WorldWideScience

Sample records for nitajana noorsportlaste 9-16

  1. 46 CFR 9.16 - Billing for services.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Billing for services. 9.16 Section 9.16 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC EXTRA COMPENSATION FOR OVERTIME SERVICES § 9.16 Billing for services. Overtime services shall be billed to the steamship companies...

  2. A case with laryngeal atresia and partial trisomy 9 due to maternal 9;16 translocation

    NARCIS (Netherlands)

    van den Boogaard, M. J.; de Pater, J.; Hennekam, R. C.

    1991-01-01

    A newborn with a partial trisomy 9 and a partial trisomy 16q is described. The child died shortly after birth because of laryngeal atresia. The chromosome anomaly was the result of a 3:1 segregation of a maternal translocation t(9;16) (q22;q24). The pertinent literature on both partial trisomy 9 and

  3. Maternal protein intake in pregnancy and offspring metabolic health at age 9-16 y

    DEFF Research Database (Denmark)

    Maslova, Ekaterina; Hansen, Susanne; Grunnet, Louise Groth

    2017-01-01

    in free-living populations remains limited. Objective: We examined the association of protein intake in pregnancy with offspring metabolic health at age 9-16 y in a longitudinal cohort that oversampled pregnancies with gestational diabetes mellitus (GDM). Design: Six hundred eight women with an index...... including fasting blood samples and a dual-energy X-ray absorptiometry scan (subset of 650) from which metabolic outcomes were derived. Multivariable analyses were conducted applying a 1:1 substitution of carbohydrates for protein. Results: The mean ± SD protein intake in pregnancy was 93 ± 15 g/d (16% ± 3...

  4. Reliability and construct validity of Yo-Yo tests in untrained and soccer-trained school-girls aged 9-16

    DEFF Research Database (Denmark)

    Póvoas, Susana C A; Castagna, Carlo; Soares, José Manuel da Costa

    2016-01-01

    Purpose: The reliability and construct validity of three age-adapted-intensity Yo-Yo tests were evaluated in untrained (n=67) vs. soccer-trained (n=65) 9-16-year-old school-girls. Methods: Tests were performed 7 days apart for reliability (9-11-year-old: Yo-Yo intermittent recovery level 1 children...... during test and retest. Conclusion: The Yo-Yo tests are reliable for determining intermittent-exercise capacity and %HRpeak for soccer players and untrained 9-16-year-old girls. They also possess construct validity with better performances for soccer players compared to untrained age-matched girls......’s test; 12-13-year-old: Yo-Yo intermittent endurance level 1; and 14-16-year-old: Yo-Yo intermittent endurance level 2). Results: Yo-Yo distance covered was 43% (747±364 vs. 522±162 m), 83% (1236±514 vs. 674±231 m) and 137% (679±348 vs. 286±67 m) greater (P≤0.010) for the soccer-trained than...

  5. Maternal protein intake in pregnancy and offspring metabolic health at age 9-16 y: results from a Danish cohort of gestational diabetes mellitus pregnancies and controls

    DEFF Research Database (Denmark)

    Maslova, Ekaterina; Hansen, Susanne; Grunnet, Louise Groth

    2017-01-01

    in free-living populations remains limited.Objective: We examined the association of protein intake in pregnancy with offspring metabolic health at age 9-16 y in a longitudinal cohort that oversampled pregnancies with gestational diabetes mellitus (GDM).Design: Six hundred eight women with an index...... pregnancy affected by gestational diabetes mellitus and 626 controls enrolled in the Danish National Birth Cohort were used for the analysis. Protein (total, animal, vegetable) intake was assessed by using a food frequency questionnaire in gestational week 25. The offspring underwent a clinical examination...... including fasting blood samples and a dual-energy X-ray absorptiometry scan (subset of 650) from which metabolic outcomes were derived. Multivariable analyses were conducted applying a 1: 1 substitution of carbohydrates for protein.Results: The mean +/- SD protein intake in pregnancy was 93 +/- 15 g/d (16...

  6. Maternal protein intake in pregnancy and offspring metabolic health at age 9-16 y: results from a Danish cohort of gestational diabetes mellitus pregnancies and controls.

    Science.gov (United States)

    Maslova, Ekaterina; Hansen, Susanne; Grunnet, Louise Groth; Strøm, Marin; Bjerregaard, Anne Ahrendt; Hjort, Line; Kampmann, Freja Bach; Madsen, Camilla Møller; Baun Thuesen, A C; Bech, Bodil Hammer; Halldorsson, Thorhallur I; Vaag, Allan A; Olsen, Sjurdur F

    2017-08-01

    Background: Recent years have seen strong tendencies toward high-protein diets. However, the implications of higher protein intake, especially during developmentally sensitive periods, are poorly understood. Conversely, evidence on the long-term developmental consequences of low protein intake in free-living populations remains limited. Objective: We examined the association of protein intake in pregnancy with offspring metabolic health at age 9-16 y in a longitudinal cohort that oversampled pregnancies with gestational diabetes mellitus (GDM). Design: Six hundred eight women with an index pregnancy affected by gestational diabetes mellitus and 626 controls enrolled in the Danish National Birth Cohort were used for the analysis. Protein (total, animal, vegetable) intake was assessed by using a food-frequency questionnaire in gestational week 25. The offspring underwent a clinical examination including fasting blood samples and a dual-energy X-ray absorptiometry scan (subset of 650) from which metabolic outcomes were derived. Multivariable analyses were conducted applying a 1:1 substitution of carbohydrates for protein. Results: The mean ± SD protein intake in pregnancy was 93 ± 15 g/d (16% ± 3% of energy) in GDM-exposed women and 90 ± 14 g/d (16% ± 2% of energy) in control women. There were overall no associations between maternal protein intake and offspring fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR). We found that maternal total protein intake was associated with a tendency for a higher abdominal fat mass percentage (quartile 4 compared with quartile 1: 0.40 SD; 95% CI: -0.03, 0.83 SD; P = 0.07) in GDM-exposed offspring and a tendency for a higher total fat mass percentage among male offspring (quartile 4 compared with quartile 1: 0.33 SD; 95% CI: -0.01, 0.66 SD; P = 0.06), but a small sample size may have compromised the precision of the effect estimates. GDM-exposed offspring of mothers with a protein intake in the

  7. Indonesian Basic Course: Volume II, Lessons 9-16.

    Science.gov (United States)

    Defense Language Inst., Washington, DC.

    This is a field-test edition of the revised "Indonesian Basic Course," prepared by the Defense Language Institute. Lessons are structured around language pattern recognition exercises, dialogue mastery and translation, and a review of grammar. Cultural notes and vocabulary lists are included. Lessons concern: (1) occupations, (2) color, (3) points…

  8. Report of the IMFIT Advisory Committee from the Meeting of 9/16/08 at General Atomics

    International Nuclear Information System (INIS)

    Cohen, R.; Cary, J.; Houlberg, W.; McCune, D.

    2008-01-01

    The Committee commends and thanks the presenters and GA for providing clear and informative presentations. We present our responses to 5 questions raised in the Charge, as well as additional comments that may be useful for the project. (Question 1) The IMFIT framework is based on PYTHON and CCA; can IMFIT meet its long-term goals with this choice of language for framework? Our first recommendation is to change the terminology; it appears that the project is not really utilizing CCA (Common Component Architecture). The project is really about using Python to organize workflow among components that are spawned as processes via pipes from Python. We suggest that in describing the project, the team drop the designation 'CCA' and simply state that the IMFIT framework is based on using Python to control workflow among components. Concerning the specific question: we understand the principal goal of the project to be the development of an easy-to-use tool that efficiently integrates different physics modules to support experimental data analysis and modeling. Yes, Python and the workflow-based framework are appropriate choices for meeting this objective. The Committee, in examining the goal, discussed whether the IMFIT project was duplicative of other projects; there are several others in the U.S. and elsewhere with integrated modeling goals. In particular in the U.S., SWIM, PTRANSP, and the proto-FSP's. However this project occupies a reasonably unique niche through its emphases on integrating experimental data, use of existing components, its near-term focus, and the extent to which is targeted at experimentalist users. (Question 2) Will IMFIT benefit from the additional use of an interoperability language for framework such as BABEL? No, IMFIT is not really doing inter-language communication. In particular this will be the case as long as inter-component communication is via files--and that's OK so long as you aren't doing lots of short steps with communication at each step. (Question 3) IMFIT GUI is based on the public PyGTK toolkit; will IMFIT benefit from the additional use of other public Python graphic toolkits such as wxPython that is a cross-platform wrapper, or PyQt, or a commercial package such as IDL? PyGTK seems adequate for now. The team needs to decide if it needs more capability. Avoid licensed software that interferes with portability and the open-source goal (and thus in particular avoid IDL). (Question 4) Will IMFIT benefit from using a XML-RPC as alternative to sending files thru sockets? IMFIT could benefit by adopting some kind of self-describing format, such as XML or HDF5, but data can still be sent over sockets. This is part of a broader question: 'Should IMFIT adopt some kind of standard for communicating data between components?' To do anything other than what is done now requires modification of individual components (or convertors/wrappers). But moving to a self-describing standard is a good idea, which should be considered. You don't need to impose a standard, but you could decide on one and move toward it gradually, as the architecture doesn't impose a standard. But whether you adopt a standard and the pace of moving toward it is up to you. (Question 5) Will IMFIT benefit from any other available computational tool? (a) IMFIT would benefit from fuller use of an already incorporated tool--python language in the task execution specification, to enable desired features like branching; (b) If there is a high degree of data hierarchy, IMFIT should explore HDF5 as well as NETCDF and compare; (c) IMFIT would benefit from moving toward common data standards; (d) It would be useful for the IMFIT team to monitor developments in related projects such as the proto-FSP's and PTRANSP to ascertain if there are potentially useful tools

  9. Proceedings of the 21st DOE/NRC nuclear air cleaning conference; Volume 2, Sessions 9--16

    Energy Technology Data Exchange (ETDEWEB)

    First, M.W. [ed.] [Harvard Univ., Boston, MA (United States). Harvard Air Cleaning Lab.

    1991-02-01

    The 21st meeting of the Department of Energy/Nuclear Regulatory Commission (DOE/NRC) Nuclear Air Cleaning Conference was held in San Diego, CA on August 13--16, 1990. The proceedings have been published as a two volume set. Volume 2 contains sessions covering adsorbents, nuclear codes and standards, modelling, filters, safety, containment venting and a review of nuclear air cleaning programs around the world. Also included is the list of attendees and an index of authors and speakers. (MHB)

  10. Measuring the Return on Investment in TVET. Report of the UNESCO-UNEVOC Virtual Conference, 9-16 May 2016

    Science.gov (United States)

    UNESCO-UNEVOC International Centre for Technical and Vocational Education and Training, 2016

    2016-01-01

    Sustainable Development Goals call on Members States to "ensure inclusive and equitable quality education and promote lifelong learning opportunities for all" and sets a number of targets related to technical and vocational education and training (TVET). In order to collect input from the global TVET community, UNESCO-UNEVOC organized a…

  11. Report of the IMFIT Advisory Committee from the Meeting of 9/16/08 at General Atomics

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, R; Cary, J; Houlberg, W; McCune, D

    2008-10-22

    The Committee commends and thanks the presenters and GA for providing clear and informative presentations. We present our responses to 5 questions raised in the Charge, as well as additional comments that may be useful for the project. (Question 1) The IMFIT framework is based on PYTHON and CCA; can IMFIT meet its long-term goals with this choice of language for framework? Our first recommendation is to change the terminology; it appears that the project is not really utilizing CCA (Common Component Architecture). The project is really about using Python to organize workflow among components that are spawned as processes via pipes from Python. We suggest that in describing the project, the team drop the designation 'CCA' and simply state that the IMFIT framework is based on using Python to control workflow among components. Concerning the specific question: we understand the principal goal of the project to be the development of an easy-to-use tool that efficiently integrates different physics modules to support experimental data analysis and modeling. Yes, Python and the workflow-based framework are appropriate choices for meeting this objective. The Committee, in examining the goal, discussed whether the IMFIT project was duplicative of other projects; there are several others in the U.S. and elsewhere with integrated modeling goals. In particular in the U.S., SWIM, PTRANSP, and the proto-FSP's. However this project occupies a reasonably unique niche through its emphases on integrating experimental data, use of existing components, its near-term focus, and the extent to which is targeted at experimentalist users. (Question 2) Will IMFIT benefit from the additional use of an interoperability language for framework such as BABEL? No, IMFIT is not really doing inter-language communication. In particular this will be the case as long as inter-component communication is via files--and that's OK so long as you aren't doing lots of short steps with communication at each step. (Question 3) IMFIT GUI is based on the public PyGTK toolkit; will IMFIT benefit from the additional use of other public Python graphic toolkits such as wxPython that is a cross-platform wrapper, or PyQt, or a commercial package such as IDL? PyGTK seems adequate for now. The team needs to decide if it needs more capability. Avoid licensed software that interferes with portability and the open-source goal (and thus in particular avoid IDL). (Question 4) Will IMFIT benefit from using a XML-RPC as alternative to sending files thru sockets? IMFIT could benefit by adopting some kind of self-describing format, such as XML or HDF5, but data can still be sent over sockets. This is part of a broader question: 'Should IMFIT adopt some kind of standard for communicating data between components?' To do anything other than what is done now requires modification of individual components (or convertors/wrappers). But moving to a self-describing standard is a good idea, which should be considered. You don't need to impose a standard, but you could decide on one and move toward it gradually, as the architecture doesn't impose a standard. But whether you adopt a standard and the pace of moving toward it is up to you. (Question 5) Will IMFIT benefit from any other available computational tool? (a) IMFIT would benefit from fuller use of an already incorporated tool--python language in the task execution specification, to enable desired features like branching; (b) If there is a high degree of data hierarchy, IMFIT should explore HDF5 as well as NETCDF and compare; (c) IMFIT would benefit from moving toward common data standards; (d) It would be useful for the IMFIT team to monitor developments in related projects such as the proto-FSP's and PTRANSP to ascertain if there are potentially useful tools.

  12. Knowledge Based Economic Areas and Flagship Universities: A Look at the New Growth Ecosystems in the US and California. Research & Occasional Paper Series: CSHE.9.16

    Science.gov (United States)

    Douglass, John Aubrey

    2016-01-01

    The acceptance of new growth theory relates, in part, to a number of highly touted regional success stories--or what I term "Knowledge Based Economic Areas" (KBEAs) in this and past essays. The United States, and California in particular, is viewed as perhaps the most robust creators of KBEAs, providing an influential model that is…

  13. 29. mezinárodní sympozium ICTM Study Group on Ethnochoreology, Graz, Retzhof Castle, Rakousko 9.-16. 7. 2016

    Czech Academy of Sciences Publication Activity Database

    Stavělová, Daniela

    2016-01-01

    Roč. 103, č. 4 (2016), s. 664-666 ISSN 0009-0794 Institutional support: RVO:68378076 Keywords : symposium * ethnochoreology * dance * urban space * Graz Subject RIV: AC - Archeology, Anthropology, Ethnology

  14. Supplement Analysis for the Transmission System Vegetation Management Program FEIS (DOE/EIS-0285/SA-124 (Echo Lake-Maple Valley #1 [Mile 9-16], Adno 8258)

    Energy Technology Data Exchange (ETDEWEB)

    Shurtliff, Aaron [Bonneville Power Administration (BPA), Portland, OR (United States)

    2003-02-18

    Vegetation Management for portion of the Echo Lake – Maple Valley #1 500 kV transmission line located from tower structure 9/2 to 16/5. BPA proposes to clear targeted vegetation within the Right-of-Ways along access roads and around towers that may impede the operation and maintenance of the subject transmission lines. See Section 1.4 of the attached checklists for a complete description of the proposed action.

  15. 4,5,7,8,17-Pentahydroxy-14,18-dimethyl-6-methylene-3,10-dioxapentacyclo[9.8.0.01,7.04,19.013,18]nonadec-14-ene-9,16-dione methanol solvate dihydrate

    Directory of Open Access Journals (Sweden)

    Chin Hoe Teh

    2009-04-01

    Full Text Available The title quassinoid compound, C20H24O9·CH3OH·2H2O, is a natural eurycomanone isolated from the roots of Eurycoma longifolia. The molecules contain a fused five-ring system, with one tetrahydrofuran ring adopting an envelope conformation, one tetrahydropyran-2-one ring in a screw boat conformation, one cyclohexenone ring in a half-chair conformation and two cyclohexane rings in chair conformations. Intramolecular C—H...O interactions generate S(5 ring motifs and an O—H...O interaction generates an S(7 ring motif. In the crystal, molecules are linked via intermolecular O—H...O interactions along the b axis and further stacked along a axis. The absolute configuration of the title compound was inferred from previously solved structures of its analogues.

  16. Report from the Rockefellar Foundation Sponsored International Workshop on reducing mortality and improving quality of life in long-term survivors of Hodgkin's disease: July 9-16, 2003, Bellagio, Italy

    DEFF Research Database (Denmark)

    Mauch, Peter; Ng, Andrea; Aleman, Berthe

    2005-01-01

    A workshop, sponsored by the Rockefellar Foundation, was held between 9 to 16 July, 2003 to devise strategies to reduce mortality and improve quality of life of long-term survivors of Hodgkin's disease. Participants were selected for their clinical and research background on late effects after...... Hodgkin's disease therapy. Experts from both developed and developing nations were represented in the workshop, and efforts were made to ensure that the proposed strategies would be globally applicable whenever possible. The types of late complications, magnitude of the problem, contributing risk factors...

  17. Physical activity attenuates the mid-adolescent peak in insulin resistance but by late adolescence the effect is lost: a longitudinal study with annual measures from 9-16 years (EarlyBird 66).

    Science.gov (United States)

    Metcalf, Brad S; Hosking, Joanne; Henley, William E; Jeffery, Alison N; Mostazir, Mohammod; Voss, Linda D; Wilkin, Terence J

    2015-12-01

    The aim of this work was to test whether the mid-adolescent peak in insulin resistance (IR) and trends in other metabolic markers are influenced by long-term exposure to physical activity. Physical activity (7 day ActiGraph accelerometry), HOMA-IR and other metabolic markers (glucose, fasting insulin, HbA1c, lipids and BP) were measured annually from age 9 years to 16 years in 300 children (151 boys) from the EarlyBird study in Plymouth, UK. The activity level of each child was characterised, with 95% reliability, by averaging their eight annual physical activity measures. Age-related trends in IR and metabolic health were analysed by multi-level modelling, with physical activity as the exposure measure (categorical and continuous) and body fat percentage (assessed by dual-energy X-ray absorptiometry) and pubertal status (according to age at peak height velocity and Tanner stage) as covariates. The peak in IR at age 12-13 years was 17% lower (p adolescents independently of body fat percentage and pubertal status. However, this difference diminished progressively over the next 3 years and had disappeared completely by the age of 16 years (e.g. difference was -14% at 14 years, -8% at 15 years and +1% at 16 years; 'physical activity × age(2), interaction, p adolescence in the more active group. Our finding that physical activity attenuates IR during mid-adolescence may be clinically important. It remains to be established whether the temporary attenuation in IR during this period has implications for the development of diabetes in adolescence and for future metabolic health generally.

  18. CCDC 875408: Experimental Crystal Structure Determination : [(1,9-dimethyl-1,3a,9,16c-tetrahydrodibenzo[de,op]pentacene-7,15-diyl)diethyne-2,1-diyl]bis[tri(propan-2-yl)silane

    KAUST Repository

    Li, Yuan

    2013-01-01

    An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

  19. Tools Related to the Federal Tobacco Products Regulations: What Retailers Need to Know PSA (:30)

    Centers for Disease Control (CDC) Podcasts

    2010-09-16

    PSA to announce a new mobile text message program that will help raise retailers' awareness of the new federal tobacco regulations.  Created: 9/16/2010 by The CDC Division of News and Electronic Media and the FDA Center for Tobacco Products.   Date Released: 9/16/2010.

  20. Recognizing and Preventing Whooping Cough 2 (Pertussis)

    Centers for Disease Control (CDC) Podcasts

    2010-09-16

    This podcast encourages everyone to get vaccinated against whooping cough (pertussis), especially those who will have close contact with an infant.  Created: 9/16/2010 by National Center for Immunization and Respiratory Diseases (NCIRD).   Date Released: 9/16/2010.

  1. Epidermis structure and blood parameter differences between sculpin Cottus gobio and Siberian sculpin Cottus poecilopus from the Morava watershed

    Czech Academy of Sciences Publication Activity Database

    Halačka, Karel; Vítek, T.; Vetešník, Lukáš; Spurný, P.

    2012-01-01

    Roč. 61, č. 1 (2012), s. 9-16 ISSN 0139-7893 Institutional support: RVO:68081766 Keywords : goblet cell * sacciform cell * erythrocyte * leucocyte Subject RIV: EG - Zoology Impact factor: 0.494, year: 2012

  2. Some observations on contemporary teaching of archaeology in universities

    Czech Academy of Sciences Publication Activity Database

    Gojda, Martin

    2012-01-01

    Roč. 64, č. 1 (2012), s. 9-16 ISSN 0081-3834 Institutional research plan: CEZ:AV0Z80020508 Keywords : archaeology * university studies * teaching strategy * interpretive openness * archaeological sources Subject RIV: AC - Archeology, Anthropology, Ethnology

  3. President Ilves kohtus Ameerika Ühendriikide presidendi Barack Obamaga

    Index Scriptorium Estoniae

    2009-01-01

    President Toomas Hendrik Ilves kohtus 15. juunil 2009 Washingtonis USA presidendi Barack Obama ja tema julgeolekunõuniku James Jonesiga. Vabariigi President töövisiidil Ameerika Ühendriikides 9.-16.06.2009

  4. Waterborne Commerce of the United States Calendar Year 1987. Part 2. Waterways and Harbors Gulf Coast, Mississippi River System and Antilles

    Science.gov (United States)

    1989-05-31

    PRODUCTS.... ....................................................... 5,80 5,05. ........... .......... 2813 ALCOOLS ...1 I. ................... .......... .......... 2813 ALCOOLS ....................................................... 2,722...141,070 293,162 2613 ALCOOLS --- *------------------- 1,456,696 ,91R5 9,16e

  5. Eesti õpetajate roll laste internetikasutuse sotsiaalses vahendamises / Kadri Soo, Veronika Kalmus, Mare Ainsaar

    Index Scriptorium Estoniae

    Soo, Kadri

    2015-01-01

    Artiklis käsitletakse õpetajate rolli laste ettevalmistamisel internetimaailma ohtudega toimetulekuks ning analüüsitakse Eesti õpetajate tegevust 9-16aastaste laste internetikasutuse sotsiaalses vahendamises

  6. Minut maksab! : 1.- 40 : [humoreskid] / Lembit Sibul

    Index Scriptorium Estoniae

    Sibul, Lembit

    1997-01-01

    Järg: 14., 21. ja 28. nov. ; 5., 12. ja 19. dets. 1998. a.: 1., 9., 16., 23. ja 30. jaan. ; 6. ja 20. veebr. ; 6. ja 20. märts ; 9., 24. ja 30. apr.; 29. mai ; 12. juuni ; 10. ja 17. juuli; 14., 21. ja 28. aug.; 11., 18. ja 25. sept. ; 9., 16., 23. ja 30. okt. ; 6., 13., 20. ja 27. nov.; 11. ja 24. dets

  7. 76 FR 59676 - Combined Notice of Filings #1

    Science.gov (United States)

    2011-09-27

    ... MBR Tariff to be effective 10/1/2011. Filed Date: 09/16/2011. Accession Number: 20110916-5146. Comment... 35.1: ONEOK Energy Services Company Baseline MBR Filing to be effective 9/16/2011. Filed Date: 09/16... Services Order No. 697 Compliance Filing of MBR Tariff to be effective 9/16/2011. Filed Date: 09/16/2011...

  8. Kilde Hiiumaa maleajaloost / Volli Mäeumbaed

    Index Scriptorium Estoniae

    Mäeumbaed, Volli

    1999-01-01

    Järgneb 19.,26. nov., 3.,10.,17.,24.,31. dets. ; 2000, 7.,14.,21.,28. jaan, 4.,11.,18.,26. veebr., 3.,10.,17.,24.,31. märts, 7.,14.,20.,28. apr., 5.,12.,19.,26. mai, 2.,9.,16.,22. juuni, 28. juuli, 4.,11.,25. aug., 1.,8.,15.,22. sept., 20.,27. okt.,3., 10.,17.,24. nov., 1.,8.,15.,22.,29.dets. ; 2001, 19.,26. jaan., 2.,9.,16.,23. veebr., 2.,9.,16.,23.,30. märts, 6.,12.,20.,27. apr., 4.,11. mai

  9. Tundmatu Venemaa kosmonautika / Jüri Liim

    Index Scriptorium Estoniae

    Liim, Jüri

    2001-01-01

    Järgneb 7.,14. aug., 4.,18.,25. sept., 2.,23.,30. okt., 6.,13.,20. nov., 4.,11.,18. dets. ; 2002, 22.,29. jaan., 5.,12.,19.,26. veeb., 12.,19. märts ; 2.,9.,16.,23. aprill ; 7.,14.,21.,28. mai ; 4.,11.,18. juuni ; 2.,9.,16.,23.,30. juuli ; 6.,13.,27. aug., 3.,10.,17.,24. sept., 1.,8.,15.,22.,29. okt., 5.,12.,19.,26. nov., 3.,10.,17. dets. ; 2003, 7.14.,21.,28. jaan., 4.,11. veebr., 4.,11.,18. märts, 1.,8.,22.,30. apr., 6.,13.,20.,27. mai, 3.,10.,17. juuni, 1.,15.,22.,29. juuli, 5.,12.,26. aug., 2.,9.,16. sept.

  10. Eesti Vabariigi ametiühingud : ajalooline ülevaade (1918-1940) / Lembit Kiik

    Index Scriptorium Estoniae

    Kiik, Lembit

    1995-01-01

    Järgneb 11.,26. jaan., 9.,16.,23. veebr., 9.,23.,30. märts, 13. apr., 4. mai, 1.,8.,15.,22.,29. juuni, 3.,10.,17.,24.,31. aug., 7.,21.,28. sept., 5.,12.,19.,26. okt., 9.,16.,23.,30. nov., 7. dets. ; 1996, 18.,25. jaan., 1.,8.,22.,29. veebr., 14.,21..,28. märts, 4.,11.,18. apr., 30. mai, 13. juuni, 15.,22.,29. aug., 5.,12.,19.,26. sept., 4.,10.,31. okt., 7.,14.,2. nov.

  11. Novel Polymers for High Efficiency Renewable and Portable Power Applications

    Science.gov (United States)

    2015-07-30

    load weights are due to the traditional chemical batteries in order to power the devices in a 24-hours period. For any flying objects in the air or...study. (a) meso-Tetra(4- carboxyphenyl)porphine (TCPP), (b) Chloro(protoporphyrinato)iron(III) (Hemin), (c) Protoporphyrin, (d) Zinc 2, 9, 16, 23... Zinc 2, 9, 16, 23-tetra-tert-butyl-29H, 31H-phthalocyanine (ZnPC), (e) cis-Bis(isothiocyanato)(2,2′- bipyridyl-4,4′-dicarboxylato)(4,4′-di-nonyl-2

  12. Akibat Hukum Bagi Bank Bila Kewajiban Modal Inti Minimum Tidak Terpenuhi

    Directory of Open Access Journals (Sweden)

    Indira Retno Aryatie

    2012-02-01

    Full Text Available As an implementation of the Indonesian Banking Architecture policy, the government issues Bank Indonesia Regulation No. 9/16/ PBI/2007 on Minimum Tier One Capital that increases the minimum capital to 100 billion rupiah. This writing discusses the legal complication that a bank will face should it fail to fulfil the minimum ratio. Sebagai tindak lanjut dari kebijakan Arsitektur Perbankan Indonesia, pemerintah mengeluarkan Peraturan Bank Indonesia 9/16/PBI/2007 tentang Kewajiban Modal Inti Minimum Bank yang menaikkan modal inti minimum bank umum menjadi 100 miliar rupiah. Tulisan ini membahas akibat hukum yang akan dialami bank bila kewajiban modal minimum tersebut gagal dipenuhi.

  13. Selective activation around the left occipito-temporal sulcus for words relative to pictures: Individual variability or false positives?

    NARCIS (Netherlands)

    Wright, Nicholas D.; Mechelli, Andrea; Noppeney, Uta; Veltman, Dick J.; Rombouts, Serge A. R. B.; Glensman, Janice; Haynes, John-Dylan; Price, Cathy J.

    2008-01-01

    We used high-resolution fMRI to investigate claims that learning to read r !sults in greater left occipito-temporal (OT) activation for written words relative to pictures of objects. In tl e first experiment, 9/16 subjects performing a one-back task showed activation in >= 1 left OT voxel for word:

  14. LAW OCRACY ELOPMENT LAW DEMOCRACY & DEVELOPMENT

    African Journals Online (AJOL)

    HP27975994114

    application of res judicata and issue estoppel to commercial arbitrations” (2016) Arbitration & ADR 1 at 1-. 2; Voet J Commentarius ad pandectas (Lyon: apud fratres De Tournes 1778) 42.1.1; and Roodt (2012) at. 502-503). 3 See paras 3, 9 & 16. 4 Notably, the term “issue estoppel” prohibits the re-litigation of the same ...

  15. Factors Influencing Health Beliefs Among People in South West ...

    African Journals Online (AJOL)

    Administrator

    Items 9 - 16 ... drugs and medicines, heredity, contagion (not germ theory, but belief that many illnesses can be acquired ... hereditary cluster of sentiment patterns which vary considerably from one group to another within the ... presentation of depressive illness among Africans has been complicated by various cultural factors, ...

  16. The ontogeny of kin recognition in tadpoles of the toad Bufo ...

    Indian Academy of Sciences (India)

    Unknown

    114 ± 28. K9. 16*. 4. 320 ± 36*. 122 ± 33. K1–K10 represent test tadpoles from 10 different parental lines. aCompared using binomial test. bTime spent in sibling zone was compared with a random expectation using Wilcoxon signed rank test. *P < 0⋅05. Fisher's procedure of combining probabilities for overall result:.

  17. President Ilves : There Is A Future In Co-Operation Between Estonia's State-Of-The Art Companies And The World

    Index Scriptorium Estoniae

    2009-01-01

    President Toomas Hendrik Ilvese külaskäigust teadus- ja kõrgtehnoloogia keskusesse Silicon Valley'sse ning kohtumisest Stanfordi Ülikooli rektori John L. Hennessy'ga. Vabariigi President töövisiidil Ameerika Ühendriikides 9.-16.06.2009

  18. Silencing distressed children in the context of war in northern Uganda: An analysis of its dynamics and its health consequences.

    NARCIS (Netherlands)

    Akello, G.; Reis, R.; Richters, A.

    2010-01-01

    Children in northern Uganda who are the focus of this article were born and raised in the context of war. The research presented here is based on a one-year ethnographic study (2004-2005) with children aged 9-16 years. Various qualitative and quantitative methods used in this study were geared to

  19. Hypoglycaemic and Hypolipidemic Effects of Root Extracts of ...

    African Journals Online (AJOL)

    acer

    Fractionation of Aqueous Crude Extract: The. 10% reconstituted extract was subjected to further fractionation by extracting with equal volume of different .... Table 2: Serum glucose levels (mmol/L) of rats treated with root extracts of A. chevalieri. Group. Glucose. % Blood Glucose. Reduction. DU. 9.16± 0.06a. NU. 5.11± 0.15.

  20. AcSDKP is down-regulated in anaemia induced by Trypanosoma ...

    African Journals Online (AJOL)

    Mice were either infected or left uninfected (N = 100). At days 0, 9, 16, 23, 30, 37, and 44 post-infection, mice were euthanised and blood was collected by cardiac puncture to examine for parasitaemia and packed cell volume (PCV) and then centrifuged for plasma, which was used for cytokine ELISA. The mice's femurs.

  1. Experiment list: SRX326888 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available SRX326888 hg19 TFs and others GABPA Blood Jurkat Primary Tissue=Blood|Tissue Diagno...sis=Leukemia Acute Lymphocytic 55379927,95.9,16.4,27120 GSM1193663: Jurkat GABPa 2; Homo sapiens; ChIP-Seq source_name=Jurkat... cell line || cell line=Jurkat || chip antibody=GABPa || chip antibody manufacturer=Santa C

  2. ECAJS Vol 15 no 1 FINAL April 2010 _Repaired_ to Bioline 6th ...

    African Journals Online (AJOL)

    user

    2010-06-06

    Jun 6, 2010 ... duration, blood loss and emergent case status as well as the use of fingers rather than an instrument to hold the tissues 4,9,16 ... health-care professional. The only way to reduce the cumulative risk of occupational HIV infection is to reduce the number of ... be substituted by plastic 62. Other more recently ...

  3. Age effects and normative data on a Dutch test battery for auditory processing disorders.

    NARCIS (Netherlands)

    Neijenhuis, C.A.M.; Snik, A.F.M.; Priester, G.; Kordenoordt, S. van; Broek, P. van den

    2002-01-01

    A test battery compiled to diagnose auditory processing disorders (APDs) in an adult population was used on a population of 9-16-year-old children. The battery consisted of eight tests (words -in noise, filtered speech, binaural fusion, dichotic digits, frequency and duration patterns, backward

  4. Digital literacy and safety skills

    NARCIS (Netherlands)

    Sonck, N.; Livingstone, S.; Kuiper, E.; de Haan, J.

    2011-01-01

    Children’s digital skills were assessed by asking 25,000 European 9-16 year old internet users about their online activities, skills and self-efficacy. The range of digital skills and online activities are linked. But many younger (11-13 year old) children lack key critical and safety skills. Also,

  5. Relationship of Depression and Assertiveness in Normal Population ...

    African Journals Online (AJOL)

    Findings further reveal that men and women both can equally be the victim of depression in their life. Findings also suggest that married people are more assertive in comparison with unmarried people. Keywords: Depression, Assertiveness, Relationship, Gender Internet Journal of Medical Update Vol. 1 (2) 2006: pp. 9-16.

  6. Numerical analysis of twin thickening process in magnesium alloys

    Czech Academy of Sciences Publication Activity Database

    Šiška, Filip; Stratil, Luděk; Čížek, J.; Ghaderi, A.; Barnett, M.

    2017-01-01

    Roč. 124, FEB (2017), s. 9-16 ISSN 1359-6454 R&D Projects: GA ČR GJ15-21292Y Institutional support: RVO:68081723 Keywords : Magnesium alloy * Twinning * Crystal plasticity * FEM Subject RIV: JG - Metallurgy OBOR OECD: Materials engineering Impact factor: 5.301, year: 2016

  7. Two-dimensional zeolites: Adsorption of carbon dioxide on pristine materials and on materials modified by magnesium oxide

    Czech Academy of Sciences Publication Activity Database

    Zukal, Arnošt; Kubů, Martin; Pastva, Jakub

    2017-01-01

    Roč. 21, OCT 2017 (2017), s. 9-16 ISSN 2212-9820 R&D Projects: GA ČR(CZ) GAP106/12/0189 Institutional support: RVO:61388955 Keywords : Carbon dioxide adsorption * Two-dimensional zeolites * Magnesium oxide incorporation Subject RIV: CF - Physical ; Theoretical Chemistry OBOR OECD: Physical chemistry Impact factor: 4.292, year: 2016

  8. Archives of Medical and Biomedical Research - Vol 3, No 1 (2016)

    African Journals Online (AJOL)

    Suicide Prevention: does it work? EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Arun Kumar Agnihotri, Okezie I. Aruoma, 9-16. http://dx.doi.org/10.4314/ambr.v3i1.2 ...

  9. Effects of Cognitive-Behavioral Therapy on Anxiety in Children with Autism Spectrum Disorders: A Randomized Controlled Trial

    Science.gov (United States)

    Sung, Min; Ooi, Yoon Phaik; Goh, Tze Jui; Pathy, Pavarthy; Fung, Daniel S. S.; Ang, Rebecca P.; Chua, Alina; Lam, Chee Meng

    2011-01-01

    We compared the effects of a 16-week Cognitive-Behavioral Therapy (CBT) program and a Social Recreational (SR) program on anxiety in children with Autism Spectrum Disorders (ASD). Seventy children (9-16 years old) were randomly assigned to either of the programs (n CBT = 36; n SR = 34). Measures on child's anxiety using the Spence Child Anxiety…

  10. 3D Analysis of Coupled Quasi-Stationary Electromagnetic and Non-Stationary Temperature Fields in Non-Magnetic Inductively Heated Charge

    Czech Academy of Sciences Publication Activity Database

    Barglik, J.; Doležel, Ivo; Šolín, Pavel; Ulrych, B.

    2001-01-01

    Roč. 97, č. 885 (2001), s. 9-16 ISSN 0072-4688 R&D Projects: GA ČR GA102/01/0184; GA MŠk ME 448 Grant - others:-(PL) 7T08603716 Keywords : induction heating * numerical analysis * integral model Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering

  11. Application of Markovian model to school enrolment projection ...

    African Journals Online (AJOL)

    Application of Markovian model to school enrolment projection process. VU Ekhosuehi, AA Osagiede. Abstract. No Abstract. Global Journal of Mathematical Sciences Vol. 5(1) 2006: 9-16. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT.

  12. Dolores Hoffmann pani Türi kiriku aknad särama / Marge Laagemann

    Index Scriptorium Estoniae

    Laagemann, Marge

    2005-01-01

    vitraažikunstnik räägib Türi kiriku vitraažidest, oma teekonnast vitraažide juurde, vitraažide valmistamisest, nende tekkest, ajaloost ning mõjust. Järgneb 2005. 9. dets., lk. 9, 16. dets., lk. 7, 23. dets., lk. 11 ja 30. dets., lk. 7

  13. Overview of fatigue behaviour of ultrafine-grained copper produced by severe plastic deformation

    Czech Academy of Sciences Publication Activity Database

    Lukáš, Petr; Kunz, Ludvík; Svoboda, Milan

    2008-01-01

    Roč. 567-568, - (2008), s. 9-16 ISSN 0255-5476. [MSMF /5./. Brno, 27.06.2007-29.06.2007] Institutional research plan: CEZ:AV0Z20410507 Keywords : Fatigue strength * Ultrafine-grained copper Subject RIV: BM - Solid Matter Physics ; Magnetism

  14. 78 FR 72931 - Sunshine Act Meeting Notice

    Science.gov (United States)

    2013-12-04

    ... 2, 9, 16, 23, 30, 2013, January 6, 2014. PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of December 2, 2013 There are no meetings scheduled for... Dry Casks (Public Meeting) (Contact: Kevin Witt, 301-415-2145). This meeting will be webcast live at...

  15. 77 FR 18271 - Notice of Sunshine Act Meeting

    Science.gov (United States)

    2012-03-27

    ... 26, April 2, 9, 16, 23, 30, 2012. PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of March 26, 2012 Tuesday, March 27, 2012 8:55 a.m... meeting will be webcast live at the Web address--www.nrc.gov. 9 a.m. Briefing on License Renewal for...

  16. Assessment of the stability of a surface crack in laminates

    Czech Academy of Sciences Publication Activity Database

    Hutař, Pavel; Ševčík, Martin; Náhlík, Luboš; Zouhar, Michal; Knésl, Zdeněk

    2014-01-01

    Roč. 50, č. 1 (2014), s. 9-16 ISSN 0191-5665 R&D Projects: GA ČR(CZ) GAP108/12/1560 Institutional support: RVO:68081723 Keywords : periodically layered composite * interface crack * generalized stress intensity factor * fracture mechanics of interface Subject RIV: JL - Materials Fatigue, Friction Mechanics Impact factor: 0.473, year: 2014

  17. Kinderen en internetrisico's

    NARCIS (Netherlands)

    Nathalie Sonck; Jos de Haan

    2011-01-01

    Internetgebruik brengt ook risico's met zich mee. Dit rapport behandelt het online risicogedrag van 9-16-jarigen in Nederland. Hoe vaak komen zij in aanraking met internetrisico's en hoe vaak ervaren zij dit zelf als vervelend? Typische internetrisico's zijn: online pestgedrag, het ontvangen

  18. President Ilves : Eesti ja maailma kõrgtehnoloogia firmade koostööl on tulevikku / Kaidi Aher

    Index Scriptorium Estoniae

    Aher, Kaidi

    2009-01-01

    President Toomas Hendrik Ilvese külaskäigust teadus- ja kõrgtehnoloogia keskusesse Silicon Valley'sse ning kohtumisest Stanfordi Ülikooli rektori John L. Hennessy'ga. Vabariigi President töövisiidil Ameerika Ühendriikides 9.-16.06.2009

  19. President Ilves töövisiidil USAs

    Index Scriptorium Estoniae

    2009-01-01

    President Toomas Hendrik Ilves alustas töövisiiti USA läänerannikul, teadus- ja kõrgtehnoloogia keskuses Silicon Valley's. Riigipea kohtus ka San Francisco linnapea Gavin Newsom'iga ja Stanfordi Ülikooli rektori John L. Hennessy'ga. Vabariigi President töövisiidil Ameerika Ühendriikides 9.-16.06.2009

  20. Nigerian Journal of Gastroenterology and Hepatology - Vol 4, No 1 ...

    African Journals Online (AJOL)

    Management of Liver Metastasis from Colo-Rectal Carcinoma with Laparoscopy: A Literature Review · EMAIL FULL TEXT EMAIL FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. E Ray-Offor, EF Alufohai, AB Allison, 9-16. Helicobacter Pylori: Serological Testing and Treatment in Uninvestigated Dyspepsia: ...

  1. Light Use Efficiency of Aboveground Biomass Production of Norway Spruce Stands

    Czech Academy of Sciences Publication Activity Database

    Bellan, Michal; Marková, I.; Zaika, A.; Krejza, Jan

    2017-01-01

    Roč. 65, č. 1 (2017), s. 9-16 ISSN 1211-8516 R&D Projects: GA TA ČR TA02010945 Institutional support: RVO:67179843 Keywords : absorbed photosynthetically active radiation * aboveground biomass increment * allometric relation Subject RIV: GC - Agronomy OBOR OECD: Agronomy, plant breeding and plant protection

  2. Precipitation conditions at the mountain study site of Bílý Kříž (the Beskids Mts.) during the past 20 years

    Czech Academy of Sciences Publication Activity Database

    Marková, I.; Janouš, Dalibor; Holata, Filip

    2017-01-01

    Roč. 10, 1-2 (2017), s. 9-16 ISSN 1803-2451 R&D Projects: GA MŠk(CZ) LO1415 Institutional support: RVO:86652079 Keywords : annual precipitation sum * precipitation intensity * drought period * Lang’s rain factor * standardized precipitation index Subject RIV: EH - Ecology, Behaviour OBOR OECD: Environmental sciences (social aspects to be 5.7)

  3. validity and reliability of the session rPe method for monitoring ...

    African Journals Online (AJOL)

    tifying exercise training intensities4,7,8,9,16,17,23 and as the intensity component of larger schemes of evaluating train- ... tive methods of measuring exercise training intensity, such as %VO2peak, %HRpeak, and %HRreserve; nor has ..... Recommendations for cardiovascular screening, staffing and emergency policies at ...

  4. Experiments on rocks under high pressure conditions in GTA 20-32 triaxial press

    Czech Academy of Sciences Publication Activity Database

    Poláček, J.; Kožušníková, Alena

    2012-01-01

    Roč. 58, č. 1 (2012), s. 9-16 ISSN 1802-5420 Institutional support: RVO:68145535 Keywords : triaxial stress * deformation * rocks Subject RIV: DH - Mining, incl. Coal Mining http://gse.vsb.cz/2012/LVIII-2012-1-09-16.pdf

  5. Experiment list: SRX326375 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NA 27184945,92.9,16.3,1037 GSM1191933: NPC Nup98-IgG ChIP-Seq; Homo sapiens; ChIP-Seq source_name=Neural progenitor cells, Nup98... ChIP || cell line=HUES6-derived || cell type=neural progenitor cells || chip antibody=Nup98

  6. march issue.cdr

    African Journals Online (AJOL)

    User

    suspicion and to thoroughly evaluate cases of stroke in individuals below age 45, especially in the absence of cardiovascular risk factors such as diabetes mellitus, hypertension or hyperlipidemia. 9,10. 5,6,9. 16,17,18. 17,18. 18. 18. 19. REFERENCE. 1. Kappelle IJ, Adas HP Jr, Heffner ML,. Torner JC, Gomez F, Biller J. 2.

  7. Brief Report: Influence of Physical Activity on Sleep Quality in Children with Autism

    Science.gov (United States)

    Wachob, David; Lorenzi, David G.

    2015-01-01

    Sleep-related problems are often documented in children with Autism Spectrum Disorders (ASD). This study examined physical activity as a variable that might influence sleep quality in children with ASD. Ten children, ages 9-16 years, were asked to wear accelerometer devices for 7 days in order to track objective measures of activity and sleep…

  8. Situational Awareness in Complex Systems

    Science.gov (United States)

    1994-01-31

    of situational awareness developed by Harwood, Barnett, and Wickens. These authors distilled four, primary parameters to describe a model of...A9.16 Eye" a tv* J Bette, Phght *Better CG omw Figue 3. "Agie Eye - a HUD-on-thehead witou penaltie to the pilot. "Agsk Eye" Payoff In A/A, there are

  9. 76 FR 57985 - Information Collection Being Reviewed by the Federal Communications Commission Under Delegated...

    Science.gov (United States)

    2011-09-19

    ... certain changes in the licensed facilities of these stations. Additionally, when changes are made to an AM station that alter the resistance of the antenna system, a licensee must initiate a determination of the... Secretary, Office of Managing Director. [FR Doc. 2011-23942 Filed 9-16-11; 8:45 am] BILLING CODE 6712-01-P ...

  10. Journal of Astrophysics and Astronomy | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... pp 9-16. Homotopy Continuation Method of Arbitrary Order of Convergence for Solving the Hyperbolic Form of Kepler's Equation · M. A. Sharaf M. A. Banajh A. A. Alshaary ... Evolution of the Distribution of Neutron Exposures in the Galaxy Disc: An Analytical Model · Wenyuan Cui Weijuan Zhang Bo Zhang.

  11. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    pp 9-16 Research Article. Genetic analysis of fertility restoration under CGMS system in rice (Oryza sativa L.) using three-way test-cross method · Philip Shalini Swaminathan Manonmani Sabariappan Robin · More Details Abstract Fulltext PDF. We studied the genetics of fertility restoration by producing three-way test cross ...

  12. Armastuse feng shui / Peeter Rüberg

    Index Scriptorium Estoniae

    Rüberg, Peeter

    2000-01-01

    Järg Jan/13;20;27/Feb/3;10;17;23/Mar/2;9;16 ;30/Apr/13/May/4;11 lk. 22;38;56;70;87;102;118;134;150;166;198;230;278 ;296Vanal hiina kodu- ja elukunstil on igaks armuelu juhtumiks varuks praktilisi nõuandeid ja võtteid

  13. 76 FR 69723 - Certain New Chemicals; Receipt and Status Information

    Science.gov (United States)

    2011-11-09

    ...- methoxyphenyl)- 0. P-11-0635 9/14/2011 12/12/2011 Dow Chemical (G) Reactant for (G) Toulene Company. production...) Reactant for (G) Toulene Company. production of diisocyanate polyurethane prepolymer. elastomers. P-11-0637...-11-0640 9/16/2011 12/14/2011 CBI (G) Adhesive and (G) Short fusion cleaning partner protein...

  14. Stability analysis of food barley genotypes in northern Ethiopia ...

    African Journals Online (AJOL)

    They accounted for 72.21, 9.16, and 4.47% of the total sum of squares, respectively. Large sum of squares indicated that the environments were diverse; causing most of the variation in grain yield. The multiplicative variance of the treatment sum of squares due to GEI was partitioned into the interaction principal component ...

  15. A retrospective analysis of thyroid disease in pregnancy at Chris ...

    African Journals Online (AJOL)

    A total of 58 pregnant women (66%) were hyperthyroid, 23 (26%) hypothyroid and 7 (8%) had euthyroid colloid goitres. Fortyeight (83%) hyperthyroid patients had Graves' disease, while 9 (16%) had gestational hyperthyroidism. Regarding the hypothyroid patients, more than half followed I-131 ablation for Graves' disease.

  16. 76 FR 58005 - Meeting Notice; Depository Library Council to the Public Printer

    Science.gov (United States)

    2011-09-19

    ... GOVERNMENT PRINTING OFFICE Meeting Notice; Depository Library Council to the Public Printer The Depository Library Council to the Public Printer (DLC) will meet on Monday, October 17, through Thursday..., Public Printer of the United States. [FR Doc. 2011-23948 Filed 9-16-11; 8:45 am] BILLING CODE 1520-01-P ...

  17. Prevalence of Intestinal Parasites in Primary School Children of ...

    African Journals Online (AJOL)

    Prevalence of Intestinal Parasites in Primary School Children of Mthatha, Eastern Cape Province, South Africa. ... The most common parasite was Ascaris lumbricoides 29.0% (47/162), followed by Giardia lamblia 9.9% (16/162) and Entamoeba histolytica/dispar 6.8% (11/162) (Other parasites observed but at lower rates of ...

  18. Eluviisi mõjust haigusele / Lilian Hankewitz

    Index Scriptorium Estoniae

    Hankewitz, Lilian

    2004-01-01

    Raamatu "Vähi vastu aitab see, kui me ei anna talle võimalust tekkidagi" autorid meditsiinidoktor Hari Sharma, ayurveda arst Rama Mishra ja dr. James Meade'i annavad nõu haigusvaenuliku pinnase loomises ja inimese organismi tugevdamises. Järgneb 19.,26. okt., 2., 9.,16.,23.,30. nov., 7.,14.,21. dets.

  19. Enhancement of Intranasal Vaccination in Mice with Deglycosylated Chain A Ricin by LTR72, a Novel Mucosal Adjuvant

    Science.gov (United States)

    2006-03-15

    in developing and applying adjuvants that can enhance mucosal immunity. Parenteral administration of aluminum (alum) hydroxide or phosphate (the... intramuscular immunization. Infect Immun 1999;67:4276–9. [16] O’Hagen DT, Rappuoli R. Novel delivery systems for intranasal immunization with inactivated

  20. Children and the risks of using the Internet

    NARCIS (Netherlands)

    Nathalie Sonck; Jos de Haan

    2011-01-01

    Original title: Kinderen en internetrisico's As well as benefits, Internet use carries risks. This report looks at the online risks to which 9-16 year-olds in the Netherlands expose themselves. How often do they come into contact with online risks and how often do they themselves find this

  1. Degradation of organophosphorus pesticide parathion methyl on nanostructured titania-iron mixed oxides

    Czech Academy of Sciences Publication Activity Database

    Henych, Jiří; Štengl, Václav; Slušná, Michaela; Matys Grygar, Tomáš; Janoš, P.; Kuráň, P.; Šťastný, M.

    2015-01-01

    Roč. 344, JUL (2015), s. 9-16 ISSN 0169-4332 R&D Projects: GA ČR(CZ) GAP106/12/1116 Institutional support: RVO:61388980 Keywords : Titania-iron oxides * Homogeneous hydrolysis * Degradation of organophosphates * Parathion methyl Subject RIV: CA - Inorganic Chemistry Impact factor: 3.150, year: 2015

  2. Nigerian Journal of Biotechnology - Vol 9, No 1 (1998)

    African Journals Online (AJOL)

    Effect of supplementation of soyabean diet with L-and D,L-methionine on the growth of mudfish Clarias anguillaris (L) fingerlings · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. AA Eyo, AA Olatunde, 9-16 ...

  3. On my ideas of the qualities of an ideal resident staff | Akintewe ...

    African Journals Online (AJOL)

    On my ideas of the qualities of an ideal resident staff. TA Akintewe. Abstract. No Abstract. Annals of Ibadan Postgraduate Medicine Vol. 4 (1) 2006: pp. 9-16. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.4314/aipm.v4i1.39054.

  4. Estonia President, Obama Discuss Cybersecurity / Eric Chabrow

    Index Scriptorium Estoniae

    Chabrow, Eric

    2009-01-01

    President Toomas Hendrik Ilves kohtus 15. juunil 2009 Washingtonis USA presidendi Barack Obamaga. Riigipead arutasid küberkaitse küsimusi. Eesti president avaldas Ühendriikidele tänu abi eest küberkaitsekeskuse loomisel Tallinnasse. Vabariigi President töövisiidil Ameerika Ühendriikides 9.-16.06.2009

  5. Assessment on major livestock health problems in southern zone of ...

    African Journals Online (AJOL)

    The most frequent diseases of cattle mentioned by the respondents include; blackleg (47.5%), anthrax (35%), pneumonic pasteurellosis (33.3%), ectoparasitism (11.7%) and foot and mouth disease (9.16%). In small ruminants the major health problems identified based on the respondents response were Peste des petits ...

  6. The effects of tree species and substrate on carbon sequestration and chemical and biological properties in reforested post-mining soils

    Czech Academy of Sciences Publication Activity Database

    Józefowska, A.; Pietrzykowski, M.; Woś, B.; Cajthaml, T.; Frouz, Jan

    2017-01-01

    Roč. 292, April (2017), s. 9-16 ISSN 0016-7061 Institutional support: RVO:60077344 Keywords : post mining soil * PLFA * bioturbation * C:N ratio * carbon stock * nitrogen stock Subject RIV: DF - Soil Science OBOR OECD: Soil science Impact factor: 4.036, year: 2016

  7. Prenatal diagnostic testing of the Noonan syndrome genes in fetuses with abnormal ultrasound findings

    NARCIS (Netherlands)

    Croonen, Ellen A.; Nillesen, Willy M.; Stuurman, Kyra E.; Oudesluijs, Gretel; van de Laar, Ingrid M. B. M.; Martens, Liesbeth; Ockeloen, Charlotte; Mathijssen, Inge B.; Schepens, Marga; Ruiterkamp-Versteeg, Martina; Scheffer, Hans; Faas, Brigitte H. W.; van der Burgt, Ineke; Yntema, Helger G.

    2013-01-01

    In recent studies on prenatal testing for Noonan syndrome (NS) in fetuses with an increased nuchal translucency (NT) and a normal karyotype, mutations have been reported in 9-16% of cases. In this study, DNA of 75 fetuses with a normal karyotype and abnormal ultrasound findings was tested in a

  8. Místní klimatické zóny a jejich význam ve městech České republiky

    Czech Academy of Sciences Publication Activity Database

    Lehnert, M.; Geletič, Jan

    2017-01-01

    Roč. 20, č. 2 (2017), s. 9-16 ISSN 1212-0855 Institutional support: RVO:86652079 Keywords : local climate zones * air temperature * urban heat island Subject RIV: DG - Athmosphere Sciences, Meteorology OBOR OECD: Climatic research http://www.uur.cz/images/5-publikacni-cinnost-a-knihovna/casopis/2017/2017-02/04-mistni.pdf

  9. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics. K. Kosalai. Articles written in Journal of Genetics. Volume 80 Issue 1 April 2001 pp 9-16. An automated annotation tool for genomic DNA sequences using GeneScan and BLAST · Andrew M. Lynn Chakresh Kumar Jain K. Kosalai Pranjan Barman Nupur Thakur Harish Batra Alok ...

  10. 78 FR 59663 - Combined Notice of Filings

    Science.gov (United States)

    2013-09-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal....m. ET 9/16/13. Docket Numbers: RP13-1331-000. Applicants: El Paso Marketing Company, L.L.C., Gazprom Marketing & Trading USA, Inc. Description: Joint Petition for Temporary Waivers of Commission Policies...

  11. The almost sure local central limit theorem for the product of partial ...

    Indian Academy of Sciences (India)

    8] extended (1.1) to the case that the underling distribution is in the domain of attraction of a stable law with exponent in [1, 2]. For more recent work on the weak convergence of the product of partial sums, see [6,9,16]. There are many papers ...

  12. African Journal of Biomedical Research - Vol 14, No 1 (2011)

    African Journals Online (AJOL)

    Distribution of mecA gene amongst Staphylococcus aureus isolates from Southwestern Nigeria · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. OA Terry Alli, DO Ogbolu, E Akorede, OM Onemu, BM Okanlawon, 9-16 ...

  13. EEG transients in the sigma range during non-REM sleep predict learning in dogs

    NARCIS (Netherlands)

    Iotchev, I.B.; Kis, A.; Bodizs, R.; Luijtelaar, E.L.J.M. van; Kubinyi, E.

    2017-01-01

    Sleep spindles are phasic bursts of thalamo-cortical activity, visible in the cortex as transient oscillations in the sigma range (usually defined in humans as 12-14 or 9-16 Hz). They have been associated with sleep-dependent memory consolidation and sleep stability in humans and rodents.

  14. Mid-infrared Spectroscopy of High-redshift 3CRR Sources

    NARCIS (Netherlands)

    Leipski, C.; Haas, M.; Willner, S. P.; Ashby, M. L. N.; Wilkes, B. J.; Fazio, G. G.; Antonucci, R.; Barthel, P.; Chini, R.; Siebenmorgen, R.; Ogle, P.; Heymann, F.

    2010-01-01

    Using the Spitzer Space Telescope, we have obtained rest-frame 9-16 mu m spectra of 11 quasars and 9 radio galaxies from the 3CRR catalog at redshifts 1.0

  15. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    oxadiazole. Abstract. Derivatives of 1,3-thiazolidin-2,4-dione appended to biphenyl ring viz., 7-9, 16-18 were prepared. The newly synthesized compounds were confirmed by IR, NMR (1H and 13C) MS and elemental analyses. Single crystal X-ray ...

  16. Single-flavor color superconductivity with color-sextet pairing

    Czech Academy of Sciences Publication Activity Database

    Brauner, Tomáš

    2005-01-01

    Roč. 55, č. 1 (2005), s. 9-16 ISSN 0011-4626 R&D Projects: GA ČR(CZ) GA202/02/0847 Keywords : color superconductivity * spontaneous symmetry breaking Subject RIV: BE - Theoretical Physics Impact factor: 0.360, year: 2005

  17. Prevalence of mandibular and palatine tori among the Ibos in Enugu ...

    African Journals Online (AJOL)

    2015-08-12

    Aug 12, 2015 ... Torus palatinus and torus mandibularis in edentulous patients. J Contemp Dent Pract 2006;7:112‑9. 16. Agbaje JO, Arowojolu MO, Kolude B, Lawoyin JO. Torus palatinus and torus mandibularis in a Nigerian population. Afri J Oral Health 2005;2:30‑6. 17. Adeyemo WL, Emeka CI, Taiwo OA, Adeyemi MO.

  18. WRITINGS RELATED WITH CORONARY ARTERY DISEASE AND RISK FACTORS WHICH WERE PRINTED IN TEN NATIONAL DAILY NEWSPAPER

    Directory of Open Access Journals (Sweden)

    Hakan ALTINTAS

    2005-10-01

    Full Text Available This study is a descriptive epidemiological study which was conducted in order to determine various properties of writings related to coronary artery disease (CAD and its risk factors in 10 top selling national newspapers based on newspaper listing. Most of the writings related to CAD and its risk factors composed less than 0.20%of total surface area of a newspaper. In 21.9%(16 of such writings, there were no pictures, and presentation techniques were not effective. When evaluated for scientific truth, 21.9%(16 of the writings were composed of false or partialy true writings. It was realized that newspapers under investigation did not spare enough space for writings related to CAD and its risk factors. [TAF Prev Med Bull 2005; 4(5.000: 253-264

  19. Bone density assessment for evaluation of gender differences in cervical vertebral maturation: A computed tomography study

    Directory of Open Access Journals (Sweden)

    K Usha

    2016-01-01

    Full Text Available Introduction: The cervical vertebral maturation (CVM method is a vital tool for assessing the biological maturation of the orthodontic patient to evaluate the amount of mandibular bone growth left. Aim: To assess and visualize the cervical vertebral morphology (bone density of orthodontic patients of the age group 9,16,27 years. Material and Methods: Twenty four subjects with age group of 9,16,27 who were randomly selected and subjected to 3d tomographic study to estimate the biological age of the orthodontic patients by analyzing c1 c2 and c3 vertebrae. Result: The results showed that bone density of males is lesser than females in 9 and 16 years, whereas they have more bone density than females in 27 years. Conclusion: The study provides qualitative method of assessing the biological age of the patient by using images of cervical vertebrae by three dimensional approach. Hence it can be useful for orthodontic diagnosis and treatment plan.

  20. Bone density assessment for evaluation of gender differences in cervical vertebral maturation: A computed tomography study.

    Science.gov (United States)

    Usha, K; Baskaranarayanan, Balashanmugam; Nagarajan, D; Selvarani, R; Vijjaykanth, M

    2016-10-01

    The cervical vertebral maturation (CVM) method is a vital tool for assessing the biological maturation of the orthodontic patient to evaluate the amount of mandibular bone growth left. To assess and visualize the cervical vertebral morphology (bone density) of orthodontic patients of the age group 9,16,27 years. Twenty four subjects with age group of 9,16,27 who were randomly selected and subjected to 3d tomographic study to estimate the biological age of the orthodontic patients by analyzing c1 c2 and c3 vertebrae. The results showed that bone density of males is lesser than females in 9 and 16 years, whereas they have more bone density than females in 27 years. The study provides qualitative method of assessing the biological age of the patient by using images of cervical vertebrae by three dimensional approach. Hence it can be useful for orthodontic diagnosis and treatment plan.

  1. "Estonia" müsteerium / Jüri Liim

    Index Scriptorium Estoniae

    Liim, Jüri

    2001-01-01

    Järgneb 26. okt., 2.,9.,16.,23.,30. nov., 7.,14. dets. ; 2002, 4.,11.,18.,25. jaan., 1.,8.,15.,22. veebr., 1.,8.,15.,22. märts, 5.,12.,26. aprill, 3.,10.,17.,24.,31. mai, 7.,14.,28. juuni, 5.,12.,19.,26. juuli, 2.,9.,16.,23. aug., 6.,13.,20.,27. sept., 4.,11.,25. okt., 1.,8.,15.,22.,29. nov., 13.,20. dets. ; 10.,17.,24., 31. jaan., 2003, 14. veebr., 7.,28. märts, 4.,11.,25. apr., 16.,23. mai, 6.,27. juuni, 11.,18. juuli. Reisilaev "Estonia" mõistatuslikust hukust

  2. Determination of Coefficient of Convection Heat Transfer at Continual Induction Hardening of Axi-Symmetric Bodies

    Czech Academy of Sciences Publication Activity Database

    Barglik, J.; Doležel, Ivo; Ulrych, B.

    2003-01-01

    Roč. 928, č. 101 (2003), s. 9-16 ISSN 0374-4817 R&D Projects: GA ČR GA102/01/0184; GA MŠk ME 542 Grant - others:PSRC(PL) 4T08C 04823 Institutional research plan: CEZ:AV0Z2057903 Keywords : convective heat transfer coefficient * numerical modelling * induction hardening Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering

  3. Nädal Riigikogus / Ramon Loik

    Index Scriptorium Estoniae

    Loik, Ramon

    2003-01-01

    Järg 7.,14.,21. mai, 4.,11.,18. juuni, 24.september, 1.,15.,22.,29. oktoober, 12.,19.,26. november, 10.,17.,24. detsember, 5.,21.,28. jaanuar 2004. a., 4.,18., 25. veebruar, 3.,17.,24. märts, 21., 28. aprill, 12., 19., 26. mai, 9.,16. juuni, 22.,29. sept. lk. 5. Riigikogu töö tutvustus

  4. Risk factors, pre-presentation management and clinical state of ...

    African Journals Online (AJOL)

    Most of the children (35 or 64.82%) first presented at Patent Medicine Stores and 38 or 70.37% had some oral fluids. While 9 (16.67%) had dysentery 31(57.41) had anti-microbials and 18 (33.33%) had anti-emetics. Twelve (33.33%) of the children had severe dehydration and 2(3.70%) had extrapyramidal crisis from use of ...

  5. Medical Surveillance Monthly Report (MSMR). Volume 14, Number 4, July 2007

    Science.gov (United States)

    2007-07-01

    pregnancy. Mil Med. 2007 Jan;172(1):9- 16. 12. Lei Z-W, Wu SC, Garceau RJ, et al. Effect of pretreatment counseling on discontinuation rates in...publications/ mec / 14 VOL. 14 / NO. 4 • JULY 2007 0 10,000 20,000 30,000 40,000 50,000 60,000 70,000 80,000 90,000 100,000 110,000 120,000 J an ua ry

  6. Defence Nutrition Workshop, April 2006, Proceedings

    Science.gov (United States)

    2007-05-01

    ischaemic heart disease death and a 9%, 16% and 2% reduction of incidence for stroke , type 2 diabetes and colon cancer respectively. These risk...benefits in the prevention of lifestyle diseases such as heart disease , stroke , type 2 diabetes and some cancers. There were significant improvements...immediate health threats such as gastrointestinal infections, and also against long-term health threats such as increased risk of disease through the

  7. An Alaskan Theater Airlift Model.

    Science.gov (United States)

    1982-02-19

    Fairbanks area capable of dealing with the problem, the aircraft comander and the 2S -I... engineer decide that the leaking oil line will permit safe...Wainwright, the pilot advises the Elemndorf comand post of the maintenanoc problem and his intentions; the oontroller at Elmendorf agrees with the plan...M9(16) controls MITACE and other embedded print statements which serve to trace aircraft and mission K.entities through the network. X1(98) set to I

  8. Advanced Relay Design and Technology for Energy-Efficient Electronics

    Science.gov (United States)

    2011-07-07

    minimized by properly tuning material deposition conditions. The hinge material of the Texas Instruments Digital Mirror Display devices -- the...Estimates and Unique Failure Mechanisms of the Digital Micromirror Device (DMD),” in Proceedings of the IEEE Annual International Reliability Physics...Symposium (IRPS 󈨦), pp. 9-16, March 1998. [18] A. B. Sontheimer, “Digital Micromirror Device (DMD) Hinge Memory Lifetime Reliability Modeling,” in

  9. Aspects epidémiologiques des accidents domestiques de l'enfant à ...

    African Journals Online (AJOL)

    2. Clinics in Mother and Child Health. Tableau 1: Types d'accidents domestiques retrouvés. Type d'accident. Nombre. Pourcentage. Chute. 26. 46,4. Intoxication au pétrole. 9. 16,1. Brûlure. 5. 8,9. Coupure. 5. 8,9. Corps étranger. 4. 7,1. Collusion avec un objet contondant. 4. 7,1. Morsure. 2. 3,7. Suffocation. 1. 1,8. Total. 56.

  10. Characterization and Targeting of the Aldehyde Dehydrogenase Subpopulation in Ovarian Cancer

    Science.gov (United States)

    2016-10-01

    Hanks’ balanced salt solution (HBSS; Gibco) and injected intraperitoneally into NOD- SCIDmice in limiting dilutions . Mice were followed for 1 year or...malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res 2009;69:3382–9. 16. Carpentino JE, HynesMJ...peroxidase activity was quenched with 3% hydrogen peroxide solution in methanol for 15 minutes. Sections were blocked with CytoQ immune diluent and

  11. Cyberbullying experiences on-the-go: when social media can become distressing

    OpenAIRE

    Görzig, Anke; Frumkin, Lara A.

    2013-01-01

    The current study examines the differences between those who have been cyberbullied online and on mobile devices (on-the-go) and those who have been cyberbullied online but not on mobile devices. Additionally, country differences in cyberbullying on-the-go are explored. Analyses were carried out employing a random stratified sample of 25,142 children aged 9-16 from 25 European countries. A multilevel stepwise logistic regression with cyberbullying mode (online and mobile phone vs. online only...

  12. 76 FR 75786 - International Product and Price Changes

    Science.gov (United States)

    2011-12-05

    ... Depending on country destination and mail type, customers may continue to add a variety of extra services to...\\1/4\\'' x 6\\1/4\\'' x 9\\9/16\\'' x 6\\7/16\\'' x O-1096-L Video Box. 2''. 2\\3/16\\''. * * * * * [Renumber...''. Priority Mail International Board Game 23\\11/16\\'' x 11\\3/4\\'' 24\\1/16\\'' x 11\\7/8\\'' x GBFRB Large Flat...

  13. Who is Distressed Applying the Diabetes Related Distress Scale in a Diabetes Clinic

    Science.gov (United States)

    2017-06-09

    59 MDW /SGVU SUBJECT: Professional Presentation Approval 7APR 2017 1. Your paper, entitled Who is Distressed? Applying the Diabetes -Related Distress...Scale in A Diabetes Clinic presented at/published to American Diabetes Association 2017 Meeting, San Francisco, CA (National Conference), 9-16 June...as a publication/presentation, a new 59 MOW Form 3039 must be submitted for review and approval.) Using the Diabetes -Related Distress Scale in

  14. adaptation of introduced mungbean genotypes in uganda abstract ...

    African Journals Online (AJOL)

    ACSS

    African Crop Science Journal, Vol. 24, No. 2, pp. 155 - 166 ... African Crop Science Journal by African Crop Science Society is licensed under a Creative ..... 29.7. Season A rainfall (mm). 391. 547. 573. 359. 540. 598. Season B Temp in oC (min) 17.9. 17.4. 16.9. 16.8. 162.2. 17.6. Season B Temp in oC (max) 29.8. 29.7. 29.2.

  15. e-criminals are rearing their heads: who owns your computer? / Toivo Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Toivo

    2009-01-01

    Küberkuritegevusest. Rahvusvahelise arvutiturbefirma Trend Micro andmetel juhib Tartu firma Rove Digital üleilmset küberkuritegevuse võrgustikku. Küberrünnakutest Eesti vastu 2007. aasta kevadel. Tabelid. Diagrammid. President Toomas Hendrik Ilvese külaskäigust teadus- ja kõrgtehnoloogia keskusesse Silicon Valley'sse. Vabariigi President töövisiidil Ameerika Ühendriikides 9.-16.06.2009

  16. Plasma 25-Hydroxyvitamin D and Risk of Non-Melanoma and Melanoma Skin Cancer

    DEFF Research Database (Denmark)

    Afzal, Shoaib; Nordestgaard, Børge G; Bojesen, Stig E

    2013-01-01

    with increasing cumulative incidence of non-melanoma skin cancer (trend P=2 × 10(-15) and P=3 × 10(-17)) and melanoma skin cancer (P=0.003 and P=0.001). Multivariable adjusted hazard ratios of non-melanoma skin cancer were 5.04 (95% confidence interval (CI): 2.78-9.16) for 25-OH-vitD 50 vs. 60 years, 25-OH...

  17. Organizational Development: An Available Management Strategy

    Science.gov (United States)

    1976-11-21

    Roethlisberger, p. 186. 14. Rush, p. 11. 15. Richard Beckhard , Organizational Development: Strategies and Models, p. 9. 16. Robert R. Blake and Jane S. Mouton...Military Personnel Center, Washington, 15 July 1976. A 2 L-L I I1 Ic • I t "A .4 4, SELECTED BIBLIOGRAPHY 1. Beckhard , Richard . Organizational...those 9 organizational units that ask for OD intervention. Beckhard includes in his primary definition of OD the stipulation that the effort must be

  18. Thermal Stress

    Science.gov (United States)

    2011-01-01

    and Science in Sports and Exercise 37: 1328--1334. Coris EE, Ramirez AM, and Van Durme DJ (2004) Heat illness in athletes : The dangerous combination...of heat, humidity and exercise. Sports Medicine 34: 9--16. Gordon CJ and Leon LR (2005) Thermal stress and the physiological response to environmental...code) 2011 Book Chapter-Enc. of Environmental Health Thermal Stress L.R. Leon, C.J. Gordon Thermal and Mountain Medicine Division U.S. Research

  19. The Combined Effects of Radio Frequency and Gamma Irradiation on P-Channel MOSFETS

    Science.gov (United States)

    2010-09-01

    voltage.............................................. 34 18. Gamma cell at the OSU research reactor complex...37 19. Dose curve for gamma irradiation cell at OSU’s research reactor facility .................. 38 20. Pre-characterization...maximum width will eventually be reached and is described by: 2 ln 2 A s i m A NkT n W q N ε      = . (9) 16 Precise control of the

  20. Non-Invasive Cell-Based Therapy for Traumatic Optic Neuropathy

    Science.gov (United States)

    2015-06-01

    human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ Res, 2003. 92(6): p. 692-9. 16. Kawaguchi...Sinai Regenerative Medicine Institute, LA , CA 2006 - 2011 Assistant Professor, Casey Eye Institute, OHSU, Portland, USA 2005- 2006 Assistant...Transplantation of human central nervous system stem cells: Neuroprotection in retinal degeneration. Euro J Neurosci 2012:35: 468-77. Adamus Grazyna, Wang

  1. Determination of the antiproton-to-electron mass ratio by precision laser spectroscopy of $\\overline{p}He^{+}$

    CERN Document Server

    Hori, M; Eades, John; Gomikawa, K; Hayano, R S; Ono, N; Pirkl, Werner; Widmann, E; Torii, H A; Juhász, B; Barna, D; Horváth, D

    2006-01-01

    A femtosecond optical frequency comb and continuous-wave pulse- amplified laser were used to measure 12 transition frequencies of antiprotonic helium to fractional precisions of (9-16) 10/sup -9lifetimes hitherto unaccessible to our precision laser spectroscopy method. Comparisons with three-body QED calculations yielded an antiproton-to-electron mass ratio of M/sub pmacron//m/sub e/=1836.152 674(5).

  2. A Study of the Nature and Origins of Pyroelectricity and Piezoelectricity in Polyvinylidenefluoride and Its Co-Polymers.

    Science.gov (United States)

    1980-01-01

    iii) U! EXPERIMENTAL FINDINGS 2. Structure and Morphology of Films 2.1 Unstretched Films 50sm thick rolls of PVF2 from the Kureha Chemical Co. Ltd. of...and Form 2 Films Kureha 9, 16 and 25pm thick films were all biaxially oriented and contained both Form 1 and Form 2 crystallites, although the...Films The poling characteristics of Kureha films have been widely reported and this work has been concentrated on comparing increases in

  3. Subscriptions

    African Journals Online (AJOL)

    ₤36.30 less 10% to Subscription Agent (₤32.67 + ₤9.33 Forex charges = ₤42.00 to ISEA, Rhodes University). $57.48 less 10% to Subscription Agent ($51.73 + $18.27 Forex charges = $70.00 to ISEA, Rhodes University). Airmail: Please add a further £9/$16. Africa: Individuals: R230.00 less 10% to Agent - (R 207.00 incl.

  4. Surveillance Using Multiple Unmanned Aerial Vehicles

    Science.gov (United States)

    2009-03-01

    AFIT’s re- search began in 2006 with the work of Nidal Jodeh [8] modelling a 9.16 foot wingspan radio controlled model airplane, the Sig Rascal ...retrofitted with an autopilot. The stability and payload capacity of this airframe made it ideal for UAV research. Since the Sig Rascal became the primary...control surfaces were a V-tail with no ailerons vs. the traditional aileron/rudder/elevator configuration. The old Sig Rascal 2 model no longer applied. By

  5. International Disability Educational Alliance (IDEAnet)

    Science.gov (United States)

    2011-12-01

    informed policymaking.” Updated September 17, 2010. Accessed online: 9/16/2011 - http://www.indiainfoline.com/ Markets /News/Global-disparity-in...the Colombian Telemedicine Center. Dr. Velez suggested expansion of the iCons in Medicine program into Colombia , and identified a group of hospitals...Service Clubs (Rotary, Lions, Elks) •Exchange Programs •Faith Communities •Global Philanthropists/Foundations •Multinational Health, Pharmaceutical

  6. The Air Staff of Tomorrow: Smarter, Faster, Better

    Science.gov (United States)

    2009-02-12

    Kurzweil, The Singularity is Near, 8-9. 16 Humanity has already passed the threshold of bio-tech interfaces. Cochlear implants allow some deaf people to...information if it does not display a currently valid OMB control number. 1. REPORT DATE FEB 2009 2. REPORT TYPE N/A 3. DATES COVERED - 4...organic structures and processes. 2 David S. Alberts and Richard E. Hayes, Power to the Edge: Command...Control...In the Information Age

  7. Age-dependent differences in cytokine and antibody responses after experimental RSV infection in a bovine model

    DEFF Research Database (Denmark)

    Grell, S.N.; Riber, Ulla; Tjørnehøj, Kirsten

    2005-01-01

    Respiratory syncytial virus (RSV) causes severe respiratory disease in both infants and calves. As in humans, bovine RSV (BRSV) infections are most severe in the first 6 months of life. In this study, experimental infection with BRSV was performed in calves aged 1-5, 9-16 or 32-37 weeks. Compared...... "inflammatory" but weak humoral antiviral response in very young animals suggests that enhanced inflammation contributes to disease during RSV infection during the early postnatal period....

