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Sample records for nir ingaas imager

  1. Characterization of NIR InGaAs imager arrays for the JDEM SNAPmission concept

    Energy Technology Data Exchange (ETDEWEB)

    Seshadri, S.; Cole, M.D.; Hancock, B.; Ringold, P.; Wrigley, C.; Bonati, M.; Brown, M.G.; Schubnell, M.; Rahmer, G.; Guzman, D.; Figer,D.; Tarle, G.; Smith, R.M.; Bebek, C.

    2006-05-23

    We present the results of a study of the performance of InGaAs detectors conducted for the SuperNova Acceleration Probe (SNAP) dark energy mission concept. Low temperature data from a nominal 1.7um cut-off wavelength 1kx1k InGaAs photodiode array, hybridized to a Rockwell H1RG multiplexer suggest that InGaAs detector performance is comparable to those of existing 1.7um cut-off HgCdTe arrays. Advances in 1.7um HgCdTe dark current and noise initiated by the SNAP detector research and development program makes it the baseline detector technology for SNAP. However, the results presented herein suggest that existing InGaAs technology is a suitable alternative for other future astronomy applications.

  2. Generating passive NIR images from active LIDAR

    Science.gov (United States)

    Hagstrom, Shea; Broadwater, Joshua

    2016-05-01

    Many modern LIDAR platforms contain an integrated RGB camera for capturing contextual imagery. However, these RGB cameras do not collect a near-infrared (NIR) color channel, omitting information useful for many analytical purposes. This raises the question of whether LIDAR data, collected in the NIR, can be used as a substitute for an actual NIR image in this situation. Generating a LIDAR-based NIR image is potentially useful in situations where another source of NIR, such as satellite imagery, is not available. LIDAR is an active sensing system that operates very differently from a passive system, and thus requires additional processing and calibration to approximate the output of a passive instrument. We examine methods of approximating passive NIR images from LIDAR for real-world datasets, and assess differences with true NIR images.

  3. Near Infrared (nir) Imaging for Nde

    Science.gov (United States)

    Diamond, G. G.; Pallav, P.; Hutchins, D. A.

    2008-02-01

    A novel application of near infrared (NIR) signals is presented, which can be used to provide images of many different materials and objects. It is effectively a very low cost non-ionising alternative to many applications currently being investigated using electromagnetic waves at other frequencies, such as THz and X-ray imaging. This alternative technique can be realised by very simple and inexpensive electronics and is inherently far more portable and easy to use. Transmission imaging results from this technique are presented from examples industrial quality control, food inspection and various security applications, and the results compared to existing techniques. In addition, this technique can be used in through-transmission mode on biological and medical samples, and images are presented that differentiate between not only flesh and bone, but also various types of soft tissue.

  4. Food quality assessment by NIR hyperspectral imaging

    Science.gov (United States)

    Whitworth, Martin B.; Millar, Samuel J.; Chau, Astor

    2010-04-01

    Near infrared reflectance (NIR) spectroscopy is well established in the food industry for rapid compositional analysis of bulk samples. NIR hyperspectral imaging provides new opportunities to measure the spatial distribution of components such as moisture and fat, and to identify and measure specific regions of composite samples. An NIR hyperspectral imaging system has been constructed for food research applications, incorporating a SWIR camera with a cooled 14 bit HgCdTe detector and N25E spectrograph (Specim Ltd, Finland). Samples are scanned in a pushbroom mode using a motorised stage. The system has a spectral resolution of 256 pixels covering a range of 970-2500 nm and a spatial resolution of 320 pixels covering a swathe adjustable from 8 to 300 mm. Images are acquired at a rate of up to 100 lines s-1, enabling samples to be scanned within a few seconds. Data are captured using SpectralCube software (Specim) and analysed using ENVI and IDL (ITT Visual Information Solutions). Several food applications are presented. The strength of individual absorbance bands enables the distribution of particular components to be assessed. Examples are shown for detection of added gluten in wheat flour and to study the effect of processing conditions on fat distribution in chips/French fries. More detailed quantitative calibrations have been developed to study evolution of the moisture distribution in baguettes during storage at different humidities, to assess freshness of fish using measurements of whole cod and fillets, and for prediction of beef quality by identification and separate measurement of lean and fat regions.

  5. NIR autofluorescence and OCT imaging of biotissues

    Science.gov (United States)

    Chorvat, Dusan, Jr.; Smolka, Jozef; Mateasik, Anton; Hrin, Lubos

    2003-10-01

    Optical coherence tomography (OCT) is one of the most promising recently developed methods for non-invasive in vivo characterization of biological highly scattering tissues. However, one of the drawbacks of the pure OCT imaging is that it is not sensitive to changes in metabolism. This may impact derived information and consecutive diagnostics, because pathological changes of tissue structure are accompanied with changes in metabolic activity or functional state in these areas even if there is not yet strongly evident structural change. Therefore, it is desirable to combine early detection of tissue malformations by OCT with other techniques, capable to detect and evaluate their functional state. One of suitable candidates for such non-invasive optical functional imaging is detection of laser induced autofluorescence, which could provide information about rate of biological and chemical processes in living cells. As an example, the cells in proliferative state (with increased metabolic activity or during mitosis) show more intensive NIR fluorescence than the cells that are not proliferative, because of increased concentration of free porphyrins. In presented study we used OCT and laser induced NIR autofluorescence imaging for detection and evaluation of changes in areas of naevus and injuries in group of volunteers. The fusion of information on structural and functional state of biotissues provided by the two mentioned complementary methods may enhance the diagnostics power of their prospective clinical use. Firstly the fluorescence of area of naevus and injuries, excited by 630 nm was taken by CCD camera and then was naevus scanned by OCT. The findings of both methods were compared and correlated. In the case of naevus the obtained results were reviewed with histological treatment of the same area.

  6. A review of NIR dyes in cancer targeting and imaging.

    Science.gov (United States)

    Luo, Shenglin; Zhang, Erlong; Su, Yongping; Cheng, Tianmin; Shi, Chunmeng

    2011-10-01

    The development of multifunctional agents for simultaneous tumor targeting and near infrared (NIR) fluorescence imaging is expected to have significant impact on future personalized oncology owing to the very low tissue autofluorescence and high tissue penetration depth in the NIR spectrum window. Cancer NIR molecular imaging relies greatly on the development of stable, highly specific and sensitive molecular probes. Organic dyes have shown promising clinical implications as non-targeting agents for optical imaging in which indocyanine green has long been implemented in clinical use. Recently, significant progress has been made on the development of unique NIR dyes with tumor targeting properties. Current ongoing design strategies have overcome some of the limitations of conventional NIR organic dyes, such as poor hydrophilicity and photostability, low quantum yield, insufficient stability in biological system, low detection sensitivity, etc. This potential is further realized with the use of these NIR dyes or NIR dye-encapsulated nanoparticles by conjugation with tumor specific ligands (such as small molecules, peptides, proteins and antibodies) for tumor targeted imaging. Very recently, natively multifunctional NIR dyes that can preferentially accumulate in tumor cells without the need of chemical conjugation to tumor targeting ligands have been developed and these dyes have shown unique optical and pharmaceutical properties for biomedical imaging with superior signal-to-background contrast index. The main focus of this article is to provide a concise overview of newly developed NIR dyes and their potential applications in cancer targeting and imaging. The development of future multifunctional agents by combining targeting, imaging and even therapeutic routes will also be discussed. We believe these newly developed multifunctional NIR dyes will broaden current concept of tumor targeted imaging and hold promise to make an important contribution to the diagnosis

  7. High dynamic solutions for short-wavelength infrared imaging based on InGaAs

    Science.gov (United States)

    Reverchon, Jean-Luc; Decobert, Jean; Djedidi, Anis; Gentner, Jean-Louis; Huet, Odile; Lagay, Nadine; Rouvié, Anne; Robo, Jean-Alexandre; Truffer, Jean-Patrick; Costard, Eric; Ni, Yang; Arion, Bogdan; Zhu, Yiming; Potet, Pierre

    2011-06-01

    Short-wavelength infrared image sensors based on p-i-n photodiode arrays present a tremendous interest in applications such as passive and active imagery for laser detection/warning, hot spot or detection for lasers sensors, enhanced vision systems or low light level sensors. The capability to work at room temperature with dark current equivalent to silicon-based devices is another motivation for the fast development of this technology. This paper presents several modules and camera based on InGaAs photodiode arrays from the III-VLab. First, we describe the electro-optics performance in terms of dark signal, sensitivity, and particularly the visible extension capability. We also present a nucless logarithmic sensor based on a 1/2 video graphics array (VGA) format at a pitch of 25 μm initially designed for visible CMOS camera chip. We will also present the next generation of focal plane arrays based on a VGA format of 640×512 pixels with a pitch of 15 μm. This array will be associated to a CTIA readout circuit and also to an innovative CMOS logarithmic wide dynamic range ROIC, developed by New Imaging Technologies. This VGA logarithmic device developed for automotive safety will involve visible extension capability in a European project named 2Wide_sense.

  8. New confocal microscopy hyperspectral imager for NIR-emitting bioprobes: high spectral resolution for a wide spectral range (Conference Presentation)

    Science.gov (United States)

    Marcet, Stéphane; Benayas, Antonio; Quintanilla, Marta; Mangiarini, Francesca; Verhaegen, Marc; Vetrone, Fiorenzo; Blais-Ouellette, Sébastien

    2016-03-01

    Functional nanoscale materials are being extensively investigated for applications in biology and medicine and are ready to make significant contributions in the realization of exciting advancements in diverse areas of diagnostics and therapeutics. Aiming for more accurate, efficient, non-invasive and fast diagnostic tools, the use of near-infrared (NIR) light in the range of the 1st and 2nd biological window (NIR-I: 0.70-0.95 µm; NIR-II: 1.00-1.35 µm) provides deeper penetration depth into biological tissue, better image contrast, reduced phototoxicity and photobleaching. Consequently, NIR-based bioimaging became a quickly emerging field and manifold new NIR-emitting bioprobes have been reported. Since commercially available microscopes are not optimized for this kind of NPs, a new microscopy hyperspectral confocal imager has been developed to cover a broad spectral range (400 to 1700 nm) with high spectral resolution. The smallest spectral variation can be easily monitored thanks to the high spectral resolution (as low as 0.2 nm). This is possible thanks to a combination of an EMCCD and an InGaAs camera with a high resolution spectrometer. An extended number of NPs can be excited with a Ti:Sapphire laser, which provides tunable illumination within 690-1040 nm. Cells and tissues can be mapped in less than 100 ms, allowing in-vivo imaging. As a proof of concept, here we present the preliminary results of the spatial distribution of the fluorescence signal intensity from lanthanide doped nanoparticles incorporated into a system of biological interest. The temperature sub-mm gradient - analyzing the spectral features so gathered through an all-optical route is also thoroughly discussed.

  9. A small-molecule dye for NIR-II imaging.

    Science.gov (United States)

    Antaris, Alexander L; Chen, Hao; Cheng, Kai; Sun, Yao; Hong, Guosong; Qu, Chunrong; Diao, Shuo; Deng, Zixin; Hu, Xianming; Zhang, Bo; Zhang, Xiaodong; Yaghi, Omar K; Alamparambil, Zita R; Hong, Xuechuan; Cheng, Zhen; Dai, Hongjie

    2016-02-01

    Fluorescent imaging of biological systems in the second near-infrared window (NIR-II) can probe tissue at centimetre depths and achieve micrometre-scale resolution at depths of millimetres. Unfortunately, all current NIR-II fluorophores are excreted slowly and are largely retained within the reticuloendothelial system, making clinical translation nearly impossible. Here, we report a rapidly excreted NIR-II fluorophore (∼90% excreted through the kidneys within 24 h) based on a synthetic 970-Da organic molecule (CH1055). The fluorophore outperformed indocyanine green (ICG)-a clinically approved NIR-I dye-in resolving mouse lymphatic vasculature and sentinel lymphatic mapping near a tumour. High levels of uptake of PEGylated-CH1055 dye were observed in brain tumours in mice, suggesting that the dye was detected at a depth of ∼4 mm. The CH1055 dye also allowed targeted molecular imaging of tumours in vivo when conjugated with anti-EGFR Affibody. Moreover, a superior tumour-to-background signal ratio allowed precise image-guided tumour-removal surgery.

  10. A small-molecule dye for NIR-II imaging

    Science.gov (United States)

    Antaris, Alexander L.; Chen, Hao; Cheng, Kai; Sun, Yao; Hong, Guosong; Qu, Chunrong; Diao, Shuo; Deng, Zixin; Hu, Xianming; Zhang, Bo; Zhang, Xiaodong; Yaghi, Omar K.; Alamparambil, Zita R.; Hong, Xuechuan; Cheng, Zhen; Dai, Hongjie

    2016-02-01

    Fluorescent imaging of biological systems in the second near-infrared window (NIR-II) can probe tissue at centimetre depths and achieve micrometre-scale resolution at depths of millimetres. Unfortunately, all current NIR-II fluorophores are excreted slowly and are largely retained within the reticuloendothelial system, making clinical translation nearly impossible. Here, we report a rapidly excreted NIR-II fluorophore (~90% excreted through the kidneys within 24 h) based on a synthetic 970-Da organic molecule (CH1055). The fluorophore outperformed indocyanine green (ICG)--a clinically approved NIR-I dye--in resolving mouse lymphatic vasculature and sentinel lymphatic mapping near a tumour. High levels of uptake of PEGylated-CH1055 dye were observed in brain tumours in mice, suggesting that the dye was detected at a depth of ~4 mm. The CH1055 dye also allowed targeted molecular imaging of tumours in vivo when conjugated with anti-EGFR Affibody. Moreover, a superior tumour-to-background signal ratio allowed precise image-guided tumour-removal surgery.

  11. Human brain activity with functional NIR optical imager

    Science.gov (United States)

    Luo, Qingming

    2001-08-01

    In this paper we reviewed the applications of functional near infrared optical imager in human brain activity. Optical imaging results of brain activity, including memory for new association, emotional thinking, mental arithmetic, pattern recognition ' where's Waldo?, occipital cortex in visual stimulation, and motor cortex in finger tapping, are demonstrated. It is shown that the NIR optical method opens up new fields of study of the human population, in adults under conditions of simulated or real stress that may have important effects upon functional performance. It makes practical and affordable for large populations the complex technology of measuring brain function. It is portable and low cost. In cognitive tasks subjects could report orally. The temporal resolution could be millisecond or less in theory. NIR method will have good prospects in exploring human brain secret.

  12. Classification of maize kernels using NIR hyperspectral imaging

    DEFF Research Database (Denmark)

    Williams, Paul; Kucheryavskiy, Sergey V.

    2016-01-01

    NIR hyperspectral imaging was evaluated to classify maize kernels of three hardness categories: hard, medium and soft. Two approaches, pixel-wise and object-wise, were investigated to group kernels according to hardness. The pixel-wise classification assigned a class to every pixel from individual...... and specificity of 0.95 and 0.93). Both feature extraction methods can be recommended for classification of maize kernels on production scale....

  13. RGB-NIR color image fusion: metric and psychophysical experiments

    Science.gov (United States)

    Hayes, Alex E.; Finlayson, Graham D.; Montagna, Roberto

    2015-01-01

    In this paper, we compare four methods of fusing visible RGB and near-infrared (NIR) images to produce a color output image, using a psychophysical experiment and image fusion quality metrics. The results of the psychophysical experiment show that two methods are significantly preferred to the original RGB image, and therefore RGB-NIR image fusion may be useful for photographic enhancement in those cases. The Spectral Edge method is the most preferred method, followed by the dehazing method of Schaul et al. We then investigate image fusion metrics which give results correlated with the psychophysical experiment results. We extend several existing metrics from 2 to 1 to M to N channel image fusion, as well as introducing new metrics based on output image colorfulness and contrast, and test them on our experimental data. While none of the individual metrics gives a ranking of the algorithms which exactly matches that of the psychophysical experiment, through a combination of two metrics we accurately rank the two leading fusion methods.

  14. Extended short-wavelength spectral response from InGaAs focal plane arrays

    Science.gov (United States)

    Hoelter, Theodore R.; Barton, Jeffrey B.

    2003-09-01

    InGaAs detector material used in near infrared focal plane arrays (NIR FPAs) has typically been limited in spectral response to a range from approximately 900 nm to 1700 nm. Through special processing techniques, the spectral response can be extended down through the visible spectrum and into the ultraviolet. Test results showing preliminary spectral response from 350nm to 1700 nm, responsivity, sensitivity, corrected uniformity and simultaneous imaging of NIR and visible signals will be presented along with a discussion of anticipated applications for this new sensor technology.

  15. NIR hyperspectral imaging to evaluate degradation in captopril commercial tablets.

    Science.gov (United States)

    França, Leandro de Moura; Pimentel, Maria Fernanda; Simões, Simone da Silva; Grangeiro, Severino; Prats-Montalbán, José M; Ferrer, Alberto

    2016-07-01

    Pharmaceutical quality control is important for improving the effectiveness, purity and safety of drugs, as well as for the prevention or control of drug degradation. In the present work, near infrared hyperspectral images (HSI-NIR) of tablets with different expiration dates were employed to evaluate the degradation of captopril into captopril disulfide in different layers, on the top and on the bottom surfaces of the tablets. Multivariate curve resolution (MCR) models were used to extract the concentration distribution maps from the hyperspectral images. Afterward, multivariate image techniques were applied to the concentration distribution maps (CDMs), to extract features and build models relating the main characteristics of the images to their corresponding manufacturing dates. Resolution methods followed by extracting features were able to estimate the tablet manufacture date with a prediction error of 120days. The model developed could be useful to evaluate whether a sample shows a degradation pattern consistent with the date of manufacturing or to detect abnormal behaviors in the natural degradation process of the sample. The information provided by the HIS-NIR is important for the development of the process (QbD), looking inside the formulation, revealing the behavior of the active pharmaceutical ingredient (API) during the product's shelf life. Copyright © 2016 Elsevier B.V. All rights reserved.

  16. Development of visible and NIR imaging equipment for small animals with smart pad.

    Science.gov (United States)

    Eum, Nyeon Sik; Han, Jung Hyun; Seong, Ki Woong; Lee, Jong Ha; Park, Hee Joon

    2014-01-01

    The portable visible and near-infrared (NIR) imaging equipment for a pre-clinical test with small animals was designed and developed in this paper. The developed equipment is composed of a CCD camera, a focusing lens, an objective lens, a NIR band pass filter and a NIR filter driving motor. An NIR ray is mainly used for imaging equipment because it has high light penetration depth in biological tissue. Therefore, NIR fluorescent agents are available for chemical conjugation to targeting molecules in vivo. This equipment can provide a visible image, NIR image and merged image simultaneously. A communication system was specifically established to check obtained images through a smart pad in real time. It is less dependent on space and time than the conventional system.

  17. NIR DLP hyperspectral imaging system for medical applications

    Science.gov (United States)

    Wehner, Eleanor; Thapa, Abhas; Livingston, Edward; Zuzak, Karel

    2011-03-01

    DLP® hyperspectral reflectance imaging in the visible range has been previously shown to quantify hemoglobin oxygenation in subsurface tissues, 1 mm to 2 mm deep. Extending the spectral range into the near infrared reflects biochemical information from deeper subsurface tissues. Unlike any other illumination method, the digital micro-mirror device, DMD, chip is programmable, allowing the user to actively illuminate with precisely predetermined spectra of illumination with a minimum bandpass of approximately 10 nm. It is possible to construct active spectral-based illumination that includes but is not limited to containing sharp cutoffs to act as filters or forming complex spectra, varying the intensity of light at discrete wavelengths. We have characterized and tested a pure NIR, 760 nm to 1600 nm, DLP hyperspectral reflectance imaging system. In its simplest application, the NIR system can be used to quantify the percentage of water in a subject, enabling edema visualization. It can also be used to map vein structure in a patient in real time. During gall bladder surgery, this system could be invaluable in imaging bile through fatty tissue, aiding surgeons in locating the common bile duct in real time without injecting any contrast agents.

  18. Crosstalk study of near infrared InGaAs detectors

    Science.gov (United States)

    Li, Xue; Tang, Hengjing; Li, Tao; Fan, Cui; Shao, Xiumei; Li, Jianwei; Wei, Jun; Gong, Haimei

    2016-05-01

    Crosstalk characteristics of high density FPA detectors attract widespread attention in the application of electro-optical systems. Crosstalk characteristics of near-infrared (NIR) InGaAs photodiodes and focal plane arrays (FPAs) were studied in this paper. The mesa type detector was investigated by using laser beam induced current technique (LBIC) to measure the absorption outside the designed photosensitive area, and the results show that the excess absorption enlarges the crosstalk of the adjacent pixels. The structure optimization using the effective absorption layer between the pixels can effectively reduce the crosstalk to 2.5%. The major crosstalk components of the optimization photodiode come from the electronic signal caused by carrier lateral diffusion. For the planar type detectors, test structures were used to compare the crosstalk of different structures, and the guard ring structure shows good suppression of the crosstalk. Then the back-illuminated 32x32 InGaAs photodiodes with 30μm pitch were designed, and LBIC was used to measure its lateral diffusion of the effective carriers and fill factor of photosensitive area. The results indicate that the fill factor of detectors can reach up to 98% when the diffusion region is optimized, and the minimum response exists between two neighborhood pixels. Based on these crosstalk measurement results and optimizing structure designs, the linear InGaAs photodiodes were designed and thus the InGaAs FPA assembly was fabricated. The assembly shows higher electro-optical performance and good improvement on crosstalk. The assembly was applied in infrared imaging system and modulation transfer function (MTF) of FPA assembly was calculated to be above 0.50. The clear image based on FPA assembly was obtained.

  19. Spectral imaging of chemical compounds using multivariate optically enhanced filters integrated with InGaAs VGA cameras

    Science.gov (United States)

    Priore, Ryan J.; Jacksen, Niels

    2016-05-01

    Infrared hyperspectral imagers (HSI) have been fielded for the detection of hazardous chemical and biological compounds, tag detection (friend versus foe detection) and other defense critical sensing missions over the last two decades. Low Size/Weight/Power/Cost (SWaPc) methods of identification of chemical compounds spectroscopy has been a long term goal for hand held applications. We describe a new HSI concept for low cost / high performance InGaAs SWIR camera chemical identification for military, security, industrial and commercial end user applications. Multivariate Optical Elements (MOEs) are thin-film devices that encode a broadband, spectroscopic pattern allowing a simple broadband detector to generate a highly sensitive and specific detection for a target analyte. MOEs can be matched 1:1 to a discrete analyte or class prediction. Additionally, MOE filter sets are capable of sensing an orthogonal projection of the original sparse spectroscopic space enabling a small set of MOEs to discriminate a multitude of target analytes. This paper identifies algorithms and broadband optical filter designs that have been demonstrated to identify chemical compounds using high performance InGaAs VGA detectors. It shows how some of the initial models have been reduced to simple spectral designs and tested to produce positive identification of such chemicals. We also are developing pixilated MOE compressed detection sensors for the detection of a multitude of chemical targets in challenging backgrounds/environments for both commercial and defense/security applications. This MOE based, real-time HSI sensor will exhibit superior sensitivity and specificity as compared to currently fielded HSI systems.

  20. Near-Infrared Fluorescence Enhanced (NIR-FE) Molecular Imaging of Live Cells on Gold Substrates

    CERN Document Server

    Hong, Guosong; Welsher, Kevin; Chen, Zhuo; Robinson, Joshua T; Wang, Hailiang; Zhang, Bo; Dai, Hongjie

    2011-01-01

    Low quantum yields of near infrared (NIR) fluorophores have limited their capabilities as imaging probes in a transparent, low background imaging window. Here for the first time we reported near-infrared fluorescence enhance (NIR-FE) cell imaging using nanostructured Au substrate, which was employed as a general platform for both single-walled carbon nanotubes (SWNTs) and organic fluorescent labels in the NIR region. Fluorescence intensity, as well as cell targeting specificity, was greatly improved by this novel imaging technique. With NIR-FE imaging, we were able to image SWNT-stained cells at short exposure time of 300ms, and push the detectable limit of SWNT staining of cells down to an ultralow concentration of ~50 pM. Further, different degrees of fluorescence enhancement for endocytosed, intracellular SWNTs vs. nanotubes on the cell membrane at the cell/gold interface were observed, suggesting the possibility of using this technique to track the transmembrane behavior of NIR fluorophores.

  1. [Comparative research on the NIR and MIR micro-imaging of two similar plastic materials].

    Science.gov (United States)

    Wang, Dong; Ma, Zhi-Hong; Zhao, Liu; Pan, Li-Gang; Li, Xiao-Ting; Wang, Ji-Hua

    2011-09-01

    The NIR/MIR micro-imaging can supply not only the information of spectra, but also the information of spacial distribution of the sample, which is superior to the traditional NIR/MIR spectroscopy analysis. In the present paper, polyethylene and parafilm, with similar appearances, were regarded as the research objects, of which the NIR/MIR micro-imaging was collected. Chemical imaging (CI) and compare correlation imaging were carried out for the two materials respectively to discuss the imaging methods of the two materials. The result indicated that the differentiation of the CI values of the two materials in the NIR/MIR CI for material II was 0.004 8 and 0.254 8 respectively, while those in the NIR/MIR CI for material I were 0.002 6 and 0.326 5, respectively. Clear CI was acquired, and the two materials could be differentiated. The result of the compare correlation imagings indicated that the compare correlation imagings, in which the NIR/MIR spectra of the two materials were regarded as reference spectra respectively, can differentiate the two materials remarkably with clear imagings. In the compare correlation imagings of MIR micro-imaging, the difference of the correlation coefficients between the two materials' MIR spectra and the reference spectrum was more than 0.12, which showed a better imaging result; while a tiny difference of the correlation coefficients between the two materials' NIR spectra and the reference spectrum could be employed to show a clear imaging result for NIR compare correlation imaging so as to differentiate the two materials. This thesis, to some extent, can supply the reference to not only the rapid discrimination of the safety of the packaging material for agri-food, but also the imaging methods for NIR/MIR micro-imaging to differentiate the different materials.

  2. Instrumentation and method for measuring NIR light absorbed in tissue during MR imaging in medical NIRS measurements

    Science.gov (United States)

    Myllylä, Teemu S.; Sorvoja, Hannu S. S.; Nikkinen, Juha; Tervonen, Osmo; Kiviniemi, Vesa; Myllylä, Risto A.

    2011-07-01

    Our goal is to provide a cost-effective method for examining human tissue, particularly the brain, by the simultaneous use of functional magnetic resonance imaging (fMRI) and near-infrared spectroscopy (NIRS). Due to its compatibility requirements, MRI poses a demanding challenge for NIRS measurements. This paper focuses particularly on presenting the instrumentation and a method for the non-invasive measurement of NIR light absorbed in human tissue during MR imaging. One practical method to avoid disturbances in MR imaging involves using long fibre bundles to enable conducting the measurements at some distance from the MRI scanner. This setup serves in fact a dual purpose, since also the NIRS device will be less disturbed by the MRI scanner. However, measurements based on long fibre bundles suffer from light attenuation. Furthermore, because one of our primary goals was to make the measuring method as cost-effective as possible, we used high-power light emitting diodes instead of more expensive lasers. The use of LEDs, however, limits the maximum output power which can be extracted to illuminate the tissue. To meet these requirements, we improved methods of emitting light sufficiently deep into tissue. We also show how to measure NIR light of a very small power level that scatters from the tissue in the MRI environment, which is characterized by strong electromagnetic interference. In this paper, we present the implemented instrumentation and measuring method and report on test measurements conducted during MRI scanning. These measurements were performed in MRI operating rooms housing 1.5 Tesla-strength closed MRI scanners (manufactured by GE) in the Dept. of Diagnostic Radiology at the Oulu University Hospital.

  3. Biomass estimator for NIR image with a few additional spectral band images taken from light UAS

    Science.gov (United States)

    Pölönen, Ilkka; Salo, Heikki; Saari, Heikki; Kaivosoja, Jere; Pesonen, Liisa; Honkavaara, Eija

    2012-05-01

    A novel way to produce biomass estimation will offer possibilities for precision farming. Fertilizer prediction maps can be made based on accurate biomass estimation generated by a novel biomass estimator. By using this knowledge, a variable rate amount of fertilizers can be applied during the growing season. The innovation consists of light UAS, a high spatial resolution camera, and VTT's novel spectral camera. A few properly selected spectral wavelengths with NIR images and point clouds extracted by automatic image matching have been used in the estimation. The spectral wavelengths were chosen from green, red, and NIR channels.

  4. 2D substrate imaging of a tapered laser cavity based on InGaAs quantum dots

    Energy Technology Data Exchange (ETDEWEB)

    Pagano, R; O' Callaghan, J; Mukherjee, J; Mclnerney, J G; Corbett, B [Tyndall National Institute, Lee Maltings, Prospect Row, Cork (Ireland); Reithmaier, J P [Technische Physik Institute of Nanostructure Technologies and Analytics (INA) University of Kassel (Germany); Deubert, S; Forchel, A, E-mail: roberto.pagano@tyndall.i [Technische Physik, University of Wuerzburg, 97074 Wuerzburg (Germany)

    2009-11-15

    Tapered cavities are an excellent solution to obtaining high brightness semiconductor laser sources for use in applications from frequency doubling to material processing. The high power density levels reached in such lasers can lead to nonlinear mechanisms related to the refractive index variations that de-stabilise the optical field distribution inside the laser cavity. These mechanisms are detrimental to the beam quality of the laser limiting its focussing ability. In this work we map the spatial distribution and evolution of the carrier density in tapered lasers as a function of injection current. A device with a taper length of 2.75 mm, taper angle of 6{sup 0} and ridge length of 1.25 mm is used to demonstrate the principle. The active region consists of three layers of InGaAs quantum dots emitting around 950 nm. A window for imaging the spontaneous emission profile through the transparent GaAs substrate was formed by patterning the n-contact metal layer. The imaging was performed in the continuous wave regime to include the thermal-induced refractive index perturbation. The results show a non-uniform carrier and thermal distribution inside the cavity even at low current levels.

  5. Rare-Earth-Based Nanoparticles with Simultaneously Enhanced Near-Infrared (NIR)-Visible (Vis) and NIR-NIR Dual-Conversion Luminescence for Multimodal Imaging.

    Science.gov (United States)

    Ma, Dandan; Xu, Xiang; Hu, Min; Wang, Jing; Zhang, Zhenxi; Yang, Jian; Meng, Lingjie

    2016-04-05

    Multifunctional NaGdF4 :Yb(3+),Er(3+),Nd(3+) @NaGdF4 :Nd(3+) core-shell nanoparticles (called Gd:Yb(3+),Er(3+),Nd(3+) @Gd:Nd(3+) NPs) with simultaneously enhanced near-infrared (NIR)-visible (Vis) and NIR-NIR dual-conversion (up and down) luminescence (UCL/DCL) properties were successfully synthesized. The resulting core-shell NPs simultaneously emitted enhanced UCL at 522, 540, and 660 nm and DCL at 980 and 1060 nm under the excitation of a 793 nm laser. The enhanced UCL and DCL can be explained by complex energy-transfer processes, Nd(3+) →Yb(3+) →Er(3+) and Nd(3+) →Yb(3+) , respectively. The effects of Nd(3+) concentration and shell thickness on the UCL/DCL properties were systematically investigated. The UCL and DCL properties of NPs were observed under the optimal conditions: a shell Nd(3+) content of 20 % and a shell thickness of approximately 5 nm. Moreover, the Gd:Yb(3+) ,Er(3+) ,Nd(3+) @Gd:20 % Nd(3+) NPs exhibited remarkable magnetic resonance imaging (MRI) properties similar to that of a clinical agent, Omniscan. Thus, the core-shell NPs with excellent UCL/DCL/magnetic resonance imaging (MRI) properties have great potential for both in vitro and in vivo multimodal bioimaging.

  6. Application of a newly developed portable NIR imaging device to monitor the dissolution process of tablets.

    Science.gov (United States)

    Ishikawa, Daitaro; Murayama, Kodai; Awa, Kimie; Genkawa, Takuma; Komiyama, Makoto; Kazarian, Sergei G; Ozaki, Yukihiro

    2013-11-01

    We have recently developed a novel portable NIR imaging device (D-NIRs), which has a high speed and high wavelength resolution. This NIR imaging approach has been developed by utilizing D-NIRs for studying the dissolution of a model tablet containing 20 % ascorbic acid (AsA) as an active pharmaceutical ingredient and 80 % hydroxypropyl methylcellulose, where the tablet is sealed by a special cell. Diffuse reflectance NIR spectra in the 1,000 to 1,600 nm region were measured during the dissolution of the tablet. A unique band at around 1,361 nm of AsA was identified by the second derivative spectra of tablet and used for AsA distribution NIR imaging. Two-dimensional change of AsA concentration of the tablet due to water penetration is clearly shown by using the band-based image at 1,361 nm in NIR spectra obtained with high speed. Moreover, it is significantly enhanced by using the intensity ratio of two bands at 1,361 and 1,354 nm corresponding to AsA and water absorption, respectively, showing the dissolution process. The imaging results suggest that the amount of AsA in the imaged area decreases with increasing water penetration. The proposed NIR imaging approach using the intensity of a specific band or the ratio of two bands combined with the developed portable NIR imaging instrument, is a potentially useful practical way to evaluate the tablet at every moment during dissolution and to monitor the concentration distribution of each drug component in the tablet.

  7. Maize kernel hardness classification by near infrared (NIR) hyperspectral imaging and multivariate data analysis.

    Science.gov (United States)

    Williams, Paul; Geladi, Paul; Fox, Glen; Manley, Marena

    2009-10-27

    The use of near infrared (NIR) hyperspectral imaging and hyperspectral image analysis for distinguishing between hard, intermediate and soft maize kernels from inbred lines was evaluated. NIR hyperspectral images of two sets (12 and 24 kernels) of whole maize kernels were acquired using a Spectral Dimensions MatrixNIR camera with a spectral range of 960-1662 nm and a sisuChema SWIR (short wave infrared) hyperspectral pushbroom imaging system with a spectral range of 1000-2498 nm. Exploratory principal component analysis (PCA) was used on absorbance images to remove background, bad pixels and shading. On the cleaned images, PCA could be used effectively to find histological classes including glassy (hard) and floury (soft) endosperm. PCA illustrated a distinct difference between glassy and floury endosperm along principal component (PC) three on the MatrixNIR and PC two on the sisuChema with two distinguishable clusters. Subsequently partial least squares discriminant analysis (PLS-DA) was applied to build a classification model. The PLS-DA model from the MatrixNIR image (12 kernels) resulted in root mean square error of prediction (RMSEP) value of 0.18. This was repeated on the MatrixNIR image of the 24 kernels which resulted in RMSEP of 0.18. The sisuChema image yielded RMSEP value of 0.29. The reproducible results obtained with the different data sets indicate that the method proposed in this paper has a real potential for future classification uses.

  8. NIR-to-NIR Two-Photon Scanning Laser Microscopy Imaging of Single Nanoparticles Doped by Yb(III) Complexes.

    Science.gov (United States)

    Bourdolle, Adrien; D'Aléo, Anthony; Philippot, Cécile; Baldeck, Patrice L; Guyot, Yannick; Dubois, Fabien; Ibanez, Alain; Andraud, Chantal; Brasselet, Sophie; Maury, Olivier

    2016-01-04

    The photophysical and nonlinear optical properties of water-soluble chromophore-functionalised tris-dipicolinate complexes [LnL3](3-) (Ln=Yb and Nd) are thoroughly studied, revealing that only the Yb(III) luminescence can be sensitized by a two-photon excitation process. The stability of the complex in water is strongly enhanced by embedding in dispersible organosilicate nanoparticles (NPs). Finally, the spectroscopic properties of [NBu4]3 [YbL3] are studied in solution and in the solid state. The high brightness of the NPs allows imaging them as single objects using a modified two-photon microscopy setup in a NIR-to-NIR configuration.

  9. Classification of maize kernels using NIR hyperspectral imaging.

    Science.gov (United States)

    Williams, Paul J; Kucheryavskiy, Sergey

    2016-10-15

    NIR hyperspectral imaging was evaluated to classify maize kernels of three hardness categories: hard, medium and soft. Two approaches, pixel-wise and object-wise, were investigated to group kernels according to hardness. The pixel-wise classification assigned a class to every pixel from individual kernels and did not give acceptable results because of high misclassification. However by using a predefined threshold and classifying entire kernels based on the number of correctly predicted pixels, improved results were achieved (sensitivity and specificity of 0.75 and 0.97). Object-wise classification was performed using two methods for feature extraction - score histograms and mean spectra. The model based on score histograms performed better for hard kernel classification (sensitivity and specificity of 0.93 and 0.97), while that of mean spectra gave better results for medium kernels (sensitivity and specificity of 0.95 and 0.93). Both feature extraction methods can be recommended for classification of maize kernels on production scale.

  10. High-Contrast NIR Polarization Imaging of MWC480

    Science.gov (United States)

    McElwain, M. W.; Kusakabe, N.; Hashimoto, J.; Kudo, T.; Kandori, R.; Miyama, S.; Morino, J.-I.; Suto, H.; Suzuki, R.; Tamura, M.; Grady, C. A.; Sitko, M. L.; Werren, C.; Day, A. N.; Beerman, C.; Iye, M.; Lynch, D. K.; Russell, R. W.; Brafford, S. M.

    2012-01-01

    One of the key predictions of modeling from the IR excess of Herbig Ae stars is that for protoplanetary disks, where significant grain growth and settling has occurred, the dust disk has flattened to the point that it can be partially or largely shadowed by the innermost material at or near the dust sublimation radius. When the self-shadowing has already started, the outer disk is expected to be detected in scattered light only in the exceptional cases that the scale height of the dust disk at the sublimation radius is smaller than usual. High-contrast imaging combined with the IR spectral energy distribution allow us to measure the degree of flattening of the disk, as well as to determine the properties of the outer disk. We present polarimetric differential imaging in H band obtained with Subaru/HiCIAO of one such system, MWC 480. The HiCIAO data were obtained at a historic minimum of the NIR excess. The disk is detected in scattered light from 0".2-1"0 (27.4-137 AU). Together with the marginal detection of the disk from 1998 February 24 by HST / NICMOS, our data constrain the opening half angle for the disk to lie between 1.3 <= Theta <=2.2 deg. When compared with similar measures in CO for the gas disk from the literature, the dust disk subtends only approx 30% of the gas disk scale height (H/R approx 0. 03). Such a dust disk is a factor of 5-7 flatter than transitional disks, which have structural signatures that giant planets have formed.

  11. A compact bio-inspired visible/NIR imager for image-guided surgery (Conference Presentation)

    Science.gov (United States)

    Gao, Shengkui; Garcia, Missael; Edmiston, Chris; York, Timothy; Marinov, Radoslav; Mondal, Suman B.; Zhu, Nan; Sudlow, Gail P.; Akers, Walter J.; Margenthaler, Julie A.; Liang, Rongguang; Pepino, Marta; Achilefu, Samuel; Gruev, Viktor

    2016-03-01

    Inspired by the visual system of the morpho butterfly, we have designed, fabricated, tested and clinically translated an ultra-sensitive, light weight and compact imaging sensor capable of simultaneously capturing near infrared (NIR) and visible spectrum information. The visual system of the morpho butterfly combines photosensitive cells with spectral filters at the receptor level. The spectral filters are realized by alternating layers of high and low dielectric constant, such as air and cytoplasm. We have successfully mimicked this concept by integrating pixelated spectral filters, realized by alternating silicon dioxide and silicon nitrate layers, with an array of CCD detectors. There are four different types of pixelated spectral filters in the imaging plane: red, green, blue and NIR. The high optical density (OD) of all spectral filters (OD>4) allow for efficient rejections of photons from unwanted bands. The single imaging chip weighs 20 grams with form factor of 5mm by 5mm. The imaging camera is integrated with a goggle display system. A tumor targeted agent, LS301, is used to identify all spontaneous tumors in a transgenic PyMT murine model of breast cancer. The imaging system achieved sensitivity of 98% and selectivity of 95%. We also used our imaging sensor to locate sentinel lymph nodes (SLNs) in patients with breast cancer using indocyanine green tracer. The surgeon was able to identify 100% of SLNs when using our bio-inspired imaging system, compared to 93% when using information from the lymphotropic dye and 96% when using information from the radioactive tracer.

  12. Investigation of NIR hyperspectral imaging for discriminating melamine in milk powder

    Science.gov (United States)

    Fu, Xiaping; Kim, Moon S.; Chao, Kuanglin; Qin, Jianwei; Lim, Jongguk; Lee, Hoyoung; Ying, Yibin

    2013-05-01

    Melamine (2,4,6-triamino-1,3,5-triazine) contamination of food has become an urgent and broadly recognized issue for which rapid and accurate identification methods are needed by the food industry. In this study, the feasibility and effectiveness of near-infrared (NIR) hyperspectral imaging was investigated for detecting melamine in milk powder. Hyperspectral NIR images (144 bands spanning from 990 to 1700 nm) were acquired for Petri dishes containing samples of milk powder mixed with melamine at various concentrations (0.02% to 1%). Spectral bands that showed the most significant differences between pure milk and pure melamine were selected, and two-band difference analysis was applied to the spectrum of each pixel in the sample images to identify melamine particles in milk powders. The resultant images effectively allowed visualization of melamine particle distributions in the samples. The study demonstrated that NIR hyperspectral imaging techniques can qualitatively and quantitatively identify melamine adulteration in milk powders.

  13. Next generation NIR fluorophores for tumor imaging and fluorescence-guided surgery: A review.

    Science.gov (United States)

    Haque, Ashanul; Faizi, Md Serajul Haque; Rather, Jahangir Ahmad; Khan, Muhammad S

    2017-04-01

    Cancer is a group of diseases responsible for the major causes of mortality and morbidity among people of all ages. Even though medical sciences have made enormous growth, complete treatment of this deadly disease is still a challenging task. Last few decades witnessed an impressive growth in the design and development of near infrared (NIR) fluorophores with and without recognition moieties for molecular recognitions, imaging and image guided surgeries. The present article reviews recently reported NIR emitting organic/inorganic fluorophores that targets and accumulates in organelle/organs specifically for molecular imaging of cancerous cells. Near infrared (NIR probe) with or without a tumor-targeting warhead have been considered and discussed for their applications in the field of cancer imaging. In addition, challenges persist in this area are also delineated in this review.

  14. Pancreas-targeted NIR fluorophores for dual-channel image-guided abdominal surgery.

    Science.gov (United States)

    Wada, Hideyuki; Hyun, Hoon; Vargas, Christina; Gravier, Julien; Park, GwangLi; Gioux, Sylvain; Frangioni, John V; Henary, Maged; Choi, Hak Soo

    2015-01-01

    Pancreas-related complications are some of the most serious ones in abdominal surgery. The goal of this study was to develop and validate novel near-infrared (NIR) fluorophores that would enable real-time pancreas imaging to avoid the intraoperative pancreatic injury. After initial screening of a large NIR fluorophore library, the performance of 3 selected pancreas-targeted 700 nm NIR fluorophores, T700-H, T700-F, and MB, were quantified in mice, rats, and pigs. Dose ranging using 25 and 100 nmol, and 2.5 µmol of T700-F, and its imaging kinetics over a 4 h period were tested in each species. Three different 800 nm NIR fluorophores were employed for dual-channel FLARE™ imaging in pigs: 2 μmol of ZW800-1 for vessels and kidney, 1 μmol of ZW800-3C for lymph nodes, and 2 μmol of ESNF31 for adrenal glands. T700-F demonstrated the highest signal to background ratio (SBR), with peak SBR at 4 h postinjection in mice. In pigs, T700-F produced an SBR≥2 against muscle, spleen, and lymph nodes for up to 8 h after a single intravenous injection. The combination of T700-F with each 800 nm NIR fluorophore provided simultaneous dual-channel intraoperative imaging of pancreas with surrounding organs in real time. Pancreas-targeted NIR fluorophores combined with the FLARE dual-channel imaging system enable the real-time intraoperative pancreas imaging which helps surgeons perform safer and more curative abdominal surgeries.

  15. Recent progress of near-infrared (NIR) imaging--development of novel instruments and their applicability for practical situations--.

    Science.gov (United States)

    Ishikawa, Daitaro; Shinzawa, Hideyuki; Genkawa, Takuma; Kazarian, Sergei G; Ozaki, Yukihiro

    2014-01-01

    The purpose of this review article is to outline the recent progress in near-infrared (NIR) imaging technology with particular emphasis on new instrumentation. Superior features of NIR imaging such as suitability for nondestructive and in-situ analysis, transmission ability, availability of optical fibers, high-speed monitoring and stability are very attractive not only for laboratory-based studies but also for diverse practical applications. In this review, introduction to chemical imaging is described, and then, a comparison among NIR, infrared (IR) and Raman imaging are made. Furthermore, the features of new NIR imaging instruments developed by our research group in collaboration with Yokogawa Electric Corporation and Sumitomo Electric Industries, Ltd. are discussed. Finally, some examples of applications of NIR imaging are introduced. Particularly, the performance and usefulness of the newly-developed imaging devices are demonstrated through their applications to pharmaceutical tablets and polymers.

  16. Corticospinal excitability changes to anodal tDCS elucidated with NIRS-EEG joint-imaging

    DEFF Research Database (Denmark)

    Jindal, Utkarsh; Sood, Mehak; Chowdhury, Shubhajit Roy;

    2015-01-01

    Transcranial direct current stimulation (tDCS) has been shown to modulate corticospinal excitability. We used near-infrared spectroscopy (NIRS) - electroencephalography (EEG) joint-imaging during and after anodal tDCS to measure changes in mean cerebral haemoglobin oxygen saturation (rSO2) along...... with changes in the log-transformed mean-power of EEG within 0.5 Hz - 11.25 Hz. In two separate studies, we investigated local post-tDCS alterations from baseline at the site of anodal tDCS using NIRS-EEG/tDCS joint-imaging as well as local post-tDCS alterations in motor evoked potentials (MEP...... that the innovative technologies for portable NIRS-EEG neuroimaging may be leveraged to objectively quantify the progress (e.g., corticospinal excitability alterations) and dose tDCS intervention as an adjuvant treatment during neurorehabilitation....

  17. MAJIS (Moons and Jupiter Imaging Spectrometer): the VIS-NIR imaging spectrometer of the JUICE mission

    Science.gov (United States)

    Langevin, Yves; Piccioni, Giuseppe; Dumesnil, Cydalise; Filacchione, Gianrico; Poulet, Francois; MAJIS Team

    2016-10-01

    MAJIS is the VIS-NIR imaging spectrometer of JUICE. This ambitious mission of ESA's « cosmic vision » program will investigate Jupiter and its system with a specific focus on Ganymede. After a tour of more than 3 years including 2 fly-bys of Europa and up to 20 flybys of Ganymede and Callisto, the end of the nominal mission will be dedicated to an orbital phase around Ganymede with 120 days in a near-circular, near-polar orbit at an altitude of 5000 km and 130 days in a circular near-polar orbit at an altitude of 500 km. MAJIS will adress 17 of the 19 primary science objectives of JUICE, investigating the surface and exosphere of the Galilean satellites (Ganymede during the orbital phase, Europa and Callisto during close flybys, Io from a minimum distance of 570,000 km), the atmosphere / exosphere of Jupiter, small satellites and rings, and their role as sources and sinks of particles in the Jupiter magnetosphere.The main technical characteristics are the following:Spectral range : 0.5 - 5.7 µm with two overlapping channels (VIS-NIR : 0.5 - 2.35 µm ; IR : 2.25 - 5.7 µm)Spatial resolution : 0.125 to 0.15 mradSpectral sampling (VIS-NIR channel) : 2.9 to 3.45 nmSpectral sampling (IR channel) : 5.4 to 6.45 nmThe spectral and spatial resolution will be finalized in october 2016 after the selection of the MAJIS detectors.Passive cooling will provide operating temperatures noise model will be larger than 100 over most of the spectral range except for high resolution observations of icy moons at low altitude due to limitations on the integration time even with motion compensation provided by a scanner and for exospheric observations due to intrinsic low signal levels.

  18. Rare earths based nir luminomagnetic nanoparticles and their multimodal applications in biomedical imaging

    Science.gov (United States)

    Mimun, L. Christopher

    Medical imaging is one of the most important techniques in the medical field for diagnostics and analysis of biological tissues. The most common imaging modalities are X-ray, Magnetic Resonance Imaging (MRI), and optical imaging. In each of these imaging techniques, several contrast agents are used to improve the image resolution. There are several contrast agents available that are specific for a particular application and only include one functionality. In addition, most of the contrast agents available today have several limitations such as low image resolution, low thermal stability, toxicity, cost of production etc. The development of an ideal contrast agent with multiple functionalities that overcome most of these limitations is a challenging topic in the medical industry. Furthermore, by adding multiple functionalities into a single contrast agent the benefits would provide a decrease in cost and time by imaging multiple modalities simultaneously. Though there are various attempts in this area by several researchers around the world, the idea of developing a core-shell free multifunctional contrast agent with near infrared (NIR) imaging features and magnetic properties is novel. This doctoral dissertation is focused on the investigation of rare earth doped, NIR active, luminomagnetic nanocrystals (NCs) that have the potential to be effective contrast with multiple modalities. The main content of the thesis is about the development, characterization, and implementation of Nd 3+ doped YF3, GdF3, and Na(Lu0.5Gd 0.5)F4. The "as prepared" and surface functionalized NCs are characterized for their phase, morphology, and detailed optical characteristics such as absorption, emission and quantum yield. Magnetic properties are studied by magnetization experiments. In order to show the proof of concept as a multifunctional imaging agent various imaging experiments such as confocal intracellular imaging, NIR optical imaging, X-ray imaging and magnetic resonance imaging

  19. Comparison of NIR chemical imaging with conventional NIR, Raman and ATR-IR spectroscopy for quantification of furosemide crystal polymorphs in ternary powder mixtures.

    Science.gov (United States)

    Schönbichler, S A; Bittner, L K H; Weiss, A K H; Griesser, U J; Pallua, J D; Huck, C W

    2013-08-01

    The aim of this study was to evaluate the ability of near-infrared chemical imaging (NIR-CI), near-infrared (NIR), Raman and attenuated-total-reflectance infrared (ATR-IR) spectroscopy to quantify three polymorphic forms (I, II, III) of furosemide in ternary powder mixtures. For this purpose, partial least-squares (PLS) regression models were developed, and different data preprocessing algorithms such as normalization, standard normal variate (SNV), multiplicative scatter correction (MSC) and 1st to 3rd derivatives were applied to reduce the influence of systematic disturbances. The performance of the methods was evaluated by comparison of the standard error of cross-validation (SECV), R(2), and the ratio performance deviation (RPD). Limits of detection (LOD) and limits of quantification (LOQ) of all methods were determined. For NIR-CI, a SECVcorr-spec and a SECVsingle-pixel corrected were calculated to assess the loss of accuracy by taking advantage of the spatial information. NIR-CI showed a SECVcorr-spec (SECVsingle-pixel corrected) of 2.82% (3.71%), 3.49% (4.65%), and 4.10% (5.06%) for form I, II, III. NIR had a SECV of 2.98%, 3.62%, and 2.75%, and Raman reached 3.25%, 3.08%, and 3.18%. The SECV of the ATR-IR models were 7.46%, 7.18%, and 12.08%. This study proves that NIR-CI, NIR, and Raman are well suited to quantify forms I-III of furosemide in ternary mixtures. Because of the pressure-dependent conversion of form II to form I, ATR-IR was found to be less appropriate for an accurate quantification of the mixtures. In this study, the capability of NIR-CI for the quantification of polymorphic ternary mixtures was compared with conventional spectroscopic techniques for the first time. For this purpose, a new way of spectra selection was chosen, and two kinds of SECVs were calculated to achieve a better comparability of NIR-CI to NIR, Raman, and ATR-IR.

