a programmer, system administrator, or web hacker. This 6th edition of Learning Perl covers recent changes to the language up to version 5.14. Exercises are presented in the first half of the workbook, with the answers in the second. Topics include: Scalar DataLists and ArraysSubroutinesInput and OutputHashesIn the World of Regular ExpressionsMatching with Regular ExpressionsProcessing Text with Regular Expressions10.

  7. Perl for dummies

    CERN Document Server

    Hoffman, Paul

    2011-01-01

    In the days before personal computers, BASIC was the easy programming language to learn, and serious programmers learned FORTRAN or COBOL to do "real work." Today, many people have discovered that Perl is both a great beginning programming language and one that enables them to write powerful programs with little effort. If you're interested in discovering how to program (or how others program), Perl For Dummies, 4th Edition, is for you. If you already know something about programming (but not about Perl), this book is also for you. If you're already an expert programmer, you're still w

  8. Penetration testing with Perl

    CERN Document Server

    Berdeaux, Douglas

    2014-01-01

    If you are an expert Perl programmer interested in penetration testing or information security, this guide is designed for you. However, it will also be helpful for you even if you have little or no Linux shell experience.

  9. Perl Template Toolkit

    CERN Document Server

    Chamberlain, Darren; Cross, David; Torkington, Nathan; Diaz, tatiana Apandi

    2004-01-01

    Among the many different approaches to "templating" with Perl--such as Embperl, Mason, HTML::Template, and hundreds of other lesser known systems--the Template Toolkit is widely recognized as one of the most versatile. Like other templating systems, the Template Toolkit allows programmers to embed Perl code and custom macros into HTML documents in order to create customized documents on the fly. But unlike the others, the Template Toolkit is as facile at producing HTML as it is at producing XML, PDF, or any other output format. And because it has its own simple templating language, templates

  10. Computer Science and Perl Programming Best of Perl Journal

    CERN Document Server

    2002-01-01

    With more than a million dedicated programmers, Perl has proven to be the best computing language for the latest trends in computing and business. While other languages have stagnated, Perl remains fresh, thanks to its community-based development model, which encourages the sharing of information among users. This tradition of knowledge-sharing allows developers to find answers to almost any Perl question they can dream up.And you can find many of those answers right here in Perl Hacks. Like all books in O'Reilly's Hacks Series, Perl Hacks appeals to a variety of programmers, whether you're a

  11. Programming Web services with Perl

    CERN Document Server

    Ray, Randy J

    2003-01-01

    Given Perl's natural fit for web applications development, it's no surprise that Perl is also a natural choice for web services development. It's the most popular web programming language, with strong implementations of both SOAP and XML-RPC, the leading ways to distribute applications using web services. But books on web services focus on writing these applications in Java or Visual Basic, leaving Perl programmers with few resources to get them started. Programming Web Services with Perl changes that, bringing Perl users all the information they need to create web services using their favori

  12. Web, Graphics & PerlTk Programming Best of the Perl Journal

    CERN Document Server

    Orwant, Jon

    2010-01-01

    In its first five years of existence, The Perl Journal (TPJ) became the voice of the Perl community. Every serious Perl programmer subscribed to it, and every notable Perl guru jumped at the opportunity to write for it. TPJ explained critical Perl topics and demonstrated Perl's utility for fields as diverse as astronomy, biology, economics, AI, and games. Back issues were hoarded, or swapped like trading cards. No longer in print format, The Perl Journal remains a proud and timeless achievement of Perl during one of its most exciting periods of development. Web, Graphics & Perl/Tk is the se

  13. Modelo para la alfabetización digital de Yoram Eshet-Alkalai

    OpenAIRE

    Avello-Martínez, Raidell

    2013-01-01

    This review has as objective it describes briefly the skills-based theoretical framework model of digital literacy developed by Yoram Eshet-Alkalai in a series of articles presented in the period 2004-2012. The model is composed by six set of main skills to interact in digital environments, these are: photo-visual skills, repro-duction skills, branching skills, hypertextual navigation skills, infor-mation skills, socio-emotional skills and real-time thinking skills.

  14. Perl Testing A Developer's Notebook

    CERN Document Server

    Langworth, Ian

    2005-01-01

    Is there any sexier topic in software development than software testing? That is, besides game programming, 3D graphics, audio, high-performance clustering, cool websites, et cetera? Okay, so software testing is low on the list. And that's unfortunate, because good software testing can increase your productivity, improve your designs, raise your quality, ease your maintenance burdens, and help to satisfy your customers, coworkers, and managers. Perl has a strong history of automated tests. A very early release of Perl 1.0 included a comprehensive test suite, and it's only improved from th

  15. Perl Modules for Constructing Iterators

    Science.gov (United States)

    Tilmes, Curt

    2009-01-01

    The Iterator Perl Module provides a general-purpose framework for constructing iterator objects within Perl, and a standard API for interacting with those objects. Iterators are an object-oriented design pattern where a description of a series of values is used in a constructor. Subsequent queries can request values in that series. These Perl modules build on the standard Iterator framework and provide iterators for some other types of values. Iterator::DateTime constructs iterators from DateTime objects or Date::Parse descriptions and ICal/RFC 2445 style re-currence descriptions. It supports a variety of input parameters, including a start to the sequence, an end to the sequence, an Ical/RFC 2445 recurrence describing the frequency of the values in the series, and a format description that can refine the presentation manner of the DateTime. Iterator::String constructs iterators from string representations. This module is useful in contexts where the API consists of supplying a string and getting back an iterator where the specific iteration desired is opaque to the caller. It is of particular value to the Iterator::Hash module which provides nested iterations. Iterator::Hash constructs iterators from Perl hashes that can include multiple iterators. The constructed iterators will return all the permutations of the iterations of the hash by nested iteration of embedded iterators. A hash simply includes a set of keys mapped to values. It is a very common data structure used throughout Perl programming. The Iterator:: Hash module allows a hash to include strings defining iterators (parsed and dispatched with Iterator::String) that are used to construct an overall series of hash values.

  16. Noa laev Armastuse tänaval / Anneli Sihvart

    Index Scriptorium Estoniae

    Sihvart, Anneli, 1964-

    2010-01-01

    Tallinnas Laboratooriumi tänaval asuva Ukraina Kultuurikeskuse juht ja ukraina kreeka-katoliku kiriku Tallinna koguduse vanem, kunstnik Anatoli Ljutjuk ootab meistreid ja lapsi voolima Noa laeva loomakujukesi. Grusbeke torni tuleb Tallinna Noa laev ohustatud liikidele. Noa laeva loomisele eelnenud projektidest, pühapäevakoolist, Laboratooriumi tänavast

  17. Modelo teórico de alfabetización digital propuesto por Yoram Eshet-Alkalai

    OpenAIRE

    Avello-Martínez, Raidell

    2013-01-01

    This review has as objective it describes briefly the skills-based theoretical framework model of digital literacy developed by Yoram Eshet-Alkalai in a series of articles presented in the period 2004-2012. The model is composed by six set of main skills to interact in digital environments, these are: photo-visual skills, repro-duction skills, branching skills, hypertextual navigation skills, infor-mation skills, socio-emotional skills and real-time thinking skills.

  18. Pärnu filmifestivali rahva lemmik : laste haridus on ainus tee arenguks / Yoram Honig ; interv. Andris Feldmanis

    Index Scriptorium Estoniae

    Honig, Yoram

    2007-01-01

    XXI Pärnu rahvusvahelise dokumentaal- ja antropoloogiafilmide festivali lõputseremoonial kuulutati välja festivali võidufilmid. Parima filmi grand prix läks režissöör Wojciech Kasperski filmile "Seemned". Rahvahääletus valis parimaks Yoram Honigi filmi "Rahu esimene õppetund". Režissöör oma filmist. Lisatud "XXI Pärnu filmifestivali võitjad"

  19. 33 CFR 160.210 - Methods for submitting an NOA.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Methods for submitting an NOA... Conditions, and Certain Dangerous Cargos § 160.210 Methods for submitting an NOA. (a) Submission to the... the NVMC web site at http://www.nvmc.uscg.gov; (ii) Electronic submission of Extensible Markup...

  20. Perls with Gloria Re-reviewed: Gestalt Techniques and Perls's Practices.

    Science.gov (United States)

    Dolliver, Robert H.

    1991-01-01

    Reviews the filmed interview with Gloria by Perls (1965) which demonstrated some standard Gestalt therapy techniques and presents examples from film. Identifies discrepancies between Perls's description of Gestalt therapeutic processes and his interview behavior. Makes reflections on the inherent difficulties with the concept of the emerging…

  1. A potato NOA gene increased salinity tolerance in Arabidopsis ...

    African Journals Online (AJOL)

    ONOS

    2010-09-06

    Sep 6, 2010 ... in Arabidopsis thaliana salt stress responses and increased its salinity tolerance. Key words: StNOA1 ... (NR)-dependent pathways (Cueto et al., 1996; Delledonne ..... plastome-encoded proteins uncovers a mechanism for the.

  2. Reflections on experimental science Martin Perl

    CERN Document Server

    Perl, Martin Lewis

    1996-01-01

    This is a collection of important lecture and original articles and commentaries by Martin Perl, discoverer of the tau lepton and the third generation of elementary particles, and this year's Nobel Prize winner. This book contains a fascinating and realistic picture of experimental science based on the high energy physics research work carried out by him. Using reprints of his articles with his commentaries, the author presents the various aspects of experimental research in science: the pleasures and risks of experimental work; the pain and frustration with experiments that are useless or fai

  3. 24% efficient PERL structure silicon solar cells

    International Nuclear Information System (INIS)

    Zhao, J.; Wang, A.; Green, M.A.

    1990-01-01

    This paper reports that the performance of silicon solar cells have been significantly improved using an improved PERL (passivated emitter, rear locally-diffused) cell structure. This structure overcomes deficiencies in an earlier PERC (passivated emitter and rear cell) cell structure by locally diffusing boron into contact areas at the rear of the cells. Terrestrial energy conversion efficiencies up to 24% are reported for silicon cells for the first time. Air Mass O efficiencies approach 21%. The first batches of concentrator cells using the new structure have demonstrated significant improvement with 29% efficient concentrator silicon cells expected in the near future

  4. Restoran Noa Miidurannas = Noa Restaurant in the Miiduranna area of Tallinn / Peeter Loo, Jan Skolimowski, Kaspar Kruuse, Tarmo Piirmets ; kommenteerinud Raivo Kotov

    Index Scriptorium Estoniae

    2015-01-01

    Noa restoran Miidurannas Ranna tee 3, valminud 2014. Arhitektid Peeter Loo, Jan Skolimowski, Kaspar Kruuse (Kamp Arhitektid), sisearhitekt Tarmo Piirmets (Pink). Eesti Kultuurkapitali Arhitektuuri sihtkapitali arhitektuuripreemia 2014

  5. Building Tag Clouds in Perl and PHP

    CERN Document Server

    Bumgardner, Jim

    2006-01-01

    Tag clouds are everywhere on the web these days. First popularized by the web sites Flickr, Technorati, and del.icio.us, these amorphous clumps of words now appear on a slew of web sites as visual evidence of their membership in the elite corps of "Web 2.0." This PDF analyzes what is and isn't a tag cloud, offers design tips for using them effectively, and then goes on to show how to collect tags and display them in the tag cloud format. Scripts are provided in Perl and PHP. Yes, some have said tag clouds are a fad. But as you will see, tag clouds, when used properly, have real merits. More

  6. Distancias genéticas en poblaciones del NOA

    Directory of Open Access Journals (Sweden)

    Acreche, Noemí

    1996-01-01

    Full Text Available La mayor parte de los trabajos realizados en nuestro país sobre polimorfismos hematológicos, abordan la necesaria descripción de las poblaciones. Se pone de relieve la importancia de encarar estudios, en base a la valiosa información publicada, que vinculen los grupos con técnicas que permitan realizar nuevas inferencias sobre sus relaciones. Conocidas en gran medida en cuanto a sus manifestaciones culturales, pueden aportar desde lo genético a la comprensión de los procesos microevolutivos ocurridos en una región. Para el NOA, se ha considerado la presencia de comunidades aborígenes incluídas en cuatro familias lingüísticas. Se tendrán en cuenta estos complejos como representativos de afinidades que se establecen a partir de estrechas relaciones entre las etnias, no sólo por la lengua, sino también por las características de sus sistemas productivos, religiosidad y organización. En base a las frecuencias génicas publicadas correspondientes a los siguientes alelos: I*A, I*B, I*O; M, N, S, s; Dia , Dib; P1, P2; C, c; D, d, E, e; Le, le; Fya, Fyb; Jka, Jkb; K y k se construyeron tablas de frecuencias. Se estimaron los coeficientes de distancias genéticas que fueron analizados y posteriormente incluídos en la construcción de un fenograma de los grupos de estudio, mediante agrupaciones (Sahn Cluster secuenciales, aglomerativas, jerárquicas y anidadas. De acuerdo a la información recopilada de las frecuencias de los 25 alelos estudiados en trece poblaciones de aborígenes del NOA y Paraguay, las distancias genéticas obtenidas reflejan los caracteres lingüístico-culturales.

  7. 78 FR 65975 - Notice of Availability (NOA) for Strategic Network Optimization (SNO) Environmental Assessment...

    Science.gov (United States)

    2013-11-04

    ... (NOA) for Strategic Network Optimization (SNO) Environmental Assessment Finding of No Significant... Network Optimization (SNO) Environmental Assessment (EA) Finding of No Significant Impact (FONSI). SUMMARY... interpreted comprehensively to include the natural and physical environment and the relationship of people...

  8. Cloning of nitric oxide associated 1 (NOA1) transcript from oil palm (Elaeis guineensis) and its expression during Ganoderma infection.

    Science.gov (United States)

    Kwan, Yee-Min; Meon, Sariah; Ho, Chai-Ling; Wong, Mui-Yun

    2015-02-01

    Nitric oxide associated 1 (NOA1) protein is implicated in plant disease resistance and nitric oxide (NO) biosynthesis. A full-length cDNA encoding of NOA1 protein from oil palm (Elaeis guineensis) was isolated and designated as EgNOA1. Sequence analysis suggested that EgNOA1 was a circular permutated GTPase with high similarity to the bacterial YqeH protein of the YawG/YlqF family. The gene expression of EgNOA1 and NO production in oil palm root tissues treated with Ganoderma boninense, the causal agent of basal stem rot (BSR) disease were profiled to investigate the involvement of EgNOA1 during fungal infection and association with NO biosynthesis. Real-time PCR (qPCR) analysis revealed that the transcript abundance of EgNOA1 in root tissues was increased by G. boninense treatment. NO burst in Ganoderma-treated root tissue was detected using Griess reagent, in advance of the up-regulation of the EgNOA1 transcript. This indicates that NO production was independent of EgNOA1. However, the induced expression of EgNOA1 in Ganoderma-treated root tissues implies that it might be involved in plant defense responses against pathogen infection. Copyright © 2014 Elsevier GmbH. All rights reserved.

  9. PERLE. Powerful energy recovery linac for experiments. Conceptual design report

    Science.gov (United States)

    Angal-Kalinin, D.; Arduini, G.; Auchmann, B.; Bernauer, J.; Bogacz, A.; Bordry, F.; Bousson, S.; Bracco, C.; Brüning, O.; Calaga, R.; Cassou, K.; Chetvertkova, V.; Cormier, E.; Daly, E.; Douglas, D.; Dupraz, K.; Goddard, B.; Henry, J.; Hutton, A.; Jensen, E.; Kaabi, W.; Klein, M.; Kostka, P.; Lasheras, N.; Levichev, E.; Marhauser, F.; Martens, A.; Milanese, A.; Militsyn, B.; Peinaud, Y.; Pellegrini, D.; Pietralla, N.; Pupkov, Y.; Rimmer, R.; Schirm, K.; Schulte, D.; Smith, S.; Stocchi, A.; Valloni, A.; Welsch, C.; Willering, G.; Wollmann, D.; Zimmermann, F.; Zomer, F.

    2018-06-01

    A conceptual design is presented of a novel energy-recovering linac (ERL) facility for the development and application of the energy recovery technique to linear electron accelerators in the multi-turn, large current and large energy regime. The main characteristics of the powerful energy recovery linac experiment facility (PERLE) are derived from the design of the Large Hadron electron Collider, an electron beam upgrade under study for the LHC, for which it would be the key demonstrator. PERLE is thus projected as a facility to investigate efficient, high current (HC) (>10 mA) ERL operation with three re-circulation passages through newly designed SCRF cavities, at 801.58 MHz frequency, and following deceleration over another three re-circulations. In its fully equipped configuration, PERLE provides an electron beam of approximately 1 GeV energy. A physics programme possibly associated with PERLE is sketched, consisting of high precision elastic electron–proton scattering experiments, as well as photo-nuclear reactions of unprecedented intensities with up to 30 MeV photon beam energy as may be obtained using Fabry–Perot cavities. The facility has further applications as a general technology test bed that can investigate and validate novel superconducting magnets (beam induced quench tests) and superconducting RF structures (structure tests with HC beams, beam loading and transients). Besides a chapter on operation aspects, the report contains detailed considerations on the choices for the SCRF structure, optics and lattice design, solutions for arc magnets, source and injector and on further essential components. A suitable configuration derived from the here presented design concept may next be moved forward to a technical design and possibly be built by an international collaboration which is being established.

  10. Metabolic aspects of Neuronal – Oligodendrocytic - Astrocytic (NOA interactions

    Directory of Open Access Journals (Sweden)

    Ana I Amaral

    2013-05-01

    Full Text Available Whereas astrocytes have been in the limelight on the metabolic glucose interaction scene for a while, oligodendrocytes are still waiting for a place. We would like to call oligodendrocyte interaction with astrocytes and neurons: NOA (neuron – oligodendrocyte – astrocyte interactions. One of the reasons to find out more about oligodendrocyte interaction with neurons and astrocytes is to detect markers of healthy oligodendrocyte metabolism, to be used in diagnosis and treatment assessment in diseases such as Perinatal hypoxic-ischemic encephalopathy and multiple sclerosis in which oligodendrocyte function is impaired, possibly due to glutamate toxicity. Glutamate receptors are expressed in oligodendrocytes and also vesicular glutamate release in the white matter has received considerable attention. It is also important to establish if the glial precursor cells recruited to damaged areas are developing oligodendrocyte characteristics or those of astrocytes. Thus, it is important to study astrocytes and oligodendrocytes separately to be able to differentiate between them. This is of particular importance in the white matter where the number of oligodendrocytes is considerable. The present review summarizes the not very extensive information published on glucose metabolism in oligodendrocytes in an attempt to stimulate research into this important field.

  11. Perl and Apache Your visual blueprint for developing dynamic Web content

    CERN Document Server

    McDaniel, Adam

    2010-01-01

    Visually explore the range of built-in and third-party libraries of Perl and Apache. Perl and Apache have been providing Common Gateway Interface (CGI) access to Web sites for 20 years and are constantly evolving to support the ever-changing demands of Internet users. With this book, you will heighten your knowledge and see how to usePerl and Apache to develop dynamic Web sites. Beginning with a clear, step-by-step explanation of how to install Perl and Apache on both Windows and Linux servers, you then move on to configuring each to securely provide CGI Services. CGI developer and author Adam

  12. Enhanced Abscisic Acid-Mediated Responses in nia1nia2noa1-2 Triple Mutant Impaired in NIA/NR- and AtNOA1-Dependent Nitric Oxide Biosynthesis in Arabidopsis1[W

    Science.gov (United States)

    Lozano-Juste, Jorge; León, José

    2010-01-01

    Nitric oxide (NO) regulates a wide range of plant processes from development to environmental adaptation. Despite its reported regulatory functions, it remains unclear how NO is synthesized in plants. We have generated a triple nia1nia2noa1-2 mutant that is impaired in nitrate reductase (NIA/NR)- and Nitric Oxide-Associated1 (AtNOA1)-mediated NO biosynthetic pathways. NO content in roots of nia1nia2 and noa1-2 plants was lower than in wild-type plants and below the detection limit in nia1nia2noa1-2 plants. NIA/NR- and AtNOA1-mediated biosynthesis of NO were thus active and responsible for most of the NO production in Arabidopsis (Arabidopsis thaliana). The nia1nia2noa1-2 plants displayed reduced size, fertility, and seed germination potential but increased dormancy and resistance to water deficit. The increasing deficiency in NO of nia1nia2, noa1-2, and nia1nia2noa1-2 plants correlated with increased seed dormancy, hypersensitivity to abscisic acid (ABA) in seed germination and establishment, as well as dehydration resistance. In nia1nia2noa1-2 plants, enhanced drought tolerance was due to a very efficient stomata closure and inhibition of opening by ABA, thus uncoupling NO from ABA-triggered responses in NO-deficient guard cells. The NO-deficient mutants in NIA/NR- and AtNOA1-mediated pathways in combination with the triple mutant will be useful tools to functionally characterize the role of NO and the contribution of both biosynthetic pathways in regulating plant development and defense. PMID:20007448

  13. 78 FR 57845 - Notice of Availability (NOA) for Strategic Network Optimization (SNO) Program Environmental...

    Science.gov (United States)

    2013-09-20

    ... Logistics Agency, DoD. ACTION: Notice of Availability (NOA) for Strategic Network Optimization (SNO) Program Environmental Assessment. SUMMARY: The Defense Logistics Agency (DLA) announces the availability of an...-0705 during normal business hours Monday through Friday, from 8:00 a.m. to 4:30 p.m. (EST) or by email...

  14. 78 FR 65300 - Notice of Availability (NOA) for General Purpose Warehouse and Information Technology Center...

    Science.gov (United States)

    2013-10-31

    ... (NOA) for General Purpose Warehouse and Information Technology Center Construction (GPW/IT)--Tracy Site... proposed action to construct a General Purpose Warehouse and Information Technology Center at Defense..., Suite 02G09, Alexandria, VA 22350- 3100. FOR FURTHER INFORMATION CONTACT: Ann Engelberger at (703) 767...

  15. Inversion satellites of isolated Perl vortex in thin film of magnetic superconductor

    CERN Document Server

    Lomtev, A I

    2001-01-01

    The electrodynamics equation is derived for the magnetic field of the Perl isolated vortex, moving by the arbitrary law in the ultrafine magnetic conductor and true for every type of the magnetic ordering in the magnetic subsystem. The magnetic structure of the Perl isolated oscillating vortex in the magnetic conductor fine film is studied. It is shown that the oscillations process and the magnetic subsystem essentially renorm the vortex field as compared to the Perl decision. The new events of the inversion satellite (the inversion forerunners in the front of the vortex and the inversion traces behind it) are forecasted, which may be actually observed in the magnetic optical experiments

  16. TERAPIA GESTÁLTICA DE FRIEDRICH SOLOMON PERLS FUNDAMENTACIÓN FENOMENOLÓGICA-EXISTENCIAL

    Directory of Open Access Journals (Sweden)

    Luis Fernando Velásquez

    2001-01-01

    Full Text Available La primera parte de este documento se ocupa de la vida de Fritz Perls, quien ha sido considerado uno de los principales representantes del Enfoque Humanista en Psicología. En segunda instancia se analiza, de manera clara y precisa, la estrecha relación que existe entre la filosofía existencial, la fenomenología y la Terapia Gestalt propuesta por Perls. Así mismo, el autor revisa los elementos teóricos y prácticos de diversas teorías y escuelas de pensamiento que convergen de manera apropiada en el modelo psicoterapéutico de Perls.

  17. Values in Fritz Perls's Gestalt Therapy: On the Dangers of Half-Truths.

    Science.gov (United States)

    Cadwallader, Eva H.

    1984-01-01

    Examines some of the values in Perls's theory of psychotherapy, which his Gestalt Prayer epitomizes. Argues that at least five of the major value claims presupposed by his psychotherapeutic theory and practice are in fact dangerous half-truths. (JAC)

  18. The one nucleon transfer operator in the microscopic IBM without NOA

    International Nuclear Information System (INIS)

    Barea, J.; Alonso, C.E.; Arias, J.M.

    2014-01-01

    The mapping of the single fermion creation operator (c i † ) onto the Interacting Boson–Fermion space (IBFM) is revisited within the Generalized Seniority scheme. In the original work the Number Operator Approximation (NOA) was used. Here the exact evaluation of the relevant terms using exact values for the fermion matrix elements in the Generalized Seniority scheme is worked out. This provides a new, improved, single particle transfer operator to be used in IBFM

  19. The one nucleon transfer operator in the microscopic IBM without NOA

    Energy Technology Data Exchange (ETDEWEB)

    Barea, J. [Departamento de Física, Universidad de Concepción, Casilla 160-C, Concepción, 4070386 Chile (Chile); Alonso, C.E.; Arias, J.M. [Departamento de Física Atómica, Molecular y Nuclear, Universidad de Sevilla, Apartado 1065, 41080 Sevilla (Spain)

    2014-10-07

    The mapping of the single fermion creation operator (c{sub i}{sup †}) onto the Interacting Boson–Fermion space (IBFM) is revisited within the Generalized Seniority scheme. In the original work the Number Operator Approximation (NOA) was used. Here the exact evaluation of the relevant terms using exact values for the fermion matrix elements in the Generalized Seniority scheme is worked out. This provides a new, improved, single particle transfer operator to be used in IBFM.

  20. Martin L. Perl (1927-2014): A Biographical Memoir

    Science.gov (United States)

    Feldman, Gary; Jaros, John; Schindler, Rafe H.

    2017-10-01

    Particle physicist Martin Lewis Perl was recognized worldwide for his discovery of the τ (tau) lepton. For that achievement he received the 1982 Wolf Prize and shared the 1995 Nobel Prize in Physics. He was also a Fellow of the American Physical Society and a member of the National Academy of Sciences (elected 1981). Martin's distinctive approach to scientific investigation had its origins in his upbringing and in the influence of I. I. Rabi, his graduate advisor at Columbia University. After coming to Stanford University in 1963, Martin sought to understand why there should be two and only two families of leptons: the electron and its associated neutrino; and the muon and the muon neutrino. His discovery of the τ provided evidence for a third family of fundamental leptons. The bottom quark was discovered shortly afterward at the Fermi National Accelerator Laboratory, providing evidence for a third family of quarks. Direct evidence for the τ neutrino came later, thereby completing the third lepton generation, while the discovery of the top quark in 1995 completed the third generation of quarks. These achievements established leptons and quarks as fundamental constituents of matter and, along with the fundamental forces, provided the experimental basis of the "Standard Model," our picture of how all matter is made up and how its components interact. Why there are three and only three families of leptons and quarks remains an unsolved mystery to this day.

  1. TkPl_SU: An Open-source Perl Script Builder for Seismic Unix

    Science.gov (United States)

    Lorenzo, J. M.

    2017-12-01

    TkPl_SU (beta) is a graphical user interface (GUI) to select parameters for Seismic Unix (SU) modules. Seismic Unix (Stockwell, 1999) is a widely distributed free software package for processing seismic reflection and signal processing. Perl/Tk is a mature, well-documented and free object-oriented graphical user interface for Perl. In a classroom environment, shell scripting of SU modules engages students and helps focus on the theoretical limitations and strengths of signal processing. However, complex interactive processing stages, e.g., selection of optimal stacking velocities, killing bad data traces, or spectral analysis requires advanced flows beyond the scope of introductory classes. In a research setting, special functionality from other free seismic processing software such as SioSeis (UCSD-NSF) can be incorporated readily via an object-oriented style to programming. An object oriented approach is a first step toward efficient extensible programming of multi-step processes, and a simple GUI simplifies parameter selection and decision making. Currently, in TkPl_SU, Perl 5 packages wrap 19 of the most common SU modules that are used in teaching undergraduate and first-year graduate student classes (e.g., filtering, display, velocity analysis and stacking). Perl packages (classes) can advantageously add new functionality around each module and clarify parameter names for easier usage. For example, through the use of methods, packages can isolate the user from repetitive control structures, as well as replace the names of abbreviated parameters with self-describing names. Moose, an extension of the Perl 5 object system, greatly facilitates an object-oriented style. Perl wrappers are self-documenting via Perl programming document markup language.

  2. TERAPIA GESTÁLTICA DE FRIEDRICH SOLOMON PERLS FUNDAMENTACIÓN FENOMENOLÓGICA-EXISTENCIAL

    OpenAIRE

    Luis Fernando Velásquez

    2001-01-01

    La primera parte de este documento se ocupa de la vida de Fritz Perls, quien ha sido considerado uno de los principales representantes del Enfoque Humanista en Psicología. En segunda instancia se analiza, de manera clara y precisa, la estrecha relación que existe entre la filosofía existencial, la fenomenología y la Terapia Gestalt propuesta por Perls. Así mismo, el autor revisa los elementos teóricos y prácticos de diversas teorías y escuelas de pensamiento que convergen de...

  3. Clinical Importance of Morphological Appearance of Seminiferous Tubules During MicroTESE in NOA Cases

    Directory of Open Access Journals (Sweden)

    A. H. Haliloglu

    2005-12-01

    Full Text Available Design: Clinical study. Setting: Research Center on Infertility, Ankara University; and Urology Department. Patients: 65 men with nonobstructive azoospermia (NOA.\tInterventions: Microscopical appearance of seminiferous tubules was recorded during TESE surgery. Differing from others, the largest opaque-white in color tubules were cut and removed. When all the tubules have no discriminating appearance, randomized biopsies were obtained. Removed tissue pieces were subjected to mechanical mincing under the stereomicroscope and then enzymatic digestion processes. Using inversion microscope (x32 magnification spermatozoa were searched. Main Outcome Measures: Morphological appearance of seminiferous tubules under optical magnification, spermatozoa recovery rates and histopathological findings were compared.\tRESULTS: In cases of Sertoli cell-only syndrome (SCOS, maturation arrest, hypospermatogenesis and focal spermatogenesis TESE yielded at least one spermatozoon in 37%, 52%, 100% and 63% of the cases, respectively. When all the seminiferous tubules were homogenously swollen, histopathological diagnosis was hypospermatogenesis in 100% of the cases. Homogenously thin and transparent tubules corresponded to SCOS or maturation arrest in 90% and 10% of the cases, respectively. Mature spermatozoa recovery rates were 100% and zero in homogenously-swollen observed and homogenously-thin observed tubules, respectively. CONCLUSIONS: Present data indicate that in cases of all tubules are homogenous in appearance and none of them can be discriminated from others, using microscope has no advantage in selection of the tubuli to be removed, but randomizely selection would also be sufficient. MicroTESE significantly increases the success in NOA cases with seminiferous tubules dispersed heterogeneously.

  4. NOA at the Calaveras Dam Replacement Project (CDRP) - Challenges and Solutions

    Science.gov (United States)

    Erskine, B.

    2012-12-01

    The San Francisco Public Utilities Commission is one year into construction of the Calaveras Dam Replacement Project (CDRP), a new earthen dam east of Sunol designed to withstand an M 7.1 earthquake on the nearby active Calaveras fault. The zoned earthen dam will be constructed primarily of on-site materials, many of which contain NOA. The upstream shell will be composed of Franciscan complex blueschist which contains crocidolite. This material will be blasted and processed at an on-site quarry. The impermeable core of the dam will be constructed of clay-rich alluvium that contains asbestos derived from Franciscan rocks. This material will be excavated from the south end of the reservoir and transported several miles to the dam. Currently, approximately 3 million yards of Franciscan complex material is being excavated and disposed of within permitted on-site engineered landfills. NOA-bearing rocks that include serpentinite, greenschist, blueschist, and eclogite contain variable amounts and assemblages of chrysotile, actinolite, crocidolite, tremolite, and winchite-class amphiboles. All of these are detected in air samples collected within a sophisticated air monitoring array and analyzed by TEM. The CDRP represents the largest construction project involving NOA in the country. As such, applying regulations that were designed for building materials and routine construction sites, and controlling airborne emissions on such a massive scale, is a major challenge requiring innovative solutions. Because construction occurs simultaneously at distinct and distant parts of the site, and the rugged topography of the site induces complex meteorological conditions, it is sometimes difficult to ascertain the driving activity and location of a source that caused a trigger level exceedance at a perimeter monitoring station. One helpful tool is forensic correlation of source material and air test data using speciation of amphiboles. At the CDRP, we are developing the ability to

  5. Coming to terms with our colonial past: Regina di fiori e di perle by ...

    African Journals Online (AJOL)

    Il romanzo Regina di fiori e di perle (2007) di Gabriella Ghermandi presenta due filoni narrativi: quello nel quale vengono raccolti oralmente i racconti dei testimoni degli anni coloniali sotto il fascismo, e quello del bildungsroman, nel quale il personaggio principale, Mahlet, cresce e si rende conto del proprio destino di ...

  6. AlleleCoder: a PERL script for coding codominant polymorphism data for PCA analysis

    Science.gov (United States)

    A useful biological interpretation of diploid heterozygotes is in terms of the dose of the common allele (0, 1 or 2 copies). We have developed a PERL script that converts FASTA files into coded spreadsheets suitable for Principal Component Analysis (PCA). In combination with R and R Commander, two- ...

  7. Good Moments in Gestalt Therapy: A Descriptive Analysis of Two Perls Sessions.

    Science.gov (United States)

    Boulet, Donald; And Others

    1993-01-01

    Analyzed two Gestalt therapy sessions conducted by Fritz Perls using category system for identifying in-session client behaviors valued by Gestalt therapists. Four judges independently rated 210 client statements. Found common pattern of therapeutic movement: initial phase dominated by building block good moments and second phase characterized by…

  8. Multicenter pilot study of radio-chemotherapy as first-line treatment for adults with medulloblastoma (NOA-07)

    DEFF Research Database (Denmark)

    Dagmar, Dagmar; Proescholdt, Martin; Reinert, Christiane

    2018-01-01

    Background: Medulloblastoma in adult patients is rare, with 0.6 cases per million. Prognosis depends on clinical factors and medulloblastoma entity. No prospective data on the feasibility of radio-chemotherapy exist. The German Neuro-Oncology Working Group (NOA) performed a prospective descriptiv...

  9. Learning SAS’s Perl Regular Expression Matching the Easy Way: By Doing

    Science.gov (United States)

    2015-01-12

    Doing 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Paul Genovesi 5d. PROJECT NUMBER 5e. TASK NUMBER 5f...regex_learning_tool allows both beginner and expert to efficiently practice PRX matching by selecting and processing only the match records that the user is interested...perl regular expression and/or source string. The regex_learning_tool allows both beginner and expert to efficiently practice PRX matching by

  10. PeRL: a circum-Arctic Permafrost Region Pond and Lake database

    Science.gov (United States)

    Muster, Sina; Roth, Kurt; Langer, Moritz; Lange, Stephan; Cresto Aleina, Fabio; Bartsch, Annett; Morgenstern, Anne; Grosse, Guido; Jones, Benjamin; Sannel, A. Britta K.; Sjöberg, Ylva; Günther, Frank; Andresen, Christian; Veremeeva, Alexandra; Lindgren, Prajna R.; Bouchard, Frédéric; Lara, Mark J.; Fortier, Daniel; Charbonneau, Simon; Virtanen, Tarmo A.; Hugelius, Gustaf; Palmtag, Juri; Siewert, Matthias B.; Riley, William J.; Koven, Charles D.; Boike, Julia

    2017-06-01

    Ponds and lakes are abundant in Arctic permafrost lowlands. They play an important role in Arctic wetland ecosystems by regulating carbon, water, and energy fluxes and providing freshwater habitats. However, ponds, i.e., waterbodies with surface areas smaller than 1. 0 × 104 m2, have not been inventoried on global and regional scales. The Permafrost Region Pond and Lake (PeRL) database presents the results of a circum-Arctic effort to map ponds and lakes from modern (2002-2013) high-resolution aerial and satellite imagery with a resolution of 5 m or better. The database also includes historical imagery from 1948 to 1965 with a resolution of 6 m or better. PeRL includes 69 maps covering a wide range of environmental conditions from tundra to boreal regions and from continuous to discontinuous permafrost zones. Waterbody maps are linked to regional permafrost landscape maps which provide information on permafrost extent, ground ice volume, geology, and lithology. This paper describes waterbody classification and accuracy, and presents statistics of waterbody distribution for each site. Maps of permafrost landscapes in Alaska, Canada, and Russia are used to extrapolate waterbody statistics from the site level to regional landscape units. PeRL presents pond and lake estimates for a total area of 1. 4 × 106 km2 across the Arctic, about 17 % of the Arctic lowland ( pangaea.de/10.1594/PANGAEA.868349" target="_blank">https://doi.pangaea.de/10.1594/PANGAEA.868349.

  11. PeRL: A circum-Arctic Permafrost Region Pond and Lake database

    Science.gov (United States)

    Muster, Sina; Roth, Kurt; Langer, Moritz; Lange, Stephan; Cresto Aleina, Fabio; Bartsch, Annett; Morgenstern, Anne; Grosse, Guido; Jones, Benjamin; Sannel, A.B.K.; Sjoberg, Ylva; Gunther, Frank; Andresen, Christian; Veremeeva, Alexandra; Lindgren, Prajna R.; Bouchard, Frédéric; Lara, Mark J.; Fortier, Daniel; Charbonneau, Simon; Virtanen, Tarmo A.; Hugelius, Gustaf; Palmtag, J.; Siewert, Matthias B.; Riley, William J.; Koven, Charles; Boike, Julia

    2017-01-01

    Ponds and lakes are abundant in Arctic permafrost lowlands. They play an important role in Arctic wetland ecosystems by regulating carbon, water, and energy fluxes and providing freshwater habitats. However, ponds, i.e., waterbodies with surface areas smaller than 1. 0 × 104 m2, have not been inventoried on global and regional scales. The Permafrost Region Pond and Lake (PeRL) database presents the results of a circum-Arctic effort to map ponds and lakes from modern (2002–2013) high-resolution aerial and satellite imagery with a resolution of 5 m or better. The database also includes historical imagery from 1948 to 1965 with a resolution of 6 m or better. PeRL includes 69 maps covering a wide range of environmental conditions from tundra to boreal regions and from continuous to discontinuous permafrost zones. Waterbody maps are linked to regional permafrost landscape maps which provide information on permafrost extent, ground ice volume, geology, and lithology. This paper describes waterbody classification and accuracy, and presents statistics of waterbody distribution for each site. Maps of permafrost landscapes in Alaska, Canada, and Russia are used to extrapolate waterbody statistics from the site level to regional landscape units. PeRL presents pond and lake estimates for a total area of 1. 4 × 106 km2 across the Arctic, about 17 % of the Arctic lowland ( s.l.) land surface area. PeRL waterbodies with sizes of 1. 0 × 106 m2 down to 1. 0 × 102 m2 contributed up to 21 % to the total water fraction. Waterbody density ranged from 1. 0 × 10 to 9. 4 × 101 km−2. Ponds are the dominant waterbody type by number in all landscapes representing 45–99 % of the total waterbody number. The implementation of PeRL size distributions in land surface models will greatly improve the investigation and projection of surface inundation and carbon fluxes in permafrost lowlands. Waterbody maps, study area

  12. The electronic quenching rates of NO(A2Σ+, v'=0-2)

    International Nuclear Information System (INIS)

    Nee, J.B.; Juan, C.Y.; Hsu, J.Y.; Yang, J.C.; Chen, W.J.

    2004-01-01

    The electronic quenching rates of NO(A 2 Σ + , v ' =0-2) are measured for the gases He, Ar, Xe, N 2 , O 2 , CO 2 , N 2 O, and SF 6 . The variations of the fluorescence intensity were measured for the (0,0), (1,0), and (2,0) bands of the γ band system when the quencher gases were added. The quenching rates were determined by using the Stern-Volmer plots with the known radiative lifetimes of the excited states. The electronic quenching rate constants are fast for the group of gases of O 2 , CO 2 , N 2 O, and SF 6 , whose quenching rate constants are in the order of 10 -10 cm 3 /s. The quenching rate constants are slow for the group of gases including He, Ar, Xe, and N 2 whose rate constants are in the order of 10 -14 cm 3 /s. For the slow group, the quenching rate constants increase rapidly for v ' =2 compared with those of v ' =0 and 1. The charge transfer model and collision complex model are used to understand the quenching mechanism. For the fast group which mainly consists of gases with positive electron affinities, the charge transfer model adequately describes the mechanism. For the slow quenching group, a theoretical background is provided by consider the coupling of initial and final states in the complex potential surfaces

  13. Gestalt Therapy and the Therapeutic Presence of Fritz Perls: An Interview with Claudio Naranjo

    Directory of Open Access Journals (Sweden)

    Iván Ramírez Calderón

    2011-01-01

    Full Text Available As exceptional witness and participant in the origin and development of the Gestalt therapy, Claudio Naranjo considers in this interview the cha- racteristics of this form of therapy, doing so from his work and his personal encounter with the man and the therapeutic figure of Fritz Perls. In the interview the experiential base and the therapeutic change elements are established, along with the therapeutic attitude, and the holistic conception of the person; also, the contrasts among academic psychology, the spiritual dimension of human beings, and the therapist’s intuition in the help rela- tionship are highlighted.

  14. Apellidos y haplogrupos del cromosoma Y en 5 poblaciones del NOA

    Directory of Open Access Journals (Sweden)

    Riccio, M. E.

    2003-01-01

    Full Text Available Se analizaron de forma preliminar muestras de sangre hospitalarias de donantes provenientes de la capital de las provincias de Catamarca (N=62, Salta (N=20, Tucumán (N=11. Las mismas fueron comparadas con datos preexistentes de la provincia de Jujuy (Quebrada de Humahuaca, N=28; San Salvador de Jujuy, N=16. Se estudiaron los linajes paternos, analizando la presencia de la transición C a T para el locus DYS199. Las frecuencias génicas del alelo DYS199 T muestran un gradiente decreciente: Quebrada de Humahuaca (0,64, San Salvador de Jujuy (0,31, Salta (0,25, Tucumán (0,18, y Catamarca (0,08. Las diferencias de las frecuencias sólo fueron significativas entre Catamarca y Salta (P<0,05, y Catamarca con Humahuaca y San Salvador (P<0,001. El apellido y el cromosoma Y son transmitidos por vía paterna. Al analizar la correlación entre ambos, en Catamarca, Salta y Tucumán, en promedio, el 2% de los apellidos americanos coincidieron con el haplogrupo americano, mientras que en Jujuy y Quebrada de Humahuaca lo hicieron en un 34%. De los individuos con haplogrupo amerindio fueron más frecuentes los de apellido aborigen en las poblaciones jujeñas (65 %, y los de apellido europeo en las restantes (83 %. Las diferencias significativas de frecuencia entre Jujuy y el resto de las provincias puede ser el producto de una historia de migraciones y mezcla génica originada a partir de la colonización española del NOA.

  15. Quantitative Determination of Noa (Naturally Occurring Asbestos) in Rocks : Comparison Between Pcom and SEM Analysis

    Science.gov (United States)

    Baietto, Oliviero; Amodeo, Francesco; Giorgis, Ilaria; Vitaliti, Martina

    2017-04-01

    The quantification of NOA (Naturally Occurring Asbestos) in a rock or soil matrix is complex and subject to numerous errors. The purpose of this study is to compare two fundamental methodologies used for the analysis: the first one uses Phase Contrast Optical Microscope (PCOM) while the second one uses Scanning Electron Microscope (SEM). The two methods, although they provide the same result, which is the asbestos mass to total mass ratio, have completely different characteristics and both present pros and cons. The current legislation in Italy involves the use of SEM, DRX, FTIR, PCOM (DM 6/9/94) for the quantification of asbestos in bulk materials and soils and the threshold beyond which the material is considered as hazardous waste is a concentration of asbestos fiber of 1000 mg/kg.(DM 161/2012). The most used technology is the SEM which is the one among these with the better analytical sensitivity.(120mg/Kg DM 6 /9/94) The fundamental differences among the analyses are mainly: - Amount of analyzed sample portion - Representativeness of the sample - Resolution - Analytical precision - Uncertainty of the methodology - Operator errors Due to the problem of quantification of DRX and FTIR (1% DM 6/9/94) our Asbestos Laboratory (DIATI POLITO) since more than twenty years apply the PCOM methodology and in the last years the SEM methodology for quantification of asbestos content. The aim of our research is to compare the results obtained from a PCOM analysis with the results provided by SEM analysis on the base of more than 100 natural samples both from cores (tunnel-boring or explorative-drilling) and from tunnelling excavation . The results obtained show, in most cases, a good correlation between the two techniques. Of particular relevance is the fact that both techniques are reliable for very low quantities of asbestos, even lower than the analytical sensitivity. This work highlights the comparison between the two techniques emphasizing strengths and weaknesses of

  16. Acrylic and metal based Y-branch plastic optical fiber splitter with optical NOA63 polymer waveguide taper region

    Science.gov (United States)

    Ehsan, Abang Annuar; Shaari, Sahbudin; Rahman, Mohd Kamil Abd.

    2011-01-01

    We proposed a simple low-cost acrylic and metal-based Y-branch plastic optical fiber (POF) splitter which utilizes a low cost optical polymer glue NOA63 as the main waveguiding medium at the waveguide taper region. The device is composed of three sections: an input POF waveguide, a middle waveguide taper region and output POF waveguides. A desktop high speed CNC engraver is utilized to produce the mold inserts used for the optical devices. Short POF fibers are inserted into the engraved slots at the input and output ports. UV curable optical polymer glue NOA63 is injected into the waveguide taper region and cured. The assembling is completed when the top plate is positioned to enclose the device structure and connecting screws are secured. Both POF splitters have an average insertion loss of 7.8 dB, coupling ratio of 55: 45 and 57: 43 for the acrylic and metal-based splitters respectively. The devices have excess loss of 4.82 and 4.73 dB for the acrylic and metal-based splitters respectively.

  17. Desgaste por deslizamiento en seco de aceros perlíticos y bainíticos

    Directory of Open Access Journals (Sweden)

    Cristian Camilo Viáfara Arango

    2004-01-01

    Full Text Available El desgaste por deslizamiento tiene una gran influencia sobre el desempeño de los sistemas rueda-riel, en particular, por el deslizamiento de la pestaña de la rueda sobre la parte interna del riel en una pista curva. Dado que el deslizamiento entre la rueda y el riel involucra efectos de adhesión, altos porcentajes de deslizamiento/rodadura afectan fuertemente el desgaste por fatiga de contacto por rodadura, que actúa en las superficies de contacto. En una máquina Pin sobre Disco se llevaron a cabo ensayos de desgaste por deslizamiento para estudiar el comportamiento del acero perlítico AISI 1070 y el bainítico AISI 15B30. La velocidad de deslizamiento fue 1 ms-1 para todas las pruebas y se utilizaron cargas normales de 10, 30 y 50 N. La resistencia al desgaste fue relacionada con la pérdida de masa medida después de las pruebas y las superficies desgastadas, al igual que las partículas removidas, fueron analizadas por medio de los microscopios óptico y electrónico. Se realizaron perfiles de microdureza bajo las superficies de contacto para analizar el efecto del endurecimiento por deformación. El acero perlítico mostró mayor resistencia al desgaste que el acero bainítico, debido al excelente comportamiento de endurecimiento por deformación de la perlita comparado con el de la bainita. En el acero perlítico se observaron regímenes de desgaste oxidativo, mientras que en el bainítico el principal mecanismo de remoción de material fue el adhesivo, llevando a un daño mucho más fuerte en la superficie. De hecho, el régimen de desgaste para las probetas bainíticas fue siempre severo, aún con la menor carga normal aplicada.

  18. Adding EUNIS and VAULT rocket data to the VSO with Modern Perl frameworks

    Science.gov (United States)

    Mansky, Edmund

    2017-08-01

    A new Perl code is described, that uses the modern Object-oriented Moose framework, to add EUNIS and VAULT rocket data to the Virtual Solar Observatory website. The code permits the easy fixing of FITS header fields in the case where some FITS fields that are required are missing from the original data files. The code makes novel use of the Moose extensions “before” and “after” to build in dependencies so that database creation of tables occurs before the loading of data, and that the validation of file-dependent tables occurs after the loading is completed. Also described is the computation and loading of the deferred FITS field CHECKSUM into the database following the loading and validation of the file-dependent tables. The loading of the EUNIS 2006 and 2007 flight data, and the VAULT 2.0 flight data is described in detail as illustrative examples.

  19. HackaMol: An Object-Oriented Modern Perl Library for Molecular Hacking on Multiple Scales.

    Science.gov (United States)

    Riccardi, Demian; Parks, Jerry M; Johs, Alexander; Smith, Jeremy C

    2015-04-27

    HackaMol is an open source, object-oriented toolkit written in Modern Perl that organizes atoms within molecules and provides chemically intuitive attributes and methods. The library consists of two components: HackaMol, the core that contains classes for storing and manipulating molecular information, and HackaMol::X, the extensions that use the core. The core is well-tested, well-documented, and easy to install across computational platforms. The goal of the extensions is to provide a more flexible space for researchers to develop and share new methods. In this application note, we provide a description of the core classes and two extensions: HackaMol::X::Calculator, an abstract calculator that uses code references to generalize interfaces with external programs, and HackaMol::X::Vina, a structured class that provides an interface with the AutoDock Vina docking program.

  20. PERL - European research project on characterization of gaskets for bolted flange connections

    International Nuclear Information System (INIS)

    Kockelmann, H.; Hahn, R.

    2004-01-01

    Great progress was observed in the European standardization in the last years in the field of the design of floating type bolted flange connections. New design rules were developed (EN 1591) which include new definitions of gasket characteristics for the calculation of floating type flanged joints. In addition a new gasket testing standard was drafted (prEN 13555) which assures a comprehensive characterization of gaskets for bolted flanged joints. This draft standard contains some new features which were examined and validated within the European research project PERL (Pressure Equipment - Reduction of Leak Rate). The gasket testing strategy laid down in prEN 13555 is presented in this paper. Some testing results highlighten the measuring procedures and the evaluation of the gasket characteristics. (orig.)

  1. Using Perls Staining to Trace the Iron Uptake Pathway in Leaves of a Prunus Rootstock Treated with Iron Foliar Fertilizers.

    Science.gov (United States)

    Rios, Juan J; Carrasco-Gil, Sandra; Abadía, Anunciación; Abadía, Javier

    2016-01-01

    The aim of this study was to trace the Fe uptake pathway in leaves of Prunus rootstock (GF 677; Prunus dulcis × Prunus persica) plants treated with foliar Fe compounds using the Perls blue method, which detects labile Fe pools. Young expanded leaves of Fe-deficient plants grown in nutrient solution were treated with Fe-compounds using a brush. Iron compounds used were the ferrous salt FeSO4, the ferric salts Fe2(SO4)3 and FeCl3, and the chelate Fe(III)-EDTA, all of them at concentrations of 9 mM Fe. Leaf Fe concentration increases were measured at 30, 60, 90 min, and 24 h, and 70 μm-thick leaf transversal sections were obtained with a vibrating microtome and stained with Perls blue. In vitro results show that the Perls blue method is a good tool to trace the Fe uptake pathway in leaves when using Fe salts, but is not sensitive enough when using synthetic Fe(III)-chelates such as Fe(III)-EDTA and Fe(III)-IDHA. Foliar Fe fertilization increased leaf Fe concentrations with all Fe compounds used, with inorganic Fe salts causing larger leaf Fe concentration increases than Fe(III)-EDTA. Results show that Perls blue stain appeared within 30 min in the stomatal areas, indicating that Fe applied as inorganic salts was taken up rapidly via stomata. In the case of using FeSO4 a progression of the stain was seen with time toward vascular areas in the leaf blade and the central vein, whereas in the case of Fe(III) salts the stain mainly remained in the stomatal areas. Perls stain was never observed in the mesophyll areas, possibly due to the low concentration of labile Fe pools.

  2. Mapping of a gene responsible for dermatitis in NOA (Naruto Research Institute Otsuka Atrichia) mice, an animal model of allergic dermatitis.

    Science.gov (United States)

    Natori, K; Tamari, M; Watanabe, O; Onouchi, Y; Shiomoto, Y; Kubo, S; Nakamura, Y

    1999-01-01

    The NOA (Naruto Research Institute Otsuka Atrichia) mouse is an animal model of allergic or atopic dermatitis, a condition characterized by ulcerative skin lesions with accumulation of mast cells and increased serum IgE. These features of the murine disease closely resemble human atopy and atopic disorders. We performed linkage analysis in NOA back-cross progeny, as a step toward identifying and isolating a gene responsible for the NOA phenotype. We crossed NOA mice with five other murine strains (C57BL/6J, IQI, C3H/HeJ, DBA/2J, and BALB/cByJ) and then bred back-cross animals. Using microsatellite markers, we scanned the entire genomes of 559 N2 offspring from the five parental strains. Linkage analysis revealed a significant association between ulcerative skin lesions and markers on murine chromosome 14. Statistical analysis indicated that the critical region was assigned to the vicinity of D14Mit236 and D14Mit160.

  3. Distinct Expression Profiles and Novel Targets of MicroRNAs in Human Spermatogonia, Pachytene Spermatocytes, and Round Spermatids between OA Patients and NOA Patients

    Directory of Open Access Journals (Sweden)

    Chencheng Yao

    2017-12-01

    Full Text Available Human spermatogenesis includes three main stages, namely, the mitosis of spermatogonia, meiosis of spermatocytes, and spermiogenesis of spermatids, which are precisely regulated by epigenetic and genetic factors. Abnormality of epigenetic and genetic factors can result in aberrant spermatogenesis and eventual male infertility. However, epigenetic regulators in controlling each stage of normal and abnormal human spermatogenesis remain unknown. Here, we have revealed for the first time the distinct microRNA profiles in human spermatogonia, pachytene spermatocytes, and round spermatids between obstructive azoospermia (OA patients and non-obstructive azoospermia (NOA patients. Human spermatogonia, pachytene spermatocytes, and round spermatids from OA patients and NOA patients were isolated using STA-PUT velocity sedimentation and identified by numerous hallmarks for these cells. RNA deep sequencing showed that 396 microRNAs were differentially expressed in human spermatogonia between OA patients and NOA patients and 395 differentially expressed microRNAs were found in human pachytene spermatocytes between OA patients and NOA patients. Moreover, 378 microRNAs were differentially expressed in human round spermatids between OA patients and NOA patients. The differential expression of numerous microRNAs identified by RNA deep sequencing was verified by real-time PCR. Moreover, a number of novel targeting genes for microRNAs were predicted using various kinds of software and further verified by real-time PCR. This study thus sheds novel insights into epigenetic regulation of human normal spermatogenesis and the etiology of azoospermia, and it could offer new targets for molecular therapy to treat male infertility.

  4. BpWrapper: BioPerl-based sequence and tree utilities for rapid prototyping of bioinformatics pipelines.

    Science.gov (United States)

    Hernández, Yözen; Bernstein, Rocky; Pagan, Pedro; Vargas, Levy; McCaig, William; Ramrattan, Girish; Akther, Saymon; Larracuente, Amanda; Di, Lia; Vieira, Filipe G; Qiu, Wei-Gang

    2018-03-02

    Automated bioinformatics workflows are more robust, easier to maintain, and results more reproducible when built with command-line utilities than with custom-coded scripts. Command-line utilities further benefit by relieving bioinformatics developers to learn the use of, or to interact directly with, biological software libraries. There is however a lack of command-line utilities that leverage popular Open Source biological software toolkits such as BioPerl ( http://bioperl.org ) to make many of the well-designed, robust, and routinely used biological classes available for a wider base of end users. Designed as standard utilities for UNIX-family operating systems, BpWrapper makes functionality of some of the most popular BioPerl modules readily accessible on the command line to novice as well as to experienced bioinformatics practitioners. The initial release of BpWrapper includes four utilities with concise command-line user interfaces, bioseq, bioaln, biotree, and biopop, specialized for manipulation of molecular sequences, sequence alignments, phylogenetic trees, and DNA polymorphisms, respectively. Over a hundred methods are currently available as command-line options and new methods are easily incorporated. Performance of BpWrapper utilities lags that of precompiled utilities while equivalent to that of other utilities based on BioPerl. BpWrapper has been tested on BioPerl Release 1.6, Perl versions 5.10.1 to 5.25.10, and operating systems including Apple macOS, Microsoft Windows, and GNU/Linux. Release code is available from the Comprehensive Perl Archive Network (CPAN) at https://metacpan.org/pod/Bio::BPWrapper . Source code is available on GitHub at https://github.com/bioperl/p5-bpwrapper . BpWrapper improves on existing sequence utilities by following the design principles of Unix text utilities such including a concise user interface, extensive command-line options, and standard input/output for serialized operations. Further, dozens of novel methods for

  5. Influencia de la microestructura en el comportamiento en fatiga de aceros perlíticos

    Directory of Open Access Journals (Sweden)

    Toledano, M.

    2004-04-01

    Full Text Available This article accounts the relationship between the microstructure of pearlitic steels (influenced by the cold-drawn manufacturing process and the growing rate of sub critical cracks, produced by a cyclic-constant amplitude load. The microstructural study is performed in two levels: the pearlitic colony (first level and the pearlitic lamellar microstructure (second microstructural level. The analysis of the fatigue behaviour was focused on the region II of the fatigue crack propagation regime, in which the crack growing rate per cicle, da/dN, is controlled by the amplitude of the stress intensity range, as described by Paris law. The enhancement of the fatigue behaviour, in the stable growing zone, is related with the progressive orientation of the pearlitic colonies in the cold drawing direction, showing a linear relation between the intersect parameter of the Paris law (mechanical property and the alignment angle of the microstructure.

    Este artículo pretende poner de manifiesto la influencia que los cambios microestructurales inducidos en un acero hipoeutectoide mediante un proceso de trefilado, tienen sobre la velocidad de crecimiento de fisuras sub-críticas, desarrolladas por solicitación cíclica con amplitud de carga constante. El análisis microestructural ha sido realizado a dos niveles: la colonia perlítica (primer nivel y la microestructura laminar de la perlita (segundo nivel microestructural. El análisis del comportamiento en fatiga se ha centrado en la región II del régimen de propagación de fisuras por fatiga, en donde la velocidad de crecimiento de fisuras, da/dN, está controlada por la amplitud del factor de intensidad de tensiones, K, según queda descrito por la ley de Paris. Los resultados obtenidos muestran que la mejora en el comportamiento en fatiga de los aceros, en la zona de crecimiento estable de la fisura, se relaciona con el alineamiento de las colonias perlíticas en la dirección del trefilado

  6. Clients' narratives in psychotherapy and therapist's theoretical orientation : an exploratory analysis of Gloria's narratives with Rogers, Ellis and Perls

    OpenAIRE

    Moreira, Paulo; Gonçalves, Óscar F.; Matias, Carla

    2011-01-01

    The therapist’s theoretical orientation has been shown to impact the psychotherapy process. However, less is known about the extent to which the therapist’s orientation may impact clients’ narratives. This exploratory study analysed clients’ narrative production in psychoptherapy, when interacting with different therapists. The data consisted of transcripts of Shostrom’s videotaped therapy sessions between the client Gloria and the therapists Carl Rogers, Fritz Perls and Alb...

  7. Simulation of the atmospheric dispersion at local scale in the area of Cogema (la Hague) using PERLE system

    International Nuclear Information System (INIS)

    Sandu, Irina; Lac, Christine

    2003-01-01

    METEO-FRANCE is presently developing a new system named PERLE which permits real time evaluation of atmospheric dispersion at local scale. This system consists in a non-hydrostatic meteorological model at mezo-scale (Meso-NH) and a particular code for the dispersion of the chemically passive pollutants. As a result of several studies performed by DP/SERV/ENV at Meteo-France, two particular codes have been retained for the dispersion module of PERLE: DIFPAR (EDF) and SPRAY (Aria Technologies). In this study, the dispersion at local scale of Kr 85 in the area of the nuclear-wastes reprocessing plant COGEMA (La Hague) has been simulated with the two dispersion models, initialised with the meteorological fields provided by Meso-NH. The simulations concern the most complete sampling campaign of Kr 85 performed in this area on 18th and 19th september 2001. The evaluation the two models performances and of the PERLE system's results for this campaign has been done by using the CTA (Atmospherical Transfer Coefficient) measured values. (authors)

  8. PeRL: a circum-Arctic Permafrost Region Pond and Lake database

    Directory of Open Access Journals (Sweden)

    S. Muster

    2017-06-01

    Full Text Available Ponds and lakes are abundant in Arctic permafrost lowlands. They play an important role in Arctic wetland ecosystems by regulating carbon, water, and energy fluxes and providing freshwater habitats. However, ponds, i.e., waterbodies with surface areas smaller than 1. 0 × 104 m2, have not been inventoried on global and regional scales. The Permafrost Region Pond and Lake (PeRL database presents the results of a circum-Arctic effort to map ponds and lakes from modern (2002–2013 high-resolution aerial and satellite imagery with a resolution of 5 m or better. The database also includes historical imagery from 1948 to 1965 with a resolution of 6 m or better. PeRL includes 69 maps covering a wide range of environmental conditions from tundra to boreal regions and from continuous to discontinuous permafrost zones. Waterbody maps are linked to regional permafrost landscape maps which provide information on permafrost extent, ground ice volume, geology, and lithology. This paper describes waterbody classification and accuracy, and presents statistics of waterbody distribution for each site. Maps of permafrost landscapes in Alaska, Canada, and Russia are used to extrapolate waterbody statistics from the site level to regional landscape units. PeRL presents pond and lake estimates for a total area of 1. 4 × 106 km2 across the Arctic, about 17 % of the Arctic lowland ( <  300 m a.s.l. land surface area. PeRL waterbodies with sizes of 1. 0 × 106 m2 down to 1. 0 × 102 m2 contributed up to 21 % to the total water fraction. Waterbody density ranged from 1. 0 × 10 to 9. 4 × 101 km−2. Ponds are the dominant waterbody type by number in all landscapes representing 45–99 % of the total waterbody number. The implementation of PeRL size distributions in land surface models will greatly improve the investigation and projection of surface inundation and carbon fluxes in permafrost lowlands

  9. NOA36 Protein Contains a Highly Conserved Nucleolar Localization Signal Capable of Directing Functional Proteins to the Nucleolus, in Mammalian Cells

    Science.gov (United States)

    de Melo, Ivan S.; Jimenez-Nuñez, Maria D.; Iglesias, Concepción; Campos-Caro, Antonio; Moreno-Sanchez, David; Ruiz, Felix A.; Bolívar, Jorge

    2013-01-01

    NOA36/ZNF330 is an evolutionarily well-preserved protein present in the nucleolus and mitochondria of mammalian cells. We have previously reported that the pro-apoptotic activity of this protein is mediated by a characteristic cysteine-rich domain. We now demonstrate that the nucleolar localization of NOA36 is due to a highly-conserved nucleolar localization signal (NoLS) present in residues 1–33. This NoLS is a sequence containing three clusters of two or three basic amino acids. We fused the amino terminal of NOA36 to eGFP in order to characterize this putative NoLS. We show that a cluster of three lysine residues at positions 3 to 5 within this sequence is critical for the nucleolar localization. We also demonstrate that the sequence as found in human is capable of directing eGFP to the nucleolus in several mammal, fish and insect cells. Moreover, this NoLS is capable of specifically directing the cytosolic yeast enzyme polyphosphatase to the target of the nucleolus of HeLa cells, wherein its enzymatic activity was detected. This NoLS could therefore serve as a very useful tool as a nucleolar marker and for directing particular proteins to the nucleolus in distant animal species. PMID:23516598

  10. Pastoral Group Counselling at a High Security Prison in Israel: Integrating Pierre Janet's Psychological Analysis with Fritz Perls' Gestalt Therapy.

    Science.gov (United States)

    Brown, Paul; Brown, Marta

    2015-03-01

    This is a report of a short-term, pastoral counselling group conducted with Jewish internees in a high security prison in Israel. It was held as an adjunct to daily secular individual and group counselling and rehabilitation run by the Department of Social Work. Pastoral counselling employed spiritual and psychosocial methodologies to reduce anger, improve prisoner frustration tolerance, and develop a sense of self-efficacy and communal identity. It combined semi-didactic scriptural input with Pierre Janet's personality model, Fritz Perls' gestalt therapy, and analysis of the group process. © The Author(s) 2015 Reprints and permissions:sagepub.co.uk/journalsPermissions.nav.

  11. PERL-2 and LAVR-2 programs for Monte Carlo calculation of reactivity disturbances with trajectory correlation using random numbers

    International Nuclear Information System (INIS)

    Kamaeva, O.B.; Polevoj, V.B.

    1983-01-01

    Realization of BESM-6 computer of a technique is described for calculating a wide class of reactivity disturbances by plotting trajectories in undisturbed and disturbed systems using one sequence of random numbers. The technique was realized on the base of earlier created programs of calculation of widespreed (PERL) and local (LAVR) reactivity disturbances. The efficiency of the technique and programs is demonstrated by calculation of change of effective neutron-multiplication factor when absorber is substituted for fuel element in a BFS-40 critical assembly and by calculation of control drum characteristics

  12. Mutations in circularly permuted GTPase family genes AtNOA1/RIF1/SVR10 and BPG2 suppress var2-mediated leaf variegation in Arabidopsis thaliana.

    Science.gov (United States)

    Qi, Yafei; Zhao, Jun; An, Rui; Zhang, Juan; Liang, Shuang; Shao, Jingxia; Liu, Xiayan; An, Lijun; Yu, Fei

    2016-03-01

    Leaf variegation mutants constitute a unique group of chloroplast development mutants and are ideal genetic materials to dissect the regulation of chloroplast development. We have utilized the Arabidopsis yellow variegated (var2) mutant and genetic suppressor analysis to probe the mechanisms of chloroplast development. Here we report the isolation of a new var2 suppressor locus SUPPRESSOR OF VARIEGATION (SVR10). Genetic mapping and molecular complementation indicated that SVR10 encodes a circularly permuted GTPase that has been reported as Arabidopsis thaliana NITRIC OXIDE ASSOCIATED 1 (AtNOA1) and RESISTANT TO INHIBITION BY FOSMIDOMYCIN 1 (RIF1). Biochemical evidence showed that SVR10/AtNOA1/RIF1 likely localizes to the chloroplast stroma. We further demonstrate that the mutant of a close homologue of SVR10/AtNOA1/RIF1, BRASSINAZOLE INSENSITIVE PALE GREEN 2 (BPG2), can also suppress var2 leaf variegation. Mutants of SVR10 and BPG2 are impaired in photosynthesis and the accumulation of chloroplast proteins. Interestingly, two-dimensional blue native gel analysis showed that mutants of SVR10 and BPG2 display defects in the assembly of thylakoid membrane complexes including reduced levels of major photosynthetic complexes and the abnormal accumulation of a chlorophyll-protein supercomplex containing photosystem I. Taken together, our findings suggest that SVR10 and BPG2 are functionally related with VAR2, likely through their potential roles in regulating chloroplast protein homeostasis, and both SVR10 and BPG2 are required for efficient thylakoid protein complex assembly and photosynthesis.

  13. (NOA), Imo State, Nigeria

    African Journals Online (AJOL)

    PROF. OLIVER OSUAGWA

    2015-06-01

    Jun 1, 2015 ... different locations. This work would eliminate manual method deficiencies such as time wastage, wrong computation, and ... Analysis, Logical Design, Physical Design, Implementation, and Maintenance. The method of data.