  8. Experiment list: SRX246860 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available SRX246860 hg19 TFs and others MBD3 Breast MCF-7 Primary Tissue=Breast|Site of Extra...ction=Pleura|Tissue Diagnosis=Adenocarcinoma 70619440,92.9,16.3,947 GSM1089817: MCF-7 MBD3; Homo sapiens; ChIP-Seq source_name=MCF-7..._MBD3 || cell line=MCF-7 || antibody=anti-MBD3 antibody (Abcam; ab91458) http://dbar

  9. The Influence of Modern Adolescents' Vision of Life on Their Perception of Art

    Science.gov (United States)

    Torshilova, Elena M.; Polosukhina, Irina A.

    2016-01-01

    During The aim of the multi-year study, conducted by the authors of present article, is to reveal the characteristics of social-cultural portrait of 9-16-year-old children, who grow up in the XXI century, along with the influence of modern children's vision of life on their perception of art. In order to solve the problem, the authors used the…

  10. American Burn Association Consensus Statements

    Science.gov (United States)

    2013-08-01

    renal replacement therapy in the patient with acute kidney injury. 3. Effect of inhalation injury, intubation and mechanical ventilation, opioids...benefits of other nutrients is lacking. Glutamine has several valuable functions that may be beneficial to burn patients . Evidence among adult burn...on clinical out- come in ICU patients . Clin Nutr 2005;24:502–9. 16. Moran L, Custer P, Murphy G. Nutritional assessment of lean body mass. J Parenter

  11. Some Comments on the Endochronic Theory of Plasticity.

    Science.gov (United States)

    1979-10-01

    theorem is valid when a = 1 , it is valid for all a It is suggested that an experimental test of the validity or non-validity of the constitutive... pCp )] 2 13 = det[dEp(Cp)]. (9.15) which is homogeneous of degree unity in dp . We take = 0 when e = 0 . We define Z by Z = (Lp) . (9.16) With this new

  12. Hyaluronidase inhibitors from "Cimicifugae Rhizoma" (a mixture of the rhizomes of Cimicifuga dahurica and C. heracleifolia).

    Science.gov (United States)

    Iwanaga, Atsufumi; Kusano, Genjiro; Warashina, Tsutomu; Miyase, Toshio

    2010-04-23

    From the 80% acetone extract of "Cimicifugae Rhizoma" (a mixture of Cimicifuga dahurica and C. heracleifolia used medicinally), seven new fukiic acid derivatives (1-7) and a new phenylethanoid derivative (8) were isolated along with eight known compounds (9-16). Fukinolic acid (9) and cimicifugic acids A-J (10-16, 5-7) showed stronger hyaluronidase inhibitory activities than the positive control, rosmarinic acid.

  13. Leveraging Crystal Anisotropy for Deterministic Growth of InAs Quantum Dots with Narrow Optical Linewidths

    Science.gov (United States)

    2013-08-29

    organic chemical vapor deposition ( MOCVD ) growth on (111)B substrates without self-assembly.9,16 Despite the considerable promise of using prepatterned...burden for the collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing...data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden

  14. Characterization of Chromatin Structure-associated Histone Modifications in Breast Cancer Cells

    Directory of Open Access Journals (Sweden)

    Chang Pyo Hong

    2012-09-01

    Full Text Available Chromatin structure and dynamics that are influenced by epigenetic marks, such as histone modification and DNA methylation, play a crucial role in modulating gene transcription. To understand the relationship between histone modifications and regulatory elements in breast cancer cells, we compared our chromatin immunoprecipitation sequencing (ChIP-Seq histone modification patterns for histone H3K4me1, H3K4me3, H3K9/16ac, and H3K27me3 in MCF-7 cells with publicly available formaldehyde-assisted isolation of regulatory elements (FAIRE-chip signals in human chromosomes 8, 11, and 12, identified by a method called FAIRE. Active regulatory elements defined by FAIRE were highly associated with active histone modifications, like H3K4me3 and H3K9/16ac, especially near transcription start sites. The H3K9/16ac-enriched genes that overlapped with FAIRE signals (FAIRE-H3K9/14ac were moderately correlated with gene expression levels. We also identified functional sequence motifs at H3K4me1-enriched FAIRE sites upstream of putative promoters, suggesting that regulatory elements could be associated with H3K4me1 to be regarded as distal regulatory elements. Our results might provide an insight into epigenetic regulatory mechanisms explaining the association of histone modifications with open chromatin structure in breast cancer cells.

  15. Perturbations to the Lower Ionosphere by Tropical Cyclone Evan in the South Pacific Region

    DEFF Research Database (Denmark)

    Kumar, Sushil; Amor, Samir Nait; Chanrion, Olivier

    2017-01-01

    ) observed during tropical cyclone (TC) Evan, 9-16 December 2012 when TC was in the proximity of the transmitter-receiver links. We observed a maximum amplitude perturbation of 5.7dB on JJI transmitter during 16 December event. From Long Wave Propagation Capability model applied to three selected events we...... and sink (bringing the lower ionosphere with it), an effect that may be mediated by gravity waves generated by the TC. The perturbations were observed before the storm was classified as a TC, at a time when it was a tropical depression, suggesting the broader conclusion that severe convective storms...

  16. Study of wind change for the development of loads reduction techniques for the space shuttle

    Science.gov (United States)

    Adelfang, S. I.

    1987-01-01

    Wind change statistics are analyzed for Vandenberg AFB, California (VAFB) and Kennedy Space Center, Florida (KSC). Means and standard deviations of wind component change and vector wind change modulus within 3-9 and 9-16 km altitude bands are tabulated. The contribution to 3.5 hr wind component change by wind perturbations in various wavelength bands is evaluated. Probability distributions of maximum 3.5 hr wind change in an altitude band are presented and a model for wind change at a specified altitude is tested with data derived from six data bases from VAFB and Santa Monica, California.

  17. Improvements to Fuze Test Methods and Equipment and Development of New Monitoring Techniques for (MIL-STD-331)

    Science.gov (United States)

    1975-10-01

    217TS TELECOMPUTER L TWO-STEEL DOWEL PIN 1180 X I. l.G. TW0-1/4-20 WING NUT THREE-KNURLED HEAD SWIVEL SCR VUER FMT NO. N6565 THREE -1/4-20, 9/16...3 !;;,JI!;Y=---l-------n•.u:-1/4-20, 1/4 LG SET SCR (CUP PT) ( #10-32 UNF-28 CD ADAPTER ONE-STEEL FS 1035 AS COLD-FINISHED BLACK OXIDE 2..750...1 Jolt and 1 Jumble). Snythetic materials (nylon, polyurethane, teflon and poly- ethylene ) were obtained for possible replacement of the natural

  18. The primary haemostasis is more preserved in thrombocytopenic patients with liver cirrhosis than cancer

    DEFF Research Database (Denmark)

    Vinholt, Pernille Just; Alnor, Anne B; Nybo, Mads

    2018-01-01

    : In thrombocytopenia, differences in haemostatic capacity may explain discrepancies in bleeding risk between patients with cancer and patients with liver cirrhosis. The objective was to compare the haemostatic capacity in different thrombocytopenic patient populations. We evaluated platelet aggr....... Fibrinogen activity was higher in patients with cancer compared with patients with cirrhosis [12.5 μmol/L (IQR 9.9-16.5) versus 7.2 μmol/l (IQR 5.6-10.2)], P preserved primary haemostasis compared with patients with cancer....

  19. Dokumente küüditajatelt

    Index Scriptorium Estoniae

    2008-01-01

    Ajakirjas on avaldatud küüditajate raportid 1941. aasta küüditamisel valitsenud meeleolude kohta: "[EK(b)P Valgamaa Komitee] aruanne EK(b)P KK sekretär sms. Särele" (16. juuni 1941.a) ; "Väljavõte EK(b)P Valgamaa Komitee informatsioonist EK(b)P Keskomiteele ajavahemikust 8.-14. juunini 1941. a." (17. juuni 1941. a) ; "Väljavõte EK(b)P Tartumaa Komitee nädalainformatsioonist EK(b)P Keskkomiteele 9.-16. juunini 1941. a." (17. juuni 1941. a.)

  20. Work Plan for an Inpatient Rehabilitation Prospective Payment System

    Science.gov (United States)

    2000-01-01

    brain injury or spinal cord injury 14.9 18 Miscellaneous 11,12.1,12.9,13,15,16,17 through 17.9 19 Guillian Barre 3.4 20 Major multiple trauma, with...Osteoarfhritis 6.2 13 Rheumatoid, other arthritis 6.1,6.9 14 Cardiac 9 15 Pulmonary 10.1,10.9 16 Pain Syndrome 7.1 through 7.9 17 Major multiple trauma, no...CYSTIC FIBROSIS W ILEUS CONG FACTOR VHIDIORD CONG FACTOR TX DISORDER DEFIBRTNATION SYNDROME HEMOPHTLUS MENTNGITIS PNEUMOCOCCAL MENTNGITIS

  1. Densidad de siembra y fertilización nitrogenada en trigo : 1-cultivares Marcos Juárez INTA y Norkinpan 70

    OpenAIRE

    Lerner, Silvia Elena; Mac Maney, Miguel; Tapia, M. R.

    1986-01-01

    p.9-16 Se presenta en este trabajo la respuesta de dos cultivares de trigo de ciclo corto, ante variaciones en la densidad de siembra y en nutrición nitrogenada. Se utilizaron dos densidades de siembra (300 y 600 pl-m2) y una fertilización con urea a mediados de macollaje (150 kg-ha). En momentos preestablecidos del ciclo del cultivo se realizaron cortes para medición de biomasa, área foliar y componentes del rendimiento: espigas por metro cuadrado, granos por espiga y peso de los granos. ...

  2. Magnetic fabric of Red Beds from the Conraria Formation, Central Portugal

    OpenAIRE

    Gomes, C. R.; Sant'Ovaia, H.; Rocha, A. F.; Soares, A. F.

    2010-01-01

    Poster apresentado ao VIII Congresso Nacional de Geologia, em Braga (9-16 de Julho 2010) O objectivo principal deste estudo consistiu em quantificar o fabric magnético em amostras da subunidade superior da Formação de Conraria, Grupo de Silves, na região de Coimbra. Foram efectuadas determinações de anisotropia da susceptibilidade magnética (ASM) em 50 amostras, obtidas em 11 sites, de forma a caracterizar o seu fabric magnético. O paralelismo geral entre um fabric achatado e a ...

  3. Measuring and Analyzing Cognitive Skills at the Platoon Level

    Science.gov (United States)

    1990-03-01

    the time the fourth decision must be made. Keeping track of that many alternatives quickly becomes un - manageable. It is possible to make the decisions...1.3 2.2 1.4 2.0 ,v Time to Complete 2M.3 20.9 16.3 IS.3 21.0 First Test (. un )_ Number Tested First Test 3 7 4 9 6 Nunber Tested Second 3 6 4 7 5 Test...RESIDUALS ~ESIDUALS NORMAL PROBABILITY PLOT, N-29 ANALISIS OF NORMAL DISTRIBOTION PIT -- - - - -- -- - --- - -- - -- - - - -- - - - - DATA SELECTION

  4. Taasiseseisvumiseelne Rapla / Tõnis Tõnisson

    Index Scriptorium Estoniae

    Tõnisson, Tõnis, 1945-

    2002-01-01

    Järg 8.,10.,15.,17.,22.,24.,29.,31. jaanuar ; 5.,7.,12.,14.,21.,26.,28. veebruar ; 5.,7.,12.,14.,19.,21.,26. märts ; 2.,4.,9.,16.,18.,23.,25. aprill ; 7.,9.,14.,16.,21.,23.,28.,30. mai ; 4.,6.,11.,13.,18.,20.,27. juuni ; 2.,4.,9.,11.,16.,18.,23.,25.,30. juuli ; 1.,6.,8.,13.,15., 22.,24.,27.,29. august ; 3.,10.,12.,17. september. Algus: 26. juuli 2001. Sündmustest Raplamaal aastatel 1988-1991

  5. Evaluation and Computational Characterization of the Faciliated Transport of Glc Carbon C-1 Oxime Reactivators Across a Blood Brain Barrier Model

    Science.gov (United States)

    2013-01-01

    and 18 mM. Samples were collected after 2 h. For the mM oxime tests cell lysates were prepared. Lucifer yellow and trans epithelial electric resistance...quaternary pralidox- ime derivatives [9,16,17,25], and 13c is the most effective SOx reactivator to date (Table 1). We developed and validated molecu- lar...and explain the apparent CNS effects of SOx; or, there is some other as yet uniden- tified mechanism for SOx BBB penetration that may not primarily

  6. 1st February 2011-CERN Cultural Board for Engaging with the Arts, visiting CMS experimental area and LHC Tunnel at Point 5

    CERN Multimedia

    Michael Hoch

    2011-01-01

    Photo 1-4: Visit to CMS Control Room with G. Tonelli,CMS Collaboration Spokesperson Photo 5-9,16-20:CMS experimental area Photo 10-15:LHC Tunnel at Point 5 Photo 21:F. Madlener,Director of IRCAM Paris+S. Dorny,Director-General Lyon Opera House+C. Bollman,Art by Genève+M. Doser,AEgIS Collaboration Spokesperson,Former Physics Department Deputy Head+A. Koek,International Arts Development+G. Tonelli+M. Monje Cano,Arts Development Assistant (part-time work experience)+B. Ruf,Director of Kunsthalle Zürich

  7. Incumbency in Multi-level Political Systems and Recruitment Advantage: The Case of the Czech Regional Assemblies

    Czech Academy of Sciences Publication Activity Database

    Bernard, Josef; Šafr, Jiří

    2016-01-01

    Roč. 52, č. 3 (2016), s. 267-291 ISSN 0038-0288 R&D Projects: GA ČR GAP404/12/0714 Institutional support: RVO:68378025 Keywords : incumbency * legislative recruitment * multi-level political system Subject RIV: AD - Politology ; Political Sciences Impact factor: 0.143, year: 2016 http://sreview.soc.cas.cz/uploads/6184b97b7357aa4e289089fff7852b7d898290d9_16-3-02Bernard15.indd.pdf

  8. Interpretation and mathematical modeling of temporal changes of temperature observed in borehole Yaxcopoil-1 within the Chicxulub impact structure, Mexico

    Czech Academy of Sciences Publication Activity Database

    Šafanda, Jan; Wilhelm, H.; Heidinger, P.; Čermák, Vladimír

    2009-01-01

    Roč. 372, č. 1-4 (2009), s. 9-16 ISSN 0022-1694 R&D Projects: GA ČR(CZ) GA205/06/1181 Grant - others:Deutsche Forschungsgemeinschaft(DE) W1 687/17-1,2,3 Institutional research plan: CEZ:AV0Z30120515 Keywords : repeated borehole temperature logging * karstic environment * Yucatan * groundwater convection * heat transport numerical simulation * fluid dynamics Subject RIV: DC - Siesmology, Volcanology, Earth Structure Impact factor: 2.433, year: 2009

  9. New bromotyrosine alkaloids from the marine sponge Psammaplysilla purpurea

    Digital Repository Service at National Institute of Oceanography (India)

    Tilvi, S.; Rodrigues, C.; Naik, C.G.; Parameswaran, P.S.; Wahidullah, S.

    Institute of Oceanography, August C, D, data. aur and Salmonella activities. Chemical modification occurs both in the side dry weight) was extracted with Methanol (1 L!3) and new compounds was determined based on extensive 1D and established as –NMe at N-9.... In our earlier communication we reported the isolation of known compounds 16-Debromoa- plysamine-4 9,16 and Purpuramine I. 13,16 The present paper deals with the isolation, structures and in vitro bioactivity of bromotyrosine metabolites Purpurealidin A...

  10. JOS JOURNAL MAY-AUGUST

    African Journals Online (AJOL)

    FOBUR

    Juu·t.,mml qf On hope die. A.ddressas.· ctnd Tramm• . . los Univf!rsU)' TeachirtR Ho.'t.pilaf, Jos. "WI.- Divij,'J()rt o('!r.aumn. --'J,,.~ery T>e.pwtmenJ. los. U:niver.~ity ...... 161 mi"'~ ~ ~"'~ ~l\\. Nt,tdK1'1\\ Irclood 1. ~7o-84: tht'! HMtile Aa;oo. C;;b!tt.al.ly Sy~cm . .Or J Surg, 19&9;16: Hl-06-. lO. 17) Hull JB. (]()per GJ. Pattern and.

  11. Periodic Inspections of Cleveland Harbor East Breakwater, Ohio, and Burns Harbor North Breakwater, Indiana

    Science.gov (United States)

    2015-05-01

    dolomite 3. quartzite ERDC/CHL TR-15-6 43 4. Indiana Bedford limestone 5. smaller blocks of limestone that could not be verified as Bedford...limestone. Of the 282 damaged armor stones noted, 46 (16%) were granite, 84 (%) were dolomite, 2 (1%) were quartzite , 136 (48%) were Indiana Bedford...into 4 pieces 322 4+75 4.9 (16) Granite Split into 2 pieces 321 4+75 3.05 (10) Dolomite Split into 2 pieces 320 4+75 5.5 (18) Quartzite Split – in

  12. Saaremaa XX sajandil

    Index Scriptorium Estoniae

    2000-01-01

    Järg Jan/8;11;15;20;27 Feb/1;10;12;17;19;29 Mar/4;7;11;14;21;25;29;30 Apr/1;8;12;27 May/3;6;11;19;26;30 Jun/3;6;16;21;22 Jul/25 Aug/4;11;18;26 Sep/9;16;22;29 Oct/6;10;21;27 Nov/7;11;17;22 Dec/12 Sündmustest Saaremaal. Artiklite autorid: Raul Salumäe, Marko Püüa, Endel Püüa, Külli Rikas, Maret Soorsk, Olavi Pesti, Bruno Pao, Sirje Azarov, Tõnu Talvi

  13. Hiiumaa kiviajast tänapäevani / Endel Saar

    Index Scriptorium Estoniae

    Saar, Endel

    2001-01-01

    Järg Feb/10;17 Mar/3;10;17;24;31 Apr/7;21;28 May/5;26 Jun/2;9;16;30 Jul/7;14;21;28 Aug/4;11;18;25 Sep/8 ;15;22;29 Oct/6;13;20;27 Nov/3;10;24 Dec/1;8;15;22;29. Biosfääri Kaitseala Keskuse poolt koostatud atlas "Administratiivsete muutuste ülevaatekaart", kus antakse ülevaade Hiiumaa arenguloost kiviajast tänapäevani

  14. Saaremaa XX sajandil

    Index Scriptorium Estoniae

    2001-01-01

    Algus: 6. jaanuar 2000. Järg Jan/12;16;26;30/Feb/9;13;22/Mar/6;13;16;27Apr/6;20;27/May/15;31/Jun/12;22/Jul/6;13;27Aug/1;3 Sep/11/Oct/9;16/Nov/6;9/Dec/11. Artiklite autorid: Külli Rikas, Helju Pärt, Garel Püüa, Endel Prooses, Raul Salumäe, Sirje Azarov, Endel Püüa, Maret Soorsk, Aare Laine

  15. Análisis de la eficacia de las acciones de juego del voleibol masculino y femenino de alto rendimiento en la fase inicial, intermedia y final de los sets

    OpenAIRE

    Batista Sucupira, Giuliano

    2014-01-01

    Tesis descargada desde TESEO En esta investigación, se ha presentado el análisis de la eficacia de todas las acciones de juego del voleibol, comparando equipos masculinos y femeninos de alto nivel en las fases inicial (0-8 puntos), intermedia (9-16 puntos) y final (17 hasta fin del set) de cada uno de los sets. Igualmente, se ha realizado el estudio de las correlaciones de las acciones de juego y las comparaciones entre los equipos ganadores y perdedores de los sets para ambos géneros. La ...

  16. Stress-life relation of the rolling-contact fatigue spin rig

    Science.gov (United States)

    Butler, Robert H; Carter, Thomas L

    1957-01-01

    The rolling-contact fatigue spin rig was used to test groups of SAE 52100 9.16-inch-diameter balls lubricated with a mineral oil at 600,000-, 675,000-, and 750,000-psi maximum Hertz stress. Cylinders of AISI M-1 vacuum and commercial melts and MV-1 (AISI M-50) were used as race specimens. Stress-life exponents produced agree closely with values accepted in industry. The type of failure obtained in the spin rig was similar to the subsurface fatigue spells found in bearings.

  17. Air Force Manufacturing Technology Electronics Program, FY72-FY85.

    Science.gov (United States)

    1985-04-01

    of 9-16 watt-hours/pound 60 ending on frequency and depth of discharge. The first phase of the gram with Yardney (F33615-80-C-5036) was a critical...DIRECT PATTERN GENERATION OF PUB 27 WESTINGHOUSE MT FOR PRECISION EXTRUDED ALUMINUM WAVEGUIDES 15 YARDNEY ELECTRI MT FOR NICKEL-HYDROGEN BATTERY CELLS... YARDNEY ELECTRIC CORP. PAWCATUCK CT CONTRACT# : F33615-80-C-5036 OPEN APPROPRIATION : 3020 AMOUNT IN $ X 1000 : 1061 MISSION : C.C.C.I. THRUST : SPACE

  18. Medical Surveillance Monthly Report (MSMR). Volume 18, Number 12, December 2011

    Science.gov (United States)

    2011-12-01

    pregnancy-related medical encounters between the fi rst and last 5 years of the period were history of cesarean delivery , gestational diabetes and...threatened labor” (e.g., false labor), “previous cesarean delivery ” and “normal delivery ”. Th e number of complication-related medical encounters per...37,612 3 24.1 654.2 Previous cesarean delivery 51,867 4 4.5 14,089 16 9.0 644.0 Threatened premature labor 50,761 5 4.4 26,211 9 16.8 650 Normal delivery

  19. Acute appendicitis in children: ultrasound and CT findings in negative appendectomy cases

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seong Ho; Choi, Young Hun; Kim, Woo Sun; Cheon, Jung-Eun; Kim, In-One [Seoul National University Hospital, Department of Radiology, Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2014-10-15

    To decrease the negative appendectomy rate in children, knowledge of the misleading imaging findings on US and CT in negative appendicitis cases is important. To evaluate the negative appendectomy rate and describe the imaging findings of US and CT that lead radiologists to misdiagnose acute appendicitis in children. From 2007 to 2013, 374 children operated for suspected appendicitis were proved to either have acute appendicitis (n = 348) or to be negative for appendicitis (n = 26) on pathological reports. Negative appendectomy rates were compared among imaging modalities, age groups and genders. We retrospectively reviewed US and CT findings from negative appendectomy cases. The overall negative appendectomy rate was 7.0% (26/374). There were no statistically significant differences among the subgroups. The most common misleading presentations on US were sonographic tenderness (9/16, 56%) and non-compressibility (9/16, 56%). The most common misleading finding on CT were the presence of an appendicolith or hyperdense feces (5/12, 42%). Periappendiceal fat inflammation was observed in only one case of negative appendicitis on US and on CT. Radiologists can misdiagnose children with equivocal diameters of appendices as having acute appendicitis when sonographic tenderness or non-compressibility is present on US and when an appendicolith or hyperdense feces is noted on CT. The possibility of negative appendicitis should be borne in mind when periappendiceal fat inflammation is absent or minimal in indeterminate cases. (orig.)

  20. Effect of larvae treated with mixed biopesticide Bacillus thuringiensis-abamectin on sex pheromone communication system in cotton bollworm, Helicoverpa armigera.

    Science.gov (United States)

    Shen, Li-Ze; Chen, Peng-Zhou; Xu, Zhi-Hong; Deng, Jian-Yu; Harris, Marvin-K; Wanna, Ruchuon; Wang, Fu-Min; Zhou, Guo-Xin; Yao, Zhang-Liang

    2013-01-01

    Third instar larvae of the cotton bollworm (Helicoverpa armigera) were reared with artificial diet containing a Bacillus thuringiensis-abamectin (BtA) biopesticide mixture that resulted in 20% mortality (LD20). The adult male survivors from larvae treated with BtA exhibited a higher percentage of "orientation" than control males but lower percentages of "approaching" and "landing" in wind tunnel bioassays. Adult female survivors from larvae treated with BtA produced higher sex pheromone titers and displayed a lower calling percentage than control females. The ratio of Z-11-hexadecenal (Z11-16:Ald) and Z-9-hexadecenal (Z9-16:Ald) in BtA-treated females changed and coefficients of variation (CV) of Z11-16:Ald and Z9-16:Ald were expanded compared to control females. The peak circadian calling time of BtA-treated females occurred later than that of control females. In mating choice experiment, both control males and BtA-treated males preferred to mate with control females and a portion of the Bt-A treated males did not mate whereas all control males did. Our Data support that treatment of larvae with BtA had an effect on the sex pheromone communication system in surviving H. armigera moths that may contribute to assortative mating.

  1. Livestock-associated methicillin and multidrug resistant S. aureus in humans is associated with occupational pig contact, not pet contact.

    Science.gov (United States)

    Ye, Xiaohua; Fan, Yanping; Wang, Xiaolin; Liu, Weidong; Yu, Haifeng; Zhou, Junli; Chen, Sidong; Yao, Zhenjiang

    2016-01-12

    This study aimed to explore the association of livestock-associated S. aureus with occupational pig contact and pet contact. In this cross-sectional study, 1,422 participants (including 244 pig workers, 200 pet-owning workers and 978 control workers) responded to a questionnaire and provided a nasal swab for S. aureus analysis. Resulting isolates were tested for antibiotic susceptibility, the immune evasion cluster (IEC) genes, and multilocus sequence type. Compared with controls, the pig workers demonstrated a greater prevalence of multidrug-resistant S. aureus (MDRSA) [prevalence ratio (PR) = 3.38; 95% CI: 2.07-5.53] and methicillin-resistant S. aureus (MRSA) (PR = 7.42; 95% CI: 3.71-14.83), but the prevalence of MDRSA and MRSA was similar in pet-owning workers and controls. There was a positive relation of frequency of pig contact with prevalence of MDRSA and MRSA carriage. Only pig workers carried MDRSA CC9 (16 isolates) and MRSA CC9 (16 isolates), and all of these isolates were tetracycline resistant and absent of IEC genes. These findings suggest that livestock-associated MRSA and MDRSA(CC9, IEC-negative, tetracycline-resistant) in humans is associated with occupational pig contact, not pet contact, and support growing concern about antibiotics use in pig farms and raising questions about the potential for occupational exposure to opportunistic S. aureus.

  2. Lennart Meri armid ja sidemed : lähimineviku vähetuntud lehekülgi / Peeter Rahnel

    Index Scriptorium Estoniae

    Rahnel, Peeter, 1957-

    2002-01-01

    Järg 11.,18., 25. sept., 2. ,9.,16., 23., 30. okt., 6., 13. nov., lk. 9. Ilmunud ka: Hiiumaa 7., 12., 19., 26. sept. lk. 5, 6; 3., 10., 17., 24., 31. okt., 7., 14. november, lk. 6; Kesknädal, 4.,11., 18.,25 sept.;2., 9., 16. okt., lk. 9. Aruandest ENSV Riikliku Julgeoleku Komitee 2. vastuluure osakonna tööst ajavahemikul 1. aprill 1954 - 1. aprill 1955. Lennart Meri isast Georg Merist kui väidetavast NKVD agendist. Georg Meri Moskvas Butõrka vanglas. Eesti Vabariigi riigitegelastest, kelle NKVD Severurallagis surma mõistis. Perekond Meri käekäigust peale II maailmasõda. Lennart Meri õpingud Tartu Ülikoolis, tegevus VEKSA liinis. Lennart Meri väidetavad kahtlused Ülemnõukogu esimehe Arnold Rüütli suhtes 1990. a. Boriss Jeltsini visiit Eestisse 1990. a. Lennart Meri visiit Moskvasse 1994. a. Lepingule allakirjutamine

  3. Understanding NaI(Tl) crystal background for dark matter searches

    Energy Technology Data Exchange (ETDEWEB)

    Adhikari, G.; Adhikari, P.; Kong, S.Y.; Oh, S.Y. [Sejong University, Department of Physics and Astronomy, Seoul (Korea, Republic of); Ha, C.; Jeon, E.J.; Kim, N.Y.; Lee, H.S.; Park, J.S.; Park, K.S. [Institute for Basic Science (IBS), Center for Underground Physics, Daejeon (Korea, Republic of); Kim, Y.D. [Institute for Basic Science (IBS), Center for Underground Physics, Daejeon (Korea, Republic of); Sejong University, Department of Physics and Astronomy, Seoul (Korea, Republic of)

    2017-07-15

    We have developed ultra-low-background NaI(Tl) crystals to reproduce the DAMA results with the ultimate goal of achieving purity levels that are comparable to or better than those of the DAMA/LIBRA crystals. Even though the achieved background level does not approach that of DAMA/LIBRA, it is crucial to have a quantitative understanding of the backgrounds. We have studied background simulations toward a deeper understanding of the backgrounds and developed background models for a 9.16-kg NaI(Tl) crystal used in the test arrangement. In this paper we describe the contributions of background sources quantitatively by performing Geant4 Monte Carlo simulations that are fitted to the measured data to quantify the unknown fractions of the background compositions. In the fitted results, the overall simulated background spectrum well describes the measured data with a 9.16-kg NaI(Tl) crystal and shows that the background sources are dominated by surface {sup 210}Pb and internal {sup 40}K in the 2-6-keV energy interval, which produce 2.4 counts/day/keV/kg (dru) and 0.5 dru, respectively. (orig.)

  4. Distal tibial fracture treated by minimally invasive plate osteosynthesis after external fixation Retrospective clinical and radiographic assessment

    Directory of Open Access Journals (Sweden)

    Al. Șerban

    2014-02-01

    Full Text Available Fractures of the horizontal surface of the distal tibia are known commonly as pylon or plafond fractures, and represent 1-5% of lower extremity fractures, 7-10% of all tibial fractures. The protocol consisted of immediate (within eight to 24 hours open reduction and internal fixation of the fibula, using a fibular plate or one third tubular plate and application of an external fixator spanning the ankle joint. In the second stage, the treatment of proximal and distal tibial fractures with close reduction and MIPPO technique can preserve soft tissue, simplify operative procedure and decrease wound, obtain rigid internal fixation and guarantee early function exercises of ankle joint. In this study we evaluated 22 patients treated in Clinical Emergency Hospital Constanta between April 2012 - July 2013 diagnosed with multifragmentary fractures of the distal tibia. This study evaluates the treatment of complex fractures of distal tibia with locked plate after external fixation. There were 17 males and 5 females of mean age 51,7 years (31-68. The mean follow-up period was 14 weeks. (Ranging from 9-16 weeks. All patients were fully weight bearing at 16 weeks (ranging 9-16 weeks showing radiological union. There were no cases of failures of fixation, or rotational misalignment. No significant complication was observed in our patients. MIPO is an effective method of treatment for distal tibial fractures, reduce surgical trauma and maintain a more biologically favorable environment for fracture healing, reducing risks of infection and nonunion.

  5. A study of full width at half maximum (FWHM) according to the filter's cut off level in SPECT camera

    International Nuclear Information System (INIS)

    Park, Soung Ock; Kwon, Soo Il

    2003-01-01

    Filtering is necessary to reduce statistical noise and to increase image quality in SPECT images. Noises controlled by low-pass filter designed to suppress high spatial frequency in SPECT image. Most SPECT filter function control the degree of high frequency suppression by choosing a cut off frequency. The location of cut off frequency determines the affect image noise and spatial resolution. If select the low cut off frequency, its provide good noise suppression but insufficient image quantity and high cut off frequencies increase the image resolution but insufficient noise suppression. The purpose of this study was to determines the optimum cut off level with comparison of FWHM according to cut off level in each filters-Band-limited, Sheep-logan, Sheep-logan Hanning, Generalized Hamming, Low pass cosine, Parazen and Butterworth filter in SPECT camera. We recorded image along the X, Y, Z-axis with 99m TcO 4 point source and measured FWHM by use profile curve. We find averaged length is 9.16 mm ∼ 18.14 mm of FWHM in X, Y, and Z-axis, and Band-limited and Generalized Hamming filters measures 9.16 mm at 0.7 cycle/pixel cut off frequency

  6. Preservation of Fertile Mantle Components at Mid-Ocean Ridge

    Science.gov (United States)

    Montesi, L. G.; Behn, M. D.; Standish, J. J.; Dick, H. J.

    2007-12-01

    Recycled lithosphere is suspected to contribute to the geochemical enrichment not only of Ocean Island Basalts (OIB) but also exceptional Mid-Ocean Ridge Basalts collected at ultraslow ridges. In particular, the chemistry of basalts at volcanic centers along the Southwest Indian Ridge oblique supersegment of 9-16°E is best explained by an exceptionally strong contribution from an enriched mafic component mixed in the upwelling mantle. Why this component is so strong at these volcanic centers can be understood in at least two ways. 1) The mantle underneath each volcanic center is anomalous. Such an explanation is equivalent to appealing to small plume-like features underneath each volcanic center. 2) The fertile component is present everywhere but melt migration gathers the resulting magma toward the volcanic centers. In this contribution, we test the second hypothesis using a numerical melt migration model in which magma rises vertically until it encounter the base of the thermal lithosphere. In the SWIR 9-16°E area, variations in ridge axis azimuth produce a strong relief to the base of the lithosphere, which focuses magma towards the location of the observed volcanic centers. Magma produced off-axis, which is dominated by the fertile component, is focused even more strongly than near-axis magma, explaining the relative enrichment of the surface lava. We compare the expected enrichment pattern with the geochemistry of collected lava and show that, were the ridge straighter or spreading faster, this signal would be more difficult to observe.

  7. Mother-to-Child Transmission of Chagas Disease in El Salvador.

    Science.gov (United States)

    Sasagawa, Emi; Aiga, Hirotsugu; Corado Soriano, Edith Yanira; Cuyuch Marroquín, Blanca Leticia; Hernández Ramírez, Marta Alicia; Guevara de Aguilar, Ana Vilma; Romero Chévez, José Eduardo; Ramos Hernández, Hector Manuel; Cedillos, Rafael Antonio; Misago, Chizuru; Kita, Kiyoshi

    2015-08-01

    To estimate the incidence (any mother to child) and rate (from seropositive mother to child) of mother-to-child transmission of Trypanosoma cruzi, a serological census was conducted, targeting pregnant women and infants born to seropositive mothers, in four municipalities of El Salvador. Of 943 pregnant women, 36 (3.8%) were seropositive for T. cruzi. Of 36, 32 proceeded to serological tests of their infants when they became 6-8 months of age. Six infants seropositive at the age of 6-8 months further proceeded to second-stage serological test at the age of 9-16 months. As the result, one infant was congenitally infected. Thus, serological tests at the age of 6-8 months produced five false positives. To ensure earlier effective medication only for true positives, identification of seropositive infants at the age of 9-16 months is crucial. Incidence and rate of mother-to-child transmission were 0.14 (per 100 person-years) and 4.0%, respectively. Estimated number of children infected through mother-to-child transmission in El Salvador (170 per year) was much higher than that of human immunodeficiency virus (HIV; seven per year). It is recommended that serological testing for T. cruzi be integrated into those for HIV and syphilis as part of antenatal care package. © The American Society of Tropical Medicine and Hygiene.

  8. Association between myasthaenia gravis and systemic lupus erythematosus: three case reports and review of the literature.

    Science.gov (United States)

    Castrejón, I; Shum, K; Tseng, C-E; Askanase, A

    2011-11-01

    The coexistence of systemic lupus erythematosus (SLE) and myasthaenia gravis (MG) has been reported previously. Because of their shared clinical characteristics and autoantibody-mediated pathogenesis, an SLE expert panel decided to include MG as one of the 19 neuropsychiatric SLE syndromes. This study reports a cluster of three cases of SLE/MG overlap from our cohort and a review of the published data concerning this overlap of SLE and MG. A systematic Medline review revealed 13 cases described in eight publications from 1994 to 2009. In summary, 12 of the 16 patients (three from our cohort and 13 from the reported cases) were women with an average age of 34 years. The most common SLE manifestations were polyarthritis (15 out of 16 patients), skin rashes (5/16), serositis (5/16), and cytopaenias (10/16). All of the patients were anti-nuclear antibodies (ANA) positive and 15/16 were anti-dsDNA positive. Proximal muscle weakness was the most frequent MG-related symptom (9/16), while 11/16 patients were anti-acetylcholine receptor (anti-AChR) antibody positive and 9/16 had diagnostic electromyography (EMG). These data suggest that MG should to be included in the differential diagnosis of lupus patients with fatigue and muscular weakness together with inflammatory and drug-induced myopathy.

  9. The ratio of the subjective audiometry in patients with acoustic trauma and “noisy” production workers

    Directory of Open Access Journals (Sweden)

    Shydlovska T.А.

    2014-11-01

    Full Text Available Introduction: The problem of diagnosis and treatment of sensorineural hearing loss (SHL, including forms developed under the influence of noise, takes one of the leading places in ot¬olaryngology. However, there are not many studies on acoustic trauma, although this problem has recently become more and more important. Objective: A comparison of subjective audiometry in patients with sensorineural hearing loss after acute acoustic trauma and chronic noise exposure. Materials and methods. In the work the results of exa¬mination of 84 patients with acoustic trauma, 15 healthy as the control group and 15 workers employed on 'noise' occupations as a comparison group are given. Subjective audiometry was fully carried out by clinical audiometer AC-40 «Interacoustics» (Denmark. Hearing indices were investigated in the conventional (0,125-8 kHz and extended (9-16 kHz frequency bands. Results: Subjective audiometry showed a reduction in sound perception in all patients. Ac¬cor¬ding to the threshold tone audiometry in patients with acoustic trauma hearing thresholds were authentically (P <0,05 increased by 4, 6 and 8 kHz tones of conventional (0,125-8 kHz frequency band and by 14-16 kHz tones of the extended (9-16 kHz in comparison with the control group, as with workers employed on noise occupations. All the examined patients had deterioration of speech-test audiometry and above-threshold audiometry. Conclusions: According to su¬b¬jective audiometry, the type similar disorders of auditory function are in patients with acoustic trauma as in patients with long-term noise exposure, but they are more pronounced and develop much faster. The most informative features which show the origin and progression of hearing loss in patients with acoustic trauma are: increasing hearing thresholds by 14 and 16 kHz tones of the extended (9-16 kHz frequency band and by 4, 6 and 8 kHz tones of con¬ven¬tional (0,125-8 kHz frequency band plus the reduction of

  10. Information and Communication Technologies in the Care of the Elderly: Systematic Review of Applications Aimed at Patients With Dementia and Caregivers

    Science.gov (United States)

    2016-01-01

    Background The interest in applying information and communications technology (ICT) in older adult health care is frequently promoted by the increasing and unsustainable costs of health care services. In turn, the unprecedented growth of the elderly population around the globe has urged institutions, companies, industries, and governments to respond to older adults’ medical needs. Objective The aim of this review is to systematically identify the opportunities that ICT offers to health services, specifically for patients with dementia and their families. Methods A systematic review of the literature about ICT applications that have been developed to assist patients with Alzheimer’s disease (AD) and their primary caregivers was conducted. The bibliographic search included works published between January 2005 and July 2015 in the databases Springer Link, Scopus, and Google Scholar. Of the published papers, 902 were obtained in the initial search, of which 214 were potentially relevant. Included studies fulfilled the following inclusion criteria: (1) studies carried out between the years of 2005 and 2015, (2) studies were published in English or Spanish, (3) studies with titles containing the keywords, (4) studies with abstracts containing information on ICT applications and AD, and (5) studies published in indexed journals, proceedings, and book chapters. Results A total of 26 studies satisfied the inclusion criteria for the current review. Among them, 16 were aimed at the patient with AD and 10 at the primary caregivers and/or family members. The studies targeted applications that included assistive technology (44%, 7/16), telecare (37%, 6/16), and telemedicine (31%, 5/16). The information systems (56%, 9/16) and Internet (44%, 7/16) were the most commonly used enabling technologies for the studies. Finally, areas of attention more covered by the studies were care (56%, 9/16), treatment (56%, 9/16), and management (50%, 8/16). Furthermore, it was found that 20

  11. Phase II Interim Report -- Assessment of Hydrocarbon Seepage Detection Methods on the Fort Peck Reservation, Northeast Montana

    Energy Technology Data Exchange (ETDEWEB)

    Monson, Lawrence M.

    2002-04-24

    The following work was performed: (1) collected reconnaissance micro-magnetic data and background field data for Area 1, (2) identified and collected soil sample data in three anomalous regions of Area 1, (3) sampled soils in Northwest Poplar Oil Field, (4) graphed, mapped, and interpreted all data areas listed above, (5) registered for the AAPG Penrose Conference on Hydrocarbon Seepage Mechanisms and Migration (postponed from 9/16/01 until 4/7/02 in Vancouver, B.C.). Results include the identification and confirmation of an oil and gas prospect in the northwest part of Area 1 and the verification of a potential shallow gas prospect in the West Poplar Area. Correlation of hydrocarbon micro-seepage to TM tonal anomalies needs further data analysis.

  12. Features of the SPINK5 gene polymorphism associations with food allergy onset and course in children

    Directory of Open Access Journals (Sweden)

    O. P. Pakholchuk

    2015-08-01

    Full Text Available Resume. It is less known about role of the genetically predisposing factors in the onset and course of the food allergy (FA. We aimed to determine the association of the polymorphism in SPINK5 gene with FA. Materials and methods. DNA genotypes were identified in children aged 2 months – 5 years with FA skin symptoms (n=53 depending on the presence of the guanine or adenine in both alleles in the 1258 position of the 14th exzone. Results. Genomic frequencies of the SPINK5 polymorphism site were 15 (28.3% for AA, 29 (54.7% – AG, 9 (16.9% – GG. Abnormal barrier gene STAT5 did not influence on the severity and kind of the FA symptoms, comorbidity. Children with AA

  13. Twenty weeks of home-based interactive training of children with cerebral palsy improves functional abilities

    DEFF Research Database (Denmark)

    Lorentzen, Jakob; Greve, Line Z; Kliim-Due, Mette

    2015-01-01

    (CP). METHODS: Thirty four children with CP (aged 9-16; mean age 10.9 ± 2.4 years) (GMFCS I-II; MACS I-II) were included in this non-randomized controlled clinical training study. 12 children (aged 7-16; mean age: 11.3+/-0.9 years) were allocated to a control group in which measurements were performed......BACKGROUND: Home-based training is becoming ever more important with increasing demands on the public health systems. We investigated whether individualized and supervised interactive home-based training delivered through the internet improves functional abilities in children with cerebral palsy...... with 20 weeks interval without any intervening training. Daily activities, functional abilities of upper- and lower limbs, and balance were evaluated before, immediately after training and 12 weeks after training. The training consisted of 30 min daily home-based training for 20 weeks delivered through...

  14. [Physical self-concept, anxiety, depression, and self-esteem in children with cancer and healthy children without cancer history].

    Science.gov (United States)

    Bragado, Carmen; Hernández-Lloreda, Ma José; Sánchez-Bernardos, Ma Luisa; Urbano, Susana

    2008-08-01

    The main purpose of this study is to test if children with cancer receiving chemotherapy show a poorer physical self-concept, less self-esteem and more anxiety and depression than healthy children (with no cancer history) within the same age range (9-16 years old) and social condition. Furthermore, the capacity of self-concept and self-esteem to predict emotional distress is analyzed. The Spanish versions of PSDQ, CDI and STAIC were administered to 30 children with cancer and 90 healthy children. Except for the health and flexibility dimensions in the PSDQ, no significant differences between groups were found. Self-esteem was the best predictor of depression, whereas health and self-concept predicted anxiety.

  15. High-functioning autism and Asperger's disorder: utility and meaning for families.

    Science.gov (United States)

    Ruiz Calzada, Luisa; Pistrang, Nancy; Mandy, William P L

    2012-02-01

    We used framework analysis to investigate the utility of pervasive developmental disorder diagnoses, interviewing young people (aged 9-16 years) with high-functioning autistic disorder (AD) and Asperger's disorder (AsD), and their parents. Twenty two participants from ten families described both gains and costs resulting from diagnosis. Perceived advantages of AD and AsD diagnosis were increased understanding and practical support, and parental empowerment. Disadvantages included the effects of stigma and concerns about validity. Participants tended to consider AsD and AD as interchangeable terms. Findings suggest that the utility of AD and AsD depends upon both their validity and how these diagnoses are received in their cultural, economic and legislative context. Improvement of post-diagnostic services will improve the utility of AD and AsD.

  16. Optical fiber design with orbital angular momentum light purity higher than 99.9.

    Science.gov (United States)

    Zhang, Zhishen; Gan, Jiulin; Heng, Xiaobo; Wu, Yuqing; Li, Qingyu; Qian, Qi; Chen, Dongdan; Yang, Zhongmin

    2015-11-16

    The purity of the synthesized orbital-angular-momentum (OAM) light in the fiber is inversely proportional to channel crosstalk level in the OAM optical fiber communication system. Here the relationship between the fiber structure and the purity is firstly demonstrated in theory. The graded-index optical fiber is proposed and designed for the OAM light propagation with the purity higher than 99.9%. 16 fiber modes (10 OAM modes) have been supported by a specific designed graded-index optical fiber with dispersion less than 35 ps/(km∙nm). Such fiber design has suppressed the intrinsic crosstalk to be lower than -30 dB, and can be potentially used for the long distance OAM optical communication system.

  17. Effect of diets containing whole cottonseed on the quality of sheep semen - doi: 10.4025/actascianimsci.v34i3.12963

    Directory of Open Access Journals (Sweden)

    Adriana Trindade Soares

    2012-05-01

    Full Text Available This study evaluated the semen quality of Santa Ines sheep fed diets containing different levels of whole cottonseed (WCS. Twenty sheep were distributed into four groups that were given diets with 0; 20; 30; 40% of WCS. For this study the semen was collected by electroejaculation, and a monthly andrological examination was performed during nine months. The analyzed variables were: scrotal circumference (SC, appearance and color of the ejaculate, progressive motility (PM, vigor, mass movement (MM, total sperm concentration (spzX109, sperm morphology (SM and blood hematocrit. The SC had no difference among diets, with mean 31.83 cm. The animals fed diets with WCS, presented mean intake of 9.16 mg gossypol kg BW, and were prone to present greenish semen, and appearance ranging from thin creamy to watery. The PM decreased linearly (p

  18. Periodic breathing and oxygen supplementation in Chilean miners at high altitude (4200m).

    Science.gov (United States)

    Moraga, Fernando A; Jiménez, Daniel; Richalet, Jean Paul; Vargas, Manuel; Osorio, Jorge

    2014-11-01

    Our objective was to determine the nocturnal ventilatory pattern and characterize the effect of oxygen enrichment on nocturnal ventilatory pattern and sleep quality in miners exposed to intermittent hypobaric hypoxia at 4200m. A total of 16 acclimatized miners were studied. Nocturnal ventilatory pattern (plethysmographic inductance), arterial oxygen saturation and heart rate (pulse oximetry) were performed in 9/16 subjects. Sleep quality at high altitude was assessed by self-questionnaires in 16/16 subjects. All measurements were performed during at least 7h of sleep. Subjects were studied while sleeping at high altitude without (control, C) and with oxygen supplementation (FiO2=0.25, treated, T). Periodic breathing (%) C: 25±18 vs T: 6.6±5.6 (pbreathing with apneas was present in miners exposed to high altitude for 1 to 4 years and was reduced by treatment with supplementary oxygen. Copyright © 2014 Elsevier B.V. All rights reserved.

  19. Rapid sea level rise in the aftermath of a Neoproterozoic snowball Earth.

    Science.gov (United States)

    Myrow, P M; Lamb, M P; Ewing, R C

    2018-04-19

    Earth's most severe climate changes occurred during global-scale snowball-Earth glaciations, which profoundly altered Earth's atmosphere, oceans, and biosphere. Extreme rates of glacio-eustatic sea-level rise are a fundamental prediction of the snowball Earth hypothesis, but supporting geologic evidence is lacking. We use paleohydraulic analysis of wave ripples and tidal laminae of the Elatina Formation, Australia - deposited following the Marinoan glaciation ca. 635Ma - to show that water depths of 9-16m remained nearly constant for ~100yrs throughout 27m of sediment accumulation. This accumulation rate was too great to have been accommodated by subsidence, and instead indicates an extraordinarily rapid rate of sea-level rise (0.2-0.27m/yr). Our results substantiate a fundamental prediction of snowball Earth models of rapid deglaciation during the early transition to a super-greenhouse climate. Copyright © 2018, American Association for the Advancement of Science.

  20. President Ilves sõitis USAsse poega õnnitlema / Jaan Väljaots

    Index Scriptorium Estoniae

    Väljaots, Jaan, 1968-

    2009-01-01

    President Toomas Hendrik Ilves on koos proua Evelin Ilvese ja kümneliikmelise IT-ettevõtjate äridelegatsiooniga 9.-16.06.2009 töövisiidil USA läänerannikul California osariigis, et tutvustada Eestit ja Eesti tehnoloogiaettevõtjaid ning edendada teadus- ja kõrgtehnoloogia arenduse piirkonnas Silicon Valleys koostööd kohalike ettevõtjatega. Visiidi sisse mahub presidendi poja Luukas Kristjan Ilvese lõpuaktus Stanfordi ülikoolis. Selgitab presidendi pressinõunik Toomas Sildam. Vt. samas: Evelin Ilves: rasvumisega tuleb võidelda kõikjal. Presidendi abikaasa tutvus San Franciscos sotsiaalprojektiga "Glide" ning kohtus Standfordi meditsiinikoolis toitumisspetsialistide ja pediaatritega. Vt. ka juhtkiri lk. 6: Kaks ühe hinnaga

  1. Clinical application of percutaneous needling lung abscess drairnage under CT guidance

    International Nuclear Information System (INIS)

    Hu Xiaokun; Wang Mingyou; Li Chenjun; Lv Dongfang; Li Xiaodong; Yu Zhaocun

    2004-01-01

    Objective: To discuss the clinical application of drainage for lung abscess by needle puncture under CT guidance. Methods: 18 cases of lung abscess were drainaged by needle puncture under CT guidance, including direct aspiration by puncture needle 1-3 times (n=8) and retaining drainage tube continuously (n=10). Results: 17 cases with this procedure were succeeded possessing success rate of 94.7%(17/18). The patients were followed up for 11-35 days with symptom relieving better obviously and the focus shrinkage or disappeared (n=16), the curative rate reached 88.9%(16/18). The main complication was pneumothorax with capacities of 30%(n=1). Conclusions: The curative course of lung abscess can be shortened greatly by percutaneous needling drainage under CT guidance with mild trauma. The procedure is simple with high successful rate and less complication. (authors)

  2. Chemical constituents of the essential oil and organic acids from longkong (Aglaia dookkoo Griff. fruits

    Directory of Open Access Journals (Sweden)

    Abdulhakim Hamad

    2006-03-01

    Full Text Available The pulp of longkong fruits (Aglaia dookkoo Griff., collected from Narathiwat province, was dried and extracted by steam distillation to obtain the essential oil in 0.48% yield. The GC-MS data showed oleic acid (14.80%, α-copaene (11.15%, germacrene-D (9.16%, δ- cadinene (6.74%, τ -muurolol (6.34%, (+ spathulenol (5.72% and palmitic acid (5.49% as the major constituents. Organic acids were also extracted from dried pulp with methanol using a Soxhlet apparatus to give the crude extract in 36.26% yield. Four organic acids: glycolic, maleic, malic and citric acids were determined by HPLC. Maleic acid (1.23% was the major acid and the others were citric (0.22%, malic (0.15% and glycolic acids (0.14%.

  3. Factors affecting the abundance of wild rabbit (Oryctolagus cuniculus in agro-ecosystems of the Mount Etna Park

    Directory of Open Access Journals (Sweden)

    Susanna Caruso

    2001-09-01

    Full Text Available Abstract A study on the abundance of Wild rabbit Oryctolagus cuniculus and environmental factors which may affect its occurrence in agro-ecosystems of Mount Etna was carried out in 1998. Density data, collected monthly by pellet counts in 7 sample areas, show a mean value of 9.16 individuals per hectare; in two samples high density values were recorded and the difference compared to other areas was significant. Two peaks of abundance were recorded during the year. No significant correlation was found between rabbit density and the factors considered but altitude and percentage of abandoned cultivation seem to have a certain influence on the occurrence of the species. The main natural predators, Vulpes vulpes and Buteo buteo, do not have any negative effect on rabbit abundance.

  4. Biodiversity, threats and conservation challenges in the Cerrado of Amapá, an Amazonian savanna

    Directory of Open Access Journals (Sweden)

    Karen Mustin

    2017-10-01

    Full Text Available An Amazonian savanna in northern Brazil known as the Cerrado of Amapá is under imminent threat from poor land-use planning, the expansion of large-scale agriculture and other anthropogenic pressures. These savannas house a rich and unique flora and fauna, including endemic plants and animals. However, the area remains under-sampled for most taxa, and better sampling may uncover new species. We estimate that only ~9.16% of these habitats have any kind of protection, and legislative changes threaten to further weaken or remove this protection. Here we present the status of knowledge concerning the biodiversity of the Cerrado of Amapá, its conservation status, and the main threats to the conservation of this Amazonian savanna. To secure the future of these unique and imperilled habitats, we suggest urgent expansion of protected areas, as well as measures that would promote less-damaging land uses to support the local population.

  5. Properties of aerogels in glazings

    DEFF Research Database (Denmark)

    Schultz, Jørgen Munthe

    1998-01-01

    This report describes the final tests carried out on an advanced apparatus for measurement of thermal conductivity of materials at atmospheric pressure and different levels of evacuation. The apparatus was designed and constructed in the phase 1 of the project. Difficulties with the control system...... have been solved and measurements have been carried out on common polystyrene foam insulation at atmospheric pressure. The measurements have been compared with results from reference measurements and a difference of only 0.3% was found in measured thermal conductivity. Measurements on monolithic silica...... aerogel were performed at 5 different pressure levels in the range 0.2 - 1000 hPa. The measured equivalent thermal conductivity is in the range 8.9 - 16.4 mW/(m K) which corresponds very well with results obtained by institutes in Germany and France....

  6. Fabry disease in children

    DEFF Research Database (Denmark)

    Borgwardt, Line Gutte; Feldt-Rasmussen, U; Rasmussen, AK

    2013-01-01

    Fabry disease is a rare, multiorgan disease. The most serious complications involve the kidney, brain and heart. This study aims to assess the effect of enzyme replacement therapy (ERT) using agalsidase-beta in children with Fabry disease. We carried out a nationwide, descriptive and observational...... retrospective cohort study of 10 children (9-16 years at baseline), who underwent regular systematic investigations for 1-8 years after initiation of ERT with agalsidase-beta (Fabryzyme®, Genzyme). Ophthalmological, echocardiographic abnormalities and hypohidrosis were found at baseline and during the follow......-up period. Serious kidney, heart or brain involvement had not developed at the last follow-up examination. For the majority of the patients improvements were found concerning headache, acroparaesthesias and gastrointestinal pain during the follow-up period. The level of energy and physical activity also...

  7. CT staging of renal cell carcinoma: Emphasis on perinephric tumor extension

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Yun Young; Kim, Sun Mi; Choi, Mun Hwan; Bang, Duk Ja; Koh, Byung Hee; Cho, On Koo [Hanyang University College of Medicine, Seoul (Korea, Republic of)

    1993-07-15

    A total of 47 preoperative CT scans in patients with renal cell carcinoma were retrospectively reviewed and compared with surgical findings to assess the accuracy of CT for determining the perinephric tumor extension. CT criteria for perinephric extension were hazy ill-defined tumor margin, perirenal nodule and fascial thickening. Regardless of the tumor stage, the accuracy of CT in detecting perinephric extension was 76.6% (36/47), with a sensitivity of 88.9% (16/18) and specificity of 68.9% (20/29). The cause of understaging (n=2) was microscopic infiltration of the perinephric space. The causes of overstaging were tumor infiltration to the renal capsule (n=5), partial adhesion with the perinephric fat (n=3) and renal vein thrombosis (n=1). A smooth clear tumor margin is highly reliable sign for stage I but infiltrative findings onto renal capsule and perirenal fat could be considered stage I.

  8. Conceptual thermal design and analysis of a far-infrared/mid-infrared remote sensing instrument

    Science.gov (United States)

    Roettker, William A.

    1992-07-01

    This paper presents the conceptual thermal design and analysis results for the Spectroscopy of the Atmosphere using Far-Infrared Emission (SAFIRE) instrument. SAFIRE has been proposed for Mission to Planet Earth to study ozone chemistry in the middle atmosphere using remote sensing of the atmosphere in the far-infrared (21-87 microns) and mid-infrared (9-16 microns) spectra. SAFIRE requires that far-IR detectors be cooled to 3-4 K and mid-IR detectors to 80 K for the expected mission lifetime of five years. A superfluid helium dewar and Stirling-cycle cryocoolers provide the cryogenic temperatures required by the infrared detectors. The proposed instrument thermal design uses passive thermal control techniques to reject 465 watts of waste heat from the instrument.

  9. Digitally empowered? Portuguese children and the national poli- cies for internet inclusion

    Directory of Open Access Journals (Sweden)

    Cristina Ponte

    2012-05-01

    Full Text Available Accessing the internet more than their parents, two out of three Portuguese children and youths (9-16 years have laptops and go online in their bedrooms while one in four use public libraries to access the internet, both values being above the European average. Summing up the national ICT policies that led to the wide availability of laptops together with the development of a public network of centers, this paper is based on two research presents profiles of Portuguese children and youth attending those centers. The analysis demonstrates their enthusiasm as internet users as well as the constraints and challenges in being empowered with informational and communicational skills.

  10. Fresh meat color evaluation using a structured light imaging system

    DEFF Research Database (Denmark)

    Trinderup, Camilla Himmelstrup; Kim, Yuan H. Brad

    2015-01-01

    The objective of this study was to investigate the efficacy of a computer vision system (CVS) with structured light for meat color assessment. Three muscles (longissimus dorsi (LD), semimembranosus (SM), and psoas major (PM)) from eight beef carcasses were obtained at 1 day postmortem, vacuum...... packaged and assigned to three aging periods (9, 16, and 23 days). After aging, steaks were cut and displayed for 7 days at 3 °C under light. The surface colors were evaluated by using a Minolta, the CVS and trained color panel. In general, the CVS was highly correlated to the sensory scores, and showed...... an equivalent meat color assessment compared to the colorimeter. The CVS had a significantly higher correlation with the panel scores for the lighter and more color stable samples compared to the colorimeter. These results indicate that the CVS with structured light could be an appropriate alternative...

  11. Effect of communication style and physician-family relationships on satisfaction with pediatric chronic disease care.

    Science.gov (United States)

    Swedlund, Matthew P; Schumacher, Jayna B; Young, Henry N; Cox, Elizabeth D

    2012-01-01

    Over 8% of children have a chronic disease and many are unable to adhere to treatment. Satisfaction with chronic disease care can impact adherence. We examine how visit satisfaction is associated with physician communication style and ongoing physician-family relationships. We collected surveys and visit videos for 75 children ages 9-16 years visiting for asthma, diabetes, or sickle cell disease management. Raters assessed physician communication style (friendliness, interest, responsiveness, and dominance) from visit videos. Quality of the ongoing relationship was measured with four survey items (parent-physician relationship, child-physician relationship, comfort asking questions, and trust in the physician), while a single item assessed satisfaction. Correlations and chi square were used to assess association of satisfaction with communication style or quality of the ongoing relationship. Satisfaction was positively associated with physician to parent (p relationships (p communication style and the quality of the ongoing relationship contribute to pediatric chronic disease visit satisfaction.

  12. Accession Medical Standards Analysis and Research Activity (AMSARA) Annual Report 2009

    Science.gov (United States)

    2009-09-29

    14 1.6 735.0 Hallux valgus 5 0.8 8 0.8 12 1.3 746 Congenital anomalies of heart and great vessels 11 1.7 4 0.4 9 1.0 719.41 Shoulder pain...Elevated blood pressure reading without a diagnosis of hypertension 240 1.4 190 1.9 P11.7 Refractive surgery 236 1.4 198 1.9 367 Disorders of...0.4 34 0.4 52 0.9 16 0.5 Refractive surgery including Lamellar 234 1.8 213 2.4 51 0.8 39 1.1 Individuals with one or more conditions that are not

  13. Cosmic expansion and growth histories in Galileon scalar-tensor models of dark energy

    International Nuclear Information System (INIS)

    Kobayashi, Tsutomu

    2010-01-01

    We study models of late-time cosmic acceleration in terms of scalar-tensor theories generalized to include a certain class of nonlinear derivative interaction of the scalar field. The nonlinear effect suppresses the scalar-mediated force at short distances to pass solar-system tests of gravity. It is found that the expansion history until today is almost indistinguishable from that of the ΛCDM model or some (phantom) dark energy models, but the fate of the universe depends clearly on the model parameter. The growth index of matter density perturbations is computed to show that its past asymptotic value is given by 9/16, while the value today is as small as 0.4.

  14. Clinical features, diagnosis, treatment and molecular studies in paediatric Cushing's syndrome due to primary nodular adrenocortical hyperplasia

    DEFF Research Database (Denmark)

    Storr, Helen L; Mitchell, J H; Swords, F M

    2004-01-01

    BACKGROUND: Primary nodular adrenocortical hyperplasia (PNAH) is a well recognized, but infrequently studied cause of paediatric Cushing's syndrome (CS). OBJECTIVE: To assess presentation, diagnosis, radiological imaging, treatment and molecular analysis of patients with childhood-onset CS due...... to PNAH. PATIENTS: Four males and two females (median age 12.9 years, range 10.9-16.9 years) were studied. RESULTS: All had growth failure (mean height SDS -1.2; range -2.5-0.0), weight gain [mean body mass index (BMI) SDS 3.5; range 2.5-4.6] and clinical virilization, while five had hypertension [mean...... systolic blood pressure (SBP) 130 mmHg, diastolic blood pressure (DBP) 83 mmHg]. One patient had generalized lentigines, one had a tibial chondromyxomatous cyst and two had facial freckling. One patient had a family history of primary nodular adrenocortical disease. The diagnosis of CS was based...

  15. Adverse life events as risk factors for behavioural and emotional problems in a 7-year follow-up of a population-based child cohort

    DEFF Research Database (Denmark)

    Rasmussen, Cathrine Skovmand; Nielsen, Louise Gramstrup; Petersen, Dorthe Janne

    2014-01-01

    Background and aim: The aim of the study was to identify risk factors for significant changes in emotional and behavioural problem load in a community-based cohort of Danish children aged 9-16 years, the risk factors being seven parental and two child-related adverse life events. Methods: Data...... on emotional and behavioural problems was obtained from parents filling in the Child Behavior Checklist (CBCL) when the child was 8-9 and again when 15 years old. Data on risk factors was drawn from Danish registers. Analysis used was logistic regression for crude and adjusted change. Results: Parental divorce......, decreasers, high persisters and low persisters), we found that children with a consistently high level of behavioural problems also had the highest number of adverse life events compared with any other group. Conclusions: Family break-up was found to be a significant risk factor. This supports findings...

  16. Chemical composition and evaluation of the antimicrobial activity of the essential oil from leaves of Eugenia platysema.

    Science.gov (United States)

    Tenfen, Adrielli; Siebert, Diogo Alexandre; Yamanaka, Celina Noriko; Mendes de Córdova, Caio Maurício; Scharf, Dilamara Riva; Simionatto, Edésio Luiz; Alberton, Michele Debiasi

    2016-09-01

    This study describes the qualitative and quantitative chemical composition and evaluates the antibacterial activity of essential oil from Eugenia platysema leaves. Analysis by GC-FID and GC-MS allowed the identification of 22 compounds. Different from the other species of the Eugenia genus, the major compound found in the essential oil was the diterpene phytol (66.05%), being this the first report of the presence of this compound in the essential oils from Eugenia genus. The sesquiterpene elixene was the second most concentrated compound in the studied essential oil (9.16%). The essential oil from E. platysema was tested for its antibacterial activity against cell-walled bacteria and mollicute strains of clinical interest using the microdilution broth assay. The results showed that the essential oil of E. platysema was inactive until 1000 μg mL(-1) against tested bacteria.

  17. Networked Pd (core) @ polyaniline (shell) composite: Highly electro-catalytic ability and unique selectivity

    Science.gov (United States)

    Xia, Youyi; Liu, Ning; Sun, Ling; Xu, Hao; Gao, Hong; Lu, Taofeng

    2018-01-01

    A networked composite (Pd@PANI), which is self-assemblied freely from Pd (core) @polyaniline (shell) nanoparticles, has been prepared successfully by a facilely one-step approach. Owing to the conductive environment and acid-doped behavior provided by PANI, the composite exhibits highly catalytic ability in the reaction involving acidic reactants. For instance, in the HCOOH electro-oxidation, 9.16 times of specific activity (comparing with that when using commercial Pd/C catalyst) is observed. Meanwhile, the as-prepared product is unable to catalyze some other systems like the electro-oxidation of C2H5OH, showing novel and unique selectivity. Those would open up new routes for synthesizing high-performance Pd-based catalysts, and could also shed some light on synthesizing new types of selective catalysts.

  18. Molecular Dynamics Simulations of Water Nanodroplets on Silica Surfaces

    DEFF Research Database (Denmark)

    Zambrano, Harvey A; Walther, Jens Honore; Jaffe, Richard L.

    2009-01-01

    and DNA microarrays technologies.4,5,6,7,8 Although extensive experimental, theoretical and computational work has been devoted to study the nature of the interaction between silica and water,2,9-16 at the molecular level a complete understanding of silica-water systems has not been reached. Contact angle...... computations of water droplets on silica surfaces offers a useful fundamental and quantitative measurement in order to study chemical and physical properties of water-silica systems.3,16,17,18 For hydrophobic systems the static and dynamic properties of the fluid-solid interface are influenced by the presence...... of air. Hence, nanobubles have been observed and proposed as the origin of long range ``hydrophobic'' forces19-30 even for hydrophilic silica-water interfaces unusual phenomena related to nanobubbles have been observed.31-33 In this work we study the role of air on the wetting of amorphous silica...

  19. Macronutrientes em folhas diagnósticas do capim-tanzânia adubado com nitrogênio e cálcio

    OpenAIRE

    Silveira,Cristiane Prezotto; Monteiro,Francisco Antonio

    2010-01-01

    Um experimento foi realizado em casa de vegetação com capim-tanzânia adubado com combinações de nitrogênio e de cálcio em solução nutritiva no período da primavera. O delineamento estatístico foi de blocos ao acaso, com quatro repetições, em esquema fatorial 5² incompleto, com cinco doses de nitrogênio (2; 9; 16; 23 e 30 mmol L-1) e cinco de cálcio (0,50; 1,75; 3,00; 4,25 e 5,50 mmol L-1), resultando em 13 combinações nitrogênio:cálcio (mmol L-1): 2:0,50; 2:3,00; 2:5,50; 9:1,75; 9:4,25; 16:0,...

  20. 2012 Anthropometric Survey of U.S. Army Personnel: Methods and Summary Statistics

    Science.gov (United States)

    2014-12-05

    0.37 16 0.81 United Kingdom 4 0.10 7 0.35 Vietnam 9 0.22 4 0.20 Other Locations Africa 32 0.78 12 0.60 Asia 23 0.56 19 0.96 Caribbean...43 2.17 1763 88.77 19.75 - 19.90 232 5.68 1791 43.88 95 4.78 1858 93.55 19.90 - 20.05 511 12.52 2302 56.39 23 1.16 1881 94.71 20.05 - 20.20...3.88 1767 88.97 126.25 - 127.75 295 7.23 1440 35.28 91 4.58 1858 93.55 127.75 - 129.25 374 9.16 1814 44.44 54 2.72 1912 96.27 129.25 - 130.75

  1. Structure-Activity Relationship Studies on Derivatives of Eudesmanolides from Inula Helenium as Toxicants against Aedes Aegypti Larvae and Adults

    Science.gov (United States)

    2010-01-01

    39.4) 6.27 (0.82) 9.16 10 4k 19.7 (17.9–21.9) 7.44 (1.06) 6.50 9 3k 20.6 (18.0–23.7) 7.59 (1.03) 16.56 10 4l 30.5 (27.3–33.8) 8.47 (1.36) 10.83 10 3l...MS/MS. GC was equipped with a DB-5 column (30 m0.25 mm fused silica cap. column, film thickness of 0.25 mm) operated using the following conditions...similarities into three distinct fractions (A–C). Fr . B provided 45.9 mg of pure (2R,3R,5S,8aR)- 1,2,3,5,6,7,8,8a-octahydro-3-[(2S)-1-hydroxypropan-2-yl

  2. Seleção de Fungicidas para Controle de Oídio em Eucalipto Selection of Fungicides for Control of Eucalypt Powdery Mildew

    Directory of Open Access Journals (Sweden)

    Rafaela Mazur Bizi

    2011-03-01

    Full Text Available

    O objetivo deste estudo foi encontrar fungicidas eficientes contra o oídio do eucalipto. Foram testados os fungicidas chlorothalonil (2 g/l, fenarimol (0,5 ml/l, enxofre (3 g/l, tebuconazole (1 ml/l, propiconazol 12,5% + trifloxistrobina 12,5% (0,6 ml/l, benzothiadiazol (1g/l, piraclostrobina 13,3% + epoxiconazol 5% (1ml/l e triadimenol (1 ml/l. Os fungicidas foram pulverizados em 30 mudas por tratamento de Eucalyptus benthamii, naturalmente infectadas. A doença foi avaliada aos 9, 16, 23, 30 e 37 dias após serem colocadas em um ambiente infectado, onde os sintomas foram classificados em uma escala de notas que variam de 0 (ausência de sintomas a 4 (sintoma muito forte. Os melhores tratamentos foram piraclostrobina + epoxiconazol, propiconazol + trifloxistrobina e triadimenol, apresentando um índice médio de infecção de 0,39 e 0,63 e 1,01, respectivamente.  
    The objective of this study was to find effective fungicides against eucalypt powdery mildew. Fungicides tested were chlorothalonil, fenarimol, sulfur, tebuconazole, propiconazole, benzothiazole, pyraclostrobin + epoxiconazole and triadimenol. These fungicides were sprayed on Eucalyptus benthamii seedlings in a greenhouse infested with powdery mildew. Severity was evaluated at 9, 16, 23, 30 and 37 days after spraying, classifying symptoms observed with a scale 0 (symptoms absent to 4 (strong symptoms. Best treatments were obtained with pyraclostrobin + epoxiconazole, propiconazole + trifloxystrobin and triadimenol, with an infection index average of 0.39, 0.63 and 1.01, respectively.

  3. Effects of crystalline menthol on blood metabolites in Holstein steers and in vitro volatile fatty acid and gas production.

    Science.gov (United States)

    Van Bibber-Krueger, C L; Miller, K A; Aperce, C C; Alvarado-Gilis, C A; Higgins, J J; Drouillard, J S

    2016-03-01

    Fifty-two Holstein steers (573 ± 9.92 kg BW) were used to determine if oral administration of crystalline menthol would induce changes in endogenous secretions of IGF-1 and circulating concentrations of glucose, lactate, and plasma urea nitrogen (PUN). Steers were blocked by BW and assigned within block to treatment. Treatments consisted of 0, 0.003, 0.03, or 0.3% crystalline menthol (DM basis) added to the diet. Animals were housed in individual, partially covered pens equipped with feed bunks and automatic water fountains. On d 1 of the experiment, blood samples were obtained via jugular venipuncture at 0, 6, 12, 18, and 24 h after feeding. Treatment administration commenced on d 2, and blood samples were again drawn at 0, 6, 12, 18, and 24 h after feeding. This blood-sampling schedule was repeated on d 9, 16, 23, and 30. Plasma was analyzed for PUN, glucose, and lactate concentrations. Serum was used to analyze IGF-1 concentration. Body weights were measured on d 1, 9, 16, 23, and 30. To accompany the live animal phase, in vitro fermentations were performed using ruminal fluid cultures. Measurements included VFA concentrations and fermentative gas production for cultures containing crystalline menthol at 0, 0.003, 0.03, or 0.3% of substrate DM. Addition of menthol to the diet of steers resulted in a treatment × day interaction ( lightest BW until d 30. A menthol × day interaction was observed for daily feed deliveries ( 0.21). In conclusion, menthol supplementation minimally affected blood parameters associated with growth or ruminal fermentative activity.

  4. Information and Communication Technologies in the Care of the Elderly: Systematic Review of Applications Aimed at Patients With Dementia and Caregivers.

    Science.gov (United States)

    Martínez-Alcalá, Claudia I; Pliego-Pastrana, Patricia; Rosales-Lagarde, Alejandra; Lopez-Noguerola, J S; Molina-Trinidad, Eva M

    2016-05-02

    The interest in applying information and communications technology (ICT) in older adult health care is frequently promoted by the increasing and unsustainable costs of health care services. In turn, the unprecedented growth of the elderly population around the globe has urged institutions, companies, industries, and governments to respond to older adults' medical needs. The aim of this review is to systematically identify the opportunities that ICT offers to health services, specifically for patients with dementia and their families. A systematic review of the literature about ICT applications that have been developed to assist patients with Alzheimer's disease (AD) and their primary caregivers was conducted. The bibliographic search included works published between January 2005 and July 2015 in the databases Springer Link, Scopus, and Google Scholar. Of the published papers, 902 were obtained in the initial search, of which 214 were potentially relevant. Included studies fulfilled the following inclusion criteria: (1) studies carried out between the years of 2005 and 2015, (2) studies were published in English or Spanish, (3) studies with titles containing the keywords, (4) studies with abstracts containing information on ICT applications and AD, and (5) studies published in indexed journals, proceedings, and book chapters. A total of 26 studies satisfied the inclusion criteria for the current review. Among them, 16 were aimed at the patient with AD and 10 at the primary caregivers and/or family members. The studies targeted applications that included assistive technology (44%, 7/16), telecare (37%, 6/16), and telemedicine (31%, 5/16). The information systems (56%, 9/16) and Internet (44%, 7/16) were the most commonly used enabling technologies for the studies. Finally, areas of attention more covered by the studies were care (56%, 9/16), treatment (56%, 9/16), and management (50%, 8/16). Furthermore, it was found that 20 studies (77%, 8/26) evaluated their ICT

  5. The study of diagnosis status and, transfer time of stroke patients transferred by pre-hospital emergency medical system (EMS to Vali-Asr hospital in Arak City

    Directory of Open Access Journals (Sweden)

    Saiedeh Bahrampouri

    2013-08-01

    Full Text Available Introduction: Stroke is main cause of death and disability in worldwide and emergency care can decrease complications. Emergency Medical System transferred half of stroke patients to hospital, so improve accuracy of diagnosis may accelerated treatment. This study aimed to determine diagnosis status and, transfer time of stroke patients transferred by prehospital Emergency Medical System to hospital in Arak City. Methods: This study was descriptive -analytic study and all 43 patient’s records with a diagnosis of stroke that transferred by Emergency Medical System to hospital in Arak City was selected. The study Checklist was contained information about age, sex, type of accident prehospital, response time, scene time, transfer time and total time from inpatients records and Emergency Center statistics .Regarding data analysis,SPSS19 software and descriptive statistical tests were used. Results: Mean (SD of age all patients were 73/7±3/8 and 51/2% were women. Ambulance paramedics' stroke diagnosis was correct in 15 (34/9%,20(46/5%of false and 8(18/6% not diagnosed for stroke patients who initially presented to them. The most common non stroke conditions were confusion. Mean response time and scene time, transfer time and total time were 6/9,16/9,9/1 and 35/3 minutes, respectively. In patients with correct diagnose stroke, mean response, scene, transfer and total time were 7,17/1,3/9 and 35/7 minutes. The people with the wrong diagnosis or no diagnosis of stroke by emergency medical personnel were taken to hospital, Mean response, scene, transfer and total time were 6/9, 16/8,9/7 and 33/5 minutes. Conclusions: The results of this study showed that, the correct diagnosis by EMS personnel could be resulted faster transferring patient to definite treatment center.It is recommended to develop prehospital diagnosis tool of stroke, which is contextually adapted and appropriate to facilitate diagnose of strokes and improve the quality of care.