  20. NIR Hyperspectral Imaging Measurement of Sugar Content in Peach Using PLS Regression

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Near infrared (NIR) hyperspectral imaging measurement of sugar content in peach was introduced. NIR spectral images (650~ 1 000 nm, resolution: 2 nm) of peach samples were captured with developed hyperspectral imaging setup. Partial least square (PLS) regression prediction model was developed to estimate the sugar content in peach; step-wise backward method was utilized to determine optimal wavelength subsets. Experimental results show that the calibration model with optimal wavelength subsets has a correlation coefficient of prediction of 0.97 and a standard error of prediction of 0.19, the prediction accuracy is higher than the calibration model applied over the whole wavelength, which proves that variable selection plays an important role in improving the prediction accuracy of PLS regression model.

  1. Concurrent MR-NIR Imaging for Breast Cancer Diagnosis

    Science.gov (United States)

    2007-06-01

    Schwinger -type equations [10] using Born approximation [15]. Furthermore, the error analysis introduced in this paper is not limited to DOT, and can...the effect of linearization of the Lippmann– Schwinger -type equations [10] using Born approximation on the accuracy of the reconstructed optical images

  2. Appropriate Tealeaf Harvest Timing Determination Referring Fiber Content in Tealeaf Derived from Ground based Nir Camera Images

    Directory of Open Access Journals (Sweden)

    Kohei Arai

    2015-08-01

    Full Text Available Method for most appropriate tealeaves harvest timing with the reference to the fiber content in tealeaves which can be estimated with ground based Near Infrared (NIR camera images is proposed. In the proposed method, NIR camera images of tealeaves are used for estimation of nitrogen content and fiber content in tealeaves. The nitrogen content is highly correlated to Theanine (amid acid content in tealeaves. Theanine rich tealeaves taste good. Meanwhile, the age of tealeaves depend on fiber content. When tealeaves are getting old, then fiber content is increased. Tealeaf shape volume also is increased with increasing of fiber content. Fiber rich tealeaves taste not so good, in general. There is negative correlation between fiber content and NIR reflectance of tealeaves. Therefore, tealeaves quality of nitrogen and fiber contents can be estimated with NIR camera images. Also, the shape volume of tealeaves is highly correlated to NIR reflectance of tealeaf surface. Therefore, not only tealeaf quality but also harvest amount can be estimated with NIR camera images. Experimental results show the proposed method works well for estimation of appropriate tealeaves harvest timing with fiber content in the tealeaves in concern estimated with NIR camera images.

  3. Concurrent MR-NIR Imaging for Breast Cancer Diagnosis

    Science.gov (United States)

    2005-06-01

    significantly different than the true optical coefficients of tissue. As a result, the assumption of strong optical-anatomy correlation may cause ...assumption of strong optical-anatomy correlation may cause undesirable, erroneous bias in optical image reconstruction. Therefore, more flexible prior models...378, 1999. 22 TABLE I FOUR-COMPARTMENT MODEL:ESTIMATED PHARMACOKINETIC PARAMETERS USING EKF ALGORITHM kak ckd 4 k f kout (Sec-1 10-2) (seC- 1 10-2

  4. Modeling and tissue parameter extraction challenges for free space broadband fNIR brain imaging systems

    Science.gov (United States)

    Sultan, E.; Manseta, K.; Khwaja, A.; Najafizadeh, L.; Gandjbakhche, A.; Pourrezaei, K.; Daryoush, A. S.

    2011-02-01

    Fiber based functional near infra-red (fNIR) spectroscopy has been considered as a cost effective imaging modality. To achieve a better spatial resolution and greater accuracy in extraction of the optical parameters (i.e., μa and μ's), broadband frequency modulated systems covering multi-octave frequencies of 10-1000MHz is considered. A helmet mounted broadband free space fNIR system is considered as significant improvement over bulky commercial fiber fNIR realizations that are inherently uncomfortable and dispersive for broadband operation. Accurate measurements of amplitude and phase of the frequency modulated NIR signals (670nm, 795nm, and 850nm) is reported here using free space optical transmitters and receivers realized in a small size and low cost modules. The tri-wavelength optical transmitter is based on vertical cavity semiconductor lasers (VCSEL), whereas the sensitive optical receiver is based on either PIN or APD photodiodes combined with transimpedance amplifiers. This paper also has considered brain phantoms to perform optical parameter extraction experiments using broadband modulated light for separations of up to 5cm. Analytical models for predicting forward (transmittance) and backward (reflectance) scattering of modulated photons in diffused media has been modeled using Diffusion Equation (DE). The robustness of the DE modeling and parameter extraction algorithm was studied by experimental verification of multi-layer diffused media phantoms. In particular, comparison between analytical and experimental models for narrow band and broadband has been performed to analyze the advantages of our broadband fNIR system.

  5. EMIR, the GTC NIR multi-object imager-spectrograph

    Science.gov (United States)

    Garzón, F.; Abreu, D.; Barrera, S.; Becerril, S.; Cairós, L. M.; Díaz, J. J.; Fragoso, A. B.; Gago, F.; Grange, R.; González, C.; López, P.; Patrón, J.; Pérez, J.; Rasilla, J. L.; Redondo, P.; Restrepo, R.; Saavedra, P.; Sánchez, V.; Tenegi, F.; Vallbé, M.

    2007-06-01

    EMIR, currently entering into its fabrication and AIV phase, will be one of the first common user instruments for the GTC, the 10 meter telescope under construction by GRANTECAN at the Roque de los Muchachos Observatory (Canary Islands, Spain). EMIR is being built by a Consortium of Spanish and French institutes led by the Instituto de Astrofísica de Canarias (IAC). EMIR is designed to realize one of the central goals of 10m class telescopes, allowing observers to obtain spectra for large numbers of faint sources in a time-efficient manner. EMIR is primarily designed to be operated as a MOS in the K band, but offers a wide range of observing modes, including imaging and spectroscopy, both long slit and multi-object, in the wavelength range 0.9 to 2.5 μm. It is equipped with two innovative subsystems: a robotic reconfigurable multi-slit mask and dispersive elements formed by the combination of high quality diffraction grating and conventional prisms, both at the heart of the instrument. The present status of development, expected performances, schedule and plans for scientific exploitation are described and discussed. The development and fabrication of EMIR is funded by GRANTECAN and the Plan Nacional de Astronomía y Astrofísica (National Plan for Astronomy and Astrophysics, Spain).

  6. Efficient Dual-Modal NIR-to-NIR Emission of Rare Earth Ions Co-doped Nanocrystals for Biological Fluorescence Imaging.

    Science.gov (United States)

    Zhou, Jiajia; Shirahata, Naoto; Sun, Hong-Tao; Ghosh, Batu; Ogawara, Makoto; Teng, Yu; Zhou, Shifeng; Sa Chu, Rong Gui; Fujii, Minoru; Qiu, Jianrong

    2013-02-07

    A novel approach has been developed for the realization of efficient near-infrared to near-infrared (NIR-to-NIR) upconversion and down-shifting emission in nanophosphors. The efficient dual-modal NIR-to-NIR emission is realized in a β-NaGdF4/Nd(3+)@NaGdF4/Tm(3+)-Yb(3+) core-shell nanocrystal by careful control of the identity and concentration of the doped rare earth (RE) ion species and by manipulation of the spatial distributions of these RE ions. The photoluminescence results reveal that the emission efficiency increases at least 2-fold when comparing the materials synthesized in this study with those synthesized through traditional approaches. Hence, these core-shell structured nanocrystals with novel excitation and emission behaviors enable us to obtain tissue fluorescence imaging by detecting the upconverted and down-shifted photoluminescence from Tm(3+) and Nd(3+) ions, respectively. The reported approach thus provides a new route for the realization of high-yield emission from RE ion doped nanocrystals, which could prove to be useful for the design of optical materials containing other optically active centers.

  7. Visualization and prediction of porosity in roller compacted ribbonswith near infrared chemical imaging (NIR-CI)

    DEFF Research Database (Denmark)

    Khorasani, Milad Rouhi; Amigo Rubio, Jose Manuel; Sonnergaard, Jørn

    2015-01-01

    The porosity of roller compacted ribbon is recognized as an important critical quality attribute which has a huge impact on the final product quality. The purpose of this study was to investigate the use of near-infrared chemical imaging (NIR-CI) for porosity estimation of ribbons produced...... at different roll pressures. Two off-line methods were utilized as reference methods. The relatively fast method (oil absorption) was comparable with the more time-consuming mercury intrusion method (R2 = 0.98). Therefore, the oil method was selected as the reference off line method. It was confirmed by both...... reference methods that ribbons compressed at a higher pressure resulted in a lower mean porosity. Using NIR-CI in combination with multivariate data analysis it was possible to visualize and predict the porosity distribution of the ribbons. This approach is considered important for process monitoring...

  8. Functional imaging of muscle oxygenation using a 200-channel cw NIRS system

    Science.gov (United States)

    Yamamoto, Katsuyuki; Niwayama, Masatsugu; Kohata, Daisuke; Kudo, Nobuki; Hamaoka, Takatumi; Kime, Ryotaro; Katsumura, Toshihito

    2001-06-01

    Functional imaging of muscle oxygenation using NIRS is a promising technique for evaluation of the heterogeneity of muscle function and diagnosis of peripheral vascular disease or muscle injury. We have developed a 200-channel imaging system that can measure the changes in oxygenation and blood volume of muscles and that covers wider area than previously reported systems. Our system consisted of 40 probes, a multiplexer for switching signals to and from the probes, and a personal computer for obtaining images. In each probe, one two-wavelength LED (770 and 830 nm) and five photodiodes were mounted on a flexible substrate. In order to eliminate the influence of a subcutaneous fat layer, a correction method, which we previously developed, was also used in imaging. Thus, quantitative changes in concentrations of oxy- and deoxy-hemoglobin were obtained. Temporal resolution was 1.5 s and spatial resolution was about 20 mm, depending on probe separations. Exercise tests (isometric contraction of 50% MVC) on the thigh with and without arterial occlusion were conducted, and changes in muscle oxygenation were imaged using the developed system. Results showed that the heterogeneity of deoxygenation and reoxygenation during exercise and recovery periods, respectively, were clearly observed. These results suggest that optical imaging of dynamic change in muscle oxygenation using NIRS would be useful not only for basic physiological studies but also for clinical applications with respect to muscle functions.

  9. A Highly Photostable Hyperbranched Polyglycerol-Based NIR Fluorescence Nanoplatform for Mitochondria-Specific Cell Imaging.

    Science.gov (United States)

    Dong, Chunhong; Liu, Zhongyun; Liu, Junqing; Wu, Changzhu; Neumann, Falko; Wang, Hanjie; Schäfer-Korting, Monika; Kleuser, Burkhard; Chang, Jin; Li, Wenzhong; Ma, Nan; Haag, Rainer

    2016-09-01

    Considering the critical role of mitochondria in the life and death of cells, non-invasive long-term tracking of mitochondria has attracted considerable interest. However, a high-performance mitochondria-specific labeling probe with high photostability is still lacking. Herein a highly photostable hyperbranched polyglycerol (hPG)-based near-infrared (NIR) quantum dots (QDs) nanoplatform is reported for mitochondria-specific cell imaging. Comprising NIR Zn-Cu-In-S/ZnS QDs as extremely photostable fluorescent labels and alkyl chain (C12 )/triphenylphosphonium (TPP)-functionalized hPG derivatives as protective shell, the tailored QDs@hPG-C12 /TPP nanoprobe with a hydrodynamic diameter of about 65 nm exhibits NIR fluorescence, excellent biocompatibility, good stability, and mitochondria-targeted ability. Cell uptake experiments demonstrate that QDs@hPG-C12 /TPP displays a significantly enhanced uptake in HeLa cells compared to nontargeted QDs@hPG-C12 . Further co-localization study indicates that the probe selectively targets mitochondria. Importantly, compared with commercial deep-red mitochondria dyes, QDs@hPG-C12 /TPP possesses superior photostability under continuous laser irradiation, indicating great potential for long-term mitochondria labeling and tracking. Moreover, drug-loaded QDs@hPG-C12 /TPP display an enhanced tumor cell killing efficacy compared to nontargeted drugs. This work could open the door to the construction of organelle-targeted multifunctional nanoplatforms for precise diagnosis and high-efficient tumor therapy.

  10. A Calibration Method Based on Linear InGaAs in Fiber Grating Sensors Interrogation System

    Institute of Scientific and Technical Information of China (English)

    TAO Jun; ZHANG Xia

    2009-01-01

    In accordance with the characteristics of wavelength shift detection in fiber grating sensor interrogation system, the wavelength interrogation system which uses linear InGaAs as the spectrum receiver is proposed. Orientation of optic spectrum line affects the silt of volume phase grating and size of InGaAs photosensitive unit, thus the calibration method is needed. Based on an analysis of InGaAs imaging model, least square curve fitting method is proposed to detect spectrum wavelength and InGaAs photosensitive unit position. The experimental results show that the methods are effective and the demodulation system precision is improved.

  11. Mapping of TBARS distribution in frozen-thawed pork using NIR hyperspectral imaging.

    Science.gov (United States)

    Wu, Xiang; Song, Xinglin; Qiu, Zhengjun; He, Yong

    2016-03-01

    In this study, NIR hyperspectral imaging technology was applied to determine the distribution of TBARS in frozen-thawed pork. A total of 240 fresh pork samples were assigned to 4 treatment groups (0, 1, 3, 5 frozen-thawed cycles). For each sample, a hyperspectral image (874-1734nm) was collected, followed by chemical TBARS analysis. Successive projection algorithm (SPA) was applied to choose effective wavelengths (EWs). The selected 13 EWs of the calibration set and relevant TBARS value were used as inputs of partial least squares regression (PLSR) model, yielding correlation coefficient of prediction of 0.81 and root mean square error of prediction of 0.33. The developed PLSR model were applied pixel-wise to produce chemical maps of TBARS for 24 selected samples in the prediction set. The results indicated that NIR hyperspectral imaging combined with image processing has the potential to visualize TBARS distribution in frozen-thawed pork. This technique could be useful in real-time quality monitoring in meat industry.

  12. Simultaneous fNIRS and thermal infrared imaging during cognitive task reveal autonomic correlates of prefrontal cortex activity

    Science.gov (United States)

    Pinti, Paola; Cardone, Daniela; Merla, Arcangelo

    2015-12-01

    Functional Near Infrared-Spectroscopy (fNIRS) represents a powerful tool to non-invasively study task-evoked brain activity. fNIRS assessment of cortical activity may suffer for contamination by physiological noises of different origin (e.g. heart beat, respiration, blood pressure, skin blood flow), both task-evoked and spontaneous. Spontaneous changes occur at different time scales and, even if they are not directly elicited by tasks, their amplitude may result task-modulated. In this study, concentration changes of hemoglobin were recorded over the prefrontal cortex while simultaneously recording the facial temperature variations of the participants through functional infrared thermal (fIR) imaging. fIR imaging provides touch-less estimation of the thermal expression of peripheral autonomic. Wavelet analysis revealed task-modulation of the very low frequency (VLF) components of both fNIRS and fIR signals and strong coherence between them. Our results indicate that subjective cognitive and autonomic activities are intimately linked and that the VLF component of the fNIRS signal is affected by the autonomic activity elicited by the cognitive task. Moreover, we showed that task-modulated changes in vascular tone occur both at a superficial and at larger depth in the brain. Combined use of fNIRS and fIR imaging can effectively quantify the impact of VLF autonomic activity on the fNIRS signals.

  13. SWIR InGaAs focal plane arrays in France

    Science.gov (United States)

    Rouvié, A.; Huet, O.; Hamard, S.; Truffer, J. P.; Pozzi, M.; Decobert, J.; Costard, E.; Zécri, M.; Maillart, P.; Reibel, Y.; Pécheur, A.

    2013-06-01

    SWIR detection band benefits from natural (sun, night glow, thermal radiation) or artificial (eye safe lasers) photons sources combined to low atmospheric absorption and specific contrast compared to visible wavelengths. It gives the opportunity to address a large spectrum of applications such as defense and security (night vision, active imaging), space (earth observation), transport (automotive safety) or industry (non destructive process control). InGaAs material appears as a good candidate to satisfy SWIR detection needs. The lattice matching with InP constitutes a double advantage to this material: attractive production capacity and uncooled operation thanks to low dark current level induced by high quality material. The study of InGaAs FPA has begun few years ago with III-VLab, gathering expertise in InGaAs material growth and imaging technology respectively from Alcatel-Lucent and Thales, its two mother companies. This work has led to put quickly on the market a 320x256 InGaAs module. The recent transfer of imagery activities from III-VLab to Sofradir allows developing new high performances products, satisfying customers' new requirements. Especially, a 640x512 InGaAs module with a pitch of 15µm is actually under development to fill the needs of low light level imaging.

  14. Discrimination methods of biological contamination on fresh-cut lettuce based on VNIR and NIR hyperspectral imaging

    Science.gov (United States)

    Multispectral imaging algorithms were developed using visible-near-infrared (VNIR) and near-infrared (NIR) hyperspectral imaging (HSI) techniques to detect worms on fresh-cut lettuce. The optimal wavebands that detect worm on fresh-cut lettuce for each type of HSI were investigated using the one-way...

  15. Concurrent EEG And NIRS Tomographic Imaging Based on Wearable Electro-Optodes

    Science.gov (United States)

    2014-04-13

    simultaneous electroencephalogram ( EEG ) and functional NIR spectroscopic (fNIRS) acquisition for biological or cognitive neuroscience studies in operational...environments. The system features novel EEG /NIRS electrodes, known as electro-opodes, and miniaturized supporting hardware/software. In the past few...years, our team, composed of faculty, postdoctoral fellows and graduate students, has designed and developed dry EEG and fNIR sensors that allow non

  16. Visible and NIR image fusion using weight-map-guided Laplacian–Gaussian pyramid for improving scene visibility

    Indian Academy of Sciences (India)

    ASHISH V VANMALI; VIKRAM M GADRE

    2017-07-01

    Image visibility is affected by the presence of haze, fog, smoke, aerosol, etc. Image dehazing using either single visible image or visible and near-infrared (NIR) image pair is often considered as a solution to improve the visual quality of such scenes. In this paper, we address this problem from a visible–NIR image fusion perspective, instead of the conventional haze imaging model. The proposed algorithm uses a Laplacian–Gaussian pyramid based multi-resolution fusion process, guided by weight maps generated using local entropy,local contrast and visibility as metrics that control the fusion result. The proposed algorithm is free from any human intervention, and produces results that outperform the existing image-dehazing algorithms both visually as well as quantitatively. The algorithm proves to be efficient not only for the outdoor scenes with or without haze, but also for the indoor scenes in improving scene visibility.

  17. Mineralogical Mapping of Asteroid Itokawa using Calibrated Hayabusa AMICA images and NIRS Spectrometer Data

    Science.gov (United States)

    Le Corre, Lucille; Becker, Kris J.; Reddy, Vishnu; Li, Jian-Yang; Bhatt, Megha

    2016-10-01

    The goal of our work is to restore data from the Hayabusa spacecraft that is available in the Planetary Data System (PDS) Small Bodies Node. More specifically, our objectives are to radiometrically calibrate and photometrically correct AMICA (Asteroid Multi-Band Imaging Camera) images of Itokawa. The existing images archived in the PDS are not in reflectance and not corrected from the effect of viewing geometry. AMICA images are processed with the Integrated Software for Imagers and Spectrometers (ISIS) system from USGS, widely used for planetary image analysis. The processing consists in the ingestion of the images in ISIS (amica2isis), updates to AMICA start time (sumspice), radiometric calibration (amicacal) including smear correction, applying SPICE ephemeris, adjusting control using Gaskell SUMFILEs (sumspice), projecting individual images (cam2map) and creating global or local mosaics. The application amicacal has also an option to remove pixels corresponding to the polarizing filters on the left side of the image frame. The amicacal application will include a correction for the Point Spread Function. The last version of the PSF published by Ishiguro et al. in 2014 includes correction for the effect of scattered light. This effect is important to correct because it can add 10% level in error and is affecting mostly the longer wavelength filters such as zs and p. The Hayabusa team decided to use the color data for six of the filters for scientific analysis after correcting for the scattered light. We will present calibrated data in I/F for all seven AMICA color filters. All newly implemented ISIS applications and map projections from this work have been or will be distributed to the community via ISIS public releases. We also processed the NIRS spectrometer data, and we will perform photometric modeling, then apply photometric corrections, and finally extract mineralogical parameters. The end results will be the creation of pyroxene chemistry and olivine

  18. Near-infrared chemical imaging (NIR-CI) of 3D printed pharmaceuticals.

    Science.gov (United States)

    Khorasani, Milad; Edinger, Magnus; Raijada, Dhara; Bøtker, Johan; Aho, Johanna; Rantanen, Jukka

    2016-12-30

    Hot-melt extrusion and 3D printing are enabling manufacturing approaches for patient-centred medicinal products. Hot-melt extrusion is a flexible and continuously operating technique which is a crucial part of a typical processing cycle of printed medicines. In this work we use hot-melt extrusion for manufacturing of medicinal films containing indomethacin (IND) and polycaprolactone (PCL), extruded strands with nitrofurantoin monohydrate (NFMH) and poly (ethylene oxide) (PEO), and feedstocks for 3D printed dosage forms with nitrofurantoin anhydrate (NFAH), hydroxyapatite (HA) and poly (lactic acid) (PLA). These feedstocks were printed into a prototype solid dosage form using a desktop 3D printer. These model formulations were characterized using near-infrared chemical imaging (NIR-CI) and, more specifically, the image analytical data were analysed using multivariate curve resolution-alternating least squares (MCR-ALS). The MCR-ALS algorithm predicted the spatial distribution of IND and PCL in the films with reasonable accuracy. In the extruded strands both the chemical mapping of the components in the formulation as well as the solid form of the active compound could be visualized. Based on the image information the total nitrofurantoin and PEO contents could be estimated., The dehydration of NFMH to NFAH, a process-induced solid form change, could be visualized as well. It was observed that the level of dehydration increased with increasing processing time (recirculation during the mixing phase of molten PEO and nitrofurantoin). Similar results were achieved in the 3D printed solid dosage forms produced from the extruded feedstocks. The results presented in this work clearly demonstrate that NIR-CI in combination with MCR-ALS can be used for chemical mapping of both active compound and excipients, as well as for visualization of solid form variation in the final product. The suggested NIR-CI approach is a promising process control tool for characterization of

  19. Four Highly Luminous Massive Star Forming Regions in the Norma Spiral Arm II. Deep NIR imaging

    CERN Document Server

    Chavarria, L; Garay, G; Escala, A; Bronfman, L; Lizano, S

    2009-01-01

    We present sensitive NIR (J, H and K) imaging observations toward four luminous massive star forming regions in the Norma Spiral Arm: G324.201+0.119, G328.307+0.432, G329.337+0.147 and G330.949-0.174. We identify three clusters of young stellar objects (YSO) based on surface density diagnostics. We also find that sources detected only in the H and K-bands and with colors corresponding to spectral types earlier than B2, are likely YSOs. We analyze the spatial distribution of stars of different masses and find signatures in two clusters of primordial mass segregation which can't be explained as due to incompleteness effects. We show that dynamic interactions of cluster members with the dense gas from the parent core can explain the observed mass segregation, indicating that the gas plays an important role in the dynamics of young clusters.

  20. Assessment of powder blend uniformity: Comparison of real-time NIR blend monitoring with stratified sampling in combination with HPLC and at-line NIR Chemical Imaging.

    Science.gov (United States)

    Bakri, Barbara; Weimer, Marco; Hauck, Gerrit; Reich, Gabriele

    2015-11-01

    Scope of the study was (1) to develop a lean quantitative calibration for real-time near-infrared (NIR) blend monitoring, which meets the requirements in early development of pharmaceutical products and (2) to compare the prediction performance of this approach with the results obtained from stratified sampling using a sample thief in combination with off-line high pressure liquid chromatography (HPLC) and at-line near-infrared chemical imaging (NIRCI). Tablets were manufactured from powder blends and analyzed with NIRCI and HPLC to verify the real-time results. The model formulation contained 25% w/w naproxen as a cohesive active pharmaceutical ingredient (API), microcrystalline cellulose and croscarmellose sodium as cohesive excipients and free-flowing mannitol. Five in-line NIR calibration approaches, all using the spectra from the end of the blending process as reference for PLS modeling, were compared in terms of selectivity, precision, prediction accuracy and robustness. High selectivity could be achieved with a "reduced" approach i.e. API and time saving approach (35% reduction of API amount) based on six concentration levels of the API with three levels realized by three independent powder blends and the additional levels obtained by simply increasing the API concentration in these blends. Accuracy and robustness were further improved by combining this calibration set with a second independent data set comprising different excipient concentrations and reflecting different environmental conditions. The combined calibration model was used to monitor the blending process of independent batches. For this model formulation the target concentration of the API could be achieved within 3 min indicating a short blending time. The in-line NIR approach was verified by stratified sampling HPLC and NIRCI results. All three methods revealed comparable results regarding blend end point determination. Differences in both mean API concentration and RSD values could be

  1. Automated Cart with VIS/NIR Hyperspectral Reflectance and Fluorescence Imaging Capabilities

    Directory of Open Access Journals (Sweden)

    Alan M. Lefcourt

    2016-12-01

    Full Text Available A system to take high-resolution Visible/Near Infra-Red (VIS/NIR hyperspectral reflectance and fluorescence images in outdoor fields using ambient lighting or a pulsed laser (355 nm, respectively, for illumination purposes was designed, built, and tested. Components of the system include a semi-autonomous cart, a gated-intensified camera, a spectral adapter, a frequency-triple Nd:YAG (Neodymium-doped Yttrium Aluminium Garnet laser, and optics to convert the Gaussian laser beam into a line-illumination source. The front wheels of the cart are independently powered by stepper motors that support stepping or continuous motion. When stepping, a spreadsheet is used to program parameters of image sets to be acquired at each step. For example, the spreadsheet can be used to set delays before the start of image acquisitions, acquisition times, and laser attenuation. One possible use of this functionality would be to establish acquisition parameters to facilitate the measurement of fluorescence decay-curve characteristics. The laser and camera are mounted on an aluminum plate that allows the optics to be calibrated in a laboratory setting and then moved to the cart. The system was validated by acquiring images of fluorescence responses of spinach leaves and dairy manure.

  2. Functional brain imaging with a supercontinuum time-domain NIRS system

    Science.gov (United States)

    Selb, Juliette; Zimmermann, Bernhard B.; Martino, Mark; Ogden, Tyler; Boas, David A.

    2013-03-01

    We have developed the second generation of our time-domain near-infrared spectroscopy (TD-NIRS) system for baseline and functional brain imaging. The instrument uses a pulsed broadband supercontinuum laser emitting a large spectrum between 650 and 1700 nm, and a gated detection based on an intensified CCD camera. The source laser beam is split into two arms, below and above 776 nm. In each arm, a fast motorized filter wheel enables selection of a bandpass filter at the required wavelength. Each filtered laser beam is then launched into one array of source fibers. The multiplexing through the array of fibers is implemented through a very compact home-made design consisting of two galvanometer mirrors followed by an achromatic doublet. Source fibers are then recombined one-by-one from both arms into the source optodes to be positioned on the head. The detection fibers are all imaged in parallel through a relay lens on an intensified CCD camera. By using detection fibers of different lengths, we introduce optical delays that enable simultaneous recording in different delay windows of the temporal point spread functions. We present the instrumentation and show its preliminary functional imaging capabilities. We also introduce a new probe where we use different fiber lengths on the source and the detector sides in order to record simultaneously both wavelengths from one location through different sets of fibers.

  3. Radiation-Hardened, Substrate-Removed, Metamorphic InGaAs Detector Arrays Project

    Data.gov (United States)

    National Aeronautics and Space Administration — High-performance radiation-hardened metamorphic InGaAs imaging arrays sensitive from the ultraviolet (UV) through the short-wavelength infrared (SWIR) will be...

  4. Photocleavable Hydrogel-Coated Upconverting Nanoparticles: A Multifunctional Theranostic Platform for NIR Imaging and On-Demand Macromolecular Delivery.

    Science.gov (United States)

    Jalani, Ghulam; Naccache, Rafik; Rosenzweig, Derek H; Haglund, Lisbet; Vetrone, Fiorenzo; Cerruti, Marta

    2016-01-27

    Lanthanide-doped upconverting nanoparticles (UCNPs) have emerged as excellent nanotransducers for converting longer wavelength near-infrared (NIR) light to shorter wavelengths spanning the ultraviolet (UV) to the visible (Vis) regions of the spectrum via a multiphoton absorption process, known as upconversion. Here, we report the development of NIR to UV-Vis-NIR UCNPs consisting of LiYF4:Yb(3+)/Tm(3+)@SiO2 individually coated with a 10 ± 2 nm layer of chitosan (CH) hydrogel cross-linked with a photocleavable cross-linker (PhL). We encapsulated fluorescent-bovine serum albumin (FITC-BSA) inside the gel. Under 980 nm excitation, the upconverted UV emission cleaves the PhL cross-links and instantaneously liberates the FITC-BSA under 2 cm thick tissue. The release is immediately arrested if the excitation source is switched off. The upconverted NIR light allows for the tracking of particles under the tissue. Nucleus pulposus (NP) cells cultured with UCNPs are viable both in the presence and in the absence of laser irradiation. Controlled drug delivery of large biomolecules and deep tissue imaging make this system an excellent theranostic platform for tissue engineering, biomapping, and cellular imaging applications.

  5. Near-infrared (NIR) fluorescence imaging of head and neck squamous cell carcinoma for fluorescence-guided surgery (Conference Presentation)

    Science.gov (United States)

    Moore, Lindsay; Warram, Jason M.; de Boer, Esther; Carroll, William R.; Morlandt, Anthony; Withrow, Kirk P.; Rosenthal, Eben L.

    2016-03-01

    During fluorescence-guided surgery, a cancer-specific optical probe is injected and visualized using a compatible device intraoperatively to provide visual contrast between diseased and normal tissues to maximize resection of cancer and minimize the resection of precious adjacent normal tissues. Six patients with squamous cell carcinomas of the head and neck region (oral cavity (n=4) or cutaneous (n=2)) were injected with an EGFR-targeting antibody (Cetuximab) conjugated to a near-infrared (NIR) fluorescent dye (IRDye800) 3, 4, or 7 days prior to surgical resection of the cancer. Each patient's tumor was then imaged using a commercially available, open-field NIR fluorescence imaging device each day prior to surgery, intraoperatively, and post-operatively. The mean fluorescence intensity (MFI) of the tumor was calculated for each specimen at each imaging time point. Adjacent normal tissue served as an internal anatomic control for each patient to establish a patient-matched "background" fluorescence. Resected tissues were also imaged using a closed-field NIR imaging device. Tumor to background ratios (TBRs) were calculated for each patient using both devices. Fluorescence histology was correlated with traditional pathology assessment to verify the specificity of antibody-dye conjugate binding. Peak TBRs using the open-field device ranged from 2.2 to 11.3, with an average TBR of 4.9. Peak TBRs were achieved between days 1 and 4. This study demonstrated that a commercially available NIR imaging device suited for intraoperative and clinical use can successfully be used with a fluorescently-labeled dye to delineate between diseased and normal tissue in this single cohort human study, illuminated the potential for its use in fluoresence-guided surgery.

  6. Nondestructive assessment of the severity of occlusal caries lesions with near-infrared imaging at 1310 nm

    Science.gov (United States)

    Lee, Chulsung; Lee, Dustin; Darling, Cynthia L.; Fried, Daniel

    2010-07-01

    The high transparency of dental enamel in the near-infrared (NIR) at 1310 nm can be exploited for imaging dental caries without the use of ionizing radiation. The objective of this study is to determine whether the lesion contrast derived from NIR imaging in both transmission and reflectance can be used to estimate lesion severity. Two NIR imaging detector technologies are investigated: a new Ge-enhanced complementary metal-oxide-semiconductor (CMOS)-based NIR imaging camera, and an InGaAs focal plane array (FPA). Natural occlusal caries lesions are imaged with both cameras at 1310 nm, and the image contrast between sound and carious regions is calculated. After NIR imaging, teeth are sectioned and examined using polarized light microscopy (PLM) and transverse microradiography (TMR) to determine lesion severity. Lesions are then classified into four categories according to lesion severity. Lesion contrast increases significantly with lesion severity for both cameras (pequipped with the larger array and smaller pixels yields higher contrast values compared with the smaller InGaAs FPA (p<0.01). Results demonstrate that NIR lesion contrast can be used to estimate lesion severity.

  7. Ripening of single-layer InGaAs islands on GaAs (001)

    Institute of Scientific and Technical Information of China (English)

    Liu Ke; Zhou Qing; Zhou Xun; Guo Xiang; Luo Zi-Jiang; Wang Ji-Hong; Hu Ming-Zhe

    2013-01-01

    The present paper discusses our investigation of InGaAs surface morphology annealed for different lengths of time.After annealing for 15 rmin,the ripening of InGaAs islands is completed.The real space scanning tunneling microscopy (STM) images show the evolution of InGaAs surface morphology.A half-terrace diffusion theoretical model based on thermodynamic theory is proposed to estimate the annealing time for obtaining flat morphology.The annealing time calculated by the proposed theory is in agreement with the experimental results.

  8. InGaAs focal plane array developments and perspectives

    Science.gov (United States)

    Rouvié, A.; Coussement, J.; Huet, O.; Truffer, J. P.; Pozzi, M.; Oubensaid, E. H.; Hamard, S.; Chaffraix, V.; Costard, E.

    2015-05-01

    SWIR spectral band is an attractive domain thanks to its intrinsic properties. Close to visible wavelengths, SWIR images interpretation is made easier for field actors. Besides complementary information can be extracted from SWIR band and bring significant added value in several fields of applications such as defense and security (night vision, active imaging), space (earth observation), transport (automotive safety) or industry (non destructive process control). Among the various new technologies able to detect SWIR wavelengths, InGaAs appears as a key technology. Initially developed for optical telecommunications, this material guaranties performances, stability and reliability and is compatible with attractive production capacity. Thanks to high quality material, very low dark current levels can be achieved at ambient temperature. Then uncooled operation can be set up, allowing compact and low power systems. Since the recent transfer of InGaAs imaging activities from III-Vlab, Sofradir provides a framework for the production activity with the manufacturing of high performances products: CACTUS320 SW. The developments towards VGA format with 15μm pixel pitch, lead today to the industrialization of a new product: SNAKE. On one side, the InGaAs detection array presents high performances in terms of dark current and quantum efficiency. On the other side, the low noise ROIC has different additional functionalities. Then this 640x512 @ 15μm sensor appears as well suited to answer the needs of a wide range of applications. In this paper, we will present the Sofradir InGaAs technology, the performances of our last product SNAKE and the perspectives of InGaAs new developments.

  9. Near Infrared (NIR) Imaging Techniques Using Lasers and Nonlinear Crystal Optical Parametric Oscillator/Amplifier (OPO/OPA) Imaging and Transferred Electron (TE) Photocathode Image Intensifiers

    Energy Technology Data Exchange (ETDEWEB)

    YATES,GEORGE J.; MCDONALD,THOMAS E. JR.; BLISS,DAVID E.; CAMERON,STEWART M.; GREIVES,KENNETH H.; ZUTAVERN,FRED J.

    2000-12-20

    Laboratory experiments utilizing different near-infrared (NIR) sensitive imaging techniques for LADAR range gated imaging at eye-safe wavelengths are presented. An OPO/OPA configuration incorporating a nonlinear crystal for wavelength conversion of 1.56 micron probe or broadcast laser light to 807 nm light by utilizing a second pump laser at 532 nm for gating and gain, was evaluated for sensitivity, resolution, and general image quality. These data are presented with similar test results obtained from an image intensifier based upon a transferred electron (TE) photocathode with high quantum efficiency (QE) in the 1-2 micron range, with a P-20 phosphor output screen. Data presented include range-gated imaging performance in a cloud chamber with varying optical attenuation of laser reflectance images.

  10. Gd3+ complex-modified NaLuF4-based upconversion nanophosphors for trimodality imaging of NIR-to-NIR upconversion luminescence, X-Ray computed tomography and magnetic resonance.

    Science.gov (United States)

    Xia, Ao; Chen, Min; Gao, Yuan; Wu, Dongmei; Feng, Wei; Li, Fuyou

    2012-07-01

    Multimodality molecular imaging has recently attracted much attention, because it can take advantage of individual imaging modalities by fusing together information from several molecular imaging techniques. Herein, we report a multifunctional lanthanide-based nanoparticle for near-infrared to near-infrared (NIR-to-NIR) upconversion luminescence (UCL), X-ray computed tomography (CT) and T(1)-enhanced magnetic resonance (MR) trimodality in-vivo imaging. By careful selection of the lanthanide elements, core-shell structured lanthanide-based nanoparticles, NaLuF(4):Yb(3+),Tm(3+)@SiO(2)-GdDTPA nanoparticles (UCNP@SiO(2)-GdDTPA) have been designed and synthesized. We also prove that the application of UCNP@SiO(2)-GdDTPA for NIR-to-NIR UCL, CT and MRI multi-modality in-vivo imaging can be established successfully. In addition, the biological toxicity of UCNP@SiO(2)-GdDTPA is evaluated by the methyl thiazolyl tetrazolium (MTT) assay and histological analysis of viscera sections. Copyright © 2012 Elsevier Ltd. All rights reserved.

  11. Black titania-based theranostic nanoplatform for single NIR laser induced dual-modal imaging-guided PTT/PDT.

    Science.gov (United States)

    Mou, Juan; Lin, Tianquan; Huang, Fuqiang; Chen, Hangrong; Shi, Jianlin

    2016-04-01

    Substantially different from traditional combinatorial-treatment of photothermal therapy (PTT) and photodynamic therapy (PDT) by using multi-component nanocomposite under excitation of separate wavelength, a novel single near infrared (NIR) laser-induced multifunctional theranostic nanoplatform has been rationally and successfully constructed by a single component black titania (B-TiO2-x) for effective imaging-guided cancer therapy for the first time. This multifunctional PEGylated B-TiO2-x shows high dispersity/stability in aqueous solution, excellent hemo/histocompatibility and broad absorption ranging from NIR to ultraviolet (UV). Both in vitro and in vivo results well demonstrated that such a novel multifunctional theranostic nanoplaform could achieve high therapeutic efficacy of simultaneous and synergistic PTT/PDT under the guidance of infrared thermal/photoacoustic (PA) dual-modal imaging, which was triggered by a single NIR laser. This research circumvents the conventional obstacles of using multi-component nanocomposites, UV light and high laser power density. Furthermore, negligible side effects to blood and main tissues could be found in 3 months' investigation, facilitating its potential biomedical application.

  12. Albumin-Mediated Biomineralization of Paramagnetic NIR Ag2S QDs for Tiny Tumor Bimodal Targeted Imaging in Vivo.

    Science.gov (United States)

    Zhang, Jing; Hao, Guangyu; Yao, Chenfei; Yu, Jiani; Wang, Jun; Yang, Weitao; Hu, Chunhong; Zhang, Bingbo

    2016-07-06

    Bimodal imaging has captured increasing interests due to its complementary characteristics of two kinds of imaging modalities. Among the various dual-modal imaging techniques, MR/fluorescence imaging has been widely studied owing to its high 3D resolution and sensitivity. There is, however, still a strong demand to construct biocompatible MR/fluorescence contrast agents with near-infrared (NIR) fluorescent emissions and high relaxivities. In this study, BSA-DTPA(Gd) derived from bovine serum albumin (BSA) as a novel kind of biotemplate is employed for biomineralization of paramagnetic NIR Ag2S quantum dots (denoted as Ag2S@BSA-DTPA(Gd) pQDs). This synthetic strategy is found to be bioinspired, environmentally benign, and straightforward. The obtained Ag2S@BSA-DTPA(Gd) pQDs have fine sizes (ca. 6 nm) and good colloidal stability. They exhibit unabated NIR fluorescent emission (ca. 790 nm) as well as high longitudinal relaxivity (r1 = 12.6 mM(-1) s(-1)) compared to that of commercial Magnevist (r1 = 3.13 mM(-1) s(-1)). In vivo tumor-bearing MR and fluorescence imaging both demonstrate that Ag2S@BSA-DTPA(Gd) pQDs have pronounced tiny tumor targeting capability. In vitro and in vivo toxicity study show Ag2S@BSA-DTPA(Gd) pQDs are biocompatible. Also, biodistribution analysis indicates they can be cleared from body mainly via liver metabolism. This protein-mediated biomineralized Ag2S@BSA-DTPA(Gd) pQDs presents great potential as a novel bimodal imaging contrast agent for tiny tumor diagnosis.

  13. Accuracy of image-guided surgical navigation using near infrared (NIR) optical tracking

    Science.gov (United States)

    Jakubovic, Raphael; Farooq, Hamza; Alarcon, Joseph; Yang, Victor X. D.

    2015-03-01

    Spinal surgery is particularly challenging for surgeons, requiring a high level of expertise and precision without being able to see beyond the surface of the bone. Accurate insertion of pedicle screws is critical considering perforation of the pedicle can result in profound clinical consequences including spinal cord, nerve root, arterial injury, neurological deficits, chronic pain, and/or failed back syndrome. Various navigation systems have been designed to guide pedicle screw fixation. Computed tomography (CT)-based image guided navigation systems increase the accuracy of screw placement allowing for 3- dimensional visualization of the spinal anatomy. Current localization techniques require extensive preparation and introduce spatial deviations. Use of near infrared (NIR) optical tracking allows for realtime navigation of the surgery by utilizing spectral domain multiplexing of light, greatly enhancing the surgeon's situation awareness in the operating room. While the incidence of pedicle screw perforation and complications have been significantly reduced with the introduction of modern navigational technologies, some error exists. Several parameters have been suggested including fiducial localization and registration error, target registration error, and angular deviation. However, many of these techniques quantify error using the pre-operative CT and an intra-operative screenshot without assessing the true screw trajectory. In this study we quantified in-vivo error by comparing the true screw trajectory to the intra-operative trajectory. Pre- and post- operative CT as well as intra-operative screenshots were obtained for a cohort of patients undergoing spinal surgery. We quantified entry point error and angular deviation in the axial and sagittal planes.

  14. Discrimination methods for biological contaminants in fresh-cut lettuce based on VNIR and NIR hyperspectral imaging

    Science.gov (United States)

    Mo, Changyeun; Kim, Giyoung; Kim, Moon S.; Lim, Jongguk; Lee, Seung Hyun; Lee, Hong-Seok; Cho, Byoung-Kwan

    2017-09-01

    The rapid detection of biological contaminants such as worms in fresh-cut vegetables is necessary to improve the efficiency of visual inspections carried out by workers. Multispectral imaging algorithms were developed using visible-near-infrared (VNIR) and near-infrared (NIR) hyperspectral imaging (HSI) techniques to detect worms in fresh-cut lettuce. The optimal wavebands that can detect worms in fresh-cut lettuce were investigated for each type of HSI using one-way ANOVA. Worm-detection imaging algorithms for VNIR and NIR imaging exhibited prediction accuracies of 97.00% (RI547/945) and 100.0% (RI1064/1176, SI1064-1176, RSI-I(1064-1173)/1064, and RSI-II(1064-1176)/(1064+1176)), respectively. The two HSI techniques revealed that spectral images with a pixel size of 1 × 1 mm or 2 × 2 mm had the best classification accuracy for worms. The results demonstrate that hyperspectral reflectance imaging techniques have the potential to detect worms in fresh-cut lettuce. Future research relating to this work will focus on a real-time sorting system for lettuce that can simultaneously detect various defects such as browning, worms, and slugs.

  15. NIR and MR imaging supported hydrogel based delivery system for anti-TNF alpha probiotic therapy of IBD

    Science.gov (United States)

    Janjic, Jelena M.; Berlec, Ales; Bagia, Christina; Liu, Lu S.; Jeric, Irenej; Gach, Michael; Janjic, Bratislav M.; Strukelj, Borut

    2016-03-01

    Current treatment of inflammatory bowel disease (IBD) is largely symptomatic and consists of anti-inflammatory agents, immune-suppressives or antibiotics, whereby local luminal action is preferred to minimize systemic side-effects. Recently, anti-TNFα therapy has shown considerable success and is now being routinely used. Here we present a novel approach of using perfluorocarbon (PFC) nanoemulsion containing hydrogels (nanoemulgels) as imaging supported delivery systems for anti-TNF alpha probiotic delivery in IBD. To further facilitate image-guided therapy a food-grade lactic acid bacterium Lactococcus lactis capable of TNFα-binding was engineered to incorporate infrared fluorescent protein (IRFP). This modified bacteria was then incorporated into novel PFC nanoemulgels. The nanoemulgels presented here are designed to deliver locally anti-TNFα probiotic in the lower colon and rectum and provide dual imaging signature of gel delivery (MRI) across the rectum and lower colon and bacteria release (NIR). NIR imaging data in vitro demonstrates high IRFP expressing and TNFα-binding bacteria loading in the hydrogel and complete release in 3 hours. Stability tests indicate that gels remain stable for at least 14 days showing no significant change in droplet size, zeta potential and pH. Flow cytometry analyses demonstrate the NIRF expressing bacteria L. lactis binds TNFα in vitro upon release from the gels. Magnetic resonance and near-infrared imaging in vitro demonstrates homogeneity of hydrogels and the imaging capacity of the overall formulation.

  16. Real-time near IR (1310 nm) imaging of CO2 laser ablation of enamel.

    Science.gov (United States)

    Darling, Cynthia L; Fried, Daniel

    2008-02-18

    The high-transparency of dental enamel in the near-IR (NIR) can be exploited for real-time imaging of ablation crater formation during drilling with lasers. NIR images were acquired with an InGaAs focal plane array and a NIR zoom microscope during drilling incisions in human enamel samples with a lambda=9.3-microm CO(2) laser operating at repetition rates of 50-300-Hz with and without a water spray. Crack formation, dehydration and thermal changes were observed during ablation. These initial images demonstrate the potential of NIR imaging to monitor laser-ablation events in real-time to provide information about the mechanism of ablation and to evaluate the potential for peripheral thermal and mechanical damage.

  17. On-chip integrated functional near infra-red spectroscopy (fNIRS) photoreceiver for portable brain imaging

    Science.gov (United States)

    Kamrani, Ehsan

    Optical brain imaging using functional near infra-red spectroscopy (fNIRS) offers a direct and noninvasive tool for monitoring of blood oxygenation. fNIRS is a noninvasive, safe, minimally intrusive, and high temporal-resolution technique for real-time and long-term brain imaging. It allows detecting both fast-neuronal and slow-hemodynamic signals. Besides the significant advantages of fNIRS systems, they still suffer from few drawbacks including low spatial-resolution, moderately high-level noise and high-sensitivity to movement. In order to overcome the limitations of currently available non-portable fNIRS systems, we have introduced a new low-power, miniaturized on-chip photodetector front-end intended for portable fNIRS systems. It includes silicon avalanche photodiode (SiAPD), Transimpedance amplifier (TIA), and Quench- Reset circuitry implemented using standard CMOS technologies to operate in both linear and Geiger modes. So it can be applied for both continuous-wave fNIRS (CW-fNIRS) and also single-photon counting applications. Several SiAPDs have been implemented in novel structures and shapes (Rectangular, Octagonal, Dual, Nested, Netted, Quadratic and Hexadecagonal) using different premature edge breakdown prevention techniques. The main characteristics of the SiAPDs are validated and the impact of each parameter and the device simulators (TCAD, COMSOL, etc.) have been studied based on the simulation and measurement results. Proposed techniques exhibit SiAPDs with high avalanche-gain (up to 119), low breakdown-voltage (around 12V) and high photon-detection efficiency (up to 72% in NIR region) in additional to a low dark-count rate (down to 30Hz at 1V excess bias voltage). Three new high gain-bandwidth product (GBW) and low-noise TIAs are introduced and implemented based on distributed-gain concept, logarithmic-amplification and automatic noise-rejection and have been applied in linear-mode of operation. The implemented TIAs offer a power

  18. Highly luminescent and cytocompatible cationic Ag2S NIR-emitting quantum dots for optical imaging and gene transfection

    OpenAIRE

    Duman, Fatma Demir; Hocaoğlu, İbrahim; Hocaoglu, Ibrahim; Öztürk, Deniz Gülfem; Ozturk, Deniz Gulfem; Gözüaçık, Devrim; Gozuacik, Devrim; Kiraz, Alper; Yağcı Acar, Havva; Yagci Acar, Havva

    2015-01-01

    Nanoscale PAPER Cite this: Nanoscale, 2015, 7, 11352 Received 12th January 2015, Accepted 23rd May 2015 DOI: 10.1039/c5nr00189g www.rsc.org/nanoscale Highly luminescent and cytocompatible cationic Ag2S NIR-emitting quantum dots for optical imaging and gene transfection† Fatma Demir Duman,a Ibrahim Hocaoglu,a Deniz Gulfem Ozturk,b Devrim Gozuacik,b Alper Kiraza,c and Havva Yagci Acar*a,d,e The development of non-toxic theranostic nanoparticles capable of del...

  19. NIR fluorescent image-based evaluation of gastric tube perfusion after esophagectomy in preclinical model (Conference Presentation)

    Science.gov (United States)

    Kim, Minji; Quan, Yuhua; Han, Kook Nam; Choi, Byeong Hyun; Choi, Yeonho; Kim, Hyun Koo; Kim, Beop-Min

    2016-03-01

    This study was to evaluate the feasibility of near infrared (NIR) fluorescent images as a tool for evaluating the perfusion of the gastric tube after esophagectomy. In addition, we investigated the time required to acquire enough signal to confirm the presence of ischemia in gastric tube after injection of indocyanine green (ICG) through peripheral versus and central venous route. 4 porcine underwent esophagogastrostomy and their right gastric arteries were ligated to mimic ischemic condition of gastric tube. ICG (0.6mg/kg) was intravenously injected and the fluorescence signal-to-background ratios (SBR) were measured by using the custom-built intraoperative color and fluorescence imaging system (ICFIS). We evaluated perfusion of gastric tubes by comparing their SBR with esophageal SBR. In ischemic models, SBR of esophagus was higher than that of gastric tube (2.8+/-0.54 vs. 1.7+/-0.37, pperfusion in few minutes after releasing the ligation of right gastric artery. In addition, in comparison study according to the injection route of ICG, The time to acquire signal stabilization was faster in central than in peripheral route (119 +/- 65.1 seconds in central route vs. 295+/-130.4 in peripheral route, p<0.05). NIR fluorescent images could provide the real-time information if there was ischemia or not in gastric tube during operation. And, central injection of ICG might give that information faster than peripheral route.

  20. In vitro near-infrared imaging of occlusal dental caries using a germanium-enhanced CMOS camera

    Science.gov (United States)

    Lee, Chulsung; Darling, Cynthia L.; Fried, Daniel

    2010-02-01

    The high transparency of dental enamel in the near-infrared (NIR) at 1310-nm can be exploited for imaging dental caries without the use of ionizing radiation. The objective of this study was to determine whether the lesion contrast derived from NIR transillumination can be used to estimate lesion severity. Another aim was to compare the performance of a new Ge enhanced complementary metal-oxide-semiconductor (CMOS) based NIR imaging camera with the InGaAs focal plane array (FPA). Extracted human teeth (n=52) with natural occlusal caries were imaged with both cameras at 1310-nm and the image contrast between sound and carious regions was calculated. After NIR imaging, teeth were sectioned and examined using more established methods, namely polarized light microscopy (PLM) and transverse microradiography (TMR) to calculate lesion severity. Lesions were then classified into 4 categories according to the lesion severity. Lesion contrast increased significantly with lesion severity for both cameras (pequipped with the larger array and smaller pixels yielded higher contrast values compared with the smaller InGaAs FPA (p<0.01). Results demonstrate that NIR lesion contrast can be used to estimate lesion severity.