  14. Research to Improve the Efficiency of Double Stereo PCR Microfluidic Chip by Passivating the Inner Surface of Steel Capillary with NOA61.

    Science.gov (United States)

    Wu, Jian; Guo, Wei; Wang, Chunyan; Yu, Kuanxin; Ma, Ying; Chen, Tao; Li, Yinghui

    2015-06-01

    In this paper, we report the improvement of PCR microfluidic chip efficiency achieved by coating the inner surface of steel capillary microchannel with a 22-µm film of the ultraviolet-solidified NOA61 using a device invented by us. Our results indicate that with this treatment, the roughness of the inside wall of steel capillary was improved from Ra = 0.921 to Ra = 0.254. The contact angle was decreased from about 95° to 56°, and the surface hydrophobicity was also increased. The flow pressure for performing the real-time PCR in the microfluidic chip with modified surface was reduced by twofold (2.11/1) and that resulted in a substantially increased efficiency of PCR. A modification of the microchannel interior surface improved the quality of the on-chip integrated PCR procedure.

  15. Achieving a Net Zero Energy Retrofit – in a humid, temperate climate – lessons from the University of Hawai’i at Mānoa

    Energy Technology Data Exchange (ETDEWEB)

    Regnier, Cindy [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Harding, Ari [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Robinson, Alastair [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2015-07-01

    The University of Hawai’i at Mānoa (UHM) partnered with the US Department of Energy (DOE) and the Hawai`i Clean Energy Initiative to develop and implement solutions to retrofit exiting buildings to reduce energy consumption by at least 30% as part of DOE’s Commercial Building Partnerships (CBP) Program1. Kuykendall Hall, located on the UHM campus in Honolulu, was the focus of a CBP analysis and design collaboration among the University of Hawai’i, their consultants, and Lawrence Berkeley National Laboratory (LBNL). Kuykendall Hall consists of two 1960s-era wings – a four-story wing containing classrooms, and a seven-story tower containing offices – with a total floor area of approximately 76,000 square feet (ft²).

  16. TREE2FASTA: a flexible Perl script for batch extraction of FASTA sequences from exploratory phylogenetic trees.

    Science.gov (United States)

    Sauvage, Thomas; Plouviez, Sophie; Schmidt, William E; Fredericq, Suzanne

    2018-03-05

    The body of DNA sequence data lacking taxonomically informative sequence headers is rapidly growing in user and public databases (e.g. sequences lacking identification and contaminants). In the context of systematics studies, sorting such sequence data for taxonomic curation and/or molecular diversity characterization (e.g. crypticism) often requires the building of exploratory phylogenetic trees with reference taxa. The subsequent step of segregating DNA sequences of interest based on observed topological relationships can represent a challenging task, especially for large datasets. We have written TREE2FASTA, a Perl script that enables and expedites the sorting of FASTA-formatted sequence data from exploratory phylogenetic trees. TREE2FASTA takes advantage of the interactive, rapid point-and-click color selection and/or annotations of tree leaves in the popular Java tree-viewer FigTree to segregate groups of FASTA sequences of interest to separate files. TREE2FASTA allows for both simple and nested segregation designs to facilitate the simultaneous preparation of multiple data sets that may overlap in sequence content.

  17. The IronChip evaluation package: a package of perl modules for robust analysis of custom microarrays

    Directory of Open Access Journals (Sweden)

    Brazma Alvis

    2010-03-01

    Full Text Available Abstract Background Gene expression studies greatly contribute to our understanding of complex relationships in gene regulatory networks. However, the complexity of array design, production and manipulations are limiting factors, affecting data quality. The use of customized DNA microarrays improves overall data quality in many situations, however, only if for these specifically designed microarrays analysis tools are available. Results The IronChip Evaluation Package (ICEP is a collection of Perl utilities and an easy to use data evaluation pipeline for the analysis of microarray data with a focus on data quality of custom-designed microarrays. The package has been developed for the statistical and bioinformatical analysis of the custom cDNA microarray IronChip but can be easily adapted for other cDNA or oligonucleotide-based designed microarray platforms. ICEP uses decision tree-based algorithms to assign quality flags and performs robust analysis based on chip design properties regarding multiple repetitions, ratio cut-off, background and negative controls. Conclusions ICEP is a stand-alone Windows application to obtain optimal data quality from custom-designed microarrays and is freely available here (see "Additional Files" section and at: http://www.alice-dsl.net/evgeniy.vainshtein/ICEP/

  18. OS02.1 Multicenter pilot study of radio-chemotherapy as first-line treatment for adults with medulloblastoma - the NOA-07 trial

    Science.gov (United States)

    Beier, D.; Proescholdt, M.; Reinert, C.; Hattingen, E.; Seidel, C.; Dirven, L.; Lürding, R.; Pfister, S.; Pietsch, T.; Hau, P.

    2017-01-01

    Abstract Background: Medulloblastoma in adult patients has a low incidence, with 0.6 cases per million. Prognosis depends on clinical factors and medulloblastoma entity. In contrast to children, no prospective data on the feasibility of radio-chemotherapy in adults exists. The German Neuro-Oncology Working Group (NOA) performed a prospective multicenter single-arm Phase II trial to evaluate the feasibility and toxicity of radio-chemotherapy in this population. Methods: The NOA-07 trial combined cranio-spinal irradiation with vincristine, followed by a maximum of eight cycles of cisplatin, lomustine and vincristine. Adverse events, imaging and progression patterns, combined histological and genetic markers, health-related quality of life (HRQoL) and cognition were evaluated prospectively. The primary endpoints were the rate of toxicity-related treatment terminations after four cycles of chemotherapy, and the toxicity profile. Findings: Thirty patients were evaluable. Fifty percent of patients showed classic, and 50% desmoplastic-nodular histology. Sixty-eight percent of patients were genetically classified into the sonic hedgehog (SHH) subgroup without TP53 alterations, 13.6% in wingless (WNT), and 17.7% in Non-WNT/Non-SHH (Group 4). Four cycles of chemotherapy were feasible in the majority of patients (n=21; 70.0%). Leukopenia was the major toxicity, with 79 events of CTC grade 3 and 4 in 17 patients. Polyneuropathy and ototoxicity were the only grade 3 or 4 non-haematological toxicities during the active treatment phase and occurred 12 times in eight patients and one time in one patient, respectively. Events were also calculated per cycle and showed an increase of toxicity over treatment time. Feasibility appeared to be age-dependent, leading to application of four cycles of chemotherapy in 72.7% of patients below age 45 and 62.5% of patients 45 or above. Testing for all eight adjuvant cycles revealed that 45.5% of all patients younger than 45 years completed

  19. Perl's of wisdom

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1991-04-15

    Physics moves fast, and what was once a major discovery quickly becomes bread and butter for a subsequent generation of experiments. Nowhere is this more true that with the Z particle - the electrically neutral carrier of the weak nuclear force. Long expected following the revelation at CERN in 1973 that the weak nuclear force does not necessarily permute electric charge, the Z was discovered by Carlo Rubbia's UA 1 team at CERN's proton - antiproton collider in 1983.

  20. Long-term analysis of the NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with PCV or temozolomide

    Science.gov (United States)

    Wick, Wolfgang; Roth, Patrick; Hartmann, Christian; Hau, Peter; Nakamura, Makoto; Stockhammer, Florian; Sabel, Michael C.; Wick, Antje; Koeppen, Susanne; Ketter, Ralf; Vajkoczy, Peter; Eyupoglu, Ilker; Kalff, Rolf; Pietsch, Torsten; Happold, Caroline; Galldiks, Norbert; Schmidt-Graf, Friederike; Bamberg, Michael; Reifenberger, Guido; Platten, Michael; von Deimling, Andreas; Meisner, Christoph; Wiestler, Benedikt; Weller, Michael

    2016-01-01

    Background Optimal treatment and precise classification for anaplastic glioma are needed. Methods The objective for long-term follow-up of NOA-04 is to optimize the treatment sequence for patients with anaplastic gliomas. Patients were randomized 2:1:1 to receive the standard radiotherapy (RT) (arm A), procarbazine, lomustine and vincristine (PCV) (arm B1), or temozolomide (TMZ) (arm B2). Results Primary endpoint was time-to-treatment-failure (TTF), defined as progression after 2 lines of therapy or any time before if no further therapy was administered. Exploratory analyses examined associations of molecular marker status with TTF, progression-free survival (PFS), and overall survival (OS). At 9.5 (95% CI: 8.6–10.2) years, no difference between arms (A vs B1/B2) was observed: median TTF (4.6 [3.4–5.1] y vs 4.4 [3.3–5.3) y), PFS (2.5 [1.3–3.5] y vs 2.7 [1.9–3.2] y), and OS (8 [5.5–10.3] y vs 6.5 [5.4–8.3] y). Oligodendroglial versus astrocytic histology—but more so the subgroups according to CpG island methylator phenotype (CIMP) and 1p/19q co-deletion status—revealed a strong prognostic value of CIMPpos with (CIMPcodel) versus without 1p/19 co-deletion (CIMPnon-codel) versus CIMPneg. but no differential efficacy of RT versus chemotherapy for any of the endpoints. PFS was better for PCV- than for TMZ-treated patients with CIMPcodel tumors (HR B1 vs B2 0.39 [0.17–0.92], P = .031). In CIMPneg. tumors, hypermethylation of the O6-methyl-guanyl-DNA methyltransferase promoter (MGMT) provided a risk reduction for PFS with chemotherapy. Conclusions There is no differential activity of primary chemotherapy versus RT in any subgroup of anaplastic glioma. Molecular diagnosis is superior to histology. Trial Registration: clinicaltrials.gov Identifier: NCT00717210. PMID:27370396

  1. OS7.7 Feasibility and toxicity of concomitant radiochemotherapy with vincristine in adult patients with medulloblastoma - results from the NOA-07 trial

    Science.gov (United States)

    Seidel, C.; Reimers, C.; Beier, D.; Pietsch, T.; Warmuth-Metz, M.; Bogdahn, U.; Kortmann, R.; Hau, P.

    2016-01-01

    Abstract Introduction: Medulloblastoma is a tumor of the cerebellum that is rare in adults with an incidence of about 0.6 cases per million per year. In children the introduction of chemotherapy with cisplatin, lomustine and vincristine in combination with craniospinal radiotherapy led to a significant improvement of overall survival. In adults, this regimen was never prospectively investigated in a clinical trial. Methods. The NOA-07 trial is a prospective single arm Phase II study to evaluate toxicity of craniospinal irradiation (1.6 Gy/35.2 Gy, posterior fossa boost 1.8 Gy/55.0 Gy) in combination with vincristine (1.5 mg/m2 weekly, ceiling dose 2.0 mg) followed by adjuvant chemotherapy with a maximum 8 of 6-weekly cycles of cisplatin (70 mg/m2, day 1), lomustine (75 mg/m2, day 1) and vincristine (1.5 g/m2, ceiling dose 2.0 mg, day 1, 8, 15) in adults with medulloblastoma. Here, we report on feasibility and toxicity of the concomitant radiochemotherapy. Results. 30 patients with medulloblastoma were recruited in 15 German centers. Radiotherapy was completed in all patients. Treatment interruptions occurred in 3/30 patients (toxicity related: 2, compliance: 1). Leukopenia was the major toxicity with grade 3 and 4 (CTC Version 3.0) occurring in 11 of 30 patients and 1 of 30 patients, respectively. Grade 3 to 4 thrombocytopenia occurred in 1 patient. Grade 3 to 4 infections occurred in 3 patients. Polyneuropathy due to vincristine was the most prevalent adverse event (Grade 1: 5, Grade 2: 4, Grade 3: 5 of 30 patients). Frequent but less severe toxicities involved sickness, dermatitis and alopecia. Conclusion. Concomitant radiochemotherapy with vincristine was feasible in adults with medulloblastoma. Leukopenia and polyneuropathy are major complications, pointing out that polyneuropathy occurs already early in treatment after application of only 1 to 6 doses in a substantial number of patients. Toxicity of the complete treatment protocol including

  2. Long-term analysis of the NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with PCV or temozolomide.

    Science.gov (United States)

    Wick, Wolfgang; Roth, Patrick; Hartmann, Christian; Hau, Peter; Nakamura, Makoto; Stockhammer, Florian; Sabel, Michael C; Wick, Antje; Koeppen, Susanne; Ketter, Ralf; Vajkoczy, Peter; Eyupoglu, Ilker; Kalff, Rolf; Pietsch, Torsten; Happold, Caroline; Galldiks, Norbert; Schmidt-Graf, Friederike; Bamberg, Michael; Reifenberger, Guido; Platten, Michael; von Deimling, Andreas; Meisner, Christoph; Wiestler, Benedikt; Weller, Michael

    2016-11-01

    Optimal treatment and precise classification for anaplastic glioma are needed. The objective for long-term follow-up of NOA-04 is to optimize the treatment sequence for patients with anaplastic gliomas. Patients were randomized 2:1:1 to receive the standard radiotherapy (RT) (arm A), procarbazine, lomustine and vincristine (PCV) (arm B1), or temozolomide (TMZ) (arm B2). Primary endpoint was time-to-treatment-failure (TTF), defined as progression after 2 lines of therapy or any time before if no further therapy was administered. Exploratory analyses examined associations of molecular marker status with TTF, progression-free survival (PFS), and overall survival (OS). At 9.5 (95% CI: 8.6-10.2) years, no difference between arms (A vs B1/B2) was observed: median TTF (4.6 [3.4-5.1] y vs 4.4 [3.3-5.3) y), PFS (2.5 [1.3-3.5] y vs 2.7 [1.9-3.2] y), and OS (8 [5.5-10.3] y vs 6.5 [5.4-8.3] y). Oligodendroglial versus astrocytic histology-but more so the subgroups according to CpG island methylator phenotype (CIMP) and 1p/19q co-deletion status-revealed a strong prognostic value of CIMP pos with (CIMP codel ) versus without 1p/19 co-deletion (CIMP non-codel ) versus CIMP neg . but no differential efficacy of RT versus chemotherapy for any of the endpoints. PFS was better for PCV- than for TMZ-treated patients with CIMP codel tumors (HR B1 vs B2 0.39 [0.17-0.92], P = .031). In CIMP neg . tumors, hypermethylation of the O6-methyl-guanyl-DNA methyltransferase promoter (MGMT) provided a risk reduction for PFS with chemotherapy. There is no differential activity of primary chemotherapy versus RT in any subgroup of anaplastic glioma. Molecular diagnosis is superior to histology. clinicaltrials.gov Identifier: NCT00717210. © The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  3. Avaliação da importância da coloração de Perls na rotina de mielogramas de pacientes com anemia associada a uma ou mais citopenias em sangue periférico Evaluation of the importance of Perls stain in the routine testing of myelograms of patients with anemia associated with one or more peripheral blood cytopenias

    Directory of Open Access Journals (Sweden)

    Nydia S. Bacal

    2005-06-01

    Full Text Available As síndromes mielodisplásicas (SMD são um grupo heterogêneo de doenças malignas das células-tronco hematopoéticas, classificadas segundo a Organização Mundial da Saúde (OMS em: anemia refratária, anemia refratária com sideroblastos em anel, citopenia refratária com displasia de multilinhagens, anemia refratária com excesso de blastos, síndrome mielodisplásica inclassificável e sindrome mielodisplásica associada com anormalidade isolada do cromossomo 5q(del. Na anemia refratária com sideroblastos em anel observam-se hiperplasia e displasia eritróide com presença de 15% ou mais de sideroblastos em anel. Utilizamos neste estudo a coloração de Perls em esfregaços de medula óssea de pacientes com idade superior a 40 anos e que apresentavam uma ou mais citopenias no sangue periférico associada a anemia. Por tratar-se de técnica de manejo fácil e ágil sugerimos seu emprego em esfregaços de aspirado de medula óssea de pacientes que apresentem os achados laboratoriais acima, pois, dentre os casos analisados 18,7% apresentavam mais que 10 grânulos sideróticos circundando a terça parte ou mais do núcleo do precursor eritróide (sideroblasto em anel, sugerindo ao hematologista um possível diagnóstico de Síndrome Mielodisplásica com Sideroblastos em Anel (SMD-ARSA. Importante relatar que a grande maioria destes casos com aumento de sideroblastos em anel não foi encaminhada ao nosso serviço, com suspeita de SMD, e em somente um caso foi solicitada a realização da coloração de Perls.Myelodisplastic syndromes are a heterogeneous group of malignant haematopoietic stem cells. They are classified by the World Health Organization as refractory anemia, refractory anemia with ringed sideroblasts, refractory cytopenia with multilineage displasia, refractory anemia with excess of blast cells, unclassified myelodisplastic syndrome and myelodisplastic syndrome associated with a 5q chromosomal delection. Refractory anemia with

  4. "PERLE bedside-examination-course for candidates in state examination" - Developing a training program for the third part of medical state examination (oral examination with practical skills).

    Science.gov (United States)

    Karthaus, Anne; Schmidt, Anita

    2016-01-01

    In preparation for the state examination, many students have open questions and a need for advice. Tutors of the Skills Lab PERLE-"Praxis ERfahren und Lernen" (experiencing and learning practical skills) have developed a new course concept to provide support and practical assistance for the examinees. The course aims to familiarize the students with the exam situation in order to gain more confidence. This enables the students to experience a confrontation with the specific situation of the exam in a protected environment. Furthermore, soft skills are utilized and trained. Concept of the course: The course was inspired by the OSCE-model (Objective Structured Clinical Examination), an example for case-based learning and controlling. Acquired knowledge can be revised and extended through the case studies. Experienced tutors provide assistance in discipline-specific competencies, and help in organizational issues such as dress code and behaviour. Evaluation of the course: An evaluation was conducted by the attending participants after every course. Based on this assessment, the course is constantly being developed. In March, April and October 2015 six courses, with a total of 84 participants, took place. Overall 76 completed questionnaires (91%) were analysed. Strengths of the course are a good tutor-participants-ratio with 1:4 (1 Tutor provides guidance for 4 participants), the interactivity of the course, and the high flexibility in responding to the group's needs. Weaknesses are the tight schedule, and the currently not yet performed evaluation before and after the course. In terms of "best practise", this article shows an example of how to offer low-cost and low-threshold preparation for the state examination.

  5. Larval migration in PERL chambers as an in vitro model for percutaneous infection stimulates feeding in the canine hookworm Ancylostoma caninum

    Directory of Open Access Journals (Sweden)

    Welz Claudia

    2011-01-01

    Full Text Available Abstract Background Ancylostoma caninum third-stage larvae are the non-feeding infective stage of this parasite and are able to infect potential hosts via different infection routes. Since percutaneous infection is one of the most important routes and skin penetration is the first step into parasitic life, an existing in vitro model for percutaneous migration was modified and evaluated. The main parameter used to evaluate migration was the migration ratio (migrated larvae as a percentage of total number of larvae recovered. Additionally, the skin lag was calculated, expressing the percentage of larvae remaining in the skin and therefore not being recovered. Since initiation of feeding is proposed to be an important step in the transition from free-living to parasitic A. caninum larvae, feeding assays were performed with in vitro percutaneously migrated larvae. Additionally, infective larvae of A. caninum were activated via serum-stimulation and feeding behaviour was analysed and compared between percutaneously migrated and serum-stimulated larvae. Results Maximum skin migration levels of infective larvae were observed at temperatures above 32°C when larvae were placed on the epidermal side of skin for more than 12 hours. The medium beneath the skin had no effect on migration ratio, and no significant difference between the migration ratios through fresh and frozen/thawed skin was observed. Maximum feeding levels of 93.2% were observed for percutaneously migrated larvae after 48 h incubation, whereas serum-stimulated larvae reached the maximum of 91.0% feeding larvae after 24 h. Conclusions The PERL chamber system was optimised and standardised as an in vitro model for percutaneous migration. The larvae recovered after percutaneous migration showed characteristic signs of activation similar to that of serum-stimulated larvae. The observed difference in time course of resumption of feeding indicates that percutaneously migrated larvae are not

  6. How transformational learning promotes caring, consultation and creativity, and ultimately contributes to sustainable development: Lessons from the Partnership for Education and Research about Responsible Living (PERL) network

    Science.gov (United States)

    Thoresen, Victoria Wyszynski

    2017-12-01

    Oases of learning which are transformative and lead to significant behavioural change can be found around the globe. Transformational learning has helped learners not only to understand what they have been taught but also to re-conceptualise and re-apply this understanding to their daily lives. Unfortunately, as many global reports indicate, inspirational transformational learning approaches for sustainable development are rare and have yet to become the norm - despite calls for such approaches by several outstanding educators and organisations. This article examines three learning approaches developed by the network of the Partnership for Education and Research about Responsible Living (PERL). These approaches are structured around core elements of transformative learning for sustainable development, yet focus particularly on the ability to care, consult with others and be creative. They seem to depend on the learners' ability to articulate their perceptions of sustainable development in relation to their own values and to identify how these are actualised in their daily life. Together with other core elements of transformative learning, an almost magical (not precisely measurable) synergy then emerges. The intensity of this synergy appears to be directly related to the individual learner's understanding of the contradictions, interlinkages and interdependencies of modern society. The impact of this synergy seems to be concurrent with the extent to which the learner engages in a continual learning process with those with whom he/she has contact. The findings of this study suggest that mainstreaming transformational learning for sustainable development in ways that release the "magic synergy of creative caring" can result in the emergence of individuals who are willing and able to move from "business as usual" towards more socially just, economically equitable, and environmentally sensitive behaviour.

  7. FunctSNP: an R package to link SNPs to functional knowledge and dbAutoMaker: a suite of Perl scripts to build SNP databases

    Directory of Open Access Journals (Sweden)

    Watson-Haigh Nathan S

    2010-06-01

    Full Text Available Abstract Background Whole genome association studies using highly dense single nucleotide polymorphisms (SNPs are a set of methods to identify DNA markers associated with variation in a particular complex trait of interest. One of the main outcomes from these studies is a subset of statistically significant SNPs. Finding the potential biological functions of such SNPs can be an important step towards further use in human and agricultural populations (e.g., for identifying genes related to susceptibility to complex diseases or genes playing key roles in development or performance. The current challenge is that the information holding the clues to SNP functions is distributed across many different databases. Efficient bioinformatics tools are therefore needed to seamlessly integrate up-to-date functional information on SNPs. Many web services have arisen to meet the challenge but most work only within the framework of human medical research. Although we acknowledge the importance of human research, we identify there is a need for SNP annotation tools for other organisms. Description We introduce an R package called FunctSNP, which is the user interface to custom built species-specific databases. The local relational databases contain SNP data together with functional annotations extracted from online resources. FunctSNP provides a unified bioinformatics resource to link SNPs with functional knowledge (e.g., genes, pathways, ontologies. We also introduce dbAutoMaker, a suite of Perl scripts, which can be scheduled to run periodically to automatically create/update the customised SNP databases. We illustrate the use of FunctSNP with a livestock example, but the approach and software tools presented here can be applied also to human and other organisms. Conclusions Finding the potential functional significance of SNPs is important when further using the outcomes from whole genome association studies. FunctSNP is unique in that it is the only R

  8. Aasta 2003 haagiseturul / Ahto Perling

    Index Scriptorium Estoniae

    Perling, Ahto, 1970-

    2004-01-01

    Ülevaade haagiste tootmisest ja müügist Lääne- ja Ida-Euroopas 2003. aasta andmetel. Diagrammid: Uute haagiste müük 2003; Madelpoolhaagiste müük 2003; Külmikpoolhaagiste müük 2003; Konteinerpoolhaagiste müük 2003

  9. Nutritional Aspects of Six Quinoa (Chenopodium quinoa Willd. Ecotypes from three Geographical Areas of Chile Aspectos Nutricionales de Seis Ecotipos de Quínoa (Chenopodium quinoa Willd. de Tres Zonas Geográficas de Chile

    Directory of Open Access Journals (Sweden)

    Margarita Miranda

    2012-06-01

    Full Text Available This study explored the diversity of the quinoa crop in Chile from a nutritional perspective. Nutritional properties, minerals, vitamins, and saponin content were assessed in seeds of six Chilean quinoa (Chenopodium quinoa Willd. ecotypes grown in three main production areas with distinctive climatic and edaphic conditions: Ancovinto and Cancosa in the North-Altiplano or High Plateau, Cáhuil and Faro in the central coastal area, and Regalona and Villarrica in the south of the country. There were significant differences (P La diversidad en el cultivo de la quinoa (Chenopodium quinoa Willd. de Chile fue explorada desde una perspectiva nutricional. En este contexto las propiedades nutricionales como también los contenidos de minerales, vitaminas y saponina fueron evaluados en las semillas de seis ecotipos chilenos de quínoa, cultivados en las tres principales zonas de producción con condiciones edafoclimáticas distintas: Ancovinto y Cancosa del altiplano del norte, Cáhuil y Faro de la zona costera central y, Regalona y Villarrica en el sur del país. Hubo diferencias significativas (P < 0.05 en todas las propiedades nutricionales de las semillas de todas las zonas. El ecotipo Villarrica tenia el mayor contenido de proteína (16.10 g 100 g-1 MS y de vitamina E y C (4.644 ± 0.240 y 23.065 ± 1.119 mg 100 g-1 MS, respectivamente. El mayor contenido de vitamina B1 (0.648 ± 0.006 mg 100 g-1 MS y B3 (1.569 ± 0.026 mg 100 g-1 MS fue encontrado en el ecotipo Regalona, y el mayor contenido de vitamina B2 (0.081 ± 0.002 mg 100 g-1 MS en el ecotipo Ancovinto. El K fue el mineral más abundante con un valor de 2325.56 mg 100 g-1 MS en el ecotipo Cancosa. El contenido de saponina fluctuó entre 0.84 g 100 g-1 MS en el ecotipo Villarrica y 3.91 g 100 g-1 MS en el ecotipo Cáhuil. Hubo diferencias significativas entre los ecotipos chilenos de quínoa cultivados bajo diferentes condiciones climáticas. No obstante, las semillas de quinoa de cualquier

  10. Établir un corpus oral de questions : L’analyse semi-automatisée avec Praat et Perl à l’exemple de cinq épisodes de Maya l’Abeille

    Directory of Open Access Journals (Sweden)

    Reinhardt Janina

    2016-01-01

    Full Text Available Cette communication donne des directives pour la sélection des textes ainsi que des propositions concernant l’usage des outils Praat et Perl, puis les applique à un exemple. À l’heure actuelle, le traitement par ordinateur devient de plus en plus important pour l’analyse des corpus. Cependant, l’exploitation de données prêtes à l’usage nous fait parfois oublier qu’un corpus doit tout d’abord être composé de manière adéquate. De plus, l’automatisation peut être très utile, mais il est impératif de l’utiliser uniquement pour ce qui est décidable par les ordinateurs. Par conséquent, la contribution de cet article est une annotation manuelle par Praat, joint à l’application d’un script de Perl exécutant la partie automatisable. Cet article a trois objectifs : supporter et améliorer les recherches s’appuyant sur des corpus, développer une méthodologie pour établir et analyser un corpus de questions parlées, et enfin d’exemplifier une telle procédure à l’aide d’un petit corpus, à savoir cinq épisodes de l’émission télévisée Maya l’Abeille. Dans ce dernier, je démontre que les patrons intonatifs ne peuvent pas être associés directement aux structures morphosyntaxiques. De surcroît, les résultats soutiennent l’idée que la variation morphosyntaxique ne peut pas être expliquée par une seule catégorie de variables (intralinguistiques, extralinguistiques ou discursifs mais par l’ensemble des facteurs appartenant à ces trois catégories.

  11. Perl mineral en agua, suelo, forraje y suero sanguíneo de ovinos en Tlaxcala, México/Mineral prole in water, soil, fodder and sheep blood serum in Tlaxcala, México

    Directory of Open Access Journals (Sweden)

    Juan Carlos Muñoz-González

    2017-09-01

    Full Text Available El objetivo fue determinar el perl mineral en muestras de agua, suelo, forraje, alimento concentrado, sales minerales y sangre de 170 ovinos en nueve ranchos del estado de Tlaxcala, México. Los minerales analizados fueron Cu, Fe, Zn, Mn, Ca, Mg, Na, K y P. El modelo estadístico incluyó el efecto del rancho en todas las variables, para la sangre se determinó el efecto de estado siológico. Hubo diferencias (p < 0.05 entre ranchos en las concentraciones de Mg, Na, K y P en el agua. Los suelos de los ranchos tienen concentraciones diferentes (p ≤ 0.05 de Cu, Fe, Zn, Mn, Ca, Mg, Na, K y P. Los contenidos de Zn, Mn, Ca, Na y la relación Ca:P fueron mayores (p < 0.05 en las leguminosas que en las gramíneas. Las concentraciones séricas de Zn, Ca y P fueron mayores (p < 0.05 en los corderos que en las ovejas.

  12. PERLE bedside-examination-course for candidates in state examination” – Developing a training program for the third part of medical state examination (oral examination with practical skills

    Directory of Open Access Journals (Sweden)

    Karthaus, Anne

    2016-08-01

    Full Text Available Introduction: In preparation for the state examination, many students have open questions and a need for advice. Tutors of the Skills Lab PERLE-„Praxis ERfahren und Lernen“ (experiencing and learning practical skills have developed a new course concept to provide support and practical assistance for the examinees.Objectives: The course aims to familiarize the students with the exam situation in order to gain more confidence. This enables the students to experience a confrontation with the specific situation of the exam in a protected environment. Furthermore, soft skills are utilized and trained.Concept of the course: The course was inspired by the OSCE-model (Objective Structured Clinical Examination, an example for case-based learning and controlling. Acquired knowledge can be revised and extended through the case studies. Experienced tutors provide assistance in discipline-specific competencies, and help in organizational issues such as dress code and behaviour.Evaluation of the course: An evaluation was conducted by the attending participants after every course. Based on this assessment, the course is constantly being developed. In March, April and October 2015 six courses, with a total of 84 participants, took place. Overall 76 completed questionnaires (91% were analysed.Discussion: Strengths of the course are a good tutor-participants-ratio with 1:4 (1 Tutor provides guidance for 4 participants, the interactivity of the course, and the high flexibility in responding to the group's needs. Weaknesses are the tight schedule, and the currently not yet performed evaluation before and after the course.Conclusion: In terms of “best practise”, this article shows an example of how to offer low-cost and low-threshold preparation for the state examination.

  13. Auxin influx inhibitors 1-NOA, 2-NOA, and CHPAA interfere with membrane dynamics in tobacco cells

    Czech Academy of Sciences Publication Activity Database

    Laňková, Martina; Smith, R. S.; Pešek, Bedřich; Kubeš, Martin; Zažímalová, Eva; Petrášek, Jan; Hoyerová, Klára

    2010-01-01

    Roč. 61, č. 13 (2010), s. 3589-3598 ISSN 0022-0957 R&D Projects: GA AV ČR KJB600380702; GA MŠk(CZ) LC06034 Grant - others:_(CZ) CZ.2.16/3.1.00/21159 Institutional research plan: CEZ:AV0Z50380511 Keywords : Auxin efflux carrier * auxin influx carrier * auxin transport Subject RIV: EF - Botanics Impact factor: 4.818, year: 2010

  14. Selección e implementación de un modelo para el inicio de la transformación perlítica durante el enfriamiento en los aceros con baja aleación.

    Directory of Open Access Journals (Sweden)

    R. Lobaina Sánchez

    2007-01-01

    Full Text Available Los diagramas Tiempo Temperatura Transformación (TTT de los aceros son de vital importancia para la industria vinculada a la elaboración de los aceros. El desarrollo alcanzado en la obtención de modelos matemáticos de estas curvas ha permitido acercar al ingeniero investigador de la industria y al estudiante, a la comprensión de las variables influyentes en la transformación austenítica, y el impacto que éstas tienen en la modelación de las curvas. En el presente trabajo se valoran diferentes modelos presentados en la literatura consultada. Como resultado, se muestra un modelo para las curvas de inicio de la transformación perlítica, conociendo la composición de los aceros, el tamaño de grano, el sobreenfriamiento y la energía de activación, que son las variables que determinan las diferentes formas que adoptan las curvas. La implementación del modelo seleccionado, ofrece un acercamiento a la posibilidad de crear un aula virtual utilizando una metodología de cálculo, y una herramienta para continuar avanzando en la dirección de perfeccionar y ampliar las posibilidades del resultado presentado.Time-Temperature-Transformation diagrams of steels are of great importance for industry related to steel manufacturing. The development reached in obtaining mathematic models for these curves has allowed the industry research engineer and student to be closer to the comprehension of the influential variables in the austenitic transformation. In this paper different models presented in the consulted literature were valorated. As a result, we show a model for the starting pearlitic transformation curves, depending of the steel composition, the grain size, the undercooling temperature, and the activation energy. The mentioned determine the different shapes the curves. The use of this model gives us the possibility of approaching to the creation of a virtual classroom using the calculation methodology, as well as a tool to improve and widen

  15. Ujuzi (Practical Pearl/Perle Pratique

    Directory of Open Access Journals (Sweden)

    M. Osei-Ampofo

    2015-03-01

    Full Text Available Ujuzi means skills in Swahili and is intended to be a regular feature for colleagues to share practical interventions, innovations and novelties that have proved useful in the management of patients in the prehospital environment or Emergency Centre. You can let Ujuzi know about your practical ideas by emailing practicalpearl@afjem.com.

  16. Three Psychotherapies Examined: Ellis, Rogers, Perls

    Science.gov (United States)

    Stoten, J.; Goos, W.

    1974-01-01

    This study uses Bales' Interaction Process Analysis (I. P. A.) to identify significant process elements in counselling and psychotherapy. For this purpose, the film "Three Approaches to Psychotherapy" was analysed. (Editor)

  17. Noa, a 10-Year-old Composer: A Case Study

    Directory of Open Access Journals (Sweden)

    Michel Hogenes

    2014-12-01

    Full Text Available The present case study aims to contribute to the knowledge of music composition as a meaningful activity in music education. An extensive amount of literature on music composition is available; however, music composition as a regular classroom activity is rarely seen in elementary schools. The effects of closely guided music composition, in which extra attention is paid to the revision of music compositions, on engagement in music education and music achievement in a single subject situation were studied using a three-step-model for music composition based on the cultural-historical activity theory. The authors conclude from this case study that executing music composition activities is possible and potentially accessible for elementary school children. The used music composition model offers classroom teachers and music specialists’ possibilities to teach music composition in elementary schools and make music composition accessible for elementary school children. The current study shows that an intense collaboration between a student, as novice, and her teacher, as more knowledgeable adult, leads to more complex compositions than was seen in classroom situations. The intense collaboration offers the teacher the opportunity to adapt to ideas, needs and interests of the student. Therefore, to offer all children in a classroom situation the assistance they need, working in small groups is suggested.

  18. 33 CFR 160.206 - Information required in an NOA.

    Science.gov (United States)

    2010-07-01

    ... CDC (1) Vessel Information: (i) Name; X X X (ii) Name of the registered owner; X X X (iii) Country of registry; X X X (iv) Call sign; X X X (v) International Maritime Organization (IMO) international number or... (vi) Name of the operator; X X X (vii) Name of the charterer; and X X X (viii) Name of classification...

  19. 'Selección e implementación de un modelo para el inicio de la transformación perlítica durante el enfriamiento en los aceros con baja aleación. R. // Selection and use of a model for the beginning of pearlitic transformation during the cooling in low allo

    Directory of Open Access Journals (Sweden)

    R. Lobaina Sánchez

    2007-01-01

    Full Text Available Los diagramas Tiempo Temperatura Transformación (TTT de los aceros son de vital importancia para la industriavinculada a la elaboración de los aceros. El desarrollo alcanzado en la obtención de modelos matemáticos de estas curvasha permitido acercar al ingeniero investigador de la industria y al estudiante, a la comprensión de las variables influyentesen la transformación austenítica, y el impacto que éstas tienen en la modelación de las curvas. En el presente trabajo sevaloran diferentes modelos presentados en la literatura consultada. Como resultado, se muestra un modelo para las curvasde inicio de la transformación perlítica, conociendo la composición de los aceros, el tamaño de grano, el sobreenfriamientoy la energía de activación, que son las variables que determinan las diferentes formas que adoptan las curvas. Laimplementación del modelo seleccionado, ofrece un acercamiento a la posibilidad de crear un aula virtual utilizando unametodología de cálculo, y una herramienta para continuar avanzando en la dirección de perfeccionar y ampliar lasposibilidades del resultado presentado.Palabras claves: modelos de transformación austenítica, diagramas de transformación isotérmica, diagramasTTT.____________________________________________________________________________Abstract:Time-Temperature-Transformation diagrams of steels are of great importance for industry related to steel manufacturing.The development reached in obtaining mathematic models for these curves has allowed the industry research engineer andstudent to be closer to the comprehension of the influential variables in the austenitic transformation. In this paper differentmodels presented in the consulted literature were valorated. As a result, we show a model for the starting pearlitictransformation curves, depending of the steel composition, the grain size, the undercooling temperature, and the activationenergy. The mentioned determine the different shapes the

  20. Film "Bushizmõ" : lutshije perlõ presidenta

    Index Scriptorium Estoniae

    2004-01-01

    Elisabeth Reederi dokumentaalfilm USA presidendi Georg W. Bushi parimatest ütlustest "Bushisms". Lisaks semiootiku ja kirjaniku U. Eco poolt kogutud lauseid: "Pisatel Umberto Eko sobral znamenitõje võskazõvanija Busha"

  1. Depósito fiscal en Salta Capital para productos agrícolas del NOA

    OpenAIRE

    Balestrini González, Agustín

    2016-01-01

    261 p. il. La siguiente tesis busca describir cuales son los lineamientos o reglamentaciones legales que delimitan el funcionamiento de un Depósito Fiscal, como herramienta de control del órgano fiscalizador Nacional de las operaciones internacionales, la Dirección General de Aduana, que funciona dentro de la órbita de la Administración Federal de Ingresos Públicos. También se busca describir el contexto productivo en el cual podría ejecutarse este depósito y por lo tanto, se incluyó...

  2. Altered gravity causes the changes in the proteins NoA100 in plant cell nucleoli

    Science.gov (United States)

    Sobol, Margarita A.; Gonzalez-Camacho, Fernando; Kordyum, Elizabeth L.; Medina, Francisco Javier

    2005-08-01

    A nucleolar protein homologous to the mammalian nucleolin and to the onion nucleolin-like protein NopA100 was detected in nuclear soluble protein fraction from Lepidium sativum root meristematic cells, using the specific silver staining method and the cross-reaction with the anti-NopA100 antibody. In 2D Western blots of soluble nuclear fraction, NopA100 was revealed as a smear extending through a certain range of pI. In extracts obtained from seedlings grown under clinorotation, the extension of the pI range was shorter than in the stationary control indicating a lower phosphorylation of the protein. This suggests that altered gravity causes a decrease in the rate of nucleolar activity.

  3. Estimating NOA Health Risks from Selected Construction Activities at the Calaveras Dam Replacement Project (CDRP)

    Science.gov (United States)

    Hernandez, D. W.

    2012-12-01

    The CDRP is a major construction project involving up to 400 workers using heavy earth moving equipment, blasting, drilling, rock crushing, and other techniques designed to move 7 million yards of earth. Much of this material is composed of serpentinite, blueschist, and other rocks that contain chrysotile, crocidolite, actinolite, tremolite, and Libby-class amphiboles. To date, over 1,000 personal, work area, and emission inventory related samples have been collected and analyzed by NIOSH 7400, NIOSH 7402, and CARB-AHERA methodology. Data indicate that various CDRP construction activities have the potential to generate significant mineral fibers and structures that could represent elevated on site and off site health risks. This presentation will review the Contractors air monitoring program for this major project, followed by a discussion of predictive methods to evaluate potential onsite and offsite risks. Ultimately, the data are used for planning control strategies designed to achieve a Project Action Level of 0.01 f/cc (one tenth the Cal/OSHA PEL) and risk-based offsite target levels.

  4. 78 FR 77662 - Notice of Availability (NOA) for General Purpose Warehouse and Information Technology Center...

    Science.gov (United States)

    2013-12-24

    ...,500 square feet and would include a 360,000 square feet active bulk warehouse and a 5,500 square feet... parking lot (approximately 295,000 square feet) and new laydown area (approximately 240,000 square feet.... The laydown area would be constructed in an unimproved, irregularly shaped open lot that is...

  5. Web-based biobank system infrastructure monitoring using Python, Perl, and PHP.

    Science.gov (United States)

    Norling, Martin; Kihara, Absolomon; Kemp, Steve

    2013-12-01

    The establishment and maintenance of biobanks is only as worthwhile as the security and logging of the biobank contents. We have designed a monitoring system that continuously measures temperature and gas content, records the movement of samples in and out of the biobank, and also records the opening and closing of the freezers-storing the results and images in a database. We have also incorporated an early warning feature that sends out alerts, via SMS and email, to responsible persons if any measurement is recorded outside the acceptable limits, guaranteeing the integrity of biobanked samples, as well as reagents used in sample analysis. A surveillance system like this increases the value for any biobank as the initial investment is small and the value of having trustworthy samples for future research is high.

  6. Gestalt Therapy: Student Perceptions of Fritz Perls in "Three Approaches to Psychotherapy"

    Science.gov (United States)

    Reilly, Joe; Jacobus, Veronica

    2009-01-01

    The "Three Approaches to Psychotherapy" ("TAP") videotape series introduces students to three major schools of psychotherapy: client-centered therapy, Gestalt therapy, and rational-emotive therapy. A sample of undergraduate students viewed the "TAP" series. The students were surveyed about their observations of…

  7. coming to terms with our colonial past: regina di fiori e di perle by ...

    African Journals Online (AJOL)

    User

    perceptions, the nature of collective memory is a great deal more complex: Personal processes of the .... learnt and the personal identities formulated by the experience of the colonized in their forward looking .... become more willed and desperate as she fights off the sense of fear and confusion at the insistent voices that ...

  8. Epidemiología de los nematodes gastrointestinales en caprinos lecheros en los valles templados del NOA, Argentina

    Directory of Open Access Journals (Sweden)

    SUAREZ, V.H.

    2013-08-01

    Full Text Available Con el fin de estudiar la epidemiología y los efectos de los nematodes gastrointestinales (NGI sobre cabras en ordeño en predios bajo riego en el Valle de Lerma (Salta, se monitoreó la infestación parasitaria en 41 cabras naturalmente infestadas por NGI, desde el 4 de octubre de 2010 hasta el 26 de mayo de 2011. Se evaluaron dos grupos de cabras en ordeño: PJ (n=17 paridas en junio y PS (n=24 paridas en septiembre. Sólo se desparasitaron de urgencia aquellos animales que superaran los 3000 de hpg o y que presentaran signos de parasitosis.

  9. 76 FR 19510 - Notice of Availability (NOA) of the Models For Plant-Specific Adoption of Technical...

    Science.gov (United States)

    2011-04-07

    ... the addition of a Note to prohibit the use of the provisions of Limiting Condition for Operation 3.0.4... in the Federal Register on May 4, 2005 (70 FR 23238). Federal Rulemaking Web site: Supporting...

  10. 78 FR 78943 - Notice of Availability (NOA) of an Environmental Assessment (EA) for the Temporary Storage of...

    Science.gov (United States)

    2013-12-27

    ... Defense Supply Center Richmond, Virginia AGENCY: Defense Logistics Agency, DoD. ACTION: Notice of... at Defense Supply Center Richmond, Virginia. SUMMARY: The Defense Logistics Agency (DLA) announces... Engelberger at (703) 767-0705 during normal business hours Monday through Friday, from 8:00 a.m. to 4:30 p.m...

  11. L'embouteillage stérile a froid des vins tranquilles, perlés et mousseux

    Directory of Open Access Journals (Sweden)

    H. MULLER-SPATH

    1971-12-01

    Les considérations qui vont suivre se rapportent principalement à l'embouteillage stérile à froid après filtration sur plaques stérilisantes éliminant totalement les levures et les bactéries susceptibles de provoquer l'altération du vin en bouteille.

  12. Efectos del cambio climático sobre especies de plantas vasculares del sur de los Andes Centrales: un estudio en el noroeste de Argentina (NOA)

    OpenAIRE

    Godoy Bürki, Ana Carolina

    2017-01-01

    La región de los Andes Tropicales es considerada como una región muy vulnerable al cambio climático porque presenta una alta diversidad y endemismo y porque posee una gran variabilidad altitudinal. Si bien se ha efectuado un gran número de predicciones sobre los cambios que ocurrirán en el clima, pocos estudios evaluaron el impacto que éste tendrá sobre las distribuciones de las especies. En este estudio se estima el efecto del cambio climático sobre la distribución y la conservación de espec...

  13. Expression analysis of MND1/GAJ, SPATA22, GAPDHS and ACR genes in testicular biopsies from non-obstructive azoospermia (NOA) patients

    Czech Academy of Sciences Publication Activity Database

    Dorosh, Andriy; Teplá, O.; Žatecká, Eva; Děd, Lukáš; Kočí, K.; Pěknicová, Jana

    2013-01-01

    Roč. 11, č. 42 (2013) ISSN 1477-7827 R&D Projects: GA ČR(CZ) GAP503/12/1834 Institutional research plan: CEZ:AV0Z50520701 Keywords : Non-obstructive azoospermia * Human test es * Biopsy * Spermatogenesis * gene expression * ICSI Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.409, year: 2013

  14. Presencia de Diaphorina citri (Hemiptera: Psyllidae en el Noroeste Argentino (NOA Record of Diaphorina citri (Hemiptera: Psyllidae in North West Argentina

    Directory of Open Access Journals (Sweden)

    Lucrecia Augier

    2006-12-01

    Full Text Available Se amplía la distribución de Diaphorina citri Kuwayama (Hemiptera: Psyllidae para el Noroeste Argentino.The distribution of Diaphorina citri Kuwayama (Hemiptera: Psyllidae is expanded to North West Argentina.

  15. Investigation report on promotion of geothermal development. No. A-4, Mt. Kunbetsu area; Chinetsu kaihatsu sokushin chosa hokokusho. No.A-4 Kunbetsudake chiiki

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    This paper summarizes the results of investigations in the Mt. Kunbetsu area out of the investigations on promotion of geothermal development having been performed during the period from 1998 to 1999. The investigated area is an area located in the eastern Hokkaido with an area of about 300 km{sup 2}. The wide area investigation has discussed possibilities of existence of geothermal resources mainly from existence of high-temperature anomalies. The investigation has performed the following activities: fluid geochemical investigations on ten spring water sources, three spring gas sources, and five surface water points; gravity exploration at 153 measuring points; electromagnetic exploration at 52 measuring points; excavation of two heat flow rate wells (to depths of 997m and 995m), temperature logging, core cuttings tests, thermal hot water survey; other fluid inclusions tests, rock alteration age measurement; and temperature logging at Ryuun Shiretoko Spa. As a result of the investigations, it was estimated that, as the geothermal system model, the heat source is assumed to exist at a great depth below Mt. Kaibetsu; the spring water and the mineral spring water show diverse spring qualities because of mixing of meteoric water with fossil sea water; the fossil sea water and the meteoric water have been heated by thermal conduction; and the high-temperature zone is not spread to the positions of the investigation wells. (NEDO)

  16. Effet de l'urée et du NPK 15-15-15 perlés et super granulés sur la ...

    African Journals Online (AJOL)

    SARAH

    31 mai 2014 ... Objectifs : La présente étude réalisée sur les sites rizicoles de Koussin et de ... pour une meilleure production des variétés améliorées de riz car ils augmentent substantiellement les ...... Nitrogen deep-placement technologies.

  17. How Transformational Learning Promotes Caring, Consultation and Creativity, and Ultimately Contributes to Sustainable Development: Lessons from the Partnership for Education and Research about Responsible Living (PERL) Network

    Science.gov (United States)

    Thoresen, Victoria Wyszynski

    2017-01-01

    Oases of learning which are transformative and lead to significant behavioural change can be found around the globe. Transformational learning has helped learners not only to understand what they have been taught but also to re-conceptualise and re-apply this understanding to their daily lives. Unfortunately, as many global reports indicate,…

  18. An introduction to language processing with Perl and Prolog an outline of theories, implementation, and application with special consideration of English, French and German

    CERN Document Server

    Nugues, Pierre M

    2005-01-01

    The areas of natural language processing and computational linguistics have continued to grow in recent years, driven by the demand to automatically process text and spoken data. With the processing power and techniques now available, research is scaling up from lab prototypes to real-world, proven applications. This book teaches the principles of natural language processing, first covering linguistics issues such as encoding, entropy, and annotation schemes; defining words, tokens and parts of speech; and morphology. It then details the language-processing functions involved, including part-o

  19. Efecto de la desestabilización de la cementita sobre el desarrollo de altos niveles de resistencia mecánica en aceros perlíticos

    Directory of Open Access Journals (Sweden)

    Mykhaylo Romanyuk

    2016-01-01

    Full Text Available Se estudió la deformación en aceros de alto contenido de carbono trefilados en frío, sobre el comportamiento mecánico y de fractura. La deformación promueve fenómenos de disolución de la cementita en la perlita, alcanzando alta resistencia y ductilidad, lo que permite aplicarlos en usos críticos como cables de grúas. Para estudiar el comportamiento mecánico y a la fractura, se estudian muestras de dos alambres sometidas a torsión hasta rotura. Estos presentan distinto comportamiento: uno sufrió fractura plana (normal y otro fractura delaminada. Se efectúa un estudio estructural mediante microscopía óptica y electrónica de barrido. Los resultados obtenidos muestran la presencia del fenómeno de rizado (curling. Además, se realizan ensayos de análisis térmico diferencial y simulación termodinámica aplicando Fact Sage, para analizar la estabilidad de carburos. Se corroboró la precipitación de carburos épsilon que ocurre por difusión de carbono en la interfaz ferrita-perlita, justificando el incremento de la resistencia mecánica.

  20. Filmiauhinnad ja tänavamuusikute auhinnad jagatud / Karol Kallas

    Index Scriptorium Estoniae

    Kallas, Karol, 1972-

    2007-01-01

    Pärnu 21. dokumentaal- ja antropoloogiafilmide festivali auhindadest. Tänavamuusikute võistumängimise võitsid Pillipiigad Tahkurannast, festivali peaauhinna sai poolarežissöör Wojciech Kasperski filmiga "Seemned", Eesti Rahva Auhinna sai Iisraeli režissöör Yoram Honig filmiga "Esimene koolitund rahus". Lisatud auhinnatud filmide nimekiri

  1. Diversidad de plantas vasculares en zonas áridas del Noroeste de Argentina (NOA): patrones de distribución, prioridades de conservación y cambio climático

    OpenAIRE

    Godoy-Bürki, Ana Carolina

    2015-01-01

    Globalmente, los drylands abarcan más del 41.3% de la superficie de la tierra y son habitados por más de dos billones de personas que dependen de sus servicios ecológicos y culturales. Se denomina drylands a todas aquellas tierras en donde el promedio de precipitaciones es menor a las pérdidas potenciales de humedad que ocurren a través de la evaporación y la transpiración. Dentro de estas tierras, se incluye a las regiones hiper áridas, áridas, semiáridas y sub-húmedas secas. Estas regiones,...

  2. FY 1998 geothermal development promotion survey. Report on the environmental effect survey (No. A-4 Kunbetsu-dake area); 1998 nendo chinetsu kaihatsu sokushin chosa. Kankyo eikyo chosa hokokusho (No.A-4 Kunbetsudake chiiki)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-09-30

    Of the FY 1998 geothermal development promotion survey, the primary environmental effect survey in the Kunbetsu-dake area was conducted, and the results were arranged. In the well drilling survey, etc., the survey was made aiming at extracting areas to be preserved from an environmental aspect. The results of the survey were summarized as follows: As to the mammalia, 12 families 46 species were confirmed in the area surveyed and the periphery by literature survey. Out of them, the noticeable species which are considered important from an academic viewpoint are 10 families 19 species. As to the aves, 55 families 340 species were confirmed, of which 29 families 79 species are noticeable species. About the amphibia/reptilia, 3 families 3 species in the amphibia and 4 families 6 species in the reptilia were confirmed by literature and hearing survey. The noticeable species is 1 family 1 species in the amphilia. Concerning the terrestrial insecta, 135 families 873 species were confirmed, and the noticeable species is 11 families 20 species. As to the flora, 115 families 1055 species were confirmed, and the noticeable species is 46 families 126 species. Relating to the living vegetation, the one higher than 9 in nature reserves shows a substantial rate, and the periphery of Kaibetsu-dake is designated as the specified flora colony. (NEDO)

  3. Fiscal 1998 report on data processing for geothermal energy development enhancement. No. A-4 Mount Kumbetsu area (primary data processing); 1998 nendo chinetsu kaihatsu sokushin chosa data shori hokokusho. No.A-4. Kunbetsu chiiki (dai 1 ji)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-09-01

    This is part of the state-operated 'geothermal energy development enhancement' project, under which a comprehensive analysis is conducted into the results of a survey of geothermal resources in existence in the Mount Kumbetsu area. The local geothermal structure is examined, and the Kumbetsu hot spring area, the Uebetsu river middle reach area, and the Unabetsu hot spring area are extracted as promising high-temperature supply areas. The Kumbetsu hot spring area and the Uebetsu river middle reach area lie on a heave positioned west of the Mount Musa/Mount Shitabanupuri fault. There is a distinguished bending in the zone of discontinuous resistivity, and, when geology is considered, it is inferred that there exists a geothermal fluid field formed by the Mount Musa/Mount Shitabanupuri fault running NNW-SSW and a fracture zone that runs across the fault. The two areas are located at spots where gravity gradient is sharp. It is concluded that, with the alteration zone, temperature distribution, etc., also taken into account, the Kumbetsu hot spring area is the more promising as a source of geothermal energy. The water of the Kumbetsu hot spring is of the Cl-SO{sub 4} type, 64.5 degrees C hot and neutral, and arises from the depth where water of meteoric origin is heated by heat conduction. The heat source is supposedly the magma reservoir whose eruption once formed Mount Unabetsu etc. (NEDO)

  4. FY 1999 report on the data processing of the geothermal development promotion survey. No. A-4 Kunbetsudake area (Secondary); 1999 nendo chinetsu kaihatsu sokushin chosa data shori hokokusho. No.A-4 Kunbetsudake chiiki (dai 2 ji)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-10-01

    This survey studies possibilities of geothermal resource existence by checking the presence of high temperature anomaly by a wide-area survey with the aim of extracting the area for Survey B and Survey C to be conducted. The area for survey is an area of approximately 300km{sup 2} including Shibetsu town, Shibetsu county, and Rausu town, Menashi county, which are located east of Hokkaido. Conceptual models of the geothermal system in this area which are thought of from the results of the survey are as follows. It is assumed that heat source exists deeply in Unabetsudake (Mt. Unabetsu). From the fact that the K-Ar method age of the ejecta is 0.5Ma and the TL method age of the rate. (NEDO)ch the position of drilling of the well for survey of heeffective as heat source. It is thought that the water of hot spring/mineral spring came to indicate various spring qualities by mixture of meteoric water and fossil seawater at various ratios. The fossil seawater and old meteoric water are being heated by thermal conduction. The mixture with the original water of Kawakita hot spa is recognized in Shibetsu Kanayama hot spa. It is assumed that the high temperature area exists mostly in Unabetsudake, but the spread does not reach the position of drilling of the well for survey of heat flow rate. (NEDO)

  5. Fiscal 1998 research report on promotion of geothermal development. Environment impact research report (No. A-4 Kunbetsu-Dake area); 1998 nendo chinetsu kaihatsu sokushin chosa. Kankyo eikyo chosa hokokusho (No.A-4 Kunbetsu chiiki)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-06-01

    For extracting the areas to be conserved from the viewpoint of environment for the research on geothermal well drilling, the environment impact research was made on the protection and regulation states of animals and plants in Kunbetsu-Dake area. 46 species in 12 families of mammals were confirmed in/around the area by document survey, and among them 19 species in 10 families of mammals were important academically. 340 species in 55 families of birds were confirmed, and among them 79 species in 29 families of birds were important academically. 3 species in 3 families of amphibians, and 6 species in 4 families of reptiles were confirmed, and among them 1 species of amphibian was important. 873 species in 135 families of land insects were confirmed, and among them 20 species in 11 families were important. 1055 species in 115 families of plants were confirmed, and among them 126 species in 46 families were important. Most of vegetation was 9 or more in degree of naturalness. The peripheral area of Kaibetsu-Dake is the plant colony area specified by the 2nd basic survey on natural environmental conservation (Environment Agency). (NEDO)

  6. An Adaptive Tabu Search Heuristic for the Location Routing Pickup and Delivery Problem with Time Windows with a Theater Distribution Application

    Science.gov (United States)

    2006-08-01

    including approximations of delivery costs. The solution of a sub-problem provides input for another sub-problem. Perl (1983) and Perl and Daskin (1985...developed in this section represents a modification and combination of both the three-layer location routing formulation of Perl and Daskin (1985) and the...1985) LRP formulation to create the LPDPTW. 4.2.1 Generalization of the LRP Perl and Daskin (1985) utilize a fixed charge location problem as the

  7. Terrorism: A Selected Bibliography

    Science.gov (United States)

    2009-12-01

    HV6430 .B55T36 2006) Schweitzer , Yoram. Female Suicide Bombers: Dying for Equality? Tel Aviv: Tel Aviv University, Jaffee Center for Strategic Studies...Mauroni, Albert J. "The Future of Chemical, Biological, Radiological, and Nuclear Defense." Joint Force Quarterly, no. 44 (1st Quarter 2007): 74-78...http://www.ndu.edu/inss/Press/ jfq_pages/editions/i44/24.pdf Mauroni, Albert J. "The New Threat of Unconventional Warfare." Joint Force Quarterly, no

  8. A Comprehensive Theory of Algorithms for Wireless Networks and Mobile Systems

    Science.gov (United States)

    2016-06-08

    pages 109-118, July 2015. [3] Magnus Halldorsson, Stephan Holzer and Nancy Lynch. A Local Broadcast Layer for the SINR Network Model. ACM Symposium on...publication, 2014. [9] Magnus Halldorsson, Stephan Holzer, Pradipta Mitra and Roger Wattenhofer. The Power of Oblivious Wireless Power. Submitted for...David Peleg. Nonuniform SINR+Voronoi Diagrams are Effectively Uniform. In Yoram Moses, editor, Distributed Computing: 29th International Symposium

  9. Israel and an Emerging World Order

    Science.gov (United States)

    2014-12-01

    back-together 74 Gallia Lindenstrauss and Yaniv Avraham, “Is Turkey Returning to the ‘Zero Problems’ Policy?” INSS Insight, no. 503 (December 30...Quiet Transformations.” 123 Yoram Evron, “Chinese Investments in Israel: Opportunity or National Threat?” INSS Insight, no. 538 (April 8, 2014): 1...Israel: Opportunity or National Threat?” INSS Insight, no. 538 (April 8, 2014). ______. “Chinese Involvement in the Middle East: The Libyan and Syrian

  10. GPSR: A Resource for Genomics Proteomics and Systems Biology

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. GPSR: A Resource for Genomics Proteomics and Systems Biology. Small programs as building unit. Why PERL? Why not BioPerl? Why not PERL modules? Advantage of independent programs. Language independent; Can be run independently.

  11. Couples with non-obstructive azoospermia are interested in future treatments with artificial gametes

    NARCIS (Netherlands)

    Hendriks, S.; Hessel, M.; Mochtar, M. H.; Meissner, A.; van der Veen, F.; Repping, S.; Dancet, E. A. F.

    2016-01-01

    Would couples diagnosed with non-obstructive azoospermia (NOA) consider two future treatments with artificial gametes (AGs) as alternatives for testicular sperm extraction followed by ICSI (TESE-ICSI)? Most couples with NOA (89%) would opt for treatment with AGs before attempting TESE-ICSI and/or

  12. Clinical outcomes and development of children born to couples with obstructive and nonobstructive azoospermia undergoing testicular sperm extraction-intracytoplasmic sperm injection: A comparative study

    Directory of Open Access Journals (Sweden)

    Yi-Ru Tsai

    2015-04-01

    Conclusion: In our study, there were no differences in the fertility rate and clinic pregnancy rate between the OA and NOA groups using TESE-ICSI. Also, the clinical outcomes and development of children were similar between the OA and the NOA groups using TESE-ICSI.

  13. Survey on geothermal development promotion in fiscal 1998. Electromagnetic exploration (simplified MT method) (Separate data (No. A-4 for the Mt. Kunbetsu area)); 1998 nendo chinetsu kaihatsu sokushin chosa. Denji tansa (MT kan'iho) bessatsu shiryo (No.A-4 Kunbetsu chiiki)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    This paper summarizes the result of electromagnetic exploration in the No. A-4 Mt. Kunbetsu area as a separate data for the geothermal development promotion survey. The orders are as follows: in the apparent specific resistance and phase curves, TE mode, TM mode, invariant mode; in the MT parameters, tipper magnitude, tipper strike, impedance rotation, skewness, impedance polar diagram; in the one-dimensional analysis result (TE mode), specific resistance model, measurement/analysis {rho}a-F diagram; in the one-dimensional analysis result (TM mode), specific resistance model, measurement/analysis {rho}a-F diagram; inthe one-dimensional analysis result (invariant mode), specific resistance model, measurement/analysis {rho}a-F diagram; in the measurement value list, tipper magnitude, tipper phase, tipper strike, skewness; and in the value list for the one-dimensional analysis result, TE mode, TM mode, invariant mode and the value list for the two-dimensional analysis result. (NEDO)

  14. Příběh vzácného motýla, který se stal na Šumavě obyčejným aneb co k životu potřebuje perleťovec mokřadní

    Czech Academy of Sciences Publication Activity Database

    Slámová, Irena; Vrba, Pavel; Konvička, Martin

    2012-01-01

    Roč. 2012, - (2012), s. 16-17 ISSN 0862-5166 R&D Projects: GA ČR GAP505/10/2248; GA ČR GAP505/10/2167; GA MŠk LC06073 Grant - others:Grantová agentura Jihočeské univerzity(CZ) GA JU 135/2010/P; Grantová agentura Jihočeské univerzity(CZ) 144/2010/P Institutional support: RVO:60077344 Keywords : Proclossiana eunomia

  15. R6 FIFRA e-Notice of Arrival

    Data.gov (United States)

    U.S. Environmental Protection Agency — This database processes approximately 3,000 Notice of Arrival (NOA) reporting forms from importers and exporters of pesticide products. This is an electronic version...

  16. Exposure to Sumas Mountain chrysotile induces similar gene expression changes as Libby Amphibole but has greater effect on long-term pathology and lung function

    Science.gov (United States)

    This study was designed to provide understanding of the toxicity of naturally occurring asbestos (NOA) including Libby amphibole (LA), Sumas Mountain chrysotile (SM), El Dorado Hills tremolite (ED) and Ontario ferroactinolite cleavage fragments (ON). Rat-respirable fractions (aer...

  17. Communicating with the public about the risks of naturally occurring asbestos

    Directory of Open Access Journals (Sweden)

    Claire Hooker

    2017-12-01

    Full Text Available Objectives: To explore the application of evidence based risk communication to community messaging about naturally occurring asbestos (NOA. Type of program or service: Risk communication education about NOA. Methods: We apply principles and determinants of risk communication to the topic of NOA. Results: We emphasise the importance of erring on the side of transparency and trust, even when officials may be concerned about inadvertently heightening needless public concern. We offer a range of practical suggestions for how to lower public concern and outrage relating to the issue of NOA when it arises in local contexts. Lessons learnt: Public concern and outrage can be reduced by favouring early and frequent communication, awareness and use of the ‘rule of threes’ in media communication, open acknowledgement of uncertainty, prioritising response to community concern above narrow myth-busting strategies, and supporting community action.

  18. The amelioration effect of tranexamic acid in wrinkles induced by skin dryness.

    Science.gov (United States)

    Hiramoto, Keiichi; Sugiyama, Daijiro; Takahashi, Yumi; Mafune, Eiichi

    2016-05-01

    Tranexamic acid (trans-4-aminomethylcyclohexanecarboxylic acid) is a medical amino acid widely used as an anti-inflammatory and a whitening agent. This study examined the effect of tranexamic acid administration in wrinkle formation following skin dryness. We administered tranexamic acid (750mg/kg/day) orally for 20 consecutive days to Naruto Research Institute Otsuka Atrichia (NOA) mice, which naturally develop skin dryness. In these NOA mice, deterioration of transepidermal water loss (TEWL), generation of wrinkles, decrease of collagen type I, and increases in mast cell proliferation and tryptase and matrix metalloproteinase (MMP-1) release were observed. However, these symptoms were improved by tranexamic acid treatment. Moreover, the increase in the β-endorphin level in the blood and the expression of μ-opioid receptor on the surface of fibroblasts increased by tranexamic acid treatment. In addition, when the fibroblasts induced by tranexamic acid treatment were removed, the amelioration effect by tranexamic acid treatment was halved. On the other hand, tranexamic acid treated NOA mice and mast cell removal in tranexamic acid treated NOA mice did not result in changes in the wrinkle amelioration effect. Additionally, the amelioration effect of mast cell deficient NOA mice was half that of tranexamic acid treated NOA mice. These results indicate that tranexamic acid decreased the proliferation of mast cells and increases the proliferation of fibroblasts, subsequently improving wrinkles caused by skin dryness. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  19. Comparison of intracytoplasmic sperm injection with testicular spermatozoa success in infertile men with obstructive and non-obstructive azoospermia; a retrospective analysis.

    Science.gov (United States)

    Yalcin, Ibrahim; Berker, Bulent; Sukur, Yavuz Emre; Kahraman, Korhan; Ates, Can

    2017-09-01

    The aim of this study was to compare the outcome of intracytoplasmic sperm injection (ICSI) and embryo transfer between couples with infertility due to male non-obstructive azoospermia (NOA) and obstructive azoospermia (OA). A retrospective analysis of 234 couples with azoospermia who were treated by ICSI and embryo transfer between January 2007 and October 2010 was performed. There were 61 couples in NOA group and 173 couples in OA group. Fertilization rates, pregnancy and clinical pregnancy rates were the main outcome measures. The number of retrieved mature oocytes, injected oocytes, metaphase II (MII) oocytes, two distinct pronuclei oocytes, cleavage embryos and embryos transferred was not significantly different between the groups. The fertilization rate was significantly lower in NOA group when compared to OA group (56.2 vs. 66.7%, respectively; p = 0.013) and the pregnancy rate was significantly lower in NOA group than OA group (36.1 vs. 50.9%, respectively; p = 0.046). The clinical pregnancy rates were not statistically different between the patients with NOA and OA azoospermia groups (24.6 vs. 36.4%, respectively; p = 0.09). This study suggests that ICSI and embryo transfer together with testicular sperm extraction results in statistically significant lower fertilization and pregnancy rates in men with NOA when compared to men with OA.