  6. Composition, functional properties and sensory characteristics of Mozzarella cheese manufactured from different somatic cell counts in milk

    Directory of Open Access Journals (Sweden)

    Evelise Andreatta

    2009-10-01

    Full Text Available In the present study, composition, functional properties and sensory characteristics of Mozzarella cheese produced from milk with somatic cell counts (SCC at low (800,000 cells/mL levels were investigated. Three batches of cheese were produced for each SCC category. The cheeses were vacuum packed in plastic bags and analysed after 2, 9, 16, 23 and 30 days of storage at 4ºC. SCC level did not affect the moisture, fat, total protein and ash content, mesophilic and psychrotrophic bacteria, and sensory parameters of Mozzarella cheese. However, meltability increased in cheese manufactured from high SCC milk. Results indicated that raw milk used to produce Mozzarella cheese should not contain high SCC (>800,000 cells/mL in order to avoid changes in the functional properties of the Mozzarella cheese.No presente estudo foram investigadas a composição, as propriedades funcionais e as características sensoriais do queijo Mussarela produzido a partir de leite com contagens de células somáticas (CCS em níveis baixos (800.000 CS/mL. Foram produzidos 3 lotes de queijo para cada CCS. Os queijos foram embalados a vácuo e analisados após 2, 9, 16, 23 e 30 dias de armazenamento a 4ºC. O nível de CS não afetou a umidade, os teores de gordura, proteína total e cinzas, os níveis de bactérias mesófilas e psicrotróficas, e os parâmetros sensoriais do queijo Mussarela. Entretanto, houve aumento da capacidade de derretimento no queijo fabricado com leite de alta CCS. Os resultados indicam que o leite cru utilizado para a produção de queijo Mussarela não deve conter níveis de CS acima de 800.000/mL, para evitar alterações nas propriedades funcionais do queijo Mussarela.

  7. Statistical analysis of wind speed using two-parameter Weibull distribution in Alaçatı region

    International Nuclear Information System (INIS)

    Ozay, Can; Celiktas, Melih Soner

    2016-01-01

    Highlights: • Wind speed & direction data from September 2008 to March 2014 has been analyzed. • Mean wind speed for the whole data set has been found to be 8.11 m/s. • Highest wind speed is observed in July with a monthly mean value of 9.10 m/s. • Wind speed with the most energy has been calculated as 12.77 m/s. • Observed data has been fit to a Weibull distribution and k &c parameters have been calculated as 2.05 and 9.16. - Abstract: Weibull Statistical Distribution is a common method for analyzing wind speed measurements and determining wind energy potential. Weibull probability density function can be used to forecast wind speed, wind density and wind energy potential. In this study a two-parameter Weibull statistical distribution is used to analyze the wind characteristics of Alaçatı region, located in Çeşme, İzmir. The data used in the density function are acquired from a wind measurement station in Alaçatı. Measurements were gathered on three different heights respectively 70, 50 and 30 m between 10 min intervals for five and half years. As a result of this study; wind speed frequency distribution, wind direction trends, mean wind speed, and the shape and the scale (k&c) Weibull parameters have been calculated for the region. Mean wind speed for the entirety of the data set is found to be 8.11 m/s. k&c parameters are found as 2.05 and 9.16 in relative order. Wind direction analysis along with a wind rose graph for the region is also provided with the study. Analysis suggests that higher wind speeds which range from 6–12 m/s are prevalent between the sectors 340–360°. Lower wind speeds, from 3 to 6 m/s occur between sectors 10–29°. Results of this study contribute to the general knowledge about the regions wind energy potential and can be used as a source for investors and academics.

  8. Composição bromatológica e produtividade do capim-andropógon em diferentes idades de rebrota em sistema silvipastoril - DOI: 10.4025/actascianimsci.v31i2. Bromatological composition and productivity of Andropogon grass at different ages of resprout in silvopastoral system - DOI: 10.4025/actascianimsci.v31i2.4549

    Directory of Open Access Journals (Sweden)

    Teodoreto Barbosa Carvalho

    2009-08-01

    Full Text Available Avaliou-se a composição e produtividade do capim-andropógon (Andropogon gayanus Kunth. em diferentes idades de rebrota, associado às espécies arbóreas pau-d’arco (Tabebuia serratifolia e jatobá (Hymenaea courbaril no período chuvoso, em Teresina, Piauí. Adotou-se o delineamento de blocos ao acaso, em esquema fatorial 3 x 2, com parcelas subdivididas, sendo as parcelas os ambientes (sombreamento com jatobá e pau-d’arco e área aberta e posições (nascente e poente, e as subparcelas as idades (35, 49 e 63 dias, com cinco repetições. Houve interação ambiente x idade para MS na planta, FDN e FDA na planta e nas folhas e NIDN nas folhas. A PB nas folhas à sombra foi superior (9,65 ± 0,94% em relação à área aberta (9,16 ± 1,41%. Houve efeito linear decrescente (p The study evaluated composition and productivity of Andropogon grass at different ages of resprout, associated with the species Tabebuia serratifolia and Hymenaea courbaril, during the rainy period, in Teresina, Piauí. A random blocks design was adopted, in a 3 x 2 factorial scheme, with subdivided parcels, being the parcels the environments (shading with Tabebuia serratifolia, Hymenaea courbaril and open area and position (rising and setting, and subparcels the ages (35, 49 and 63 days, with five repetitions. There was interaction between the environment and age for DM in the plant, NDF and ADF in the plant and leaves, and NDIN in leaves. The CP in leaves in the shade was higher (9.65 ± 0.94% compared to the open area (9.16 ± 1.41%. There was a linear effect (p Andropogon grass under T. serratifolia and H. courbaril, respectively. The culture of the grass in silvopastoral systems is viable, due to the stability in the composition of DM and ADF in the ratios of NDIN and ADIN in the plant and leaves, as well as for CP in plant and NDF in leaves, with higher CP levels in leaves of the grass. There was no difference in the levels of NDF in the grass in function of

  9. Composição bromatológica e produtividade do capim-andropógon em diferentes idades de rebrota em sistema silvipastoril = Bromatological composition and productivity of Andropogon grass at different ages of resprout in silvopastoral system

    Directory of Open Access Journals (Sweden)

    Marlúcia da Silva Bezerra Lacerda

    2009-04-01

    Full Text Available Avaliou-se a composição e produtividade do capim-andropógon (Andropogon gayanus Kunth. em diferentes idades de rebrota, associado às espécies arbóreas pau-d’arco (Tabebuia serratifolia e jatobá (Hymenaea courbaril no período chuvoso, em Teresina, Piauí.Adotou-se o delineamento de blocos ao acaso, em esquema fatorial 3 x 2, com parcelas subdivididas, sendo as parcelas os ambientes (sombreamento com jatobá e pau-d’arco e área aberta e posições (nascente e poente, e as subparcelas as idades (35, 49 e 63 dias, com cinco repetições. Houve interação ambiente x idade para MS na planta, FDN e FDA na planta e nas folhas e NIDN nas folhas. A PB nas folhas à sombra foi superior (9,65 ± 0,94% em relação à área aberta (9,16 ± 1,41%. Houve efeito linear decrescente (p The study evaluated composition and productivity of Andropogon grass at different ages of resprout, associated with the species Tabebuiaserratifolia and Hymenaea courbaril, during the rainy period, in Teresina, Piauí. A random blocks design was adopted, in a 3 x 2 factorial scheme, with subdivided parcels, being the parcels theenvironments (shading with Tabebuia serratifolia, Hymenaea courbaril and open area and position (rising and setting, and subparcels the ages (35, 49 and 63 days, with five repetitions. There wasinteraction between the environment and age for DM in the plant, NDF and ADF in the plant and leaves, and NDIN in leaves. The CP in leaves in the shade was higher (9.65 ± 0.94% compared to the open area (9.16 ± 1.41%. There was a linear effect (p < 0.01 of the age on CPin the plant and leaves. From days 47.7 and 48.8 there was a reduction in the leaf/steam ratio of Andropogon grass under T. serratifolia and H. courbaril, respectively. The culture of the grass in silvopastoral systems is viable, due to the stability in the composition of DM and ADF in the ratios of NDIN and ADIN in the plant and leaves, as well as for CP in plant and NDF in leaves, with

  10. Maternal perception of their child's nutritional status at less than three years old.

    Science.gov (United States)

    Duarte, Luciane Simões; Fujimori, Elizabeth; Toriyama, Áurea Tamami Minagawa; Palombo, Claudia Nery Teixeira; Miranda, Patrícia Pereira Lima; Borges, Ana Luiza Vilela

    2016-01-01

    Assessing maternal perception of their children's nutritional status and identifying associated factors. A cross-sectional study conducted in a small municipality with 342 children less than 3 years of age treated in Basic Health Units of São Paulo. Nutritional status was classified in percentiles of body mass index for age and maternal perception was assessed using the scale of verbal descriptors (very thin, thin, healthy weight, fat, very fat). Logistic regression was used to identify the associatedfactors. 44.7% of maternal perception was found to beinadequate. Mothers of overweight (OR = 11.8, 95% CI: 6.4-21.7) and underweight (OR = 5.5; 95% CI: 1.9-16.2) children had a higher chance of having inadequate perception, similar to mothers of children over 24 months of age (OR = 2.9; 95% CI: 1.4-6.0). For effective child care in primary care, healthcare professionals should consider maternal perception and helpmothers to identify the nutritional status of children in childcare consultations and growth monitoring. Avaliar a percepção materna do estado nutricional do filho e identificar os fatores associados. Estudo transversal realizado em município de pequeno porte com 342 crianças menores de 3anos atendidas em Unidades Básicas de Saúde do Estado de São Paulo. O estado nutricional foi classificado em percentis do Índice de Massa Corporalpara Idade e a percepção materna foi avaliada com escala de descritores verbais (muito magro, magro, peso adequado, gordo, muito gordo). Utilizou-se de regressão logística para identificar os fatores associados. Constatou-se 44,7% de percepção materna inadequada. Mães de crianças com excesso de peso (OR=11,8; IC95%:6,4-21,7) e com baixo peso (OR=5,5; IC95%:1,9-16,2) apresentaram mais chance de percepção inadequada, da mesma forma que mães de crianças com mais de 24 meses de idade (OR=2,9; IC95%:1,4-6,0). Para uma efetiva assistência à criança na atenção básica, profissionais de saúde devem considerar a

  11. The development and refinement of models of less established and more established high school environmental service-learning programs in Florida

    Science.gov (United States)

    Malikova, Yuliya

    2005-07-01

    Environmental Service-Learning (Env. S-L) appears to show great promise and practitioners tout its benefits, although there have been fewer than ten studies in this emerging area of environmental education. The overall study purpose was to describe the nature, status, and effects of Grade 9--16 Env. S-L programs in Florida, and develop descriptive models of those programs. The purpose of Phase I was to describe these programs and associated partnerships. Based on Phase I results, the purpose of Phase II was to develop, compare, and refine models for less and more established high school programs. This study involved: (1) defining the population of Florida 9--16 Env. S-L programs (Phase I); (2) developing and administering program surveys (Phase I, quantitative); (3) analyzing Phase I survey data and identifications of options for Phase II (Intermediate stage); (4) designing and implementing methodology for further data collection (Phase II, qualitative); (5) refining and finalizing program models (Phase II, descriptive); and (6) summarizing program data, changes, and comparisons. This study revealed that Env. S-L has been practiced in a variety of ways at the high school and college levels in Florida. There, the number of high school programs, and participating teachers and students has been growing. Among others, major program features include block scheduling, indirect S-L activities, external funding sources, and formal and ongoing community partnerships. Findings based on self-reported program assessment results indicate that S-L has had positive effects on students across Furco's S-L outcome domains (i.e., academic achievement/success, school participation/behavior, carrier development, personal development, interpersonal development, ethical/moral development, and development of civic responsibility). Differences existed between less established and more established Env. S-L programs. Less established programs had relatively few participating teachers

  12. Effects of dietary amylose/amylopectin ratio on growth performance, feed utilization, digestive enzymes, and postprandial metabolic responses in juvenile obscure puffer Takifugu obscurus.

    Science.gov (United States)

    Liu, Xiang-he; Ye, Chao-xia; Ye, Ji-dan; Shen, Bi-duan; Wang, Chun-yan; Wang, An-li

    2014-10-01

    The effect of dietary amylose/amylopectin (AM/AP) ratio on growth, feed utilization, digestive enzyme activities, plasma parameters, and postprandial blood glucose responses was evaluated in juvenile obscure puffer, Takifugu obscurus. Five isonitrogenous (430 g kg(-1) crude protein) and isolipidic (90 g kg(-1) crude lipid) diets containing an equal starch level (250 g kg(-1) starch) with different AM/AP ratio diets of 0/25, 3/22, 6/19, 9/16 and 12/13 were formulated. Each experimental diet was fed to triplicate groups (25 fish per tank), twice daily during a period of 60 days. After the growth trial, a postprandial blood response test was carried out. Fish fed diet 6/19 showed best growth, feed efficiency and protein efficiency ratio. Hepatosomatic index, plasma total cholesterol concentration, liver glycogen and lipid content, and gluconokinase, pyruvate kinase and fructose-1,6-bisphosphatase activities were lower in fish fed highest AM/AP diet (12/13) than in fish fed the low-amylose diets. Activities of liver and intestinal trypsin in fish fed diet 3/22 and diet 6/19 were higher than in fish fed diet 9/16 and diet 12/13. Activities of liver and intestinal amylase and intestinal lipase, and starch digestibility were negatively correlated with dietary AM/AP ratio. Fish fed diet 3/22 and diet 6/19 showed higher plasma total amino acid concentration than fish fed the other diets, while plasma urea nitrogen concentration and activities of alanine aminotransferase and aspartate aminotransferase showed the opposite trend. Equal values were found for viscerosomatic index and condition factor, whole body and muscle composition, plasma high-density and low-density lipoprotein cholesterol concentrations, and activities of lipase and hexokinase and glucose-6-phosphatase in liver. Postprandial plasma glucose and triglyceride peak value of fish fed diet 12/13 were lower than in fish fed the low-amylose diets, and the peak time of plasma glucose was later than in fish fed the

  13. [Workplace violence in the healthcare sector: the experience of State health employees in Bahia State, Brazil].

    Science.gov (United States)

    Silva, Iracema Viterbo; Aquino, Estela M L; Pinto, Isabela Cardoso de Matos

    2014-10-01

    This study aimed to estimate the prevalence of self-reported violence suffered by healthcare workers, using a cross-sectional design with a sample of 679 State health employees through face-to-face interviews and a questionnaire. Of the respondents, 25.9% (95%CI: 22.6%-29.2%) reported having suffered at least one form of violence, with verbal aggression as the most frequent (19.4%). Women aged 25-39 suffered 80% more violence than older women (OR = 1.8; 95%CI: 1.1-3.0). Female physicians were the most frequently affected group (OR = 2.5; 95%CI: 1.2-12.5). Among men, a nearly fourfold increase in healthcare workplace violence was associated with age 25 to 39 years (OR = 3.9; 95%CI: 1.9-16.4) and nurse assistants or nurse technicians (PR = 3.9; 95%CI: 1.1-13.2). This study can help raise awareness concerning healthcare workplace violence and support policies for health workers' care, with repercussions on quality of care for health services users.

  14. Failure to detect variant (CRM+) plasma thromboplastin antecedent (factor XI) molecules in hereditary plasma thromboplastin antecedent deficiency: a study of 125 patients of several ethnic backgrounds.

    Science.gov (United States)

    Saito, H; Ratnoff, O D; Bouma, B N; Seligsohn, U

    1985-12-01

    Plasma samples of 125 patients from 80 kindreds with hereditary plasma thromboplastin antecedent (PTA, factor XI) deficiency were tested by factor XI radioimmunoassay (RIA) and electroimmunoassay (EIA) in an attempt to detect variant molecules. Ninety-six patients (70 kindreds) were Jewish, and 29 (10 kindreds) were of other ethnic backgrounds, namely, Japanese, black American, Korean, Arab, Indian, and English. Seventy-eight patients were homozygotes, and 47 were heterozygotes. Both non-Jewish homozygotes and heterozygotes had lower factor XI activity than respective Jewish subjects. Twenty-eight homozygotes whose factor XI clotting activities (XI:C) were 1.5% to 13% had factor XI-related antigen (XI:RAG) levels less than 10% by EIA. In 72 homozygotes, including 22 patients who were also tested with EIA, XI:C was 2.9% +/- 3.0% (mean +/- SD) and XI:RAG tested by RIA, 2.9% +/- 3.0%. In 47 heterozygotes, XI:C and XI:RAG tested by RIA were 51.9% +/- 16.6% and 51.0% +/- 16.2%, respectively. Similar results were obtained when only unrelated patients (62 homozygotes and 27 heterozygotes) were analyzed. There was a highly significant correlation between XI:C and XI:RAG (RIA) in 38 homozygotes and 47 heterozygotes (r = 0.94, n = 85, P less than 0.001). Thus, we failed to identify functionally abnormal factor XI molecules (CRM+ variant) in these patients with hereditary factor XI deficiency.

  15. Concentrações bioquímicas séricas de jacaré-açú (Melanosuchus niger machos, adultos de vida livre

    Directory of Open Access Journals (Sweden)

    Bruno Tolentino Caixeta

    2015-12-01

    Full Text Available Resumo: O jacaré-açu (Melanosuchus niger, pertencendo à família Aligatoridae, é considerado o maior predador aquático da América Continental. Como todos os répteis, possui particularidades para o uso de energia, controlando sua temperatura corporal nas variações climáticas. Essas variações podem revelar a situação metabólica atual desse animal, justificando o estudo de tais parâmetros. A importância desse trabalho se justifica pela escassez de estudos disponíveis na literatura. Nesse sentido, determinamos o perfil bioquímico de compostos sanguíneos de 12 jacarés açu, com peso de 77,66±8,92 kg, os quais foram: uréia (3,41±0,66, albumina (24,85±0,63, proteína total (63,83±16,97, ácido úrico (0,25±0,09, glicose (6,99±0,77, colesterol total (2,20±0,27, triglicérides (0,58±0,07, TGO (138,83±9,16 e TGP (12,47±2,82.

  16. A new species of Cystoisospora Frenkel, 1977 (Apicomplexa: Sarcocystidae) from Oecomys mamorae Thomas (Rodentia: Cricetidae) in the Brazilian Pantanal.

    Science.gov (United States)

    Barreto, Wanessa Teixeira Gomes; de Andrade, Gisele Braziliano; Viana, Lúcio André; de Oliveira Porfírio, Grasiela Edith; Santos, Filipe Martins; Perdomo, Alessandra Cabral; do Carmo, Jéssica Soares; da Silva, Alanderson Rodrigues; Maltezo, Taynara Rocha; Herrera, Heitor Miraglia

    2018-03-16

    Despite the great diversity of coccidians, to our knowledge, no coccidian infections have been described in Oecomys spp. In this context, we examined Oecomys mamorae Thomas (Rodentia: Cricetidae) from the Brazilian Pantanal for infections with enteric coccidia. Nine individuals were sampled, and one was found to be infected. The oöcysts were recovered through centrifugal flotation in sugar solution. Using morphological and morphometric features, we described a new species of Cystoisospora Frenkel, 1977. Sporulated oöcysts were ovoidal 20.0-29.1 × 16.4-23.2 (26.7 × 21.2) µm and contained two sporocysts, 12.9-19.1 × 9.4-13.9 (16.4 × 12.4) µm, each with four banana-shaped sporozoites. Polar granule and oöcyst residuum were both absent. We documented the developmental forms in the small intestine and described the histopathological lesions in the enteric tract. Our results indicate that the prevalence of Cystoisospora mamorae n. sp. in O. mamorae is low, and tissue damage in the enteric tract is mild, even in the presence of coccidian developmental stages.

  17. A fizzy environment: availability and consumption of sugar-sweetened beverages among school students.

    Science.gov (United States)

    Hebden, Lana; Hector, Debra; Hardy, Louise L; King, Lesley

    2013-06-01

    Reducing sugar-sweetened beverage (SSB) consumption has been targeted in obesity prevention strategies internationally. This study examined associations between SSB availability at school and in the home, and consumption among Australian school students. Secondary analysis of the 2010 New South Wales Schools Physical Activity and Nutrition Survey (n=8058) was conducted. Logistic regression analyses tested the impact of SSB availability at school and in the home on consumption category (low, ≤1 cup/week; moderate, 2-4 cups/week; high, ≥5 cups/week). Students in years K-10 (ages 4-16years) who usually purchased sugar-sweetened soft drinks or sports drinks from their school canteen were almost three times as likely to be high consumers (AOR 2.90; 95%CI 2.26, 3.73). Students in years 6-10 (ages 9-16years) were almost five times as likely to be high consumers if soft drinks were usually available in their home (AOR 4.63; 95%CI 3.48, 6.17), and almost ten times as likely to be high consumers if soft drinks were usually consumed with meals at home (AOR 9.83; 95%CI 6.06, 15.96). Limiting the availability of SSBs in the home and school environments is a prudent response to address high SSB consumption among school students, albeit only part of the solution for obesity prevention. Copyright © 2013 Elsevier Inc. All rights reserved.

  18. Nonurban aerosol composition near Beijing, China

    International Nuclear Information System (INIS)

    Winchester, J.W.; Darzi, M.; Leslie, A.C.D.; Wang, M.; Ren, L.; Lue, W.; Hansson, H.C.; Lannefors, H.

    1981-01-01

    The urban aerosol plume of Beijing has been sampled as a function of particle size and time at a site 110 km NE of the city, 9-16 March 1980, during the season for space heating by coal combustion. A fine particle mode, contained mostly in the 0.5-2 μm aerodynamic diameter range, could be distinguished from a coarse mode of dust having terrestrial composition by reference to the size distribution of Ca. Elemental composition determined by PIXE analysis for 17 elements, including S and heavy metals, indicates fine mode concentrations higher than background aerosol but with a similarity to cleaner air with respect to both relative elemental abundances and elemental particle size distributions. The results indicate that elements contained in aged coal combustion aerosol occur mainly in 0.5-2 μMAD particles, not smaller, and the aerosol is not substantially different from background aerosol except in overall concentrations. This result may simplify the prediction of the impact of coal combustion on air quality. The results also hint that the background aerosol in more remote continental areas may also be combustion derived. (orig.)

  19. Magnetic resonance imaging (MRI) of liver and brain in haematologic-organic patients with fever of unknown origin

    International Nuclear Information System (INIS)

    Heussel, C.P.; Kauczor, H.U.; Poguntke, M.; Schadmand-Fischer, S.; Mildenberger, P.; Thelen, M.; Heussel, G.

    1998-01-01

    To examine the advantage of liver and brain MRI in clinically anomalous haematological patients with fever of unknown origin. Material and Methods: Twenty liver MRI (T 2 -TSE, T 2 -HASTE, T 1 -FLASH±Gd dynamic) and 16 brain MRI (T 2 -TSE, FLAIR, T 1 -TSE±Gd) were performed searching for a focus of fever with a suspected organ system. Comparison with clinical follow-up. Results: suspected organ system. Comparison with clinical follow-up. Results: A focus was detected in 11/20 liver MRI. Candidiasis (n=3), mycobacteriosis (n=2), relapse of haematological disease (n=3), graft versus host disease (n=1), non-clarified (n=2). The remaining 9 cases with normal MRI were not suspicious of infectious hepatic disease during follo-wup. In brain MRI, 3/16 showed a focus (toxoplasmosis, aspergillosis, mastoiditis). Clinical indication for an infectious involvement of the brain was found in 4/16 cases 2--5 months after initially normal brain MRI. No suspicion of an infectious involvement of brain was present in the remaining 9/16 cases. Conclusion: In case of fever of unknown origin and suspicion of liver involvement, MRI of the liver should be performed due to data given in literature and its sensitivity of 100%. Because of the delayed detectability of cerebral manifestations, in cases of persisting suspicion even a previously normal MRI of the brain should be repeated. (orig.) [de

  20. C-reactive protein--can it be used as a marker of infection in patients with exacerbation of chronic obstructive pulmonary disease?

    DEFF Research Database (Denmark)

    Weis, Nina; Almdal, Thomas Peter; Almdal, Thomas

    2006-01-01

    BACKGROUND: Far from all patients with exacerbation of chronic obstructive pulmonary disease (COPD) benefit from antibiotic treatment. However, as these patients are often colonized with bacteria, even in a stable phase, there is no reliable method for establishing whether the patients have...... for determination of white blood cell count and CRP, and a chest X-ray was taken. Patients whose X-rays of the thorax showed changes compatible with pneumonia were considered to have pneumonia of bacterial origin. RESULTS: Pneumonia was diagnosed in 51 patients. Their median CRP was 97 mg/l (49-145 interquartile...... range). Among patients without pneumonia, 46% (51/115) had normal CRP values (0-10 mg/l); 64 had no increased sputum purulence and a median CRP of 8 mg/l (2.9-16 mg/l), which is significantly lower than in the 51 patients who reported increased sputum purulence and had a CRP of 45 mg/l (8.5-86 mg/l; p

  1. Radiofrequency ablation of chondroblastoma: procedure technique, clinical and MR imaging follow up of four cases

    Energy Technology Data Exchange (ETDEWEB)

    Christie-Large, M.; Evans, N.; Davies, A.M.; James, S.L.J. [Royal Orthopaedic Hospital Foundation Trust, Department of Radiology, Birmingham (United Kingdom)

    2008-11-15

    The aim of this study is to describe the procedure technique, clinical and imaging outcomes of patients treated with radiofrequency ablation for chondroblastoma. Four patients (female/male, 3:1; mean age, 13 years; age range; 9-16 years) underwent the procedure. All had pre-operative magnetic resonance imaging (MRI) and symptomatic, biopsy-proven chondroblastomas (two proximal femur, two proximal tibia). The lesion size ranged from 1.5 to 2.5 cm in maximal dimension (mean size, 1.8 cm). Bone access was gained with a Bonopty biopsy needle system (mean number of radiofrequency needle placements, 5; mean ablation time, 31 min). Clinical and MRI follow-up was available in all cases (mean, 12.25 months; range, 5-18 months). All patients reported resolution of symptoms at 2-6 weeks post ablation. At their most recent clinical follow-up, three patients remained completely asymptomatic with full return to normal activities and one patient had minor local discomfort (different pain pattern) that was not limiting activity. All four patients' follow-up MRI studies demonstrated resolution of the oedema pattern around the lesion and temporal evolution of the internal signal characteristics with fatty replacement. Radiofrequency ablation for chondroblastoma provides an alternative to surgical curettage, and we have demonstrated both a clinical improvement in symptoms and the follow-up MRI appearances. (orig.)

  2. Análise de metais pesados em amostras de Peumus boldus Mol. (Monimiaceae

    Directory of Open Access Journals (Sweden)

    Melissa Schwanz

    Full Text Available Oito amostras, provenientes do Brasil, Chile e Argentina, de Peumus boldus Molina (Monimiaceae, espécie comum e abundante no Chile, cujas folhas são amplamente empregadas pela medicina tradicional para o tratamento de uma variedade de afecções do sistema digestivo e hepatobiliar, foram analisadas, após digestão nítrica, para a quantificação de ferro, manganês, cobre, chumbo, cromo, cobalto e níquel, por espectrofotometria de absorção atômica. Chumbo, cromo e cobalto não foram detectados (limite de detecção de 5 µg/g em nenhuma das amostras. Todas as amostras apresentaram maior teor em ferro, que variou de 109,7 mg/kg a 315,7 mg/kg, seguido por manganês (65,5 mg/kg a 158,8 mg/kg, cobre (3,04 mg/kg a 9,16 mg/kg e níquel (0,77 mg/kg a 4,31 mg/kg.

  3. Association between trichodiniasis in eel ( Anguilla anguilla ) and water quality in recirculation systems

    DEFF Research Database (Denmark)

    Madsen, H.C.K.; Buchmann, K.; Mellergaard, Stig

    2000-01-01

    Association between various water quality parameters and the infection level of Trichodina jadranica in cultured eels were examined in nine recirculation farms in Denmark. Production units suffering from trichodiniasis (n = 4) had relatively high contents of organic dry matter (13-65 mg l(-1)), low...... concentrations of nitrate (150-500 mg NO3 l(-1)) and high pH (6.2-7.4) in the process water compared to farms without Trichodina problems (n = 5), which had a relatively low load of organic dry matter (9-16 mg l(-1)), high nitrate concentration (250-900 mg NO3 l(-1)) and a low pH (5.3-6.9). More detailed studies...... of the effect of water parameters on the infection level were conducted in two production units suffering from frequent outbreaks of trichodiniasis. In one production unit, the high and highly varying content of organic dry matter (21- 83 mg l(-1)) was significantly and positively correlated (r = 0.37, p

  4. Characteristics of the Triassic Source Rocks of the Aitutu Formation in the (West Timor Basin

    Directory of Open Access Journals (Sweden)

    Asep Kurnia Permana

    2014-12-01

    Full Text Available DOI:10.17014/ijog.v1i3.192The Triassic rocks of the (West Timor Basin have been identified that was mainly deposited in the  marine environment. The fine grained clastics and carbonate  rocks of this Triassic marine  facies are considered to be the most promising source rocks potential in this basin. In this paper we present geochemical and petrographic data from outcrop samples of the Triassic carbonate Aitutu Formation, due to emphasized the organic maturation, kerogen type of the organic matter and the origin of the organic matter.  A representative of selected sample were subjected to the Rock-Eval Pyrolisis, vitrinite reflectance and thermal alteration index, bitumen extraction, were analyzed on the GC-MS. The samples were collected from marine deposit of the Triassic Sequence. The TOC values of the analyzed sample range between rich and rich organic richness (0.51% - 9.16%, wt.%, TOC, which consists mainly of type II and III kerogen and the organic matter consider to be predominantly oil/gas prone and gas prone potential. The thermal maturity assessed from Tmax, TAI, and vitrinite reflectance shows an immature to early peak mature stage of the organic matter. The GC-MS analyses of the biomarkers indicate mainly the organic matter derived from mixed source rocks facies containing alga debris and higher plant terrestrial origin.

  5. Phenotypic and genetic characterization of clinical isolates of CDC coryneform group A-3: proposal of a new species of Cellulomonas, Cellulomonas denverensis sp. nov.

    Science.gov (United States)

    Brown, June M; Frazier, Rodrick P; Morey, Roger E; Steigerwalt, Arnold G; Pellegrini, Gerald J; Daneshvar, Maryam I; Hollis, Dannie G; McNeil, Michael M

    2005-04-01

    CDC coryneform group A-3 bacteria are rare human pathogens. In this study, six group A-3 isolates (two from blood, one from cerebrospinal fluid, and one each from homograft valve, lip wound, and pilonidal cyst) were compared to the type strains of phenotypically related organisms, Cellulomonas fimi, Cellulomonas hominis, Oerskovia turbata, and Sanguibacter suarezii, and characterized by phenotypic, chemotaxonomic, and genotypic studies. DNA-DNA reassociation analysis identified two genomic groups, and phylogenetic analysis of the 16S rRNA gene sequence identified the taxonomic positions of these groups to genus level. Two groups were defined, and both were more closely related to Cellulomonas species: one group of three strains, for which we propose the new species Cellulomonas denverensis sp. nov., with the type strain W6929 (ATCC BAA-788(T) or DSM 15764(T)), was related to C. hominis ATCC 51964(T) (98.5% 16S rRNA gene sequence similarity), and the second group of three strains was related to C. hominis ATCC 51964(T) (99.8 to 99.9% 16S rRNA gene sequence similarity). The definition of this new Cellulomonas species and the confirmation of three strains as C. hominis serve to further clarify the complex taxonomy of CDC coryneform group A-3 bacteria and will assist in our understanding of the epidemiology and clinical significance of these microorganisms.

  6. Risk Factors for Pneumonia in Ventilated Trauma Patients with Multiple Rib Fractures

    Directory of Open Access Journals (Sweden)

    Hyun Oh Park

    2017-10-01

    Full Text Available Background: Ventilator-associated pneumonia (VAP is a common disease that may contribute to morbidity and mortality among trauma patients in the intensive care unit (ICU. This study evaluated the associations between trauma factors and the development of VAP in ventilated patients with multiple rib fractures. Methods: We retrospectively and consecutively evaluated 101 patients with multiple rib fractures who were ventilated and managed at our hospital between January 2010 and December 2015, analyzing the associations between VAP and trauma factors in these patients. Trauma factors included sternal fracture, flail chest, diaphragm injury, traumatic aortic dissection, combined cardiac injury, pulmonary contusion, pneumothorax, hemothorax, hemopneumothorax, abbreviated injury scale score, thoracic trauma severity score, and injury severity score. Results: Forty-six patients (45.5% had at least 1 episode of VAP, 10 (21.7% of whom died in the ICU. Of the 55 (54.5% patients who did not have pneumonia, 9 (16.4% died in the ICU. Using logistic regression analysis, we found that VAP was associated with severe lung contusion (odds ratio, 3.07; 95% confidence interval, 1.12 to 8.39; p=0.029. Conclusion: Severe pulmonary contusion (pulmonary lung contusion score 6–12 is an independent risk factor for VAP in ventilated trauma patients with multiple rib fractures.

  7. Quinone/hydroquinone meroterpenoids with antitubercular and cytotoxic activities produced by the sponge-derived fungus Gliomastix sp. ZSDS1-F7.

    Science.gov (United States)

    He, Wei-Jun; Zhou, Xiao-Jiang; Qin, Xiao-Chu; Mai, Yong-Xin; Lin, Xiu-Ping; Liao, Sheng-Rong; Yang, Bin; Zhang, Tianyu; Tu, Zheng-Chao; Wang, Jun-Feng; Liu, Yonghong

    2017-03-01

    Fifteen compounds, including six quinone/hydroquinone meroterpenoids, purpurogemutantin (1), macrophorin A (2), 4'-oxomacrophorin (3), 7-deacetoxyyanuthone A (4), 2,3-hydro-deacetoxyyanuthone A (5), 22-deacetylyanuthone A (6), anicequol (7), three roquefortine derivatives, roquefortine C (8), (16S)-hydroxyroquefortine C (9), (16R)-hydroxyroquefortine C (10), dihydroresorcylide (11), nectriapyrone (12), together with three fatty acid derivatives, methyl linoleate (13), phospholipase A 2 (14), methyl elaidate (15), were isolated from the sponge-derived fungus Gliomastix sp. ZSDS1-F7 isolated from the sponge Phakellia fusca Thiele collected in the Yongxing island of Xisha. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analyses. Among these compounds, compounds 1-3 and 5-7 showed significant in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4 and HL60 cell lines, with IC 50 values ranging from 0.19 to 35.4 μM. And compounds 2-4 exhibited antitubercular activity with IC 50 values of 22.1, 2.44 and 17.5 μM, respectively. Furthermore, compound 7 had anti-enterovirus 71 activity with MIC value of 17.8 μM. To the best of our knowledge, this is the first report to product two quinone/hydroquinone meroterpenoids skeletons (linear skeleton and drimane skeleton) from the same fungal strain.

  8. Anxiety, depression and self-esteem levels in obese children: a case-control study.

    Science.gov (United States)

    Topçu, Seda; Orhon, Filiz Şimşek; Tayfun, Meltem; Uçaktürk, Seyit Ahmet; Demirel, Fatma

    2016-03-01

    Obesity is a global health problem affecting all age groups. Childhood obesity, which may cause chronic diseases including diabetes mellitus, cardiovascular disease and cancer, etc., deserves more attention. However, few studies highlight the association between childhood obesity and psychological diseases. In the present study, we aimed to evaluate the psychological condition in obese children. One hundred and sixty-seven obese (body mass index (BMI) >95th percentile) and 200 normal weight children (BMI between 5th and 85th percentile) aged 9-16 years were enrolled into this case-control study. In order to assess the self-concept, anxiety and depression levels: the Piers-Harris Children's Self-Concept Scale (PHCSCS), state and trait anxiety inventory for children (STAI-C) and the children depression inventory (CDI) were administered both obese and control groups. There were significant differences among obese and control groups in terms of the total score of PHCSCS [55 (22-69) versus 65 (57-74)], STAI-C [37 (20-55) versus 28 (20-42)], and CDI [12 (4-39)] versus [8 (3-19)]; respectively (p<0.001, p<0.001, p<0.001). We also found statistically significant differences among groups in all of the subscales parameters of PHCSCS (p<0.001). Our results indicate that obese children may experience psychiatric disorders more than normal-weight peers.

  9. Clinical and economic consequences of treating patients with peripheral neuropathic pain with brand name or generic drugs in routine clinical practice: The effects of age and sex.

    Science.gov (United States)

    Navarro-Artieda, R; Rejas-Gutiérrez, J; Pérez-Paramo, M; Sicras-Mainar, A

    2018-04-01

    We aimed to analyse the effects of age and sex on pain and cost for patients with chronic peripheral neuropathic pain (PNP) who have started treatment with brand name gabapentin versus generic gabapentin (EFG). We conducted a retrospective multicentre study using electronic medical records (EMR) for patients of both sexes, older than 18, who began treatment with brand name or generic gabapentin. Adherence (medication possession ratio [MPR]), persistence, use of healthcare resources, cost, and pain reduction were measured for one year. We analysed 1369 EMRs [61.1% women; mean age 64.6 (15.9), 52.4%≥65 years]; 400 used brand name drugs while 969 used generic gabapentin. Persistence and adherence were higher in patients using brand name gabapentin (7.3 vs 6.3 months, Pbrand-name gabapentin in both age groups (brand treatment showed greater pain relief: 13.5% (10.9-16.2) and 10.8% (8.2-13.5) in brand name medication showed greater persistence and adherence to treatment than those taking generic drugs. Brand name treatment also involved lower healthcare costs, and greater pain relief. Copyright © 2016 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

  10. Introducing random safety audits (RSA) in a neonatal intensive care unit (NICU).

    LENUS (Irish Health Repository)

    Szymanska, M

    2012-01-31

    Random safety audits (RSA) have been shown to be effective in improving standards of clinical practice. 19 data collection audits were performed relating to hygiene, safe prescribing, oxygen pulse oximetry monitoring and documentation in keeping with the requirements of the new Medical Practitioners Act (MPA) 2007. Hygiene audits (range from 20\\/25 to 21\\/21 80%-100%) and safe prescribing audits (range from 23\\/25 to 25\\/25 86%-100%) achieved n=25 100% compliance with unit guidelines over a 3 month period. Compliance with oxygen pulse oximetry monitoring guideline limits improved from 4\\/27 (15%) to 9\\/16 (56%). Compliance with requirement and use of Physician IMC registration number in documentation was only 10\\/18 (56%). RSA\\'s led to improvements in hygiene and prescribing. Compliance with oxygen monitoring guideline limits highlighted the need for greater education. Awareness of legal requirements relating to documentation improved but this has not translated into a change in practice. RSA\\'s can facilitate real time quality improvement in daily clinical practice.

  11. Levels of platelet-derived microparticles and soluble p-selectin in patients of acute myocardial infarction (case control study).

    Science.gov (United States)

    Hameed, Aisha; Rubab, Zille; Abbas Rizvi, Syed Khizar; Hussain, Shabbir; Latif, Waqas; Mohsin, Shahida

    2017-07-01

    TTo measure levels of platelet-derived microparticles and soluble P-selectin in patients of acute myocardial infarction and their comparison with healthy controls. This case-control study was conducted in Department of Haematology, University of Health Sciences Lahore from April to September 2013, and comprised patients of acute myocardial infarction in group 1 and healthy controls in group 2. Platelet-derived microparticles and soluble P-selectin were measured by enzyme-linked immunosorbent assay. SPSS21 was used for data analysis. Of the 80 participants, 50(62.5%) were patients and 30(37.5%) were controls. The mean levels of platelet-derived microparticles and soluble P-selectin were significantly higher in group 1 compared to group 2 (45.70±10.30 vs 10.60±0.96, and 51.46±9.30 vs 9.16±1.04, respectively) (pderived microparticles and soluble P-selectin in three intervals after acute myocardial infarction (p>0.05). Although levels of platelet-derived microparticles and soluble P-selectin did not correlate to creatinekinase-myocardial band levels (p>0.05), but there was a trend of significant correlation with cardiac troponin T (pderived microparticles and soluble P-selectin can be used as novel early diagnostic marker of acute myocardial infarction.

  12. Evaluation of cardiac functions in patients with thalassemia major

    International Nuclear Information System (INIS)

    Kucuk, N.O.; Aras, G.; Sipahi, T.; Ibis, E.; Akar, N.; Soylu, A.; Erbay, G.

    1999-01-01

    It is known that a blood transfusion is necessary for survival in patients with thalassemia, but it may cause myocardial dysfunction due to myocardial siderosis as in other organs. The aim of this study was to evaluate myocardial perfusion by means of stress thallium scanning (MPS) and left ventricular functions by rest radionuclide ventriculography (RNV). Twenty-one patients at ages 9-16 (mean 12.1±3.2) who have been diagnosed with thalassemia for 4-15 years mean 12.7±4.8) were included in the study. They had blood transfusion 78-318 times (mean 162.1±71). MPS and RNV was performed within two days after the any transfusion. MPS showed ischemia in 3 patients and normal perfusion in 18 patients. RNV revealed normal systolic parameters (wall motion, EF, PER, TPE) but diminished diastolic parameters (TPF, PFR) compared with normal values (p<0.05). We conclude that ischemia or fixed defects may be seen in stress MPS as results of cardiac involvement in patients with thalassemia. But, RNV is an important and preferable test for the early detection of subclinic cardiomyopathy. RNV may therefore show diastolic abnormalities before the systolic abnormalities show up. (author)

  13. Análisis de la condición física en jóvenes jugadores de fútbol en función de la categoría de formación y del puesto específico

    Directory of Open Access Journals (Sweden)

    Fernando Calahorro Cañada

    2012-09-01

    Full Text Available El objetivo principal de este trabajo es valorar el nivel de condición física en jugadores de 13 a 18 años, determinando posibles diferencias respecto a la categoría de formación (infantil, cadete y juvenil y el puesto específico (porteros, defensas, centrocampistas, delanteros. Se seleccionaron 66 jugadores (con una edad de 15,46 ± 1,83 años, una masa de 63,33 ± 9,51 kg, una estatura de 171,44 ± 8,38 cm y una experiencia previa competitiva de 9,16 ± 1,93 años. Se determinó la composición corporal (INBODY 720, flexibilidad isquiosural (test sit and reach, salto con contramovimiento y abalakov (plataforma nusclelab 4000, y consumo máximo de oxígeno (test de course navette. Se observan diferencias por puesto específico y categoría de formación en la composición corporal y condición física (infantiles respecto cadetes y juveniles, y se observan diferencias fundamentalmente entre los puestos específicos de defensas cadetes respecto a los juveniles, y entre el puesto especifico de categoría infantil respecto al resto.

  14. Ultraviolet-visible study on acid-base equilibria of aporphine alkaloids with antiplasmodial and antioxidant activities from Alseodaphne corneri and Dehaasia longipedicellata

    Science.gov (United States)

    Zahari, Azeana; Ablat, Abdulwali; Omer, Noridayu; Nafiah, Mohd Azlan; Sivasothy, Yasodha; Mohamad, Jamaludin; Khan, Mohammad Niyaz; Awang, Khalijah

    2016-02-01

    The UV-vis spectra of isocorydine 1, norisocorydine 2 and boldine 3 were studied in 2% v/v acetonitrile, at constant ionic strength (0.1 M NaCl, 35 degree Celsius). The pKa values of isocorydine 1 and norisocorydine 2 were 11.75 and 12.07, respectively. Boldine 3 gave a pKa value of 9.16 and 10.44. All of the alkaloids 1-3 were stable at physiological pH; thereby all of them will not ionize, thus permitting the basic nitrogen to be protonated and accumulated within the acidic food vacuole of Plasmodium via pH trapping. Subsequently, acidic food vacuoles that have been neutralized by alkaloids would result in enhancement of the antiplasmodial activity. The alkaloids showed antiplasmodial activity against Plasmodium falciparum and antioxidant activities; DPPH radical scavenging, metal chelating and ferric reducing power. The antioxidant properties of the alkaloids under investigation revealed that in addition to the antiplasmodial activity, the alkaloids can also prevent oxidative damage. It can be prevented by binding free heme and neutralizing the electrons produced during the Plasmodium falciparum mediated haemoglobin destruction in the host. Slightly basic properties of the aforementioned alkaloids, along with their antioxidant activities, are advantageous in improving the suppression of malaria infection that cause less damage to the host.

  15. Streptococcus rupicaprae sp. nov., isolated from a Pyrenean chamois (Rupicapra pyrenaica).

    Science.gov (United States)

    Vela, A I; Mentaberre, G; Marco, I; Velarde, R; Lavín, S; Domínguez, L; Fernández-Garayzábal, J F

    2011-08-01

    Biochemical and molecular genetic studies were performed on an unknown Gram-stain-positive, catalase-negative, coccus-shaped organism isolated from clinical samples of a Pyrenean chamois. The micro-organism was identified as a streptococcal species based on its cellular morphological and biochemical tests. 16S rRNA gene sequence comparison studies confirmed its identification as a member of the genus Streptococcus, but the organism did not correspond to any species of this genus. The nearest phylogenetic relative of the unknown coccus from chamois was Streptococcus ovis (95.9 % 16S rRNA gene sequence similarity). The rpoB and sodA sequence analysis showed sequence similarity values of less than 85.7 % and 83.0 %, respectively, with the currently recognized species of the genus Streptococcus. The novel bacterial isolate was distinguished from S. ovis and other species of the genus Streptococcus using biochemical tests. Based on both phenotypic and phylogenetic findings, it is proposed that the unknown bacterium be classified as a novel species of the genus Streptococcus, Streptococcus rupicaprae sp. nov., with the type strain 2777-2-07(T) ( = CECT 7718(T)  = CCUG 59652(T)).

  16. SU-E-T-335: Transit Dosimetry for Verification of Dose Delivery Using Electronic Portal Imaging Device (EPID)

    Energy Technology Data Exchange (ETDEWEB)

    Baek, T [Korea University, Seoul (Korea, Republic of); National Health Insurance Co.Ilsan Hospital, Ilsan (Korea, Republic of); Chung, E [National Health Insurance Co.Ilsan Hospital, Ilsan (Korea, Republic of); Lee, S [Cheil General Hospital and Women Healthcare Center, Kwandong University, Seoul (Korea, Republic of); Yoon, M [Korea University, Seoul (Korea, Republic of)

    2014-06-01

    Purpose: To evaluate the effectiveness of transit dose, measured with an electronic portal imaging device (EPID), in verifying actual dose delivery to patients. Methods: Plans of 5 patients with lung cancer, who received IMRT treatment, were examined using homogeneous solid water phantom and inhomogeneous anthropomorphic phantom. To simulate error in patient positioning, the anthropomorphic phantom was displaced from 5 mm to 10 mm in the inferior to superior (IS), superior to inferior (SI), left to right (LR), and right to left (RL) directions. The transit dose distribution was measured with EPID and was compared to the planed dose using gamma index. Results: Although the average passing rate based on gamma index (GI) with a 3% dose and a 3 mm distance-to-dose agreement tolerance limit was 94.34 % for the transit dose with homogeneous phantom, it was reduced to 84.63 % for the transit dose with inhomogeneous anthropomorphic phantom. The Result also shows that the setup error of 5mm (10mm) in IS, SI, LR and SI direction can Result in the decrease in values of GI passing rates by 1.3% (3.0%), 2.2% (4.3%), 5.9% (10.9%), and 8.9% (16.3%), respectively. Conclusion: Our feasibility study suggests that the transit dose-based quality assurance may provide information regarding accuracy of dose delivery as well as patient positioning.

  17. Hard and flexible nanocomposite coatings using nanoclay-filled hyperbranched polymers.

    Science.gov (United States)

    Fogelström, Linda; Malmström, Eva; Johansson, Mats; Hult, Anders

    2010-06-01

    The combination of hardness, scratch resistance, and flexibility is a highly desired feature in many coating applications. The aim of this study is to achieve this through the introduction of an unmodified nanoclay, montmorillonite (Na(+)MMT), in a polymer resin based on the hyperbranched polyester Boltorn H30. Smooth and transparent films were prepared from both the neat and the nanoparticle-filled hyperbranched resins. X-ray diffraction (XRD) and transmission electron microscopy (TEM) corroborated a mainly exfoliated structure in the nanocomposite films, which was also supported by results from dynamic mechanical analysis (DMA). Furthermore, DMA measurements showed a 9-16 degrees C increase in Tg and a higher storage modulus-above and below the T(g)-both indications of a more cross-linked network, for the clay-containing film. Thermogravimetric analysis (TGA) demonstrated the influence of the nanofiller on the thermal properties of the nanocomposites, where a shift upward of the decomposition temperature in oxygen atmosphere is attributed to the improved barrier properties of the nanoparticle-filled materials. Conventional coating characterization methods demonstrated an increase in the surface hardness, scratch resistance and flexibility, with the introduction of clay, and all coatings exhibited excellent chemical resistance and adhesion.

  18. DETERMINING MONOFILAMENT GILLNET OPTIMUM MESH SIZE TO MITIGATE Amphilophus citrinellus POPULATION OUTBREAKS IN IR.H.DJUANDA RESERVOIR

    Directory of Open Access Journals (Sweden)

    Prawira A.R.P. Tampubolon

    2015-12-01

    Full Text Available Gillnet is the most common fishing gear used by fishers in Ir. H. Djuanda Reservoir. Currently, gillnet catches are dominated by midas cichlid (Amphilophus citrinellus which is not the main target catch. To some extent, their presence is even considered intrusive by the fishers. The aim of this study is to reveal the optimum gillnet mesh size in catching this alien species, which in turn can be useful to control the fish population in Ir. H. Djuanda Reservoir. The study was conducted from August 2011 to January 2012. The mesh size of the gillnets were 1, 1.5, 2, 2.5, 3, and 3.5 inches. The total midas cichlid caught were 628 fish which were mostly caught in 1.5 inches sized gillnet. Length first mature fish is 13.31 cm. The optimum size of fish caught in the mesh of 1.5, 2, 2.5, 3, and 3.5 inches are 9.7, 12.9, 16.2, 19.4, and 22.6 cm, respectively.

  19. Release of non-methane organic compounds during simulated landfilling of aerobically pretreated municipal solid waste.

    Science.gov (United States)

    Zhang, Yuanyuan; Yue, Dongbei; Liu, Jianguo; Lu, Peng; Wang, Ying; Liu, Jing; Nie, Yongfeng

    2012-06-30

    Characteristics of non-methane organic compounds (NMOCs) emissions during the anaerobic decomposition of untreated (APD-0) and four aerobically pretreated (APD-20, APD-39, APD-49, and APD-63) samples of municipal solid waste (MSW) were investigated in laboratory. The cumulative mass of the NMOCs of APD-20, APD-39, APD-49, and APD-63 accounted for 15%, 9%, 16%, and 15% of that of APD-0, respectively. The intensities of the NMOC emissions calculated by dividing the cumulative NMOC emissions by the quantities of organic matter removed (Q(VS)) decreased from 4.1 mg/kg Q(VS) for APD-0 to 0.8-3.4 mg/kg Q(VS) for aerobically pretreated MSW. The lipid and starch contents might have significant impact on the intensity of the NMOC emissions. Alkanes dominated the NMOCs released from the aerobically pretreated MSW, while oxygenated compounds were the chief component of the NMOCs generated from untreated MSW. Aerobic pretreatment of MSW prior to landfilling reduces the organic content of the waste and the intensity of the NMOC emissions, and increases the odor threshold, thereby reducing the environmental impact of landfills. Copyright © 2012 Elsevier Ltd. All rights reserved.

  20. Children are aware of food insecurity and take responsibility for managing food resources.

    Science.gov (United States)

    Fram, Maryah Stella; Frongillo, Edward A; Jones, Sonya J; Williams, Roger C; Burke, Michael P; DeLoach, Kendra P; Blake, Christine E

    2011-06-01

    Child food insecurity is measured using parental reports of children's experiences based on an adult-generated conceptualization. Research on other child experiences (e.g. pain, exposure to domestic violence) cautions that children generally best report their own experiences, and parents' reports of children's experiences may lack adequate validity and impede effective intervention. Because this may be true of child food insecurity, we conducted semistructured interviews with mothers, children (age 9-16 y), and other household adults in 26 South Carolina families at risk for food insecurity. Interview transcripts were analyzed using a constant comparative process combining a priori with inductive coding. Child interviews revealed experiences of food insecurity distinct from parent experiences and from parent reports of children's experiences. Children experienced cognitive, emotional, and physical awareness of food insecurity. Children took responsibility for managing food resources through participation in parental strategies, initiation of their own strategies, and generation of resources to provide food for the family. Adults were not always aware of children's experiences. Where adult experiences of food insecurity are conditioned on inadequate money for food, child experiences were grounded in the immediate household social and food environment: quality of child/parent interactions, parent affect and behavior, and types and quantities of foods made available for children to eat. The new, child-derived understanding of what children experience that results from this study provides a critical basis from which to build effective approaches to identify, assess, and respond to children suffering from food insecurity.

  1. Outcomes of Pulmonary Valve Replacement for Correction Pulmonary Insufficiency after Primary Repair of Tetralogy of Fallot (TOF

    Directory of Open Access Journals (Sweden)

    Mohammad Abbassi Teshnisi

    2016-09-01

    Full Text Available Background Total correction of Tetralogy of Fallot (TOF anomaly in early childhood has been practiced in many centers with good results, but in some of patients after few years sever Pulmonary valve insufficiency occurred. Materials and Methods At a cross- sectional study from January 2015 to January 2016, 10 patients who had history of primary repair of TOF with free pulmonary insufficiency (PI that underwent of pulmonary valve replacement (PVR with bioprosthetic valves were evaluated. Results Themean age of patients was 6.5 + 0.753 years old (ranged 8-12 years old and male to female ratio was 6/4. The mean of Intensive care unit (ICU stay and Hospital stay was 4.5+ 0.712 days (ranged 3-8 and 11.5+ 0.357 days (ranged 9- 16. Mean of cardiopulmonary bypass time and operation time was 45 + 0.684 min (ranged 32-60 and 83 + 0.317 min (ranged 65-112. In this study we did not find any mortality and ventricular arrhythmia and Heart block. There was only one case (10% with superficial wound infection that was controlled. At 6 months follow up, all of patients were alive, but Echocardiography sign of Right Ventricular (RV failure was present in 2 patients (20% recently. Conclusion Although for Pulmonary insufficiency after primary TOF repair there is controversial in studies, but we had good results of PVR with Bioprosthesis in TOF patients.

  2. Social and individual determinants of adolescents' acceptance of novel healthy and cool snack products.

    Science.gov (United States)

    Nørgaard, Maria Kümpel; Sørensen, Bjarne Taulo; Grunert, Klaus G

    2014-12-01

    Four new, healthy snack products, consisting of fruit, vegetables, bread, dip and topping, were tested with 600 Danish adolescents aged 9-16. Participants could view, handle, and test the products in a school setting. Acceptance was measured by overall buying intention, as well as buying intention contingent on specific substitutes and on the social situation. Price consciousness, health consciousness, snack neophobia, peer influence, social activities and word-of-mouth were measured as potential determinants of acceptance of the novel products. An exploratory analysis in TETRAD suggested that the measured constructs form three layers, with overall buying intention as the terminal causal effect, health consciousness, word of mouth, snack neophobia and peer influence as endogenous determinants, and social activities and the contingent buying intentions as mediators. Estimation of the causal relationships was conducted in LISREL. Findings show a predominance of social factors as determinants of novel snack acceptance, whereas health consciousness had only a weak and indirect effect on buying intentions and the effect of snack neophobia was partly mediated by social factors. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Novel method of determination of D9-tetrahydrocannabinol(THC) in human serum by high-performance liquid chromatography with electrochemical detection.

    Science.gov (United States)

    Kokubun, Hideya; Uezono, Yasuhito; Matoba, Motohiro

    2014-04-01

    In Europe and the United States, D9-tetrahydrocannabinol(THC, dronabinol), one of the psychoactive constituents of cannabis, has been used for both its anti-emetic and orexigenic effects in cancer patient receiving chemotherapy.However, dronabinol has not yet been launched in the market in Japan.In the future, it is necessary to ascertain the pharmacokinetics of dronabinol in cancer paitient.Therefore, we developed an HPLC procedure using electrochemical detection(ECD)for quan- titation of the concentrations of dronabinol in blood.An eluent of 50mM KH2PO4/CH3CN(9:16)was used as the mobile phase.The column was used the XTerra®RP18, and the voltage of the electrochemical detector in dronabinol was set at 400 mV.As a result, the calibration curve was linear in the range of 10 ng/mL to 100 ng/mL(y=964.85x -3,419, r=0.997).The lower limit of quantification was 0.5 ng/mL(S/N=3).The relative within-runs and between-runs standard deviations for the assay dronabinol were less than 4.7%. The method reported here is superior to previously reported methods in cancer patient.

  4. On the decay properties of sup 2 sup 6 sup 9 Hs and indications for the new nuclide sup 2 sup 7 sup 0 Hs

    CERN Document Server

    Türler, A; Gäggeler, H W; Kirbach, U W; Ginter, T N; Gregorich, K E; Lee, D M; Yakushev, A B; Schädel, M; Brüchle, W; Jäger, E; Dressler, R; Eichler, B; Eichler, R; Glaus, F; Jost, D T; Eberhardt, K; Hoffman, D C; Nitsche, H; Patin, J B; Pershina, V; Piguet, D; Qin, Z; Schausten, B; Schimpf, E; Schoett, H J; Soverna, S; Sudowe, R; Thörle, P; Timokhin, S N; Trautmann, N; Vahle, A; Wirth, G; Zielinski, P M

    2003-01-01

    In bombardments of sup 2 sup 4 sup 8 Cm with 143.7-146.8 MeV sup 2 sup 6 Mg ions the nuclides sup 2 sup 6 sup 9 Hs and presumably sup 2 sup 7 sup 0 Hs were produced. After chemical isolation, Hs atoms were identified by observing genetically linked nuclear-decay chains. Three chains originating from sup 2 sup 6 sup 9 Hs confirmed the decay properties observed previously in the decay of sup 2 sup 7 sup 7 112. Two chains exhibited the characteristics expected for the new nuclide sup 2 sup 7 sup 0 Hs, which was predicted to be a deformed ''doubly magic'' nucleus. From the measured E subalpha =9.16 sup + sup 0 sup . sup 0 sup 7 sub - sub 0 sub . sub 0 sub 3 MeV an alpha-decay half-life of 3.6 sup + sup 0 sup . sup 8 sub - sub 1 sub . sub 4 s was estimated. (orig.)

  5. The Behavioral Factor Associated with The Incidence of Malariain Endemic Area

    Directory of Open Access Journals (Sweden)

    Siti Thomas Zulaikhah

    2011-12-01

    Design and Methods: In this observasional study using case control design include 40 cases and 40 controls using the simple random sampling. Chi square test followed by double-logistic regression was applied for the data analysis with p=5%. Results: Bivariate analysis on the 6 factors resulted in p0.05. multivariate analysis showed that the habit factor of going out in the evening, installing wire gauze on the ventilation, hanging used clothes, mowing lawn, the existence of closed waste basket, washing the curtain resulted in the p=0.010 (OR = 10; 95% CI = 3.4-39.2, p=0.001 (OR = 4.1; 95% CI = 3.5-15.8, p=0.018 (OR = 3.3; 95% CI = 1.9 -16.2, p=0.044 (OR = 6.5; 95% CI = 2.1-30.9, p=0.380 (OR = 0.43; 95% CI = 0.1-1.2, p=0.002 (OR = 2.4; 95% CI =3.4 -5.6 respectively. Conclusion: The habit of going out in the evening has been shown to be most important behavioral factor associated with the malaria incidence (Sains Medika, 3(2:168-184.

  6. Microsatellite diversity of Kessler’s loach, Paraschistura kessleri (Nemacheilidae, Gunther, 1889 in Khorasan Razavi

    Directory of Open Access Journals (Sweden)

    Ali Shabani

    2016-09-01

    Full Text Available To study genetic structure of Paraschistura kessleri, a freshwater endemic species of Iran, 84 samples were collected from Kardeh, Zavin and Radkan rivers in Razavi Khorasan province and investigated with six microsatellite loci. Results indicated that Kessler's loach have proper allelic diversity (average: 9.16 and heterozygosity (average: 0.65 in studied regions. Only 4 of 18 loci-population tests were in Hardy-Weinberg equilibrium. The values of Fst and Rst as genetic differentiation indices were obtained 0.034 and 0.061, respectively. In this regard, the relatively high rate of gene flow, Nm: 7.28 could be considered as an important factor involved in low genetic differentiation obtained among the samples of investigated rivers. Also, the observed gene flow could be related to some factors including pollution, floods and life history of Kessler's loach. Results from analysis of molecular variance showed the majority of observed diversity is within populations. The highest genetic identity and distance values were observed among the samples of Radkan with Kardeh and Zavin with Radkan, respectively. Also, UPGMA dendrogram based on genetic distance showed that there are probably two separate populations of Kessler's loach in the investigated regions as Zavin was in a branch separate from Kardeh and Radkan.

  7. IMPORTANT NOTICE: Cancellation of shuttle Circuit 3

    CERN Multimedia

    2013-01-01

    Circuit 3 of the CERN Shuttle Service (Point 5), which has served CMS since the start of LS1, will be cancelled with effect from Tuesday 16 April. This decision has been taken in consultation with CMS, as the circuit was seldom used.   In response to increasing demand for Circuit 1 - Meyrin and feedback from passengers, the two Circuit 3 journeys will be switched to Circuit 1 – Meyrin (see new timetable below): Mornings: Four journeys instead of three. Circuit 1 now starts at 8:10 (instead of 8:19 a.m.) and runs until 9:27 a.m. (instead of 9:16 a.m.). Lunchtimes: Five journeys in place between 12:10 p.m. and 1:47 p.m. Evenings: Circuit starts at 5:23 p.m. (instead of 5:03 p.m.) and ends at 6:20 p.m. at Building 33. Please note that the circuit will depart from Building 13 instead of Building 33.  

  8. Effect of the New Plant Growth Biostimulants Based on Amino Acids on Yield and Grain Quality of Winter Wheat.

    Science.gov (United States)

    Popko, Małgorzata; Michalak, Izabela; Wilk, Radosław; Gramza, Mateusz; Chojnacka, Katarzyna; Górecki, Henryk

    2018-02-21

    Field and laboratory experiments were carried out in 2012-2013, aimed at evaluating the influence of new products stimulating plant growth based on amino acids on crop yield, characteristics of grain and content of macro- and micronutrients in winter wheat ( Triticum aestivum L.). The tests included two formulations produced in cooperation with INTERMAG Co. (Olkusz, Poland)-AminoPrim and AminoHort, containing 15% and 20% amino acids, respectively, and 0.27% and 2.1% microelements, respectively. Field experiments showed that the application of products based on amino acids influenced the increase of grain yield of winter wheat (5.4% and 11%, respectively, for the application of AminoPrim at a dose 1.0 L/ha and AminoHort at dose 1.25 L/ha) when compared to the control group without biostimulant. Laboratory tests showed an increase of technological characteristics of grain such as ash content, Zeleny sedimentation index and content of protein. The use of the tested preparations at different doses also contributed to the increase of the nutrients content in grains, in particular copper (ranging 31-50%), as well as sodium (35-43%), calcium (4.3-7.9%) and molybdenum (3.9-16%). Biostimulants based on amino acids, tested in the present study, can be recommended for an efficient agricultural production.

  9. Misuse of prescription stimulant medication in a sample of college students: examining differences between varsity athletes and non-athletes.

    Science.gov (United States)

    Gallucci, Andrew R; Martin, Ryan J

    2015-12-01

    The misuse of prescription stimulants (MPS) has been identified as an adverse health behavior among college students. Because stimulant medication is often taken to increase focus and decrease reaction time, these substances have the potential to enhance athletic performance. However, the role that athlete status (varsity athlete vs. non-athlete) has on MPS has rarely been examined in the college student population. To examine whether there are differences in past-year MPS and MPS-related motivations between college varsity athletes and non-athletes. A sample of 682 (482 non-athletes; 200 athletes) college students between the ages of 18 and 25 completed a paper-based questionnaire to assess MPS, MPS-related motivations, and other potential MPS correlates (e.g., gender, energy drink consumption, tobacco use, heavy episodic drinking). Then, we conducted bivariate and multivariate analyses to examine potential correlates of MPS, including athlete status. Finally, we examined differences in MPS-related motivations between varsity athletes and non-athletes. Overall, 98 (13.9%; 16.6% non-athletes v. 7.5% varsity athletes) respondents reported past-year MPS and varsity athletes were significantly less likely (pmotivations, athletes more often cited a need to enhance athletic performance as the impetus for their misuse. MPS was prevalent among the sample. Varsity athletes were significantly less likely to engage in past-year MPS and were motivated to do so for different reasons. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. Evaluation of the efficacy of afoxolaner against two European dog tick species: Dermacentor reticulatus and Ixodes ricinus.

    Science.gov (United States)

    Dumont, Pascal; Blair, Jeffrey; Fourie, Josephus J; Chester, Theodore S; Larsen, Diane L

    2014-04-02

    The acaricidal efficacy of a novel oral formulation of afoxolaner (NEXGARD(®), Merial) against two European tick species was assessed in dogs experimentally infested with Ixodes ricinus and Dermacentor reticulatus. Three studies, each characterized by a negative controlled randomized block design, were conducted with a total of 52 beagle or mongrel dogs of both sexes. Starting 2 days before treatment, each dog was infested weekly with approximately 50 ticks. The number of live ticks was counted at 48 h post-treatment (Day 2) as well as 48 h following each infestation on Days 9, 16, 23, and 30. Afoxolaner, administered at an average dose of 2.7 mg/kg bodyweight (range 2.5-2.9 mg/kg), rapidly eliminated the pre-existing tick infestations with over 99% acaricidal efficacy and controlled the weekly re-infestations for up to 30 days post treatment with over 96% efficacy on both tick species. Afoxolaner provides excellent acaricidal efficacy against these two major European tick species using the oral route of administration. Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

  11. Levels of depression and anxiety among parents of autistic children

    Directory of Open Access Journals (Sweden)

    Sunay Firat

    2016-09-01

    Results: Participants in the study were parents of 26 male (65% and 14 female (35% autistic children. The average age of the children was 62.9+/-16.6 months. .Mothers had higher levels of depression and anxiety scores. Mothers of autistic children who participated in the study received higher scores on depression, state anxiety and trait anxiety compared to fathers. Among mothers, a significant relationship was found between level of education and level of state anxiety. Conclusion: The findings of this study show that mothers have higher levels of depression and anxiety compared to fathers. This finding might be explained with reference to customs and traditions of the Turkish society in which the study was conducted, which require women to take more responsiblity for family matters. It is recommended that special education and rehabilitation centers provide counseling to parents about the effects of having an autistic children on their lives, and advise them on seeking psychological help if necessary. [Cukurova Med J 2016; 41(3.000: 539-547

  12. NO-NSAIDs. Part 3: nitric oxide-releasing prodrugs of non-steroidal anti-inflammatory drugs.

    Science.gov (United States)

    Borhade, Namdev; Pathan, Asif Rahimkhan; Halder, Somnath; Karwa, Manoj; Dhiman, Mini; Pamidiboina, Venu; Gund, Machhindra; Deshattiwar, Jagannath Janardhan; Mali, Sunil Vasantrao; Deshmukh, Nitin Janardanrao; Senthilkumar, Subrayan Palanisamy; Gaikwad, Parikshit; Tipparam, Santhosh Goud; Mudgal, Jayesh; Dutta, Milan Chandra; Burhan, Aslam Usmangani; Thakre, Gajanan; Sharma, Ankur; Deshpande, Shubhada; Desai, Dattatraya Chandrakant; Dubash, Nauzer Pervez; Jain, Arun Kumar; Sharma, Somesh; Nemmani, Kumar Venkata Subrahmanya; Satyam, Apparao

    2012-01-01

    In continuation of our efforts to discover novel nitric oxide-releasing non-steroidal anti-inflammatory drugs (NO-NSAIDs) as potentially "Safe NSAIDs," we report herein the design, synthesis and evaluation of 21 new NO-NSAIDs of commonly used NSAIDs such as aspirin, diclofenac, naproxen, flurbiprofen, ketoprofen, sulindac, ibuprofen and indomethacin. These prodrugs have NO-releasing disulfide linker attached to a parent NSAID via linkages such as an ester (compounds 9-16), a double ester (compounds 17-24), an imide (compounds 25-30) or an amide (compounds 31-33). Among these NO-NSAIDs, the ester-containing NO-aspirin (9), NO-diclofenac (10), NO-naproxen (11), and the imide-containing NO-aspirin (25), NO-flurbiprofen (27) and NO-ketoprofen (28) have shown promising oral absorption, anti-inflammatory activity and NO-releasing property, and also protected rats from NSAID-induced gastric damage. NO-aspirin compound 25, on further co-evaluation with aspirin at equimolar doses, exhibited comparable dose-dependent pharmacokinetics, inhibition of gastric mucosal prostaglandin E(2) (PGE(2)) synthesis and analgesic properties to those of aspirin, but retained its gastric-sparing properties even after doubling its oral dose. These promising NO-NSAIDs could therefore represent a new class of potentially "Safe NSAIDs" for the treatment of arthritic pain and inflammation.

  13. A study on total phenolics and vitamin c contents of kalecik karasi (vitis vinifera l.) clones

    International Nuclear Information System (INIS)

    Keskin, N.; Keskin, S.

    2014-01-01

    In this study total phenolic and vitamin C contents of the fully ripe berries of 23 clones of Kalecik Karasi which is one of the leading Turkish local red-wine grape cultivar originally grown in Kizilirmak valley near Kalecik/Ankara region were examined under the clone selection project supported by TUBTAK (Project Nr: 107 O 731). High-pressure liquid chromatography (HPLC) was used for vitamin C and spectrophotometer for total phenolics estimation. One way ANOVA was used to compare means of clone for their total phenolic and vitamin C contents. In addition to this univariate method, hierarchical cluster analysis was performed to identify similarity levels among the clones by considering total phenolics and vitamin C content together. Differences among the clones were found statistically significant for both characteristics. Total phenolic contents of the clones varied from 3.310 mg (clone 21) to 3.389 mg (clone 6) as GAE g fw. Vitamin C content ranged from 14.010 mg (clone 6) to 16.500 mg (clone 19) in 100g fw. Furthermore, similarity level for all clones was 83.1% that means variation rate is about 17% among the clones. As a summary of whole data, the first three performing clones are 6 (3.389 mg), 10 (3.374 mg) and 1 (3.365 mg) for total phenolics, and 19 (16.500 mg), 9 (16.020 mg), and 21 (16.015 mg) for vitamin C contents of the berries. (author)

  14. Factors associated with mother-to-child transmission of the human immunodeficiency virus in Pernambuco, Brazil, 2000-2009.

    Science.gov (United States)

    da Cruz Gouveia, Pedro Alves; da Silva, Gerlane Alves Pontes; de Fatima Pessoa Militão de Albuquerque, Maria

    2013-03-01

    To identify risk factors associated with mother-to-child transmission of HIV in the Brazilian state of Pernambuco. Retrospective cohort study with 1200 HIV-exposed children born in Pernambuco, registered up to the age of 2 months in a public programme to prevent vertical transmission. Univariate and multivariate logistic regression analyses were conducted for maternal and peripartum characteristics and prophylactic interventions, to identify risk factors for mother-to-child transmission of HIV. The transmission rate was 9.16% (95% CI: 7.4-10.9). The following risk factors were independently associated with transmission: non-use of antiretroviral during pregnancy (OR: 7.8; 95% CI: 4.1-15); vaginal delivery (OR: 2.02; 95% CI: 1.2-3.4); prematurity (OR: 2.5; 95% CI: 1.3-4.7); and breastfeeding (OR: 2.6; 95% CI: 1.4-4.6). This mother-to-child transmission rate is unacceptably high, as prophylactic interventions such as antiretroviral therapy and infant feeding formula are free of charge. Absence of antiretroviral therapy during pregnancy was the main risk factor. Therefore, early identification of exposed mothers and initiating prophylactic interventions are the main challenges for controlling transmission. © 2012 Blackwell Publishing Ltd.

  15. In-vitro fermentation characteristics and methane reduction potential of mustard cake (Brassica juncea L.)

    Science.gov (United States)

    Durge, S. M.; Tripathi, M. K.; Dutta, N.

    2016-01-01

    Aim: To assess the effect of mustard cake (Brassica juncea L.) levels in concentrate mixtures and in composite feed mixtures (CFMs) on in-vitro fermentation characteristics and methane production. Materials and Methods: Five concentrate mixtures were prepared with containing 30% oil cake, where linseed cake was replaced by mustard cake at the rate of 0%, 7.5%, 15.0%, 22.5%, and 30% in concentrate mixture. Mustard cake contained glucosinolate 72.58 µmol/g oil free dry matter (DM) and contents in diet were 0, 5.4, 10.9, 16.3, and 21.8 µmol/g of concentrate mixture, respectively. Concentrate mixture containing 15.0% mustard cake was found to produced minimum methane which was then used for the preparation of CFM containing 0%, 25%, 50%, and 75% levels with gram straw. Result: Increased levels of mustard cake in concentrate mixtures had a linear decrease (pgas production, and the 15% inclusion showed lowest methane concentration (quadratic, pmustard cake levels. Increased levels of 15% mustard cake containing concentrate mixture in CFMs exhibited a trend (p=0.052) of increased gas production, whereas methane concentration in total gas, methane produced and degradability of DM and OM were also displayed a linear increase (pmustard cake in concentrate mixture at 15% level, and the CFMs with 25% concentrate, which contained 15% mustard cake, exhibited an improved fermentation and reduced methane production. PMID:27847426

  16. HIV and other predictors of serum folate, serum ferritin, and hemoglobin in pregnancy

    DEFF Research Database (Denmark)

    Friis, Henrik; Gomo, E; Kæstel, Pernille

    2001-01-01

    ) in Harare, Zimbabwe, who were receiving prenatal care. The statistical effects of age, season, gestational age, gravidity, HIV-1 infection, malaria parasitemia, and serum alpha1-antichymotrypsin (ACT) on serum folate, serum ferritin (log10 transformed), and hemoglobin were estimated by using multiple linear...... regression analyses. RESULTS: Serum folate (x: 11.4 micromol/L) was 0.52-nmol/L (95% CI: 0.04, 1.0) lower in HIV-infected women than in uninfected women and 0.65-nmol/L (0.014, 1.28) lower in weeks 25-35 than in weeks 22-25. Serum ferritin (geometric x: 11.6 microg/L) was 0.93 times (0.86, 0.99) lower in HIV...... predictor of serum folate, serum ferritin, and hemoglobin. HIV infection was associated with a 12.9-g/L (8.9, 16.8) lower hemoglobin concentration in women with nondepleted iron stores but low serum retinol and a 7-8-g/L lower hemoglobin concentration in women with other combinations of serum ferritin...

  17. Decreased gastrocnemius temporal muscle activation during gait in elderly women with history of recurrent falls.

    Science.gov (United States)

    Kirkwood, Renata Noce; Trede, Renato Guilherme; Moreira, Bruno de Souza; Kirkwood, Scott Alexander; Pereira, Leani Souza Máximo

    2011-05-01

    Gait dysfunction is a strong issue in elderly women with a history of falls. The purpose of this study was to compare the temporal activity of the ankle muscles during gait in elderly women with and without a history of recurrent falls. Eighty-nine (89) elderly women - one group with a history of falls (45) and another group without (44) - participated in the study. The mean range of temporal activation of the gastrocnemius, tibialis anterior and soleus muscles during gait was obtained using electromyography. The muscles were considered active when the signal magnitude surpassed two standard deviations of the minimal magnitude of the average signal per individual. The results showed that the mean range of gastrocnemius muscle activation of the group of recurrent fallers was significantly shorter, 2.9% (16.9±5.7%) compared to the group without recurrent falls (19.8±6.6%) (p=0.004). The shorter duration in the gastrocnemius muscle activation during stance could possibly affect stability in the support phase, since the gastrocnemius is the main decelerator of the trunk. Clinically, this finding shows the importance of rehabilitation programs for elderly women that focus on strengthening the plantar flexor musculature aiming to reestablish the function and stability of gait and possibly avoiding falls. Copyright © 2011 Elsevier B.V. All rights reserved.

  18. Treatment of HBV and HDV co-infection using lamivudine

    International Nuclear Information System (INIS)

    Qureshi, H.; Arif, A.; Alam, E.