  1. Evaluation of combined near-IR spectroscopic (NIRS)-IVUS imaging as a means to detect lipid-rich plaque burden in human coronary autopsy specimens

    Science.gov (United States)

    Su, Jimmy L.; Grainger, Stephanie J.; Greiner, Cherry A.; Hendricks, Michael J.; Goode, Meghan M.; Saybolt, Matthew D.; Wilensky, Robert L.; Madden, Sean P.; Muller, James E.

    2016-02-01

    Intracoronary near-infrared spectroscopy (NIRS) can identify lipid in the coronary arteries, but lacks depth resolution. A novel catheter is currently in clinical use that combines NIRS with intravascular ultrasound (IVUS), which provides depth-resolved structural information via the IVUS modality. A measure designated as lipid-rich plaque burden (LRPB) has been proposed as a means to interpret the combined acoustic and optical information of NIRS-IVUS. LRPB is defined as the area created by the intersection of the NIRS lipid-rich arc with the corresponding IVUS-measured plaque burden. We determined the correlation in human coronary autopsy specimens between LRPB, a measure of lipid presence and extent available via intravascular imaging in patients, and the area of lipid-rich plaque as determined by the gold-standard of histology. Fifteen artery segments from 8 human autopsy hearts were imaged with the NIRS-IVUS system (TVC Imaging System, Infraredx Inc., Burlington, MA). Arteries were imaged in a specialty fixture that assured accurate co-registration between imaging and histology. The arteries were then fixed and divided into 2 mm blocks for histological staining. Pathological contouring of lipid-rich areas was performed on the stained thin sections for 54 lipid-rich blocks. Computation of LRPB was performed on transverse NIRS-IVUS frames corresponding to the histologic sections. The quantified LRPB was frequently higher than the lipid-rich plaque area determined by histology, because the region denoted by the EEL and lumen within the NIRS lipid-rich arc is not entirely comprised of lipid. Overall, a moderate to strong correlation (R = 0.73) was found between LRPB determined by NIRS-IVUS imaging and the lipid-rich plaque area determined by histology. LRPB, which can be measured in patients with NIRS-IVUS imaging, corresponds to the amount of lipid-rich plaque in a coronary artery. LRPB should be evaluated in prospective clinical trials for its ability to

  2. Multimodal neuroimaging of prefrontal cortex (dys)function: EEG, fNIRS, fNIRS-fMRI and Imaging Genetics approaches

    OpenAIRE

    Heinzel, Sebastian

    2013-01-01

    The present cumulative dissertation comprises three neuroimaging studies using different techniques, functional tasks and experimental variables of diverse nature to investigate human prefrontal cortex (PFC) (dys)function as well as methodological aspects of functional near-infrared spectroscopy (fNIRS). (1) Both dopamine (DA) availability (“inverted U-model”) and excitatory versus inhibitory DA receptor stimulation (“dual-state theory”) have been linked to PFC processing and cognitive contro...

  3. Application of IR and NIR fiber optic imaging in thermographic and spectroscopic diagnosis of atherosclerotic vulnerable plaques: preliminary experience

    Science.gov (United States)

    Naghavi, Morteza; Khan, Tania; Gu, Bujin; Soller, Babs R.; Melling, Peter; Asif, Mohammed; Gul, Khawar; Madjid, Mohammad; Casscells, S. W.; Willerson, James T.

    2000-12-01

    Despite major advances in cardiovascular science and technology during the past three decades, approximately half of all myocardial infarctions and sudden deaths occur unexpectedly. It is widely accepted that coronary atherosclerotic plaques and thrombotic complications resulting from their rupture or erosion are the underlying causes of this major health problem. The majority of these vulnerable plaques exhibit active inflammation, a large necrotic lipid core, a thin fibrous cap, and confer a stenosis of less than 70%. These lesions are not detectable by stress testing or coronary angiography. Our group is exploring the possibility of a functional classification based on physiological variables such as plaque temperature, pH, oxygen consumption, lactate production etc. We have shown that heat accurately locates the inflamed plaques. We also demonstrated human atherosclerotic plaques are heterogeneous with regard to pH and hot plaques and are more likely to be acidic. To develop a nonsurgical method for locating the inflamed plaques, we are developing both IR fiber optic imaging and NIR spectroscopic systems in our laboratory to detect hot and acidic plaque in atherosclerotic arterial walls. Our findings introduce the possibility of an isolated/combined IR and NIR fiber optic catheter that can bring new insight into functional assessment of atherosclerotic plaque and thereby detection of active and inflamed lesions responsible for heart attacks and strokes.

  4. A NIR fluorescent probe for the rapid detection of Hg2+ in living cells and in vivo mice imaging

    Science.gov (United States)

    Wang, Jiaoliang; Long, Liping; Xia, Li; Fang, Fang

    2017-06-01

    A near-infrared fluorescent probe NIR-Hg, for the detection of Hg2+ ion, has been synthesized directly by condensing Changsha dye with 4-Phenyl-3-thiosemicarbazide and the structure has fully characterized by 1HNMR, 13CNMR, and ESI-MS. The probe has been designed on the basis of the reaction that Hg2+ ion promotes thiosemicarbazide to oxazole in aqueous media and had been induced to produce turn-on fluorescence via an irreversible spirolactam ring-opening process. The probe NIR-Hg has exhibited fast response (1 min), high sensitivity with 44-fold fluorescence intensity enhancement under six equivalent amounts of Hg2+ added, high selectivity over other related metal ions and a low detection limit of 5.8 × 10-8 M in the phosphate buffer. The linear response range covers the concentration of Hg2+ from 5 × 10-7 to 5 × 10-6 M. In addition, the probe has good cell-membrane permeability, which is suitable for fluorescence imaging for Hg2+ in living cells and in vivo mice.

  5. Ability of combined Near-Infrared Spectroscopy-Intravascular Ultrasound (NIRS-IVUS) imaging to detect lipid core plaques and estimate cap thickness in human autopsy coronary arteries

    Science.gov (United States)

    Grainger, S. J.; Su, J. L.; Greiner, C. A.; Saybolt, M. D.; Wilensky, R. L.; Raichlen, J. S.; Madden, S. P.; Muller, J. E.

    2016-03-01

    The ability to determine plaque cap thickness during catheterization is thought to be of clinical importance for plaque vulnerability assessment. While methods to compositionally assess cap integrity are in development, a method utilizing currently available tools to measure cap thickness is highly desirable. NIRS-IVUS is a commercially available dual imaging method in current clinical use that may provide cap thickness information to the skilled reader; however, this is as yet unproven. Ten autopsy hearts (n=15 arterial segments) were scanned with the multimodality NIRS-IVUS catheter (TVC Imaging System, Infraredx, Inc.) to identify lipid core plaques (LCPs). Skilled readers made predictions of cap thickness over regions of chemogram LCP, using NIRS-IVUS. Artery segments were perfusion fixed and cut into 2 mm serial blocks. Thin sections stained with Movat's pentachrome were analyzed for cap thickness at LCP regions. Block level predictions were compared to histology, as classified by a blinded pathologist. Within 15 arterial segments, 117 chemogram blocks were found by NIRS to contain LCP. Utilizing NIRSIVUS, chemogram blocks were divided into 4 categories: thin capped fibroatheromas (TCFA), thick capped fibroatheromas (ThCFA), pathological intimal thickening (PIT)/lipid pool (no defined cap), and calcified/unable to determine cap thickness. Sensitivities/specificities for thin cap fibroatheromas, thick cap fibroatheromas, and PIT/lipid pools were 0.54/0.99, 0.68/0.88, and 0.80/0.97, respectively. The overall accuracy rate was 70.1% (including 22 blocks unable to predict, p = 0.075). In the absence of calcium, NIRS-IVUS imaging provided predictions of cap thickness over LCP with moderate accuracy. The ability of this multimodality imaging method to identify vulnerable coronary plaques requires further assessment in both larger autopsy studies, and clinical studies in patients undergoing NIRS-IVUS imaging.

  6. Transillumination and reflectance probes for in vivo near-IR imaging of dental caries

    Science.gov (United States)

    Simon, Jacob C.; Lucas, Seth A.; Staninec, Michal; Tom, Henry; Chan, Kenneth H.; Darling, Cynthia L.; Fried, Daniel

    2014-02-01

    Previous studies have demonstrated the utility of near infrared (NIR) imaging for caries detection employing transillumination and reflectance imaging geometries. Three intra-oral NIR imaging probes were fabricated for the acquisition of in vivo, real time videos using a high definition InGaAs SWIR camera and near-IR broadband light sources. Two transillumination probes provide occlusal and interproximal images using 1300-nm light where water absorption is low and enamel manifests the highest transparency. A third reflectance probe utilizes cross polarization and operates at >1500-nm, where water absorption is higher which reduces the reflectivity of sound tissues, significantly increasing lesion contrast. These probes are being used in an ongoing clinical study to assess the diagnostic performance of NIR imaging for the detection of caries lesions in teeth scheduled for extraction for orthodontic reasons.

  7. On children's dyslexia with NIRS

    Science.gov (United States)

    Gan, Zhuo; Li, Chengjun; Gong, Hui; Luo, Qingming; Yao, Bin; Song, Ranran; Wu, Hanrong

    2003-12-01

    Developmental dyslexia is a kind of prevalent psychologic disease. Some functional imaging technologies, such as FMRI and PET, have been used to study the brain activities of dyslexics. NIRS is a kind of novel technology which is more and more widely being used for study of the cognitive psychology. However, there aren"t reports about the dyslexic research using NIRS to be found until now. This paper introduces a NIRS system of four measuring channels. Brain activities of dyslexic subjects and normal subjects during reading task were studied with the NIRS system. Two groups of subjects, the group of dyslexia and the group of normal, were appointed to perform two reading tasks. At the same time, their cortical activities were measured with the NIRS system. This experimental result indicates that the brain activities of the dyslexic group were significantly higher than the control group in BA 48 and that NIRS can be used for the study of human brain activity.

  8. Improved classification and visualization of healthy and pathological hard dental tissues by modeling specular reflections in NIR hyperspectral images

    Science.gov (United States)

    Usenik, Peter; Bürmen, Miran; Fidler, Aleš; Pernuš, Franjo; Likar, Boštjan

    2012-03-01

    Despite major improvements in dental healthcare and technology, dental caries remains one of the most prevalent chronic diseases of modern society. The initial stages of dental caries are characterized by demineralization of enamel crystals, commonly known as white spots, which are difficult to diagnose. Near-infrared (NIR) hyperspectral imaging is a new promising technique for early detection of demineralization which can classify healthy and pathological dental tissues. However, due to non-ideal illumination of the tooth surface the hyperspectral images can exhibit specular reflections, in particular around the edges and the ridges of the teeth. These reflections significantly affect the performance of automated classification and visualization methods. Cross polarized imaging setup can effectively remove the specular reflections, however is due to the complexity and other imaging setup limitations not always possible. In this paper, we propose an alternative approach based on modeling the specular reflections of hard dental tissues, which significantly improves the classification accuracy in the presence of specular reflections. The method was evaluated on five extracted human teeth with corresponding gold standard for 6 different healthy and pathological hard dental tissues including enamel, dentin, calculus, dentin caries, enamel caries and demineralized regions. Principal component analysis (PCA) was used for multivariate local modeling of healthy and pathological dental tissues. The classification was performed by employing multiple discriminant analysis. Based on the obtained results we believe the proposed method can be considered as an effective alternative to the complex cross polarized imaging setups.

  9. Near-infrared chemical imaging (NIR-CI) of 3D printed pharmaceuticals

    DEFF Research Database (Denmark)

    Khorasani, Milad; Edinger, Magnus; Raijada, Dhara

    2016-01-01

    Hot-melt extrusion and 3D printing are enabling manufacturing approaches for patient-centred medicinal products. Hot-melt extrusion is a flexible and continuously operating technique which is a crucial part of a typical processing cycle of printed medicines. In this work we use hot-melt extrusion...... for manufacturing of medicinal films containing indomethacin (IND) and polycaprolactone (PCL), extruded strands with nitrofurantoin monohydrate (NFMH) and poly (ethylene oxide) (PEO), and feedstocks for 3D printed dosage forms with nitrofurantoin anhydrate (NFAH), hydroxyapatite (HA) and poly (lactic acid) (PLA...... and nitrofurantoin). Similar results were achieved in the 3D printed solid dosage forms produced from the extruded feedstocks. The results presented in this work clearly demonstrate that NIR-CI in combination with MCR-ALS can be used for chemical mapping of both active compound and excipients, as well...

  10. Visualization and understanding of the granulation liquid mixing and distribution during continuous twin screw granulation using NIR chemical imaging.

    Science.gov (United States)

    Vercruysse, Jurgen; Toiviainen, Maunu; Fonteyne, Margot; Helkimo, Niko; Ketolainen, Jarkko; Juuti, Mikko; Delaet, Urbain; Van Assche, Ivo; Remon, Jean Paul; Vervaet, Chris; De Beer, Thomas

    2014-04-01

    Over the last decade, there has been increased interest in the application of twin screw granulation as a continuous wet granulation technique for pharmaceutical drug formulations. However, the mixing of granulation liquid and powder material during the short residence time inside the screw chamber and the atypical particle size distribution (PSD) of granules produced by twin screw granulation is not yet fully understood. Therefore, this study aims at visualizing the granulation liquid mixing and distribution during continuous twin screw granulation using NIR chemical imaging. In first instance, the residence time of material inside the barrel was investigated as function of screw speed and moisture content followed by the visualization of the granulation liquid distribution as function of different formulation and process parameters (liquid feed rate, liquid addition method, screw configuration, moisture content and barrel filling degree). The link between moisture uniformity and granule size distributions was also studied. For residence time analysis, increased screw speed and lower moisture content resulted to a shorter mean residence time and narrower residence time distribution. Besides, the distribution of granulation liquid was more homogenous at higher moisture content and with more kneading zones on the granulator screws. After optimization of the screw configuration, a two-level full factorial experimental design was performed to evaluate the influence of moisture content, screw speed and powder feed rate on the mixing efficiency of the powder and liquid phase. From these results, it was concluded that only increasing the moisture content significantly improved the granulation liquid distribution. This study demonstrates that NIR chemical imaging is a fast and adequate measurement tool for allowing process visualization and hence for providing better process understanding of a continuous twin screw granulation system.

  11. Integration of Point Clouds and Images Acquired from a Low-Cost NIR Camera Sensor for Cultural Heritage Purposes

    Science.gov (United States)

    Kedzierski, M.; Walczykowski, P.; Wojtkowska, M.; Fryskowska, A.

    2017-08-01

    Terrestrial Laser Scanning is currently one of the most common techniques for modelling and documenting structures of cultural heritage. However, only geometric information on its own, without the addition of imagery data is insufficient when formulating a precise statement about the status of studies structure, for feature extraction or indicating the sites to be restored. Therefore, the Authors propose the integration of spatial data from terrestrial laser scanning with imaging data from low-cost cameras. The use of images from low-cost cameras makes it possible to limit the costs needed to complete such a study, and thus, increasing the possibility of intensifying the frequency of photographing and monitoring of the given structure. As a result, the analysed cultural heritage structures can be monitored more closely and in more detail, meaning that the technical documentation concerning this structure is also more precise. To supplement the laser scanning information, the Authors propose using both images taken both in the near-infrared range and in the visible range. This choice is motivated by the fact that not all important features of historical structures are always visible RGB, but they can be identified in NIR imagery, which, with the additional merging with a three-dimensional point cloud, gives full spatial information about the cultural heritage structure in question. The Authors proposed an algorithm that automates the process of integrating NIR images with a point cloud using parameters, which had been calculated during the transformation of RGB images. A number of conditions affecting the accuracy of the texturing had been studies, in particular, the impact of the geometry of the distribution of adjustment points and their amount on the accuracy of the integration process, the correlation between the intensity value and the error on specific points using images in different ranges of the electromagnetic spectrum and the selection of the optimal

  12. INTEGRATION OF POINT CLOUDS AND IMAGES ACQUIRED FROM A LOW-COST NIR CAMERA SENSOR FOR CULTURAL HERITAGE PURPOSES

    Directory of Open Access Journals (Sweden)

    M. Kedzierski

    2017-08-01

    Full Text Available Terrestrial Laser Scanning is currently one of the most common techniques for modelling and documenting structures of cultural heritage. However, only geometric information on its own, without the addition of imagery data is insufficient when formulating a precise statement about the status of studies structure, for feature extraction or indicating the sites to be restored. Therefore, the Authors propose the integration of spatial data from terrestrial laser scanning with imaging data from low-cost cameras. The use of images from low-cost cameras makes it possible to limit the costs needed to complete such a study, and thus, increasing the possibility of intensifying the frequency of photographing and monitoring of the given structure. As a result, the analysed cultural heritage structures can be monitored more closely and in more detail, meaning that the technical documentation concerning this structure is also more precise. To supplement the laser scanning information, the Authors propose using both images taken both in the near-infrared range and in the visible range. This choice is motivated by the fact that not all important features of historical structures are always visible RGB, but they can be identified in NIR imagery, which, with the additional merging with a three-dimensional point cloud, gives full spatial information about the cultural heritage structure in question. The Authors proposed an algorithm that automates the process of integrating NIR images with a point cloud using parameters, which had been calculated during the transformation of RGB images. A number of conditions affecting the accuracy of the texturing had been studies, in particular, the impact of the geometry of the distribution of adjustment points and their amount on the accuracy of the integration process, the correlation between the intensity value and the error on specific points using images in different ranges of the electromagnetic spectrum and the selection

  13. Computational Pipeline for NIRS-EEG Joint Imaging of tDCS-Evoked Cerebral Responses—An Application in Ischemic Stroke

    Science.gov (United States)

    Guhathakurta, Debarpan; Dutta, Anirban

    2016-01-01

    Transcranial direct current stimulation (tDCS) modulates cortical neural activity and hemodynamics. Electrophysiological methods (electroencephalography-EEG) measure neural activity while optical methods (near-infrared spectroscopy-NIRS) measure hemodynamics coupled through neurovascular coupling (NVC). Assessment of NVC requires development of NIRS-EEG joint-imaging sensor montages that are sensitive to the tDCS affected brain areas. In this methods paper, we present a software pipeline incorporating freely available software tools that can be used to target vascular territories with tDCS and develop a NIRS-EEG probe for joint imaging of tDCS-evoked responses. We apply this software pipeline to target primarily the outer convexity of the brain territory (superficial divisions) of the middle cerebral artery (MCA). We then present a computational method based on Empirical Mode Decomposition of NIRS and EEG time series into a set of intrinsic mode functions (IMFs), and then perform a cross-correlation analysis on those IMFs from NIRS and EEG signals to model NVC at the lesional and contralesional hemispheres of an ischemic stroke patient. For the contralesional hemisphere, a strong positive correlation between IMFs of regional cerebral hemoglobin oxygen saturation and the log-transformed mean-power time-series of IMFs for EEG with a lag of about −15 s was found after a cumulative 550 s stimulation of anodal tDCS. It is postulated that system identification, for example using a continuous-time autoregressive model, of this coupling relation under tDCS perturbation may provide spatiotemporal discriminatory features for the identification of ischemia. Furthermore, portable NIRS-EEG joint imaging can be incorporated into brain computer interfaces to monitor tDCS-facilitated neurointervention as well as cortical reorganization. PMID:27378836

  14. Wide-band IR imaging in the NIR-MIR-FIR regions for in situ analysis of frescoes

    Science.gov (United States)

    Daffara, C.; Pezzati, L.; Ambrosini, D.; Paoletti, D.; Di Biase, R.; Mariotti, P. I.; Frosinini, C.

    2011-06-01

    Imaging methods offer several advantages in the field of conservation allowing to perform non-invasive inspection of works of art. In particular, non-invasive techniques based on imaging in different infrared (IR) regions are widely used for the investigation of paintings. Using radiation beyond the visible range, different characteristics of the inspected artwork may be revealed according to the bandwidth acquired. In this paper we present the recent results of a joint project among the two research institutes DIMEG and CNR-INO, and the restoration facility Opificio delle Pietre Dure, concerning the wide-band integration of IR imaging techniques, in the spectral ranges NIR 0.8-2.5 μm, MIR 3-5 μm, and FIR 8-12 μm, for in situ analysis of artworks. A joint, multi-mode use of reflection and thermal bands is proposed for the diagnostics of mural paintings, and it is demonstrated to be an effective tool in inspecting the layered structure. High resolution IR reflectography and, to a greater extent, IR imaging in the 3-5 μm band, are effectively used to characterize the superficial layer of the fresco and to analyze the stratigraphy of different pictorial layers. IR thermography in the 8-12 μm band is used to characterize the support deep structure. The integration of all the data provides a multi- layered and multi-spectral representation of the fresco that yields a comprehensive analysis.

  15. A novel CMOS-compatible, monolithically integrated line-scan hyperspectral imager covering the VIS-NIR range

    Science.gov (United States)

    Gonzalez, Pilar; Tack, Klaas; Geelen, Bert; Masschelein, Bart; Charle, Wouter; Vereecke, Bart; Lambrechts, Andy

    2016-05-01

    Imec has developed a process for the monolithic integration of optical filters on top of CMOS image sensors, leading to compact, cost-efficient and faster hyperspectral cameras. Different prototype sensors are available, most notably a 600- 1000 nm line-scan imager, and two mosaic sensors: a 4x4 VIS (470-620 nm range) and a 5x5 VNIR (600-1000 nm). In response to the users' demand for a single sensor able to cover both the VIS and NIR ranges, further developments have been made to enable more demanding applications. As a result, this paper presents the latest addition to imec's family of monolithically-integrated hyperspectral sensors: a line scan sensor covering the range 470-900 nm. This new prototype sensor can acquire hyperspectral image cubes of 2048 pixels over 192 bands (128 bands for the 600- 900 nm range, and 64 bands for the 470-620 nm range) at 340 cubes per second for normal machine vision illumination levels.

  16. Near-infrared chemical imaging (NIR-CI) as a process monitoring solution for a production line of roll compaction and tableting

    DEFF Research Database (Denmark)

    Khorasani, Milad Rouhi; Amigo Rubio, Jose Manuel; Sun, Changquan Calvin

    2015-01-01

    In the present study the application of near-infrared chemical imaging (NIR-CI) supported by chemometric modeling as non-destructive tool for monitoring and assessing the roller compaction and tableting processes was investigated. Based on preliminary risk-assessment, discussion with experts and ...... and granule size was established, respectively. These approaches are considered to have a potentially large impact on quality monitoring and control of continuously operating manufacturing lines, such as roller compaction and tableting processes.......In the present study the application of near-infrared chemical imaging (NIR-CI) supported by chemometric modeling as non-destructive tool for monitoring and assessing the roller compaction and tableting processes was investigated. Based on preliminary risk-assessment, discussion with experts...... settings were carried out which revealed intermediates (ribbons, granules) and final products (tablets) with different properties. Principal component analysis (PCA) based model of NIR images was applied to map the ribbon porosity distribution. The ribbon porosity distribution gained from the PCA based NIR...

  17. Near-infrared chemical imaging (NIR-CI) on roll compacted ribbons and tablets--multivariate mapping of physical and chemical properties.

    Science.gov (United States)

    Souihi, Nabil; Nilsson, David; Josefson, Mats; Trygg, Johan

    2015-04-10

    Near-infrared chemical imaging (NIR-CI) is an attractive technique within the pharmaceutical industry, where tools are continuously in demand to assess the quality of the intermediate and final products. The present paper demonstrates how NIR-CI in combination with multivariate methods was utilized to spatially map physical properties and content of roll compacted ribbons and tablets. Additionally, extracted textural parameters from tablet images were correlated to the design parameters of the roll compaction process as well as to the physical properties of the granules. The results established the use of NIR-CI as a complementary nondestructive tool to determine the ribbon density and map the density distribution across the width and along the length of the ribbons. For the tablets, the compaction pressure developed during compression increased with the lateral distance from the center. Therefore, NIR-CI can be an effective tool to provide information about the spatial distribution of the compaction pressures on the surface of the tablet. Moreover, low roll compaction roll force correlated to a heterogeneous type of texture in the API chemical image. Overall, texture analysis of the tablets enabled efficient investigation of the spatial variation and could be used to advance process understanding. Finally, orthogonal projections to latent structures (O2PLS) model facilitated the understanding of the interrelationships between textural features, design parameters and physical properties data by separately joint and unique variations.

  18. A feasibility study of NIR fluorescent image-guided surgery in head and neck cancer based on the assessment of optimum surgical time as revealed through dynamic imaging

    Directory of Open Access Journals (Sweden)

    Yokoyama J

    2013-04-01

    Full Text Available Junkichi Yokoyama,* Mitsuhisa Fujimaki,* Shinichi Ohba, Takashi Anzai, Ryota Yoshii, Shin Ito, Masataka Kojima, Katsuhisa IkedaDepartment of Otolaryngology-Head and Neck Surgery, Juntendo University School of Medicine, Tokyo, Japan *These authors contributed equally to this study Background: In order to minimize surgical stress and preserve organs, endoscopic or robotic surgery is often performed when conducting head and neck surgery. However, it is impossible to physically touch tumors or to observe diffusely invaded deep organs through the procedure of endoscopic or robotic surgery. In order to visualize and safely resect tumors even in these cases, we propose using an indocyanine green (ICG fluorescence method for navigation surgery in head and neck cancer. Objective: To determine the optimum surgical time for tumor resection after the administration of ICG based on the investigation of dynamic ICG fluorescence imaging. Methods: Nine patients underwent dynamic ICG fluorescence imaging for 360 minutes, assessing tumor visibility at 10, 30, 60, 120, 180, and 360 minutes. All cases were scored according to near-infrared (NIR fluorescence imaging visibility scored from 0 to 5. Results: Dynamic NIR fluorescence imaging under the HyperEye Medical System indicated that the greatest contrast in fluorescent images between tumor and normal tissue could be observed from 30 minutes to 1 hour after the administration of ICG. The optimum surgical time was determined to be between 30 minutes to 2 hours after ICG injection. These findings are particularly useful for detection and safe resection of tumors invading the parapharyngeal space. Conclusion: ICG fluorescence imaging is effective for the detection of head and neck cancer. Preliminary findings suggest that the optimum timing for surgery is from 30 minutes to 2 hours after the ICG injection. Keywords: indocyanine green (ICG, navigation surgery, robotic surgery, endoscopic surgery, minimally invasive

  19. Detection of melamine in milk powders based on NIR hyperspectral imaging and spectral similarity analyses

    Science.gov (United States)

    Melamine (2,4,6-triamino-1,3,5-triazine) contamination of food has become an urgent and broadly recognized topic as a result of several food safety scares in the past five years. Hyperspectral imaging techniques that combine the advantages of spectroscopy and imaging have been widely applied for a v...

  20. Label-free NIR reflectance imaging as a complimentary tool for two-photon fluorescence microscopy: multimodal investigation of stroke (Conference Presentation)

    Science.gov (United States)

    Allegra Mascaro, Anna Letizia; Costantini, Irene; Margoni, Emilia; Iannello, Giulio; Bria, Alessandro; Sacconi, Leonardo; Pavone, Francesco S.

    2016-03-01

    Two-photon imaging combined with targeted fluorescent indicators is extensively used for visualizing critical features of brain functionality and structural plasticity. Back-scattered photons from the NIR laser provide complimentary information without introducing any exogenous labelling. Here, we describe a versatile approach that, by collecting the reflected NIR light, provides structural details on the myelinated axons and blood vessels in the brain, both in fixed samples and in live animals. Indeed, by combining NIR reflectance and two-photon imaging of a slice of hippocampus from Thy1-GFPm mice, we show the presence of randomly oriented axons intermingled with sparsely fluorescent neuronal processes. The back-scattered photons guide the contextualization of the fluorescence structure within brain atlas thanks to the recognition of characteristic hippocampal structures. Label-free detection of axonal elongations over the layer 2/3 of mouse cortex under a cranial window was also possible in live brain. Finally, blood flow could be measured in vivo, thus validating label free NIR reflectance as a tool for monitoring hemodynamic fluctuations. The prospective versatility of this label-free technique complimentary to two-photon fluorescence microscopy is demonstrated in a mouse model of photothrombotic stroke in which the axonal degeneration and blood flow remodeling can be investigated simultaneously.

  1. Modular Integration of Upconverting Nanocrystal-Dendrimer Composites for Folate Receptor-Specific NIR Imaging and Light-Triggered Drug Release.

    Science.gov (United States)

    Wong, Pamela T; Chen, Dexin; Tang, Shengzhuang; Yanik, Sean; Payne, Michael; Mukherjee, Jhindan; Coulter, Alexa; Tang, Kenny; Tao, Ke; Sun, Kang; Baker, James R; Choi, Seok Ki

    2015-12-02

    Upconversion nanocrystals (UCNs) display near-infrared (NIR)-responsive photoluminescent properties for NIR imaging and drug delivery. The development of effective strategies for UCN integration with other complementary nanostructures for targeting and drug conjugation is highly desirable. This study reports on a core/shell-based theranostic system designed by UCN integration with a folate (FA)-conjugated dendrimer for tumor targeting and with photocaged doxorubicin as a cytotoxic agent. Two types of UCNs (NaYF4:Yb/Er (or Yb/Tm); diameter = ≈50 to 54 nm) are described, each displaying distinct emission properties upon NIR (980 nm) excitation. The UCNs are surface modified through covalent attachment of photocaged doxorubicin (ONB-Dox) and a multivalent FA-conjugated polyamidoamine (PAMAM) dendrimer G5(FA)6 to prepare UCN@(ONB-Dox)(G5FA). Surface plasmon resonance experiments performed with G5(FA)6 dendrimer alone show nanomolar binding avidity (KD = 5.9 × 10(-9) M) to the folate binding protein. This dendrimer binding corresponds with selective binding and uptake of UCN@(ONB-Dox)(G5FA) by FAR-positive KB carcinoma cells in vitro. Furthermore, UCN@(ONB-Dox)(G5FA) treatment of FAR(+) KB cells inhibits cell growth in a light dependent manner. These results validate the utility of modularly integrated UCN-dendrimer nanocomposites for cell type specific NIR imaging and light-controlled drug release, thus serving as a new theranostic system.

  2. On the use of asymmetric PSF on NIR images of crowded stellar fields

    CERN Document Server

    Fiorentino, Giuliana; Iannicola, Giacinto; Bono, Giuseppe; Monelli, Matteo; Testa, Vincenzo; Arcidiacono, Carmelo; Faccini, Marco; Gilmozzi, Roberto; Xompero, Marco; Briguglio, Runa

    2014-01-01

    We present data collected using the camera PISCES coupled with the Firt Light Adaptive Optics (FLAO) mounted at the Large Binocular Telescope (LBT). The images were collected using two natural guide stars with an apparent magnitude of R<13 mag. During these observations the seeing was on average ~0.9". The AO performed very well: the images display a mean FWHM of 0.05 arcsec and of 0.06 arcsec in the J- and in the Ks-band, respectively. The Strehl ratio on the quoted images reaches 13-30% (J) and 50-65% (Ks), in the off and in the central pointings respectively. On the basis of this sample we have reached a J-band limiting magnitude of ~22.5 mag and the deepest Ks-band limiting magnitude ever obtained in a crowded stellar field: Ks~23 mag. J-band images display a complex change in the shape of the PSF when moving at larger radial distances from the natural guide star. In particular, the stellar images become more elongated in approaching the corners of the J-band images whereas the Ks-band images are more ...

  3. Infrared to visible image up-conversion using optically addressed spatial light modulator utilizing liquid crystal and InGaAs photodiodes

    Energy Technology Data Exchange (ETDEWEB)

    Solodar, A., E-mail: asisolodar@gmail.com; Arun Kumar, T.; Sarusi, G.; Abdulhalim, I. [Department of Electro-Optics Engineering and The Ilse Katz Institute for Nanoscale Science and Technology, Ben Gurion University of the Negev, Beer Sheva 84105 (Israel)

    2016-01-11

    Combination of InGaAs/InP heterojunction photodetector with nematic liquid crystal (LC) as the electro-optic modulating material for optically addressed spatial light modulator for short wavelength infra-red (SWIR) to visible light image conversion was designed, fabricated, and tested. The photodetector layer is composed of 640 × 512 photodiodes array based on heterojunction InP/InGaAs having 15 μm pitch on InP substrate and with backside illumination architecture. The photodiodes exhibit extremely low, dark current at room temperature, with optimum photo-response in the SWIR region. The photocurrent generated in the heterojunction, due to the SWIR photons absorption, is drifted to the surface of the InP, thus modulating the electric field distribution which modifies the orientation of the LC molecules. This device can be attractive for SWIR to visible image upconversion, such as for uncooled night vision goggles under low ambient light conditions.

  4. Laser illumination and EO systems for covert surveillance from NIR to SWIR and beyond

    Science.gov (United States)

    Dvinelis, Edgaras; Žukauskas, Tomas; Kaušylas, Mindaugas; Vizbaras, Augustinas; Vizbaras, Kristijonas; Vizbaras, Dominykas

    2016-10-01

    One of the most important factor of success in battlefield is the ability to remain undetected by the opposing forces while also having an ability to detect all possible threats. Illumination and pointing systems working in NIR and SWIR bands are presented. Wavelengths up to 1100 nm can be registered by newest generation image intensifier tubes, CCD and EMCCD sensors. Image intensifier tubes of generation III or older are only limited up to wavelength of 900 nm [1]. Longer wavelengths of 1550 nm and 1625 nm are designed to be used with SWIR electro-optical systems and they cannot be detected by any standard night vision system. Long range SWIR illuminators and pointers have beam divergences down to 1 mrad and optical powers up to 1.5 W. Due to lower atmospheric scattering SWIR illuminators and pointers can be used at extremely long distances up to 10s of km and even further during heavy weather conditions. Longer wavelengths of 2100 nm and 2450 nm are also presented, this spectrum band is of great interest for direct infrared countermeasure (DIRCM) applications. State-of-the-art SWIR and LWIR electro-optical systems are presented. Sensitive InGaAs sensors coupled with "fast" (low F/#) optical lenses can provide complete night vision, detection of all NIR and SWIR laser lines, penetration through smoke, dust and fog. Finally beyond-state-of-the-art uncooled micro-bolometer LWIR systems are presented featuring ultra-high sensor sensitivities of 20 mK.

  5. NIR Capturing images with spectral information in the mid-infrared

    DEFF Research Database (Denmark)

    Dam, Jeppe Seidelin; Tidemand-Lichtenberg, Peter; Pedersen, Christian

    We demonstrate a method to capture images containing spectral information in the infrared. The method is based on sum frequency mixing of light, which allows for transformation of mid-infrared radiation to near visible light, allowing for use of a regular silicon based camera for detection. Combi...

  6. Dual Language Use in Sign-Speech Bimodal Bilinguals: fNIRS Brain-Imaging Evidence

    Science.gov (United States)

    Kovelman, Ioulia; Shalinsky, Mark H.; White, Katherine S.; Schmitt, Shawn N.; Berens, Melody S.; Paymer, Nora; Petitto, Laura-Ann

    2009-01-01

    The brain basis of bilinguals' ability to use two languages at the same time has been a hotly debated topic. On the one hand, behavioral research has suggested that bilingual dual language use involves complex and highly principled linguistic processes. On the other hand, brain-imaging research has revealed that bilingual language switching…

  7. Comparison between visible/ NIR spectroscopy and hyperspectral imaging for detecting surface contaminants on poultry carcasses

    Science.gov (United States)

    The U. S. Department of Agriculture, Agricultural Research Service has been developing a method and system to detect fecal contamination on processed poultry carcasses with hyperspectral and multispectral imaging systems. The patented method utilizes a three step approach to contaminant detection. S...

  8. Nonintrusive Finger-Vein Recognition System Using NIR Image Sensor and Accuracy Analyses According to Various Factors

    Directory of Open Access Journals (Sweden)

    Tuyen Danh Pham

    2015-07-01

    Full Text Available Biometrics is a technology that enables an individual person to be identified based on human physiological and behavioral characteristics. Among biometrics technologies, face recognition has been widely used because of its advantages in terms of convenience and non-contact operation. However, its performance is affected by factors such as variation in the illumination, facial expression, and head pose. Therefore, fingerprint and iris recognitions are preferred alternatives. However, the performance of the former can be adversely affected by the skin condition, including scarring and dryness. In addition, the latter has the disadvantages of high cost, large system size, and inconvenience to the user, who has to align their eyes with the iris camera. In an attempt to overcome these problems, finger-vein recognition has been vigorously researched, but an analysis of its accuracies according to various factors has not received much attention. Therefore, we propose a nonintrusive finger-vein recognition system using a near infrared (NIR image sensor and analyze its accuracies considering various factors. The experimental results obtained with three databases showed that our system can be operated in real applications with high accuracy; and the dissimilarity of the finger-veins of different people is larger than that of the finger types and hands.

  9. Nonintrusive Finger-Vein Recognition System Using NIR Image Sensor and Accuracy Analyses According to Various Factors.

    Science.gov (United States)

    Pham, Tuyen Danh; Park, Young Ho; Nguyen, Dat Tien; Kwon, Seung Yong; Park, Kang Ryoung

    2015-07-13

    Biometrics is a technology that enables an individual person to be identified based on human physiological and behavioral characteristics. Among biometrics technologies, face recognition has been widely used because of its advantages in terms of convenience and non-contact operation. However, its performance is affected by factors such as variation in the illumination, facial expression, and head pose. Therefore, fingerprint and iris recognitions are preferred alternatives. However, the performance of the former can be adversely affected by the skin condition, including scarring and dryness. In addition, the latter has the disadvantages of high cost, large system size, and inconvenience to the user, who has to align their eyes with the iris camera. In an attempt to overcome these problems, finger-vein recognition has been vigorously researched, but an analysis of its accuracies according to various factors has not received much attention. Therefore, we propose a nonintrusive finger-vein recognition system using a near infrared (NIR) image sensor and analyze its accuracies considering various factors. The experimental results obtained with three databases showed that our system can be operated in real applications with high accuracy; and the dissimilarity of the finger-veins of different people is larger than that of the finger types and hands.

  10. Accelerated weathering-induced degradation of poly(lactic acid) fiber studied by near-infrared (NIR) hyperspectral imaging.

    Science.gov (United States)

    Shinzawa, Hideyuki; Nishida, Masakazu; Tanaka, Toshiyuki; Kanematsu, Wataru

    2012-04-01

    Hydrolysis degradation of a set of drawn poly(lactic acid) (PLA) fibers was induced by an accelerated weathering test, radiating ultraviolet (UV) light under a certain temperature and humidity. The fine features of the transient behavior of the PLA fibers were captured by near-infrared (NIR) hyperspectral imaging. The PLA fibers showed a gradual decrease in mechanical property (e.g., tensile strength), indicating hydrolysis degradation. Thus, the detailed analysis of the spectral variation, in turn, offers useful information on the molecular-level degradation behavior of the drawn PLA fibers. The variation of the spectral intensity as well as band position shift of the crystalline band of PLA was analyzed. The spectral intensity of the crystalline band of PLA showed gradual decrease, suggesting the decrease in molecular weight induced by the hydrolysis degradation. In addition, the crystalline band also exhibited a coinciding shift to the lower wavenumber direction with the weathering test, revealing cleavage-induced crystallization of the PLA samples. Consequently, the hydrolysis degradation induced by the weathering test substantially accelerates predominant degradation of the amorphous structure of the PLA and such variation of the molecular structure, in turn, brings less ductility to the PLA fiber.

  11. NIR area array CCD-based singlet oxygen luminescence imaging for photodynamic therapy

    Energy Technology Data Exchange (ETDEWEB)

    Hu Bolin; He Yonghong; Liu Zhiyi, E-mail: heyh@sz.tsinghua.edu.cn [Laboratory of Optical Imaging and Sensing, Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055 (China)

    2011-01-01

    In this work, a near-infrared CCD-based singlet oxygen luminescence two-dimensional imaging method is proposed to detect singlet oxygen by its 1270nm luminescence. Two-dimensional singlet oxygen images with its near-infrared luminescence during photosensitization could be obtained with a CCD integration time of 1s, without scanning. The data presented shows a linear relationship between the singlet oxygen luminescence intensity and sample concentration. This method provides a detection sensitivity of 0.00189mg/ml (Hematoporphyrin monomethyl Ether dissolved in ethanol) and a spatial resolution better than 100{mu}m. We applied this method in vivo to demonstrate its potential in monitoring photodynamic therapy.

  12. Detection of Fungus Infection on Petals of Rapeseed (Brassica napus L.) Using NIR Hyperspectral Imaging

    Science.gov (United States)

    Zhao, Yan-Ru; Yu, Ke-Qiang; Li, Xiaoli; He, Yong

    2016-12-01

    Infected petals are often regarded as the source for the spread of fungi Sclerotinia sclerotiorum in all growing process of rapeseed (Brassica napus L.) plants. This research aimed to detect fungal infection of rapeseed petals by applying hyperspectral imaging in the spectral region of 874–1734 nm coupled with chemometrics. Reflectance was extracted from regions of interest (ROIs) in the hyperspectral image of each sample. Firstly, principal component analysis (PCA) was applied to conduct a cluster analysis with the first several principal components (PCs). Then, two methods including X-loadings of PCA and random frog (RF) algorithm were used and compared for optimizing wavebands selection. Least squares-support vector machine (LS-SVM) methodology was employed to establish discriminative models based on the optimal and full wavebands. Finally, area under the receiver operating characteristics curve (AUC) was utilized to evaluate classification performance of these LS-SVM models. It was found that LS-SVM based on the combination of all optimal wavebands had the best performance with AUC of 0.929. These results were promising and demonstrated the potential of applying hyperspectral imaging in fungus infection detection on rapeseed petals.

  13. Classification of Salmonella enterica serotypes with selective bands using visible/NIR hyperspectral microscope images.

    Science.gov (United States)

    Eady, M; Park, B

    2016-07-01

    Optical detection of foodborne bacteria such as Salmonella classifies bacteria by analysing spectral data, and has potential for rapid detection. In this experiment hyperspectral microscopy is explored as a means for classifying five Salmonella serotypes. Initially, the microscope collects 89 spectral measurements between 450 and 800 nm. Here, the objective was to develop correct classification of five serotypes with optimal spectral bands selected through multivariate data analysis (MVDA), thus reducing the data processing and storage requirement necessary for practical application in the food industry. An upright digital microscope is equipped with an acousto-optical tuneable filter, electron multiplying charge-coupled device, and metal halide lighting source. Images for each of the five serotypes were collected, and informative bands were identified through a principal component analysis, for four abbreviated spectral ranges containing 3, 7, 12 and 20 spectral bands. The experiment was repeated with an independent repetition and images were collected at each of the reduced band sets, identified by the first repetition. A support vector machine (SVM) was used to classify serotypes. Results showed that with the first repetition, classification accuracy decreased from 99.5% (89 bands) to 84.5% (3 bands), whereas the second repetition showed classification accuracies of 100%, possibly due to a reduction in spectral noise. The support vector machine regression (SVMR) was applied with cross-validation, and had R(2) calibration and validation values >0.922. Although classification accuracies through SVM classification showed that as little as 3 bands were able to classify 100% of the samples, the SVMR shows that the smallest root-mean squared-error values were 0.001 and 0.002 for 20 and 12 bands, respectively, suggesting that the 12 band range collected between 586 and 630 nm is optimal for classifying bacterial serotypes, with only the informative HMI bands selected.

  14. Imaging C. elegans with thiolated tryptophan-based NIR fluorescent gold nanoclusters

    Energy Technology Data Exchange (ETDEWEB)

    Barman, Apurba Kr. [Indian Institute of Technology Kanpur, Department of Chemistry (India); Chaturbedi, Amaresh; Subramaniam, K. [Indian Institute of Technology Kanpur, Department of Biological Sciences and Bioengineering (India); Verma, Sandeep, E-mail: sverma@iitk.ac.in [Indian Institute of Technology Kanpur, Department of Chemistry (India)

    2013-11-15

    Multidentate, thiolated, tryptophan-containing peptide conjugates were synthesized for the preparation of gold nanoclusters (AuNCs). Precursor Au{sub 11}(PPh{sub 3}){sub 8}Cl{sub 3} was prepared by the reduction of HAuCl{sub 4}, followed by the use of tryptophan-containing peptide conjugates in ligand displacement reactions, to afford near-infrared fluorescent AuNCs. The emission maxima for these newly synthesized AuNCs were ∼715 nm. AuNCs were characterized with the help of UV–Vis, FTIR, fluorescence and MALDI analysis. FTIR spectra showed that the ligands bind to Au atoms through Au–S bonds, while MALDI mass spectra revealed that the clusters consisted of 20–23 Au atoms. Introduction of hydrophilic –COOH groups engendered water solubility to these AuNCs, enabling bioimaging applications. We demonstrate fluorescence imaging of the nematode C. elegans and confirm distribution of these AuNCs in nematode gut with the help of green fluorescent protein co-localization experiments.

  15. Nondestructive Detection and Quantification of Blueberry Bruising using Near-infrared (NIR) Hyperspectral Reflectance Imaging

    Science.gov (United States)

    Jiang, Yu; Li, Changying; Takeda, Fumiomi

    2016-10-01

    Currently, blueberry bruising is evaluated by either human visual/tactile inspection or firmness measurement instruments. These methods are destructive, time-consuming, and subjective. The goal of this paper was to develop a non-destructive approach for blueberry bruising detection and quantification. Experiments were conducted on 300 samples of southern highbush blueberry (Camellia, Rebel, and Star) and on 1500 samples of northern highbush blueberry (Bluecrop, Jersey, and Liberty) for hyperspectral imaging analysis, firmness measurement, and human evaluation. An algorithm was developed to automatically calculate a bruise ratio index (ratio of bruised to whole fruit area) for bruise quantification. The spectra of bruised and healthy tissues were statistically separated and the separation was independent of cultivars. Support vector machine (SVM) classification of the spectra from the regions of interest (ROIs) achieved over 94%, 92%, and 96% accuracy on the training set, independent testing set, and combined set, respectively. The statistical results showed that the bruise ratio index was equivalent to the measured firmness but better than the predicted firmness in regard to effectiveness of bruise quantification, and the bruise ratio index had a strong correlation with human assessment (R2 = 0.78 - 0.83). Therefore, the proposed approach and the bruise ratio index are effective to non-destructively detect and quantify blueberry bruising.

  16. Nondestructive Detection and Quantification of Blueberry Bruising using Near-infrared (NIR) Hyperspectral Reflectance Imaging

    Science.gov (United States)

    Jiang, Yu; Li, Changying; Takeda, Fumiomi

    2016-01-01

    Currently, blueberry bruising is evaluated by either human visual/tactile inspection or firmness measurement instruments. These methods are destructive, time-consuming, and subjective. The goal of this paper was to develop a non-destructive approach for blueberry bruising detection and quantification. Experiments were conducted on 300 samples of southern highbush blueberry (Camellia, Rebel, and Star) and on 1500 samples of northern highbush blueberry (Bluecrop, Jersey, and Liberty) for hyperspectral imaging analysis, firmness measurement, and human evaluation. An algorithm was developed to automatically calculate a bruise ratio index (ratio of bruised to whole fruit area) for bruise quantification. The spectra of bruised and healthy tissues were statistically separated and the separation was independent of cultivars. Support vector machine (SVM) classification of the spectra from the regions of interest (ROIs) achieved over 94%, 92%, and 96% accuracy on the training set, independent testing set, and combined set, respectively. The statistical results showed that the bruise ratio index was equivalent to the measured firmness but better than the predicted firmness in regard to effectiveness of bruise quantification, and the bruise ratio index had a strong correlation with human assessment (R2 = 0.78 − 0.83). Therefore, the proposed approach and the bruise ratio index are effective to non-destructively detect and quantify blueberry bruising. PMID:27767050

  17. High-speed monitoring of the crystallinity change in poly(lactic acid) during photodegradation by using a newly developed wide area NIR imaging system (Compovision).

    Science.gov (United States)

    Ishikawa, Daitaro; Furukawa, Daiki; Wei, Tseng Tsai; Reddy, Kummetha Raghunatha; Motomura, Asako; Igarashi, Yoko; Sato, Harumi; Kazarian, Sergei G; Ozaki, Yukihiro

    2015-01-01

    We aimed to achieve wide area rapid monitoring of the crystallinity change in poly(lactic acid) (PLA) during photodegradation caused by ultraviolet (UV) light by using a newly developed near-infrared (NIR) camera (Compovison). Several kinds of PLA samples with different crystallinities and their blends with poly[(3)-(R)-hydroxybutyrate] were prepared. Their two-dimensional NIR spectra in the 1,000-2,350-nm region were measured by Compovision at a 5-min interval during photolysis. An intensity decrease of the band in the 1,900-1,925-nm region due to the second overtone of the C = O stretching vibration of PLA was observed during photolysis. This suggests that an anhydride carbonyl is produced during photolysis. The NIR image of the crystallinity change monitored by the band at 1,917 nm in the standard normal variate spectra clearly shows the inhomogeneity of crystal evolution. A logarithmic increase was observed for all identified areas in the PLA film; however, the time to reach the maximum crystallinity was slightly different according to the initial crystallinity of the sample. It is likely that the initial crystallinity of the sample influences the degradation speed more than the degradation amount. These imaging results have provided fundamental chemical insights into the photolytic process for PLA, and at the same time they have demonstrated that the two-dimensional spectral data obtained by Compovision are useful for process monitoring of polymers.

  18. NIR Imaging Spectroscopy of the Inner Few Arcseconds of NGC 4151 with OSIRIS at Keck

    Science.gov (United States)

    Iserlohe, Christof; Krabbe, Alfred; Larkin, James E.; Barczys, Matthew; McElwain, Michael W.; Quirrenbach, Andreas; Weiss, Jason; Wright, Shelley A.

    2013-01-01

    We present H- and K-band data from the inner arcsecond of the Seyfert 1.5 galaxy NGC 4151 obtained with the adaptive optics assisted near-infrared imaging field spectrograph OSIRIS at the Keck Observatory. The angular resolution is about a few parsecs on-site and thus competes easily with optical images taken previously with the Hubble Space Telescope. We present the morphology and dynamics of most species detected but focus on the morphology and dynamics of the narrow line region (as traced by emission of [FeII]?1.644 µm), the interplay between plasma ejected from the nucleus (as traced by 21 cm continuum radio data) and hot H2 gas and characterize the detected nuclear HeI?2.058 µm absorption feature as a narrow absorption line (NAL) phenomenon. Emission from the narrow line region (NLR) as traced by [FeII] reveals a biconical morphology and we compare the measured dynamics in the [FeII] emission line with models proposing acceleration of gas in the NLR and simple ejection of gas into the NLR. In the inner 2.5 arcseconds the acceleration model reveals a better fit to our data than the ejection model.We also see evidence that the jet very locally enhances emission in [FeII] at certain positions in our field-of-view such that we were able to distinct the kinematics of these clouds from clouds generally accelerated in the NLR. Further, the radio jet is aligned with the bicone surface rather than the bicone axis such that we assume that the jet is not the dominant mechanism responsible for driving the kinematics of clouds in the NLR. The hot H2 gas is thermal with a temperature of about 1700 K. We observe a remarkable correlation between individual H2 clouds at systemic velocity with the 21 cm continuum radio jet. We propose that the radio jet is at least partially embedded in the galactic disk of NGC 4151 such that deviations from a linear radio structure are invoked by interactions of jet plasma with H2 clouds that are moving into the path of the jet because of

  19. Application of NIR hyperspectral imaging for post-consumer polyolefins recycling

    Science.gov (United States)

    Serranti, Silvia; Gargiulo, Aldo; Bonifazi, Giuseppe

    2012-06-01

    An efficient large-scale recycling approach of particulate solid wastes is always accomplished according to the quality of the materials fed to the recycling plant and/or to any possible continuous and reliable control of the different streams inside the processing plants. Processing technologies addressed to recover plastics need to be extremely powerful, since they must be relatively simple to be cost-effective, but also accurate enough to create high-purity products and able to valorize a substantial fraction of the plastic waste materials into useful products of consistent quality in order to be economical. On the other hand, the potential market for such technologies is large and the boost of environmental regulations, and the oil price increase, has made many industries interested both in "general purpose" waste sorting technologies, as well as in developing more specialized sensing devices and/or inspection logics for a better quality assessment of plastic products. In this perspective recycling strategies have to be developed taking into account some specific aspects as i) mixtures complexity: the valuable material has to be extracted from the residue, ii) overall production: the profitability of plastic can be achieved only with mass production and iii) costs: low-cost sorting processes are required. In this paper new analytical strategies, based on hyperspectral imaging in the near infrared field (1000-1700 nm), have been investigated and set up in order to define sorting and/or quality control logics that could be profitably applied, at industrial plant level, for polyolefins recycling.