  20. Electrowetting of liquid polymer on petal-mimetic microbowl-array surfaces for formation of microlens array with varying focus on a single substrate

    Science.gov (United States)

    Li, Xiangmeng; Shao, Jinyou; Li, Xiangming; Tian, Hongmiao

    2015-03-01

    In this paper, microlens array with varying focal lengths were fabricated on a single microbowl-array textured substrate. The solid microbowl-arrayed NOA61 (kind of polyurethane-based polymer with UV curablity) surface was resulted from nanoimprinting by polydimethylsiloxane (PDMS) mold. The PDMS mold was replicated from an SU-8 master which was generated by electron beam lithography. Such microbowl-arrayed surfaces demonstrate petal-mimetic highly adhesive hydrophobic wetting properties, which can promote an irreversible electrowetting (EW) effect and a dereased contact angle of water droplets as well as other liquid droplets by applying direct current (DC) voltage. To fabricate a microlens array with varying focal-lengths, liquid NOA61 was supplied from a syringe on the solid NOA61 microtextured film and DC voltage was applied succesively. After removing the DC voltage, these liquid NOA61 microdrops deposited on the solid microtextured NOA61 surface on tin-indium-oxide coated substrate could be solidified via UV irradiation, thus leading to microlens array with uneven numerical apertures on a single substrate. Numerical simulation was also done to verify the EW effect. Finally, optical imaging characterization was performed to confirm the varied focus of the NOA61 microdrops.

  1. Olympisme, francophonie et recherches académiques : quels rôles pour les académies olympiques francophones et quelles places pour les centres d'études olympiques ?

    Directory of Open Access Journals (Sweden)

    Richard Arnaud

    2016-01-01

    Not all National Olympic Committees (NOC over the world dispose or necessarily collaborate with National Olympic Academy (NOA. As an illustration, Cameroon NOA exists since 1994 and we are celebrating this year its twenty years anniversary (French NOA also. This preliminary remark is more important for National Olympic Study Centers (NOSC. None of them has got an official headquarters or attested activities in Africa. In this paper, we aim at a comparative structural study in connection between Olympics and academic research in three phases. Thus, we will proceed to an inventory of statement of the NOA in order to make an account of organizational typology, which will focus on the various links between NOCs and NOA in a general plan of education. From here, we would make proposals for the same type of approach towards the NOSC in order to account for the different methods of functioning of these research and studies centers. Finally, in a third phase we will cross the first two perspectives to demonstrate the correlation existing between NOCs, NOA and NOSC models. The objective of this contribution to the fifty years anniversary of the Cameroon National Olympic and Sports Committee is to open a debate within the Olympic Movement on the stakes and benefits of an increased and structured development in the domains of education and research related to Olympics.

  2. 2018-05-05T04:03:55Z https://www.ajol.info/index.php/all/oai oai:ojs ...

    African Journals Online (AJOL)

    ... di perle by Gabriella Ghermandi Sansalvadore, G Il romanzo Regina di fiori e di perle (2007) di Gabriella Ghermandi presentadue filoni narrativi: quello nel quale vengono raccolti oralmente i racconti deitestimoni degli anni coloniali sotto il fascismo, e quello del bildungsroman, nel quale il personaggio principale, Mahlet, ...

  3. Naturally occurring asbestos-A recurring public policy challenge

    Energy Technology Data Exchange (ETDEWEB)

    Lee, R.J.; Strohmeier, B.R. [RJ Lee Group, Inc., 350 Hochberg Road, Monroeville, PA 15146 (United States); Bunker, K.L. [RJ Lee Group, Inc., 350 Hochberg Road, Monroeville, PA 15146 (United States)], E-mail: klbunker@rjlg.com; Van Orden, D.R. [RJ Lee Group, Inc., 350 Hochberg Road, Monroeville, PA 15146 (United States)

    2008-05-01

    The potential environmental hazards and associated public health issues related to exposure to respirable dusts from the vicinity of natural in-place asbestos deposits (commonly referred to as naturally occurring asbestos, NOA) have gained the regulatory and media spotlight in many areas around the United States, such as Libby, MT, Fairfax County, VA, and El Dorado Hills, CA, among others. NOA deposits may be present in a variety of geologic formations. It has been suggested that airborne asbestos may be released from NOA deposits, and absent appropriate engineering controls, may pose a potential health hazard if these rocks are crushed or exposed to natural weathering and erosion or to human activities that create dust. The issue that needs to be addressed at a policy level is the method of assessing exposures to elongated rock fragments ubiquitous in dust clouds in these same environments and the associated risk. Elongated rock fragments and single crystal minerals present in NOA have been construed by some as having attributes, including the health effects, of asbestos fibers. However, the Occupational Safety and Health Administration (OSHA), Mine Safety and Health Administration (MSHA), and the Consumer Products Safety Commission (CPSC) found that the scientific evidence did not support this assumption. As in many environmental fields of study, the evidence is often disputed. Regulatory policy is not uniform on the subject of rock fragments, even within single agencies. The core of the issue is whether the risk parameters associated with exposures to commercial asbestos can or should be applied to rock fragments meeting an arbitrary set of particle dimensions used for counting asbestos fibers. Inappropriate inclusion of particles or fragments results in dilution of risk and needless expenditure of resources. On the other hand, inappropriate exclusion of particles or fragments may result in increased and unnecessary risk. Some of the fastest growing counties in

  4. Naturally occurring asbestos-A recurring public policy challenge

    International Nuclear Information System (INIS)

    Lee, R.J.; Strohmeier, B.R.; Bunker, K.L.; Van Orden, D.R.

    2008-01-01

    The potential environmental hazards and associated public health issues related to exposure to respirable dusts from the vicinity of natural in-place asbestos deposits (commonly referred to as naturally occurring asbestos, NOA) have gained the regulatory and media spotlight in many areas around the United States, such as Libby, MT, Fairfax County, VA, and El Dorado Hills, CA, among others. NOA deposits may be present in a variety of geologic formations. It has been suggested that airborne asbestos may be released from NOA deposits, and absent appropriate engineering controls, may pose a potential health hazard if these rocks are crushed or exposed to natural weathering and erosion or to human activities that create dust. The issue that needs to be addressed at a policy level is the method of assessing exposures to elongated rock fragments ubiquitous in dust clouds in these same environments and the associated risk. Elongated rock fragments and single crystal minerals present in NOA have been construed by some as having attributes, including the health effects, of asbestos fibers. However, the Occupational Safety and Health Administration (OSHA), Mine Safety and Health Administration (MSHA), and the Consumer Products Safety Commission (CPSC) found that the scientific evidence did not support this assumption. As in many environmental fields of study, the evidence is often disputed. Regulatory policy is not uniform on the subject of rock fragments, even within single agencies. The core of the issue is whether the risk parameters associated with exposures to commercial asbestos can or should be applied to rock fragments meeting an arbitrary set of particle dimensions used for counting asbestos fibers. Inappropriate inclusion of particles or fragments results in dilution of risk and needless expenditure of resources. On the other hand, inappropriate exclusion of particles or fragments may result in increased and unnecessary risk. Some of the fastest growing counties in

  5. Naturally occurring asbestos: a recurring public policy challenge.

    Science.gov (United States)

    Lee, R J; Strohmeier, B R; Bunker, K L; Van Orden, D R

    2008-05-01

    The potential environmental hazards and associated public health issues related to exposure to respirable dusts from the vicinity of natural in-place asbestos deposits (commonly referred to as naturally occurring asbestos, NOA) have gained the regulatory and media spotlight in many areas around the United States, such as Libby, MT, Fairfax County, VA, and El Dorado Hills, CA, among others. NOA deposits may be present in a variety of geologic formations. It has been suggested that airborne asbestos may be released from NOA deposits, and absent appropriate engineering controls, may pose a potential health hazard if these rocks are crushed or exposed to natural weathering and erosion or to human activities that create dust. The issue that needs to be addressed at a policy level is the method of assessing exposures to elongated rock fragments ubiquitous in dust clouds in these same environments and the associated risk. Elongated rock fragments and single crystal minerals present in NOA have been construed by some as having attributes, including the health effects, of asbestos fibers. However, the Occupational Safety and Health Administration (OSHA), Mine Safety and Health Administration (MSHA), and the Consumer Products Safety Commission (CPSC) found that the scientific evidence did not support this assumption. As in many environmental fields of study, the evidence is often disputed. Regulatory policy is not uniform on the subject of rock fragments, even within single agencies. The core of the issue is whether the risk parameters associated with exposures to commercial asbestos can or should be applied to rock fragments meeting an arbitrary set of particle dimensions used for counting asbestos fibers. Inappropriate inclusion of particles or fragments results in dilution of risk and needless expenditure of resources. On the other hand, inappropriate exclusion of particles or fragments may result in increased and unnecessary risk. Some of the fastest growing counties in

  6. Relationships of occupational and non-occupational physical activity to abdominal obesity.

    Science.gov (United States)

    Steeves, J A; Bassett, D R; Thompson, D L; Fitzhugh, E C

    2012-01-01

    Physically active occupations may protect against the risk of abdominal obesity. This study assessed the interaction between non-occupational physical activity (NOA) (leisure-time, transport and domestic activity) and occupational activity (OA) in relation to abdominal obesity. A total of 3539 adults over the age of 20, with no work limitations, employed in one of the 17 occupations classified as low OA (LOA) or high OA (HOA) were identified in the 1999-2004 National Health and Nutrition Examination Survey. Waist circumference (WC) was used to categorize individuals into either non-obese or abdominally obese (WC>88 cm in women and >102 cm in men) categories. NOA was divided into three categories based upon physical activity guidelines: (1) no NOA; (2) insufficient NOA; and (3) sufficient NOA. Logistic regression was used to examine possible associations between NOA, OA and abdominal obesity. In those who are sedentary outside of work, a high-activity occupation reduces the odds risk ratio of being categorized with abdominal obesity to 0.37 in comparison with those who work in low-activity occupations. For people working in low-activity occupations, there was a clear association with activity outside of work and the odds risk ratio of being categorized with abdominal obesity. In these adults, a reduced odds ratio was found only among those who met the physical activity guidelines through NOA (odds ratio=0.55; 95% confidence interval (CI)=0.40-0.75). HOA is associated with a reduced risk of abdominal obesity. Thus, it is important to include OA in studies seeking to understand the association between physical activity and abdominal adiposity.

  7. The cyanobacterial metabolite nocuolin a is a natural oxadiazine that triggers apoptosis in human cancer cells.

    Directory of Open Access Journals (Sweden)

    Kateřina Voráčová

    Full Text Available Oxadiazines are heterocyclic compounds containing N-N-O or N-N-C-O system within a six membered ring. These structures have been up to now exclusively prepared via organic synthesis. Here, we report the discovery of a natural oxadiazine nocuolin A (NoA that has a unique structure based on 1,2,3-oxadiazine. We have identified this compound in three independent cyanobacterial strains of genera Nostoc, Nodularia, and Anabaena and recognized the putative gene clusters for NoA biosynthesis in their genomes. Its structure was characterized using a combination of NMR, HRMS and FTIR methods. The compound was first isolated as a positive hit during screening for apoptotic inducers in crude cyanobacterial extracts. We demonstrated that NoA-induced cell death has attributes of caspase-dependent apoptosis. Moreover, NoA exhibits a potent anti-proliferative activity (0.7-4.5 μM against several human cancer lines, with p53-mutated cell lines being even more sensitive. Since cancers bearing p53 mutations are resistant to several conventional anti-cancer drugs, NoA may offer a new scaffold for the development of drugs that have the potential to target tumor cells independent of their p53 status. As no analogous type of compound was previously described in the nature, NoA establishes a novel class of bioactive secondary metabolites.

  8. Environmental exposure to asbestos: from geology to mesothelioma.

    Science.gov (United States)

    Bayram, Mehmet; Bakan, Nur Dilek

    2014-05-01

    This article aims to review the geological background of environmental asbestos exposure and the distribution of asbestos-related disease (ARD) in association with naturally occurring asbestos (NOA), and discusses the potential health risks associated with exposure to non-occupational asbestos. With the motion of continental and oceanic plates, in some parts of the world serpentinites in the lower layer of the oceanic plate move into the continental plate and form the so-called ophiolites. Ophiolites consist of soil and rocks containing serpentine-type asbestos. There is an increase in ARDs in regions close to ophiolites. Indoor exposure and outdoor exposure to NOA, outdoor exposure to industrial asbestos and mines, urbanization and construction works in NOA regions are the known sources and types of environmental asbestos exposure. Although there is an expectance of decline in ARDs caused by industrial exposure to asbestos, the environmental exposure to asbestos is still a challenge waiting to be overcome.

  9. Personal Change and Intervention Style

    Science.gov (United States)

    Andrews, John D. W.

    1977-01-01

    Presents a theory of personal change and analyzes growth-producing interventions using examples from the film, "Three Approaches to Psychotherapy". Compares the styles of Carl Rogers, Frttz Perls, and Albert Ellis to illustrate the theory. (Editor/RK)

  10. TDT-2002 Topic Tracking at Maryland: First Experiments with the Lemur Toolkit

    National Research Council Canada - National Science Library

    He, Daqing; Park, Hyuk R; Murray, G. C; Subotin, Michael; Oard, Douglas W

    2003-01-01

    .... Two of the Perl runs used native Arabic orthography with two-best translation based on a statistical lexicon, obtaining similar results to those obtained with the Arabic-to-English translations...

  11. Presidential Electronic Records Library

    Data.gov (United States)

    National Archives and Records Administration — PERL (Presidential Electronic Records Library) used to ingest and provide internal access to the Presidential electronic Records of the Reagan, Bush, and Clinton...

  12. Pärlid juveelide kuningannad / Riina Robinson

    Index Scriptorium Estoniae

    Robinson, Riina

    2008-01-01

    Pärlite erinevatest kasutusviisidest. Pärlite kandmise ajaloost. Kuulsad pärlid: Pearl of Allah, La Peregrina, La Pellegrina, La Perle Napoleon. Kunstpärlite tootmisest. Pärlite kasvatamisest Jaapanis

  13. Le temps d'un week-end, Genève fait l'école buissonnière

    CERN Multimedia

    Grosjean, Antoine

    2002-01-01

    The third "Night of Science" captivated between 25 000 and 30 000 visitors at the Perle-du-Lac. Scientists were present from the start of the afternoon until midnight to demonstrate experiments associated with light

  14. XAMPP: Problemas

    OpenAIRE

    Luján Mora, Sergio

    2013-01-01

    Dos problemas muy comunes, y sus soluciones, que pueden ocurrir con XAMPP, la plataforma de desarrollo para los sistemas operativos Linux, Windows, MacOS X y Solaris que incluye Apache, MySQL, PHP y Perl.

  15. Author Details

    African Journals Online (AJOL)

    AHP) Model Abstract · Vol 18 (2011) - Articles Adaptive Kernel In The Bootstrap Boosting Algorithm In KDE Abstract · Vol 18 (2011) - Articles An Empirical Comparison of HTML, PHP, COLDFUSION, PERL, ASP.net, Javascript, VBScript, Pyton and ...

  16. Enhancements to Time.Gov: The National Web Clock for the United States

    National Research Council Canada - National Science Library

    Novick, Andrew N; Ou, Samuel

    2007-01-01

    .... Switching the interface from the Java/Perl environments to using Flash and XML has improved the efficiency on the server side and increased ease of use for the variety of clients and firewall settings...

  17. The Design and Implementation of a Prototype Web-Portal for the Integrated Mobile Alerting System (IMAS)

    Science.gov (United States)

    2006-06-01

    employed in small to medium sized applications. Its cost and ease of management allow beginners to easily develop their own databases within...that it can run stored procedures written with various programming languages such as C/C++, Perl, Java, and Python . Unlike MySQL, PostgreSQL fully...server combination utilizes the LAMP configuration. LAMP stands 38 for Linux, Apache, MySQL, and Perl/PHP/ Python . IMAS utilizes the LAMP

  18. Open Scenario Study, Phase II Report: Assessment and Development of Approaches for Satisfying Unclassified Scenario Needs

    Science.gov (United States)

    2010-01-01

    Oracle) • Mysql (Open Source) • Other What application server software will be needed? • Application Server • CGI PHP /Perl (Open Source...CGI PHP /Perl (Other Open Source software) • ColdFusion (Adobe) • OAS Application Server (Oracle) • .ASP/.NET (Microsoft) • Inmagic DB/textworks I...developers around the world. 9 • Ms Windows® – Microsoft Windows operating system for personal computers • MySQL (Open Source) - the most reliable

  19. Potencial territorial e integración económica en América del Sur: el caso del noroeste argentino

    Directory of Open Access Journals (Sweden)

    Álvaro Sánchez Crispín

    2000-01-01

    Full Text Available This paper deals with the issue of the strategic location of the Argentinean Northwest (NOA, a region wich may well play a significant role in the process of economic and political integration, taking place in South America. There are two parts in the paper: the first examines the trends in economic integration pursued by Argentina in the last few years, The second part reveals the role of the geographical individuality of the NOA regarding the economic integration of the area to the rest of the South American continent.

  20. Hematoxylin and eosin stain shows a high sensitivity but sub-optimal specificity in demonstrating iron pigment in liver biopsies.

    Science.gov (United States)

    Alwahaibi, Nasar Yousuf; Alkhatri, Azza Sarhan; Kumar, Johanes Selva

    2015-01-01

    Perls' stain is routinely used to demonstrate iron in liver biopsies. We tested the hypothesis that it may be unnecessary in cases, where no iron or another similar pigment was seen on the routine hematoxylin and eosin (H and E) stained section. The aim of this study was to evaluate the efficiency of H and E stain in demonstrating iron in liver biopsies as well as to determine the possibility of replacing Perls' stain with H and E stain. Two hundred pairs of slides of liver biopsies were taken from the archival files of the Department of Pathology from 2006 to 2011. Perls' and H and E slides were independently reviewed for the presence of iron. Hundred and one cases showed the presence of iron using H and E stain. 84 of 86 cases showed positive iron using both Perls' and H and E stains. Seventeen cases were positive using H and E stain but negative with Perls'. Only two cases did not show the presence of iron using H and E stain. Ninety-seven cases were negative using both Perls' and H and E stains. H and E stain showed a sensitivity, specificity, accuracy, positive predictive valve, and negative predictive value of 97.67%, 85.08%, 90.5%, 83.16%, and 97.98%, respectively. We demonstrate that the H and E stain is a sensitive method to detect iron pigment in liver biopsies, particularly when present in large quantities. A negative H and E stain might obviate the need for extra Perls' staining, thus saving costs and shortening report turn-around times.

  1. Analytic reconstruction of magnetic resonance imaging signal obtained from a periodic encoding field.

    Science.gov (United States)

    Rybicki, F J; Hrovat, M I; Patz, S

    2000-09-01

    We have proposed a two-dimensional PERiodic-Linear (PERL) magnetic encoding field geometry B(x,y) = g(y)y cos(q(x)x) and a magnetic resonance imaging pulse sequence which incorporates two fields to image a two-dimensional spin density: a standard linear gradient in the x dimension, and the PERL field. Because of its periodicity, the PERL field produces a signal where the phase of the two dimensions is functionally different. The x dimension is encoded linearly, but the y dimension appears as the argument of a sinusoidal phase term. Thus, the time-domain signal and image spin density are not related by a two-dimensional Fourier transform. They are related by a one-dimensional Fourier transform in the x dimension and a new Bessel function integral transform (the PERL transform) in the y dimension. The inverse of the PERL transform provides a reconstruction algorithm for the y dimension of the spin density from the signal space. To date, the inverse transform has been computed numerically by a Bessel function expansion over its basis functions. This numerical solution used a finite sum to approximate an infinite summation and thus introduced a truncation error. This work analytically determines the basis functions for the PERL transform and incorporates them into the reconstruction algorithm. The improved algorithm is demonstrated by (1) direct comparison between the numerically and analytically computed basis functions, and (2) reconstruction of a known spin density. The new solution for the basis functions also lends proof of the system function for the PERL transform under specific conditions.

  2. 77 FR 39506 - Notice of Inventory Completion: Bishop Museum, Honolulu, HI

    Science.gov (United States)

    2012-07-03

    ... Inventory Completion: Bishop Museum, Honolulu, HI AGENCY: National Park Service, Interior. ACTION: Notice... 2, 2012. ADDRESSES: Noa Dettweiler, General Counsel, Bishop Museum, Honolulu, HI 96817, telephone..., General Counsel, Bishop Museum, 1525 Bernice Street, Honolulu, HI 96817, telephone (808) 847-8216, before...

  3. 76 FR 28757 - Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense...

    Science.gov (United States)

    2011-05-18

    ... DEPARTMENT OF DEFENSE Office of the Secretary [DOCKET ID DOD-2011-OS-0055] Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense Logistics Agency Actions AGENCY: Defense Logistics Agency, Department of Defense. ACTION: Notice of Availability (NOA) of Revised...

  4. Na grebnje volnõ / Nikolai Hrustaljov

    Index Scriptorium Estoniae

    Hrustaljov, Nikolai

    2002-01-01

    Vene režissöör Juri Kuzin, kes vene kultuuri tutvustuva "Kultuurimissiooni" raames tutvustab tallinlastele oma lühimängufilmi "Ljovsha" ("Junõje godõ Adolfa Gitlera") ning katkendeid oma uuest mängufilmist "Noa laev" ("Kovtsheg")

  5. 75 FR 63517 - Notice of Availability of the Record of Decision for Environmental Impact Statement for the...

    Science.gov (United States)

    2010-10-15

    ... NATIONAL INDIAN GAMING COMMISSION Notice of Availability of the Record of Decision for..., CA AGENCY: National Indian Gaming Commission (NIGC). ACTION: Notice of Availability (NOA). SUMMARY..., including directions and office hours is available online at: http://www.sonoma.lib.ca.us/branches/ or by...

  6. 76 FR 30696 - Technology Evaluation Process

    Science.gov (United States)

    2011-05-26

    ...-NOA-0039] Technology Evaluation Process AGENCY: Office of Energy Efficiency and Renewable Energy... (DOE) seeks comments and information related to a commercial buildings technology evaluation process... evaluation efforts. The goal of creating this standard process is to evaluate energy-saving technologies in a...

  7. 76 FR 37344 - Technology Evaluation Process

    Science.gov (United States)

    2011-06-27

    ...-NOA-0039] Technology Evaluation Process AGENCY: Office of Energy Efficiency and Renewable Energy... seeks comments and information related to a commercial buildings technology evaluation process. DOE is seeking to create a process for evaluating emerging and underutilized energy efficient technologies for...

  8. An Improved Model for Operational Specification of the Electron Density Structure up to Geosynchronous Heights

    Science.gov (United States)

    2010-07-01

    http://www.iono.noa.gr/ElectronDensity/EDProfile.php The web service has been developed with the following open source tools: a) PHP , for the... MySQL for the database, which was based on the enhancement of the DIAS database. Below we present some screen shots to demonstrate the functionality

  9. Reference Aid Abbreviations in the Latin American Press

    Science.gov (United States)

    1977-08-30

    Argentino de Investigacion y Ensayo de Materiales CADIN Camara de Industrias de Nicaragua CADSE Comision Asesora de los Delitos Socio...IMC Industria de Materiales para la Construccion Instituto Mexicano del Cafe IMCE Instituto Mexicano de Comercio Exterior IMCIC Instituto...Generations (Gua) Revolucionarias NMU NNUU Naciones Unidas NOA Nueva Organizacion Anticomunista NON Nuevo Orden Nacional NORMETAL Empresa

  10. Denitrification potential in sediments of headwater streams in the southern appalachian mountains, USA

    Science.gov (United States)

    Lara A. Martin; Patrick J. Mulholland; Jackson R. Webster; H. Maurice Vallett

    2001-01-01

    We investigated variations in resource availability (NOa-N and labile organic C [LOCJ] as determinants of potential denitrification in stream sediments in the southern Appalachian Mountains, USA. stream-water and sediments were sampled seasonally in 2 streams of contrasting NO3,-N availability, Noland Creek (high NO

  11. 77 FR 5560 - Commercial Wind Lease Issuance and Site Assessment Activities on the Atlantic Outer Continental...

    Science.gov (United States)

    2012-02-03

    ....gov/Renewable-Energy-Program/Smart-from-the-Start/Index.aspx . Authority: This NOA of an EA and FONSI... Interior Ken Salazar announced the ``Smart from the Start'' renewable energy initiative to accelerate the... additional opportunities for public involvement pursuant to NEPA and the White House Council on Environmental...

  12. 78 FR 64242 - Outer Continental Shelf (OCS), Gulf of Mexico (GOM), Oil and Gas Lease Sales, Western Planning...

    Science.gov (United States)

    2013-10-28

    ... (NOA) of the Draft Supplemental Environmental Impact Statement (EIS) and Public Meetings. SUMMARY: BOEM... Impact Statement (OCS EIS/EA BOEM 2012-019) (2012- 2017 WPA/CPA Multisale EIS) and in the Gulf of Mexico... Lease Sale 231, Final Supplemental Environmental Impact Statement (OCS EIS/EA BOEM 2013-0118) (WPA 233...

  13. 78 FR 21969 - Gulf of Mexico (GOM), Outer Continental Shelf (OCS), Western Planning Area (WPA) Lease Sale 233...

    Science.gov (United States)

    2013-04-12

    .... ACTION: Notice of Availability (NOA) of the Final Supplemental Environmental Impact Statement (EIS... Environmental Impact Statement (OCS EIS/EA BOEM 2012-019) (2012-2017 Multisale EIS), completed in July 2012, in... to the cumulative impacts on environmental and socioeconomic resources. The oil and gas resource...

  14. 78 FR 9731 - Gulf of Mexico, Outer Continental Shelf (OCS), Central Planning Area (CPA) Oil and Gas Lease Sale...

    Science.gov (United States)

    2013-02-11

    ... Environmental Impact Statement (Multisale FEIS). Authority: This NOA is published pursuant to the regulations... the NEPA process. The Multisale FEIS evaluated the environmental and socioeconomic impacts for CPA... DEPARTMENT OF THE INTERIOR Bureau of Ocean Energy Management Gulf of Mexico, Outer Continental...

  15. 77 FR 68147 - Gulf of Mexico, Outer Continental Shelf (OCS), Western Planning Area (WPA), Oil and Gas Lease...

    Science.gov (United States)

    2012-11-15

    ... Environmental Impact Statement (Multisale FEIS). Authority: This NOA is published pursuant to the regulations... NEPA process. The Multisale FEIS evaluated the environmental and socioeconomic impacts for WPA Lease... DEPARTMENT OF THE INTERIOR Bureau of Ocean Energy Management Gulf of Mexico, Outer Continental...

  16. 76 FR 50245 - Gulf of Mexico (GOM), Outer Continental Shelf (OCS), Western Planning Area (WPA), Oil and Gas...

    Science.gov (United States)

    2011-08-12

    ... (BOEMRE), Interior. ACTION: Notice of Availability (NOA) of a Final Supplemental Environmental Impact... sale's incremental contribution to the cumulative impacts on environmental and socioeconomic resources... Mexico (GOM), Outer Continental Shelf (OCS), Western Planning Area (WPA), Oil and Gas Lease Sale for the...

  17. 75 FR 27926 - Notice of Availability of Interpretive Rule on the Applicability of Current Water Conservation...

    Science.gov (United States)

    2010-05-19

    ... DEPARTMENT OF ENERGY 10 CFR Part 430 [Docket No. EERE-2010-BT-NOA-0016] Notice of Availability of Interpretive Rule on the Applicability of Current Water Conservation Standards for Showerheads; Request for Comments AGENCY: Department of Energy. ACTION: Notice of availability and request for comments. SUMMARY...

  18. The World's Approach toward Publishing in Springer and Elsevier's APC-Funded Open Access Journals

    Science.gov (United States)

    Sotudeh, Hajar; Ghasempour, Zahra

    2018-01-01

    Purpose: The present study explored tendencies of the world's countries--at individual and scientific development levels--toward publishing in APC-funded open access journals. Design/Methodology/Approach: Using a bibliometric method, it studied OA and NOA articles issued in Springer and Elsevier's APC journals? during 2007-2011. The data were…

  19. 78 FR 48852 - Magnuson-Stevens Fishery Conservation and Management Act Provisions; Fisheries of the...

    Science.gov (United States)

    2013-08-12

    ... envelope, ``Comments on MSB Amendment 14 NOA.'' Fax: (978) 281-9135, Attn: Aja Szumylo. Instructions... compromises the safety of the vessel, (2) mechanical failure prevents the catch from being brought aboard, or... slipping was safety or mechanical failure, would be required to return to port. This aspect of the measure...

  20. 76 FR 70478 - Gulf of Mexico (GOM), Outer Continental Shelf (OCS), Western Planning Area (WPA), Oil and Gas...

    Science.gov (United States)

    2011-11-14

    ... DEPARTMENT OF THE INTERIOR Bureau of Ocean Energy Management Gulf of Mexico (GOM), Outer... studies, NEPA analysis, resource evaluation, economic analysis, and renewable energy. BSEE is responsible... Program AGENCY: Bureau of Ocean Energy Management (BOEM), Interior. ACTION: Notice of Availability (NOA...

  1. Wafer-scale fabrication of glass-FEP-glass microfluidic devices for lipid bilayer experiments

    NARCIS (Netherlands)

    Bomer, Johan G.; Prokofyev, A.V.; van den Berg, Albert; le Gac, Severine

    2014-01-01

    We report a wafer-scale fabrication process for the production of glass-FEP-glass microdevices using UV-curable adhesive (NOA81) as gluing material, which is applied using a novel "spin & roll" approach. Devices are characterized for the uniformity of the gluing layer, presence of glue in the

  2. Relating Images, Concepts, and Words.

    Science.gov (United States)

    1979-01-01

    similarity metric and links fo r relatedness. Evidence from language for different kinds of mappings 4 In this section I present more detailed...ua ae mpe noa airpane nd amoutainfromthe tor " Pedo " i Wat Dineys Trasuy, Glde Press NowYork,1953 Page 16 Figure 4 "Collective invention" (1935) by Rene

  3. Journal of the Nigerian Optometric Association

    African Journals Online (AJOL)

    ... in the broad fields of Optometry and Health Sciences, providing a medium for ... journal will feature an online publication on NOA website, www.noang.org. To reach a worldwide audience, the full text is published at http://www.ajol.info/ajol/ .

  4. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics. POMITA GHOSHAL. Articles written in Pramana – Journal of Physics. Volume 86 Issue 2 February 2016 pp 387-393 Special: Neutrino Physics. Evidence for leptonic CP phase from NOA, T2K and ICAL · Monojit Ghosh Pomita Ghoshal Srubabati Goswami Sushant K Raut.

  5. Vertically transmitted HIV-l infection in children

    African Journals Online (AJOL)

    1990-08-09

    Aug 9, 1990 ... Rogers MF, Thomas PA, Starcher ET, Noa MC, Bush TJ, Jaffe HW. Acquired immunodeficiency syndrome in children: report of tbe Centers for. Disease Control national surveillance, 1982-1985. Pediaerics 1987; 79: 1008-1014. 16. Ryder RW, Nsa, W, Hassig SE ec al. Perinatal transmission of the human.

  6. Effect of the male factor on the clinical outcome of intracytoplasmic sperm injection combined with preimplantation aneuploidy testing: observational longitudinal cohort study of 1,219 consecutive cycles.

    Science.gov (United States)

    Mazzilli, Rossella; Cimadomo, Danilo; Vaiarelli, Alberto; Capalbo, Antonio; Dovere, Lisa; Alviggi, Erminia; Dusi, Ludovica; Foresta, Carlo; Lombardo, Francesco; Lenzi, Andrea; Tournaye, Herman; Alviggi, Carlo; Rienzi, Laura; Ubaldi, Filippo Maria

    2017-12-01

    To evaluate the impact of the male factor on the outcomes of intracytoplasmic sperm injection (ICSI) cycles combined with preimplantation genetic testing for aneuploidies (PGT-A). Observational longitudinal cohort study. Private in vitro fertilization (IVF) center. A total of 1,219 oocyte retrievals divided into five study groups according to sperm parameters: normozoospermia (N), moderate male factor (MMF), severe oligoasthenoteratozoospermia (OAT-S), obstructive azoospermia (OA), and nonobstructive azoospermia (NOA). ICSI with ejaculated/surgically retrieved sperm, blastocyst culture, trophectoderm-based quantitative polymerase chain reaction PGT-A, and frozen-warmed euploid embryo transfer (ET). The primary outcome measures were fertilization, blastocyst development, and euploidy rates; the secondary outcome measures were live birth and miscarriage rates. Perinatal and obstetrical outcomes were monitored as well. A total of 9,042 metaphase II oocytes were inseminated. The fertilization rate was significantly reduced in MMF, OAT-S, OA, and NOA compared with N (74.8%, 68.7%, 67.3%, and 53.1% vs. 77.2%). The blastocyst rate per fertilized oocyte was significantly reduced in MMF and NOA compared with N (48.6% and 40.6% vs. 49.3%). The timing of blastocyst development also was affected in OA and NOA. Logistic regression analysis adjusted for confounders highlighted NOA as a negative predictor of obtaining an euploid blastocyst per OPU (odds ratio 0.5). When the analysis was performed per obtained blastocyst, however, no correlation between male factor and euploidy rate was observed. Embryo transfers also resulted in similar live birth and miscarriage rates. No impact of sperm factor on obstetrical/perinatal outcomes was observed. Severe male factor impairs early embryonic competence in terms of fertilization rate and developmental potential. However, the euploidy rate and implantation potential of the obtained blastocysts are independent from sperm quality

  7. The response of leaves to heat stress in tomato plants with source-sink modulated by growth regulators

    Directory of Open Access Journals (Sweden)

    Zofia Starck

    2014-01-01

    Full Text Available The response to heat stress was investigated in heat-sensitive, Roma V. F. and heat-tolerant, Robin, cultivars whose fruit growth was stimulated by NOA + GA3 , or NOA + GA3 + zeatin. The treated plants were compared with untreated control plant. In each of these series half of the plants were subjected to one or three cycles of heat stress. A single cycle of 38°/25°C day and night did not significantly affect either the respiration rate or chlorophyll content. In PGR-untreated intact cv. Roma, heat stress inhibited starch formation during the day and strongly depressed night export from the blades. High temperature depressed the night transport less in plants having a higher sink demand of fruits in plant treated with PGR. In this case the amount of substances available for export was much higher and both sugars and starch were more intensively remobilized at night. In intact Robin plants, PGR and heat stress much less affected sugar and starch content. High temperature diminished noctural starch remobilization only in the NOA + GA3 series. Leaf disc growth was evaluated as a measure of response to heat stress after elimination of the direct effect of fruit demands. One cycle of high temperature did not negatively affect the growth of leaf discs; it even caused thermal low growth activation in both cultivars. Three cycles of heat stress depressed leaf disc growth after short-term stimulation, especially in Roma plants. Immediately after 3-day heat stress, there was no response of discs to GA3 or zeatin added to the solution on which the discs were floated. Leaf disc growth of Robin control and NOA + GA3 series was very similar in plants from optimal temperature conditions. High temperature inhibited only disc growth of the NOA + GA3 series owing to depression of starch break-down, diminishing the pool of sugars. In contrast, leaf discs of Roma cv. excided from NOA + GA3 treated plants from the optimal temperature series, grew more intensively

  8. Production of electronically excited NO via DEA to NO2

    Science.gov (United States)

    Gope, Krishnendu; Tadsare, Vishvesh; Prabhudesai, Vaibhav S.; Krishnakumar, E.

    2017-12-01

    Dissociative electron attachment (DEA) to NO2 in the 7-11 eV range is studied using velocity slice imaging technique. Two distinct channels are observed in the DEA corresponding to O- + NO(A 2Σ+) and O- + NO(C 2Π and/or D 2Σ+). While NO(A 2Σ+) is found to be formed only in very high vibrational levels, NO(C 2Π and/or D 2Σ+) is found to be formed with vibrational distribution starting from v = 0. From the angular distribution of the O- ions leading to the NO(C 2Π and/or D 2Σ+) channel, we obtain the symmetry of the negative ion resonance to be dominantly B1 with small contribution from B2. Contribution to the Topical Issue: "Low Energy Positron and Electron Interactions", edited by James Sullivan, Ron White, Michael Bromley, Ilya Fabrikant, and David Cassidy.

  9. Euroopa kultuurilinn Riia ja kunst / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    2001-01-01

    Euroopa kultuuripealinna Riia kunstisündmusi: 29.-31. VIII videopäevad "Veepiisad" Noa galeriis, 7.-15. IX jätkub rahvusvaheline uue meedia festival "Kunst ja kommunikatsioon 2001", 8. IX performance "Signal Sever!", 9.-14. IX video-audioworkshop Riias, 14.-15. IX digitaalse meediakunsti ja klubikultuuri projekt "Hip Hop Lv" jm. Internetis: virtual.riga2001.lv

  10. Sealpool nukkude orgu asub pop-voodoo / Aleksander Tsapov

    Index Scriptorium Estoniae

    Tsapov, Aleksander

    2006-01-01

    Ekstsentrilisest disainist. Raffaele Ianello ja Irene van Gesteli noa- ja hambaorgihoidjad, Philippe Starcki ja Critz Campbelli tugitool-valgustid, August de Martinville'i papist jahitrofee, Sebastian E. partlamp, Isabelle Leijni keraamilised kiivrid, Harry Alleni hoiupõrsas jm. High-tech kodusisustuse näiteid: Jackie Shapiro disainitud taldrikud, Frank Gehry sofa, Ingo Maureri Campari Soda lamp, Sonya Chow siilvalgusti, Mathias Bengtssoni (sünd. 1971) alumiiniumtool, Piet Houtenbosi õlilambid jm.

  11. Perfil antropométrico en adultos del noroeste argentino: comparación con una referencia internacional

    Directory of Open Access Journals (Sweden)

    Lomaglio, Delia Beatriz

    2015-01-01

    Full Text Available Desde una perspectiva bioantropológica las mediciones antropométricas en adultos son exhaustivamente utilizadas en la evaluación morfológica de poblaciones argentinas extintas. La mayoría de los estudios antropométricos en adultos argentinos contemporáneos se limitan a la evaluación de talla, peso e IMC. El objetivo de este trabajo fue describir otras variables antropométricas en adultos del Noroeste argentino (NOA y compararlas con una referencia internacional. Los datos de peso, talla, perímetros (brazo, muslo, pierna, cintura y pliegues (tríceps, subescapular proceden de 881 individuos (526 mujeres; 355 varones sanos de 20-60 años de edad de distintas localidades de Catamarca y Jujuy. Se calcularon estadísticos descriptivos (media y DS por sexo y dos PALABRAS CLAVE adultos; Noroeste Argentino; perímetros; pliegues; antropometría grupos de edad: 20-39 y 40-60 años. Las comparaciones se establecieron con adultos de EEUU de origen mejicano (Centers for Disease Control, CDC 2003-2006 con la prueba t. Se calcularon los percentilos con el método LMS. En ambos sexos y grupos de edad los adultos del NOA presentaron valores significativamente inferiores a los de la referencia en todas las variables consideradas, excepto para pliegues tricipital y subescapular en varones de 40-60 años. No se han encontrado antecedentes antropométricos comparables semejantes para poblaciones argentinas y del NOA. El perfil antropométrico de los adultos del NOA difiere significativamente con respecto a la población de referencia con un origen étnico afín.

  12. Quantitative weight of evidence assessment of higher tier studies on the toxicity and risks of neonicotinoids in honeybees. 3. Clothianidin.

    Science.gov (United States)

    Solomon, Keith R; Stephenson, Gladys L

    2017-01-01

    A quantitative weight of evidence (QWoE) methodology was used to assess higher tier studies on the effects of clothianidin (CTD) on honeybees. Assessment endpoints were population size and viability of commercially managed bees and quantity of hive products. A colony-level no-observed-adverse effect concentration (NOAEC) of 25 µg CTD/kg syrup, equivalent to an oral no-observed-adverse effect-dose (NOAED) of 7.3 ng/bee/d for all responses measured. Based on a NOAEC of 19.7 µg/kg pollen, the NOAED for honeybee larvae was 2.4 ng/bee larva/d. For exposures via dust, a no-observed-adverse effect rate of 4 g CTD/ha was used to assess relevance of exposures via deposition of dust. The overall weight of evidence suggested that there is minimal risk to honeybees from exposure to CTD from its use as a seed treatment. For exposures via dust, dust/seed and dust/foliar applications, there were no exposures greater than the NOAED for CTD in nectar and pollen, indicating a de minimis risk to honeybees when the route of exposure was via uptake in plants. Analysis of effect studies in the field indicated a consistent lack of relevant effects, regardless of the way CTD was applied. For exposures via dust, there were no adverse effects because of these applications and there were no exposures greater than the NOAED for CTD in nectar and pollen. The overall weight of evidence based on many studies indicated no adverse effects on colony viability or survival of the colony. Thus, the overall conclusion is that clothianidin, as currently used in good agricultural practices, does not present a significant risk to honeybees at the level of the colony.

  13. Laul lunastusest maitsvate roogade läbi : [luuletused] / Wimberg

    Index Scriptorium Estoniae

    Wimberg, pseud., 1979-

    2007-01-01

    Sisu: Laul lunastusest maitsvate roogade läbi; Olen väike rallifänn; Poeedi praktikast; Minu patent-bändiprojekt; Ülistus postimüügi kataloogile; Mina küll ei taha olla megastaar!; Muhamedi kõnelus mäega ja mäe kõnelus Muhamediga; Täna kõikk on kurvad; Poeedi ohkamine; Noa ja plaanidega mitte sobivad ilmastikumuutused; Kaks ekspressi; Vahel

  14. Polymeric flat focal field arrayed waveguide grating using electron-beam direct writing

    Science.gov (United States)

    Lu, Si; Yan, Yingbai; Jin, Guofan; Wong, W. H.; Pun, E. Y. B.

    2004-06-01

    A four-channel 400-GHz spacing flat focal field arrayed waveguide grating (AWG) demultiplexer is designed based on polymeric optical waveguide. The waveguide core-layer material is a newly developed negative tone epoxy Novolak resin (ENR) polymer with ultravoilet (UV) cured resin Norland optical adhesive 61 (NOA61) as the cladding layer. The device is fabricated using electron-beam direct writing, which has less processing steps than the reported polymeric AWGs. The experimental result is presented.

  15. Mongolian Rotifers on Micr oscope Slides: Instructions to Permanent Specimen Mounts from Expedition Material

    OpenAIRE

    Christian D. Jersabek; Erdene Bolortsetseg; Howard L. Taylor

    2010-01-01

    We here describe a method for permanently mounting specimens on microscope slides, as we applied it in the newly established rotifer collection in Ulaanbaatar, Mongolia. The liquid photopolymer NOA 61 was used as a primary sealant for pure glycerine mounts. We furthermore outline simple methods of rotifer narcotization and fi xation in the fi eld that yield, for the majority of species, adequately preserved specimen mat...

  16. Distinguishing non-obstructive azoospermia from obstructive azoospermia in Taiwanese patients by hormone profile and testis size

    Directory of Open Access Journals (Sweden)

    I-Shen Huang

    2018-06-01

    Full Text Available Background: An accurate diagnosis of the etiology of azoospermia is crucial, as sperm retrieval methods differ between patients with non-obstructive azoospermia (NOA and obstructive azoospermia (OA. The aim of this study was to determine hormone and testes size cutoff values to identify the cause of azoospermia in Taiwanese patients. Methods: The medical records of azoospermic patients were retrospectively collected from April 2008 to July 2016, including hormone profile, physical examination findings, and testes size. Bilateral testes biopsies or microdissection testicular sperm extraction were performed in all patients for a definite diagnosis. The diagnostic parameters used to distinguish NOA from OA were analyzed using the t-test and receiver operating characteristic curves. Results: A total of 51 patients with OA and 156 with NOA were included. The mean levels of testosterone (4.5 vs. 3.4 ng/ml and E2 (26.3 vs. 19.2 pg/ml were significantly higher in the OA group, whereas the levels of follicular stimulating hormone (FSH (5.6 vs. 25.4 mIU/ml and Leutinizing hormone (LH (3.7 vs. 11.6 mIU/ml were lower. Receiver operating characteristic curve analysis revealed that FSH and right testis size were the best individual diagnostic predictors. Using a combination of FSH >9.2 mIU/ml and right testis size 9.2 mIU/ml and right testis size <15 ml was a strong predictor of NOA in our Taiwanese patients. Keywords: Azoospermia, FSH, Hormone, Testis

  17. Relationship between macular thickness measurement and signal strength using Stratus optical coherence tomography

    OpenAIRE

    Segal, Ori; Shapira, Yinon; Gershoni, Assaf; Vainer, Igor; Nemet, Arie Y; Geffen, Noa; Mimouni, Michael

    2016-01-01

    Ori Segal,1 Yinon Shapira,2 Assaf Gershoni,1 Igor Vainer,2 Arie Y Nemet,1 Noa Geffen,1 Michael Mimouni2 1Department of Ophthalmology, Meir Medical Center, Kfar Saba, Israel and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, 2Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel Purpose: To examine the relationship between signal strength and macular thickness as measured by Stratus optical coherence tomography (OCT)’s fast macular thickness protocol...

  18. Wafer-scale fabrication of glass-FEP-glass microfluidic devices for lipid bilayer experiments.

    Science.gov (United States)

    Bomer, Johan G; Prokofyev, Alexander V; van den Berg, Albert; Le Gac, Séverine

    2014-12-07

    We report a wafer-scale fabrication process for the production of glass-FEP-glass microdevices using UV-curable adhesive (NOA81) as gluing material, which is applied using a novel "spin & roll" approach. Devices are characterized for the uniformity of the gluing layer, presence of glue in the microchannels, and alignment precision. Experiments on lipid bilayers with electrophysiological recordings using a model pore-forming polypeptide are demonstrated.

  19. SERS Nanosensors for in Vivo Glucose Sensing

    Science.gov (United States)

    2017-09-01

    laser beam. All data were processed using GRAMS/AI 7.0 (Thermo Galactic, Salem, NH). UV −Vis Spectroscopy. Scattering spectra (400−900 nm) were...Norland Optical Adhesive) is a generic name for commercially available one-part adhesive liquids that can be cured under UV light exposure at room...molds with NOA, removing air bubbles by gentle vacuum, and curing the polymer by UV exposure. The solidified array is then removed from the mold

  20. Building Infrastructure to Accelerate Transfer of Basic Research in Spinal Cord Injury (SCI) to Clinical Practice: North American Clinical Trials Network

    Science.gov (United States)

    2013-08-01

    that may emerge and longer term lifestyle and caregiving issues). A recent Lancet publication (Freund et al) reports on the use of MRI to track the...hours of injury. Riluzole, 50 mg, was administered enterally ( tablet form) every 12 hours for 14 days. At the successful conclusion of the Riluzole...report. • Michael Fehlings, MD, PhD, University Health Network (University of Toronto) (NOA5-2011-MF) for “The use of MRI characteristics to predict

  1. The predictive value of parameters of clinical presentations for sperm yield in patients with nonobstructive azoospermia receiving microdissection testicular sperm extraction

    Directory of Open Access Journals (Sweden)

    Ming-Hsuan Ku

    2017-12-01

    Conclusion: Clinical presentations or phenotypes can be used as predictive factors for successful sperm retrieval during mTESE in patients with NOA. Hypogonadotropic hypogonadism and cases with UDT history have a higher chance of sperm retrieval. Initial testicular needle biopsy, if available, can provide valuable information about chances of sperm retrieval. Hypospermatogenesis predicts high sperm yield rate, and LMA can have best upgrade results of sperm yield after mTESE.

  2. Immunomodulatory effects in workers exposed to naturally occurring asbestos fibers.

    Science.gov (United States)

    Ledda, Caterina; Costa, Chiara; Matera, Serena; Puglisi, Beatrice; Costanzo, Valentina; Bracci, Massimo; Fenga, Concettina; Rapisarda, Venerando; Loreto, Carla

    2017-05-01

    Natural asbestiform fibers are defined 'naturally occurring asbestos' (NOA) and refer to the mineral as a natural component of soils or rocks. The release of NOA fibers into the air from rocks or soils by routine human activities or natural weathering processes represents a risk for human beings. Fluoro-edenite (FE) is a NOA fiber detected in the benmoreitic lava in the area of Biancavilla, South-west slope of Mt. Etna. The aim of the present study was to investigate FE immunotoxicity pathways in a group of 38 occupationally exposed construction workers, in order to find any biological markers of its effect. Subjects underwent respiratory function tests and HRCT total chest scanning. Serum IL-1β, IL-6, IL-8 and TNF-α were measured. The presence of PPs was significantly greater in subjects exposed than in the control (25 vs. 2). In subjects exposed to FE, IL-1β and TNF-α values were significantly higher than the controls. The previously observed increase of IL-1β and IL-18 showed a probable involvement of the proteic complex defined inflammosome by FE fibers.

  3. Aporte aborigen y africano de diferentes regiones de la Argentina en Buenos Aires

    Directory of Open Access Journals (Sweden)

    Avena, Sergio Alejandro

    2003-01-01

    Full Text Available En trabajos anteriores realizados en muestras poblacionales de la Región Metropolitana de Buenos Aires (RMBA hemos observado un 15,2 % de aporte indígena (AI y un 3,8% de africano (AA. En el presente estudio se analizó una muestra de 169 individuos provenientes de las regiones del noroeste (NOA, del nordeste (NEA y del centro del país (CP, se excluye la RMBA que fueron donantes en el Banco de Sangre de la Provincia de Buenos Aires. Esta muestra se adicionó a las previamente obtenidas de las mismas regiones en los hospitales de Clínicas e Italiano. El objetivo fue evaluar si existe una distribución diferencial del AI y el AA según la región de origen de los dadores. Para ello se determinaron los sistemas ABO, Rh, MNS, Diego, Duffy, Gm y Km. Las frecuencias génicas y haplotípicas fueron calculadas mediante métodos de máxima verosimilitud y la mezcla génica se calculó aplicando el programa ADMIX. La región con mayor AI fue NOA (49,5% seguida por NEA (28,4% y CP (17,2%, mientras que el AA fue similar en las tres regiones (NOA 3,2%, NEA 3,5% y CP 3,8.

  4. UNPUBLISHED TEXTS / INEDITI

    African Journals Online (AJOL)

    User

    È come una fetta di luna. L'nguria che assaggi e che sputi non ti puoi saziare come del mare e dell'aria e dei pini marittimi e di questa quercia alberi dal tronco di sughero che è facile strappare, corteccia che ricresce. Non ti puoi saziare di questo mare verde e profondo luminosa acqua pietre pesci coralli gusci di perle.

  5. The Genome Atlas Resource

    DEFF Research Database (Denmark)

    Azam Qureshi, Matloob; Rotenberg, Eva; Stærfeldt, Hans Henrik

    2010-01-01

    with scripts and algorithms developed in a variety of programming languages at the Centre for Biological Sequence Analysis in order to create a three-tier software application for genome analysis. The results are made available via a web interface developed in Java, PHP and Perl CGI. User...

  6. t{f, tjse of dpw at varying levels tn cattle fattening rations

    African Journals Online (AJOL)

    As gevolgvan die laer rantsoenkoste was die insluiting van DHM. in plaas van sonneblomoliekoekmecl, selfs tct by die l2/, perl van inskakeling teen heersendepryseekodmies geregverdig". SUMMARY. ..... performance, the saving in ration costs is such that even at the l2/' level of inclusion, the use of DPW at R40/ ton is still ...

  7. Sharing Programming Resources Between Bio* Projects Through Remote Procedure Call and Native Call Stack Strategies

    NARCIS (Netherlands)

    Prins, J.C.P.; Goto, N.; Yates, A.; Gautier, L.; Willis, S.; Fields, C.; Katayama, T.

    2012-01-01

    Open-source software (OSS) encourages computer programmers to reuse software components written by others. In evolutionary bioinformatics, OSS comes in a broad range of programming languages, including C/C++, Perl, Python, Ruby, Java, and R. To avoid writing the same functionality multiple times for

  8. Discovery of the τ lepton and electron antineutrino awarded the 1995 Nobel Physics Prize

    International Nuclear Information System (INIS)

    Gu Yifan

    1996-01-01

    American physicists Martin Perl and Fredrick Reines shared the 1995 Nobel Prize for physics for the discoveries of two of nature's most remarkable subatomic particles. Their pioneering contributions in lepton physics under-pinned subsequent developments in establishing the present picture of matter at the lepton-quark level

  9. Ultradian rhythm unmasked in the Pdf clock mutant of Drosophila

    Indian Academy of Sciences (India)

    2014-07-20

    Ohtomo et al. .... stand the influence of these two phases, short sampling segments were ... per-long (perL) mutants also showed ultradian rhythms un- der L:L ..... would like to dedicate this paper to the memory of Dr Obaid. Siddiqi.

  10. Associateship | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Period: 2002–2006. Shalivahan, Dr. Date of birth: 10 March 1971. Specialization: Nonlinear Inversion, Electrical & Electromagnetic Methods Address during Associateship: Department of Applied Geophysics, Indian School of Mines, Dhanbad 826 004. Contact: Email: sv@perl.ism.ac.in. YouTube; Twitter; Facebook; Blog ...

  11. Taking the High Ground: A Case for Department of Defense Application of Public Cloud Computing

    Science.gov (United States)

    2011-06-01

    Windows-based servers or LAMP (Linux, Apache, MySQL and PHP ) for Red Hat servers. The server configuration can be customized as needed with up to four CPUs...Linux, Apache, MySQL and Perl preinstalled saving the user a considerable amount of setup time. Often IaaS providers take advantage of the developer

  12. CrossTalk: The Journal of Defense Software Engineering. Volume 23, Number 2, March/April 2010

    Science.gov (United States)

    2010-04-01

    and removing some potential security prob- lems before a program is released. RATS is a tool for scanning C, C++, Perl, PHP , and Python source code, and...BENCHMARK command, which would cause the SQL DB to use 100 percent of the available CPUs. The BENCHMARK command causes MySQL (a relational database

  13. Isozyme variation in lychee (Litchi chinensis Sonn.)

    Science.gov (United States)

    A genetic diversity analysis involving 49 lychee (Litchi chinensis SOM.) accessions using eight enzyme systems encoding 12 loci (Zdh-I, Zdh-2, Mdh-2, Per-l, Pgi-2, Pgm-1, Pgm-2, Sk& Tpi-1, Tpi-2, Ugpp-1, and Ugpp-2) revealed moderate to high levels of genetic variability. Cluster analysis of the iso...

  14. Relentless Verity: Education for Being-Becoming-Belonging.

    Science.gov (United States)

    Kidd, James Robbins

    The dynamic relationship of the concepts of being, becoming, and belonging is and must be the heart and central goal of adult education. The concept can be understood most readily by examination of the writings of humanist psychologists such as Carl Rogers, Fritz Perls, Gordon Allport, and Abraham Maslow. Some characteristics or dimensions of an…

  15. A comparison study of histochemical staining of various tissues after ...

    African Journals Online (AJOL)

    mean =5.28) then Carnoy's (mean = 4.00). For Alcian blue and Perl's Prussian blue, the best staining qualities were obtained by Formalin (mean = 4.76 and 5.64 respectively) followed by Carnoy's (mean = 2.88 and 3.92 respectively).

  16. Looking for One's Shadow at Noon: Vol. II. Finding the Self in School and Community.

    Science.gov (United States)

    Leue, Mary M.

    This volume contains a collection of essays, reflections, and other writings (many of which originally appeared in several journals) on the relations among self and school and community. The first selection is an obituary of Fritz Perls, a leader of Gestalt therapy. The second essay, "A Social and Political Reassessment of the Work of Wilhelm…

  17. Person-Centered Gestalt Therapy: A Synthesis.

    Science.gov (United States)

    Herlihy, Barbara

    1985-01-01

    Highlights the similarities between the person-centered approach to counseling of Carl Rogers and the Gestalt therapy of Fritz Perls. Discusses implementation of the two approaches and suggests they may be synthesized into a person-centered Gestalt therapy. (MCF)

  18. Author Details

    African Journals Online (AJOL)

    Elaboration de panneaux de particules de bois de kenaf avec un liant non conventionnel : experimentation de la colle d'os en perles. Abstract · Vol 17, No 3 (2015) - Articles Residus de pesticides organochlores retrouves dans quelques poissons du Lac Togo et evaluation du potentiel de risque pour le consommateur

  19. MOCASSIN-prot software

    Science.gov (United States)

    MOCASSIN-prot is a software, implemented in Perl and Matlab, for constructing protein similarity networks to classify proteins. Both domain composition and quantitative sequence similarity information are utilized in constructing the directed protein similarity networks. For each reference protein i...

  20. Data Analysis Details (DS): SE53_DS02 [Metabolonote[Archive

    Lifescience Database Archive (English)

    Full Text Available of NetCDF data files, the data matrix was generated using the MetAlign software(De Vos et al., 2007). By usi... matrices were processed using in-house software written in Perl/Tk. The original peak intensity values were

  1. Advantages of Application of Electronic Commerce in Procurement for the Armed Forces of Brazil and South Korea

    Science.gov (United States)

    2001-12-01

    Northern Europe.”, Ecommerce Times, [http://www.ecommercetimes.com/perl/story/3546.html], June 2001. Mc Gregor, Don, “Encryption”, [http...sans.org/infosecFAQ/ ecommerce /fraud.htm], September 2001. Schneider, Gary P. and James T. Perry, “Electronic Commerce”, Course Technology, 2001

  2. Uddannelse i målerlarvens tid

    DEFF Research Database (Denmark)

    Staugaard, Hans Jørgen

    2014-01-01

    særlig styrelse for målinger, nemlig Kvalitets- og Tilsynsstyrelsen. Denne styrelse har som central opgave at forvalte den danske del af de internationale målinger som PISA, TALIS, ICCS, TIMSS, PERLS og ICILS . Et aktuelt initiativ fra Kvalitets- og Tilsynsstyrelsen er en omfattende kategorisering og...

  3. Web-Based Search and Plot System for Nuclear Reaction Data

    International Nuclear Information System (INIS)

    Otuka, N.; Nakagawa, T.; Fukahori, T.; Katakura, J.; Aikawa, M.; Suda, T.; Naito, K.; Korennov, S.; Arai, K.; Noto, H.; Ohnishi, A.; Kato, K.

    2005-01-01

    A web-based search and plot system for nuclear reaction data has been developed, covering experimental data in EXFOR format and evaluated data in ENDF format. The system is implemented for Linux OS, with Perl and MySQL used for CGI scripts and the database manager, respectively. Two prototypes for experimental and evaluated data are presented

  4. The use of special stains in liver biopsy interpretation: Implications ...

    African Journals Online (AJOL)

    Materials and Methods: The formalin fixed paraffin embedded blocks of liver biopsies reported in two histopathology laboratories between 2008 and 2013 were retrieved. These were stained with H and E and the following standard special stains for liver tissue histology – Perl's Prussian blue, reticulin, Sirius red, Shikata ...

  5. CERN Technical Training 2006: Software and System Technologies Curriculum - Scheduled Course Sessions (August-December 2006)

    CERN Multimedia

    2006-01-01

    The Software and System Technologies Curriculum of the CERN Technical Training Programme offers comprehensive training in C++, Java, Perl, Python, XML, OO programming, JCOP/PVSS, database design and Oracle. In the PERL, C++, OO and Java course series there are some places available on the following course sessions, scheduled until the end of this year: PERL 5 - Introduction: 31.8-1.9.2006 (2 days) C++ for Particle Physicists: 16-20.10.2006 (6 half days, the popular course given by Paul Kunz) Object-Oriented Analysis and Design using UML: 17-19.10.2006 (3 days) JAVA 2 Enterprise Edition - Part 1: Web Applications: 19-20.10.2006 (2 days) JAVA - Level 1: 30.10-1.11.2006 (3 days) PERL 5 - Advanced Aspects: 2.11.2006 (1 day) C++ Programming Part 1 - Introduction to Object-Oriented Design and Programming: 14-16.11.2006 (3 days) JAVA - Level 2: 4-7.12.2006 (4 days) C++ Programming Part 2 - Advanced C++ and its Traps and Pitfalls: 12-15.12.2006 (4 days) JAVA 2 Enterprise Edition - Part 2: Enterprise JavaBea...

  6. The Live Coding of Slub - Art Oriented Programming as Media Critique

    DEFF Research Database (Denmark)

    Andersen, Christian Ulrik

    2007-01-01

    Computer art is often associated with computer-generated expressions (digital audio/images in music, video, stage design, etc.). In recent computer art, however, the code-text itself – not the generated output – has become the artwork (Perl Poetry, ASCII Art, obfuscated code, etc.). This paper wi...

  7. A resource for benchmarking the usefulness of protein structure models.

    KAUST Repository

    Carbajo, Daniel

    2012-08-02

    BACKGROUND: Increasingly, biologists and biochemists use computational tools to design experiments to probe the function of proteins and/or to engineer them for a variety of different purposes. The most effective strategies rely on the knowledge of the three-dimensional structure of the protein of interest. However it is often the case that an experimental structure is not available and that models of different quality are used instead. On the other hand, the relationship between the quality of a model and its appropriate use is not easy to derive in general, and so far it has been analyzed in detail only for specific application. RESULTS: This paper describes a database and related software tools that allow testing of a given structure based method on models of a protein representing different levels of accuracy. The comparison of the results of a computational experiment on the experimental structure and on a set of its decoy models will allow developers and users to assess which is the specific threshold of accuracy required to perform the task effectively. CONCLUSIONS: The ModelDB server automatically builds decoy models of different accuracy for a given protein of known structure and provides a set of useful tools for their analysis. Pre-computed data for a non-redundant set of deposited protein structures are available for analysis and download in the ModelDB database. IMPLEMENTATION, AVAILABILITY AND REQUIREMENTS: Project name: A resource for benchmarking the usefulness of protein structure models. Project home page: http://bl210.caspur.it/MODEL-DB/MODEL-DB_web/MODindex.php.Operating system(s): Platform independent. Programming language: Perl-BioPerl (program); mySQL, Perl DBI and DBD modules (database); php, JavaScript, Jmol scripting (web server). Other requirements: Java Runtime Environment v1.4 or later, Perl, BioPerl, CPAN modules, HHsearch, Modeller, LGA, NCBI Blast package, DSSP, Speedfill (Surfnet) and PSAIA. License: Free. Any restrictions to use by

  8. A resource for benchmarking the usefulness of protein structure models.

    Science.gov (United States)

    Carbajo, Daniel; Tramontano, Anna

    2012-08-02

    Increasingly, biologists and biochemists use computational tools to design experiments to probe the function of proteins and/or to engineer them for a variety of different purposes. The most effective strategies rely on the knowledge of the three-dimensional structure of the protein of interest. However it is often the case that an experimental structure is not available and that models of different quality are used instead. On the other hand, the relationship between the quality of a model and its appropriate use is not easy to derive in general, and so far it has been analyzed in detail only for specific application. This paper describes a database and related software tools that allow testing of a given structure based method on models of a protein representing different levels of accuracy. The comparison of the results of a computational experiment on the experimental structure and on a set of its decoy models will allow developers and users to assess which is the specific threshold of accuracy required to perform the task effectively. The ModelDB server automatically builds decoy models of different accuracy for a given protein of known structure and provides a set of useful tools for their analysis. Pre-computed data for a non-redundant set of deposited protein structures are available for analysis and download in the ModelDB database. IMPLEMENTATION, AVAILABILITY AND REQUIREMENTS: Project name: A resource for benchmarking the usefulness of protein structure models. Project home page: http://bl210.caspur.it/MODEL-DB/MODEL-DB_web/MODindex.php.Operating system(s): Platform independent. Programming language: Perl-BioPerl (program); mySQL, Perl DBI and DBD modules (database); php, JavaScript, Jmol scripting (web server). Other requirements: Java Runtime Environment v1.4 or later, Perl, BioPerl, CPAN modules, HHsearch, Modeller, LGA, NCBI Blast package, DSSP, Speedfill (Surfnet) and PSAIA. License: Free. Any restrictions to use by non-academics: No.

  9. FAST: FAST Analysis of Sequences Toolbox

    Directory of Open Access Journals (Sweden)

    Travis J. Lawrence

    2015-05-01

    Full Text Available FAST (FAST Analysis of Sequences Toolbox provides simple, powerful open source command-line tools to filter, transform, annotate and analyze biological sequence data. Modeled after the GNU (GNU’s Not Unix Textutils such as grep, cut, and tr, FAST tools such as fasgrep, fascut, and fastr make it easy to rapidly prototype expressive bioinformatic workflows in a compact and generic command vocabulary. Compact combinatorial encoding of data workflows with FAST commands can simplify the documentation and reproducibility of bioinformatic protocols, supporting better transparency in biological data science. Interface self-consistency and conformity with conventions of GNU, Matlab, Perl, BioPerl, R and GenBank help make FAST easy and rewarding to learn. FAST automates numerical, taxonomic, and text-based sorting, selection and transformation of sequence records and alignment sites based on content, index ranges, descriptive tags, annotated features, and in-line calculated analytics, including composition and codon usage. Automated content- and feature-based extraction of sites and support for molecular population genetic statistics makes FAST useful for molecular evolutionary analysis. FAST is portable, easy to install and secure thanks to the relative maturity of its Perl and BioPerl foundations, with stable releases posted to CPAN. Development as well as a publicly accessible Cookbook and Wiki are available on the FAST GitHub repository at https://github.com/tlawrence3/FAST. The default data exchange format in FAST is Multi-FastA (specifically, a restriction of BioPerl FastA format. Sanger and Illumina 1.8+ FastQ formatted files are also supported. FAST makes it easier for non-programmer biologists to interactively investigate and control biological data at the speed of thought.

  10. A resource for benchmarking the usefulness of protein structure models.

    KAUST Repository

    Carbajo, Daniel; Tramontano, Anna

    2012-01-01

    BACKGROUND: Increasingly, biologists and biochemists use computational tools to design experiments to probe the function of proteins and/or to engineer them for a variety of different purposes. The most effective strategies rely on the knowledge of the three-dimensional structure of the protein of interest. However it is often the case that an experimental structure is not available and that models of different quality are used instead. On the other hand, the relationship between the quality of a model and its appropriate use is not easy to derive in general, and so far it has been analyzed in detail only for specific application. RESULTS: This paper describes a database and related software tools that allow testing of a given structure based method on models of a protein representing different levels of accuracy. The comparison of the results of a computational experiment on the experimental structure and on a set of its decoy models will allow developers and users to assess which is the specific threshold of accuracy required to perform the task effectively. CONCLUSIONS: The ModelDB server automatically builds decoy models of different accuracy for a given protein of known structure and provides a set of useful tools for their analysis. Pre-computed data for a non-redundant set of deposited protein structures are available for analysis and download in the ModelDB database. IMPLEMENTATION, AVAILABILITY AND REQUIREMENTS: Project name: A resource for benchmarking the usefulness of protein structure models. Project home page: http://bl210.caspur.it/MODEL-DB/MODEL-DB_web/MODindex.php.Operating system(s): Platform independent. Programming language: Perl-BioPerl (program); mySQL, Perl DBI and DBD modules (database); php, JavaScript, Jmol scripting (web server). Other requirements: Java Runtime Environment v1.4 or later, Perl, BioPerl, CPAN modules, HHsearch, Modeller, LGA, NCBI Blast package, DSSP, Speedfill (Surfnet) and PSAIA. License: Free. Any restrictions to use by

  11. HGF and BFGF Secretion by Human Adipose-Derived Stem Cells Improves Ovarian Function During Natural Aging via Activation of the SIRT1/FOXO1 Signaling Pathway.