    2009-01-01

    To see effect of Lamivudine on sero conversion of HBeAg positive cases co infected with Delta hepatitis. Hepatitis B positive patients with deranged liver functions for 6 months were tested for HBeAg, HBV DNA and anti-Delta virus (HDV), using ELISA. Patients were divided into 2 groups, group 1: HBeAg, HBV DNA positive (wild type) but delta negative and group 2: HBeAg, HBV DNA positive (wild type) with delta positive. Lamivudine (100 mg) was advised to both groups till sero-conversion. Of 124 cases in year 1999-2005, 69 were in (Group 1), and 55 were in (Group 2). Eighty percent were males in both groups. ALT normalisation occurred in 75%, 24% cases within 6 months respectively. At the start of therapy mean HBeAg was 289+-189 in group 1 and 142+-160 in group 2. With treatment, the values did not change much till 12 months of therapy. The fall was significantly slow in delta positive cases. At 36 months 26 (38%) cases in group 1 and 9 (16.4%) cases in group 2 sero-converted. Nine cases in each group remained non-responders while 2 in each group relapsed. Wild type of HBV/HDV co-infected cases have a 16% chance of seroconversion which negates the concept that once infected with delta virus there is not much that can be done. (author)

  19. Reliability of thickness of oxide layer of stainless steels with chromium using cellular automaton model

    International Nuclear Information System (INIS)

    Lan, K. C.; Chen, Y.; Yu, G. P.; Hung, T. C.

    2012-01-01

    A cellular automaton (CA) model based on the stochastic approach was proposed to simulate the process of oxidation and corrosion of stainless steels with different contents of chromium in-flowing lead bismuth eutectic (LBE). Chromium is a crucial alloying element added in stainless steels and nickel based alloys which have been proposed to be used in advanced nuclear reactors to improve resistance of the oxidation and corrosion. To verify the reliability of the thickness of the oxide layer by CA model, the influence of the stochastic character on the simulating results was investigated as changing parameter of chromium content of structure material in this study. Ten independent simulations were run for each specific environment. A stable and reasonable results were obtained according to the chi-square of goodness-of-fit test, the chi-square of the thickness of oxide layer for each case were significant smaller than critical chi-square value with a confidence level of 95% (Χ 2 α, v = Χ 2 0.05,9 = 16.92). (authors)

  20. Reclassification of Lactobacillus kimchii and Lactobacillus bobalius as later subjective synonyms of Lactobacillus paralimentarius.

    Science.gov (United States)

    Pang, Huili; Kitahara, Maki; Tan, Zhongfang; Wang, Yanping; Qin, Guangyong; Ohkuma, Moriya; Cai, Yimin

    2012-10-01

    Characterization and identification of strain CW 1 ( = JCM 17161) isolated from corn silage were performed. Strain CW 1 was a Gram-positive, catalase-negative and homofermentative rod that produced the DL-form of lactic acid. This strain exhibited more than 99.6% 16S rRNA gene sequence similarity and greater than 82% DNA-DNA reassociation with type strains of Lactobacillus kimchii, L. bobalius and L. paralimentarius. To clarify the taxonomic positions of these type strains, phenotypic characterization, 16S rRNA gene sequencing, ribotyping and DNA-DNA relatedness were examined. The three type strains displayed different L-arabinose, lactose, melibiose, melezitose, raffinose and N-acetyl-β-glucosaminidase fermentation patterns. Phylogenetic analysis showed that L. paralimentarius is a closer neighbour of L. kimchii and L. bobalius, sharing 99.5-99.9% 16S rRNA gene sequence similarity, which was confirmed by the high DNA-DNA relatedness (≥82%) between L. paralimentarius JCM 10415(T), L. bobalius JCM 16180(T) and L. kimchii JCM 10707(T). Therefore, it is proposed that L. kimchii and L. bobalius should be reclassified as later synonyms of L. paralimentarius.

  1. Evaluation of Stages and Mean Age of Onset of Puberty in Boys of Yazd

    Directory of Open Access Journals (Sweden)

    M Golestan

    2009-07-01

    Full Text Available Introduction: Genetic and health factors along with ethnicity and geographic location are factors that affect the time of puberty onset. The aim of the present study was to evaluate the mean age of onset of puberty and its stages in boys of Yazd. Methods: This cross- sectional study with random clustering sampling method was conducted on 1018 healthy 9-16 years old male students of Yazd. All cases were examined and evaluated for onset and secondary characters of puberty with inspection of the genital region for pubic hair and scrotum and testicular size according to Tanner classification. Results: The mean age of G2 (onset of testicular growth and PH2 (onset of pubic hairs growth was 11.57±1.54 and 12.43±1.07 years. The mean age of G5 (final stage of testicular growth and PH5 (final stage of pubic hairs growth was 15.43±0.8 and 15.69±1.1 years. The mean BMI in the early stages of puberty (G2 was 16.32±2.02. Conclusion: The mean age of onset of puberty (G2 in boys of Yazd was 11.5 years that is similar to other researches in other countries.

  2. Comparison of the effects of model-based iterative reconstruction and filtered back projection algorithms on software measurements in pulmonary subsolid nodules

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, Julien G. [Seoul National University College of Medicine, Department of Radiology, Seoul (Korea, Republic of); Seoul National University Medical Research Center, Institute of Radiation Medicine, Seoul (Korea, Republic of); Centre Hospitalier Universitaire de Grenoble, Clinique Universitaire de Radiologie et Imagerie Medicale (CURIM), Universite Grenoble Alpes, Grenoble Cedex 9 (France); Kim, Hyungjin; Park, Su Bin [Seoul National University College of Medicine, Department of Radiology, Seoul (Korea, Republic of); Seoul National University Medical Research Center, Institute of Radiation Medicine, Seoul (Korea, Republic of); Ginneken, Bram van [Radboud University Nijmegen Medical Center, Department of Radiology and Nuclear Medicine, Nijmegen (Netherlands); Ferretti, Gilbert R. [Centre Hospitalier Universitaire de Grenoble, Clinique Universitaire de Radiologie et Imagerie Medicale (CURIM), Universite Grenoble Alpes, Grenoble Cedex 9 (France); Institut A Bonniot, INSERM U 823, La Tronche (France); Lee, Chang Hyun [Seoul National University College of Medicine, Department of Radiology, Seoul (Korea, Republic of); Goo, Jin Mo; Park, Chang Min [Seoul National University College of Medicine, Department of Radiology, Seoul (Korea, Republic of); Seoul National University Medical Research Center, Institute of Radiation Medicine, Seoul (Korea, Republic of); Seoul National University College of Medicine, Cancer Research Institute, Seoul (Korea, Republic of)

    2017-08-15

    To evaluate the differences between filtered back projection (FBP) and model-based iterative reconstruction (MBIR) algorithms on semi-automatic measurements in subsolid nodules (SSNs). Unenhanced CT scans of 73 SSNs obtained using the same protocol and reconstructed with both FBP and MBIR algorithms were evaluated by two radiologists. Diameter, mean attenuation, mass and volume of whole nodules and their solid components were measured. Intra- and interobserver variability and differences between FBP and MBIR were then evaluated using Bland-Altman method and Wilcoxon tests. Longest diameter, volume and mass of nodules and those of their solid components were significantly higher using MBIR (p < 0.05) with mean differences of 1.1% (limits of agreement, -6.4 to 8.5%), 3.2% (-20.9 to 27.3%) and 2.9% (-16.9 to 22.7%) and 3.2% (-20.5 to 27%), 6.3% (-51.9 to 64.6%), 6.6% (-50.1 to 63.3%), respectively. The limits of agreement between FBP and MBIR were within the range of intra- and interobserver variability for both algorithms with respect to the diameter, volume and mass of nodules and their solid components. There were no significant differences in intra- or interobserver variability between FBP and MBIR (p > 0.05). Semi-automatic measurements of SSNs significantly differed between FBP and MBIR; however, the differences were within the range of measurement variability. (orig.)

  3. Personal characteristics and contextual factors that determine "helping," "joining in," and "doing nothing" when witnessing cyberbullying.

    Science.gov (United States)

    Van Cleemput, Katrien; Vandebosch, Heidi; Pabian, Sara

    2014-01-01

    In this article, we investigated several determinants of bystanders' reactive behaviors when confronted with cyberbullying using self-reported data from 2,333 Flemish 9-16 year olds. Structural equation modeling showed that adolescents that had joined in on the cyberbullying were older, had lower levels of empathy and were more likely to have been involved in cyberbullying or traditional bullying as perpetrators. Adolescents who had helped the victim were younger, had higher levels of empathy and were more likely to have been a victim of cyberbullying or traditional bullying in the past months. Adolescents that did nothing when they witnessed cyberbullying, were also older, showed lower levels of empathy and were less likely to have been a victim of traditional bullying. Social anxiety was not related to joining in, helping and remaining passive. In the second part of the analysis, we found that bystanders' passive behavior could be explained in more detail by moral disengagement theory and other contextual factors. In the discussion, the implications of the findings for research on cyberbullying are addressed. © 2014 Wiley Periodicals, Inc.

  4. Muertes por homicidio, consecuencia fatal de la violencia: el caso de Mexico, 1979-1992

    Directory of Open Access Journals (Sweden)

    López María Victoria

    1996-01-01

    Full Text Available Se analizaron las muertes registradas como homicidio en México de 1979-1992. El estudio se basó en fuente secundaria, siendo las variables analizadas: año, edad, sexo y causa externa de traumatismos y envenenamientos según CIE IX Rev.(E960-E969. Se utilizó un modelo de regresión Poisson para las causas más frecuentes, obteniendo riesgos relativos según edad y sexo. El grupo de referencia fue el de 10-14 años y el sexo femenino. Se registraron 198,485 muertes por Homicidio, con un promedio anual de 14,177 y diario de 39. La principal causa fue ataque con arma de fuego y explosivos(56%. El riesgo relativo más alto fue para el grupo de 35-39 años, con RR 15,4 IC(95% 14,9-16,0, en comparación al de referencia. El sexo masculino presentó un riesgo relativo 10,1 veces mayor que el femenino, ajustado por edad IC10.0-10.3. Los resultados llaman la atención sobre la necesidad de profundizar y analizar el problema de los homicidios bajo una perspectiva multidisciplinaria.

  5. Changes in the avian cochlea after single high-dose gentamicin.

    Science.gov (United States)

    Girod, D A; Park, R H; Park, D L; Durham, D

    2000-01-01

    Define the time course of functional and anatomical damage and subsequent recovery (by regeneration) of hair cells in the chicken inner ear after a single high-dose of gentamicin. Broiler chicks were given a single intraperitoneal dose (200 mg/kg) of gentamicin (n = 39) or saline (n = 39). Functional status was evaluated with auditory brainstem response (ABR) thresholds before injection and before sacrifice at 2, 5, 9, 16, 21, 28, and 70 days postinjection. The cochleae were then examined with scanning electron microscopy (SEM) to assess the extent of damage along the cochlea and absolute hair cell numbers in the basal 15% of the cochlea (high-frequency region). Considerable variability between animals was seen for both ABR and SEM changes. Damage was maximal at 5 days postinjection with an average ABR threshold shift of 12 dB (range -10 to 50 dB) and basal cochlear damage of 28% (range 12%-57%). Hair cell counts were significantly decreased in the basal 15% of the cochlea at 5 days. Hair cell regeneration resulted in rapid anatomical and functional recovery, but evidence of hair cell disorganization persisted at 70 days despite improved thresholds. A single high dose of gentamicin produces a significant but variable anatomical and functional insult in the chick cochlea. Hair cell regeneration results in rapid but incomplete recovery.

  6. Preoperative combination of progressive pneumoperitoneum and botulinum toxin type A in patients with loss of domain hernia.

    Science.gov (United States)

    Bueno-Lledó, José; Torregrosa, Antonio; Jiménez, Raquel; Pastor, Providencia García

    2018-02-15

    Preoperative progressive pneumoperitoneum (PPP) and botulinum toxin type A (BT) are tools in the surgical preparation of patients with loss of domain hernias (LODH). The aim of this paper is to report our experience with these preoperative techniques in 70 patients with LODH. Observational study of 70 consecutive patients with LODH was conducted between May 2010 and May 2016. Diameters of the hernia sac, incisional hernia (VIH), and abdominal cavity (VAC) volumes, and VIH/VAC ratio were measured before and after PPP and BT, using abdominal CT scan data. Combination of both techniques was performed when the VIH/VAC ratio was > 20%. Median insufflated volume of air for PPP was 8450 ± 3400 cc (4500-13,450), over a period of 11.3 ± 2.3 days (9-16). BT administration time was 38.1 ± 3.7 days (35-44). An average reduction of 16.6% of the VIH/VAC ratio after PPP and BT was obtained (p VIH/VAC ratio and hernia defect diameters, which constitutes a key factor in the treatment of LODH.

  7. Conversion of Biomass-Derived Furans into Hydrocarbon Fuels

    Energy Technology Data Exchange (ETDEWEB)

    Moens, L.; Johnson, D. K.

    2013-01-01

    One of the most studied chemical transformations of carbohydrates is their thermocatalytic dehydration to form furans. Cellulose-derived glucose is thereby converted into 5-hydroxymethylfurfuraldehyde (5-HMF), while the hemicellulose-derived pentoses (e.g., xylose, arabinose) form furfuraldehyde. Our objective is to identify new pathways to convert furfuryl alcohol into a mixture of aliphatic hydrocarbons that can be used as drop-in fuels for diesel (C10-20) and jet fuel (C9-16) blends. Furfuryl alcohol is produced commercially through hydrogenation of furfuraldehyde that is derived from hemicellulose-derived pentoses via acid-catalyzed dehydration. The steps that we are currently pursuing to convert furfuryl alcohol into hydrocarbons are 1) oligomerization of furfuryl alcohol to form dimers (C10) and trimers (C15), and 2) hydrotreatment of the dimers and trimers to produce a mixture of linear hydrocarbons with carbon chain lengths in the range of diesel and jet fuels. This presentation will discuss our progress in the development of this pathway.

  8. Conversion of Pentose-Derived Furans into Hydrocarbon Fuels

    Energy Technology Data Exchange (ETDEWEB)

    Moens, L.; Johnson, D. K.

    2012-01-01

    We are interested in the conversion of biomass-derived hemicellulose into hydrocarbon molecules that can be used in the formulation of 'drop-in' fuels such as gasoline (C5-12), diesel (C10-20) and jet fuel (C9-16). Our focus lies on the use of furfuryl alcohol as a starting material since that is already produced commercially from hemicellulose-derived pentoses. The steps required to convert the latter into hydrocarbons are 1) oligomerization of furfuryl alcohol to form dimers (C10) and trimers (C15), and 2) hydrotreatment of the dimers and trimers to produce a mixture of linear hydrocarbons with carbon chain lengths in the range of diesel and jet fuels. However, furfuryl alcohol readily polymerizes to form resins in the presence of an acid catalyst, and the exothermic oligomerization must be carried out under reaction control. This presentation will discuss our progress in the development of this sugar-to-hydrocarbon pathway.

  9. Social network sensors for early detection of contagious outbreaks.

    Science.gov (United States)

    Christakis, Nicholas A; Fowler, James H

    2010-09-15

    Current methods for the detection of contagious outbreaks give contemporaneous information about the course of an epidemic at best. It is known that individuals near the center of a social network are likely to be infected sooner during the course of an outbreak, on average, than those at the periphery. Unfortunately, mapping a whole network to identify central individuals who might be monitored for infection is typically very difficult. We propose an alternative strategy that does not require ascertainment of global network structure, namely, simply monitoring the friends of randomly selected individuals. Such individuals are known to be more central. To evaluate whether such a friend group could indeed provide early detection, we studied a flu outbreak at Harvard College in late 2009. We followed 744 students who were either members of a group of randomly chosen individuals or a group of their friends. Based on clinical diagnoses, the progression of the epidemic in the friend group occurred 13.9 days (95% C.I. 9.9-16.6) in advance of the randomly chosen group (i.e., the population as a whole). The friend group also showed a significant lead time (psensor method could provide significant additional time to react to epidemics in small or large populations under surveillance. The amount of lead time will depend on features of the outbreak and the network at hand. The method could in principle be generalized to other biological, psychological, informational, or behavioral contagions that spread in networks.

  10. VOPcPhO:P3HT composite micro-structures with nano-porous surface morphology

    Energy Technology Data Exchange (ETDEWEB)

    Azmer, Mohamad Izzat [Low Dimensional Materials Research Centre (LDMRC), Department of Physics, Faculty of Science, University of Malaya, 50603 Kuala Lumpur (Malaysia); Ahmad, Zubair, E-mail: zubairtarar@qu.edu.qa [Center for Advanced Materials (CAM), Qatar University, P. O. Box 2713, Doha (Qatar); Sulaiman, Khaulah, E-mail: khaulah@um.edu.my [Low Dimensional Materials Research Centre (LDMRC), Department of Physics, Faculty of Science, University of Malaya, 50603 Kuala Lumpur (Malaysia); Touati, Farid [Department of Electrical Engineering, College of Engineering, Qatar University, P. O. Box 2713, Doha (Qatar); Bawazeer, Tahani M. [Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah (Saudi Arabia); Alsoufi, Mohammad S. [Mechanical Engineering Department, College of Engineering and Islamic Architecture, Umm Al-Qura University, Makkah (Saudi Arabia)

    2017-03-31

    Highlights: • VOPcPhO:P3HT micro-structures with nano-porous surface morphology have been formed. • Multidimensional structures have been formed by electro-spraying technique. • The electro-sprayed films are very promising for the humidity sensors. - Abstract: In this paper, composite micro-structures of Vanadyl 2,9,16,23-tetraphenoxy-29H,31H-phthalocyanine) (VOPcPhO) and Poly (3-hexylthiophene-2,5-diyl) (P3HT) complex with nano-porous surface morphology have been developed by electro-spraying technique. The structural and morphological characteristics of the VOPcPhO:P3HT composite films have been studied by field emission scanning electron microscopy (FESEM) and atomic force microscopy (AFM). The multidimensional VOPcPhO:P3HT micro-structures formed by electro-spraying with nano-porous surface morphology are very promising for the humidity sensors due to the pore sizes in the range of micro to nano-meters scale. The performance of the VOPcPhO:P3HT electro-sprayed sensor is superior in term of sensitivity, hysteresis and response/recovery times as compared to the spin-coated one. The electro-sprayed humidity sensor exhibits ∼3 times and 0.19 times lower hysteresis in capacitive and resistive mode, respectively, as compared to the spin-coated humidity sensor.

  11. Effects of oral contraceptives on the prevalence of alveolar osteitis after mandibular third molar surgery: a retrospective study.

    Science.gov (United States)

    Almeida, L E; Pierce, S; Klar, K; Sherman, K

    2016-10-01

    The objective of this study was to investigate the influence of oral contraceptives on the incidence rate of alveolar osteitis (AO) following the surgical extraction of both impacted mandibular third molars. This retrospective study reviewed the clinical records of patients who presented to the oral surgery clinic of a university school of dentistry for the extraction of impacted mandibular third molars. Using a database search, all patients were categorized by sex, age, occurrence of AO, and whether the females were taking oral contraceptives at the time of surgery. The patient was considered positive for AO if either one or both sockets developed AO. The incidence of AO among women taking oral contraceptives at the time of impacted mandibular third molar extraction differed significantly from that in the other patient groups. AO occurred in 37.9% (11/29) of females taking oral contraceptives, while only 8.9% (16/179) of females who were not taking oral contraceptives at the time of extraction developed AO. The total incidence of AO among females was 13.0% (27/208). The total incidence of AO among the 363 males and females presenting for mandibular third molar extractions was 13.8%. Females who are taking oral contraceptives at the time of impacted mandibular third molar extraction are at a higher risk of developing AO following extraction. Copyright © 2016 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

  12. First report of Cryptosporidium canis in farmed Arctic foxes (Vulpes lagopus) in China.

    Science.gov (United States)

    Zhang, Xiao-Xuan; Cong, Wei; Ma, Jian-Gang; Lou, Zhi-Long; Zheng, Wen-Bin; Zhao, Quan; Zhu, Xing-Quan

    2016-03-03

    Cryptosporidium is an important genus of enteric zoonotic parasites, which can infect a wide range of animals including foxes. Little information is available concerning the prevalence and molecular characterisation of Cryptosporidium spp. in farmed Arctic foxes (Vulpes lagopus) in China. Thus, the objective of the present study was to investigate the prevalence of Cryptosporidium spp. in Arctic foxes in China using nested PCR amplification of the small subunit ribosomal RNA (SSU rRNA) gene. The overall prevalence of Cryptosporidium spp. in Arctic foxes was 15.9 % (48/302), with 12.9 % in male (18/139) and 18.4 % in female (30/163) foxes, respectively. The prevalence in different farms varied from 0 to 31.43 %. The prevalence of infection in different age groups varied from 14.1 % to 19.0 %. Foxes from Hebei Province (7.8 %, 11/141) had a significantly lower Cryptosporidium spp. prevalence than those from Heilongjiang Province (22.9 %, 16/70) and Jilin Province (23.1 %, 21/91) (P= 0.0015). Sequence analysis of the SSU rRNA gene indicated that all the 48 isolates represented C. canis. This is the first report of C. canis infection in farmed Arctic foxes in China, which also provides foundation data for preventing and controlling Cryptosporidium infection in foxes, other animals and humans.

  13. Direct observation of the evolution of a seafloor 'black smoker' from vapor to brine

    Science.gov (United States)

    Von Damm, Karen L.; Buttermore, L.G.; Oosting, S.E.; Bray, A.M.; Fornari, D.J.; Lilley, M.D.; Shanks, Wayne C.

    1997-01-01

    A single hydrothermal vent, 'F' vent, occurring on very young crust at 9??16.8???N, East Pacific Rise, was sampled in 1991 and 1994. In 1991, at the measured temperature of 388??C and seafloor pressure of 258 bar, the fluids from this vent were on the two-phase curve for seawater. These fluids were very low in chlorinity and other dissolved species, and high in gases compared to seawater and most sampled seafloor hydrothermal vent fluids. In 1994, when this vent was next sampled, it had cooled to 351??C and was venting fluids ???1.5 times seawater chlorinity. This is the first reported example of a single seafloor hydrothermal vent evolving from vapor to brine. The 1991 and 1994 fluids sampled from this vent are compositionally conjugate pairs to one another. These results support the hypothesis that vapor-phase fluids vent in the early period following a volcanic eruption, and that the liquid-phase brines are stored within the oceanic crust, and vent at a later time, in this case 3 years. These results demonstrate that the venting of brines can occur in the same location, in fact from the same sulfide edifice, where the vapor-phase fluids vented previously.

  14. Novel Bartonella Species in Insectivorous Bats, Northern China.

    Directory of Open Access Journals (Sweden)

    Hui-Ju Han

    Full Text Available Bartonella species are emerging human pathogens. Bats are known to carry diverse Bartonella species, some of which are capable of infecting humans. However, as the second largest mammalian group by a number of species, the role of bats as the reservoirs of Bartonella species is not fully explored, in term of their species diversity and worldwide distribution. China, especially Northern China, harbors a number of endemic insectivorous bat species; however, to our knowledge, there are not yet studies about Bartonella in bats in China. The aim of the study was to investigate the prevalence and genetic diversity of Bartonella species in bats in Northern China. Bartonella species were detected by PCR amplification of gltA gene in 25.2% (27/107 bats in Mengyin County, Shandong Province of China, including 1/3 Rhinolophus ferrumequinum, 2/10 Rhinolophus pusillus, 9/16 Myotis fimbriatus, 1/5 Myotis ricketti, 14/58 Myotis pequinius. Phylogenetic analysis showed that Bartonella species detected in bats in this study clustered into ten groups, and some might be novel Bartonella species. An association between Bartonella species and bat species was demonstrated and co-infection with different Bartonella species in a single bat was also observed. Our findings expanded our knowledge on the genetic diversity of Bartonella in bats, and shed light on the ecology of bat-borne Bartonella species.

  15. Radioimmunoassay of plasma 18-hydroxy-11-deoxycorticosterone and its response to ACTH

    International Nuclear Information System (INIS)

    May, C.N.; Lewis, P.S.; Horth, C.E.

    1979-01-01

    A radioimmunoassay for 18-OH-DOC in plasma was developed using an antiserum raised against the γ-lactone derivative. The steroids with the greatest degree of cross reaction were 18-OH-corticosterone-γ-lactone and aldosterone-γ-lactone which showed cross-reactivities of 1.96% and 0.47% respectively. These and other interfering steroids were eliminated by chromatography of the extracts on columns of Sephadex LH-20. The lowest limit of detection of 18-OH-DOC in 1 ml of plasma corresponded to 33 pmol -1 . The intra-assay precision was 9.7, 4.8 and 2.6% at 102.0, 316.1 and 1144.0 pmol l -1 respectively and the interassay precision was 15.3 and 5.4% at 71.3 and 404.7 pmol l -1 respectively. The concentration of 18-OH-DOC in ten normal subjects was 172.1 +- 39.1 pmol l -1 at 09.00 h, 100.9 +- 16.9 pmol l -1 at 12.00 h and 95.8 +-33.3 pmol l -1 at 16.30 h. Plasma 18-OH-DOC and cortisol levels were measured after various intravenous doses of ACTH in three patients with essential hypertension. Lower doses of ACTH caused considerably greater increases in 18-OH-DOC. These results confirm the ACTH dependency of 18-OH-DOC secretion. (author)

  16. Development of delineation for the left anterior descending coronary artery region in left breast cancer radiotherapy: An optimized organ at risk.

    Science.gov (United States)

    Lee, Jie; Hua, Kai-Lung; Hsu, Shih-Ming; Lin, Jhen-Bin; Lee, Chou-Hsien; Lu, Kuo-Wei; Dai, Kun-Yao; Huang, Xu-Nian; Huang, Jun-Zhao; Wu, Meng-Hao; Chen, Yu-Jen

    2017-03-01

    The left anterior descending coronary artery (LAD) and diagonal branches (DBs) are blurred on computed tomography (CT). We aimed to define the LAD region (LADR) with adequate inclusion of the LAD and DBs and contouring consistency. The LADR was defined using coronary CT angiograms. The inclusion ratio was used to assess the LAD and DBs inclusion by the LADR. Four radiation oncologists delineated the LAD and LADR, using contrast-enhanced CT of 15 patients undergoing left breast radiotherapy. The Sørensen-Dice similarity index (DSI), Jaccard similarity index (JSI), and Hausdorff distance (HD) were calculated to assess similarity. The mean dose (D mean ) and maximum dose (D max ) to the LAD and LADR were calculated to compare consistency. Correlations were evaluated using Pearson's correlation coefficient. The inclusion ratio of the LAD by the LADR was 96%. The mean DSI, JSI, and HD values were respectively 27.9%, 16.7%, and 0.42mm for the LAD, and 83.1%, 73.0%, and 0.18mm for the LADR. The D mean between the LAD and LADR were strongly correlated (r=0.93). Delineation of the LADR significantly improved contouring similarity and consistency for dose reporting. This could optimize dose estimation for breast radiotherapy. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

  17. High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing's disease

    Energy Technology Data Exchange (ETDEWEB)

    Rotte, Alexandra A.J. de; Groenewegen, Amy; Rutgers, Dik R.; Witkamp, Theo; Luijten, Peter R.; Hendrikse, Jeroen [University Medical Center Utrecht, Department of Radiology, Utrecht (Netherlands); Zelissen, Pierre M.J. [University Medical Center Utrecht, Department of Internal Medicine (Section of Endocrinology), Utrecht (Netherlands); Meijer, F.J.A. [Radboud University Medical Center, Department of Radiology and Nuclear Medicine, Nijmegen (Netherlands); Lindert, Erik J. van [Radboud University Medical Center, Department of Neurosurgery, Nijmegen (Netherlands); Hermus, Ad [Radboud University Medical Center, Department of Internal Medicine (Section of Endocrinology), Nijmegen (Netherlands)

    2016-01-15

    To evaluate the detection of pituitary lesions at 7.0 T compared to 1.5 T MRI in 16 patients with clinically and biochemically proven Cushing's disease. In seven patients, no lesion was detected on the initial 1.5 T MRI, and in nine patients it was uncertain whether there was a lesion. Firstly, two readers assessed both 1.5 T and 7.0 T MRI examinations unpaired in a random order for the presence of lesions. Consensus reading with a third neuroradiologist was used to define final lesions in all MRIs. Secondly, surgical outcome was evaluated. A comparison was made between the lesions visualized with MRI and the lesions found during surgery in 9/16 patients. The interobserver agreement for lesion detection was good at 1.5 T MRI (κ = 0.69) and 7.0 T MRI (κ = 0.62). In five patients, both the 1.5 T and 7.0 T MRI enabled visualization of a lesion on the correct side of the pituitary gland. In three patients, 7.0 T MRI detected a lesion on the correct side of the pituitary gland, while no lesion was visible at 1.5 T MRI. The interobserver agreement of image assessment for 7.0 T MRI in patients with Cushing's disease was good, and lesions were detected more accurately with 7.0 T MRI. (orig.)

  18. High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing's disease

    International Nuclear Information System (INIS)

    Rotte, Alexandra A.J. de; Groenewegen, Amy; Rutgers, Dik R.; Witkamp, Theo; Luijten, Peter R.; Hendrikse, Jeroen; Zelissen, Pierre M.J.; Meijer, F.J.A.; Lindert, Erik J. van; Hermus, Ad

    2016-01-01

    To evaluate the detection of pituitary lesions at 7.0 T compared to 1.5 T MRI in 16 patients with clinically and biochemically proven Cushing's disease. In seven patients, no lesion was detected on the initial 1.5 T MRI, and in nine patients it was uncertain whether there was a lesion. Firstly, two readers assessed both 1.5 T and 7.0 T MRI examinations unpaired in a random order for the presence of lesions. Consensus reading with a third neuroradiologist was used to define final lesions in all MRIs. Secondly, surgical outcome was evaluated. A comparison was made between the lesions visualized with MRI and the lesions found during surgery in 9/16 patients. The interobserver agreement for lesion detection was good at 1.5 T MRI (κ = 0.69) and 7.0 T MRI (κ = 0.62). In five patients, both the 1.5 T and 7.0 T MRI enabled visualization of a lesion on the correct side of the pituitary gland. In three patients, 7.0 T MRI detected a lesion on the correct side of the pituitary gland, while no lesion was visible at 1.5 T MRI. The interobserver agreement of image assessment for 7.0 T MRI in patients with Cushing's disease was good, and lesions were detected more accurately with 7.0 T MRI. (orig.)

  19. Opportunity's View After Drive on Sol 1806 (Polar)

    Science.gov (United States)

    2009-01-01

    NASA's Mars Exploration Rover Opportunity used its navigation camera to take the images combined into this full-circle view of the rover's surroundings just after driving 60.86 meters (200 feet) on the 1,806th Martian day, or sol, of Opportunity's surface mission (Feb. 21, 2009). North is at the center; south at both ends. Tracks from the drive extend northward across dark-toned sand ripples and light-toned patches of exposed bedrock in the Meridiani Planum region of Mars. For scale, the distance between the parallel wheel tracks is about 1 meter (about 40 inches). Engineers designed the Sol 1806 drive to be driven backwards as a strategy to redistribute lubricant in the rovers wheels. The right-front wheel had been showing signs of increased friction. The rover's position after the Sol 1806 drive was about 2 kilometer (1.2 miles) south southwest of Victoria Crater. Cumulative odometry was 14.74 kilometers (9.16 miles) since landing in January 2004, including 2.96 kilometers (1.84 miles) since climbing out of Victoria Crater on the west side of the crater on Sol 1634 (August 28, 2008). This view is presented as a polar projection with geometric seam correction.

  20. Opportunity's View After Drive on Sol 1806

    Science.gov (United States)

    2009-01-01

    NASA's Mars Exploration Rover Opportunity used its navigation camera to take the images combined into this full-circle view of the rover's surroundings just after driving 60.86 meters (200 feet) on the 1,806th Martian day, or sol, of Opportunity's surface mission (Feb. 21, 2009). North is at the center; south at both ends. Tracks from the drive extend northward across dark-toned sand ripples and light-toned patches of exposed bedrock in the Meridiani Planum region of Mars. For scale, the distance between the parallel wheel tracks is about 1 meter (about 40 inches). Engineers designed the Sol 1806 drive to be driven backwards as a strategy to redistribute lubricant in the rovers wheels. The right-front wheel had been showing signs of increased friction. The rover's position after the Sol 1806 drive was about 2 kilometer (1.2 miles) south southwest of Victoria Crater. Cumulative odometry was 14.74 kilometers (9.16 miles) since landing in January 2004, including 2.96 kilometers (1.84 miles) since climbing out of Victoria Crater on the west side of the crater on Sol 1634 (August 28, 2008). This view is presented as a cylindrical projection with geometric seam correction.

  1. Opportunity's View After Drive on Sol 1806 (Vertical)

    Science.gov (United States)

    2009-01-01

    NASA's Mars Exploration Rover Opportunity used its navigation camera to take the images combined into this full-circle view of the rover's surroundings just after driving 60.86 meters (200 feet) on the 1,806th Martian day, or sol, of Opportunity's surface mission (Feb. 21, 2009). North is at the center; south at both ends. Tracks from the drive extend northward across dark-toned sand ripples and light-toned patches of exposed bedrock in the Meridiani Planum region of Mars. For scale, the distance between the parallel wheel tracks is about 1 meter (about 40 inches). Engineers designed the Sol 1806 drive to be driven backwards as a strategy to redistribute lubricant in the rovers wheels. The right-front wheel had been showing signs of increased friction. The rover's position after the Sol 1806 drive was about 2 kilometer (1.2 miles) south southwest of Victoria Crater. Cumulative odometry was 14.74 kilometers (9.16 miles) since landing in January 2004, including 2.96 kilometers (1.84 miles) since climbing out of Victoria Crater on the west side of the crater on Sol 1634 (August 28, 2008). This view is presented as a vertical projection with geometric seam correction.

  2. Abundancia y diversidad larval de gasterópodos en el Caribe Mexicano en relación con la temperatura, la salinidad y el oxígeno disuelto

    Directory of Open Access Journals (Sweden)

    José Francisco Chávez Villegas

    2014-09-01

    Full Text Available Quintana Roo tiene mas de 500 especies de gasterópodos pero muy poco se conoce de los estadios larvales. Muestreamos cuatro sitios mensualmente de enero a diciembre de 2008 con arrastres de plancton por triplicado y con una red cónica con malla de 300μm. Puerto Morelos tuvo los mayores registros (41.26±63.23 larvas•10m-3, seguido por Mahahual (14.78±28.21 larvas•10m-3, Sian Ka’an y Xel-Há presentaron las densidades menores (9.16±16.73 y 3.35±4.33 larvas•10m-3, respectivamente. Mayo y agosto presentaron los mayores registros (33.66±67.39 y 31.78±25.92 larvas•10m-3, respectivamente, marzo y diciembre los menores (1.70±1.88 y 3.18±5.27 larvas•10 m-3 respectivamente. Se registraron diferencias significativas en la densidad media espacial (p:<0.0001 y temporal (p: 0.0275. Identificamos un total de 33 especies de gasterópodos de los géneros Strombus, Natica, Cerithium, Nassarius, Neritidae, Cerithiopsis, Nannodiela, Rissoina, Bulla, Bittium, Modulus y Prunum, de las cuales 28 especies se registraron en Puerto Morelos. Natica, Epithonium y Cerithium fueron los géneros con mayor incidencia en las cuatro localidades.

  3. Stillbirth history and Toxoplasma gondii infection in women attending public health centers in a northern Mexican City

    Science.gov (United States)

    Alvarado-Esquivel, C.; Pacheco-Vega, S. J.; Salcedo-Jaquez, M.; Sánchez-Anguiano, L. F.; Hernández-Tinoco, J.; Rábago-Sánchez, E.; Centeno-Tinoco, M. M.; Flores-Garcia, I. D.; Ramos-Nevarez, A.; Cerrillo-Soto, S. M.; Guido-Arreola, C. A.; Beristain-García, I.; Liesenfeld, O.; Berumen-Segovia, L. O.; Saenz-Soto, L.; Sifuentes-Álvarez, A.

    2015-01-01

    Through a cross-sectional study design, 150 women attending public health centers with a history of stillbirths were examined for anti-Toxoplasma gondii IgG and IgM antibodies in Durango City, Mexico. Bivariate and multivariate analyses were used to assess the association of T. gondii seropositivity with the characteristics of the women with stillbirth history. Of the 150 women (mean age: 32.09 ± 9.16 years) studied, 14 (9.3%) had anti-T. gondii IgG antibodies and six (42.9%) of them were also positive for anti-T. gondii IgM antibodies. Multivariate analysis showed that T. gondii seropositivity was associated with high frequency (4–7 days a week) of eating meat (OR = 5.52; 95% CI: 1.48–20.59; P = 0.01), history of lymphadenopathy (OR = 4.52; 95% CI: 1.14–17.82; P = 0.03), and history of surgery (OR = 8.68; 95% CI: 1.04–72.15; P = 0.04). This is the first study on the seroepidemiology of T. gondii infection in women with a history of stillbirths in Mexico. The association of T. gondii exposure with a history of surgery warrants for further research. Risk factors for T. gondii infection found in the present survey may help to design optimal educational programs to avoid T. gondii infection. PMID:26185685

  4. The effect of self-directed virtual reality simulation on dissection training performance in mastoidectomy.

    Science.gov (United States)

    Andersen, Steven Arild Wuyts; Foghsgaard, Søren; Konge, Lars; Cayé-Thomasen, Per; Sørensen, Mads Sølvsten

    2016-08-01

    To establish the effect of self-directed virtual reality (VR) simulation training on cadaveric dissection training performance in mastoidectomy and the transferability of skills acquired in VR simulation training to the cadaveric dissection training setting. Prospective study. Two cohorts of 20 novice otorhinolaryngology residents received either self-directed VR simulation training before cadaveric dissection training or vice versa. Cadaveric and VR simulation performances were assessed using final-product analysis with three blinded expert raters. The group receiving VR simulation training before cadaveric dissection had a mean final-product score of 14.9 (95 % confidence interval [CI] [12.9-16.9]) compared with 9.8 (95% CI [8.4-11.1]) in the group not receiving VR simulation training before cadaveric dissection. This 52% increase in performance was statistically significantly (P performance (P = 0.22). Two hours of self-directed VR simulation training was effective in increasing cadaveric dissection mastoidectomy performance and suggests that mastoidectomy skills are transferable from VR simulation to the traditional dissection setting. Virtual reality simulation training can therefore be employed to optimize training, and can spare the use of donated material and instructional resources for more advanced training after basic competencies have been acquired in the VR simulation environment. NA. Laryngoscope, 126:1883-1888, 2016. © 2015 The American Laryngological, Rhinological and Otological Society, Inc.

  5. Fatty acid composition of bacteria associated with the toxic dinoflagellate Ostreopsis lenticularis and with Caribbean Palythoa species.

    Science.gov (United States)

    Carballeira, N M; Emiliano, A; Sostre, A; Restituyo, J A; González, I M; Colón, G M; Tosteson, C G; Tosteson, T R

    1998-06-01

    The fatty acid composition of a Pseudomonas sp. (Alteromonas) and its host, the dinoflagellate Ostreopsis lenticularis, vectors in ciguatera fish poisoning, has been studied. The major fatty acids in O. lenticularis were 16:0, 20:5n-3, and 22:6n-3, but 18:2n-6, 18:3n-3, and 18:n-3 were also identified. In contrast to other dinoflagellates, 1 8:5n-3 was not detected in O. lenticularis. Even-chain fatty acids such as 9-16:1, 11-18:1, and 13-20:1 predominated in the Pseudomonas sp. from O. lenticularis, but 1 6-20% of (E)-11-methyl-12-octadecenoic acid was also identified. The chirality of the latter was confirmed by total synthesis (28% overall yield) starting from oxacyclotridecan-2-one. The fatty acid compositions of two other Pseudomonas species, from the palytoxin-producing zoanthids Palythoa mamillosa and P. caribdea, were also studied and were similar to that of the Pseudomonas sp. from O. lenticularis. The possibility of using some of these fatty acids as chemotaxonomic lipids in identifying marine animals that consume toxic dinoflagellates or zoanthids is discussed.

  6. Monte Carlo modeling of the Yttrium-90 nanospheres application in the liver radionuclide therapy and organs doses calculation

    Directory of Open Access Journals (Sweden)

    Ghavami Seyed Mostafa

    2016-01-01

    Full Text Available Using the nano-scaled radionuclides in the radionuclide therapy significantly reduces the particles trapping in the organs vessels and avoids thrombosis formations. Additionally, uniform distribution in the target organ may be another benefit of the nanoradionuclides in the radionuclide therapy. Monte Carlo simulation was conducted to model a mathematical humanoid phantom and the liver cells of the simulated phantom were filled with the 90Y nanospheres. Healthy organs doses, fatal and nonfatal risks of the surrounding organs were estimated. The estimations and calculations were made in four different distribution patterns of the radionuclide seeds. Maximum doses and risks estimated for the surrounding organs were obtained in the high edge concentrated distribution model of the liver including the nanoradionuclides. For the dose equivalent, effective dose, fatal and non-fatal risks, the values obtained as 7.51E-03 Sv/Bq, 3.01E-01 Sv/Bq, and 9.16E-01 cases/104 persons for the bladder, colon, and kidney of the modeled phantom, respectively. The mentioned values were the maximum values among the studied modeled distributions. Maximum values of Normal Tissue Complication Probability for the healthy organs calculated as 5.9-8.9 %. Result of using nanoparticles of the 90Y provides promising dosimetric properties in MC simulation results considering non-toxicity reports for the radionuclide.

  7. Formulation of Gastric Floating System Using Bio-Sourced Terminalia Catappa Gum and in vivo Evaluation.

    Science.gov (United States)

    Meka, Venkata Srikanth; Murthy Kolapalli, Venkata Ramana

    2016-01-01

    A central composite design was applied to design a novel gastric floating drug delivery system comprising propranolol HCl in Terminalia catappa gum and to evaluate the buoyancy, in vitro drug release behavior, and pharmacokinetic parameters. All formulations exhibited good buoyancy properties in vitro reflected by floating lag time of 1-110 sec, total floating time of 9-16 h and prolonged release behaviour (upto 12 h). Statistically optimised formulation (PBGRso) was orally administered to human volunteers under both fasted and fed conditions to evaluate gastric floating behavior under different food conditions by X-ray evaluation. In vivo studies of optimised formulations revealed that the gastric residence time of floating tablets was enhanced in the fed but not in the fasted state. Pharmacokinetic studies of the optimised Terminalia catappa formulation and a commercial product (Ciplar LA 80) carried out on healthy human volunteers showed a significant improvement in the bioavailability (132%) of propranolol HCl released from from the experimental Terminalia catappa formulations compared with Ciplar LA 80.

  8. X-ray pixel detector for crystallography

    CERN Document Server

    Delpierre, P A; Blanquart, L; Caillot, B; Clemens, J C; Mouget, C

    2001-01-01

    For X-ray diffraction experiments, the required dynamic range is a challenge. The signal ranges usually over more than six orders of magnitude. To meet this requirement and to reduce the readout time with respect to the commonly used charge-coupled device camera, a dedicated hybrid pixel detector is under development. We have designed a new counting chip with pixel size of 330 mu m. The expected counting rate per pixel is 10/sup 7/ ph/s, and a continuous readout with time stamping will allow a dynamic range for up to 4*10 /sup 9/ (16-bit counter in each pixel and 16-bit counter per pixel in the readout boards). This chip has been submitted for fabrication and is under test. First results of this chip will be presented. As a first step, a small detector (4*1.6 cm/sup 2/) is being built, using a DELPHI(LEP/CERN) silicon array of diodes, which have good efficiency for collecting X-rays between 5 and 25 keV. After the electrical tests, the performance of this X-ray detector will be measured in the ESRF-D2AM beam ...

  9. Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies.

    Science.gov (United States)

    Vassy, Jason L; Shrader, Peter; Jonsson, Anna; Fox, Caroline S; Lyssenko, Valeriya; Isomaa, Bo; Groop, Leif; Meigs, James B; Franks, Paul W

    2011-08-01

    Parental history of diabetes and specific gene variants are risk factors for type 2 diabetes, but the extent to which these factors are associated is unknown. We examined the association between parental history of diabetes and a type 2 diabetes genetic risk score (GRS) in two cohort studies from Finland (population-based PPP-Botnia study) and the US (family-based Framingham Offspring Study). Mean (95% CI) GRS increased from 16.8 (16.8-16.9) to 16.9 (16.8-17.1) to 17.1 (16.8-17.4) among PPP-Botnia participants with 0, 1, and 2 parents with diabetes, respectively (p(trend)=0.03). The trend was similar among Framingham Offspring but was not statistically significant (p=0.07). The meta-analyzed p value for trend from the two studies was 0.005. The very modest associations reported above suggest that the increased risk of diabetes in offspring of parents with diabetes is largely the result of shared environmental/lifestyle factors and/or hitherto unknown genetic factors. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  10. Groin pain and hip range of motion is different in Indigenous compared to non-indigenous young Australian football players.

    Science.gov (United States)

    Taylor, Carolyn J; Pizzari, Tania; Ames, Nick; Orchard, John W; Gabbe, Belinda J; Cook, Jill L

    2011-07-01

    Hip and groin pain are common problems in Australian football. Although indigenous (I) players are at greater risk of soft tissue injury than their non-indigenous (non-I) counterparts, Aboriginal descent has not previously been identified as a risk factor for hip and groin injury. The aim of this study was to investigate if hip and groin screening tests would demonstrate differences between indigenous and non-indigenous junior elite AF players. Cross-sectional study. Two hundred and seventy elite junior Australian football players were screened using five hip and groin musculoskeletal tests. Thirty-three players (12%) were indigenous. Differences were demonstrated between the two groups for right prone hip internal rotation (I X = 27.60 ± 9.16, non-I X = 33.39 ± 8.88, p 0.001). The indigenous players displayed less range of passive hip internal rotation with the hip in neutral, reduced adductor squeeze force and higher levels of groin pain with the squeeze test at 90°. The differences observed between indigenous and non-indigenous players suggest indigenous players are at greater risk of hip and groin injuries in Australian football. Copyright © 2011 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  11. Comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry combined with solid phase microextraction as a powerful tool for quantification of ethyl carbamate in fortified wines. The case study of Madeira wine.

    Science.gov (United States)

    Perestrelo, Rosa; Petronilho, Sílvia; Câmara, José S; Rocha, Sílvia M

    2010-05-14

    An analytical methodology based on headspace solid phase microextraction (HS-SPME) combined with comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GC x GC-ToFMS) was developed for the identification and quantification of the toxic contaminant ethyl carbamate (EC) directly in fortified wines. The method performance was assessed for dry/medium dry and sweet/medium sweet model wines, and for quantification purposes, calibration plots were performed for both matrices using the ion extraction chromatography (IEC) mode (m/z 62). Good linearity was obtained with a regression coefficient (r(2)) higher than 0.981. A good precision was attained (R.S.D. wines. The quantification limits (LOQ) and recovery for dry wines were 14.38 microg/L and 88.6%, whereas for sweet wines were 9.16 microg/L and 99.4%, respectively. The higher performance was attained with sweet model wine, as increasing of glucose content improves the volatile compound in headspace, and a better linearity, recovery and precision were achieved. The analytical methodology was applied to analyse 20 fortified Madeira wines including different types of wine (dry, medium dry, sweet, and medium sweet) obtained from several harvests in Madeira Island (Portugal). The EC levels ranged from 54.1 microg/L (medium dry) to 162.5 microg/L (medium sweet). 2010 Elsevier B.V. All rights reserved.

  12. Severe Rebound-Associated Vertebral Fractures After Denosumab Discontinuation: 9 Clinical Cases Report.

    Science.gov (United States)

    Lamy, Olivier; Gonzalez-Rodriguez, Elena; Stoll, Delphine; Hans, Didier; Aubry-Rozier, Bérengère

    2017-02-01

    Denosumab inhibits bone resorption, increases bone mineral density, and reduces fracture risk. Denosumab was approved for the treatment of osteoporosis and the prevention of bone loss in some oncological situations. Denosumab discontinuation is associated with a severe bone turnover rebound (BTR) and a rapid loss of bone mineral density. The clinical consequences of the BTR observed after denosumab discontinuation are not known. We report 9 women who presented 50 rebound-associated vertebral fractures (RAVFs) after denosumab discontinuation. A broad biological and radiological assessment excluded other causes than osteoporosis. These 9 cases are unusual and disturbing for several reasons. First, all vertebral fractures (VFs) were spontaneous, and most patients had a high number of VFs (mean = 5.5) in a short period of time. Second, the fracture risk was low for most of these women. Third, their VFs occurred rapidly after last denosumab injection (9-16 months). Fourth, vertebroplasty was associated with a high number of new VFs. All the observed VFs seem to be related to denosumab discontinuation and unlikely to the underlying osteoporosis or osteopenia. We hypothesize that the severe BTR is involved in microdamage accumulation in trabecular bone and thus promotes VFs. Studies are urgently needed to determine 1) the pathophysiological processes involved, 2) the clinical profile of patients at risk for RAVFs, and 3) the management and/or treatment regimens after denosumab discontinuation. Health authorities, physicians, and patients must be aware of this RAVF risk. Denosumab injections must be scrupulously done every 6 months but not indefinitely.

  13. Globally Declining Population of Women Folk Causing Sex Imbalance Is a Serious Concern: An Analysis of Sex Ratio around the Globe

    Directory of Open Access Journals (Sweden)

    Rajesh K. Gautam

    2015-01-01

    Full Text Available Successful existence and perpetuation of any species depend on its reproductive success. In case of humans, the theoretical proportion of males and females should be 1 : 1, but this equilibrium was disturbed in many parts of the world. What are the determinants of sex imbalance in human should be found out to combat the problem. The data were gathered for 227 countries. The sex ratio for human population of the world was found 101 males for 100 females, but it varies from 74 to 219 among the countries. The number of countries having higher number of females as compared to males is 132, as they have 99 or less males per 100 females, whereas in 71 countries the total population of males is greater than the females. And only 24 countries have balanced sex ratio. Regression analysis shows that fertility, rate of natural increase, mortality, and gender inequality index have inverse effect, and they account for 24.4%, 23.1%, 18.8%, 18.9%, 16.3%, 16.1%, and 5.1% of variability, respectively. There is great need to identify such countries and region where sex selective abortion is being practiced and to find out appropriate strategies to combat such problem.

  14. Evaluation of the Roche LightMix®Gastro Parasites multiplex PCR assay detecting Giardia duodenalis, Entamoeba histolytica, cryptosporidia, Dientamoeba fragilis, and Blastocystis hominis.

    Science.gov (United States)

    Friesen, Johannes; Fuhrmann, Jörg; Kietzmann, Heike; Tannich, Egbert; Müller, Michael; Ignatius, Ralf

    2018-03-23

    Multiplex PCR assays offer highly sensitive and specific tools for the detection of enteric pathogens. This prospective study aimed at comparing the novel Roche LightMix ® Modular Assay Gastro Parasites (LMAGP) detecting Giardia duodenalis, Entamoeba histolytica, Cryptosporidium spp., Blastocystis hominis, and Dientamoeba fragilis with routine laboratory procedures. Stool specimens (n=1062 from 1009 patients) were consecutively examined by LMAGP, R-Biopharm Ridascreen ® enzyme immunoassays (EIAs) detecting G. duodenalis or E. histolytica/dispar, and microscopy of wet mounts. Discrepant results were analyzed by in-house PCR. D. fragilis or B. hominis were detected by LMAGP in 131 (14.4%) and 179 (19.9%; 16 samples positive by microscopy; P PCR). G. duodenalis was detected by LMAGP, EIA, or microscopy in 20, 16, or 9 of 1039 stool samples, respectively; all four samples missed by EIA were confirmed by in-house PCR. In total, 938 stool samples were analyzed for E. histolytica/dispar. Nine of ten EIA-positive samples were negative by LMAGP but positive by in-house PCR for E. dispar. One E. histolytica infection (positive by both LMAGP and in-house PCR) was missed by EIA and microscopy. Parasites only detected by microscopy included Enterobius vermicularis eggs (n = 3) and apathogenic amoebae (n = 27). The data call for routine use of multiplex PCR assays for the detection of enteric protozoan parasites in laboratory diagnostics. Copyright © 2018. Published by Elsevier Ltd.

  15. MID-INFRARED SPECTROSCOPY OF HIGH-REDSHIFT 3CRR SOURCES

    International Nuclear Information System (INIS)

    Leipski, C.; Antonucci, R.; Haas, M.; Chini, R.; Heymann, F.; Willner, S. P.; Ashby, M. L. N.; Wilkes, B. J.; Fazio, G. G.; Barthel, P.; Siebenmorgen, R.; Ogle, P.

    2010-01-01

    Using the Spitzer Space Telescope, we have obtained rest-frame 9-16 μm spectra of 11 quasars and 9 radio galaxies from the 3CRR catalog at redshifts 1.0 9.7μm = 1.1) whereas the mean quasar spectrum shows silicates in emission. The mean radio-galaxy spectrum matches a dust-absorbed mean quasar spectrum in both shape and overall flux level. The data for individual objects conform to these results. The trend of the silicate depth to increase with decreasing core fraction of the radio source further supports that for this sample orientation is the main driver for the difference between radio galaxies and quasars, as predicted by AGN unification. However, comparing our high-z sample with lower redshift 3CRR objects reveals that the absorption of the high-z radio galaxy MIR continuum is lower than expected from a scaled-up version of lower luminosity sources, and we discuss some effects that may explain these trends.

  16. Portal annular pancreas: a systematic review of a clinical challenge.

    Science.gov (United States)

    Harnoss, Jonathan M; Harnoss, Julian C; Diener, Markus K; Contin, Pietro; Ulrich, Alexis B; Büchler, Markus W; Schmitz-Winnenthal, Friedrich H

    2014-10-01

    Portal annular pancreas (PAP) is an asymptomatic congenital pancreas anomaly, in which portal and/or mesenteric veins are encased by pancreas tissue. The aim of the study was to determine the role of PAP in pancreatic surgery as well as its management and potential complication, specifically, postoperative pancreatic fistula (POPF).On the basis of a case report, the MEDLINE and ISI Web of Science databases were systematically reviewed up to September 2012. All articles describing a case of PAP were considered.In summary, 21 studies with 59 cases were included. The overall prevalence of PAP was 2.4% and the patients' mean (SD) age was 55.9 (16.2) years. The POPF rate in patients with PAP (12 pancreaticoduodenectomies and 3 distal pancreatectomies) was 46.7% (in accordance with the definition of the International Study Group of Pancreatic Surgery).Portal annular pancreas is a quite unattended pancreatic variant with high prevalence and therefore still remains a clinical challenge to avoid postoperative complications. To decrease the risk for POPF, attentive preoperative diagnostics should also focus on PAP. In pancreaticoduodenectomy, a shift of the resection plane to the pancreas tail should be considered; in extensive pancreatectomy, coverage of the pancreatic remnant by the falciform ligament could be a treatment option.

  17. Miastenia grave: avaliação clinica e terapêutica de 55 casos

    Directory of Open Access Journals (Sweden)

    Lineu Cesar Werneck

    1987-12-01

    Full Text Available Foram estudados 55 casos de miastenia grave, avaliando os sinais e sintomas clínicos que ocorreram no início e na evolução dos pacientes, bem como os procedimentos diagnósticos e avaliação das medidas terapêuticas utilizadas. No manejo dos pacientes foram utilizados anticolinesterásicos, corticoesteróides, azathioprina, plasmaferese e timectomia, sem que fosse possível encontrar relação estatística significante entre os diferentes procedimentos com respeito à resolução da doença. Dos 55 casos, 9 (16,6% obtiveram remissão total, 41 (74,5% permaneceram com a doença ativa necessitando de tratamento sintomático e 5 (9.09% faleceram. Houve relação estatística significante entre os sinais de insuficiência respiratória, crises miastênicas e timoma somente no grupo de pacientes que faleceram (um por insuficiência respiratória restritiva secundária a cifoescoliose severa, três com timoma e um caso durante a timectomia.

  18. Spectrum of pediatric neuromyelitis optica.

    Science.gov (United States)

    Lotze, Timothy E; Northrop, Jennifer L; Hutton, George J; Ross, Benjamin; Schiffman, Jade S; Hunter, Jill V

    2008-11-01

    Our goal was to describe the spectrum of clinical phenotypes, laboratory and imaging features, and treatment in pediatric patients with neuromyelitis optica. The study consisted of a retrospective chart review of patients followed in a pediatric multiple sclerosis center with a diagnosis of neuromyelitis optica spectrum disorder. Nine patients with neuromyelitis optica spectrum disorders were included, all of whom were female. There were 4 black children, 2 Latin American children, 2 white children, and 1 child of mixed Latin American/white heritage. Median age at initial attack was 14 years (range: 1.9-16 years). Median disease duration was 4 years (range: 0.6-9 years). Tests for neuromyelitis optica immunoglobulin G were positive for 7 patients. Eight patients had transverse myelitis and optic neuritis, and 1 patient had longitudinally extensive transverse myelitis without optic neuritis but had a positive neuromyelitis optica immunoglobulin G antibody titer. Cerebral involvement on MRI was found in all subjects, 5 of whom were symptomatic with encephalopathy, seizures, hemiparesis, aphasia, vomiting, or hiccups. Immunosuppressive therapy reduced attack frequency and progression of disability. Pediatric neuromyelitis optica has a diverse clinical presentation and may be difficult to distinguish from multiple sclerosis in the early stages of the disease. The recognition of the broad spectrum of this disease to include signs and symptoms of brain involvement is aided by the availability of a serum biomarker: neuromyelitis optica immunoglobulin G. Early diagnosis and immunosuppresive treatment may help to slow the accumulation of severe disability.

  19. More than just physical activity: time use clusters and profiles of Australian youth.

    Science.gov (United States)

    Ferrar, Katia; Olds, Tim; Maher, Carol

    2013-09-01

    To describe time use clusters and correlate-cluster profiles of Australian youth. Secondary analysis of cross-sectional national survey. Data were from the National Children's Nutrition and Physical Activity Survey, a random sample (n=1853) of 9-16 years old Australians (February-August 2007). Time use data were collected using the Multimedia Activity Recall for Children and Adults, and collapsed into 17 age-adjusted variables for sex-specific cluster analysis. Cluster associations with socio-demographic, anthropometric, health and dietary variables were analysed. For boys (n=930), the Social tasker cluster was characterised by social interaction and chores & work, the Techno-active cluster by team sport and TV and the Techno-studious cluster by video games and study. Average daily pedometer steps, age and remoteness were significant cluster correlates. For the girls (n=923), the Social screenie cluster was characterised by TV and social interaction, the Quiet actives cluster by quiet time and non-team sport and the Techno-studious cluster by video games and study. Pedometer steps, age, parental income and education, parent-child age difference, "extra foods", fat and fruit intakes were significant correlates. Distinct sex-specific time use clusters and profiles exist among Australian youth. These findings may assist the development of targeted time use interventions to improve health and well-being. Copyright © 2012 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  20. Clinical features and risk factors of cerebral infarction after mild head trauma under 18 months of age.

    Science.gov (United States)

    Yang, Feng-Hua; Wang, Hua; Zhang, Jun-Mei; Liang, Hong-Yuan

    2013-03-01

    Mild head trauma can cause cerebral infarction in children younger than 18 months of age, yet the pathogenesis, clinical characteristics, and risk factors are not fully understood. Data of 16 cases between August 2008 and September 2011, including clinical manifestations and imaging and laboratory findings were collected and analyzed. All patients had the history of mild head trauma. The median age of the cohort was 13.5 months (range 6 months to 18 months). All children developed neurologic symptoms and signs within 72 hours after trauma, 62.5% (10/16) within 30 minutes. The first symptoms included hemiparesis (9/16), facial paresis (4/16), and convulsion (6/16). Overall, 93.75% (15/16) of the lesions were in the basal ganglia region. Two risk factors were identified, basal ganglia calcification in 10 and cytomegalovirus infection in eight. After conservative therapy, the neurologic deficits recovered to some extent. Cerebral infarction after mild head trauma in children younger than 18 months of age may take place, especially under the circumstances of basal ganglia calcification or cytomegalovirus infection. Copyright © 2013 Elsevier Inc. All rights reserved.

  1. RAPD analysis of the genetic diversity of mango (Mangifera indica) germplasm in Brazil.

    Science.gov (United States)

    Souza, I G B; Valente, S E S; Britto, F B; de Souza, V A B; Lima, P S C

    2011-12-14

    We evaluated genetic variability of mango (Mangifera indica) accessions maintained in the Active Germplasm Bank of Embrapa Meio-Norte in Teresina, Piauí, Brazil, using RAPDs. Among these accessions, 35 originated from plantings in Brazil, six from the USA and one from India. Genomic DNA, extracted from leaf material using a commercial purification kit, was subjected to PCR with the primers A01, A09, G03, G10, N05, and M16. Fifty-five polymorphic loci were identified, with mean of 9.16 ± 3.31 bands per primer and 100% polymorphism. Application of unweighted pair group method using arithmetic average cluster analysis demonstrated five genotypic groups among the accessions examined. The genotypes Rosa 41, Rosa 48 and Rosa 49 were highly similar (94% similarity), whereas genotypes Sensation and Rosa 18 were the most divergent (only 7% similarity). The mango accessions were found to have considerable genetic variability, demonstrating the importance of analyzing each genotype in a collection in order to efficiently maintain the germplasm collection.

  2. Subcellular Targeting of Nine Calcium-Dependent Protein Kinase Isoforms from Arabidopsis1

    Science.gov (United States)

    Dammann, Christian; Ichida, Audrey; Hong, Bimei; Romanowsky, Shawn M.; Hrabak, Estelle M.; Harmon, Alice C.; Pickard, Barbara G.; Harper, Jeffrey F.

    2003-01-01

    Calcium-dependent protein kinases (CDPKs) are specific to plants and some protists. Their activation by calcium makes them important switches for the transduction of intracellular calcium signals. Here, we identify the subcellular targeting potentials for nine CDPK isoforms from Arabidopsis, as determined by expression of green fluorescent protein (GFP) fusions in transgenic plants. Subcellular locations were determined by fluorescence microscopy in cells near the root tip. Isoforms AtCPK3-GFP and AtCPK4-GFP showed a nuclear and cytosolic distribution similar to that of free GFP. Membrane fractionation experiments confirmed that these isoforms were primarily soluble. A membrane association was observed for AtCPKs 1, 7, 8, 9, 16, 21, and 28, based on imaging and membrane fractionation experiments. This correlates with the presence of potential N-terminal acylation sites, consistent with acylation as an important factor in membrane association. All but one of the membrane-associated isoforms targeted exclusively to the plasma membrane. The exception was AtCPK1-GFP, which targeted to peroxisomes, as determined by covisualization with a peroxisome marker. Peroxisome targeting of AtCPK1-GFP was disrupted by a deletion of two potential N-terminal acylation sites. The observation of a peroxisome-located CDPK suggests a mechanism for calcium regulation of peroxisomal functions involved in oxidative stress and lipid metabolism. PMID:12913141

  3. Subcellular targeting of nine calcium-dependent protein kinase isoforms from Arabidopsis

    Science.gov (United States)

    Dammann, Christian; Ichida, Audrey; Hong, Bimei; Romanowsky, Shawn M.; Hrabak, Estelle M.; Harmon, Alice C.; Pickard, Barbara G.; Harper, Jeffrey F.; Evans, M. L. (Principal Investigator)

    2003-01-01

    Calcium-dependent protein kinases (CDPKs) are specific to plants and some protists. Their activation by calcium makes them important switches for the transduction of intracellular calcium signals. Here, we identify the subcellular targeting potentials for nine CDPK isoforms from Arabidopsis, as determined by expression of green fluorescent protein (GFP) fusions in transgenic plants. Subcellular locations were determined by fluorescence microscopy in cells near the root tip. Isoforms AtCPK3-GFP and AtCPK4-GFP showed a nuclear and cytosolic distribution similar to that of free GFP. Membrane fractionation experiments confirmed that these isoforms were primarily soluble. A membrane association was observed for AtCPKs 1, 7, 8, 9, 16, 21, and 28, based on imaging and membrane fractionation experiments. This correlates with the presence of potential N-terminal acylation sites, consistent with acylation as an important factor in membrane association. All but one of the membrane-associated isoforms targeted exclusively to the plasma membrane. The exception was AtCPK1-GFP, which targeted to peroxisomes, as determined by covisualization with a peroxisome marker. Peroxisome targeting of AtCPK1-GFP was disrupted by a deletion of two potential N-terminal acylation sites. The observation of a peroxisome-located CDPK suggests a mechanism for calcium regulation of peroxisomal functions involved in oxidative stress and lipid metabolism.

  4. Ultrastructural characteristics of spermatogenesis in Pallas's mastiff bat, Molossus molossus (Chiroptera: Molossidae).

    Science.gov (United States)

    Beguelini, Mateus R; Taboga, Sebastião R; Morielle-Versute, Eliana

    2012-07-01

    Despite the large number of species, their wide distribution, and unique reproductive characteristics, Neotropical bats have been poorly studied, and important aspects of the reproduction of these animals have not been elucidated. We made an ultrastructural analysis of spermatogenesis in Molossus molossus (Molossidae). The process of spermatogonial differentiation is similar to that found in other bats and is also relatively similar to that of Primates, with three main spermatogonia types: A(d), A(p), and B. Meiotic divisions proceed similarly to those of most mammals, and spermiogenesis is clearly divided into 12 steps, in the middle of the range known for bats (9-16 steps). Formation of the acrosome is similar to that known from other mammals; however, the ultrastructure of spermatozoa was found to have unique characteristics, including many wavy acrosomal projections on its surface, which seems to be specific for the family Molossidae. Comparing the ultrastructure of the spermatozoon of M. molossus with other bats already study, we observed that three characters vary: morphology of the outer dense fibers, of the perforatorium, and of the spermatozoon head. The great similarity of morphological characters between M. molossus and Platyrrhinus lineatus suggests that M. molossus is more closely related to the Phyllostomidae than to the Rhinolophidae and the Vespertilionidae. Copyright © 2012 Wiley Periodicals, Inc.

  5. Evaluation of the causes of the exams repetition in a mammography service; Avaliacao das causas de repeticoes realizadas em um servico de mamografia

    Energy Technology Data Exchange (ETDEWEB)

    Padilha Filho, L.G.; Pereira, W.W.; Montone Junior, V.; Beskow, R.LK.; Berquo, F.R.; Chernicharo, C.C.; Lins, R.P.N. [Fundacao Tecnico Educacional Souza Marques, Rio de Janeiro, RJ (Brazil)]. E-mail: lupadilha@ajato.com.br; Petrelli, A. dos S.C.; Santos, R.P. [Santa Casa de Misericordia do Rio de Janeiro, RJ (Brazil). Centro de Diagnostico Mamario

    2001-07-01

    The objective of this work is to evaluate and become clear the causes of repetitions of the mammography centre of the Santa Casa da Misericordia do Rio de Janeiro (CDM/SCMRJ). This will become possible to make the necessary modifications to a better learning to the residents of CDM/SCMRJ and also to the students of medical physics of Fundacao Tecnico Educacional Souza Marques. During the period of 2001 April to 2001 July, 131 rejections from a total of 3936 mammography's exams over patients from CDM/SCMRJ, taking in consideration, the mistakes over confection of mammography. The obtained results show in a preliminary evaluation that from 131 utilized films, the more frequent mistakes were 29% from the positioning; 16.79% from radiographic artifacts; 9.16% from sub-exposition; 8.39% from inadequate techniques; 8.39% from overcast. The majority of rejected films happened during a clinical phase of radiographic confection, this shows that the efforts that have been done in the teaching and training from technicians and residents must be accentuated yet more to diminished these wrongs. The conditions of functioning are in the domain of preconization rules for a good radiographic analysis. (author)

  6. The role of smartphones in increasing digital and social inequalities among Romanian children

    Directory of Open Access Journals (Sweden)

    Bianca Balea

    2016-12-01

    Full Text Available he emergence of new mobile devices such as Smartphones and tablets in children’s everyday life has facilitated the rise of Internet private use among them, making it possible for them to go online at anytime and anywhere. As studies show, ownership and private use of a Smartphone shape the quality of children’s online experience in a meaningful way (Mascheroni & Cuman, 2014. Accordingly, a broader range of access locations and devices relates to more unsupervised access and thus more independent use of the Internet, which are likely to be related to higher skill levels. This paper aims to investigate, using linear and multilinear regressions, whether owning or having access to Smartphones leads to increasing digital inequalities among children. Results show that demographic variables are significant predictors for the level of Smartphone related skills. However, when variables related with children’s Smartphone and Internet use are introduced in the model, the influence of demographic variables is reduced, showing evidence for second-level of digital divide among children. The present study reports on the Net Children Go Mobile dataset. The project collected data in 2013 from random stratified survey samples of around 500 children aged 9-16, who are Internet users, in seven European country, including Romania. For the purpose of this paper, only responses from Romanian children were taken into account (N=522.

  7. Chitinilyticum aquatile gen. nov., sp. nov., a chitinolytic bacterium isolated from a freshwater pond used for Pacific white shrimp culture.

    Science.gov (United States)

    Chang, Shu-Chen; Chen, Wen-Ming; Wang, Jih-Terng; Wu, Ming-Chang

    2007-12-01

    Strain c14(T), originally isolated from surface water of a freshwater pond located in Pingtung (southern Taiwan) used for culture of Pacific white shrimp (Litopenaeus vannamei), was subjected to a polyphasic taxonomic approach. The strain exhibited strong chitinolytic activity and was able to grow under aerobic and anaerobic conditions by utilizing chitin exclusively as the carbon, nitrogen and energy source. Phylogenetic analysis of the 16S rRNA gene sequence revealed a clear affiliation of the proposed bacterium to the Betaproteobacteria, most closely related to Chitinibacter tainanensis S1(T), Deefgea rivuli WB 3.4-79(T) and Silvimonas terrae KM-45(T), with 94.6, 93.6 and 92.9 % 16S rRNA gene sequence similarity, respectively. The predominant fatty acids detected in cells of strain c14(T) were C(16 : 0), C(18 : 1)omega7c and summed feature 3 (C(16 : 1)omega7c and/or C(15 : 0) iso 2-OH). The G+C content of the genomic DNA was 69.5 (+/-1.0) mol%. Biochemical, physiological, chemotaxonomic and phylogenetic analyses showed that strain c14(T) could not be assigned to any known genus of the Betaproteobacteria. Therefore, strain c14(T) is classified within a novel genus and species, for which the name Chitinilyticum aquatile gen. nov., sp. nov. is proposed. The type strain of Chitinilyticum aquatile is c14(T) (=LMG 23346(T) =BCRC 17533(T)).

  8. Am I normal? A systematic review and construction of nomograms for flaccid and erect penis length and circumference in up to 15,521 men.

    Science.gov (United States)

    Veale, David; Miles, Sarah; Bramley, Sally; Muir, Gordon; Hodsoll, John

    2015-06-01

    To systematically review and create nomograms of flaccid and erect penile size measurements. Study key eligibility criteria: measurement of penis size by a health professional using a standard procedure; a minimum of 50 participants per sample. samples with a congenital or acquired penile abnormality, previous surgery, complaint of small penis size or erectile dysfunction. Synthesis methods: calculation of a weighted mean and pooled standard deviation (SD) and simulation of 20,000 observations from the normal distribution to generate nomograms of penis size. Nomograms for flaccid pendulous [n = 10,704, mean (SD) 9.16 (1.57) cm] and stretched length [n = 14,160, mean (SD) 13.24 (1.89) cm], erect length [n = 692, mean (SD) 13.12 (1.66) cm], flaccid circumference [n = 9407, mean (SD) 9.31 (0.90) cm], and erect circumference [n = 381, mean (SD) 11.66 (1.10) cm] were constructed. Consistent and strongest significant correlation was between flaccid stretched or erect length and height, which ranged from r = 0.2 to 0.6. relatively few erect measurements were conducted in a clinical setting and the greatest variability between studies was seen with flaccid stretched length. Penis size nomograms may be useful in clinical and therapeutic settings to counsel men and for academic research. © 2014 The Authors. BJU International © 2014 BJU International.

  9. Infertility and Weight Reduction: Influence and Outcome

    International Nuclear Information System (INIS)

    Khaskheli, M. N.; Baloch, S.; Baloch, A. S.

    2013-01-01

    Objective: To assess the effect of weight reduction in obese infertile women on conception rate spontaneously as well as with ovulation induction and pregnancy outcome. Study Design: Observational experimental study. Place and Duration of Study: Different private clinics at Mirpurkhas, Thana Bola Khan and Hyderabad, Sindh, Pakistan, from March 2008 to February 2011. Methodology: Infertile women who were obese with the body mass index (BMI) > 30 kg/ m2 and failed to conceive within 2-5 years after taking treatment of infertility for many cycles were inducted. These women underwent life style change program related to exercise and diet for 6 months and in the next 6 months they were observed for spontaneous conception. Those women who failed to conceive were prescribed ovulation induction (clomifene citrate) for the next 6 months and were observed for conception. After conception, they visited regularly during antenatal period till delivery. The data was collected and analyzed on SPSS version 17. Results: The mean decrease in the body index observed was 9.6 +- 1.23 kg/m2, spontaneous conception rate was (n = 35, 41.17%) and miscarriage rate was (n = 9, 16.66%). Conclusion: Weight reduction leads to high spontaneous conception rate as well as with ovulation induction therapy and improves the pregnancy outcome. (author)

  10. Optimization of a new animal glue binder system cured by CO2 for use in foundry

    Directory of Open Access Journals (Sweden)

    Liu Weihua

    2012-11-01

    Full Text Available A new sand binder system cured by CO2 was prepared based on the animal bone glue. To overcome the disadvantages of animal glue such as agglomeration at room temperature, high energy consumption and low efficiency, an alkaline decomposition process was selected, and certain modifier was used to modify the performance of the animal glue binder. For the alkaline decomposition, NaOH was used as the catalyst with an addition of 4wt.% to the animal glue. A modifier was determined through the orthogonal experiment with a weight ratio of glycerin: glycol: dextrin: animal glue = 9:16:15:100, and the optimal modification reaction should be performed at 75 ℃ with a reaction time of 90 min. Ca(OH2 was used as a promoter; the optimal CO2 gas flux blowing into the sand was 0.7 m3·h-1 for a duration of 60 s under the experimental conditions. Results show that an original strength above 0.7 MPa and a final strength about 4.2 MPa can be achieved, which could meet the requirement of rapid moulding and core-making for foundry. The new binder was characterized and analyzed by means of IR, and the modification and CO2-cured mechanisms of this animal glue binder were also discussed.

  11. Fetal Stomach Position Predicts Neonatal Outcomes in Isolated Left-Sided Congenital Diaphragmatic Hernia.

    Science.gov (United States)

    Basta, Amaya M; Lusk, Leslie A; Keller, Roberta L; Filly, Roy A

    2016-01-01

    We sought to determine the relationship between the degree of stomach herniation by antenatal sonography and neonatal outcomes in fetuses with isolated left-sided congenital diaphragmatic hernia (CDH). We retrospectively reviewed neonatal medical records and antenatal sonography of fetuses with isolated left CDH cared for at a single institution (2000-2012). Fetal stomach position was classified on sonography as follows: intra-abdominal, anterior left chest, mid-to-posterior left chest, or retrocardiac (right chest). Ninety fetuses were included with 70% surviving to neonatal discharge. Stomach position was intra-abdominal in 14% (n = 13), anterior left chest in 19% (n = 17), mid-to-posterior left chest in 41% (n = 37), and retrocardiac in 26% (n = 23). Increasingly abnormal stomach position was linearly associated with an increased odds of death (OR 4.8, 95% CI 2.1-10.9), extracorporeal membrane oxygenation (ECMO; OR 5.6, 95% CI 1.9-16.7), nonprimary diaphragmatic repair (OR 2.7, 95% CI 1.4-5.5), prolonged mechanical ventilation (OR 5.9, 95% CI 2.3-15.6), and prolonged respiratory support (OR 4.0, 95% CI 1.6-9.9). All fetuses with intra-abdominal stomach position survived without substantial respiratory morbidity or need for ECMO. Fetal stomach position is strongly associated with neonatal outcomes in isolated left CDH. This objective tool may allow for accurate prognostication in a variety of clinical settings. © 2015 S. Karger AG, Basel.