  20. Transferring results from NIR-hyperspectral to NIR-multispectral imaging systems: A filter-based simulation applied to the classification of Arabica and Robusta green coffee.

    Science.gov (United States)

    Calvini, Rosalba; Amigo, Jose Manuel; Ulrici, Alessandro

    2017-05-15

    Due to the differences in terms of both price and quality, the availability of effective instrumentation to discriminate between Arabica and Robusta coffee is extremely important. To this aim, the use of multispectral imaging systems could provide reliable and accurate real-time monitoring at relatively low costs. However, in practice the implementation of multispectral imaging systems is not straightforward: the present work investigates this issue, starting from the outcome of variable selection performed using a hyperspectral system. Multispectral data were simulated considering four commercially available filters matching the selected spectral regions, and used to calculate multivariate classification models with Partial Least Squares-Discriminant Analysis (PLS-DA) and sparse PLS-DA. Proper strategies for the definition of the training set and the selection of the most effective combinations of spectral channels led to satisfactory classification performances (100% classification efficiency in prediction of the test set). Copyright © 2017 Elsevier B.V. All rights reserved.

  1. Near-infrared chemical imaging (NIR-CI) as a process monitoring solution for a production line of roll compaction and tableting.

    Science.gov (United States)

    Khorasani, Milad; Amigo, José M; Sun, Changquan Calvin; Bertelsen, Poul; Rantanen, Jukka

    2015-06-01

    In the present study the application of near-infrared chemical imaging (NIR-CI) supported by chemometric modeling as non-destructive tool for monitoring and assessing the roller compaction and tableting processes was investigated. Based on preliminary risk-assessment, discussion with experts and current work from the literature the critical process parameter (roll pressure and roll speed) and critical quality attributes (ribbon porosity, granule size, amount of fines, tablet tensile strength) were identified and a design space was established. Five experimental runs with different process settings were carried out which revealed intermediates (ribbons, granules) and final products (tablets) with different properties. Principal component analysis (PCA) based model of NIR images was applied to map the ribbon porosity distribution. The ribbon porosity distribution gained from the PCA based NIR-CI was used to develop predictive models for granule size fractions. Predictive methods with acceptable R(2) values could be used to predict the granule particle size. Partial least squares regression (PLS-R) based model of the NIR-CI was used to map and predict the chemical distribution and content of active compound for both roller compacted ribbons and corresponding tablets. In order to select the optimal process, setting the standard deviation of tablet tensile strength and tablet weight for each tablet batch was considered. Strong linear correlation between tablet tensile strength and amount of fines and granule size was established, respectively. These approaches are considered to have a potentially large impact on quality monitoring and control of continuously operating manufacturing lines, such as roller compaction and tableting processes.

  2. InGaAs focal plane array developments at III-V Lab

    Science.gov (United States)

    Rouvié, Anne; Reverchon, Jean-Luc; Huet, Odile; Djedidi, Anis; Robo, Jean-Alexandre; Truffer, Jean-Patrick; Bria, Toufiq; Pires, Mauricio; Decobert, Jean; Costard, Eric

    2012-06-01

    SWIR detection band benefits from natural (sun, night glow, thermal radiation) or artificial (eye safe lasers) photons sources combined to low atmospheric absorption and specific contrast compared to visible wavelengths. It gives the opportunity to address a large spectrum of applications such as defense and security (night vision, active imaging), space (earth observation), transport (automotive safety) or industry (non destructive process control). InGaAs material appears as a good candidate to satisfy SWIR detection needs. The lattice matching with InP constitutes a double advantage to this material: attractive production capacity and uncooled operation thanks to low dark current level induced by high quality material. For few years, III-VLab has been studying InGaAs imagery, gathering expertise in InGaAs material growth and imaging technology respectively from Alcatel-Lucent and Thales, its two mother companies. This work has lead to put quickly on the market a 320x256 InGaAs module, exhibiting high performances in terms of dark current, uniformity and quantum efficiency. In this paper, we present the last developments achieved in our laboratory, mainly focused on increasing the pixels number to VGA format associated to pixel pitch decrease (15μm) and broadening detection spectrum toward visible wavelengths. Depending on targeted applications, different Read Out Integrated Circuits (ROIC) have been used. Low noise ROIC have been developed by CEA LETI to fit the requirements of low light level imaging whereas logarithmic ROIC designed by NIT allows high dynamic imaging adapted for automotive safety.

  3. Design of an FT-NIR spectrometer for online quality analysis of traditional Chinese medicine manufacturing process

    Science.gov (United States)

    Zhu, Ren; Wu, Lan; Wang, Shiming; Ye, Linhua; Ding, Zhihua

    2008-03-01

    As a fast, non-destructive analysis method, Fourier transform (FT) near-infrared (NIR) spectroscopy is very suitable and effective for online quality analysis of traditional Chinese medicine (TCM) manufacturing process. In this thesis, the theoretics of FT-NIRS was analyzed and an FT-NIR spectrometer with 4 cm -1 resolution in the 12500-5000 cm -1 frequency range was designed. The spectrometer was based on a Michelson interferometer with Bromine tungsten lamp as the NIR light source and InGaAs detector to collect the interference signal. Each element was designed and chosen to provide maximum sensitivity in the NIR spectral region. A fiber-optic flow cell system was used to realize online analysis of traditional Chinese medicine. The performance of the spectrometer was evaluated and the feasibility of using FT-NIR spectrometer to get absorption spectra of traditional Chinese medicine was demonstrated.

  4. Short wave infrared InGaAs focal plane arrays detector: the performance optimization of photosensitive element

    Science.gov (United States)

    Gao, Xin-jiang; Tang, Zun-lie; Zhang, Xiu-chuan; Chen, Yang; Jiang, Li-qun; Cheng, Hong-bing

    2009-07-01

    Significant progress has been achieved in technology of the InGaAs focal plane arrays (FPA) detector operating in short wave infrared (SWIR) last two decades. The no cryogenic cooling, low manufacturing cost, low power, high sensitivity and maneuverability features inherent of InGaAs FPA make it as a mainstream SWIR FPA in a variety of critical military, national security, aerospace, telecommunications and industrial applications. These various types of passive image sensing or active illumination image detecting systems included range-gated imaging, 3-Dimensional Ladar, covert surveillance, pulsed laser beam profiling, machine vision, semiconductor inspection, free space optical communications beam tracker, hyperspectroscopy imaging and many others. In this paper the status and perspectives of hybrid InGaAs FPA which is composed of detector array (PDA) and CMOS readout integrate circuit (ROIC) are reviewed briefly. For various low light levels applications such as starlight or night sky illumination, we have made use of the interface circuit of capacitive feedback transimpedance amplifier (CTIA) in which the integration capacitor was adjustable, therefore implements of the physical and electrical characteristics matches between detector arrays and readout intergrate circuit was achieved excellently. Taking into account the influences of InGaAs detector arrays' optoelectronic characteristics on performance of the FPA, we discussed the key parameters of the photodiode in detailed, and the tradeoff between the responsivity, dark current, impedance at zero bias and junction capacitance of photosensitive element has been made to root out the impact factors. As a result of the educed approach of the photodiode's characteristics optimizing which involve with InGaAs PDA design and process, a high performance InGaAs FPA of 30um pixel pitch and 320×256 format has been developed of which the response spectrum range over 0.9um to 1.7um, the mean peak detectivity (λ=1.55

  5. A "win-win" nanoplatform: TiO2:Yb,Ho,F for NIR light-induced synergistic therapy and imaging.

    Science.gov (United States)

    Zhou, Jie; Luo, Pei; Sun, Chong; Meng, Lingchang; Ye, Weiran; Chen, Shanshan; Du, Bin

    2017-03-23

    To avoid the defect of low energy transfer efficiency in core-shell UCNP-TiO2 NPs, doping rare earth into TiO2 and improving the photocatalytic activity of TiO2 itself under Vis-NIR light might be a more direct and efficient strategy for high (1)O2 production. Here, we designed a TiO2:Yb,Ho,F-β-CD@DTX/HA nanoplatform using TiO2:Yb,Ho,F as the core, β-CD as the drug carrier, hyaluronic acid (HA) as the capping agent and target, and then applied it for 808 nm induced photodynamic-chemotherapy and 980 nm upconversion fluorescence/MR imaging. The results were as follows: (i) for TiO2 as a photosensitizer, after doping Yb, Ho, F into TiO2, it could directly generate reactive oxygen species under an 808 nm laser; the dopants enhanced the absorption under the UV-Vis-NIR region and increased the electron-hole pair separation. (ii) For TiO2 as the upconversion host, F and Ho also endowed TiO2:Yb,Ho,F with enhanced upconversion fluorescence under a 980 nm laser and T2-MRI contrast performance (r2 = 30.71 mM(-1) s(-1)), respectively, thus, facilitating imaging for deep tissues. (iii) The HA shell outside of β-CD prevented the unexpected leaking of DTX, which improved the target abilities and achieved the enzyme-responsive drug release. The in vitro and in vivo studies also demonstrated the nanosystem could efficiently suppress tumor growth by combination therapy and had excellent imaging (UCL/MR) ability. Particularly, our work was the first example that utilized TiO2 simultaneously as a photosensitizer and upconversion host, which simplified the core-shell UCNP-TiO2 nanocomposites and reached a "win-win" cooperation in NIR-induced photodynamic therapy and UCL imaging.

  6. NIR Analysis for Textiles

    Science.gov (United States)

    Near Infrared (NIR) spectroscopy has been found to be a useful technique to characterize raw materials and finished textile products, and NIR methods and techniques continue to find increasingly diverse and wide-ranging quantitative and qualitative applications in the textile industry. NIR methods ...

  7. Measurement of neuronal activity in a macaque monkey in response to animate images using near-infrared spectroscopy (NIRS

    Directory of Open Access Journals (Sweden)

    Masumi Wakita

    2010-06-01

    Full Text Available Near-infrared spectroscopy (NIRS has been used extensively for functional neuroimaging over the past decade, in part because it is considered a powerful tool for investigating brain function in human infants and young children, for whom other neuroimaging techniques are not suitable. In particular, several studies have measured hemodynamic responses in the occipital region in infants upon exposure to visual stimuli. In the present study, we used a multi-channel NIRS to measure neuronal activity in a macaque monkey who was trained to watch videos showing various circus animals performing acrobatic activities without fixing the head position of the monkey. Cortical activity from the occipital region was measured first by placing a probe comprising a 3x5 array of emitters and detectors (2 x 4 cm on the area (area 17, and the robustness and stability of the results were confirmed across sessions. Cortical responses were then measured from the dorsofrontal region. The oxygenated hemoglobin signals increased in area 9 and decreased in area 8b in response to viewing the videos. The results suggest that these regions are involved in cognitive processing of visually presented stimuli. The monkey showed positive responsiveness to the stimuli from the affective standpoint, but its attentional response to them was an inhibitory one.

  8. Near-IR and PS-OCT imaging of developmental defects in dental enamel

    Science.gov (United States)

    Hirasuna, Krista; Fried, Daniel; Darling, Cynthia L.

    2007-02-01

    Polarization sensitive optical coherence tomography (PS-OCT) and near-IR (NIR) imaging are promising new technologies under development for monitoring early carious lesions. Fluorosis is a growing problem in the U.S., and the more prevalent mild fluorosis can be visually mistaken for early enamel demineralization. Some initial NIR images suggest that enamel defects and dental caries manifest different optical behavior in the NIR. Unfortunately, there is little quantitative information available regarding the differences in optical properties of sound enamel, enamel developmental defects, and demineralized enamel due to caries. This study tested the hypothesis that hypomineralized enamel due to fluorosis can be differentiated from demineralized enamel due to caries using NIR and PS-OCT imaging because of different optical behavior in the NIR. Thirty extracted human teeth with various degrees of suspected fluorosis and/or caries were imaged using PS-OCT and NIR transillumination. An InGaAs camera and a near-IR diode laser were used to measure the optical attenuation through transverse tooth sections (~200 μm). Developmental defects were clearly visible in the polarization-resolved OCT images, demonstrating that PS-OCT can be used to nondestructively measure the depth and possible severity of the defects. Enamel defects on whole teeth that could be imaged with high contrast with visible light were transparent in the near-IR while demineralized areas due to caries were opaque. In contrast, dental caries could be clearly distinguished from sound enamel. This study suggests that PS-OCT and NIR methods may potentially be used as tools to assess the severity and extent of enamel defects and for the differentiation of mild fluorosis defects from early carious lesions.

  9. The development of InGaAs short wavelength infrared focal plane arrays with high performance

    Science.gov (United States)

    Li, Xue; Gong, Haimei; Fang, Jiaxiong; shao, Xiumei; Tang, Hengjing; Huang, Songlei; Li, Tao; Huang, Zhangcheng

    2017-01-01

    High performance, various specifications InGaAs focal plane arrays(FPAs) were studied in Shanghai Institute of Technical Physics (SITP). On the one hand, the typical linear 256 × 1, 512 × 1 and 1024 × 1 FPAs were obtained for response wavelengths from 0.9 μm to 1.7 μm. The typical 320 × 256 FPAs and special sizes 512 × 128, 512 × 256 FPAs for the near infrared multi-spectral imaging were studied. The performance of InGaAs FPAs from 0.9 μm to 1.7 μm has improved enormously. The average peak detectivity, the response non-uniformity and non-operable pixel of the FPAs are superior to 3 × 1012 cm Hz1/2/W, 5% and 1% at the room temperature. On the other hand, the development of the extended InGaAs FPAs was also focused in SITP. The dark current of InGaAs detectors with the response wavelength from 1.0 μm to 2.5 μm decreases to about 10 nA/cm2 at 200 K. The dark current mechanisms for extended InGaAs detectors were studied by P/A photodiodes. The special sizes 512 × 256 FPAs has been fabricated since 2011. The average peak detectivity, the response non-uniformity and non-operable pixel of the FPAs are superior to 5 × 1011 cm Hz1/2/W, 8% and 2% at 200 K. In order to verify the performance of FPAs, the short wavelength infrared lens was used to form optical imaging system. The buildings, water, trees are sharply imaged by 320 × 256 FPAs with 0.9-1.7 μm wavelength and 512 × 1 FPAs with 0.9-2.5 μm wavelength at about hundreds of meters distance as target at daylight.

  10. Advanced MEMS spectral sensor for the NIR

    Science.gov (United States)

    Antila, Jarkko E.; Kantojärvi, Uula; Mäkynen, Jussi; Tammi, Matti; Suhonen, Janne

    2015-02-01

    Near Infrared (NIR) spectrometers are widely used in many fields to measure material content, such as moisture, fat and protein in grains, foodstuffs and pharmaceutical powders. These fields include applications where only highly miniaturized and robust NIR sensors can be used due to small usable space, weight requirements and/or hostile working environment. Handheld devices for material inspection, online process automation and automotive industry introduce requirements for size, robustness and cost, which is currently difficult to meet. In this paper we present an advanced spectral sensor based on a tunable Microelectromechanical (MEMS) Fabry-Perot Interferometer. The sensor is fibercoupled, weighs 125 grams and fits to an envelope of 25x55x55 mm3. Three types of sensors cover the wavelength ranges from 1.35-1.7 μm, 1.55-2.0 μm and 1.7-2.2 μm, utilizing only a single pixel extended InGaAs detector, avoiding the expensive linear array detectors. We describe the design, principle of operation and calibration methods together with the control schemes. Some environmental tests are described and their results and finally application measurement results are presented along with discussion and conclusions.

  11. Digital soil classification and elemental mapping using imaging Vis-NIR spectroscopy: How to explicitly quantify stagnic properties of a Luvisol under Norway spruce

    Science.gov (United States)

    Kriegs, Stefanie; Buddenbaum, Henning; Rogge, Derek; Steffens, Markus

    2015-04-01

    Laboratory imaging Vis-NIR spectroscopy of soil profiles is a novel technique in soil science that can determine quantity and quality of various chemical soil properties with a hitherto unreached spatial resolution in undisturbed soil profiles. We have applied this technique to soil cores in order to get quantitative proof of redoximorphic processes under two different tree species and to proof tree-soil interactions at microscale. Due to the imaging capabilities of Vis-NIR spectroscopy a spatially explicit understanding of soil processes and properties can be achieved. Spatial heterogeneity of the soil profile can be taken into account. We took six 30 cm long rectangular soil columns of adjacent Luvisols derived from quaternary aeolian sediments (Loess) in a forest soil near Freising/Bavaria using stainless steel boxes (100×100×300 mm). Three profiles were sampled under Norway spruce and three under European beech. A hyperspectral camera (VNIR, 400-1000 nm in 160 spectral bands) with spatial resolution of 63×63 µm² per pixel was used for data acquisition. Reference samples were taken at representative spots and analysed for organic carbon (OC) quantity and quality with a CN elemental analyser and for iron oxides (Fe) content using dithionite extraction followed by ICP-OES measurement. We compared two supervised classification algorithms, Spectral Angle Mapper and Maximum Likelihood, using different sets of training areas and spectral libraries. As established in chemometrics we used multivariate analysis such as partial least-squares regression (PLSR) in addition to multivariate adaptive regression splines (MARS) to correlate chemical data with Vis-NIR spectra. As a result elemental mapping of Fe and OC within the soil core at high spatial resolution has been achieved. The regression model was validated by a new set of reference samples for chemical analysis. Digital soil classification easily visualizes soil properties within the soil profiles. By combining

  12. Preparation of multi-coloured different sized fluorescent gold clusters from blue to NIR, structural analysis of the blue emitting Au7 cluster, and cell-imaging by the NIR gold cluster.

    Science.gov (United States)

    Roy, Subhasish; Baral, Abhishek; Bhattacharjee, Rameswar; Jana, Batakrishna; Datta, Ayan; Ghosh, Surajit; Banerjee, Arindam

    2015-02-07

    Blue, green, orange-red, red and NIR emitting gold quantum clusters have been prepared in aqueous media by using a bioactive peptide glutathione (reduced) at physiological pH. Matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) analyses show that the core structure sizes of the five different gold clusters are Au7 (blue), Au16 (green), Au19 (orange-red), Au21 (red) and Au22 (NIR). The photo-stability and pH-stability of these quantum clusters have been measured, and these are photo-stable against continuous UV irradiation for a few hours. They also exhibit moderate to good pH-stability within the pH range of 5-12.5. A computational study reveals the organisation of gold atoms in the thiolate-protected blue quantum cluster and its several structural parameters, including the mode of interaction of ligand molecules with Au atoms in the Au7 cluster. Interestingly, it has been found that NIR emitting gold quantum cluster can easily be internalized into the adenocarcinomic human alveolar basal epithelial cell line (A549 cell line). Moreover, a MTT assay indicates that our NIR emitting gold quantum cluster show very low cytotoxicy to A549 cancer cells.

  13. Magnetic/NIR-responsive drug carrier, multicolor cell imaging, and enhanced photothermal therapy of gold capped magnetite-fluorescent carbon hybrid nanoparticles

    Science.gov (United States)

    Wang, Hui; Cao, Guixin; Gai, Zheng; Hong, Kunlun; Banerjee, Probal; Zhou, Shuiqin

    2015-04-01

    This paper reports a type of multifunctional hybrid nanoparticle (NP) composed of gold nanocrystals coated on and/or embedded in a magnetite-fluorescent porous carbon core-shell NP template (Fe3O4@PC-CDs-Au) for biomedical applications, including magnetic/NIR-responsive drug release, multicolor cell imaging, and enhanced photothermal therapy. The synthesis of the Fe3O4@PC-CDs-Au NPs firstly involves the preparation of core-shell template NPs with magnetite nanocrystals clustered in the cores and fluorescent carbon dots (CDs) embedded in a porous carbon shell, followed by an in situ reduction of silver ions (Ag+) loaded in the porous carbon shell and a subsequent replacement of Ag NPs with Au NPs through a galvanic replacement reaction using HAuCl4 as a precursor. The Fe3O4@PC-CDs-Au NPs can enter the intracellular region and light up mouse melanoma B16F10 cells in multicolor mode. The porous carbon shell, anchored with hydrophilic hydroxyl/carboxyl groups, endows the Fe3O4@PC-CDs-Au NPs with excellent stability in the aqueous phase and a high loading capacity (719 mg g-1) for the anti-cancer drug doxorubicin (DOX). The superparamagnetic Fe3O4@PC-CDs-Au NPs with a saturation magnetization of 23.26 emu g-1 produce localized heat under an alternating magnetic field, which triggers the release of the loaded drug. The combined photothermal effects of the Au nanocrystals and the CDs on/in the carbon shell can not only regulate the release rate of the loaded drug, but also efficiently kill tumor cells under NIR irradiation. Benefitting from their excellent optical properties, their magnetic field and NIR light-responsive drug release capabilities and their enhanced photothermal effect, such nanostructured Fe3O4@PC-CDs-Au hybrid NPs are very promising for simultaneous imaging diagnostics and high efficacy therapy.This paper reports a type of multifunctional hybrid nanoparticle (NP) composed of gold nanocrystals coated on and/or embedded in a magnetite-fluorescent porous

  14. Albumin-NIR dye self-assembled nanoparticles for photoacoustic pH imaging and pH-responsive photothermal therapy effective for large tumors.

    Science.gov (United States)

    Chen, Qian; Liu, Xiaodong; Zeng, Jianfeng; Cheng, Zhenping; Liu, Zhuang

    2016-08-01

    Real-time in vivo pH imaging in the tumor, as well as designing therapies responsive to the acidic tumor microenvironment to achieve optimized therapeutic outcomes have been of great interests in the field of nanomedicine. Herein, a pH-responsive near-infrared (NIR) croconine (Croc) dye is able to induce the self-assembly of human serum albumin (HSA) to form HSA-Croc nanoparticles useful not only for real-time ratiometric photoacoustic pH imaging of the tumor, but also for pH responsive photothermal therapy with unexpected great performance against tumors with relatively large sizes. Such HSA-Croc nanoparticles upon intravenous injection exhibit efficient tumor homing. As the decrease of pH, the absorption of Croc at 810 nm would increase while that at 680 nm would decrease, allowing real-time pH sensing in the tumor by double-wavelength ratiometric photoacoustic imaging, which reveals the largely decreased pH inside the cores of large tumors. Moreover, utilizing HSA-Croc as a pH-responsive photothermal agent, effective photothermal ablation of large tumors is realized, likely owing to the more evenly distributed intratumoral heating compared to that achieved by conventional pH-insensitive photothermal agents, which are effective mostly for tumors with small sizes.

  15. A Brief Review on the Use of Functional Near-Infrared Spectroscopy (fNIRS) for Language Imaging Studies in Human Newborns and Adults

    Science.gov (United States)

    Quaresima, Valentina; Bisconti, Silvia; Ferrari, Marco

    2012-01-01

    Upon stimulation, real time maps of cortical hemodynamic responses can be obtained by non-invasive functional near-infrared spectroscopy (fNIRS) which measures changes in oxygenated and deoxygenated hemoglobin after positioning multiple sources and detectors over the human scalp. The current commercially available transportable fNIRS systems have…

  16. A Brief Review on the Use of Functional Near-Infrared Spectroscopy (fNIRS) for Language Imaging Studies in Human Newborns and Adults

    Science.gov (United States)

    Quaresima, Valentina; Bisconti, Silvia; Ferrari, Marco

    2012-01-01

    Upon stimulation, real time maps of cortical hemodynamic responses can be obtained by non-invasive functional near-infrared spectroscopy (fNIRS) which measures changes in oxygenated and deoxygenated hemoglobin after positioning multiple sources and detectors over the human scalp. The current commercially available transportable fNIRS systems have…

  17. Upconverting and NIR emitting rare earth based nanostructures for NIR-bioimaging.

    Science.gov (United States)

    Hemmer, Eva; Venkatachalam, Nallusamy; Hyodo, Hiroshi; Hattori, Akito; Ebina, Yoshie; Kishimoto, Hidehiro; Soga, Kohei

    2013-12-07

    In recent years, significant progress was achieved in the field of nanomedicine and bioimaging, but the development of new biomarkers for reliable detection of diseases at an early stage, molecular imaging, targeting and therapy remains crucial. The disadvantages of commonly used organic dyes include photobleaching, autofluorescence, phototoxicity and scattering when UV (ultraviolet) or visible light is used for excitation. The limited penetration depth of the excitation light and the visible emission into and from the biological tissue is a further drawback with regard to in vivo bioimaging. Lanthanide containing inorganic nanostructures emitting in the near-infrared (NIR) range under NIR excitation may overcome those problems. Due to the outstanding optical and magnetic properties of lanthanide ions (Ln(3+)), nanoscopic host materials doped with Ln(3+), e.g. Y2O3:Er(3+),Yb(3+), are promising candidates for NIR-NIR bioimaging. Ln(3+)-doped gadolinium-based inorganic nanostructures, such as Gd2O3:Er(3+),Yb(3+), have a high potential as opto-magnetic markers allowing the combination of time-resolved optical imaging and magnetic resonance imaging (MRI) of high spatial resolution. Recent progress in our research on over-1000 nm NIR fluorescent nanoprobes for in vivo NIR-NIR bioimaging will be discussed in this review.

  18. Vis-NIR Hyperspectral and Terahertz Imaging Investigations on a Fresco Painting on "Tavella" by Alessandro Gherardini

    Science.gov (United States)

    Doria, A.; Gallerano, G. P.; Giovenale, E.; Casini, A.; Cucci, C.; Picollo, M.; Poggesi, M.; Stefani, L.; Fukunaga, K.; Tamassia, M.

    2017-04-01

    In this paper, we report on Vis-IR hyperspectral and terahertz imaging investigations carried out on a fresco painting on tavella depicting St. John Baptist, by Alessandro Gherardini (1655-1726). Measurements took place at the Restoration Laboratories of the former "Polo Museale della Toscana," in Florence, in the framework of the Italy-Japan collaborative project THz-ARTE. We show how the hyperspectral data made it possible to determine the state-of-conservation of Gherardini's painting, while reflection imaging measurements performed at 97 GHz provided a qualitative evaluation of the position of defects inside the tavella.

  19. Vis-NIR Hyperspectral and Terahertz Imaging Investigations on a Fresco Painting on "Tavella" by Alessandro Gherardini

    Science.gov (United States)

    Doria, A.; Gallerano, G. P.; Giovenale, E.; Casini, A.; Cucci, C.; Picollo, M.; Poggesi, M.; Stefani, L.; Fukunaga, K.; Tamassia, M.

    2017-01-01

    In this paper, we report on Vis-IR hyperspectral and terahertz imaging investigations carried out on a fresco painting on tavella depicting St. John Baptist, by Alessandro Gherardini (1655-1726). Measurements took place at the Restoration Laboratories of the former "Polo Museale della Toscana," in Florence, in the framework of the Italy-Japan collaborative project THz-ARTE. We show how the hyperspectral data made it possible to determine the state-of-conservation of Gherardini's painting, while reflection imaging measurements performed at 97 GHz provided a qualitative evaluation of the position of defects inside the tavella.

  20. Feasibility of detecting aflatoxin B1 on inoculated maize kernels surface using Vis/NIR hyperspectral imaging

    Science.gov (United States)

    The feasibility of using a visible/near-infrared hyperspectral imaging system with a wavelength range between 400 and 1000 nm to detect and differentiate different levels of aflatoxin B1 (AFB1) artificially titrated on maize kernel surface was examined. To reduce the color effects of maize kernels, ...

  1. Discrimination of grassland species and their classification in botanical families by laboratory scale hyperspectral imaging NIR: preliminary results

    Science.gov (United States)

    The objective of this study was to discriminate by on-line hyperspectral imaging, taxonomic plant families comprised of different grassland species. Plants were collected from semi-natural meadows of the National Apuseni Park, Apuseni Mountains, Gârda area (Romania) according to botanical families. ...

  2. Near-infrared (NIR) imaging analysis of polylactic acid (PLA) nanocomposite by multiple-perturbation two-dimensional (2D) correlation spectroscopy

    Science.gov (United States)

    Shinzawa, Hideyuki; Murakami, Takurou N.; Nishida, Masakazu; Kanematsu, Wataru; Noda, Isao

    2014-07-01

    Multiple-perturbation two-dimensional (2D) correlation spectroscopy was applied to sets of near-infrared (NIR) imaging data of polylactic acid (PLA) nanocomposite samples undergoing UV degradation. Incorporation of clay nanoparticles substantially lowers the surface free energy barrier for the nucleation of PLA and eventually increases the frequency of the spontaneous nucleation of PLA crystals. Thus, when exposed to external stimuli such as UV light, PLA nanocomposite may show different structure alternation depending on the clay dispersion. Multiple-perturbation 2D correlation analysis of the PLA nanocomposite samples revealed different spatial variation between crystalline and amorphous structure of PLA, and the phenomenon especially becomes acute in the region where the clay particles are coagulated. The incorporation of the clay leads to the cleavage-induced crystallization of PLA when the sample is subjected to the UV light. The additional development of the ordered crystalline structure then works favorably to restrict the initial degradation of the polymer, providing the delay in the weight loss of the PLA.

  3. Words in the Bilingual Brain: An fNIRS Brain Imaging Investigation of Lexical Processing in Sign-Speech Bimodal Bilinguals

    Directory of Open Access Journals (Sweden)

    Ioulia eKovelman

    2014-08-01

    Full Text Available Early bilingual exposure, especially exposure to two languages in different modalities such as speech and sign, can profoundly affect an individual’s language, culture and cognition. Here we explore the hypothesis that bimodal dual language exposure can also affect the brain’s organization for language. These changes occur across brain regions universally important for language and parietal regions especially critical for sign language (Newman et al., Nature Neuroscience, 2002. We investigated three groups of participants (N=29 that completed a word repetition task in American Sign Language (ASL during fNIRS brain imaging. Those groups were (i hearing ASL-English bimodal bilinguals (n=5, (ii deaf American Sign Language (ASL signers (n=7, and (iii English monolinguals naïve to sign language (n=17. The key finding of the present study is that bimodal bilinguals showed reduced activation in left parietal regions relative to deaf ASL signers when asked to use only ASL. In contrast, this group of bimodal signers showed greater activation in left temporo-parietal regions relative to English monolinguals when asked to switch between their two languages (Kovelman, Petitto et al., 2009. Converging evidence now suggest that bimodal bilingual experience changes the brain bases of language, including the left temporo-parietal regions known to be critical for sign language processing (Emmorey et al., 2007. The results provide insight into the resilience and constraints of neural plasticity for language and bilingualism.

  4. Non-destructive determination of Malondialdehyde (MDA) distribution in oilseed rape leaves by laboratory scale NIR hyperspectral imaging

    Science.gov (United States)

    Kong, Wenwen; Liu, Fei; Zhang, Chu; Zhang, Jianfeng; Feng, Hailin

    2016-10-01

    The feasibility of hyperspectral imaging with 400–1000 nm was investigated to detect malondialdehyde (MDA) content in oilseed rape leaves under herbicide stress. After comparing the performance of different preprocessing methods, linear and nonlinear calibration models, the optimal prediction performance was achieved by extreme learning machine (ELM) model with only 23 wavelengths selected by competitive adaptive reweighted sampling (CARS), and the result was RP = 0.929 and RMSEP = 2.951. Furthermore, MDA distribution map was successfully achieved by partial least squares (PLS) model with CARS. This study indicated that hyperspectral imaging technology provided a fast and nondestructive solution for MDA content detection in plant leaves.

  5. Reflectance conversion methods for the VIS/NIR imaging spectrometer aboard the Chang'E-3 lunar rover: based on ground validation experiment data

    Institute of Scientific and Technical Information of China (English)

    Bin Liu; Jian-Zhong Liu; Guang-Liang Zhang; Zong-Cheng Ling; Jiang Zhang; Zhi-Ping He; Ben-Yong Yang

    2013-01-01

    The second phase of the Chang'E Program (also named Chang'E-3) has the goal to land and perform in-situ detection on the lunar surface.A VIS/NIR imaging spectrometer (VNIS) will be carried on the Chang'E-3 lunar rover to detect the distribution of lunar minerals and resources.VNIS is the first mission in history to perform in-situ spectral measurement on the surface of the Moon,the reflectance data of which are fundamental for interpretation of lunar composition,whose quality would greatly affect the accuracy of lunar element and mineral determination.Until now,in-situ detection by imaging spectrometers was only performed by rovers on Mars.We firstly review reflectance conversion methods for rovers on Mars (Viking landers,Pathfinder and Mars Exploration rovers,etc).Secondly,we discuss whether these conversion methods used on Mars can be applied to lunar in-situ detection.We also applied data from a laboratory bidirectional reflectance distribution function (BRDF) using simulated lunar soil to test the availability of this method.Finally,we modify reflectance conversion methods used on Mars by considering differences between environments on the Moon and Mars and apply the methods to experimental data obtained from the ground validation of VNIS.These results were obtained by comparing reflectance data from the VNIS measured in the laboratory with those from a standard spectrometer obtained at the same time and under the same observing conditions.The shape and amplitude of the spectrum fits well,and the spectral uncertainty parameters for most samples are within 8%,except for the ilmenite sample which has a low albedo.In conclusion,our reflectance conversion method is suitable for lunar in-situ detection.

  6. Logarithmic InGaAs detectors with global shutter and active dark current reduction

    Science.gov (United States)

    Ni, Yang; Arion, Bogdan; Bouvier, Christian; Noguier, Vincent

    2015-05-01

    In this paper, we present newly developed logarithmic InGaAs detectors with global shuttering and also an active dark current reduction technique to ensure ambient temperature operation without TEC for industrial applications. The newly released detectors come with both VGA (15um pitch) and QVGA (25um pitch) resolutions, giving the possibility to use lens less than 1-inch size. The logarithmic response is obtained by using solar-cell mode InGaAs photodiodes. The VGA and QVGA ROICs have 3 analog memories inside each pixel which permit, except the classic ITR, IWR and CDS modes, a new differential imaging mode which can be a useful feature in active imaging systems. The photodiode frontend circuit, in pure voltage mode, is made with non-inverting amplifier instead of CTIA. The reason of this choice is that the exposure time can be shortened without need of excessive power consumption as in CTIA front-end. We think that this arrangement associated with true CDS could match the noise performance of CTIA based one. VGA and QVGA ROICs have been designed and manufactured by using 0.18um 1P4M CMOS process. Both ROIC have been tested with success and match the design targets. The first batch of both detectors is under fabrication and will be presented during the conference.

  7. VIS-NIR Imaging Spectroscopy of Mercury's Surface: SIMBIO-SYS/VIHI Experiment Onboard the BepiColombo

    Science.gov (United States)

    Capaccioni, Fabrizio; de Sanctis, Maria Cristina; Filacchione, Gianrico; Piccioni, Giuseppe; Ammannito, Eleonora; Tommasi, Leonardo; Ficai Veltroni, Iacopo; Cosi, Massimo; Debei, Stefano; Calamai, Luciano; Flamini, Enrico

    2010-07-01

    The Visible and Infrared Hyperspectral Imager (VIHI) is one of the three optical heads of the Spectrometers and Imagers for MPO BepiColombo Integrated Observatory SYStem (SIMBIO-SYS) experiment onboard European Space Agency's BepiColombo cornerstone mission to Mercury. The other two optical heads of SIMBIO-SYS are a stereo camera and a high-resolution image camera. The experiment is designed to scan the Hermean surface from a polar orbit with the three channels to map the physical, morphological, tectonic, and compositional properties of the planet. The main scientific objectives of SIMBIO-SYS are the study of Mercury's surface geology and stratigraphy, the surface composition, the regolith properties, the crustal differentiation, impact, and volcanic processes. The VIHI experiment uses a high-performance optical layout (Schmidt telescope and spectrometer in Littrow configuration) which allows investigating the 400-2000 nm spectral range with 256 spectral channels (6.25 nm/band sampling). The instrument has an instrument field of view (FOV) of 250 microrad corresponding to a spatial scale of about 100 m/pixel at periherm and 375 m at apoherm. The instrument operates in pushbroom configuration, sampling the surface of Mercury with an FOV of 64 x 0.25 mrad. The main technical challenges of this experiment are focal-plane design (cadmium-mercury-telluride thinned to improve the efficiency at visible wavelengths), short dwell time (from about 40 ms at equator to about 100 ms at poles), thermal control, mechanical miniaturization, radiation hardening, high data rate, and compression. A description of the internal calibration unit concept and functionalities is given.

  8. Exciton dephasing in single InGaAs quantum dots

    DEFF Research Database (Denmark)

    Leosson, Kristjan; Østergaard, John Erland; Jensen, Jacob Riis;

    2000-01-01

    . The homogeneous and inhomogeneous broadening of InGaAs quantum dot luminescence is of central importance for the potential application of this material system in optoelectronic devices. Recent measurements of MOCVD-grown InAs/InGaAs quantum dots indicate a large homogeneous broadening at room temperature due...

  9. The NIRS Analysis Package: noise reduction and statistical inference.

    Science.gov (United States)

    Fekete, Tomer; Rubin, Denis; Carlson, Joshua M; Mujica-Parodi, Lilianne R

    2011-01-01

    Near infrared spectroscopy (NIRS) is a non-invasive optical imaging technique that can be used to measure cortical hemodynamic responses to specific stimuli or tasks. While analyses of NIRS data are normally adapted from established fMRI techniques, there are nevertheless substantial differences between the two modalities. Here, we investigate the impact of NIRS-specific noise; e.g., systemic (physiological), motion-related artifacts, and serial autocorrelations, upon the validity of statistical inference within the framework of the general linear model. We present a comprehensive framework for noise reduction and statistical inference, which is custom-tailored to the noise characteristics of NIRS. These methods have been implemented in a public domain Matlab toolbox, the NIRS Analysis Package (NAP). Finally, we validate NAP using both simulated and actual data, showing marked improvement in the detection power and reliability of NIRS.

  10. VLT Diffraction Limited Imaging and Spectroscopy in the NIR: Weighing the black hole in Centaurus A with NACO

    CERN Document Server

    Haering-Neumayer, N; Rix, H W; Hartung, M; Prieto, M A; Meisenheimer, K; Lenzen, R

    2005-01-01

    We present high spatial resolution near-infrared spectra and images of the nucleus of Centaurus A (NGC 5128) obtained with NAOS-CONICA at the VLT. The adaptive optics corrected data have a spatial resolution of 0.06" (FWHM) in K- and 0.11" in H-band. The mean velocities and velocity dispersions of the ionized gas ([FeII]) are mapped along four slit positions. The observed gas motions suggest a kinematically hot disk which is orbiting a central object and is oriented nearly perpendicular to the nuclear jet. We model the central rotation and velocity dispersion curves of the [FeII] gas orbiting in the combined potential of the stellar mass and the (dominant) black hole. Our physically most plausible model, a dynamically hot and geometrically thin gas disk, yields a black hole mass of M_bh = (8.6 +/- 0.3) x 10^7 M_sun. As the physical state of the gas is not well understood, we also consider two limiting cases: first a cold disk model, which completely neglects the velocity dispersion, but is in line with many e...

  11. Fast assessment of the surface distribution of API and excipients in tablets using NIR-hyperspectral imaging.

    Science.gov (United States)

    Franch-Lage, Felicidad; Amigo, José Manuel; Skibsted, Erik; Maspoch, Santiago; Coello, Jordi

    2011-06-15

    The inclusion of hyperspectral imaging systems in the manufacturing and development of pharmaceutical products is allowing a successful improvement in the quality control of solid dosage forms. The correct distribution not only of active pharmaceutical ingredient (API) but also of the rest of excipients is essential to assure the correct behavior of the tablet when ingested. This is especially relevant in tablets with low content of potent APIs, in which the prescribed intake dosage frequently corresponds to half-a-tablet. Therefore, the aim of this work is to study the surface distribution of the compounds in tablets with low API content. The proposed procedure includes the scanning of the tablet surface using near infrared hyperspectral spectroscopy in association with multivariate curve resolution (MCR) techniques to obtain selective pictures for each individual compound and to allow the fast assessment of their distribution in the measured surface. As an example, a set of commercial Lorazepam tablets (approximately 1% mass fraction of API, and four excipients) were analyzed. The results obtained show the capacity of the proposed methodology as an expedite approach to evaluate the uniformity of the contents between and within tablets. A method to estimate the homogeneity distribution of API in the two halves of the tablet is also proposed.

  12. TMS: a navigator for NIRS of the primary motor cortex?

    NARCIS (Netherlands)

    Koenraadt, K.L.; Munneke, M.; Duysens, J.E.J.; Keijsers, N.L.W.

    2011-01-01

    Near-infrared spectroscopy (NIRS) is a non-invasive optical imaging technique, which is increasingly used to measure hemodynamic responses in the motor cortex. The location at which the NIRS optodes are placed on the skull is a major factor in measuring the hemodynamic responses optimally. In this s

  13. NIRS in clinical neurology - a 'promising' tool?

    Science.gov (United States)

    Obrig, Hellmuth

    2014-01-15

    Near-infrared spectroscopy (NIRS) has become a relevant research tool in neuroscience. In special populations such as infants and for special tasks such as walking, NIRS has asserted itself as a low resolution functional imaging technique which profits from its ease of application, portability and the option to co-register other neurophysiological and behavioral data in a 'near natural' environment. For clinical use in neurology this translates into the option to provide a bed-side oximeter for the brain, broadly available at comparatively low costs. However, while some potential for routine brain monitoring during cardiac and vascular surgery and in neonatology has been established, NIRS is largely unknown to clinical neurologists. The article discusses some of the reasons for this lack of use in clinical neurology. Research using NIRS in three major neurologic diseases (cerebrovascular disease, epilepsy and headache) is reviewed. Additionally the potential to exploit the established position of NIRS as a functional imaging tool with regard to clinical questions such as preoperative functional assessment and neurorehabilitation is discussed.

  14. Reversibly monitoring oxidation and reduction events in living biological systems: Recent development of redox-responsive reversible NIR biosensors and their applications in in vitro/in vivo fluorescence imaging.

    Science.gov (United States)

    Chu, Tian-Shu; Lü, Rui; Liu, Bai-Tong

    2016-12-15

    Reactive oxygen species (ROS) and changes in their redox cycles have great therapeutic potential for treating serious redox-related human diseases such as acute and chronic inflammation, diabetes, cancer and neurodegenerative disorders. This article presents a survey of the recently (2011-2016) developed NIR small-molecule biosensors for reversibly monitoring oxidation and reduction events in living cells and small animals through in vitro/in vivo fluorescence imaging. Emission and absorption profile, design strategy and fluorescence sensing mechanism, ROS selectivity and sensitivity, reversibility, ability of subcellular location and cytotoxicity are discussed for the NIR small-molecule biosensors capable of quantitatively, continuously and reversibly detecting transient ROS burst and redox changes at cellular level.

  15. Diversity of nitrite reductase (nirK and nirS) gene fragments in forested upland and wetland soils

    DEFF Research Database (Denmark)

    Priemé, Anders; Braker, Gesche; Tiedje, James M.

    2002-01-01

    The genetic heterogeneity of nitrite reductase gene (nirK and nirS) fragments from denitrifying prokaryotes in forested upland and marsh soil was investigated using molecular methods. nirK gene fragments could be amplified from both soils, whereas nirS gene fragments could be amplified only from...... the marsh soil. PCR products were cloned and screened by restriction fragment length polymorphism (RFLP), and representative fragments were sequenced. The diversity of nirK clones was lower than the diversity of nirS clones. Among the 54 distinct nirK RFLP patterns identified in the two soils, only one...... marsh clones and all upland clones. Only a few of the nirK clone sequences branched with those of known denitrifying bacteria. The nirS clones formed two major clusters with several subclusters, but all nirS clones showed less than 80% identity to nirS sequences from known denitrifying bacteria. Overall...

  16. Noise characteristics analysis of short wave infrared InGaAs focal plane arrays

    Science.gov (United States)

    Yu, Chunlei; Li, Xue; Yang, Bo; Huang, Songlei; Shao, Xiumei; Zhang, Yaguang; Gong, Haimei

    2017-09-01

    The increasing application of InGaAs short wave infrared (SWIR) focal plane arrays (FPAs) in low light level imaging requires ultra-low noise FPAs. This paper presents the theoretical analysis of FPA noise, and point out that both dark current and detector capacitance strongly affect the FPA noise. The impact of dark current and detector capacitance on FPA noise is compared in different situations. In order to obtain low noise performance FPAs, the demand for reducing detector capacitance is higher especially when pixel pitch is smaller, integration time is shorter, and integration capacitance is larger. Several InGaAs FPAs were measured and analyzed, the experiments' results could be well fitted to the calculated results. The study found that the major contributor of FPA noise is coupled noise with shorter integration time. The influence of detector capacitance on FPA noise is more significant than that of dark current. To investigate the effect of detector performance on FPA noise, two kinds of photodiodes with different concentration of the absorption layer were fabricated. The detectors' performance and noise characteristics were measured and analyzed, the results are consistent with that of theoretical analysis.

  17. The implications of Chang'e-3 VIS/NIR Imaging Spectrometer in-situ analysis data

    Science.gov (United States)

    Yao, Meijuan; Zhang, Hongbo; Su, Yan; Liu, Bin; Zhao, Shu; Xue, Xiping

    2015-04-01

    The study of mineralogy helps in understanding the geologic evolution of the lunar mare and the resource of the basalt. The Visible and Near-infrared Imaging Spectrometer (VNIS) as a part of the Chang'e-3 mission is fixed at the front of the rover, which is the first time that VNIS has been developed for in-situ analysis on the lunar surface. According to the spectral feature analysis [1], the landing site could be enriched in olivine which is consistent with the results of Thiessen[2]. Olivine is important to understand the comppsitional and structural evolution of the lunar because it is a main material of the lunar mantle. About the origin of the olivine-rich material, there are two possible scenarios are proposed by Yamamoto et al[3]. One is that the olivine-rich exposures originated in the upper mantle, and the other is in the mafic-rich lower crust. The olivine-rich locations are mostly located along the maria boundaries [3,4]. The geology map of the CE-3 landing site shows that it is within the border of two basalt strata, and the landing site is in the Eratoshenian basalt stratum[5,6].This can be explained that each basin formation could have blasted away the upper crust, excavating and redistributing deep-seated olivine-rich matrrial to the rim[3,4]. A global survey of the lunar surface was conducted using the Spectral profiler onboard the lunar explorer SELENE/Kaguya[3]. It shows that most of the olivine-rich sites are located around impact basins. And around Imbrium, the terrace in the Sinus Iridum is one of the olivine-rich site. The rediative transfer modeling supports the concept that materials in the olvine rich sites originated in the upper mantle[3]. The space weathering could have influence on the mineral spectra, thus the method based on the spectral absorption position can only identify the freshly-exposed minerals. Although further work is required to improve the quality of the VNIS data, and the mineral quantification need to be performed, we

  18. InGaAs Schottky barrier diode array detectors integrated with broadband antenna (Conference Presentation)

    Science.gov (United States)

    Park, Dong Woo; Lee, Eui Su; Park, Jeong-Woo; Kim, Hyun-Soo; Lee, Il-Min; Park, Kyung Hyun

    2017-02-01

    Terahertz (THz) waves have been actively studied for the applications of astronomy, communications, analytical science and bio-technologies due to their low energy and high frequency. For example, THz systems can carry more information with faster rates than GHz systems. Besides, THz waves can be applied to imaging, sensing, and spectroscopy. Furthermore, THz waves can be used for non-destructive and non-harmful tomography of living objects. In this reasons, Schottky barrier diodes (SBD) have been widely used as a THz detector for their ultrafast carrier transport, high responsivity, high sensitivity, and excellent noise equivalent power. Furthermore, SBD detectors envisage developing THz applications at low cost, excellent capability, and high yield. Since the major concerns in the THz detectors for THz imaging systems are the realizations of the real-time image acquisitions via a reduced acquisition time, rather than the conventional raster scans that obtains an image by pixel-by-pixel acquisitions, a line-scan based systems utilizes an array detector with an 1 × n SBD array is preferable. In this study, we fabricated the InGaAs based SBD array detectors with broadband antennas of log-spiral and square-spiral patterns. To optimize leakage current and ideality factor, the dependence to the doping levels of ohmic and Schottky layers have been investigated. In addition, the dependence to the capacitance and resistance to anode size are also examined as well. As a consequence, the real-time THz imaging with our InGaAs SBD array detector have been successfully obtained.

  19. Maturation of the cytochrome cd 1 nitrite reductase NirS from Pseudomonas aeruginosa requires transient interactions between the three proteins NirS, NirN and NirF

    OpenAIRE

    2013-01-01

    The periplasmic cytochrome cd 1 nitrite reductase NirS occurring in denitrifying bacteria such as the human pathogen Pseudomonas aeruginosa contains the essential tetrapyrrole cofactors haem c and haem d 1. Whereas the haem c is incorporated into NirS by the cytochrome c maturation system I, nothing is known about the insertion of the haem d 1 into NirS. Here, we show by co-immunoprecipitation that NirS interacts with the potential haem d 1 insertion protein NirN in vivo. This NirS–NirN inter...

  20. Comparative Research on the NIR and MIR Micro-Imaging of Two Similar Plastic Materials%两种相似塑料材料的显微近、中红外成像方法研究

    Institute of Scientific and Technical Information of China (English)

    王冬; 马智宏; 赵柳; 潘立刚; 李晓婷; 王纪华

    2011-01-01

    显微近、中红外成像不仅可以获得样品的光谱信息,而且可以获得样品的空间分布信息,这是传统的近、中红外光谱分析所无法比拟的.该文以外观非常相似的聚乙烯膜(材料Ⅰ)和封口膜(材料Ⅱ)为研究对象,分别采集了样品的显微近、中红外图像.针对两种材料进行化学成像和相关光谱成像,比较并讨论了每种材料的两种成像方法.结果表明,材料Ⅱ的显微近、中红外化学成像中,两种材料化学成像值相差分别为0.004 8和0.254 8;材料Ⅰ的显微近、中红外化学成像中,两种材料化学成像值相差分别为0.002 6和0.326 5;近、中红外谱区的显微成像皆可得到两种材料清晰的成像,从而可区分两种材料.对两种材料相关光谱成像的研究表明,分别以两种材料的近、中红外光谱作为参比光谱的相关光谱成像可以明显地区分两种材料,成像结果较清晰;显微中红外相关光谱成像中,两种材料的光谱和参比光谱的相关系数差异大于0.12,成像结果更清晰;而显微近红外相关光谱成像图可利用图像中两种材料光谱和参比光谱相关系数的细微差异区分两种材料.该研究为农产品包装材料安全性的快速判别提供一定的参考,并为显微近、中红外成像分辨不同材料提供一定的成像方法参考.%The NIR/MIR micro-imaging can supply not only the information of spectra, but also the information of spacial distribution of the sample, which is superior to the traditional NIR/MIR spectroscopy analysis. In the present paper, polyethylene and parafilm, with similar appearances, were regarded as the research objects, of which the NIR/MIR micro-imaging was collected. Chemical imaging (CD and compare correlation imaging were carried out for the two materials respectively to discuss the imaging methods of the two materials. The result indicated that the differentiation of the CI values of the two materials

  1. Coupling multistripe laser triangulation with hyperspectral imaging VisNIR spectroscopy to elucidate the feedbacks between soil structure, hydrology, and organic matter

    Science.gov (United States)

    Hirmas, Daniel; Steffens, Markus; Sullivan, Pamela; Zhang, Chi; Giménez, Daniel

    2016-04-01

    hours in the laboratory to maximize the expression of the soil structure, moisture was determined for each horizon on a minor amount of soil taken near the edge of the tray after drying, and the monoliths were scanned using an MLT scanner. Images derived from the MLT scanner were binarized and the macropores outlining aggregates were projected on a 2-D plane and analyzed through ImageJ. Subsequently, the monoliths were imaged with a hyperspectral VisNIR camera (spectral resolution: 400-1000 nm in 160 spectral bands; spatial resolution: 63×63 μm2 pixel-1). Results were used to (1) assess the spatial variability of the distribution and properties of macropores; (2) extrapolate elemental concentrations of small sampling areas to the complete image and calculate high-resolution chemometric maps of C, N, Al, Fe and Mn; and (3) produce maps of the chemical composition of SOM. Both the hydraulic properties and the proximity of SOM and the various elements mapped in this study in relation to the occurrence of macropores were used to examine feedbacks between soil structure, hydrology, and SOM. These results as well as the opportunities and limitations for future application of this coupled-sensor approach will be discussed.