    Science.gov (United States)

    Ding, Chenyue; Zou, Qinyan; Wang, Fuxin; Wu, Huihua; Wang, Wei; Li, Hong; Huang, Boxian

    2018-01-01

    Human adipose-derived stem cells (hADSCs) are a potential therapeutic option for clinical applications because of their ability to produce cytokines and their capacity for trilineage differentiation. To date, few researchers have investigated the effects of hADSCs on natural ovarian aging (NOA). An NOA mouse model and human ovarian granule cells (hGCs) collected from individuals with NOA were prepared to assess the therapeutic effects and illuminate the mechanism of hADSCs in curing NOA. Enzyme-linked immunosorbent assay was used to detect the serum levels of sex hormones and antioxidative enzymes. The proliferation rate and marker expression level of hGCs were measured by flow cytometry (FACS). Cytokines were measured by a protein antibody array methodology. Western blot assays were used to determine the protein expression levels of SIRT1 and FOXO1. Our results showed that hADSCs displayed therapeutic activity against ovarian function in an NOA mouse model, increasing the proliferation rate and marker expression level of hGCs. Furthermore, the yields of hADSC-secreted HGF and bFGF were higher than those of other growth factors. FACS showed that combination treatment with the growth factors HGF and bFGF more strongly promoted proliferation and inhibited apoptosis in hGCs than HGF or bFGF treatment alone. FACS and ELISA revealed that the combination treatment with both growth factors inhibited oxidative stress more forcefully than treatments with only one of these growth factors. In addition, protein assays demonstrated that combination treatment with both growth factors suppressed oxidative stress by up-regulating the expression of SIRT1 and FOXO1. These findings demonstrate for the first time the molecular cascade and related cell biology events involved in the mechanism by which HGF and bFGF derived from hADSCs improved ovarian function during natural aging via reduction of oxidative stress by activating the SIRT1/FOXO1 signaling pathway. © 2018 The Author

  12. Outcome of varicocele repair in men with nonobstructive azoospermia: systematic review and meta-analysis

    Directory of Open Access Journals (Sweden)

    Sandro C Esteves

    2016-01-01

    Full Text Available The objective of this systemic review was to evaluate the benefit of repairing clinical varicocele in infertile men with nonobstructive azoospermia (NOA. The surgically obtained sperm retrieval rate (SRR and pregnancy rates following assisted reproductive technology (ART with the use of retrieved testicular sperm were the primary outcomes. The secondary outcomes included the presence of viable sperm in postoperative ejaculate to avoid the testicular sperm retrieval and pregnancy rates (both assisted and unassisted using postoperative ejaculated sperm. An electronic search to collect the data was performed using the MEDLINE and EMBASE databases until April 2015. Eighteen studies were included in this systematic review and accounted for 468 patients who were diagnosed with NOA and varicocele. These patients were subjected to either surgical varicocele repair or percutaneous embolization. Three controlled studies evaluating sperm retrieval outcomes indicated that in patients who underwent varicocelectomy, SRR increased compared to those without varicocele repair (OR: 2.65; 95% CI: 1.69-4.14; P< 0.001. Although pregnancy rates with the use of testicular sperm favored the varicocelectomy group, results were not statistically significant (clinical pregnancy rate OR: 2.07; 95% CI: 0.92-4.65; P= 0.08; live birth rate OR: 2.19; 95% CI: 0.99-4.83; P= 0.05. The remaining fifteen studies reported postoperative semen analysis results. In 43.9% of the patients (range: 20.8%-55.0%, sperm were found in postoperative ejaculates. Pregnancy rates for unassisted and assisted (after IVF/ICSI were 13.6% and 18.9% in the group of men with sperm in postoperative ejaculates, respectively. Our findings indicate that varicocelectomy in patients with NOA and clinical varicocele is associated with improved SRR. In addition, approximately 44% of the treated men will have enough sperm in the ejaculate to avoid sperm retrieval. Limited data on pregnancy outcomes with both

  13. Evaluation of the varying Naturally Occurring Asbestos mitigation measures at School and Commercial construction projects in California

    Science.gov (United States)

    Kalika, S.

    2012-12-01

    In commercial development or K-12 school construction, project sites are often purchased and much of the planning process completed prior to an assessment of the soils proposed for excavation or potential offhaul. Geologic maps, while initially helpful for identifying potential hazards such as landslides and earthquake faults, are less helpful in the identification of naturally occurring hazardous minerals, such as the seven regulated minerals currently classified as asbestos. Geologic maps identify mafic and ultramafic bedrock zones; however, a skilled geologist with knowledge of asbestos hazards will further visualize the earth-shaping processes that may have resulted in the deposition of naturally occurring asbestos in locations outside mapped ultramafic zones including the base of an alluvial fan or within streambed channels. When sampled as an afterthought prior to disposal, property owners are surprised by the budget-crippling costs of waste handling and disposal of NOA, as well as mitigations required to protect the health of construction workers, the public, and future site occupants. The California Air Resources Board (CARB) continues to lead the way in evaluation and regulation of NOA, through development of the CARB 435 preparation and laboratory analytical method, local enforcement of the Asbestos Airborne Toxic Control Measure for Construction, Grading, Quarrying, and Surface Mining Operations (ATCM), and implementation of dust control measures to protect public health. A thorough site evaluation and construction design includes utilization of the sampling methods developed by the California Geological Survey, laboratory analytical methods within CARB 435, and mitigation measures required by CARB, DTSC, and OSHA for the protection of worker and public health after NOA is discovered. The site evaluation should additionally include an assessment of the future site usage, as regulations differ based on potential health affects to future occupants

  14. Couples with non-obstructive azoospermia are interested in future treatments with artificial gametes.

    Science.gov (United States)

    Hendriks, S; Hessel, M; Mochtar, M H; Meissner, A; van der Veen, F; Repping, S; Dancet, E A F

    2016-08-01

    Would couples diagnosed with non-obstructive azoospermia (NOA) consider two future treatments with artificial gametes (AGs) as alternatives for testicular sperm extraction followed by ICSI (TESE-ICSI)? Most couples with NOA (89%) would opt for treatment with AGs before attempting TESE-ICSI and/or after failed TESE-ICSI. Couples with NOA who undergo TESE-ICSI have a 25% chance of conceiving a child. Two future treatments that are being developed are 'ICSI with artificial sperm formed from somatic cells' (ICSI with AGs) and 'natural conception after autotransplantation of in vitro proliferated spermatogonial stem cells' (natural conception with AGs). It is unknown what treatment preferences patients have. A cross-sectional survey conducted in 2012-2013, addressing all 921 couples diagnosed with NOA and treated with TESE-ICSI in Dutch fertility clinics between 2007 and 2012. The coded questionnaires were sent by mail and followed up with two reminders. We developed the questionnaire based on a literature review and previous qualitative interviews, and included treatment preference and the valuation of nine treatment characteristics. We assessed reliability of the questionnaires and calculated mean importance scores (MISs: 0-10) of each treatment characteristic. We assessed which patient and treatment characteristics were associated with a couple's hypothetical treatment preference using binominal regression. The vast majority (89%) of the 494 responding couples (response rate: 54%) would potentially opt for AGs as a first and/or a last resort treatment option. More specifically, as a first treatment couples were likely (67%) to prefer natural conception with AGs over TESE-ICSI and less likely to prefer ICSI with AGs over TESE-ICSI (34%). After failed TESE-ICSI, the majority of couples (75%) would want to attempt ICSI with AGs as a last resort option. The most important characteristics of treatment were safety for children (MIS: 8.2), pregnancy rates (MIS: 7.7) and

  15. A night with good vibrations

    CERN Multimedia

    2002-01-01

    Next week-end, the Geneva Science History Museum invites you to a Science Night under the banner of waves and vibrations. Scientists, artists and storytellers from more than forty institutes and local or regional associations will show that waves and vibrations form an integral part of our environment. You will be able to get in contact with the nature of waves through interactive exhibitions on sound and light and through hands-on demonstrations arranged in the Park of the Perle du Lac. On the CERN stand, you will be able to measure the speed of light with a bar of chocolate, and understand the scattering of waves with plastic ducks. Amazing, no? In addition to the stands, the Night will offer many other activities: reconstructions of experiments, a play, a concert of crystal glasses, an illuminated fountain, a house of spirits. More information Science Night, 6 and 7 July, Park of the Perle du Lac, Geneva

  16. Speech-rhythm characteristics of client-centered, Gestalt, and rational-emotive therapy interviews.

    Science.gov (United States)

    Chen, C L

    1981-07-01

    The aim of this study was to discover whether client-centered, Gestalt, and rational-emotive psychotherapy interviews could be described and differentiated on the basis of quantitative measurement of their speech rhythms. These measures were taken from the sound portion of a film showing interviews by Carl Rogers, Frederick Perls, and Albert Ellis. The variables used were total session and percentage of speaking times, speaking turns, vocalizations, interruptions, inside and switching pauses, and speaking rates. The three types of interview had very distinctive patterns of speech-rhythm variables. These patterns suggested that Rogers's Client-centered therapy interview was patient dominated, that Ellis's rational-emotive therapy interview was therapist dominated, and that Perls's Gestalt therapy interview was neither therapist nor patient dominated.

  17. Sharing programming resources between Bio* projects through remote procedure call and native call stack strategies

    DEFF Research Database (Denmark)

    Prins, Pjotr; Goto, Naohisa; Yates, Andrew

    2012-01-01

    Open-source software (OSS) encourages computer programmers to reuse software components written by others. In evolutionary bioinformatics, OSS comes in a broad range of programming languages, including C/C++, Perl, Python, Ruby, Java, and R. To avoid writing the same functionality multiple times...... for different languages, it is possible to share components by bridging computer languages and Bio* projects, such as BioPerl, Biopython, BioRuby, BioJava, and R/Bioconductor. In this chapter, we compare the two principal approaches for sharing software between different programming languages: either by remote...... procedure call (RPC) or by sharing a local call stack. RPC provides a language-independent protocol over a network interface; examples are RSOAP and Rserve. The local call stack provides a between-language mapping not over the network interface, but directly in computer memory; examples are R bindings, RPy...

  18. CBS Genome Atlas Database: a dynamic storage for bioinformatic results and sequence data

    DEFF Research Database (Denmark)

    Hallin, Peter Fischer; Ussery, David

    2004-01-01

    , these results counts to more than 220 pieces of information. The backbone of this solution consists of a program package written in Perl, which enables administrators to synchronize and update the database content. The MySQL database has been connected to the CBS web-server via PHP4, to present a dynamic web...... and frequent addition of new models are factors that require a dynamic database layout. Using basic tools like the GNU Make system, csh, Perl and MySQL, we have created a flexible database environment for storing and maintaining such results for a collection of complete microbial genomes. Currently...... content for users outside the center. This solution is tightly fitted to existing server infrastructure and the solutions proposed here can perhaps serve as a template for other research groups to solve database issues....

  19. A Ruby API to query the Ensembl database for genomic features.

    Science.gov (United States)

    Strozzi, Francesco; Aerts, Jan

    2011-04-01

    The Ensembl database makes genomic features available via its Genome Browser. It is also possible to access the underlying data through a Perl API for advanced querying. We have developed a full-featured Ruby API to the Ensembl databases, providing the same functionality as the Perl interface with additional features. A single Ruby API is used to access different releases of the Ensembl databases and is also able to query multi-species databases. Most functionality of the API is provided using the ActiveRecord pattern. The library depends on introspection to make it release independent. The API is available through the Rubygem system and can be installed with the command gem install ruby-ensembl-api.

  20. Multifunctional microstructured polymer films for boosting solar power generation of silicon-based photovoltaic modules.

    Science.gov (United States)

    Leem, Jung Woo; Choi, Minkyu; Yu, Jae Su

    2015-02-04

    We propose two-dimensional periodic conical micrograting structured (MGS) polymer films as a multifunctional layer (i.e., light harvesting and self-cleaning) at the surface of outer polyethylene terephthalate (PET) cover-substrates for boosting the solar power generation in silicon (Si)-based photovoltaic (PV) modules. The surface of ultraviolet-curable NOA63 MGS polymer films fabricated by the soft imprint lithography exhibits a hydrophobic property with water contact angle of ∼121° at no inclination and dynamic advancing/receding water contact angles of ∼132°/111° at the inclination angle of 40°, respectively, which can remove dust particles or contaminants on the surface of PV modules in real outdoor environments (i.e., self-cleaning). The NOA63 MGS film coated on the bare PET leads to the reduction of reflection as well as the enhancement of both the total and diffuse transmissions at wavelengths of 300-1100 nm, indicating lower solar weighted reflectance (RSW) of ∼8.2%, higher solar weighted transmittance (TSW) of ∼93.1%, and considerably improved average haze ratio (HAvg) of ∼88.3% as compared to the bare PET (i.e., RSW ≈ 13.5%, TSW ≈ 86.9%, and HAvg ≈ 9.1%), respectively. Additionally, it shows a relatively good durability at temperatures of ≤160 °C. The resulting Si PV module with the NOA63 MGS/PET has an enhanced power conversion efficiency (PCE) of 13.26% (cf., PCE = 12.55% for the reference PV module with the bare PET) due to the mainly improved short circuit current from 49.35 to 52.01 mA, exhibiting the PCE increment percentage of ∼5.7%. For light incident angle-dependent PV module current-voltage characteristics, superior solar energy conversion properties are also obtained in a broad angle range of 10-80°.

  1. All-polymeric sensing platform based on packaged self-assembled bottle microresonator (Conference Presentation)

    Science.gov (United States)

    Bernini, Romeo; Grimaldi, Immacolata A.; Persichetti, Gianluca; Testa, Genni

    2017-02-01

    In recent years, microbottle resonators that support non-degenerate whispering gallery modes (WGMs), propagating by successive total internal reflections close to the resonator surface and all along its axis, have been widely investigated due to their potential applications in optical sensing, microlasers and nonlinear optics. To overcome some drawbacks of the standard silica microbottle resonators, we focused our attention on polymers such as SU-8 resist and NOA resins. A drop of polymeric material is dispensed onto a fiber stem, providing a mechanical support for the bottle resonator, and is photo-polymerized by an UV lamp. The interrogation system, usually constituted by a tapered silica fiber evanescently coupled with the microresonator, is substituted by a more stable planar waveguide realized in SU-8 by means of standard photolithography technique. Moreover, for guarantying the stability to surrounding disturbance of the coupling between the microbottle resonator and the planar waveguide, the fiber stem is glued to substrate. Two drilled holes in the substrate allow the rise of the glue at the ends of the fiber stem and the fixing of sensor on PMMA substrate. In the present work, we presented an integrated full polymeric platform with self-assembled bottle microresonators packaged in a stable structure. SU-8 and NOA based microbottles are realized and morphologically characterized. The low autofluorescence emission and long term stability make the NOA based bottles suitable to be employed in a great variety of conditions. Bulk sensing measurements are performed by using water:ethanol solutions and a bulk sensitivity of 120 nm/RIU is estimated.

  2. An Airlift Hub-and-Spoke Location-Routing Model with Time Windows: Case Study of the CONUS-to-Korea Airlift Problem

    Science.gov (United States)

    1998-03-01

    a point of embarkation to a point of debarkation. This study develops an alternative hub-and-spoke combined location-routing integer linear...programming prototype model, and uses this model to determine what advantages a hub-and-spoke system offers, and in which scenarios it is better-suited than the...extension on the following works: the hierarchical model of Perl and Daskin (1983), time windows features of Chan (1991), combining subtour-breaking and range

  3. Sample Scripts for Generating PaGE-OM XML [

    Lifescience Database Archive (English)

    Full Text Available Sample Scripts for Generating PaGE-OM XML This page is offering some sample scripts...on MySQL. Outline chart of procedure 6. Creating RDB tables for Generating PaGE-OM XML These scripts help yo...wnload: create_tables_sql2.zip 7. Generating PaGE-OM XML from phenotype data This sample Perl script helps y

  4. Study of Tools for Network Discovery and Network Mapping

    Science.gov (United States)

    2003-11-01

    connected to the switch. iv. Accessibility of historical data and event data In general, network discovery tools keep a history of the collected...has the following software dependencies: - Java Virtual machine 76 - Perl modules - RRD Tool - TomCat - PostgreSQL STRENGTHS AND...systems - provide a simple view of the current network status - generate alarms on status change - generate history of status change VISUAL MAP

  5. FloCon 2011 Proceedings

    Science.gov (United States)

    2011-01-01

    particular point in time I Footprint count of all unique individuals across the entire history What’s an “individual”? I Often count and report IP...observed machines cumulative across the recorded active history . A naive measurement of the footprint inflation rate is simply: RN(I ,H) = |I | |H...NfSen plugins architecture recommendations. PHP frontend with a Perl backend and a PostgreSQL DB. Web, e-mail and syslog detection output and reporting

  6. The mediating effect of brand satisfaction on the relationship between brand personality and brand loyalty: Evidence from Malaysia

    OpenAIRE

    Hashed Ahmad Mabkhot; Salniza Md. Salleh; Hasnizam Shaari

    2016-01-01

    This study empirically investigates the mediating effect of brand satisfaction on the relationship between brand personality and brand loyalty among Malaysian customers toward local automobile brands (Proton and Perodua). Four hypotheses were developed to test hypothesizing relationships between brand personality and brand satisfaction on brand loyalty. The data were collected from consumers of automobile brands in north Malaysia peninsula from three states which were Kedah, Penanag, and Perl...

  7. Generation of pharmacophores and classification of drugs using protein-ligand complexes

    Directory of Open Access Journals (Sweden)

    Eliana Velasquez

    2014-04-01

    Full Text Available Pharmacophore identification is a veryimportant step in de novo design, leadoptimization, chemogenomics, and virtualscreening of drugs. Unfortunately,the high cost of comercial software forpharmacophore detection is a commonlimiting factor for researchers with limitedfunding. This paper presents a set offreely available perl routines that weredesigned to help in the process of 3Dpharmacophore identification and QSARstudies. These routines also allowed theclassification of ligands based on theirtridimensional similarity and bindingmechanism. The family of phosphodiesterasesand their inhibitors were used astest model.

  8. Tapir: A web interface for transit/eclipse observability

    Science.gov (United States)

    Jensen, Eric

    2013-06-01

    Tapir is a set of tools, written in Perl, that provides a web interface for showing the observability of periodic astronomical events, such as exoplanet transits or eclipsing binaries. The package provides tools for creating finding charts for each target and airmass plots for each event. The code can access target lists that are stored on-line in a Google spreadsheet or in a local text file.

  9. Introduction to Python for CMF Authority Users

    Energy Technology Data Exchange (ETDEWEB)

    Pritchett-Sheats, Lori A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-03-14

    This talk is a very broad over view of Python that highlights key features in the language used in the Common Model Framework (CMF). I assume that the audience has some programming experience in a shell scripting language (C shell, Bash, PERL) or other high level language (C/C++/ Fortran). The talk will cover Python data types, classes (objects) and basic programming constructs. The talk concludes with slides describing how I developed the basic classes for a TITANS homework assignment.

  10. Playing Detective: Reconstructing Software Architecture from Available Evidence

    Science.gov (United States)

    1997-10-01

    information • PostgreSQL (based on POSTGRES [Stonebraker 90]) for model storage • IAPR [Kazman 96c], RMTool [Murphy 95], and Perl for analysis and...720-741. Stonebraker, M.; Rowe, L; & Hirohama, M. ’The Implementation of POSTGRES ." IEEE Transactions on Knowledge and Data Engineering 2,1 (March...Engineering 19,7 (July 1993): 720-741. Stonebraker, M.; Rowe, L; & Hirohama, M. "The Implementation of POSTGRES ." IEEE Transactions on Knowledge and

  11. Using Scripting Languages to Teach Programming

    OpenAIRE

    Syropoulos, Apostolos; Stavrianos, Athanasios

    2014-01-01

    Nowadays, scripting programming languages like Python, Perl and Ruby are widely used in system programming, scientific computing, etc. Although solving a particular problem in these languages requires less time, less programming effort, and less concepts to be taught to achieve the desired goal, still they are not used as teaching tools. Therefore, the use of scripting languages as a teaching vehicle for programming course is very promising. On the other hand, GUI programming, when performed ...

  12. featsel: A framework for benchmarking of feature selection algorithms and cost functions

    OpenAIRE

    Marcelo S. Reis; Gustavo Estrela; Carlos Eduardo Ferreira; Junior Barrera

    2017-01-01

    In this paper, we introduce featsel, a framework for benchmarking of feature selection algorithms and cost functions. This framework allows the user to deal with the search space as a Boolean lattice and has its core coded in C++ for computational efficiency purposes. Moreover, featsel includes Perl scripts to add new algorithms and/or cost functions, generate random instances, plot graphs and organize results into tables. Besides, this framework already comes with dozens of algorithms and co...

  13. Collecting Virtual Reference Statistics with an IM Chat-Bot

    Directory of Open Access Journals (Sweden)

    Mason R.K. Hall

    2008-06-01

    Full Text Available A perennial problem in libraries is capturing accurate statistics. This article addresses this problem with the creative use of Web 2.0 tools: Meebo and AOL Instant Messenger. It describes the development and implementation of an instant messaging "stat-bot" that prompts staff to record virtual reference statistics via IM. Step-by-step guidelines and the perl script are provided.

  14. Node web development

    CERN Document Server

    Herron, David

    2013-01-01

    Presented in a simple, step-by-step format, this book is an introduction to web development with Node.This book is for anybody looking for an alternative to the ""P"" languages (Perl, PHP, Python), or anyone looking for a new paradigm of server-side application development.The reader should have at least a rudimentary understanding of JavaScript and web application development.

  15. Development of in Vivo Biomarkers for Progressive Tau Pathology after Traumatic Brain Injury

    Science.gov (United States)

    2017-11-01

    Iraqi war veteran with posttraumatic stress disorder who committed suicide . Neurosurgical focus 2011;31:E3. 14. Perl D. Plenary Lecture: Chronic...Washington DC, 2011. 31. Montenigro PH, Alosco ML, Martin BM, et al. Cumulative Head Impact Exposure Predicts Later-Life Depression , Apathy, Executive...anxiety, spatial learning and memory, and depressive behavior. Animals were also assessed for chronic tau pathology, astrogliosis, and white

  16. Ficoflora epilítica y variables ambientales del Arroyo Calimayo (Tucumán-Argentina)

    OpenAIRE

    Taboada, María De Los Ángeles; Gultemirian, María De Lourdes; Martínez De Marco, Silvia N; Tracanna, Beatriz C

    2015-01-01

    Tucumán se destaca por sus riquezas en recursos naturales e hídricos. Los estudios ficológicos se basaron principalmente en el fitoplancton, siendo escaso el análisis de la ficoflora epilítica. Los objetivos fueron analizar la taxocenosis epilítica y variables fisicoquímicas del arroyo durante un ciclo anual y contribuir al conocimiento de la ficoflora del NOA. Se estudiaron muestras fisicoquímicas y biológicas recolectadas durante 2012-2013. El agua tuvo un pH alcalino, se caracterizó como b...

  17. Investigation of 1-D crustal velocity structure beneath Izmir Gulf and surroundings by using local earthquakes

    International Nuclear Information System (INIS)

    Polat, Orhan; Özer, Çaglar

    2016-01-01

    In this study; we examined one dimensional crustal velocity structure of Izmir gulf and surroundings. We used nearly one thousand high quality (A and B class) earthquake data which recorded by Disaster and Emergency Management Presidency (AFAD) [1], Bogazici University (BU-KOERI) [2] and National Observatory of Athens (NOA) [3,4]. We tried several synthetic tests to understand power of new velocity structure, and examined phase residuals, RMS values and shifting tests. After evaluating these tests; we decided one dimensional velocity structure and minimum 1-D P wave velocities, hypocentral parameter and earthquake locations from VELEST algorithm. Distribution of earthquakes was visibly improved by using new minimum velocity structure.

  18. Investigation of 1-D crustal velocity structure beneath Izmir Gulf and surroundings by using local earthquakes

    Energy Technology Data Exchange (ETDEWEB)

    Polat, Orhan, E-mail: orhan.polat@deu.edu.tr [Dokuz Eylul University, Faculty of Engineering, Geophysical Engineering Department, Izmir (Turkey); Özer, Çaglar, E-mail: caglar.ozer@deu.edu.tr [Dokuz Eylul University, Faculty of Engineering, Geophysical Engineering Department, Izmir (Turkey); Dokuz Eylul University, The Graduate School of Natural and Applied Sciences, Department of Geophysical Engineering, Izmir-Turkey (Turkey)

    2016-04-18

    In this study; we examined one dimensional crustal velocity structure of Izmir gulf and surroundings. We used nearly one thousand high quality (A and B class) earthquake data which recorded by Disaster and Emergency Management Presidency (AFAD) [1], Bogazici University (BU-KOERI) [2] and National Observatory of Athens (NOA) [3,4]. We tried several synthetic tests to understand power of new velocity structure, and examined phase residuals, RMS values and shifting tests. After evaluating these tests; we decided one dimensional velocity structure and minimum 1-D P wave velocities, hypocentral parameter and earthquake locations from VELEST algorithm. Distribution of earthquakes was visibly improved by using new minimum velocity structure.

  19. Multiple needle-pass percutaneous testicular sperm aspiration as first-line treatment in azoospermic men

    DEFF Research Database (Denmark)

    Jensen, C F S; Ohl, D A; Hiner, M R

    2016-01-01

    spermatozoa found for intracytoplasmic sperm injection in a subsequent therapeutic TESA. In nine NOA men in whom a TESA produced no spermatozoa, only one had spermatozoa found with mTESE. Overall complication rates of TESA and mTESE were 3% (7/267) and 21% (3/14), respectively. TESA provides reasonable SRR...... and is a safe procedure. Successful prognostic TESA indicates future success with therapeutic TESA. Men with a failed TESA have a limited chance of sperm retrieval using mTESE. Approaching azoospermic men with an initial prognostic TESA followed by either therapeutic TESA and/or mTESE is an efficient algorithm...

  20. Contenido de yodo en sal a nivel de puestos de venta provenientes de distintas localidades en tres regiones argentinas

    OpenAIRE

    López Linares, S; Heer I, Martín

    2014-01-01

    Introducción: La deficiencia de yodo es la principal causa prevenible de retardo mental y daño cerebral en la población. La yodación de la sal en Argentina es obligatoria según Ley 17259/67. El objetivo fue determinar el contenido de yodo en sal obtenida de puestos de venta de distintas localidades de provincias que integran la región del noroeste (NOA), nordeste (NEA) y Cuyo. Material y métodos: Estudio descriptivo y transversal. Se analizaron 80 sales adquiridas por compra directa, mercado ...

  1. High-reflective colorful films fabricated by all-solid multi-layer cholesteric structures

    Science.gov (United States)

    Li, Y.; Luo, D.

    2018-02-01

    We demonstrate all-solid-state film with high-reflectivity based on cholesteric template. The adhesive (NOA81) is both filler and an adhesive, which can be avoids interfacial losses. The reflected right- and left-circularly polarized light has been developed by roll-to-roll method, and the reflectance of the films is more than 78%. Here, the all-solid film was used in distribute feedback laser with dye-doped. In addition, this films also used in include flexible reflective display, color pixels in digital photographs, printing and colored cladding of variety of objects.

  2. In vitro production of haploid cells after coculture of CD49f+ with Sertoli cells from testicular sperm extraction in nonobstructive azoospermic patients.

    Science.gov (United States)

    Riboldi, Marcia; Rubio, Carmen; Pellicer, Antonio; Gil-Salom, Manuel; Simón, Carlos

    2012-09-01

    To isolate CD49f+ cells from testicular sperm extraction (TESE) samples of azoospermic patients and induce meiosis by coculturing these cells with Sertoli cells. Prospective analysis. Research center. Obstructive azoospermic (OA) and nonobstructive azoospermic (NOA) patients. TESE, with enzymatic dissociation of samples to obtain a cell suspension, which was cultured for 4 days with 4 ng/mL GDNF. The CD49f+ cells were sorted using fluorescence-activated cell sorting (FACS) as a marker to identify spermatogonial stem cells (SSCs), which were cocultured with Sertoli cells expressing red fluorescent protein (RFP) in knockout serum replacement (KSR) media with addition of 1,000 IU/mL of follicle-stimulating hormone (FSH), 1 μM testosterone, 40 ng/mL of GDNF, and 2 μM retinoic acid (RA) for 15 days in culture at 37°C and 5% CO(2) to induce meiotic progression. Cells were collected and analyzed by immunofluorescence for meiosis progression with specific markers SCP3 and CREST, and they were confirmed by fluorescence in situ hybridization (FISH). Isolation of CD49f+ cells and coculture with Sertoli cells, meiosis progression in vitro, assessment of SSCs and meiotic markers real-time polymerase chain reaction (RT-PCR), immunohistochemical analysis, and FISH. The CD49f+ isolated from the of total cell count in the TESE samples of azoospermic patients varied from 5.45% in OA to 2.36% in NOA. Sertoli cells were obtained from the same TESE samples, and established protocols were used to characterize them as positive for SCF, rGDNF, WT1, GATA-4, and vimentin, with the presence of tight junctions and lipid droplets shown by oil red staining. After isolation, the CD49f+ cells were cocultured with RFP Sertoli cells in a 15-day time-course experiment. Positive immunostaining for meiosis markers SCP3 and CREST on days 3 to 5 was noted in the samples obtained from one NOA patient. A FISH analysis for chromosomes 13, 18, 21, X, and Y confirmed the presence of haploid cells on day

  3. Plasma Technology as a New Preservation Technique

    Science.gov (United States)

    Rincón, R.; Calzada, M. D.

    The preliminary results of using the surface wave discharge at the atmospheric pressure on groups of lentils and sherry Fino wine samples are presented. In this research, the capability of active species and UV radiation from the plasma, has been assessed on preservation of food. Besides, the generation and emission of both excited molecules in a metastable state N2}(B3Π {g-> A3}Σ u{+) and the de-excitation of species NO(A2}Σ {+) producing UV radiation have been also studied.

  4. N-doped carbon nanotubes-reinforced hollow fiber solid-phase microextraction coupled with high performance liquid chromatography for the determination of phytohormones in tomatoes.

    Science.gov (United States)

    Han, Xiao-Fei; Chen, Juan; Shi, Yan-Ping

    2018-08-01

    A N-doped carbon nanotubes-reinforced hollow fiber solid-phase microextraction (N-doped CNTs-HF-SPME) method was developed for determination of two naphthalene-derived phytohormones, 1-naphthalene acetic acid (NAA) and 2-naphthoxyacetic acid (2-NOA), at trace levels in tomatoes. N-doped CNTs were dispersed in ultrapure water with the assistance of surfactant, and then immobilized into the pores of hollow fiber by capillary forces and sonification. The resultant N-doped CNTs-HF was wetted with 1-octanol, subsequently immersed into the tomato samples to extract the target analytes under a magnetic stirring, and then desorbed with methanol by sonication prior to chromatographic analysis. Compared with CNTs, the surface hydrophilicity of N-doped CNTs was improved owing to the doping of nitrogen atoms, and a uniform dispersion was formed, thus greatly simplifying the preparation process and reducing waste of materials. In addition, N-doped CNTs-HF exhibits a more effective extraction performance for NAA and 2-NOA on account of the introduction of Lewis-basic nitrogen. It is worth to mention that owing to the clean-up function of HF, there are not any complicated sample pretreatment procedures prior to the microextraction. To achieve the highest extraction efficiency, important microextraction parameters including the length and the concentration level of N-doped CNTs in surfactant solution, extraction time, desorption conditions such as the type and volume of solvents, pH value, stirring rate and volume of the donor phase were thoroughly investigated and optimized. Under the optimal conditions, the method showed 165- and 123-fold enrichment factors of NAA and 2-NOA, good inter-fiber repeatability and batch-to-batch reproducibility, good linearity with correlation coefficients higher than 0.9990, low limits of detection and quantification (at ng g -1 levels), and satisfactory recoveries in the range of 83.10-108.32% at three spiked levels. The proposed method taking

  5. JEnsembl: a version-aware Java API to Ensembl data systems.

    Science.gov (United States)

    Paterson, Trevor; Law, Andy

    2012-11-01

    The Ensembl Project provides release-specific Perl APIs for efficient high-level programmatic access to data stored in various Ensembl database schema. Although Perl scripts are perfectly suited for processing large volumes of text-based data, Perl is not ideal for developing large-scale software applications nor embedding in graphical interfaces. The provision of a novel Java API would facilitate type-safe, modular, object-orientated development of new Bioinformatics tools with which to access, analyse and visualize Ensembl data. The JEnsembl API implementation provides basic data retrieval and manipulation functionality from the Core, Compara and Variation databases for all species in Ensembl and EnsemblGenomes and is a platform for the development of a richer API to Ensembl datasources. The JEnsembl architecture uses a text-based configuration module to provide evolving, versioned mappings from database schema to code objects. A single installation of the JEnsembl API can therefore simultaneously and transparently connect to current and previous database instances (such as those in the public archive) thus facilitating better analysis repeatability and allowing 'through time' comparative analyses to be performed. Project development, released code libraries, Maven repository and documentation are hosted at SourceForge (http://jensembl.sourceforge.net).

  6. CERN Technical Training 2006: Software and System Technologies Curriculum - Scheduled Course Sessions (October-December 2006)

    CERN Multimedia

    2006-01-01

    he Software and System Technologies Curriculum of the CERN Technical Training Programme offers comprehensive training in C++, Java, Perl, Python, XML, OO programming, JCOP/PVSS, database design and Oracle. In the PERL, C++, OO and Java course series there are some places available on the following course sessions, scheduled until the end of this year: Object-Oriented Analysis and Design using UML: 17-19 October 2006 (3 days) JAVA 2 Enterprise Edition - Part 1: Web Applications: 19-20 October 2006 (2 days) JAVA - Level 1: 30 Oct. -1 Nov. 2006 (3 days) PERL 5 - Advanced Aspects: 2 November 2006 (1 day) C++ Programming Part 1 - Introduction to Object-Oriented Design and Programming: 14-16 November 2006 (3 days) JAVA - Level 2: 4-7 December 2006 (4 days) C++ Programming Part 2 - Advanced C++ and its Traps and Pitfalls: 12-15 December 2006 (4 days) JAVA 2 Enterprise Edition - Part 2: Enterprise JavaBeans : 18.20 December 2006 (3 days) All the above sessions will be given in English, at the CERN Training Centre....

  7. CERN Technical Training 2006: Software and System Technologies Curriculum - Scheduled

    CERN Multimedia

    2006-01-01

    Course Sessions (October 2006-March 2007) The Software and System Technologies Curriculum of the CERN Technical Training Programme offers comprehensive training in C++, Java, Perl, Python, XML, OO programming, JCOP/PVSS, database design and Oracle. In the PERL, C++, OO and Java course series there are some places available on the following course sessions, currently scheduled until March 2007: Object-Oriented Analysis and Design using UML: 17-19 October 2006 (3 days) JAVA 2 Enterprise Edition - Part 1: Web Applications: 19-20 October 2006 (2 days) JAVA - Level 1: 30 October -1 November 2006 (3 days) PERL 5 - Advanced Aspects: 2 November 2006 (1 day) C++ Programming Part 1 - Introduction to Object-Oriented Design and Programming: 14-16 November 2006 (3 days) JAVA - Level 2: 4-7 December 2006 (4 days) C++ Programming Part 2 - Advanced C++ and its Traps and Pitfalls: 12-15 December 2006 (4 days) JAVA 2 Enterprise Edition - Part 2: Enterprise JavaBeans: 18-20 December 2006 (3 days) C++ for Particle Physicists:...

  8. A resource for benchmarking the usefulness of protein structure models

    Directory of Open Access Journals (Sweden)

    Carbajo Daniel

    2012-08-01

    Full Text Available Abstract Background Increasingly, biologists and biochemists use computational tools to design experiments to probe the function of proteins and/or to engineer them for a variety of different purposes. The most effective strategies rely on the knowledge of the three-dimensional structure of the protein of interest. However it is often the case that an experimental structure is not available and that models of different quality are used instead. On the other hand, the relationship between the quality of a model and its appropriate use is not easy to derive in general, and so far it has been analyzed in detail only for specific application. Results This paper describes a database and related software tools that allow testing of a given structure based method on models of a protein representing different levels of accuracy. The comparison of the results of a computational experiment on the experimental structure and on a set of its decoy models will allow developers and users to assess which is the specific threshold of accuracy required to perform the task effectively. Conclusions The ModelDB server automatically builds decoy models of different accuracy for a given protein of known structure and provides a set of useful tools for their analysis. Pre-computed data for a non-redundant set of deposited protein structures are available for analysis and download in the ModelDB database. Implementation, availability and requirements Project name: A resource for benchmarking the usefulness of protein structure models. Project home page: http://bl210.caspur.it/MODEL-DB/MODEL-DB_web/MODindex.php. Operating system(s: Platform independent. Programming language: Perl-BioPerl (program; mySQL, Perl DBI and DBD modules (database; php, JavaScript, Jmol scripting (web server. Other requirements: Java Runtime Environment v1.4 or later, Perl, BioPerl, CPAN modules, HHsearch, Modeller, LGA, NCBI Blast package, DSSP, Speedfill (Surfnet and PSAIA. License: Free. Any

  9. Dynamic Power-Saving Method for Wi-Fi Direct Based IoT Networks Considering Variable-Bit-Rate Video Traffic.

    Science.gov (United States)

    Jin, Meihua; Jung, Ji-Young; Lee, Jung-Ryun

    2016-10-12

    With the arrival of the era of Internet of Things (IoT), Wi-Fi Direct is becoming an emerging wireless technology that allows one to communicate through a direct connection between the mobile devices anytime, anywhere. In Wi-Fi Direct-based IoT networks, all devices are categorized by group of owner (GO) and client. Since portability is emphasized in Wi-Fi Direct devices, it is essential to control the energy consumption of a device very efficiently. In order to avoid unnecessary power consumed by GO, Wi-Fi Direct standard defines two power-saving methods: Opportunistic and Notice of Absence (NoA) power-saving methods. In this paper, we suggest an algorithm to enhance the energy efficiency of Wi-Fi Direct power-saving, considering the characteristics of multimedia video traffic. Proposed algorithm utilizes the statistical distribution for the size of video frames and adjusts the lengths of awake intervals in a beacon interval dynamically. In addition, considering the inter-dependency among video frames, the proposed algorithm ensures that a video frame having high priority is transmitted with higher probability than other frames having low priority. Simulation results show that the proposed method outperforms the traditional NoA method in terms of average delay and energy efficiency.

  10. Highly flexible peeled-off silver nanowire transparent anode using in organic light-emitting devices

    Energy Technology Data Exchange (ETDEWEB)

    Duan, Ya-Hui; Duan, Yu, E-mail: duanyu@jlu.edu.cn; Wang, Xiao; Yang, Dan; Yang, Yong-Qiang; Chen, Ping; Sun, Feng-Bo; Xue, Kai-Wen; Zhao, Yi

    2015-10-01

    Graphical abstract: - Highlights: • An ultra-smooth AgNW film on a flexible photopolymer substrate has been fabricated. • The AgNW film has a low sheet resistance with high transparency and flexibility. • OLEDs based on AgNW:NOA63 substrate can be bent at a radius of curvature of 2 mm. - Abstract: Materials to replace indium tin oxide (ITO) for high transmittance and electrical conductivity are urgently needed. In this paper, we adopted a silver nanowire (AgNW)-photopolymer (NOA63) film as a new platform for flexible optoelectronic devices. This design combined a transparent electrode and a flexible substrate. We utilized this application to obtain flexible organic light-emitting devices (FOLEDs). A peel-off process combined with a spin-coating process created an ultra-smooth silver nanowire anode on a photopolymer substrate. The performance of the device was achieved via the perfect morphology of the AgNW anode, the optimal 5 mg/ml concentration of AgNW solution, and the 45.7 Ω/□ sheet resistance of the AgNW film. The maximum current efficiency of the FOLED is 13 cd/A with stable mechanical flexibility even when bent to a radius of curvature of 2 mm. The outstanding performance of the FOLED with peeled off AgNW anode shows that this approach is a promising alternative to ITO for FOLEDs.

  11. Stress distribution and seismicity patterns of the 2011 seismic swarm in the Messinia basin, (South-Western Peloponnesus, Greece

    Directory of Open Access Journals (Sweden)

    G. Chouliaras

    2013-01-01

    Full Text Available In this investigation we examine the local stress field and the seismicity patterns associated with the 2011–2012 seismicity swarm in the Messinia basin, south-western Peloponnesus, Greece, using the seismological data of the National Observatory of Athens (NOA. During this swarm more than 2000 events were recorded in a 12 month period by the Hellenic Unified Seismological Network (HUSN and also by the additional local installation of four portable broadband seismographic stations by NOA.

    The results indicate a Gaussian distribution of swarm activity and the development of a seismicity cluster in a pre-existing seismic gap within the Messinia basin. Centroid Moment Tensor solutions demonstrate a normal fault trending northwest–southeast and dipping to the southwest primarily due to an extensional stress field. During this seismicity swarm an epicentre migration of the three largest shocks is observed, from one end of the rupture zone in the north-western part of the cluster, towards the other edge of the rupture in the south-eastern part of the cluster. This migration is found to follow the Coulomb failure criterion that predicts the advancement and retardation of the stress field and the patterns of increases and decreases of the seismicity rate (b-value of the frequency–magnitude relation.

  12. Highly versatile fiber-based optical Fabry-Pérot gas sensor.

    Science.gov (United States)

    Liu, Jing; Sun, Yuze; Fan, Xudong

    2009-02-16

    We develop a versatile, compact, and sensitive fiber-based optical Fabry-Pérot (FP) gas sensor. The sensor probe is composed of a silver layer and a vapor-sensitive polymer layer that are sequentially deposited on the cleaved fiber endface, thus forming an FP cavity. The interference spectrum resulting from the reflected light at the silver-polymer and polymer-air interfaces changes when the polymer is exposed to gas analytes. This structure enables using any polymer regardless of the polymer refractive index (RI), which significantly enhances the sensor versatility. In experiments, we use polyethylene glycol (PEG) 400 (RI=1.465-1.469) and Norland Optical Adhesive (NOA) 81 (RI=1.53-1.56) as the gas sensing polymer and show drastically different sensor response to hexanol, methanol, and acetone. The estimated sensitivity for methanol vapor is 3.5 pm/ppm and 0.1 pm/ppm for PEG 400 and NOA 81, respectively, with a detection limit on the order of 1-10 ppm. Gas sensing for the analytes delivered in both continuous flow mode and pulsed mode is demonstrated.

  13. Low concentrations of salicylic acid delay methyl jasmonate-induced leaf senescence by up-regulating nitric oxide synthase activity.

    Science.gov (United States)

    Ji, Yingbin; Liu, Jian; Xing, Da

    2016-09-01

    In plants, extensive efforts have been devoted to understanding the crosstalk between salicylic acid (SA) and jasmonic acid (JA) signaling in pathogen defenses, but this crosstalk has scarcely been addressed during senescence. In this study, the effect of SA application on methyl jasmonate (MeJA)-induced leaf senescence was assessed. We found that low concentrations of SA (1-50 μM) played a delayed role against the senescence promoted by MeJA. Furthermore, low concentrations of SA enhanced plant antioxidant defenses and restricted reactive oxygen species (ROS) accumulation in MeJA-treated leaves. When applied simultaneously with MeJA, low concentrations of SA triggered a nitric oxide (NO) burst, and the elevated NO levels were linked to the nitric oxide associated 1 (NOA1)-dependent pathway via nitric oxide synthase (NOS) activity. The ability of SA to up-regulate plant antioxidant defenses, reduce ROS accumulation, and suppress leaf senescence was lost in NO-deficient Atnoa1 plants. In a converse manner, exogenous addition of NO donors increased the plant antioxidant capacity and lowered the ROS levels in MeJA-treated leaves. Taken together, the results indicate that SA at low concentrations counteracts MeJA-induced leaf senescence through NOA1-dependent NO signaling and strengthening of the antioxidant defense. © The Author 2016. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  14. Intracytoplasmic sperm injection outcomes with cryopreserved testicular sperm aspiration samples.

    Science.gov (United States)

    Roque, M; Valle, M; Marques, F; Sampaio, M; Geber, S

    2016-04-01

    Intracytoplasmic sperm injection (ICSI) may be performed with testicular frozen-thawed spermatozoa in patients with nonobstructive azoospermia (NOA). Sperm retrieval can be performed in advance of oocyte aspiration, as it may avoid the possibility of no recovery of spermatozoa on the day of oocyte pickup. There are few studies available in the literature concerning the use of frozen-thawed spermatozoa obtained from testicular sperm aspiration (TESA). To evaluate the effects and the outcomes of ICSI with frozen-thawed spermatozoa obtained by TESA, we performed a retrospective analysis of 43 ICSI cycles using frozen-thawed TESA. We obtained acceptable results with a fertilisation rate of 67.9%, an implantation rate (IR) of 17.1%, and clinical and ongoing pregnancy rates of 41.9% and 37.2% respectively. The results of this study suggest that performing ICSI using cryopreserved frozen-thawed testicular spermatozoa with TESA as a first option is a viable, safe, economic and effective method for patients with NOA. © 2015 Blackwell Verlag GmbH.

  15. Microdissection Testicular Sperm Extraction (micro-TESE as a Sperm Acquisition Method for Men with Nonobstructive Azoospermia Seeking Fertility: Operative and Laboratory Aspects

    Directory of Open Access Journals (Sweden)

    Sandro C. Esteves

    2013-06-01

    Full Text Available Introduction Rare foci of sperm production may be found in up to 60% of men with nonobstructive azoospermia (NOA. Sperm production, if present, is minimal for sperm appearance in the ejaculate. Given that there are no treatment options to restore fertility, sperm retrieval is the only alternative to find testicular sperm than then can be used for in vitro fertilization (IVF. Among sperm acquisition methods, micro-TESE has higher success rates at obtaining sperm compared with testicular sperm extraction and testicular sperm aspiration. Materials and Methods This video describes the operative aspects of micro-TESE, performed on an outpatient basis, in a man with NOA and history of cryptorchidism in whom orchidopexy was performed at age 6. The concept of micro-TESE is to identify areas of sperm production within the testes with the aid of optical magnification (15-25X and based on the size and appearance of the seminiferous tubules (ST. Conclusion Micro-TESE allowed the identification and extraction of sperm-containing STs with minimum tissue excision and marked reduction in time processing of testicular specimens for sperm injection.

  16. Human Adrenocortical Remodeling Leading to Aldosterone-Producing Cell Cluster Generation

    Directory of Open Access Journals (Sweden)

    Koshiro Nishimoto

    2016-01-01

    Full Text Available Background. The immunohistochemical detection of aldosterone synthase (CYP11B2 and steroid 11β-hydroxylase (CYP11B1 has enabled the identification of aldosterone-producing cell clusters (APCCs in the subcapsular portion of the human adult adrenal cortex. We hypothesized that adrenals have layered zonation in early postnatal stages and are remodeled to possess APCCs over time. Purposes. To investigate changes in human adrenocortical zonation with age. Methods. We retrospectively analyzed adrenal tissues prepared from 33 autopsied patients aged between 0 and 50 years. They were immunostained for CYP11B2 and CYP11B1. The percentage of APCC areas over the whole adrenal area (AA/WAA, % and the number of APCCs (NOA, APCCs/mm2 were calculated by four examiners. Average values were used in statistical analyses. Results. Adrenals under 11 years old had layered zona glomerulosa (ZG and zona fasciculata (ZF without apparent APCCs. Some adrenals had an unstained (CYP11B2/CYP11B1-negative layer between ZG and ZF, resembling the rat undifferentiated cell zone. Average AA/WAA and NOA correlated with age, suggesting that APCC development is associated with aging. Possible APCC-to-APA transitional lesions were incidentally identified in two adult adrenals. Conclusions. The adrenal cortex with layered zonation remodels to possess APCCs over time. APCC generation may be associated with hypertension in adults.

  17. Controllable parabolic lensed liquid-core optical fiber by using electrostatic force.

    Science.gov (United States)

    Tang, Chun Yin; Zhang, Xuming; Chai, Yang; Hui, Long; Tao, Lili; Tsang, Yuen H

    2014-08-25

    For typical optical fiber system, an external lens accessory set is required to adjust the optical path of output light, which however is limited by the fixed parameter of the lens accessory setup. Considering spherical aberration in the imaging process and its small focusable spot size, a complicated lens combination is required to compensate the aberration. This paper has demonstrated a unique method to fabricate liquid-core lensed fibers by filling water and NOA61 respectively into hollow Teflon AF fibers and silicate fiber, the radius of curvature of the liquid lens can be controlled by adjusting the applied voltage on the core liquid and even parabolic shape lens can be produced with enough applied voltage. The experiment has successfully demonstrated a variation of focal length from 0.628 mm to 0.111 mm responding to the change of applied voltage from 0V to 3.2KV (L = 2mm) for the Teflon AF fiber, as well as a variation of focal length from 0.274 mm to 0.08 mm responding to the change of applied voltage from 0V to 3KV (L = 2mm) for the silicate fiber. Further simulation shows that the focused spot size can be reduced to 2 µm by adjusting the refractive index and fiber geometry. Solid state parabolic lensed fiber can be produced after NOA61 is solidified by the UV curing.

  18. [Births prevalence of 27 selected congenital anomalies in 7 geographic regions of Argentina].

    Science.gov (United States)

    Campaña, Hebe; Pawluk, Mariela S; López Camelo, Jorge S

    2010-10-01

    The aim of the present work was to estimate the frequency of 27 birth defects in 7 geographical regions of Argentina. Observational, cross-sectional, descriptive design. A sample of 21,844 new born with birth defects was selected, ascertained from 855,220 births, between 1994 and 2007, in 59 hospitals belonging to the ECLAMC network. In order to identify regions of high frequency a Poisson regression was used, adjusted by different hospitals from the same region. The model included a time variable to detect secular trends and 6 dummy variables for 7 predefined geographical regions: Metropolitana (MET); Pampa (PAM); Centro (CEN); Cuyo (CUY); Noroeste (NOA); Nordeste (NEA) and Patagonia (PAT). High frequencies regional analysis showed the following significant results: PAM: severe hypospadias; CEN: spina bifida, microtia, cleft lip with cleft palate, polycystic kidney, postaxial polydactyly and Down syndrome; CUY: postaxial polydactyly; NOA: omphalocele, gastroschisis, cleft lip without cleft palate, cleft lip with cleft palate, anorectal atresia/stenosis, indeterminate sex, preaxial polydactyly and pectoral agenesis; PAT: cleft lip without cleft palate. Out of the 27 congenital anomalies analyzed, fourteen showed a frequency significatively higher in one or more regions.

  19. EL IMPACTO DESIGUAL DE LAS TRANSFORMACIONES ECONÓMICAS EN CATAMARCA Y TUCUMÁN (1980- 2002

    Directory of Open Access Journals (Sweden)

    Ariel Osatinsky

    2013-01-01

    Full Text Available En el Noroeste argentino (NOA, Catamarca y Tucumán son dos provincias cuyo análisis adquiere un interés particular: la primera de ellas, con una estructura productiva más reducida y tradicional, mostraba a comienzos del siglo XXI el menor porcentaje de pobres de todo el norte del país, mientras que la segunda, a pesar de poseer la economía más desarrollada del NOA, tenía niveles más elevados de pobreza. Partiendo del supuesto que existe un fuerte vínculo entre la pobreza y la economía, y teniendo presente que las transformaciones económicas no se realizaron a un ritmo similar ni tampoco impactaron de un modo semejante en todas las provincias, la presente investigación analiza la evolución y las características que tuvieron las estructuras productivas de Catamarca y Tucumán entre 1980 y 2002. En particular, se examinan los cambios que atravesaron las actividades agropecuarias, la industria, el comercio y los servicios de ambas provincias.

  20. Photo polymerization-induced vertical phase separation and homeotropic alignment in liquid crystal and polymer mixtures

    International Nuclear Information System (INIS)

    Kang, Hyo; Joo, Sangwoo; Kang, Daeseung

    2012-01-01

    We presented a novel method for the homeotropic alignment of LC by using the irradiation of UV light on the LC/NOA65 mixture cell, in which the photo-initiated-polymerization-induced phase separation lowers the surface energy. When the amount of polymer content is sufficiently small, the gravel and network patterns were formed at the substrates via the vertical phase separation. We found that surface roughness plays an important role in the formation of the homeotropic alignment of LC. We also observed the alignment transition of the cells by varying the mixing ratio of LC/NOA65 or the UV radiation time. Furthermore, the present proposed method has great potential for application in display devices. For decades, studies on the alignment of liquid crystal (LC) molecules have been of significant interest due to their immediate applications for display devices and the intriguing physiochemical properties they exhibit at the surface of mixtures. Usually, homeotropic (or vertical) alignment, in which the long axes of the LC molecules are oriented in a direction perpendicular to the surface, is achieved by using surfactants such as lecithin, silanes or polyimide. Recently homeotropic alignment of liquid crystal molecules was achieved by irradiating photosensitive polymers, by doping nanoparticles into LC, by utilizing nano/micro patterns, or by incorporating self-assembled monolayers (SAMs). However, a clear understanding about the alignment mechanism is still elusive. In this paper, we report a novel method for homeotropic alignment of LC by utilizing the phase separation of LC/polymer mixtures

  1. Nonlinear optical rectification and optical absorption in GaAs-Ga1-xAlxAs asymmetric double quantum wells: Combined effects of applied electric and magnetic fields and hydrostatic pressure

    International Nuclear Information System (INIS)

    Karabulut, I.; Mora-Ramos, M.E.; Duque, C.A.

    2011-01-01

    The intersubband electron-related nonlinear optical absorption and nonlinear optical rectification in GaAs-Ga 1-x Al x As asymmetric double quantum wells are studied, under the influence of combined or independent applied electric and magnetic fields as well as hydrostatic pressure. The outcome of the density matrix formalism and the effective mass, and parabolic-band approximations have been considered as main theoretical tools for the description. It is obtained that under particular geometrical conditions, with or without electric and/or magnetic field strength, the optical rectification is null and, simultaneously, in such circumstances the optical absorption has a relative maximum. It is also detected that the influence of the hydrostatic pressure leads to increasing or decreasing behaviors of the nonlinear optical absorption in dependence of the particular regime of pressure values considered, with significant distinction of the cases of opposite electric field orientations. - Highlights: → Maxima of the NOA correspond to zero in the NOR. → Electric fields can couple the double quantum wells. → Hydrostatic pressure can couple the double quantum wells. → NOA can increase/decrease with hydrostatic pressure. → Overlap between wave functions depends on the magnetic field.

  2. Wildfire monitoring via the integration of remote sensing with innovative information technologies

    Science.gov (United States)

    Kontoes, C.; Papoutsis, I.; Michail, D.; Herekakis, Th.; Koubarakis, M.; Kyzirakos, K.; Karpathiotakis, M.; Nikolaou, C.; Sioutis, M.; Garbis, G.; Vassos, S.; Keramitsoglou, I.; Kersten, M.; Manegold, S.; Pirk, H.

    2012-04-01

    In the Institute for Space Applications and Remote Sensing of the National Observatory of Athens (ISARS/NOA) volumes of Earth Observation images of different spectral and spatial resolutions are being processed on a systematic basis to derive thematic products that cover a wide spectrum of applications during and after wildfire crisis, from fire detection and fire-front propagation monitoring, to damage assessment in the inflicted areas. The processed satellite imagery is combined with auxiliary geo-information layers, including land use/land cover, administrative boundaries, road and rail network, points of interest, and meteorological data to generate and validate added-value fire-related products. The service portfolio has become available to institutional End Users with a mandate to act on natural disasters and that have activated Emergency Support Services at a European level in the framework of the operational GMES projects SAFER and LinkER. Towards the goal of delivering integrated services for fire monitoring and management, ISARS/NOA employs observational capacities which include the operation of MSG/SEVIRI and NOAA/AVHRR receiving stations, NOA's in-situ monitoring networks for capturing meteorological parameters to generate weather forecasts, and datasets originating from the European Space Agency and third party satellite operators. The qualified operational activity of ISARS/NOA in the domain of wildfires management is highly enhanced by the integration of state-of-the-art Information Technologies that have become available in the framework of the TELEIOS (EC/ICT) project. TELEIOS aims at the development of fully automatic processing chains reliant on a) the effective storing and management of the large amount of EO and GIS data, b) the post-processing refinement of the fire products using semantics, and c) the creation of thematic maps and added-value services. The first objective is achieved with the use of advanced Array Database technologies, such

  3. A Model of RHIC Using the Unified Accelerator Libraries

    Energy Technology Data Exchange (ETDEWEB)

    Pilat, F. [Brookhaven National Lab. (BNL), Upton, NY (United States); Tepikian, S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Trahern, C. G. [Brookhaven National Lab. (BNL), Upton, NY (United States); Malitsky, N. [Cornell Univ., Ithaca, NY (United States)

    1998-01-01

    The Unified Accelerator Library (UAL) is an object oriented and modular software environment for accelerator physics which comprises an accelerator object model for the description of the machine (SMF, for Standard Machine Format), a collection of Physics Libraries, and a Perl inte,face that provides a homo­geneous shell for integrating and managing these components. Currently available physics libraries include TEAPOT++, a collection of C++ physics modules conceptually derived from TEAPOT, and DNZLIB, a differential algebra package for map generation. This software environment has been used to build a flat model of RHIC which retains the hierarchical lat­tice description while assigning specific characteristics to individual elements, such as measured field har­monics. A first application of the model and of the simulation capabilities of UAL has been the study of RHIC stability in the presence of siberian snakes and spin rotators. The building blocks of RHIC snakes and rotators are helical dipoles, unconventional devices that can not be modeled by traditional accelerator phys­ics codes and have been implemented in UAL as Taylor maps. Section 2 describes the RHIC data stores, Section 3 the RHIC SMF format and Section 4 the RHIC spe­cific Perl interface (RHIC Shell). Section 5 explains how the RHIC SMF and UAL have been used to study the RHIC dynamic behavior and presents detuning and dynamic aperture results. If the reader is not familiar with the motivation and characteristics of UAL, we include in the Appendix an useful overview paper. An example of a complete set of Perl Scripts for RHIC simulation can also be found in the Appendix.

  4. Sharing programming resources between Bio* projects through remote procedure call and native call stack strategies.

    Science.gov (United States)

    Prins, Pjotr; Goto, Naohisa; Yates, Andrew; Gautier, Laurent; Willis, Scooter; Fields, Christopher; Katayama, Toshiaki

    2012-01-01

    Open-source software (OSS) encourages computer programmers to reuse software components written by others. In evolutionary bioinformatics, OSS comes in a broad range of programming languages, including C/C++, Perl, Python, Ruby, Java, and R. To avoid writing the same functionality multiple times for different languages, it is possible to share components by bridging computer languages and Bio* projects, such as BioPerl, Biopython, BioRuby, BioJava, and R/Bioconductor. In this chapter, we compare the two principal approaches for sharing software between different programming languages: either by remote procedure call (RPC) or by sharing a local call stack. RPC provides a language-independent protocol over a network interface; examples are RSOAP and Rserve. The local call stack provides a between-language mapping not over the network interface, but directly in computer memory; examples are R bindings, RPy, and languages sharing the Java Virtual Machine stack. This functionality provides strategies for sharing of software between Bio* projects, which can be exploited more often. Here, we present cross-language examples for sequence translation, and measure throughput of the different options. We compare calling into R through native R, RSOAP, Rserve, and RPy interfaces, with the performance of native BioPerl, Biopython, BioJava, and BioRuby implementations, and with call stack bindings to BioJava and the European Molecular Biology Open Software Suite. In general, call stack approaches outperform native Bio* implementations and these, in turn, outperform RPC-based approaches. To test and compare strategies, we provide a downloadable BioNode image with all examples, tools, and libraries included. The BioNode image can be run on VirtualBox-supported operating systems, including Windows, OSX, and Linux.

  5. Cytological evaluation of spermatogenesis: a novel and simple diagnostic method to assess spermatogenesis in non-obstructive azoospermia using testicular sperm extraction specimens.

    Science.gov (United States)

    Hessel, M; de Vries, M; D'Hauwers, K W M; Fleischer, K; Hulsbergen-van de Kaa, C A; Braat, D D M; Ramos, L

    2015-05-01

    Most of the non-obstructive azoospermia (NOA)-patients have only focal spermatogenesis which results in insufficient numbers of spermatozoa to reach the ejaculate. In ≈50% of these NOA-patients testicular sperm extraction (TESE) is successful and intracytoplasmic sperm injection (ICSI) is pursued. We studied whether (i) spermatogenesis can be evaluated by defining the ratios between Sertoli cells, pachytene spermatocytes and spermatozoa in a testicular cell suspension, and (ii) these ratios are associated with the outcome of fertility treatment. A retrospective cohort study was conducted between June 2007 and August 2012. In this period, 441 consecutive ICSI-TESE cycles were performed in 212 couples. For each TESE biopsy, the ratios between Sertoli cells, pachytene spermatocytes and spermatozoa were calculated. A control population of 32 vasectomized men was used to define cut-off values for complete spermatogenesis. Based on the pachytene to sperm ratio (P/Sp) and number of spermatozoa per 100 Sertoli cells (#Sp/100SC) groups were defined as complete spermatogenesis, hypospermatogenesis and partial maturation arrest (MA). Validation of the cytological diagnoses was performed by comparing the results of cytology to the histological evaluation of spermatogenesis in 40 cases. In 92.5%, a perfect match was observed and in the three remaining cases cytology corresponded well with the results of TESE. Couples with complete spermatogenesis have a higher ongoing pregnancy rate after the first treatment cycle compared to couples with hypospermatogenesis (34 vs. 16%; p = 0.02) and partial MA (34 vs. 19%; p = 0.11). In conclusion, pachytene spermatocytes, spermatozoa and Sertoli cells can be easily identified and counted in a cell suspension and their ratios can be successfully used to diagnose the level of spermatogenic impairment. This pilot study indicates that once successful spermatozoa retrieval is achieved, treatment outcome declines when spermatogenesis is

  6. Public Resilience in CBRN Events: Lessons Learned from Seven Cases

    Science.gov (United States)

    2012-01-01

    babysitter in the states quit. Later Dr. Perl was told by the teen ‟s father that they were endangering his daughter by exposing her to SARS. While in...reported their family lives were impacted by anxiety, isolation, stress, depression and loved ones fearing for the caregiver‟s health. Those nurses...policy makers eliminated any sense of a farmer‟s ability to manage his own situation. Farmer‟s Unions stepped in and created a 24-hour suicide hotline

  7. Connecting the Real to the Representational: Historical Demographic Data in the Town of Pullman, 1880-1940

    Directory of Open Access Journals (Sweden)

    Andrew H. Bullen

    2007-12-01

    Full Text Available The Pullman House History Project is a part of the Pullman State Historic Site’s virtual museum and web site (http://www.pullman-museum.org/ which links together census, city directory, and telephone directory information to describe the people who lived in the town of Pullman, Illinois between 1881 and 1940. This demographic data is linked through a database/XML record system to online maps and Perl programs that allow the data to be represented in various useful combinations. This article describes the structure of the database and XML records, as well as the methods and code used to link the parts together and display the data.

  8. Programming languages for business problem solving

    CERN Document Server

    Wang, Shouhong

    2007-01-01

    It has become crucial for managers to be computer literate in today's business environment. It is also important that those entering the field acquire the fundamental theories of information systems, the essential practical skills in computer applications, and the desire for life-long learning in information technology. Programming Languages for Business Problem Solving presents a working knowledge of the major programming languages, including COBOL, C++, Java, HTML, JavaScript, VB.NET, VBA, ASP.NET, Perl, PHP, XML, and SQL, used in the current business computing environment. The book examin

  9. Macroscopic and microscopic aspects of collared peccary and white-lipped peccary placenta

    DEFF Research Database (Denmark)

    Santos, T.C.; Dantzer, Vibeke; Jones, C.J.P.

    2006-01-01

    with dispersed, basophilic and electrondense granules. Trophoblast cells are irregularly cuboidal on top of the fetal ridges and columnar on troughs, where cells have cytoplasmic vesicles and large basal vacuoles, surrounded by whorls of smooth membranes. Capillaries indent the trophoblast cells forming...... a placental barrier 3 µm or less thick. The columnar uterine glandular epithelium has a subpopulation of granules staining with Perl's Prussion blue reaction, suggesting iron secretion. In areolar areas, the trophoblast cells show apical microvilli, a basophilic cytoplasm with electron-dense intracellular...

  10. Accessing SDO data in a pipeline environment using the VSO WSDL/SOAP interface

    Science.gov (United States)

    Suarez Sola, F. I.; Hourcle, J. A.; Amezcua, A.; Bogart, R.; Davey, A. R.; Gurman, J. B.; Hill, F.; Hughitt, V. K.; Martens, P. C.; Spencer, J.; Vso Team

    2010-12-01

    As part of the Virtual Solar Observatory (VSO) effort to support the Solar Dynamics Observatory (SDO) data, the VSO has worked on bringing up to date its WSDL document and SOAP interface to make it compatible with most widely used web services core engines. (E.g. axis2, jws, etc.) In this presentation we will explore the possibilities available for searching and/or fetching data within pipeline code. We will explain some of the WSDL/VSO-SDO interface intricacies and show how the vast amount of data that is available via the VSO can be tapped via IDL, Java, Perl or C in an uncomplicated way.

  11. Public outreach: Multitudes attend the Night of Science

    CERN Multimedia

    2006-01-01

    The Night of Science, which took place in the parc de la Perle du Lac in Geneva last weekend, was a great success, with 30000 visitors attending according to the organisers. Many curious people flocked to the stands and animations until late on Saturday night and all afternoon on Sunday. The CERN stand (photo) received a great amount of interest from participants. Both kids and adults discovered the activities of the Laboratory and the data-processing revolution initiated by CERN, from the Web to the Computing Grid. Hats off to the CERN collaborators in the Communication Group and IT Department who made this event a success.

  12. Multitudes attend the Night of Science

    CERN Multimedia

    2006-01-01

    The Night of Science, which took place in the Parc de la Perle du Lac in Geneva last weekend, was a great success, with 30 000 visitors attending according to the organisers. Many curious people flocked to the stands and animations until late on Saturday night and all afternoon on Sunday. The CERN stand (photo) received a great amount of interest from participants. Both kids and adults discovered the activities of the Laboratory and the data-processing revolution initiated by CERN, from the Web to the Computing Grid. Hats off to the CERN collaborators in the Communication Group and IT Department who made this event a success.