  12. Electronic control of different generation regimes in mode-locked all-fibre F8 laser

    Science.gov (United States)

    Kobtsev, Sergey; Ivanenko, Aleksey; Kokhanovskiy, Alexey; Smirnov, Sergey

    2018-04-01

    We demonstrate for the first time an electronically controlled realisation of markedly different generation regimes in a mode-locked all-fibre figure-eight (F8) Yb-doped laser. Electronic adjustment of the ratio of pumping powers of two amplification stages in a nonlinear amplifying loop mirror enables the establishment of stable pulse generation regimes with different degrees of coherence and control over their parameters within relatively broad limits, with the pulse duration range exceeding a factor of two in the picosecond domain for coherent and incoherent pulses, the energy range exceeding an order of magnitude for incoherent pulses (2.2-24.8 nJ) and over a factor of 8 for coherent pulses (1.9-16.2 nJ). Adjustment of the pumping powers allows one to maintain the duration of the coherent pulses and to set their peak power in the range of 32.5-292.5 W. The proposed configuration of electronic control over the radiation parameters of a mode-locked all-fibre F8 laser enables reproducible generation of pulses of different types with specified parameters within a broad range of values.

  13. Peripartum cardiomyopathy – case series

    Science.gov (United States)

    Prasad, Gowri Sayi; Bhupali, Ashok; Prasad, Sayi; Patil, Ajit N.; Deka, Yashodhan

    2014-01-01

    Objectives To study the pattern of presentation, course of disease and outcome of pregnancy in Peripartum Cardiomyopathy. Methods A prospective study of sixteen cases of PPCM was conducted at Apple Saraswati Multispecialty Hospital and Dr. D.Y. Patil Medical College and Hospital, Kolhapur, Maharashtra, India from January 2006 to December 2012. Data included age distribution, parity, gestational age, symptoms and risk factors. Medical management and pregnancy outcome were documented. Serial echocardiography data was compiled for a period of one year. Results In our study 9/16 (56%) were primigravidae, 4/16 (25%) had pre-eclamsia and 6/16 (35%) had co-existing hypertension. The difference in Echocardiography parameters observed between recovered and non-recovered patients was significant: Left Ventricular End diastolic dimension (5.6 cm vs 6.06 cm), Left Ventricular Ejection Fraction (28.7% vs 22.4%) and Left Ventricular fractional shortening (17.5% vs 13.4%). Thirteen out of sixteen patients were followed up for a period of one year out of which 61% (8/13) patients recovered completely. There was one mortality. Conclusion PPCM is a diagnosis of exclusion. Majority were young primigravidae presenting postnatally. Pre-eclampsia and hypertension were risk factors. ECHO parameters were reliable predictors of recovery. Future pregnancies are better avoided. PMID:24814122

  14. Peripartum cardiomyopathy - case series.

    Science.gov (United States)

    Prasad, Gowri Sayi; Bhupali, Ashok; Prasad, Sayi; Patil, Ajit N; Deka, Yashodhan

    2014-01-01

    To study the pattern of presentation, course of disease and outcome of pregnancy in Peripartum Cardiomyopathy. A prospective study of sixteen cases of PPCM was conducted at Apple Saraswati Multispecialty Hospital and Dr. D.Y. Patil Medical College and Hospital, Kolhapur, Maharashtra, India from January 2006 to December 2012. Data included age distribution, parity, gestational age, symptoms and risk factors. Medical management and pregnancy outcome were documented. Serial echocardiography data was compiled for a period of one year. In our study 9/16 (56%) were primigravidae, 4/16 (25%) had pre-eclamsia and 6/16 (35%) had co-existing hypertension. The difference in Echocardiography parameters observed between recovered and non-recovered patients was significant: Left Ventricular End diastolic dimension (5.6 cm vs 6.06 cm), Left Ventricular Ejection Fraction (28.7% vs 22.4%) and Left Ventricular fractional shortening (17.5% vs 13.4%). Thirteen out of sixteen patients were followed up for a period of one year out of which 61% (8/13) patients recovered completely. There was one mortality. PPCM is a diagnosis of exclusion. Majority were young primigravidae presenting postnatally. Pre-eclampsia and hypertension were risk factors. ECHO parameters were reliable predictors of recovery. Future pregnancies are better avoided. Copyright © 2014 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.

  15. Online on the mobile: internet use on the smartphone and associated risks among youth in Europe

    DEFF Research Database (Denmark)

    Stald, Gitte Bang; Green, Leila; Barbowski, Monica

    2014-01-01

    1. This report analyses how children aged 9-16 changed their internet use between 2010, when most children used fixed computers and laptops, and 2013, with over one-quarter (c. 28%) of 9-12 year olds, and three-fifths (c. 60%) of 13-16 year olds, accessing the internet via a smartphone. 2. Children...... experience slightly increased risk when accessing the internet via a smartphone or tablet. Historically, such children came from richer, more privileged backgrounds, and spent more time online: all linked with risk exposure. Now that most 13-16 year olds have smartphones, they are no longer an elite. Along...... with extra risk, children with smartphones access the internet more often, engage in a greater range of activities, and have a higher number of skills. 3. The likelihood of children experiencing three or more risks has not changed greatly between 2010 and 2013, except for a rise in the 9-10 age group (from 1...

  16. Disposal rate in different age groups of Karan Fries (Crossbred) males in organized herd.

    Science.gov (United States)

    Panmei, Achun; Gupta, A K; Shivahre, P R; Bhakat, M; Singh, K Mahesh

    2015-02-01

    The present study was carried out to analyze the disposal rate in different age groups of Karan Fries (KF) males in National Dairy Research Institute herd. Records on 1740 KF crossbred bulls born during the period 1997-2012 were collected with an objective to ascertain the effect of genetic and non-genetic (Period of birth and season of birth) factors on the disposal pattern of KF males. The percent of animals disposed from the herd due to mortality and culling was calculated by proportion using descriptive statistics. The data were subjected to Chi-square test to test the difference due to different factors. Overall disposal rate for the different age groups of 0-1 m, 1-2 m, 2-3 m, 3-6 m, 6-18 m, 18 m-3 year and 3-5 year were calculated as 17.9, 16.3, 14.2, 25.8, 49.0, 37.6 and 51.65%, respectively. In the age groups, 3-6 m, 6-18 m and 3-5 year, effect of periods of birth were found to be statistically significant (page group except in 3-5 year age group. Differences in overall disposal rate due to genetic group were statistically significant (page groups. Overview of the results indicated that higher overall disposal rate in age group of 1 month was due to mortality while, in the age groups of >1 month, culling was the primary cause.

  17. Absence of activating mutations in ras and gsp oncogenes in a cohort of nine patients with sporadic pediatric thyroid tumors.

    Science.gov (United States)

    Pauws, E; Tummers, R F; Ris-Stalpers, C; de Vijlder, J J; Voûte, T

    2001-06-01

    Characterization of the genetic background of pediatric thyroid carcinomas could aid in distinguishing between differently staged tumors with respect to treatment and prognosis. Two known genetic factors associated with thyroid carcinoma, the proto-oncogenes gsp and ras were investigated. DNA was extracted from paraffin sections from both tumor and normal thyroid tissue of nine patients (ages 9-16 years). Of these patients, eight were diagnosed with papillary carcinoma and one with follicular adenoma. The coding exons of gsp and the three known ras genes (H, K, and N-ras) were screened for mutations using SSCP-analysis. There were no mutations present in the ras and gsp proto-oncogenes hot spots, however, LOH of H-ras (chromosome location 11p15.5) was found in tumor tissue from one patient and a homozygous mutation in exon 12 of gsp causing a Pro-->Ser conversion was present in the thyroid tumor tissue from another patient. Two silent polymorphisms were detected, H-ras exon1, 86T-->C and gsp exon 5, 81T-->C. Our results indicate that the ras/gsp mutations found are probably late events in the tumorigenesis representing general oncogenic stress. In conclusion, it seems that ras/gsp activation is not a factor in the mechanism causing sporadic thyroid carcinoma in children. Copyright 2001 Wiley-Liss, Inc.

  18. Core-shell PLA-PVA porous microparticles as carriers for bacteriocin nisin.

    Science.gov (United States)

    Holcapkova, Pavlina; Hrabalikova, Martina; Stoplova, Petra; Sedlarik, Vladimir

    2017-05-01

    This work is focused on preparation of novel porous type of core-shell-structured microparticles based on polylactide (shell) and poly(vinyl alcohol) cross-linked with glutaric acid (GA) (core) prepared by water-in-oil-in-water solvent evaporation technique. The microparticle systems were used as delivery systems for immobilisation of model antibacterial agent - nisin. The effect of cross-linking and the initial amount of nisin on their morphology was investigated using scanning electron microscopy, BET analysis, zeta potential measurement and Fourier transform infra-red spectroscopy. Encapsulation efficiency and release profile of nisin from the microparticles were studied by high performance liquid chromatography. Antibacterial activity of the prepared systems was tested by dilution and spread plate technique. Results showed the microparticles in the size range of 9-16 μm in diameter with spherical multi-hollow core-shell structure. The presence of cross-linking agent GA influences the release profile of the peptide and has synergistic effect on Listeria monocytogenes growth reduction.

  19. Descriptive epidemiology of screen and non-screen sedentary time in adolescents: a cross sectional study

    Directory of Open Access Journals (Sweden)

    Ridley Kate

    2010-12-01

    Full Text Available Abstract Background Much attention has been paid to adolescents' screen time, however very few studies have examined non-screen sedentary time (NSST. This study aimed to (1 describe the magnitude and composition of screen sedentary time (SST and NSST in Australian adolescents, (2 describe the socio-demographic correlates of SST and NSST, and (3 determine whether screen time is an adequate surrogate for total sedentary behaviour in this population. Methods 2200 9-16 year old Australians provided detailed use of time data for four days. Non-screen sedentary time (NSST included time spent participating in activities expected to elicit Results Adolescents spent a mean (SD of 345 (105 minutes/day in NSST, which constituted 60% of total sedentary time. School activities contributed 42% of NSST, socialising 19%, self-care (mainly eating 16%, and passive transport 15%. Screen time and NSST showed opposite patterns in relation to key socio-demographic characteristics, including sex, age, weight status, household income, parental education and day type. Because screen time was negatively correlated with NSST (r = -0.58, and exhibited a moderate correlation (r = 0.53 with total sedentary time, screen time was only a moderately effective surrogate for total sedentary time. Conclusions To capture a complete picture of young people's sedentary time, studies should endeavour to measure both screen time and NSST.

  20. The Academic Book of the Future

    Directory of Open Access Journals (Sweden)

    Marilyn Deegan

    2015-11-01

    Full Text Available The Academic Book of the Future is a research project funded by the Arts and Humanities Research Council (AHRC in collaboration with The British Library (BL and is concerned with how scholarly work in the arts and humanities will be produced, read and preserved in coming years. The project is run by a team from University College London (UCL and King’s College London (King’s, with support from the Research Information Network (RIN. The project has built a Community Coalition of more than 100 organizations and individuals.  The project and the Coalition are holding a whole range of events and carrying out research projects on a variety of relevant topics. The key event for 2015 is Academic Book Week, 9-16 November 2015, which has been taken up enthusiastically by the Publishers Association (PA and the Booksellers Association (BA, as well as the Association of Learned and Professional Society Publishers (ALPSP, and was launched in July 2015 with a large announcement in 'The Bookseller. 'Events celebrating the diversity, innovation and influence of academic books will be held across the UK, with participation from institutions elsewhere in Europe and also in the USA, Canada, Japan and Australia.

  1. A new coccidian parasite, Isospora samoaensis, from the Wattled Honeyeater (Foulehaio carunculata) from American Samoa

    Science.gov (United States)

    Adamczyk, Kelly J.; McQuistion, Thomas E.; LaPointe, Dennis

    2004-01-01

    A new species of Isospora is described from the feces of the wattled honeyeater, Foulehaio carunculata from American Samoa. Numerous oocysts of similar morphology were found in a single adult wattled honeyeater. Sporulated oocysts are ovoid, 28.9 × 26.1 (25-32 × 23-30) µm, with a smooth, colorless, bilayered wall; the inner wall is slightly thicker and darker than the outer wall. The average shape index is 1.1. No micropyle or oocyst residuum are present but the oocyst contains one or two ovoid polar granules. Sporocysts are ovoid, 17.1 × 10.9 (16-18 × 10-11) µm with a smooth single layered wall and an average shape index of 1.6. The Stieda body is broad, dome-like with a rather rectangular-shaped substieda body. Within the sporocyst is a large amorphous residuum composed of coarse granules and 4 randomly arranged, sausage-shaped sporozoites with a subspherical, posterior refractile body and a centrally located nucleus.

  2. Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors.

    Science.gov (United States)

    McIver, Andrew L; Zhang, Weihe; Liu, Qingyang; Jiang, Xinpeng; Stashko, Michael A; Nichols, James; Miley, Michael J; Norris-Drouin, Jacqueline; Machius, Mischa; DeRyckere, Deborah; Wood, Edgar; Graham, Douglas K; Earp, H Shelton; Kireev, Dmitri; Frye, Stephen V; Wang, Xiaodong

    2017-02-03

    Macrocycles have attracted significant attention in drug discovery recently. In fact, a few de novo designed macrocyclic kinase inhibitors are currently in clinical trials with good potency and selectivity for their intended target. In this study, we successfully engaged a structure-based drug design approach to discover macrocyclic pyrimidines as potent Mer tyrosine kinase (MerTK)-specific inhibitors. An enzyme-linked immunosorbent assay (ELISA) in 384-well format was employed to evaluate the inhibitory activity of macrocycles in a cell-based assay assessing tyrosine phosphorylation of MerTK. Through structure-activity relationship (SAR) studies, analogue 11 [UNC2541; (S)-7-amino-N-(4-fluorobenzyl)-8-oxo-2,9,16-triaza-1(2,4)-pyrimidinacyclohexadecaphane-1-carboxamide] was identified as a potent and MerTK-specific inhibitor that exhibits sub-micromolar inhibitory activity in the cell-based ELISA. In addition, an X-ray structure of MerTK protein in complex with 11 was resolved to show that these macrocycles bind in the MerTK ATP pocket. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Cognitive domains in the dog: independence of working memory from object learning, selective attention, and motor learning.

    Science.gov (United States)

    Zanghi, Brian M; Araujo, Joseph; Milgram, Norton W

    2015-05-01

    Cognition in dogs, like in humans, is not a unitary process. Some functions, such as simple discrimination learning, are relatively insensitive to age; others, such as visuospatial learning can provide behavioral biomarkers of age. The present experiment sought to further establish the relationship between various cognitive domains, namely visuospatial memory, object discrimination learning (ODL), and selective attention (SA). In addition, we also set up a task to assess motor learning (ML). Thirty-six beagles (9-16 years) performed a variable delay non-matching to position (vDNMP) task using two objects with 20- and 90-s delay and were divided into three groups based on a combined score (HMP = 88-93 % accuracy [N = 12]; MMP = 79-86 % accuracy [N = 12]; LMP = 61-78 % accuracy [N = 12]). Variable object oddity task was used to measure ODL (correct or incorrect object) and SA (0-3 incorrect distractor objects with same [SA-same] or different [SA-diff] correct object as ODL). ML involved reaching various distances (0-15 cm). Age did not differ between memory groups (mean 11.6 years). ODL (ANOVA P = 0.43), or SA-same and SA-different (ANOVA P = 0.96), performance did not differ between the three vDNMP groups, although mean errors during ODL was numerically higher for LMP dogs. Errors increased (P memory performance in aged dogs does not appear to predict performance of cognitive domains associated with object learning, SA, or maximum ML distance.

  4. Risk analysis and technology assessment in support of technology development: Putting responsible innovation in practice in a case study for nanotechnology.

    Science.gov (United States)

    van Wezel, Annemarie P; van Lente, Harro; van de Sandt, Johannes Jm; Bouwmeester, Hans; Vandeberg, Rens Lj; Sips, Adrienne Jam

    2018-01-01

    Governments invest in "key enabling technologies," such as nanotechnology, to solve societal challenges and boost the economy. At the same time, governmental agencies demand risk reduction to prohibit any often unknown adverse effects, and industrial parties demand smart approaches to reduce uncertainties. Responsible research and innovation (RRI) is therefore a central theme in policy making. Risk analysis and technology assessment, together referred to as "RATA," can provide a basis to assess human, environmental, and societal risks of new technological developments during the various stages of technological development. This assessment can help both governmental authorities and innovative industry to move forward in a sustainable manner. Here we describe the developed procedures and products and our experiences to bring RATA in practice within a large Dutch nanotechnology consortium. This is an example of how to put responsible innovation in practice as an integrated part of a research program, how to increase awareness of RATA, and how to help technology developers perform and use RATA. Integr Environ Assess Manag 2018;14:9-16. © 2017 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC). © 2017 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC).

  5. Inhibitory effect of combination of cetuximab and irradiation on colorectal carcinoma CL187 cells

    International Nuclear Information System (INIS)

    Wang Hao; Wang Junjie; Qu Ang; Liu Jingjia; Li Jin'na

    2012-01-01

    Objective: To investigate the combination effect of cetuximab and irradiation on colorectal carcinoma CL187 cell line and underlying molecular mechanism. Methods: CL187 cells with or without cetuximab treatment were irradiated by 0, 4 and 8 Gy X-rays, then cell death percentage was determined by MTT 24 and 48 h post-irradiation. Clone forming assay was used to evaluate the cell reproliferation ability. Cell cycle distribution, apoptosis, and necrosis were analyzed by flow cytometry. Western blot was used to detect the protein expressions of DNA-PKcs, Ku70 and Ku80. Results: The cetuximab enhanced the percentage of radiation-induced cell death, while decreased the cloning formation capacity and increased radiosensitivity (t=-6.14, -6.53, P<0.05). The SER of cetuximab on CL187 cell line approached to 1.38. In addition, cetuximab also increased radiation-induced G 0 /G 1 phase arrest (t=-4.64, P<0.05) and the percentage of apoptosis and necrosis (t=-9.16, P<0.05), but it decreased the expression levels of DNA-PKcs, Ku70 and Ku80 proteins. Conclusions: The cetuximab treatment might enhance the inhibitory effect of irradiation on colorectal carcinoma CL187 cell line by influencing cell cycle distribution, cell apoptosis, and the expression of DNA repair proteins. (authors)

  6. Utility of antigen testing for the diagnosis of ocular histoplasmosis in four cats: a case series and literature review.

    Science.gov (United States)

    Smith, Kathryn M; Strom, Ann R; Gilmour, Margi A; LaDouceur, Elise; Reilly, Christopher M; Byrne, Barbara A; Affolter, Verena K; Sykes, Jane E; Maggs, David J

    2017-10-01

    Case series summary This case series describes the clinical utility of antigen testing for the diagnosis of feline ocular histoplasmosis. Four cats with suspected (n = 2) or confirmed (n = 2) ocular histoplasmosis are described: three from Oklahoma and one from California. In one case, serial urine antigen tests, as well as a serum antigen test for Histoplasma capsulatum, were negative; however, light microscopy identified microorganisms consistent with H capsulatum in ocular tissues at necropsy. In a further two cats with recurrent ocular histoplasmosis following long-term systemic antifungal therapy, Histoplasma species urine antigen concentrations were negative, but both cats improved clinically following systemic antifungal therapy and remained in apparent clinical remission after treatment cessation (9-16 months). The final cat displayed profound bilateral endophthalmitis; however, Histoplasma species antigen testing of vitreous humor and subretinal fluid from the left eye was negative. Intralesional organisms were detected on histopathology of both eyes, and H capsulatum was subsequently isolated and sequenced from tissue of one eye. Relevance and novel information These cases highlight the potential difficulty in definitively diagnosing ocular histoplasmosis in cats when conducting antigen testing of serum, urine and even ocular fluids. Although antigen testing has previously proven useful in the diagnosis of disseminated feline histoplasmosis, it may not be adequate in cats with only ocular signs.

  7. Thalamo-cortical connectivity: what can diffusion tractography tell us about reading difficulties in children?

    Science.gov (United States)

    Fan, Qiuyun; Davis, Nicole; Anderson, Adam W; Cutting, Laurie E

    2014-08-01

    Reading is an essential skill in modern society, but many people have deficits in the decoding and word recognition aspects of reading, a difficulty often referred to as dyslexia. The primary focus of neuroimaging studies to date in dyslexia has been on cortical regions; however, subcortical regions may also be important for explaining this disability. Here, we used diffusion tensor imaging to examine the association between thalamo-cortical connectivity and children's reading ability in 20 children with typically developed reading ability (age range 8-17/10-17 years old from two imaging centers) and 19 children with developmental dyslexia (DYS) (age range 9-17/9-16 years old). To measure thalamo-cortical connections, the structural images were segmented into cortical and subcortical anatomical regions that were used as target and seed regions in the probabilistic tractography analysis. Abnormal thalamic connectivity was found in the dyslexic group in the sensorimotor and lateral prefrontal cortices. These results suggest that the thalamus may play a key role in reading behavior by mediating the functions of task-specific cortical regions; such findings lay the foundation for future studies to investigate further neurobiological anomalies in the development of thalamo-cortical connectivity in DYS.

  8. Sequential endovascular thrombectomy approach (SETA) to acute ischemic stroke: preliminary single-centre results and cost analysis.

    Science.gov (United States)

    Comai, Alessio; Haglmüller, Thomas; Ferro, Federica; Dall'Ora, Elisa; Currò Dossi, Roberto; Bonatti, Giampietro

    2015-07-01

    We report the preliminary results of a single-centre experience in the endovascular treatment (ET) of acute ischemic stroke (AIS) with a sequential endovascular thrombectomy approach (SETA), which comprehends a direct aspiration first-pass technique (ADAPT) eventually followed by stent retriever thrombectomy. We prospectively analyzed data from 16 patients with severe to moderate AIS and CT angiography demonstration of large intracranial vessel occlusion treated with SETA between July 2013 and March 2014. We evaluated recanalization rate, clinical outcome after 90 days as well as differential costs of aspiration and stent-assisted thrombectomy. A group of 16 patients met the eligibility criteria to undergo ET with a baseline NIHSS score of 22 (range 12-39). In 15/16 cases, we obtained target vessel recanalization, 11 cases with ADAPT technique alone. Modified rankin score (mRS) at 90 days follow-up was ≤2 in 9/16 patients (56%). ADAPT technique had a lower device-related cost than stent-assisted thrombectomy leading to an overall saving of -2,747.28 . Our preliminary data suggest that a SETA beginning with direct aspiration could be useful to optimize ET of stroke in terms of invasiveness, safety and cost-effectiveness allowing recanalization with low complication rate.

  9. Association of sports drinks with weight gain among adolescents and young adults.

    Science.gov (United States)

    Field, Alison E; Sonneville, Kendrin R; Falbe, Jennifer; Flint, Alan; Haines, Jess; Rosner, Bernard; Camargo, Carlos A

    2014-10-01

    Sales of regular soda were declining, but sales of other sweetened beverages, such as sports drinks, were increasing. Our objective was to determine the prospective associations between sports drinks and body mass index (BMI) gains among adolescents and young adults. 4121 females and 3438 males in the Growing Up Today Study II, aged 9-16 in 2004, from across the United States were followed prospectively. Data were collected by questionnaire in 2004, 2006, 2008, and 2011. Servings per day of various beverages were assessed with a food frequency questionnaire. Among the girls, each serving per day of sports drink predicted an increase of 0.3 BMI units (95% confidence interval (CI) CI 0.03-0.54) more than their peers over the next 2-3 years. Among the males, each serving of sports drinks predicted a 0.33 BMI (95% CI 0.09, 0.66) increase. In addition, boys who increased their intake over the 2-3 year interval gained significantly more than their peers during the same time interval. Intake of sports drinks predicted larger increases in BMI among both females and males. Our results suggest that school policies focused on obesity prevention should be augmented to restrict sports drinks. Copyright © 2014 The Obesity Society.

  10. Soda-anthraquinone, kraft and organosolv pulping of holm oak trimmings.

    Science.gov (United States)

    Alaejos, J; López, F; Eugenio, M E; Tapias, R

    2006-11-01

    The operating conditions for an organosolv (ethyleneglycol) and two alkaline (soda-anthraquinone and kraft) processes for obtaining cellulose pulp and paper from holm oak (Quercus ilex) wood trimmings were optimized. A range of variation for each process variable (viz. temperature, cooking time and soda or ethyleneglycol concentration) was established and a central composite experimental design involving three independent variables at three different variation levels was applied. The results obtained with the three cooking processes used were compared and those provided by the kraft process were found to be the best. Thus, the tensile index values it provided (5.9-16.3 N m/g) were 23.7% and 41.5% better than those obtained with the soda-AQ and ethyleneglycol processes, respectively. Also, the kraft process provided the best burst index, brightness and kappa number values. Based on the optimum working ranges, the temperature and cooking time were the variables resulting in the most and least marked changes, respectively, in pulp properties.

  11. Role of Chromosome Changes in Evolution and Diversity

    Directory of Open Access Journals (Sweden)

    Kornsorn Srikulnath

    2015-12-01

    Full Text Available The karyotypes of most species of crocodilians were studied using conventional and molecular cytogenetics. These provided an important contribution of chromosomal rearrangements for the evolutionary processes of Crocodylia and Sauropsida (birds and reptiles. The karyotypic features of crocodilians contain small diploid chromosome numbers (30~42, with little interspecific variation of the chromosome arm number (fundamental number among crocodiles (56~60. This suggested that centric fusion and/or fission events occurred in the lineage, leading to crocodilian evolution and diversity. The chromosome numbers of Alligator, Caiman, Melanosuchus, Paleosuchus, Gavialis, Tomistoma, Mecistops, and Osteolaemus were stable within each genus, whereas those of Crocodylus (crocodylians varied within the taxa. This agreed with molecular phylogeny that suggested a highly recent radiation of Crocodylus species. Karyotype analysis also suggests the direction of molecular phylogenetic placement among Crocodylus species and their migration from the Indo-Pacific to Africa and The New World. Crocodylus species originated from an ancestor in the Indo-Pacific around 9~16 million years ago (MYA in the mid-Miocene, with a rapid radiation and dispersion into Africa 8~12 MYA. This was followed by a trans-Atlantic dispersion to the New World between 4~8 MYA in the Pliocene. The chromosomes provided a better understanding of crocodilian evolution and diversity, which will be useful for further study of the genome evolution in Crocodylia.

  12. Family factors and parenting in Ukraine.

    Science.gov (United States)

    Burlaka, Viktor; Graham-Bermann, Sandra A; Delva, Jorge

    2017-10-01

    The present study aimed to estimate the use of positive and negative parenting practices in Ukraine and explore relationships between parenting practices, intimate partner violence (IPV), alcohol use, and sociodemographics. Parents of children (N=320) ages 9-16 from three Ukrainian regions answered questions from the Alabama Parenting Questionnaire (APQ), the Revised Conflict Tactics Scales (CTS-R), Family Adaptability and Cohesion Evaluation Scale (FACES), and the Alcohol Use Section of the Drinking and Drug History and Current Use Patterns questionnaire. Ukrainian parents who reported lower use of alcohol, balanced family functioning and lower intimate partner violence were more likely to use positive parenting and less likely to use negative parenting practices. Parents with lower education were more likely to use negative parenting practices. Furthermore, alcohol use, IPV, parent education and higher family income were significantly and indirectly related with positive and negative parenting scores. The model explained 61% of variance in the positive parenting, 67% in the negative parenting. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Effect of ondansetron on prevention of post-induction hypotension in elderly patients undergoing general anesthesia: A randomized, double-blind placebo-controlled clinical trial.

    Science.gov (United States)

    Golparvar, Mohammad; Saghaei, Mahmoud; Saadati, Mohammad Ali; Farsaei, Shadi

    2015-01-01

    Elderly patients are susceptible to post-induction hypotension. Volume loading and vasopressors for prevention of hypotension in elderly patients may increase perioperative cardiovascular risks. Ondansetron by blocking Bezold-Jarisch reflex (BJR) through inhibition of serotonin receptors has been effective in the prevention of post-spinal hypotension, and bradycardia. Bradycardia frequently accompanies post-induction hypotension in elderly patients, which signifies a possible preventing role for ondansetron. No previous study has evaluated the prophylactic effects of ondansetron for the prevention of post-induction hypotension. In this randomized placebo-controlled clinical trial, ondansetron 4 mg was given intravenously to 65 elderly patients, 20 min before induction of general anesthesia, and the rate of post-induction hypotension defined as 25% or more reduction in mean arterial blood pressure, compared with a placebo groups. A total of 114 patients completed the study (58 in ondansetron and 56 in the placebo group). Proportions of post-induction hypotension were 9 (16%) and 25 (45%) in ondansetron and placebo groups, respectively, (P = 0.001). Forty-five patients (40%) developed bradycardia. Rates of bradycardia were not significantly different between two groups. The results of this study show the effectiveness of intravenous ondansetron for prevention of post-induction hypotension in elderly patients. The mechanism of this effect largely is unknown. Role of ondansetron for prevention of post-induction hypotension may not fully understandable by its interaction with BJR, as has been shown in post-spinal hypotension.

  14. Isolation and characterization of biosurfactant-producing Alcanivorax strains: hydrocarbon accession strategies and alkane hydroxylase gene analysis.

    Science.gov (United States)

    Olivera, Nelda L; Nievas, Marina L; Lozada, Mariana; Del Prado, Guillermo; Dionisi, Hebe M; Siñeriz, Faustino

    2009-01-01

    Biosurfactant-producing bacteria belonging to the genera Alcanivorax, Cobetia and Halomonas were isolated from marine sediments with a history of hydrocarbon exposure (Aristizábal and Gravina Peninsulas, Argentina). Two Alcanivorax isolates were found to form naturally occurring consortia with strains closely related to Pseudomonas putida and Microbacterium esteraromaticum. Alkane hydroxylase gene analysis in these two Alcanivorax strains resulted in the identification of two novel alkB genes, showing 86% and 60% deduced amino acid sequence identity with those of Alcanivorax sp. A-11-3 and Alcanivorax dieselolei P40, respectively. In addition, a gene homologous to alkB2 from Alcanivorax borkumensis was present in one of the strains. The consortium formed by this strain, Alcanivorax sp. PA2 (98.9% 16S rRNA gene sequence identity with A. borkumensis SK2(T)) and P. putida PA1 was characterized in detail. These strains form cell aggregates when growing as mixed culture, though only PA2 was responsible for biosurfactant activity. During exponential growth phase of PA2, cells showed high hydrophobicity and adherence to hydrocarbon droplets. Biosurfactant production was only detectable at late growth and stationary phases, suggesting that it is not involved in initiating oil degradation and that direct interfacial adhesion is the main hydrocarbon accession mode of PA2. This strain could be useful for biotechnological applications due to its biosurfactant production, catabolic and aggregation properties.

  15. In Situ Exsolution of Bimetallic Rh-Ni Nanoalloys: a Highly Efficient Catalyst for CO2Methanation.

    Science.gov (United States)

    Arandiyan, Hamidreza; Wang, Yuan; Scott, Jason; Mesgari, Sara; Dai, Hongxing; Amal, Rose

    2018-03-22

    Unique CO 2 methanation catalysts comprising bimetallic Ni-Rh nanoalloy/3DOM LaAlO 3 have been successfully prepared via a poly(methyl methacrylate) microsphere colloidal crystal-templating route, followed by the in situ growth of Ni nanoparticles (NPs). Here, we show that unlike traditional Ni particles deposited on a perovskite support, the exsolution of Ni occurs on both the external and internal surface of the porous perovskite substrate, leading to a strong metal-support interaction. Owing to the exsolution of Ni and the formation of Ni-Rh nanoalloys, a 52% enhancement in the methanation turnover frequency was obtained over the Ni-Rh/3DOM LaAlO 3 [13.9 mol/(mol h)] compared to Rh/3DOM LaNi 0.08 Al 0.92 O 3 [9.16 mol/(mol h)] before reduction treatment. The results show that the low-temperature reducibility, rich surface adsorbed oxygen species, and basic sites of the catalyst greatly improve its activity toward CO 2 methanation. The hierarchically porous structure of the perovskite support provides a high dispersion of bimetallic Ni-Rh NPs.

  16. Specific alcoholic beverage and blood pressure in a middle-aged Japanese population: the High-risk and Population Strategy for Occupational Health Promotion (HIPOP-OHP) Study.

    Science.gov (United States)

    Okamura, T; Tanaka, T; Yoshita, K; Chiba, N; Takebayashi, T; Kikuchi, Y; Tamaki, J; Tamura, U; Minai, J; Kadowaki, T; Miura, K; Nakagawa, H; Tanihara, S; Okayama, A; Ueshima, H

    2004-01-01

    The purpose of this study was to clarify the effects of popular Japanese alcoholic beverages on blood pressure. We performed a cross-sectional study on 4335 Japanese male workers using baseline data from an intervention study. We defined six groups according to the type of alcoholic beverage that provided two-thirds of the subject's total alcohol consumption: beer, sake (rice wine), shochu (traditional Japanese spirits), whiskey, wine and others. The partial regression coefficients of daily alcohol intake (1 drink=11.5 g of ethanol) to systolic blood pressure (SBP) and diastolic blood pressure (DBP) were 0.87(Pbeer group, this significant relation disappeared after adjusting for the body mass index (BMI), urinary sodium and potassium excretion. The pressor effect, per se, of popular Japanese alcoholic beverages on blood pressure may not be different among the types of alcoholic beverages after adjusting for other lifestyle factors. Journal of Human Hypertension (2004) 18, 9-16. doi:10.1038/sj.jhh.1001627

  17. Effects of titanium nanotubes on the osseointegration, cell differentiation, mineralisation and antibacterial properties of orthopaedic implant surfaces.

    Science.gov (United States)

    Su, E P; Justin, D F; Pratt, C R; Sarin, V K; Nguyen, V S; Oh, S; Jin, S

    2018-01-01

    The development and pre-clinical evaluation of nano-texturised, biomimetic, surfaces of titanium (Ti) implants treated with titanium dioxide (TiO 2 ) nanotube arrays is reviewed. In vitro and in vivo evaluations show that TiO 2 nanotubes on Ti surfaces positively affect the osseointegration, cell differentiation, mineralisation, and anti-microbial properties. This surface treatment can be superimposed onto existing macro and micro porous Ti implants creating a surface texture that also interacts with cells at the nano level. Histology and mechanical pull-out testing of specimens in rabbits indicate that TiO 2 nanotubes improves bone bonding nine-fold (p = 0.008). The rate of mineralisation associated with TiO 2 nanotube surfaces is about three times that of non-treated Ti surfaces. In addition to improved osseointegration properties, TiO 2 nanotubes reduce the initial adhesion and colonisation of Staphylococcus epidermidis Collectively, the properties of Ti implant surfaces enhanced with TiO 2 nanotubes show great promise. Cite this article: Bone Joint J 2018;100-B(1 Supple A):9-16. ©2018 The British Editorial Society of Bone & Joint Surgery.

  18. Baird's beaked whale echolocation signals.

    Science.gov (United States)

    Baumann-Pickering, Simone; Yack, Tina M; Barlow, Jay; Wiggins, Sean M; Hildebrand, John A

    2013-06-01

    Echolocation signals from Baird's beaked whales were recorded during visual and acoustic shipboard surveys of cetaceans in the California Current ecosystem and with autonomous, long-term recorders in the Southern California Bight. The preliminary measurement of the visually validated Baird's beaked whale echolocation signals from towed array data were used as a basis for identifying Baird's signals in the autonomous recorder data. Two distinct signal types were found, one being a beaked whale-like frequency modulated (FM) pulse, the other being a dolphin-like broadband click. The median FM inter-pulse interval was 230 ms. Both signal types showed a consistent multi-peak structure in their spectra with peaks at ~9, 16, 25, and 40 kHz. Depending on signal type, as well as recording aspect and distance to the hydrophone, these peaks varied in relative amplitude. The description of Baird's echolocation signals will allow for studies of their distribution and abundance using towed array data without associated visual sightings and from autonomous seafloor hydrophones.

  19. Three-dimensional cine MRI in free-breathing infants and children with congenital heart disease

    International Nuclear Information System (INIS)

    Seeger, Achim; Fenchel, Michael C.; Kramer, Ulrich; Bretschneider, Christiane; Doering, Joerg; Claussen, Claus D.; Miller, Stephan; Martirosian, Petros; Sieverding, Ludger

    2009-01-01

    Patients with congenital heart disease frequently have complex cardiac and vascular malformations requiring detailed non-invasive diagnostic evaluation including functional parameters. To evaluate the morphological and functional information provided by a novel 3-D cine steady-state free-precession (SSFP) sequence. Twenty consecutive children (mean age 2.2 years, nine boys) were examined using a 1.5-T MR system including 2-D cine gradient-recalled-echo sequences, static 3-D SSFP and 3-D cine SSFP sequences. Measurement of ventricular structures and volumes showed close agreement between the 3-D cine SSFP sequence and the 2-D cine gradient-recalled-echo and static 3-D SSFP sequences (left ventricular volumes mean difference 1.0-1.9 ml and 8.8-11.4%, respectively; right ventricular volumes 1.7-2.1 ml and 9.9-16.9%, respectively). No systematic bias was observed. 3-D cine MRI provides anatomic as well as functional information with sufficient spatial and temporal resolution in free-breathing infants with congenital heart disease. (orig.)

  20. Pengaruh Konsentrasi Minyak Kelapa Murni (Virgin Coconut Oil dan Minyak Jarak (Castor Oil terhadap Sifat Fisikokimia dan Organoleptik Sabun Mandi Cair

    Directory of Open Access Journals (Sweden)

    Asri Widyasanti

    2017-04-01

    Full Text Available VCO contains of lauric acid that perform to smooth and to moisturize the skin. Castor oil has ricinoleic acid that serves to protect the skin. Therefore, both of the oil are suitable to be the raw material for liquid soap making. This study aimed were to produce a liquid soap, to determine the exact concentration of VCO and castor oil for liquid soap and to find out the effect of VCO and Castor Oil concentrations to the characteristics of liquid soap. The method used was laboratory experimental method with descriptive analysis. The treatments in this study were A =concentrations of VCO 100 %, B = concentrations of VCO 80 % and castor oil 20 %, C = concentrations of VCO 50 % and castor oil 50 %, D = concentrations of VCO 20 % and castor oil 80 %, and E = concentrations of castor oil 100 %,  from 200 gram soap base. The parameter observed for liquid soap included chemical properties, physical properties of soap, and organoleptic test. The result shows that all treatments complies the requirement SNI 06-4085-1996. The formula of liquid soap with treatment B was revealed as the best product with 0.01 % of total alkali content, pH value of 9.16 , specific gravity 1.06, and total plate count 5colonies/g. This technology process of natural liquid soap production with the VCO and castor oil could be develop and apply in industrial scale.

  1. Binding affinity and adhesion force of organophosphate hydrolase enzyme with soil particles related to the isoelectric point of the enzyme.

    Science.gov (United States)

    Islam, Shah Md Asraful; Yeasmin, Shabina; Islam, Md Saiful; Islam, Md Shariful

    2017-07-01

    The binding affinity of organophosphate hydrolase enzyme (OphB) with soil particles in relation to the isoelectric point (pI) was studied. Immobilization of OphB with soil particles was observed by confocal microscopy, Fourier transform infrared spectroscopy (FT-IR), and Atomic force microscopy (AFM). The calculated pI of OphB enzyme was increased from 8.69 to 8.89, 9.04 and 9.16 by the single, double and triple mutant of OphB enzyme, respectively through the replacement of negatively charged aspartate with positively charged histidine. Practically, the binding affinity was increased to 5.30%, 11.50%, and 16.80% for single, double and triple mutants, respectively. In contrast, enzyme activity of OphB did not change by the mutation of the enzyme. On the other hand, adhesion forces were gradually increased for wild type OphB enzyme (90 pN) to 96, 100 and 104 pN for single, double and triple mutants of OphB enzyme, respectively. There was an increasing trend of binding affinity and adhesion force by the increase of isoelectric point (pI) of OphB enzyme. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Effects of bisphenol A treatment during pregnancy on kidney development in mice: a stereological and histopathological study.

    Science.gov (United States)

    Nuñez, P; Fernandez, T; García-Arévalo, M; Alonso-Magdalena, P; Nadal, A; Perillan, C; Arguelles, J

    2018-04-01

    Bisphenol A (BPA) is a chemical found in plastics that resembles oestrogen in organisms. Developmental exposure to endocrine-disrupting chemicals, such as BPA, increases the susceptibility to type 2 diabetes (T2DM) and cardiovascular diseases. Animal studies have reported a nephron deficit in offspring exposed to maternal diabetes. The aim of this study was to investigate the prenatal BPA exposure effects on nephrogenesis in a mouse model that was predisposed to T2DM. This study quantitatively evaluated the renal structural changes using stereology and histomorphometry methods. The OF1 pregnant mice were treated with a vehicle or BPA (10 or 100 μg/kg/day) during days 9-16 of gestation (early nephrogenesis). The 30-day-old offspring were sacrificed, and tissue samples were collected and prepared for histopathological and stereology studies. Glomerular abnormalities and reduced glomerular formation were observed in the BPA offspring. The kidneys of the BPA10 and BPA100 female offspring had a significantly lower glomerular number and density than those of the CONTROL female offspring. The glomerular histomorphometry revealed a significant difference between the female and male CONTROL offspring for the analysed glomerular parameters that disappeared in the BPA10 and BPA100 offspring. In addition, the kidney histopathological examination showed typical male cuboidal epithelial cells of the Bowman capsule in the female BPA offspring. Exposure to environmentally relevant doses of BPA during embryonic development altered nephrogenesis. These structural changes could be associated with an increased risk of developing cardiometabolic diseases later in life.

  3. Neutron radiographic detection limits of fluids in metal pipes

    International Nuclear Information System (INIS)

    Winn, W.G.

    1976-01-01

    Routine maintenance of process pipes at the Savannah River Plant has indicated that undesirable fluids can build up in the various gas lines. Thermal neutron radiography has been used to image thin films of various fluids in thick-walled high-pressure process pipes. A 3.5 x 10 6 n/(cm 2 -sec) thermal neutron beam and standard transfer imaging techniques were used to provide radiographs of the fluid-bearing pipes. In addition, a computer graphics procedure was developed that simulated the neutron radiographs; this method permitted examination of some fluid-pipe configurations not studied experimentally. Actual pipe dimensions ranged in OD from 1 / 4 to 9 / 16 in. with OD/ID = 3. Many common industrial fluids such as H 2 O, oils, and CCl 4 may be detected in thick-walled process pipes, even when distributed in thin (3 to 10 mil) fluid films. By contrast, fluids with a low thermal neutron cross section (D 2 O and T 2 O) can be detected only for much thicker films

  4. Subsurface Endospore-Forming Bacteria Possess Bio-Sealant Properties.

    Science.gov (United States)

    Basha, Sreenivasulu; Lingamgunta, Lakshman Kumar; Kannali, Jayakumar; Gajula, Swarna Kumari; Bandikari, Ramesh; Dasari, Sreenivasulu; Dalavai, Veena; Chinthala, Paramageetham; Gundala, Prasada Babu; Kutagolla, Peera; Balaji, Vinodh Kumar

    2018-04-24

    Concrete is a strong and fairly inexpensive building substance, but has several disadvantages like cracking that allows corrosion, thus reducing its lifespan. To mitigate these complications, long-lasting microbial self-healing cement is an alternative that is eco-friendly and also actively repairs cracks. The present paper describes the detailed experimental investigation on compressive strength of cement mortars, mixed with six alkaliphilic bacteria, isolated from subsurface mica mines of high alkalinity. The experiments showed that the addition of alkaliphilic isolates at different cell concentrations (10 4 and 10 6 cells/ml) enhanced the compressive strength of cement mortar, because the rapid growth of bacteria at high alkalinity precipitates calcite crystals that lead to filling of pores and densifying the concrete mix. Thus, Bacillus subtilis (SVUNM4) showed the highest compressive strength (28.61%) of cement mortar at 10 4 cells/ml compared to those of other five alkaliphilic isolates (Brevibacillus sp., SVUNM15-22.1%; P. dendritiformis, SVUNM11-19.9%; B. methylotrophicus, SVUNM9-16%; B. licheniformis, SVUNM14-12.7% and S. maltophilia, SVUNM13-9.6%) and controlled cement mortar as well. This method resulted in the filling of cracks in concrete with calcite (CaCO 3 ), which was observed by scanning electron microscopy (SEM). Our results showed that the alkaliphilic bacterial isolates used in the study are effective in self-healing and repair of concrete cracks.

  5. Sexual function following radical radiotherapy for bladder cancer

    International Nuclear Information System (INIS)

    Little, F.A.; Howard, G.C.W.

    1998-01-01

    Background and purpose: The effect of radical radiotherapy (RT) for bladder cancer on sexual function has not been previously investigated. The current study was designed as a pilot to assess sexual function in males pre- and post-radiotherapy. Materials and methods: An anonymous questionnaire was devised to examine the following sexual domains: libido, frequency of sexual function, erectile capacity, orgasm and ejaculation in the 6 months prior to radiotherapy and following treatment. Serum testosterone, FSH and LH were measured in 10 patients. Results: Eighteen patients completed the questionnaire from 10 to 56 months following irradiation, 13 of whom were able to achieve an erection prior to RT. Over half of these patients noted a decline in the quality of erections after RT, with a similar proportion noting decreased libido and frequency of sexual activity. Three patients lost the ability to have any erections whatsoever. Of the 10 patients retaining erectile capacity, three noted reduced frequency of early morning erections suggesting a physical aetiology, five had decreased frequency of ejaculation and four had reduced intensity of orgasms. Seventy-one percent (12/17) felt their sex life was worse following RT but only 56% (9/16) were concerned about the deterioration. Testosterone levels were normal in all but one patient. Conclusions: Radical RT to the bladder can cause a decrease in sexual function in males. (Copyright (c) 1998 Elsevier Science B.V., Amsterdam. All rights reserved.)

  6. Texcoconibacillus texcoconensis gen. nov., sp. nov., alkalophilic and halotolerant bacteria isolated from soil of the former lake Texcoco (Mexico).

    Science.gov (United States)

    Ruiz-Romero, Erick; Coutiño-Coutiño, María de los Angeles; Valenzuela-Encinas, César; López-Ramírez, María Patricia; Marsch, Rodolfo; Dendooven, Luc

    2013-09-01

    A novel Gram-positive, rod-shaped, spore-forming bacterium, designated 13CC(T) was isolated from soil of the former lake Texcoco. The strain was aerobic, catalase-positive and oxidase-negative. It grew at salinities of 0-26% (w/v) NaCl with an optimum at 9-16% (w/v) NaCl. The cells contain peptidoglycan type A1γ, A1γ' with glycine instead of l-alanine and three variations of peptidoglycan type A4γ. The only quinone detected was MK-7. The major fatty acid was anteiso-C(15:0). The polar lipids fraction consisted of diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine and three different phospholipids. The DNA G+C content was 37.5 mol%. Maximum-likelihood phylogenetic analysis based on 16S rRNA gene sequences revealed that strain 13CC(T) was closely related to members of the genus Bacillus and shared 92.35% similarity with Bacillus agaradhaerens, 92.28% with Bacillus neizhouensis and 92.21% with Bacillus locisalis. It is proposed based on the phenotypic, genotypic and phylogenetic analyses that the novel isolate should be classified as a representative of a new genus and novel species, for which the name Texcoconibacillus texcoconensis gen. nov., sp. nov. is proposed. The type strain of Texcoconibacillus texcoconensis is 13CC(T) ( =JCM 17654(T) =DSM 24696(T)).

  7. Comparison of dorsal and dorsomedial displacement in evaluation of first ray hypermobility in feet with and without hallux valgus.

    Science.gov (United States)

    Singh, Dishan; Biz, Carlo; Corradin, Marco; Favero, Laura

    2016-06-01

    Hypermobility of the first ray, a probable primary cause of hallux valgus, has traditionally been evaluated in the dorsal direction only although the first tarso-metatarsal joint allows movement in a dorso-medial direction. 600 feet, divided according to the presence or absence of hallux valgus, were evaluated for both dorsal and dorso-medial displacement using a Klaue device. In the control group, the mean first ray displacement was 7.2mm (4.2-11.3) in the dorsal direction (sagittal plane) and 8.3mm (4.0-12.6) in the 45° dorso-medial direction. In the hallux valgus group, the mean first ray mobility was 9.8mm (5.2-14.1) in the dorsal direction compared to a mean of 11.0mm (5.9-16.2) in the 45° dorso-medial direction. It is a paradox that hypermobility of the first ray is measured in only a dorsal (vertical) direction whereas a hallux valgus angle and an intermetatarsal angle are only measured in a transverse plane. Furthermore, the weightbearing foot pronates during gait and the first metatarsal is displaced in a dorsomedial direction rather than a pure dorsal direction. It is suggested that measurement hypermobility of the first ray at a 45° dorso-medial direction is more appropriate. Copyright © 2015 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.

  8. Asymptomatic carotid artery stenosis in patients with severe peripheral vascular diseases

    Directory of Open Access Journals (Sweden)

    Rasoul Mirsharifi

    2009-04-01

    Full Text Available

    • BACKGROUND: The prevalence of carotid artery stenosis (CAS in the  eneral population is not high enough to justify screening programs. This study was done to determine the prevalence of asymptomatic carotid artery stenosis (ACAS among patients with severe peripheral vascular disease (PVD.
    • METHODS: Between March 2005 and February 2006, 54 consecutive  atients with severe PVD admitted at a vascular surgery unit and underwent carotid duplex scanning in a prospective study. A  uestionnaire was used to collect data concerning known risk factors. Significant CAS was defined as a stenosis of 70% or greater.
    • RESULTS: The mean age was 62.5 years (51-72. Out of 54 patients, 2 (3.7% had an occluded internal carotid artery. Significant CAS was found in 9 (16.7% and its presence was correlated with diabetes, hypertension, hypercholesterolemia, hypertriglyceridemia, coronary artery disease, severity of symptoms, ankle-brachial index, and carotid bruit. On multivariate analysis, only hypercholesterolemia and carotid bruit seemed to have independent influence.
    • CONCLUSION: The prevalence of significant ACAS is higher among  atients with severe PVD. This patient population may indicate a  uitable subgroup for screening of ACAS, especially when hypercholesterolemia and carotid bruit are present.
    • KEYWORDS: Carotid artery stenosis, duplex ultrasound scanning, peripheral vascular disease, carotid endarterectomy,
    • cerebrovascular accident.

  9. Avaliação da Atividade Alimentar dos Invertebrados de Solo em Campos do Sul do Brasil – Bait-Lamina Test

    Directory of Open Access Journals (Sweden)

    Luciana Podgaiski

    2011-11-01

    Abstract. The aim of this work is to inform about a pioneer bait-lamina test in the South Brazilian Campos to evaluate the soil invertebrates feeding activity which is an approaching to leaf litter decomposition rates in the ecosystems. The feeding activity was tested during two months, across 8 cm of soil depth and employing a comparison between two techniques of consumption quantification (conservative technique vs. practical technique in two different grassland areas (grazed and not grazed were described. One hundred independent sampling units (s.u. were established on each area, and in each s.u. two bait-lamina were inserted: one horizontally and another vertically. For each sampling date (9, 16, 22, 29 e 65 days of exposition, 20 s.u. were sorted and analyzed. We observed a high feeding activity from the beginning of the experiments, both in the surface and within the soil. Soil fauna feeding activity differed according to soil depth, being higher on the surface and for 6.5-8 cm deep in the soil. Both techniques lead to similar results when the two areas were compared. The grazed site showed lower invertebrate feeding activity than the site not grazed. These findings constitute a basis for future researches in Brazil, relating that the bait-lamina test can offer useful results around fifteen days of exposition.

  10. Yoga Practice Increases Minimum Muscular Fitness in Children with Visual Impairment.

    Science.gov (United States)

    Mohanty, Soubhagyalaxmi; Venkata Ramana Murty, Peri; Pradhan, Balaram; Hankey, Alex

    2015-12-01

    Muscle strength, a component for balance, gait and functional mobility is vital for children with visual impairment. Yoga has frequently been demonstrated to improve physical and mental fitness in children. This study aimed to assess the effect of 16 weeks yoga training on muscular fitness in children with visual impairment. This was a wait-listed two-armed-matched case-control study. Eighty (41 yoga, 39 control) visual impairment students of both genders aged 9-16 years matched on age, gender and degree of blindness were assessed at pre, mid (after 8 weeks) and post (after 16 weeks) yoga intervention using the Kraus-Weber test. The percentage of students passed in yoga group were 12.2%, 43.9% and 68.3% whereas percentages in the control group were 23.1%, 30.8% and 30.8% in pre, mid, and post tests respectively. McNemar test showed significant differences between pre and mid, mid and post in the yoga group while those parameters were not significantly different in the control group. Yoga therapy seemed to have considerable benefits for the children's muscular fitness. The study suggests that yoga have considerable benefits for improvement of fitness level in children with visual impairment and may be recommended as and effective, alternative, inexpensive low risk training activity option for them.

  11. Macrosomic Neonates Carry Increased Risk of Dental Caries in Early Childhood: Findings from a Cohort Study, the Okinawa Child Health Study, Japan.

    Directory of Open Access Journals (Sweden)

    Hiroshi Yokomichi

    Full Text Available Although many studies have discussed health risks in neonates with a low birth weight, few studies have focused on the risks in neonates with a high birth weight. The objective of this study was to determine whether differences in the incidence of dental caries in early childhood are associated with birth weight status.A total of 117,175 children born in Okinawa Prefecture, Japan from 1997 to 2007 were included in this study. Medical professionals collected information about birth records, growth and development, parental child-rearing practices and dental health at 3 months, 18 months and 3 years of age. The risk of dental caries among neonates with macrosomia (birth weight ≥4000 g was compared with that among neonates with normal weight (2500-3999 g. Sensitivity analyses included 'large for gestational age' (LGA, birth weight above the 90th percentile for gestational age, which was relative to 'appropriate for gestational age' (birth weight between 10th and 90th percentiles. Relative risks and relative risk increases were estimated by multivariate Poisson regression.At 3 years of age, the relative risk increases for dental caries after adjusting for confounding factors were 19% [95% confidence interval (CI, 11%-28%, P < 0.001] for macrosomic neonates and 12% (95% CI, 9%-16%, P < 0.001 for LGA neonates.Macrosomia and LGA were associated with an increased risk of dental caries in early childhood. Particular attention should be paid to abnormally large neonates.

  12. Response time scores on a reflexive attention task predict a child's inattention score from a parent report.

    Science.gov (United States)

    Lundwall, Rebecca A; Sgro, Jordan F; Fanger, Julia

    2018-01-01

    Compared to sustained attention, only a small proportion of studies examine reflexive attention as a component of everyday attention. Understanding the significance of reflexive attention to everyday attention may inform better treatments for attentional disorders. Children from a general population (recruited when they were from 9-16 years old) completed an exogenously-cued task measuring the extent to which attention is captured by peripheral cue-target conditions. Parents completed a questionnaire reporting their child's day-to-day attention. A general linear model indicated that parent-rated inattention predicted the increase in response time over baseline when a bright cue preceded the target (whether it was valid or invalid) but not when a dim cue preceded the target. More attentive children had more pronounced response time increases from baseline. Our findings suggest a link between a basic measure of cognition (response time difference scores) and parent observations. The findings have implications for increased understanding of the role of reflexive attention in the everyday attention of children.

  13. Vibrational branching ratios and radiative lifetimes in the laser cooling of AlBr.

    Science.gov (United States)

    Gao, Yufeng; Wan, Mingjie

    2017-02-15

    The feasibility of laser cooling of the AlBr molecule is investigated using ab initio quantum chemistry. Potential energy curves, permanent dipole moments, and transition dipole moments for the ground state X 1 Σ + and the first two excited states (a 3 Π and A 1 Π) are calculated using the multi-reference configuration interaction plus Davidson corrections (MRCI+Q) method with the ACVQZ basis set; the spin-orbit coupling effects are also taken into account in electronic structure calculations at the MRCI level. Based on the acquired potential energy curves and transition dipole moments, highly diagonally distributed Franck-Condon factors (f 00 = 0.9540, f 11 = 0.8172) and vibrational branching ratios (R 00 = 0.9708, R 11 = 0.8420) for the transition are determined. Radiative lifetime calculations of the A 1 Π 1 (ν' = 0-4) state are found to be short (9.16-11.48 ns) enough for rapid laser cooling. The proposed main cycling laser drives the transition at the wavelength λ 00 = 279.19 nm. The vibrational branching loss ratios of the A 1 Π 1 (ν') state to the intervening states a 3 Π 0 + and a 3 Π 1 are small (laser cooling.

  14. Testing for thrombophilia in mesenteric venous thrombosis - Retrospective original study and systematic review.

    Science.gov (United States)

    Zarrouk, M; Salim, S; Elf, J; Gottsäter, A; Acosta, S

    2017-02-01

    The aim was to perform a local study of risk factors and thrombophilia in mesenteric venous thrombosis (MVT), and to review the literature concerning thrombophilia testing in MVT. Patients hospitalized for surgical or medical treatment of MVT at our center 2000-2015. A systematic review of observational studies was performed. In the local study, the most frequently identified risk factor was Factor V Leiden mutation. The systematic review included 14 original studies. The highest pooled percentage of any inherited thrombophilic factor were: Factor V Leiden mutation 9% (CI 2.9-16.1), prothrombin gene mutation 7% (CI 2.7-11.8). The highest pooled percentage of acquired thrombophilic factors were JAK2 V617F mutation 14% (CI -1.9-28.1). The wide range of frequency of inherited and acquired thrombophilic factors in different populations indicates the necessity to relate these factors to background population based data in order to estimate their overrepresentation in MVT. There is a need to develop guidelines for when and how thrombophilia testing should be performed in MVT. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. ATRAZINE ADSORPTION-DESORPTION BEHAVIOR IN DAREHASALUIE KAVAR CORN FIELD SOIL

    Directory of Open Access Journals (Sweden)

    M. Dehghani, S. Nasseri, S. Amin, K. Naddafi, M. Yunesian, M. Taghavi and N. Maleki

    2005-10-01

    Full Text Available Adsorption desorption behaviors of widely applied atrazine soil were studied, employing a batch technique as a case study in Darehasaluie Kavar corn field in Fars Province in 2005. Samples were collected into 0 to 20 cm soil depth, where was cultivated under a crop rotation (corn-wheat during the past 10 years. Sorption kinetics exhibited two phenomena: an immediate rapid sorption (1.31 µg/g soil after 12 hours followed by a slow sorption process (1.37 µg/g soil after 24 hours. Desorption behavior of atrazine was similar to its adsorption, but at a very slower rate. Atrazine desorption efficiencies were much less effective and incomplete even after a long equilibration time (only 9.16% after 96 hours. The adsorption-desorption rate for most of the time was positively related to the amount of applied atrazine and the time required for equilibration (P<0.01. Desorption data exhibited hysteresis phenomena. Atrazine adsorption data described well according to Freundlich (r2=0.95, Langmuir (r2=0.82 and Temkin (r2=0.84 isotherms. However, the fit to Freundlich adsorption model in a non linear form (1/n <1 was closer than the others. Desorption isotherm could be well described by the Temkin (r2=0.96 and Freundlich (r2=0.92 isotherms, but the fit to Temkin model was closer than that of Freundlich.

  16. Combined effect of organic manure and potassium on growth and yield of onion cv. BARI piaz-I

    Directory of Open Access Journals (Sweden)

    H.K. Barman

    2013-06-01

    Full Text Available An experiment was conducted to find out the combined effect of cowdung and potassium on the growth and yield of onion cv. BARI piaz-I at Horticulture Farm, Bangladesh Agricultural University, Mymensingh during the period from December 2010 to March 2011. The experiment was laid out in a randomized complete block design with three replications. The two factors experiment had four levels of cowdung, viz., 0, 5, 10 and 20 tons ha-1 and four levels of potassium, viz. 0, 50, 150 and 250 kg K ha-1. Doses of cowdung and potassium showed significant variation in respect of all the parameters studied. The combination of 10 tons cowdung and 250 kg K ha-1 gave the tallest plant (46.60 cm, the highest number of leaves plant-1 (6.40, the highest length of bulb (3.27 cm, the highest diameter of bulb (4.83 cm, individual weight of bulb (51.23 g, dry matter content (12.66% and yield of bulb ha-1 (12.83 tons; whereas the control treatment gave the shortest plant (38.15 cm, lowest number of leaves plant-1 (5.68, diameter of bulb (3.41, individual weight of bulb (35.65g and gave lowest bulb yield ha-1 (9.16 tons.

  17. Analysis of some components of resistance in the hybrids of banana FHIA-23 and plantain FHIA-21 to black (Mycosphaerella fijiensis Morelet) and yellow (M. musicola Leach) sigatokas

    International Nuclear Information System (INIS)

    Guzman Piedrahita, Oscar Adrian; Castano Zapata, Jairo

    2009-01-01

    It was determined the performance of FHIA-20 and FHIA-23 to both Mycosphaerella fijiensis and M. musicola. The study was conducted in a screen house at the Montelindos farm of the University of Caldas, at 1010 most, average temperature 22.8 Celsius degrade, annual precipitation 2200 mm, and relative humidity 76%. Conidia of Paracercospora fijiensis and Pseudocercospora musae, and mixture of both, were inoculated to seedlings having between 4 and 6 leaves. It was evaluated incubation period (IP) of both pathogens, times of evolution of symptoms (TES) and disease development (TDD), also, lesions per leaf (NLL). In FHIA-20, P. musae, P. fijiensis and P. musae+P. fijiensis, had a longer IP than in Dominico Harton, being 3, 20 and 10 days longer, respectively; in addition, the TES of yellow and black sigatokas and the combination of both diseases, was more prolonged in FHIA-20, in 5, 49 and 26 days, respectively, than in local material. In FHIA-23, P. musae, P. fijiensis and P. musae + P. fijiensis, had 2, 6 and 3 more days of IP, respectively, than in Gros Michel; furthermore, FHIA-23 had a TES of yellow and black sigatokas and the combination of both, higher than in Gros Michel, in 9, 16 and 11 days, respectively. In general, FHIA-23 behaved as highly resistant and tolerant to black and yellow sigatokas, respectively, and FHIA-23, resistant.

  18. Comparison of lipid lowering effect of extra virgin olive oil and atorvastatin in dyslipidemia in type 2 diabetes mellitus

    International Nuclear Information System (INIS)

    Khan, T.M.

    2017-01-01

    Extra virgin olive oil (EVOO) is fruit oil with rich source of monounsaturated fats and powerful antioxidants. It acts as hypolipidemic agent and significant decrease of plasma lipids levelwas observed with EVOO use. Atorvastatin is hypolipidemic drug commonly used for treatment of hyperlipidaemia. The purpose of this study was to determine and compare the lipid lowering effect of EVOO with atorvastatin in type 2 diabetic dyslipidaemia which is leading cause of microvascular diseases. Methods: This cross-sectional study was conducted on 60 already diagnosed cases of type 2 diabetes mellitus with dyslipidaemia. All sixty subjects were divided into 2 groups. Atorvastatin 40mg was given to Group One and two tablespoons of extra virgin olive oil orally per day was given to Group Two. Blood was collected for estimation of plasma lipids level at base line, 4th week, and 6th weeks in two groups and was compared statistically. Results: The present study demonstrated 20-40% lipid lowering effect of atorvastatin on plasma lipids level with 9-16% increase in HDL while extra virgin olive oil showed 14 to 25% reduction in plasma lipids with 8-12% increase in HDL-cholesterol level. Conclusion: This study concludes that both atorvastatin and extra virgin olive oil are effective in reducing plasma lipids level in type 2 diabetic dyslipidaemia with more prominent effect of atorvastatin than EVOO. (author)

  19. Machine Learning Based Online Performance Prediction for Runtime Parallelization and Task Scheduling

    Energy Technology Data Exchange (ETDEWEB)

    Li, J; Ma, X; Singh, K; Schulz, M; de Supinski, B R; McKee, S A

    2008-10-09

    With the emerging many-core paradigm, parallel programming must extend beyond its traditional realm of scientific applications. Converting existing sequential applications as well as developing next-generation software requires assistance from hardware, compilers and runtime systems to exploit parallelism transparently within applications. These systems must decompose applications into tasks that can be executed in parallel and then schedule those tasks to minimize load imbalance. However, many systems lack a priori knowledge about the execution time of all tasks to perform effective load balancing with low scheduling overhead. In this paper, we approach this fundamental problem using machine learning techniques first to generate performance models for all tasks and then applying those models to perform automatic performance prediction across program executions. We also extend an existing scheduling algorithm to use generated task cost estimates for online task partitioning and scheduling. We implement the above techniques in the pR framework, which transparently parallelizes scripts in the popular R language, and evaluate their performance and overhead with both a real-world application and a large number of synthetic representative test scripts. Our experimental results show that our proposed approach significantly improves task partitioning and scheduling, with maximum improvements of 21.8%, 40.3% and 22.1% and average improvements of 15.9%, 16.9% and 4.2% for LMM (a real R application) and synthetic test cases with independent and dependent tasks, respectively.

  20. A sclerotic rim provides mechanical support for the femoral head in osteonecrosis.

    Science.gov (United States)

    Yu, Tong; Xie, Limin; Chu, Fulei

    2015-05-01

    Osteonecrotic collapse of the femoral head is a common refractory disease in orthopedics, and the occurrence of collapse is an important factor in the prognosis of this condition. Osteonecrotic collapse of the femoral head can be delayed or prevented by the formation of a sclerotic rim. This study used finite element analysis to evaluate the mechanical role of a proximal sclerotic rim on stress on the femoral head. The study used a healthy man who underwent computed tomography of both hips to generate 3-dimensional finite element models with different proportions of proximal rim sclerosis (0%, 30%, 50%, and 100%). Using a negative directional mechanical load of 400 N along the Z-axis, total deformation, deformation in the negative Z-axial direction (ie, direction of longitudinal compression), maximum principal stress, minimum principal stress, and contact pressure on necrotic tissue were evaluated. For 0%, 30%, 50%, and 100% rim sclerosis, total femoral head deformation was 0.21, 0.205, 0.20, and 0.19 mm, respectively, and maximum principal stress in compression was 9.83, 9.67, 9.16, and 9.05 MPa, respectively. Increases in proximal rim sclerosis decreased all of the measured outcomes. These results suggest that proximal rim sclerosis provides effective mechanical support for the femoral head, offers mechanical protection for necrotic tissue, decreases deformation of the femoral head, and delays or prevents collapse in osteonecrosis. Copyright 2015, SLACK Incorporated.

  1. The optimization of propagation medium for the increase of laccase production by the white-rot fungus Pleurotus ostreatus

    Directory of Open Access Journals (Sweden)

    Hazuchová Miroslava

    2017-12-01

    Full Text Available The lignocellulolytic enzymes are routinely produced by submerged fermentation using lignocellulosic material, but for more effective production, it would be suitable to precede the production phase on the lignocellulose by propagation phase in the nutrition medium suitable for growth of the fungi. Therefore, the aim of this study was to increase the laccase production by the white-rot fungus Pleurotus ostreatus by two-step cultivation strategy. In the first step, propagation medium was optimized for the maximal biomass growth, the second step included the laccase production by produced fungal biomass in media with the selected lignocellulosic material (pine sawdust, alfalfa steam and corn straw. From our experiments, parameters such as glucose concentration, yeast extract concentration and pH of propagation medium were selected as key factors affecting growth of P. ostreatus. The optimal conditions of propagation medium for maximal fungal growth determined by response surface methodology were: glucose concentration 102.68 g/L, yeast extract concentration 43.65 g/L and pH of propagation medium 7.24. These values were experimentally verified and used statistical model of biomass production prediction was appropriate adjusted. Thus prepared fungal biomass produced in the media with lignocellulose approximately 9-16 times higher concentrations of the laccase in 3 times shorter time than the fungal biomass without propagation phase in optimized propagation medium.

  2. Genetic verification and chemical contents identification of Allamanda species (Apocynaceae).

    Science.gov (United States)

    Chaveerach, Arunrat; Aungkapattamagul, Sarocha; Tanee, Tawatchai; Noikotr, Kowit; Sudmoon, Runglawan

    2014-05-01

    Allamanda species (Apocynaceae) are popular ornamentals. Additionally, A. cathartica possesses medicinal properties whereas all other species have not been reported. This research aims to analyze genetics and chemical contents of Allamanda species existing in Thailand. The explored species are A. blanchetii, A. cathartica, A. neriifolia, A. schottii, and A. violacea. The dendrogram constructed from 16 inter-simple sequence repeat markers clearly distinguished species with genetic similarity values of 0.92-0.93 for species level and 0.50-0.76 for genus level. Diverse chemicals content in hexane extracts from A. blanchetii, A. neriifolia, A. schottii, and A. violacea were detected by gas chromatography-mass spectrometry. A high amount of squalene was found in A. blanchetii (55.81%) and A. violacea (51.09%). This content may function as a chemo preventative substance to protect people from cancer. α-Tocopherol, a form of vitamin E, was one of the predominant components found in A. violacea (26.325%), A. schottii (15.41%), and A. neriifolia (9.16%). One more substance, 9,12,15-octadecatrien-1-ol, was found to be relatively high in A. schottii (17.31%) and A. neriifolia (15.51%). Other minor and unknown compounds were also detected. The discovery of these chemicals provides an alternative and supplement for improving human well-being and pharmaceutical industries with natural resources, especially in light of the population increase.

  3. Evaluation of cardiac functions in patients with thalassemia major

    Energy Technology Data Exchange (ETDEWEB)

    Kucuk, N.O.; Aras, G.; Sipahi, T.; Ibis, E.; Akar, N.; Soylu, A.; Erbay, G. [Ankara Univ. (Turkey). Medical School

    1999-06-01

    It is known that a blood transfusion is necessary for survival in patients with thalassemia, but it may cause myocardial dysfunction due to myocardial siderosis as in other organs. The aim of this study was to evaluate myocardial perfusion by means of stress thallium scanning (MPS) and left ventricular functions by rest radionuclide ventriculography (RNV). Twenty-one patients at ages 9-16 (mean 12.1{+-}3.2) who have been diagnosed with thalassemia for 4-15 years mean 12.7{+-}4.8) were included in the study. They had blood transfusion 78-318 times (mean 162.1{+-}71). MPS and RNV was performed within two days after the any transfusion. MPS showed ischemia in 3 patients and normal perfusion in 18 patients. RNV revealed normal systolic parameters (wall motion, EF, PER, TPE) but diminished diastolic parameters (TPF, PFR) compared with normal values (p<0.05). We conclude that ischemia or fixed defects may be seen in stress MPS as results of cardiac involvement in patients with thalassemia. But, RNV is an important and preferable test for the early detection of subclinic cardiomyopathy. RNV may therefore show diastolic abnormalities before the systolic abnormalities show up. (author)

  4. Prospective cohort study with active surveillance for fever in four dengue endemic countries in Latin America.

    Science.gov (United States)

    Dayan, Gustavo; Arredondo, Jose L; Carrasquilla, Gabriel; Deseda, Carmen C; Dietze, Reynaldo; Luz, Kleber; Costa, Maria Selma N; Cunha, Rivaldo V; Rey, Luis C; Morales, Javier; Reynales, Humberto; Miranda, Maria; Zambrano, Betzana; Rivas, Enrique; Garbes, Pedro; Noriega, Fernando

    2015-07-01

    To prepare for a Phase III dengue vaccine efficacy trial, 20 investigational sites were selected for this observational study to identify dengue infections in a closed cohort (N = 3,000 children 9-16 years of age). Of 255 acute febrile episodes experienced by 235 children, 50 (21.3%) were considered serologically probable dengue, and 18 (7.7%) were considered virologically confirmed (i.e., dengue NS1 antigen positive) dengue cases. Considering the disease-free and at-risk period from study start to onset of symptoms, the overall incidence density of acute febrile episodes was 17.7 per 100 person-years of follow-up, ranging from 15.3 in Colombia to 22.0 in Puerto Rico. This study showed that all sites were capable of capturing and following up acute febrile episodes within a specific timeframe among the established cohort and to detect dengue cases. © The American Society of Tropical Medicine and Hygiene.

  5. [Clinicopathological analysis of 23 cases of NK/T-cell lymphoma of nasal type].

    Science.gov (United States)

    Lu, Mingshen; Li, Fancai; Hou, Qiaoyan

    2009-01-01

    To improve the understanding of nasal NK/T-cell lymphoma by analyzing its phenotypic and clinicopathological features. Twenty-three cases of nasal NK/T-cell lymphoma diagnosed between 2003 and 2007 in the department of pathology of Guilin Medical College were included in the study. The expression level of TIA-1, CD56, CD3, CD20, CK and EBV markers was determined by immunohistochemistry. The results were correlated with clinicopathological features. 69.9% (16/23) of the nasal NK/T-cell lymphoma occurred in the nasal cavity. All the 23 cases displayed necrosis, ulceration and nose bleeding. 39.1% (9/23) showed angiodestructive growth pattern. 21.74% (5/23) were accompanied by squamous cell carcinoma-like epitheliomatous hyperplasia. All the cases were positive for TIA-1 and CD3. 95.7% (22/23) of the cases were positive for CD56, while 21.7% (5/23) were weakly positive for EBV. None of the cases was positive for either CD20 or CK. Nasal NK/T-cell lymphoma is characterized by multiple clinicopathological features. Attention is needed to differentiate the tumor from inflammatory lesions and low grade squamous cell carcinoma. Understanding of various morphological and phenotypic features (i.e. expression of TIA-1, CD56 and CD3, and lack of CD20 and CK) is the key for the diagnosis of nasal NK/T-cell lymphoma.

  6. Spinning wave plate design for retinal birefringence scanning

    Science.gov (United States)

    Irsch, K.; Gramatikov, B. I.; Wu, Y.-K.; Guyton, D. L.

    2009-02-01

    To enhance foveal fixation detection while bypassing the deleterious effects of corneal birefringence in retinal birefringence scanning (RBS), we developed a new RBS design introducing a double-pass spinning half wave plate (HWP) and a fixed double-pass retarder into the optical system. Utilizing the measured corneal birefringence from a data set of 300 human eyes, an algorithm and a related computer program, based on Mueller-Stokes matrix calculus, were developed in MATLAB for optimizing the properties of both wave plates. Foveal fixation detection was optimized with the HWP spun 9/16 as fast as the circular scan, with the fixed retarder having a retardance of 45° and fast axis at 90°. With this new RBS design, a significant statistical improvement of 7.3 times in signal strength, i.e. FFT power, was achieved for the available data set compared with the previous RBS design. The computer-model-optimized RBS design has the potential not only for eye alignment screening, but also for remote fixation sensing and eye tracking applications.

  7. Lexical tonal discrimination in Zapotec children. A study of the theta rhythm.

    Science.gov (United States)

    Poblano, Adrián; Castro-Sierra, Eduardo; Arteaga, Carmina; Pérez-Ruiz, Santiago J

    Zapotec is a language used mainly in the state of Oaxaca in Mexico of tonal characteristic; homophone words with difference in fundamental frequency with different meanings. Our objective was to analyze changes in the electroencephalographic (EEG) theta rhythm during word discrimination of lexical tonal bi-syllabic homophone word samples of Zapotec. We employed electroencephalography analysis during lexical tonal discrimination in 12 healthy subjects 9-16 years of age. We observed an increase in theta relative power between lexical discrimination and at rest eyes-open state in right temporal site. We also observed several significant intra- and inter-hemispheric correlations in several scalp sites, mainly in left fronto-temporal and right temporal areas when subjects were performing lexical discrimination. Our data suggest more engagement of neural networks of the right hemisphere are involved in Zapotec language discrimination. Copyright © 2015 Hospital Infantil de México Federico Gómez. Publicado por Masson Doyma México S.A. All rights reserved.

  8. Retinal Injury Secondary to Laser Pointers in Pediatric Patients.

    Science.gov (United States)

    Xu, Kunyong; Chin, Eric K; Quiram, Polly A; Davies, John B; Parke, D Wilkin; Almeida, David R P

    2016-10-01

    This case report describes 4 male children (age, 9-16) who had laser-related retinal injury to the macula of 1 eye or both eyes due to the mishandling of the laser pointer devices at a single vitreoretinal clinical practice. The presenting symptoms associated with laser pointer injury include central vision loss, central scotoma, and metamorphopsia. Clinical findings of laser-related retinal injury include reduced visual acuity, disruption of the photoreceptor ellipsoid zone, retinal pigment epithelium atrophy, and choroidal neovascular membrane formation. Disruption of the foveal ellipsoid zone (photoreceptor inner segment/outer segment layer) is the most common finding on optical coherence tomography imaging. Three patients had potential irreversible vision loss. Laser pointers are readily available and appropriate use of laser pointers in the pediatric population must be emphasized due to the potential irreversible retinal injury. Health professionals, school teachers, and parents should raise public awareness of this emerging public health issue by educating children about the dangers of laser pointers. Laser pointer devices among children should be discouraged and limited due to the possibility of permanent harm to themselves and others. Legislation and laws may be required to better control the sale and use of these devices. Copyright © 2016 by the American Academy of Pediatrics.