  2. Upconverting and NIR emitting rare earth based nanostructures for NIR-bioimaging

    Science.gov (United States)

    Hemmer, Eva; Venkatachalam, Nallusamy; Hyodo, Hiroshi; Hattori, Akito; Ebina, Yoshie; Kishimoto, Hidehiro; Soga, Kohei

    2013-11-01

    In recent years, significant progress was achieved in the field of nanomedicine and bioimaging, but the development of new biomarkers for reliable detection of diseases at an early stage, molecular imaging, targeting and therapy remains crucial. The disadvantages of commonly used organic dyes include photobleaching, autofluorescence, phototoxicity and scattering when UV (ultraviolet) or visible light is used for excitation. The limited penetration depth of the excitation light and the visible emission into and from the biological tissue is a further drawback with regard to in vivo bioimaging. Lanthanide containing inorganic nanostructures emitting in the near-infrared (NIR) range under NIR excitation may overcome those problems. Due to the outstanding optical and magnetic properties of lanthanide ions (Ln3+), nanoscopic host materials doped with Ln3+, e.g. Y2O3:Er3+,Yb3+, are promising candidates for NIR-NIR bioimaging. Ln3+-doped gadolinium-based inorganic nanostructures, such as Gd2O3:Er3+,Yb3+, have a high potential as opto-magnetic markers allowing the combination of time-resolved optical imaging and magnetic resonance imaging (MRI) of high spatial resolution. Recent progress in our research on over-1000 nm NIR fluorescent nanoprobes for in vivo NIR-NIR bioimaging will be discussed in this review.In recent years, significant progress was achieved in the field of nanomedicine and bioimaging, but the development of new biomarkers for reliable detection of diseases at an early stage, molecular imaging, targeting and therapy remains crucial. The disadvantages of commonly used organic dyes include photobleaching, autofluorescence, phototoxicity and scattering when UV (ultraviolet) or visible light is used for excitation. The limited penetration depth of the excitation light and the visible emission into and from the biological tissue is a further drawback with regard to in vivo bioimaging. Lanthanide containing inorganic nanostructures emitting in the near

  3. The "Perceptual Wedge Hypothesis" as the Basis for Bilingual Babies' Phonetic Processing Advantage: New insights from fNIRS Brain Imaging

    Science.gov (United States)

    Petitto, L. A.; Berens, M. S.; Kovelman, I.; Dubins, M. H.; Jasinska, K.; Shalinsky, M.

    2012-01-01

    In a neuroimaging study focusing on young bilinguals, we explored the brains of bilingual and monolingual babies across two age groups (younger 4-6 months, older 10-12 months), using fNIRS in a new event-related design, as babies processed linguistic phonetic (Native English, Non-Native Hindi) and nonlinguistic Tone stimuli. We found that phonetic…

  4. NIR-NIR fluorescence: A new genre of fingermark visualisation techniques.

    Science.gov (United States)

    King, Roberto S P; Hallett, Peter M; Foster, Doug

    2016-05-01

    A preliminary study reveals that finely divided cuprorivaite powder may be used to efficiently develop and subsequently image latent fingermarks across a range of highly patterned, coloured non-porous and semi-porous substrates using near infrared illumination and imaging. Problematic multi-coloured backgrounds provide very little interference under the illumination conditions used, and invoked fluorescence observed, when using this material. This is the first reported example of a NIR-NIR fluorophore for use within latent fingermark visualisation and offers the potential for application at the scene and in the laboratory.

  5. uPAR-targeted optical near-infrared (NIR) fluorescence imaging and PET for image-guided surgery in head and neck cancer

    DEFF Research Database (Denmark)

    Christensen, Anders; Juhl, Karina; Persson, Morten

    2017-01-01

    . Histological analysis showed co-localization of the fluorescent signal, uPAR expression and tumor deposits. In addition, the feasibility of uPAR-guided robotic cancer surgery was demonstrated. Also, uPAR-PET imaging showed a clear and localized signal in the tongue tumors. CONCLUSIONS: This study demonstrated...

  6. Supramolecular PEGylated Dendritic Systems as pH/Redox Dual-Responsive Theranostic Nanoplatforms for Platinum Drug Delivery and NIR Imaging.

    Science.gov (United States)

    Li, Yunkun; Li, Yachao; Zhang, Xiao; Xu, Xianghui; Zhang, Zhijun; Hu, Cheng; He, Yiyan; Gu, Zhongwei

    2016-01-01

    Recently, self-assembling small dendrimers into supramolecular dendritic systems offers an alternative strategy to develop multifunctional nanoplatforms for biomedical applications. We herein report a dual-responsive supramolecular PEGylated dendritic system for efficient platinum-based drug delivery and near-infrared (NIR) tracking. With a refined molecular/supramolecular engineering, supramolecular dendritic systems were stabilized by bioreducible disulfide bonds and endowed with NIR fluorescence probes, and PEGylated platinum derivatives coordinated onto the abundant peripheral groups of supramolecular dendritic templates to generate pH/redox dual-responsive theranostic supramolecular PEGylated dendritic systems (TSPDSs). TSPDSs markedly improved the pharmacokinetics and biodistribution of platinum-based drugs, owing to their stable nanostructures and PEGylated shells during the blood circulation. Tumor intracellular environment (low pH value and high glutathione concentration) could trigger the rapid disintegration of TSPDSs due to acid-labile coordination bonds and redox-cleavable disulfide linkages, and then platinum-based drugs were delivered into the nuclei to exert antitumor activity. In vivo antitumor treatments indicated TSPDSs not only provided high antitumor efficiency which was comparable to clinical cisplatin, but also reduced renal toxicity of platinum-based drugs. Moreover, NIR fluorescence of TSPDSs successfully visualized in vitro and in vivo fate of nanoplatforms and disclosed the intracellular platinum delivery and pharmacokinetics. These results confirm tailor-made supramolecular dendritic system with sophisticated nanostructure and excellent performance is a promising candidate as smart theranostic nanoplatforms.

  7. Real-time near-IR imaging of laser-ablation crater evolution in dental enamel

    Science.gov (United States)

    Darling, Cynthia L.; Fried, Daniel

    2007-02-01

    We have shown that the enamel of the tooth is almost completely transparent near 1310-nm in the near-infrared and that near-IR (NIR) imaging has considerable potential for the optical discrimination of sound and demineralized tissue and for observing defects in the interior of the tooth. Lasers are now routinely used for many applications in dentistry including the ablation of dental caries. The objective of this study was to test the hypothesis that real-time NIR imaging can be used to monitor laser-ablation under varying conditions to assess peripheral thermal and transient-stress induced damage and to measure the rate and efficiency of ablation. Moreover, NIR imaging may have considerable potential for monitoring the removal of demineralized areas of the tooth during cavity preparations. Sound human tooth sections of approximately 3-mm thickness were irradiated by a CO II laser under varying conditions with and without a water spray. The incision area in the interior of each sample was imaged using a tungsten-halogen lamp with band-pass filter centered at 131--nm combined with an InGaAs focal plane array with a NIR zoom microscope in transillumination. Due to the high transparency of enamel at 1310-nm, laser-incisions were clearly visible to the dentin-enamel junction and crack formation, dehydration and irreversible thermal changes were observed during ablation. This study showed that there is great potential for near-IR imaging to monitor laser-ablation events in real-time to: assess safe laser operating parameters by imaging thermal and stress-induced damage, elaborate the mechanisms involved in ablation such as dehydration, and monitor the removal of demineralized enamel.

  8. Vis-NIR hyperspectral imaging and multivariate analysis for prediction of the moisture content and hardness of Pistachio kernels roasted in different conditions

    Directory of Open Access Journals (Sweden)

    T Mohammadi Moghaddam

    2015-09-01

    Full Text Available Introduction: Pistachio nut is one of the most delicious and nutritious nuts in the world and it is being used as a salted and roasted product or as an ingredient in snacks, ice cream, desserts, etc. (Maghsudi, 2010; Kashaninejad et al. 2006. Roasting is one of the most important food processes which provides useful attributes to the product. One of the objectives of nut roasting is to alter and significantly enhance the flavor, texture, color and appearance of the product (Ozdemir, 2001. In recent years, spectral imaging techniques (i.e. hyperspectral and multispectral imaging have emerged as powerful tools for safequality inspection of various agricultural commodities (Gowen et al., 2007. The objectives of this study were to apply reflectance hyperspectral imaging for non-destructive determination of moisture content and hardness of pistachio kernels roasted in different conditions. Materials and methods: Dried O’hadi pistachio nuts were supplied from a local market in Mashhad. Pistachio nuts were soaked in 5L of 20% salt solution for 20min (Goktas Seyhan, 2003. For roasting process, three temperatures (90, 120 and 150°C, three times (20, 35 and 50 min and three air velocities (0.5, 1.5 and 2.5 m s-1 were applied. The moisture content of pistachio kernels was measured in triplicate using oven drying (3 gr samples at 105 °C for 12 hours. Uniaxial compression test by a 35mm diameter plastic cylinder, was made on the pistachio kernels, which were mounted on a platform. Samples were compressed at a depth of 2mm and speed of 30 mm min-1. A hyperspectral imaging system in the Vis-NIR range (400-1000 nm was employed. The spectral pre-processing techniques: first derivative and second derivative, median filter, Savitzkye-Golay, wavelet, multiplicative scatter correction (MSC and standard normal variate transformation (SNV were used. To make models at PLSR and ANN methods, ParLeS software and Matlab R2009a were used, respectively. The coefficient

  9. Photoluminescence studies of single InGaAs quantum dots

    DEFF Research Database (Denmark)

    Leosson, Kristjan; Jensen, Jacob Riis; Hvam, Jørn Märcher

    1999-01-01

    Semiconductor quantum dots are considered a promising material system for future optical devices and quantum computers. We have studied the low-temperature photoluminescence properties of single InGaAs quantum dots embedded in GaAs. The high spatial resolution required for resolving single dots...... is obtained by exciting and detecting the photoluminescence through a microscope objective which is located inside the cryostat. Furthermore, e-beam lithography and mesa etching have been used to reduce the size of the detection area to a few hundred nanometers in diameter. These techniques allow us...

  10. Photoluminescence studies of single InGaAs quantum dots

    DEFF Research Database (Denmark)

    Leosson, Kristjan; Jensen, Jacob Riis; Hvam, Jørn Märcher

    1999-01-01

    Semiconductor quantum dots are considered a promising material system for future optical devices and quantum computers. We have studied the low-temperature photoluminescence properties of single InGaAs quantum dots embedded in GaAs. The high spatial resolution required for resolving single dots...... to resolve luminescence lines from individual quantum dots, revealing an atomic-like spectrum of sharp transition lines. A parameter of fundamental importance is the intrinsic linewidth of these transitions. Using high-resolution spectroscopy we have determined the linewidth and investigated its dependence...... on temperature, which gives information about how the exciton confined to the quantum dot interacts with the surrounding lattice....

  11. Numerical modeling of extended short wave infrared InGaAs focal plane arrays

    Science.gov (United States)

    Glasmann, Andreu; Wen, Hanqing; Bellotti, Enrico

    2016-05-01

    Indium gallium arsenide (In1-xGaxAs) is an ideal material choice for short wave infrared (SWIR) imaging due to its low dark current and excellent collection efficiency. By increasing the indium composition from 53% to 83%, it is possible to decrease the energy gap from 0.74 eV to 0.47 eV and consequently increase the cutoff wavelength from 1.7 μm to 2.63 μm for extended short wavelength (ESWIR) sensing. In this work, we apply our well-established numerical modeling methodology to the ESWIR InGaAs system to determine the intrinsic performance of pixel detectors. Furthermore, we investigate the effects of different buffer/cap materials. To accomplish this, we have developed composition-dependent models for In1-xGaxAs, In1-xAlxAs, and InAs1-y Py. Using a Green's function formalism, we calculate the intrinsic recombination coefficients (Auger, radiative) to model the diffusion-limited behavior of the absorbing layer under ideal conditions. Our simulations indicate that, for a given total thickness of the buffer and absorbing layer, structures utilizing a linearly graded small-gap InGaAs buffer will produce two orders of magnitude more dark current than those with a wide gap, such as InAlAs or InAsP. Furthermore, when compared with experimental results for ESWIR photodiodes and arrays, we estimate that there is still a 1.5x magnitude of reduction in dark current before reaching diffusion-limited behavior.

  12. Development of high performance SWIR InGaAs focal plane array

    Science.gov (United States)

    Nagi, Richie; Bregman, Jeremy; Mizuno, Genki; Oduor, Patrick; Olah, Robert; Dutta, Achyut K.; Dhar, Nibir K.

    2015-05-01

    Banpil Photonics has developed a novel InGaAs based photodetector array for Short-Wave Infrared (SWIR) imaging, for the most demanding security, defense, and machine vision applications. These applications require low noise from both the detector and the readout integrated circuit arrays. In order to achieve high sensitivity, it is crucial to minimize the dark current generated by the photodiode array. This enables the sensor to function in extremely low light situations, which enables it to successfully exploit the benefits of the SWIR band. In addition to minimal dark current generation, it is essential to develop photodiode arrays with higher operating temperatures. This is critical for reducing the power consumption of the device, as less energy is spent in cooling down the focal plane array (in order to reduce the dark current). We at Banpil Photonics are designing, simulating, fabricating and testing SWIR InGaAs arrays, and have achieved low dark current density at room temperature. This paper describes Banpil's development of the photodetector array. We also highlight the fabrication technique used to reduce the amount of dark current generated by the photodiode array, in particular the surface leakage current. This technique involves the deposition of strongly negatively doped semiconductor material in the area between the pixels. This process reduces the number of dangling bonds present on the edges of each pixel, which prevents electrons from being swept across the surface of the pixels. This in turn drastically reduces the amount of surface leakage current at each pixel, which is a major contributor towards the total dark current. We present the optical and electrical characterization data, as well as the analysis that illustrates the dark current mechanisms. Also highlighted are the challenges and potential opportunities for further reduction of dark current, while maintaining other parameters of the photodiode array, such as size, weight, temperature

  13. [NIR spectroscopy based on least square support vector machines for quality prediction of tomato juice].

    Science.gov (United States)

    Huang, Kang; Wang, Hui-jun; Xu, Hui-rong; Wang, Jian-ping; Ying, Yi-bin

    2009-04-01

    The application of least square support vector machines (LS-SVM) regression method based on statistics study theory to the analysis with near infrared (NIR) spectra of tomato juice was introduced in the present paper. In this method, LS-SVM was used for establishing model of spectral analysis, and was applied to predict the sugar contents (SC) and available acid (VA) in tomato juice samples. NIR transmission spectra of tomato juice were measured in the spectral range of 800-2,500 nm using InGaAs detector. The radial basis function (RBF) was adopted as a kernel function of LS-SVM. Sixty seven tomato juice samples were used as calibration set, and thirty three samples were used as validation set. The results of the method for sugar contents (SC) and available acid (VA) prediction were: a high correlation coefficient of 0.9903 and 0.9675, and a low root mean square error of prediction (RMSEP) of 0.0056 degree Brix and 0.0245, respectively. And compared to PLS and PCR methods, the performance of the LSSVM method was better. The results indicated that it was possible to built statistic models to quantify some common components in tomato juice using near-infrared (NIR) spectroscopy and least square support vector machines (LS-SVM) regression method as a nonlinear multivariate calibration procedure, and LS-SVM could be a rapid and accurate method for juice components determination based on NIR spectra.

  14. The simulation of localized surface plasmon and surface plasmon polariton in wire grid polarizer integrated on InP substrate for InGaAs sensor

    Directory of Open Access Journals (Sweden)

    Rui Wang

    2015-07-01

    Full Text Available We numerically demonstrate the integration of gold wire grid polarizer on InP substrate for InGaAs polarimetric imaging. The effective spectral range of wire grid polarizer has been designed in 0.8-3 μm according to InGaAs response waveband. The dips in TM transmission are observed due to surface plasmon (SPs significantly damaging polarization performance. To further understand the coupling mechanism between gold wire grid grating and InP, the different contributions of surface plasmon polariton (SPP and localized surface plasmon (LSP to the dips are analyzed. Both transmission and reflectance spectra are simulated at different grating periods and duty cycles by finite-different time-domain (FDTD method. LSP wavelength is located at around 1 μm and sensitive to the specific shape of metal wire. SPP presents higher resonance wavelength closely related to grating period. The simulations of electric field distribution show the same results.

  15. Lanthanide NIR luminescence for telecommunications, bioanalyses and solar energy conversion

    Institute of Scientific and Technical Information of China (English)

    Jean-Claude; G.; Bünzli; V.

    2010-01-01

    Present-day advanced technologies heavily rely on the exciting magnetic and spectroscopic properties of lanthanide ions. In particular, their ability to generate well-characterized and intense near-infrared (NIR) luminescence is exploited in any modern fiber-optic telecommunication network. In this feature article, we first summarize the whereabouts underlying the design of highly luminescent NIR molecular edifices and materials. We then focus on describing the main trends in three applications related to this spectral range: telecommunications, biosciences, and solar energy conversion. In telecommunications, efforts concentrate presently on getting easily processable polymer-based waveguide amplifiers. Upconversion nanophosphors emitting in the visible after NIR excitation are now ubiquitous in many bioanalyses while their application to bio-imaging is still in its early stages; however, highly sensitive NIR-NIR systems start to be at hand for both in vitro and in vivo imaging, as well as dual probes combining magnetic resonance and optical imaging. Finally, both silicon-based and dye-sensitized solar cells benefit from the downconversion and upconversion capabilities of lanthanide ions to harvest UV and NIR solar light and to boost the overall quantum efficiency of these next-generation devices.

  16. The incidence of nirS and nirK and their genetic heterogeneity in cultivated denitrifiers.

    Science.gov (United States)

    Heylen, Kim; Gevers, Dirk; Vanparys, Bram; Wittebolle, Lieven; Geets, Joke; Boon, Nico; De Vos, Paul

    2006-11-01

    Gene sequence analysis of nirS and nirK, both encoding nitrite reductases, was performed on cultivated denitrifiers to assess their incidence in different bacterial taxa and their taxonomical value. Almost half of the 227 investigated denitrifying strains did not render an nir amplicon with any of five previously described primers. NirK and nirS were found to be prevalent in Alphaproteobacteria and Betaproteobacteria, respectively, nirK was detected in the Firmicutes and Bacteroidetes and nirS and nirK with equal frequency in the Gammaproteobacteria. These observations deviated from the hitherto reported incidence of nir genes in bacterial taxa. NirS gene phylogeny was congruent with the 16S rRNA gene phylogeny on family or genus level, although some strains did group within clusters of other bacterial classes. Phylogenetic nirK gene sequence analysis was incongruent with the 16S rRNA gene phylogeny. NirK sequences were also found to be significantly more similar to nirK sequences from the same habitat than to nirK sequences retrieved from highly related taxa. This study supports the hypothesis that horizontal gene transfer events of denitrification genes have occurred and underlines that denitrification genes should not be linked with organism diversity of denitrifiers in cultivation-independent studies.

  17. Multilayers of InGaAs Nanostructures Grown on GaAs(210 Substrates

    Directory of Open Access Journals (Sweden)

    Wang Zhiming

    2010-01-01

    Full Text Available Abstract Multilayers of InGaAs nanostructures are grown on GaAs(210 by molecular beam epitaxy. With reducing the thickness of GaAs interlayer spacer, a transition from InGaAs quantum dashes to arrow-like nanostructures is observed by atomic force microscopy. Photoluminescence measurements reveal all the samples of different spacers with good optical properties. By adjusting the InGaAs coverage, both one-dimensional and two-dimensional lateral ordering of InGaAs/GaAs(210 nanostructures are achieved.

  18. Dimensionality of InGaAs nonlinear optical response

    Energy Technology Data Exchange (ETDEWEB)

    Bolton, S.R. [Univ. of California, Berkeley, CA (United States). Dept. of Physics]|[Lawrence Berkeley National Lab., CA (United States). Materials Sciences Div.

    1995-07-01

    In this thesis the ultrafast optical properties of a series of InGaAs samples ranging from the two to the three dimensional limit are discussed. An optical system producing 150 fs continuum centered at 1.5 microns was built. Using this system, ultrafast pump-probe and four wave mixing experiments were performed. Carrier thermalization measurements reveal that screening of the Coulomb interaction is relatively unaffected by confinement, while Pauli blocking nonlinearities at the band edge are approximately twice as strong in two dimensions as in three. Carrier cooling via phonon emission is influenced by confinement due both to the change in electron distribution function and the reduction in electron phonon coupling. Purely coherent band edge effects, as measured by the AC Stark effect and four wave mixing, are found to be dominated by the changes in excitonic structure which take place with confinement.

  19. fNIRS-based online deception decoding

    Science.gov (United States)

    Hu, Xiao-Su; Hong, Keum-Shik; Ge, Shuzhi Sam

    2012-04-01

    Deception involves complex neural processes in the brain. Different techniques have been used to study and understand brain mechanisms during deception. Moreover, efforts have been made to develop schemes that can detect and differentiate deception and truth-telling. In this paper, a functional near-infrared spectroscopy (fNIRS)-based online brain deception decoding framework is developed. Deploying dual-wavelength fNIRS, we interrogate 16 locations in the forehead when eight able-bodied adults perform deception and truth-telling scenarios separately. By combining preprocessed oxy-hemoglobin and deoxy-hemoglobin signals, we develop subject-specific classifiers using the support vector machine. Deception and truth-telling states are classified correctly in seven out of eight subjects. A control experiment is also conducted to verify the deception-related hemodynamic response. The average classification accuracy is over 83.44% from these seven subjects. The obtained result suggests that the applicability of fNIRS as a brain imaging technique for online deception detection is very promising.

  20. NIR light propagation in a digital head model for traumatic brain injury (TBI).

    Science.gov (United States)

    Francis, Robert; Khan, Bilal; Alexandrakis, George; Florence, James; MacFarlane, Duncan

    2015-09-01

    Near infrared spectroscopy (NIRS) is capable of detecting and monitoring acute changes in cerebral blood volume and oxygenation associated with traumatic brain injury (TBI). Wavelength selection, source-detector separation, optode density, and detector sensitivity are key design parameters that determine the imaging depth, chromophore separability, and, ultimately, clinical usefulness of a NIRS instrument. We present simulation results of NIR light propagation in a digital head model as it relates to the ability to detect intracranial hematomas and monitor the peri-hematomal tissue viability. These results inform NIRS instrument design specific to TBI diagnosis and monitoring.

  1. Polyethylene glycol (PEG) linked to near infrared (NIR) dyes conjugated to chimeric anti-carcinoembryonic antigen (CEA) antibody enhances imaging of liver metastases in a nude-mouse model of human colon cancer.

    Science.gov (United States)

    Maawy, Ali A; Hiroshima, Yukihiko; Zhang, Yong; Luiken, George A; Hoffman, Robert M; Bouvet, Michael

    2014-01-01

    We report here that polyethylene glycol (PEG) linked to near infrared dyes conjugated to chimeric mouse-human anti-carcinoembryonic antigen (CEA) antibody greatly improves imaging of liver metastases in a nude mouse model of colon-cancer experimental metastases. PEGylated and non-PEGylated DyLight 650 and 750 dyes were conjugated to the chimeric anti-CEA antibody. The dyes were initially injected intravenously into nude mice without tumors. Tissue biodistribution was determined by tissue sonication and analyzing tissue dye concentration profiles over time. PEGylated dyes had significantly lower accumulation in the liver (p = 0.03 for the 650 dyes; p = 0.002 for the 750 dyes) compared to non-PEGylated dyes. In an experimental liver metastasis model of HT-29 colon cancer, PEGylated dyes conjugated to the anti-CEA antibody showed good labeling of metastatic tumors with high contrast between normal and malignant tissue which was not possible with the non-PEGylated dyes since there was so much non-specific accumulation in the liver. PEGylation of the DyLight 650 and 750 NIR dyes significantly altered tissue biodistribution, allowing brighter tissue labeling, decreased accumulation in normal organs, particularly the liver. This enabled high fidelity and high contrast imaging of liver metastases.

  2. Polyethylene glycol (PEG linked to near infrared (NIR dyes conjugated to chimeric anti-carcinoembryonic antigen (CEA antibody enhances imaging of liver metastases in a nude-mouse model of human colon cancer.

    Directory of Open Access Journals (Sweden)

    Ali A Maawy

    Full Text Available We report here that polyethylene glycol (PEG linked to near infrared dyes conjugated to chimeric mouse-human anti-carcinoembryonic antigen (CEA antibody greatly improves imaging of liver metastases in a nude mouse model of colon-cancer experimental metastases. PEGylated and non-PEGylated DyLight 650 and 750 dyes were conjugated to the chimeric anti-CEA antibody. The dyes were initially injected intravenously into nude mice without tumors. Tissue biodistribution was determined by tissue sonication and analyzing tissue dye concentration profiles over time. PEGylated dyes had significantly lower accumulation in the liver (p = 0.03 for the 650 dyes; p = 0.002 for the 750 dyes compared to non-PEGylated dyes. In an experimental liver metastasis model of HT-29 colon cancer, PEGylated dyes conjugated to the anti-CEA antibody showed good labeling of metastatic tumors with high contrast between normal and malignant tissue which was not possible with the non-PEGylated dyes since there was so much non-specific accumulation in the liver. PEGylation of the DyLight 650 and 750 NIR dyes significantly altered tissue biodistribution, allowing brighter tissue labeling, decreased accumulation in normal organs, particularly the liver. This enabled high fidelity and high contrast imaging of liver metastases.

  3. Intracellular Disassembly of Self-Quenched Nanoparticles Turns NIR Fluorescence on for Sensing Furin Activity in Cells and in Tumors.

    Science.gov (United States)

    Yuan, Yue; Zhang, Jia; Cao, Qinjingwen; An, Linna; Liang, Gaolin

    2015-06-16

    There has been no report on enzyme-controlled disassembly of self-quenched NIR fluorescent nanoparticles turning fluorescence on for specific detection/imaging of the enzyme's activity in vitro and in vivo. Herein, we reported the rational design of new NIR probe 1 whose fluorescence signal was self-quenched upon reduction-controlled condensation and subsequent assembly of its nanoparticles (i.e., 1-NPs). Then disassembly of 1-NPs by furin turned the fluorescence on. Employing this enzymatic strategy, we successfully applied 1-NPs for NIR detection of furin in vitro and NIR imaging furin activity in living cells. Moreover, we also applied 1-NPs for discriminative NIR imaging of MDA-MB-468 tumors in nude mice. This NIR probe 1 might be further developed for tumor-targeted imaging in routine preclinical studies or even in patients in the future.

  4. Online process analysis by NIRS; Online Prozessanalyse mit NIRS

    Energy Technology Data Exchange (ETDEWEB)

    Andree, Helga [TENIRS GmbH, Kiel (Germany)

    2009-07-01

    Nearinfrared-spectroscopy (NIRS) is a quick optical measurement system. It is meanwhile state of the art in many laboratory applications, such as feed analysis. Beyond that, NIRS is well suited as a multivariate inline-analysis-system for in-situ process-monitoring in biogas plants. First TENIRS pilot applications in full scale biogas plants deliver continuously DM, ODM, acetic-acid-equivalent, buffer-capacity, pH, ammonium and nitrogen. Advantages of NIRS as an integrated process-analysis-system derive from the contact-less, permanent measurement directly in the sample-stream, which allows representative complete monitoring of the entire process, simultaneous measurement of a wide range of parameters and the concurrent monitoring of multiple substrate streams. (orig.)

  5. Hemodynamic signals in fNIRS.

    Science.gov (United States)

    Hoshi, Y

    Near-infrared spectroscopy (NIRS) was originally designed for clinical monitoring of tissue oxygenation, and it has also been developed into a useful tool in neuroimaging studies, with the so-called functional NIRS (fNIRS). With NIRS, cerebral activation is detected by measuring the cerebral hemoglobin (Hb), where however, the precise correlation between NIRS signal and neural activity remains to be fully understood. This can in part be attributed to the situation that NIRS signals are inherently subject to contamination by signals arising from extracerebral tissue. In recent years, several approaches have been investigated to distinguish between NIRS signals originating in cerebral tissue and signals originating in extracerebral tissue. Selective measurements of cerebral Hb will enable a further evolution of fNIRS. This chapter is divided into six sections: first a summary of the basic theory of NIRS, NIRS signals arising in the activated areas, correlations between NIRS signals and fMRI signals, correlations between NIRS signals and neural activities, and the influence of a variety of extracerebral tissue on NIRS signals and approaches to this issue are reviewed. Finally, future prospects of fNIRS are described. © 2016 Elsevier B.V. All rights reserved.

  6. Magnetic and fluorescent Gd2O3:Yb3+/Ln3+ nanoparticles for simultaneous upconversion luminescence/MR dual modal imaging and NIR-induced photodynamic therapy

    OpenAIRE

    LIU Jun; Huang, Long; Tian, Xiumei; Chen, Xiaoming; Shao, Yuanzhi; Xie, Fukang; Chen, Dihu; Li, Li

    2016-01-01

    The development of upconversion nanoparticles (UCNs) for theranostics application is a new strategy toward the accurate diagnosis and efficient treatment of cancer. Here, magnetic and fluorescent lanthanide-doped gadolinium oxide (Gd2O3) UCNs with bright upconversion luminescence (UCL) and high longitudinal relaxivity (r 1) are used for simultaneous magnetic resonance imaging (MRI)/UCL dual-modal imaging and photodynamic therapy (PDT). In vitro and in vivo MRI studies show that these products...

  7. Reconstruction of original indium distribution in InGaAs quantum wells from experimental SIMS depth profiles

    Energy Technology Data Exchange (ETDEWEB)

    Kudriavtsev, Yu., E-mail: yuriyk@cinvestav.mx [Departamento Ingeniería Eléctrica – SEES, CINVESTAV-IPN, Av. IPN #2508, D.F., México (Mexico); Asomoza, R. [Departamento Ingeniería Eléctrica – SEES, CINVESTAV-IPN, Av. IPN #2508, D.F., México (Mexico); Gallardo-Hernandez, S.; Ramirez-Lopez, M.; Lopez-Lopez, M. [Departamento de Física, CINVESTAV-IPN, México (Mexico); Nevedomsky, V.; Moiseev, K. [Ioffe Physical Technical Institute, S-Petersburg (Russian Federation)

    2014-11-15

    Depth profiling analysis of InGaAs/GaAs hetero-structures grown by MBE on GaAs (0 0 1) substrates is reported. A novel two-step procedure for de-convolving experimental SIMS depth distribution is employed and the original In distribution in InGaAs quantum wells (QW) is estimated. The QW thickness calculated from the de-convolved profiles is shown to be in good agreement with the cross-sectional TEM images. The experimental In depth profile is shifted from the original In distribution due to the ion mixing process during depth profiling analysis. It is shown that the de-convolution procedure is suitable for reconstruction of the original QW width and depth by SIMS even for relatively high primary ion energies.

  8. InGaAs Schottky barrier diode array detector for a real-time compact terahertz line scanner.

    Science.gov (United States)

    Han, Sang-Pil; Ko, Hyunsung; Park, Jeong-Woo; Kim, Namje; Yoon, Young-Jong; Shin, Jun-Hwan; Kim, Dae Yong; Lee, Dong Hun; Park, Kyung Hyun

    2013-11-04

    We present a terahertz (THz) broadband antenna-integrated 1 × 20 InGaAs Schottky barrier diode (SBD) array detector with an average responsivity of 98.5 V/W at a frequency of 250 GHz, which is measured without attaching external amplifiers and Si lenses, and an average noise equivalent power (NEP) of 106.6 pW/√Hz. The 3-dB bandwidth of the SBD detector is also investigated at approximately 180 GHz. For implementing an array-type SBD detector by a simple fabrication process to achieve a high yield, a structure comprising an SiN(x) layer instead of an air bridge between the anode and the cathode is designed. THz line beam imaging using a Gunn diode emitter with a center frequency of 250 GHz and a 1 × 20 SBD array detector is successfully demonstrated.

  9. TROPOMI and TROPI: UV/VIS/NIR/SWIR instruments

    NARCIS (Netherlands)

    Levelt, P.F.; Oord, G.H.J. van den; Dobber, M.; Eskes, H.; Weele, M. van; Veefkind, P.; Oss, R. van; Aben, I.; Jongma, R.T.; Landgraf, J.; Vries, J. de; Visser, H.

    2006-01-01

    TROPOMI (Tropospheric Ozone-Monitoring Instrument) is a five-channel UV-VIS-NIR-SWIR non-scanning nadir viewing imaging spectrometer that combines a wide swath (114°) with high spatial resolution (10 × 10 km 2). The instrument heritage consists of GOME on ERS-2, SCIAMACHY on Envisat and, especially,

  10. TROPOMI and TROPI: UV/VIS/NIR/SWIR instruments

    NARCIS (Netherlands)

    Levelt, P.F.; Oord, G.H.J. van den; Dobber, M.; Eskes, H.; Weele, M. van; Veefkind, P.; Oss, R. van; Aben, I.; Jongma, R.T.; Landgraf, J.; Vries, J. de; Visser, H.

    2006-01-01

    TROPOMI (Tropospheric Ozone-Monitoring Instrument) is a five-channel UV-VIS-NIR-SWIR non-scanning nadir viewing imaging spectrometer that combines a wide swath (114°) with high spatial resolution (10 × 10 km 2). The instrument heritage consists of GOME on ERS-2, SCIAMACHY on Envisat and, especially,

  11. Transmission electron microscopy and photoluminescence characterization of InGaAs strained quantum wires on GaAs vicinal (110) substrates

    CERN Document Server

    Shim, B R; Ota, T; Kobayashi, K; Maehashi, K; Nakashima, H; Lee, S Y

    1999-01-01

    We have used transmission electron microscopy (TEM) and photoluminescence (PL) to study InGaAs/AlGaAs strained quantum wires (QWRs) grown by molecular beam epitaxy (MBE) on GaAs vicinal (110) substrates. The cross-sectional TEM image reveals that InGaAs QWRs structures are naturally formed on AlGaAs giant steps. In the plan-view TEM images, the fringe pattern in the giant-step region is observed for In sub x Ga sub 1 sub - sub x As layers with x<= 0.4 We measured the separation of the fringe in the plan-view TEM images and compared the result with the calculated fringe separation. From this result, we conclude that the fringes observed in the plan-view TEM images are moire fringes. PL spectra of the InGaAs QWRs samples reveal 80-meV shifts to lower energy with respect to the spectrum of a quantum well (QWL) grown on a (001) substrate under the same conditions. We also measured the polarization anisotropy of the PL spectra from the QWRs. The PL peak shifts systematically toward higher energy with decreasing...

  12. Magnetic and fluorescent Gd2O3:Yb(3+)/Ln(3+) nanoparticles for simultaneous upconversion luminescence/MR dual modal imaging and NIR-induced photodynamic therapy.

    Science.gov (United States)

    Liu, Jun; Huang, Long; Tian, Xiumei; Chen, Xiaoming; Shao, Yuanzhi; Xie, Fukang; Chen, Dihu; Li, Li

    The development of upconversion nanoparticles (UCNs) for theranostics application is a new strategy toward the accurate diagnosis and efficient treatment of cancer. Here, magnetic and fluorescent lanthanide-doped gadolinium oxide (Gd2O3) UCNs with bright upconversion luminescence (UCL) and high longitudinal relaxivity (r1) are used for simultaneous magnetic resonance imaging (MRI)/UCL dual-modal imaging and photodynamic therapy (PDT). In vitro and in vivo MRI studies show that these products can serve as good MRI contrast agents. The bright upconversion luminescence of the products allows their use as fluorescence nanoprobes for live cells imaging. We also utilized the luminescence-emission capability of the UCNs for the activation of a photosensitizer to achieve significant PDT results. To the best of our knowledge, this study is the first use of lanthanide-doped Gd2O3 UCNs in a theranostics application. This investigation provides a useful platform for the development of Gd2O3-based UCNs for clinical diagnosis, treatment, and imaging-guided therapy of cancer.

  13. Magnetic and fluorescent Gd2O3:Yb3+/Ln3+ nanoparticles for simultaneous upconversion luminescence/MR dual modal imaging and NIR-induced photodynamic therapy

    Science.gov (United States)

    Liu, Jun; Huang, Long; Tian, Xiumei; Chen, Xiaoming; Shao, Yuanzhi; Xie, Fukang; Chen, Dihu; Li, Li

    2017-01-01

    The development of upconversion nanoparticles (UCNs) for theranostics application is a new strategy toward the accurate diagnosis and efficient treatment of cancer. Here, magnetic and fluorescent lanthanide-doped gadolinium oxide (Gd2O3) UCNs with bright upconversion luminescence (UCL) and high longitudinal relaxivity (r1) are used for simultaneous magnetic resonance imaging (MRI)/UCL dual-modal imaging and photodynamic therapy (PDT). In vitro and in vivo MRI studies show that these products can serve as good MRI contrast agents. The bright upconversion luminescence of the products allows their use as fluorescence nanoprobes for live cells imaging. We also utilized the luminescence-emission capability of the UCNs for the activation of a photosensitizer to achieve significant PDT results. To the best of our knowledge, this study is the first use of lanthanide-doped Gd2O3 UCNs in a theranostics application. This investigation provides a useful platform for the development of Gd2O3-based UCNs for clinical diagnosis, treatment, and imaging-guided therapy of cancer. PMID:28031709

  14. Dual mode NIR long persistent phosphorescence and NIR-to-NIR Stokes luminescence in La{sub 3}Ga{sub 5}GeO{sub 14}: Cr{sup 3+}, Nd{sup 3+} phosphor

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Yiling; Li, Yang, E-mail: msliyang@scut.edu.cn; Qin, Xixi; Chen, Ruchun; Wu, Dakun; Liu, Shijian; Qiu, Jianrong, E-mail: qjr@scut.edu.cn

    2015-11-15

    Recently, long persistent phosphors (LPPs) have been considered to be the most prominent candidates for biomedical applications. However, the LPPs suffer from a dramatic decrease in luminescence intensity after incorporation into the tissue. Therefore, it is very necessary to develop the more competitive LPPs and acquire the reproducible tissue imaging. Here, we propose and experimentally demonstrate an effective bifunctional La{sub 3}Ga{sub 5}GeO{sub 14}: Cr{sup 3+}, Nd{sup 3+} phosphor with the interesting characteristic of near-infrared long persistent phosphorescence and NIR-to-NIR Stokes luminescence. Cr{sup 3+} and Nd{sup 3+} ions are simultaneously selected as the emission centers in order to take advantage of the remarkable phosphorescence properties of Cr{sup 3+}, and the appropriate energy level characteristic of NIR-excitation band (808 nm) and NIR-emission (1064 nm), and the ability as the brilliant auxiliary to create more efficient defects of Nd{sup 3+}. The efficient dual-modal emission is, accordingly utilized to realize the convenient, high-resolution global detection and local imaging. - Highlights: • Dual mode phosphor with NIR long afterglow and NIR-to-NIR Stokes luminescence. • Increasing the persistent duration due to the codoping of Nd. • Avoiding the noteworthy overheating effect due to the strong absorption at 980 nm.

  15. UAS-based soil carbon mapping using VIS-NIR (480–1000 nm) multi-spectral imaging: Potential and limitations

    DEFF Research Database (Denmark)

    Aldana Jague, Emilien; Heckrath, Goswin; Macdonald, Andy

    2016-01-01

    Traditional methods to assess the soil organic carbon (SOC) content based on soil sampling and analysis are time consuming and expensive, and the results are influenced by the sampling design. The aim of this study was to investigate the potential of UAS (Unmanned Aerial Systems) multi-spectral i......Traditional methods to assess the soil organic carbon (SOC) content based on soil sampling and analysis are time consuming and expensive, and the results are influenced by the sampling design. The aim of this study was to investigate the potential of UAS (Unmanned Aerial Systems) multi...... practices, provide a valuable resource to evaluate this approach. We acquired images (wavelength: 480–550–670–780–880–1000 nm) at an altitude of 120 m over an area of 2 ha using a multi-spectral camera mounted on an UAS. The high-resolution images captured smallscale variations at the soil surface (e...

  16. Magnetic and fluorescent Gd2O3:Yb3+/Ln3+ nanoparticles for simultaneous upconversion luminescence/MR dual modal imaging and NIR-induced photodynamic therapy

    OpenAIRE

    Liu J.; Huang L; Tian XM; Chen XM; Shao YZ; Xie FK; Chen DH; Li L.

    2016-01-01

    Jun Liu,1,* Long Huang,2,3,* Xiumei Tian,4 Xiaoming Chen,4 Yuanzhi Shao,5 Fukang Xie,3 Dihu Chen,1 Li Li21School of Electronics and Information Technology and School of Physics, 2State Key Laboratory of Oncology in South China, Imaging Diagnosis and Interventional Center, 3Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-Sen University, 4Department of Biomedical Engineering, Guangzhou Medical University, 5State Key Laboratory of Optoelectronic Materials and Techno...

  17. Terahertz Generation Using Implanted InGaAs Photomixers and Multi-wavelength Quantum Dot Lasers

    Institute of Scientific and Technical Information of China (English)

    Y Hou; J R Liu; M Buchanan; A J Spring Thorpe; P J Poole; H C Liu; Ke Wu; Sjoerd Roorda; X P Zhang

    2012-01-01

    We report on a study of terahertz (THz) generation using implanted InGaAs photomixers and multi-wavelength quantum dot lasers. We carry out InGaAs materials growth, optical characterization, device design and fabrication, and photomixing experiments. This approach is capable of generating a comb of electromagnetic radiation from microwave to terahertz. For shortening photomixer carrier lifetime, we employ proton implantation into an epitaxial layer of lattice matched InGaAs grown on InP. Under a 1.55 µm multi-mode InGaAs/InGaAsP quantum dot laser excitation, a frequency comb with a constant frequency spacing of 50 GHz generated on the photomixer is measured, which corresponds to the beats of the laser longitudinal modes. The measurement is performed with a Fourier transform infrared spectrometer. This approach affords a convenient method to achieve a broadband multi-peak coherent THz source.

  18. Taking NIRS to the field

    Science.gov (United States)

    Forage nutritive value (i.e., forage quality) impacts livestock health and performance, but determining the quality of forages for grazing animals is difficult. In the 1970s, development and application of bench-top near-infrared spectroscopy (NIRS) techniques to assess forage quality proved to be ...

  19. A career in agriculture and NIR

    Science.gov (United States)

    Having spent the last three decades in research and most of that dealing with the application of near-infrared (NIR) spectroscopy (NIRS) to animal agriculture has led to observations about NRS in general and career decisions in particular. For example, over the last two decades NIRS has moved from ...

  20. Enhancement of spin lifetime in gate-fitted InGaAs narrow wires.

    Science.gov (United States)

    Kunihashi, Yoji; Kohda, Makoto; Nitta, Junsaku

    2009-06-05

    We investigated the spin lifetime in gate-fitted InGaAs narrow wires from magnetotransport measurement. Applying positive gate bias voltage, the spin lifetimes in narrow wires became more than one order longer than those obtained from a Hall bar sample with two-dimensional electron gas. This enhancement of spin lifetime in gated wires is the first experimental evidence of dimensional confinement and resonant spin-orbit interaction effect controlled by gate bias voltage. Spin relaxation due to the cubic Dresselhaus term is negligible in the present InGaAs wires.

  1. Properties of InGaAs quantum dot saturable absorbers in monolithic mode-locked lasers

    DEFF Research Database (Denmark)

    Thompson, M.G.; Marinelli, C.; Chu, Y.

    Saturable absorbers properties are characterised in monolithic mode-locked InGaAs quantum dot lasers. We analyse the impact of weak quantum confined Stark effect, fast absorber recovery time and low absorber saturation power on the mode-locking performance.......Saturable absorbers properties are characterised in monolithic mode-locked InGaAs quantum dot lasers. We analyse the impact of weak quantum confined Stark effect, fast absorber recovery time and low absorber saturation power on the mode-locking performance....

  2. Spatial modelling of organic carbon in burned mountain soils using hyperspectral images, field datasets and NiR spectroscopy (Cantabrian Range; NW Spain)

    Science.gov (United States)

    Fernández, Susana; Peón, Juanjose; Recondo, Carmen; Calleja, Javier

    2014-05-01

    In the North-West of the Cantabrian Range (north of Spain) the climate is oceanic and vegetation cover is continuous. Nevertheless, in the western part of the territory fires are very common, although small in size; their recurrence affects severely to soil properties. Soil organic matter is seriously affected by fires and suffers changes in stock, composition and distribution. In former researches stocks of oxidizable organic carbon increases in these burnt soils (32 Mg/ha in non-burned in front of 90 Mg/ha of oxidizable carbon measured in burned forest soils); however, biochart compounds, which are typically produced by fires, have not been found in all the fire-affected soils. In order to perfect a cartographic technique to identify areas with increases in soil carbon stocks caused by historical fire management we try to test a technique to transfer spectral calibrated model of soil organic carbon to hyperspectral images (AHS sensor). Total (TOC) and oxidizable carbon (OC) were measured in a population of 89 soil samples. OC mean was 19, 48 with STD 10,32. The samples were scanning with VNIR-SWIR spectrometer (350-2500nm) and chemometric model of OC was calibrated with very high level of adjust (R2 0,85) using Unscrambler 10.3. In order to transfer the chemiometric model to the hyperspectral images the model was recalculated using only the wavelengths present in the hyperspectral images (AHS sensor with cannels in 0,43-1,03;1,55-1,75;1,99-2,54 and 3,3-5,4nm of wavelengths). The most highlighting result was the increase in the adjust of model (R2 0,89) when the wavelengths were restricted between 2200 to 2400 nm. The model was regionalized to a large area using Arc Map 10 and crossing validate with RMSE 10. Finally, in order to analyze the influence of the relief in the OC landscape pattern the slope steepness was considered. Digital Terrain Model with 10m of resolution was used. Those areas with long, steep hillsides covered with heaths have lower amounts of OC

  3. [Potential Applicability of Fecal NIRs: A Review].

    Science.gov (United States)

    Yan, Xu; Du, Zhou-he; Bai, Shi-qie; Zuo, Yan-chun; Zhou, Xiao-kang; Kou, Jing; Yan, Jia-jun; Zhang, Jian-bo; Li, Ping; You, Ming-hong; Zhang, Yu; Li, Da-xu; Zhang, Chang-bing; Zhang, Jin

    2015-12-01

    Near-infrared reflectance spectroscopy (NIRS) is an inexpensive, rapid, environment-friendly and non-invasive analytical technique that has been extensively applied in the analysis of the dietary attributes and the animal products. Acquisition of dietary attributes is essential for nutritional diagnoses to provide animals with reasonable diet. Traditionally, the calibration equations for the prediction of dietary attributes (e. g. crude protein) are developed from feed NIR spectra and the results of conventional chemical analysis (i. e. reference data). It is difficult to obtain the NIR spectra of forages consumed by grazing animals, so the method of this calibration is inappropriate for free-grazing herbivores. Feces, as the animal's metabolites, contain the information about both the animal's diet and the animal itself. Recently, Fecal-NIRS (F. NIRS) has been directly used to monitor diet information (botanical composition, chemical composition and digestibility), based on correlation between reference data and fecal NIR profile. Subsequently, some additional application (such as sex and species discrimination, reproductive and parasite status) of F. NIRS also is outlined. In the last, application of NIRS in animal manure is summarized. NIRS was shown to be an alternative to conventional wet chemical methods for analyzing some nutrient concentrations in animal manure rapidly. Overall, this paper proves that F. NIRS is a rapid and valid tool for the determination of the dietary attributes and of the physiological status of animal, although more efforts need to be done to improve the accuracy of the F. NIRS technique. Several researchers in English have reviewed the applications of F. NIRS. In China, however, there is a paucity of research and application regarding F. NIRS. We expect that this paper in Chinese will be helpful to the development of F. NIRS in China. At the same time, we propose NIRS as a simple and rapid analytical method for predicting the main

  4. Predicting Gilthead Sea Bream (Sparus aurata Freshness by a Novel Combined Technique of 3D Imaging and SW-NIR Spectral Analysis

    Directory of Open Access Journals (Sweden)

    Eugenio Ivorra

    2016-10-01

    Full Text Available A technique that combines the spatial resolution of a 3D structured-light (SL imaging system with the spectral analysis of a hyperspectral short-wave near infrared system was developed for freshness predictions of gilthead sea bream on the first storage days (Days 0–6. This novel approach allows the hyperspectral analysis of very specific fish areas, which provides more information for freshness estimations. The SL system obtains a 3D reconstruction of fish, and an automatic method locates gilthead’s pupils and irises. Once these regions are positioned, the hyperspectral camera acquires spectral information and a multivariate statistical study is done. The best region is the pupil with an R2 of 0.92 and an RMSE of 0.651 for predictions. We conclude that the combination of 3D technology with the hyperspectral analysis offers plenty of potential and is a very promising technique to non destructively predict gilthead freshness.

  5. A stochastic ensemble-based model to predict crop water requirements from numerical weather forecasts and VIS-NIR high resolution satellite images in Southern Italy

    Science.gov (United States)

    Pelosi, Anna; Falanga Bolognesi, Salvatore; De Michele, Carlo; Medina Gonzalez, Hanoi; Villani, Paolo; D'Urso, Guido; Battista Chirico, Giovanni

    2015-04-01

    Irrigation agriculture is one the biggest consumer of water in Europe, especially in southern regions, where it accounts for up to 70% of the total water consumption. The EU Common Agricultural Policy, combined with the Water Framework Directive, imposes to farmers and irrigation managers a substantial increase of the efficiency in the use of water in agriculture for the next decade. Ensemble numerical weather predictions can be valuable data for developing operational advisory irrigation services. We propose a stochastic ensemble-based model providing spatial and temporal estimates of crop water requirements, implemented within an advisory service offering detailed maps of irrigation water requirements and crop water consumption estimates, to be used by water irrigation managers and farmers. The stochastic model combines estimates of crop potential evapotranspiration retrieved from ensemble numerical weather forecasts (COSMO-LEPS, 16 members, 7 km resolution) and canopy parameters (LAI, albedo, fractional vegetation cover) derived from high resolution satellite images in the visible and near infrared wavelengths. The service provides users with daily estimates of crop water requirements for lead times up to five days. The temporal evolution of the crop potential evapotranspiration is simulated with autoregressive models. An ensemble Kalman filter is employed for updating model states by assimilating both ground based meteorological variables (where available) and numerical weather forecasts. The model has been applied in Campania region (Southern Italy), where a satellite assisted irrigation advisory service has been operating since 2006. This work presents the results of the system performance for one year of experimental service. The results suggest that the proposed model can be an effective support for a sustainable use and management of irrigation water, under conditions of water scarcity and drought. Since the evapotranspiration term represents a staple

  6. Folate/NIR 797-conjugated albumin magnetic nanospheres: synthesis, characterisation, and in vitro and in vivo targeting evaluation.