  13. Regular Expression Pocket Reference

    CERN Document Server

    Stubblebine, Tony

    2007-01-01

    This handy little book offers programmers a complete overview of the syntax and semantics of regular expressions that are at the heart of every text-processing application. Ideal as a quick reference, Regular Expression Pocket Reference covers the regular expression APIs for Perl 5.8, Ruby (including some upcoming 1.9 features), Java, PHP, .NET and C#, Python, vi, JavaScript, and the PCRE regular expression libraries. This concise and easy-to-use reference puts a very powerful tool for manipulating text and data right at your fingertips. Composed of a mixture of symbols and text, regular exp

  14. Location and Routing of the Defense Courier Service Aerial Network

    Science.gov (United States)

    1991-03-01

    nature of the network is best described by a hierarchical depot model. Such a model is formulated by Perl and Daskin , and described by Chan and Rowell...AFIT/GOR/ENS/91M-1 Approved for public release; distribution is unlimited 91-05782 Form Aporo ,cd REPORT DOCUMENTATION PAGE 1 FoMNo 004-0o78 a -’saI c 1...addressed by clustering co-located demands with Kulkarni’s (1985) subtour breaking constraint. Vehicle range is considered by redressing a shortfall of the

  15. Conducting network penetration and espionage in a global environment

    CERN Document Server

    Middleton, Bruce

    2014-01-01

    When it's all said and done, penetration testing remains the most effective way to identify security vulnerabilities in computer networks. Conducting Network Penetration and Espionage in a Global Environment provides detailed guidance on how to perform effective penetration testing of computer networks-using free, open source, and commercially available tools, including Backtrack, Metasploit, Wireshark, Nmap, Netcat, and Nessus. It also considers exploits and other programs using Python, PERL, BASH, PHP, Ruby, and Windows PowerShell.The book taps into Bruce Middleton's decades of experience wi

  16. FloCon 2005 Proceedings

    Science.gov (United States)

    2005-09-01

    analysis interface than Perl, Python or shell scripts Full Access to R’s built-in statistical analysis capability R can run interactively or in batch...Prototyping Beginner Analyst  Faster time to productive investigations  rw switches can be made transparent to the user – concatenated together in the...SiLK, R, SQL, Python /C, etc. – Different UIs, same engine • "Dashboards" • Menu of "canned" queries • Sophisticated data exploration environment (e.g

  17. Automation Framework for Flight Dynamics Products Generation

    Science.gov (United States)

    Wiegand, Robert E.; Esposito, Timothy C.; Watson, John S.; Jun, Linda; Shoan, Wendy; Matusow, Carla

    2010-01-01

    XFDS provides an easily adaptable automation platform. To date it has been used to support flight dynamics operations. It coordinates the execution of other applications such as Satellite TookKit, FreeFlyer, MATLAB, and Perl code. It provides a mechanism for passing messages among a collection of XFDS processes, and allows sending and receiving of GMSEC messages. A unified and consistent graphical user interface (GUI) is used for the various tools. Its automation configuration is stored in text files, and can be edited either directly or using the GUI.

  18. Efficiency analysis of clearance of two types of exogenous iron from the rat brain by Moessbauer spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Polikarpov, D. M., E-mail: polikarpov.imp@gmail.com; Cherepanov, V. M.; Gabbasov, R. R. [National Research Centre, ' Kurchatov Institute' (Russian Federation); Chuev, M. A.; Mischenko, I. N. [Russian Academy of Sciences, Russian Institute of Physics and Technology (Russian Federation); Korshunov, V. A. [Russian Academy of Sciences, Institute of Higher Nervous Activity and Neurophysiology (Russian Federation); Panchenko, V. Y. [National Research Centre, ' Kurchatov Institute' (Russian Federation)

    2013-04-15

    Fe{sub 3}O{sub 4} based ferrofluid was injected transcranially in the ventricle of the rat brain. At 3 months after the injection the rat was sacrificed and the brain was investigated by Moessbauer spectroscopy and histological Perls Prussian blue method. Joint analysis of histological and Moessbauer data confirms that superparamagnetic nanoparticles Fe{sub 3}O{sub 4}, which constituted about 91 % of the iron of the ferrofluid, were cleared from the brain, while the concomitant chemical compound containing ferric ion in the high-spin state, remains intact.

  19. The Definitive Guide to SQLite

    CERN Document Server

    Owens, Mike

    2010-01-01

    Outside of the world of enterprise computing there is one database that enables a huge range of software and hardware to flex relational database capabilities, without the baggage and cost of traditional database management systems. That database is SQLite - an embeddable database with an amazingly small footprint, yet it can handle databases of enormous size. SQLite comes equipped with an array of powerful features available through a host of programming and development environments. It is supported by languages such as C, Java, Perl, PHP, Python, Ruby, TCL, and more. The Definitive Guide to

  20. Doublet method for very fast autocoding

    Directory of Open Access Journals (Sweden)

    Berman Jules J

    2004-09-01

    Full Text Available Abstract Background Autocoding (or automatic concept indexing occurs when a software program extracts terms contained within text and maps them to a standard list of concepts contained in a nomenclature. The purpose of autocoding is to provide a way of organizing large documents by the concepts represented in the text. Because textual data accumulates rapidly in biomedical institutions, the computational methods used to autocode text must be very fast. The purpose of this paper is to describe the doublet method, a new algorithm for very fast autocoding. Methods An autocoder was written that transforms plain-text into intercalated word doublets (e.g. "The ciliary body produces aqueous humor" becomes "The ciliary, ciliary body, body produces, produces aqueous, aqueous humor". Each doublet is checked against an index of doublets extracted from a standard nomenclature. Matching doublets are assigned a numeric code specific for each doublet found in the nomenclature. Text doublets that do not match the index of doublets extracted from the nomenclature are not part of valid nomenclature terms. Runs of matching doublets from text are concatenated and matched against nomenclature terms (also represented as runs of doublets. Results The doublet autocoder was compared for speed and performance against a previously published phrase autocoder. Both autocoders are Perl scripts, and both autocoders used an identical text (a 170+ Megabyte collection of abstracts collected through a PubMed search and the same nomenclature (neocl.xml, containing over 102,271 unique names of neoplasms. In side-by-side comparison on the same computer, the doublet method autocoder was 8.4 times faster than the phrase autocoder (211 seconds versus 1,776 seconds. The doublet method codes 0.8 Megabytes of text per second on a desktop computer with a 1.6 GHz processor. In addition, the doublet autocoder successfully matched terms that were missed by the phrase autocoder, while the

  1. A PARALLEL EXTENSION OF THE UAL ENVIRONMENT

    International Nuclear Information System (INIS)

    MALITSKY, N.; SHISHLO, A.

    2001-01-01

    The deployment of the Unified Accelerator Library (UAL) environment on the parallel cluster is presented. The approach is based on the Message-Passing Interface (MPI) library and the Perl adapter that allows one to control and mix together the existing conventional UAL components with the new MPI-based parallel extensions. In the paper, we provide timing results and describe the application of the new environment to the SNS Ring complex beam dynamics studies, particularly, simulations of several physical effects, such as space charge, field errors, fringe fields, and others

  2. e-RPG(V2) e-volving RPG applications for a connected world

    CERN Document Server

    Stone, Bradley V

    2014-01-01

    This companion to ""e-RPG: Building AS/400 Web Applications with RPG"" includes new techniques and functions to make e-RPG programming easier and more powerful than ever before. Not only does it provide the knowledge needed to create fully functional Web applications using OS/400 and RPG, but it also offers a thorough introduction to the Integrated Language Environment (ILE). Operators learn about using embedded SQL for easier and more effective queries, using e-RPG as Perl for OS/400, debugging information for e-RPG and JavaScript, and creating dynamic Web page changes. Users are also introdu

  3. The signature of sequential charged leptons

    International Nuclear Information System (INIS)

    Tsai, Y.S.

    1992-12-01

    I am honored to be invited to give a talk on this occasion to celebrate Martin Perl's 65th birthday. John Jaros, the organizer of this occasion, wanted me to recollect several things, especially: what motivated me to write my 1971 Physical Review paper on the heavy lepton entitled ''Decay Correlations of Heavy Lepton in e minus + e + = ell - + ell+;'' why did I think of muon-electron coincidence; and what were the contributions of Thacker and Sakurai. In this paper I answer his requests and add something else later

  4. Regular expressions cookbook

    CERN Document Server

    Goyvaerts, Jan

    2009-01-01

    This cookbook provides more than 100 recipes to help you crunch data and manipulate text with regular expressions. Every programmer can find uses for regular expressions, but their power doesn't come worry-free. Even seasoned users often suffer from poor performance, false positives, false negatives, or perplexing bugs. Regular Expressions Cookbook offers step-by-step instructions for some of the most common tasks involving this tool, with recipes for C#, Java, JavaScript, Perl, PHP, Python, Ruby, and VB.NET. With this book, you will: Understand the basics of regular expressions through a

  5. HP Vertica essentials

    CERN Document Server

    Agrawal, Rishabh

    2014-01-01

    This is a step-by-step guide with an easy-to-follow approach. A variety of diagrams and images support the concepts explored in the book. This book also contains important tips and tricks, thus making it a really useful reference for Vertica administration activities.If you are a Vertica user or DBA who wants to perform basic administration and fine tuning, this book is for you. Prior knowledge of Vertica will help you to understand the concepts better, but is not mandatory. Some intermediate knowledge of RDBMS, SQL, Linux, and scripting languages such as Perl or Python will be helpful.

  6. The influence of auxins on the biosynthesis of isoprene derivatives in callus cultures of Vaccinium corymbosum var. bluecrop.

    Science.gov (United States)

    Migas, Piotr; Luczkiewicz, Maria; Cisowski, Wojciech

    2006-01-01

    Callus cultures of Vaccinium corymbosum var. bluecrop were optimized for their isoprene derivatives production by supplementing Schenk-Hildebrandt (SH) medium with constant concentration of kinetin (2.32 microM) and two different amounts of selected auxins. Every auxin, except for IBA, used in 10-time higher concentration (2,4D, NAA, IAA, NOA) stimulated biosynthesis of beta-sitosterol and inhibited triterpene synthesis. Quantitative analysis of isoprene derivatives in callus biomass collected on the 25th day of the experiment proved that the analyzed callus of Vaccinium corymbosum var. bluecrop synthesized the highest amount of isoprene derivatives after subculturing on SH medium modified with 22.6 microM of 2,4D and 2.32 microM of kinetin.

  7. Polymer/silica hybrid waveguide temperature sensor based on asymmetric Mach-Zehnder interferometer

    Science.gov (United States)

    Niu, Donghai; Wang, Xibin; Sun, Shiqi; Jiang, Minghui; Xu, Qiang; Wang, Fei; Wu, Yuanda; Zhang, Daming

    2018-04-01

    A highly sensitive waveguide temperature sensor based on asymmetric Mach-Zehnder interferometer was designed and experimentally demonstrated. The interferometer is based on the polymer/silica hybrid waveguide structure, and Norland Optical Adhesive 73 (NOA 73) was employed as the waveguide core to enhance the temperature sensitivity. The influence of the different length differences between the two interferometer arms on the sensitivity of the sensor was systemically studied. It is shown that the maximum temperature sensitivity of -431 pm °C-1 can be obtained in the range of 25 °C-75 °C, while the length difference is 92 μm. Moreover, the temperature sensitivity contributions from different core materials were also investigated experimentally. It is shown that the waveguide material and microstructure of the device have significant influences on the sensitivity of the waveguide temperature sensor.

  8. Electrically and spatially controllable PDLC phase gratings for diffraction and modulation of laser beams

    Energy Technology Data Exchange (ETDEWEB)

    Hadjichristov, Georgi B., E-mail: georgibh@issp.bas.bg [Laboratory of Optics and Spectroscopy, Georgi Nadjakov Institute of Solid State Physics, Bulgarian Academy of Sciences, 72 Tzarigradsko Chaussee Blvd., BG-1784 Sofia (Bulgaria); Marinov, Yordan G.; Petrov, Alexander G. [Laboratory of Biomolecular Layers, Georgi Nadjakov Institute of Solid State Physics, Bulgarian Academy of Sciences, 72 Tzarigradsko Chaussee Blvd., BG-1784 Sofia, Bulgaria (Bulgaria)

    2016-03-25

    We present a study on electrically- and spatially-controllable laser beam diffraction, electrooptic (EO) phase modulation, as well as amplitude-frequency EO modulation by single-layer microscale polymer-dispersed liquid crystal (PDLC) phase gratings (PDLC SLPGs) of interest for device applications. PDLC SLPGs were produced from nematic liquid crystal (LC) E7 in photo-curable NOA65 polymer. The wedge-formed PDLC SLPGs have a continuously variable thickness (2–25 µm). They contain LC droplets of diameters twice as the layer thickness, with a linear-gradient size distribution along the wedge. By applying alternating-current (AC) electric field, the PDLC SLPGs produce efficient: (i) diffraction splitting of transmitted laser beams; (ii) spatial redistribution of diffracted light intensity; (iii) optical phase modulation; (iv) amplitude-frequency modulation, all controllable by the driven AC field and the droplet size gradient.

  9. Direct Determination of Range from Current Nuclear Overpressure Equations

    Science.gov (United States)

    1988-03-01

    wd 04 44d 0 00 4) a u 0o4 )( 00 0) 0 0 0 ’a 44 . 4bd . >’ 4.)44 Ik 0 4’) 4 4) 4𔃾 4 ’ 4’SQ 0 k~ 0 0 04 to W)) 0 ol4)wU) t 0) R 0 3t 00 4) 00 0 a)0Cu 4...0 1 0~~ + )QtO *?- n 40 ri - + M ON -4 0/0 000 t I el~~4 FA .000r- >(4r4ON - el 0 0 0 ai 060 CD -W- noa to - 0 N 0 1,0 00- c4 r-q% 4ny ol I’- o tD

  10. A General Quantum Mechanical Method to Predict Positron Spectroscopy

    Science.gov (United States)

    2007-06-01

    numnb+jjp) + cn((jap -1)*numnb+jjp) * cn((jrp -1)*numnb+jip))) end if c isep =(ja -1)*no*nnorb+(jr -1)*nnorb+jrp stmpb=sep( isep ) sep( isep )= stmp...continue c 250 continue c if(nxx.gt.0) go to 200 xlhf=0.0d+00 do ja=1,noa isep =(ja -1)*no*nnorb +(ja -1)*nnorb+1 xlhf=xlhf+ 2.0d+00*sep( isep ) end do xlep...0.0d+00 xeep=0.0d+00 jap=1 do 340 ja=1,noc do 330 jr=noc+1,no do 320 jrp=2,nnorb denom = eige(ja)+eign(jap)-eige(jr)-eign(jrp) isep =(ja -1)*no*nnorb+(jr

  11. Niveles séricos de minerales en hembras de cría bovina en un establecimiento de la región de selva y pastizal pedemontano del norte de Salta

    Directory of Open Access Journals (Sweden)

    MICHELOUD JF

    2017-12-01

    Full Text Available Las deficiencias minerales son un problema de gran impacto productivo a nivel mundial. En el Noroeste argentino (NOA la cría extensiva es una de las actividades económicas más importantes y está en franco crecimiento. En el NOA, los estudios sobre enfermedades carenciales son escasos y parciales. El presente trabajo tiene por objeto describir variaciones estacionales de los niveles séricos de calcio, fósforo, magnesio, cobre y zinc en vacas de cría y terneras de recría. En un establecimiento ganadero se seleccionaron 20 vacas y 20 terneras que fueron mantenidos en condiciones de pastoreo y sin suplementación externa. Se efectuaron muestreos de sangre a intervalos de 3 meses durante un año. Se determinaron niveles séricos de calcio, magnesio, cobre y zinc por espectrofotometría de absorción atómica y de fósforo por espectrofotometría uv-visible. Los resultados indican la existencia de hipocupremia moderada a leve en las terneras (48,6±11μg/dL durante todos los períodos muestreados. Las vacas presentaron valores promedio normales (66±3,5 μg/dL pero cercanos al límite inferior durante algunos muestreos. Se observaron niveles subnormales de fósforo durante el verano (diciembre y marzo en ambas categorías. Este trabajo sugiere que el cobre y el fósforo pueden comportarse como factores limitantes en las condiciones evaluadas. SUMMARY. Serum levels of minerals in beef heifers and cows in the cloudforest of Salta, Argentina. Mineral deficiencies are a problem of great productive impact worldwide. In the Argentine Northwest (NOA extensive breeding is one of the most important economic activities and it is in frank growth. In the NOA, studies on deficiency diseases are scarce and partial. The present work aims to describe seasonal variations of serum levels of calcium, phosphorus, magnesium, copper and zinc in beef cows and rearing calves. In a farm, 20 cows and 20 weaned heifer calves were selected, which were maintained under

  12. Heterogeneity of exposure and attribution of mesothelioma: Trends and strategies in two American counties

    International Nuclear Information System (INIS)

    Case, B W; Abraham, J L

    2009-01-01

    As mesothelioma risk has begun to decline in the United States, two trends are gaining relative importance. 'Legacy' exposures causing this disease are most important in locales having past asbestos industry, shipyards, and/or local distribution of asbestos amphibole-containing material as a result. 'Future' exposures are of particular concern in relation to so-called 'naturally occurring asbestos' (NOA) areas which include unequivocally asbestiform amphibole. In this paper, Jefferson Parish, Louisiana is used as an example of the first trend, and El Dorado County, California as an example of the second. Available tumor registry, epidemiology, historical and mineralogical data, and lung-retained fibre content are used as indicators of disease and exposure. Jefferson Parish, LA was chosen as the prototype of 'legacy' exposures on the basis of historical evidence of asbestos plants with known mesotheliomas in the workforce, known shipyards in the same area, EPA records of distribution of crocidolite-containing scrap to and remediation of over 1400 properties, NIOSH published data on mesothelioma by county, and exposure data including lung-retained fibre analyses in victims, where available. El Dorado, CA was chosen as the prototype of NOA amphibole exposures on the basis of tumor registry data, activity-based EPA sampling data in one area, and lung-retained fibre analyses in area pets, and future risk assessment based on tremolite-specific modelling in Libby, Montana and elsewhere. As expected, the legacy exposure area was high in mesothelioma incidence and mortality. Lung-retained fibre content confirms crocidolite exposures in exposed plant-workers and those exposed to crocidolite-containing scrap, and amosite in shipyard workers. In contrast, to date, cancer registry data in the NOA-amphibole ('future') county does not show a clear increase in incidence or mortality, but grouped county data from the area show a shift in higher incidence rates to the NOA areas and

  13. An experimental study of the fabrication of polycarbonate optical waveguides

    Science.gov (United States)

    Chen, Jianguo; Zhang, Xiao-yang; Zhang, Tong; Zhu, Jing-song; Wu, Peng-qin; Zhou, Jing-lun; Fan, Jiang-feng; Yan, Hao-feng

    2008-12-01

    A novel polycarbonate (PC) was introduced to apply in the optical waveguide devices. PC has following distinct merits than common polycarbonate: good processability, high thermal stability up to 293 C° and high optical transparency. Optical properties of absorption behavior and propagation loss were investigated in slab waveguides, and low propagation losses of 0.335 dB/cm (@1550nm) and 0.197 dB/cm @632.8nm) have been achieved by using prismcoupler. Additionally, straight optical waveguide and MMI coupler of ring resonator were fabricated using ultraviolet (UV) cured resin Norland optical adhesive 61 (NOA61) as under or upper cladding layer and polycarbonate as waveguide core-layer material through conventional methods such as spin coating, photolithography and reactive ion etching (RIE). The process was studied in detail and the experimental results were given.

  14. Design and analysis of dual-resonant filters in visible and infra-red region based on polymer LPWG

    Science.gov (United States)

    Sharma, Mukesh; Kushwaha, Aniruddha Singh; Pal, Suchandan

    2013-01-01

    Long-period waveguide gratings (LPWGs), by using a SU-8 polymer-based channel waveguide along with NOA61 optical epoxy coated upper- and lower-cladding, are designed and theoretical analyzed. Grating period of ~ 68μm is considered with optimized grating tooth-heights, so that the transmission spectra of the gratings show strong rejection bands both at visible (450 - 460 nm) and infrared (1530 - 1540 nm) wavelength regions. Phase-matching graphs are studied in order to observe the change in resonance wavelength of the grating with the variation of waveguide parameters. LPWG-based band pass filter are also designed and analyzed by considering the same set of polymer materials. Further, temperature sensitivity of these LPWGs is analyzed theoretically. These types of waveguide gratingbased filters can widely be used for visible and infrared wavelength sensing applications.

  15. Morphological studies of polymer dispersed liquid crystal materials

    International Nuclear Information System (INIS)

    Han, Jin-Woo

    2006-01-01

    In this work, we have studied the morphologies of polymer dispersed liquid crystals (PDLCs) based on E7/NOA61. Scanning electron microscope studies show that the PDLC morphology is strongly affected by the LC concentration and the cure temperature. A typical PDLC morphology with isolated LC droplets dispersed in a polymer matrix is only observed at low LC compositions and at low cure temperatures. Increasing either the LC composition or the cure temperature results in a polymer ball morphology, in which LCs exist in irregularly shaped voids in the polymer network structure. It is shown that the transition between these two morphologies can be qualitatively explained using a pseudo-binary phase diagram.

  16. Heterogeneity of exposure and attribution of mesothelioma: Trends and strategies in two American counties

    Science.gov (United States)

    Case, B. W.; Abraham, J. L.

    2009-02-01

    As mesothelioma risk has begun to decline in the United States, two trends are gaining relative importance. "Legacy" exposures causing this disease are most important in locales having past asbestos industry, shipyards, and/or local distribution of asbestos amphibole-containing material as a result. "Future" exposures are of particular concern in relation to so-called "naturally occurring asbestos" (NOA) areas which include unequivocally asbestiform amphibole. In this paper, Jefferson Parish, Louisiana is used as an example of the first trend, and El Dorado County, California as an example of the second. Available tumor registry, epidemiology, historical and mineralogical data, and lung-retained fibre content are used as indicators of disease and exposure. Jefferson Parish, LA was chosen as the prototype of "legacy" exposures on the basis of historical evidence of asbestos plants with known mesotheliomas in the workforce, known shipyards in the same area, EPA records of distribution of crocidolite-containing scrap to and remediation of over 1400 properties, NIOSH published data on mesothelioma by county, and exposure data including lung-retained fibre analyses in victims, where available. El Dorado, CA was chosen as the prototype of NOA amphibole exposures on the basis of tumor registry data, activity-based EPA sampling data in one area, and lung-retained fibre analyses in area pets, and future risk assessment based on tremolite-specific modelling in Libby, Montana and elsewhere. As expected, the legacy exposure area was high in mesothelioma incidence and mortality. Lung-retained fibre content confirms crocidolite exposures in exposed plant-workers and those exposed to crocidolite-containing scrap, and amosite in shipyard workers. In contrast, to date, cancer registry data in the NOA-amphibole ("future") county does not show a clear increase in incidence or mortality, but grouped county data from the area show a shift in higher incidence rates to the NOA areas and

  17. Effects of design geometry on SU8 polymer waveguides

    Science.gov (United States)

    Holland, Anthony S.; Balkunje, Vishal S.; Mitchell, Arnan; Austin, Michael W.; Raghunathan, Mukund K.; Kostovski, Gorgi

    2005-02-01

    The spin-on photoresist SU8 from MicroChem has a relatively high refractive index (n=1.57 at 1550nm) compared with other polymers. It is stable and has high optical transmission at optical communication wavelengths. In this paper we study rib waveguides fabricated using SU8 as the core layer and thermoset polymers UV15 (n=1.50 at 1550nm) from Master Bond and NOA61 (n=1.54 at 1550nm) from Gentec as the cladding layers. The rib height is varied from 0.3 to 1.7μm high. This is part of the SU8 layer sandwiched between the cladding layers. The waveguides are tested to determine the effects of varying this geometry for single mode optical transmission. The lengths of the waveguides were 1.5 cm to 5 cm.

  18. Inhibitory effect of common microfluidic materials on PCR outcome

    KAUST Repository

    Kodzius, Rimantas

    2012-02-20

    compatibility of various materials commonly used while producing microfluidic devices is also pertinent and beneficial to other enzymatic reactions in microfluidic devices. Most PCR-friendly materials exhibit similar signals regardless of the inclusion or not of BSA in the PCR mixture; these materials are PP, PTFE, PDMS, wax (Tm 80°C), SiO2 quartz, pyrex and soda-lime glasses, NOA68, and mineral oil. Our results showed that there was near total adsorption of template DNA when the wax (Tm 60°C) was used (RBI = 9.2×101). In contrast, when NOA61, mineral oil and acrylic glue materials were employed, significant adsorption occurred (RBI < 1.5×103). The polymerase-inhibition experiments indicate that following materials do not have strong effects (RBI > 1.1×103) on polymerase: PC, PP, PTFE, PDMS, silicon with a layer of 560 nm SiO2, SiO2 quartz, pyrex, and soda-lime glass. Slight polymerase inhibition (RBI < 9.2×102) was observed with PMMA, PVC, waxes (Tm 56°C and 80°C), silicon, and NOA68. A very strong or near total inhibition (RBI < 1.8×102) was observed with wax (Tm 60°C), ITO glass, SU-8, NOA61, metal tubes, mineral oil, epoxy, and the acrylic glues. \\tOur results show that material selection for microfluidic PCR chips, which are characterized by large SAVR, is a vital part of optimizing PCR outcome. This study of the inhibitory effect of various common microfluidics materials has provided a new rapid testing method using only a PCR cycler, and it has confirmed and expanded the list of tested materials. The type of PCR compatibility test enables the most effectual choice of materials for use in biology-related experiments.

  19. Heterogeneity of exposure and attribution of mesothelioma: Trends and strategies in two American counties

    Energy Technology Data Exchange (ETDEWEB)

    Case, B W [Department of Pathology and School of Environment, McGill University, Montreal, Quebec (Canada); Abraham, J L, E-mail: bruce.case@mcgill.c [Department of Pathology, SUNY Upstate Medical University, Syracuse, NY 13210 (United States)

    2009-02-01

    As mesothelioma risk has begun to decline in the United States, two trends are gaining relative importance. 'Legacy' exposures causing this disease are most important in locales having past asbestos industry, shipyards, and/or local distribution of asbestos amphibole-containing material as a result. 'Future' exposures are of particular concern in relation to so-called 'naturally occurring asbestos' (NOA) areas which include unequivocally asbestiform amphibole. In this paper, Jefferson Parish, Louisiana is used as an example of the first trend, and El Dorado County, California as an example of the second. Available tumor registry, epidemiology, historical and mineralogical data, and lung-retained fibre content are used as indicators of disease and exposure. Jefferson Parish, LA was chosen as the prototype of 'legacy' exposures on the basis of historical evidence of asbestos plants with known mesotheliomas in the workforce, known shipyards in the same area, EPA records of distribution of crocidolite-containing scrap to and remediation of over 1400 properties, NIOSH published data on mesothelioma by county, and exposure data including lung-retained fibre analyses in victims, where available. El Dorado, CA was chosen as the prototype of NOA amphibole exposures on the basis of tumor registry data, activity-based EPA sampling data in one area, and lung-retained fibre analyses in area pets, and future risk assessment based on tremolite-specific modelling in Libby, Montana and elsewhere. As expected, the legacy exposure area was high in mesothelioma incidence and mortality. Lung-retained fibre content confirms crocidolite exposures in exposed plant-workers and those exposed to crocidolite-containing scrap, and amosite in shipyard workers. In contrast, to date, cancer registry data in the NOA-amphibole ('future') county does not show a clear increase in incidence or mortality, but grouped county data from the area show a

  20. Application of β-cyclodextrin-modified, carbon nanotube-reinforced hollow fiber to solid-phase microextraction of plant hormones.

    Science.gov (United States)

    Song, Xin-Yue; Ha, Wei; Chen, Juan; Shi, Yan-Ping

    2014-12-29

    A new, efficient, and environmental friendly solid-phase microextraction (SPME) medium based on β-cyclodextrin (β-CD)-modified carbon nanotubes (CNTs) and a hollow fiber (HF) was prepared. Functionalized β-CD was covalently linked to the surface of the carboxylic CNTs and then the obtained nanocomposite was immobilized into the wall pores of HFs under ultrasonic-assisted effect. The scanning electron microscope was used to inspect surface characteristics of fibers, demonstrating the presence of nanocomposites in their wall pores. The reinforced HF was employed in SPME, and its extraction performance was evaluated by analyzing 1-naphthaleneacetic acid (NAA) and 2-naphthoxyacetic acid (2-NOA) in vegetables. Without any tedious clean-up procedure, analytes were extracted from the sample to the adsorbent and organic solvent immobilized in HFs and then desorbed in acetonitrile prior to chromatographic analysis. Under the optimized extraction conditions, the method provided 275- and 283-fold enrichment factors of NAA and 2-NOA, low limits of detection and quantification (at an ngg(-1) level), satisfactory spiked recoveries, good inter-fiber repeatability, and batch-to-batch reproducibility. The selectivity of the developed fiber was investigated to three structurally similar compounds and two reference compounds with recognition coefficients up to 3.18. The obtained results indicate that the newly developed fiber is a feasible, selective, green, and cost-effective microextraction medium and could be successfully applied for extraction and determination of naphthalene-derived plant hormones in complex matrices. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. The Effect of Human Chorionic Gonadotropin Treatment Before Testicular Sperm Extraction in Non-Obstructive Azoospermia

    Directory of Open Access Journals (Sweden)

    Ümit Gul

    2014-12-01

    Full Text Available Aim: To investigate our experience on empirical hCG treatment of patients with idiopathic non-obstructive azoospermia (NOA. Material and Method: hCG group consisted of 34 patients who were empirically treated with hCG despite normal serum FSH and LH levels and normal testicular volumes. hCG was administered as 2500 IU twice weekly subcutaneous injections for 10 to 14 weeks prior to testicular sperm extraction (TESE. Control group consisted of 49 age and spouse age matched patients who underwent TESE in the same time period. Sperm retrieval rate (SRR, and follicle stimulating hormone (FSH, lutenizing hormone (LH and testosterone levels, volume of testicles, fertilization rate (FR, implantation rate (IR, pregnancy rate (PR, live birth rate (LBR and cancel rate (CR and surgical technique were compared between the two groups. Results: Conventional technique was used in 14 of the 17 patients (82.3% with successful sperm retrieval in the hCG group, and 18 of the 28 patients (64.3% in the control group (p=0.170. There were no differences between groups in terms of SRR (p=0.338. There were no significant differences in patient age, mean infertility period, mean values of FSH, LH, testosterone, estradiol levels, and testis volume between the two groups (p>0.05. There were no statistically significant differences for FR, IR, PR, LBR between the two groups (p>0.05. Discussion: Empirical hCG treatment in patients with idiopathic NOA did not result in improved SRR. hCG treatment did not have any effect on the success of ICSI.

  2. Condiciones de vida y fragmentación socio-espacial en el aglomerado Gran San Miguel de Tucumán (Noroeste Argentino

    Directory of Open Access Journals (Sweden)

    Paula Boldrini Peralta

    2014-06-01

    Full Text Available El noroeste de Argentina (NOA es el territorio donde la pobreza alcanza las condiciones más críticas y la calidad de vida registra los estándares más bajos. El aglomerado Gran San Miguel de Tucumán (GSMT constituye la ciudad cabecera de la región. Concentra niveles significativos de privación sin ocupar la situación más desfavorable, manifestando procesos de fragmentación socio-espacial a partir del sostenimiento y la agudización de las desigualdades entre sus habitantes. El objetivo es caracterizar y analizar las condiciones de vida del aglomerado GSMT a principios del siglo XXI. Para esto se utiliza el índice sintético de condiciones de vida urbano (que combina el índice de privación material de los hogares y el índice de calidad de vida urbano para detectar aquellas variables que inciden en el territorio y que generan las mejores y peores situaciones socio-espaciales del aglomerado, identificando sus características particulares. Northwestern Argentina (NOA is the territory where poverty reaches the most critical conditions and quality of life has the lowest standards. The agglomerate Gran San Miguel de Tucumán (GSMT is the main city in the region. It concentrate significant levels of privation but not the most unfavorable situation, showing processes of socio-spatial fragmentation and growing inequalities among its habitants. The objective is to characterize and analyze the living conditions of the agglomerate GSMT in the early twenty-first century. Using the syntheticalrating of urban living conditions (combiningthe material privation rating of households with the rating of urban life quality recognizing variables that affect the territory and generate the best and worst case scenarios in socio-spatial situations of the agglomerate, identifying their main characteristics.

  3. Regulation of reactive oxygen and nitrogen species by salicylic acid in rice plants under salinity stress conditions

    Science.gov (United States)

    Mun, Bong-Gyu; Khan, Abdul Latif; Waqas, Muhammad; Kim, Hyun-Ho; Shahzad, Raheem; Imran, Muhammad

    2018-01-01

    This study investigated the regulatory role of exogenous salicylic acid (SA) in rice and its effects on toxic reactive oxygen and nitrogen species during short-term salinity stress. SA application (0.5 and 1.0 mM) during salinity-induced stress (100 mM NaCl) resulted in significantly longer shoot length and higher chlorophyll and biomass accumulation than with salinity stress alone. NaCl-induced reactive oxygen species production led to increased levels of lipid peroxidation in rice plants, which were significantly reduced following SA application. A similar finding was observed for superoxide dismutase; however, catalase (CAT) and ascorbate peroxidase (APX) were significantly reduced in rice plants treated with SA and NaCl alone and in combination. The relative mRNA expression of OsCATA and OsAPX1 was lower in rice plants during SA stress. Regarding nitrogenous species, S-nitrosothiol (SNO) was significantly reduced initially (one day after treatment [DAT]) but then increased in plants subjected to single or combined stress conditions. Genes related to SNO biosynthesis, S-nitrosoglutathione reductase (GSNOR1), NO synthase-like activity (NOA), and nitrite reductase (NIR) were also assessed. The mRNA expression of GSNOR1 was increased relative to that of the control, whereas OsNOA was expressed at higher levels in plants treated with SA and NaCl alone relative to the control. The mRNA expression of OsNR was decreased in plants subjected to single or combination treatment, except at 2 DAT, compared to the control. In conclusion, the current findings suggest that SA can regulate the generation of NaCl-induced oxygen and nitrogen reactive species in rice plants. PMID:29558477

  4. Cambios globales en el Noroeste Argentino con referencias a la provincia más pequeña de Argentina: Tucumán

    Directory of Open Access Journals (Sweden)

    González, J. A.

    2008-12-01

    Full Text Available With 20% of the surface of the country, the 12% of the population lives in Northwest Argentina (NOA. Tucumán has a rugged topography of strong altitudinal clines (from 180 to 7,084m a.s.l. where a series of plant formations, animal species and environmental services have been developed, those have been replaced through time by intensive agriculture, extensive livestock, a nascent industry and some urban areas. The unplanned use of natural resources (including water, soil, forest, mineral resources, among others in time, has brought the region to a serious environmental situation that can not qualify as sustainable. If we add to this scenario the effects of climate change, the region shows a state of global change that could affect both lasting resources and economic activities, with which the region has based its economy.

    En el Noroeste Argentino (NOA, que representa el 20 % de la superficie de Argentina vive el 12 % de la población del país. La región se caracteriza por una topografía de fuertes desniveles altitudinales (desde 180 hasta 7.084 m.s.n.m. donde se han desarrollado una serie de formaciones vegetales y usos del suelo caracterizados por campos de cultivo, ganadería, una incipiente industria y ciudades. La falta de planificación de múltiples recursos naturales (agua, suelo, bosques, recursos minerales, entre otros ha llevado a una situación de insostenibilidad; si a ello se añade el cambio climático, la región se halla en una situación de cambios globales que podrían afectar a los recursos en las que se basan las actividades económicas.

  5. Regiões de saúde e escalas geográficas

    Directory of Open Access Journals (Sweden)

    Guimarães Raul Borges

    2005-01-01

    Full Text Available O presente artigo tem como objetivo central discutir o processo de regionalização da saúde no país, considerando-se o novo cenário de direcionamento do investimento de unidades públicas de saúde, a partir da publicação da Norma Operacional de Assistência à Saúde (NOAS - SUS 01/2001. Para isso, um esforço faz-se necessário: o de superação da compreensão predominante a respeito de alguns conceitos, principalmente o de região e de escala geográfica. A proposta de divisão regional dessa NOAS baseia-se no conceito de região de planejamento que, desde a fundação do Instituto Brasileiro de Geografia e Estatística, tem subsidiado as políticas territoriais do Estado brasileiro. Contudo, a regionalização da saúde no Brasil é uma necessidade para o fortalecimento do SUS e uma mudança qualitativa da política nacional de saúde. É preciso avançar, relacionando a divisão regional do Brasil com a questão da escala. O que está em questão é se a regionalização da saúde brasileira representa ou não um aprimoramento das mediações entre as diversas escalas do SUS.

  6. Macrophage imaging by USPIO-enhanced MR for the differentiation of infectious osteomyelitis and aseptic vertebral inflammation

    Energy Technology Data Exchange (ETDEWEB)

    Bierry, Guillaume [University Hospital, Department of Radiology, Strasbourg (France); University Louis Pasteur, EA 3432, Strasbourg (France); Jehl, Francois [University Hospital of Strasbourg, Department of Bacteriology, Strasbourg (France); University Louis Pasteur, EA 3432, Strasbourg (France); Boehm, Nelly [University Louis Pasteur, Institute of Histology, Faculty of Medicine, Strasbourg (France); University Louis Pasteur, INSERM U666, Strasbourg (France); Robert, Philippe [Guerbet Research, Roissy (France); Dietemann, Jean-Louis; Kremer, Stephane [University Hospital, Department of Radiology, Strasbourg (France)

    2009-07-15

    The purpose of this study was to prospectively evaluate USPIO-enhanced MR imaging for the differentiation of vertebral infectious osteomyelitis and sterile inflammation. Vertebral osteomyelitis and sterile vertebral inflammation were induced in two groups of six rabbits each. MRI examinations were performed including unenhanced and gadolinium-enhanced fat-saturated SE T1w sequences. Once endplate enhancement was observed on the T1 gadolinium-enhanced MR sequence, a second MRI examination (SE T1w sequence) was performed 24 h after USPIO administration (45 {mu}mol Fe/kg). MR imaging was correlated with histopathological findings (macrophage immunostaining and Perls Prussian blue staining). On gadolinium-enhanced T1 sequences, a significant SNR increase in vertebral endplates was present in both groups without significant difference between the two groups (P = 0.26). On USPIO-enhanced T1 sequences, a significant SNR increase was only observed in the infection group (P = 0.03) with a significant difference in SNR between the infection and the sterile-inflammation groups (P = 0.002). Infected areas presented replacement of bone marrow by an intense macrophage infiltration, some being iron-loaded. Sterile inflammation showed a replacement of bone marrow by inflammatory tissue with only rare macrophages without any Perls blue staining. USPIO-enhanced MR imaging can distinguish infectious osteomyelitis from sterile vertebral inflammation due to different macrophage distributions in the two lesions. (orig.)

  7. The HEASARC Swift Gamma-Ray Burst Archive: The Pipeline and the Catalog

    Science.gov (United States)

    Donato, Davide; Angelini, Lorella; Padgett, C.A.; Reichard, T.; Gehrels, Neil; Marshall, Francis E.; Sakamoto, Takanori

    2012-01-01

    Since its launch in late 2004, the Swift satellite triggered or observed an average of one gamma-ray burst (GRB) every 3 days, for a total of 771 GRBs by 2012 January. Here, we report the development of a pipeline that semi automatically performs the data-reduction and data-analysis processes for the three instruments on board Swift (BAT, XRT, UVOT). The pipeline is written in Perl, and it uses only HEAsoft tools and can be used to perform the analysis of a majority of the point-like objects (e.g., GRBs, active galactic nuclei, pulsars) observed by Swift. We run the pipeline on the GRBs, and we present a database containing the screened data, the output products, and the results of our ongoing analysis. Furthermore, we created a catalog summarizing some GRB information, collected either by running the pipeline or from the literature. The Perl script, the database, and the catalog are available for downloading and querying at the HEASARC Web site.

  8. Technical Training: Places available

    CERN Multimedia

    Monique Duval

    2004-01-01

    The number of places available may vary. Please check our Web site to find out the current availability. Places are available in the following courses: Explicit Dynamics with ANSYS/LS-Dyna : 7 - 9.12.2004 (3 days) Introduction to PERL 5 : 8 & 9.12.2004 (2 days) PCAD Schémas - Débutants : 9 & 10.12.2004 (2 jours) Advanced aspects of PERL 5: 10.12.2004 (1 day) PCAD PCB – Débutants : 13 - 15.12.2004 (3 jours) The JAVA Programming Language Level 1 : 11 & 12.1.2005 (2 days) Introduction to XML : 13 & 14.1.2005 (2 days) Introduction to the CERN EDMS : 18.1.2005 (1 day - free course) The CERN EDMS for Local Administrators : 19 & 20.1.2005 (2 days - free course) Programmation Unity-Pro pour utilisateurs de Schneider PL7-Pro : 24 - 28.1.2005 (8 demi-journées) CLEAN-2002 : Travailler en salle propre : 25.1.2005 (après-midi, cours gratuit) Compatibilit&eac...

  9. Technical Training: Places available

    CERN Multimedia

    Monique Duval

    2004-01-01

    The number of places available may vary. Please check our Web site to find out the current availability. Places are available in the following courses: FileMaker - niveau 1 : 23 - 26.11.2004 (4 jours) Explicit Dynamics with ANSYS/LS-Dyna : 7 - 9.12.2004 (3 days) Introduction to PERL 5 : 8 & 9.12.2004 (2 days) PCAD Schémas - Débutants : 9 & 10.12.2004 (2 jours) Advanced aspects of PERL 5: 10.12.2004 (1 day) PCAD PCB – Débutants : 13 - 15.12.2004 (3 jours) The JAVA Programming Language Level 1 : 11 & 12.1.2005 (2 days) Introduction to XML : 13 & 14.1.2005 (2 days) Introduction to the CERN EDMS : 18.1.2005 (1 day - free course) The CERN EDMS for Local Administrators : 19 & 20.1.2005 (2 days - free course) Programmation Unity-Pro pour utilisateurs de Schneider PL7-Pro : 24 - 28.1.2005 (8 demi-journées) CLEAN-2002 : Travailler en salle propre : 25.1.2005 ...

  10. Open source clustering software.

    Science.gov (United States)

    de Hoon, M J L; Imoto, S; Nolan, J; Miyano, S

    2004-06-12

    We have implemented k-means clustering, hierarchical clustering and self-organizing maps in a single multipurpose open-source library of C routines, callable from other C and C++ programs. Using this library, we have created an improved version of Michael Eisen's well-known Cluster program for Windows, Mac OS X and Linux/Unix. In addition, we generated a Python and a Perl interface to the C Clustering Library, thereby combining the flexibility of a scripting language with the speed of C. The C Clustering Library and the corresponding Python C extension module Pycluster were released under the Python License, while the Perl module Algorithm::Cluster was released under the Artistic License. The GUI code Cluster 3.0 for Windows, Macintosh and Linux/Unix, as well as the corresponding command-line program, were released under the same license as the original Cluster code. The complete source code is available at http://bonsai.ims.u-tokyo.ac.jp/mdehoon/software/cluster. Alternatively, Algorithm::Cluster can be downloaded from CPAN, while Pycluster is also available as part of the Biopython distribution.

  11. Balancing electrical and optical losses for efficient Si-perovskite 4-terminal solar cells with solution processed percolation electrodes.

    KAUST Repository

    Ramírez Quiroz, César Omar

    2018-01-15

    The unprecedented efficiency upraise of perovskite-based photovoltaics has sparked the interest in semi-transparent devices, particularly for tandem structures. Despite promising reports regarding efficiency and reduced parasitic absorption, many devices still rely on processes from the gas phase, compromising both applicability and cost factors. Here, we report all-solution perovskite solar cells with improved infrared transparency ideally suited as top-cell for efficient multi-junction device configurations. We demonstrate the functionality of Copper (I) thiocyanate as antireflective layer and selective contact between the transparent conductive oxide and the perovskite as key factor. This concept allows us to fabricate an opaque device with steady state efficiency as high as 20.1%. By employing silver nanowires with robust environmental stability as bottom electrode, we demonstrate different regimes of device performance that can be described through a classical percolation model, leading to semi-transparent solar cells with efficiencies of up to 17.1%. In conjunction with the implementation of an infrared-tuned transparent conductive oxide contact deposited on UV-fused silica, we show a full device average transmittance surpassing 84% between 800 and 1100 nm (as opposed to 77% with PEDOT:PSS as selective contact). Finally, we mechanically staked optimized perovskite devices on top of high performing PERL and IBC silicon architectures. The imputed output efficiency of the 4-terminal measured perovskite-silicon solar cell was 26.7% and 25.2% for PERL-perovskite and IBC-perovskite, respectively.

  12. CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion.

    Science.gov (United States)

    Santillán, Orlando; Ramírez-Romero, Miguel A; Dávila, Guillermo

    2017-06-25

    Here, we present chimera assembly by plasmid recovery and restriction enzyme site insertion (CAPRRESI). CAPRRESI benefits from many strengths of the original plasmid recovery method and introduces restriction enzyme digestion to ease DNA ligation reactions (required for chimera assembly). For this protocol, users clone wildtype genes into the same plasmid (pUC18 or pUC19). After the in silico selection of amino acid sequence regions where chimeras should be assembled, users obtain all the synonym DNA sequences that encode them. Ad hoc Perl scripts enable users to determine all synonym DNA sequences. After this step, another Perl script searches for restriction enzyme sites on all synonym DNA sequences. This in silico analysis is also performed using the ampicillin resistance gene (ampR) found on pUC18/19 plasmids. Users design oligonucleotides inside synonym regions to disrupt wildtype and ampR genes by PCR. After obtaining and purifying complementary DNA fragments, restriction enzyme digestion is accomplished. Chimera assembly is achieved by ligating appropriate complementary DNA fragments. pUC18/19 vectors are selected for CAPRRESI because they offer technical advantages, such as small size (2,686 base pairs), high copy number, advantageous sequencing reaction features, and commercial availability. The usage of restriction enzymes for chimera assembly eliminates the need for DNA polymerases yielding blunt-ended products. CAPRRESI is a fast and low-cost method for fusing protein-coding genes.

  13. WebVis: a hierarchical web homepage visualizer

    Science.gov (United States)

    Renteria, Jose C.; Lodha, Suresh K.

    2000-02-01

    WebVis, the Hierarchical Web Home Page Visualizer, is a tool for managing home web pages. The user can access this tool via the WWW and obtain a hierarchical visualization of one's home web pages. WebVis is a real time interactive tool that supports many different queries on the statistics of internal files such as sizes, age, and type. In addition, statistics on embedded information such as VRML files, Java applets, images and sound files can be extracted and queried. Results of these queries are visualized using color, shape and size of different nodes of the hierarchy. The visualization assists the user in a variety of task, such as quickly finding outdated information or locate large files. WebVIs is one solution to the growing web space maintenance problem. Implementation of WebVis is realized with Perl and Java. Perl pattern matching and file handling routines are used to collect and process web space linkage information and web document information. Java utilizes the collected information to produce visualization of the web space. Java also provides WebVis with real time interactivity, while running off the WWW. Some WebVis examples of home web page visualization are presented.

  14. Technical training: Places available

    CERN Multimedia

    Monique Duval

    2004-01-01

    The number of places available may vary. Please check our Web site to find out the current availability. Places are available in the following courses: LabVIEW Intermediate I : 8 - 10.11.2004 (3 days) Instructor-led WTechT Study or Follow-up for Microsoft Applications : 9.11.2004 (morning) Outlook (Short Course III) : Meetings and Delegation : 9.11.2004 (2 hours, afternoon) LabVIEW Intermediate II : 11 & 12.11.2004 (2 days) AutoCAD 2002 - niveau 1 : 11, 12, 18, 19.11.2004 (4 jours) C++ for Particle Physicists : 15 - 19.11.2004 (6 X 3 hours sessions) Word 2003 - niveau 1 : 22 & 23.11.2004 (2 jours) Introduction à ANSYS : 23 - 26.11.2004 (4 jours) Project Planning with MS-Project : 25.11 & 2.12.2004 (2 days) Introduction to PERL 5 : 8 & 9.12.2004 (2 days) Advanced aspects of PERL 5 : 10.12.2004 (1 day) The JAVA Programming Language Level 1 : 11 & 12.1.2005 (2 days) Introduction...

  15. Comparação entre dois métodos analíticos para determinação da lignina de algumas gramíneas forrageiras Comparison between two analytical methods for determining lignin concentration of some grass forages

    Directory of Open Access Journals (Sweden)

    Romualdo Shigueo Fukushima

    1999-06-01

    Full Text Available Foram comparados dois métodos analíticos para a determinação da lignina (lignina em detergente ácido - LDA e lignina permanganato de potássio - LPer bem como para averiguar a possível relação dos teores desse componente com a digestibilidade da fibra dos seguintes fenos: andropogon (Andropogon gayanus; aveia (Avena sativa; e dois tipos de coast-cross (Cynodon dactylon, um bem fenado e outro de baixa qualidade. Os valores de LDA e LPer foram diferentes (p This work was carried out aiming to compare lignin concentration of some grass forages through two analytical methods (acid detergent lignin - ADL and permanganate lignin - PerL as well to verify a possible relationship of lignin concentration with fiber digestion of the following grass hays: andropogon (Andropogon gayanus; oats (Avena sativa; a good quality and another of poor quality coast-cross (Cynodon dactylon. Acid detergent and permanganate lignin values were different (p <= 0.05 among the hays, however PerL concentrations were consistently lower than ADL values. There were differences (p <= 0.05 among the digestibility of neutral and acid detergent fiber fractions, however a clear relationship between these values with lignin concentration could not be assessed. The data suggested that lignin concentration, taken individually, is not the only factor to explain a given value of digestibility.

  16. Balancing electrical and optical losses for efficient Si-perovskite 4-terminal solar cells with solution processed percolation electrodes.

    KAUST Repository

    Ramí rez Quiroz, Cé sar Omar; Shen, Yilei; Salvador, Michael; Forberich, Karen; Schrenker, Nadine; Spyropulos, George D.; Huemueller, Thomas; Wilkinson, Benjamin; Kirchartz, Thomas; Spiecker, Erdmann; Verlinden, Pierre J.; Zhang, Xueling; Green, Martin; Ho-Baillie, Anita Wing Yi; Brabec, Christoph J

    2018-01-01

    The unprecedented efficiency upraise of perovskite-based photovoltaics has sparked the interest in semi-transparent devices, particularly for tandem structures. Despite promising reports regarding efficiency and reduced parasitic absorption, many devices still rely on processes from the gas phase, compromising both applicability and cost factors. Here, we report all-solution perovskite solar cells with improved infrared transparency ideally suited as top-cell for efficient multi-junction device configurations. We demonstrate the functionality of Copper (I) thiocyanate as antireflective layer and selective contact between the transparent conductive oxide and the perovskite as key factor. This concept allows us to fabricate an opaque device with steady state efficiency as high as 20.1%. By employing silver nanowires with robust environmental stability as bottom electrode, we demonstrate different regimes of device performance that can be described through a classical percolation model, leading to semi-transparent solar cells with efficiencies of up to 17.1%. In conjunction with the implementation of an infrared-tuned transparent conductive oxide contact deposited on UV-fused silica, we show a full device average transmittance surpassing 84% between 800 and 1100 nm (as opposed to 77% with PEDOT:PSS as selective contact). Finally, we mechanically staked optimized perovskite devices on top of high performing PERL and IBC silicon architectures. The imputed output efficiency of the 4-terminal measured perovskite-silicon solar cell was 26.7% and 25.2% for PERL-perovskite and IBC-perovskite, respectively.

  17. The new method of modifying the hydrophobic properties of expanded perlite

    Directory of Open Access Journals (Sweden)

    Vogt Elżbieta

    2017-01-01

    Full Text Available The progressive industrialization and development of the automotive industry is the cause of the increasing demand for chemical products, especially oil products. Unfortunately, during processing, transportation or storage of these products, they get very often into the environment causing pollution. The removal of the results of accidents is still a current problem. The techniques which employ various types of sorbents deserve special attention among the several methods of eliminating the effects of pollutions. Moreover, expanded hydrophobic perlite is an interesting material among sorbents which are used on a large scale. The new method of modifying the hydrophobic properties of expanded perlite, with the use of solutions of stearic acid in organic solvents, was presented. The perlite that was used in research was produced by the PerliPol registered partnership in Bełchatów. Hydrophobic properties of the obtained materials were determined on the basis of the results achieved due to the modified film flotation method, “floating on water” test and on the basis of the value of water retention for individual samples. All grain fractions of perlite obtained hydrophobic properties which were better than or comparable to the hydrophobic properties of the HydroPerl (PerlPol commercial material used to remove petroleum product pollution. The hydrophobization process significantly improved the adsorption capacity of modified perlite to petroleum product pollution.

  18. Ruby in a nutshell a desktop quick reference

    CERN Document Server

    Matsumoto, Yukihiro

    2002-01-01

    Ruby is an absolutely pure object-oriented scripting language written in C and designed with Perl and Python capabilities in mind. While its roots are in Japan, Ruby is slowly but surely gaining ground in the US. The goal of Yukihiro Matsumoto, creator of Ruby and author of this book, is to incorporate the strengths of languages like Perl, Python, Lisp and Smalltalk. Ruby is a genuine attempt to combine the best of everything in the scripting world. Since 1993, Ruby mailing lists have been established, Web pages have formed, and a community has grown around it. The language itself is very good at text processing and is notable for its broad object orientation. Ruby is portable and runs under GNU/Linux (and other Unices) as well as DOS, MS Windows and Mac. With Ruby in a Nutshell, Matsumoto offers a practical reference to the features of this new language including the command-line options, syntax, built-in variables, functions, and many commonly used classes and modules. This guide covers the current stable ...

  19. CERN Technical Training: available places in forthcoming courses

    CERN Multimedia

    HR Department

    The following course sessions are scheduled in the framework of the 2009 CERN Technical Training Programme and places are still available. You can find the full updated Technical Training course programme in our web catalogue. Software and system technologies Developing secure software 07-DEC-09 07-DEC-09 0.5 day English JCOP - Joint PVSS-JCOP Framework 23-Nov-09 27-Nov-09 4.5 days English Oracle Database SQL Tuning 07-DEC-09 09-DEC-09 3 days English PERL 5 - Advanced Aspects 10-DEC-09 10-DEC-09 1 day English Project Development using Python 01-DEC-09 04-DEC-09 4 days English Python - Hands-on Introduction 08-DEC-09 10-DEC-09 3 days English Secure coding for Perl 26-Nov-09 26-Nov-09 1 day English Secure coding for PHP 25-Nov-09 25-Nov-09 1 day English Electronic design Advanced VHDL for FPGA Design 30-Nov-09 04-DEC-09 5 days English LabVIEW - Working efficiently with LabVIEW 8 07-DEC-09 07-DEC-09 1 day English LabVIEW Basic I with RADE introduction 30-Nov-09 02-DEC-09 3 days English LabVIEW Basics 2 03-D...

  20. Automated radiotherapy treatment plan integrity verification

    Energy Technology Data Exchange (ETDEWEB)

    Yang Deshan; Moore, Kevin L. [Department of Radiation Oncology, School of Medicine, Washington University in Saint Louis, St. Louis, Missouri 63110 (United States)

    2012-03-15

    Purpose: In our clinic, physicists spend from 15 to 60 min to verify the physical and dosimetric integrity of radiotherapy plans before presentation to radiation oncology physicians for approval. The purpose of this study was to design and implement a framework to automate as many elements of this quality control (QC) step as possible. Methods: A comprehensive computer application was developed to carry out a majority of these verification tasks in the Philips PINNACLE treatment planning system (TPS). This QC tool functions based on both PINNACLE scripting elements and PERL sub-routines. The core of this technique is the method of dynamic scripting, which involves a PERL programming module that is flexible and powerful for treatment plan data handling. Run-time plan data are collected, saved into temporary files, and analyzed against standard values and predefined logical rules. The results were summarized in a hypertext markup language (HTML) report that is displayed to the user. Results: This tool has been in clinical use for over a year. The occurrence frequency of technical problems, which would cause delays and suboptimal plans, has been reduced since clinical implementation. Conclusions: In addition to drastically reducing the set of human-driven logical comparisons, this QC tool also accomplished some tasks that are otherwise either quite laborious or impractical for humans to verify, e.g., identifying conflicts amongst IMRT optimization objectives.

  1. Automated radiotherapy treatment plan integrity verification

    International Nuclear Information System (INIS)

    Yang Deshan; Moore, Kevin L.

    2012-01-01

    Purpose: In our clinic, physicists spend from 15 to 60 min to verify the physical and dosimetric integrity of radiotherapy plans before presentation to radiation oncology physicians for approval. The purpose of this study was to design and implement a framework to automate as many elements of this quality control (QC) step as possible. Methods: A comprehensive computer application was developed to carry out a majority of these verification tasks in the Philips PINNACLE treatment planning system (TPS). This QC tool functions based on both PINNACLE scripting elements and PERL sub-routines. The core of this technique is the method of dynamic scripting, which involves a PERL programming module that is flexible and powerful for treatment plan data handling. Run-time plan data are collected, saved into temporary files, and analyzed against standard values and predefined logical rules. The results were summarized in a hypertext markup language (HTML) report that is displayed to the user. Results: This tool has been in clinical use for over a year. The occurrence frequency of technical problems, which would cause delays and suboptimal plans, has been reduced since clinical implementation. Conclusions: In addition to drastically reducing the set of human-driven logical comparisons, this QC tool also accomplished some tasks that are otherwise either quite laborious or impractical for humans to verify, e.g., identifying conflicts amongst IMRT optimization objectives.

  2. Spatially resolved analysis and minimization of resistive losses in high-efficiency Si solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Altermatt, P.P.; Wang, A.; Zhao, J.; Robinson, S.J.; Bowden, S.; Green, M.A. [New South Wales Univ., Kensington, NSW (Australia). Centre for Photovoltaic Devices and Systems; Heiser, G. [New South Wales Univ., Sydney, NSW (Australia). School of Computer Science and Engineering; Aberle, A.G. [Institut fuer Solarenergieforschung (ISFH), Emmerthal (Germany)

    1996-11-01

    This paper presents an improved method for measuring the total lumped series resistance (R{sub s}) of high-efficiency solar cells. Since this method greatly minimizes the influence of non-linear recombination processes on the measured R{sub s} values, it is possible to determine R{sub s} as a function of external current density over a wide range of illumination levels with a significantly improved level of accuracy. This paper furthermore explains how resistive losses in the emitter, the base, the metal/silicon contacts and the front metal grid can be separately determined by combining measurements and multi-dimensional numerical simulations. A novel combination of device simulation and circuit simulation is introduced in order to simulate complete 2 x 2 cm s sq. P:ERL (`passivated emitter and rear locally-diffused`) silicon solar cells. These computer simulations provide improved insight into the dynamics of resistive losses, and thus allow new strategies for the optimization of resistive losses to be developed. The predictions have been experimentally verified with PERL cells, whose resistive losses were reduced to approximately half of their previous values, contributing to a new efficiency world record (24.0%) for silicon solar cells under terrestrial illumination. The measurement techniques and optimization strategies presented here can be applied to most other types of solar cells, and to materials other than silicon. (Author)

  3. A comparison of common programming languages used in bioinformatics.

    Science.gov (United States)

    Fourment, Mathieu; Gillings, Michael R

    2008-02-05

    The performance of different programming languages has previously been benchmarked using abstract mathematical algorithms, but not using standard bioinformatics algorithms. We compared the memory usage and speed of execution for three standard bioinformatics methods, implemented in programs using one of six different programming languages. Programs for the Sellers algorithm, the Neighbor-Joining tree construction algorithm and an algorithm for parsing BLAST file outputs were implemented in C, C++, C#, Java, Perl and Python. Implementations in C and C++ were fastest and used the least memory. Programs in these languages generally contained more lines of code. Java and C# appeared to be a compromise between the flexibility of Perl and Python and the fast performance of C and C++. The relative performance of the tested languages did not change from Windows to Linux and no clear evidence of a faster operating system was found. Source code and additional information are available from http://www.bioinformatics.org/benchmark/. This benchmark provides a comparison of six commonly used programming languages under two different operating systems. The overall comparison shows that a developer should choose an appropriate language carefully, taking into account the performance expected and the library availability for each language.

  4. Dynamic Subcellular Localization of Iron during Embryo Development in Brassicaceae Seeds

    Directory of Open Access Journals (Sweden)

    Miguel A. Ibeas

    2017-12-01

    Full Text Available Iron is an essential micronutrient for plants. Little is know about how iron is loaded in embryo during seed development. In this article we used Perls/DAB staining in order to reveal iron localization at the cellular and subcellular levels in different Brassicaceae seed species. In dry seeds of Brassica napus, Nasturtium officinale, Lepidium sativum, Camelina sativa, and Brassica oleracea iron localizes in vacuoles of cells surrounding provasculature in cotyledons and hypocotyl. Using B. napus and N. officinale as model plants we determined where iron localizes during seed development. Our results indicate that iron is not detectable by Perls/DAB staining in heart stage embryo cells. Interestingly, at torpedo development stage iron localizes in nuclei of different cells type, including integument, free cell endosperm and almost all embryo cells. Later, iron is detected in cytoplasmic structures in different embryo cell types. Our results indicate that iron accumulates in nuclei in specific stages of embryo maturation before to be localized in vacuoles of cells surrounding provasculature in mature seeds.

  5. NeisseriaBase: a specialised Neisseria genomic resource and analysis platform

    Directory of Open Access Journals (Sweden)

    Wenning Zheng

    2016-03-01

    Full Text Available Background. The gram-negative Neisseria is associated with two of the most potent human epidemic diseases: meningococcal meningitis and gonorrhoea. In both cases, disease is caused by bacteria colonizing human mucosal membrane surfaces. Overall, the genus shows great diversity and genetic variation mainly due to its ability to acquire and incorporate genetic material from a diverse range of sources through horizontal gene transfer. Although a number of databases exist for the Neisseria genomes, they are mostly focused on the pathogenic species. In this present study we present the freely available NeisseriaBase, a database dedicated to the genus Neisseria encompassing the complete and draft genomes of 15 pathogenic and commensal Neisseria species. Methods. The genomic data were retrieved from National Center for Biotechnology Information (NCBI and annotated using the RAST server which were then stored into the MySQL database. The protein-coding genes were further analyzed to obtain information such as calculation of GC content (%, predicted hydrophobicity and molecular weight (Da using in-house Perl scripts. The web application was developed following the secure four-tier web application architecture: (1 client workstation, (2 web server, (3 application server, and (4 database server. The web interface was constructed using PHP, JavaScript, jQuery, AJAX and CSS, utilizing the model-view-controller (MVC framework. The in-house developed bioinformatics tools implemented in NeisseraBase were developed using Python, Perl, BioPerl and R languages. Results. Currently, NeisseriaBase houses 603,500 Coding Sequences (CDSs, 16,071 RNAs and 13,119 tRNA genes from 227 Neisseria genomes. The database is equipped with interactive web interfaces. Incorporation of the JBrowse genome browser in the database enables fast and smooth browsing of Neisseria genomes. NeisseriaBase includes the standard BLAST program to facilitate homology searching, and for Virulence

  6. NeisseriaBase: a specialised Neisseria genomic resource and analysis platform.

    Science.gov (United States)

    Zheng, Wenning; Mutha, Naresh V R; Heydari, Hamed; Dutta, Avirup; Siow, Cheuk Chuen; Jakubovics, Nicholas S; Wee, Wei Yee; Tan, Shi Yang; Ang, Mia Yang; Wong, Guat Jah; Choo, Siew Woh

    2016-01-01

    Background. The gram-negative Neisseria is associated with two of the most potent human epidemic diseases: meningococcal meningitis and gonorrhoea. In both cases, disease is caused by bacteria colonizing human mucosal membrane surfaces. Overall, the genus shows great diversity and genetic variation mainly due to its ability to acquire and incorporate genetic material from a diverse range of sources through horizontal gene transfer. Although a number of databases exist for the Neisseria genomes, they are mostly focused on the pathogenic species. In this present study we present the freely available NeisseriaBase, a database dedicated to the genus Neisseria encompassing the complete and draft genomes of 15 pathogenic and commensal Neisseria species. Methods. The genomic data were retrieved from National Center for Biotechnology Information (NCBI) and annotated using the RAST server which were then stored into the MySQL database. The protein-coding genes were further analyzed to obtain information such as calculation of GC content (%), predicted hydrophobicity and molecular weight (Da) using in-house Perl scripts. The web application was developed following the secure four-tier web application architecture: (1) client workstation, (2) web server, (3) application server, and (4) database server. The web interface was constructed using PHP, JavaScript, jQuery, AJAX and CSS, utilizing the model-view-controller (MVC) framework. The in-house developed bioinformatics tools implemented in NeisseraBase were developed using Python, Perl, BioPerl and R languages. Results. Currently, NeisseriaBase houses 603,500 Coding Sequences (CDSs), 16,071 RNAs and 13,119 tRNA genes from 227 Neisseria genomes. The database is equipped with interactive web interfaces. Incorporation of the JBrowse genome browser in the database enables fast and smooth browsing of Neisseria genomes. NeisseriaBase includes the standard BLAST program to facilitate homology searching, and for Virulence Factor

  7. Resources for comparing the speed and performance of medical autocoders

    Directory of Open Access Journals (Sweden)

    Berman Jules J

    2004-06-01

    Full Text Available Abstract Background Concept indexing is a popular method for characterizing medical text, and is one of the most important early steps in many data mining efforts. Concept indexing differs from simple word or phrase indexing because concepts are typically represented by a nomenclature code that binds a medical concept to all equivalent representations. A concept search on the term renal cell carcinoma would be expected to find occurrences of hypernephroma, and renal carcinoma (concept equivalents. The purpose of this study is to provide freely available resources to compare speed and performance among different autocoders. These tools consist of: 1 a public domain autocoder written in Perl (a free and open source programming language that installs on any operating system; 2 a nomenclature database derived from the unencumbered subset of the publicly available Unified Medical Language System; 3 a large corpus of autocoded output derived from a publicly available medical text. Methods A simple lexical autocoder was written that parses plain-text into a listing of all 1,2,3, and 4-word strings contained in text, assigning a nomenclature code for text strings that match terms in the nomenclature. The nomenclature used is the unencumbered subset of the 2003 Unified Medical Language System (UMLS. The unencumbered subset of UMLS was reduced to exclude homonymous one-word terms and proper names, resulting in a term/code data dictionary containing about a half million medical terms. The Online Mendelian Inheritance in Man (OMIM, a 92+ Megabyte publicly available medical opus, was used as sample medical text for the autocoder. Results The autocoding Perl script is remarkably short, consisting of just 38 command lines. The 92+ Megabyte OMIM file was completely autocoded in 869 seconds on a 2.4 GHz processor (less than 10 seconds per Megabyte of text. The autocoded output file (9,540,442 bytes contains 367,963 coded terms from OMIM and is distributed with

  8. Regional strategy tested in Caribbean.

    Science.gov (United States)

    1984-01-01

    Barbados, St. Vincent, and St. Lucia have joined forces in the world's 1st regional Contraceptive Social Marketing (CSM) effort -- the Caribbean CSM. The Barbados Family Planning Association (BFPS) is overseeing the operation, which begins selling 2 contraceptive pills and a condom in early February. Costs and start-up times were shaved by adopting brand names and advertising materials from Jamaica's highly successful CSM project. Jamaica's popular "Panther" condom and "Perle" oral contraceptive (OC) are being used by the Caribbean CSM project. Perle's 9-year-old package has been redesigned and the Caribbean CSM project also is selling a 2nd, low-dose version called "Perle-LD." The products are manufactured in the US by Syntex as Noriday and Norminest, respectively. But the regional approach's financial gains also had a debit side, most notably a tripling of bureaucratic procedures. Part of project difficulties stem from differences among the 3 Caribbean countries. While sharing a common cultural heritage, St. Lucians speak a patois dialect in addition to the English prevalent on the other islands. The biggest hurdle was overcoming an economic disparity between Barbados and its less affluent neighbors, St. Vincent and St. Lucia. The CSM project decided to try a 2-tier product pricing strategy. In US currency, prices run $1.75 per cycle for both OCs on Barbados, but $1.26 on St. Vincent and St. Lucia. A Panther 3-pack costs 75 cents on Barbados and 42 cents on the othe 2 islands. The project is being promoted with generic family planning media advertisements. The project also has held physician orientation seminars on each island. The pilot program will be accompanied by retailer training seminars. In addition the project may introduce a spermicidal foaming tablet, once the US Food and Drug Administration approvs a new American-made product. The unique Caribbean CSM project may spread an idea as potent as the family planning message. Its success could transmit the

  9. Monitoring solar energetic particles with an armada of European spacecraft and the new automated SEPF (Solar Energetic Proton Fluxes) Tool

    Science.gov (United States)

    Sandberg, I.; Daglis, I. A.; Anastasiadis, A.; Balasis, G.; Georgoulis, M.; Nieminen, P.; Evans, H.; Daly, E.