  9. Evaluation of the comparative growth and reproductive performance of West African dwarf goats in the western highlands of Cameroon

    International Nuclear Information System (INIS)

    Tedonkeng Pamo, E.; Tendonkeng, F.; Kadjio, J.T.T.; Kwami, H.N.; Taboum, R.K.; Kana, J.R.; Tegodjeu, A.

    2002-01-01

    On-farm and on-station evaluations of the comparative growth performance of West African Dwarf Goats supplemented at an iso-nitrogenous level (6 g/animal/day) with leguminous browse Calliandra calothyrsus, Leucaena leucocephala, or Gliricidia sepium, or with cotton seed cake, were conducted around Dschang in the Western Highlands of Cameroon and at the University Experimental Farm. The animals were weighed every 21 days during the rainy season and every 14 days during the dry season for three months to evaluate their response to supplementation. Cotton seed cake, L. leucocephala, C. calothyrsus were the most accepted supplements. The weight gain of the animals fed with these supplements was significantly higher compared to that of the control animals. Mean weight of animals supplemented with G. sepium was not significantly different (P>0.05) from that of the control group during the rainy season. The average daily weight gains during the rainy period were 20.6, 19.1, 13.8, 4.5, and 3.1 g for L. leucocephala, cotton seed cake, C. calothyrsus, G. sepium and the control animals respectively, during the rainy season and 19.9, 16.1 and 1.7 g for cotton seed cake, L. leucocephala and the control animal respectively, during the dry season. Progesterone profiles were low and were unaffected by supplementation during the dry season. (author)

  10. The efficiency of sonography in diagnosing volvulus in neonates with suspected intestinal malrotation.

    Science.gov (United States)

    Zhang, Wenhua; Sun, Hongjun; Luo, Fangqiong

    2017-10-01

    This study is to prospectively evaluate the efficiency of sonography for volvulus diagnosis in neonates with clinically suspected intestinal malrotation.A total of 83 patients with suspected intestinal malrotation who underwent detailed abdominal sonography and upper gastrointestinal contrast study were included. Malrotation was characterized by inversion of the superior mesenteric artery (SMA) and superior mesenteric vein (SMV) in sonographic examination. The "whirlpool sign" of Color Doppler Sonography was recognized as a characteristic for malrotation with volvulus. The degrees of rotation of the SMV winding around SMA were also detected by sonography. Surgery was performed in patients with sonography diagnosed malrotation.A total of 39 patients were sonographically diagnosed as malrotation which was subsequently confirmed by surgery. The sensitivity and positive predictive value of the sonographic diagnosis were both 100% (39/39). The sensitivity, specificity and accuracy of "whirlpool sign" for the detection of midgut volvulus were 95.2% (20/21), 88.9% (16/18), and 92.3% (36/39), respectively. Greater degrees of rotation (equal or greater than 720°) showed higher risk (odds ratio, 5.0; P intestinal necrosis occurrence.Sonography is more accurate in diagnosing suspected malrotation than upper gastrointestinal contrast study. Specific sonographic "whirlpool sign" related to volvulus may be used as a potential indicator for intestinal necrosis. In addition, sonography can exclude malrotation and may help the diagnosis of other diseases, such as annular pancreas and duodenal atresia.

  11. Evaluation of the causes of the exams repetition in a mammography service

    International Nuclear Information System (INIS)

    Padilha Filho, L.G.; Pereira, W.W.; Montone Junior, V.; Beskow, R.LK.; Berquo, F.R.; Chernicharo, C.C.; Lins, R.P.N.; Petrelli, A. dos S.C.; Santos, R.P.

    2001-01-01

    The objective of this work is to evaluate and become clear the causes of repetitions of the mammography centre of the Santa Casa da Misericordia do Rio de Janeiro (CDM/SCMRJ). This will become possible to make the necessary modifications to a better learning to the residents of CDM/SCMRJ and also to the students of medical physics of Fundacao Tecnico Educacional Souza Marques. During the period of 2001 April to 2001 July, 131 rejections from a total of 3936 mammography's exams over patients from CDM/SCMRJ, taking in consideration, the mistakes over confection of mammography. The obtained results show in a preliminary evaluation that from 131 utilized films, the more frequent mistakes were 29% from the positioning; 16.79% from radiographic artifacts; 9.16% from sub-exposition; 8.39% from inadequate techniques; 8.39% from overcast. The majority of rejected films happened during a clinical phase of radiographic confection, this shows that the efforts that have been done in the teaching and training from technicians and residents must be accentuated yet more to diminished these wrongs. The conditions of functioning are in the domain of preconization rules for a good radiographic analysis. (author)

  12. Distribution of kerosene components in rats following dermal exposure.

    Science.gov (United States)

    Tsujino, Y; Hieda, Y; Kimura, K; Eto, H; Yakabe, T; Takayama, K; Dekio, S

    2002-08-01

    The systemic distribution of kerosene components in blood and tissues was analysed in rats following dermal exposure. Four types of trimethylbenzenes (TMBs) and aliphatic hydrocarbons (AHCs) with carbon numbers 9-16 (C(9)-C(16)) were analysed as major kerosene components by capillary gas chromatography/mass spectrometry (GC/MS). The kerosene components were detected in blood and all tissues after a small piece of cotton soaked with kerosene was applied to the abdominal skin. The amounts of TMBs detected were higher than those of AHCs. Greater increases in TMB levels were found in adipose tissue in an exposure duration-dependent manner. The amounts of TMBs detected were only at trace levels following post-mortem dermal exposure to kerosene. These findings suggest that kerosene components were absorbed percutaneously and distributed to various organs via the blood circulation. Post-mortem or ante-mortem exposure to kerosene could be distinguished when the exposure duration was relatively long. Adipose tissue would seem to be the most useful for estimating the degree of kerosene exposure.

  13. [Features of Bordetella pertussis, Bordetella spp. infection and whopping cough in Córdoba province, Argentina].

    Science.gov (United States)

    Giayetto, Víctor O; Blanco, Sebastián; Mangeaud, Arnaldo; Barbás, María G; Cudolá, Analía; Gallego, Sandra V

    2017-04-01

    Whooping cough is a re-emerging infection in the world and Latin America. It was considered relevant to investigate the clinical and epidemiological profile of Bordetella spp. and Bordetella pertussis infection in Córdoba province, Argentina; evaluating, at the same time, the co-infection with virus producing respiratory infections that may be confused with whooping cough. All whooping cough suspected cases were studied by Polimerase Chain Reaction, amplifying the repeated insertion sequence (IS) 481 and the promoter gene encoding pertussis toxin, between 2011 and 2013. The data were obtained from the clinical and epidemiological records. From 2,588 whooping cough suspected cases, 11.59% was infected by Bordetella spp. and 9.16% was confirmed as Bordetella pertussis infection. The rate of infection was 7.22 and 1.84 per 100,000 for 2011 and 2012, respectively. The infection presented a seasonal tendency and it was mainly found on the group of children between 13 and 24 months old. The co-infection with virus producing respiratory infections, were uncommon. Paroxysmal cough, cyanosis and/or vomiting were predictors of the infection for Bordetella pertussis. To deal with the re-emergence of whooping cough is important the knowledge of the regional epidemiological situation. This paper shows the situation of these infections in the regional clinical and epidemiological context, and makes the information available for health decision-making.

  14. Increasing Risk of Disturbed Root Development in Permanent Teeth in Childhood Cancer Survivors Undergoing Cancer Treatment at Older Age.

    Science.gov (United States)

    Tanaka, Miyuki; Kamata, Takahiro; Yanagisawa, Ryu; Morita, Daisuke; Saito, Shoji; Sakashita, Kazuo; Shiohara, Masaaki; Kurita, Hiroshi; Koike, Kenichi; Nakazawa, Yozo

    2017-04-01

    Structural anomalies of teeth are observed at high rates in childhood cancer survivors (CCS). Several therapeutic exposures have been shown to be associated with dental developmental disturbances. This study was conducted to analyze the risk factors for dental developmental abnormality (DDA) and investigate the association between age at the time of cancer treatment and DDA in CCS. Fifty-six CCS were enrolled. Orthopantomography and dental examination were performed in all the patients. We evaluated the prevalence of DDA and analyzed the risk factors for each type of DDA. DDAs were observed in 46.4% of CCS, including hypodontia in 9 (16.1%), abnormal roots in nine (16.1%), enamel defects/hypoplasia in 6 (10.7%), and microdontia in 12 (21.4%) patients. The number of patients with abnormal roots was significantly higher in the group treated with stem cell transplantation or at an age older than 4 years. We observed that the formation period of abnormal teeth coincided with the treatment period in the majority of CCS with DDA. Particularly regarding the root abnormality, treatment at elder age may be a risk factor for root developmental disturbances. Risk evaluation, appropriate follow-up, and early detection of dental issues are required for all CCS.

  15. Effect aquadest-extracted Gloriosa superba seed as mutagen on morphology of Artemisia annua

    Science.gov (United States)

    Rahmawati, S. I.; Susilowati, A.; Yunus, A.; Widyastuti, Y.

    2018-03-01

    Gloriosa superba is a plant that contains colchicine in all parts of organs, especially in the seeds. Its extract is as a mutagen to produce plants with polyploid cells. Artemisia annua is a plant that produces active ingredients artemisinin as malarial drugs, hemorrhoids therapy, aromatherapy, antiviral, anticancer, and anti-bacterial. The aims of this research was to determine the effect aquadest-extracted Gloriosa superba seed as a mutagen to Artemisia annua morphology. Extraction of Gloriosa superba seeds obtained from Sukoharjo using maceration method with aquadest solvent (1: 1). The extracts were diluted (0, 25, 50, 75 and 100%) for Artemisia annua sprinkling with different times (0, 30, 60 and 90 minutes). Observations of morphology Artemisia annua included height, stem circumference, number of branches, number of leaves, leaf width and leaf length. The treatments did not affect plant morphology observation included height, stem circumference, number of branches, number of leaves, leaf width, and leaf length. The EB treatment (100%, 30 minutes) was higher (120 cm) than other. In all treatments stem circumference about 2.5 cm, number of branches ranged between 40-50, leaves width ranged 9-16c m, and leaf length ranged 8-15 cm.

  16. Quantitative analysis of velopharyngeal movement using a stereoendoscope: accuracy and reliability of range images.

    Science.gov (United States)

    Nakano, Asuka; Mishima, Katsuaki; Shiraishi, Ruriko; Ueyama, Yoshiya

    2015-01-01

    We developed a novel method of producing accurate range images of the velopharynx using a three-dimensional (3D) endoscope to obtain detailed measurements of velopharyngeal movements. The purpose of the present study was to determine the relationship between the distance from the endoscope to an object, elucidate the measurement accuracy along the temporal axes, and determine the degree of blurring when using a jig to fix the endoscope. An endoscopic measuring system was developed in which a pattern projection system was incorporated into a commercially available 3D endoscope. After correcting the distortion of the camera images, range images were produced using pattern projection to achieve stereo matching. Graph paper was used to measure the appropriate distance from the camera to an object, the mesial buccal cusp of the right maxillary first molar was measured to clarify the range image stability, and an electric actuator was used to evaluate the measurement accuracy along the temporal axes. The measurement error was substantial when the distance from the camera to the subject was >6.5 cm. The standard error of the 3D coordinate value produced from 30 frames was within 0.1 mm (range, 0.01-0.08 mm). The measurement error of the temporal axes was 9.16% in the horizontal direction and 9.27% in the vertical direction. The optimal distance from the camera to an object is movements.

  17. Nutrients, phytochemicals and antioxidant activities of 26 kidney bean cultivars.

    Science.gov (United States)

    Kan, Lijiao; Nie, Shaoping; Hu, Jielun; Wang, Sunan; Cui, Steve W; Li, Yawen; Xu, Sifan; Wu, Yue; Wang, Junqiao; Bai, Zhouya; Xie, Mingyong

    2017-10-01

    Detailed characterization in nutrients and phytochemicals with antioxidant activities of 26 kidney beans was performed. The kidney beans contained high levels of dietary fiber (29.32-46.77%), resistant starch (9.16-18.09%) and protein (22.06-32.63%) but low levels of lipid (1.05-2.83%) and sugars (1.55-9.07%). The monosaccharide composition of soluble fiber was dominated by arabinose, galactose, mannose and galacturonic acid. The ratio of essential amino acid to the total amino acid was ranged from 0.29 to 0.36. The predominant fatty acid was polyunsaturated fatty acids, accounting for 47.54-67.26% of total fatty acids. The total tocopherol content was in the range of 12.83-68.35 μg/g, predominantly γ-tocopherol, followed by δ-tocopherol. In addition, certain levels of total phenolics and flavonoids with respective values of 0.25-3.79 mg gallic acid equivalent/g dry weight and 0.19-7.05 mg rutin equivalent/g dry weight resulted in significant antioxidant activities. And a good correlation was observed between TPC and FRAP values (R2 = 0.8030). The results indicated that kidney beans are excellent sources of health-promoting compounds. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Comprehensive analysis for major, minor and trace element contents and Sr-Nd-Pb-Hf isotope ratios in sediment reference materials, JSd-1 and MAG-1

    Digital Repository Service at National Institute of Oceanography (India)

    Nath, B.N.; Makishima, A.; Noordmann, J.; Tanaka, R.; Nakamura, E.

    . For this purpose, we divided elements into two groups: Group I and Group II. Elements in Group I (Li, Be, Na, Mg, Al, P, K, Ca, Sc, V, Mn, Fe, Co, Ni, Cu, Zn, Ga, Rb, Sr, Y, In, Cs, Ba, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Tl, Pb, Bi, Th and U... S S F (HR) 8.9 9.5 11.3 9.7 8.4 10.6 9.7 1 1 1 0.9 16.1 17.2 < 0 . 2 V I D - I S S F ( M R ) 64 68 66 51 52 64 61.2 12 76 144 140 3.5 C o I D - I S S F ( M R ) 11.5 10.0 11.2 10.5 10.5 10.4 10.7 5 1 1.2 3.59 20.4 0.05 Ni I D - I S S F (HR) 10 7 6 8 9...

  19. Structural and functional annotation of citrate synthase from Aspergillus niger ANJ-120.

    Science.gov (United States)

    Mustafa, Ghulam; Arif, Rawaba; Bukhari, Shazia Anwer; Ali, Muhammad; Sharif, Sumaira; Atta, Asia

    2018-03-01

    Citrate synthase (CS) is involved in citric acid biosynthesis which is a well-established metabolic pathway. The condensation of acetyl-CoA with oxaloacetate is catalyzed by CS. Citric acid (CA) has a number of applications in pharmaceutical industry. CA in combination with bicarbonates is used as an effervescent in the preparations of tablets and powders. It has also been used as an anticoagulant and acidulant to form mild astringent. In current study, detailed structural and functional analyses of CS protein were carried out using various bioinformatics tools. Structural modeling was also done by building 3D model of CS from Aspergillus niger ANJ-120 using Modeller 9.16 software. The 3D Model was then evaluated using different online approaches. Furthermore, superimposition of query and template structures, Root Mean Squared Deviation and visualization of generated model were done through UCSF Chimera 1.5.3. Even though various roles of CS protein were already known and verified experimentally, here we presented a structural analysis of CS protein. The structural investigation of CS protein will be helpful for protein engineering strategies and understanding the interactions among proteins. Due to large number of applications, the production of citric acid by A. niger and its bioinformatics studies will offer substantial improvement in commercial scale intensification of this useful product.

  20. Actinomyces timonensis sp. nov., isolated from a human clinical osteo-articular sample.

    Science.gov (United States)

    Renvoise, Aurélie; Raoult, Didier; Roux, Véronique

    2010-07-01

    Gram-positive, non-spore-forming rods were isolated from a human osteo-articular sample (strain 7400942(T)). Based on cellular morphology and the results of biochemical analysis, this strain was tentatively identified as a novel species of the genus Actinomyces. Phylogenetic analysis based on 16S rRNA gene sequence comparisons showed that the bacterium was closely related to the type strain of Actinomyces denticolens (96.9 % 16S rRNA gene sequence similarity). A comparison of biochemical traits showed that strain 7400942(T) was distinct from A. denticolens in a number of characteristics, i.e. in contrast with A. denticolens, strain 7400942(T) was negative for nitrate reduction and for beta-galactosidase, alpha-glucosidase and alanine arylamidase activities, it was positive for acid production from N-acetylglucosamine, melezitose and glycogen, and it was negative for acid production from turanose. Matrix-assisted laser-desorption/ionization time-of-flight MS protein analysis confirmed that strain 7400942(T) represents a novel species, as scores obtained for its spectra were significant (>2.2) only with strain 7400942(T). On the basis of phenotypic data and phylogenetic inference, it is proposed that this strain should be designated Actinomyces timonensis sp. nov.; the type strain is strain 7400942(T) (=CSUR P35(T)=CCUG 55928(T)).

  1. C-reactive protein and substance use disorders in adolescence and early adulthood: a prospective analysis.

    Science.gov (United States)

    Costello, E Jane; Copeland, William E; Shanahan, Lilly; Worthman, Carol M; Angold, Adrian

    2013-12-01

    Dysregulated immune function and elevated inflammation markers are seen in adults with chronic diseases, including some psychiatric disorders, but evidence on inflammation in the case of drug abuse is conflicting. To test the concurrent and predictive relations between C-reactive protein (CRP) and use and abuse of alcohol, nicotine and cannabis in a longitudinal, population sample of adolescents and young adults, at the period of highest increase in drug use. Data from the prospective population-based Great Smoky Mountains Study (N=1420) were used, covering children in the community assessed at ages 9-16, 19, and 21. Structured interviews were used to assess substance abuse symptoms and DSM-IV substance use disorders. Bloodspots were collected at each assessment and assayed for CRP. CRP levels were higher in the presence of nicotine, alcohol, and cannabis use and nicotine dependence. In prospective analyses, higher CRP levels predicted cannabis use and nicotine dependence, and nicotine use predicted higher CRP levels, once covariates were included in the models. Significant covariates were age, race (American Indian), and obesity. The inter-relationship of CRP and substance abuse has implications for the later health risks associated with early drug and alcohol use and abuse. Copyright © 2013. Published by Elsevier Ireland Ltd.

  2. High-resolution CT in paraquat poisoning of the lung : role of prognosis prediction

    International Nuclear Information System (INIS)

    Kim, Kyoung Suk; Kim, Young Tong; Kwon, Eun Joo; Choi, Choung Sik; Im, Han Heag; Park, Jai Soung; Kim, Il Young

    1998-01-01

    The purpose of this study is to evaluate the prognosis of patients with paraquat poisoning by measuring the extent of lung involvement, as seen on HRCT. Forty-one patients with paraquat poisoning were treated according to our hospital's routine protocol and underwent HRCT scanning 1-21 (mean 7-8) days after. In 31, the results were abnormal, and these were retrospectively analysed. Differences in the extent of lung involvement, patient age, ingested amount of paraquat, and blood WBC count were compared between the group of survivors and those who had died. Among the 31 patients with abnormal HRCT findings, 11 died and 20 patient survived. The extent of lung involvement among the group of survivors was 14.8 ± 14.8 %; among the decreased group, it was 72.3 ± 16.3 %. The age of the survivors was 37.5 ± 13.5 (11-67) years, while that of the deceased was 25 ± 8.9 (16-41) years. Those who died showed a significantly higher significant difference in blood WBC count and ingested amount of paraquat between the two groups (p>0.05). In paraquat poisoning, the extent of lung involvement on HRCT, useful for prediction of the prognosis and severity of poisoning. (author). 11 refs., 1 tab., 4 figs

  3. Children's experiences of attitudes and rules for going to the toilet in school.

    Science.gov (United States)

    Lundblad, Barbro; Hellström, Anna-Lena; Berg, Marie

    2010-06-01

    School children often base their toilet habits on behavioural and social reasons. Bladder emptying problems, urinary tract infections and constipation are common health problems which are also associated with irregular toilet habits. School rules for going to the toilet have been shown to create difficulties for school children with bladder dysfunction. Aim of this study was to describe children's experiences of school rules for going to the toilet and their significance for the children. Individual open-ended questions with 19 schoolchildren aged 9-16 in elementary schools. To manage the children's toilet needs, teachers used rules designed for maintaining order in the classroom. The children saw their toilets needs as a private matter and experienced it complicated to go to the toilet during recess as time was short and the risk for violation of their integrity was at its highest. The most frustrating when to comply with rules during lessons was to be forced to, in front of all their classmates, make public the need to go to the toilet: i.e the most private was exposed to the disclosure. The rules for going to the toilet came from the teachers' need for maintaining order in the classroom and were not adapted to the children's physical and developmental needs. To violate the integrity of children can affect their willingness to go to the school toilet which in turn affects their wellbeing during school time.

  4. Study on the incidence of testicular and epididymal appendages in patients with cryptorchidism

    Directory of Open Access Journals (Sweden)

    Favorito Luciano A.

    2004-01-01

    Full Text Available OBJECTIVE: To study the incidence of testicular and epididymal appendages in patients with cryptorchidism. MATERIALS AND METHODS: We studied 65 patients with cryptorchidism, totalizing 83 testes and 40 patients who had prostate adenocarcinoma and hydrocele (control group, totalizing 55 testes. The following situations were analyzed: I absence of testicular and epididymal appendages, II presence of testicular appendage only, III presence of epididymal appendage, IV presence of testicular and epididymal appendage, V presence of 2 epididymal appendages and 1 testicular appendage and VI presence of paradidymis or vas aberrans of Haller. RESULTS: In patients with cryptorchidism we found testicular appendages in 23 cases (41.8%, epididymal appendages in 9 (16.3%, testicular and epididymal appendage in 8 (14.5%, 2 epididymal appendages and 1 testicular in 1 (1.8% and absence of appendages in 14 (25.4%. In the control group, we found testicular appendages in 29 (34.9%, epididymal appendages in 19 (22.8%, testicular and epididymal appendage in 7 (8.4%, and absence of appendages in 28 (33.7%, we did not find 2 epididymal appendages in this group, and none of the patients in the 2 groups presented paradidymis or vas aberrans of Haller. CONCLUSION: The occurrence of testicular and epididymal appendages is quite variable. There was no statistically significant difference in the incidence and distribution of the testicular and epididymal appendages between patients with cryptorchidism and those from the control group.

  5. Simultaneous determination of saflufenacil and its two metabolites in soil samples by ultra-performance liquid chromatography with tandem mass spectrometry.

    Science.gov (United States)

    Lan, Meijing; Li, Shuying; Xu, Zhenzhen; Tian, Chunxia; Yang, Mei; Gui, Wenjun; Zhu, Guonian

    2014-03-01

    Saflufenacil is a new protoporphyrinogen-IX-oxidase inhibitor herbicide. When used, it can enter the soil and has a high risk to reach and contaminate groundwater and aquatic systems. A rapid and sensitive method of ultra-performance LC with MS/MS was developed for the simultaneous determination of saflufenacil and its two metabolites in soil samples. A modified quick, easy, cheap, effective, rugged, and safe method was applied as the pretreatment procedure. The method was validated by five types of soil samples collected from several regions of China, which all showed good linearity (R(2) ≥ 0.9914) and precision (RSD ≤ 26.2%). The average recoveries of the three analytes ranged between 74.1 and 118.9% at spiking levels of 3-300 μg/kg. The method limits of detection (S/N 3:1) and method limits of quantification (S/N 10:1) achieved are in the ranges of 0.25-2.75 and 0.83-9.16 μg/kg, respectively. This indicated that the developed ultra-performance LC with MS/MS method is a promising analytical tool for monitoring the environmental risks posed by saflufenacil. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Synthesis and Antiproliferative Activity of Thioxoflavones Mannich Base Derivatives.

    Science.gov (United States)

    Li, Wei; Li, Xueli; Liu, Manhui; Wang, Qiuan

    2017-07-01

    Two series of 12 novel thioxoflavones Mannich base derivatives 5a-f and 6a-f were synthesized via Mannich reaction of 4',7-dimethoxy-5-hydroxyflavothione (3) or 3',4',7-trimethoxy-5-hydroxyflavothione (4) with appropriate aliphatic amines or alicyclic amines and formaldehyde. Thioxoflavones 3 and 4 were prepared from 4',7-dimethoxy-5-hydroxyflavone (1) and 3',4',7-trimethoxy-5-hydroxyflavone (2) with Lawesson's reagent, respectively. Their antiproliferative activities in vitro were evaluated on a panel of three human cell lines (HeLa, HCC1954, and SK-OV-3) by CCK-8 assay. The results showed that most of the thioxoflavones and their Mannich base derivatives exhibited potential antiproliferative activities on the tested cancer cell lines, with IC 50 values ranging from 9.16 to 55.50 μM. In particular, thioxoflavone 4 and the thioxoflavone Mannich base derivatives 5a and 5d showed the best antiproliferative activity on all three human cancer cell lines; they are promising candidates worthy of further development. The structures of all synthesized compounds were confirmed by 1 H NMR, 13 C NMR, IR, and MS techniques. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Sleep duration or bedtime? Exploring the association between sleep timing behaviour, diet and BMI in children and adolescents.

    Science.gov (United States)

    Golley, R K; Maher, C A; Matricciani, L; Olds, T S

    2013-04-01

    To determine whether sleep timing behaviour is associated with energy intake and diet quality in children and adolescents. Cross-sectional analysis of nationally representative survey data. A total of 2200 participants of the 2007 Australian National Children's Nutrition and Physical Activity Survey aged 9-16 years with 2 days of food intake data, 4 days of use of time data and complete anthropometry. Participants were grouped into one of four sleep-wake behaviour categories: early bed-early rise (EE); early bed-late rise (EL); late bed-early rise (LE) and late bed-late rise (LL). The four categories were compared for body mass index (BMI) z-score, energy intake and diet quality assessed using the Dietary Guideline Index for Children and Adolescents. Analyses were adjusted for survey design, sociodemographic characteristics, sleep duration and physical activity level (PAL). In adjusted multivariate regression models with sleep timing behaviour group as the independent variable, the 'LL' category compared with the 'EE' category had a higher BMI z-score (β=0.20, 95% confidence interval (CI) 0.06 to 0.34, P=0.007), and lower diet quality (β=-4.0, 95% CI -5.7 to -2.3, Psleep duration (β=-4.5 kJ, 95% CI -6.7 to -2.4, Psleep timing behaviour. Late bedtimes and late wake up times are associated with poorer diet quality, independent of sleep duration, PAL and child and sociodemographic characteristics.

  8. Is autoimmune thyroid dysfunction a risk factor for gestational diabetes?

    Science.gov (United States)

    Pascual Corrales, Eider; Andrada, Patricia; Aubá, María; Ruiz Zambrana, Alvaro; Guillén Grima, Francisco; Salvador, Javier; Escalada, Javier; Galofré, Juan C

    2014-01-01

    Some recent studies have related autoimmune thyroid dysfunction and gestational diabetes (GD). The common factor for both conditions could be the existence of pro-inflammatory homeostasis. The study objective was therefore to assess whether the presence of antithyroid antibodies is related to the occurrence of GD. Fifty-six pregnant women with serum TSH levels ≥ 2.5 mU/mL during the first trimester were retrospectively studied. Antithyroid antibodies were measured, and an O'Sullivan test was performed. GD was diagnosed based on the criteria of the Spanish Group on Diabetes and Pregnancy. Positive antithyroid antibodies were found in 21 (37.50%) women. GD was diagnosed in 15 patients, 6 of whom (10.71%) had positive antibodies, while 9 (16.07%) had negative antibodies. Data were analyzed using exact logistic regression by LogXact-8 Cytel; no statistically significant differences were found between GD patients with positive and negative autoimmunity (OR = 1.15 [95%CI = 0.28-4.51]; P=1.00). The presence of thyroid autoimmunity in women with TSH above the recommended values at the beginning of pregnancy is not associated to development of GD. However, GD prevalence was higher in these patients as compared to the Spanish general population, suggesting the need for closer monitoring in pregnant women with TSH levels ≥ 2.5 mU/mL. Copyright © 2013 SEEN. Published by Elsevier Espana. All rights reserved.

  9. Nature of H-mordenite deactivation phenomena during SCR of NO{sub x}

    Energy Technology Data Exchange (ETDEWEB)

    Lezcano, M.; Ribotta, A.; Miro, E.; Lombardo, E.; Petunchi, J. [Instituto de Investigaciones en Catalisis y Petroquimica, Santa Fe (Argentina)] [and others

    1996-12-31

    Studies of the selective catalytic reduction (SCR) of nitrogen oxide with methane over H-mordenites were made to develop a basic understanding of the role of acid sites in this reaction and the mechanism of deactivation of these solids. A series of H-mordenites with varying Si/Al ratios (5.9-16.9) were prepared by acid leaching. They were thoroughly characterized before and after reaction by {sup 27}AlMAS, NMR, XRD, FTIR spectroscopy, N{sub 2} adsorption and ammonia TPD. A linear correlation was found between the maximum conversion of NO to N{sub 2}, the lattice aluminum content and the concentration of strong acid sites measured by ammonia chemisorption. The catalysts were partially deactivated after being on stream at 650{degrees}C, subsequently reaching a stable behavior. The origin of this phenomenon could be traced back to the additional dealumination occurring at high temperatures in the reacting stream. This additional expulsion of aluminum from the lattice caused a proportional decrease in the concentration of strong acid sites.

  10. Spectroscopic characterization of dealuminated H-mordenites: The role of different aluminum species on the SCR of NO with methane

    Energy Technology Data Exchange (ETDEWEB)

    Lezcano, M.; Ribotta, A.; Miro, E. [Instituto de Investigaciones en Catalisis y Petroquimica, Sante Fe (Argentina)] [and others

    1997-06-01

    In order to understand the role of different aluminum species in the selective catalytic reduction of nitrogen oxides with methane over H-mordenites, solids with varying Si/Al ratios (5.9-16.9) were prepared by acid leaching. They were thoroughly characterized before and after reaction. The distribution of Al was determined through {sup 27}Al MAS NMR. All the samples presented three signals, one at 54 ppm corresponding to lattice Al{sup IV}, another at 0 ppm associated with octahedrally coordinated Al, and a broad band, BB (ca 100 ppm wide), assigned to aluminum containing species. As the spinning rate increased up to 11.3 kHz, a decrease of the BB intensity and an increase of the Al{sup IV} signal took place, while the Al{sup VI} slightly increased. The best estimate of lattice aluminum was obtained from the Al{sup IV} peak intensity. Despite the high spinning rate employed, it was possible to observe only between 70-80% of the total Al present in the samples. The catalysts were also analyzed by XRD, FTIR, and {sup 129}Xe NMR of physisorbed Xenon. 48 refs., 13 figs., 6 tabs.

  11. The Role of N-Methyl D-Aspartate Receptors on Pain Transmission

    Directory of Open Access Journals (Sweden)

    Yasemin Gunes

    2012-02-01

    Full Text Available Aim : In the experimental studies, NMDA (N-methyl-D-aspartate receptors play important role in the mechanism of action among the drugs used for the treatment of pain. The NMDA receptors in the dorsal horn of spinal cord is essential for central sensitization and the central facilitation of pain transmission produced by peripheral injury. The aim of this study was to evaluate the contributions of peripheral NMDA receptor agonist and antagonists in peripheral pain transmission. Material-Method : In the present study, N methyl aspartic acid (NMDA and antagonist ( MK-801 were administered intraplantarily to investigate withdrawal effects, the dose and time dependent latency using thermal plantar test method in rats. Results : MK-801 caused dose-dependent thermal anti-nociceptive effects, whereas NMDA led to reduction in the thermal nociceptive latency and hyperalgesia. Conclusion : Peripheral NMDA receptors may play a dominant role in the transmission of pain information. [Cukurova Med J 2012; 37(1.000: 9-16

  12. 2,4-Dichlorophenol Enzymatic Removal and Its Kinetic Study Using Horseradish Peroxidase Crosslinked to Nano Spray-Dried Poly(Lactic-Co-Glycolic Acid) Fine Particles.

    Science.gov (United States)

    Dahili, Laura Amina; Nagy, Endre; Feczkó, Tivadar

    2017-04-28

    Horseradish peroxidase (HRP) catalyzes the oxidation of aromatic compounds by hydrogen peroxide via insoluble polymer formation, which can be precipitated from the wastewater. For HRP immobilization, poly(lactic-co-glycolic acid) (PLGA) fine carrier supports were produced by using the Nano Spray Dryer B-90. Immobilized HRP was used to remove the persistent 2,4-dichlorophenol from model wastewater. Both extracted (9-16 U/g) and purified HRP (11-25 U/g) retained their activity to a high extent after crosslinking to the PLGA particles. The immobilized enzyme activity was substantially higher in both the acidic and the alkaline pH regions compared with the free enzyme. Optimally, 98% of the 2,4-dichlorophenol could be eliminated using immobilized HRP due to catalytic removal and partly to adsorption on the carrier supports. Immobilized enzyme kinetics for 2,4-dichlorophenol elimination was studied for the first time, and it could be concluded that competitive product inhibition took place.

  13. Magnetic Resonance Imaging of Anterior Cruciate Ligament Tears: Evaluation of Standard Orthogonal and Tailored Paracoronal Images

    Energy Technology Data Exchange (ETDEWEB)

    Duc, S.R.; Zanetti, M.; Kramer, J.; Kaech, K.P.; Zollikofer, C.L.; Wentz, K.U. [Cantonal Hospital, Inst. of Radiology, Winterthur (Switzerland). MR Research Group

    2005-11-01

    Purpose: To evaluate the three standard orthogonal imaging planes and a paracoronal imaging plane for anterior cruciate ligament (ACL) tears. Material and Methods: Ninety patients (91 knees; 29 F and 61 M) aged between 15 and 84 years (mean 36.9{+-}16.4 years) underwent magnetic resonance imaging (MRI) of the knee prior to arthroscopy. At surgery, 32 knees had an intact ACL, 4 a partial tear, and 55 a complete ACL tear. In all patients, axial, sagittal, coronal, and paracoronal T2-weighted turbo-SE images were acquired. The ACL was classified as intact, partially, or completely torn. Partial and complete tears were combined for statistical evaluation. Results: Partial ACL tears (four cases) were not correctly diagnosed at MRI except in one knee by one observer on coronal images. Sensitivity in detecting ACL tears was 95%/63% (reader1/reader2) in the axial, 93%/95% in the sagittal, 93%/86% in the coronal, and 100%/93% in the paracoronal plane. Specificity was 75%/81% in the axial, 72%/81% in the sagittal, 78%/94% in the coronal, and 78%/88% in the paracoronal plane. Conclusion: ACL tears can be diagnosed accurately with each of the standard orthogonal planes. Based on reader confidence and interobserver agreement paracoronal images may be useful in equivocal cases.

  14. Semi-supervised Discriminative Structured Prediction

    Science.gov (United States)

    2013-10-30

    CV Glass 214 6 10 5-CV Wine 178 3 13 5-CV Vowel 990 11 10 5-CV Table 4: Description of datasets An overview of these datasets is shown in Ta- ble 4...Yeast 43.65(2.6) 44.73(4.5) 43.6(3.5) 42.43(2.8) glass 29.52(10.7) 31.9(8.0) 27.0(7.4) 26.19(10.8) wine 8.57(4.9) 7.43(4.8) 7.54(5.3) 3.43(4.7) vowel ...3.6) 40.23(2.5) glass 27.14(9.3) 29.52(9.2) 24.76(8.7) 24.0(6.8) 24.76(9.9) wine 8.57(4.9) 9.16(5.3) 7.43(4.8) 7.54(5.3) 3.43(4.7) vowel 5.96(2.9

  15. Analysis on relevance between c-myc gene and thymic lymphomas of mic induced by ionizing radiation

    International Nuclear Information System (INIS)

    Yu Lei; Liu Yongzhe; Sun Shilong; Fang Fang; Gong Hongwei; Chen Qiang; Ju Guizhi

    2009-01-01

    Objective: To study the change of c-myc gene expression in thymic lymphomas of mice induced by ionizing radiation and provide theoretical basis for mechanism of radiation carcinogenesis. Methods: The thymic lymphomas models of BALB/c mice were made by X-ray (dose rate: 0.287 Gy · min -1 ; total dose: 7 Gy) exposuring, 6 months later they were killed, then total RNA and total protein were extracted from thymic lymphomas and normal thymus tissue and cDNA was synthesized, the expressions of c-myc mRNA and protein in thymic lymphomas induced by ionizing radiation and normal thymus were detected by quantitative real-time PCR and Western blotting respectively. Results: The expression of c-myc mRNA in thymic lymphomas (9.16 ± 4.66) was higher than that in normal thymus tissue (1.16 ± 0.54) (P<0.01). The expression of c-myc protein in thymic lymphomas was higher than that in normal thymus tissue. Conclusion: There is relevance between c-myc gene and thymic lymphomas induced by ionizing radiation, c-myc gene might be susceptibility gene of radiation carcinogenesis. (authors)

  16. The Impact of Pollution Prevention on Toxic Environmental Releases from U.S. Manufacturing Facilities.

    Science.gov (United States)

    Ranson, Matthew; Cox, Brendan; Keenan, Cheryl; Teitelbaum, Daniel

    2015-11-03

    Between 1991 and 2012, the facilities that reported to the U.S. Environmental Protection Agency's Toxic Release Inventory (TRI) Program conducted 370,000 source reduction projects. We use this data set to conduct the first quasi-experimental retrospective evaluation of how implementing a source reduction (pollution prevention) project affects the quantity of toxic chemicals released to the environment by an average industrial facility. We use a differences-in-differences methodology, which measures how implementing a source reduction project affects a facility's releases of targeted chemicals, relative to releases of (a) other untargeted chemicals from the same facility, or (b) the same chemical from other facilities in the same industry. We find that the average source reduction project causes a 9-16% decrease in releases of targeted chemicals in the year of implementation. Source reduction techniques vary in effectiveness: for example, raw material modification causes a large decrease in releases, while inventory control has no detectable effect. Our analysis suggests that in aggregate, the source reduction projects carried out in the U.S. since 1991 have prevented between 5 and 14 billion pounds of toxic releases.

  17. Biosynthesis and metabolic engineering of palmitoleate production, an important contributor to human health and sustainable industry.

    Science.gov (United States)

    Wu, Yongmei; Li, Runzhi; Hildebrand, David F

    2012-10-01

    Palmitoleate (cis-Δ9-16:1) shows numerous health benefits such as increased cell membrane fluidity, reduced inflammation, protection of the cardiovascular system, and inhibition of oncogenesis. Plant oils containing this unusual fatty acid can also be sustainable feedstocks for producing industrially important and high-demand 1-octene. Vegetable oils rich in palmitoleate are the ideal candidates for biodiesel production. Several wild plants are known that can synthesize high levels of palmitoleate in seeds. However, low yields and poor agronomic characteristics of these plants limit their commercialization. Metabolic engineering has been developed to create oilseed crops that accumulate high levels of palmitoleate or other unusual fatty acids, and significant advances have been made recently in this field, particularly using the model plant Arabidopsis as the host. The engineered targets for enhancing palmitoleate synthesis include overexpression of Δ9 desaturase from mammals, yeast, fungi, and plants, down-regulating KASII, coexpression of an ACP-Δ9 desaturase in plastids and CoA-Δ9 desaturase in endoplasmic reticulum (ER), and optimizing the metabolic flux into triacylglycerols (TAGs). This review will mainly describe the recent progress towards producing palmitoleate in transgenic plants by metabolic engineering along with our current understanding of palmitoleate biosynthesis and its regulation, as well as highlighting the bottlenecks that require additional investigation by combining lipidomics, transgenics and other "-omics" tools. A brief review of reported health benefits and non-food uses of palmitoleate will also be covered. Copyright © 2012. Published by Elsevier Ltd.

  18. Reducing errors benefits the field-based learning of a fundamental movement skill in children.

    Science.gov (United States)

    Capio, C M; Poolton, J M; Sit, C H P; Holmstrom, M; Masters, R S W

    2013-03-01

    Proficient fundamental movement skills (FMS) are believed to form the basis of more complex movement patterns in sports. This study examined the development of the FMS of overhand throwing in children through either an error-reduced (ER) or error-strewn (ES) training program. Students (n = 216), aged 8-12 years (M = 9.16, SD = 0.96), practiced overhand throwing in either a program that reduced errors during practice (ER) or one that was ES. ER program reduced errors by incrementally raising the task difficulty, while the ES program had an incremental lowering of task difficulty. Process-oriented assessment of throwing movement form (Test of Gross Motor Development-2) and product-oriented assessment of throwing accuracy (absolute error) were performed. Changes in performance were examined among children in the upper and lower quartiles of the pretest throwing accuracy scores. ER training participants showed greater gains in movement form and accuracy, and performed throwing more effectively with a concurrent secondary cognitive task. Movement form improved among girls, while throwing accuracy improved among children with low ability. Reduced performance errors in FMS training resulted in greater learning than a program that did not restrict errors. Reduced cognitive processing costs (effective dual-task performance) associated with such approach suggest its potential benefits for children with developmental conditions. © 2011 John Wiley & Sons A/S.

  19. Microencapsulation by spray drying of lemon essential oil: Evaluation of mixtures of mesquite gum-nopal mucilage as new wall materials.

    Science.gov (United States)

    Cortés-Camargo, Stefani; Cruz-Olivares, Julian; Barragán-Huerta, Blanca E; Dublán-García, Octavio; Román-Guerrero, Angélica; Pérez-Alonso, César

    2017-06-01

    Mesquite gum (MG) and nopal mucilage (NM) mixtures were used for microencapsulation of lemon essential oil (LEO) by spray drying. Emulsions of MG, NM and MG-NM mixtures (25-75, 50-50, 75-25) were evaluated according to the droplet size (1.49-9.16 μm), viscosity and zeta potential (-16.07 to -20.13 mV), and microcapsules were characterised in particle size (11.9-44.4 μm), morphology, volatile oil retention (VOR) (45.9-74.4%), encapsulation efficiency (EE) (70.9-90.6%), oxidative stability and thermal analysis. The higher concentration of MG led to smaller droplet sizes and lower viscosity in the emulsions, and smaller particle sizes with the highest VOR in microcapsules. The higher concentration of NM induced to higher viscosity in the emulsions, and larger particle sizes with the highest values of EE and oxidative stability in microcapsules. This work shows evidence that MG-NM mixtures can have synergic effect in desirable characteristics such as retention and shelf life extension of LEO in microcapsules.

  20. Working memory arrest in children with high-functioning autism compared to children with attention-deficit/hyperactivity disorder: results from a 2-year longitudinal study.

    Science.gov (United States)

    Andersen, Per N; Skogli, Erik W; Hovik, Kjell T; Geurts, Hilde; Egeland, Jens; Øie, Merete

    2015-05-01

    The aim of this study was to analyse the development of verbal working memory in children with high-functioning autism compared to children with attention-deficit/hyperactivity disorder and typically developing children. A total of 34 children with high-functioning autism, 72 children with attention-deficit/hyperactivity disorder and 45 typically developing children (age 9-16 years) were included at baseline and followed up approximately 25 months later. The children were given a letter/number sequencing task to assess verbal working memory. The performance of children with high-functioning autism on verbal working memory did not improve after 2 years, while improvement was observed in children with attention-deficit/hyperactivity disorder and typically developing children. The results indicate a different developmental trajectory for verbal working memory in children with high-functioning autism compared to children with attention-deficit/hyperactivity disorder and typically developing children. More research is needed to construct a developmental framework more suitable for children with autism spectrum disorder. © The Author(s) 2014.

  1. Streptococcus pharyngis sp. nov., a novel streptococcal species isolated from the respiratory tract of wild rabbits.

    Science.gov (United States)

    Vela, Ana I; Casas-Díaz, Encarna; Lavín, Santiago; Domínguez, Lucas; Fernández-Garayzábal, Jose F

    2015-09-01

    Four isolates of an unknown Gram-stain-positive, catalase-negative coccus-shaped organism, isolated from the pharynx of four wild rabbits, were characterized by phenotypic and molecular genetic methods. The micro-organisms were tentatively assigned to the genus Streptococcus based on cellular morphological and biochemical criteria, although the organisms did not appear to correspond to any species with a validly published name. Comparative 16S rRNA gene sequencing confirmed their identification as members of the genus Streptococcus, being most closely related phylogenetically to Streptococcus porcorum 682-03(T) (96.9% 16S rRNA gene sequence similarity). Analysis of rpoB and sodA gene sequences showed divergence values between the novel species and S. porcorum 682-03(T) (the closest phylogenetic relative determined from 16S rRNA gene sequences) of 18.1 and 23.9%, respectively. The novel bacterial isolate could be distinguished from the type strain of S. porcorum by several biochemical characteristics, such as the production of glycyl-tryptophan arylamidase and α-chymotrypsin, and the non-acidification of different sugars. Based on both phenotypic and phylogenetic findings, it is proposed that the unknown bacterium be assigned to a novel species of the genus Streptococcus, and named Streptococcus pharyngis sp. nov. The type strain is DICM10-00796B(T) ( = CECT 8754(T) = CCUG 66496(T)).

  2. Macrosomic Neonates Carry Increased Risk of Dental Caries in Early Childhood: Findings from a Cohort Study, the Okinawa Child Health Study, Japan.

    Science.gov (United States)

    Yokomichi, Hiroshi; Tanaka, Taichiro; Suzuki, Kohta; Akiyama, Tomoki; Yamagata, Zentaro

    2015-01-01

    Although many studies have discussed health risks in neonates with a low birth weight, few studies have focused on the risks in neonates with a high birth weight. The objective of this study was to determine whether differences in the incidence of dental caries in early childhood are associated with birth weight status. A total of 117,175 children born in Okinawa Prefecture, Japan from 1997 to 2007 were included in this study. Medical professionals collected information about birth records, growth and development, parental child-rearing practices and dental health at 3 months, 18 months and 3 years of age. The risk of dental caries among neonates with macrosomia (birth weight ≥4000 g) was compared with that among neonates with normal weight (2500-3999 g). Sensitivity analyses included 'large for gestational age' (LGA, birth weight above the 90th percentile for gestational age), which was relative to 'appropriate for gestational age' (birth weight between 10th and 90th percentiles). Relative risks and relative risk increases were estimated by multivariate Poisson regression. At 3 years of age, the relative risk increases for dental caries after adjusting for confounding factors were 19% [95% confidence interval (CI), 11%-28%, P < 0.001] for macrosomic neonates and 12% (95% CI, 9%-16%, P < 0.001) for LGA neonates. Macrosomia and LGA were associated with an increased risk of dental caries in early childhood. Particular attention should be paid to abnormally large neonates.

  3. Organometallic Ru(II) Photosensitizers Derived from π-Expansive Cyclometalating Ligands: Surprising Theranostic PDT Effects.

    Science.gov (United States)

    Sainuddin, Tariq; McCain, Julia; Pinto, Mitch; Yin, Huimin; Gibson, Jordan; Hetu, Marc; McFarland, Sherri A

    2016-01-04

    The purpose of the present study was to investigate the influence of π-expansive cyclometalating ligands on the photophysical and photobiological properties of organometallic Ru(II) compounds. Four compounds with increasing π conjugation on the cyclometalating ligand were prepared, and their structures were confirmed by HPLC, 1D and 2D (1)H NMR, and mass spectrometry. The properties of these compounds differed substantially from their Ru(II) polypyridyl counterparts. Namely, they were characterized by red-shifted absorption, very weak to no room temperature phosphorescence, extremely short phosphorescence state lifetimes ( 300 μM) but was phototoxic to cells in the nanomolar regime. Exceptionally large phototherapeutic margins, exceeding 3 orders of magnitude in some cases, were accompanied by bright ligand-centered intracellular fluorescence in cancer cells. Thus, Ru(II) organometallic systems derived from π-expansive cyclometalating ligands, such 4,9,16-triazadibenzo[a,c]napthacene (pbpn), represent the first class of potent light-responsive Ru(II) cyclometalating agents with theranostic potential.

  4. Reliability and validity of Yo-Yo tests in 9- to 16-year-old football players and matched non-sports active schoolboys

    DEFF Research Database (Denmark)

    Póvoas, Susana C A; Castagna, Carlo; Soares, José M C

    2016-01-01

    The purpose of this study was to examine the test-retest reliability and construct validity of three age-adapted Yo-Yo intermittent tests in football players aged 9-16 years (n = 70) and in age-matched non-sports active boys (n = 72). Within 7 days, each participant performed two repetitions...... performances and HRpeak are reliable for 9- to 16-year-old footballers and non-sports active boys. Additionally, performances of the three Yo-Yo tests were seemingly better for football-trained than for non-sports active boys, providing evidence of construct validity....... of an age-related intensity-adapted Yo-Yo intermittent test, i.e. the Yo-Yo intermittent recovery level 1 children's test for 9- to 11-year-olds; the Yo-Yo intermittent endurance level 1 for 12- to 13-year-olds and the Yo-Yo intermittent endurance level 2 test for 14- to 16-year-olds. Peak heart rate...

  5. Voicing Ageism in Nursing Home Dementia Care.

    Science.gov (United States)

    Williams, Kristine; Shaw, Clarissa; Lee, Alexandria; Kim, Sohyun; Dinneen, Emma; Turk, Margaret; Jao, Ying-Ling; Liu, Wen

    2017-09-01

    Elderspeak (i.e., infantilizing communication) is a common form of ageism that has been linked to resistiveness to care in nursing home residents with dementia. Nursing home staff use elderspeak by modifying speech with older residents based on negative stereotypes, which results in patronizing communication that provides a message of incompetence. The purpose of the current secondary analysis was to describe communication practices used by nursing home staff that reflect ageism. Transcripts of 80 video recordings of staff-resident communication collected during nursing home care activities were re-analyzed to identify specific elderspeak patterns, including diminutives, collective pronouns, tag questions, and reflectives. Elderspeak was used in 84% of transcripts, and specifically during bathing, dressing, oral care, and other activities. Collective pronoun substitution occurred most frequently-in 69% of recorded conversations. Subgroup analysis of the inappropriate terms of endearment found that "honey"/"hon" and "sweetheart"/"sweetie" were most commonly used. [Journal of Gerontological Nursing, 43(9), 16-20.]. Copyright 2017, SLACK Incorporated.

  6. Atividade residual in vitro do pelo de cobertura de cães tratados com dinotefuran sobre larvas e adultos de Ctenocephalides felis felis (Bouché, 1835 (Siphonaptera: pulicidae Residual activity in vitro of treated dog's hair coat with dinotefuran on larvae and adults of Ctenocephalides felis felis (Bouché, 1835 (Siphonaptera: Pulicidae

    Directory of Open Access Journals (Sweden)

    Thaís R. Correia

    2008-12-01

    Full Text Available O objetivo deste trabalho foi avaliar a atividade in vitro do resíduo em pelo de cobertura de cães tratados com dinotefuran sobre larvas e adultos de Ctenocephalides felis felis. Foram utilizadas três cadelas da Raça Beagle: a nº 1 foi tratada com uma formulação spray de dinotefuran a 0,834%, a nº 2 com uma formulação "strip-on" de dinotefuran a 30% e a nº 3 foi mantida sem tratamento. Pequenas áreas foram tricotomizadas nos dias 2, 9, 16, 23, 30, 37 e 44 após o tratamento. Para avaliação adulticida e larvicida, foram utilizados pulgas de uma colônia mantida em laboratório. Seis repetições com cada uma contendo 10 exemplares de C. f. felis, acondicionados em tubos de ensaio, da etapa correspondente foram utilizados por dia de desafio. Em cada repetição foi adicionado 0,02 gramas de pelo de cada área tricotomizada e dieta na etapa de larvas. O material da etapa adulto foi avaliado num período de 24 horas, o da etapa larvas foi avaliado após 20 dias de cada desafio. O resíduo no pêlo de cães tratados com ambas as formulações de dinotefuran foi eficaz no controle de larvas por um período de 44 dias, e no controle de adultos as formulações spray e a "strip-on" foram eficazes por um período de 16 e 23 dias, respectivamente.The aim of this study was to evaluate the residual activity of treated dog's hair coat with dinotefuran on larvae and adults of Ctenocephalides felis felis. Three female Beagle dogs were used. One female dog was treated with 0.834% dinotefuran spray, the second was treated with 30% dinotefuran strip-on and the third was not treated. Some areas of dog's hair were clipped on days 2, 9, 16, 23, 30, 37 and 44 after treatment. For the evaluation of adulticidal and larvicidal activities, flea adults and larvae from the laboratory colony were used. Six repetitions were used with 10 samples of each flea stage per day, placed in assay tubes. In each repetition we added 0.02 g of treated or untreated dog

  7. Função sexual de homens submetidos a transplante hepático Sexual function of males subjected to liver transplantation

    Directory of Open Access Journals (Sweden)

    Júlio Cezar Uili Coelho

    2003-01-01

    Full Text Available OBJETIVO: Avaliar a qualidade de vida sexual masculina antes e depois do transplante hepático. MÉTODOS: Foi enviado questionário de avaliação para 56 doentes masculinos, que tinham idade superior a 18 anos e que sobreviveram mais de seis meses após o transplante hepático. O questionário continha 15 perguntas com cinco ou seis alternativas de resposta para mensurar a função sexual masculina segmentada por cinco componentes: função erétil, função orgástica, desejo sexual, satisfação com a relação sexual e satisfação com a vida sexual como um todo. As respostas geraram valores numéricos, os quais foram agrupados dentro de cada domínio e comparados antes e depois do transplante hepático. RESULTADOS: Vinte e cinco doentes responderam completamente o questionário. Todas os cinco componentes da função sexual melhoraram após o transplante hepático, sendo que o escore da função erétil aumentou de 21,12±8,07 para 26,52±5,22 (p=0,004, da função orgástica de 7,28±3,05 para 9,36±1,47 (p=0,008, da função desejo sexual de 6,64±2,58 para 8,68±1,35 (p=0,005, da satisfação com relação sexual de 9,16±3,83 para 12,52±2,65 (pBACKGROUND: Sexual dysfunction is very common in liver transplantation candidates. Our objective is to determine the sexual life quality of males before and after liver transplantation. METHODS: Questionnaire was sent to 56 males over 18 years of age with at least six-month survival after orthotopic liver transplantation. The self-administered questionnaire contained 15 questions with 5 or 6 alternatives to determine the male sexual function which may be divided into 5 domains: 1 erectile function; 2 orgasmic function; 3 sexual desire; 4 intercourse satisfaction; and 5 overall satisfaction with sexual life. Each answer received a score. Domains scores were computed by summing the scores for individual answers and they were compared before and after the liver transplantation. RESULTS: Twenty

  8. Influência da disponibilidade de presas, do contraste visual e do tamanho das larvas de Pantala sp. (Odonata, Insecta sobre a predação de Simocephalus serrulatus (Cladocera, Crustacea Influence of prey availability, visual contrast and size of dragonfly (Pantala sp. larvae (Odonata, Insecta on the predation of Simocephalus serrulatus (Cladocera, Crustacea

    Directory of Open Access Journals (Sweden)

    Anna Christina Esper Amaro de Faria

    2001-05-01

    Full Text Available Objetivou-se avaliar a influência da disponibilidade de presas, do contraste visual e do tamanho das larvas de Odonata (Pantala sp. sobre a predação de cladóceros (Simocephalus serrulatus. Para estudar a taxa de predação em função da disponibilidade de cladóceros em contraste visual, foram utilizadas 24 larvas de Odonata (12,57±0,05 mm e 100,01±9,16 mg. Foram utilizados 5, 10, 15 20 cladóceros/litro, em aquários de vidro transparente (1-L, e as mesmas densidades em aquários revestidos por plástico preto. Os cladóceros (1,63±0,21 mm e 0,78 mg foram contados e repostos a cada hora, por cinco horas consecutivas. Para estudar o efeito do tamanho de larvas de Odonata na predação de cladóceros, foram utilizadas 24 larvas de diferentes tamanhos, as quais foram colocadas em recipientes (50-ml. Colocaram-se 20 cladóceros com cada larva, realizando-se contagem e reposição dos indivíduos consumidos, a cada dez minutos, por duas horas consecutivas. Observou-se efeito quadrático (p The influence of prey availability, visual contrast and size of dragonfly (Pantala sp larvae on the predation of cladocerans (Simocephalus serrulatus is provided. Twenty-four dragonfly naiads (12.57±0.05 mm and 100.01±9.16 mg were employed to study the relation between predation rate and availability of cladocerans and visual contrast. 5,10, 15 and 20 cladocerans/L were placed in 1L transparent and black plastic lined aquariums. Cladocerans (1.63±0.21 mm and 0.78 mg were counted and replaced hourly for five consecutive hours. Twenty-four naiads of different sizes were placed in 50mL recipients to study effects of size of dragonfly larvae. Each larvae received 20 cladocerans; counting and reposition of individuals consumed every ten minutes during two consecutive hours were undertaken. Quadratic effect (p < 0.02 in predation rate was reported, with an increase in prey availability: 21.67; 39.00; 42.44 and 49.67% were reported for densities of 5, 10, 15

  9. Perfil de sensibilidade antimicrobiana e detecção do gene ISS pela reação em cadeia da polimerase na tipificação de Escherichia coli patogênica em codornas de corte sob inspeção sanitária Profile of antimicrobial resistance and detection of iss gene by the polymerase chain reaction in the typification of pathogenic Escherichia coli in meat type quails under sanitary inspection

    Directory of Open Access Journals (Sweden)

    Dayse Lima da Costa Abreu

    2010-05-01

    Full Text Available A patogenicidade das cepas de Escherichia coli está relacionada à expressão de fatores de virulência encontrados em elementos genéticos denominados plasmídios. O patotipo APEC, responsável por diferentes tipos de doenças em aves, pode apresentar o gene iss que aumenta a resistência das cepas de E. coli aos efeitos líticos do soro, além da resistência a diversos antimicrobianos. Este estudo foi conduzido para detectar E. coli em traquéias de codornas destinadas ao abate e avaliar, pela presença do gene iss e o perfil de susceptibilidade antimicrobiana, o potencial patogênico para aves e humanos dos isolados obtidos. Foram coletadas 180 traquéias de codornas para detecção de E. coli, determinação do perfil de resistência a agentes antimicrobianos e posterior detecção, por reação em cadeia da polimerase (PCR, do gene iss. Das traquéias analisadas, 8,9 % (16/180 foram positivas para E. coli, sendo obtidos 20 isolados deste agente. A maioria dos isolados foi resistente à Tetraciclina (16/20, seguida pela Ceftazidima (13/20 e Ácido Nalidíxico (12/20, sendo apenas um resistente à Amoxicilina. A detecção do gene iss ocorreu em 55% (11/20 dos isolados. A presença do gene iss e a resistência a múltiplos antimicrobianos dos isolados obtidos neste estudo pode indicar um possível potencial patogênico das cepas de E. coli tanto para codornas quanto para outros tipos de aves e animais e mesmo para o ser humano que fique em contato com as mesmas.The pathogenicity of Escherichia coli strains is partially related to the expression of virulence factors genes, present in genetic elements called plasmids. APEC strains responsible for diseases in birds may present the iss gene which increases the resistance of E. coli strains to the lityc effect of the host's serum, besides resistance to several antimicrobials. This study was conduced in order to detect E. coli in tracheae of meat-type quails and to evaluate, by the presence of

  10. Caracterização da estrutura anatômica, densidade básica e morfologia de cavacos da madeira de Eucalyptus grandis para a produção de painéis MDF Characterization of wood anatomy, basic density, and morphology of Eucalyptus grandis chips for MDF production

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    Ugo Leandro Belini

    2008-08-01

    Full Text Available O aumento na produção dos painéis "Medium Density Fiberboard" (MDF confeccionados com madeira de espécies de Eucalyptus spp de rápido crescimento evidencia a necessidade da caracterização dos seus componentes celulares, da densidade básica e da morfologia de cavacos. Com esse objetivo, foram coletadas três amostras de cavacos de madeira de árvores de Eucalyptus grandis, na linha de produção de indústria de painel. Em laboratório, os cavacos foram dissociados por maceração, para a avaliação das dimensões das fibras e dos vasos; determinou-se a densidade básica dos cavacos, bem como se caracterizaram a sua espessura e morfologia. Os resultados indicaram valores médios de 1005-19,7-11,8-3,9 µm para o comprimento, largura, diâmetro do lume e espessura média da parede das fibras, respectivamente. A densidade básica da madeira foi de 0,432 g/cm³ e a espessura dos cavacos, de 4,36 mm. Os valores médios de retenção dos cavacos foram de 0,9-16,9-44,5-30,7-6,1-0,9% nas peneiras 40, 25, 16, 8, 3,35 mm e fundo, respectivamente, sendo 75,2% retidos nas peneiras de 16-8 mm de abertura. Os resultados das análises anatômicas e morfológicas dos cavacos de madeira foram discutidos e comparados com informações da literatura especializada e correlacionados com o processo produtivo de chapas MDF.The increase of the MDF panels (Medium Density Fiberboard production by the use of the fast growing eucalypt wood species it evidences the need of the characterization of the cellular components, basic density and the chips morphology. With this aim 3 samples of wood chips of Eucalyptus grandis trees were collected, in the production line of panel industry. In laboratory, the wood chips were dissociated by maceration for the evaluation of the fiber and vessels dimensions; the wood basic density was determined and the thickness and morphology were characterized. The results indicated mean values of 1005-19,7-11,8-3,9 µm for the fiber length

  11. Una nueva especie de pez del género Bryconamericus (Ostariophysi: Characidae del río Magdalena, con una clave para las especies de Colombia

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    César Román-Valencia

    2008-12-01

    Full Text Available Con base en una serie de 90 ejemplares, en caracteres morfométricos, merísticos y osteología, se describe una nueva especie de Bryconamericus de la Quebrada La Pontesuela, boca de la quebrada Coclina, cuenca media del río Magdalena en Colombia. Se utiliza un gráfico de cajas con intervalos de confianza al 99% para ilustrar la medida merística que mostrara menor solapamiento y distinguiera parcialmente al nuevo taxon de las otras especies del río Magdalena. La especie se distingue de sus congéneres por el mayor número de escamas: sobre la línea lateral (50-54 vs. 30-50, excepto B. terrabensis con 47-54 escamas, entre la línea lateral y el origen de la aleta dorsal (9-11 vs. 4-9, entre la línea lateral y el origen de las aletas pélvicas (8-10 vs. 2-8, entre la línea lateral y el origen de la aleta anal (8-10 vs. 2-8 excepto B. terrabensis con 6-9 y predorsales (16-18 vs. 9-16, excepto B. huilae con 14-19 escamas, B. galvisi con 12 a 17 y B. tolimae con 13-17.A new species of fish of the genus Bryconamericus (Ostariophysi: Characidae from the Magdalena river, with a key to Colombian species. Based on a series of 90 specimens, and using morphometric, meristic and osteological characters, a new species of the genus Bryconamericus is described from Pontesuela Creek at the mouth of Coclina Creek in the middle Magdalena river Basin of Colombia. We use box graphs with 99% confidence intervals to illustrate the extent of meristic character overlap and to help distinguish this new taxon from other species of the Magdalena River. The species can be distinguished from all congeners by the combination of the following characters: the higher number of lateral line scales (50-54 vs. 30-50, except B. terrabensis with 47-54; more scales between the lateral line and the dorsal fin origin (9-11 vs. 4-9; more scales between the lateral line and the pelvic fin origin (8-10 vs. 2-8; more scales between lateral line and anal fin origin (8-10 vs. 2

  12. Qualidade de queijo minas frescal preparado com leite com diferentes quantidades de células somáticas Quality of minas frescal cheese prepared from milk with different somatic cell counts

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    Evelise Andreatta

    2009-03-01

    Full Text Available The objective of this work was to evaluate the effects of using bulk milk with different somatic cell counts (SCC on the quality of minas frescal cheese. A randomized complete block design was used, with 3x5 factorial treatments, with three SCC levels (low, 125,000 cells mL-1; intermediate, 437,000 cells mL-1; and high, 1,053,000 cells mL-1 and five storage durations. Cheese was vacuum-packed in plastic bags and analyzed after 2, 9, 16, 23 and 30 days of storage at 4ºC. Somatic cell counts did not affect dry matter, fat, ash content, pH, free fatty acid concentrations and sensory parameters of minas frescal cheese. However, SCC in milk increased losses of protein in whey and decreased the cheese protein content. These changes did not affect the moisture-adjusted cheese yield and proteolysis during 30 days of storage. An interaction effect between SCC and time of storage was observed for firmness and sensory grades of cheeses. Results indicated that raw milk used to produce minas frescal cheese should not contain high SCC, in order to avoid lower acceptance of the product after 30 days of storage.O objetivo deste trabalho foi avaliar o efeito do uso de leite com diferentes contagens de células somáticas (CCS, na qualidade do queijo minas frescal. Utilizou-se delineamento de blocos ao acaso, em esquema fatorial 3x5, com três níveis de CCS (baixa, 125.000 células mL-1; intermediária, 437.000 células mL-1; e alta, 1.053.000 células·mL-1 e cinco tempos de armazenamento. Os queijos foram embalados a vácuo, em embalagens de plástico, e analisados após 2, 9, 16, 23 e 30 dias de armazenamento a 4ºC. A contagem de células somáticas não afetou a matéria seca, a gordura, as cinzas, o pH, a concentração de ácidos graxos livres e os parâmetros sensoriais do minas frescal. A CCS no leite aumentou as perdas de proteína no soro e diminuiu o teor de proteína no queijo. Essas alterações não afetaram o rendimento com umidade ajustada e a

  13. Risk factors for avascular osteonecrosis in children with malignant tumors after thermochemotherapy

    International Nuclear Information System (INIS)

    Balzer, S.; Wessalowski, R.; Mils, O.; Schneider, D.; Bernbeck, B.; Goebel, U.; Jaeger, M.; Krauspe, R.

    2005-01-01

    following groups: 1-8 sessions (32 pts), 9-16 sessions (34 pts), > 16 sessions (3 pts). Power supply per body weight was classified into four distinct groups: 1-10 W/kg (6 pts), 10 to 100 min (3 pts), 50-100 min (2 pts), 20-50 min (6 pts), 10-20 min (18 pts), ≤10 min (41 pts). Severity of ON was defined: slight, moderate and severe. Seven out of 72 patients treated with RHT and chemotherapy ± radiotherapy developed ON, 1/7 double-sided. Appearance of aseptic ON is related to young age (5/7 pts 15 years), high power supply per body weight (2/7 pts 10-20 W/kg, 5/7 pts 20-30 W/kg) and high number of heat sessions (6/7 pts 9-16 sessions, 1/7 pts > 16 sessions). The present analysis showed that aseptic On can be a complication of RHT treatment in children and adolescents, which is not observed in adults. Pain or other skeletal symptoms after power supply of >20 W/kg body weight disclose a risk of osteochondrosis in young patients. We speculate that heat-induced reduction of blood perfusion and chondral injuries of the hip may be relevant for this specific complication in the pediatric age group. In the future 3D temperature measurement by MRI may be helpful to avoid dangerous temperatures in normal tissues. (author)

  14. Teores de colesterol, lipídios totais e ácidos graxos em cortes de carne suína Cholesterol, total lipds and fatty acids in cuts of pork

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    Neura Bragagnolo

    2002-01-01

    Full Text Available A carne suína é um alimento considerado rico em colesterol, lipídios e ácidos graxos saturados. De acordo com a AMERICAN HEART ASSOCIATION, para manter baixos níveis de colesterol sangüíneo, a alimentação deve ser pobre em colesterol e lipídios, principalmente gordura saturada. No presente trabalho foram determinados os teores de colesterol, lipídios totais e ácidos graxos em lombo, pernil, paleta e toucinho, comercializados em açougues da cidade de Campinas, São Paulo. Foi verificado também o efeito da inclusão da gordura externa nos níveis destes componentes. O teor médio de lipídios totais foi de 3 a 5g/100g nos cortes de carne e 83g/100g no toucinho. O colesterol variou, em média, de 42 a 53mg/100g, sendo menor no lombo e maior no toucinho. Não houve diferença significativa (p³0,05 no nível de colesterol entre lombo com e sem gordura externa. Em todos os cortes e no toucinho, foram identificados trinta e seis (36 ácidos graxos, os principais dos quais foram: 18:1ômega9, 16:0, 18:2ômega6, 18:0, 16:1ômega7 e 18:1ômega7. O total de ácidos graxos saturados, monoinsaturados e poliinsaturados variou de 33 a 41%, 42 a 48% e 11 a 25%, respectivamente.Pork is a food considered to be rich in cholesterol, lipids and saturated fatty acids. According to the American Heart Association, the diet must be low in cholesterol and lipids, especially saturated fat. In the present work, total lipids, cholesterol and fatty acids were determined in pork loin, fresh ham, pork shoulder and backfat, commercialized in butchery of Campinas City, São Paulo State, Brazil. The mean total lipids was 3 to 5g/100g in the meat cuts and 83g/100g in backfat. Cholesterol varied, on the average, from 42 to 53mg/100g, being lower in pork loin and higher in backfat. No significant difference (p³0,05 in cholesterol content was seen in pork loin with or without external fat. Thirty-six fatty acids were identified in all cuts and the backfat, with

  15. Niveles sanguíneos de plomo en neonatos hijos de madres consumidoras de "basuco": estudio comparativo

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    Martha Piedad Restrepo

    1988-02-01

    Full Text Available

    Obtention of cocaine clorhydrate from coca leaves requires the use of gasoline; therefore residues such as lead may remain in the base paste (basuca; the latter is smoked, under the name basuco, mixed with tobacco or marijuana; It is conceivable that the smoker takes up lead residues that Increase lead blood levels; we wanted to determine whether the use of basuco during pregnancy could produce such effect In the newborn infant. Serum lead concentrations were measured In 19 newborn children and In 18 of their mothers. The latter were basuco consumers. They were compared to those of 20 non consuming delivering women along with 19 of their newborn Infants. Measurements were performed on a Perkin-Palmer model 2380 atomic absorption

    spectrophotometer. Women were divided in four groups according to the degree of consumption, as follows: mild, moderate, Intense or non existent. Mean levels and SDs in the children were respectively: 13.5 ± 9.4; 15.8 ± 6.5; 16.6 ± 7.8; 6.9 ± 5.0 ug/dl; and In their mothers: 13.3 ± 4.6; 13.5 ± 6.9; 16.2 ± 4.9; 8.4 ± 4.6 ug/dl Statistic analysis revealed highly significant differences between mothers and children exposed to basuco and those that were not exposed. No difference was observed ac. cording to the degree of consumption. In conclusion: newborn from basuco consuming mothers have Increased lead blood levels; the long term effects of such alteration should be the subject of further studies.

    La obtención del clorhidrato de cocaína a partir de la hoja de coca requiere el uso de gasolina; residuos de ésta pueden permanecer en la pasta base (basuca; al fumar ésta, mezclada con cigarrillo o marihuana (basuco el consumidor puede captar residuos de plomo e Incrementar sus concentraciones sanguíneas del mismo; quisimos saber si el uso del basuco

  16. Prevalencia del intento de interrumpir el embarazo y factores asociados en una comunidad urbano marginal de Lima-Perú, 2006 Prevalence of the attempts to stop pregnancy and associated factors in a marginal suburban comunnity in Lima-Peru, 2006

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    Carolina Tarqui-Mamani

    2010-03-01

    Full Text Available Objetivos. Estimar la prevalencia y determinar los factores asociados al intento de interrumpir el embarazo en mujeres con antecedente de embarazo. Material y métodos. Se realizó un estudio transversal durante el año 2006. La muestra incluyó a 1057 mujeres con antecedente de embarazo que habitaban en Pamplona Alta, seleccionadas a través del muestreo probabilístico sistemático. Se realizó análisis estadístico descriptivo e inferencial, incluyendo un modelo de regresión logística. Resultados. La prevalencia de la intención de interrumpir su embarazo fue 13,9% (IC99%: 11,1- 16,7. Al efectuarse un análisis multivariado, se encontró que los factores asociados fueron: embarazo no deseado (OR=5,7; IC: 1,9-16,7, la falta de atención prenatal (OR=4,7; IC: 1,8-12,2, la prostitución (OR=11,4; IC: 1,5-87,9, tener menos de 20 años (OR=2,9; IC: 1,1-7,9 y tener más de dos parejas (OR=3,3; IC: 1,1-10,2. Conclusiones. La prevalencia estimada del intento de interrumpir el embarazo en mujeres con antecedente de embarazo en una zona urbano marginal de Lima es baja si se compara al estimado nacional de abortos. Los factores asociados al intento de interrumpir el embarazo son: el embarazo no deseado, prostitución, tener menos de 20 años, tener más de dos parejas y la falta de atención prenatal.Objectives. To estimate the prevalence for the attempts to stop pregnancy among women with history of previous pregnancies, and to determine the factors associated. Material and methods. A cross-sectional study was performed during 2006. Samples included 1057 women with background of pregnancy, living in Pamplona Alta, selected by a systematic random sampling. We applied descriptive and inferential statistics, including a logistic regression model. Results. The prevalence for the attempt to stop pregnancy was 13.9% (99% CI: 11.1-16.7. The factors associated identified by multivariate analysis were: Unwanted pregnancy (OR=5.7; CI: 1.9-16.7, lack of pre

  17. Avaliação de modelos de predição da energia metabolizável do milho para suínos Evaluating models to predict the metabolizable energy of maize for swine

    Directory of Open Access Journals (Sweden)

    R.N. Pelizzeri

    2013-04-01

    Full Text Available Os objetivos propostos no presente trabalho foram a validação da predição de modelos de regressão linear de 1º grau, dos valores estimados de energia metabolizável (EM em função dos valores observados de EM do milho, obtidos em ensaios biológicos com suínos. Setenta e quatro registros de composição química e energética do milho foram obtidos na literatura e utilizados para estimar a EM de 41 modelos de predição em função da composição química. A significância dos parâmetros (β0 e β1 da regressão foi avaliada pelo teste t parcial, e a validação da predição dos modelos de 1º grau foi obtida pela aceitação da hipótese de nulidade conjunta β0=0 e β1=1. Os modelos EM7 = 1,099 + 0,740EB - 5,5MM - 3,7FDN; EM9 = 16,13 - 9,5FDN + 16EE + 23PB*FDN - 138MM*FDN e EM13 = 5,42 - 17,2FDN - 19,4MM + 0,709EB são os mais adequados para estimar os valores de EM do milho e podem ser utilizados como ferramenta para formulação de rações para suínos.The proposed objective of this study was to validate the prediction of linear regression models of the first degree, the estimated values of metabolizable energy (ME regarding the observed ME values of maize obtained in biological assays with swine. Seventy four records of chemical and energetic composition of maize were obtained from literature and used to estimate the ME of 41 prediction models depending on the chemical composition. The significance of the regression parameters (β0and β1was evaluated by partial t test and the prediction validation of first degree models was obtained by accepting the null hypothesis β0=0 and β1=1. The ME7= 1.099 + 0.740GE - 5.5MM - 3.7NDF; ME9= 16.13 - 9.5NDF + 16EE + 23CP*NDF - 138MM* NDF and ME13= 5.42 - 17.2 NDF - 19.4MM + 0.709GE models are the most adequate to estimate the metabolizable energy of maize and can be used as a tool to formulate diets for swine.