    Directory of Open Access Journals (Sweden)

    Qiusha Tang

    Full Text Available A practical and effective strategy for synthesis of Folate-NIR 797-conjugated Magnetic Albumin Nanospheres (FA-NIR 797-MAN was developed. For this strategy, Magnetic Albumin Nanospheres (MAN, composed of superparamagnetic iron oxide nanoparticles (SPIONs and bovine serum albumin (BSA, were covalently conjugated with folic acid (FA ligands to enhance the targeting capability of the particles to folate receptor (FR over-expressing tumours. Subsequently, a near-infrared (NIR fluorescent dye NIR 797 was conjugated with FA-conjugated MAN for in vivo fluorescence imaging. The FA-NIR 797-MAN exhibited low toxicity to a human nasopharyngeal epidermal carcinoma cell line (KB cells. Additionally, in vitro and in vivo evaluation of the dynamic behaviour and targeting ability of FA-NIR 797-MAN to KB tumours validated the highly selective affinity of FA-NIR 797-MAN for FR-positive tumours. In summary, the FA-NIR 797-MAN prepared here exhibited great potential for tumour imaging, since the near-infrared fluorescence contrast agents target cells via FR-mediated endocytosis. The high fluorescence intensity together with the targeting effect makes FA-NIR 797-MAN a promising candidate for imaging, monitoring, and early diagnosis of cancer at the molecular and cellular levels.

  7. Folate/NIR 797-conjugated albumin magnetic nanospheres: synthesis, characterisation, and in vitro and in vivo targeting evaluation.

    Science.gov (United States)

    Tang, Qiusha; An, Yanli; Liu, Dongfang; Liu, Peidang; Zhang, Dongsheng

    2014-01-01

    A practical and effective strategy for synthesis of Folate-NIR 797-conjugated Magnetic Albumin Nanospheres (FA-NIR 797-MAN) was developed. For this strategy, Magnetic Albumin Nanospheres (MAN), composed of superparamagnetic iron oxide nanoparticles (SPIONs) and bovine serum albumin (BSA), were covalently conjugated with folic acid (FA) ligands to enhance the targeting capability of the particles to folate receptor (FR) over-expressing tumours. Subsequently, a near-infrared (NIR) fluorescent dye NIR 797 was conjugated with FA-conjugated MAN for in vivo fluorescence imaging. The FA-NIR 797-MAN exhibited low toxicity to a human nasopharyngeal epidermal carcinoma cell line (KB cells). Additionally, in vitro and in vivo evaluation of the dynamic behaviour and targeting ability of FA-NIR 797-MAN to KB tumours validated the highly selective affinity of FA-NIR 797-MAN for FR-positive tumours. In summary, the FA-NIR 797-MAN prepared here exhibited great potential for tumour imaging, since the near-infrared fluorescence contrast agents target cells via FR-mediated endocytosis. The high fluorescence intensity together with the targeting effect makes FA-NIR 797-MAN a promising candidate for imaging, monitoring, and early diagnosis of cancer at the molecular and cellular levels.

  8. PAT: From Western solid dosage forms to Chinese materia medica preparations using NIR-CI.

    Science.gov (United States)

    Zhou, Luwei; Xu, Manfei; Wu, Zhisheng; Shi, Xinyuan; Qiao, Yanjiang

    2016-01-01

    Near-infrared chemical imaging (NIR-CI) is an emerging technology that combines traditional near-infrared spectroscopy with chemical imaging. Therefore, NIR-CI can extract spectral information from pharmaceutical products and simultaneously visualize the spatial distribution of chemical components. The rapid and non-destructive features of NIR-CI make it an attractive process analytical technology (PAT) for identifying and monitoring critical control parameters during the pharmaceutical manufacturing process. This review mainly focuses on the pharmaceutical applications of NIR-CI in each unit operation during the manufacturing processes, from the Western solid dosage forms to the Chinese materia medica preparations. Finally, future applications of chemical imaging in the pharmaceutical industry are discussed.

  9. Spin injection from Co2MnGa into an InGaAs quantum well

    DEFF Research Database (Denmark)

    Hickey, M. C.; Damsgaard, Christian Danvad; Holmes, S. N.;

    2008-01-01

    We have demonstrated spin injection from a full Heusler alloy Co2MnGa thin film into a (100) InGaAs quantum well in a semiconductor light-emitting diode structure at a temperature of 5 K. The detection is performed in the oblique Hanle geometry, allowing quantification of the effective spin...

  10. Quantum efficiency and oscillator strength of site-controlled InGaAs quantum dots

    DEFF Research Database (Denmark)

    Albert, F.; Schneider, C.; Stobbe, Søren

    2010-01-01

    We report on time-resolved photoluminescence spectroscopy to determine the oscillator strength (OS) and the quantum efficiency (QE) of site-controlled In(Ga)As quantum dots nucleating on patterned nanoholes. These two quantities are determined by measurements on site-controlled quantum dot (SCQD.......1±2.6 and an encouragingly high QE of (48±14)% for the SCQDs....

  11. Quantum efficiency and oscillator strength of site-controlled InGaAs quantum dots

    DEFF Research Database (Denmark)

    Albert, F.; Schneider, C.; Stobbe, Søren;

    2010-01-01

    We report on time-resolved photoluminescence spectroscopy to determine the oscillator strength (OS) and the quantum efficiency (QE) of site-controlled In(Ga)As quantum dots nucleating on patterned nanoholes. These two quantities are determined by measurements on site-controlled quantum dot (SCQD...

  12. Cheetah: A high frame rate, high resolution SWIR image camera

    Science.gov (United States)

    Neys, Joel; Bentell, Jonas; O'Grady, Matt; Vermeiren, Jan; Colin, Thierry; Hooylaerts, Peter; Grietens, Bob

    2008-10-01

    A high resolution, high frame rate InGaAs based image sensor and associated camera has been developed. The sensor and the camera are capable of recording and delivering more than 1700 full 640x512pixel frames per second. The FPA utilizes a low lag CTIA current integrator in each pixel, enabling integration times shorter than one microsecond. On-chip logics allows for four different sub windows to be read out simultaneously at even higher rates. The spectral sensitivity of the FPA is situated in the SWIR range [0.9-1.7 μm] and can be further extended into the Visible and NIR range. The Cheetah camera has max 16 GB of on-board memory to store the acquired images and transfer the data over a Gigabit Ethernet connection to the PC. The camera is also equipped with a full CameralinkTM interface to directly stream the data to a frame grabber or dedicated image processing unit. The Cheetah camera is completely under software control.

  13. FC-NIRS: A Functional Connectivity Analysis Tool for Near-Infrared Spectroscopy Data

    Directory of Open Access Journals (Sweden)

    Jingping Xu

    2015-01-01

    Full Text Available Functional near-infrared spectroscopy (fNIRS, a promising noninvasive imaging technique, has recently become an increasingly popular tool in resting-state brain functional connectivity (FC studies. However, the corresponding software packages for FC analysis are still lacking. To facilitate fNIRS-based human functional connectome studies, we developed a MATLAB software package called “functional connectivity analysis tool for near-infrared spectroscopy data” (FC-NIRS. This package includes the main functions of fNIRS data preprocessing, quality control, FC calculation, and network analysis. Because this software has a friendly graphical user interface (GUI, FC-NIRS allows researchers to perform data analysis in an easy, flexible, and quick way. Furthermore, FC-NIRS can accomplish batch processing during data processing and analysis, thereby greatly reducing the time cost of addressing a large number of datasets. Extensive experimental results using real human brain imaging confirm the viability of the toolbox. This novel toolbox is expected to substantially facilitate fNIRS-data-based human functional connectome studies.

  14. Using Massive Multivariate NIRS Data in Ryegrass

    DEFF Research Database (Denmark)

    Edriss, Vahid; Greve-Pedersen, Morten; Jensen, Christian S;

    Near infrared spectroscopy (NIRS) analytical techniques is a simple, fast and low cost method of high dimensional phenotyping compared to usual chemical techniques. To use this method there is no need for special sample preparation. The aim of this study is to use NIRS data to predict plant traits...... (e.g. dry matter, protein content, etc.) for the next generation. In total 1984 NIRS data from 995 ryegrass families (first cut) were used. The Absorption of radiation in the region of 960 – 1690 nm in every 2 nm distance produced 366 bins to represent the NIRS spectrum. The amount of genetic...

  15. Buckling of a single-layered graphene sheet on an initially strained InGaAs thin plate

    Energy Technology Data Exchange (ETDEWEB)

    Taziev, R M; Ya Prinz, V, E-mail: taziev@thermo.isp.nsc.ru [Institute of Semiconductor Physics, 630090, Novosibirsk (Russian Federation)

    2011-07-29

    The elastic buckling behavior of a defect-free single-layered graphene sheet deposited on a strained InGaAs substrate is investigated. Such a buckled sandwich structure can be formed by local etching of an initially strained InGaAs substrate. We numerically investigated the necessary buckling conditions for a single-layered graphene sheet of circular geometry on an initially strained InGaAs thin plate. A criterion for buckling for various axisymmetric buckling shapes was obtained. It is shown that for a thin circular InGaAs plate with a monolayer graphene sheet of radius 80 nm and thickness 4 nm three axisymmetric buckling shapes can be obtained. For an initial value of the elastic deformation of the plate of 3%, the in-plane strain in graphene can reach a value of 1%. This deformation is shown to be distributed inhomogeneously along the radius of the graphene monolayer.

  16. Characterization of Mind Wandering using fNIRS

    Directory of Open Access Journals (Sweden)

    Gautier eDurantin

    2015-03-01

    Full Text Available Assessing whether someone is attending to a task has become importantfor educational and professional applications. Such attentional drifts are usually termed mind wandering. The purpose of the current study is to test to what extent a recent neural imaging modality can be used to detect mind wandering episodes. Functional near infra-red spectroscopy is a non-invasive neuro-imaging technique that has never been studied so far to measure mind wandering. The Sustained Attention to Response Task was used to assess when subjects attention leaves a primary task. 16-channel fNIRS data were collected over frontal cortices. We observed significant activations over the medial prefrontal cortex during mind wandering, a brain region associated with the default mode network. fNIRS data were used to classify mind wandering data above chance level. In line with previous brain-imaging studies of mind wandering, our results confirm the ability of fNIRS to detect Default Network activations in the context of mind wandering.

  17. Measurement of 3-dimensional dopant distribution in InGaAs microdiscs grown selectively on Si (111)

    Science.gov (United States)

    Watanabe, Tohma; Takeuchi, Miyuki; Nakano, Yoshiaki; Sugiyama, Masakazu

    2017-04-01

    The control of the dopant profile in 3-dimentional InGaAs microdiscs on Si (111) is essential for their device applications. However, such profiles can never be controlled by simply changing the supply of dopant precursors during the growth of microdiscs. This is because a variety of crystal planes, such as (111), {-110}, and irregular planes near the corners, surround a hexagonal pillar of InGaAs and the incorporation efficiency of dopant elements depends significantly on the kind of planes involved. We here observed the distributions of sulfur and zinc in p-i-n InGaAs microdiscs by both cross-sectional scanning capacitance microscopy (SCM) and secondary-ion mass spectrometry using focused ion beam (NanoSIMS). Even though the InGaAs shell was grown on the microdiscs using dimethylzinc (DMZn), no p-type region was found on the top of the microdiscs and the p-type region existed on the sidewall of the discs alone. This result suggested that the zinc incorporation efficiency on InGaAs (111) plane is much lower than that on {-110} planes. Complete encapsulation of the microdiscs with p-type region was possible by the post-diffusion of zinc during exposure to a mixture of tertiarybutylarsine (TBAs) and DMZn after the growth of InGaAs microdiscs.

  18. A modified perpendicular drought index in NIR-Red reflectance space

    Science.gov (United States)

    Zhe, Li; Debao, Tan

    2014-03-01

    Soil moisture and vegetation index provides valuable information for surface water content and drought assessment with remotely sensed data. In this paper, a new drought monitoring method (MPDI1) with soil moisture and vegetation index is constructed in NIR-Red reflectance space. The relationship between MPDI1 and soil moisture is explored using satellite image and field measure data, and a comparison among MPDI1, the Perpendicular Drought Index (PDI), and the Modified Perpendicular Drought Index (MPDI) is also evaluated. Results indicate that the MPDI1 is highly accordant with the in-situ ground observation with the coefficient of determination (R2=0.4905) between MPDI1 and 5-20 cm mean soil moisture. Moreover, PDI, MPDI and MPDI1 provide quite similar spatial patterns for bare soil or lower vegetated surface, but MPDI1 demonstrates a better performance in measuring densely vegetated surface. This paper concludes that MPDI1 is a useful tool for surface drought estimation under complex underlying conditions.

  19. NIR fluorophore-hollow gold nanosphere complex for cancer enzyme-triggered detection and hyperthermia.

    Science.gov (United States)

    Wang, Jianting; Wheeler, Damon; Zhang, Jin Z; Achilefu, Samuel; Kang, Kyung A

    2013-01-01

    Hollow gold nanospheres (HGN) may be delicately tuned to absorb near infrared light (NIR) by tailoring the diameter-to-shell ratio. This unique property can be utilized for enhancing the contrast for the NIR and X-ray/CT imaging, and also noninvasive and local, photothermal hyperthermia by conjugating cancer-targeting molecules on the particle surface. In addition, when an NIR fluorophore is placed on the surface of the NIR-tuned HGNs, the fluorescence can be significantly quenched due to the emitted light absorption by the HGNs. Combining the NIR fluorescence quenching property of HGNs and the enzyme secreting nature of cancer, we have developed a novel enzyme-triggered NIR contrast agent for cancer detection with high specificity. NIR fluorophore Cypate (Indocyanine Green based) was conjugated to HGN via a short spacer for fluorescence quenching. The spacer contains an enzyme-substrate-motif (G-G-R) that can be cleaved by urokinase-type plasminogen activator (uPA, a breast cancer enzyme). The nano-complex normally does not emit fluorescence but, in the presence of uPA, the fluorescence was restored, providing high specificity. The enzyme-specific emission allows us to characterize the nature of the cancer (e.g., invasive, metastatic, etc.). Once the cancer is detected, the same HGNs can be used to deliver heat to the cancer site for cancer-specific hyperthermia.

  20. Greenhouse cooling by NIR-reflection

    NARCIS (Netherlands)

    Hemming, S.; Kempkes, F.; Braak, van der N.; Dueck, T.A.; Marissen, A.

    2007-01-01

    Wageningen UR investigated the potential of several NIR-filtering methods to be applied in horticulture. In this paper the analysis of the optical properties of available NIR-filtering materials is given including a calculation method to quantify the energy reduction under these materials and to est

  1. Using Massive Multivariate NIRS Data in Ryegrass

    DEFF Research Database (Denmark)

    Edriss, Vahid; Greve-Pedersen, Morten; Jensen, Christian S

    2015-01-01

    Near infrared spectroscopy (NIRS) analytical techniques is a simple, fast and low cost method of high dimensional phenotyping compared to usual chemical techniques. To use this method there is no need for special sample preparation. The aim of this study is to use NIRS data to predict plant traits...

  2. Structural and optical features of InGaAs quantum dots grown on Si(001) substrates

    Energy Technology Data Exchange (ETDEWEB)

    Vdovin, V I [Institute for Chemical Problems of Microelectronics, 119017 Moscow (Russian Federation); Kazakov, I P [PN Lebedev Physical Institute, Russian Academy of Sciences, 119991 Moscow (Russian Federation); Rzaev, M M [PN Lebedev Physical Institute, Russian Academy of Sciences, 119991 Moscow (Russian Federation); Burbaev, T M [PN Lebedev Physical Institute, Russian Academy of Sciences, 119991 Moscow (Russian Federation)

    2002-12-09

    A multilayer GaAs/SiGe/Si heterostructure with InGaAs quantum dots (QDs) embedded in a GaAs layer was grown by molecular beam epitaxy (MBE) on a Si(001) substrate. A step-graded Si{sub 1-x}Ge{sub x} (0 {<=} x {<=} 1) buffer layer and a GaAs layer with In{sub y}Ga{sub 1-y}As (y {approx} 0.5) QDs were deposited consecutively in two different MBE systems. The heterostructure exhibits intense photoluminescence in the region of 1.3 {mu}m at room temperature. Perfect crystal InGaAs islands with height less than 10 nm are the sources of this radiation.

  3. Temperature and Surface Traps Influence on the THz Emission from InGaAs Diodes

    Science.gov (United States)

    Rodriguez-Fernandez, A.; Íñiguez-de-la-Torre, I.; García-Pérez, Ó.; García, S.; Westlund, A.; Nilsson, P.-Å.; Grahn, J.; González, T.; Mateos, J.; Pérez, S.

    2015-10-01

    Monte Carlo simulations forecast Gunn-like oscillations at ∼0.75-1.25 THz in InGaAs planar recessed diodes (slot diodes); however, up to date no experimental evidence of this effect has been observed. The effects of temperature and surface charges on the emission parameters from InGaAs diodes are analyzed by means of an ensemble Monte Carlo simulator. Cooling the device down to 77 K strongly improves the amplitude of the oscillations and can increase their frequency. On the other hand, the ratio between cap and recess charges plays an important role for the onset of oscillations. A high level of traps in the recess region may completely attenuate the emission.

  4. Structural and optical features of InGaAs quantum dots grown on Si(001) substrates

    CERN Document Server

    Vdovin, V I; Rzaev, M M; Burbaev, T M

    2002-01-01

    A multilayer GaAs/SiGe/Si heterostructure with InGaAs quantum dots (QDs) embedded in a GaAs layer was grown by molecular beam epitaxy (MBE) on a Si(001) substrate. A step-graded Si sub 1 sub - sub x Ge sub x (0 <= x <= 1) buffer layer and a GaAs layer with In sub y Ga sub 1 sub sub - sub y As (y approx 0.5) QDs were deposited consecutively in two different MBE systems. The heterostructure exhibits intense photoluminescence in the region of 1.3 mu m at room temperature. Perfect crystal InGaAs islands with height less than 10 nm are the sources of this radiation.

  5. SHARK-NIR system design analysis overview

    Science.gov (United States)

    Viotto, Valentina; Farinato, Jacopo; Greggio, Davide; Vassallo, Daniele; Carolo, Elena; Baruffolo, Andrea; Bergomi, Maria; Carlotti, Alexis; De Pascale, Marco; D'Orazi, Valentina; Fantinel, Daniela; Magrin, Demetrio; Marafatto, Luca; Mohr, Lars; Ragazzoni, Roberto; Salasnich, Bernardo; Verinaud, Christophe

    2016-08-01

    In this paper, we present an overview of the System Design Analysis carried on for SHARK-NIR, the coronagraphic camera designed to take advantage of the outstanding performance that can be obtained with the FLAO facility at the LBT, in the near infrared regime. Born as a fast-track project, the system now foresees both coronagraphic direct imaging and spectroscopic observing mode, together with a first order wavefront correction tool. The analysis we here report includes several trade-offs for the selection of the baseline design, in terms of optical and mechanical engineering, and the choice of the coronagraphic techniques to be implemented, to satisfy both the main scientific drivers and the technical requirements set at the level of the telescope. Further care has been taken on the possible exploitation of the synergy with other LBT instrumentation, like LBTI. A set of system specifications is then flown down from the upper level requirements to finally ensure the fulfillment of the science drivers. The preliminary performance budgets are presented, both in terms of the main optical planes stability and of the image quality, including the contributions of the main error sources in different observing modes.

  6. Room temperature photoluminescence of InGaAs Surface Quantum Dots

    OpenAIRE

    Ulloa Herrero, José María; Yamamoto, K.; Fernández González, Alvaro de Guzmán; Hierro Cano, Adrián

    2011-01-01

    Self-assembled InGaAs quantum dots show unique physical properties such as three dimensional confinement, high size homogeneity, high density and low number of dislocations. They have been extensively used in the active regions of laser devices for optical communications applications [1]. Therefore, buried quantum dots (BQDs) embedded in wider band gap materials have been normally studied. The wave confinement in all directions and the stress field around the dot affect both optical and elect...

  7. Characterization of mind wandering using fNIRS.

    Science.gov (United States)

    Durantin, Gautier; Dehais, Frederic; Delorme, Arnaud

    2015-01-01

    Assessing whether someone is attending to a task has become important for educational and professional applications. Such attentional drifts are usually termed mind wandering (MW). The purpose of the current study is to test to what extent a recent neural imaging modality can be used to detect MW episodes. Functional near infrared spectroscopy is a non-invasive neuroimaging technique that has never been used so far to measure MW. We used the Sustained Attention to Response Task (SART) to assess when subjects attention leaves a primary task. Sixteen-channel fNIRS data were collected over frontal cortices. We observed significant activations over the medial prefrontal cortex (mPFC) during MW, a brain region associated with the default mode network (DMN). fNIRS data were used to classify MW data above chance level. In line with previous brain-imaging studies, our results confirm the ability of fNIRS to detect Default Network activations in the context of MW.

  8. Rapid Melt Growth of Single Crystal InGaAs on Si Substrates

    Directory of Open Access Journals (Sweden)

    Xue Bai

    2016-01-01

    Full Text Available InGaAs integration on Si substrates is an important topic for next generation electronic devices. Rapid melt growth (RMG has the potential to grow defect-free lattice mismatched materials on Si at low cost. Most previous publications have focused on growing binary III–V compounds by RMG, but none have discussed ternary compound materials. In this paper, we demonstrate the RMG of the single crystal ternary compound InGaAs on Si substrates. We discuss two main issues. The first is segregation along the stripe length. An analytical model is developed to describe the segregation of In/Ga in the grown stripe and the model is compared with experimental data. The second issue is the dissolution of the Si seed region during RMG, which leads to formation of Si islands inside the InGaAs stripe. The results of this study are applicable to any compound material in which Si is soluble at the elevated temperatures required for RMG.

  9. NIR spectrometry for counterfeit drug detection - A feasibility study

    DEFF Research Database (Denmark)

    Rodionova, O.Y.; Houmøller, Lars P.; Pomerantsev, A.L.

    2005-01-01

    Express-methods for detection of counterfeit drugs are of vital necessity. Visual control, dissociating tests or simple color reaction tests reveal only very rough forgeries. The feasibility of information-rich NIR-measurements as an analytical method together with multivariate calibration...... for mathematical data processing for false drugs detection is demonstrated. Also, multivariate hyperspectral image analysis is applied providing additional diagnostic information. Hyperspectral imaging is becoming a useful diagnostic tool for identifying non-homogeneous spatial regions of drug formulation. Two...... types of drugs are used to demonstrate the applicability of these approaches....

  10. In vivo sensing of proteolytic activity with an NSET-based NIR fluorogenic nanosensor.

    Science.gov (United States)

    Ku, Minhee; Hong, Yoochan; Heo, Dan; Lee, Eugene; Hwang, Seungyeon; Suh, Jin-Suck; Yang, Jaemoon

    2016-03-15

    Biomedical in vivo sensing methods in the near-infrared (NIR) range, which that provide relatively high photon transparency, separation from auto-fluorescence background, and extended sensitivity, are being used increasingly for non-invasive mapping and monitoring of molecular events in cancer cells. In this study, we fabricated an NIR fluorogenic nanosensor based on the nanoparticle surface energy transfer effect, by conjugation of fluorescent proteolytic enzyme-specific cleavable peptides with gold nanorods (GNRs). Membrane-anchored membrane type 1-matrix metalloproteinases (MT1-MMPs), a family of zinc-dependent proteolytic enzymes, can induce the metastatic potential of cancer cells by promoting degradation of the extracellular matrix. Therefore, sensitive detection of MT1-MMP activity can provide essential information in the clinical setting. We have applied in vivo NIR sensing to evaluate MT1-MMP activity, as an NIR imaging target, in an MT1-MMP-expressing metastatic tumor mouse model.

  11. A Near-Infrared (NIR) Global Multispectral Map of the Moon from Clementine

    Science.gov (United States)

    Eliason, E. M.; Lee, E. M.; Becker, T. L.; Weller, L. A.; Isbell, C. E.; Staid, M. I.; Gaddis, L. R.; McEwen, A. S.; Robinson, M. S.; Duxbury, T.

    2003-01-01

    In May and June of 1994, the NASA/DoD Clementine Mission acquired global, 11- band, multispectral observations of the lunar surface using the ultraviolet-visible (UVVIS) and near-infrared (NIR) camera systems. The global 5-band UVVIS Digital Image Model (DIM) of the Moon at 100 m/pixel was released to the Planetary Data System (PDS) in 2000. The corresponding NIR DIM has been compiled by the U.S. Geological Survey for distribution to the lunar science community. The recently released NIR DIM has six spectral bands (1100, 1250, 1500, 2000, 2600, and 2780 nm) and is delivered in 996 quads at 100 m/pixel (303 pixels/degree). The NIR data were radiometrically corrected, geometrically controlled, and photometrically normalized to form seamless, uniformly illuminated mosaics of the lunar surface.

  12. Coupling of guided Surface Plasmon Polaritons to proximal self-assembled InGaAs Quantum Dots

    CERN Document Server

    Bracher, Gregor; Blauth, Mäx; Jakubeit, Clemens; Müller, Kai; Koblmüller, Gregor; Bichler, Max; Kaniber, Michael; Finley, Jonathan J

    2012-01-01

    We present investigations of the propagation length of guided surface plasmon polaritons along Au waveguides on GaAs and their coupling to near surface InGaAs self-assembled quantum dots. Our results reveal surface plasmon propagation lengths ranging from 13.4 {\\pm} 1.7 {\\mu}m to 27.5 {\\pm} 1.5 {\\mu}m as the width of the waveguide increases from 2-5 {\\mu}m. Experiments performed on active structures containing near surface quantum dots clearly show that the propagating plasmon mode excites the dot, providing a new method to spatially image the surface plasmon mode. We use low temperature confocal microscopy with polarization control in the excitation and detection channel. After excitation, plasmons propagate along the waveguide and are scattered into the far field at the end. By comparing length and width evolution of the waveguide losses we determine the plasmon propagation length to be 27.5 {\\pm} 1.5 {\\mu}m at 830 nm (for a width of 5 {\\mu}m), reducing to 13.4 {\\pm} 1.7 {\\mu}m for a width of 2 {\\mu}m. For ...

  13. Design and synthesis of polymer-functionalized NIR fluorescent dyes--magnetic nanoparticles for bioimaging.

    Science.gov (United States)

    Yen, Swee Kuan; Jańczewski, Dominik; Lakshmi, Jeeva Lavanya; Dolmanan, Surani Bin; Tripathy, Sudhiranjan; Ho, Vincent H B; Vijayaragavan, Vimalan; Hariharan, Anushya; Padmanabhan, Parasuraman; Bhakoo, Kishore K; Sudhaharan, Thankiah; Ahmed, Sohail; Zhang, Yong; Tamil Selvan, Subramanian

    2013-08-27

    The fluorescent probes having complete spectral separation between absorption and emission spectra (large Stokes shift) are highly useful for solar concentrators and bioimaging. In bioimaging application, NIR fluorescent dyes have a greater advantage in tissue penetration depth compared to visible-emitting organic dyes or inorganic quantum dots. Here we report the design, synthesis, and characterization of an amphiphilic polymer, poly(isobutylene-alt-maleic anhyride)-functionalized near-infrared (NIR) IR-820 dye and its conjugates with iron oxide (Fe3O4) magnetic nanoparticles (MNPs) for optical and magnetic resonance (MR) imaging. Our results demonstrate that the Stokes shift of unmodified dye can be tuned (from ~106 to 208 nm) by the functionalization of the dye with polymer and MNPs. The fabrication of bimodal probes involves (i) the synthesis of NIR fluorescent dye (IR-820 cyanine) functionalized with ethylenediamine linker in high yield, >90%, (ii) polymer conjugation to the functionalized NIR fluorescent dye, and (iii) grafting the polymer-conjugated dyes on iron oxide MNPs. The resulting uniform, small-sized (ca. 6 nm) NIR fluorescent dye-magnetic hybrid nanoparticles (NPs) exhibit a wider emissive range (800-1000 nm) and minimal cytotoxicity. Our preliminary studies demonstrate the potential utility of these NPs in bioimaging by means of direct labeling of cancerous HeLa cells via NIR fluorescence microscopy and good negative contrast enhancement in T2-weighted MR imaging of a murine model.

  14. Not Afraid of the Dark: NIR-VIS Face Recognition via Cross-spectral Hallucination and Low-rank Embedding

    OpenAIRE

    2016-01-01

    Surveillance cameras today often capture NIR (near infrared) images in low-light environments. However, most face datasets accessible for training and verification are only collected in the VIS (visible light) spectrum. It remains a challenging problem to match NIR to VIS face images due to the different light spectrum. Recently, breakthroughs have been made for VIS face recognition by applying deep learning on a huge amount of labeled VIS face samples. The same deep learning approach cannot ...

  15. NIR Tully-Fisher in the Zone of Avoidance - III. Deep NIR catalogue of the HIZOA galaxies

    Science.gov (United States)

    Said, Khaled; Kraan-Korteweg, Renée C.; Jarrett, T. H.; Staveley-Smith, Lister; Williams, Wendy L.

    2016-11-01

    We present a deep near-infrared (NIR; J, H, and Ks bands) photometric catalogue of sources from the Parkes H I Zone of Avoidance (HIZOA) survey, which forms the basis for an investigation of the matter distribution in the Zone of Avoidance. Observations were conducted between 2006 and 2013 using the Infrared Survey Facility (IRSF), a 1.4-m telescope situated at the South African Astronomical Observatory site in Sutherland. The images cover all 1108 HIZOA detections and yield 915 galaxies. An additional 105 bright 2MASS galaxies in the southern ZOA were imaged with the IRSF, resulting in 129 galaxies. The average Ks-band seeing and sky background for the survey are 1.38 arcsec and 20.1 mag, respectively. The detection rate as a function of stellar density and dust extinction is found to depend mainly on the H I mass of the H I detected galaxies, which in principal correlates with the NIR brightness of the spiral galaxies. The measured isophotal magnitudes are of sufficient accuracy (errors ˜0.02 mag) to be used in a Tully-Fisher analysis. In the final NIR catalogue, 285 galaxies have both IRSF and 2MASS photometry (180 HIZOA plus 105 bright 2MASX galaxies). The Ks-band isophotal magnitudes presented in this paper agree, within the uncertainties, with those reported in the 2MASX catalogue. Another 30 galaxies, from the HIZOA northern extension, are also covered by UKIDSS Galactic Plane Survey (GPS) images, which are one magnitude deeper than our IRSF images. A modified version of our photometry pipeline was used to derive the photometric parameters of these UKIDSS galaxies. Good agreement was found between the respective Ks-band isophotal magnitudes. These comparisons confirm the robustness of the isophotal parameters and demonstrate that the IRSF images do not suffer from foreground contamination, after star removal, nor underestimate the isophotal fluxes of ZoA galaxies.

  16. NIR-camera-based online diagnostics of laser beam welding processes

    Science.gov (United States)

    Dorsch, Friedhelm; Braun, Holger; Keßler, Steffen; Pfitzner, Dieter; Rominger, Volker

    2012-03-01

    We have developed an on-axis camera-based online sensor system for laser beam welding diagnostics that detects the thermal radiation in the near-infrared (NIR) spectral range between 1200 and 1700 nm. In addition to a sensor in the visible (VIS) range, our camera detects the thermal radiation of the weld pool more clearly, and it is also sensible to the radiation of the solidified weld seam. The NIR images are analyzed by real-time image processing. Features are extracted from the images and evaluated to characterize the welding process. Keyhole and weld pool analysis complement VIS diagnostics, whereas the observation of the weld seam and heat affected zone with an NIR camera allows online heat flux thermography. By this means we are able to detect bad joints in overlap weldings ("false friends") online during the welding process.

  17. Near-infrared (NIR) up-conversion optogenetics

    Science.gov (United States)

    Hososhima, Shoko; Yuasa, Hideya; Ishizuka, Toru; Hoque, Mohammad Razuanul; Yamashita, Takayuki; Yamanaka, Akihiro; Sugano, Eriko; Tomita, Hiroshi; Yawo, Hiromu

    2015-11-01

    Non-invasive remote control technologies designed to manipulate neural functions have been long-awaited for the comprehensive and quantitative understanding of neuronal network in the brain as well as for the therapy of neurological disorders. Recently, it has become possible for the neuronal activity to be optically manipulated using biological photo-reactive molecules such as channelrhodopsin (ChR)-2. However, ChR2 and its relatives are mostly reactive to visible light, which does not effectively penetrate through biological tissues. In contrast, near-infrared (NIR) light (650-1450 nm) penetrates deep into the tissues because biological systems are almost transparent to light within this so-called ‘imaging window’. Here we used lanthanide nanoparticles (LNPs), composed of rare-earth elements, as luminous bodies to activate ChRs since they absorb low-energy NIR light to emit high-energy visible light (up-conversion). Here, we created a new type of optogenetic system which consists of the donor LNPs and the acceptor ChRs. The NIR laser irradiation emitted visible light from LNPs, then induced the photo-reactive responses in the near-by cells that expressed ChRs. However, there remains room for large improvements in the energy efficiency of the LNP-ChR system.

  18. Pixel-by-pixel VIS/NIR and LIR sensor fusion system

    Science.gov (United States)

    Zhang, Evan; Zhang, James S.; Song, Vivian W.; Chin, Ken P.; Hu, Gelbert

    2003-01-01

    Visible (VIS) camera (such as CCD) or Near Infrared (NIR) camera (such as low light level CCD or image intensifier) has high resolution and is easy to distinguish enemy and foe, but it cannot see through thin fog/cloud, heavy smoke/dust, foliage, camouflage, and darkness. The Long Infrared (LIR) imager can overcome above problems, but the resolution is too low and it cannot see the NIR aiming light from enemy. The best solution is to fuse the VIS/NIR and LIR sensors to overcome their shortcomings and take advantages of both sensors. In order to see the same target without parallax, the fusio system must have a common optical aperature. In this paper, three common optical apertures are designed: common reflective objective lens, common beam splitter, and common transmissive objective lens. The first one has very small field of view and the second one needs two heads, so the best choice is the third one, but we must find suitable optical materials and correct the color aberrations from 0.6 to 12 μ. It is a tough job. By choosing ZnSe as the first common piece of the objective lens and using glass for NIR and Ge (or IR glass) for LIR as rest pieces, we only need to and are able to correct the aberrations from 0.6 to 1.0 μ for NIR and from 8 to 12 μ for LIR. Finally, a common reflective objective lens and the common beam splitter are also successfully designed. Five application examples are given. In the digital signal processing, we use only one Altera chip. After inserting data, scaling the image size, and adjusting the signal level, the LIR will have the same format and same pixel number of the VIS/NIR, so real-time pixel-by-pixel sensor fusion is realized. The digital output can be used for further image processing and automatic target recognition, such as if we overlap the LIR image on the VIS/NIR image for missile guidance or rifle sight we don't need to worry about the time and the environment again. A gum-size wireless transmitter is also designed that is

  19. Near-infrared (NIR) optogenetics using up-conversion system

    Science.gov (United States)

    Hososhima, Shoko; Yuasa, Hideya; Ishizuka, Toru; Yawo, Hiromu

    2015-03-01

    Non-invasive remote control technologies designed to manipulate neural functions for a comprehensive and quantitative understanding of the neuronal network in the brain as well as for the therapy of neurological disorders have long been awaited. Recently, it has become possible to optically manipulate the neuronal activity using biological photo-reactive molecules such as channelrhodopsin-2 (ChR2). However, ChR2 and its relatives are mostly reactive to visible light which does not effectively penetrate through biological tissues. In contrast, near-infrared (NIR) light penetrates deep into the tissues because biological systems are almost transparent to light within this so-called `imaging window'. Here we used lanthanide nanoparticles (LNPs), which are composed of rare-earth elements, as luminous bodies to activate channelrhodopsins (ChRs) since they absorb low-energy NIR light to emit high-energy visible light (up-conversion). Neuron-glioma-hybrid ND-7/23 cells were cultured with LNP(NaYF4:Sc/Yb/Er) particles (peak emission, 543 nm) and transfected to express C1V1 (peak absorbance, 539 nm), a chimera of ChR1 and VChR1. The photocurrents were generated in response to NIR laser light (976 nm) to a level comparable to that evoked by a filtered Hg lamp (530-550 nm). NIR light pulses also evoked action potentials in the cultured neurons that expressed C1V1. It is suggested that the green luminescent light emitted from LNPs effectively activated C1V1 to generate the photocurrent. With the optimization of LNPs, acceptor photo-reactive biomolecules and optics, this system could be applied to non-invasively actuate neurons deep in the brain.

  20. Sediment denitrifier community composition and nirS gene expression investigated with functional gene microarrays

    DEFF Research Database (Denmark)

    Francis, C.A.; Jackson, G.A.; Ward, B.B.

    2008-01-01

    total RNA extracts) targets were hybridized to the same array to compare the profiles of community composition at the DNA (relative abundance) and mRNA (gene expression) levels. Only the three dominant denitrifying groups (in terms of relative strength of DNA hybridization signal) were detected at the m......A functional gene microarray was used to investigate denitrifier community composition and nitrite reductase (nirS) gene expression in sediments along the estuarine gradient in Chesapeake Bay, USA. The nirS oligonucleotide probe set was designed to represent a sequence database containing 539...

  1. Pear quality characteristics by Vis / NIR spectroscopy.

    Science.gov (United States)

    Machado, Nicácia P; Fachinello, José C; Galarça, Simone P; Betemps, Débora L; Pasa, Mateus S; Schmitz, Juliano D

    2012-09-01

    Recently, non-destructive techniques such as the Vis / NIR spectroscopy have been used to evaluate the characteristics of maturation and quality of pears. The study aims to validate the readings by the Vis / NIR spectroscopy as a non-destructive way to assess the qualitative characteristics of pear cultivars 'Williams', 'Packams' and 'Carrick', produced according to Brazilian conditions. The experiment was conducted at the Pelotas Federal University, UFPel, in Pelotas / RS, and the instrument used to measure the fruit quality in a non-destructive way was the NIR- Case spectrophotometer (SACMI, Imola, Italy). To determine pears' soluble solids (SS) and pulp firmness (PF), it was established calibration equations for each variety studied, done from the evaluations obtained by a non-destructive method (NIR-Case) and a destructive method. Further on, it was tested the performance of these readings by linear regressions. The results were significant for the soluble solids parameter obtained by the Vis / NIR spectroscopy; however, it did not achieve satisfactory results for the pear pulp firmness of these cultivars. It is concluded that the Vis / NIR spectroscopy, using linear regression, allows providing reliable estimates of pears' quality levels, especially for soluble solids.

  2. Angular switching of the linear polarization of the emission in InGaAs microcavities

    Energy Technology Data Exchange (ETDEWEB)

    Amo, A.; Martin, M.D.; Ballarini, D.; Vina, L. [Grupo de Semiconductores (SEMICUAM), Departamento de Fisica de Materiales, Universidad Autonoma de Madrid, 28049 Madrid (Spain); Sanvitto, D.; Skolnick, M.S. [Dept. of Physics, University of Sheffield, S3 7RH, Sheffield (United Kingdom); Roberts, J.S. [Dept. of Electronic and Electrical Engineering, University of Sheffield, 3JD, Sheffield (United Kingdom)

    2005-11-01

    The angular dependence of the degree of linear polarization of the emission is presented for an InGaAs microcavity at several detunings. For emission angles close to the growth direction, polarizations as high as +80% for lower branch polaritons at negative detuning are found. This polarization degree abruptly switches to negative values (up to -90%) for emission angles outside a narrow cone of about {+-}2 . A similar behaviour, with smaller values of the polarization, is found at 0 and positive detunings. The relation between these effects and cavity birefringence is discussed. (copyright 2005 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  3. Growth and optical properties of self-assembled InGaAs Quantum Posts

    CERN Document Server

    Krenner, H J; He, J; Zhang, J P; Wu, Y; Morris, C M; Sherwin, M S; Petroff, P M

    2007-01-01

    We demonstrate a method to grow height controlled, dislocation-free InGaAs quantum posts (QPs) on GaAs by molecular beam epitaxy (MBE) which is confirmed by structural investigations. The optical properties are compared to realistic 8-band k.p calculations of the electronic structure which fully account for strain and the structural properties of the QP. Using QPs embedded in n-i-p junctions we find wide range tunability of the interband spectrum and giant static dipole moments.

  4. RF and DC Analysis of Stressed InGaAs MOSFETs

    OpenAIRE

    Roll, Guntrade; Lind, Erik; Egard, Mikael; Johansson, Sofia; Ohlsson, Lars; Wernersson, Lars-Erik

    2014-01-01

    A complete reliability study of the DC and RF characteristics for InGaAs nMOSFETs with aluminium oxide/ hafnium oxide dielectric is presented. The main stress variation at high frequencies is related to a threshold voltage shift, whereas no decrease is found in the maximum of the cut-off frequency and RF-transconductance. Constant gate stress leads to a charge build up causing a threshold voltage shift. Furthermore, electron trapping at the drain side degrades the performance after hot carrie...

  5. Real-time, non-invasive monitoring of hydrogel degradation using LiYF4:Yb(3+)/Tm(3+) NIR-to-NIR upconverting nanoparticles.

    Science.gov (United States)

    Jalani, Ghulam; Naccache, Rafik; Rosenzweig, Derek H; Lerouge, Sophie; Haglund, Lisbet; Vetrone, Fiorenzo; Cerruti, Marta

    2015-07-14

    To design a biodegradable hydrogel as cell support, one should know its in vivo degradation rate. A technique commonly used to track gel degradation is fluorescence spectroscopy. However, the fluorescence from conventional fluorophores quickly decays, and the fluorophores are often moderately cytotoxic. Most importantly, they require ultraviolet or visible (UV-Vis) light as the excitation source, which cannot penetrate deeply through biological tissues. Lanthanide-doped upconverting nanoparticles (UCNPs) are exciting alternatives to conventional fluorophores because they can convert near-infrared (NIR) to UV-Vis-NIR light via a sequential multiphoton absorption process referred to as upconversion. NIR light can penetrate up to few cm inside tissues, thus making these UCNPs much better probes than conventional fluorophores for in vivo monitoring. Also, UCNPs have narrow emission bands, high photoluminescence (PL) signal-to-noise ratio, low cytotoxicity and good physical and chemical stability. Here, we show a nanocomposite system consisting of a biodegradable, in situ thermogelling injectable hydrogel made of chitosan and hyaluronic acid encapsulating silica-coated LiYF4:Yb(3+)/Tm(3+) UCNPs. We use these UCNPs as photoluminescent tags to monitor the gel degradation inside live, cultured intervertebral discs (IVDs) over a period of 3 weeks. PL spectroscopy and NIR imaging show that NIR-to-NIR upconversion of LiYF4:Yb(3+)/Tm(3+)@SiO2 UCNPs allows for tracking of the gel degradation in living tissues. Both in vitro and ex vivo release of UCNPs follow a similar trend during the first 5 days; after this time, ex vivo release becomes faster than in vitro, indicating a faster gel degradation ex vivo. Also, the amount of released UCNPs in vitro increases continuously up to 3 weeks, while it plateaus after 15 days inside the IVDs showing a homogenous distribution of UCNPs throughout the IVD tissue. This non-invasive optical method for real time, live tissue imaging holds

  6. Assessing the feasibility of time-resolved fNIRS to detect brain activity during motor imagery

    Science.gov (United States)

    Abdalmalak, Androu; Milej, Daniel; Diop, Mamadou; Naci, Lorina; Owen, Adrian M.; St. Lawrence, Keith

    2016-03-01

    Functional near-infrared spectroscopy (fNIRS) is a non-invasive optical technique for detecting brain activity, which has been previously used during motor and motor executive tasks. There is an increasing interest in using fNIRS as a brain computer interface (BCI) for patients who lack the physical, but not the mental, ability to respond to commands. The goal of this study is to assess the feasibility of time-resolved fNIRS to detect brain activity during motor imagery. Stability tests were conducted to ensure the temporal stability of the signal, and motor imagery data were acquired on healthy subjects. The NIRS probes were placed on the scalp over the premotor cortex (PMC) and supplementary motor area (SMA), as these areas are responsible for motion planning. To confirm the fNIRS results, subjects underwent functional magnetic resonance imaging (fMRI) while performing the same task. Seven subjects have participated to date, and significant activation in the SMA and/or the PMC during motor imagery was detected by both fMRI and fNIRS in 4 of the 7 subjects. No activation was detected by either technique in the remaining three participants, which was not unexpected due to the nature of the task. The agreement between the two imaging modalities highlights the potential of fNIRS as a BCI, which could be adapted for bedside studies of patients with disorders of consciousness.

  7. Near-IR Imaging of Thermal Changes in Enamel during Laser Ablation.

    Science.gov (United States)

    Maung, Linn H; Lee, Chulsung; Fried, Daniel

    2010-03-05

    The objective of this work was to observe the various thermal-induced optical changes that occur in the near-infrared (NIR) during drilling in dentin and enamel with the laser and the high-speed dental handpiece. Tooth sections of ~ 3 mm-thickness were prepared from extracted human incisors (N=60). Samples were ablated with a mechanically scanned CO(2) laser operating at a wavelength of 9.3-µm, a 300-Hz laser pulse repetition rate, and a laser pulse duration of 10-20 µs. An InGaAs imaging camera was used to acquire real-time NIR images at 1300-nm of thermal and mechanical changes (cracks). Enamel was rapidly removed by the CO(2) laser without peripheral thermal damage by mechanically scanning the laser beam while a water spray was used to cool the sample. Comparison of the peripheral thermal and mechanical changes produced while cutting with the laser and the high-speed hand-piece suggest that enamel and dentin can be removed at high speed by the CO(2) laser without excessive peripheral thermal or mechanical damage. Only 2 of the 15 samples ablated with the laser showed the formation of small cracks while 9 out of 15 samples exhibited crack formation with the dental hand-piece. The first indication of thermal change is a decrease in transparency due to loss of the mobile water from pores in the enamel which increase light-scattering. To test the hypothesis that peripheral thermal changes were caused by loss of mobile water in the enamel, thermal changes were intentionally induced by heating the surface. The mean attenuation coefficient of enamel increased significantly from 2.12 ± 0.82 to 5.08 ± 0.98 with loss of mobile water due to heating.

  8. MT6415CA: a 640×512-15µm CTIA ROIC for SWIR InGaAs detector arrays

    Science.gov (United States)

    Eminoglu, Selim; Isikhan, Murat; Bayhan, Nusret; Gulden, M. Ali; Incedere, O. Samet; Soyer, S. Tuncer; Kocak, Serhat; Yilmaz, Gokhan S.; Akin, Tayfun

    2013-06-01

    This paper reports the development of a new low-noise CTIA ROIC (MT6415CA) suitable for SWIR InGaAs detector arrays for low-light imaging applications. MT6415CA is the second product in the MT6400 series ROICs from Mikro-Tasarim Ltd., which is a fabless IC design house specialized in the development of monolithic imaging sensors and ROICs for hybrid imaging sensors. MT6415CA is a low-noise snapshot CTIA ROIC, has a format of 640 × 512 and pixel pitch of 15 µm, and has been developed with the system-on-chip architecture in mind, where all the timing and biasing for this ROIC are generated on-chip without requiring any external inputs. MT6415CA is a highly configurable ROIC, where many of its features can be programmed through a 3-wire serial interface allowing on-the-fly configuration of many ROIC features. It performs snapshot operation both using Integrate-Then-Read (ITR) and Integrate-While-Read (IWR) modes. The CTIA type pixel input circuitry has three gain modes with programmable full-well-capacity (FWC) values of 10.000 e-, 20.000 e-, and 350.000 e- in the very high gain (VHG), high-gain (HG), and low-gain (LG) modes, respectively. MT6415CA has an input referred noise level of less than 5 e- in the very high gain (VHG) mode, suitable for very low-noise SWIR imaging applications. MT6415CA has 8 analog video outputs that can be programmed in 8, 4, or 2-output modes with a selectable analog reference for pseudo-differential operation. The ROIC runs at 10 MHz and supports frame rate values up to 200 fps in the 8-output mode. The integration time can be programmed up to 1s in steps of 0.1 µs. The ROIC uses 3.3 V and 1.8V supply voltages and dissipates less than 150 mW in the 4-output mode. MT6415CA is fabricated using a modern mixed-signal CMOS process on 200 mm CMOS wafers, and tested parts are available at wafer or die levels with test reports and wafer maps. A compact USB 3.0 camera and imaging software have been developed to demonstrate the imaging

  9. Improved micro-distribution of antibody-photon absorber conjugates after initial near infrared photoimmunotherapy (NIR-PIT).