    2012-01-01

    Solar energetic particles (SEPs) observed in interplanetary medium consist of electrons, protons, alpha particles and heavier ions (up to Fe), with energies from dozens of keVs to a few GeVs. SEP events, or SEPEs, are particle flux enhancements from background level ( 30 MeV. The main part of SEPEs results from the acceleration of particles either by solar flares and/or by interplanetary shocks driven by Coronal Mass Ejections (CMEs); these accelerated particles propagate through the heliosphere, traveling along the interplanetary magnetic field (IMF). SEPEs show significant variability from one event to another and are an important part of space weather, because they pose a serious health risk to humans in space and a serious radiation hazard for the spacecraft hardware which may lead to severe damages. As a consequence, engineering models, observations and theoretical investigations related to the high energy particle environment is a priority issue for both robotic and manned space missions. The European Space Agency operates the Standard Radiation Environment Monitor (SREM) on-board six spacecraft: Proba-1, INTEGRAL, Rosetta, Giove-B, Herschel and Planck, which measures high-energy protons and electrons with a fair angular and spectral resolution. The fact that several SREM units operate in different orbits provides a unique chance for comparative studies of the radiation environment based on multiple data gathered by identical detectors. Furthermore, the radiation environment monitoring by the SREM unit onboard Rosetta may reveal unknown characteristics of SEPEs properties given the fact that the majority of the available radiation data and models only refer to 1AU solar distances. The Institute for Space Applications and Remote Sensing of the National Observatory of Athens (ISARS/NOA) has developed and validated a novel method to obtain flux spectra from SREM count rates. Using this method and by conducting detailed scientific studies we have showed in

  10. Development of District-Based Mineral-Hazards Maps for Highways in California

    Science.gov (United States)

    Higgins, C. T.; Churchill, R. K.; Fonseca, M. C.

    2011-12-01

    The California Geological Survey (CGS) currently is developing a series of unpublished maps for the California Department of Transportation (Caltrans) that shows potential for mineral hazards within each of the twelve highway districts administered by that agency. Where present along or near highway corridors, such hazards may pose problems for human health and safety or the environment. Prepared at a scale of 1:250,000, the maps are designed as initial screening tools for Caltrans staff to use to improve planning of activities that involve new construction projects, routine maintenance of highways, and emergency removal of debris deposited on roads by natural processes. Although the basic presentation of each type of thematic map in the series is the same, some customization and focus are allowed for each district because each has unique issues concerning potential for mineral hazards. The maps display many natural and man-made features that may be potential sources of mineral hazards within each district. Features compiled and evaluated under our definition of "mineral hazards" are: 1) naturally-occurring asbestos (NOA); 2) natural occurrences of various regulated metals (Ag, Ba, Be, Cd, Co, Cr, Cu, Hg, Mo, Ni, Pb, Tl, V, Zn) and metalloids (As, Sb, Se) as well as other pertinent metals, such as Mn and U; 3) faults, which can be sites of increased potential for certain types of mineralization, such as NOA; 4) mines and prospects, which can be sources of anomalous concentrations of metals as well as ore-processing chemicals; 5) natural petroleum features, such as oil and natural-gas seeps; 6) natural geothermal features, such as thermal springs and fumaroles; and 7) oil, natural-gas, and geothermal wells. Because of their greater potential as sources of mineral hazards, localities designated on the maps as "areas of potential mineralogical concern" are of particular interest to Caltrans. Examples include significant mining districts, such as New Almaden (Hg) near

  11. The BEYOND center of excellence for the effective exploitation of satellite time series towards natural disasters monitoring and assessment

    Science.gov (United States)

    Kontoes, Charalampos; Papoutsis, Ioannis; Amiridis, Vassilis; Balasis, George; Keramitsoglou, Iphigenia; Herekakis, Themistocles; Christia, Eleni

    2014-05-01

    BEYOND project (2013-2016, 2.3Meuro) funded under the FP7-REGPOT scheme is an initiative which aims to build a Centre of Excellence for Earth Observation (EO) based monitoring of natural disasters in south-eastern Europe (http://beyond-eocenter.eu/), established at the National Observatory of Athens (NOA). The project focuses on capacity building on top of the existing infrastructure, aiming at unlocking the institute's potential through the systematic interaction with high-profile partners across Europe, and at consolidating state-of-the-art equipment and technological know-how that will allow sustainable cutting-edge interdisciplinary research to take place with an impact on the regional and European socioeconomic welfare. The vision is to set up innovative integrated observational solutions to allow a multitude of space borne and ground-based monitoring networks to operate in a complementary and cooperative manner, create archives and databases of long series of observations and higher level products, and make these available for exploitation with the involvement of stakeholders. In BEYOND critical infrastructural components are being procured for fostering access, use, retrieval and analysis of long EO data series and products. In this framework NOA has initiated activities for the development, installation and operation of important acquisition facilities and hardware modules, including space based observational infrastructures as the X-/L-band acquisition station for receiving EOS Aqua/Terra, NPP, JPSS, NOAA, Metop, Feng Yun data in real time, the setting up of an ESA's Mirror Site of Sentinel missions to be operable from 2014 onwards, an advanced Raman Lidar portable station, a spectrometer facility, several ground magnetometer stations. All these are expected to work in synergy with the existing capacity resources and observational networks including the MSG/SEVIRI acquisition station, nationwide seismographic, GPS, meteo and atmospheric networks. The

  12. When the Web meets the cell: using personalized PageRank for analyzing protein interaction networks.

    Science.gov (United States)

    Iván, Gábor; Grolmusz, Vince

    2011-02-01

    Enormous and constantly increasing quantity of biological information is represented in metabolic and in protein interaction network databases. Most of these data are freely accessible through large public depositories. The robust analysis of these resources needs novel technologies, being developed today. Here we demonstrate a technique, originating from the PageRank computation for the World Wide Web, for analyzing large interaction networks. The method is fast, scalable and robust, and its capabilities are demonstrated on metabolic network data of the tuberculosis bacterium and the proteomics analysis of the blood of melanoma patients. The Perl script for computing the personalized PageRank in protein networks is available for non-profit research applications (together with sample input files) at the address: http://uratim.com/pp.zip.

  13. The Ensembl Web site: mechanics of a genome browser.

    Science.gov (United States)

    Stalker, James; Gibbins, Brian; Meidl, Patrick; Smith, James; Spooner, William; Hotz, Hans-Rudolf; Cox, Antony V

    2004-05-01

    The Ensembl Web site (http://www.ensembl.org/) is the principal user interface to the data of the Ensembl project, and currently serves >500,000 pages (approximately 2.5 million hits) per week, providing access to >80 GB (gigabyte) of data to users in more than 80 countries. Built atop an open-source platform comprising Apache/mod_perl and the MySQL relational database management system, it is modular, extensible, and freely available. It is being actively reused and extended in several different projects, and has been downloaded and installed in companies and academic institutions worldwide. Here, we describe some of the technical features of the site, with particular reference to its dynamic configuration that enables it to handle disparate data from multiple species.

  14. CERN in the park

    CERN Multimedia

    2002-01-01

    CERN will be the centre of debate at a 'Café scientifique' on Monday 29 April. The aim of the Cafés scientifiques, which are organised by the association of Bancs Publics, is to kindle discussion between ordinary people and specialists in a scientific field. This Monday, Maurice Bourquin, President of the CERN Council, Hans Hoffmann, Director of Technology Transfer and Scientific Computing at CERN, Gilbert Guignard, a physicist at CERN, and Ruhal Floris, who teaches mathematical didactics at the University of Geneva, will explain the usefulness and contributions to science of the world's biggest laboratory for particle physics. What is CERN for? Monday 29 April at 18.30 Musée d'histoire des sciences, Geneva (in the park Perle du Lac) Entry free Wine and buffet after the discussion

  15. [The development and evaluation of software to verify diagnostic accuracy].

    Science.gov (United States)

    Jensen, Rodrigo; de Moraes Lopes, Maria Helena Baena; Silveira, Paulo Sérgio Panse; Ortega, Neli Regina Siqueira

    2012-02-01

    This article describes the development and evaluation of software that verifies the accuracy of diagnoses made by nursing students. The software was based on a model that uses fuzzy logic concepts, including PERL, the MySQL database for Internet accessibility, and the NANDA-I 2007-2008 classification system. The software was evaluated in terms of its technical quality and usability through specific instruments. The activity proposed in the software involves four stages in which students establish the relationship values between nursing diagnoses, defining characteristics/risk factors and clinical cases. The relationship values determined by students are compared to those of specialists, generating performance scores for the students. In the evaluation, the software demonstrated satisfactory outcomes regarding the technical quality and, according to the students, helped in their learning and may become an educational tool to teach the process of nursing diagnosis.

  16. Webmail: an Automated Web Publishing System

    Science.gov (United States)

    Bell, David

    A system for publishing frequently updated information to the World Wide Web will be described. Many documents now hosted by the NOAO Web server require timely posting and frequent updates, but need only minor changes in markup or are in a standard format requiring only conversion to HTML. These include information from outside the organization, such as electronic bulletins, and a number of internal reports, both human and machine generated. Webmail uses procmail and Perl scripts to process incoming email messages in a variety of ways. This processing may include wrapping or conversion to HTML, posting to the Web or internal newsgroups, updating search indices or links on related pages, and sending email notification of the new pages to interested parties. The Webmail system has been in use at NOAO since early 1997 and has steadily grown to include fourteen recipes that together handle about fifty messages per week.

  17. PLACES AVAILABLE

    CERN Multimedia

    Technical Training; Tel. 74924

    2001-01-01

    Places are available in the following courses: Introduction to Perl 5 : 2 - 3.7.01 (2 days) Introduction to Databases :  3 - 4.7.01 (2 days) JAVA programming language Level 2 : 4 - 6.7.01 (3 days) Enterprise JavaBeans :  9 - 11.7.01 (3 days) Design Patterns :  10 - 12.7.01 (3 days) C++ for Particle Physicists :  23 - 27.7.01 (6 3-hour lectures) If you wish to participate in one of these courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at : http://www.cern.ch/Training/ or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt.

  18. snpTree - a web-server to identify and construct SNP trees from whole genome sequence data

    DEFF Research Database (Denmark)

    Leekitcharoenphon, Pimlapas; Kaas, Rolf Sommer; Thomsen, Martin Christen Frølund

    2012-01-01

    identify SNPs and construct phylogenetic trees from WGS as well as from assembled genomes or contigs. WGS data in fastq format are aligned to reference genomes by BWA while contigs in fasta format are processed by Nucmer. SNPs are concatenated based on position on reference genome and a tree is constructed...... to differentiate and classify isolates. One of the successfully and broadly used methods is analysis of single nucletide polymorphisms (SNPs). Currently, there are different tools and methods to identify SNPs including various options and cut-off values. Furthermore, all current methods require bioinformatic...... skills. Thus, we lack a standard and simple automatic tool to determine SNPs and construct phylogenetic tree from WGS data. Results Here we introduce snpTree, a server for online-automatic SNPs analysis. This tool is composed of different SNPs analysis suites, perl and python scripts. snpTree can...

  19. Managing Library IT Workflow with Bugzilla

    Directory of Open Access Journals (Sweden)

    Nina McHale

    2010-09-01

    Full Text Available Prior to September 2008, all technology issues at the University of Colorado Denver's Auraria Library were reported to a dedicated departmental phone line. A variety of staff changes necessitated a more formal means of tracking, delegating, and resolving reported issues, and the department turned to Bugzilla, an open source bug tracking application designed by Mozilla.org developers. While designed with software development bug tracking in mind, Bugzilla can be easily customized and modified to serve as an IT ticketing system. Twenty-three months and over 2300 trouble tickets later, Auraria's IT department workflow is much smoother and more efficient. This article includes two Perl Template Toolkit code samples for customized Bugzilla screens for its use in a library environment; readers will be able to easily replicate the project in their own environments.

  20. ViralEpi v1.0: a high-throughput spectrum of viral epigenomic methylation profiles from diverse diseases.

    Science.gov (United States)

    Khan, Mohd Shoaib; Gupta, Amit Kumar; Kumar, Manoj

    2016-01-01

    To develop a computational resource for viral epigenomic methylation profiles from diverse diseases. Methylation patterns of Epstein-Barr virus and hepatitis B virus genomic regions are provided as web platform developed using open source Linux-Apache-MySQL-PHP (LAMP) bundle: programming and scripting languages, that is, HTML, JavaScript and PERL. A comprehensive and integrated web resource ViralEpi v1.0 is developed providing well-organized compendium of methylation events and statistical analysis associated with several diseases. Additionally, it also facilitates 'Viral EpiGenome Browser' for user-affable browsing experience using JavaScript-based JBrowse. This web resource would be helpful for research community engaged in studying epigenetic biomarkers for appropriate prognosis and diagnosis of diseases and its various stages.

  1. Generating and Executing Complex Natural Language Queries across Linked Data.

    Science.gov (United States)

    Hamon, Thierry; Mougin, Fleur; Grabar, Natalia

    2015-01-01

    With the recent and intensive research in the biomedical area, the knowledge accumulated is disseminated through various knowledge bases. Links between these knowledge bases are needed in order to use them jointly. Linked Data, SPARQL language, and interfaces in Natural Language question-answering provide interesting solutions for querying such knowledge bases. We propose a method for translating natural language questions in SPARQL queries. We use Natural Language Processing tools, semantic resources, and the RDF triples description. The method is designed on 50 questions over 3 biomedical knowledge bases, and evaluated on 27 questions. It achieves 0.78 F-measure on the test set. The method for translating natural language questions into SPARQL queries is implemented as Perl module available at http://search.cpan.org/ thhamon/RDF-NLP-SPARQLQuery.

  2. The Aesthetics of Coding

    DEFF Research Database (Denmark)

    Andersen, Christian Ulrik

    2007-01-01

    Computer art is often associated with computer-generated expressions (digitally manipulated audio/images in music, video, stage design, media facades, etc.). In recent computer art, however, the code-text itself – not the generated output – has become the artwork (Perl Poetry, ASCII Art, obfuscated...... code, etc.). The presentation relates this artistic fascination of code to a media critique expressed by Florian Cramer, claiming that the graphical interface represents a media separation (of text/code and image) causing alienation to the computer’s materiality. Cramer is thus the voice of a new ‘code...... avant-garde’. In line with Cramer, the artists Alex McLean and Adrian Ward (aka Slub) declare: “art-oriented programming needs to acknowledge the conditions of its own making – its poesis.” By analysing the Live Coding performances of Slub (where they program computer music live), the presentation...

  3. A night with good vibrations

    CERN Multimedia

    2002-01-01

    For its third edition, the Museum d'histoire des sciences invites you to a Science Night under the banner of waves and undulations. Scientists, artists and storytellers from more than forty institutes and local or regional associations will show in only one weekend that waves and undulations form an integral part of our daily environment. Telephones, televisions, radios, irons, lighting, music, sun rays, stars, rainbows, earthquakes and other natural phenomena - all produce, emit or receive waves or undulations. The visitors attending the Night will be able to get in contact with the nature of waves through interactive exhibitions on sound and light and through hands-on demonstrations arranged around the Bartholoni villa and in the Park of the Perle du lac. An amusing and distracting way to familiarize yourself with the concepts of wavelength, frequency and interference lengths... In addition to the stands, the Night will offer many other activities: reconstructions of critical experiments, scientific consu...

  4. An in silico pipeline to filter the Toxoplasma gondii proteome for proteins that could traffic to the host cell nucleus and influence host cell epigenetic regulation.

    Science.gov (United States)

    Syn, Genevieve; Blackwell, Jenefer M; Jamieson, Sarra E; Francis, Richard W

    2018-01-01

    Toxoplasma gondii uses epigenetic mechanisms to regulate both endogenous and host cell gene expression. To identify genes with putative epigenetic functions, we developed an in silico pipeline to interrogate the T. gondii proteome of 8313 proteins. Step 1 employs PredictNLS and NucPred to identify genes predicted to target eukaryotic nuclei. Step 2 uses GOLink to identify proteins of epigenetic function based on Gene Ontology terms. This resulted in 611 putative nuclear localised proteins with predicted epigenetic functions. Step 3 filtered for secretory proteins using SignalP, SecretomeP, and experimental data. This identified 57 of the 611 putative epigenetic proteins as likely to be secreted. The pipeline is freely available online, uses open access tools and software with user-friendly Perl scripts to automate and manage the results, and is readily adaptable to undertake any such in silico search for genes contributing to particular functions.

  5. nuMap: a web platform for accurate prediction of nucleosome positioning.

    Science.gov (United States)

    Alharbi, Bader A; Alshammari, Thamir H; Felton, Nathan L; Zhurkin, Victor B; Cui, Feng

    2014-10-01

    Nucleosome positioning is critical for gene expression and of major biological interest. The high cost of experimentally mapping nucleosomal arrangement signifies the need for computational approaches to predict nucleosome positions at high resolution. Here, we present a web-based application to fulfill this need by implementing two models, YR and W/S schemes, for the translational and rotational positioning of nucleosomes, respectively. Our methods are based on sequence-dependent anisotropic bending that dictates how DNA is wrapped around a histone octamer. This application allows users to specify a number of options such as schemes and parameters for threading calculation and provides multiple layout formats. The nuMap is implemented in Java/Perl/MySQL and is freely available for public use at http://numap.rit.edu. The user manual, implementation notes, description of the methodology and examples are available at the site. Copyright © 2014 The Authors. Production and hosting by Elsevier Ltd.. All rights reserved.

  6. ISRNA: an integrative online toolkit for short reads from high-throughput sequencing data.

    Science.gov (United States)

    Luo, Guan-Zheng; Yang, Wei; Ma, Ying-Ke; Wang, Xiu-Jie

    2014-02-01

    Integrative Short Reads NAvigator (ISRNA) is an online toolkit for analyzing high-throughput small RNA sequencing data. Besides the high-speed genome mapping function, ISRNA provides statistics for genomic location, length distribution and nucleotide composition bias analysis of sequence reads. Number of reads mapped to known microRNAs and other classes of short non-coding RNAs, coverage of short reads on genes, expression abundance of sequence reads as well as some other analysis functions are also supported. The versatile search functions enable users to select sequence reads according to their sub-sequences, expression abundance, genomic location, relationship to genes, etc. A specialized genome browser is integrated to visualize the genomic distribution of short reads. ISRNA also supports management and comparison among multiple datasets. ISRNA is implemented in Java/C++/Perl/MySQL and can be freely accessed at http://omicslab.genetics.ac.cn/ISRNA/.

  7. ADASS Web Database XML Project

    Science.gov (United States)

    Barg, M. I.; Stobie, E. B.; Ferro, A. J.; O'Neil, E. J.

    In the spring of 2000, at the request of the ADASS Program Organizing Committee (POC), we began organizing information from previous ADASS conferences in an effort to create a centralized database. The beginnings of this database originated from data (invited speakers, participants, papers, etc.) extracted from HyperText Markup Language (HTML) documents from past ADASS host sites. Unfortunately, not all HTML documents are well formed and parsing them proved to be an iterative process. It was evident at the beginning that if these Web documents were organized in a standardized way, such as XML (Extensible Markup Language), the processing of this information across the Web could be automated, more efficient, and less error prone. This paper will briefly review the many programming tools available for processing XML, including Java, Perl and Python, and will explore the mapping of relational data from our MySQL database to XML.

  8. nuMap: A Web Platform for Accurate Prediction of Nucleosome Positioning

    Directory of Open Access Journals (Sweden)

    Bader A. Alharbi

    2014-10-01

    Full Text Available Nucleosome positioning is critical for gene expression and of major biological interest. The high cost of experimentally mapping nucleosomal arrangement signifies the need for computational approaches to predict nucleosome positions at high resolution. Here, we present a web-based application to fulfill this need by implementing two models, YR and W/S schemes, for the translational and rotational positioning of nucleosomes, respectively. Our methods are based on sequence-dependent anisotropic bending that dictates how DNA is wrapped around a histone octamer. This application allows users to specify a number of options such as schemes and parameters for threading calculation and provides multiple layout formats. The nuMap is implemented in Java/Perl/MySQL and is freely available for public use at http://numap.rit.edu. The user manual, implementation notes, description of the methodology and examples are available at the site.

  9. Iron and ferritin accumulate in separate cellular locations in Phaseolus seeds

    DEFF Research Database (Denmark)

    Cvitanich, Cristina; Przybylowicz, Wojciech J; Urbanski, Dorian Fabian

    2010-01-01

    and will assist in the production of staples with increased bioavailable iron. Results Here we reveal the distribution of iron in seeds of three Phaseolus species including thirteen genotypes of P. vulgaris, P. coccineus, and P. lunatus. We showed that high concentrations of iron accumulate in cells surrounding...... the provascular tissue of P. vulgaris and P. coccineus seeds. Using the Perls' Prussian blue method, we were able to detect iron in the cytoplasm of epidermal cells, cells near the epidermis, and cells surrounding the provascular tissue. In contrast, the protein ferritin that has been suggested as the major iron...... to P. vulgaris and P. coccineus, we did not observe iron accumulation in the cells surrounding the provascular tissues of P. lunatus cotyledons. A novel iron-rich genotype, NUA35, with a high concentration of iron both in the seed coat and cotyledons was bred from a cross between an Andean...

  10. The genome BLASTatlas - a GeneWiz extension for visualization of whole-genome homology

    DEFF Research Database (Denmark)

    Hallin, Peter Fischer; Binnewies, Tim Terence; Ussery, David

    2008-01-01

    ://www.cbs.dtu.dk/ws/BLASTatlas), where programming examples are available in Perl. By providing an interoperable method to carry out whole genome visualization of homology, this service offers bioinformaticians as well as biologists an easy-to-adopt workflow that can be directly called from the programming language of the user, hence......The development of fast and inexpensive methods for sequencing bacterial genomes has led to a wealth of data, often with many genomes being sequenced of the same species or closely related organisms. Thus, there is a need for visualization methods that will allow easy comparison of many sequenced...... genomes to a defined reference strain. The BLASTatlas is one such tool that is useful for mapping and visualizing whole genome homology of genes and proteins within a reference strain compared to other strains or species of one or more prokaryotic organisms. We provide examples of BLASTatlases, including...

  11. Production Experiences with the Cray-Enabled TORQUE Resource Manager

    Energy Technology Data Exchange (ETDEWEB)

    Ezell, Matthew A [ORNL; Maxwell, Don E [ORNL; Beer, David [Adaptive Computing

    2013-01-01

    High performance computing resources utilize batch systems to manage the user workload. Cray systems are uniquely different from typical clusters due to Cray s Application Level Placement Scheduler (ALPS). ALPS manages binary transfer, job launch and monitoring, and error handling. Batch systems require special support to integrate with ALPS using an XML protocol called BASIL. Previous versions of Adaptive Computing s TORQUE and Moab batch suite integrated with ALPS from within Moab, using PERL scripts to interface with BASIL. This would occasionally lead to problems when all the components would become unsynchronized. Version 4.1 of the TORQUE Resource Manager introduced new features that allow it to directly integrate with ALPS using BASIL. This paper describes production experiences at Oak Ridge National Laboratory using the new TORQUE software versions, as well as ongoing and future work to improve TORQUE.

  12. Fourteen polymorphic microsatellite markers for the fungal banana pathogen Mycosphaerella fijiensis.

    Science.gov (United States)

    Yang, Bao Jun; Zhong, Shao Bin

    2008-07-01

    Fourteen polymorphic microsatellite markers were developed for Mycosphaerella fijiensis, a fungus causing the black sigatoka disease in banana. The sequenced genome of M. fijiensis was screened for sequences with single sequence repeats (SSRs) using a Perl script. Fourteen SSR loci, evaluated on 48 M. fijiensis isolates from Hawaii, were identified to be highly polymorphic. These markers revealed two to 19 alleles, with an average of 6.43 alleles per locus. The estimated gene diversity ranged from 0.091 to 0.930 across the 14 microsatellite loci. The SSR markers developed would be useful for population genetics studies of M. fijiensis. © 2008 The Authors. Journal compilation © 2008 Blackwell Publishing Ltd.

  13. A night without limits for science

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    On 10 and 11 July some 400 scientists came down to Geneva's Perle du Lac park to meet the public for the Nuit de la Science.   One of the many attractions at the Nuit de la Science. The theme of this year's event, now in its eighth year, was "Extremes and Limits". Numerous attractions including stands, workshops, mini-conferences and plays were set up in the park, all with the aim of conveying their passion for research and thirst for knowledge to the visitors. Several CERN guides were on hand to tell the public about that machine of the extreme, the LHC. CERN was also represented on the stand of the Réseau romand science & cité. For more information, clic here.      

  14. For one weekend, CERN takes a stand at Geneva’s Nuit de la science

    CERN Multimedia

    2008-01-01

    CERN took part in the seventh year of the Nuit de la science on 5-6 July dedicated to the theme of Time. Some 30 000 visitors filed through the 52 stands set up around the Perle du Lac park. The Geneva ‘Musée d’histoire des sciences’, the heart of the event (Copyright MHS - Photo: Philippe Wagneur). Michel Boffard, a CERN guide, makes a simple experiment to show super-conductivity (Photo: Claude Guérin).Two aspects of the LHC were presented in the display. The technical principles on which the machine is based were illustrated using a bell jar, liquid nitrogen and visually striking experiments. Meanwhile, under the heading ‘The Time Machine’, posters and mockups were used to explain the theoretical side of the LHC and its scientific aims. Benefitting from the adjacent photography exhibition, ‘CERN through the lens of Peter Ginter’, the stand attracted a steady stream of intere...

  15. ParTIES: a toolbox for Paramecium interspersed DNA elimination studies.

    Science.gov (United States)

    Denby Wilkes, Cyril; Arnaiz, Olivier; Sperling, Linda

    2016-02-15

    Developmental DNA elimination occurs in a wide variety of multicellular organisms, but ciliates are the only single-celled eukaryotes in which this phenomenon has been reported. Despite considerable interest in ciliates as models for DNA elimination, no standard methods for identification and characterization of the eliminated sequences are currently available. We present the Paramecium Toolbox for Interspersed DNA Elimination Studies (ParTIES), designed for Paramecium species, that (i) identifies eliminated sequences, (ii) measures their presence in a sequencing sample and (iii) detects rare elimination polymorphisms. ParTIES is multi-threaded Perl software available at https://github.com/oarnaiz/ParTIES. ParTIES is distributed under the GNU General Public Licence v3. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  16. Does Altered Uric Acid Metabolism Contribute to Diabetic Kidney Disease Pathophysiology?

    Science.gov (United States)

    Gul, Ambreen; Zager, Philip

    2018-03-01

    Multiple experimental and clinical studies have identified pathways by which uric acid may facilitate the development and progression of chronic kidney disease (CKD) in people with diabetes. However, it remains uncertain if the association of uric acid with CKD represents a pathogenic effect or merely reflects renal impairment. In contrast to many published reports, a recent Mendelian randomization study did not identify a causal link between uric acid and CKD in people with type 1 diabetes. Two recent multicenter randomized control trials, Preventing Early Renal Function Loss in Diabetes (PERL) and FEbuxostat versus placebo rAndomized controlled Trial regarding reduced renal function in patients with Hyperuricemia complicated by chRonic kidney disease stage 3 (FEATHER), were recently designed to assess if uric acid lowering slows progression of CKD. We review the evidence supporting a role for uric acid in the pathogenesis of CKD in people with diabetes and the putative benefits of uric acid lowering.

  17. Psicoterapeutas iniciantes: os desafios das diversidades afetivo-sexuais

    Directory of Open Access Journals (Sweden)

    Maria Alves de Toledo Bruns

    2011-04-01

    Full Text Available This article is a report of a supervision experience with cases of clients with affective-sexual claims brought to me by psychotherapists adopting the Person-centered approach developed by Carl Rogers (1902-1987 and the Gestalt Therapy, by Fritz Perls (1893-1970. Its aim is to foster a critical reflection upon a gap in new psychotherapists’ education regarding the contemporary sexual diversity in an interface with the existential phenomenological paradigm pondering that contemporary individuals have been experiencing profound transformation in their lebenswelt, lifeworld, in their affective, emotional and sexual relationships which dialectically reflect their imprisonment to the paradigm of sexual pleasure as to abominate frustrations and conflicts, crises inherent to the horizons of an individual’s development. The article establishes a critical-reflexive dialog with authors committed to researching such issues, who have been pointing out the impasse and challenges of the contemporary clinic.

  18. A TALE-inspired computational screen for proteins that contain approximate tandem repeats.

    Science.gov (United States)

    Perycz, Malgorzata; Krwawicz, Joanna; Bochtler, Matthias

    2017-01-01

    TAL (transcription activator-like) effectors (TALEs) are bacterial proteins that are secreted from bacteria to plant cells to act as transcriptional activators. TALEs and related proteins (RipTALs, BurrH, MOrTL1 and MOrTL2) contain approximate tandem repeats that differ in conserved positions that define specificity. Using PERL, we screened ~47 million protein sequences for TALE-like architecture characterized by approximate tandem repeats (between 30 and 43 amino acids in length) and sequence variability in conserved positions, without requiring sequence similarity to TALEs. Candidate proteins were scored according to their propensity for nuclear localization, secondary structure, repeat sequence complexity, as well as covariation and predicted structural proximity of variable residues. Biological context was tentatively inferred from co-occurrence of other domains and interactome predictions. Approximate repeats with TALE-like features that merit experimental characterization were found in a protein of chestnut blight fungus, a eukaryotic plant pathogen.

  19. Finding, Browsing and Getting Data Easily Using SPDF Web Services

    Science.gov (United States)

    Candey, R.; Chimiak, R.; Harris, B.; Johnson, R.; Kovalick, T.; Lal, N.; Leckner, H.; Liu, M.; McGuire, R.; Papitashvili, N.; hide

    2010-01-01

    The NASA GSFC Space Physics Data Facility (5PDF) provides heliophysics science-enabling information services for enhancing scientific research and enabling integration of these services into the Heliophysics Data Environment paradigm, via standards-based approach (SOAP) and Representational State Transfer (REST) web services in addition to web browser, FTP, and OPeNDAP interfaces. We describe these interfaces and the philosophies behind these web services, and show how to call them from various languages, such as IDL and Perl. We are working towards a "one simple line to call" philosophy extolled in the recent VxO discussions. Combining data from many instruments and missions enables broad research analysis and correlation and coordination with other experiments and missions.

  20. A Reliability Comparison of Classical and Stochastic Thickness Margin Approaches to Address Material Property Uncertainties for the Orion Heat Shield

    Science.gov (United States)

    Sepka, Steve; Vander Kam, Jeremy; McGuire, Kathy

    2018-01-01

    The Orion Thermal Protection System (TPS) margin process uses a root-sum-square approach with branches addressing trajectory, aerothermodynamics, and material response uncertainties in ablator thickness design. The material response branch applies a bond line temperature reduction between the Avcoat ablator and EA9394 adhesive by 60 C (108 F) from its peak allowed value of 260 C (500 F). This process is known as the Bond Line Temperature Material Margin (BTMM) and is intended to cover material property and performance uncertainties. The value of 60 C (108 F) is a constant, applied at any spacecraft body location and for any trajectory. By varying only material properties in a random (monte carlo) manner, the perl-based script mcCHAR is used to investigate the confidence interval provided by the BTMM. In particular, this study will look at various locations on the Orion heat shield forebody for a guided and an abort (ballistic) trajectory.

  1. Prediction of novel pre-microRNAs with high accuracy through boosting and SVM.

    Science.gov (United States)

    Zhang, Yuanwei; Yang, Yifan; Zhang, Huan; Jiang, Xiaohua; Xu, Bo; Xue, Yu; Cao, Yunxia; Zhai, Qian; Zhai, Yong; Xu, Mingqing; Cooke, Howard J; Shi, Qinghua

    2011-05-15

    High-throughput deep-sequencing technology has generated an unprecedented number of expressed short sequence reads, presenting not only an opportunity but also a challenge for prediction of novel microRNAs. To verify the existence of candidate microRNAs, we have to show that these short sequences can be processed from candidate pre-microRNAs. However, it is laborious and time consuming to verify these using existing experimental techniques. Therefore, here, we describe a new method, miRD, which is constructed using two feature selection strategies based on support vector machines (SVMs) and boosting method. It is a high-efficiency tool for novel pre-microRNA prediction with accuracy up to 94.0% among different species. miRD is implemented in PHP/PERL+MySQL+R and can be freely accessed at http://mcg.ustc.edu.cn/rpg/mird/mird.php.

  2. HippDB: a database of readily targeted helical protein-protein interactions.

    Science.gov (United States)

    Bergey, Christina M; Watkins, Andrew M; Arora, Paramjit S

    2013-11-01

    HippDB catalogs every protein-protein interaction whose structure is available in the Protein Data Bank and which exhibits one or more helices at the interface. The Web site accepts queries on variables such as helix length and sequence, and it provides computational alanine scanning and change in solvent-accessible surface area values for every interfacial residue. HippDB is intended to serve as a starting point for structure-based small molecule and peptidomimetic drug development. HippDB is freely available on the web at http://www.nyu.edu/projects/arora/hippdb. The Web site is implemented in PHP, MySQL and Apache. Source code freely available for download at http://code.google.com/p/helidb, implemented in Perl and supported on Linux. arora@nyu.edu.

  3. New Directions in the NOAO Observing Proposal System

    Science.gov (United States)

    Gasson, David; Bell, Dave

    For the past eight years NOAO has been refining its on-line observing proposal system. Virtually all related processes are now handled electronically. Members of the astronomical community can submit proposals through email, web form, or via the Gemini Phase I Tool. NOAO staff can use the system to do administrative tasks, scheduling, and compilation of various statistics. In addition, all information relevant to the TAC process is made available on-line, including the proposals themselves (in HTML, PDF and PostScript) and technical comments. Grades and TAC comments are entered and edited through web forms, and can be sorted and filtered according to specified criteria. Current developments include a move away from proprietary solutions, toward open standards such as SQL (in the form of the MySQL relational database system), Perl, PHP and XML.

  4. A new Information Architecture, Website and Services for the CMS Experiment

    Science.gov (United States)

    Taylor, Lucas; Rusack, Eleanor; Zemleris, Vidmantas

    2012-12-01

    The age and size of the CMS collaboration at the LHC means it now has many hundreds of inhomogeneous web sites and services, and hundreds of thousands of documents. We describe a major initiative to create a single coherent CMS internal and public web site. This uses the Drupal web Content Management System (now supported by CERN/IT) on top of a standard LAMP stack (Linux, Apache, MySQL, and php/perl). The new navigation, content and search services are coherently integrated with numerous existing CERN services (CDS, EDMS, Indico, phonebook, Twiki) as well as many CMS internal Web services. We describe the information architecture; the system design, implementation and monitoring; the document and content database; security aspects; and our deployment strategy, which ensured continual smooth operation of all systems at all times.

  5. The application of the SXF lattice description and the UAL software environment to the analysis of the LHC

    CERN Document Server

    Fischer, W; Ptitsyn, V I

    1999-01-01

    A software environment for accelerator modeling has been developed which includes the UAL (Unified Accelerator Library), a collection of accelerator physics libraries with a Perl interface for scripting, and the SXF (Standard eX-change Format), a format for accelerator description which extends the MAD sequence by including deviations from design values. SXF interfaces have been written for several programs, including MAD9 and MAD8 via the doom database, Cosy, TevLat and UAL itself, which includes Teapot++. After an overview of the software we describe the application of the tools to the analysis of the LHC lattice stability, in the presence of alignment and coupling errors, and to the correction of the first turn and closed orbit in the machine. (7 refs).

  6. Numerical analysis of anisotropic diffusion effect on ICF hydrodynamic instabilities

    Directory of Open Access Journals (Sweden)

    Olazabal-Loumé M.

    2013-11-01

    Full Text Available The effect of anisotropic diffusion on hydrodynamic instabilities in the context of Inertial Confinement Fusion (ICF flows is numerically assessed. This anisotropy occurs in indirect-drive when laminated ablators are used to modify the lateral transport [1,2]. In direct-drive, non-local transport mechanisms and magnetic fields may modify the lateral conduction [3]. In this work, numerical simulations obtained with the code PERLE [4], dedicated to linear stability analysis, are compared with previous theoretical results [5]. In these approaches, the diffusion anisotropy can be controlled by a characteristic coefficient which enables a comprehensive study. This work provides new results on the ablative Rayleigh-Taylor (RT, ablative Richtmyer-Meshkov (RM and Darrieus-Landau (DL instabilities.

  7. Development of Visualization Tools for ZPPR-15 Analysis

    International Nuclear Information System (INIS)

    Lee, Min Jae; Kim, Sang Ji

    2014-01-01

    ZPPR-15 cores consist of various drawer masters that have great heterogeneity. In order to build a proper homogenization strategy, the geometry of the drawer masters should be carefully analyzed with a visualization. Additionally, a visualization of drawer masters and the core configuration is necessary for minimizing human error during the input processing. For this purpose, visualization tools for a ZPPR-15 analysis has been developed based on a Perl script. In the following section, the implementation of visualization tools will be described and various visualization samples for both drawer masters and ZPPR-15 cores will be demonstrated. Visualization tools for drawer masters and a core configuration were successfully developed for a ZPPR-15 analysis. The visualization tools are expected to be useful for understanding ZPPR-15 experiments, and finding deterministic models of ZPPR-15. It turned out that generating VTK files is handy but the application of VTK files is powerful with the aid of the VISIT program

  8. Device Configuration Handler for Accelerator Control Applications at Jefferson Lab

    International Nuclear Information System (INIS)

    Bickley, Matt; Chevtsov, P.; Larrieu, T.

    2003-01-01

    The accelerator control system at Jefferson Lab uses hundreds of physical devices with such popular instrument bus interfaces as Industry Pack (IPAC), GPIB, RS-232, etc. To properly handle all these components, control computers (IOCs) must be provided with the correct information about the unique memory addresses of the used interface cards, interrupt numbers (if any), data communication channels and protocols. In these conditions, the registration of a new control device in the control system is not an easy task for software developers. Because the device configuration is distributed, it requires the detailed knowledge about not only the new device but also the configuration of all other devices on the existing system. A configuration handler implemented at Jefferson Lab centralizes the information about all control devices making their registration user-friendly and very easy to use. It consists of a device driver framework and the device registration software developed on the basis of ORACLE database and freely available scripting tools (perl, php)

  9. CoreFlow: A computational platform for integration, analysis and modeling of complex biological data

    DEFF Research Database (Denmark)

    Pasculescu, Adrian; Schoof, Erwin; Creixell, Pau

    2014-01-01

    between data generation, analysis and manuscript writing. CoreFlow is being released to the scientific community as an open-sourced software package complete with proteomics-specific examples, which include corrections for incomplete isotopic labeling of peptides (SILAC) or arginine-to-proline conversion......A major challenge in mass spectrometry and other large-scale applications is how to handle, integrate, and model the data that is produced. Given the speed at which technology advances and the need to keep pace with biological experiments, we designed a computational platform, CoreFlow, which...... provides programmers with a framework to manage data in real-time. It allows users to upload data into a relational database (MySQL), and to create custom scripts in high-level languages such as R, Python, or Perl for processing, correcting and modeling this data. CoreFlow organizes these scripts...

  10. Lightweight computational steering of very large scale molecular dynamics simulations

    International Nuclear Information System (INIS)

    Beazley, D.M.

    1996-01-01

    We present a computational steering approach for controlling, analyzing, and visualizing very large scale molecular dynamics simulations involving tens to hundreds of millions of atoms. Our approach relies on extensible scripting languages and an easy to use tool for building extensions and modules. The system is extremely easy to modify, works with existing C code, is memory efficient, and can be used from inexpensive workstations and networks. We demonstrate how we have used this system to manipulate data from production MD simulations involving as many as 104 million atoms running on the CM-5 and Cray T3D. We also show how this approach can be used to build systems that integrate common scripting languages (including Tcl/Tk, Perl, and Python), simulation code, user extensions, and commercial data analysis packages

  11. ABMapper: a suffix array-based tool for multi-location searching and splice-junction mapping.

    Science.gov (United States)

    Lou, Shao-Ke; Ni, Bing; Lo, Leung-Yau; Tsui, Stephen Kwok-Wing; Chan, Ting-Fung; Leung, Kwong-Sak

    2011-02-01

    Sequencing reads generated by RNA-sequencing (RNA-seq) must first be mapped back to the genome through alignment before they can be further analyzed. Current fast and memory-saving short-read mappers could give us a quick view of the transcriptome. However, they are neither designed for reads that span across splice junctions nor for repetitive reads, which can be mapped to multiple locations in the genome (multi-reads). Here, we describe a new software package: ABMapper, which is specifically designed for exploring all putative locations of reads that are mapped to splice junctions or repetitive in nature. The software is freely available at: http://abmapper.sourceforge.net/. The software is written in C++ and PERL. It runs on all major platforms and operating systems including Windows, Mac OS X and LINUX.

  12. CLIP Tool Kit (CTK): a flexible and robust pipeline to analyze CLIP sequencing data.

    Science.gov (United States)

    Shah, Ankeeta; Qian, Yingzhi; Weyn-Vanhentenryck, Sebastien M; Zhang, Chaolin

    2017-02-15

    UV cross-linking and immunoprecipitation (CLIP), followed by high-throughput sequencing, is a powerful biochemical assay that maps in vivo protein-RNA interactions on a genome-wide scale. The CLIP Tool Kit (CTK) aims at providing a set of tools for flexible, streamlined and comprehensive CLIP data analysis. This software package extends the scope of our original CIMS package. The software is implemented in Perl. The source code and detailed documentation are available at http://zhanglab.c2b2.columbia.edu/index.php/CTK . cz2294@columbia.edu. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

  13. ON-FARM MANAGEMENT SYSTEMS IN ANIMAL PRODUCTION

    Directory of Open Access Journals (Sweden)

    Aleksandra Jug

    2000-06-01

    Full Text Available The on-farm management systems under development in order to insure data collection, regular data processing needed on a farm as well as automatic data exchange between farm and computing centre. The core of information system presents relational database (RDBMS accompanied with tools developed in APIIS. A system analysis method has been done on two pig industrial units, on national selection program for swine in Slovenia, and compared with examples from other countries and species. Public domain software like PostgreSQL, Perl and Linux have been chosen for use on farms and can be replaced with commercial software like Oracle for more demanding central systems. The system contains at this stage applications for entering, managing, and viewing the data as well as transferring the information between local and central databases.

  14. Entre l'authenticité et l’illusion : Macao, ville du patrimoine mondial et du jeu

    OpenAIRE

    Drouin, Martin

    2012-01-01

    Bordant la mer de Chine de chaque côté du delta de la rivière des Perles, Hong Kong et Macao ont fait rêver plus d’un voyageur. En dépit des similitudes évoquées, les deux destinations ne projettent pas du tout la même image. Leur contenu semble presque même s’opposer. Plus particulièrement, tel est le thème de la présente chronique, la place occupée par le patrimoine culturel dans l’expérience touristique diffère considérablement, malgré les transformations notables observées au cours des de...

  15. The materno-fetal interface in llama (Lama guanicoe glama A interface materno-fetal em lhamas (Lama guanicoe glama

    Directory of Open Access Journals (Sweden)

    David M. Iturrizaga

    2007-06-01

    Full Text Available Samples from 9 llamas (28 through 36 weeks of gestation were collected and fixed in 4% buffered paraformaldehyde (light microscopy and in 2.5% buffered glutaraldehyde (transmission and scanning electron microscopy. The material was processed in paraplast and slides (5mm were stained with HE, PAS, Masson-Trichrome, acid phosphatase and Perl's. The uteroferrin was immunolocalized. The results show that llama placenta is chorioallantoic, diffuse, folded and epitheliochorial, and the fetus is covered with an epidermal membrane. The trophoblast cells have variable morphology: cubic, rounded and triangular cells, with cytoplasm containing PAS-positive granules. Binucleated cells with large cytoplasm and rounded nuclei, as well as giant trophoblastic cells with multiple nuclei were also observed. Numerous blood vessels were observed beneath the cells of the uterine epithelium and around the chorionic subdivided branches. Glandular activity was shown by PAS, Perl's, and acid phosphatase positive reactions in the cytoplasm and glandular lumen, and by immunolocalization of the uteroferrin in the glandular epithelium. The uterine glands open in spaces formed by the areoles, which are filled by PAS-positive material. The llama fetus was covered by the epidermal membrane, composed of stratified epithelium, with up to seven layers of mono-, bi- or trinucleated cells. The high level of maternal and fetal vascularization surfaces indicates an intense exchange of substances across both surfaces. The metabolic activity shown in the uterine glands suggests an adaptation of the gestation to the high altitudes of the natural habitat of this species.Fragmentos da placenta de 9 animais (28-36 semanas de gestação, provenientes do Instituto Veterinario de Investigaciones Tropicales y de Altura (IVITA, Cusco-Peru, e da Universidad del Altiplano (UNA, Puno-Peru, foram colhidos e fixados em paraformoldeído 4% em PBS para microscopia de luz e em glutaraldeido em 2,5% PBS

  16. Trends at a Glance: A Management Dashboard of Library Statistics

    Directory of Open Access Journals (Sweden)

    Emily G Morton-Owens

    2012-09-01

    Full Text Available Systems librarians at an academic medical library created a management data dashboard. Charts were designed using best practices for data visualization and dashboard layout, and include metrics on gatecount, website visits, IM reference chats, circulation, and ILL volume and turnaround time. Several charts draw on EZproxy log data that has been analyzed and linked to other databases to reveal use by different academic departments and user roles (such as faculty or student. Most charts are bar charts and include a linear regression trendline. The implementation uses Perl scripts to retrieve data from eight different sources and add it to a MySQL data warehouse, from which PHP/Javascript webpages use Google Chart Tools to create the dashboard charts.

  17. Applications of sealed sources in chemical engineering. III

    International Nuclear Information System (INIS)

    Pokorny, J.; Zaloudik, P.; Thyn, J.

    1980-01-01

    Agitated ball mills (ABM, sand or Perl mills, Ruehrwerksmuehle) have found wide applications in wet tumbling of solids. The applications of ABM in dry tumbling started recently and stimulated studies into some specific characteristics of ABM. Our work on dry grinding in 5, 20 and 100 litres ABM pointed to the important role played by shaft power in scaling up. An important parameter for the assessment of mill shaft power requirements is the bulk density of the milling charge and its local values throughout the mill. Focusing attention on density we experimented on a 8-litre glass model of ABM filled with 4 millimetres polystyrene balls used as a milling charge. The bulk density of the milling charge was measured radiometrically under dry grinding conditions and the results were used in equations for the mill power consumption. (author)

  18. RNA-Seq-Based Transcript Structure Analysis with TrBorderExt.

    Science.gov (United States)

    Wang, Yejun; Sun, Ming-An; White, Aaron P

    2018-01-01

    RNA-Seq has become a routine strategy for genome-wide gene expression comparisons in bacteria. Despite lower resolution in transcript border parsing compared with dRNA-Seq, TSS-EMOTE, Cappable-seq, Term-seq, and others, directional RNA-Seq still illustrates its advantages: low cost, quantification and transcript border analysis with a medium resolution (±10-20 nt). To facilitate mining of directional RNA-Seq datasets especially with respect to transcript structure analysis, we developed a tool, TrBorderExt, which can parse transcript start sites and termination sites accurately in bacteria. A detailed protocol is described in this chapter for how to use the software package step by step to identify bacterial transcript borders from raw RNA-Seq data. The package was developed with Perl and R programming languages, and is accessible freely through the website: http://www.szu-bioinf.org/TrBorderExt .

  19. Everything you wanted to know about data analysis and fitting but were afraid to ask

    CERN Document Server

    Young, Peter

    2015-01-01

    These notes describe how to average and fit numerical data that have been obtained either by simulation or measurement. Following an introduction on how to estimate various average values, they discuss how to determine error bars on those estimates, and how to proceed for combinations of measured values. Techniques for fitting data to a given set of models will be described in the second part of these notes. This primer equips readers to properly derive the results covered, presenting the content in a style suitable for a physics audience. It also includes scripts in python, perl and gnuplot for performing a number of tasks in data analysis and fitting, thereby providing readers with a useful reference guide.

  20. How to make x-ray simulation software working on WWW: a simple recipe based on seven years of experience

    International Nuclear Information System (INIS)

    Stepanov, S.

    2004-01-01

    Attaching WWW interfaces to scientific software opens new opportunities to researchers by making their results available to wide scientific community in a way complimentary to publication. We have shown that this task may be much easier than many used to think: the amount of additional code is small, the Common Gateway Interface (CGI) can be written in any language, not necessarily PERL, and the software can be interfaced on any operating system it was originally written and does not have to be ported to UNIX. This paper provides some useful recipes resulted from seven years of author's experience in developing and maintaining highly successful X-ray Web server project. All these solutions are based on free public domain software (Apache, GnuPlot, and InfoZip) and applicable for multiple computer platforms. Some practical examples are provided.

  1. A New Information Architecture, Web Site and Services for the CMS Experiment

    CERN Multimedia

    CERN. Geneva

    2012-01-01

    The age and size of the CMS collaboration at the LHC means it now has many hundreds of inhomogeneous web sites and services and more than 100,000 documents. We describe a major initiative to create a single coherent CMS internal and public web site. This uses the Drupal web Content Management System (now supported by CERN/IT) on top of a standard LAMP stack (Linux, Apache, MySQL, and php/perl). The new navigation, content and search services are coherently integrated with numerous existing CERN services (CDS, EDMS, Indico, phonebook, Twiki) as well as many CMS internal Web services. We describe the information architecture; the system design, implementation and monitoring; the document and content database; security aspects; and our deployment strategy which ensured continual smooth operation of all systems at all times.

  2. biojs-io-biom, a BioJS component for handling data in Biological Observation Matrix (BIOM format [version 2; referees: 1 approved, 2 approved with reservations

    Directory of Open Access Journals (Sweden)

    Markus J. Ankenbrand

    2017-01-01

    Full Text Available The Biological Observation Matrix (BIOM format is widely used to store data from high-throughput studies. It aims at increasing interoperability of bioinformatic tools that process this data. However, due to multiple versions and implementation details, working with this format can be tricky. Currently, libraries in Python, R and Perl are available, whilst such for JavaScript are lacking. Here, we present a BioJS component for parsing BIOM data in all format versions. It supports import, modification, and export via a unified interface. This module aims to facilitate the development of web applications that use BIOM data. Finally, we demonstrate its usefulness by two applications that already use this component. Availability: https://github.com/molbiodiv/biojs-io-biom, https://dx.doi.org/10.5281/zenodo.218277

  3. Gromita: a fully integrated graphical user interface to gromacs 4.

    Science.gov (United States)

    Sellis, Diamantis; Vlachakis, Dimitrios; Vlassi, Metaxia

    2009-09-07

    Gromita is a fully integrated and efficient graphical user interface (GUI) to the recently updated molecular dynamics suite Gromacs, version 4. Gromita is a cross-platform, perl/tcl-tk based, interactive front end designed to break the command line barrier and introduce a new user-friendly environment to run molecular dynamics simulations through Gromacs. Our GUI features a novel workflow interface that guides the user through each logical step of the molecular dynamics setup process, making it accessible to both advanced and novice users. This tool provides a seamless interface to the Gromacs package, while providing enhanced functionality by speeding up and simplifying the task of setting up molecular dynamics simulations of biological systems. Gromita can be freely downloaded from http://bio.demokritos.gr/gromita/.

  4. Chado controller: advanced annotation management with a community annotation system.

    Science.gov (United States)

    Guignon, Valentin; Droc, Gaëtan; Alaux, Michael; Baurens, Franc-Christophe; Garsmeur, Olivier; Poiron, Claire; Carver, Tim; Rouard, Mathieu; Bocs, Stéphanie

    2012-04-01

    We developed a controller that is compliant with the Chado database schema, GBrowse and genome annotation-editing tools such as Artemis and Apollo. It enables the management of public and private data, monitors manual annotation (with controlled vocabularies, structural and functional annotation controls) and stores versions of annotation for all modified features. The Chado controller uses PostgreSQL and Perl. The Chado Controller package is available for download at http://www.gnpannot.org/content/chado-controller and runs on any Unix-like operating system, and documentation is available at http://www.gnpannot.org/content/chado-controller-doc The system can be tested using the GNPAnnot Sandbox at http://www.gnpannot.org/content/gnpannot-sandbox-form valentin.guignon@cirad.fr; stephanie.sidibe-bocs@cirad.fr Supplementary data are available at Bioinformatics online.

  5. Stereological quantification of immune-competent cells in baseline biopsy specimens from achilles tendons

    DEFF Research Database (Denmark)

    Kragsnaes, Maja Skov; Fredberg, Ulrich; Stribolt, Katrine

    2014-01-01

    BACKGROUND: Limited data exist on the presence and function of immune-competent cells in chronic tendinopathic tendons and their potential role in inflammation and tissue healing as well as in predicting long-term outcome. PURPOSE: To quantify subtypes of immune-competent cells in biopsy specimens...... immunohistochemically by quantifying the presence of macrophages (CD68-PGM1(+), CD68-KP1(+)), hemosiderophages (Perls blue), T lymphocytes (CD2(+), CD3(+), CD4(+), CD7(+), CD8(+)), B lymphocytes (CD20(+)), natural killer cells (CD56(+)), mast cells (NaSDCl(+)), Schwann cells (S100(+)), and endothelial cells (CD34......(+)) using a stereological technique. A follow-up examination was conducted more than 4 years (range, 4-9 years) after the biopsy procedure to evaluate the long-term presence of Achilles tendon symptoms. RESULTS: Macrophages, T lymphocytes, mast cells, and natural killer cells were observed in the majority...

  6. New strategic directions for Caribbean CSM project.

    Science.gov (United States)

    1986-01-01

    Recent changes in the strategy of the Caribbean Contraceptive Social Marketing Project emphasize the condom, under the brand name, Panther. Since 1984, CCSMP began marketing their Perle rand of oral contraceptive, since dropped, in Barbados, St. Vincent and St. Lucia. Now wider commercial connections are envisioned, with support by CCSMP to promote generic brands. The Panther condom campaign will include an array of mass media, point-of-purchase and sporting event advertising. Pharmacies report that Panther is selling as well as the leading commercial brand. CCSMP is looking to introduce an ultra-thin condom and a vaginal foaming tablet. Market research, involving physicians and users as well as retail audits, indicates that although population in numbers alone is not a serious problem in the Caribbean, early pregnancy is a concern in the area.

  7. A new information architecture, website and services for the CMS experiment

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, Lucas [Fermilab; Rusack, Eleanor [Fermilab; Zemleris, Vidmantas [Vilnius U.

    2012-01-01

    The age and size of the CMS collaboration at the LHC means it now has many hundreds of inhomogeneous web sites and services, and hundreds of thousands of documents. We describe a major initiative to create a single coherent CMS internal and public web site. This uses the Drupal web Content Management System (now supported by CERN/IT) on top of a standard LAMP stack (Linux, Apache, MySQL, and php/perl). The new navigation, content and search services are coherently integrated with numerous existing CERN services (CDS, EDMS, Indico, phonebook, Twiki) as well as many CMS internal Web services. We describe the information architecture, the system design, implementation and monitoring, the document and content database, security aspects, and our deployment strategy, which ensured continual smooth operation of all systems at all times.

  8. Gonfaron

    OpenAIRE

    Borréani, Marc

    2013-01-01

    Identifiant de l'opération archéologique : 8328 Date de l'opération : 2007 (PR) Inventeur(s) : Borréani Marc (COL) La prospection de la commune de Gonfaron a essentiellement permis de compléter les données des sites déjà inventoriés, le nombre de nouveaux sites trouvés étant faible. À l’issue de ce travail, l’inventaire comporte trente fiches. Néolithique Cette période est documentée par trois grottes sépulcrales situées sur la colline de la Roquette : la grotte des Perles, la grotte de la Ro...

  9. Plann: A command-line application for annotating plastome sequences.

    Science.gov (United States)

    Huang, Daisie I; Cronk, Quentin C B

    2015-08-01

    Plann automates the process of annotating a plastome sequence in GenBank format for either downstream processing or for GenBank submission by annotating a new plastome based on a similar, well-annotated plastome. Plann is a Perl script to be executed on the command line. Plann compares a new plastome sequence to the features annotated in a reference plastome and then shifts the intervals of any matching features to the locations in the new plastome. Plann's output can be used in the National Center for Biotechnology Information's tbl2asn to create a Sequin file for GenBank submission. Unlike Web-based annotation packages, Plann is a locally executable script that will accurately annotate a plastome sequence to a locally specified reference plastome. Because it executes from the command line, it is ready to use in other software pipelines and can be easily rerun as a draft plastome is improved.

  10. A new Information Architecture, Website and Services for the CMS Experiment

    International Nuclear Information System (INIS)

    Taylor, Lucas; Rusack, Eleanor; Zemleris, Vidmantas

    2012-01-01

    The age and size of the CMS collaboration at the LHC means it now has many hundreds of inhomogeneous web sites and services, and hundreds of thousands of documents. We describe a major initiative to create a single coherent CMS internal and public web site. This uses the Drupal web Content Management System (now supported by CERN/IT) on top of a standard LAMP stack (Linux, Apache, MySQL, and php/perl). The new navigation, content and search services are coherently integrated with numerous existing CERN services (CDS, EDMS, Indico, phonebook, Twiki) as well as many CMS internal Web services. We describe the information architecture; the system design, implementation and monitoring; the document and content database; security aspects; and our deployment strategy, which ensured continual smooth operation of all systems at all times.

  11. Wildfire: distributed, Grid-enabled workflow construction and execution

    Directory of Open Access Journals (Sweden)

    Issac Praveen

    2005-03-01

    Full Text Available Abstract Background We observe two trends in bioinformatics: (i analyses are increasing in complexity, often requiring several applications to be run as a workflow; and (ii multiple CPU clusters and Grids are available to more scientists. The traditional solution to the problem of running workflows across multiple CPUs required programming, often in a scripting language such as perl. Programming places such solutions beyond the reach of many bioinformatics consumers. Results We present Wildfire, a graphical user interface for constructing and running workflows. Wildfire borrows user interface features from Jemboss and adds a drag-and-drop interface allowing the user to compose EMBOSS (and other programs into workflows. For execution, Wildfire uses GEL, the underlying workflow execution engine, which can exploit available parallelism on multiple CPU machines including Beowulf-class clusters and Grids. Conclusion Wildfire simplifies the tasks of constructing and executing bioinformatics workflows.

  12. BioSmalltalk: a pure object system and library for bioinformatics.

    Science.gov (United States)

    Morales, Hernán F; Giovambattista, Guillermo

    2013-09-15

    We have developed BioSmalltalk, a new environment system for pure object-oriented bioinformatics programming. Adaptive end-user programming systems tend to become more important for discovering biological knowledge, as is demonstrated by the emergence of open-source programming toolkits for bioinformatics in the past years. Our software is intended to bridge the gap between bioscientists and rapid software prototyping while preserving the possibility of scaling to whole-system biology applications. BioSmalltalk performs better in terms of execution time and memory usage than Biopython and BioPerl for some classical situations. BioSmalltalk is cross-platform and freely available (MIT license) through the Google Project Hosting at http://code.google.com/p/biosmalltalk hernan.morales@gmail.com Supplementary data are available at Bioinformatics online.

  13. Nobel drawings

    CERN Multimedia

    Michel Blanc

    2009-01-01

    1. The Universe in One Drawing (G. Smoot Physics 2006) 2. Superfluid Properties (R. Richardson Physics 1996) 3. The Asymptotic Freedom of the Quark (David Gross, Physics 2004) 4. Understanding Superfluidity (Anthony Legget, Physics 2003) 5. Taming Infinities (G. 't Hooft, Physics 1999) 6. Homo Diagrammaticus (M. Veltman, Physics 1999) 7. A Tale Of Two Liquids (D. Osheroff, Physics 1996) 8. Wire Proliferation (G. Charpak, Physics 1992) 9. High Temperature Superconductivity (G. Bednorz, Physics 1987) 10. Atomic Cuisine (courtesy of C. Rubbia, Physics 1984) 11. Colliding Charm (S. Ting, Physics 1976) 12. The Bubble Chamber ( D. Glaser, Physics 1960) 13. The Narrow Resonance of the J-Psi (B. Richter, Physics 1976) 14. Stochastic Cooling (S. Van der Meer, Physics 1984) 15. The Good Anomaly (J Steinberger, Physics 1988) 16. Quark Somewhere on the White Paper (R. Taylor, Physics 1990) 17. The Tau of Particle Physics (M. Perl, 1995) 18. NMR Spectroscopy (K. Wuethrich, Chemistry 2002) 19. Coherent States (R....

  14. Rugby Club CERN Meyrin St-Genis (RC CMSG) – Women’s team

    CERN Multimedia

    Rugby Club

    2015-01-01

    The 2015-2016 rugby season start is just around the corner for the “RUGBY CERN” ladies team. In order to be ready for the first official clash to be held mid-September, the Wildcats have engaged in fitness training sessions throughout the month of August. Every Thursday, the players meet at 19h30 by the Perl du Lac in Geneva for a bootcamp session while on Tuesdays, the team gathers for an aerobic training session, in Meyrin. Feel free to join the ladies for any of the sessions. Not only will you have a great workout but also enjoy the well-known rugby fun environment. All levels are welcome! For more information, do not hesitate to contact us: wildcats@cern-rugby.ch www.cern-rugy.ch // facebook : Wildcats Women’s Rugby

  15. A primary study on the phagocytic activity of Kupffer cells with superparamagnetic iron oxide particles enhanced MR imaging in a rat nonalcoholic steatohepatitis model

    International Nuclear Information System (INIS)

    Jiao Zhiyun; Li Cheng; Ma Zhanlong; Chen Wenjuan

    2010-01-01

    Objective: To investigate the feasibility of using superparamgnetic iron oxide (SPIO) as MRI contrast agent to assess rat nonalcoholic steatohepatitis Kupffer cells (KC) function. Methods: Twenty male SD rats were randomly divided into A and B groups, group A (n=10) was the experimental group fed high fat diet, group B (n=10) was the control group fed normal diet. After 8 weeks, plain MR and SPIO enhanced MR were performed in all the rats. Blood lipids were measured, and HE and Perl's blue staining in all livers specimen was done. The related results of the staining were analyzed with t test. Results: Group A TC and TG levels [(6.58 ± 1.25) and (1.53 ± 0.23) mmol/L respectively] were significantly higher than group B[(1.64 ± 0.22) and (0.55 ± 0.14) mmol/L respectively] (t=11.716 and 11.588, P 1 WI, ad statistically significant differences (t=-18.451 and -16.240, P 2 WI, T 2 WI and T 1 WI (t=10.745, 19.800, 39.168 and 92.785, P<0.01). Typical histological hepatic lesions of NASH were observed in group A, Perl's staining-positive particles in group A (2.33 ± 0.50) were fewer than in group B (4) (t=-10.000, P<0.01). Conclusion: The high-fat diet induced model of SD rats was close to the human NASH and was easy to establish. Clinical application of SPIO enhanced MR successfullly assessed the phagocytic activity of KC in the study, and it suggested that the pathogenesis of NASH was related to the decreased phagocytic activity of KC. (authors)

  16. A Web-based database for pathology faculty effort reporting.

    Science.gov (United States)

    Dee, Fred R; Haugen, Thomas H; Wynn, Philip A; Leaven, Timothy C; Kemp, John D; Cohen, Michael B

    2008-04-01

    To ensure appropriate mission-based budgeting and equitable distribution of funds for faculty salaries, our compensation committee developed a pathology-specific effort reporting database. Principles included the following: (1) measurement should be done by web-based databases; (2) most entry should be done by departmental administration or be relational to other databases; (3) data entry categories should be aligned with funding streams; and (4) units of effort should be equal across categories of effort (service, teaching, research). MySQL was used for all data transactions (http://dev.mysql.com/downloads), and scripts were constructed using PERL (http://www.perl.org). Data are accessed with forms that correspond to fields in the database. The committee's work resulted in a novel database using pathology value units (PVUs) as a standard quantitative measure of effort for activities in an academic pathology department. The most common calculation was to estimate the number of hours required for a specific task, divide by 2080 hours (a Medicare year) and then multiply by 100. Other methods included assigning a baseline PVU for program, laboratory, or course directorship with an increment for each student or staff in that unit. With these methods, a faculty member should acquire approximately 100 PVUs. Some outcomes include (1) plotting PVUs versus salary to identify outliers for salary correction, (2) quantifying effort in activities outside the department, (3) documenting salary expenditure for unfunded research, (4) evaluating salary equity by plotting PVUs versus salary by sex, and (5) aggregating data by category of effort for mission-based budgeting and long-term planning.