  18. Conteúdo e exportação de micronutrientes em acácia-negra (Acacia Mearnsii De Wild. procedência batemans bay (Austrália Content and exportation of micronutrients in black wattle (Acacia Mearnsii de wild. of Australian batemans bay provenance

    Directory of Open Access Journals (Sweden)

    Marcos Vinicius Winckler Caldeira

    2003-02-01

    Full Text Available O objetivo do presente trabalho foi estimar o conteúdo e a exportação de micronutrientes (Mn, B, Cu, Zn e Fe e o Na nos diferentes componentes de árvores de um povoamento de acácia-negra (Acacia mearnsii De Wild., procedência australiana Batemans Bay, com 2,4 anos de idade, em Butiá-RS (Brasil. A biomassa total estimada foi de 36.155 kg/ha, apresentando distribuição de 46,0, 20,0, 19,5, 12,0 e 3,0%, na madeira do lenho, nas folhas, nos galhos vivos, na casca e nos galhos mortos, respectivamente. A proporção de micronutrientes acumulados na biomassa dos componentes da árvore foram 43,76% nas folhas, 26,94% na madeira do tronco, 19,56% nos galhos vivos, 7,21% na casca e 2,54% nos galhos mortos. A quantidade estimada de micronutrientes contidos na biomassa acima do solo foi 10,4 kg/ha, acumulados da seguinte forma: Na (58,84%, Fe (21,79%, Zn (9,16%, B (4,09%, Mn (4,59% e Cu (1,54%. A casca e a madeira do lenho acumulou Na (21,47%, Fe (6,71%, Mn (2,11%, Zn (1,66%, B (1,58% e Cu (0,63%. A copa (folhas e galhos vivos e mortos acumularam Na (37,36%, Fe (15,07%, Zn (7,49%, B (2,53%, Mn (2,48% e Cu (0,91%. A exploração intensiva de áreas com a procedência Batemans Bay gera suspeitas de possíveis ocorrências de deficiências nutricionais de Na nas rotações futuras, tornando necessário o emprego de fertilizantes para manter a produtividade do sítio.This study aimed to estimate the content and exportation of micronutrients (Mn, B, Cu, Zn e Fe and Na in different tree components of black wattle (Acacia mearnsii De Wild. forest of Batemans Bay Australian provenance, 2.4 years old in Butiá, RS, Brazil. The total biomass found was 36,155 kg/ha, thus distributed: 46.0%; 20.0%; 19.5%; 12.0% and 3.0%, spread in the wood of the stem, leaves, live branches, bark and dead branches, respectively. The proportion of the micronutrients accumulated in the biomass of the components were: leaves (43.76%, wood of the stem (26.94%, live branches (19

  19. Avaliação de poluentes aéreos em instalações de creche e terminação de suínos Evaluation of aerial pollutants in nursery and finishing swine housing

    Directory of Open Access Journals (Sweden)

    Carlos Augusto de Paiva Sampaio

    2007-04-01

    Full Text Available Esta pesquisa foi desenvolvida em duas instalações para suínos nas fases de creche e terminação, em duas salas cada, em granjas localizadas no município de Salto, SP, com os objetivos de avaliar a concentração de amônia e poeira e a presença de fungos, além de estimar os riscos de exposição ocupacional a esses agentes ambientais. As avaliações foram realizadas conforme preceituam as normas NR-15, NIOSH e ACGIH. Os resultados indicaram diferença significativa nas concentrações de amônia em relação aos horários, às instalações e aos períodos do dia. Estes também indicam negligência para a questão da ventilação sanitária nas instalações de creche, com conseqüentes teores mais altos de amônia, e que estes estão vinculados à circulação de ar no interior das instalações, ao manejo dos dejetos e da cortina, à tipologia da construção e às condições de clima local, além da lotação e da densidade de suínos. A concentração de poeira total foi mais alta nos prédios de creche (0,84-9,16mg m-3 do que nos de terminação (0,84-3,34mg m-3, enquanto que a poeira respirável foi mais alta na creche, ficando inferior a 3,67mg m-3 e dentro dos limites de insalubridade para o trabalhador. Foram encontrados fungos do gênero Aspergillus, Penicillium e Neurospora em suspensão no ambiente interno das instalações estudadas.This research was developed in two swine housings in the phases of nursery and finishing: in two pens each, in two farms located at Salto County, SP, with the objective to evaluate ammonia and concentrations, and fungi presence besides estimating the occupational risk of exposure to these environmental agents. The evaluations were done according to recommended by the norms NR-15, NIOSH e ACGIH. Results indicated significant difference in ammonia concentration in relation to the hour, the housing and to the day period. They also indicate negligence to sanitary ventilation matter in nursery

  20. Does mean heart dose sufficiently reflect coronary artery exposure in left-sided breast cancer radiotherapy. Influence of respiratory gating

    Energy Technology Data Exchange (ETDEWEB)

    Becker-Schiebe, Martina [Klinikum Braunschweig, Department of Radiotherapy and Radio-Oncology, Braunschweig (Germany); Hannover Medical School, Radiation Oncology, Hannover (Germany); Stockhammer, Maxi; Franz, Heiko [Klinikum Braunschweig, Department of Gynecology and Obstetrics, Braunschweig (Germany); Hoffmann, Wolfgang; Wetzel, Fabian [Klinikum Braunschweig, Department of Radiotherapy and Radio-Oncology, Braunschweig (Germany)

    2016-09-15

    With extensive use of systemic treatment, the issue of cardiac mortality after breast cancer radiation (RT) is still important. The aim of our analysis was to clarify whether the dose to one surrogate parameter (e. g., mean heart dose, as used in most studies) reflects the dose to the other cardiovascular structures especially the left anterior descending artery depending on breathing-adapted RT. A total of 130 patients who underwent adjuvant RT (50.4 Gy plus boost 9-16 Gy) were evaluated. In all, 71 patients were treated with free-breathing and 59 patients using respiratory monitoring (gated RT). Dosimetric associations were calculated. The mean dose to the heart (Dmean heart) was reduced from 2.7 (0.8-5.2) Gy to 2.4 (1.1-4.6) Gy, the Dmean LAD (left anterior descending artery) decreased from 11.1 (1.3-28.6) Gy to 9.3 (2.2-19.9) Gy with gated RT (p = 0.04). A significant relationship was shown for Dmean{sub heart}-Dmean LAD, V25heart-Dmean LAD and Dmax heart-Dmax LAD for gated patients only (p < 0.01). For every 1 Gy increase in Dmean heart, mean LAD doses rose by 3.6 Gy, without gating V25 ≤5 % did not assure a benefit and resulted in Dmean LAD between 1.3 and 28.6 Gy. A significant reduction and association of heart and coronary artery (LAD) doses using inspiratory gating was shown. However, in free-breathing plans commonly measured dose constraints do not allow precise estimation of the dose to the coronary arteries. (orig.) [German] Das Risiko kardialer Spaetfolgen nach Bestrahlung (RT) eines Mammakarzinoms spielt insbesondere auch aufgrund der zunehmenden systemischen Begleittherapien eine wichtige Rolle. Unklar ist, welche koronaren und/oder myokardialen Mechanismen hier entscheidend sind. Der Einfluss der Atemtriggerung und der daraus resultierenden geometrischen Lagevariabilitaet der Risikoorgane auf die Dosisverteilung am Herzen/Koronarien sollte geprueft werden, um zu klaeren, inwieweit die mittlere Herzdosis ein ausreichender Surrogatparameter fuer

  1. Dental caries and treatment needs among indigenous people of the Potiguara Indian reservation in Brazil Caries dental y necesidades de tratamiento en los indígenas de la reserva india Potiguara de Brasil

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    Fábio Correia Sampaio

    2010-04-01

    Full Text Available OBJETIVE: The aim of this study was to assess the caries prevalence and treatment needs of Brazilian indigenous residents on an Indian reservation. METHODS: This cross-sectional study comprised 1 461 individuals of ages 18-36 months and 5, 12, 15-19, 35-44, and 65-74 years living in the Potiguara Indian villages of Brazil. Decayed, missing, or filled permanent teeth (DMFT and deciduous teeth (dmft were determined by calibrated examiners using the methodology recommended by the World Health Organization. Treatment needs were assessed with the guidelines of the 2003 Brazilian Oral Health Survey. RESULTS: Means ± standard deviations (SD for dmft of 18- to 36-month-old and 5-year-old children were 2.5 ± 3.7 and 5.8 ± 4.3, respectively. For the age groups 12, 15-19, 35-44, and 65-74 years, mean ± SD values of DMFT were 3.6 ± 3.1, 7.1 ± 4.9, 16.4 ± 7.5, and 22.8 ± 8.6. The mean ± SD number of deciduous teeth requiring treatment varied from 2.4 ± 3.5 to 5.0 ± 4.0 in the 18- to 36-month and 5-year-old age groups, respectively. Among adolescents and adults, it was observed that on average at least three permanent teeth required dental treatment such as fillings, crowns, endodontic treatment, and extractions. CONCLUSIONS: High prevalence of caries and many teeth needing treatment were observed in all age groups of the Potiguara Indians.OBJETIVO: El objetivo de este estudio fue evaluar la prevalencia de caries y las necesidades de tratamiento en los residentes indígenas brasileños de una reserva india. MÉTODOS: En este estudio transversal se incluyó a 1 461 personas de 18 a 36 meses de edad, y de 5, 12, 15-19, 35-44, y 65-74 años, que vivían en aldeas indias Potiguara de Brasil. Se determinaron los dientes permanentes cariados, perdidos y obturados (CPO y los dientes deciduos mediante examinadores calibrados, con ayuda del método recomendado por la Organización Mundial de la Salud. Las necesidades de tratamiento se evaluaron con las

  2. Sistema de Suplementação Alimentar para Bovinos de Corte em Pastejo: Simulação A System of Feed Supplementation for Beef Cattle under Grazing: Simulation

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    Rogério de Paula Lana

    2002-02-01

    Full Text Available Objetivou-se com este trabalho demonstrar a aplicação do Sistema Viçosa de Formulação de Rações na recomendação de suplementos alimentares para bovinos de corte com 200 e 400 kg de peso corporal, em diferentes épocas de diferimento e utilização dos pastos. Verificou-se que, para animais com 200 kg de peso corporal ganhar 1 kg/dia no pasto diferido em fevereiro e utilizado em junho ou setembro, ou diferido em abril e utilizado em junho ou setembro, houve necessidade de 2,16; 3,60; 0,50 e 3,23 kg de suplemento/animal/dia, respectivamente. Para animais com 400 kg de peso corporal, a necessidade de suplementação foi ainda maior: 4,21; 5,86; 2,48 e 5,24 kg/animal/dia. O teor de uréia (1,4; 0,9; 9,8 e 0,9; e 5,3; 0,9; 16,5 e 0,4%, respectivamente e o teor e a composição da mistura mineral nos suplementos também variaram muito nessas diferentes situações. O Sistema Viçosa de Formulação de Rações possibilitou formular suplementos específicos para cada situação, de uma maneira rápida e eficiente, com base em equações de estimativas de consumo de suplemento em função do peso corporal do animal e nível de uréia, permitindo formular suplementos apenas para corrigir as deficiências nutricionais ou para se obter ganhos de peso mais elevados.This work aimed to demonstrate the application of a computer system (Sistema Viçosa de Formulação de Rações in the recommendation of feed supplements for beef cattle with 200 and 400 kg of body weight, on different pasture deferring and utilization periods. In order to an animal of 200 kg of body weight achieve 1 kg of daily gain in a pasture deferred in February and used in June or September, or deferred in April and used in June or September, it was necessary 2.16, 3.60, 0.50 and 3.23 kg of supplement/animal/day, respectively. In order to an animal of 400 kg of body weight, the need for supplementation was even greater: 4.21, 5.86, 2.48 and 5.24 kg/animal/day. The urea content (1

  3. Penyimpangan Penggunaan Lahan Berdasarkan Rencana Tata Ruang Wilayah Kabupaten Aceh Barat

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    Hairul Basri

    2013-04-01

    Full Text Available Abstrak. Penelitian ini bertujuan untuk: (1 mengevaluasi kesesuaian alokasi ruang RTRW Kabupaten Aceh Barat tahun 2012- 2031 dengan alokasi penetapan kawasan hutan Kabupaten Aceh Barat berdasarkan SK Menhutbun No. 170/Kpts- II/2000, dan (2 mengevaluasi penyimpangan penggunaan lahan eksisting Kabupaten Aceh Barat tahun 2012 dengan RTRW Kabupaten Aceh Barat tahun 2012-2031 dan (3 membahas secara umum penyebab dari penyimpangan penggunaan lahan dan dampak yang ditimbulkannya. Penelitian ini dilaksanakan dari bulan Maret 2012 hingga Februari 2013 di Kabupaten Aceh Barat dan di Laboratorium Penginderaan Jauh dan Kartografi Fakultas Pertanian Universitas Syiah Kuala. Penelitian ini menggunakan metode deskriptif dengan mengumpulkan berbagai data sekunder dan primer yang diperlukan dan analisis tumpang tindih peta (overlay serta cek lapangan (ground check penggunaan lahan terkini. Hasil penelitian menunjukkan terjadi penyimpangan alokasi ruang RTRW Kabupaten Aceh Barat tahun 2012-2031 terhadap kawasan hutan Kabupaten Aceh Barat yang ditetapkan dalam SK Menhutbun No. 170/Kpts- II/2000 seluas 6.663,45 ha (2,41%. Penggunaan lahan eksisting Kabupaten Aceh Barat tahun 2012 juga menunjukkan terjadi penyimpangan terhadap alokasi ruang RTRW Kabupaten Aceh Barat tahun 2012-2031 yaitu seluas 25.319,21 ha (9,16%. Secara umum faktor penyebab terjadinya penyimpangan penggunaan lahan adalah pemekaran kabupaten/kota, pengembangan infrastruktur wilayah, pengembangan usaha perkebunan dan pertambangan. Penyimpangan penggunaan lahan tersebut berdampak kepada semakin luasnya deforestasi, meningkatnya koefisien limpasan dan frekuensi banjir. Deviation of Land Use Based on Spatial Planning of West Aceh District Abstract. This study aimed to: (1 evaluate the suitability of spatial allocation of space in West Aceh district from 2012 to 2031 with the allocation of forest establishment of West Aceh by Decree of Menhutbun No. 170/Kpts-II/2000, (2 evaluate the deviation of the

  4. Desenvolvimento gonadal do jundiá, Rhamdia quelen (Teleostei, Siluriformes, em viveiros de terra, na região sul do Brasil = Gonadal development of jundiá, Rhamdia quelen (Teleostei, Siluriformes, in earthen ponds in southern Brazil

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    Luciana Ghiraldelli

    2007-10-01

    Full Text Available O presente estudo caracterizou o desenvolvimento gonadal de jundiá até a maturação sexual, quando cultivados em viveiros de terra, visando subsidiar o desenvolvimento de tecnologia de cultivo para esta espécie na região sul do Brasil. Alevinos de jundiá (peso médio 8 ± 3,73 g foram estocados em três viveiros, na densidade de 0,6indivíduos m-2. Catorze indivíduos foram amostrados mensalmente, de setembro de 2001 a outubro de 2002. Os estádios de maturação gonadal foram caracterizados macroscopicamente, e fragmentos de ovários e testículos de alguns exemplares foram fixados em formalina 4% para análise histológica. Foram analisados 118 exemplares: 60 machos e 58 fêmeas. Os machos apresentaram atividade reprodutiva precoce, quandocomparados às fêmeas. Testículos e ovários apresentaram morfologia similar a de outras espécies de Siluriformes. De acordo com a análise microscópica, as gônadas foram classificadas em quatro estádios de desenvolvimento: imaturo, em maturação inicial, em maturação final e maduro. A relação gonadossomática variou de 0,29 a 9,16 para os machose de 0,11 a 13,03 para as fêmeas. Indivíduos maduros foram observados nos meses de verão (dezembro/2001 e janeiro/2002, outono (abril e maio/2002 e primavera (setembro e outubro/2002, acompanhando o aumento de temperatura.The study characterized the gonadal development of jundiá from approximately 8 g until gonadal maturation, to provide further knowledge for farming jundiá in Southern Brazil. Jundiá fingerlings(average weight 8.00 ± 3.73 g were stocked in three ponds at 0.6 fish m-2. Fourteen fish were sampled each month from September 2001 to October 2002. Gonadal maturation stages were characterized macroscopically, and samples of ovaries and testicles were fixedin 4-%-buffered formalin for histological examination. One hundred and eighteen fish were analyzed: 60 males e 58 females. Jundiá males matured earlier than females. Testicles and

  5. Prevalência da doença arterial coronariana em diabéticos tipo 1 candidatos a transplante duplo (rim e pâncreas Prevalence of coronary artery disease in type I diabetic candidates for double transplantation (kidney and pancreas

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    Dinaldo C. Oliveira

    2005-02-01

    Full Text Available OBJETIVO: Avaliar a prevalência da doença arterial coronariana (DAC em população de pacientes diabéticos tipo 1, nefropatas, em programa de diálise e candidatos a transplante duplo (rim e pâncreas. MÉTODOS: De janeiro/2000 a julho/2002, foram submetidos a cinecoronariografia, como protocolo de avaliação para transplante duplo, 58 pacientes diabéticos tipo 1. Doença arterial coronariana foi definida como qualquer irregularidade nas artérias coronárias, e classificada, de acordo com a grau de estenose luminal, em leve (30 a 70% e grave (>70%. RESULTADOS: A idade dos pacientes foi 34 ± 12 anos, sendo que 32 (55% eram homens. Nenhum paciente tinha história de angina ou infarto agudo do miocárdio. Os principais fatores de risco para a doença foram hipertensão arterial sistêmica em 93%, dislipidemia em 38%, historia familiar em 25% e tabagismo 20%. O tempo médio de duração do diabetes foi 20,8 ± 9 anos, o tempo de diálise de 26 ± 9 meses. A coronariografia revelou doença arterial coronariana em 42 (72% pacientes, sendo 20 (34% discreta, 9 (16% moderada e 13 (22% grave. CONCLUSÃO: Pacientes diabéticos tipo 1 em programa de diálise e candidatos a transplante duplo têm elevada prevalência de doença arterial coronariana, tornando-se marcante a observação de que esses pacientes não apresentavam sintomas da doença.OBJECTIVE: To assess the prevalence of coronary artery disease (CAD in a population of type I diabetic, nephropathic patients in a dialysis program and candidates for double transplantation (kidney and pancreas. METHODS: From January 2000 to July 2002, 58 type I diabetic patients underwent coronary cineangiography as part of an assessment protocol for double transplantation. Coronary artery disease was defined as any irregularity in the coronary arteries and was classified according to the degree of luminal stenosis as mild ( 30 to 70%, and severe (> 70%. RESULTS: The mean age of the patients was 34 ± 12 years

  6. The prevalence of waterpipe tobacco smoking among the general and specific populations: a systematic review

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    Aleem Sohaib

    2011-04-01

    Full Text Available Abstract Background The objective of this study was to systematically review the medical literature for the prevalence of waterpipe tobacco use among the general and specific populations. Methods We electronically searched MEDLINE, EMBASE, and the ISI the Web of Science. We selected studies using a two-stage duplicate and independent screening process. We included cohort studies and cross sectional studies assessing the prevalence of use of waterpipe in either the general population or a specific population of interest. Two reviewers used a standardized and pilot tested form to collect data from each eligible study using a duplicate and independent screening process. We stratified the data analysis by country and by age group. The study was not restricted to a specific context. Results Of a total of 38 studies, only 4 were national surveys; the rest assessed specific populations. The highest prevalence of current waterpipe smoking was among school students across countries: the United States, especially among Arab Americans (12%-15% the Arabic Gulf region (9%-16%, Estonia (21%, and Lebanon (25%. Similarly, the prevalence of current waterpipe smoking among university students was high in the Arabic Gulf region (6%, the United Kingdom (8%, the United States (10%, Syria (15%, Lebanon (28%, and Pakistan (33%. The prevalence of current waterpipe smoking among adults was the following: Pakistan (6%, Arabic Gulf region (4%-12%, Australia (11% in Arab speaking adults, Syria (9%-12%, and Lebanon (15%. Group waterpipe smoking was high in Lebanon (5%, and Egypt (11%-15%. In Lebanon, 5%-6% pregnant women reported smoking waterpipe during pregnancy. The studies were all cross-sectional and varied by how they reported waterpipe smoking. Conclusion While very few national surveys have been conducted, the prevalence of waterpipe smoking appears to be alarmingly high among school students and university students in Middle Eastern countries and among groups of

  7. Patterns of locoregional failure following post-operative intensity-modulated radiotherapy to oral cavity cancer: quantitative spatial and dosimetric analysis using a deformable image registration workflow.

    Science.gov (United States)

    Mohamed, Abdallah S R; Wong, Andrew J; Fuller, Clifton D; Kamal, Mona; Gunn, Gary B; Phan, Jack; Morrison, William H; Beadle, Beth M; Skinner, Heath; Lai, Stephen Y; Quinlan-Davidson, Sean R; Belal, Abdelaziz M; El-Gowily, Ahmed G; Frank, Steven J; Rosenthal, David I; Garden, Adam S

    2017-08-15

    We sought to identify spatial/dosimetric patterns of failure for oral cavity cancer patients receiving post-operative IMRT (PO-IMRT). Two hundred eighty-nine OCC patients receiving PO-IMRT were retrospectively reviewed from 2000 to 2012. Diagnostic CT documenting recurrence (rCT) was co-registered with planning CT (pCT) using a validated deformable image registration software. Manually segmented recurrent gross disease (rGTV) was deformed to co-registered pCTs. Mapped rGTVs were compared dosimetrically to planned dose and spatially to planning target volumes using centroid-based approaches. Failures types were classified using combined spatial/dosimetric criteria: A (central high-dose), B (peripheral high-dose), C (central intermediate/low-dose), D (peripheral intermediate/low-dose), and E (extraneous-dose). Fifty-four patients with recurrence were analyzed; 26 local recurrence, 19 regional recurrence, and 9 both local and regional recurrence. Median time to recurrence was 4 months (range 0-71). Median rGTVs volume was 3.7 cm 3 (IQR 1.4-10.6). For spatial and dosimetric analysis of the patterns of failure, 30 patients (55.5%) were classified as type A (central high-dose). Non-central high dose failures were distributed as follows: 2 (3.7%) type B, 10 (18.5%) type C, 1 (1.8%) type D, and 9 (16.7%) type E. Non-IMRT failure in the matching low-neck field was seen in two patients. No failures were noted at the IMRT-supraclavicular field match-line. Approximately half of patients with local/regional failure had non-central high dose recurrence. Peripheral high dose misses were uncommon reflecting adequate delineation and dose delivery. Future strategies are needed to reduce types C and E failures.

  8. A predictive scoring instrument for tuberculosis lost to follow-up outcome

    Science.gov (United States)

    2012-01-01

    Background Adherence to tuberculosis (TB) treatment is troublesome, due to long therapy duration, quick therapeutic response which allows the patient to disregard about the rest of their treatment and the lack of motivation on behalf of the patient for improved. The objective of this study was to develop and validate a scoring system to predict the probability of lost to follow-up outcome in TB patients as a way to identify patients suitable for directly observed treatments (DOT) and other interventions to improve adherence. Methods Two prospective cohorts, were used to develop and validate a logistic regression model. A scoring system was constructed, based on the coefficients of factors associated with a lost to follow-up outcome. The probability of lost to follow-up outcome associated with each score was calculated. Predictions in both cohorts were tested using receiver operating characteristic curves (ROC). Results The best model to predict lost to follow-up outcome included the following characteristics: immigration (1 point value), living alone (1 point) or in an institution (2 points), previous anti-TB treatment (2 points), poor patient understanding (2 points), intravenous drugs use (IDU) (4 points) or unknown IDU status (1 point). Scores of 0, 1, 2, 3, 4 and 5 points were associated with a lost to follow-up probability of 2,2% 5,4% 9,9%, 16,4%, 15%, and 28%, respectively. The ROC curve for the validation group demonstrated a good fit (AUC: 0,67 [95% CI; 0,65-0,70]). Conclusion This model has a good capacity to predict a lost to follow-up outcome. Its use could help TB Programs to determine which patients are good candidates for DOT and other strategies to improve TB treatment adherence. PMID:22938040

  9. Validity of a Minimally Invasive Autopsy for Cause of Death Determination in Adults in Mozambique: An Observational Study.

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    Paola Castillo

    2016-11-01

    Full Text Available There is an urgent need to identify tools able to provide reliable information on the cause of death in low-income regions, since current methods (verbal autopsy, clinical records, and complete autopsies are either inaccurate, not feasible, or poorly accepted. We aimed to compare the performance of a standardized minimally invasive autopsy (MIA approach with that of the gold standard, the complete diagnostic autopsy (CDA, in a series of adults who died at Maputo Central Hospital in Mozambique.In this observational study, coupled MIAs and CDAs were performed in 112 deceased patients. The MIA analyses were done blindly, without knowledge of the clinical data or the results of the CDA. We compared the MIA diagnosis with the CDA diagnosis of cause of death. CDA diagnoses comprised infectious diseases (80; 71.4%, malignant tumors (16; 14.3%, and other diseases, including non-infectious cardiovascular, gastrointestinal, kidney, and lung diseases (16; 14.3%. A MIA diagnosis was obtained in 100/112 (89.2% cases. The overall concordance between the MIA diagnosis and CDA diagnosis was 75.9% (85/112. The concordance was higher for infectious diseases and malignant tumors (63/80 [78.8%] and 13/16 [81.3%], respectively than for other diseases (9/16; 56.2%. The specific microorganisms causing death were identified in the MIA in 62/74 (83.8% of the infectious disease deaths with a recognized cause. The main limitation of the analysis is that both the MIA and the CDA include some degree of expert subjective interpretation.A simple MIA procedure can identify the cause of death in many adult deaths in Mozambique. This tool could have a major role in improving the understanding and surveillance of causes of death in areas where infectious diseases are a common cause of mortality.

  10. A New Estimate of the Power Emitted by Enceladus' Tiger Stripes

    Science.gov (United States)

    Spencer, John R.; Howett, C. J.; Verbiscer, A. J.; Hurford, T. A.; Segura, M.; Spencer, D. C.

    2013-10-01

    The heat flow from the south pole of Enceladus is a fundamental constraint on its tidal dissipation mechanisms, orbital evolution, and the physical processes that generate the plumes. Cassini Composite Infrared Spectrometer (CIRS) observations of the integrated 17 - 1000 micron thermal emission from the south pole have produced an estimated heat flow of 15.8 +/- 3.1 GW (Howett et al. 2011). This is a surprisingly high value, about 10x higher than can be generated by steady-state tidal heating (Meyer and Wisdom 2007). The estimate includes all sources of south polar endogenic emission, but is model-dependent because the observation also includes passive re-radiation of absorbed sunlight, which must be modeled and subtracted from the observed radiation. An alternate approach is to use higher spatial resolution CIRS observations in which emission from the tiger stripes, which is certainly endogenic, is spatially separated from emission from the surrounding terrain, which consists of passive emission plus a possible endogenic component. Tiger stripe emission is thus a lower bound on total endogenic emission, and is itself important as a constraint on plume generation and transport. CIRS has several observations of 9 - 16 micron emission with sufficient resolution to resolve the tiger stripes, but only limited resolved observations at longer wavelengths where most heat is radiated. Combining the best resolved data at all wavelengths, with reasonable assumptions about the ratio of long to short wavelength emission, we obtain preliminary estimates of tiger stripe thermal emission of roughly 4.2 GW, to which must be added ~0.5 GW of plume latent heat (Ingersoll and Pankine 2009), for a total tiger stripe power of about 4.7 GW. We are investigating whether the discrepancy between the new tiger stripe heat flow estimate, and the earlier estimate for the entire south pole, results from a large heat flow component that is not from the tiger stripes, or possible inaccuracies in

  11. Ultrastructure and ssrRNA sequencing of Myxidium amazonense n. sp. a myxosporean parasite of Corydoras melini from the Rio Negro river, Amazonas state, Brazil.

    Science.gov (United States)

    Mathews, Patrick D; Silva, Marcia R M; Maia, Antônio A M; Adriano, Edson A

    2015-12-01

    In a survey of myxozoan parasites of ornamental freshwater fish from the Rio Negro river, it was found that seven of 30 (23.3 %) Corydoras melini specimens examined had plasmodia of a new Myxidium species (Myxidium amazonense n. sp.) in the gallbladder. The fish were caught in the Rio Negro river, in the municipality of Santa Isabel do Rio Negro, in the state of Amazonas, Brazil. The plasmodia had a tubular shape, which was organized as a spiral spring with several turns in the gallbladder. The development of the myxospores was asynchronic, with disporic pansporoblasts. Mature myxospores were elongated, with 17.0 ± 0.9 (16.1-17.9) μm in length and 3.7 ± 0.7 (3.0-4.4) μm in width, and lightly arcuate from the valval view, with their bodies tapering slowly until ending in rounded extremities. The valval surface had nine to ten grooves in each valve. The polar capsules, one at either end of the spore, had a length of 5.4 ± 0.5 (4.9-5.9) μm and a width of 3.4 ± 0.6 (2.8-4.0) μm. Ultrastructural analysis showed that the wall of the plasmodia had numerous microvilli-like structures, pinocytotic canals, and cytoplasmic bridges connecting the pansporoblasts to each other and to the ectoplasm zone. Phylogenetic analysis, based on a small subunit ribosomal RNA (ssrRNA), identified the new species as a sister species of Myxidiumceccarelli, the unique South American Myxidium species whose ssrRNA sequence is available in the NCBI database. This study is the first description of Myxidium species in ornamental freshwater fish from Amazon.

  12. The circumferential resection margins status: A comparison of robotic, laparoscopic and open total mesorectal excision for mid and low rectal cancer.

    Science.gov (United States)

    de Jesus, J P; Valadão, M; de Castro Araujo, R O; Cesar, D; Linhares, E; Iglesias, A C

    2016-06-01

    Minimally invasive surgery for rectal cancer (RC) is now widely performed via the laparoscopic approach, but robotic-assisted surgery may overcome some limitations of laparoscopy in RC treatment. We compared the rate of positive circumferential margins between robotic, laparoscopic and open total mesorectal excision (TME) for RC in our institution. Mid and low rectal adenocarcinoma patients consecutively submitted to robotic surgery were compared to laparoscopic and open approach. From our prospective database, 59 patients underwent robotic-assisted rectal surgery from 2012 to 2015 (RTME group) were compared to our historical control group comprising 200 open TME (OTME group) and 41 laparoscopic TME (LTME group) approaches from July 2008 to February 2012. Primary endpoint was to compare the rate of involved circumferential resection margins (CRM) and the mean CRM between the three groups. Secondary endpoint was to compare the mean number of resected lymph nodes between the three groups. CRM involvement was demonstrated in 20 patients (15.5%) in OTME, 4 (16%) in LTME and 9 (16.4%) in the RTME (p = 0.988). The mean CRM in OTME, LTME and RTME were respectively 0.6 cm (0-2.7), 0.7 cm (0-2.0) and 0.6 cm (0-2.0) (p = 0.960). Overall mean LN harvest was 14 (0-56); 16 (0-52) in OTME, 13 (1-56) in LTME and 10 (0-45) in RTME (p = 0.156). Our results suggest that robotic TME has the same oncological short-term results when compared to the open and laparoscopic technique, and it could be safely offered for the treatment of mid and low rectal cancer. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. People and things. CERN Courier, March 1982, v. 22(2)

    International Nuclear Information System (INIS)

    Anon.

    1982-01-01

    The article reports on achievements of various people, staff changes and position opportunities within the CERN organization and contains news updates on upcoming or past events. From 3-6 May, a 'Workshop on Accelerator Orbit and Particle Tracking Programs' will be held at Brookhaven. The focus will be primarily on computer simulation of non-linear magnetic effects as they influence beam lifetime in storage rings.The 1982 CERN School of Computing will be held from 29 August to 11 September in Zinal, Valais, Switzerland. This will be the seventh such school and will cover topics of current interest in computing which are relevant to data processing needs in high energy physics. This year marks the fiftieth anniversary of the discovery of the neutron by Sir James Chadwick. To commemorate the event, the UK Institute of Physics, in collaboration with the UK Atomic Energy Research Establishment at Harwell, is organizing an international conference at Cambridge from 13-17 September. The layout of the proposed Stanford Linear Collider SLC has been changed for environmental reasons. A workshop on physics with low energy cooled antiprotons at the new LEAR ring, currently under construction at CERN, will be held at Erice, Sicily, from 9-16 May. To stimulate interest in the problems of particle acceleration to the multi-TeV range, ECFA is organizing a meeting to review the limitations and prospects of both conventional and novel particle acceleration techniques. The 1982 CERN School of Physics will take place in Cambridge, UK, from 5-18 September

  14. The image diagnosis of juvenile ankylosing spondylitis

    International Nuclear Information System (INIS)

    Xian Jianxing; Zhao Jihong

    2005-01-01

    Objective: To research the image change of JAS and improve the knowledge of this case. Method: 12 patients in this group, 11 males and 1 female. The morbidity age is between 9-16 years old and in average is 13 years old. All the cases use the pelvis platform and R F, HLA-B27 check. Four of them has made the CT and MRI level. Result: In this group, the case is extended over the sacroiliac joint. Among them, there are 5 samples that are referred to both of the coxa articution. The X-rays shows that under the sacroiliac joint, there has 2/3 sclerotin sclerotized and the side of sacroiliac shows this phenomenon especially. The sacroiliac joint is fuzziness and the size of articulation clearance is different, it shows as the sawtooth. When it refers to the coxa articulation, it shows as the acetabular and at the same time the articulation become abnormally. When it refers to the lumber, it shows as that the lumber articulation fuzziness while the articulation clearance disappear. CT level: when affected with this sickness it show that the size of the clearance is different. MRI level: T 1 WI shows that when affected with this case, it express that the size of the clearance is different and at the side of sacroiliac joint can see the low signal which can change into high signal when put it under the T 2 Wi, HLA-B27 is masculine. Conclusion: Because JAS is lack of the adjust ankylosing spondylitis special clinical in the early stage, so it is always be misdiagnosed as the Juvenile rheumatoid arthritis. In fact they are two different cases and treatment is also different. The authors should improve our knowledge about this case. In our opinion, checking of the image and HLA-B27 can diagnose this sickness earlier and correctly. (authors)

  15. Pharmacokinetics of total thyroxine after repeated oral administration of levothyroxine solution and its clinical efficacy in hypothyroid dogs.

    Science.gov (United States)

    van Dijl, I C; Le Traon, G; van de Meulengraaf, B D A M; Burgaud, S; Horspool, L J I; Kooistra, H S

    2014-01-01

    Oral levothyroxine (l-T4 ) supplementation is commonly used to treat hypothyroid dogs. Investigate the plasma profile and pharmacokinetics of total thyroxine (tT4 ) after PO administration of a l-T4 solution and its clinical efficacy in hypothyroid dogs. Ten dogs with naturally occurring hypothyroidism. After hypothyroidism diagnosis and supplementation with l-T4 solution PO q24h at 20 μg/kg BW for minimum 4 weeks, the plasma profile and pharmacokinetics of tT4 were determined over 34 hours and the clinical condition of the dogs was evaluated. Before dosing for pharmacokinetic evaluation, mean tT4 concentration was 23 ± 9 nmol/L. l-T4 was absorbed rapidly (tmax , 5 hours), reaching a mean maximal tT4 concentration of 56 ± 11 nmol/L. The apparent terminal half-life was 11.8 hours. Clinical signs of hypothyroidism improved or resolved in all dogs after 4 weeks of treatment. The dosage of 20 μg/kg PO q24h was judged appropriate in 5 dogs, and 4 dogs required slight increases (9-16%). Twice daily treatment, with a 30% increase in dosage, was necessary for 1 dog. The pharmacokinetics of l-T4 in hypothyroid dogs was similar to that reported in healthy euthyroid dogs. Clinical and hormonal responses to l-T4 solution were rapid in all dogs. The starting dosage of 20 μg/kg PO q24h was suitable for maintenance supplementation in 50% of the dogs, minor dosage modification was required in 4 other dogs, and treatment q12h was required in 1 dog. Copyright © 2014 by the American College of Veterinary Internal Medicine.

  16. Functional impact of treatment with ranibizumab under a reactive strategy in patients with neovascular age-related macular degeneration.

    Science.gov (United States)

    Gallego-Pinazo, R; Dolz-Marco, R; Andreu-Fenoll, M; Farrés, J; Monclús, L

    2017-03-01

    To analyse the functional recovery using a pro re nata (PRN) dosing strategy with intravitreal injections of ranibizumab for patients with neovascular age-related macular degeneration (AMD). An observational, retrospective, single-centre study, was conducted on patients with neovascular AMD managed with a PRN strategy with ranibizumab, and were followed-up for a minimum of 18 months. Sociodemographic and clinical data were collected from medical records. The percentage of visual acuity (VA) recovered after losing 5 or more letters was calculated taking into account the previous visit, as well as considering the best VA recorded prior to the retreament. The analysis included 128 patients. The mean (SD) follow-up period was 18.9 (2.3) months. The mean (SD) elapsed days between onset of symptoms and diagnosis, and between prescription and administration of treatment was 50.2 (57.4) and 10.9 (16.0), respectively. Only 108 patients were prescribed ranibizumab after losing 5 or more letters of VA. The mean (SD) VA recovery compared to the previous VA was 70.3% (114.4). On the other hand, the mean (SD) VA recovery when considering the best VA registered before the retreatment was 43.5% (112.9), with 59.4% of re-treatments having a VA recovery below 75%, and with 11.7% not presenting any VA recovery. A PRN dosing strategy with intravitreal ranibizumab for neovascular AMD may not be efficient in preserving and/or recovering VA in the long-term, due to a cumulative irreversible VA loss. Copyright © 2016 Sociedad Española de Oftalmología. Publicado por Elsevier España, S.L.U. All rights reserved.

  17. Long-term neurodevelopmental outcome in high-risk newborns in resource-limited settings: a systematic review of the literature.

    Science.gov (United States)

    Milner, K M; Neal, E F G; Roberts, G; Steer, A C; Duke, T

    2015-08-01

    Improving outcomes beyond survival for high-risk newborns in resource-limited settings is an emerging challenge. Global estimates demonstrate the scale of this challenge and significant gaps in morbidity outcome data in high mortality contexts. A systematic review was conducted to document the prevalence of neurodevelopmental impairment in high-risk newborns who were followed up into childhood in low- and middle-income countries. High-risk newborns were defined as low, very or extremely low birthweight, preterm infants or those surviving birth asphyxia or serious infections. Electronic databases were searched and articles screened for eligibility. Included articles were appraised according to STROBE criteria. Narrative review was performed and median prevalence of key neurodevelopmental outcomes was calculated where data quality allowed. 6959 articles were identified with sixty included in final review. At follow-up in early childhood, median estimated prevalence (inter-quartile range) of overall neurodevelopmental impairment, cognitive impairment and cerebral palsy were: for survivors of prematurity/very low birthweight 21.4% (11.6-30.8), 16.3% (6.3-29.6) and 11.2% (5.9-16.1), respectively, and for survivors of birth asphyxia 34.6% (25.4-51.5), 11.3% (7.7-11.8) and 22.8% (15.7-31.4), respectively. Only three studies reporting outcomes following newborn serious bacterial infections were identified. There was limited reporting of important outcomes such as vision and hearing impairment. Major challenges with standardised reporting of key exposure and developmental outcome variables and lack of control data were identified. Understanding the limitations of the available data on neurodevelopmental outcome in newborns in resource-limited settings provides clear direction for research and efforts to improve long-term outcome in high-risk newborns in these settings.

  18. Undergraduate teaching of forensic medicine in Saudi Arabia.

    Science.gov (United States)

    Madadin, Mohammed; Al-Saif, Dalia M; Khamis, Amar Hassan; Taha, Attia Z; Kharoshah, Magdy A; Alsayyah, Ahmed; Alfehaid, Suha; Yaghmour, Khalid; Hakami, Ahmad Yahia; Bamousa, Manal S; Menezes, Ritesh G; Almadani, Osama M

    2016-07-01

    Medico-legal tasks are not exclusive to forensic medical experts -any physician may face medico-legal issues in his career. Hence, the practice of medicine requires education in legal issues. In Saudi Arabia, there are 30 universities with medical colleges, but we do not know how they teach undergraduate forensic medicine and medico-legal issues. The aim of this study was to discover undergraduate training courses in forensic medicine in Saudi universities. We conducted a cross-sectional study involving all colleges of medicine in Saudi Arabia. A structured, self-administered questionnaire containing 13 items relating to the undergraduate forensic medicine course was distributed. Out of a total of 30 universities, 27 universities responded. Of these 27 universities, 16 (59.26%) teach forensic medicine to undergraduate medical students, and 11 (40.74%) do not teach forensic medicine in their undergraduate curriculum. Of the 27 universities that responded, none has a department of forensic medicine. Eleven universities that do not teach forensic medicine have no forensic medicine unit/division or faculty at all. Forensic medicine belongs to the pathology department in 11 universities, while it belongs to different departments in five universities. There is variation in teaching methods, years where the course is taught and length of the course. Practical and morgue visits take place in 7/16 (43.8%) universities, while 9/16 (56.3%) universities only teach the theoretical aspects of forensic medicine. All 16 universities teach forensic medicine only to medical students and do not teach it to students in other colleges such as dentistry and nursing. © The Author(s) 2016.

  19. Immunohistochemical evaluation of E-cadherin expression in basal cell carcinoma of the skin

    Directory of Open Access Journals (Sweden)

    Vladimír Bartoš

    2015-08-01

    Full Text Available Introduction: E-cadherin is important cell-cell adhesion molecule, that plays a crucial role in the maintenance of tissue microarchitecture. In many human malignancies, reduced or loss of E-cadherin production in neoplastic cells correlates with tumor dedifferentiation and acquisition of the invasive and metastatic potential. In contrast to most other cancers, basal cell carcinoma (BCC of the skin possess some unique features, such as slow local growth, strong stroma-dependency, and virtual absence of metastases. Aim: In the present study, we immunohistochemically evaluated expression of E-cadherin in a set of cutaneous BCCs. Material and methods: Study group consisted of 41 primary BCCs cathegorized into non-infiltrative subroup (superfical and nodular subtypes and infiltrative subroup (nodular-infiltrative and infiltrative subtypes. Results: E-cadherin was expressed in all tumor specimens with variable quantitative range and intensity. There were 19 cases (46.3 % with preserved and 22 cases (53.7 % with reduced E-cadherin expression. In superficial, nodular, nodular-infiltrative and infiltrative BCC subtypes, reduced E-cadherin immunoreactivity was found in 40 % (2/5, 56.2 % (9/16, 54.5 % (6/11 and 55.5 % (5/9, respectively. We did not confirm a significant correlation between expression of E-cadherin and both given, non-infiltrative and infiltrative BCC subgroup. None of the tumors examined showed apparent decreasing immunostaining intensity in tumor tissue with increasing depth of invasion. There were not convincing differences either between the central and peripheral parts of tumor mass, or in the vertical dimension. Conclusions: Reduction of E-cadherin expression per se does not seem to directly contribute to the acqusition of more aggressive phenotype in cutaneous BCC. This may represent another peculiarity, by which BCC differs from the most other epithelial malignancies and reflect a distinct tumor biology.

  20. Impact of single annual treatment and four-monthly treatment for hookworm and Ascaris lumbricoides, and factors associated with residual infection among Kenyan school children.

    Science.gov (United States)

    Kepha, Stella; Mwandawiro, Charles S; Anderson, Roy M; Pullan, Rachel L; Nuwaha, Fred; Cano, Jorge; Njenga, Sammy M; Odiere, Maurice R; Allen, Elizabeth; Brooker, Simon J; Nikolay, Birgit

    2017-02-09

    School-based deworming is widely implemented in various countries to reduce the burden of soil-transmitted helminths (STHs), however, the frequency of drug administration varies in different settings. In this study, we compared the impact of a single annual treatment and 4-monthly treatment over a follow-up among Kenyan school children, and investigated the factors associated with residual infection. We performed a secondary analysis of data from a randomized trial investigating whether deworming for STHs alters risk of acquiring malaria. Children received either a single treatment or 4-monthly albendazole treatments were followed longitudinally from February 2014 to October 2014. The relative impact of treatment and factors associated with residual infections were investigated using mixed-effects regression models. Predisposition to infection was assessed based on Spearman's rank and Kendall's Tau correlation coefficients. In the 4-monthly treatment group, the proportion of children infected with hookworm decreased from 59.9 to 5.7%, while Ascaris lumbricoides infections dropped from 55.7 to 6.2%. In the single treatment group, hookworm infections decreased over the same time period from 58.7 to 18.3% (12.6% absolute difference in reduction, 95% CI: 8.9-16.3%), and A. lumbricoides from 56.7 to 23.3% (17.1% absolute difference in reduction, 95% CI: 13.1-21.1%). There was strong evidence for predisposition to both STH types. Residual hookworm infection among children on 4-monthly treatment were associated with male sex and baseline nutritional status, whereas A. lumbricoides infection was associated with individual and school-level infection at baseline, latrine cleanliness at schools. This study found that 4-monthly treatment w more effective than single annual treatment. Repeated treatments led to dramatic reductions in the intensities of STHs, but did not completely clear infections among school children in Kenya, a presumed reflection of reinfection in a setting

  1. Fatal pyogranulomatous myocarditis in 10 Boxer puppies.

    Science.gov (United States)

    Detmer, Susan E; Bouljihad, Mostafa; Hayden, David W; Schefers, Jeremy M; Armien, Anibal; Wünschmann, Arno

    2016-03-01

    Over a period of 5 years, 10 pure-bred Boxer puppies, 9-16 weeks old, were presented with a history of sudden death and were diagnosed with pyogranulomatous myocarditis. The myocarditis was characterized by a mixed infiltrate composed predominantly of neutrophils and macrophages. In our retrospective study, original case records and archived materials were examined. All dogs were positive for Borrelia burgdorferi on immunohistochemistry (IHC). There was no evidence of infectious agents in formalin-fixed, paraffin-embedded (FFPE) heart tissue sections stained with hematoxylin and eosin, Ziehl-Neelsen, Gram, Grocott methenamine silver, Warthin-Starry, Von Kossa, and Steiner-Chapman stains. IHC for Chlamydia sp., Toxoplasma gondii, Neospora caninum, West Nile virus, and canine parvovirus also yielded a negative result in all dogs. Polymerase chain reaction testing for vector-borne pathogens on heart tissue from 9 of the dogs (1 frozen and 8 FFPE samples) yielded positive results for 1 dog with B. burgdorferi as well as Anaplasma phagocytophilum in another dog. Subsequently, 2 additional cases were found in a French Bulldog and a French Bulldog-Beagle mix that had identical morphology, test results, age, and seasonality to these 10 Boxer dogs. The similarities in the seasonality, signalment of the affected dogs, and the gross and microscopic lesions suggest a common etiology. Positive IHC and morphologic similarities to human Lyme carditis indicate that B. burgdorferi is likely the agent involved. An additional consideration for these cases is the possibility of a breed-specific autoimmune myocarditis or potential predisposition for cardiopathogenic agents in young Boxers. © 2016 The Author(s).

  2. Soleus muscle injury: sensitivity of ultrasound patterns

    Energy Technology Data Exchange (ETDEWEB)

    Balius, Ramon [Sport Catalan Council, Generalitat de Catalunya, Barcelona (Spain); Clinica CMI Diagonal, Barcelona (Spain); Rodas, Gil [F.C. Barcelona Medical Services, Barcelona (Spain); Pedret, Carles [Clinica CMI Diagonal, Barcelona (Spain); Clinica Mapfre de Medicina del Tenis, Sports Medicine and Imaging Department, Barcelona (Spain); Centre de Diagnostic per Imatge de Tarragona, Tarragona (Spain); Capdevila, Lluis [Universitat Autonoma de Barcelona, Laboratory of Sport Psychology, Barcelona (Spain); Alomar, Xavier [Clinica Creu Blanca, Barcelona (Spain); Bong, David A. [Instituto Poal de Reumatologia, Barcelona (Spain)

    2014-06-15

    To assess the sensitivity of ultrasound in detecting soleus muscle lesions diagnosed on magnetic resonance imaging (MRI) and to characterize their location, ultrasound pattern, and evolution. Ultrasound and MRI studies were performed between May 2009 and February 2013 on all patients who presented to the Medical Services Clinic of the Catalan Sport Council with the initial onset of sharp pain in the calf compatible with injury of the soleus muscle. An inter-observer ultrasound reliability study was also performed. A total of 55 cases of soleus injury were studied prospectively (22 with right leg involvement, 33 left) by ultrasound and MRI, which was utilized as the ''gold standard.'' In MRI studies, 24 cases (43.7 %) had myofascial injuries that were localized in the posterior aponeurosis (PMF) in 15 cases (27.3 %) and in the anterior aponeurosis (AMF) in 9 (16.4 %). Thirty-one cases (56.3 %) were musculotendinous injuries, with 9 cases (16.4 %) in the medial aponeurosis (MMT), 11 cases (20 %) in the lateral aponeurosis (LMT), and 11 cases (20 %) in the central tendon (CMT). In comparison to MRI, ultrasound was able to detect injury to the soleus in 27.2 % of cases. No injuries were detected by ultrasound alone. Posterior myofascial injuries were more likely to be detected by ultrasound than anterior myofascial injuries or all types of musculotendinous injuries. Ultrasound patterns for each type of injury were described. Ultrasound is not a sensitive technique for detecting and assessing soleus traumatic tears compared with MRI, although the sensitivity is enhanced by a thorough anatomically based ultrasound examination. Timing of the ultrasound examination may be of importance. Each type of soleus injury appears to have a characteristic ultrasound pattern based on a defect of connective expansions, the existence of small myofascial filiform collections, and the rarefaction of the fibrillar area. (orig.)

  3. Does mean heart dose sufficiently reflect coronary artery exposure in left-sided breast cancer radiotherapy. Influence of respiratory gating

    International Nuclear Information System (INIS)

    Becker-Schiebe, Martina; Stockhammer, Maxi; Franz, Heiko; Hoffmann, Wolfgang; Wetzel, Fabian

    2016-01-01

    With extensive use of systemic treatment, the issue of cardiac mortality after breast cancer radiation (RT) is still important. The aim of our analysis was to clarify whether the dose to one surrogate parameter (e. g., mean heart dose, as used in most studies) reflects the dose to the other cardiovascular structures especially the left anterior descending artery depending on breathing-adapted RT. A total of 130 patients who underwent adjuvant RT (50.4 Gy plus boost 9-16 Gy) were evaluated. In all, 71 patients were treated with free-breathing and 59 patients using respiratory monitoring (gated RT). Dosimetric associations were calculated. The mean dose to the heart (Dmean heart) was reduced from 2.7 (0.8-5.2) Gy to 2.4 (1.1-4.6) Gy, the Dmean LAD (left anterior descending artery) decreased from 11.1 (1.3-28.6) Gy to 9.3 (2.2-19.9) Gy with gated RT (p = 0.04). A significant relationship was shown for Dmean heart -Dmean LAD, V25heart-Dmean LAD and Dmax heart-Dmax LAD for gated patients only (p < 0.01). For every 1 Gy increase in Dmean heart, mean LAD doses rose by 3.6 Gy, without gating V25 ≤5 % did not assure a benefit and resulted in Dmean LAD between 1.3 and 28.6 Gy. A significant reduction and association of heart and coronary artery (LAD) doses using inspiratory gating was shown. However, in free-breathing plans commonly measured dose constraints do not allow precise estimation of the dose to the coronary arteries. (orig.) [de

  4. Effects of nonsurgical periodontal therapy in patients with moderately controlled type 2 diabetes mellitus and chronic periodontitis in Nepalese population.

    Science.gov (United States)

    Goel, Khushboo; Pradhan, Shaili; Bhattarai, Madhur Dev

    2017-01-01

    Despite several investigations, evidence is still controversial regarding the effect of periodontal treatment on diabetes. This study evaluates and compares the effect on glycemic control and periodontal status with or without nonsurgical periodontal therapy in patients with type 2 diabetes mellitus and chronic periodontitis in a Nepalese population. A total of 82 patients attending the diabetes clinic and fulfilling enrollment criteria with moderate to severe periodontitis were selected. They were assigned in an alternative sequence, into test and control group. Both groups were instructed to continue with their medical treatment without modifications. Scaling and root surface debridement were performed in the test group whereas the control group received oral hygiene instructions with no treatment during the 3-month study period. There were 41 participants in each group with the mean age of 50.66±7.70 and 53.80±9.16 years, average diabetes duration of 6.32±4.21 and 6.24±4.00 years, mean body mass index of 24.78±1.85 and 24.6±1.79 kg/m 2 , and glycated hemoglobin (HbA1c) level of 6.71±0.50% and 6.80±0.45%, in the test and control group, respectively. After 3 months, there was significant reduction in HbA1c levels in the test group compared to the control group ( p =0.029). Clinical periodontal parameters of gingival index, probing depth (PD), and clinical attachment level (CAL) significantly improved in the test group ( p 0.001) who showed an increase by 0.05 mm. This study showed that nonsurgical periodontal therapy may have a beneficial effect on HbA1c level in moderately controlled type 2 diabetic patients.

  5. Using motivational interviewing for weight feedback to parents of young children.

    Science.gov (United States)

    Dawson, Anna M; Brown, Deirdre A; Cox, Adell; Williams, Sheila M; Treacy, Lee; Haszard, Jill; Meredith-Jones, Kim; Hargreaves, Elaine; Taylor, Barry J; Ross, Jim; Taylor, Rachael W

    2014-06-01

    To determine whether a single session of motivational interviewing (MI) for feedback of a child's overweight status promotes engagement in treatment following screening. One thousand ninety-three children aged 4-8 years were recruited through primary and secondary care to attend health screening, including assessment of parenting practices and motivation (questionnaire). Families with normal-weight children were informed about their child's weight but had no further involvement. Parents of overweight (body mass index ≥ 85th percentile) children (n = 271) were randomised to receive weight feedback via MI or best practice care (BPC) using a traffic light concept to indicate degree of health risk. Follow-up interviews were held 2 weeks later to examine intervention uptake, changes to motivation and behaviour, and parental response to feedback. Recruitment into the intervention was high (76%) and not altered by feedback condition (percentage difference 6.6 (95% confidence interval -2.9, 16.0). High scores on the Health Care Climate Questionnaire (rating of the interviewer) indicated satisfaction with how the information was provided to parents. No differences were observed in multiple indicators of harm. However, self-determined motivation for healthy life-styles was significantly higher in the MI condition at follow-up (0.18: 0.00, 0.35), after only a single session of MI. MI and BPC were both successful in encouraging parents to participate in a family-based intervention, with MI offering little significant benefit over BPC. A traffic light approach to weight feedback is a suitable way of providing sensitive information to parents not expecting such news. © 2014 The Authors. Journal of Paediatrics and Child Health © 2014 Paediatrics and Child Health Division (Royal Australasian College of Physicians).

  6. Cultivation of vancomycin-resistant enterococci and methicillin-resistant staphylococci from input and output samples of German biogas plants.

    Science.gov (United States)

    Glaeser, Stefanie P; Sowinsky, Olivia; Brunner, Jana S; Dott, Wolfgang; Kämpfer, Peter

    2016-03-01

    Vancomycin-resistant enterococci (VRE) and methicillin-resistant staphylococci (MRS) were detected in two mesophilic German biogas plants (BGPs) using selective pre-enrichment methods combined with cultivation on CHROMagar media and antibiotic resistance gene screening. Genetic fingerprinting and 16S rRNA gene sequencing showed the presence of enterococci isolated by the VRE selective cultivation (67 isolates) in input and output samples of BGPs. In contrast, MRS (44 isolates) were detected in input, but in none of the output samples. Enterococcus isolates showed highest 16S rRNA gene sequence similarity (>99.8%) to E. lemanii, E. casseliflavus/E. gallinarium or E. devriesei/E. pseudoavium/E. viikkiensis and carried vanA, vanB and/or vanC1 genes. Enterococcus faecium and E. faecalis VRE were not detected, but isolates closely related to those species (>99.9% 16S rRNA gene sequence similarity) were detected by the MRS selective cultivation methods. Staphylococcus isolates shared highest 16S rRNA gene sequence similarity (>99.9%) with S. haemolyticus, S. lentus and S. sciuri and carried mecA genes. Methicillin-resistant S. aureus (MRSA) were not detected. In summary, manure from livestock husbandry contained both, VRE and MRS. VRE were also detected in output samples, indicating that enterococci with vancomycin resistance genes could be release into the environment by the application of BGP output material as biofertilizers. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  7. Gastrointestinal Findings in the Largest Series of Patients With Hereditary Biallelic Mismatch Repair Deficiency Syndrome: Report from the International Consortium.

    Science.gov (United States)

    Aronson, Melyssa; Gallinger, Steven; Cohen, Zane; Cohen, Shlomi; Dvir, Rina; Elhasid, Ronit; Baris, Hagit N; Kariv, Revital; Druker, Harriet; Chan, Helen; Ling, Simon C; Kortan, Paul; Holter, Spring; Semotiuk, Kara; Malkin, David; Farah, Roula; Sayad, Alain; Heald, Brandie; Kalady, Matthew F; Penney, Lynette S; Rideout, Andrea L; Rashid, Mohsin; Hasadsri, Linda; Pichurin, Pavel; Riegert-Johnson, Douglas; Campbell, Brittany; Bakry, Doua; Al-Rimawi, Hala; Alharbi, Qasim Kholaif; Alharbi, Musa; Shamvil, Ashraf; Tabori, Uri; Durno, Carol

    2016-02-01

    Hereditary biallelic mismatch repair deficiency (BMMRD) is caused by biallelic mutations in the mismatch repair (MMR) genes and manifests features of neurofibromatosis type 1, gastrointestinal (GI) polyposis, and GI, brain, and hematological cancers. This is the first study to characterize the GI phenotype in BMMRD using both retrospective and prospective surveillance data. The International BMMRD Consortium was created to collect information on BMMRD families referred from around the world. All patients had germline biallelic MMR mutations or lack of MMR protein staining in normal and tumor tissue. GI screening data were obtained through medical records with annual updates. Thirty-five individuals from seven countries were identified with BMMRD. GI data were available on 24 of 33 individuals (73%) of screening age, totaling 53 person-years. The youngest age of colonic adenomas was 7, and small bowel adenoma was 11. Eight patients had 19 colorectal adenocarcinomas (CRC; median age 16.7 years, range 8-25), and 11 of 18 (61%) CRC were distal to the splenic flexure. Eleven patients had 15 colorectal surgeries (median 14 years, range 9-25). Four patients had five small bowel adenocarcinomas (SBC; median 18 years, range 11-33). Two CRC and two SBC were detected during surveillance within 6-11 months and 9-16 months, respectively, of last consecutive endoscopy. No patient undergoing surveillance died of a GI malignancy. Familial clustering of GI cancer was observed. The prevalence and penetrance of GI neoplasia in children with BMMRD is high, with rapid development of carcinoma. Colorectal and small bowel surveillance should commence at ages 3-5 and 8 years, respectively.

  8. The impact of duration on effectiveness of exercise, the implication for periodization of training and goal setting for individuals who are overfat, a meta-analysis.

    Science.gov (United States)

    Clark, J E

    2016-12-01

    Given the assumption that all methods of exercise, e.g., endurance (ET), resistance (RT), or combination of both (E+R), can induce a beneficial effect size (ES) for changes in body composition and health status of individuals who are overfat. Thus the aim and purpose of this study is to evaluate the current body of knowledge to address the question as to the impact that the duration of exercise has on its relative effectiveness for inducing health and body compositional changes in individuals who are overfat to assist with developing periodized exercise protocols and establishing short and long term goals. A tiered meta-analysis of 92-studies and 200-exercise groupings were used for establishing pooled ES within and between groupings based on the increments of 4-week of duration and study designs of ≤8, 9-16, 17-23, 24-36, and ≥36 weeks. Analysis based on random-effect of response indicates a continuum of effectiveness within and between ET, RT and E+R based on duration. Where beneficial effectiveness is not indicated for any measures until after 8-weeks of continuous training with progressive effectiveness being noted in changes to cardiorespiratory fitness, inflammatory cytokines, and alteration of metabolic status from 12-weeks through 32-weeks of continuous training. Results indicate a greater ES for RT and E+R versus ET early in intervention that equalizes with longer durations. Supporting the use of RT and E+R within a periodized program. And secondarily, goals should be established first on performance gains and second body composition or health status modifications for the individual who is overfat.

  9. Kribbella catacumbae sp. nov. and Kribbella sancticallisti sp. nov., isolated from whitish-grey patinas in the catacombs of St Callistus in Rome, Italy.

    Science.gov (United States)

    Urzì, Clara; De Leo, Filomena; Schumann, Peter

    2008-09-01

    Several nocardioform actinomycetes were isolated from tufaceous surfaces with whitish-grey patinas in the catacombs of St Callistus in Rome, Italy. The morphology of the isolates and their chemotaxonomic characteristics such as LL-diaminopimelic acid in the cell-wall peptidoglycan, the major menaquinone of MK-9(H(4)), phosphatidylinositol, phosphatidylcholine, phosphatidylglycerol and diphosphatidylglycerol as the major polar lipids, as well as complex cellular fatty acid patterns with anteiso-C(15:0), iso-C(16:0) and iso-C(15:0) as predominating components, were in agreement with their classification as members of the genus Kribbella by 16S rRNA gene sequence analysis. The isolates fell into two clusters as revealed by their ribosomal intergenic spacer, RiboPrint and cellular fatty acid patterns and by their MALDI-TOF mass spectra. The two clusters were represented by the strains BC631(T) and BC633(T) which shared 97.9% 16S rRNA gene sequence similarity. Strain BC631(T) represented a cluster of yellow pigmented strains and was a phylogenetic neighbour of Kribbella koreensis DSM 17837(T) (gene sequence similarity 98.0%), while strain BC633(T) was related to Kribbella flavida DSM 17836(T) and Kribbella karoonensis DSM 17344(T) (gene sequence similarities of 98.8% and 98.6%, respectively). Strains BC631(T) and BC633(T) could be differentiated from each other and from their closest phylogenetic neighbours by phenotypic characteristics and DNA-DNA relatedness values far below 70%. It is concluded that the two new strains represent two novel species, for which the names Kribbella catacumbae sp. nov. (type strain BC631(T)=DSM 19601(T)=JCM 14968(T)) and Kribbella sancticallisti sp. nov. (type strain BC633(T)=DSM 19602(T)=JCM 14969(T)) are proposed.

  10. Mobilicoccus pelagius gen. nov., sp. nov. and Piscicoccus intestinalis gen. nov., sp. nov., two new members of the family Dermatophilaceae, and reclassification of Dermatophilus chelonae (Masters et al. 1995) as Austwickia chelonae gen. nov., comb. nov.

    Science.gov (United States)

    Hamada, Moriyuki; Iino, Takao; Iwami, Takahiro; Harayama, Shigeaki; Tamura, Tomohiko; Suzuki, Ken-ichiro

    2010-01-01

    Two Gram-positive bacteria, designated strains Aji5-31(T) and Ngc37-23(T), were isolated from the intestinal tracts of fishes. 16S rRNA gene sequence analysis indicated that both strains were related to the members of the family Dermatophilaceae, with 95.6-96.9% 16S rRNA gene sequence similarities. The family Dermatophilaceae contains 2 genera and 3 species: Dermatophilus congolensis, Dermatophilus chelonae and Kineosphaera limosa. However, it has been suggested that the taxonomic position of D. chelonae should be reinvestigated using a polyphasic approach, because the chemotaxonomic characteristics are not known (Stackebrandt, 2006; Stackebrandt and Schumann, 2000). Our present study revealed that strains Aji5-31(T), Ngc37-23(T) and D. chelonae NBRC 105200(T) should be separated from the other members of the family Dermatophilaceae on the basis of the following characteristics: the predominant menaquinone of strain Aji5-31(T) is MK-8(H(2)), strain Ngc37-23(T) possesses iso- branched fatty acids as major components, and the menaquinone composition of D. chelonae is MK-8(H(4)), MK-8 and MK-8(H(2)) (5 : 3 : 2, respectively). On the basis of these distinctive phenotypic characteristics and phylogenetic analysis results, it is proposed that strains Aji5-31(T) and Ngc37-23(T) be classified as two novel genera and species of the family Dermatophilaceae. The names are Mobilicoccus pelagius gen. nov., sp. nov. and Piscicoccus intestinalis gen. nov., sp. nov., and the type strains are Aji5-31(T) (=NBRC 104925(T) =DSM 22762(T)) and Ngc37-23(T) (=NBRC 104926(T) =DSM 22761(T)), respectively. In addition, D. chelonae should be reassigned to a new genus of the family Dermatophilaceae with the name Austwickia chelonae gen. nov., comb. nov.

  11. Herd and individual animal prevalence of bovine brucellosis with associated risk factors on dairy farms in Haryana and Punjab in India.

    Science.gov (United States)

    Chand, Puran; Chhabra, Rajesh

    2013-08-01

    Herd and individual animal prevalence along with associated risk factors of bovine brucellosis was assessed on dairy farms located in 22 districts in Haryana and Punjab of India. Examination of 4,580 female animals of 119 dairy farms by Rose Bengal test and enzyme-linked immunosorbent assay revealed that an overall herd prevalence was 65.54% (78/119) and individual animal prevalence was 26.50 % (1,214/4,580). Herd prevalence in Haryana was 62.79% which was not significantly different (P = 0.4208) from Punjab (72.72%). Individual animal prevalence was 34.15% in Punjab which was significantly higher (P brucellosis on dairy farms was detected in 20 of the 22 districts, of which 12 districts were in Haryana and 8 in Punjab. Risk factors such as species of animals, age of animals, herd size, awareness of dairymen for brucellosis, entry of a purchased animals on the farm, abortion on farm, use of calving pens, type of breeding, and type of farming were analyzed. The study indicated that the odds ratio (OR) was significant with risk factors of species (OR = 1.63; 95 %CI = 1.40-1.90; P brucellosis among dairymen (OR = 21.65; 95%CI = 2.63-178.04; P = 0.0042), entry of purchased animal on the farm (OR = 9.16; 95%CI = 2.38-35.18; P = 0.0012), abortion in animals (OR = 5.57; 95%CI = 1.92-16.10; P = 0.0015) and on cow farm (OR = 3.43; 95 %CI = 1.33-8.82; P = 0.0105). While the OR was insignificant (P > 0.05) with risk factors of herd size, use of calving pen on farms, type of breeding and on buffalo and mixed type of farms.

  12. Competitive Inhibition of Renal Tubular Secretion of Gemifloxacin by Probenecid▿

    Science.gov (United States)

    Landersdorfer, Cornelia B.; Kirkpatrick, Carl M. J.; Kinzig, Martina; Bulitta, Jürgen B.; Holzgrabe, Ulrike; Drusano, George L.; Sörgel, Fritz

    2009-01-01

    Probenecid interacts with transport processes of drugs at several sites in the body. For most quinolones, renal clearance is reduced by concomitant administration of probenecid. The interaction between gemifloxacin and probenecid has not yet been studied. We studied the extent, time course, site(s), and mechanism of this interaction. Seventeen healthy volunteers participated in a randomized, two-way crossover study. Subjects received 320 mg gemifloxacin as an oral tablet without and with 4.5 g probenecid divided in eight oral doses. Drug concentrations in plasma and urine were analyzed by liquid chromatography-tandem mass spectrometry. WinNonlin was used for noncompartmental analysis, compartmental modeling, and statistics, and NONMEM was used for visual predictive checks. Concomitant administration of probenecid increased plasma gemifloxacin concentrations and amounts excreted in urine compared to baseline amounts. Data are average estimates (percent coefficients of variation). Modeling showed a competitive inhibition of the renal tubular secretion of gemifloxacin by probenecid as the most likely mechanism of the interaction. The estimated Km and Vmax for the saturable part of renal elimination were 9.16 mg/liter (20%) and 113 mg/h (21%), respectively. Based on the molar ratio, the affinity for the renal transporter was 10-fold higher for gemifloxacin than for probenecid. Since probenecid reached an ∼200-times-higher area under the molar concentration-time curve from 0 to 24 h than gemifloxacin, probenecid inhibited the active tubular secretion of gemifloxacin. Probenecid also reduced the nonrenal clearance of gemifloxacin from 25.2 (26%) to 21.0 (23%) liters/h. Probenecid inhibited the renal tubular secretion of gemifloxacin, most likely by a competitive mechanism, and slightly decreased nonrenal clearance of gemifloxacin. PMID:19564368

  13. Competitive inhibition of renal tubular secretion of gemifloxacin by probenecid.

    Science.gov (United States)

    Landersdorfer, Cornelia B; Kirkpatrick, Carl M J; Kinzig, Martina; Bulitta, Jürgen B; Holzgrabe, Ulrike; Drusano, George L; Sörgel, Fritz

    2009-09-01

    Probenecid interacts with transport processes of drugs at several sites in the body. For most quinolones, renal clearance is reduced by concomitant administration of probenecid. The interaction between gemifloxacin and probenecid has not yet been studied. We studied the extent, time course, site(s), and mechanism of this interaction. Seventeen healthy volunteers participated in a randomized, two-way crossover study. Subjects received 320 mg gemifloxacin as an oral tablet without and with 4.5 g probenecid divided in eight oral doses. Drug concentrations in plasma and urine were analyzed by liquid chromatography-tandem mass spectrometry. WinNonlin was used for noncompartmental analysis, compartmental modeling, and statistics, and NONMEM was used for visual predictive checks. Concomitant administration of probenecid increased plasma gemifloxacin concentrations and amounts excreted in urine compared to baseline amounts. Data are average estimates (percent coefficients of variation). Modeling showed a competitive inhibition of the renal tubular secretion of gemifloxacin by probenecid as the most likely mechanism of the interaction. The estimated K(m) and Vmax for the saturable part of renal elimination were 9.16 mg/liter (20%) and 113 mg/h (21%), respectively. Based on the molar ratio, the affinity for the renal transporter was 10-fold higher for gemifloxacin than for probenecid. Since probenecid reached an approximately 200-times-higher area under the molar concentration-time curve from 0 to 24 h than gemifloxacin, probenecid inhibited the active tubular secretion of gemifloxacin. Probenecid also reduced the nonrenal clearance of gemifloxacin from 25.2 (26%) to 21.0 (23%) liters/h. Probenecid inhibited the renal tubular secretion of gemifloxacin, most likely by a competitive mechanism, and slightly decreased nonrenal clearance of gemifloxacin.

  14. Prolactin levels are associated with a pro-inflammatory body mass distribution among women with systemic lupus erythematosus.

    Science.gov (United States)

    Elera-Fitzcarrald, C; Ugarte-Gil, M F; Gamboa-Cárdenas, R V; Zevallos, F; Medina, M; Cucho-Venegas, J M; Perich-Campos, R A; Alfaro-Lozano, J L; Rodriguez-Bellido, Z; Alarcón, G S; Pastor-Asurza, C A

    2017-07-01

    Objectives The objective of this study was to determine whether prolactin levels are associated with a pro-inflammatory body mass distribution in women with systemic lupus erythematosus (SLE). Methods This cross-sectional study was conducted in consecutive female SLE patients seen in our rheumatology department from January 2012 to July 2015. Prolactin was measured in ng/ml. Body mass distribution was measured by dual energy x-ray absorptiometry and it was divided into subtotal (whole body excluding the head), subtotal bone mineral content, lean mass index (appendicular lean mass/height 2 ), subtotal trunk and leg fat percentages and trunk-to-leg fat ratio. The association between prolactin levels and body mass distribution components was evaluated by univariable and multivariable linear regression models adjusting for possible confounders. Results One hundred and eighty-five patients were evaluated; their mean (SD) age at diagnosis was 34.8 (13.8) years; nearly all patients were Mestizo. Patients included in this study were comparable to the rest of the cohort in terms of age, disease duration, SLEDAI, SDI and body mass index. Disease duration was 7.3 (6.6) years. The SLEDAI was 5.2 (4.3) and the SDI 0.9 (1.3). Prolactin levels were 18.9 (16.7) ng/ml. In univariable analyses, prolactin was negatively associated with bone mineral density, bone mineral content, leg fat percentage and lean mass index, and positively associated with trunk-to-leg fat ratio. In the multivariable analyses, prolactin was negatively associated with bone mineral content and positively associated with trunk-to-leg fat ratio. Conclusions Higher prolactin levels are associated with a pro-inflammatory body mass distribution in SLE patients.

  15. Contralateral reversed distal femoral locking plate for fixation of subtrochanteric femoral fractures.

    Science.gov (United States)

    Gogna, Paritosh; Mukhopadhyay, Reetadyuti; Singh, Amanpreet; Devgan, Ashish; Arora, Sahil; Batra, Amit; Yadav, Sushil Kumar

    2015-01-01

    Subtrochanteric fractures of the femur are being managed successfully with various intramedullary and extramedulary implants with reasonable success. However, these implants require precise placement under image intensifier guidance, which exposes the surgeon to substantial amount of radiation. It also restricts the management of these fractures at peripheral centers where facility of image intensifiers is not available. Keeping this in mind we designed this study to identify if contralateral reversed distal femoral locking plate can be used successfully without the use of image intensifier. Twenty-four consecutive patients (18 men and 6 women) with a mean age of 28 years (range 19-47 years) suffering subtrochanteric fractures of the femur underwent open reduction and internal fixation with reversed contralateral distal femoral locking plate. The outcome was assessed at the mean follow-up period of 3.2 years (range 2-4.6 years) using the Harris hip score. Twenty-one fractures united with the primary procedure, with a mean time of consolidation being 11 weeks (range, 9-16 weeks). One patient developed superficial suture line infection, which resolved with oral antibiotics. Another patient had a fall 3 weeks after surgery and broke the plate. Repeat surgery with reversed distal femoral locking compression plate was performed along with bone grafting and the fracture united. Two cases had nonunion, which went in for union after bone grafting. The mean Harris hip score at the time of final follow-up was 90.63 (range 82-97). The reversed contralateral distal femoral plate is a biomechanically sound implant, which when used for fixation of the subtrochanteric fractures with minimal soft tissue stripping shows results comparable to those achieved by using other extramedullary implants as well as intramedullary devices. The added advantage of this implant is its usability in the absence of an image intensifier.

  16. Assessment of surf zone environmental variables in a southwestern Atlantic sandy beach (Monte Hermoso, Argentina).

    Science.gov (United States)

    Menéndez, M Clara; Fernández Severini, Melisa D; Buzzi, Natalia S; Piccolo, M Cintia; Perillo, Gerardo M E

    2016-08-01

    The aim of this study was to investigate the temporal dynamics (monthly/tidal) of water temperature, salinity, chlorophyll-a (chlo-a), suspended particulate matter (SPM), particulate organic carbon (POC), and dissolved nutrients in the surf zone of Monte Hermoso sandy beach, Argentina. We also aimed to understand the underlying mechanisms responsible for the observed variability. Sampling was carried out approximately monthly (September 2009-November 2010), and all samples were collected in a fixed station during high and low tide. Water temperature showed a clear seasonal variability (July: 9 °C-December: 26.5 °C) and a thermal amplitude of 17.5 °C. Salinity ranged from 33 to 37, without a pronounced seasonality. SPM (10-223 mg L(-1)) and POC concentrations (399-6445 mg C m(-3)) were high in surf zone waters. Chlo-a (0.05-9.16 μg L(-1)) was low and did not evidence the occurrence of surf diatom accumulations. Dissolved nutrient concentration was quite fluctuating. None of the variables seemed to be affected by tidal stage. The results showed how fluctuating the physico-chemical and biological variables can be in this particular system. The observed variability can be related with local beach conditions but also with regional processes. The study area is highly influenced by a neighbor estuary and as a consequence, could be vulnerable to their seasonal and inter-annual dynamics. All of these characteristics must be considered for further studies and planning of the uses of natural resources and should be taken into account in any environmental monitoring program conducted in a similar beach system.

  17. Effect modification by delta-aminolevulinic acid dehydratase, vitamin D receptor, and nitric oxide synthase gene polymorphisms on associations between patella lead and renal function in lead workers.

    Science.gov (United States)

    Weaver, Virginia M; Lee, Byung-Kook; Todd, Andrew C; Ahn, Kyu-Dong; Shi, Weiping; Jaar, Bernard G; Kelsey, Karl T; Lustberg, Mark E; Silbergeld, Ellen K; Parsons, Patrick J; Wen, Jiayu; Schwartz, Brian S

    2006-09-01

    Genetic polymorphisms that affect lead toxicokinetics or toxicodynamics may be important modifiers of risk for adverse outcomes in lead-exposed populations. We recently reported associations between higher patella lead, which is hypothesized to represent a lead pool that is both bioavailable and cumulative, and adverse renal outcomes in current and former Korean lead workers. In the present study, we assessed effect modification by polymorphisms in the genes encoding for delta-aminolevulinic acid dehydratase (ALAD), the vitamin D receptor (VDR), and endothelial nitric oxide synthase on those associations. Similar analyses were conducted with three other lead biomarkers. Renal function was assessed via blood urea nitrogen, serum creatinine, measured and calculated creatinine clearances, urinary N-acetyl-beta-D-glucosaminidase, and retinol-binding protein. Mean (SD) blood, patella, tibia, and dimercaptosuccinic acid-chelatable lead values were 30.9 (16.7) microg/dl, 75.1 (101.1)and 33.6 (43.4) microg Pb/g bone mineral, and 0.63 (0.75) microg Pb/mg creatinine, respectively, in 647 lead workers. Little evidence of effect modification by genotype on associations between patella lead and renal outcomes was observed. The VDR polymorphism did modify associations between the other lead biomarkers and the serum creatinine and calculated creatinine clearance. Higher lead dose was associated with worse renal function in participants with the variant B allele. Models in two groups, dichotomized by median age, showed that this effect was present in the younger half of the population. Limited evidence of effect modification by ALAD genotype was observed; higher blood lead levels were associated with higher calculated creatinine clearance among participants with the ALAD(1-2) genotype. In conclusion, VDR and/or ALAD genotypes modified associations between all the lead biomarkers, except patella lead, and the renal outcomes.