    Science.gov (United States)

    Nagaya, Tadanobu; Nakamura, Yuko; Sato, Kazuhide; Harada, Toshiko; Choyke, Peter L; Kobayashi, Hisataka

    2016-06-28

    Near infrared photoimmunotherapy (NIR-PIT), a targeted cancer therapy which uses an antibody-photo absorber conjugate (APC) and near infrared light exposure, dramatically improves nano-drug delivery into treated tumor beds due to enhanced vascular permeability. We investigated the micro-distribution of APCs in a variety of NIR-PIT treated tumors. Either cetuximab (cet) or trastuzumab (tra) conjugated with IR700 (cet-tra-IR700) was administered, as appropriate, to each mouse model of tumor. Tumor-bearing mice implanted with A431-GFP, MDAMB468-GFP, 3T3Her2-GFP or N87-GFP were separated into 5 groups: group 1=no treatment; group 2=cet-tra-IR700 i.v., no light exposure; group 3=cet-tra-IR700 i.v., NIR light exposure; group 4=cet-tra-IR700 i.v. and additional cet-tra-IR700 i.v. at 24h but no light exposure; group 5=cet-tra-IR700 i.v., NIR light exposure and additional cet-tra-IR700 i.v. immediately after NIR but no additional NIR light exposure. In vivo, ex vivo and microscopic fluorescence imaging was performed. Fluorescence from the surface of the tumor (s-tumor) was compared to fluorescence from deeper areas of the tumor (d-tumor). In general, there was no significant difference in the fluorescence intensity of GFP in the tumors among all groups, however the highest IR700 fluorescence intensity was consistently shown in group 5 tumors due to added APC after NIR-PIT. Fluorescence microscopy in all tumor types demonstrated that GFP relative fluorescence intensity (RFI) in s-tumor was significantly lower in group 3 and 5 (NIR-PIT groups) than in group 1, 2, and 4 (no NIR-PIT) yet there was no significant difference in d-tumor RFI among all groups. IR700 fluorescent RFI in the d-tumor was highest in group 5 (NIR-PIT+additional APC) compared to the other groups. Cell killing after NIR-PIT was primarily on the surface, however, APCs administered immediately after NIR-PIT penetrated deeper into tissue resulting in improved cell killing after a 2nd NIR-PIT session. This

  10. Comparative NIR Detector Characterization for NGST

    Science.gov (United States)

    Greenhouse, Matthew (Technical Monitor); Figer, Donald

    2004-01-01

    List of publications for final perfomance report are: Detectors for the JWST Near-Infrared Spectrometer Rauscher, B.J., Strada, P., Regan, M.W., Figer, D.F., Jakobsen, P., Moseley, H.S., & Boeker, T. 2004, SPIE Detectors for the JWST Near-Infrared Spectrometer Rauscher, B.J., Strada, P., Regan, M.W., Figer, D.F., Jakobsen, P., Moseley, H.S., & Boeker, T. 2004, AAS, 203, 124.07 Independent Testing of JWST Detector Prototypes Figer, D.F., Rauscher, B. J., Regan, M. W., Morse, E., Balleza, J., Bergeron, L., & Stockman, H. S. 2003 , SPIE, 5 167 The Independent Detector Testing Laboratory and the NGST Detector Program Figer, D.F., Agronin, M., Balleza, J., Barkhouser, R., Bergeron, L., Greene, G. R., McCandliss, S. R., Rauscher, B. J., Reeves, T., Regan, M. W., Sharma, U., Stockman, H. S. 2003, SPIE, 4850,981 Intra-Pixel Sensitivity in NIR Detectors for NGST Sharma, U., Figer, D.F., Sivaramakrishnan, A., Agronin, M., Balleza, J., Barkhouser, R., Bergeron, L., Greene, G. R., McCandliss, S. R., Rauscher, B. J., Reeves, T., Regan, M. W., Stockman, H. S. 2003, SPIE, 4850,1001 NIRCAM Image Simulations for NGST Wavefiont SensinglPS A. Sivaramakrishnan, D. Figer, H. Bushouse, H. S. Stockman (STScI),C. Ohara , D. Redding (JPL), M. Im (IPAC), & J. Offenberg (Raytheon) 2003, SPIE, 4850,388 Ultra-Low Background Operation of Near-Infrared Detectors for NGS Rauscher, B. J., Figer, D. F., Agronin, M., Balleza, J., Barkhouser, R., Bergeron, L., Greene, G. R., McCandliss, S. R., Reeves, T., Regan, M. W., Sharma, U., Stockman, H. S. 2003, SPIE, 4850,962 The Independent Detector Testing Laboratory and the JWST Detector Program Figer, D.F. et a1.2003, AAS201, #131.05

  11. Photoswitchable NIR-Emitting Gold Nanoparticles.

    Science.gov (United States)

    Bonacchi, Sara; Cantelli, Andrea; Battistelli, Giulia; Guidetti, Gloria; Calvaresi, Matteo; Manzi, Jeannette; Gabrielli, Luca; Ramadori, Federico; Gambarin, Alessandro; Mancin, Fabrizio; Montalti, Marco

    2016-09-05

    Photo-switching of the NIR emission of gold nanoparticles (GNP) upon photo-isomerization of azobenzene ligands, bound to the surface, is demonstrated. Photophysical results confirm the occurrence of an excitation energy transfer process from the ligands to the GNP that produces sensitized NIR emission. Because of this process, the excitation efficiency of the gold core, upon excitation of the ligands, is much higher for the trans form than for the cis one, and t→c photo-isomerization causes a relevant decrease of the GNP NIR emission. As a consequence, photo-isomerization can be monitored by ratiometric detection of the NIR emission upon dual excitation. The photo-isomerization process was followed in real-time through the simultaneous detection of absorbance and luminescence changes using a dedicated setup. Surprisingly, the photo-isomerization rate of the ligands, bound to the GNP surface, was the same as measured for the chromophores in solution. This outcome demonstrated that excitation energy transfer to gold assists photo-isomerization, rather than competing with it. These results pave the road to the development of new, NIR-emitting, stimuli-responsive nanomaterials for theranostics.

  12. Gated Hall Effect Measurements on Selectively grown InGaAs Nanowires.

    Science.gov (United States)

    Lindelöw, Fredrik Gustav; Zota, Cezar; Lind, Erik

    2017-02-23

    InGaAs nanowires is one of the promising material systems of replacing silicon in future CMOS transistors, due to its high electron mobility, in combination with the excellent electrostatic control from the tri-gate geometry. In this article, we report on gated Hall measurements on single and multiple In0.85Ga0.15As nanowires, selectively grown in a Hall bridge geometry with nanowire widths down to 50 nm and thicknesses of 10 nm. The gated nanowires can be used as junctionless transistors, which allows for a simplified device processing as no regrowth of contact layer or ion implantation is needed, which is especially beneficial as transistor dimensions are scaled down. The analysis shows that the InGaAs layer has a carrier concentration above 10^19 cm^-3, with a Hall carrier mobility of around 1000 cm^2V^-1s^-1. The gated Hall measurements reveal an increased carrier concentration as a function of applied gate voltage, with an increasing mobility for narrow nanowires but no significant effect on larger nanowires.

  13. Modeling and optimization of InGaAs infrared photovoltaic detectors

    CERN Document Server

    Piotrowski, J; Reginski, K

    2000-01-01

    The performance of In sub x Ga sub 1 sub - sub x As detectors operating in the 2-3.4 mu m spectral range and temperature of 300 K has been analyzed theoretically as a function of wavelength, band gap and doping level with special emphasis on 2-2.5 mu m and 3-3.5 mu m atmospheric window devices. The calculations show that the dominant generation-recombination mechanism in p-type, intrinsic and in a lightly doped n-type InGaAs is the spin split-off band Auger process (AS). Since the AS generation increases with the square of the hole concentration, the minimum thermal generation and the best performance can be obtained using moderately doped n-type material as the absorber region of a photovoltaic device. In principle, the ultimate performance can be achieved in the optimized homojunction devices with relatively thick n-type absorber region forming n-p junction with a thin p-type material. N-type doping of absorber region of InGaAs photodiodes at 300 K changes from 1x10 sup 1 sup 4 to 5.2x10 sup 1 sup 5 cm sup ...

  14. Buffer Layer Effects on Tandem InGaAs TPV Devices

    Science.gov (United States)

    Wilt, David M.; Wehrer, Rebecca J.; Maurer, William F.

    2004-01-01

    Single junction indium gallium arsenide (InGaAs) based TPV devices have demonstrated efficiencies in excess of 20% at radiator temperatures of 1058 C. Modeling suggests that efficiency improvements in single bandgap devices should continue although they will eventually plateau. One approach for extending efficiencies beyond the single bandgap limit is to follow the technique taken in the solar cell field, namely tandem TPV cells. Tandem photovoltaic devices are traditionally composed of cells of decreasing bandgap, connected electrically and optically in series. The incident light impinges upon the highest bandgap first. This device acts as a sieve, absorbing the high-energy photons, while allowing the remainder to pass through to the underlying cell(s), and so on. Tandem devices reduce the energy lost to overexcitation as well as reducing the current density (Jsc). Reduced Jsc results in lower resistive losses and enables the use of thinner and lower doped lateral current conducting layers as well as a higher pitch grid design. Fabricating TPV tandem devices utilizing InGaAs for all of the component cells in a two cell tandem necessitates the inclusion of a buffer layer in-between the high bandgap device (In0.53 Ga0.47As - 0.74eV) and the low bandgap device (In0.66Ga0.34As - 0.63eV) to accommodate the approximately 1% lattice strain generated due to the change in InGaAs composition. To incorporate only a single buffer layer structure, we have investigated the use of the indium phosphide (InP) substrate as a superstrate. Thus the high-bandgap, lattice- matched device is deposited first, followed by the buffer structure and the low-bandgap cell. The near perfect transparency of the high bandgap (1.35eV) iron-doped InP permits the device to be oriented such that the light enters through the substrate. In this paper we examine the impact of the buffer layer on the underlying lattice-matched InGaAs device. 0.74eV InGaAs devices were produced in a variety of

  15. NIR- and SWIR-based on-orbit vicarious calibrations for satellite ocean color sensors.

    Science.gov (United States)

    Wang, Menghua; Shi, Wei; Jiang, Lide; Voss, Kenneth

    2016-09-05

    The near-infrared (NIR) and shortwave infrared (SWIR)-based atmospheric correction algorithms are used in satellite ocean color data processing, with the SWIR-based algorithm particularly useful for turbid coastal and inland waters. In this study, we describe the NIR- and two SWIR-based on-orbit vicarious calibration approaches for satellite ocean color sensors, and compare results from these three on-orbit vicarious calibrations using satellite measurements from the Visible Infrared Imaging Radiometer Suite (VIIRS) onboard the Suomi National Polar-orbiting Partnership (SNPP). Vicarious calibration gains for VIIRS spectral bands are derived using the in situ normalized water-leaving radiance nLw(λ) spectra from the Marine Optical Buoy (MOBY) in waters off Hawaii. The SWIR vicarious gains are determined using VIIRS measurements from the South Pacific Gyre region, where waters are the clearest and generally stable. Specifically, vicarious gain sets for VIIRS spectral bands of 410, 443, 486, 551, and 671 nm derived from the NIR method using the NIR 745 and 862 nm bands, the SWIR method using the SWIR 1238 and 1601 nm bands, and the SWIR method using the SWIR 1238 and 2257 nm bands are (0.979954, 0.974892, 0.974685, 0.965832, 0.979042), (0.980344, 0.975344, 0.975357, 0.965531, 0.979518), and (0.980820, 0.975609, 0.975761, 0.965888, 0.978576), respectively. Thus, the NIR-based vicarious calibration gains are consistent with those from the two SWIR-based approaches with discrepancies mostly within ~0.05% from three data processing methods. In addition, the NIR vicarious gains (745 and 862 nm) derived from the two SWIR methods are (0.982065, 1.00001) and (0.981811, 1.00000), respectively, with the difference ~0.03% at the NIR 745 nm band. This is the fundamental basis for the NIR-SWIR combined atmospheric correction algorithm, which has been used to derive improved satellite ocean color products over open oceans and turbid coastal/inland waters. Therefore, a unified

  16. Pear quality characteristics by Vis / NIR spectroscopy

    Directory of Open Access Journals (Sweden)

    Nicácia P. Machado

    2012-09-01

    Full Text Available Recently, non-destructive techniques such as the Vis / NIR spectroscopy have been used to evaluate the characteristics of maturation and quality of pears. The study aims to validate the readings by the Vis / NIR spectroscopy as a non-destructive way to assess the qualitative characteristics of pear cultivars 'Williams', 'Packams' and 'Carrick', produced according to Brazilian conditions. The experiment was conducted at the Pelotas Federal University, UFPel, in Pelotas / RS, and the instrument used to measure the fruit quality in a non-destructive way was the NIR- Case spectrophotometer (SACMI, Imola, Italy. To determine pears' soluble solids (SS and pulp firmness (PF, it was established calibration equations for each variety studied, done from the evaluations obtained by a non-destructive method (NIR-Case and a destructive method. Further on, it was tested the performance of these readings by linear regressions. The results were significant for the soluble solids parameter obtained by the Vis / NIR spectroscopy; however, it did not achieve satisfactory results for the pear pulp firmness of these cultivars. It is concluded that the Vis / NIR spectroscopy, using linear regression, allows providing reliable estimates of pears' quality levels, especially for soluble solids.Recentemente, técnicas não destrutivas como a espectroscopia Vis/NIR têm sido utilizadas para avaliar as características de maturação e qualidade das peras. O trabalho tem como objetivo validar as leituras por espectroscopia Vis/NIR, como forma não destrutiva de avaliar as características qualitativas em peras das cultivares Williams, Packams e Carrick produzidas em condições brasileiras. O experimento foi realizado na Universidade Federal de Pelotas, UFPel, Pelotas/RS e o instrumento utilizado para determinar a qualidade dos frutos de forma não destrutiva foi o espectrofotômetro NIR-Case (SACMI, Imola, Itália. Para a determinação de sólidos solúveis (SS e firmeza

  17. Effect of size and composition fluctuations on the luminescent properties of ensemble of InGaAs nano-objects

    Science.gov (United States)

    Yakovliev, Artem; Holubenko, Roman

    2015-09-01

    The luminescent properties of InGaAs/GaAs heterostructures with InGaAs nanoscale objects were investigated. Multilayer heterostructures were grown using molecular beam epitaxy technique. The shapes of the photoluminescence spectra were studied in the temperature range from 10 K to 290 K. The electronic spectrum of heterosystems as well as the energy of interband transitions for InGaAs nano-objects were calculated for different sizes and InGaAs component composition. It is shown that the shape of the photoluminescence spectra is determined by the Gaussian distribution of the energy of band-to-band optical transitions between the ground states of the conduction band and valence band of nanoscale objects. The physical reason for the observed energy dispertion is the variation of sizes, heterogeneity of component composition and strain relief in the ensemble of InGaAs nano-objects. Non-monotonous temperature dependence of the width of the photoluminescence spectra indicates the existence of temperature-dependent redistribution of photoexcited charge carriers between neighbouring nanoislands having different energy of the ground states.

  18. NIR optimerer produktionen af gammeldags modnede sild

    DEFF Research Database (Denmark)

    Svensson, Vibeke Tølbøl; Bro, Rasmus; Nielsen, Henrik Hauch;

    2005-01-01

    Måling med nærinfrarødt (NIR) lys er et godt supplement til de nuværende metoder til at følge modningen af sild saltede i tønder. Det viser resultaterne af et forskningsprojekt udført i samarbejde mellem Lykkeberg A/S, Danmarks Fiskeriundersøgelser og Den Kgl Veterinær- og Landbohøjskole. Ved hjælp...... af avanceret matematik er det nemt og hurtigt at bestemme modningsgraden af sild direkte fra en NIR måling....

  19. Monitoring of whey quality with NIR spectroscopy

    DEFF Research Database (Denmark)

    Kucheryavskiy, Sergey; Lomborg, Carina

    2015-01-01

    The possibility of using near-infrared (NIR) spectroscopy for monitoring of liquid whey quality parameters during protein production process has been tested. The parameters included total solids, lactose, protein and fat content. The samples for the experiment were taken from real industrial...... processes and had a large variability for most of the parameters. Partial Least Squares (PLS) regression was used to make the prediction models based on NIR spectra taken at 30 and 40 °C. Using proper wavelength range allowed to get models for prediction of fat, protein and amount of total solids with very...

  20. Unsupervised defect segmentation of patterned materials under NIR illumination

    Energy Technology Data Exchange (ETDEWEB)

    Millan, Maria S; Escofet, Jaume [Departament d' Optica y Optometria, Universitat Politecnica de Catalunya, Campus Terrassa. 08222 Terrassa, Barcelona (Spain); Rallo, Miquel, E-mail: millan@oo.upc.edu [Departament de Matematica Aplicada III, Universitat Politecnica de Catalunya, Campus Terrassa. 08222 Terrassa, Barcelona (Spain)

    2011-01-01

    An unsupervised detection method for automatic flaw segmentation in patterned materials (textile, non-woven, paper) that has no need of any defect-free references or a training stage is presented in this paper. Printed materials having a pattern of colored squares, bands, etc. superimposed to the background texture can be advantageously analyzed using NIR illumination and a camera with enough sensitivity to this region of the spectrum. The contrast reduction of the pattern in the NIR image facilitates material inspection and defect segmentation. Underdetection and misdetection errors can be reduced in comparison with the inspection performed under visible illumination. For woven fabrics, with periodic structure, the algorithm is based on the structural feature extraction of the weave repeat from the Fourier transform of the sample image. These features are used to define a set of multiresolution bandpass filters adapted to the fabric structure that operate in the Fourier domain. Inverse Fourier transformation, binarization and merging of the information obtained at different scales lead to the output image that contains flaws segmented from the fabric background. For non-woven and random textured materials, the algorithm combines the multiresolution Gabor analysis of the sample image with a statistical analysis of the wavelet coefficients corresponding to each detail. The information of all the channels is merged in a single binary output image where the defect appears segmented from the background. The method is applicable to random, non-periodic, and periodic textures. Since all the information to inspect a sample is obtained from the sample itself, the method is proof against heterogeneities between different samples of the material, in-plane positioning errors, scale variations and lack of homogeneous illumination. Experimental results are presented for a variety of materials and defects.

  1. NIR Tully-Fisher in the Zone of Avoidance. -- III. Deep NIR catalogue of the HIZOA galaxies

    CERN Document Server

    Said, Khaled; Jarrett, T H; Staveley-Smith, Lister; Williams, Wendy L

    2016-01-01

    We present a deep near-infrared (NIR) photometric catalogue of sources from the Parkes HI Zone of Avoidance (HIZOA) survey, which forms the basis for an investigation of the matter distribution in the Zone of Avoidance. Observations were conducted between 2006 and 2013 using the Infrared Survey Facility (IRSF), a 1.4-m telescope situated at the South African Astronomical Observatory site in Sutherland. The images cover all 1108 HIZOA detections and yield 915 galaxies. An additional 105 bright 2MASS galaxies in the southern ZOA were imaged with the IRSF, resulting in 129 galaxies. The average $K_s$-band seeing and sky background for the survey are 1.38 arcsec and 20.1 mag, respectively. The detection rate as a function of stellar density and dust extinction is found to depend mainly on the HI mass of the HI detected galaxies, which in principal correlates with the NIR brightness of the spiral galaxies. The measured isophotal magnitudes are of sufficient accuracy (errors $\\sim$ 0.02 mag) to be used in a Tully-F...

  2. Agricultural applications of NIR reflectance and transmittance

    DEFF Research Database (Denmark)

    Gislum, René

    2009-01-01

    There has been a considerable increase in the use of near infrared (NIR) reflectance and transmittance spectroscopy technologies for rapid determination of quality parameters in agriculture, including applications within crop product quality, feed and food quality, manure quality, soil analyses etc...

  3. The effect of nitrate addition on abundance of nirK, nirS and gln genes in acidified Norway spruce forest soil

    Science.gov (United States)

    Bárta, Jiří; Tahovská, Karolina; Kaåa, Jiří; Antrå¯Čková, Hana Å.

    2010-05-01

    The denitrification is the main biotic process leading to loses of fixed nitrogen as well as removal of excess of nitrate (NO3-) from the soil environment. The reduction of NO2- to nitric oxide (NO) distinguishes the 'true' denitrifiers from other nitrate-respiring bacteria. This reaction is catalyzed by two different types of nitrite reductases, either a cytochrome cd1 encoded by nirS gene (nirS denitrifiers) or a Cu-containing enzyme encoded by nirK gene (nirK denitrifiers). The nirS denitrifiers are located mostly in rhizosphere, while the nirK denitrifiers are more abundant in bulk soil. These two groups can be also classified as markers of denitrification. Glutamine synthetase is one of the main bacterial NH4+ assimilating enzymes; it is coded by glnI gene. Glutamine synthetase is mostly active when N is the limiting factor for bacterial growth. There is recent evidence that the activity may be affected by the presence of alternative N source (i.e. NO3-). However, in anaerobic condition NO3- can be used also by the denitrifying bacteria so there may be strong competition for this nutrient. The laboratory experiment was performed to evaluate the effect of nitrates (NO3-) on abundance of nirK, nirS and gln gene copy numbers. The amount of NO3- corresponded to the actual atmospheric depositions on experimental sites in the Bohemian Forest. Litter organic layer (0-5cm of soil) was used for laboratory incubation experiment. Four replicates of control (no addition of NO3-), and NO3-addition were incubated anaerobically for one month. After the incubation DNA was extracted and the number of nirK, nirS and gln gene copies was determined using qPCR (SYBRGreen methodology). Results showed that the addition of NO3- significantly increased the number of nirK and nirS denitrifiers from 5.9x106 to 1.1x107 and from not detectable amount to 1.4x106, respectively. The gln gene copy number was also higher after NO3-addition. However, the difference was not statistically

  4. Development of PCR primer systems for amplification of nitrite reductase genes (nirK and nirS) to detect denitrifying bacteria in environmental samples

    Energy Technology Data Exchange (ETDEWEB)

    Braker, G.; Witzel, K.P. [Max-Planck-Inst. fuer Limnologie, Ploen (Germany); Fesefeldt, A. [Univ. Kiel (Germany). Inst. fuer Allgemeine Mikrobiologie

    1998-10-01

    A system was developed for the detection of denitrifying bacteria by the application of specific nitrite reductase gene fragments with PCR. Primer sequences were found for the amplification of fragments from both nitrite reductase genes (nirK and nirS) after comparative sequence analysis. Whenever amplification was tried with these primers, the known nir type of denitrifying laboratory cultures could be confirmed. Likewise, the method allowed a determination of the nir type of five laboratory strains. The nirK gene could be amplified from Blastobacter denitrificans, Alcaligenes xylosoxidans, and Alcaligenes sp. (DSM 30128); the nirS gene was amplified from Alcaligenes eutrophus DSM 530 and from the denitrifying isolate IFAM 3698. For each of the two genes, at least one primer combination amplified successfully for all of the test strains. Specific amplification products were not obtained wit h nondenitrifying bacteria or with strains of the other nir type. The specificity of the amplified products was confirmed by subsequent sequencing. These results suggest the suitability of the method for the qualitative detection of denitrifying bacteria in environmental samples. This was shown by applying the generally amplifying primer combination for each nir gene developed in this study to total DNA preparations from aquatic habitats.

  5. NIR-red spectral space based new method for soil moisture monitoring

    Institute of Scientific and Technical Information of China (English)

    ZHAN ZhiMing; QIN QiMing; GHULAN Abduwasit; WANG DongDong

    2007-01-01

    Drought is a complex natural disaster that occurs frequently. Soil moisture has been the main issue in remote monitoring of drought events as the most direct and important variable describing the drought. Spatio-temporal distribution and variation of soil moisture evidently affect surface evapotranspiration, agricultural water demand, etc. In this paper, a new simple method for soil moisture monitoring is developed using near-infrared versus red (NIR-red) spectral reflectance space. First, NIR-red spectral reflectance space is established using atmospheric and geometric corrected ETM+ data, which is manifested by a triangle shape, in which different surface covers have similar spatial distribution rules. Next, the model of soil moisture monitoring by remote sensing (SMMRS) is developed on the basis of the distribution characteristics of soil moisture in the NIR-red spectral reflectance space. Then, the SMMRS model is validated by comparison with field measured soil moisture data at different depths. The results showed that satellite estimated soil moisture by SMMRS is highly accordant with field measured data at 5 cm soil depth and average soil moisture at 0―20 cm soil depths, correlation coefficients are 0.80 and 0.87, respectively. This paper concludes that, being simple and effective, the SMMRS model has great potential to estimate surface moisture conditions.

  6. NIR-red spectral space based new method for soil moisture monitoring

    Institute of Scientific and Technical Information of China (English)

    GHULAN; Abduwasit

    2007-01-01

    Drought is a complex natural disaster that occurs frequently. Soil moisture has been the main issue in remote monitoring of drought events as the most direct and important variable describing the drought. Spatio-temporal distribution and variation of soil moisture evidently affect surface evapotranspiration, agricultural water demand, etc. In this paper, a new simple method for soil moisture monitoring is de- veloped using near-infrared versus red (NIR-red) spectral reflectance space. First, NIR-red spectral reflectance space is established using atmospheric and geometric corrected ETM+ data, which is manifested by a triangle shape, in which different surface covers have similar spatial distribution rules. Next, the model of soil moisture monitoring by remote sensing (SMMRS) is developed on the basis of the distribution characteristics of soil moisture in the NIR-red spectral reflectance space. Then, the SMMRS model is validated by comparison with field measured soil moisture data at different depths. The results showed that satellite estimated soil moisture by SMMRS is highly accordant with field measured data at 5 cm soil depth and average soil moisture at 0―20 cm soil depths, correlation coef- ficients are 0.80 and 0.87, respectively. This paper concludes that, being simple and effective, the SMMRS model has great potential to estimate surface moisture conditions.

  7. Composition Related Electrical Active Defect States of InGaAs and GaAsN

    Directory of Open Access Journals (Sweden)

    Arpad Kosa

    2017-01-01

    Full Text Available This paper discusses results of electrically active defect states - deep energy level analysis in InGaAs and GaAsN undoped semiconductor structures grown for solar cell applications. Main attention is focused on composition and growth condition dependent impurities and the investigation of their possible origins. For this purpose a widely utilized spectroscopy method, Deep Level Transient Fourier Spectroscopy, was utilized. The most significant responses of each sample labelled as InG2, InG3 and NG1, NG2 were discussed in detail and confirmed by simulations and literature data. The presence of a possible dual conduction type and dual state defect complex, dependent on the In/N composition, is reported. Beneficial characteristics of specific indium and nitrogen concentrations capable of eliminating or reducing certain point defects and dislocations are stated.

  8. Spin dynamics of heavy-holes in (InGa)As quantum dots

    Energy Technology Data Exchange (ETDEWEB)

    Dahbashi, Ramin; Wiegand, Julia; Huebner, Jens; Oestreich, Michael [Insitute for Solid State Physics, Leibniz Universitaet Hannover, Appelstr. 2, D-30167 Hannover (Germany); Marie, Xavier [Universite de Toulouse, INSA, UPS, CNRS, LPCNO, 135 avenue de Rangueil, F-31077 Toulouse (France); Pierz, Klaus; Schumacher, Hans Werner [Physikalisch Technische Bundesanstalt, Bundesallee 100, D-38116 Braunschweig (Germany)

    2013-07-01

    The spin dynamics of heavy-holes confined in (InGa)As quantum dots (QDs) are of particular interest for future applications in solid state quantum information processing. We employ spin noise spectroscopy as a quantum non-demolition experiment to get access to the intrinsic spin dynamics. The spin noise method is transferred from ensembles of QDs to single dot heavy-hole measurements. Numerical simulations show an extremely long spin dephasing time if light absorption is negligible. The investigated QDs are characterized by polarization resolved photoluminescence measurements and via a Hanbury Brown-Twiss setup. The discharging of the QDs via Auger recombination due to residual light absorption is deactivated by co-pumping the dots with low intensity light.

  9. InGaAs PV Device Development for TPV Power Systems

    Science.gov (United States)

    Wilt, David M.; Fatemi, Navid S.; Hoffman, Richard W., Jr.; Jenkins, Phillip P.; Brinker, David J.; Scheiman, David; Lowe, Roland; Chubb, Donald

    1994-01-01

    lndium Gallium Arsenide (InGaAs) photovoltaic devices have been fabricated with bandgaps ranging from 0.75 eV to 0.60 eV on Indium Phosphide (InP) substrates. Reported efficiencies have been as high as 11.2% (AMO) for the lattice matched 0.75 eV devices. The 0.75 eV cell demonstrated 14.8% efficiency under a 1500 K blackbody with a projected efficiency of 29.3%. The lattice mismatched devices (0.66 and 0.60 eV) demonstrated measured efficiencies of 8% and 6% respectively under similar conditions. Low long wavelength response and high dark currents are responsible for the poor performance of the mismatched devices. Temperature coefficients have been measured and are presented for all of the bandgaps tested.

  10. High performance highly strained InGaAs quantum-well ridge waveguide lasers

    Institute of Scientific and Technical Information of China (English)

    QU Yi; J. X. Zhang; A. Uddin; S. M. Wang; M. Sadeghi; A. Larsson; BO Baoxue; LIU Guojun; JIANG Huilin

    2005-01-01

    Highly strained InGaAs ridge waveguide lasers were fabricated with pulsed anodic oxidation. The laser structure was grown by molecular beam epitaxy (MBE) system. The output powers up to 50 mW per facet in CW mode were reached at room temperature for the 4 μm stripe lasers. The threshold current density of 300 A/cm2 was achieved with 600 μm cavity length. The emission wavelength at 100 mA was 1.19 μm. The slope efficiency was 0.45 W/A in linear output region of light-current characteristics. The laser characteristic temperature was 129 K (20℃―100℃).

  11. Monte Carlo Simulations of Spin Transport in Nanoscale InGaAs Field Effect Transistors

    CERN Document Server

    Thorpe, B; Langbein, F; Schirmer, S

    2016-01-01

    By augmenting an in-house developed, experimentally verified Monte Carlo device simulator with a Bloch equation model with a spin-orbit interaction Hamiltonian accounting for Dresselhaus and Rashba couplings, we simulate electron spin transport in a \\SI{25}{nm} gate length InGaAs MOSFET. We observe non-uniform decay of the net magnetization between the source and gate electrodes and an interesting magnetization recovery effect due to spin refocusing induced by high electric field between the gate and drain electrodes. We demonstrate coherent control of the polarization vector of the drain current via the source-drain and gate voltages, and show that the magnetization of the drain current is sensitive to strain in the channel, suggesting that the device could act as a room-temperature nanoscale strain sensor.

  12. NIR Camera/spectrograph: TEQUILA

    Science.gov (United States)

    Ruiz, E.; Sohn, E.; Cruz-Gonzalez, I.; Salas, L.; Parraga, A.; Torres, R.; Perez, M.; Cobos, F.; Tejada, C.; Iriarte, A.

    1998-11-01

    We describe the configuration and operation modes of the IR camera/spectrograph called TEQUILA, based on a 1024X1024 HgCdTe FPA (HAWAII). The optical system will allow three possible modes of operation: direct imaging, low and medium resolution spectroscopy and polarimetry. The basic system is being designed to consist of the following: 1) A LN$_2$ dewar that allocates the FPA together with the preamplifiers and a 24 filter position cylinder. 2) Control and readout electronics based on DSP modules linked to a workstation through fiber optics. 3) An optomechanical assembly cooled to -30oC that provides an efficient operation of the instrument in its various modes. 4) A control module for the moving parts of the instrument. The opto-mechanical assembly will have the necessary provisions to install a scanning Fabry-Perot interferometer and an adaptive optics correction system. The final image acquisition and control of the whole instrument is carried out in a workstation to provide the observer with a friendly environment. The system will operate at the 2.1 m telescope at the Observatorio Astronomico Nacional in San Pedro Martir, B.C. (Mexico), and is intended to be a first-light instrument for the new 7.8 m Mexican Infrared-Optical Telescope (TIM).

  13. Vacuum packaging of InGaAs focal plane array with four-stage thermoelectric cooler

    Science.gov (United States)

    Mo, De-feng; Liu, Da-fu; Yang, Li-yi; Xu, Qin-fei; Li, Xue

    2013-09-01

    The InGaAs focal plane array (FPA) detectors, covering the near-infrared 1~2.4 μm wavelength range, have been developed for application in space-based spectroscopy of the Earth atmosphere. This paper shows an all-metal vacuum package design for area array InGaAs detector of 1024×64 pixels, and its architecture will be given. Four-stage thermoelectric cooler (TEC) is used to cool down the FPA chip. To acquire high heat dissipation for TEC's Joule-heat, tungsten copper (CuW80) and kovar (4J29) is used as motherboard and cavity material respectively which joined by brazing. The heat loss including conduction, convection and radiation is analyzed. Finite element model is established to analyze the temperature uniformity of the chip substrate which is made of aluminum nitride (AlN). The performance of The TEC with and without heat load in vacuum condition is tested. The results show that the heat load has little influence to current-voltage relationship of TEC. The temperature difference (ΔT) increases as the input current increases. A linear relationship exists between heat load and ΔT of the TEC. Theoretical analysis and calculation show that the heat loss of radiation and conduction is about 187 mW and 82 mW respectively. Considering the Joule-heat of readout circuit and the heat loss of radiation and conduction, the FPA for a 220 K operation at room temperature can be achieved. As the thickness of AlN chip substrate is thicker than 1 millimeter, the temperature difference can be less than 0.3 K.

  14. Ab initio modeling of vacancies, antisites, and Si dopants in ordered InGaAs

    Science.gov (United States)

    Wang, Jingyang; Lukose, Binit; Thompson, Michael O.; Clancy, Paulette

    2017-01-01

    In0.53Ga0.47As, a III-V compound semiconductor with high electron mobility, is expected to bring better performance than silicon in next-generation n-type MOSFET devices. However, one major challenge to its wide scale adoption is the difficulty of obtaining high enough dopant activation. For Si-doped InGaAs, the best current experimental result, involving 10 min of furnace annealing at temperatures above 700 °C, yields a free electron concentration of 1.4 ×1019 cm-3, a value that still falls short of requirement for practical applications. In this paper, we investigate the origin of low dopant activation in InGaAs by calculating formation energies for a wide variety of single point defects (Si substutionals, Si tetrahedral interstitials, vacancies, and antisites) in Si-doped In0.5Ga0.5As in a CuAu-I type crystal structure. We find that (1) a high electron concentration can only be achieved under In/Ga-poor growth conditions, while As-poor conditions inhibit n-type doping; and (2) in heavily n-doped samples, cation vacancies VIn/Ga-3 contribute the most to the compensation of excess Si donors via the Si III - VIII mechanism (III = In/Ga), thus becoming the limiting factor to higher dopant activation. Under the most favorable growth conditions for n-doping, we find the maximum carrier concentration to be 5.2 ×1018 cm-3 under thermal equilibrium, within an order of magnitude of the best experimental value.

  15. NIRS3: The Near Infrared Spectrometer on Hayabusa2

    Science.gov (United States)

    Iwata, Takahiro; Kitazato, Kohei; Abe, Masanao; Ohtake, Makiko; Arai, Takehiko; Arai, Tomoko; Hirata, Naru; Hiroi, Takahiro; Honda, Chikatoshi; Imae, Naoya; Komatsu, Mutsumi; Matsunaga, Tsuneo; Matsuoka, Moe; Matsuura, Shuji; Nakamura, Tomoki; Nakato, Aiko; Nakauchi, Yusuke; Osawa, Takahito; Senshu, Hiroki; Takagi, Yasuhiko; Tsumura, Kohji; Takato, Naruhisa; Watanabe, Sei-ichiro; Barucci, Maria Antonietta; Palomba, Ernesto; Ozaki, Masanobu

    2017-03-01

    NIRS3: The Near Infrared Spectrometer is installed on the Hayabusa2 spacecraft to observe the target C-type asteroid 162173 Ryugu at near infrared wavelengths of 1.8 to 3.2 μm. It aims to obtain reflectance spectra in order to detect absorption bands of hydrated and hydroxide minerals in the 3 μm-band. We adopted a linear-image sensor with indium arsenide (InAs) photo diodes and a cooling system with a passive radiator to achieve an optics temperature of 188 K ( -85°C), which enables to retaining sufficient sensitivity and noise level in the 3 μm wavelength region. We conducted ground performance tests for the NIRS3 flight model (FM) to confirm its baseline specifications. The results imply that the properties such as the signal-to-noise ratio (SNR) conform to scientific requirements to determine the degree of aqueous alteration, such as CM or CI chondrite, and the stage of thermal metamorphism on the asteroid surface.

  16. NIRS3: The Near Infrared Spectrometer on Hayabusa2

    Science.gov (United States)

    Iwata, Takahiro; Kitazato, Kohei; Abe, Masanao; Ohtake, Makiko; Arai, Takehiko; Arai, Tomoko; Hirata, Naru; Hiroi, Takahiro; Honda, Chikatoshi; Imae, Naoya; Komatsu, Mutsumi; Matsunaga, Tsuneo; Matsuoka, Moe; Matsuura, Shuji; Nakamura, Tomoki; Nakato, Aiko; Nakauchi, Yusuke; Osawa, Takahito; Senshu, Hiroki; Takagi, Yasuhiko; Tsumura, Kohji; Takato, Naruhisa; Watanabe, Sei-ichiro; Barucci, Maria Antonietta; Palomba, Ernesto; Ozaki, Masanobu

    2017-07-01

    NIRS3: The Near Infrared Spectrometer is installed on the Hayabusa2 spacecraft to observe the target C-type asteroid 162173 Ryugu at near infrared wavelengths of 1.8 to 3.2 μm. It aims to obtain reflectance spectra in order to detect absorption bands of hydrated and hydroxide minerals in the 3 μm-band. We adopted a linear-image sensor with indium arsenide (InAs) photo diodes and a cooling system with a passive radiator to achieve an optics temperature of 188 K (-85°C), which enables to retaining sufficient sensitivity and noise level in the 3 μm wavelength region. We conducted ground performance tests for the NIRS3 flight model (FM) to confirm its baseline specifications. The results imply that the properties such as the signal-to-noise ratio (SNR) conform to scientific requirements to determine the degree of aqueous alteration, such as CM or CI chondrite, and the stage of thermal metamorphism on the asteroid surface.

  17. Design of NIR Chromenylium-Cyanine Fluorophore Library for "Switch-ON" and Ratiometric Detection of Bio-Active Species In Vivo.

    Science.gov (United States)

    Wei, Yanfen; Cheng, Dan; Ren, Tianbing; Li, Yinhui; Zeng, Zebing; Yuan, Lin

    2016-02-02

    The real-time monitoring of key biospecies in the living systems has received thrusting attention during the past decades. Specifically, fluorescent detection based on near-infrared (NIR) fluorescent probes is highly favorable for live cells, live tissues, and even animal imaging, owing to the substantial merits of the NIR window, such as minimal phototoxicity, deep penetration into tissues, and low autofluorescence background. Nevertheless, developing potent NIR fluorescent probes still poses serious challenges to the chemists because traditional NIR fluorophores are less tunable than visible-wavelength fluorophores. To address this issue, here we report a set of novel NIR hybrid fluorophores, namely, the hybrid chromenylium-cyanine fluorophore (CC-Fluor), in which both the fluorescence intensity and the emission wavelength can be easily adjusted by the conformational changes and substitution groups. Compared to known NIR fluorophores, the new CC-Fluors are substantially advantageous for NIR probe development: (1) CC-Fluors display tunable and moderate Stokes shifts and quantum yields; (2) the fluorophores are stable at physiological conditions after long-term incubation; (3) the absorption maxima of CC-Fluors coincide with the common laser spectral lines in mainstream in vivo imaging systems; (4) most importantly, CC-Fluors can be easily modified to prepare NIR probes targeting various biospecies. To fully demonstrate the practical utility of CC-Fluors, we report two innovative NIR probes, a ratiometric pH probe and a turn-on Hg(2+) probe, both are successfully employed in live animal imaging. Hence, the detailed studies allow us to confirm that CC-Fluors can work as an excellent platform for developing NIR probes for the detection of species in living systems.

  18. Cancer-targeted near infrared imaging using rare earth ion-doped ceramic nanoparticles.

    Science.gov (United States)

    Zako, Tamotsu; Yoshimoto, Miya; Hyodo, Hiroshi; Kishimoto, Hidehiro; Ito, Masaaki; Kaneko, Kazuhiro; Soga, Kohei; Maeda, Mizuo

    2015-01-01

    The use of near-infrared (NIR) light over 1000 nm (OTN-NIR or second NIR) is advantageous for bioimaging because it enables deep tissue penetration due to low scattering and autofluorescence. In this report, we describe the application of rare earth ion-doped ceramic nanoparticles to cancer-targeted NIR imaging using erbium and ytterbium ion-doped yttrium oxide nanoparticles (YNP) functionalized with streptavidin via bi-functional PEG (SA-YNP). YNP has NIR emission at 1550 nm, with NIR excitation at 980 nm (NIR-NIR imaging). Cancer-specific NIR-NIR imaging was demonstrated using SA-YNP and biotinylated antibodies on cancer cells and human colon cancer tissues. NIR-NIR imaging through porcine meat of 1 cm thickness was also demonstrated, supporting the possible application of deep tissue NIR-NIR bioimaging using YNP as a probe. Our results suggest that non-invasive imaging using YNP has great potential for general application in cancer imaging in living subjects.

  19. Impact of La{sub 2}O{sub 3} interfacial layers on InGaAs metal-oxide-semiconductor interface properties in Al{sub 2}O{sub 3}/La{sub 2}O{sub 3}/InGaAs gate stacks deposited by atomic-layer-deposition

    Energy Technology Data Exchange (ETDEWEB)

    Chang, C.-Y., E-mail: cychang@mosfet.t.u-tokyo.ac.jp; Takenaka, M.; Takagi, S. [Department of Electrical Engineering and Information Systems, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0032 (Japan); JST-CREST, K' s Gobancho, 7 Gobancho, Chiyoda-ku, Tokyo 102-0076 (Japan); Ichikawa, O.; Osada, T.; Hata, M.; Yamada, H. [JST-CREST, K' s Gobancho, 7 Gobancho, Chiyoda-ku, Tokyo 102-0076 (Japan); Sumitomo Chemical Co. Ltd., 6 Kitahara, Tsukuba, Ibaraki 300-3294 (Japan)

    2015-08-28

    We examine the electrical properties of atomic layer deposition (ALD) La{sub 2}O{sub 3}/InGaAs and Al{sub 2}O{sub 3}/La{sub 2}O{sub 3}/InGaAs metal-oxide-semiconductor (MOS) capacitors. It is found that the thick ALD La{sub 2}O{sub 3}/InGaAs interface provides low interface state density (D{sub it}) with the minimum value of ∼3 × 10{sup 11} cm{sup −2} eV{sup −1}, which is attributable to the excellent La{sub 2}O{sub 3} passivation effect for InGaAs surfaces. It is observed, on the other hand, that there are a large amount of slow traps and border traps in La{sub 2}O{sub 3}. In order to simultaneously satisfy low D{sub it} and small hysteresis, the effectiveness of Al{sub 2}O{sub 3}/La{sub 2}O{sub 3}/InGaAs gate stacks with ultrathin La{sub 2}O{sub 3} interfacial layers is in addition evaluated. The reduction of the La{sub 2}O{sub 3} thickness to 0.4 nm in Al{sub 2}O{sub 3}/La{sub 2}O{sub 3}/InGaAs gate stacks leads to the decrease in hysteresis. On the other hand, D{sub it} of the Al{sub 2}O{sub 3}/La{sub 2}O{sub 3}/InGaAs interfaces becomes higher than that of the La{sub 2}O{sub 3}/InGaAs ones, attributable to the diffusion of Al{sub 2}O{sub 3} through La{sub 2}O{sub 3} into InGaAs and resulting modification of the La{sub 2}O{sub 3}/InGaAs interface structure. As a result of the effective passivation effect of La{sub 2}O{sub 3} on InGaAs, however, the Al{sub 2}O{sub 3}/10 cycle (0.4 nm) La{sub 2}O{sub 3}/InGaAs gate stacks can realize still lower D{sub it} with maintaining small hysteresis and low leakage current than the conventional Al{sub 2}O{sub 3}/InGaAs MOS interfaces.

  20. Near-infrared (NIR) emitting conjugated polymers for biomedical applications (Presentation Recording)

    Science.gov (United States)

    Repenko, Tatjana; Kuehne, Alexander J. C.

    2015-10-01

    Fluorescent biomedical markers of today such as dye-infiltrated colloids, microgels and quantum dots suffer from fast bleaching, lack surface functionality (for targets or pharmaceutical agents) and potentially leach heavy metals in case of quantum dots (e.g. Cd). By contrast, conjugated polymer particles are non-cytotoxic, exhibit reduced bleaching, as the entire particle consists of fluorophore, they are hydrophobic and show high quantum yields. Consequently, conjugated polymer particles represent ideal materials for biological applications and imaging. However currently, conjugated polymer particles for biomedical imaging usually lack near-infrared (NIR) emission and are polydisperse. Fluorescent agents with emission in the NIR spectrum are interesting for biomedical applications due to their low photo-damage towards biological species and the ability of NIR radiation to penetrate deep into biological tissue.. I will present the development and synthesis of new conjugated polymers particles with fluorescence in the NIR spectral region for bio-imaging and clinical diagnosis. The particle synthesis proceeds in a one-step Pd or Ni-catalyzed dispersion polymerization of functional NIR emitters. The resulting monodisperse conjugated polymer particles are obtained as a dispersion in a non-hazardous solvent. Different sizes in the sub-micrometer range with a narrow size distribution can be produced. Furthermore biological recognition motifs can be easily attached to the conjugated polymers via thiol-yne click-chemistry providing specific tumor targeting without quenching of the fluorescence. References [1] Kuehne AJC, Gather MC, Sprakel J., Nature Commun. 2012, 3, 1088. [2] Repenko T, Fokong S, De Laporte L, Go D, Kiessling F, Lammers T, Kuehne AJC.,Chem Commun 2015, accepted.

  1. Nanoscale imaging of the photoresponse in PN junctions of InGaAs infrared detector

    Science.gov (United States)

    Xia, Hui; Li, Tian-Xin; Tang, Heng-Jing; Zhu, Liang; Li, Xue; Gong, Hai-Mei; Lu, Wei

    2016-01-01

    Electronic layout, such as distributions of charge carriers and electric field, in PN junction is determinant for the photovoltaic devices to realize their functionality. Considerable efforts have been dedicated to the carrier profiling of this specific region with Scanning Probe Microscope, yet reliable analysis was impeded by the difficulty in resolving carriers with high mobility and the unclear surface effect, particularly on compound semiconductors. Here we realize nanometer Scanning Capacitance Microscopic study on the cross-section of InGaAs/InP photodetctors with the featured dC/dV layout of PN junction unveiled for the first time. It enables us to probe the photo-excited minority carriers in junction region and diagnose the performance deficiency of the diode devices. This work provides an illuminating insight into the PN junction for assessing its basic capability of harvesting photo-carriers as well as blocking leakage current in nanoscopic scale. PMID:26892069

  2. Nanoscale imaging of the photoresponse in PN junctions of InGaAs infrared detector

    Science.gov (United States)

    Xia, Hui; Li, Tian-Xin; Tang, Heng-Jing; Zhu, Liang; Li, Xue; Gong, Hai-Mei; Lu, Wei

    2016-02-01

    Electronic layout, such as distributions of charge carriers and electric field, in PN junction is determinant for the photovoltaic devices to realize their functionality. Considerable efforts have been dedicated to the carrier profiling of this specific region with Scanning Probe Microscope, yet reliable analysis was impeded by the difficulty in resolving carriers with high mobility and the unclear surface effect, particularly on compound semiconductors. Here we realize nanometer Scanning Capacitance Microscopic study on the cross-section of InGaAs/InP photodetctors with the featured dC/dV layout of PN junction unveiled for the first time. It enables us to probe the photo-excited minority carriers in junction region and diagnose the performance deficiency of the diode devices. This work provides an illuminating insight into the PN junction for assessing its basic capability of harvesting photo-carriers as well as blocking leakage current in nanoscopic scale.

  3. Nanoscale imaging of the photoresponse in PN junctions of InGaAs infrared detector.

    Science.gov (United States)

    Xia, Hui; Li, Tian-Xin; Tang, Heng-Jing; Zhu, Liang; Li, Xue; Gong, Hai-Mei; Lu, Wei

    2016-01-01

    Electronic layout, such as distributions of charge carriers and electric field, in PN junction is determinant for the photovoltaic devices to realize their functionality. Considerable efforts have been dedicated to the carrier profiling of this specific region with Scanning Probe Microscope, yet reliable analysis was impeded by the difficulty in resolving carriers with high mobility and the unclear surface effect, particularly on compound semiconductors. Here we realize nanometer Scanning Capacitance Microscopic study on the cross-section of InGaAs/InP photodetectors with the featured dC/dV layout of PN junction unveiled for the first time. It enables us to probe the photo-excited minority carriers in junction region and diagnose the performance deficiency of the diode devices. This work provides an illuminating insight into the PN junction for assessing its basic capability of harvesting photo-carriers as well as blocking leakage current in nanoscopic scale.

  4. Design and construction of a NIR spectrometer

    CERN Document Server

    Barcala-Riveira, J M; Fernandez-Marron, J L; Molero-Menendez, F; Navarrete-Marin, J J; Oller-Gonzalez, J C

    2003-01-01

    This document describes the design and construction of a NIR spectrometer based on an acoustic-optic tunable filter. The spectrometer will be used for automatic identification of plastics in domestic waste. The system works between 1200 and 1800 nm. Instrument is controlled by a personal computer. Computer receives and analyses data. A software package has been developed to do these tasks. (Author) 27 refs.

  5. NIR sensitivity analysis with the VANE

    Science.gov (United States)

    Carrillo, Justin T.; Goodin, Christopher T.; Baylot, Alex E.

    2016-05-01

    Near infrared (NIR) cameras, with peak sensitivity around 905-nm wavelengths, are increasingly used in object detection applications such as pedestrian detection, occupant detection in vehicles, and vehicle detection. In this work, we present the results of simulated sensitivity analysis for object detection with NIR cameras. The analysis was conducted using high performance computing (HPC) to determine the environmental effects on object detection in different terrains and environmental conditions. The Virtual Autonomous Navigation Environment (VANE) was used to simulate highresolution models for environment, terrain, vehicles, and sensors. In the experiment, an active fiducial marker was attached to the rear bumper of a vehicle. The camera was mounted on a following vehicle that trailed at varying standoff distances. Three different terrain conditions (rural, urban, and forest), two environmental conditions (clear and hazy), three different times of day (morning, noon, and evening), and six different standoff distances were used to perform the sensor sensitivity analysis. The NIR camera that was used for the simulation is the DMK firewire monochrome on a pan-tilt motor. Standoff distance was varied along with environment and environmental conditions to determine the critical failure points for the sensor. Feature matching was used to detect the markers in each frame of the simulation, and the percentage of frames in which one of the markers was detected was recorded. The standoff distance produced the biggest impact on the performance of the camera system, while the camera system was not sensitive to environment conditions.

  6. Distraction decreases prefrontal oxygenation: A NIRS study.

    Science.gov (United States)

    Ozawa, Sachiyo; Hiraki, Kazuo

    2017-04-01

    When near-infrared spectroscopy (NIRS) is used to measure emotion-related cerebral blood flow (CBF) changes in the prefrontal cortex regions, the functional distinction of CBF changes is often difficult because NIRS is unable to measure neural activity in deeper brain regions that play major roles in emotional processing. The CBF changes could represent cognitive control of emotion and emotional responses to emotional materials. Supposing that emotion-related CBF changes in the prefrontal cortex regions during distraction are emotional responses, we examined whether oxygenated hemoglobin (oxyHb) decreases. Attention-demanding tasks cause blood flow decreases, and we thus compared the effects of visually paced tapping with different tempos, on distraction. The results showed that the oxyHb level induced by emotional stimulation decreased with fast-tempo tapping significantly more than slow-tempo tapping in ventral medial prefrontal cortex regions. Moreover, a Global-Local task following tapping showed significantly greater local-minus-global response time (RT) difference scores in the fast- and mid-tempo condition compared with those in the slow-tempo, suggesting an increased attentional focus, and decreased negative emotion. The overall findings indicate that oxyHb changes in a relatively long distraction task, as measured by NIRS, are associated with emotional responses, and oxyHb can be decreased by successfully performing attention-demanding distraction tasks.

  7. Testing of InGaAs, microbolometer and pyroelectric detectors in support of the EarthCARE mission

    Science.gov (United States)

    Hopkinson, Gordon; Gomez Rojas, Luis; Skipper, Mark; Meynart, Roland

    2008-10-01

    A test programme for infrared detectors in support of the EarthCARE mission is discussed. Commercially available linear InGaAs arrays from XenICs, Belgium (cut-off wavelengths 1.7, 2.2 and 2.5 μm), 384 x 288 amorphous silicon microbolometer arrays from ULIS, France and un-windowed single element lithium tantalate pyroelectric detectors from Infratec, Germany have been studied in detail to assess their suitability for EarthCARE and to provide performance data to aid in the design of the flight instruments. Tests included radiation resistance (cobalt60 and 60 MeV protons plus a heavy ion latch-up test for the InGaAs and microbolometer arrays), dark signal, noise, output stability, linearity, crosstalk and spectral response. In addition, the pyroelectric detectors were tested for low microphony.

  8. Effects of an InGaAs Cap Layer on the Optical Properties of InAs Quantum Dot Molecules

    Institute of Scientific and Technical Information of China (English)

    TIAN Peng; HUANG Li-Rong; YUAN Xiu-Hua; HUANG De-Xiu

    2011-01-01

    @@ Self-assembled InAs quantum dot molecules are grown on GaAs substrates without following any special protocols by using metal-organic chemical vapor deposition.The effects of indium composition and the thickness of the InGaAs cap layer on the optical properties of InAs quantum dot molecules are investigated by photoluminescence.With increasing indium composition and thickness of the InGaAs cap layer, the ground-state wavelength of the emission spectrum redshifts and the peak intensity decreases.In addition, the structural and optical properties of quantum dots and quantum dot molecules are comparatively studied, and the results show that when quantum dots turn into quantum dot molecules, the emission wavelength red shifts.