  17. AliEn - GRID application for ALICE Collaboration

    International Nuclear Information System (INIS)

    Zgura, Ion-Sorin

    2003-01-01

    AliEn (ALICE Environment) is a GRID framework built on top of the latest Internet standards for information exchange and authentication (SOAP, PKI) and common Open Source components. AliEn provides a virtual file catalogue that allows transparent access to distributed data-sets and a number of collaborating Web services which implement the authentication, job execution, file transport, performance monitor and event logging.The ALICE experiment has developed AliEn as an implementation of distributed computing infrastructure needed to simulate, reconstruct and analyze data from the experiment. The sites that belong to the ALICE Virtual Organisation can be seen and used as a single entity - any available node executes jobs and access to logical and datasets is transparent to the user. In developing AliEn common standards and solutions in the form of Open Source components were used. Only 1% (25k physical lines of code in Perl) is native AliEn code while 99% of the code has been imported in form of Open Sources packages and Perl modules. Currently ALICE is using the system for distributed production of Monte Carlo data at over 30 sites on four continents. During the last twelve months more than 30,000 jobs have been successfully run under AliEn control worldwide, totalling 25 CPU years and producing 20 TB of data. The user interface is compatible to EU DataGrid at the level of authentication and job description language. In perspective AliEn will be interfaced to the mainstream Grid infrastructure in HEP and it will remain to serve as interface between ALICE Offline framework and external Grid infrastructure. (authors)

  18. Assessment of Fuel Analysis Methodology and Fission Product Release for 37-Element Fuel by Using the Latest IST Codes during Stagnation Feeder Break in CANDU

    International Nuclear Information System (INIS)

    Park, Joo Hwan; Jung, Jong Yeob

    2009-09-01

    Feeder break accident is regarded as one of the design basis accident in CANDU reactor which results in a fuel failure. For a particular range of inlet feeder break sizes, the flow in the channel is reduced sufficiently that the fuel and fuel channel integrity can be significantly affected to have damage in the affected channel, while the remainder of the core remains adequately cooled. The flow in the downstream channel can be more or less stagnated due to a balance between pressure at the break on the upstream side and the reverse driving pressure between the break and the downstream end. In the extreme, this can lead to rapid fuel heatup and fuel damage and failure of the fuel channel similar to that associated with a severe channel flow blockage. Such an inlet feeder break scenario is called a stagnation break. In this report, the fuel analysis methodology and the assessment results of fission product inventory and release during the stagnation feeder break are described for conservatively assumed limiting channel. The accident was assumed to be occurred in the refurbished Wolsong unit 1 and the latest safety codes were used in the analysis. Fission product inventories during the steady state were calculated by using ELESTRES-IST 1.2 code. The whole analysis process was carried out by a script file which was programmed by Perl language. The perl script file was programmed to make all ELESTRES input files for each bundle and each ring based on the given power-burnup history and thermal-hydraulic conditions of the limiting channel and to perform the fuel analysis automatically. The fission product release during the transient period of stagnation feeder break was evaluated by applying Gehl model. The amounts of each isotope's release are conservatively evaluated for additional 2 seconds after channel failure. The calculated fission product releases are provided to the following dose assessment as a source term

  19. Implementation of a Shared Resource Financial Management System

    Science.gov (United States)

    Caldwell, T.; Gerlach, R.; Israel, M.; Bobin, S.

    2010-01-01

    CF-6 Norris Cotton Cancer Center (NCCC), an NCI-designated Comprehensive Cancer Center at Dartmouth Medical School, administers 12 Life Sciences Shared Resources. These resources are diverse and offer multiple products and services. Previous methods for tracking resource use, billing, and financial management were time consuming, error prone and lacked appropriate financial management tools. To address these problems, we developed and implemented a web-based application with a built-in authorization system that uses Perl, ModPerl, Apache2, and Oracle as the software infrastructure. The application uses a role-based system to differentiate administrative users with those requesting services and includes many features requested by users and administrators. To begin development, we chose a resource that had an uncomplicated service, a large number of users, and required the use of all of the applications features. The Molecular Biology Core Facility at NCCC fit these requirements and was used as a model for developing and testing the application. After model development, institution wide deployment followed a three-stage process. The first stage was to interview the resource manager and staff to understand day-to-day operations. At the second stage, we generated and tested customized forms defining resource services. During the third stage, we added new resource users and administrators to the system before final deployment. Twelve months after deployment, resource administrators reported that the new system performed well for internal and external billing and tracking resource utilization. Users preferred the application's web-based system for distribution of DNA sequencing and other data. The sample tracking features have enhanced day-to-day resource operations, and an on-line scheduling module for shared instruments has proven a much-needed utility. Principal investigators now are able to restrict user spending to specific accounts and have final approval of the

  20. Informatics technology mimics ecology: dense, mutualistic collaboration networks are associated with higher publication rates.

    Directory of Open Access Journals (Sweden)

    Marco D Sorani

    Full Text Available Information technology (IT adoption enables biomedical research. Publications are an accepted measure of research output, and network models can describe the collaborative nature of publication. In particular, ecological networks can serve as analogies for publication and technology adoption. We constructed network models of adoption of bioinformatics programming languages and health IT (HIT from the literature.We selected seven programming languages and four types of HIT. We performed PubMed searches to identify publications since 2001. We calculated summary statistics and analyzed spatiotemporal relationships. Then, we assessed ecological models of specialization, cooperativity, competition, evolution, biodiversity, and stability associated with publications.Adoption of HIT has been variable, while scripting languages have experienced rapid adoption. Hospital systems had the largest HIT research corpus, while Perl had the largest language corpus. Scripting languages represented the largest connected network components. The relationship between edges and nodes was linear, though Bioconductor had more edges than expected and Perl had fewer. Spatiotemporal relationships were weak. Most languages shared a bioinformatics specialization and appeared mutualistic or competitive. HIT specializations varied. Specialization was highest for Bioconductor and radiology systems. Specialization and cooperativity were positively correlated among languages but negatively correlated among HIT. Rates of language evolution were similar. Biodiversity among languages grew in the first half of the decade and stabilized, while diversity among HIT was variable but flat. Compared with publications in 2001, correlation with publications one year later was positive while correlation after ten years was weak and negative.Adoption of new technologies can be unpredictable. Spatiotemporal relationships facilitate adoption but are not sufficient. As with ecosystems, dense

  1. Informatics technology mimics ecology: dense, mutualistic collaboration networks are associated with higher publication rates.

    Science.gov (United States)

    Sorani, Marco D

    2012-01-01

    Information technology (IT) adoption enables biomedical research. Publications are an accepted measure of research output, and network models can describe the collaborative nature of publication. In particular, ecological networks can serve as analogies for publication and technology adoption. We constructed network models of adoption of bioinformatics programming languages and health IT (HIT) from the literature.We selected seven programming languages and four types of HIT. We performed PubMed searches to identify publications since 2001. We calculated summary statistics and analyzed spatiotemporal relationships. Then, we assessed ecological models of specialization, cooperativity, competition, evolution, biodiversity, and stability associated with publications.Adoption of HIT has been variable, while scripting languages have experienced rapid adoption. Hospital systems had the largest HIT research corpus, while Perl had the largest language corpus. Scripting languages represented the largest connected network components. The relationship between edges and nodes was linear, though Bioconductor had more edges than expected and Perl had fewer. Spatiotemporal relationships were weak. Most languages shared a bioinformatics specialization and appeared mutualistic or competitive. HIT specializations varied. Specialization was highest for Bioconductor and radiology systems. Specialization and cooperativity were positively correlated among languages but negatively correlated among HIT. Rates of language evolution were similar. Biodiversity among languages grew in the first half of the decade and stabilized, while diversity among HIT was variable but flat. Compared with publications in 2001, correlation with publications one year later was positive while correlation after ten years was weak and negative.Adoption of new technologies can be unpredictable. Spatiotemporal relationships facilitate adoption but are not sufficient. As with ecosystems, dense, mutualistic

  2. Development and Implementation of Dynamic Scripts to Support Local Model Verification at National Weather Service Weather Forecast Offices

    Science.gov (United States)

    Zavodsky, Bradley; Case, Jonathan L.; Gotway, John H.; White, Kristopher; Medlin, Jeffrey; Wood, Lance; Radell, Dave

    2014-01-01

    Local modeling with a customized configuration is conducted at National Weather Service (NWS) Weather Forecast Offices (WFOs) to produce high-resolution numerical forecasts that can better simulate local weather phenomena and complement larger scale global and regional models. The advent of the Environmental Modeling System (EMS), which provides a pre-compiled version of the Weather Research and Forecasting (WRF) model and wrapper Perl scripts, has enabled forecasters to easily configure and execute the WRF model on local workstations. NWS WFOs often use EMS output to help in forecasting highly localized, mesoscale features such as convective initiation, the timing and inland extent of lake effect snow bands, lake and sea breezes, and topographically-modified winds. However, quantitatively evaluating model performance to determine errors and biases still proves to be one of the challenges in running a local model. Developed at the National Center for Atmospheric Research (NCAR), the Model Evaluation Tools (MET) verification software makes performing these types of quantitative analyses easier, but operational forecasters do not generally have time to familiarize themselves with navigating the sometimes complex configurations associated with the MET tools. To assist forecasters in running a subset of MET programs and capabilities, the Short-term Prediction Research and Transition (SPoRT) Center has developed and transitioned a set of dynamic, easily configurable Perl scripts to collaborating NWS WFOs. The objective of these scripts is to provide SPoRT collaborating partners in the NWS with the ability to evaluate the skill of their local EMS model runs in near real time with little prior knowledge of the MET package. The ultimate goal is to make these verification scripts available to the broader NWS community in a future version of the EMS software. This paper provides an overview of the SPoRT MET scripts, instructions for how the scripts are run, and example use

  3. Nuclear reactor multi-physics simulations with coupled MCNP5 and STAR-CCM+

    International Nuclear Information System (INIS)

    Cardoni, Jeffrey Neil; Rizwan-uddin

    2011-01-01

    The MCNP5 Monte Carlo particle transport code has been coupled to the computational fluid dynamics code, STAR-CCM+, to provide a high fidelity multi-physics simulation tool for pressurized water nuclear reactors. The codes are executed separately and coupled externally through a Perl script. The Perl script automates the exchange of temperature, density, and volumetric heating information between the codes using ASCII text data files. Fortran90 and Java utility programs assist job automation with data post-processing and file management. The MCNP5 utility code, MAKXSF, pre-generates temperature dependent cross section libraries for the thermal feedback calculations. The MCNP5–STAR-CCM+ coupled simulation tool, dubbed MULTINUKE, was applied to a steady state, PWR cell model to demonstrate its usage and capabilities. The demonstration calculation showed reasonable results that agree with PWR values typically reported in literature. Temperature and fission reaction rate distributions were realistic and intuitive. Reactivity coefficients were also deemed reasonable in comparison to historically reported data. The demonstration problem consisted of 9,984 CFD cells and 7,489 neutronic cells. MCNP5 tallied fission energy deposition over 3,328 UO_2 cells. The coupled solution converged within eight hours and in three MULTINUKE iterations. The simulation was carried out on a 64 bit, quad core, Intel 2.8 GHz microprocessor with 1 GB RAM. The simulations on a quad core machine indicated that a massively parallelized implementation of MULTINUKE can be used to assess larger multi-million cell models. (author)

  4. HIV-infected individuals who delay, decline, or discontinue antiretroviral therapy: Comparing clinic- and peer-recruited cohorts

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    Marya eGwadz

    2014-07-01

    Full Text Available A substantial proportion of persons living with HIV/AIDS (PLHA delay, decline, or discontinue antiretroviral therapy (ART when it is medically indicated (40-45%, largely African Americans and Latinos/Hispanics. This study explores the feasibility of locating PLHA who are not on ART (PLHA-NOA through clinics and peer referral; compares the two cohorts on multi-level barriers to ART; and examines readiness to initiate/reinitiate ART, a predictor of treatment outcomes. We recruited adult HIV-infected African American and Latino/Hispanic PLHA-NOA through HIV hospital clinics and peer referral in 2012-13. Participants engaged in structured one-hour assessments with reliable/valid measures on barriers to ART. We found recruitment through peers (63.2%, 60/95 was more feasible than in clinics (36.8%, 35/90. Participants were 48.0 years old and had lived with HIV for 14.7 years on average, and 56.8% had taken ART previously. Most (61.1% were male and African American (76.8%, and 23.2% were Latino/Hispanic. Peer-recruited participants were older, had lived with HIV longer, were less engaged in HIV care, and were more likely to have taken ART previously. The cohorts differed in reasons for discontinuing ART. Levels of ART knowledge were comparable between cohorts (68.5% correct, and there were no differences in attitudes toward ART (e.g., mistrust, which were in the neutral range. In bivariate linear regression, readiness for ART was negatively associated with physician mistrust (B=-10.4, and positively associated with self-efficacy (B=5.5, positive outcome expectancies (B=6.3, beliefs about personal necessity of ART (B=17.5, and positive internal norms (B=7.9. The present study demonstrates the feasibility of engaging this vulnerable population through peer referral. Peer-recruited PLHA evidence particularly high rates of risk factors compared those in clinics. Interventions to support ART initiation and continuation are sorely needed for both subgroups.

  5. Evaluación de insecticidas curasemillas para el control de Sternechus subsignatus Boheman (Coleoptera: Curculionidae en las primeras etapas de desarrollo del cultivo de soja Evaluation of seed treatment insecticides for control of Sternechus subsignatus Boheman (Coleoptera: Curculionidae in the early stages of development of soybean

    Directory of Open Access Journals (Sweden)

    Augusto S. Casmuz

    Full Text Available Sternechus subsignatus Boheman, 1836 (Curculionidae: Sternechini es una de las plagas de la soja más importantes en el noroeste argentino (NOA. Se trata de un insecto de gran potencial de daño, dado que tanto la larva como el adulto causan perjuicio al cultivo de soja. El manejo de S. subsignatus es difícil principalmente por sus características comportamentales y las particularidades de su biología. En busca de una alternativa de control, se estudió el uso de productos químicos insecticidas para el tratamiento de semillas de soja como método de protección del cultivo en las primeras etapas de su desarrollo. Se evaluaron tres principios activos en diferentes dosis: tiametoxan, acetamiprid e imidacloprid, más un testigo, durante tres campañas: 2002/2003, 2006/2007 y 2007/2008. El parámetro evaluado fue el porcentaje de plantas dañadas. Las evaluaciones se hicieron en diferentes tiempos, a partir de la fecha de siembra del ensayo. El activo que ofreció mayor control fue tiametoxan 35% FS, en todos los ensayos evaluados, brindando una protección adecuada hasta las tres semanas posteriores a la siembra del cultivo.Sternechus subsignatus Boheman, 1836 (Curculionidae: Sternechini is one of the most important soybean pests in Northwestern Argentina (NOA. It has potential for considerable damage, since both larvae and adults are harmful to the crop. S. subsignatus management is difficult primarily due to its behaviour and peculiarities of its biology. In the search for an alternative to control the pest, we studied the use of chemical insecticides for soybean seed treatment as a method for protecting the crop in its early development stages. Three products at different doses, thiamethoxan, acetamiprid and imidacloprid, and a control were evaluated during three crop seasons: 2002/2003, 2006/2007 and 2007/2008. The evaluated parameter was the percentage of damaged plants. Assessments were made at different times, from trial sowing date

  6. A fully automatic processing chain to produce Burn Scar Mapping products, using the full Landsat archive over Greece

    Science.gov (United States)

    Kontoes, Charalampos; Papoutsis, Ioannis; Herekakis, Themistoklis; Michail, Dimitrios; Ieronymidi, Emmanuela

    2013-04-01

    Remote sensing tools for the accurate, robust and timely assessment of the damages inflicted by forest wildfires provide information that is of paramount importance to public environmental agencies and related stakeholders before, during and after the crisis. The Institute for Astronomy, Astrophysics, Space Applications and Remote Sensing of the National Observatory of Athens (IAASARS/NOA) has developed a fully automatic single and/or multi date processing chain that takes as input archived Landsat 4, 5 or 7 raw images and produces precise diachronic burnt area polygons and damage assessments over the Greek territory. The methodology consists of three fully automatic stages: 1) the pre-processing stage where the metadata of the raw images are extracted, followed by the application of the LEDAPS software platform for calibration and mask production and the Automated Precise Orthorectification Package, developed by NASA, for image geo-registration and orthorectification, 2) the core-BSM (Burn Scar Mapping) processing stage which incorporates a published classification algorithm based on a series of physical indexes, the application of two filters for noise removal using graph-based techniques and the grouping of pixels classified as burnt to form the appropriate pixels clusters before proceeding to conversion from raster to vector, and 3) the post-processing stage where the products are thematically refined and enriched using auxiliary GIS layers (underlying land cover/use, administrative boundaries, etc.) and human logic/evidence to suppress false alarms and omission errors. The established processing chain has been successfully applied to the entire archive of Landsat imagery over Greece spanning from 1984 to 2012, which has been collected and managed in IAASARS/NOA. The number of full Landsat frames that were subject of process in the framework of the study was 415. These burn scar mapping products are generated for the first time to such a temporal and spatial

  7. Occurrence of ozone anomalies over cloudy areas in TOMS version-7 level-2 data

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    X. Liu

    2003-01-01

    Full Text Available This study investigates anomalous ozone distributions over cloudy areas in Nimbus-7 (N7 and Earth-Probe (EP TOMS version-7 data and analyzes the causes for ozone anomaly formation. A 5°-longitude by 5°-latitude region is defined to contain a Positive Ozone Anomaly (POA or Negative Ozone Anomaly (NOA if the correlation coefficient between total ozone and reflectivity is > 0.5 or -0.5. The average fractions of ozone anomalies among all cloud fields are 31.8 ± 7.7% and 35.8 ± 7.7% in the N7 and EP TOMS data, respectively. Some ozone anomalies are caused by ozone retrieval errors, and others are caused by actual geophysical phenomena. Large cloud-height errors are found in the TOMS version-7 algorithm in comparison to the Temperature Humidity Infrared Radiometer (THIR cloud data. On average, cloud-top pressures are overestimated by ~200 hPa (THIR cloud-top pressure 200 hPa for high-altitude clouds and underestimated by ~150 hPa for low-altitude clouds (THIR cloud-top pressure > 750 hPa. Most tropical NOAs result from negative errors induced by large cloud-height errors, and most tropical POAs are caused by positive errors due to intra-cloud ozone absorption enhancement. However, positive and negative errors offset each other, reducing the ozone anomaly occurrence in TOMS data. Large ozone/reflectivity slopes for mid-latitude POAs show seasonal variation consistent with total ozone fluctuation, indicating that they result mainly from synoptic and planetary wave disturbances. POAs with an occurrence fraction of 30--60% occur in regions of marine stratocumulus off the west coast of South Africa and off the west coast of South America. Both fractions and ozone/reflectivity slopes of these POAs show seasonal variations consistent with that in the tropospheric ozone. About half the ozone/reflectivity slope can be explained by ozone retrieval errors over clear and cloudy areas. The remaining slope may result from there being more ozone production

  8. An ancient conserved role for prion protein in learning and memory

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    Patricia L. A. Leighton

    2018-01-01

    Full Text Available The misfolding of cellular prion protein (PrPC to form PrP Scrapie (PrPSc is an exemplar of toxic gain-of-function mechanisms inducing propagated protein misfolding and progressive devastating neurodegeneration. Despite this, PrPC function in the brain is also reduced and subverted during prion disease progression; thus understanding the normal function of PrPC in healthy brains is key. Disrupting PrPC in mice has led to a myriad of controversial functions that sometimes map onto disease symptoms, including a proposed role in memory or learning. Intriguingly, PrPC interaction with amyloid beta (Aβ oligomers at synapses has also linked its function to Alzheimer's disease and dementia in recent years. We set out to test the involvement of PrPC in memory using a disparate animal model, the zebrafish. Here we document an age-dependent memory decline in prp2−/− zebrafish, pointing to a conserved and ancient role of PrPC in memory. Specifically, we found that aged (3-year-old prp2−/− fish performed poorly in an object recognition task relative to age-matched prp2+/+ fish or 1-year-old prp2−/− fish. Further, using a novel object approach (NOA test, we found that aged (3-year-old prp2−/− fish approached the novel object more than either age-matched prp2+/+ fish or 1-year-old prp2−/− fish, but did not have decreased anxiety when we tested them in a novel tank diving test. Taken together, the results of the NOA and novel tank diving tests suggest an altered cognitive appraisal of the novel object in the 3-year-old prp2−/− fish. The learning paradigm established here enables a path forward to study PrPC interactions of relevance to Alzheimer's disease and prion diseases, and to screen for candidate therapeutics for these diseases. The findings underpin a need to consider the relative contributions of loss- versus gain-of-function of PrPC during Alzheimer's and prion diseases, and have implications upon the prospects of several

  9. Evaluation results after seven years of operation for the permanent Hellenic Seismological Network of Crete (HSNC).

    Science.gov (United States)

    Vallianatos, F.; Hloupis, G.; Papadopoulos, I.

    2012-04-01

    The Hellenic arc and the adjacent areas of the Greek mainland are the most active in western Eurasia and some of the most seismically active zones of the world. The seismicity of South Aegean is extremely high and is characterised by the frequent occurrence of large shallow and intermediate depth earthquakes. Until 2004, the installed seismological stations from several providers (NOA, GEOFON, MEDNET) provide average interstation distance around 130km resulting to catalogues with minimum magnitude of completeness (Mc) equals to 3.7. Towards to the direction of providing dense and state of the art instrumental coverage of seismicity in the South Aegean, HSNC begun its operation in 2004. Today it consists of (12) permanent seismological stations equipped with short period and broadband seismographs coupled with 3rd generation 24bit data loggers as well as from (2) accelerographs . The addition of HSNC along with combined use of all the active networks in South Aegean area (NOA, GEOFON, AUTH) decrease the average interstation distance to 60km and provide catalogues with Mc≥3.2. Data transmission and telemetry is implemented by a hybrid network consisting of dedicated wired ADSL links as well as VSAT links by using a unique private satellite hub. Real time data spread over collaborating networks (AUTH) and laboratories (Department of Earth Science - UCL) while at the same time, events are appended automatically and manually to EMSC database. Additional value to the network is provided by means of prototype systems which deployed in-situ for the purposes of: a) Acquiring aftershock data in the minimum time after main event. This is a mobile seismological network called RaDeSeis (Rapid Deployment Seismological network) which consists of a central station acting also as the central communication hub and wifi coupled mobile stations. b) The development of dedicated hardware and software solutions for rapid installation times (around 1 hour for each station) leading to

  10. Predictive value of serum Inhibin-B levels as an indicator of the presence of testicular spermatozoa in non-obstructive azoospermia

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    Marwan Alhalabi

    2016-12-01

    Full Text Available Introduction: Inhibin-B is glycoproteins of the transforming growth factor-β superfamily, is produced almost exclusively by the Sertoli cells and has been proposed as direct markers of their function and indirect markers of spermatogenesis. Our objective was to evaluate the predictive value of serum Inhibin-B levels as an indicator of the presence of testicular spermatozoa in non-obstructive azoospermia (NOA, compared with other markers such as FSH and testicular volume. Material and methods: A total of 228 patients with idiopathic non-obstructive azoospermia (NOA were recruited in this prospective study. Inhibin-B in serum has been evaluated before sperm retrieval by Enzyme-Linked Immuno-Sorbent Assay (Elisa, in addition to FSH and testosterone. Testicular volume was measured by sonography. Testicular Fine Needle Aspiration (FNA and Testicular Sperm Extraction (TESE were performed for sperm retrieval. The patients were classified according to the presence or absence of Testicular spermatozoa into two groups (I and II respectively. Results: Spermatozoa were retrieved in 87 patients (38.16%, classified as group I and were absent in 141 patients (61.84% classified as group II. Mean serum Inhibin-B ± SD was significantly higher in group I than in group II, 71.77 versus 27.49 respectively (P < 0.001. The odds ratio of Inhibin-B for success of sperm retrieval was 1.0409 (95% CI: 1.0286–1.0533. Serum Inhibin-B demonstrated that the best inhibin-B value threshold for discriminating between successful and failed sperm retrieval was 35 pg/ml, with a sensitivity of 75.86 (95% Confidence interval [CI]: 65.5–84.4 and specificity of 80.85 (CI: 73.4–87.0 for the prediction of the presence of testicular spermatozoa as determined by the receiver operating characteristic (ROC curve analysis and area under curve (AUC. Conclusions: Inhibin-B might be a predictive marker of persistent spermatogenesis in the men with non-obstructive azoospermia.

  11. Bodrum-Kos (Turkey-Greece) Mw 6.6 earthquake and tsunami of 20 July 2017: a test for the Mediterranean tsunami warning system

    Science.gov (United States)

    Heidarzadeh, Mohammad; Necmioglu, Ocal; Ishibe, Takeo; Yalciner, Ahmet C.

    2017-12-01

    Various Tsunami Service Providers (TSPs) within the Mediterranean Basin supply tsunami warnings including CAT-INGV (Italy), KOERI-RETMC (Turkey), and NOA/HL-NTWC (Greece). The 20 July 2017 Bodrum-Kos (Turkey-Greece) earthquake (Mw 6.6) and tsunami provided an opportunity to assess the response from these TSPs. Although the Bodrum-Kos tsunami was moderate (e.g., runup of 1.9 m) with little damage to properties, it was the first noticeable tsunami in the Mediterranean Basin since the 21 May 2003 western Mediterranean tsunami. Tsunami waveform analysis revealed that the trough-to-crest height was 34.1 cm at the near-field tide gauge station of Bodrum (Turkey). Tsunami period band was 2-30 min with peak periods at 7-13 min. We proposed a source fault model for this tsunami with the length and width of 25 and 15 km and uniform slip of 0.4 m. Tsunami simulations using both nodal planes produced almost same results in terms of agreement between tsunami observations and simulations. Different TSPs provided tsunami warnings at 10 min (CAT-INGV), 19 min (KOERI-RETMC), and 18 min (NOA/HL-NTWC) after the earthquake origin time. Apart from CAT-INGV, whose initial Mw estimation differed 0.2 units with respect to the final value, the response from the other two TSPs came relatively late compared to the desired warning time of 10 min, given the difficulties for timely and accurate calculation of earthquake magnitude and tsunami impact assessment. It is argued that even if a warning time of 10 min was achieved, it might not have been sufficient for addressing near-field tsunami hazards. Despite considerable progress and achievements made within the upstream components of NEAMTWS (North East Atlantic, Mediterranean and Connected seas Tsunami Warning System), the experience from this moderate tsunami may highlight the need for improving operational capabilities of TSPs, but more importantly for effectively integrating civil protection authorities into NEAMTWS and strengthening

  12. The Hellenic National Tsunami Warning Centre (HL-NTWC): Recent updates and future developments

    Science.gov (United States)

    Melis, Nikolaos S.; Charalampakis, Marinos

    2014-05-01

    The Hellenic NTWC (HL-NTWC) was established officially by Greek Law in September 2010. HL-NTWC is hosted at the National Observatory of Athens, Institute of Geodynamics (NOA-IG), which also operates a 24/7 earthquake monitoring service in Greece and coordinates the newly established Hellenic Unified National Seismic Network. NOA-IG and HL-NTWC Operational Centre is linked to the Civil Protection Operational Centre and serves as the official alerting agency to the General Secretariat for Civil Protection in Greece, regarding earthquake events and tsunami watch. Since August 2012, HL-NTWC acts as Candidate Tsunami Watch Provider (CTWP) under the UNESCO IOC - ICG NEAMTWS tsunami warning system (NEAM: North-Eastern Atlantic, the Mediterranean and connected seas) and offers its services to the NEAMTWS system. HL-NTWC has participated in all Communication Test Exercises (CTE) under NEAMTWS and also it has provided tsunami scenarios for extended system testing exercises such as NEAMWAVE12. Some of the recent developments at HL-NTWC in Greece include: deployment of new tide gauge stations for tsunami watch purposes, computation of tsunami scenarios and extending the database in use, improving alerting response times, earthquake magnitude estimation and testing newly established software modules for tsunami and earthquake alerting (i.e. Early-Est, SeisComP3 etc.) in Greece and the Eastern Mediterranean. Although funding today is limited, an advantage of the participation in important EC funded research projects, i.e. NERIES, NERA, TRANSFER, NEAMTIC and ASTARTE, demonstrates that collaboration of top class Research Institutions that care to produce important and useful results in the research front in Europe, can facilitate towards developing and operating top class Operational Centers, useful for Civil Protection purposes in regions in need. Last, it is demonstrated that HL-NTWC collaboration with important key role Research Centers in the Security and Safety issues (e

  13. Brotes de babesiosis y anaplasmosis bovina diagnosticados en el INTA Salta, Argentina: período 2006-2016

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    ARAOZ V

    2017-12-01

    Full Text Available Se realizó un estudio retrospectivo de brotes de babesiosis y anaplasmosis (tristeza parasitaria bovina, TPB ocurridos entre 2006 y 2016 en el Noroeste argentino (NOA para evaluar algunos aspectos epidemiológicos y clínicos de estas enfermedades. De 4.398 muestras para diagnóstico, 238 (5,4% tuvieron sospechas de TPB, las cuales se confirmaron en 106 (44,3% casos por observación microscópica de los agentes causales. Cuarenta y siete (44,3% brotes se debieron a Anaplasma marginale, 40 (37,7% a Babesia bovis y 14 (13,2% a Babesia bigemina. En cinco (4,7% focos de babesiosis no se determinó la especie causal de Babesia. Los brotes se diagnosticaron en 62 establecimientos ganaderos de cuatro provincias (Salta, Jujuy, Santiago del Estero y Chaco. La mayoría ocurrieron en verano y otoño, con máxima incidencia en abril y nula en setiembre para ambas noxas. Las vacas adultas fueron la categoría de ganado más afectada. En 58% (61/106 de los brotes murió al menos un bovino, con un número promedio de cuatro muertes por brote. Se concluye que la TPB continúa incidiendo negativamente en la producción bovina del NOA. SUMMARY. Bovine babesiosis and anaplasmosis outbreaks diagnosed at INTA Salta, Argentina: 2006-2016. A retrospective study of babesiosis and anaplasmosis outbreaks (tick fever, TF was made, which occurred from 2006 to 2016 in Northwest Argentina (NWA, to evaluate clinical and epidemiological aspects of these diseases. From 4,398 specimens, 238 (5.4% were associated with suspicions of TF and 106 of these cases (44.3% were confirmed as TF outbreaks by microscopic observation of causal agents. Forty seven (44.3% were due to Anaplasma marginale, 40 (37.7% to Babesia bovis and 14 (13.2% to Babesia bigemina. In five (4.7% outbreaks of babesiosis, Babesia species were not determined. Outbreaks were diagnosed at 62 different cattle ranches in four provinces (Salta, Jujuy, Santiago del Estero and Chaco. The outbreaks occurred mostly during

  14. Electrically Tunable Binary-Phase Fresnel Lens Based on Polymer Dispersed Liquid Crystal

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    Hui LI

    2017-08-01

    Full Text Available This is a proposal for a Fresnel lens with an electrically tunable binary-phase made of polymer dispersed liquid crystal (PDLC, which has relatively fast response time and low applied voltage. Simple fabrication is the major advantage of the proposed method. In this study, NOA65 and E7 were utilized with weight ratios of 60 wt.%: 40 wt.%. There was also the utilization of a relatively low intensity UV-light, 0.53 mW/cm2. The duration time of exposure was about 30 hours. The performance improvement of the Fresnel lens resulted from the infiltration of large LC droplet into the PDLC film. The phenomenon of black cross strip patterns could be explained with the use of the electro-hydrodynamics theory. The diffraction efficiency of the proposed lens was from 31.1 % to 41 % with the changes of externally applied voltage. This work presents an effective approach to get relatively complete phase separation in PDLC. The proposed method also provides great potential in developing high performance Fresnel lens.DOI: http://dx.doi.org/10.5755/j01.ms.23.2.16317

  15. Handbook on Special Works. Technological Lines of Industrial Enterprises. Part 1,

    Science.gov (United States)

    1979-10-16

    welded parts of conduits/manifolds made of carboa steel. ite3l) ipyou3or ymae no MCH 120.60 ’ yrjioM 90. f6 ) iI 45 . P 4-50 0M 2 5) r1LyTe noA yr.aio...14.68 16.4 22,32 30.44 44.32 67. f6 400 17.04 19.0 1 27.32 40,94 62.33 103.6 smO 24.71 24.7 36.84 67.79 .36 1 .x 60 32.91 32.91 45,34 94,2 118,42 I J...flanges). Pr _____’ ( ’) 0.2 3 2.5 4 l Dy D, (.) acca mae& 06 mac OWiacamae " [0 CTS - e La acOTa" CTS; KIO CTA, 0aO *TS xIvold c Ian u8 KAH K - . "l

  16. Auxin as an inducer of asymmetrical division generating the subsidiary cells in stomatal complexes of Zea mays.

    Science.gov (United States)

    Livanos, Pantelis; Giannoutsou, Eleni; Apostolakos, Panagiotis; Galatis, Basil

    2015-01-01

    The data presented in this work revealed that in Zea mays the exogenously added auxins indole-3-acetic acid (IAA) and 1-napthaleneacetic acid (NAA), promoted the establishment of subsidiary cell mother cell (SMC) polarity and the subsequent subsidiary cell formation, while treatment with auxin transport inhibitors 2,3,5-triiodobenzoic acid (TIBA) and 1-napthoxyacetic acid (NOA) specifically blocked SMC polarization and asymmetrical division. Furthermore, in young guard cell mother cells (GMCs) the PIN1 auxin efflux carriers were mainly localized in the transverse GMC faces, while in the advanced GMCs they appeared both in the transverse and the lateral ones adjacent to SMCs. Considering that phosphatidyl-inositol-3-kinase (PI3K) is an active component of auxin signal transduction and that phospholipid signaling contributes in the establishment of polarity, treatments with the specific inhibitor of the PI3K LY294002 were carried out. The presence of LY294002 suppressed polarization of SMCs and prevented their asymmetrical division, whereas combined treatment with exogenously added NAA and LY294002 restricted the promotional auxin influence on subsidiary cell formation. These findings support the view that auxin is involved in Z. mays subsidiary cell formation, probably functioning as inducer of the asymmetrical SMC division. Collectively, the results obtained from treatments with auxin transport inhibitors and the appearance of PIN1 proteins in the lateral GMC faces indicate a local transfer of auxin from GMCs to SMCs. Moreover, auxin signal transduction seems to be mediated by the catalytic function of PI3K.

  17. Invasion-Flowback Processes During Hydraulic Fracturing Well Interference

    Science.gov (United States)

    Kenzhekhanov, Shaken; He, Kai; Xu, Liang; Lord, Paul; Lozano, Martin; Neeves, Keith; Yin, Xiaolong

    2017-11-01

    Drainage-imbibition cycles that simulate hydraulic fracturing fluid's invasion and flowback during well interference were investigated using NOA81 microfluidic micromodels. Well interference is quite common in unconventional oil and gas fields. It is not unusual for the fracturing fluid injected into a well to be discovered in a nearby well. Normally, the effect of such interference is considered to be negative, as fracturing fluid will be imbibed into the porous rock and block the flow path of hydrocarbons. However, field data show that some interferences are beneficial, and microfluidic experiments presented in this study show that surfactant in the fracturing fluid may be a reason for the observed positive interference. Two fluid drainage-imbibition cycles were conducted in micromodels. The first cycle simulates fracturing of the old well and the second cycle simulates fluid invasion from the new well into the old well's fracture network. The experimental data show that while most such interferences indeed can cause production loss, when the old well's fracturing fluid does not contain surfactant yet the new well's fracturing fluid does, interference can be positive, as the residual water saturation in the porous medium is effectively reduced by surfactants.

  18. New technique for real-time distortion-invariant multiobject recognition and classification

    Science.gov (United States)

    Hong, Rutong; Li, Xiaoshun; Hong, En; Wang, Zuyi; Wei, Hongan

    2001-04-01

    A real-time hybrid distortion-invariant OPR system was established to make 3D multiobject distortion-invariant automatic pattern recognition. Wavelet transform technique was used to make digital preprocessing of the input scene, to depress the noisy background and enhance the recognized object. A three-layer backpropagation artificial neural network was used in correlation signal post-processing to perform multiobject distortion-invariant recognition and classification. The C-80 and NOA real-time processing ability and the multithread programming technology were used to perform high speed parallel multitask processing and speed up the post processing rate to ROIs. The reference filter library was constructed for the distortion version of 3D object model images based on the distortion parameter tolerance measuring as rotation, azimuth and scale. The real-time optical correlation recognition testing of this OPR system demonstrates that using the preprocessing, post- processing, the nonlinear algorithm os optimum filtering, RFL construction technique and the multithread programming technology, a high possibility of recognition and recognition rate ere obtained for the real-time multiobject distortion-invariant OPR system. The recognition reliability and rate was improved greatly. These techniques are very useful to automatic target recognition.

  19. UV Irradiance Enhancements by Scattering of Solar Radiation from Clouds

    Directory of Open Access Journals (Sweden)

    Uwe Feister

    2015-08-01

    Full Text Available Scattering of solar radiation by clouds can reduce or enhance solar global irradiance compared to cloudless-sky irradiance at the Earth’s surface. Cloud effects to global irradiance can be described by Cloud Modification Factors (CMF. Depending on strength and duration, irradiance enhancements affect the energy balance of the surface and gain of solar power for electric energy generation. In the ultraviolet region, they increase the risk for damage to living organisms. Wavelength-dependent CMFs have been shown to reach 1.5 even in the UV-B region at low altitudes. Ground-based solar radiation measurements in the high Andes region at altitudes up to 5917 m a.s.l showed cloud-induced irradiance enhancements. While UV-A enhancements were explained by cloud scattering, both radiation scattering from clouds and Negative Ozone Anomalies (NOA have been discussed to have caused short-time enhancement of UV-B irradiance. Based on scenarios using published CMF and additional spectroradiometric measurements at a low-altitude site, the contribution of cloud scattering to the UV-B irradiance enhancement in the Andes region has been estimated. The range of UV index estimates converted from measured UV-B and UV-A irradiance and modeled cloudless-sky ratios UV-B/erythemal UV is compatible with an earlier estimate of an extreme UV index value of 43 derived for the high Andes.

  20. Mathematics and culture in Micronesia

    Directory of Open Access Journals (Sweden)

    A. J. (Sandy Dawson

    2015-07-01

    Full Text Available Wheatley and Frieze‟s book, Walk Out Walk On, provides the conceptual framework for an examination of Project MACIMISE, a National Science Foundation funded project that focused on the languages and cultural practices of nine Pacific islands and the state of Hawai„i. MACIMISE, pronounced as if spelled „maximize‟, is a 5-year Project. The Project‟s task is the development of elementary school mathematics curriculum units sensitive to local mathematical thought and experience. There were twenty-one participants (who call themselves the Macimisers in the Project. The participants were educated in ethnographic and anthropological research strategies to enable them to retrieve/uncover cultural practices extant in the communities where they lived. This academics work was accomplished partially via distance learning when the participants were registered in advanced degree programs at the University of Hawai„i—Mānoa. In this paper, the Project is analyzed in terms of the concepts (scaling across, start anywhere—follow it everywhere, intervention to friendship, the art of hosting and the use of circle advanced by Wheatley and Frieze.

  1. CAPTAIN-Miner@@a. Neutrino-Argon Scattering in a Medium-Energy Neutrino Beam

    International Nuclear Information System (INIS)

    Mauger, Christopher M.

    2015-01-01

    The NuMI facility at Fermilab is currently providing an extremely intense beam of neutrinos for the NO@@A, MINER@@A and MINOS+ experiments. By installing the 5-ton CAPTAIN liquid argon TPC in front of the MINER@@A detector in the NuMI beamline and combining the data from the CAPTAIN, MINER@@A and MINOS+ detectors, a broad program of few-GeV neutrino cross section measurements on argon can be pursued. These measurements will be extremely helpful for future oscillation experiments. By directly comparing the cross sections on argon to MINER@@A@@@s scintillator (CH) target, a new level of precision can be achieved in the measurements of the effects of the nucleus on neutrino interactions. These effects are of interest to not only the particle physics but also the nuclear physics community. This document describes in detail the physics goals of the CAPTAIN-MINER@@A experiment, in addition to a first estimate of the technical resources required to install, commission and operate the CAPTAIN detector in front of the MINERVA detector.

  2. Conhecimentos e atitudes de adolescentes de uma escola pública sobre a transmissão sexual do HIV

    Directory of Open Access Journals (Sweden)

    Ana Clara Patriota Chaves

    Full Text Available Os objetivos da pesquisa foram descrever conhecimentos sobre a transmissão do HIV/AIDS e analisar o comportamento sexual e atitudes frente ao uso do preservativo entre adolescentes. Pesquisa exploratória realizada, em 2009, com 234 adolescentes de uma escola em Fortaleza-CE. Utilizou-se questionário semiestruturado e escala de Likert. Os resultados mostraram que 46,6% da amostra já haviam iniciado a vida sexual; 40,7% e 29,5% não usaram preservativo na primeira nem na última relação sexual respectivamente, em decorrência de diversos motivos como não ter o preservativo no momento (27,3%; uso de pílula anticoncepcional (15,2% e confiança no(a parceiro(a (15,2%. Os adolescentes apresentaram dúvidas sobre a transmissão do HIV. As mulheres se mostraram mais favoráveis ao uso do preservativo do que os homens. Conclui-se que o início da vida sexual precoce, as dúvidas sobre a transmissão do HIV e a não utilização efetiva do preservativo são alguns dos fatores que compõem a vulnerabilidade dos jovens.

  3. Microstructured surfaces engineered using biological templates: a facile approach for the fabrication of superhydrophobic surfaces

    Directory of Open Access Journals (Sweden)

    DUSAN LOSIC

    2008-10-01

    Full Text Available The fabrication of microstructured surfaces using biological templates was investigated with the aim of exploring of a facile and low cost approach for the fabrication of structured surfaces with superhydrophobic properties. Two soft lithographic techniques, i.e., replica moulding and nano-imprinting, were used to replicate the surfaces of a biological substrate. Leaves of the Agave plant (Agave attenuate, a cost-free biological template, were used as a model of a biosurface with superhydrophobic properties. The replication process was performed using two polymers: an elastomeric polymer, poly(dimethylsiloxane (PDMS, and a polyurethane (PU based, UV-curable polymer (NOA 60. In the first replication step, negative polymer replicas of the surface of leaves were fabricated, which were used as masters to fabricate positive polymer replicas by moulding and soft imprinting. The pattern with micro and nanostructures of the surface of the leaf possesses superhydrophobic properties, which was successfully replicated into both polymers. Finally, the positive replicas were coated with a thin gold film and modified with self-assembled monolayers (SAMs to verify the importance of the surface chemistry on the hydrophobic properties of the fabricated structures. Wetting (contact angle and structural (light microscopy and scanning electron microscopy characterisation was performed to confirm the hydrophobic properties of the fabricated surfaces (> 150°, as well as the precision and reproducibility of the replication process.

  4. Deriving Tools from Real-time Runs: A New CCMC Support for SEC and AFWA

    Science.gov (United States)

    Hesse, Michael; Rastatter, Lutz; MacNeice, Peter; Kuznetsova, Masha

    2008-01-01

    The Community Coordinated Modeling Center (CCMC) is a US inter-agency activity aiming at research in support of the generation of advanced space weather models. As one of its main functions. the CCMC provides to researchers the use of space science models, even if they are not model owners themselves. The second focus of CCMC activities is on validation and verification of space weather models. and on the transition of appropriate models to space weather forecast centers. As part of the latter activity. the CCMC develops real-time simulation systems that stress models through routine execution. A by-product of these real-time calculations is the ability to derive model products, which may be useful for space weather operators. After consultations with NOA/SEC and with AFWA, CCMC has developed a set of tools as a first step to make real-time model output useful to forecast centers. In this presentation, we will discuss the motivation for this activity, the actions taken so far, and options for future tools from model output.

  5. Evaluation of the performance of DIAS ionospheric forecasting models

    Directory of Open Access Journals (Sweden)

    Tsagouri Ioanna

    2011-08-01

    Full Text Available Nowcasting and forecasting ionospheric products and services for the European region are regularly provided since August 2006 through the European Digital upper Atmosphere Server (DIAS, http://dias.space.noa.gr. Currently, DIAS ionospheric forecasts are based on the online implementation of two models: (i the solar wind driven autoregression model for ionospheric short-term forecast (SWIF, which combines historical and real-time ionospheric observations with solar-wind parameters obtained in real time at the L1 point from NASA ACE spacecraft, and (ii the geomagnetically correlated autoregression model (GCAM, which is a time series forecasting method driven by a synthetic geomagnetic index. In this paper we investigate the operational ability and the accuracy of both DIAS models carrying out a metrics-based evaluation of their performance under all possible conditions. The analysis was established on the systematic comparison between models’ predictions with actual observations obtained over almost one solar cycle (1998–2007 at four European ionospheric locations (Athens, Chilton, Juliusruh and Rome and on the comparison of the models’ performance against two simple prediction strategies, the median- and the persistence-based predictions during storm conditions. The results verify operational validity for both models and quantify their prediction accuracy under all possible conditions in support of operational applications but also of comparative studies in assessing or expanding the current ionospheric forecasting capabilities.

  6. 2×2 polymeric electro-optic MZI switch using multimode interference couplers

    Science.gov (United States)

    Li, H. P.; Liao, J. K.; Tang, X. G.; Lu, R. G.; Liu, Y. Z.

    2009-11-01

    We present the design of a 2×2 photonic switch operating at 1.55-μm wavelength using electro-optic (EO) polymer waveguides. A Mach-Zehnder interferometer (MZI) is used to implement the proposed switch in which two identical 2×2 multimode interference (MMI) couplers are connected by two identical parallel single mode waveguides (two MZI arms). These two single-mode waveguides with electrodes allow modulating the phase difference between the two MZI arms based on the EO effect. In the proposed switch, the EO polymer, IPC-E/polysulfone, is used for the core layer of optical waveguides. UV15 and NOA61 are employed for the lower and upper cladding layers, respectively. The singlemode waveguide structure and 2×2 MMI coupler have been designed and analyzed for the EO switch. Device performance has been simulated using the beam propagation method. It is found that the switch performance is most sensitive to the MMI width and less sensitive to the MMI length. Optimized structure has been obtained for the 2×2 polymeric EO switch, which has a crosstalk level better than -25 dB and insertion loss lower than -1.8 dB. This performance makes the switch a potential candidate for practical use in photonic systems.

  7. Flexible Bragg reflection waveguide devices fabricated on a plastic substrate

    Science.gov (United States)

    Kim, Kyung-Jo; Yi, Jeong-Ah; Oh, Min-Cheol; Noh, Young-Ouk; Lee, Hyung-Jong

    2007-09-01

    Bragg reflecting waveguide devices are fabricated on a flexible substrate by using a post lift-off process in order to provide highly uniform grating patterns on a wide range. In this process, the flexible substrate spin-coated on silicon wafer is released after the final fabrication process of chip dicing. The fabricated flexible Bragg reflector shows very sharp transmission spectrum with 3-dB bandwidth of 0.1 nm and 10-dB bandwidth of 0.4 nm, which proves the Bragg reflector has excellent uniformity. To achieve athermal operation of the flexible Bragg reflector, thermal expansion property of the plastic substrate is controlled by the thickness of two polymer materials constructing the plastic substrate. The flexible substrate with 0.7-μm SU-8 layers sandwiching 100-μm NOA61 layer provides an optimized thermal expansion property to compensate the thermo-optic effect of the waveguide made of ZPU polymer. The temperature dependence of the Bragg reflector is decreased to -0.011 nm/°C through the incorporation of the plastic substrate.

  8. Analysis of Light Gathering Abilities of Dynamically Solidified Micro-lenses, and Their Implementation to Improve Sensitivity of Fluorescent PCR Micro-detectors.

    Science.gov (United States)

    Wu, Jian; Guo, Wei; Wang, Chunyan; Yu, Kuanxin; Chen, Tao; Li, Yinghui

    2015-06-01

    Fluorescent polymerase chain reaction (PCR) is becoming the preferred method of quantitative analysis due to its high specificity and sensitivity. We propose to use a new kind of micro-lens, dynamically solidified with optic glue, to improve the sensitivity of fluorescent PCR micro-detector. We developed light ray track equations for these lenses and used them to calculate relative light intensity distribution curve for stimulation lenses and illumination point probability distribution curve for detection lenses. We manufactured dynamically solidified micro-lenses using optic glue NOA61, and measured their light gathering ability. Lenses with radius/thickness (R/H) ratio of 4 reached light focusing ratio of 3.85 (stimulation lens) and photon collection efficiency of 0.86 (detection lens). We then used dynamically solidified lenses in PCR fluorescence micro-detector and analyzed their effect on the detector sensitivity. We showed that the use of dynamically solidified micro-lenses with R/H = 4 resulted in over 4.4-fold increased sensitivity of the detector.

  9. Autonomous management of a recursive area hierarchy for large scale wireless sensor networks using multiple parents

    Energy Technology Data Exchange (ETDEWEB)

    Cree, Johnathan Vee [Washington State Univ., Pullman, WA (United States); Delgado-Frias, Jose [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-03-01

    Large scale wireless sensor networks have been proposed for applications ranging from anomaly detection in an environment to vehicle tracking. Many of these applications require the networks to be distributed across a large geographic area while supporting three to five year network lifetimes. In order to support these requirements large scale wireless sensor networks of duty-cycled devices need a method of efficient and effective autonomous configuration/maintenance. This method should gracefully handle the synchronization tasks duty-cycled networks. Further, an effective configuration solution needs to recognize that in-network data aggregation and analysis presents significant benefits to wireless sensor network and should configure the network in a way such that said higher level functions benefit from the logically imposed structure. NOA, the proposed configuration and maintenance protocol, provides a multi-parent hierarchical logical structure for the network that reduces the synchronization workload. It also provides higher level functions with significant inherent benefits such as but not limited to: removing network divisions that are created by single-parent hierarchies, guarantees for when data will be compared in the hierarchy, and redundancies for communication as well as in-network data aggregation/analysis/storage.

  10. Mechanical design of ceramic beam tube braze joints for NOvA kicker magnets

    Energy Technology Data Exchange (ETDEWEB)

    Ader, C.R.; Reilly, R.E.; Wilson, J.H.; /Fermilab

    2010-05-01

    The NO?A Experiment will construct a detector optimized for electron neutrino detection in the existing NuMI neutrino beam. The NuMI beam line is capable of operating at 400 kW of primary beam power and the upgrade will allow up to 700 kW. Ceramic beam tubes are utilized in numerous kicker magnets in different accelerator rings at Fermi National Accelerator Laboratory. Kovar flanges are brazed onto each beam tube end, since kovar and high alumina ceramic have similar expansion curves. The tube, kovar flange, end piece, and braze foil alloy brazing material are stacked in the furnace and then brazed. The most challenging aspect of fabricating kicker magnets in recent years have been making hermetic vacuum seals on the braze joints between the ceramic and flange. Numerous process variables can influence the robustness of conventional metal/ceramic brazing processes. The ceramic-filler metal interface is normally the weak layer when failure does not occur within the ceramic. Differences between active brazing filler metal and the moly-manganese process will be discussed along with the applicable results of these techniques used for Fermilab production kicker tubes.

  11. Active species in a large volume N2-O2 post-discharge reactor

    International Nuclear Information System (INIS)

    Kutasi, K; Pintassilgo, C D; Loureiro, J; Coelho, P J

    2007-01-01

    A large volume post-discharge reactor placed downstream from a flowing N 2 -O 2 microwave discharge is modelled using a three-dimensional hydrodynamic model. The density distributions of the most populated active species present in the reactor-O( 3 P), O 2 (a 1 Δ g ), O 2 (b 1 Σ g + ), NO(X 2 Π), NO(A 2 Σ + ), NO(B 2 Π), NO 2 (X), O 3 , O 2 (X 3 Σ g - ) and N( 4 S)-are calculated and the main source and loss processes for each species are identified for two discharge conditions: (i) p = 2 Torr, f = 2450 MHz, and (ii) p = 8 Torr, f = 915 MHz; in the case of a N 2 -2%O 2 mixture composition and gas flow rate of 2 x 10 3 sccm. The modification of the species relative densities by changing the oxygen percentage in the initial gas mixture composition, in the 0.2%-5% range, are presented. The possible tuning of the species concentrations in the reactor by changing the size of the connecting afterglow tube between the active discharge and the large post-discharge reactor is investigated as well

  12. National Scale Operational Mapping of Burnt Areas as a Tool for the Better Understanding of Contemporary Wildfire Patterns and Regimes

    Directory of Open Access Journals (Sweden)

    Panteleimon Xofis

    2013-08-01

    Full Text Available This paper presents the results of an operational nationwide burnt area mapping service realized over Greece for the years 2007–2011, through the implementation of the so-called BSM_NOA dedicated method developed at the National Observatory of Athens for post-fire recovery management. The method exploits multispectral satellite imagery, such as Landsat-TM, SPOT, FORMOSAT-2, WorldView and IKONOS. The analysis of fire size distribution reveals that a high number of fire events evolve to large and extremely large wildfires under favorable wildfire conditions, confirming the reported trend of an increasing fire-severity in recent years. Furthermore, under such conditions wildfires affect to a higher degree areas at high altitudes, threatening the existence of ecologically significant ecosystems. Finally, recent socioeconomic changes and land abandonment has resulted in the encroachment of former agricultural areas of limited productivity by shrubs and trees, resulting both in increased fuel availability and continuity, and subsequently increased burnability.

  13. Exogenous Melatonin Improves Plant Iron Deficiency Tolerance via Increased Accumulation of Polyamine-Mediated Nitric Oxide.

    Science.gov (United States)

    Zhou, Cheng; Liu, Zhi; Zhu, Lin; Ma, Zhongyou; Wang, Jianfei; Zhu, Jian

    2016-10-25

    Melatonin has recently been demonstrated to play important roles in the regulation of plant growth, development, and abiotic and biotic stress responses. However, the possible involvement of melatonin in Fe deficiency responses and the underlying mechanisms remained elusive in Arabidopsis thaliana . In this study, Fe deficiency quickly induced melatonin synthesis in Arabidopsis plants. Exogenous melatonin significantly increased the soluble Fe content of shoots and roots, and decreased the levels of root cell wall Fe bound to pectin and hemicellulose, thus alleviating Fe deficiency-induced chlorosis. Intriguingly, melatonin treatments induced a significant increase of nitric oxide (NO) accumulation in roots of Fe-deficient plants, but not in those of polyamine-deficient ( adc2-1 and d-arginine-treated) plants. Moreover, the melatonin-alleviated leaf chlorosis was blocked in the polyamine- and NO-deficient ( nia1nia2noa1 and c-PTIO-treated) plants, and the melatonin-induced Fe remobilization was largely inhibited. In addition, the expression of some Fe acquisition-related genes, including FIT1 , FRO2 , and IRT1 were significantly up-regulated by melatonin treatments, whereas the enhanced expression of these genes was obviously suppressed in the polyamine- and NO-deficient plants. Collectively, our results provide evidence to support the view that melatonin can increase the tolerance of plants to Fe deficiency in a process dependent on the polyamine-induced NO production under Fe-deficient conditions.

  14. From Spheric to Aspheric Solid Polymer Lenses: A Review

    Directory of Open Access Journals (Sweden)

    Kuo-Yung Hung

    2011-01-01

    Full Text Available This paper presents a new approach in the use of MEMS technology to fabricate micro-optofluidic polymer solid lenses in order to achieve the desired profile, focal length, numerical aperture, and spot size. The resulting polymer solid lenses can be applied in optical data storage systems, imaging systems, and automated optical inspection systems. In order to meet the various needs of different applications, polymer solid lenses may have a spherical or aspherical shape. The method of fabricating polymer solid lenses is different from methods used to fabricate tunable lenses with variable focal length or needing an external control system to change the lens geometry. The current trend in polymer solid lenses is toward the fabrication of microlenses with a high numerical aperture, small clear aperture (<2 mm, and high transmittance. In this paper we focus on the use of thermal energy and electrostatic force in shaping the lens profile, including both spherical and aspherical lenses. In addition, the paper discusses how to fabricate a lens with a high numerical aperture of 0.6 using MEMS and also compares the optical characteristics of polymer lens materials, including SU-8, Norland Optical Adhesive (NOA, and cyclic olefin copolymer (COC. Finally, new concepts and applications related to micro-optofluidic lenses and polymer materials are also discussed.

  15. Photoactivatable metal complexes: from theory to applications in biotechnology and medicine.

    Science.gov (United States)

    Smith, Nichola A; Sadler, Peter J

    2013-07-28

    This short review highlights some of the exciting new experimental and theoretical developments in the field of photoactivatable metal complexes and their applications in biotechnology and medicine. The examples chosen are based on some of the presentations at the Royal Society Discussion Meeting in June 2012, many of which are featured in more detail in other articles in this issue. This is a young field. Even the photochemistry of well-known systems such as metal-carbonyl complexes is still being elucidated. Striking are the recent developments in theory and computation (e.g. time-dependent density functional theory) and in ultrafast-pulsed radiation techniques which allow photochemical reactions to be followed and their mechanisms to be revealed on picosecond/nanosecond time scales. Not only do some metal complexes (e.g. those of Ru and Ir) possess favourable emission properties which allow functional imaging of cells and tissues (e.g. DNA interactions), but metal complexes can also provide spatially controlled photorelease of bioactive small molecules (e.g. CO and NO)--a novel strategy for site-directed therapy. This extends to cancer therapy, where metal-based precursors offer the prospect of generating excited-state drugs with new mechanisms of action that complement and augment those of current organic photosensitizers.

  16. Robust satellite techniques for remote sensing of seismically active areas

    Energy Technology Data Exchange (ETDEWEB)

    Tramutoli, V; Di Bello, G [Potenza Univ., Potenza (Italy). Dipt. di Ingegneria e Fisica dell' Ambiente; Pergola, N; Piscitelli, S [Consiglio Nazionale delle Ricerche, Istituto di Metodologie Avanzate di Analisi Ambientale, Potenza (Italy)

    2001-04-01

    Several satellite techniques have been recently proposed to remotely map seismically active zones and to monitor geophysical phenomena possibly associated with earthquakes. Even if questionable in terms of their effective applicability, all these techniques highlight as the major problem, still to be overcome, the high number of natural factors (independent of any seismic activity) whose variable contributions to the investigated signal can be so high as to completely mask (or simulate) the space-time anomaly possibly associated to the seismic event under study. A robust approach (RAT) has recently been proposed (and successfully applied in the field of the monitoring of the major environmental risks) which, better than other methods, seems suitable for recognising space-time anomalies in the satellite observation field also in the presence of highly variable contributions from atmospheric (transmittance), surface (emissivity and morphology) and observational (time/season, but also solar and satellite zenithal angles) conditions. This work presents the first preliminary results, based on several years of NOA A/AVHRR observations, regarding its extension to satellite monitoring of thermal anomalies possibly associated to seismically active areas of Southern Italy. The main merits of this approach are its robustness against the possibility of false events detection (specially important for this kind of applications) as well as its intrinsic exportability not only to different geographic areas but also to different satellite instrumental packages.

  17. Nitric oxide in acute brain injury: a pilot study of NO(x) concentrations in human brain microdialysates and their relationship with energy metabolism.

    Science.gov (United States)

    Carpenter, Keri L H; Timofeev, Ivan; Al-Rawi, Pippa G; Menon, David K; Pickard, John D; Hutchinson, Peter J

    2008-01-01

    This pilot microdialysis study in acute brain injury patients assessed the relationship between nitric oxide products (total nitrite plus nitrate, termed NO(x)) and energy-related molecules: glucose, lactate, pyruvate, glutamate and glycerol. Twelve patients (11 major head-injury and one subarachnoid haemorrhage) were studied, 11 of which had single catheters and one had two catheters, in the cerebral cortex. Catheters were perfused at 0.3 microL/min with CNS perfusion fluid. Collection vials were changed hourly. Microdialysates were analysed for energy-related molecules on a CMA600 or ISCUS analyser, and for NO(x) using a purge vessel (VCl3 plus HCl at 95 degrees C, purged with nitrogen) connected to a Sievers NOA 280i analyser. The mean of mean NO(x) concentration (+/- SD) for the 13 catheters was 32.7 +/- 16.8 micromol/L, and the lactate/ pyruvate ratio was 38.6 +/- 20.1. Increasing NO(x) concentrations correlated significantly with decreasing lactate/ pyruvate ratio (Spearman r = -0.79, p = 0.0065), with decreasing lactate concentration (r = -0.59, p = 0.042), and with increasing glucose concentration (r = 0.71, p = 0.018). These pilot data suggest that in injured brains, higher concentrations of nitric oxide are associated with more favourable metabolism. Nitric oxide may act beneficially by increasing blood flow and delivery of oxygen and glucose. Further patients are being recruited.

  18. Isolation and culture of leaf protoplasts from Tunisian grapes

    Directory of Open Access Journals (Sweden)

    Ahmed Mliki

    2003-09-01

    Full Text Available Experimental conditions for leaf protoplast isolation and culture were optimised for in vitro plants deriving from shoot culture of two Tunisian grape varieties, Sakasly and Muscat d’Alexandrie (Vitis vinifera L.. The best yields were obtained from leaves of 4 to 5 weeks old in vitro plants, digested for 13 hours under 25 rpm agitation with an enzymatic mixture containing 0.25 % cellulase of Aspergillus niger, 0.25 % cellulase of Penicillium funiculosum, 0.5 % cellulysin of Trichoderma viridae, and 0.2 % macerozyme R-10 of Rhizopus sp. More than 50 % of the purified protoplasts had a diameter of 30-40 μm and were rich in chloroplasts. Best aptitude for cell division was found in protoplasts immobilised in sodium alginate layers at a density of 0.5x106 cell/ml, cultivated in CPW-13 medium containing 4 mg/l of NOA and 0.88 mg/l of TDZ. The variety Muscat d’Alexandrie gave better yield whereas Sakasly showed better cell division rates. Formation of micro and macrocallus have been obtained, but the oxidation of the medium has to be solved in order to promote plant regeneration.

  19. Efficacy of Neem Oil on Cardamom Thrips, Sciothrips cardamomi Ramk., and Organoleptic Studies

    Directory of Open Access Journals (Sweden)

    Johnson Stanley

    2014-01-01

    Full Text Available The neem tree contains promising pest control substances which are effective against many pests. Oil extracted from neem seeds was used against cardamom thrips, Sciothrips cardamomi, a severe and economic pest of cardamom. Neem oil formulations, namely, Tamil Nadu Agricultural univeristy neem oil (TNAU NO (acetic acid & citric acid, were found effective against the pest with a overall damage reduction of 30% after 14 days of treatment. The percent damage reduction in capsules over control after three consecutive sprays of TNAU NO(C 2% and TNAU NO(A 2% was 78.3 and 75.2 percent, respectively. The newly extracted and unformulated neem oil, though found inferior to the formulated one, still found to cause 50% and 70% reduction in damage caused by thrips at two and three rounds of sprays, making it useful in pest management. Organoleptic tests conducted on cardamom capsules sprayed with neem oil revealed no significant difference in taste, aroma, and overall acceptability of cow milk boiled with cardamom. Thus, TNAU NO (A and C 2% was found effective against cardamom thrips with no adverse organoleptic properties and can be recommended.

  20. Evaluation of a mesoscale dispersion modelling tool during the CAPITOUL experiment

    Science.gov (United States)

    Lac, C.; Bonnardot, F.; Connan, O.; Camail, C.; Maro, D.; Hebert, D.; Rozet, M.; Pergaud, J.

    2008-12-01

    Atmospheric transport and dispersion were investigated during the CAPITOUL campaign using measurements of sulphur hexafluoride (SF6) tracer. Six releases of SF6 tracer were performed (March 9-11 and July 1-3, 2004) in the same suburban area of Toulouse conurbation, during the Intensive Observing Periods (IOP) of CAPITOUL. Concentration data were collected both at ground-level along axes perpendicular to the wind direction (at distances ranging between 280 m and 5000 m from the release point), and above the ground at 100 m and 200 m height using aircraft flights. Meteorological conditions were all associated with daytime anticyclonic conditions with weak winds and convective clear and cloudy boundary layers. A meso-scale dispersion modelling system, PERLE, developed at Meteo-France for environmental emergencies in case of atmospheric accidental release, was evaluated in terms of meteorology and dispersion, for the different tracer experiments, in its operational configuration. PERLE is based on the combination of the non-hydrostatic meso-scale MESO-NH model, running at 2 km horizontal resolution, and the Lagrangian particle model SPRAY. The statistical meteorological evaluation includes two sets of simulations with initialisation from ECMWF or ALADIN. The meteorological day-to-day error statistics show fairly good Meso-NH predictions, in terms of wind speed, wind direction and near-surface temperature. A strong sensitivity to initial fields concerns the surface fluxes, crucial for dispersion, with an excessive drying of the convective boundary layer with ALADIN initial fields, leading to an overprediction of surface sensible heat fluxes. A parameterization of dry and shallow convection according to the Eddy-Diffusivity-Mass-Flux (EDMF) approach (Pergaud et al. 2008) allows an efficient mixing in the Convective Boundary Layer (CBL) and improves significantly the wind fields. A statistical evaluation of the dispersion prediction was then performed and shows a

  1. Design and implementation of an anatomical web interface

    International Nuclear Information System (INIS)

    Barker, T.M.; Young, J.

    1996-01-01

    Full text: The Internet, and in particular, the World-Wide Web, has provided tremendous opportunities for enabling access and transfer of information. Traditionally, Internet services have relied on textual methods for delivery of information. The World-Wide Web (WWW) in its current (and ever-changing form) is primarily a method of communication which includes both graphical and textual information. The easy-to-use graphical interface, developed as part of the WWW, is based on the Hypertext Mark-up Language (HTML). More advanced interfaces can be developed by incorporating interactive documents, which can be updated depending upon the wishes of the user. The Common Gateway Interface (CGI) can be utilised to transfer information b y utilising various programming and scripting languages (eg. C, Perl). This paper describes the development of a WWW interface for the viewing of anatomical and radiographic information in the form of two-dimensional cross-sectional images and three-dimensional reconstruction images. HTML documents were prepared using a commercial software program (HotDog, Sausage Software Co., Australia). Forms were used to control user-selection parameters such as imaging modality and cross-sectional slice number. All documents were developed and tested using Netscape 2.0. Visual and radiographic images were processed using ANALYZE TM Version 7.5 (Biomedical Imaging Resource, Mayo Foundation, Rochester, USA). Perl scripting was used to process all requests passed to the WWW server. ANSI 'C' programming was used to implement image processing operations which are performed in response to user-selected options. The interface which has been developed is easy to use, is independent of browsing software, is accessible by multiple users, and provides an example of how easily medical imaging data can be distributed amongst interested parties. Various imaging datasets, including the Visible Human Project TM (National Library of Medicine, USA.) have been prepared

  2. Diagnosis of electrocution: The application of scanning electron microscope and energy-dispersive X-ray spectroscopy in five cases.