  18. Enhanced Activated Carbon Cathode Performance for Microbial Fuel Cell by Blending Carbon Black

    KAUST Repository

    Zhang, Xiaoyuan

    2014-02-04

    Activated carbon (AC) is a useful and environmentally sustainable catalyst for oxygen reduction in air-cathode microbial fuel cells (MFCs), but there is great interest in improving its performance and longevity. To enhance the performance of AC cathodes, carbon black (CB) was added into AC at CB:AC ratios of 0, 2, 5, 10, and 15 wt % to increase electrical conductivity and facilitate electron transfer. AC cathodes were then evaluated in both MFCs and electrochemical cells and compared to reactors with cathodes made with Pt. Maximum power densities of MFCs were increased by 9-16% with CB compared to the plain AC in the first week. The optimal CB:AC ratio was 10% based on both MFC polarization tests and three electrode electrochemical tests. The maximum power density of the 10% CB cathode was initially 1560 ± 40 mW/m2 and decreased by only 7% after 5 months of operation compared to a 61% decrease for the control (Pt catalyst, 570 ± 30 mW/m2 after 5 months). The catalytic activities of Pt and AC (plain or with 10% CB) were further examined in rotating disk electrode (RDE) tests that minimized mass transfer limitations. The RDE tests showed that the limiting current of the AC with 10% CB was improved by up to 21% primarily due to a decrease in charge transfer resistance (25%). These results show that blending CB in AC is a simple and effective strategy to enhance AC cathode performance in MFCs and that further improvement in performance could be obtained by reducing mass transfer limitations. © 2014 American Chemical Society.

  19. Nanodefects of membranes cause destruction of packed red blood cells during long-term storage

    Energy Technology Data Exchange (ETDEWEB)

    Kozlova, Elena, E-mail: waterlake@mail.ru [V.A. Negovsky Scientific Research Institute of General Reanimatology, Moscow (Russian Federation); I.M. Sechenov First Moscow State Medical University, Moscow (Russian Federation); Chernysh, Aleksandr [V.A. Negovsky Scientific Research Institute of General Reanimatology, Moscow (Russian Federation); I.M. Sechenov First Moscow State Medical University, Moscow (Russian Federation); Moroz, Victor; Sergunova, Victoria; Gudkova, Olga; Kuzovlev, Artem [V.A. Negovsky Scientific Research Institute of General Reanimatology, Moscow (Russian Federation)

    2015-10-01

    Packed red blood cells (PRBC) are used for blood transfusion. PRBC were stored for 30 days under 4 °C in hermetic blood bags with CPD anticoagulant-preservative solution. Hematocrit was 50–55%. The distortions of PRBC membranes nanostructure and cells morphology during storage were studied by atomic force microscopy. Basic measurements were performed at the day 2, 6, 9, 16, 23 and 30 of storage and additionally 2–3 days after it. Topological defects occurred on RBC membranes by day 9. They appeared as domains with grain-like structures (“grains”) sized up to 200 nm. These domains were appeared in almost all cells. Later these domains merged and formed large defects on cells. It was the formation of domains with the “grains” which was onset process leading eventually to destruction of PRBC. Possible mechanisms of transformation of PRBC and their membrane are related to the alterations of spectrin cytoskeleton. During this storage period potassium ions and lactat concentrations increased, pH decreased, intracellular concentration of reduced glutathione diminished in the preservative solution. Changes of PRBC morphology were detected within the entire period of PRBC storage. Discocytes predominated at the days 1 and 2. By day 30 PRBC transformed into irreversible echinocytes and spheroechinocytes. Study of defects of membranes nanostructure may form the basis of assessing the quality of the stored PRBC. This method may allow to work out the best recommendations for blood transfusion. - Highlights: • Domains with “grains” are formed on membranes surface on 9–16 days of PRBC storage. • The development of domains is the reason of irreversible changes of PRBC structure. • The origin of domains is the consequence of alterations of spectrin cytoskeleton. • Study of nanostructure may form basis of assessing the quality of the stored PRBC.

  20. Validity of a Minimally Invasive Autopsy for Cause of Death Determination in Adults in Mozambique: An Observational Study

    Science.gov (United States)

    Castillo, Paola; Martínez, Miguel J.; Ussene, Esperança; Jordao, Dercio; Lovane, Lucilia; Ismail, Mamudo R.; Carrilho, Carla; Lorenzoni, Cesaltina; Ferreira, Luiz; Lacerda, Marcus; Mandomando, Inacio; Vila, Jordi; Munguambe, Khátia; Maixenchs, Maria; Quintó, Llorenç; Macete, Eusebio; Alonso, Pedro; Bassat, Quique; Menéndez, Clara; Ordi, Jaume

    2016-01-01

    Background There is an urgent need to identify tools able to provide reliable information on the cause of death in low-income regions, since current methods (verbal autopsy, clinical records, and complete autopsies) are either inaccurate, not feasible, or poorly accepted. We aimed to compare the performance of a standardized minimally invasive autopsy (MIA) approach with that of the gold standard, the complete diagnostic autopsy (CDA), in a series of adults who died at Maputo Central Hospital in Mozambique. Methods and Findings In this observational study, coupled MIAs and CDAs were performed in 112 deceased patients. The MIA analyses were done blindly, without knowledge of the clinical data or the results of the CDA. We compared the MIA diagnosis with the CDA diagnosis of cause of death. CDA diagnoses comprised infectious diseases (80; 71.4%), malignant tumors (16; 14.3%), and other diseases, including non-infectious cardiovascular, gastrointestinal, kidney, and lung diseases (16; 14.3%). A MIA diagnosis was obtained in 100/112 (89.2%) cases. The overall concordance between the MIA diagnosis and CDA diagnosis was 75.9% (85/112). The concordance was higher for infectious diseases and malignant tumors (63/80 [78.8%] and 13/16 [81.3%], respectively) than for other diseases (9/16; 56.2%). The specific microorganisms causing death were identified in the MIA in 62/74 (83.8%) of the infectious disease deaths with a recognized cause. The main limitation of the analysis is that both the MIA and the CDA include some degree of expert subjective interpretation. Conclusions A simple MIA procedure can identify the cause of death in many adult deaths in Mozambique. This tool could have a major role in improving the understanding and surveillance of causes of death in areas where infectious diseases are a common cause of mortality. PMID:27875530

  1. New methodology to assess activity status of occlusal caries in primary teeth using laser fluorescence device

    Science.gov (United States)

    Braga, Mariana Minatel; Saveriano de Benedetto, Monique; Imparato, Jose Carlos Pettorossi; Mendes, Fausto Medeiros

    2010-07-01

    An in vivo study was conducted to verify the ability of laser fluorescence (LF) to assess the activity status of occlusal caries in primary teeth, using different air-drying times. Occlusal sites (707) were examined using LF (DIAGNOdent) after air-drying for 3 s and 15 s, and the difference between readings (DIF15 s-3 s) was calculated. For concurrent validation of LF, visual criteria-Nyvad (NY) and Lesion Activity Assessment associated with the International Caries Detection and Assessment System (LAA-ICDAS)-were the reference standards for lesion activity. Histological exam using a pH-indicator dye (0.1% methyl red) was performed in 46 exfoliated/extracted teeth for criterion validation. LF readings and DIF15 s-3 s were compared using Kruskall-Wallis and Mann-Whitney tests. Receiver operating characteristic analyses were performed and validity parameters calculated, considering the caries activity assessment. Using NY, active lesions (3 s: 30.0+/-29.3 15 s: 34.2+/-30.6) presented higher LF readings than inactive lesions (3 s: 17.0+/-16.3 15 s: 19.2+/-17.3 pcaries resulted in higher LF readings (3 s: 50.3+/-3.5 15 s: 54.7+/-30.2) than inactive cavitated caries (3 s: 19.9+/-16.3 15 s: 22.8+/-16.8). Therefore, LF can distinguish cavitated active and inactive lesions classified by NY, but not by LAA-ICDAS; however, this difference might be related to the visual system rather than to LF. The air-drying time could be an alternative to improve the caries activity assessment; however, longer air-drying time is suggested to be tested subsequently.

  2. Genesis Solar Wind Collector Cleaning Assessment: Update on 60336 Sample Case Study

    Science.gov (United States)

    Goreva, Y. S.; Allums, K. K.; Gonzalez, C. P.; Jurewicz, A. J.; Burnett, D. S.; Allton, J. H.; Kuhlman, K. R.; Woolum, D.

    2015-01-01

    To maximize the scientific return of Genesis Solar Wind return mission it is necessary to characterize and remove a crash-derived particle and thin film surface contamination. A small subset of Genesis mission collector fragments are being subjected to extensive study via various techniques. Here we present an update on the sample 60336, a Czochralski silicon (Si-CZ) based wafer from the bulk array (B/C). This sample has undergone multiple cleaning steps (see the table below): UPW spin wash, aggressive chemical cleanings (including aqua regia, hot xylene and RCA1), as well as optical and chemical (EDS, ToF-SIMS) imaging. Contamination appeared on the surface of 60336 after the initial 2007 UPW cleaning. Aqua regia and hot xylene treatment (8/13/2013) did little to remove contaminants. The sample was UPW cleaned for the third time and imaged (9/16/13). The UPW removed the dark stains that were visible on the sample. However, some features, like "the Flounder" (a large, 100 micron feature in Fig. 1b) appeared largely intact, resisting all previous cleaning efforts. These features were likely from mobilized adhesive, derived from the Post-It notes used to stabilize samples for transport from Utah after the hard landing. To remove this contamination, an RCA step 1 organic cleaning (RCA1) was employed. Although we are still uncertain on the nature of the Flounder and why it is resistant to UPW and aqua regia/hot xylene treatment, we have found RCA1 to be suitable for its removal. It is likely that the glue from sticky pads used during collector recovery may have been a source for resistant organic contamination [9]; however [8] shows that UPW reaction with crash-derived organic contamination does not make particle removal more difficult.

  3. A clinical index to predict progression from mild cognitive impairment to dementia due to Alzheimer's disease.

    Directory of Open Access Journals (Sweden)

    Sei J Lee

    Full Text Available Mild cognitive impairment is often a precursor to dementia due to Alzheimer's disease, but many patients with mild cognitive impairment never develop dementia. New diagnostic criteria may lead to more patients receiving a diagnosis of mild cognitive impairment.To develop a prediction index for the 3-year risk of progression from mild cognitive impairment to dementia relying only on information that can be readily obtained in most clinical settings.382 participants diagnosed with amnestic mild cognitive impairment enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI, a multi-site, longitudinal, observational study.Demographics, comorbid conditions, caregiver report of participant symptoms and function, and participant performance on individual items from basic neuropsychological scales.Progression to probable Alzheimer's disease.Subjects had a mean (SD age of 75 (7 years and 43% progressed to probable Alzheimer's disease within 3 years. Important independent predictors of progression included being female, resisting help, becoming upset when separated from caregiver, difficulty shopping alone, forgetting appointments, number of words recalled from a 10-word list, orientation and difficulty drawing a clock. The final point score could range from 0 to 16 (mean [SD]: 4.2 [2.9]. The optimism-corrected Harrell's c-statistic was 0.71(95% CI: 0.68-0.75. Fourteen percent of subjects with low risk scores (0-2 points, n = 124 converted to probable Alzheimer's disease over 3 years, compared to 51% of those with moderate risk scores (3-8 points, n = 223 and 91% of those with high risk scores (9-16 points, n = 35.An index using factors that can be obtained in most clinical settings can predict progression from amnestic mild cognitive impairment to probable Alzheimer's disease and may help clinicians differentiate between mild cognitive impairment patients at low vs. high risk of progression.

  4. Rubbly Pahoehoe: Implication for Flood Basalt Eruptions and their Atmospheric Effects

    Science.gov (United States)

    Keszthelyi, L.; Keszthelyi, L.; Thordarson, T.; Self, S.

    2001-12-01

    Rubbly pahoehoe flows consist of a brecciated flow top, a pahoehoe base, and an interior similar to inflated pahoehoe flows. Rubbly pahoehoe flows can be found in many localities, making up ~20% of the Columbia River Basalt Group, ~50% of the lavas drilled on the Kerguelen Plateau, and a substantial fraction of the Icelandic lava flows. They are rare in the tholeiitic shield portions of the Hawaiian volcanoes, but are more common in the alkalic flows. They also appear to be the dominant type of Martian flood lava flow. Based primarily on observations from the 1873-1874 Laki Flow Field in Iceland, we suggest that rubbly pahoehoe flows form when the flux of lava within an inflating pahoehoe flow is so large that it rafts away the upper crust. This crust is then broken into large slabs and fragmented lobes, intruded by liquid lava from below, and folded into pressure ridges. This brecciation process quickly builds an insulating crust; for the Laki case a crust >4 m thick developed in less than a week. This rapid formation of a thick insulating crust allows lava to be transported over great distances with minimal cooling in eruptions lasting only weeks-months. Flood basalt flows emplaced in this manner could have had eruption rates on the order of 104 - 105 m^{3}s^{-1}. If active fissure segments were of the order of 10 km long, the volcanic plumes should have risen 9-16 km -- penetrating the stratosphere in most cases. The injection of \\sim10 Gt of SO_{2}$, F, and Cl into the stratosphere could have had serious climatic effects, thus further strengthening the plausible link between flood basalt eruptions and mass extinctions.

  5. Chemical composition of components comprising bast tissue in flax.

    Science.gov (United States)

    Morrison, W H; Akin, D E

    2001-05-01

    Components from the bast region of flax (Linum usitatissium) were removed by hand from seed flax and fiber flax and analyzed by gas chromatography and mass spectrometry. Stems soaked in water were separated by hand into an outer layer, which consisted of epidermis with cuticle and parenchyma cells, and fiber bundles. Each of the two fractions were evaluated for chemical markers that could be used to predict the degree of retting and possibly fiber quality. The outer layer was subsequently treated with a mixed enzyme preparation to remove the carbohydrate portion, thus providing another fraction consisting primarily of cuticle. Four main constituent groups were investigated: dihydroxy fatty acids, long-chain fatty acids and alcohols, sterols, and aromatics. Long-chain fatty acids and alcohols located in the outer layer accounted for 80-92% of the total found in both fractions. Aromatics and sterols in the outer layer accounted for 29--72 and 27--67%, respectively, of the total and do not appear to be a reliable marker for the degree of retting. The best markers for retting were the dihydroxy fatty acids, of which 98--99% were accounted for in the outer layer. The main dihydroxy fatty acids were a mixture of 8,16- and 9,16-dihydroxyhexadecanoic acids and represented 87--89% of the total dihydroxy fatty acids measured. As a constituent of cuticle, this compound may serve as an excellent marker for indicating the degree of retting as well as a possible marker for fiber quality because this compound is almost always exclusively associated with the outer layer and not the fiber.

  6. Central Diabetes Insipidus in Infancy With or Without Hypothalamic Adipsic Hypernatremia Syndrome: Early Identification and Outcome.

    Science.gov (United States)

    Djermane, Adel; Elmaleh, Monique; Simon, Dominique; Poidvin, Amélie; Carel, Jean-Claude; Léger, Juliane

    2016-02-01

    Neonatal central diabetes insipidus (CDI) with or without adipsia is a very rare complication of various complex hypothalamic disorders. It is associated with greater morbidity and a high risk of developing both hypernatremia and hyponatremia, due to the condition itself or secondary to treatment with vasopressin analogs or fluid administration. Its outcomes have yet to be evaluated. To investigate the clinical outcomes of patients with neonatal-onset CDI or adipsic CDI with hypernatremia. All patients diagnosed with neonatal CDI in a university hospital-based observational study and followed between 2005 and 2015 were included and analyzed retrospectively. The various causes of CDI were grouped. Clinical outcome and comorbidities were analyzed. Ten of the 12 patients had an underlying condition with brain malformations: optic nerve hypoplasia (n = 3), septo-optic dysplasia (n = 2), semilobar holoprosencephaly (n = 1), ectopic neurohypophysis (n = 3), and unilateral absence of the internal carotid artery (n = 1). The other two were idiopathic cases. During the median follow-up period of 7.8 (4.9-16.8) years, all but one patient displayed anterior pituitary deficiency. Transient CDI was found in three (25%) patients for whom a posterior pituitary hyperintense signal was observed with (n = 2) and without (n = 1) structural hypothalamic pituitary abnormalities, and with no other underlying cerebral malformations. Patients with permanent CDI with persistent adipsia (n = 4) and without adipsia (n = 5) required adequate fluid intake and various doses of desamino-D-arginine-8-vasopressin. Those with adipsia were more likely to develop hypernatremia (45 vs 33%), hyponatremia (16 vs 4%) (P < .0001), and severe neurodevelopmental delay (P < .05) than those without adipsia. Comorbidities were common. The underlying cause remains unknown at the age of 23 years for one patient with CDI and normal thirst. Neonatal CDI may be transient or permanent. These vulnerable patients have

  7. Magnitude and management of metabolic syndrome in Spain in 2008-2010: the ENRICA study.

    Science.gov (United States)

    Guallar-Castillón, Pilar; Pérez, Raúl Francisco; López García, Esther; León-Muñoz, Luz M; Aguilera, M Teresa; Graciani, Auxiliadora; Gutiérrez-Fisac, Juan Luis; Banegas, José R; Rodríguez-Artalejo, Fernando

    2014-05-01

    Few studies in Spain have reported the distribution of metabolic syndrome using the harmonized definition and that of premorbid metabolic syndrome, which consists of metabolic syndrome without diabetes mellitus or cardiovascular disease. Moreover, their regional distributions and clinical management are unknown. The present study examined the distributions and clinical management of both syndromes in Spain. This cross-sectional study was performed from 2008 to 2010 in 11 149 representative individuals of the Spanish population aged 18 years or older. Data were obtained through standardized physical examination, and analytical measurements were done in a central laboratory. The prevalences (95% confidence interval) of metabolic syndrome and premorbid metabolic syndrome were 22.7% (21.7%-23.7%) and 16.9% (16.0%-17.8%), respectively. The frequency of both syndromes increased with age and was higher in men than in women up to 65 years; above this age, the frequency was higher in women. The communities of the south of Spain and the Balearic and Canary islands had the highest prevalence of both syndromes, in some regions reaching double that of the community with the lowest prevalence. About one third of patients with premorbid metabolic syndrome reported that they had not received health recommendations to improve their lifestyles; of those that did receive advice, adherence was low, particularly for reducing weight (31.9%) and salt intake (38.3%). The prevalence of metabolic syndrome is high in Spain and considerable geographical differences exist in its distribution. There is substantial room for improvement in the clinical management of premorbid metabolic syndrome. Copyright © 2013 Sociedad Española de Cardiología. Published by Elsevier Espana. All rights reserved.

  8. The comparative study of MR perfusion-weighted imaging and 1H-MR spectroscopy in diagnosing soft tissue tumors

    International Nuclear Information System (INIS)

    Zhang Li'na; Wang Shaowu; Song Qingwei; Sun Meiyu

    2008-01-01

    Objective: To evaluate multiple magnetic resonance (MR) imaging techniques in the differentiation of benign and malignant soft tissue tumors by comparing different information from MR perfusion-weighted Imaging (MR-PWI) and 1 HMR spectroscopy ( 1 H-MRS). Methods: Forty patients with soft tissue tumors underwent conventional MR imaging, dynamic contrast-enhanced T 2 * -weighted MR-PWI and 1 H proton MR spectroscopy. The differences of perfusion and 1 H-MRS parameters of benign and malignant tumors were analyzed with t test. Results: There was significant difference between benign and malignant tumoral tissues of BF value and Cho/Cr ratio (t=2.531, 2.927, P -1 ·min -1 , sensitivity and specificity for determining malignant tumors were 81.8% (18/22), 72.2% (13/18), respectively. When the threshold value of Cho/Cr ratio was 3.22, Sensitivity and specificity for determining malignant tumors were 86.4% (19/22), 88.9% (16/18), respectively. The abnormal wave crest is detected at 2.0-2.1 ppm in 5 malignant tumors (2 malignant schwannoma and 3 malignant fibrous histiocytoma), while the other 55 cases were not. Conclusion: The BF value and Cho/Cr ratio were both valuable diagnostic parameters in differentiating benign and malignant soft tissue tumors. TIC was helpful to distinguish malignant tumors from benign tumors, while the sensitivity and specificity of 1 H-MRS in diagnosing malignant soft tissue tumors were both higher. (authors)

  9. Magnetic resonance imaging - guided vacuum-assisted breast biopsy: an initial experience in a community hospital

    International Nuclear Information System (INIS)

    Friedman, P.; Enis, S.; Pinyard, J.

    2009-01-01

    To evaluate the effectiveness in diagnosing mammographically and sonographically occult breast lesions by using magnetic resonance imaging (MRI) guided vacuum-assisted breast biopsy in patients who presented to a community-based hospital with a newly established breast MRI program. The records of 142 consecutive patients, median age of 55 years, who had undergone MRI-guided biopsy at our institution between July 2006 and July 2007 were reviewed. From these patients, 197 mammographically and sonographically occult lesions were biopsied at the time of discovery. The pathology was then reviewed and correlated with the MRI findings. Cancer was present and subsequently discovered in 8% of the previously occult lesions (16/197) or 11% of the women studied (16/142). Of the cancerous lesions, 56% were invasive carcinomas (9/16) and 44% were ductal carcinomas in situ (7/16). Fourteen percent of the discovered lesions (28/197) were defined as high risk and included atypical ductal hyperplasia, atypical lobular hyperplasia, lobular carcinoma in situ, and radial scar. In total, occult cancerous and high-risk lesions were discovered in 22% of the found lesions (44/197) or 31% of the women who underwent MRI-guided biopsy (44/142). This study demonstrated that detection of cancerous and high-risk lesions can be significantly increased when an MRI-guided biopsy program is introduced at a community-based hospital. We believe that as radiologists gain confidence in imaging and histologic correlation, community-based hospitals can achieve similar rates of occult lesion diagnosis as those found in data emerging from academic institutions. (author)

  10. Magnetic resonance imaging - guided vacuum-assisted breast biopsy: an initial experience in a community hospital

    Energy Technology Data Exchange (ETDEWEB)

    Friedman, P.; Enis, S.; Pinyard, J., E-mail: jpinyard@gmail.com [Morristown Memorial Hospital, The Carol W. and Julius A. Rippel Breast Center, The Carol G. Simon Cancer Centre, Morristown, New Jersey (United States)

    2009-10-15

    To evaluate the effectiveness in diagnosing mammographically and sonographically occult breast lesions by using magnetic resonance imaging (MRI) guided vacuum-assisted breast biopsy in patients who presented to a community-based hospital with a newly established breast MRI program. The records of 142 consecutive patients, median age of 55 years, who had undergone MRI-guided biopsy at our institution between July 2006 and July 2007 were reviewed. From these patients, 197 mammographically and sonographically occult lesions were biopsied at the time of discovery. The pathology was then reviewed and correlated with the MRI findings. Cancer was present and subsequently discovered in 8% of the previously occult lesions (16/197) or 11% of the women studied (16/142). Of the cancerous lesions, 56% were invasive carcinomas (9/16) and 44% were ductal carcinomas in situ (7/16). Fourteen percent of the discovered lesions (28/197) were defined as high risk and included atypical ductal hyperplasia, atypical lobular hyperplasia, lobular carcinoma in situ, and radial scar. In total, occult cancerous and high-risk lesions were discovered in 22% of the found lesions (44/197) or 31% of the women who underwent MRI-guided biopsy (44/142). This study demonstrated that detection of cancerous and high-risk lesions can be significantly increased when an MRI-guided biopsy program is introduced at a community-based hospital. We believe that as radiologists gain confidence in imaging and histologic correlation, community-based hospitals can achieve similar rates of occult lesion diagnosis as those found in data emerging from academic institutions. (author)

  11. Effects of nonsurgical periodontal therapy in patients with moderately controlled type 2 diabetes mellitus and chronic periodontitis in Nepalese population

    Science.gov (United States)

    Goel, Khushboo; Pradhan, Shaili; Bhattarai, Madhur Dev

    2017-01-01

    Objectives Despite several investigations, evidence is still controversial regarding the effect of periodontal treatment on diabetes. This study evaluates and compares the effect on glycemic control and periodontal status with or without nonsurgical periodontal therapy in patients with type 2 diabetes mellitus and chronic periodontitis in a Nepalese population. Materials and methods A total of 82 patients attending the diabetes clinic and fulfilling enrollment criteria with moderate to severe periodontitis were selected. They were assigned in an alternative sequence, into test and control group. Both groups were instructed to continue with their medical treatment without modifications. Scaling and root surface debridement were performed in the test group whereas the control group received oral hygiene instructions with no treatment during the 3-month study period. Results There were 41 participants in each group with the mean age of 50.66±7.70 and 53.80±9.16 years, average diabetes duration of 6.32±4.21 and 6.24±4.00 years, mean body mass index of 24.78±1.85 and 24.6±1.79 kg/m2, and glycated hemoglobin (HbA1c) level of 6.71±0.50% and 6.80±0.45%, in the test and control group, respectively. After 3 months, there was significant reduction in HbA1c levels in the test group compared to the control group (p=0.029). Clinical periodontal parameters of gingival index, probing depth (PD), and clinical attachment level (CAL) significantly improved in the test group (p0.001) who showed an increase by 0.05 mm. Conclusion This study showed that nonsurgical periodontal therapy may have a beneficial effect on HbA1c level in moderately controlled type 2 diabetic patients. PMID:28761379

  12. Meta-analysis of endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor agents: causative organisms and possible prevention strategies.

    Science.gov (United States)

    McCannel, Colin A

    2011-04-01

    To report the rates of endophthalmitis and the spectrum of causative organisms after intravitreal injection of anti-vascular endothelial growth factor agents and possible prevention strategies. Meta-analysis of the U.S. literature from 2005 to 2009 reporting endophthalmitis bacterial isolates after intravitreal injection of anti-vascular endothelial growth factor agents and comparison with reports of endophthalmitis bacterial isolates after intraocular surgery in the United States. Endophthalmitis after intravitreal injection occurred in 52 of 105,536 injections (0.049%) (95% confidence interval [CI], 0.038-0.065%). Among 50 cases of endophthalmitis with bacterial culture isolates, 24 (48.0% [95% CI, 34.8-61.5%]) were culture negative and 26 (52% [95% CI, 38.5-65.2%]) were culture positive. Among the 26 culture-positive isolates, causative organisms were coagulase-negative Staphylococcus in 17 cases (65.4% [95% CI, 46.0-80.6%]), Streptococcus species in 8 cases (30.8% [95% CI, 16.5-50.2%]), and Bacillus cereus in 1 case (3.8% [95% CI, 0.9-19.0%]). Streptococcus species were significantly more frequent after intravitreal injection than after intraocular surgery in the Endophthalmitis Vitrectomy Study (29 of 226 isolates, 9.0% [95% CI, 6.3-12.6%], P = 0.005), a report on clear corneal cataract surgery endophthalmitis (6 of 73 isolates, 8.2% [95% CI, 3.9-16.8%], P = 0.022), and a report on postvitrectomy endophthalmitis with no cases of Streptococcus species. Streptococcal isolates are approximately three times more frequent after intravitreal anti-vascular endothelial growth factor injection than after intraocular surgery. Strategies to consider minimizing oropharyngeal droplet transmission may include avoiding talking, coughing, and sneezing or wearing surgical masks.

  13. Periocular capillary hemangioma: management practices in recent years

    Directory of Open Access Journals (Sweden)

    Hernandez JA

    2013-06-01

    Full Text Available Jo Anne Hernandez,1,3,4 Audrey Chia,2 Boon Long Quah,1,2 Lay Leng Seah1,2 1Department of Ophthalmology, Kandang Kerbau Women's and Children's Hospital, Singapore; 2Singapore National Eye Centre, Singapore; 3National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore; 4Department of Ophthalmology, Cardinal Santos Medical Center, San Juan, Manila, Philippines Purpose: To present a case series on the management options for capillary hemangiomas involving the eyelid and orbit. Methods: This is a retrospective chart review of clinically diagnosed capillary hemangioma cases involving the periocular region treated at two local eye institutions. The patients' demographics and clinical presentation – including visual acuity, refractive error, periorbital and orbital examinations, and ultrasound and magnetic resonance imaging findings – were reviewed. The clinical progression, modalities of treatment, and treatment outcomes were studied. Results: Sixteen cases of capillary hemangiomas involving the eyelid and orbit were studied. The mean age at consultation was 9.6 months (range: 1 month–72 months. The majority were females (75%, with 50% presenting as upper-eyelid hemangiomas and the remaining as lower-eyelid (38% and glabellar (12% lesions. Combined superficial and deep involvement was common (64%. Cases whose lesions were located at the upper eyelid or superior orbit led to amblyopia (25%. Fifty-six percent of cases (9/16 were managed conservatively, and 44% (7/16 underwent treatment with either single-agent (n = 4 or combined treatments (n = 3. Conclusion: Close monitoring of visual development and prompt institution of amblyopia therapy for children with periocular capillary hemangiomas generally preserve vision. Extensive lesions that affect the visual axis require local and systemic treatments, alone or in combination, in order to reduce the size and impact of lesions on the eyeball, to reduce induced refractive error and

  14. Solvent hold tank sample results for MCU-16-53-55. January 2016 Monthly sample

    Energy Technology Data Exchange (ETDEWEB)

    Fondeur, F. F. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Jones, D. H. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2016-03-28

    Savannah River National Laboratory (SRNL) received one set of Solvent Hold Tank (SHT) samples (MCU-16-53-54-55), pulled on 01/25/2016 for analysis. The samples were combined and analyzed for composition. Analysis of the composite sample MCU-16-53-54-55 indicated the Isopar™L, and MaxCalix are at nominal levels. The modifier and TiDG concentrations are 3% and 23 % below their nominal concentrations. This analysis confirms the addition of TiDG, MaxCalix, and modifier to the solvent on November 28, 2015. Based on the current monthly sample, the levels of TiDG, Isopar™L, MaxCalix, and modifier are sufficient for continuing operation but are expected to decrease with time. Periodic characterization and trimming additions to the solvent are recommended. No impurities above the 1000 ppm level were found in this solvent by the Semi-Volatile Organic Analysis (SVOA). No impurities were observed in the Hydrogen Nuclear Magnetic Resonance (HNMR). However, the Fourier transform infra-red spectroscopy (FTIR) method detected trace levels (a few ppm) of amides (a possible degradation product of TiDG). In addition, up to 21 ± 4 micrograms of mercury per gram of solvent (or 17.5 μg/mL) was detected in this sample. There appears to be a possible correlation between the mercury level and the TiDG concentration in the solvent. The current gamma level (9.16 E4 dpm/mL) confirmed that the gamma concentration has returned to previous level where the process operated normally and as expected. The laboratory will continue to monitor the quality of the solvent in particular for any new impurities or degradation of the solvent components.

  15. [Acute Chagas' disease: transmission routes, clinical aspects and response to specific therapy in diagnosed cases in an urban center].

    Science.gov (United States)

    Shikanai-Yasuda, M A; Lopes, M H; Tolezano, J E; Umezawa, E; Amato Neto, V; Barreto, A C; Higaki, Y; Moreira, A A; Funayama, G; Barone, A A

    1990-01-01

    The authors report clinical features and therapeutic response of 24 outpatients with acute Chagas' disease, and 3 in the initial chronic phase, referred to the Clinic for Infectious and Parasitic Diseases of the FMUSP "Clínicas" Hospital between 1974 and 1987. The following transmission routes were involved: triatominae in 7 cases, blood transfusion in 9, kidney transplantation and/or blood transfusion in 4, accidental in 1, oral route in 3, probably breast feeding in 1, congenital or breast feeding in 1, and congenital or blood transfusion in 1. Six patients infected by triatominac acquired the disease between 1974 and 1980 and one in 1987. The blood transfusion infected patients acquired the disease in Greater São Paulo, seven of whom after 1983. The acute phase Chagas' disease was oligosymptomatic in 4 patients: three of such patients being immunocompromised by drugs or other diseases. Another two adult immunocompromised patients developed myocarditis and congestive heart failure. Clinical features were severe in 5 from 6 children under two years, irrespective of the transmission route. Evaluation of the acute phase patients treated with benznidazol (4-10 mg/kg/day) showed: therapeutic failure in 4/16 (25.0%); possible cure in 9/16 (53.2%) and inconclusive results in 3/16 (18.8%). The antibody and complement-mediated lysis reaction was in keeping with the xenodiagnosis in 18/22 cases, having shown negative results after treatment earlier than classical serological reactions. One aplastic anaemia patient receiving corticosteroid presented lymphoproliferative disease 6 years after being treated with benznidazol for acute Chagas' disease.

  16. Prosthetic hip dislocations: is relocation in the emergency department by emergency medicine staff better?

    Science.gov (United States)

    Lawrey, Emma; Jones, Peter; Mitchell, Robin

    2012-04-01

    Prosthetic hip dislocation is common. This study compares prosthetic hip relocations attempted within the ED by emergency doctors and those under orthopaedic care in the ED or operating theatre (OT). Retrospective cohort study of patients presenting to Auckland City Hospital Adult Emergency Department with prosthetic hip dislocations between 1 January 2003 and 14 April 2008. Primary outcomes were proportion of successful relocation attempts and length of hospital stay. Secondary outcomes were: time to relocation, complications, post-procedural advice, representation rate and long-term outcomes for first-time dislocations. There were 410 eligible presentations during the study period. Emergency medicine (EM) was successful in 254/323 attempts (79%, 95% confidence interval [CI] 74-83). Orthopaedics were successful in 25/35 reductions in the ED (71%, 95% CI 55-84) and 49/51 OT attempts (96%, 95% CI 86-100), P = 0.004 for location OT versus ED. Median times to discharge were 8.8 h for EM, 28.3 h for orthopaedics in the ED and 81 h for orthopaedics in the OT, P < 0.001 for EM versus orthopaedics. Mechanical complications of procedures and early redislocations were infrequent. Complication of sedation were more often seen in OT compared to ED (23/47 [49%, 95% CI 35-63]vs 37/318 [12%, 95% CI 9-16]). There was no difference between EM and orthopaedics in the proportion of hips successfully relocated or complications in the ED; however, EM patients were discharged much sooner, with important resource implications. Procedures carried out in the OT were more successful than in the ED but resulted in prolonged hospital stays and were associated with more complications. © 2012 The Authors. EMA © 2012 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine.

  17. Educational Utility of Advanced 3-Dimensional Virtual Imaging in Evaluating the Anatomical Configuration of the Frontal Recess

    Science.gov (United States)

    Agbetoba, Abib; Luong, Amber; Siow, Jin Keat; Senior, Brent; Callejas, Claudio; Szczygielski, Kornel; Citardi, Martin J.

    2016-01-01

    Introduction Endoscopic sinus surgery represents a cornerstone in the professional development of otorhinolaryngology trainees. Mastery of these surgical skills requires an understanding of paranasal sinus and skull base anatomy. The frontal sinus is associated with a wide range of variation and complex anatomical configuration, and thus represents an important challenge for all trainees performing endoscopic sinus surgery. Methods Forty-five otorhinolaryngology trainees and 20 medical school students from five academic institutions were enrolled and randomized into 1 of 2 groups. Each subject underwent learning of frontal recess anatomy with both traditional 2D learning methods using a standard DICOM viewing software (RadiAnt Dicom Viewer Version 1.9.16) and 3D learning utilizing a novel preoperative virtual planning software (Scopis Building Blocks), with half learning with the 2D method first and the other half learning with the 3D method first. Four questionnaires that included a total of twenty items were scored for subjects’ self-assessment on knowledge of frontal recess and frontal sinus drainage pathway anatomy following each learned modality. A two-sample Wilcoxon rank-sum test was used in the statistical analysis comparing the 2 groups. Results Most trainees (89%) believed that the virtual 3D planning software significantly improved their understanding of the spatial orientation of the frontal sinus drainage pathway. Conclusion Incorporation of virtual 3D planning surgical software may help augment trainees understanding and spatial orientation of the frontal recess and sinus anatomy. The potential increase in trainee proficiency and comprehension theoretically may translate to improved surgical skill and patient outcomes and in reduced surgical time. PMID:27754596

  18. Somatostatin receptor scintigraphy in advanced renal cell carcinoma. Results of a phase II-trial of somatostatine analogue therapy in patients with advanced RCC

    International Nuclear Information System (INIS)

    Freudenberg, L.S.; Goerges, R.; Stergar, H.; Bockisch, A.; Gauler, T.; Bauer, S.; Antoch, G.; Schuette, J.

    2008-01-01

    Aims: objective of this prospective study was to evaluate the role of somatostatin receptor scintigraphy (SRS) in advanced renal cell carcinoma (RCC) with respect to potential therapy with somatostatin analogue (SST-A) and to assess the response rate under therapy with SST-A. Patients, methods: 16 patients with documented progression of histologically confirmed advanced RCC were included. Planar whole-body SRS was performed 4, 24 and 48h post i.v. injection of 175-200 MBq 111 In-pentetreoide. 5 and 25 h p.i. SPECT of thorax and abdomen were performed. Documentation of somatostatin receptor expression via SRS in > 50% of known tumour lesions was the criteria for treatment start with SST-A (Sandostatin LAR registered -Depot 30mg i.m. every four weeks). Results: in 9/16 of the patients SRS showed at least one metastasis with moderate (n = 5) or intense (n = 4) tracer uptake. Lesion-based SRS evaluation showed only 12.1% (20/165) of all metastases. Most false-negative lesions were located in the lungs. In too patients, the majority of the known metastases was SRS positive and these patients received SST-A therapy. The first radiographic evaluation after a two-month interval showed progressive disease in both patients. Conclusions: we conclude that SRS is of limited value in staging of advanced RCC. In our patients SST-A did not result in a growth control of RCC. Consequently, the use of SST-A in advanced RCC seems to be no relevant therapeutic option. (orig.)

  19. Geopolymer Mortar with Fly Ash

    Directory of Open Access Journals (Sweden)

    Saloma

    2016-01-01

    Full Text Available The cement industry accounts for about 7% of all CO2 emissions caused by humans. Therefore, it is necessary to find another material in order to support sustainable material. An alternative way is replacing cement material with alternative material as fly ash. Fly ash as binder need to be added alkaline activator in the form of sodium silicate (Na2SiO3 or potassium silicate (K2SiO3 and sodium hydroxide (NaOH or potassium hydroxide (KOH. The purpose of this research is to analyze the effect of activator liquid concentration on geopolymer mortar properties and to know the value of compressive strength. Molarity variation of NaOH are 8, 12, 14, and 16 M with ratio of Na2SiO3/NaOH = 1.0. Ratio of sand/fly ash = 2.75 and ratio of activator/fly ash = 0.8. The cube-shaped specimen 50 × 50 × 50 mm is cured by steam curing with a temperature of 60°C for 48 hours. The experimental result of fresh mortar reported that the molarity of NaOH affect the slump flow and setting time, higher of NaOH produces the smaller value of slump and the faster time of setting. The experimental of density results reported that the increase of specific gravity when the molarity of NaOH increased. The experimental results of the compressive strength are showed that the maximum compressive strength of geopolymer mortar 14 M is 10.06 MPa and the lowest compressive strength produced by geopolymer mortar 8 M is 3.95 MPa. Testing the compressive strength of geopolymer mortar 16 M produces compressive strength lower than 14 M geopolymer mortar is 9.16 MPa.

  20. Neuromuscular electrical stimulation and the treatment of lower urinary tract dysfunction in multiple sclerosis--a double blind, placebo controlled, randomised clinical trial.

    Science.gov (United States)

    McClurg, D; Ashe, R G; Lowe-Strong, A S

    2008-01-01

    Lower urinary tract dysfunction affects up to 75% of the multiple sclerosis population. Results from our recent Pilot Study (McClurg et al., 2006) indicated that a combined programme of pelvic floor muscle training, electromyography biofeedback and neuromuscular electrical stimulation modalities may alleviate some of the distressing symptoms within this population. This clinical trial aimed to evaluate further the efficacy of these interventions and to establish the benefit of neuromuscular electrical stimulation above and beyond that of EMG biofeedback and pelvic floor muscle training. 74 multiple sclerosis patients who presented with lower urinary tract dysfunction were randomly allocated to one of two groups - Group 1 received Pelvic Floor Muscle Training, Electromyography Biofeedback and Placebo Neuromuscular Electrical Stimulation (n=37), and Group 2 which received Pelvic Floor Muscle Training, Electromyography Biofeedback, and Active Neuromuscular Electrical Stimulation (n=37). Treatment was for nine weeks with outcome measures recorded at weeks 0, 9, 16 and 24. The Primary Outcome Measure was the number of leakage episodes. Within group analysis was by Paired Samples t-test. Group differences were analysed using Repeated Measures Analysis of Variance and Post-hoc tests were used to determine the significance of differences between Groups at each time point. The mean number of incontinence episodes were reduced in Group 2 by 85% (p=0.001) whereas in Group 1 a lesser reduction of 47% (p=0.001) was observed. However, there was a statistically superior benefit in Group 2 when compared to Group 1 (p=0.0028). This superior benefit was evident in all other outcome measures. The addition of Active Neuromuscular Electrical Stimulation to a programme of Pelvic Floor Muscle Training and Electromyography Biofeedback should be considered as a first-line option in alleviating some of the symptoms of lower urinary tract dysfunction associated with multiple sclerosis. (c

  1. Optimising diffusion-weighted MR imaging for demonstrating pancreatic cancer: a comparison of respiratory-triggered, free-breathing and breath-hold techniques

    International Nuclear Information System (INIS)

    Kartalis, Nikolaos; Loizou, Louiza; Edsborg, Nick; Albiin, Nils; Segersvaerd, Ralf

    2012-01-01

    To compare respiratory-triggered, free-breathing, and breath-hold DWI techniques regarding (1) image quality, and (2) signal intensity (SI) and ADC measurements in pancreatic ductal adenocarcinoma (PDAC). Fifteen patients with histopathologically proven PDAC underwent DWI prospectively at 1.5 T (b = 0, 50, 300, 600 and 1,000 s/mm 2 ) with the three techniques. Two radiologists, independently and blindly, assigned total image quality scores [sum of rating diffusion images (lesion detection, anatomy, presence of artefacts) and ADC maps (lesion characterisation, overall image quality)] per technique and ranked them. The lesion SI, signal-to-noise ratio, mean ADC and coefficient of variation (CV) were compared. Total image quality scores for respiratory-triggered, free-breathing and breath-hold techniques were 17.9, 16.5 and 17.1 respectively (respiratory-triggered was significantly higher than free-breathing but not breath-hold). The respiratory-triggered technique had a significantly higher ranking. Lesion SI on all b-values and signal-to-noise ratio on b300 and b600 were significantly higher for the respiratory-triggered technique. For respiratory-triggered, free-breathing and breath-hold techniques the mean ADCs were 1.201, 1.132 and 1.253 x 10 -3 mm 2 /s, and mean CVs were 8.9, 10.8 and 14.1 % respectively (respiratory-triggered and free-breathing techniques had a significantly lower mean CV than the breath-hold technique). In both analyses, respiratory-triggered DWI showed superiority and seems the optimal DWI technique for demonstrating PDAC. (orig.)

  2. Pre- and postnatal tobacco and cannabis exposure and child behavior problems: Bidirectional associations, joint effects, and sex differences.

    Science.gov (United States)

    Eiden, Rina D; Zhao, Junru; Casey, Meghan; Shisler, Shannon; Schuetze, Pamela; Colder, Craig R

    2018-02-05

    We examined prospective associations between pre-and-postnatal tobacco and cannabis exposure on child behavior problems from 2 to 3 years of child age, sex differences in these associations, and bidirectional associations between maternal postnatal substance use and child behavior problems across time. The sample consisted of 247 primarily young, unmarried, low-income, minority mothers and their children (97 prenatally exposed to tobacco and cannabis, 81 exposed to tobacco only, and 69 non-exposed). Mothers were assessed during each trimester of pregnancy, at 2, 9, 16 months, 2 and 3 years of child age. Bivariate results indicated significant differences mainly for girls. Girls in the prenatal tobacco exposure group had higher internalizing problems compared to the other two groups, and higher attention and sleep problems at 3 years compared to the control group. Higher number of cigarettes per day during pregnancy was significantly associated with higher anxiety/depression and higher attention problems at 3 years, and the associations were stronger for girls compared to boys. In model testing controlling for prenatal exposure, results indicated bidirectional associations between behavior problems at 2 years and maternal postnatal cannabis use, such that higher cannabis use across the infant toddler period predicted higher behavior problems at 2 years, which in turn predicted higher cannabis use a year later. Results add to the literature on joint effects of tobacco and cannabis, highlight the importance of considering bidirectional associations between maternal substance use and child behavior problems, and indicate generally stronger prenatal tobacco exposure effects for girls. Copyright © 2018 Elsevier B.V. All rights reserved.

  3. Increased risk of second malignant neoplasms in adolescents and young adults with cancer.

    Science.gov (United States)

    Lee, Jean S; DuBois, Steven G; Coccia, Peter F; Bleyer, Archie; Olin, Rebecca L; Goldsby, Robert E

    2016-01-01

    The authors describe the incidence and characteristics of secondary malignant neoplasms (SMNs) in adolescent and young adult (AYA) cancer survivors compared with those in younger and older cancer survivors. Children aged ≤ 14 years, AYAs aged 15 to 39, and older adults aged ≥ 40 years at the time of primary diagnosis who were reported as cancer survivors in the Surveillance, Epidemiology, and End Results (SEER) program between 1973 and 2011 were compared in this population-based analysis. The primary analysis was the risk that an SMN would occur ≥ 5 years after the original diagnosis for patients who had the more common AYA cancers (leukemia, lymphoma, testicular malignancy, ovarian malignancy, melanoma, and cancers of the thyroid, breast, soft tissue, or bone). The standardized incidence ratio (SIR), absolute excess risk (AER), and cumulative incidence of SMN for the selected cancers were assessed. The risk of SMN for the entire cohort also was analyzed. Of the 148,558 AYA survivors who were diagnosed with a selected cancer, 7384 developed an SMN 5 years after their original diagnosis. The SIRs (95% confidence intervals [CIs]) were 1.58 (95% CI, 1.55-1.62) for AYAs, 4.26 (95% CI, 3.77-4.80) for children, and 1.10 (95% CI, 1.09-1.11) for older adults, and the AERs were 22.9, 16.6, and 14.7, respectively. The cumulative incidence of SMN at 30 years was 13.9% for the AYA group. The most common SMNs in AYAs were breast cancer, gastrointestinal cancer, genital cancers, and melanoma. AYAs who had received radiation therapy had a higher cumulative incidence of SMN. AYAs who survive cancer for more than 5 years have a higher relative risk of SMN compared with the general population and have a higher absolute risk of SMN compared with younger or older cancer survivors. © 2015 American Cancer Society.

  4. Interventional Bronchoscopy for the Treatment of Pulmonary Sarcoma

    Directory of Open Access Journals (Sweden)

    Hongwu WANG

    2016-09-01

    Full Text Available Background and objective Pulmonary sarcoma is a rare malignant tumor in soft tissues. Resection is the preferred option to treat this tumor. The aim of this study is to explore the effect of interventional bronchoscopies in the treatment of pulmonary sarcoma if the patient is inoperable. Methods Sixteen cases with pulmonary sarcoma were retrospectively reviewed in our hospital from November 2008 to July 2014. The mean age was (53.1±5.4 years old. Rigid bronchoscopy was applied for the first procedure with general anesthesia, and electronic bronchoscopy was used for the second procedure or slight patients. Results Sixteen cases, which include 10 sarcomatoid carcinoma, 2 fibrosarcoma, 2 sarcoma, 1 fibromucoid sarcoma, and 1 spindle cell synovial sarcoma, were collected in this study. Eleven cases (68.8% were peripheral and mainly located in the right upper lobe and left lower lobe. Five cases (31.2% were central. Of these cases, 82% (9/11 were mixed and primary tumors in pulmonary tumor. Meanwhile, 56% (9/16 were intraluminal and 69% (11/16 were metastatic in central airway. All of the four cases with whole atelectasis were completely relieved through postbronchoscopic interventions. Three of the seven cases with segment atelectasis were completely reopened; two of them were partially relieved; and the remaining two had no response. The obstructive degree, Karnofsky performance status (KPS, and shortness of breathless score improved significantly after the treatment. Conclusion Interventional bronchoscopy could rapidly and efficiently remove endobronchial tumor, relieve airway obstruction, and improve clinical symptoms.

  5. In-vitro fermentation characteristics and methane reduction potential of mustard cake (Brassica juncea L.

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    S. M. Durge

    2016-10-01

    Full Text Available Aim: To assess the effect of mustard cake (Brassica juncea L. levels in concentrate mixtures and in composite feed mixtures (CFMs on in-vitro fermentation characteristics and methane production. Materials and Methods: Five concentrate mixtures were prepared with containing 30% oil cake, where linseed cake was replaced by mustard cake at the rate of 0%, 7.5%, 15.0%, 22.5%, and 30% in concentrate mixture. Mustard cake contained glucosinolate 72.58 μmol/g oil free dry matter (DM and contents in diet were 0, 5.4, 10.9, 16.3, and 21.8 μmol/g of concentrate mixture, respectively. Concentrate mixture containing 15.0% mustard cake was found to produced minimum methane which was then used for the preparation of CFM containing 0%, 25%, 50%, and 75% levels with gram straw. Result: Increased levels of mustard cake in concentrate mixtures had a linear decrease (p<0.05 in the total gas production, and the 15% inclusion showed lowest methane concentration (quadratic, p<0.01. The degradability of DM and organic matter (OM of concentrate mixtures did not change, however, pH and NH3-N concentrations of the fermentation medium showed linear (p<0.05 reductions with increased mustard cake levels. Increased levels of 15% mustard cake containing concentrate mixture in CFMs exhibited a trend (p=0.052 of increased gas production, whereas methane concentration in total gas, methane produced and degradability of DM and OM were also displayed a linear increase (p<0.05. However, the pH, NH3-N, and total volatile fatty acid levels decreased linearly (p<0.05 with increased levels of concentrate in CFMs. Conclusion: Reduction in methane production was evidenced with the inclusion of mustard cake in concentrate mixture at 15% level, and the CFMs with 25% concentrate, which contained 15% mustard cake, exhibited an improved fermentation and reduced methane production.

  6. Remembering and constructing Israelite identity in postexilic Yehud: Some remarks on the penitential prayer of Nehemiah 9:6�37

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    V. Ndikhokele N. Mtshiselwa

    2016-03-01

    Full Text Available That there is a growing focus and elaboration of prayers in the Old Testament scholarship on the postexilic biblical writings suggests that such prayers received an authoritative status in postexilic Yehud. Firstly, this paper argues that not only did the remembrance of the story of Israel confer an authoritative status to Nehemiah 9:6�37, it also served the purpose of casting a hopeful and prophetic imagination of a liberated community in Yehud. Secondly, it is argued in this paper that the prayer of Nehemiah 9:6�37 shaped the identity of the Jews in Yehud amidst socio-economic injustices. This identity was linked to the patriarch Abraham (cf. Neh 9:7�8, to the liberation of the Jews from Pharaoh under the leadership of Moses (cf. Neh 9:9�15, 21, to the possession of the Promised Land (cf. Neh 9:22�25, to the caution about the consequence of disobedience to Yahweh � the exile (cf. Neh 9:16�21, 26�30- and to the demise of the kingdom in the Babylonian exile (cf. Neh 9:31�37. On the whole, it is argued in this paper that the prayer of Nehemiah 9:6�37 was composed and transmitted with the view to remember and construct the identity of the Jews in postexilic Yehud.Intradisciplinary and/or interdisciplinary implications: Not only does this article explore the religious aspect of Nehemiah 9:6�37, it equally investigates the socio-economic and political undertones in the text in order to determine the context from which the penitential prayer emerged. It is argued here that in the postexilic Yehud context, Nehemiah 9:6�37 served to remember and construct the identity of the Jews.Keywords: Nehemiah; story of Israel; identity construction; prayer; prophetic imaginations; socio-economic injustice

  7. Enhanced thyroid iodine metabolism in patients with triiodothyronine-predominant Graves' disease

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    Takamatsu, J.; Hosoya, T.; Naito, N.

    1988-01-01

    Some patients with hyperthyroid Graves' disease have increased serum T3 and normal or even low serum T4 levels during treatment with antithyroid drugs. These patients with elevated serum T3 to T4 ratios rarely have a remission of their hyperthyroidism. The aim of this study was to investigate thyroid iodine metabolism in such patients, whom we termed T3-predominant Graves' disease. Mean thyroid radioactive iodine uptake was 51.0 +/- 18.1% ( +/- SD) at 3 h, and it decreased to 38.9 +/- 20.1% at 24 h in 31 patients with T3-predominant Graves' disease during treatment. It was 20.0 +/- 11.4% at 3 h and increased to 31.9 +/- 16.0% at 24 h in 17 other patients with hyperthyroid Graves' disease who had normal serum T3 and T4 levels and a normal serum T3 to T4 ratio during treatment (control Graves' disease). The activity of serum TSH receptor antibodies was significantly higher in the patients with T3-predominant Graves' disease than in control Graves' disease patients. From in vitro studies of thyroid tissue obtained at surgery, both thyroglobulin content and iodine content in thyroglobulin were significantly lower in patients with T3-predominant Graves' disease than in the control Graves' disease patients. Thyroid peroxidase (TPO) activity determined by a guaiacol assay was 0.411 +/- 0.212 g.u./mg protein in the T3-predominant Graves' disease patients, significantly higher than that in the control Graves' disease patients. Serum TPO autoantibody levels determined by immunoprecipitation also were greater in T3-predominant Graves' disease patients than in control Graves' disease patients. Binding of this antibody to TPO slightly inhibited the enzyme activity of TPO, but this effect of the antibody was similar in the two groups of patients

  8. Healthy human T-Cell Responses to Aspergillus fumigatus antigens.

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    Neelkamal Chaudhary

    2010-02-01

    Full Text Available Aspergillus fumigatus is associated with both invasive and allergic pulmonary diseases, in different hosts. The organism is inhaled as a spore, which, if not cleared from the airway, germinates into hyphal morphotypes that are responsible for tissue invasion and resultant inflammation. Hyphae secrete multiple products that function as antigens, evoking both a protective (T(H1-T(H17 and destructive allergic (T(H2 immunity. How Aspergillus allergens (Asp f proteins participate in the development of allergic sensitization is unknown.To determine whether Asp f proteins are strictly associated with T(H2 responses, or represent soluble hyphal products recognized by healthy hosts, human T cell responses to crude and recombinant products were characterized by ELISPOT. While responses (number of spots producing IFN-gamma, IL-4 or IL-17 to crude hyphal antigen preparations were weak, responses to recombinant Asp f proteins were higher. Recombinant allergens stimulated cells to produce IFN-gamma more so than IL-4 or IL-17. Volunteers exhibited a diverse CD4+ and CD8+ T cell antigen recognition profile, with prominent CD4 T(H1-responses to Asp f3 (a putative peroxismal membrane protein, Asp f9/16 (cell wall glucanase, Asp f11 (cyclophilin type peptidyl-prolyl isomerase and Asp f22 (enolase. Strong IFN-gamma responses were reproduced in most subjects tested over 6 month intervals.Products secreted after conidial germination into hyphae are differentially recognized by protective T cells in healthy, non-atopic individuals. Defining the specificity of the human T cell repertoire, and identifying factors that govern early responses may allow for development of novel diagnostics and therapeutics for both invasive and allergic Aspergillus diseases.

  9. Healthy human T-Cell Responses to Aspergillus fumigatus antigens.

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    Chaudhary, Neelkamal; Staab, Janet F; Marr, Kieren A

    2010-02-17

    Aspergillus fumigatus is associated with both invasive and allergic pulmonary diseases, in different hosts. The organism is inhaled as a spore, which, if not cleared from the airway, germinates into hyphal morphotypes that are responsible for tissue invasion and resultant inflammation. Hyphae secrete multiple products that function as antigens, evoking both a protective (T(H)1-T(H)17) and destructive allergic (T(H)2) immunity. How Aspergillus allergens (Asp f proteins) participate in the development of allergic sensitization is unknown. To determine whether Asp f proteins are strictly associated with T(H)2 responses, or represent soluble hyphal products recognized by healthy hosts, human T cell responses to crude and recombinant products were characterized by ELISPOT. While responses (number of spots producing IFN-gamma, IL-4 or IL-17) to crude hyphal antigen preparations were weak, responses to recombinant Asp f proteins were higher. Recombinant allergens stimulated cells to produce IFN-gamma more so than IL-4 or IL-17. Volunteers exhibited a diverse CD4+ and CD8+ T cell antigen recognition profile, with prominent CD4 T(H)1-responses to Asp f3 (a putative peroxismal membrane protein), Asp f9/16 (cell wall glucanase), Asp f11 (cyclophilin type peptidyl-prolyl isomerase) and Asp f22 (enolase). Strong IFN-gamma responses were reproduced in most subjects tested over 6 month intervals. Products secreted after conidial germination into hyphae are differentially recognized by protective T cells in healthy, non-atopic individuals. Defining the specificity of the human T cell repertoire, and identifying factors that govern early responses may allow for development of novel diagnostics and therapeutics for both invasive and allergic Aspergillus diseases.

  10. The Relationship Between Critical Thinking Skills with Mental Health and Academic Achievement of Qom University of Medical Sciences Students

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    Zahra Moslemi

    2017-06-01

    Full Text Available Background and Objective: Critical thinking is one of the goals in higher education and a key element in students' mental health. This study aims to investigate the relationship between critical thinking skills with mental health and academic achievement of Qom University of Medical Sciences students. Materials and Methods: In this descriptive­-correlation study in 1394,a sample of 303students at Qom University of Medical Sciences were selected through stratified random sampling method with a view to gender.The data were collected through two standard questionnaires on critical thinking skills CCTST form(B and mental health questionnaire of GHQ-28.Then the data were analyzed simultaneously using descriptive statistics methods, Pearson correlation and independent t-test, and multiple regression analysis. Results: Students’ mean score of critical thinking skills was (9.16 ± 3.15 which was interpreted as under average. The results of Pearson correlation test showed that there was no significant relationship between critical thinking skills and mental health (P=0.702, r=0.039 and academic achievement (P=0.284, r=0.081.There was also no significant relationship between mental health and academic achievement (P=0.141, r=-0.150. According to independent t-test results, there was no significant difference between male and female students’ average scores in critical thinking skills and mental health. But there was a significant difference between male and female students in academic achievement. Finally multiple regression analysis revealed that mental health and academic achievement did not predict any critical thinking skills. Conclusion: Considering that strengthening critical thinking in students and enhancing learning methods can improve learning skills and factors affecting their learning Therefore, by modifying and providing appropriate educational practices, critical thinking of students can be enhanced.

  11. Clinical patterns associated with the concurrent detection of anti-HBs and HBV DNA.

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    Anastasiou, Olympia E; Widera, Marek; Korth, Johannes; Kefalakes, Helenie; Katsounas, Antonios; Hilgard, Gudrun; Gerken, Guido; Canbay, Ali; Ciesek, Sandra; Verheyen, Jens

    2018-02-01

    Simultaneous detection of anti-HBs and HBV DNA is a rare serological combination and has been described in acute and chronic HBV infection. To scrutinize viral and clinical patterns associated with concurrent detection of anti-HBs and HBV DNA. Simultaneous detection of anti-HBs and HBV DNA was observed in 64/1444 (4.4%) patients treated for HBV infection at the University Hospital of Essen from 2006 to 2016 (8 with acute, 20 with reactivated, and 36 chronic HBV infection). Clinical data and laboratory parameters were analyzed. Regions of the small hepatitis B surface antigen (SHB) and the reverse transcriptase (RT) were sequenced using next generation sequencing (NGS). Among the 64 patients with detectable HBV DNA and anti-HBs, 17 were HBsAg negative (HBsAg[-]), and two had acute liver failure. Patients with acute HBV infection had fewer genotype specific amino acid substitutions in the SHB region than patients with reactivated HBV infection (4 [4.5] vs 9 [16.25], P = 0.043). However, we could observe a significantly higher number of mutations in the a-determinant region when comparing chronically infected patients to patients with acute infection (0 [1] vs 1 [1], P = 0.044). The ratio of nonsynonymous to synonymous mutations (Ka/Ks) was on average >1 for the SHB region and 1) in the SHB region indicates that anti-HBs might have exerted selection pressure on the HBsAg. In three cases the diagnosis of acute HBV infection would have been at least delayed by only focusing on HBsAg testing. © 2017 Wiley Periodicals, Inc.

  12. Effects of ketoconazole and valproic acid on the pharmacokinetics of the next generation NNRTI, lersivirine (UK-453,061), in healthy adult subjects

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    Langdon, Grant; Davis, John; Layton, Gary; Chong, Chew-Lan; Weissgerber, Georges; Vourvahis, Manoli

    2012-01-01

    AIMS To investigate the effect of inhibitors of cytochrome P450 (CYP) 3A4 and glucuronidation (UGT2B7) on the pharmacokinetics of lersivirine (UK-453,061), a next generation non-nucleoside reverse transcriptase inhibitor with a unique resistance profile, and to investigate the safety and tolerability of co-administration of lersivirine with these inhibitors. METHODS Two open-label, randomized, placebo-controlled, crossover studies were conducted in healthy subjects. Study 1 investigated the effect of ketoconazole (400 mg once daily) on the pharmacokinetics of lersivirine (250 mg once daily). Subjects received ketoconazole 400 mg once daily or placebo on days 1–2 and received lersivirine 250 mg once daily and ketoconazole 400 mg once daily or placebo on days 3–9. Study 2 investigated the effect of valproic acid (VPA, sodium valproate, 1000 mg once daily) on the PK of lersivirine (500 mg once daily). On days 1–7, subjects received lersivirine 500 mg once daily plus either VPA 1000 mg or placebo. RESULTS Compared with lersivirine alone, co-administration with ketoconazole increased the lersivirine mean area under the curve (AUC(0,24 h)) and maximum plasma concentration (Cmax) by 82% (90% CI 74%, 91%) and 61% (90% CI 41%, 83%), respectively. VPA increased the mean lersivirine AUC(0,24 h) by 25% (90% CI 16%, 35%), with little effect on Cmax (2.5%, 90% CI −9%, 16%). There were no serious adverse events and no treatment-related discontinuations from either study. CONCLUSIONS Inhibition of CYP3A4 and UGT2B7 by ketoconazole increased lersivirine exposure. Inhibition of UGT2B7-mediated glucuronidation by VPA had a modest effect on lersivirine exposure. Co-administration of lersivirine with either ketoconazole or VPA appeared to be well tolerated. PMID:22040521

  13. On alcanthosis provoked by Tween 60, coal tar destillate, and X-radiation

    International Nuclear Information System (INIS)

    Weiland, E.

    1980-01-01

    Three animal groups, each consisting of 30 guinea-pigs, were investigated. In Group 1 we used water as base and Tween 60 as agent. Group 2 was treated with Elfon NS 242 as base and Fluxoil ST as agent. Unlike the animals treated with chemical reagents, Group 3 was exposed once to X-radiation (2000 R). The animals were examined after 9, 16, 23, 30 and 37 days. In these examinations not only the thymidine-labelling index (TLI) was calculated by autoradiography, but also the thickness of the epidermis and the cell number were determined by planimetry. After treatment with Tween 60 the result was a slightly increased TLI with respect to the base and a notable increase over the whole period of application with regards to the agent. The thickness of the epidermis behaved in analogue manner. With reference to the TLI the coal tar destillate presented a maximum on the 9th day which - with delay - could be observed on the 23rd day also in the thickness of the epidermis. The base Elfan NS 242 caused a constant increase with reference to the TLI and to the thickness of the epidermis. The skin which had been exposed to X-radiation showed that, compared to the TLI, acanthosis subsides with delay. On the 16th day an evidently pronounced maximum of the TLI and of the thickness of epidermis was to be seen. These results led us to the conclusions that the retention acanthosis, caused by coal tar and X-radiation, is probably accompanied by a prolongation of the time of DNS-synthesis and with reference to time lags behind the delay of the DNS-synthesis time. In spite of continuous applications in both cases, the retentional acanthosis provoked by coal tar presents a course which with reference to time is completely different from the proliferation acanthosis induced by detergents. (orig./MG) [de

  14. Sensorimotor difficulties are associated with the severity of autism spectrum conditions.

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    Penelope Hannant

    2016-08-01

    Full Text Available Present diagnostic criteria for autism spectrum conditions (ASC include social communication and interaction difficulties, repetitive behaviour and movement, and atypical sensory responsivity. Few studies have explored the influence of motor coordination and sensory responsivity on severity of ASC symptoms. In the current study, we explore whether sensory responsivity and motor coordination differences can account for the severity of autistic behaviours in children with ASC. 36 children took part: 18 (13 male, 5 female with ASC (ages 7-16: mean age 9.93 years and 18 (7 male, 11 female typically developing (TD children (ages 6-12; mean age 9.16 years. Both groups completed a battery of assessments that included motor coordination, sensory responsivity, receptive language, non-verbal reasoning and social communication measures Children with ASC also completed the Autism Diagnostic Observation Schedule and Autism Diagnostic Interview – Revised.. Results showed that children with ASC scored significantly lower on receptive language, coordination and sensory responsivity and a sensorimotor subscale, Modulation of Activity (MoA compared to the TD group. In the ASC group, MoA significantly predicted ASC severity across all ASC measures; receptive language and sensory responsivity significantly predicted parental reported autism measures; and coordination significantly predicted examiner observed reported scores. Additionally, specific associations were found between the somatosensory perceptive modalities and ASC severity. The results show that sensorimotor skills are associated with severity of ASC symptoms; furthering the need to research sensorimotor integration in ASC and also implying that diagnosis of ASC should also include the assessment of both coordination deficit and atypical sensory responsivity.

  15. Hospitalised ocular injuries in Osogbo, Nigeria

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    Olubayo Umar Kolawole

    2015-11-01

    Full Text Available AIM: To describe the epidemiology and outcome of ocular injuries requiring hospital admission in Ladoke Akintola University of Technology Teaching Hospital(LTH, Osogbo, Nigeria.METHODS: Retrospective chart review of all patients hospitalized for ocular injuries at LTH, Osogbo between April 2002 and March 2014 was undertaken. Information extracted from patients records were entered into a pre-designed form. Data were analyzed with Statistical Package for Social Sciences(SPSSversion 20. Logistic regression analysis was used to assess effects of different variables on the visual outcome of ocular injuries after treatment among the subjects. PRESULTS: One hundred and twenty-seven patients were hospitalized at LTH within the study period. The median age was 22.0y(range: 0.5-70.0and male: female ratio 2.6:1. Majority of the injuries(35.2%occurred within the home setting. Of the 127 patients, 74(58.3%had open globe Injuries(OGI, 34(26.8%had closed globe injuries(CGI, 7(5.5%had adnexal injuries, 6(4.7%had ruptured globes, 4(3.1%had chemical injuries, 1(0.8%patient each had retained intraocular foreign body and thermal eye injury. Two-thirds of patients managed for ocular injuries in this series had poor visual outcome. There were statistically significant associations between poor initial visual acuity(OR=13.24and OGI with poor visual outcome(OR=9.16.CONCLUSION: There is an urgent need for health education and, to put in place preventive strategies for ocular injuries. Developing countries need to build up capacity to offer complex anterior and posterior segment surgeries for those with severely injured eyes so as to improve the visual outcomes.

  16. Calcineurin Inhibitors in the Treatment of Primary Focal Segmental Glomerulosclerosis

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    Louis-Philippe Laurin

    2017-02-01

    Full Text Available Purpose of review: Primary focal segmental glomerulosclerosis (FSGS is the most common cause of nephrotic syndrome in adults. Glucocorticoids have been evaluated in the treatment of primary FSGS in numerous retrospective studies. Evidence suggesting a role for including calcineurin inhibitors (CNIs in early therapy remains limited. The aim of this study was to systematically review the literature examining the efficacy of CNIs in the treatment of primary FSGS both as first-line therapy and as an adjunctive agent in steroid-resistant patients, with respect to remission in proteinuria and renal survival. Sources of information: PubMed and EMBASE were searched from inception to August 2014 for prospective controlled trials, and case-control and cohort studies. Findings: After systematically applying our inclusion criteria, a total of 152 titles and abstracts were identified. Six randomized controlled trials and 2 cohort studies were reviewed. Three randomized controlled trials compared CNIs with placebo or supportive therapy. The pooled relative “risk” of proteinuria remission associated with cyclosporine was 7.0 (95% confidence interval, 2.9-16.8 compared with placebo/supportive therapy. There was very low heterogeneity among these studies with an I -squared of 0%. Three studies compared CNIs with another immunosuppressive agent. All prospective trials were conducted in patients with primary FSGS deemed steroid-resistant. Limitations: The relatively small number of included studies and their heterogeneity with respect to treatment protocols, and possible publication bias, limit conclusions drawn from this systematic review. Implications: The efficacy of CNIs has been evaluated in steroid-resistant primary FSGS patients. There is no evidence supporting their role as first-line therapy. Further studies are needed to determine this role.

  17. Evaluating the effect of rectal distension and rectal movement on prostate gland position using cine MRI

    International Nuclear Information System (INIS)

    Padhani, Anwar R.; Khoo, Vincent S.; Suckling, John; Husband, Janet E.; Leach, Martin O.; Dearnaley, David P.

    1999-01-01

    Purpose: To evaluate the dynamic interrelationship between rectal distension and rectal movements, and to determine the effect of rectal movement on the position of the prostatic gland using cine magnetic resonance imaging (MRI). Methods and Materials: Fifty-five patients with biopsy-proven or suspected prostate cancer were examined in the axial plane using repeated spoiled gradient-echo sequences every 10 seconds for 7 minutes. Twenty-four patients received bowel relaxants before imaging. Images were analyzed for the degree of rectal distension, for the incidence, magnitude, and number of rectal and prostate movements. Results: Rectal movements were seen in 28 (51%) patients overall, in 10 (42%) of those receiving bowel relaxants and in 18 (58%) not receiving bowel relaxants. The incidence of rectal movements correlated with the degree of rectal distension (p = 0.0005), but the magnitude of rectal movements did not correlate with the degree of rectal distension. Eighty-six rectal movements resulting in 33 anterior-posterior (AP) prostate movements were seen. The magnitude of rectal movements correlated well with degree of prostate movements (p < 0.001). Prostate movements in the AP direction were seen in 16 (29%) patients, and in 9 (16%) patients the movement was greater than 5 mm. The median prostate AP displacement was anterior by 4.2 (-5 to +14 mm). Conclusions: Cine MRI is able to demonstrate near real time rectal and associated prostate movements. Rectal movements are related to rectal distension and result in significant displacements of the prostate gland over a time period similar to that used for daily fractionated radiotherapy treatments. Delivery of radiotherapy needs to take into account these organ movements

  18. Self-concept evaluation and migraine without aura in childhood.

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    Esposito, Maria; Gallai, Beatrice; Parisi, Lucia; Castaldo, Laura; Marotta, Rosa; Lavano, Serena Marianna; Mazzotta, Giovanni; Roccella, Michele; Carotenuto, Marco

    2013-01-01

    Self-esteem is related to the broadly understood concept of self-schemas and is a crucial mechanism for a correct psychological development in children and adolescents. The impact of the many psychological difficulties linked to the migraine without aura (MoA) and recurrent headache attacks, such as anger and separation anxiety, on self-esteem has not yet been well investigated. The aims of the present study were to assess self-esteem levels in an objective way and to verify their possible relationship and correlation with the frequency and intensity of migraine attacks, in a population of children and adolescents affected by MoA. The study population was comprised of 185 children (88 males [M],97 females [F]) aged between 6 and 12 years (mean 9.04 ± 2.41 years) referred consecutively for MoA to the Center for Childhood Headache, Clinic of Child and Adolescent Neuropsychiatry, Second University of Naples and of 203 healthy controls (95 M, 108 F) with mean age 9.16 ± 2.37 years, recruited from schools in Campania. The monthly headache frequency and the mean headache duration were assessed from daily headache diaries kept by all the children, and MoA intensity was assessed on a VAS (visual analog scale). To further evaluate their level of self-concept, all subjects filled out the Multidimensional Self-Concept Scale (MSCS). The two study groups were comparable for age (P = 0.621), sex (P = 0.960), and z-score BMI (P = 0.102). The MoA group showed a significant reduction in the MSCS total score (P self-esteem levels, with an objective tool, in children affected by MoA compared with controls, suggesting the need for evaluation of self-esteem for better psychological pediatric management of children with migraine.

  19. Expression of BAGE, GAGE, and MAGE genes in human gastric carcinoma.

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    Li, J; Yang, Y; Fujie, T; Baba, K; Ueo, H; Mori, M; Akiyoshi, T

    1996-09-01

    The MAGE, BAGE, and GAGE genes code for distinct antigens that are recognized by autologous cytolytic T lymphocytes. We investigated the expression of these genes in both cell lines and surgical samples of gastric carcinoma, using reverse transcription-PCR. Furthermore, the induction of these genes by 5-aza-2'-deoxycytidine (DAC), a demethylating agent, was also examined in several cell lines. Of 11 cell lines, BAGE, GAGE1-6, GAGE1-2, MAGE-1, and MAGE-3 were detected in 7 (64%), 4 (36%), 3 (27%), 8 (73%), and 8 (73%) cell lines, respectively. After the in vitro treatment of the negative cell lines with DAC, the expression of these genes became positive in 46 to 91% of these cell lines. No expression of these genes was seen in any of the 57 samples of normal gastric tissue. In contrast, the tumor tissue samples expressed BAGE, GAGE1-6, GAGE1-2, MAGE-1, and MAGE-3 in 13 (23%), 9 (16%), 6 (11%), 25 (44%), and 23 (40%) tissue samples, respectively. Thus, at least one of these genes was expressed in 35 (61%) of 57 carcinomas. An analysis of the relationship between clinicopathological factors and the expression of these genes revealed that either BAGE or one of these genes was more frequently expressed in histologically intestinal-type than in diffuse-type carcinomas. Our results suggest that, because of the higher expression of these genes and the possible induction of these genes by DAC, patients with gastric carcinoma may, therefore, be potential candidates for tumor-specific immunotherapy directed against these antigens.

  20. THE EFFECT OF RECOMBINANT HUMAN LEUKEMIA INHIBITORY FACTOR (rhLIF ON IN VITRO DEVELOPMENT OF MOUSE 2-CELL EMBRYOS AND THEIR ISOLATED BLASTOMERES

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    MOHAMMAD AKBARI

    2004-09-01

    Full Text Available In this study effect of recombinant human leukemia inhibitory factor on invitro development of 2 cells embryos and isolated blastomeres derived from mouse 2 cell embryos were investigated. Female ICR mice that were between 8 to 10 weeks old received intraperitoneal injection of 7.5 IU of PMSG for super ovulation followed by intraperitoneal administration of 7.5 IU of HCG 48 hours later. The mice were then mated to mature ICR male mice and were checked for vaginal plugs after 13-14 hours. Mice were killed 46-48 hours after HCG injection by cervical dislocation, their oviducts were removed and flushing 2 cell embryos were collected. The zona pellucida of 2 cell embryos were removed by Acid Tyrod solution and blastomeres separated with oocyte preparation pipette and then all embryos and blastomeres were cultured in Potassium Simplex Optimized Medium (KSOM +Aminoacid (AA different amounts of rhLIF (500IU/ml, 1000IU/ml and 1500IU/ml. Some embryos and individual blastomere also were cultured without rhLIF as control group. All samples were cultured in an incubator at 370C with 0.05 CO2 for 120 hours. The rate of embryo and individual blastomeres which reached to 2 cell, 4 cell, 8 cell and 9-16 cell were the same in all groups. However in further developmental stages, morula and blastocyst between experimental and control groups were significantly different. Therefore it may be concluded that: cultivation of isolated blastomers up to the blastocyst stage with rhLIF has stimulatory effect on the preimplantation stage (morula and blastocyst but it has no stimulatory and inhibitory effects when was added to culture media at the early cleavage stage.