    Science.gov (United States)

    Visonà, S D; Chen, Y; Bernardi, P; Andrello, L; Osculati, A

    2018-03-01

    Deaths from electricity, generally, do not have specific findings at the autopsy. The diagnosis is commonly based on the circumstances of the death and the morphologic findings, above all the current mark. Yet, the skin injury due to an electrocution and other kinds of thermal injuries often cannot be differentiated with certainty. Therefore, there is a great interest in finding specific markers of electrocution. The search for the metallization of the skin through Scanning Electron Microscope equipped with Energy Dispersive X-Ray Spectroscopy (EDS) probe is of special importance in order to achieve a definite diagnosis in case of suspected electrocution. We selected five cases in which the electrocution was extremely likely considering the circumstances of the death. In each case a forensic autopsy was performed. Then, the skin specimens were stained with Hematoxylin Eosin and Perls. On the other hand, the skin lesions were examined with a scanning electron microscope equipped with EDS probe in order to evaluate the morphological ultrastructural features and the presence of deposits on the surface of the skin. The typical skin injury of the electrocution (current mark) were macroscopically detected in all of the cases. The microscopic examination of the skin lesions revealed the typical spherical vacuoles in the horny layer and, in the epidermis, the elongation of the cell nuclei as well as necrosis. Perls staining was negative in 4 out 6 cases. Ultrastructural morphology revealed the evident vacuolization of the horny layer, elongation of epidermic cells, coagulation of the elastic fibers. In the specimens collected from the site of contact with the conductor of case 1 and 2, the presence of the Kα peaks of iron was detected. In the corresponding specimens taken from cases 2, 4, 5 the microanalysis showed the Kα peaks of titanium. In case 3, titanium and carbon were found. In the suspicion of electrocution, the integrated use of different tools is recommended

  3. TF-finder: A software package for identifying transcription factors involved in biological processes using microarray data and existing knowledge base

    Directory of Open Access Journals (Sweden)

    Cui Xiaoqi

    2010-08-01

    many important TFs involved in salt and drought tolerance as evidenced by the rediscovery of those TFs that have been experimentally validated. The efficiency of TF-finder in recognizing novel TFs was further confirmed by a thorough comparison with a method called Intersection of Coexpression (ICE. Conclusions TF-finder can be successfully used to infer novel TFs involved a biological process of interest using publicly available gene expression data and known positive genes from existing knowledge bases. The package for TF-finder includes an R script for ASCCA, a Perl controller, and several Perl scripts for parsing intermediate outputs. The package is available upon request (hairong@mtu.edu. The R code for standalone ASCCA is also available.

  4. The Live Access Server Scientific Product Generation Through Workflow Orchestration

    Science.gov (United States)

    Hankin, S.; Calahan, J.; Li, J.; Manke, A.; O'Brien, K.; Schweitzer, R.

    2006-12-01

    The Live Access Server (LAS) is a well-established Web-application for display and analysis of geo-science data sets. The software, which can be downloaded and installed by anyone, gives data providers an easy way to establish services for their on-line data holdings, so their users can make plots; create and download data sub-sets; compare (difference) fields; and perform simple analyses. Now at version 7.0, LAS has been in operation since 1994. The current "Armstrong" release of LAS V7 consists of three components in a tiered architecture: user interface, workflow orchestration and Web Services. The LAS user interface (UI) communicates with the LAS Product Server via an XML protocol embedded in an HTTP "get" URL. Libraries (APIs) have been developed in Java, JavaScript and perl that can readily generate this URL. As a result of this flexibility it is common to find LAS user interfaces of radically different character, tailored to the nature of specific datasets or the mindset of specific users. When a request is received by the LAS Product Server (LPS -- the workflow orchestration component), business logic converts this request into a series of Web Service requests invoked via SOAP. These "back- end" Web services perform data access and generate products (visualizations, data subsets, analyses, etc.). LPS then packages these outputs into final products (typically HTML pages) via Jakarta Velocity templates for delivery to the end user. "Fine grained" data access is performed by back-end services that may utilize JDBC for data base access; the OPeNDAP "DAPPER" protocol; or (in principle) the OGC WFS protocol. Back-end visualization services are commonly legacy science applications wrapped in Java or Python (or perl) classes and deployed as Web Services accessible via SOAP. Ferret is the default visualization application used by LAS, though other applications such as Matlab, CDAT, and GrADS can also be used. Other back-end services may include generation of Google

  5. msBayes: Pipeline for testing comparative phylogeographic histories using hierarchical approximate Bayesian computation

    Directory of Open Access Journals (Sweden)

    Takebayashi Naoki

    2007-07-01

    Full Text Available Abstract Background Although testing for simultaneous divergence (vicariance across different population-pairs that span the same barrier to gene flow is of central importance to evolutionary biology, researchers often equate the gene tree and population/species tree thereby ignoring stochastic coalescent variance in their conclusions of temporal incongruence. In contrast to other available phylogeographic software packages, msBayes is the only one that analyses data from multiple species/population pairs under a hierarchical model. Results msBayes employs approximate Bayesian computation (ABC under a hierarchical coalescent model to test for simultaneous divergence (TSD in multiple co-distributed population-pairs. Simultaneous isolation is tested by estimating three hyper-parameters that characterize the degree of variability in divergence times across co-distributed population pairs while allowing for variation in various within population-pair demographic parameters (sub-parameters that can affect the coalescent. msBayes is a software package consisting of several C and R programs that are run with a Perl "front-end". Conclusion The method reasonably distinguishes simultaneous isolation from temporal incongruence in the divergence of co-distributed population pairs, even with sparse sampling of individuals. Because the estimate step is decoupled from the simulation step, one can rapidly evaluate different ABC acceptance/rejection conditions and the choice of summary statistics. Given the complex and idiosyncratic nature of testing multi-species biogeographic hypotheses, we envision msBayes as a powerful and flexible tool for tackling a wide array of difficult research questions that use population genetic data from multiple co-distributed species. The msBayes pipeline is available for download at http://msbayes.sourceforge.net/ under an open source license (GNU Public License. The msBayes pipeline is comprised of several C and R programs that

  6. Influencia de los tratamientos térmicos en el comportamiento frente al desgaste por abrasión de una fundición de grafito esferoidal obtenida mediante adición de boro

    Directory of Open Access Journals (Sweden)

    Varela, A.

    2008-08-01

    Full Text Available By adding boron to the liquid metal, it is possible to obtain spheroidal graphite cast iron without any need for special inoculants. The boron may be in metallic form; alternatively, borax, ferroboron, boron carbonate or borocalcium can be used. These alloys as cast present a pearlite matrix with more or less spheroidal graphite, which is usually edged in ferrite that has markings in the shape of bull’s eye. With normalising, the ferrite edges are eliminated. Thus, a pearlite matrix is achieved. Annealing results in an entirely ferrite matrix; quenching and tempering produce a tempered martensite matrix.This study measures the behaviour under wear of this alloy as cast, normalised, annealed, quenched and tempered . A “pin on disk” test is employed; load and speed conditions, as well as the pin type, are kept constant. Moreover, wear is calculated through weighing, and the variation for the friction coefficient is determined in each case.

    Mediante la adición de boro al metal líquido, bien en forma metálica o en forma de bórax, ferroboro, carburo de boro o boruro cálcico, se pueden obtener fundiciones de grafito esferoidal sin necesidad de inoculantes especiales. Estas fundiciones en estado bruto de colada presentan una matriz perlítica con grafito más o menos esferoidal que suele estar orlado de ferrita formando ojos de buey. Por tratamiento térmico de normalizado, se consigue eliminar la orla ferrítica y tener una matriz enteramente perlítica. Por recocido, se puede obtener una matriz enteramente ferrítica y por temple y revenido una matriz de martensita revenida. En el presente trabajo se mide el comportamiento frente al desgaste abrasivo de la aleación indicada, en estado bruto de colada, normalizado, recocido y bonificado, utilizando el ensayo pin on disk, manteniendo fijas las condiciones de ensayo en cuanto a carga, velocidad y tipo de pin, calculando el desgaste producido por pesada. También, se

  7. Influencia de la composición química de diferentes chatarras de acero sobre las propiedades mecánicas de la fundición con grafito esferoidal

    Directory of Open Access Journals (Sweden)

    Asenjo, I.

    2011-08-01

    producir piezas con estructuras perlíticas y/o ferrítico-perlíticas. En ningún caso se ha detectado la formación de carburos.

  8. Re-irradiation after gross total resection of recurrent glioblastoma. Spatial pattern of recurrence and a review of the literature as a basis for target volume definition

    Energy Technology Data Exchange (ETDEWEB)

    Straube, Christoph; Elpula, Greeshma [Technische Universitaet Muenchen (TUM), Department of Radiation Oncology, Klinikum rechts der Isar, Muenchen (Germany); Gempt, Jens; Gerhardt, Julia; Meyer, Bernhard [Technische Universitaet Muenchen (TUM), Department of Neurosurgery, Klinikum rechts der Isar, Muenchen (Germany); Bette, Stefanie; Zimmer, Claus [Technische Universitaet Muenchen (TUM), Department of Neuroradiology, Klinikum rechts der Isar, Muenchen (Germany); Schmidt-Graf, Friederike [Technische Universitaet Muenchen (TUM), Department of Neurology, Klinikum rechts der Isar, Muenchen (Germany); Combs, Stephanie E. [Technische Universitaet Muenchen (TUM), Department of Radiation Oncology, Klinikum rechts der Isar, Muenchen (Germany); Helmholtz Zentrum Muenchen, Institute for Innovative Radiotherapy (iRT), Department of Radiation Sciences (DRS), Oberschleissheim (Germany)

    2017-11-15

    Currently, patients with gross total resection (GTR) of recurrent glioblastoma (rGBM) undergo adjuvant chemotherapy or are followed up until progression. Re-irradiation, as one of the most effective treatments in macroscopic rGBM, is withheld in this situation, as uncertainties about the pattern of re-recurrence, the target volume, and also the efficacy of early re-irradiation after GTR exist. Imaging and clinical data from 26 consecutive patients with GTR of rGBM were analyzed. The spatial pattern of recurrences was analyzed according to the RANO-HGG criteria (''response assessment in neuro-oncology criteria for high-grade gliomas''). Progression-free (PFS) and overall survival (OS) were analyzed by the Kaplan-Meier method. Furthermore, a systematic review was performed in PubMed. All but 4 patients underwent adjuvant chemotherapy after GTR. Progression was diagnosed in 20 of 26 patients and 70% of recurrent tumors occurred adjacent to the resection cavity. The median extension beyond the edge of the resection cavity was 20 mm. Median PFS was 6 months; OS was 12.8 months. We propose a target volume containing the resection cavity and every contrast enhancing lesion as the gross tumor volume (GTV), a spherical margin of 5-10 mm to generate the clinical target volume (CTV), and a margin of 1-3 mm to generate the planning target volume (PTV). Re-irradiation of this volume is deemed to be safe and likely to prolong PFS. Re-irradiation is worth considering also after GTR, as the volumes that need to be treated are limited and re-irradiation has already proven to be a safe treatment option in general. The strategy of early re-irradiation is currently being tested within the GlioCave/NOA 17/Aro 2016/03 trial. (orig.) [German] Patienten mit einem rezidivierten Glioblastom (rGBM) werden, wenn eine komplette Resektion (GTR) des makroskopischen Rezidivs durchgefuehrt wurde, aktuell meist systemisch adjuvant behandelt oder einer engmaschigen Nachsorge

  9. Asbestos exposure during quarrying and processing of serpentinites: a case study in Valmalenco, Central Alps, Northern Italy

    Science.gov (United States)

    Cavallo, A.; Rimoldi, B.

    2012-04-01

    Serpentinites are metamorphic rocks derived from ultramafics such as peridotites (lherzolites and/or harzburgites), with a typical mineralogical assemblage of antigorite, olivine, diopside and minor magnetite, chlorite and chrysotile. If the rock mass has good geotechnical properties, these stones are quarried because of their wide variety of green shades and outstanding technical properties. Excellent stones are produced in the Malenco Valley, Central Alps (northern Italy, Sondrio): here the geological set-up is dominated by the ultramafic Malenco massif (lower crust-mantle complex), exposed at the Penninic to Austroalpine boundary zone. Different processing operations give origin to valuable products like stoves, funeral monuments, design home appliances; important building element as roof slabs, tiles for floor and wall coverings constitute the main commercial line of production. In this area, good quality long fibre chrysotile asbestos was mined since the XIX century, till the seventies. The asbestos fissures (mostly slip-fiber) are well known in Valmalenco, associated to an important ENE-WSW striking fracture and hydrothermal vein system. Some actual serpentinite quarries "cross" at times tunnels of the old asbestos mines, because the fracture and vein system "guides" the extraction. At present time, this area represents an excellent example of naturally occurring asbestos (NOA). For these reasons, workers' exposure to asbestos during quarrying and processing cannot be ruled out, and must be assessed according to national laws. From 2004 to nowadays, the INAIL Regional Management of Lombardia, with the collaboration of University of Milan-Bicocca, carried out extensive monitoring campaigns both in quarries and in processing laboratories. More than 300 massive samples (rocks and veins) and 250 airborne dust samples were collected during the surveys. One of the main problems in the study of massive serpentinites is the accurate identification of the different

  10. Regional drought in the southern of South America: physical aspects Seca regional no sul da América do Sul: aspectos físicos

    Directory of Open Access Journals (Sweden)

    Juan Leonidas Minetti

    2010-03-01

    Full Text Available From the indices of monthly and annual climatic drought in six regions in southern South America and their associations with seventeen predictors, the probable physical causes of droughts are analyzed. These indices are used in operational climate monitoring and describe the atmospheric temperature and sea surface temperature (SST near South America. Subtropical anticyclone activity over both coasts of South America is one of the main predictors, together with its interaction with the continental depression and SST at the coast of Brazil. The highest predictability concentrates in November-December-May and the lowest in March, June and August. In the sub regional scale, the main predictors respond to atmospheric pressure anomalies in the Atlantic Ocean for Argentinean Northwest (NOA, SST in the Brazilian coast for Argentinean Northeast (NEA, anticyclonic conditions over the Pacific and Atlantic for the Central West (CO, the latter and their interaction with the continental depression for Humid Pampa (PH, anticyclonic activity over the Pacific for the Patagonia (PAT and trans cordillera circulation for Central Chile and Comahue (CHI.As causas físicas prováveis das secas em seis regiões no sul da América do Sul são analisadas, através de índices da seca climática mensal e em suas associações com dezessete preditores. Esses indices são usados no monitoramento operacional do clima, e descrevem a temperatura atmosférica e a temperatura de superfície do mar (TSM perto de América do Sul. A atividade do anticiclone subtropical sobre ambas as costas de América do Sul é um dos preditores principais, junto com sua interação com a depressão continental e a SST na costa do Brasil. A previsibilidade mais elevada concentra-se nos meses Novembro-Dezembro-Maio e a mais baixa, em março, junho e agosto. Na escala regional secundária, os principais preditores respondem às anomalias da pressão atmosférica sobre o Oceano Atlântico para

  11. Análisis del comportamiento de cultivares comerciales de soja en el noroeste argentino Analysis of the behaviour of soybean commercial varieties in northwestern Argentina

    Directory of Open Access Journals (Sweden)

    José R. Sánchez

    Full Text Available Para alcanzar el máximo potencial de rendimiento en soja (Glycine max L. en el noroeste argentino (NOA, se debe utilizar el mejor paquete tecnológico disponible, siendo los materiales genéticos elementos fundamentales. Por ello, es de suma importancia conocer el comportamiento de las diferentes variedades en la región. Los datos de la Red de Evaluación de Variedades Comerciales de Soja del NOA fueron utilizados para evaluar el impacto del ambiente en el rendimiento de diferentes variedades. El análisis determinó primero la conducta de los cultivares en ambientes previamente clasificados como favorables y desfavorables, según su rendimiento medio. Se observó que los cultivares A 6401 RG, A 8100 RG y Munasqa RR, entre otros, rindieron por encima de la media sólo en ambientes desfavorables, mientras que A 7636 RG superó a la media solamente en ambientes favorables. El estudio también reveló variedades con altos rendimientos en ambos ambientes (A 8000 RG, AW 7110 RR, DM 6200 RR, entre otras y cultivares cuyo rendimiento en ningún caso fue superior a la media. El análisis también permitió clasificar los cultivares según su grado de estabilidad o adaptación a diferentes situaciones de cultivo. Se identificó a los materiales Munasqa RR, A 8100 RG, A 6401 RG y A 4910 RG como estables, con rendimientos mayores a la media en ambientes desfavorables. Los cultivares A 8000 RG y A 7636 RG fueron categorizados como adaptables (destacándose especialmente el primero de ellos, ya que sus rendimientos fueron buenos o aceptables en todas las situaciones estudiadas.In order to achieve soybean (Glycine max L. maximum reachable yield levels in northwestern Argentina, it is crucial to use the most advanced technology. Genetics plays a fundamental role, so it is highly important to study the behaviour of different soybean varieties available in the region. Six-season data from "Red de Evaluación de Variedades Comerciales de Soja del Noroeste

  12. Plastic solar collector: feature and applications; Colector solar de plastico: Caracteristicas y aplicaciones

    Energy Technology Data Exchange (ETDEWEB)

    Bistoni, Silvia; Iriarte, Adolfo [Universidad Nacional de Catamarca, Catamarca (Argentina); Saravia, Luis [Universidad Nacional de Salta, Salta (Argentina)

    2000-07-01

    The Argentinean northwest (NOA) is an exceptional zone to use solar energy, because of its climate and its solar radiation levels. The aim of this paper is to analyze the use of low temperature solar heating system by mean of a plastic collector. The system proposed includes: a) Solar collectors built with plastic bags, welded in such a way that water, introduced at the top, falls by gravity through a zigzag long path. Each collector is fed by drip feed irrigations. b) Hot water storage and c) Water pump, hydraulic circuit and electronic controls. Two ways of use are proposed: as a water solar heating and as a system to heat greenhouses. In this second case, if during the day the air temperature inside the greenhouse is higher than the water storage temperature, the water will be heated in the bags. During the night the bags work as heat exchanger. When the temperature inside the greenhouse needs to be maintained at a constant value, the heating system is combined with a gas water heating. The equipment is described, performances are compared for both uses and the global heat exchange coefficient is calculated. The system's behavior inside a greenhouse is analyzed in two different situations. The utilization of plastic solar collectors has demonstrate to be a valid alternative for low temperature solar energy uses, specially in heating agricultural spaces. [Spanish] La region del Noreste Argentino (NOA), por su clima y muy en particular por los niveles de radiacion solar que posee, es una zona excepcional para el aprovechamiento de la energia solar. El objetivo de este trabajo es analizar el uso de la energia solar a baja temperatura mediante un colector de plastico. El sistema propuesto incluye: a) Colector solar construido con una bolsa de plastico soldada en forma tal, que el agua que se introduce por la parte superior cae por la gravedad siguiendo un camino en zigzag. Cada colector se alimenta mediante goteros de riego autocompensados. b) Almacenamiento

  13. Tailored stakeholder products help provide a vulnerability and adaptation assessment of Greek forests due to climate change

    Science.gov (United States)

    Giannakopoulos, Christos; Karali, Anna; Roussos, Anargyros

    2014-05-01

    Greece, being part of the eastern Mediterranean basin, is an area particularly vulnerable to climate change and associated forest fire risk. The aim of this study is to assess the vulnerability of Greek forests to fire risk occurrence and identify potential adaptation options within the context of climate change through continuous interaction with local stakeholders. To address their needs, the following tools for the provision of climate information services were developed: 1. An application providing fire risk forecasts for the following 3 days (http://cirrus.meteo.noa.gr/forecast/bolam/index.htm) was developed from NOA to address the needs of short term fire planners. 2. A web-based application providing long term fire risk and other fire related indices changes due to climate change (time horizon up to 2050 and 2100) was developed in collaboration with the WWF Greece office to address the needs of long term fire policy makers (http://www.oikoskopio.gr/map/). 3. An educational tool was built in order to complement the two web-based tools and to further expand knowledge in fire risk modeling to address the needs for in-depth training. In particular, the second product provided the necessary information to assess the exposure to forest fires. To this aim, maps depicting the days with elevated fire risk (FWI>30) both for the control (1961-1990) and the near future period (2021-2050) were created by the web-application. FWI is a daily index that provides numerical ratings of relative fire potential based solely on weather observations. The meteorological inputs to the FWI System are daily noon values of temperature, air relative humidity, 10m wind speed and precipitation during the previous 24 hours. It was found that eastern lowlands are more exposed to fire risk followed by eastern high elevation areas, for both the control and near future period. The next step towards vulnerability assessment was to address sensitivity, ie the human-environmental conditions that

  14. Consumo de sustancias psicoactivas en dos regiones argentinas y su relación con indicadores de pobreza Consumo de substâncias psicoativas em duas regiões argentinas e sua relação com indicadores de pobreza Psychoactive substance use in two regions of Argentina and its relationship to poverty

    Directory of Open Access Journals (Sweden)

    Carla Ap. Arena Ventura

    2013-05-01

    Full Text Available Se realizó un análisis de base de datos recolectados en la Encuesta Nacional de Prevalencia de Consumo de Sustancias Psicoactivas (ENPreCoSP-2.008 tomando 6.122 casos, con los objetivos de describir las prevalencias de consumo de sustancias psicoactivas; y evaluar la asociación entre la existencia de necesidades básicas insatisfechas y el nivel de ingresos familiares, con el consumo de sustancias psicoactivas en personas entre las edades de 18 a 34 años, residentes en las regiones noroeste (NOA y noreste (NEA argentino. Se realizaron análisis descriptivos y regresión logística. Las prevalencias de consumo en la vida, el último año y el último mes fueron mayores en sustancias legales. Así también, el consumo fue mayor en el sexo masculino. Los indicadores de situación de pobreza operaron como factor de riesgo para el consumo de sustancias legales. Los resultados encontrados dan cuenta de situaciones diferenciales en el consumo de sustancias psicoactivas, en relación al género y a las condiciones de pobreza.Realizou-se uma análise de base de dados coletados durante a Encuesta Nacional de Prevalencia de Consumo de Sustancias Psicoactivas (ENPreCoSP-2.008 tomando 6.122 casos, com objetivos de descrever as prevalências de consumo de substâncias psicoactivas, e avaliar a associação entre a existência de necessidades básicas insatisfeitas e o nível de renda familiar, com o consumo de substâncias psicoactivas em pessoas de 18 a 34 anos, residentes nas regiões noroeste (NOA e nordeste (NEA da Argentina. Realizaram-se análises descritivas e regressão logística. As prevalências de consumo durante a vida, o último ano e o último mês foram maiores entre as substâncias legais. O consumo também foi maior no sexo masculino. Os indicadores da situação de pobreza operaram como fator de risco para o consumo de substâncias legais. Os resultados encontrados mostram situações diferenciais no consumo de substâncias psicoativas

  15. Characterization of the sources and processes of organic and inorganic aerosols in New York city with a high-resolution time-of-flight aerosol mass apectrometer

    Directory of Open Access Journals (Sweden)

    Y.-L. Sun

    2011-02-01

    Full Text Available Submicron aerosol particles (PM1 were measured in-situ using a High-Resolution Time-of-Flight Aerosol Mass Spectrometer during the summer 2009 Field Intensive Study at Queens College in New York, NY. Organic aerosol (OA and sulfate are the two dominant species, accounting for 54% and 24%, respectively, of the total PM1 mass. The average mass-based size distribution of OA presents a small mode peaking at ~150 nm (Dva and an accumulation mode (~550 nm that is internally mixed with sulfate, nitrate, and ammonium. The diurnal cycles of both sulfate and OA peak between 01:00–02:00 p.m. EST due to photochemical production. The average (±σ oxygen-to-carbon (O/C, hydrogen-to-carbon (H/C, and nitrogen-to-carbon (N/C ratios of OA in NYC are 0.36 (±0.09, 1.49 (±0.08, and 0.012 (±0.005, respectively, corresponding to an average organic mass-to-carbon (OM/OC ratio of 1.62 (±0.11. Positive matrix factorization (PMF of the high resolution mass spectra identified two primary OA (POA sources, traffic and cooking, and three secondary OA (SOA components including a highly oxidized, regional low-volatility oxygenated OA (LV-OOA; O/C = 0.63, a less oxidized, semi-volatile SV-OOA (O/C = 0.38 and a unique nitrogen-enriched OA (NOA; N/C = 0.053 characterized with prominent CxH2x + 2N+ peaks likely from amino compounds. Our results indicate that cooking and traffic are two distinct and mass-equivalent POA sources in NYC, together contributing ~30% of the total OA mass during this study. The OA composition is dominated by secondary species, especially during high PM events. SV-OOA and LV-OOA on average account for 34% and 30%, respectively, of the total OA mass. The chemical evolution of SOA in NYC appears to progress with a continuous oxidation from SV-OOA to LV-OOA, which is further supported by a gradual increase of O/C ratio and a simultaneous decrease of H/C ratio in total OOA. Detailed

  16. The international normalized ratio (INR as seen in a population of patients with atrial fibrillation and cerebral infarction undergoing long-term treatment with vitamin K antagonists

    Directory of Open Access Journals (Sweden)

    Szczepańska-Szerej Anna

    2015-12-01

    Full Text Available It is estimated that nearly 20% of all cerebral infarctions in the total population are the result of a complication of atrial fibrillation (AF. While oral anticoagulation with vitamin K antagonists (AVKs substantially reduces this risk, this requires regular monitoring of the international normalized ratio (INR in order to achieve therapeutic levels (2,0-3,0. The aim of this study was to evaluate a group at high risk of cerebral infarction, among patients with AF undergoing long-term treatment with VKAs, taking into account the significance of therapeutic INR values. The analysed group consisted of 90 acute ischaemic stroke patients with paroxysmal or chronic “non-valvular” AF, receiving treatment with VKAs. As a result of the study, therapeutic INR values (≥ 2 were seen in thirty-five of these individuals (38,8%, while 55 (61,2% showed non-therapeutic INR values. Moreover, there were no differences in demographics, vascular risk factors, biochemical and morphological blood parameters, mean CHA2DS2-VASc score and TOAST classification between either of the two groups. Furthermore, no additional factor that would increase their risk of cerebral infarction during the adequate treatment with VKAs was found. However, patients with non-therapeutic INR values had a statistically significantly higher frequency of concomitant moderate pathology of the bicuspid valve, p<0.05. Hence, a lack of proper control of INR can proved to be particularly dangerous for this subgroup of patients. Hence, this is a group with an elevated risk of cerebral infarction and therefore requires special oversight of VKA treatment or NOA treatment.

  17. Microvoid channel polymer photonic crystals with large infrared stop gaps and a multitude of higher-order bandgaps fabricated by femtosecond laser drilling in solid resin

    International Nuclear Information System (INIS)

    Straub, M.; Ventura, M.; Gu, M.

    2004-01-01

    Photosensitive polymer materials are ideally suited for laser-induced micro- and nanostructuring, as structural and compositional changes are achieved already under exposure to moderate intensities of high-repetition rate ultrashort-pulsed light. Photonic crystals with bandgaps in the infrared or the visible spectral region are a particularly interesting application, because highly correlated structural elements at a size of only a few hundred nanometers are required. We fabricated infrared photonic crystals based on microvoid channels inside solid polymer material. Femtosecond-pulsed visible light was focused into UV-cured Norland NOA63 resin by a high numerical aperture objective. In the focal spot microexplosions drive the material out of the center of the focus. Void channels of 0.7-1.3 μm diameter are generated by translating the sample along a preprogrammed pathway. Woodpile structures of void channels at layer spacings of 1.6-2.6 μm and in-plane channel spacings of 1.2-1.3 μm allowed for bandgap-induced suppression of infrared transmission in the stacking direction of as much as 86% by only 20 layers. As these structures are highly correlated and do not contain many imperfections, up to three higher-order stop gaps are observed. Consistent with theory, the number and gapwidth of higher-order gaps strongly increases with the ratio between layer- and in-plane spacing. Due to their low refractive index contrast and the missing interconnectivity of voids our structures do not provide complete photonic bandgaps. However, their manifold of sizable higher-order gaps allows for the engineering of photonic stop gaps down to the near-infrared wavelength region using comparatively large structural dimensions

  18. In vitro propagation, encapsulation, and genetic fidelity analysis of Terminalia arjuna: a cardioprotective medicinal tree.

    Science.gov (United States)

    Gupta, Amit K; Harish; Rai, Manoj K; Phulwaria, Mahendra; Agarwal, Tanvi; Shekhawat, N S

    2014-07-01

    The present study described an improved and reproducible in vitro regeneration system for Terminalia arjuna using nodal segment explants obtained from a mature plant. Shoot tips excised from in vitro proliferated shoots were encapsulated in 3 % sodium alginate and 100 mM CaCl2[Symbol: see text]2H2O for the development of synthetic seeds which may be applicable in short-term storage and germplasm exchange of elite genotype. Shoot multiplication was significantly influenced by a number of factors, namely types and concentrations of plant growth regulators, medium composition, repeated transfer of mother explants, subculturing of in vitro regenerated shoot clumps, agar concentrations, and temperature. Maximum numbers of shoots (16.50 ± 3.67) were observed on modified Murashige and Skoog (MMS) medium containing 0.5 mg l(-1) of benzylaminopurine (BAP) and 0.1 mg l(-1) of naphthalene acetic acid (NAA). To shortening the regeneration pathway, rooting of micropropagated shoots under in vitro condition was excluded and an experiment on ex vitro rooting was conducted and it was observed that the highest percentage of shoots rooted ex vitro when treated with indole-3-butyric acid (IBA, 250 mg l(-1)) + 2-naphthoxy acetic acid (NOA, 250 mg l(-1)) for 5 min. The well-developed ex vitro rooted shoots were acclimatized successfully in soilrite under greenhouse conditions with 80 % survival of plants. Randomly amplified polymorphic DNA (RAPD) analysis confirmed that all the regenerated plants were genetically identical to the mother plant, suggesting the absence of detectable genetic variation in the regenerated plantlets. To the best of our knowledge, this is the first report on synthetic seed production as well as ex vitro rooting and genetic fidelity assessment of micropropagated shoots of T. arjuna.

  19. Survey of intravitreal injection techniques among retina specialists in Israel

    Directory of Open Access Journals (Sweden)

    Segal O

    2016-06-01

    Full Text Available Ori Segal,1,2 Yael Segal-Trivitz,1,3 Arie Y Nemet,1,2 Noa Geffen,1,2 Ronit Nesher,1,2 Michael Mimouni4 1Department of Ophthalmology, Meir Medical Center, Kfar Saba, 2The Sackler School of Medicine, Tel Aviv University, Tel Aviv, 3Department of Psychiatry, Geha Psychiatric Hospital, Petah Tikva, 4Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel Purpose: The purpose of this study was to describe antivascular endothelial growth factor intravitreal injection techniques of retinal specialists in order to establish a cornerstone for future practice guidelines. Methods: All members of the Israeli Retina Society were contacted by email to complete an anonymous, 19-question, Internet-based survey regarding their intravitreal injection techniques. Results: Overall, 66% (52/79 completed the survey. Most (98% do not instruct patients to discontinue anticoagulant therapy and 92% prescribe treatment for patients in the waiting room. Three quarters wear sterile gloves and prepare the patient in the supine position. A majority (71% use sterile surgical draping. All respondents apply topical analgesics and a majority (69% measure the distance from the limbus to the injection site. A minority (21% displace the conjunctiva prior to injection. A majority of the survey participants use a 30-gauge needle and the most common quadrant for injection is superotemporal (33%. Less than half routinely assess postinjection optic nerve perfusion (44%. A majority (92% apply prophylactic antibiotics immediately after the injection. Conclusion: The majority of retina specialists perform intravitreal injections similarly. However, a relatively large minority performs this procedure differently. Due to the extremely low percentage of complications, it seems as though such differences do not increase the risk. However, more evidence-based medicine, a cornerstone for practice guidelines, is required in order to identify the intravitreal injection techniques

  20. Chemical characterization of long-range transport biomass burning emissions to the Himalayas: insights from high-resolution aerosol mass spectrometry

    Science.gov (United States)

    Zhang, Xinghua; Xu, Jianzhong; Kang, Shichang; Liu, Yanmei; Zhang, Qi

    2018-04-01

    An intensive field measurement was conducted at a remote, background, high-altitude site (Qomolangma Station, QOMS, 4276 m a.s.l.) in the northern Himalayas, using an Aerodyne high-resolution time-of-flight aerosol mass spectrometer (HR-ToF-AMS) along with other collocated instruments. The field measurement was performed from 12 April to 12 May 2016 to chemically characterize the high time-resolved submicron particulate matter (PM1) and obtain the dynamic processes (emissions, transport, and chemical evolution) of biomass burning (BB), frequently transported from South Asia to the Himalayas during pre-monsoon season. Overall, the average (±1σ) PM1 mass concentration was 4.44 (±4.54) µg m-3 for the entire study, which is comparable with those observed at other remote sites worldwide. Organic aerosol (OA) was the dominant PM1 species (accounting for 54.3 % of total PM1 on average) followed by black carbon (BC) (25.0 %), sulfate (9.3 %), ammonium (5.8 %), nitrate (5.1 %), and chloride (0.4 %). The average size distributions of PM1 species all peaked at an overlapping accumulation mode (˜ 500 nm), suggesting that aerosol particles were internally well-mixed and aged during long-range transport. Positive matrix factorization (PMF) analysis on the high-resolution organic mass spectra identified three distinct OA factors, including a BB-related OA (BBOA, 43.7 %), a nitrogen-containing OA (NOA, 13.9 %) and a more-oxidized oxygenated OA (MO-OOA, 42.4 %). Two polluted episodes with enhanced PM1 mass loadings and elevated BBOA contributions from the west and southwest of QOMS during the study were observed. A typical BB plume was investigated in detail to illustrate the chemical evolution of aerosol characteristics under distinct air mass origins, meteorological conditions, and atmospheric oxidation processes.

  1. Strategic positioning of the ERATOSTHENES Research Centre for atmospheric remote sensing research in the Eastern Mediterranean and Middle East region

    Science.gov (United States)

    Mamouri, Rodanthi-Elisavet; Ansmann, Albert; Hadjimitsis, Diofantos G.; Nisantzi, Argyro; Bühl, Johannes; Michaelides, Silas; Seifert, Patric; Engelmann, Ronny; Wandinger, Ulla; Kontoes, Charalampos; Schreier, Gunter; Komodromos, Georgios; Themistocleous, Kyriacos

    2017-10-01

    The aim of this article is to present the importance of a permanent state-of-the-art atmospheric remote sensing ground based station in the region of the Eastern Mediterranean and Middle East (EMME). The ERATOSTHENES Research Centre (ERC) with the vision to become a Centre of Excellence for Earth Surveillance and Space-Based Monitoring of the Environment (EXCELSIOR H2020: Teaming project) already operates (within Phase 1) a fully established EARLINETt-Cloudnet supersite at Limassol, Cyprus, for a period of 2 years, in close collaboration with the German Leibniz Institute for Tropospheric Research (TROPOS), The scientific aspects of this prototype-like field campaign CyCARE (Cyprus Cloud Aerosol and Rain Experiment) - a common initiative between the Cyprus University of Technology (CUT), Limassol and TROPOS- are presented in this paper. Cy-CARE has been designed by TROPOS and CUT to fill a gap in the understanding of aerosol-cloud interaction in one of the key regions of climate change and how precipitation formation is influenced by varying aerosol/pollution and meteorological conditions The guiding questions are: How may rain patterns change in future and what may be the consequences of climate change in arid regions such as EMME. EXCELSIOR is a team effort between CUT (acting as the coordinator), the German Aerospace Centre (DLR), the Institute for Astronomy and Astrophysics Space Applications and Remote Sensing of the National Observatory of Athens (NOA), TROPOS and the Cyprus Department of Electronic Communications of the Ministry of Transport, Communications and Works (DEC-MTCW) who will work together to improve the network structures significantly, resulting in Cyprus being regarded as a cornerstone of a European Network of active remote sensing of the atmosphere.

  2. Real-time appraisal of the spatially distributed heat related health risk and energy demand of cities

    Science.gov (United States)

    Keramitsoglou, Iphigenia; Kiranoudis, Chris T.; Sismanidis, Panagiotis

    2016-08-01

    The Urban Heat Island (UHI) is an adverse environmental effect of urbanization that increases the energy demand of cities, impacts the human health, and intensifies and prolongs heatwave events. To facilitate the study of UHIs the Institute for Astronomy, Astrophysics, Space Applications and Remote Sensing of the National Observatory of Athens (IAASARS/NOA) has developed an operational real-time system that exploits remote sensing image data from Meteosat Second Generation - Spinning Enhanced Visible and Infrared Imager (MSG-SEVIRI) and generates high spatiotemporal land surface temperature (LST) and 2 m air temperature (TA) time series. These datasets form the basis for the generation of higher value products and services related to energy demand and heat-related health issues. These products are the heatwave hazard (HZ); the HUMIDEX (i.e. an index that describes the temperature felt by an individual exposed to heat and humidity); and the cooling degrees (CD; i.e. a measure that reflects the energy needed to cool a building). The spatiotemporal characteristics of HZ, HUMIDEX and CD are unique (1 km/5 min) and enable the appraisal of the spatially distributed heat related health risk and energy demand of cities. In this paper, the real time generation of the high spatiotemporal HZ, HUMIDEX and CD products is discussed. In addition, a case study corresponding to Athens' September 2015 heatwave is presented so as to demonstrate their capabilities. The overall aim of the system is to provide high quality data to several different end users, such as health responders, and energy suppliers. The urban thermal monitoring web service is available at http://snf-652558.vm.okeanos.grnet.gr/treasure/portal/info.html.

  3. Improvement in mechanical properties of hypereutectic Al-Si-Cu alloys through sono-solidiifed slurry

    Institute of Scientific and Technical Information of China (English)

    Yoshiki Tsunekawa; Shinpei Suetsugu; Masahiro Okumiya; Naoki Nishikawa; Yoshikazu Genma

    2014-01-01

    For the wider applications, it is necessary to improve the ductility as wel as the strength and wear-resistance of hypereutectic Al-Si-Cu aloys, which are typical light-weight wear-resistant materials. An increase in the amounts of primary silicon particles causes the modiifed wear-resistance of hypereutectic Al-Si-Cu aloys, but leads to the poor strength and ductility. It is known that dual phase steels composed of hetero-structure have succeeded in bringing contradictory mechanical properties of high strength and ductility concurrently. In order to apply the idea of hetero-structure to hypereutectic Al-Si-Cu alloys for the achievement of high strength and ductility along with wear resistance, ultrasonic irradiation of the molten metal during the solidiifcation, which is caled sono-solidiifcation, was carried out from its molten state to just above the eutectic temperature. The sono-solidiifed Al-17Si-4Cu aloy is composed of hetero-structure, which are, hard primary silicon particles, soft non-equilibriuma-Al phase and the eutectic region. Rheo-casting was performed at just above the eutectic temperature with sono-solidiifed slurry to shape a disk specimen. After the rheo-casting with modiifed sono-solidiifed slurry held for 45 s at 570 ºC, the quantitative optical microscope observation exhibits that the microstructure is composed of 18area% of hard primary silicon particles and 57area% of softa-Al phase. In contrast, there exist only 5 area% of primary silicon particles and noa-Al phase in rheo-cast specimen with normaly solidiifed slurry. Hence the tensile tests of T6 treated rheo-cast specimens with modified sono-solidified slurry exhibit improved strength and 5% of elongation, regardless of having more than 3 times higher amounts of primary silicon particles compared to that of rheo-cast specimen with normaly solidiifed slurry.

  4. The Interaction between Auxin and Nitric Oxide Regulates Root Growth in Response to Iron Deficiency in Rice

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    Huwei Sun

    2017-12-01

    Full Text Available Fe deficiency (-Fe is a common abiotic stress that affects the root development of plants. Auxin and nitric oxide (NO are key regulator of root growth under -Fe. However, the interactions between auxin and NO regulate root growth in response to Fe deficiency are complex and unclear. In this study, the indole-3-acetic acid (IAA and NO levels in roots, and the responses of root growth in rice to different levels of Fe supply were investigated using wild type (WT, ospin1b and osnia2 mutants. -Fe promoted LR formation but inhibited seminal root elongation. IAA levels, [3H] IAA transport, and expression levels of PIN1a-c genes in roots were reduced under -Fe, suggesting that polar auxin transport from shoots to roots was decreased. Application of IAA to -Fe seedlings restored seminal root length, but not LR density, to levels similar to those under normal Fe (+Fe, and the seminal root length was shorter in two ospin1b mutants relative to WT under +Fe, but not under -Fe, confirming that auxin transport participates in -Fe-inhibited seminal root elongation. Moreover, -Fe-induced LR density and -Fe-inhibited seminal root elongation paralleled NO production in roots. Interestingly, similar NO accumulation and responses of LR density and root elongation were observed in osnia2 mutants compared to WT, and the higher expression of NOA gene under -Fe, suggesting that -Fe-induced NO was generated via the NO synthase-like pathway rather than the nitrate reductase pathway. However, IAA could restore the functions of NO in inhibiting seminal root elongation, but did not replace the role of NO-induced LR formation under -Fe. Overall, our findings suggested that NO functions downstream of auxin in regulating LR formation; NO-inhibited seminal root elongation by decreasing meristem activity in root tips under -Fe, with the involvement of auxin.

  5. Comparación del Nivel de Ingreso del Jefe de Hogar entre Aglomerados

    Directory of Open Access Journals (Sweden)

    María C. Leguizamón

    2006-05-01

    Full Text Available El análisis multiniveles surgió en las áreas de la educación, la sociología y la demografía; siendo aplicable a diversas situaciones en las que unidades de nivel inferior, o "microunidades", se imbrican en otras de nivel superior, o "macrounidades". En estudios económicos este análisis se conoce como Análisis de Datos en Panel. A través de esta metodología se puede estudiar el efecto simultáneo de variables individuales y grupales, y sus respectivas interacciones, sobre una variable dependiente a nivel individual. Los modelos multinivel son un caso particular de los Modelos Lineales generalizados, y se pueden aplicar a otros sistemas de análisis, como por ejemplo: al análisis de medidas repetidas, de datos categóricos, a los modelos de ecuaciones estructurales, a los procesos de series temporales, y a la regresión no-lineal. En este trabajo el objetivo propuesto es aplicar la metodología del análisis multinivel a un conjunto de datos provenientes de la Encuesta Permanente de Hogares (EPH. Comparar el nivel de ingreso de los jefes de hogar entre aglomerados de acuerdo a las características de los mismos y de los hogares considerados en la muestra. Los datos analizados surgen de los aglomerados urbanos del Gran Tucumán-Tafí Viejo y del resto del Noroeste Argentino (NOA1, relevados de la EPH continua del primer trimestre de 2005. Se considera como niveles MACRO a los Aglomerados y Hogares y como nivel MICRO a los Jefes de hogar.

  6. Personalized care in neuro-oncology coming of age: why we need MGMT and 1p/19q testing for malignant glioma patients in clinical practice

    Science.gov (United States)

    Weller, Michael; Stupp, Roger; Hegi, Monika E.; van den Bent, Martin; Tonn, Joerg C.; Sanson, Marc; Wick, Wolfgang; Reifenberger, Guido

    2012-01-01

    Histological subtyping and grading by malignancy are the cornerstones of the World Health Organization (WHO) classification of tumors of the central nervous system. They shall provide clinicians with guidance as to the course of disease to be expected and the choices of treatment to be made. Nonetheless, patients with histologically identical tumors may have very different outcomes, notably in patients with astrocytic and oligodendroglial gliomas of WHO grades II and III. In gliomas of adulthood, 3 molecular markers have undergone extensive studies in recent years: 1p/19q chromosomal codeletion, O6-methylguanine methyltransferase (MGMT) promoter methylation, and mutations of isocitrate dehydrogenase (IDH) 1 and 2. However, the assessment of these molecular markers has so far not been implemented in clinical routine because of the lack of therapeutic implications. In fact, these markers were considered to be prognostic irrespective of whether patients were receiving radiotherapy (RT), chemotherapy, or both (1p/19q, IDH1/2), or of limited value because testing is too complex and no chemotherapy alternative to temozolomide was available (MGMT). In 2012, this situation has changed: long-term follow-up of the Radiation Therapy Oncology Group 9402 and European Organisation for Research and Treatment of Cancer 26951 trials demonstrated an overall survival benefit from the addition to RT of chemotherapy with procarbazine/CCNU/vincristine confined to patients with anaplastic oligodendroglial tumors with (vs without) 1p/19q codeletion. Furthermore, in elderly glioblastoma patients, the NOA-08 and the Nordic trial of RT alone versus temozolomide alone demonstrated a profound impact of MGMT promoter methylation on outcome by therapy and thus established MGMT as a predictive biomarker in this patient population. These recent results call for the routine implementation of 1p/19q and MGMT testing at least in subpopulations of malignant glioma patients and represent an encouraging

  7. Use of "Crowd-Sourcing" and other collaborations to solve the short-term, earthquake forecasting problem

    Science.gov (United States)

    Bleier, T.; Heraud, J. A.; Dunson, J. C.

    2015-12-01

    QuakeFinder (QF) and its international collaborators have installed and currently maintain 165 three-axis induction magnetometer instrument sites in California, Peru, Taiwan, Greece, Chile and Sumatra. The data from these instruments are being analyzed for pre-quake signatures. This analysis consists of both private research by QuakeFinder, and institutional collaborators (PUCP in Peru, NCU in Taiwan, PUCC in Chile, NOA in Greece, Syiah Kuala University in Indonesia, LASP at U of Colo., Stanford, and USGS). Recently, NASA Hq and QuakeFinder tried a new approach to help with the analysis of this huge (50+TB) data archive. A collaboration with Apirio/TopCoder, Harvard University, Amazon, QuakeFinder, and NASA Hq. resulted in an open algorithm development contest called "Quest for Quakes" in which contestants (freelance algorithm developers) attempted to identify quakes from a subset of the QuakeFinder data (3TB). The contest included a $25K prize pool, and contained 100 cases where earthquakes (and null sets) included data from up to 5 remote sites, near and far from quakes greater than M4. These data sets were made available through Amazon.com to hundreds of contestants over a two week contest period. In a more traditional approach, several new algorithms were tried by actively sharing the QF data with universities over a longer period. These algorithms included Principal Component Analysis-PCA and deep neural networks in an effort to automatically identify earthquake signals within typical, noise-filled environments. This presentation examines the pros and cons of employing these two approaches, from both logistical and scientific perspectives.

  8. Imaging Biomarkers for Adult Medulloblastomas: Genetic Entities May Be Identified by Their MR Imaging Radiophenotype.

    Science.gov (United States)

    Keil, V C; Warmuth-Metz, M; Reh, C; Enkirch, S J; Reinert, C; Beier, D; Jones, D T W; Pietsch, T; Schild, H H; Hattingen, E; Hau, P

    2017-10-01

    The occurrence of medulloblastomas in adults is rare; nevertheless, these tumors can be subdivided into genetic and histologic entities each having distinct prognoses. This study aimed to identify MR imaging biomarkers to classify these entities and to uncover differences in MR imaging biomarkers identified in pediatric medulloblastomas. Eligible preoperative MRIs from 28 patients (11 women; 22-53 years of age) of the Multicenter Pilot-study for the Therapy of Medulloblastoma of Adults (NOA-7) cohort were assessed by 3 experienced neuroradiologists. Lesions and perifocal edema were volumetrized and multiparametrically evaluated for classic morphologic characteristics, location, hydrocephalus, and Chang criteria. To identify MR imaging biomarkers, we correlated genetic entities sonic hedgehog ( SHH ) TP53 wild type, wingless ( WNT ), and non -WNT/ non -SHH medulloblastomas (in adults, Group 4), and histologic entities were correlated with the imaging criteria. These MR imaging biomarkers were compared with corresponding data from a pediatric study. There were 19 SHH TP53 wild type (69%), 4 WNT -activated (14%), and 5 Group 4 (17%) medulloblastomas. Six potential MR imaging biomarkers were identified, 3 of which, hydrocephalus ( P = .03), intraventricular macrometastases ( P = .02), and hemorrhage ( P = .04), when combined, could identify WNT medulloblastoma with 100% sensitivity and 88.3% specificity (95% CI, 39.8%-100.0% and 62.6%-95.3%). WNT -activated nuclear β-catenin accumulating medulloblastomas were smaller than the other entities (95% CI, 5.2-22.3 cm 3 versus 35.1-47.6 cm 3 ; P = .03). Hemorrhage was exclusively present in non -WNT/ non -SHH medulloblastomas ( P = .04; n = 2/5). MR imaging biomarkers were all discordant from those identified in the pediatric cohort. Desmoplastic/nodular medulloblastomas were more rarely in contact with the fourth ventricle (4/15 versus 7/13; P = .04). MR imaging biomarkers can help distinguish histologic and genetic

  9. Long-term visibility variation in Athens (1931–2013: a proxy for local and regional atmospheric aerosol loads

    Directory of Open Access Journals (Sweden)

    D. Founda

    2016-09-01

    Full Text Available This study explores the interdecadal variability and trends of surface horizontal visibility at the urban area of Athens from 1931 to 2013, using the historical archives of the National Observatory of Athens (NOA. A prominent deterioration of visibility in the city was detected, with the long-term linear trend amounting to −2.8 km decade−1 (p < 0.001, over the entire study period. This was not accompanied by any significant trend in relative humidity or precipitation over the same period. A slight recovery of visibility levels seems to be established in the recent decade (2004–2013. It was found that very good visibility (>  20 km occurred at a frequency of 34 % before the 1950s, while this percentage drops to just 2 % during the decade 2004–2013. The rapid impairment of the visual air quality in Athens around the 1950s points to the increased levels of air pollution on a local and/or regional scale, related to high urbanization rates and/or increased anthropogenic emissions on a global scale at that period. Visibility was found to be negatively/positively correlated with relative humidity/wind speed, the correlation being statistically valid at certain periods. Wind regime and mainly wind direction and corresponding air mass origin were found to highly control visibility levels in Athens. The comparison of visibility variation in Athens and at a non-urban reference site on Crete island revealed similar negative trends over the common period of observations. This suggests that apart local sources, visibility in Athens is highly determined by aerosol load of regional origin. AVHRR and MODIS satellite-derived aerosol optical depth (AOD retrievals over Athens and surface measurements of PM10 confirmed the relation of visibility to aerosol load.

  10. La construcción del patrimonio arqueológico en una comunidad de la puna de Jujuy, Argentina en tiempos de globalización La construcción del patrimonio arqueológico en una comunidad de la puna de Jujuy, Argentina en tiempos de globalización

    Directory of Open Access Journals (Sweden)

    Mónica Montenegro

    2009-12-01

    Full Text Available We share some thoughts on the building of the archaeological patrimony at an Altiplano community in northwestern Argentina.The tourist development programs that are being implemented in our province in recent years have given way to changes in the traditional way of life of the local communities. Some processes of patrimony activation have been emphasized which put into value the local resources within a global context.This dynamics is also shown in the educational community, who from certain pedagogic processes, it is actively inserted in the construction of the local patrimony. We value their representations on this process and reflexion on the archaeology, education, and community relationships.Compartimos reflexiones acerca de la construcción del patrimonio arqueológico, en una comunidad altiplánica del Noroeste Argentino (NOA.Los programas de desarrollo turístico que han venido implementándose en nuestra provincia en el transcurso de los últimos años, han motivado cambios en el modo tradicional de vida de las comunidades locales. Se han enfatizado ciertos procesos de activación patrimonial que valorizan los recursos locales en un contexto globalizado.Esta dinámica también se manifiesta en la comunidad educativa que, a partir de ciertos procesos pedagógicos, participa activamente de la construcción del patrimonio local. Rescatamos sus representaciones acerca de este proceso y reflexionamos sobre la relación entre arqueología, educación y comunidad.

  11. Human adipose stem cell and ASC-derived cardiac progenitor cellular therapy improves outcomes in a murine model of myocardial infarction

    Directory of Open Access Journals (Sweden)

    Davy PMC

    2015-10-01

    Full Text Available Philip MC Davy,1 Kevin D Lye,2,3 Juanita Mathews,1 Jesse B Owens,1 Alice Y Chow,1 Livingston Wong,2 Stefan Moisyadi,1 Richard C Allsopp1 1Institute for Biogenesis Research, 2John A. Burns School of Medicine, University of Hawaii at Mānoa, 3Tissue Genesis, Inc., Honolulu, HI, USA Background: Adipose tissue is an abundant and potent source of adult stem cells for transplant therapy. In this study, we present our findings on the potential application of adipose-derived stem cells (ASCs as well as induced cardiac-like progenitors (iCPs derived from ASCs for the treatment of myocardial infarction. Methods and results: Human bone marrow (BM-derived stem cells, ASCs, and iCPs generated from ASCs using three defined cardiac lineage transcription factors were assessed in an immune-compromised mouse myocardial infarction model. Analysis of iCP prior to transplant confirmed changes in gene and protein expression consistent with a cardiac phenotype. Endpoint analysis was performed 1 month posttransplant. Significantly increased endpoint fractional shortening, as well as reduction in the infarct area at risk, was observed in recipients of iCPs as compared to the other recipient cohorts. Both recipients of iCPs and ASCs presented higher myocardial capillary densities than either recipients of BM-derived stem cells or the control cohort. Furthermore, mice receiving iCPs had a significantly higher cardiac retention of transplanted cells than all other groups. Conclusion: Overall, iCPs generated from ASCs outperform BM-derived stem cells and ASCs in facilitating recovery from induced myocardial infarction in mice. Keywords: adipose stem cells, myocardial infarction, cellular reprogramming, cellular therapy, piggyBac, induced cardiac-like progenitors

  12. Hidden osteophyte formation on plain X-ray is the predictive factor for development of knee osteoarthritis after 48 months--data from the Osteoarthritis Initiative.

    Science.gov (United States)

    Katsuragi, J; Sasho, T; Yamaguchi, S; Sato, Y; Watanabe, A; Akagi, R; Muramatsu, Y; Mukoyama, S; Akatsu, Y; Fukawa, T; Endo, J; Hoshi, H; Yamamoto, Y; Sasaki, T; Takahashi, K

    2015-03-01

    To examine whether the detection of osteophytes anywhere in the knee could serve as a pre-radiographic biomarker for osteoarthritis (OA) development. Baseline magnetic resonance imaging (MRIs) of 132 participants in the Osteoarthritis Initiative (OAI) were studied. Based on radiographs, 66 knees were assessed as osteoarthritis-free (no-osteoarthritis [NOA], or Kellgren/Lawrence [K/L] severity grade 0/1 both at baseline and 48 months), and another 66 knees were assessed as having radiographic OA changes (pre-radiographic osteoarthritis [PROA], or with K/L grade 0/1 at baseline and grade ≥ 2 at 48 months). Using baseline MRI data, we examined eight sites of osteophyte formation: the medial and lateral femoral condyle (MFC and LFC, respectively); medial and lateral tibial plateau (MTP and LTP, respectively); medial and lateral facets of the patellofemoral joint (PM and PL, respectively); tibial spine (TS); and femoral intercondylar notch (IC). Knee joint osteophyte size was assessed via the 8-point marginal osteophytes item of the whole-organ magnetic resonance imaging score (WORMS). The frequencies and distributions of osteophytes were compared between groups. Mild-size osteophytes (defined as score ≥ 2) were observed more frequently at the MFC (P = 0.00278), MTP (P = 0.0046), TS (P = 0.0146), PM (P formation at the IC, even those of K/L severity grade 0/1, are at risk for the development of radiographic OA by 48 months. Copyright © 2014 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

  13. Remote radiological assessment in the marine environment: SMOS and MODIS observations combined to {sup 137}Cs activity concentrations in the Aegean Sea - Greece - Remote radiological assessment in the marine environment: SMOS observations combined TO Cs-137 activity concentrations in the Aegean Sea Greece

    Energy Technology Data Exchange (ETDEWEB)

    Florou, H.; Tzempelikou, E. [NCSR ' Demokritos' , Institute of Nuclear and Radiological Sciences and Technology, Energy and Safety, Aghia Paraskevi 15310, POB 60037, Attiki (Greece); Sykioti, O. [National Observatory of Athens, Institute for Astronomy, Astrophysics, Space Applications and Remote Sensing, Vas. Pavlou and I. Metaxa, 15236 Penteli, Greece, Athens (Greece); Evangeliou, N. [CEA-CNRS-UVSQ UMR 8212, IPSL/LSCE Gif-sur-Yvette Cedex (France); Mavrokefalou, G. [Harokopio University, Department of Geography, 70 El. Venizelou, Kallithea, 17671, Athens (Greece)

    2014-07-01

    The capability of ordinary earth-observational satellites to record changes of ecological parameters in the environment is well documented. Nevertheless, radionuclide dispersion cannot be detected by the installed devices directly. However, the levels of radionuclides in the marine environment, especially for the soluble ones, are associated with other physical and chemical parameters of the natural environment (e.g. temperature/evaporation, water density, salinity etc). It is well known that marine dynamic processes, like horizontal advection and vertical mixing, control distribution of radionuclides in waters. The water density controls the transport of water masses among basins, which results to trans-boundary radioactive contamination. On the other hand, salinity and temperature control the water density and consequently is a major parameter for the marine radiological assessment. Nevertheless, salinity is a critical index for weathering and anthropogenic influences in the marine environment such as rainfall, evaporation, river runoff, global fallout, accidental releases, inter-regional contamination through current circulation, which are potential impact sources for the marine environment. In the present study, the activity concentrations of {sup 137}Cs in the Aegean Sea Greece combined to SMOS data are treated and simulated to models as to develop an innovative tool for the remote radioactivity detecting either for routine observations and emergency recording. Besides, the integrated by space and time field measurements to the respective satellite observations of salinity variations will create a model, which might be also applicable for the prediction of the radiological impact of potential accidental events. This presentation is the first footprint of this research under the coordinated Project AOSMOS.4681 ESA, being carried out in NOA and NCSR'D'. (authors)

  14. Determination of naphthalene-derived compounds in apples by ultra-high performance liquid chromatography-tandem mass spectrometry.

    Science.gov (United States)

    Esparza, X; Moyano, E; Cosialls, J R; Galceran, M T

    2013-06-11

    Naphthylacetic acid, naphthyloxy acetic acid and naphthylacetamide belong to a group of synthetic substances known as "auxin-like" compounds which are used as growth regulators in vegetables and fruits due to their structure similarities with the indoleacetic acid, the most important plant auxin. This paper reports a selective, sensitive and fast ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method for the determination of naphthylacetamide (NAD) and the isomers (α and β) of naphthylacetic acid (NAA) and naphthyloxy acetic (NOA) acid in apple samples. A baseline separation between the respective isomers was achieved using an RP-Amide column with gradient elution. The UHPLC-MS/MS method developed, using electrospray and selected reaction monitoring (SRM) acquisition mode led to a reliable determination of these family of compounds in apple samples at low quantitation levels, down to 1.0 μg kg(-1) and 0.25 μg kg(-1) respectively. For confirmation of NAA accurate mass measurement is proposed giving at these conditions quantitation limits of 10 μg kg(-1) for this compound. The UHPLC-MS/MS method developed was used for the analysis of apple samples harvested in three different apple fields from Lleida (Spain) during the blooming period. NAD and NAA were found in samples collected during 4-5 weeks after application at concentrations between the quantification limits and 43 μg kg(-1) and 24 μg kg(-1), respectively. Copyright © 2013 Elsevier B.V. All rights reserved.

  15. Linajes holandricos en tres poblaciones del NO Argentino

    Directory of Open Access Journals (Sweden)

    Bailliet, Graciela

    2005-01-01

    Full Text Available Los marcadores bialélicos de la región específica del cromosoma Y han permitido identificar linajes propios de continentes, y a través de su distribución geográfica pueden reconstruirse movimientos migratorios de las poblaciones humanas. Se ha generado una filogenia confiable y se cuenta con una nomenclatura que facilita la interpretación de los resultados producidos en distintos laboratorios. En el presente trabajo se utilizaron 13 SNP seleccionados por estar presentes en las poblaciones originarias de América y en las parentales para los grupos inmigrantes recientes. El objetivo de este trabajo fue identificar el origen étnico de los linajes paternos de muestras de ADN provenientes de tres ciudades del NOA: Salta, Catamarca y Tucumán. Se identificaron 6 haplogrupos, los de origen europeo fueron los mayoritarios (67%; le siguió en frecuencia el haplogrupo propio de América (15%; también se observaron linajes YAP+ (7.5%. La distribución de la frecuencia de los haplogrupos diferenció a las muestras de Catamarca de las de Salta y Tucumán (P<0.001. La mayoría de los linajes moleculares propios de América se encontraron en muestras provenientes de individuos con apellidos foráneos (87.5. Esto refleja el efecto del largo contacto temporal entre las poblaciones nativas e inmigrantes recientes, así como la influencia cultural compleja en la trasmisión de los apellidos.

  16. Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma.

    Science.gov (United States)

    Wiestler, Benedikt; Capper, David; Sill, Martin; Jones, David T W; Hovestadt, Volker; Sturm, Dominik; Koelsche, Christian; Bertoni, Anna; Schweizer, Leonille; Korshunov, Andrey; Weiß, Elisa K; Schliesser, Maximilian G; Radbruch, Alexander; Herold-Mende, Christel; Roth, Patrick; Unterberg, Andreas; Hartmann, Christian; Pietsch, Torsten; Reifenberger, Guido; Lichter, Peter; Radlwimmer, Bernhard; Platten, Michael; Pfister, Stefan M; von Deimling, Andreas; Weller, Michael; Wick, Wolfgang

    2014-10-01

    The outcome of patients with anaplastic gliomas varies considerably. Whether a molecular classification of anaplastic gliomas based on large-scale genomic or epigenomic analyses is superior to histopathology for reflecting distinct biological groups, predicting outcomes and guiding therapy decisions has yet to be determined. Epigenome-wide DNA methylation analysis, using a platform which also allows the detection of copy-number aberrations, was performed in a cohort of 228 patients with anaplastic gliomas (astrocytomas, oligoastrocytomas, and oligodendrogliomas), including 115 patients of the NOA-04 trial. We further compared these tumors with a group of 55 glioblastomas. Unsupervised clustering of DNA methylation patterns revealed two main groups correlated with IDH status: CpG island methylator phenotype (CIMP) positive (77.5 %) or negative (22.5 %). CIMP(pos) (IDH mutant) tumors showed a further separation based on copy-number status of chromosome arms 1p and 19q. CIMP(neg) (IDH wild type) tumors showed hallmark copy-number alterations of glioblastomas, and clustered together with CIMP(neg) glioblastomas without forming separate groups based on WHO grade. Notably, there was no molecular evidence for a distinct biological entity representing anaplastic oligoastrocytoma. Tumor classification based on CIMP and 1p/19q status was significantly associated with survival, allowing a better prediction of outcome than the current histopathological classification: patients with CIMP(pos) tumors with 1p/19q codeletion (CIMP-codel) had the best prognosis, followed by patients with CIMP(pos) tumors but intact 1p/19q status (CIMP-non-codel). Patients with CIMP(neg) anaplastic gliomas (GBM-like) had the worst prognosis. Collectively, our data suggest that anaplastic gliomas can be grouped by IDH and 1p/19q status into three molecular groups that show clear links to underlying biology and a significant association with clinical outcome in a prospective trial cohort.

  17. Development of a real-time PCR for detection of Staphylococcus pseudintermedius using a novel automated comparison of whole-genome sequences.

    Directory of Open Access Journals (Sweden)

    Koen M Verstappen

    Full Text Available Staphylococcus pseudintermedius is an opportunistic pathogen in dogs and cats and occasionally causes infections in humans. S. pseudintermedius is often resistant to multiple classes of antimicrobials. It requires a reliable detection so that it is not misidentified as S. aureus. Phenotypic and currently-used molecular-based diagnostic assays lack specificity or are labour-intensive using multiplex PCR or nucleic acid sequencing. The aim of this study was to identify a specific target for real-time PCR by comparing whole genome sequences of S. pseudintermedius and non-pseudintermedius.Genome sequences were downloaded from public repositories and supplemented by isolates that were sequenced in this study. A Perl-script was written that analysed 300-nt fragments from a reference genome sequence of S. pseudintermedius and checked if this sequence was present in other S. pseudintermedius genomes (n = 74 and non-pseudintermedius genomes (n = 138. Six sequences specific for S. pseudintermedius were identified (sequence length between 300-500 nt. One sequence, which was located in the spsJ gene, was used to develop primers and a probe. The real-time PCR showed 100% specificity when testing for S. pseudintermedius isolates (n = 54, and eight other staphylococcal species (n = 43. In conclusion, a novel approach by comparing whole genome sequences identified a sequence that is specific for S. pseudintermedius and provided a real-time PCR target for rapid and reliable detection of S. pseudintermedius.

  18. Technical Training: Places available

    CERN Multimedia

    Davide Vitè

    2006-01-01

    Places available as of 9.5.2006 (May-October course sessions) The number of places available may vary. Please check our Web site to find out the current availability. Places are available on the following courses: find out the curren Hours Date Language LabVIEW Application Development 24 15-17.05.06 E LabVIEW Advanced Programming 16 18-19.05.06 E PERL 5: Advanced Aspects 8 18.05.06 E Technique du vide 16 18-19.05.06 F FileMaker - niveau 2 16 11-12.05.06 F WORD 2003 - niveau 2 : ECDL 16 22-23.05.06 F Introduction au VHDL et utilisation du simulateur NCVHDL de CADENCE 16 23-24.05.06 F Comprehensive VHDL for FPGA Design 40 29.05-2.06.06 E C++ Programming Part 2 - Advanced C++ and its Traps and Pitfalls 32 30.05-2.06.06 E Python: Hands-on Introduction 24 7-9.06.06 E AutoCAD Mechanical 2006 16 13-14.06.06 F CERN EDMS for Local Administrators 16 13-14.06.06...

  19. Direct calibration of PICKY-designed microarrays

    Directory of Open Access Journals (Sweden)

    Ronald Pamela C

    2009-10-01

    Full Text Available Abstract Background Few microarrays have been quantitatively calibrated to identify optimal hybridization conditions because it is difficult to precisely determine the hybridization characteristics of a microarray using biologically variable cDNA samples. Results Using synthesized samples with known concentrations of specific oligonucleotides, a series of microarray experiments was conducted to evaluate microarrays designed by PICKY, an oligo microarray design software tool, and to test a direct microarray calibration method based on the PICKY-predicted, thermodynamically closest nontarget information. The complete set of microarray experiment results is archived in the GEO database with series accession number GSE14717. Additional data files and Perl programs described in this paper can be obtained from the website http://www.complex.iastate.edu under the PICKY Download area. Conclusion PICKY-designed microarray probes are highly reliable over a wide range of hybridization temperatures and sample concentrations. The microarray calibration method reported here allows researchers to experimentally optimize their hybridization conditions. Because this method is straightforward, uses existing microarrays and relatively inexpensive synthesized samples, it can be used by any lab that uses microarrays designed by PICKY. In addition, other microarrays can be reanalyzed by PICKY to obtain the thermodynamically closest nontarget information for calibration.

  20. Science Me! | 09-10 July | Geneva

    CERN Multimedia

    2016-01-01

    The 11th Nuit de la Science (see here) will happen on July 9 and 10 on the theme "The Rules of the Game" in the gorgeous park of the Perle-du-Lac showcasing the Museum of Science History, organizer of this event that attracts 30-35,000 visitors on each edition.   On this occasion, the Chimiscope and the Museum of Science History invite the public to take part to Science Me!, the first European science show competition. Under a large circus tent, teams of young scientists from all origins and practicing all sciences will compete under the form of 10-minute shows, in French or in English. At the end of each show, the audience will also be able to interact and converse with the participating teams. The success of the demonstrations will be measured by applausemeter, while a jury of neutral and independent scientists will evaluate the qualit...