  9. Interface Defect Hydrogen Depassivation and Capacitance-Voltage Hysteresis of Al2O3/InGaAs Gate Stacks.

    Science.gov (United States)

    Tang, Kechao; Palumbo, Felix Roberto; Zhang, Liangliang; Droopad, Ravi; McIntyre, Paul C

    2017-03-01

    We investigate the effects of pre- and postatomic layer deposition (ALD) defect passivation with hydrogen on the trap density and reliability of Al2O3/InGaAs gate stacks. Reliability is characterized by capacitance-voltage hysteresis measurements on samples prepared using different fabrication procedures and having different initial trap densities. Despite its beneficial capability to passivate both interface and border traps, a final forming gas (H2/N2) anneal (FGA) step is correlated with a significant hysteresis. This appears to be caused by hydrogen depassivation of defects in the gate stack under bias stress, supported by the observed bias stress-induced increase of interface trap density, and strong hydrogen isotope effects on the measured hysteresis. On the other hand, intentional air exposure of the InGaAs surface prior to Al2O3 ALD increases the initial interface trap density (Dit) but considerably lowers the hysteresis.

  10. Suppressing inflammation from inside out with novel NIR visible perfluorocarbon nanotheranostics

    Science.gov (United States)

    Janjic, Jelena M.; Patel, Sravan K.; Patrick, Michael J.; Pollock, John A.; DiVito, Erin; Cascio, Michael

    2013-02-01

    Highly innovative multimodal perfluorocarbon (PFC) nanoemulsions are presented. They serve simultaneously as dual-mode imaging reagents (NIR and 19F MRI), and drug delivery vehicles for water insoluble cyclooxgenase-2 (COX-2) inhibitors. These features qualify them as theranostic. Cancer progression and metastasis are highly influenced by tumor microenvironment and inflammation. Infiltration of primary tumors with inflammation-promoting cells (e.g. macrophages) is a negative prognostic factor for cancer patient survival. We postulate that the suppression of COX-2 enzyme in macrophages by theranostic PFC nanoemulsions will result in changes in macrophage levels of accumulation in tumors and/or their phenotype, which can suppress tumor- promoting activity. The presented theranostic nanoemulsions are designed to label immune cells such as macrophages, and deliver celecoxib, a COX-2 inhibitor. The designed theranostic incorporates two fluorescent reporters: a near-infrared (NIR) fluorescent dye for improved optical in vivo imaging, and a distinct fluorescent dye for histological analysis of excised tissues. A high content of PFC in the theranostic allows 19F MRI to quantitatively assess the distribution of the injected nanomedicine in the peritumoral area, and measure tumor-associated inflammation, while 1H MRI provides anatomical context. NIR imaging is used as a complementary in vivo technique to assess biodistribution of the theranostic. We report preparation and characterization of the nanoemulsions' colloidal and optical stability, in vitro toxicity, and imaging capabilities. This theranostic offers flexibility for in vitro and in vivo inflammation imaging and histological analysis using three different imaging functionalities (fluorescence, NIR and 19F MRI), advancing the monitoring and modulating of tumor-infiltrating immune cells in vivo.

  11. Disentangling the NIR/optical emission of the black hole XTE J1650-500 during outburst

    CERN Document Server

    Curran, P A; Heras, J A Zurita

    2012-01-01

    While the sources of X-ray and radio emission in the different states of low-mass X-ray binaries are relatively well understood, the origin of the near-infrared (NIR) and optical emission is more often debated. It is likely that the NIR/optical flux originates from an amalgam of different emission regions, because it occurs at the intersecting wavelengths of multiple processes. We aim to identify the NIR/optical emission region(s) of one such low-mass X-ray binary and black hole candidate, XTE J1650-500, via photometric, timing, and spectral analyses. We present unique NIR/optical images and spectra, obtained with the ESO-New Technology Telescope, during the peak of the 2001 outburst of XTE J1650-500. The data suggest that the NIR/optical flux is due to a combination of emission mechanisms including a significant contribution from X-ray reprocessing and, at early times in the hard state, a relativistic jet that is NIR/radio dim compared to similar sources.The jet of XTE J1650-500 is relatively weak compared t...

  12. Segregated Optical-NIR colour distributions of MDS galaxies

    CERN Document Server

    Ferreras, I; Martínez-González, E; Benítez, N

    1998-01-01

    We present a K survey of 29 fields covering approximately 90 arcmin^2 from the Medium Deep Survey (MDS) catalogue down to a completeness magnitude of K=18.0 (limiting magnitude K=19.0). The morphology obtained by the MDS team using high resolution images from HST/WFPC2 along with our NIR observations allow a Colour-Magnitude and Colour-Colour analysis that agrees in general with spectral evolution models (Bruzual & Charlot 1998) especially if a reasonable range of metallicities for the Simple Stellar Populations used (0.2 4.5, setting an upper limit to the number density of EROs at dn_{EROs}/dØmega < 0.011 arcmin^{-2} (K < 18.0).

  13. Absorption Coefficient of InGaAs V-shaped Quantum Wires Integrated in Optical Waveguides by MBE Growth

    Science.gov (United States)

    1998-06-01

    Integrated in Optical Waveguides by MBE Growth DISTRIBUTION: Approved for public release, distribution unlimited Availability: Hard copy only. This...coefficient of InGaAs V-shaped quantum wires integrated in optical waveguides by MBE growth F Filipowitzt, C. Gourgont, D. Martint, Y Magnenatt, P. Giaccarit...observation The fabrication of waveguides that contains QWR consists of three process sequences: (i) MBE growth of the lower waveguide cladding and half of the

  14. Temperature dependence of trapping effects in metal gates/Al2O3/InGaAs stacks

    Science.gov (United States)

    Palumbo, F.; Pazos, S.; Aguirre, F.; Winter, R.; Krylov, I.; Eizenberg, M.

    2017-06-01

    The influence of the temperature on Metal Gate/Al2O3/n-InGaAs stacks has been studied by means of capacitance-voltage (C-V) hysteresis and flat band voltage as function of both negative and positive stress fields. It was found that the de-trapping effect decreases at low-temperature, indicating that the de-trapping of trapped electrons from oxide traps may be performed via Al2O3/InGaAs interface defects. The dependence of the C-V hysteresis on the stress field at different temperatures in our InGaAs stacks can be explained in terms of the defect spatial distribution. An oxide defect distribution can be found very close to the metal gate/Al2O3 interface. On the other side, the Al2O3/InGaAs interface presents defects distributed from the interface into the bulk of the oxide, showing the influence of InGaAs on Al2O3 in terms of the spatial defect distribution. At the present, he is a research staff of the National Council of Science and Technology (CONICET), working in the National Commission of Atomic Energy (CNEA) in Buenos Aires, Argentina, well embedded within international research collaboration. Since 2008, he is Professor at the National Technological University (UTN) in Buenos Aires, Argentina. Dr. Palumbo has received research fellowships from: Marie Curie Fellowship within the 7th European Community Framework Programme, Abdus Salam International Centre for Theoretical Physics (ICTP) Italy, National Council of Science and Technology (CONICET) Argentina, and Consiglio Nazionale delle Ricerche (CNR) Italy. He is also a frequent scientific visitor of academic institutions as IMM-CNR-Italy, Minatec Grenoble-France, the Autonomous University of Barcelona-Spain, and the Israel Institute of Technology-Technion. He has authored and co-authored more than 50 papers in international conferences and journals.

  15. Metamorphic InGaAs quantum wells for light emission at 1.3-1.6 {mu}m

    Energy Technology Data Exchange (ETDEWEB)

    Wang, S.M. [Department of Microtechnology and Nanoscience, Chalmers University of Technology, 41296 Goeteborg (Sweden)]. E-mail: shumin.wang@mc2.chalmers.se; Tangring, I. [Department of Microtechnology and Nanoscience, Chalmers University of Technology, 41296 Goeteborg (Sweden); Gu, Q.F. [Department of Microtechnology and Nanoscience, Chalmers University of Technology, 41296 Goeteborg (Sweden); Sadeghi, M. [Department of Microtechnology and Nanoscience, Chalmers University of Technology, 41296 Goeteborg (Sweden); Larsson, A. [Department of Microtechnology and Nanoscience, Chalmers University of Technology, 41296 Goeteborg (Sweden); Wang, X.D. [Engineering Research Center for Semiconductor Integrated Technology, Institute of Semiconductors, Chinese Academy of Sciences, P. O. Box 912, 100083 Beijing (China); Ma, C.H. [Engineering Research Center for Semiconductor Integrated Technology, Institute of Semiconductors, Chinese Academy of Sciences, P. O. Box 912, 100083 Beijing (China); Buyanova, I.A. [Department of Physics and Measurement Technology, Linkoeping University, 58183 Linkoeping (Sweden); Chen, W.M. [Department of Physics and Measurement Technology, Linkoeping University, 58183 Linkoeping (Sweden)

    2007-03-26

    Metamorphic InGaAs quantum well structures grown on GaAs reveal strong light emission at 1.3-1.6 {mu}m, smooth surface with an average roughness below 2 nm and good rectifying I-V characteristics. Dark line defects are found in the QW. Post growth thermal annealing further improves the luminescence efficiency but does not remove those dark line defects. Some challenges of epitaxial growth using this method for laser applications are discussed.

  16. High-Performance Wrap-Gated InGaAs Nanowire Field-Effect Transistors with Sputtered Dielectrics

    OpenAIRE

    Li-Fan Shen; SenPo Yip; Zai-xing Yang; Ming Fang; TakFu Hung; Pun, Edwin Y. B.; Ho, Johnny C.

    2015-01-01

    Although wrap-gated nanowire field-effect-transistors (NWFETs) have been explored as an ideal electronic device geometry for low-power and high-frequency applications, further performance enhancement and practical implementation are still suffering from electron scattering on nanowire surface/interface traps between the nanowire channel and gate dielectric as well as the complicated device fabrication scheme. Here, we report the development of high-performance wrap-gated InGaAs NWFETs using c...

  17. Research data supporting "InGaAs spin light emitting diodes measured in the Faraday and oblique Hanle geometries"

    OpenAIRE

    Mansell, R; Laloë, J-B.; Holmes, S. N.; Petrou, A.; Farrer, I.; Jones, G. A. C.; Ritchie, D A; Barnes, C. H. W.

    2016-01-01

    Supporting data for 'InGaAs spin light emitting diodes measured in the Faraday and oblique Hanle geometries' published as JPhysD 49 165103 (2016). Contains underlying data for figures 1 and 3. This research data supports “InGaAs spin light emitting diodes measured in the Faraday and oblique Hanle geometries” which has been published in “Journal of Physics D: Applied Physics”. This work was supported by the EPSRC [grant number EPSRC DTA award].

  18. Carrier dynamics of strain-engineered InAs quantum dots with (In)GaAs surrounding material

    Science.gov (United States)

    Nasr, O.; Chauvin, N.; Alouane, M. H. Hadj; Maaref, H.; Bru-Chevallier, C.; Sfaxi, L.; Ilahi, B.

    2017-02-01

    The present study reports on the optical properties of epitaxially grown InAs quantum dots (QDs) inserted within an InGaAs strain-reducing layer (SRL). The critical energy states in such QD structures have been identified by combining photoluminescence (PL) and photoluminescence of excitation (PLE) measurements. Carrier lifetime is investigated by time-resolved photoluminescence (TRPL), allowing us to study the impact of the composition of the surrounding materials on the QD decay time. Results showed that covering the InAs QDs with, or embedding them within, an InGaAs SRL increases the carrier dynamics, while a shorter carrier lifetime has been observed when they are grown on top of an InGaAs SRL. Investigation of the dependence of carrier lifetime on temperature showed good stability of the decay time, deduced from the consequences of improved QD confinement. The findings suggest that embedding or capping the QDs with SRL exerts optimization of their room temperature optical properties.

  19. Pharmaceutical applications using NIR technology in the cloud

    Science.gov (United States)

    Grossmann, Luiz; Borges, Marco A.

    2017-05-01

    NIR technology has been available for a long time, certainly more than 50 years. Without any doubt, it has found many niche applications, especially in the pharmaceutical, food, agriculture and other industries due to its flexibility. There are a number of advantages over other existing analytical technologies we can list, for example virtually no need for sample preparation; usually NIR does not demand sample destruction and subsequent discard; NIR provides fast results; NIR does not require extensive operator training and carries small operating costs. However, the key point about NIR technology is the fact that it's more related to statistics than chemistry or, in other words, we are more concerned about analyzing and distinguishing features within the data than looking deep into the chemical entities themselves. A simple scan reading in the NIR range usually involves huge inflows of data points. Usually we decompose the signals into hundreds of predictor variables and use complex algorithms to predict classes or quantify specific content. NIR is all about math, especially by converting chemical information into numbers. Easier said than done. A NIR signal is a very complex one. Usually the signal responses are not specific to a particular material, rather, each grouṕs responses add up, thus providing low specificity of a spectral reading. This paper proposes a simple and efficient method to analyze and compare NIR spectra for the purpose of identifying the presence of active pharmaceutical ingredients in finished products using low cost NIR scanning devices connected to the internet cloud.

  20. On temporal connectivity of PFC via Gauss-Markov modeling of fNIRS signals.

    Science.gov (United States)

    Aydöre, Sergül; Mihçak, M Kivanç; Ciftçi, Koray; Akin, Ata

    2010-03-01

    Functional near-infrared spectroscopy (fNIRS) is an optical imaging method, which monitors the brain activation by measuring the successive changes in the concentration of oxy- and deoxyhemoglobin in real time. In this study, we present a method to investigate the functional connectivity of prefrontal cortex (PFC) Sby applying a Gauss-Markov model to fNIRS signals. The hemodynamic changes on PFC during the performance of cognitive paradigm are measured by fNIRS for 17 healthy adults. The color-word matching Stroop task is performed to activate 16 different regions of PFC. There are three different types of stimuli in this task, which can be listed as incongruent stimulus (IS), congruent stimulus (CS), and neutral stimulus (NS), respectively. We introduce a new measure, called "information transfer metric" (ITM) for each time sample. The behavior of ITMs during IS are significantly different from the ITMs during CS and NS, which is consistent with the outcome of the previous research, which concentrated on fNIRS signal analysis via color-word matching Stroop task. Our analysis shows that the functional connectivity of PFC is highly relevant with the cognitive load, i.e., functional connectivity increases with the increasing cognitive load.

  1. Single-trial classification of NIRS signals during emotional induction tasks: towards a corporeal machine interface.

    Science.gov (United States)

    Tai, Kelly; Chau, Tom

    2009-11-09

    Corporeal machine interfaces (CMIs) are one of a few available options for restoring communication and environmental control to those with severe motor impairments. Cognitive processes detectable solely with functional imaging technologies such as near-infrared spectroscopy (NIRS) can potentially provide interfaces requiring less user training than conventional electroencephalography-based CMIs. We hypothesized that visually-cued emotional induction tasks can elicit forehead hemodynamic activity that can be harnessed for a CMI. Data were collected from ten able-bodied participants as they performed trials of positively and negatively-emotional induction tasks. A genetic algorithm was employed to select the optimal signal features, classifier, task valence (positive or negative emotional value of the stimulus), recording site, and signal analysis interval length for each participant. We compared the performance of Linear Discriminant Analysis and Support Vector Machine classifiers. The latency of the NIRS hemodynamic response was estimated as the time required for classification accuracy to stabilize. Baseline and activation sequences were classified offline with accuracies upwards of 75.0%. Feature selection identified common time-domain discriminatory features across participants. Classification performance varied with the length of the input signal, and optimal signal length was found to be feature-dependent. Statistically significant increases in classification accuracy from baseline rates were observed as early as 2.5 s from initial stimulus presentation. NIRS signals during affective states were shown to be distinguishable from baseline states with classification accuracies significantly above chance levels. Further research with NIRS for corporeal machine interfaces is warranted.

  2. Transcriptional analysis of the nirS gene, encoding cytochrome cd1 nitrite reductase, of Paracoccus pantotrophus LMD 92.63.

    Science.gov (United States)

    Saunders, N F; Ferguson, S J; Baker, S C

    2000-02-01

    The gene for cytochrome cd1 nitrite reductase of Paracoccus pantotrophus, a protein of known crystal structure, is nirS. This gene is shown to be flanked by genes previously recognized in other organisms to encode proteins involved in the control of its transcription (nirI) and the biosynthesis of the d1 cofactor (nirE). Northern blot analysis has established under anaerobic conditions that a monocistronic transcript is produced from nirS, in contrast to observations with other denitrifying bacteria in which arrangement of flanking genes is different and the messages produced are polycistronic. The lack of a transcript under aerobic conditions argues against a role for cytochrome cd1 in the previously proposed aerobic denitrification pathway in Pa. pantotrophus. A putative rho-independent transcription termination sequence immediately following nirS, and preceding nirE, can be identified. The independent transcription of nirS and nirE indicates that it should be possible to produce site-directed mutants of nirS borne on a plasmid in a nirS deletion mutant. The transcript start point for nirS has been determined by two complementary techniques, 5'-RACE (Rapid amplification of cDNA 5' ends) and primer extension. It is 29 bp upstream of the AUG of nirS. An anaerobox, which presumably binds Nnr, is centred a further 41.5 bp upstream of the transcript start. No standard sigma70 DNA sequence motifs can be identified, but a conserved sequence (T-T-GIC-C-G/C-G/C) can be found in approximately the same position (-16) upstream of the transcript starts of nirS and nirI, whose products are both involved in the conversion of nitrite to nitric oxide.

  3. A Multifunctional Biomaterial with NIR Long Persistent Phosphorescence, Photothermal Response and Magnetism.

    Science.gov (United States)

    Wu, Yiling; Li, Yang; Qin, Xixi; Qiu, Jianrong

    2016-09-20

    There are many reports on long persistent phosphors (LPPs) applied in bioimaging. However, there are few reports on LPPs applied in photothermal therapy (PTT), and an integrated system with multiple functions of diagnosis and therapy. In this work, we fabricate effective multifunctional phosphors Zn3 Ga2 SnO8 : Cr(3+) , Nd(3+) , Gd(3+) with NIR persistent phosphorescence, photothermal response and magnetism. Such featured materials can act as NIR optical biolabels and magnetic resonance imaging (MRI) contrast agents for tracking the early cancer cells, but also as photothermal therapeutic agent for killing the cancer cells. This new multifunctional biomaterial is expected to open a new possibility of setting up an advanced imaging-guided therapy system featuring a high resolution for bioimaging and low side effects for the photothermal ablation of tumors.

  4. A brief review on the history of human functional near-infrared spectroscopy (fNIRS) development and fields of application.

    Science.gov (United States)

    Ferrari, Marco; Quaresima, Valentina

    2012-11-01

    This review is aimed at celebrating the upcoming 20th anniversary of the birth of human functional near-infrared spectroscopy (fNIRS). After the discovery in 1992 that the functional activation of the human cerebral cortex (due to oxygenation and hemodynamic changes) can be explored by NIRS, human functional brain mapping research has gained a new dimension. fNIRS or optical topography, or near-infrared imaging or diffuse optical imaging is used mainly to detect simultaneous changes in optical properties of the human cortex from multiple measurement sites and displays the results in the form of a map or image over a specific area. In order to place current fNIRS research in its proper context, this paper presents a brief historical overview of the events that have shaped the present status of fNIRS. In particular, technological progresses of fNIRS are highlighted (i.e., from single-site to multi-site functional cortical measurements (images)), introduction of the commercial multi-channel systems, recent commercial wireless instrumentation and more advanced prototypes.

  5. Near-Infrared Emitting PbS Quantum Dots for in Vivo Fluorescence Imaging of the Thrombotic State in Septic Mouse Brain

    OpenAIRE

    2016-01-01

    Near-infrared (NIR) fluorescent imaging is a powerful tool for the non-invasive visualization of the inner structure of living organisms. Recently, NIR fluorescence imaging at 1000–1400 nm (second optical window) has been shown to offer better spatial resolution compared with conventional NIR fluorescence imaging at 700–900 nm (first optical window). Here we report lead sulfide (PbS) quantum dots (QDs) and their use for in vivo NIR fluorescence imaging of cerebral venous thrombosis in septic ...

  6. Transferring results from NIR-hyperspectral to NIR-multispectral imaging systems

    DEFF Research Database (Denmark)

    Calvini, Rosalba; Amigo Rubio, Jose Manuel; Ulrici, Alessandro

    2017-01-01

    commercially available filters matching the selected spectral regions, and used to calculate multivariate classification models with Partial Least Squares-Discriminant Analysis (PLS-DA) and sparse PLS-DA. Proper strategies for the definition of the training set and the selection of the most effective...

  7. High performance multi-channel MOSFET on InGaAs for RF amplifiers

    Science.gov (United States)

    Adhikari, Manoj Singh; Singh, Yashvir

    2017-02-01

    In this paper, we propose a multi-channel MOSFET (MC-MOSFET) on In0.53Ga0.47As for the first time by utilising trenches in the conventional planar MOSFET (CP-MOSFET) for RF amplifier applications. The proposed multi-channel MOSFET (MC-MOSFET) has two vertical-gates placed in trenches creating multiple channels in p-body for parallel conduction of drain current. High-k Al2O3 having thickness of 2 nm is used as gate dielectric in the proposed device. The TaN gate electrodes are placed in two different trenches in the p-type InGaAs layer where multiple n-channels are formed. Simultaneous conduction from multiple channels enhances the drain current (ID) and gives higher transconductance (gm) leading to improvement in overall frequency response. Two-dimensional (2D) numerical simulations of both MC-MOSFET and CP-MOSFET are performed by using ATLAS device simulator and their different performance parameters are compared. The proposed multi-channel structure provides 6.79 times higher ID, 5.57 times improvement in gm, 2.5 times increase in unity current gain (ft), 15.85% higher unilateral power gain (fmax) and suppress the short-channel effects (SCEs) as compared with the CP-MOSFET.

  8. Effect of arsenic cracking on In incorporation into MBE-grown InGaAs layer

    Energy Technology Data Exchange (ETDEWEB)

    Iha, Hiromu; Hirota, Yujiro; Yamauchi, Masatsugu; Yamamoto, Nao; Maruyama, Takahiro; Naritsuka, Shigeya [Graduate School of Science and Technology, Meijo University, 1-501 Shiogamaguchi, Tempaku-ku, Nagoya 468-8502 (Japan)

    2015-06-15

    The effect of arsenic cracking on In incorporation in MBE-grown InGaAs selective growth was systematically studied with changing the cracking cell temperature. Incorporation of In was greatly enhanced by the use of As{sub 2} molecular beam during the selective growth at 600 C. On the other hand, almost no In was incorporated into the grown layer by the use of a conventional As{sub 4} molecular beam. The relation between InAs mole fraction and the cracking cell temperature was found to monotonously increase with the cracking cell temperature. It is probably because the ratio of As{sub 2} molecules increases with the cracking cell temperature. Not only at 600 C but also at 580 C, a selective growth was also successfully performed using As{sub 2} molecular beam by the formation of the ''denuded zone'', with the InAs mole fraction of 10%. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  9. Stern-Gerlach effect and spin separation in InGaAs nanstructures

    Science.gov (United States)

    Kohda, Makoto

    2013-03-01

    The demonstration of quantized spin splitting by Stern and Gerlach in 1922 is one of the most important experiments in modern physics. We utilized an effective non-uniform magnetic field which originates from Rashba spin orbit interaction (SOI) and demonstrated an experimental manifestation of electronic Stern-Gerlach spin separation in InGaAs based quantum point contacts (QPCs). Lateral potential confinement in a trench-type QPC creates a spatial modulation of Rashba SOI inducing a spin dependent force Clear conductance plateaus are observed in steps of 2e2/ hwhen the strength of Rashba SOI becomes small. However, when the Rashba SOI is enhanced by applying the top gate, a half-integer plateau additionally appears at 0.5(2e2 / h) , indicating the spin polarized current. We found that the spin polarization of the conduction electrons in this plateau is as high as 70%. Our new approach for generating spin polarization in semiconductor nanostructures provides a way to seamlessly integrate electrical spin generation, manipulation, and detection in a single semiconductor device without the need for either external magnetic fields or magnetic materials. This work was supported in part by the PRESTO of the Japan Science and Technology Agency and by Grant-in-Aids from Japan Society for the Promotion of Science

  10. Temperature dependent photocurrent spectroscopy of a single InGaAs quantum dot

    Energy Technology Data Exchange (ETDEWEB)

    Huebner, Marc C.; Stufler, Stefan; Ester, Patrick; Michaelis de Vasconcellos, Steffen; Zrenner, Artur [Universitaet Paderborn, Fakultaet Naturwissenschaften, Department Physik, Warburger Strasse 100, 33098 Paderborn (Germany); Bichler, Max [Walter Schottky Institut, TU Muenchen, Am Coulombwall, 85748 Garching (Germany)

    2007-07-01

    Semiconductor quantum dots (QDs) exhibit discrete energy levels which can be described as two-level systems if resonant excitation within spectrally narrow regions is applied. Here we present cw excitation-experiments, carried out in a variable temperature setup up to 70 K allowing for investigations of coupling mechanisms to acoustic phonons. We have measured the photocurrent (PC) of a single InGaAs QD using a tuneable TiSa laser for resonant excitation. If a sufficiently high reverse bias voltage is applied, photogenerated carriers tunnel out of the QD. By tuning the excitation wavelength the spectral absorption of a single QD can be monitored via the PC. Within a limited range, a PC spectrum can be obtained by a sweep of the bias voltage at fixed laser wavelength. Tuning the applied voltage allows us to vary the linewidth, due to changing tunnelling probabilities. Increasing the temperature significantly shifts the transition energies of the QD to the red, extends the boundaries of the PC regime due to enhanced thermionic emission and also shows effect on the Rabi oscillations of the system.

  11. [The new method monitoring crop water content based on NIR-Red spectrum feature space].

    Science.gov (United States)

    Cheng, Xiao-juan; Xu, Xin-gang; Chen, Tian-en; Yang, Gui-jun; Li, Zhen-hai

    2014-06-01

    Moisture content is an important index of crop water stress condition, timely and effective monitoring of crop water content is of great significance for evaluating crop water deficit balance and guiding agriculture irrigation. The present paper was trying to build a new crop water index for winter wheat vegetation water content based on NIR-Red spectral space. Firstly, canopy spectrums of winter wheat with narrow-band were resampled according to relative spectral response function of HJ-CCD and ZY-3. Then, a new index (PWI) was set up to estimate vegetation water content of winter wheat by improveing PDI (perpendicular drought index) and PVI (perpendicular vegetation index) based on NIR-Red spectral feature space. The results showed that the relationship between PWI and VWC (vegetation water content) was stable based on simulation of wide-band multispectral data HJ-CCD and ZY-3 with R2 being 0.684 and 0.683, respectively. And then VWC was estimated by using PWI with the R2 and RMSE being 0.764 and 0.764, 3.837% and 3.840%, respectively. The results indicated that PWI has certain feasibility to estimate crop water content. At the same time, it provides a new method for monitoring crop water content using remote sensing data HJ-CCD and ZY-3.

  12. On the terminology of the spectral vegetation index (NIR – SWIR)/(NIR + SWIR)

    Science.gov (United States)

    Ji, Lel; Zhang, Li; Wylie, Bruce K.; Rover, Jennifer R.

    2011-01-01

    The spectral vegetation index (ρNIR – ρSWIR)/(ρNIR + ρSWIR), where ρNIR and ρSWIR are the near-infrared (NIR) and shortwave-infrared (SWIR) reflectances, respectively, has been widely used to indicate vegetation moisture condition. This index has multiple names in the literature, including infrared index (II), normalized difference infrared index (NDII), normalized difference water index (NDWI), normalized difference moisture index (NDMI), land surface water index (LSWI), and normalized burn ratio (NBR), etc. After reviewing each term’s definition, associated sensors, and channel specifications, we found that the index consists of three variants, differing only in the SWIR region (1.2–1.3 µm, 1.55–1.75 µm, or 2.05–2.45 µm). Thus, three terms are sufficient to represent these three SWIR variants; other names are redundant and therefore unnecessary. Considering the spectral representativeness, the term’s popularity, and the “rule of priority” in scientific nomenclature, NDWI, NDII, and NBR, each corresponding to the three SWIR regions, are more preferable terms.

  13. What good is SWIR? Passive day comparison of VIS, NIR, and SWIR

    Science.gov (United States)

    Driggers, Ronald G.; Hodgkin, Van; Vollmerhausen, Richard

    2013-06-01

    This paper is the first of three papers associated with the military benefits of SWIR imaging. This paper describes the benefits associated with passive daytime operations with comparisons of SWIR, NIR, and VIS bands and sensors. This paper includes quantitative findings from previously published papers, analysis of open source data, summaries of various expert analyses, and calculations of notional system performance. We did not accept anecdotal findings as acceptable benefits. Topics include haze and fog penetration, atmospheric transmission, cloud and smoke penetration, target and background contrasts, spectral discrimination, turbulence degradation, and long range target identification. The second and third papers will address passive night imaging and active night imaging.

  14. Diversity of nitrite reductase genes (nirS) in the denitrifying water column of the coastal Arabian Sea

    Digital Repository Service at National Institute of Oceanography (India)

    Jayakumar, D.A.; Francis, C.A.; Naqvi, S.W.A.; Ward, B.B.

    and 1 sequence from Sample G840. Cluster VIII contained the majority (23 of 26) of the sequences from Sample V400. Many of the se- quences in Cluster VIII were virtually identical to the nirS sequence of the cultivated denitrifier Pseudo- monas... environmental clone, exhibiting close identity to a cul- tured denitrifier species, was also observed in a recent study of the River Colne estuary sediments, in which virtually identical nirS sequences were obtained from a Flavobacterium isolate and from 2 RT...

  15. Photonic MEMS for NIR in-situ

    Energy Technology Data Exchange (ETDEWEB)

    Bond, T C; Cole, G D; Goddard, L L; Behymer, E

    2007-07-03

    We report on a novel sensing technique combining photonics and microelectromechanical systems (MEMS) for the detection and monitoring of gas emissions for critical environmental, medical, and industrial applications. We discuss how MEMS-tunable vertical-cavity surface-emitting lasers (VCSELs) can be exploited for in-situ detection and NIR spectroscopy of several gases, such as O{sub 2}, N{sub 2}O, CO{sub x}, CH{sub 4}, HF, HCl, etc., with estimated sensitivities between 0.1 and 20 ppm on footprints {approx}10{sup -3} mm{sup 3}. The VCSELs can be electrostatically tuned with a continuous wavelength shift up to 20 nm, allowing for unambiguous NIR signature determination. Selective concentration analysis in heterogeneous gas compositions is enabled, thus paving the way to an integrated optical platform for multiplexed gas identification by bandgap and device engineering. We will discuss here, in particular, our efforts on the development of a 760 nm AlGaAs based tunable VCSEL for O{sub 2} detection.

  16. Analysis of self-organized In(Ga)As quantum structures with the scanning transmission electron microscope; Analyse selbstorganisierter In(Ga)As-Quantenstrukturen mit dem Raster-Transmissionselektronenmikroskop

    Energy Technology Data Exchange (ETDEWEB)

    Sauerwald, Andres

    2008-05-27

    Aim of this thesis was to apply the analytical methods of the scanning transmission electron microscopy to the study of self-organized In(Ga)As quantum structures. With the imaging methods Z contrast and bright field (position resolutions in the subnanometer range) and especially with the possibilities of the quantitative chemical EELS analysis of the scanning transmission electron microscope (STEM) fundamental questions concerning morphology and chemical properties of self-organized quantum structures should be answered. By the high position resolution of the STEM among others essentail morphological and structural parameters in the growth behaviour of 'dot in a well' (DWell) structures and of vertically correlated quantum dots (QDs) could be analyzed. For the optimization of DWell structures samples were studied, the nominal InAs-QD growth position was directedly varied within the embedding InGaAs quantum wells. The STEM offers in connection with the EELS method a large potential for the chemical analysis of quantum structures. Studied was a sample series of self-organized InGaAs/GaAs structures on GaAs substrate, the stress of which was changed by varying the Ga content of the INGaAs material between 2.4 % and 4.3 %. [German] Ziel dieser Arbeit war es, die analytischen Methoden der Raster-Transmissionselektronenmikroskopie zur Untersuchung selbstorganisierter In(Ga)As-Quantenstrukturen anzuwenden. Mit den abbildenden Methoden Z-Kontrast und Hellfeld (Ortsaufloesungen im Subnanometerbereich) und insbesondere mit den Moeglichkeiten der quantitativen chemischen EELS-Analyse des Raster-Transmissionselektronenmikroskops (RTEMs) sollten grundsaetzliche Fragestellungen hinsichtlich der Morphologie und der chemischen Eigenschaften selbstorganisierter Quantenstrukturen beantwortet werden. Durch die hohe Ortsaufloesung des RTEMs konnten u.a. essentielle morphologische und strukturelle Parameter im Wachstumsverhalten von 'Dot in a Well

  17. Effect of Resting-State fNIRS Scanning Duration on Functional Brain Connectivity and Graph Theory Metrics of Brain Network

    Directory of Open Access Journals (Sweden)

    Shujie Geng

    2017-07-01

    Full Text Available As an emerging brain imaging technique, functional near infrared spectroscopy (fNIRS has attracted widespread attention for advancing resting-state functional connectivity (FC and graph theoretical analyses of brain networks. However, it remains largely unknown how the duration of the fNIRS signal scanning is related to stable and reproducible functional brain network features. To answer this question, we collected resting-state fNIRS signals (10-min duration, two runs from 18 participants and then truncated the hemodynamic time series into 30-s time bins that ranged from 1 to 10 min. Measures of nodal efficiency, nodal betweenness, network local efficiency, global efficiency, and clustering coefficient were computed for each subject at each fNIRS signal acquisition duration. Analyses of the stability and between-run reproducibility were performed to identify optimal time length for each measure. We found that the FC, nodal efficiency and nodal betweenness stabilized and were reproducible after 1 min of fNIRS signal acquisition, whereas network clustering coefficient, local and global efficiencies stabilized after 1 min and were reproducible after 5 min of fNIRS signal acquisition for only local and global efficiencies. These quantitative results provide direct evidence regarding the choice of the resting-state fNIRS scanning duration for functional brain connectivity and topological metric stability of brain network connectivity.

  18. Online NIR diagnostic of laser welding processes and its potential for quality assuring sensor systems

    Science.gov (United States)

    Dorsch, Friedhelm; Braun, Holger; Keβler, Steffen; Pfitzner, Dieter; Rominger, Volker

    2014-02-01

    We have integrated an imaging thermographic sensor into commercial welding optics for observation of the weld zone. Key element of the sensor is an InGaAs-camera that detects the thermal radiation of the welding process in the wavelength range of 1,200 to 1,700 nm. This is well suited to record images of the keyhole, the melt pool and the thermal trace. The sensor was integrated to the welding heads for on-axis observation to minimize the interfering contour to ensure easy adaption to industrial processes. The welding heads used were established industrial-grade TRUMPF optics: a BEO fixed optics with 280 mm focal length, or a TRUMPF PFO-3D scanner optics with 450 mm focal length. We used a TRUMPF TruDisk 16002 16kW-thin disk laser that transmits its power through a 200 μm core diameter light cable. The images were recorded and features of the various process zones were evaluated by image processing. It turns out that almost all weld faults can be clearly detected in the NIR images. Quantitative features like the dimension of the melt pool and the thermal trace can be derived from the captured images. They are correlated to process input parameters as well as to process results. In contrast to observation in the visible spectrum the NIR camera records the melt pool without auxiliary illumination. As an unrivaled attribute of the NIR sensor it supports an online heat flow thermography of the seam and allows identifying missing fusion ("false friends") of lap joints virtually during the welding process. Automated weld fault detection and documentation is possible by online image processing which sets the basis for comprehensive data documentation for quality assurance and traceability.

  19. The NIR arm of SHARK: System for coronagraphy with High-order Adaptive optics from R to K bands

    Science.gov (United States)

    Farinato, Jacopo; Baffa, Carlo; Baruffolo, Andrea; Bergomi, Maria; Carbonaro, Luca; Carlotti, Alexis; Centrone, Mauro; Codona, Johanan; Dima, Marco; Esposito, Simone; Fantinel, Daniela; Farisato, Giancarlo; Gaessler, Wolfgang; Giallongo, Emanuele; Greggio, Davide; Hinz, Philip; Lisi, Franco; Magrin, Demetrio; Marafatto, Luca; Pedichini, Fernando; Pinna, Enrico; Puglisi, Alfio; Ragazzoni, Roberto; Salasnich, Bernardo; Stangalini, Marco; Verinaud, Christophe; Viotto, Valentina

    2015-07-01

    SHARK is a proposal aimed at investigating the technical feasibility and the scientific capabilities of high-contrast cameras to be implemented at the Large Binocular Telescope (LBT). SHARK foresees two separated channels: near-infrared (NIR) channel and visible, both providing imaging and coronagraphic modes. We describe here the SHARK instrument concept, with particular emphasis on the NIR channel at the level of a conceptual study, performed in the framework of the call for proposals for new LBT instruments. The search for giant extra-Solar planets is the main science case, as we will outline in the paper.

  20. A New NIR Flareof the QSO PMNJ2301-0157

    Science.gov (United States)

    Carrasco, L.; Miramon, J.; Recillas, E.; Porras, A.; Chavushyan, V.; Mayya, D. Y.

    2016-12-01

    We report on the new NIR flare of the high redshift QSO PMNJ2301-0157 (z=0.778), cross identified with the source BZQJ 2301-1058. On November 13th,2016 (MJD 2457705.722), we found the source with the following flux in the NIR band: H = 14.287 +/- 0.03.

  1. NIR Flare of the AGN Candidate PMNJ0107+0333

    Science.gov (United States)

    Carrasco, L.; Miramon, J.; Recillas, E.; Porras, A.; Chavushyan, V.; Mayya, D. Y.

    2016-12-01

    We report on the new NIR flare of the AGN candidate PMNJ0107+0333, cross identified with the X-ray source 1RXS J010729.5+033341. On November 13th,2016 (MJD 2457705.699), we found the source with the following flux in the NIR band: H = 14.657 +/- 0.05.

  2. Cotton micronaire measurements by small portable near infrared (nir) analyzers

    Science.gov (United States)

    A key quality and processing parameter for cotton fiber is micronaire, which is a function of the fiber’s maturity and fineness. Near Infrared (NIR) spectroscopy has previously shown the ability to measure micronaire, primarily in the laboratory and using large, research-grade laboratory NIR instru...

  3. Generation of continuous wave terahertz frequency radiation from metal-organic chemical vapour deposition grown Fe-doped InGaAs and InGaAsP

    Energy Technology Data Exchange (ETDEWEB)

    Mohandas, Reshma A.; Freeman, Joshua R., E-mail: j.r.freeman@leeds.ac.uk; Rosamond, Mark C.; Chowdhury, Siddhant; Cunningham, John E.; Davies, A. Giles; Linfield, Edmund H.; Dean, Paul [School of Electronic and Electrical Engineering, University of Leeds, Leeds LS2 9JT (United Kingdom); Hatem, Osama [School of Electronic and Electrical Engineering, University of Leeds, Leeds LS2 9JT (United Kingdom); Department of Engineering Physics, Faculty of Engineering, Tanta University, PO Box 31521, Tanta (Egypt); Ponnampalam, Lalitha; Fice, Martyn; Seeds, Alwyn J. [Department of Electronic and Electrical Engineering, University College London, London WC1E 6BT (United Kingdom); Cannard, Paul J.; Robertson, Michael J.; Moodie, David G. [CIP Technologies, Adastral Park, Martlesham Heath, Ipswich, Suffolk IP5 3RE (United Kingdom)

    2016-04-21

    We demonstrate the generation of continuous wave terahertz (THz) frequency radiation from photomixers fabricated on both Fe-doped InGaAs and Fe-doped InGaAsP, grown by metal-organic chemical vapor deposition. The photomixers were excited using a pair of distributed Bragg reflector lasers with emission around 1550 nm, and THz radiation was emitted over a bandwidth of greater than 2.4 THz. Two InGaAs and four InGaAsP wafers with different Fe doping concentrations were investigated, with the InGaAs material found to outperform the InGaAsP in terms of emitted THz power. The dependencies of the emitted power on the photomixer applied bias, incident laser power, and material doping level were also studied.

  4. Precise spatial co-registration in simultaneous fNIRS and fMRI measurements using markers coaxially fixable to the optodes

    Science.gov (United States)

    Yamada, Toru; Matsuda, Keiji; Iwano, Takayuki; Umeyama, Shinji

    2014-03-01

    Similar to blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI), functional nearinfrared spectroscopy (fNIRS) observes regional hemodynamic responses associated with neuronal activation. However, the conventional criteria for detecting true positive fNIRS and fMRI signals appear to be based on different understandings of cerebral hemodynamics. Considerable numbers of fNIRS studies have ascribed the increase in oxygenated hemoglobin to a typical sign of functional activation, whereas the corresponding BOLD signal in fMRI directly correlates with a decrease in deoxygenated hemoglobin. This inconsistency requires solution through the simultaneous measurements of fNIRS and fMRI. In practice, however, there remain several technical problems associated with conducting simultaneous measurements with high reproducibility. One issue is the precise spatial registration of NIRS optodes in MR images. We prepared marker containers of an annular shape that can be coaxially fixed to the optode. Liquid paraffin with α-tocopheryl acetate, which exhibits a bright contrast in T1-weighted MR images of human heads, was solidified in each container by adding higher fatty acid. A subject wearing the marker-fixed optodes at parietal area participated in preliminary fNIRS and fMRI experiments; the subject was instructed to execute single-sided hand finger tapping. The positions showed that deoxygenated hemoglobin decreases in fNIRS coincided with the BOLD-positive region in fMRI. The prepared marker is chemically stable and repetitively usable. We believe that this simple method contributes precision to the co-registration of fNIRS and fMRI.

  5. Structure and Photoluminescence of InGaAs Quantum Dots Formed on an InA1As Wetting Layer

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yuan-Chang; YE Xiao-Ling; XU Bo; DING Ding; WANG Ji-Zheng; LI Yue-Fa; LIU Feng-Qi; WANG Zhan-Guo; HUANG Chang-Jun

    2001-01-01

    We have developed a nev self-assembled quantum dot system where InGaAs dots are formed on an InAlAs wetting layer and embedded in the GaAs matrix. The structure is realized by special sample designation and demonstrated by low-temperature photoluminescence measurements. In contrast to the traditional InAs/GaAs quantum dots dominated by the ensemble effect, the temperature dependence of the photoluminescence of such a quantum dot structure behaves as decoupled quantum dots. This can be attributed to the enhanced potential confinement for the dots provided by a higher-energy barrier in the wetting layer

  6. Saturation effects in heterodyne detection with Geiger-mode InGaAs avalanche photodiode detector arrays.

    Science.gov (United States)

    Luu, Jane X; Jiang, Leaf A

    2006-06-01

    We report, to the best of our knowledge, the first demonstration of heterodyne detection of a glint target using an InGaAs avalanche photodiode detector (APD) array in the Geiger mode. Due to the finite number of pixels, all such photon-counting arrays necessarily suffer from saturation effects. At large photon fluxes, saturation of the APD degrades the Doppler frequency resolution and the signal-to-noise ratio (SNR). We derive analytical expressions for the Doppler resolution and SNR, taking saturation effects into account. The optimal local oscillator power can be obtained numerically from the SNR expression.

  7. Detection of terahertz radiation by tightly concatenated InGaAs field-effect transistors integrated on a single chip

    Energy Technology Data Exchange (ETDEWEB)

    Popov, V. V., E-mail: popov-slava@yahoo.co.uk [Kotelnikov Institute of Radio Engineering and Electronics (Saratov Branch), Russian Academy of Sciences, Saratov 410019 (Russian Federation); Yermolaev, D. M.; Shapoval, S. Yu. [Institute of Microelectronic Technology and High-Purity Materials, Russian Academy of Sciences, Chernogolovka, Moscow Region 142432 (Russian Federation); Maremyanin, K. V.; Gavrilenko, V. I. [Institute for Physics of Microstructures, Russian Academy of Sciences, Nizhny Novgorod 603950 (Russian Federation); Lobachevsky State University of Nizhni Novgorod, Nizhni Novgorod 603950 (Russian Federation); Zemlyakov, V. E.; Bespalov, V. A.; Yegorkin, V. I. [National Research University of Electronic Technology, Zelenograd, Moscow 124498 (Russian Federation); Maleev, N. A.; Ustinov, V. M. [Ioffe Physical Technical Institute, Russian Academy of Sciences, St. Petersburg 194021 (Russian Federation)

    2014-04-21

    A tightly concatenated chain of InGaAs field-effect transistors with an asymmetric T-gate in each transistor demonstrates strong terahertz photovoltaic response without using supplementary antenna elements. We obtain the responsivity above 1000 V/W and up to 2000 V/W for unbiased and drain-biased transistors in the chain, respectively, with the noise equivalent power below 10{sup −11} W/Hz{sup 0.5} in the unbiased mode of the detector operation.

  8. Optical emission of strained direct-band-gap Ge quantum well embedded inside InGaAs alloy layers

    OpenAIRE

    Pavarelli, Nicola; Ochalski, Tomasz J.; Murphy-Armando, Felipe; Huo, Y; Schmidt, Michael; Huyet, Guillaume; Harris, J. S.

    2013-01-01

    We studied the optical properties of a strain-induced direct-band-gap Ge quantum well embedded in InGaAs. We showed that the band offsets depend on the electronegativity of the layer in contact with Ge, leading to different types of optical transitions in the heterostructure. When group-V atoms compose the interfaces, only electrons are confined in Ge, whereas both carriers are confined when the interface consists of group-III atoms. The different carrier confinement results in different emis...

  9. Prediction of pork quality with near infrared spectroscopy (NIRS): 1. Feasibility and robustness of NIRS measurements at laboratory scale

    NARCIS (Netherlands)

    Kapper, C.; Klont, R.E.; Verdonk, J.M.A.J.; Urlings, H.A.P.

    2012-01-01

    The objective was to study prediction of pork quality by near infrared spectroscopy (NIRS) technology in the laboratory. A total of 131 commercial pork loin samples were measured with NIRS. Predictive equations were developed for drip loss %, colour L*, a*, b* and pH ultimate (pHu). Equations with

  10. Aromatic Fused [30] Heteroannulenes with NIR Absorption and NIR Emission: Synthesis, Characterization, and Excited-State Dynamics.

    Science.gov (United States)

    Mallick, Abhijit; Oh, Juwon; Kim, Dongho; Rath, Harapriya

    2016-06-06

    Two hitherto unknown planar aromatic [30] fused heterocyclic macrocycles (1.1.0.1.1.0), with NIR absorption in free-base form and protonation-induced enhanced NIR emission, have been synthesized from easy to make precursors. The induced correspondence of fusion on the macrocyclic structure, electronic absorption, and emission spectra have been highlighted.

  11. Anterior temporal artery tap to identify systemic interference using short-separation NIRS measurements

    DEFF Research Database (Denmark)

    Sood, Mehak; Jindal, Utkarsh; Chowdhury, Shubhajit Roy

    2015-01-01

    Transcranial direct current stimulation (tDCS) has been shown to modulate neural activity. Neural activity has been shown to be closely related, spatially and temporally, to cerebral blood flow (CBF) that supplies glucose via neurovascular coupling. Therefore, noninvasive and continuous monitoring...... identify systemic interference using this short-separation NIRS. Moreover, NIRS-EEG joint-imaging during anodal tDCS was used to measure changes in mean cerebral haemoglobin oxygen saturation (rSO2) along with changes in the log-transformed mean-power of EEG within 0.5 Hz-11.25 Hz. We found that percent...... change in the mean rSO2 better correlated with the corresponding percent change in log-transformed mean-power of EEG within 0.5 Hz-11.25 Hz frequency band after removing the systemic contamination using the temporal artery tap method. Based on our findings, we propose that anterior temporal artery tap...

  12. Magnetic Field Effects on Triplet-Triplet Annihilation in Solutions: Modulation of Visible/NIR Luminescence.

    Science.gov (United States)

    Mani, Tomoyasu; Vinogradov, Sergei A

    2013-08-01

    Photon upconversion based on sensitized triplet-triplet annihilation (TTA) presents interest for such areas as photovoltaics and imaging. Usually energy upconversion is observed as p-type delayed fluorescence from molecules whose triplet states are populated via energy transfer from a suitable triplet donor, followed by TTA. Magnetic field effects (MFE) on delayed fluorescence in molecular crystals are well known; however, there exist only a few examples of MFE on TTA in solutions, and all of them are limited to UV-emitting materials. Here we present MFE on TTA-mediated visible and near infrared (NIR) emission, sensitized by far-red absorbing metalloporphyrins in solutions at room temperature. In addition to visible delayed fluorescence from annihilator, we also observed NIR emission from the sensitizer, occurring as a result of triplet-triplet energy transfer back from annihilator, termed "delayed phosphorescence". This emission also exhibits MFE, but opposite in sign to the annihilator fluorescence.

  13. High kappa Dielectrics on InGaAs and GaN - Growth, Interfacial Structural Studies, and Surface Fermi Level Unpinning

    Science.gov (United States)

    2011-04-20

    interface have attributed to the high device performance. In addition, compared to the state-of-the-art GaN HEMT devices, the HfO2/ GaN MOSFET...Final Report for FA2386-10-1-4058 AOARD Grant 104058 Research Title: High  dielectrics on InGaAs and GaN - Growth, interfacial structural studies...on the science and technology of III-V InGaAs and GaN metal-oxide-semiconductor (MOS) systems using high dielectrics. The new technology of high

  14. Spin Polarization of Carriers in InGaAs Self-Assembled Quantum Rings Inserted in GaAs-AlGaAs Resonant Tunneling Devices

    Science.gov (United States)

    Orsi Gordo, V.; Gobato, Y. Galvão; Galeti, H. V. A.; Brasil, M. J. S. P.; Taylor, D.; Henini, M.

    2017-03-01

    In this work, we have investigated transport and polarization resolved photoluminescence (PL) of n-type GaAs-AlGaAs resonant tunneling diodes (RTDs) containing a layer of InGaAs self-assembled quantum rings (QRs) in the quantum well (QW). All measurements were performed under applied voltage, magnetic fields up to 15 T and using linearly polarized laser excitation. It was observed that the QRs' PL intensity and the circular polarization degree (CPD) oscillate periodically with applied voltage under high magnetic fields at 2 K. Our results demonstrate an effective voltage control of the optical and spin properties of InGaAs QRs inserted into RTDs.

  15. Absolute Radiation Thermometry in the NIR

    Science.gov (United States)

    Bünger, L.; Taubert, R. D.; Gutschwager, B.; Anhalt, K.; Briaudeau, S.; Sadli, M.

    2017-04-01

    A near infrared (NIR) radiation thermometer (RT) for temperature measurements in the range from 773 K up to 1235 K was characterized and calibrated in terms of the "Mise en Pratique for the definition of the Kelvin" (MeP-K) by measuring its absolute spectral radiance responsivity. Using Planck's law of thermal radiation allows the direct measurement of the thermodynamic temperature independently of any ITS-90 fixed-point. To determine the absolute spectral radiance responsivity of the radiation thermometer in the NIR spectral region, an existing PTB monochromator-based calibration setup was upgraded with a supercontinuum laser system (0.45 μm to 2.4 μm) resulting in a significantly improved signal-to-noise ratio. The RT was characterized with respect to its nonlinearity, size-of-source effect, distance effect, and the consistency of its individual temperature measuring ranges. To further improve the calibration setup, a new tool for the aperture alignment and distance measurement was developed. Furthermore, the diffraction correction as well as the impedance correction of the current-to-voltage converter is considered. The calibration scheme and the corresponding uncertainty budget of the absolute spectral responsivity are presented. A relative standard uncertainty of 0.1 % (k=1) for the absolute spectral radiance responsivity was achieved. The absolute radiometric calibration was validated at four temperature values with respect to the ITS-90 via a variable temperature heatpipe blackbody (773 K ...1235 K) and at a gold fixed-point blackbody radiator (1337.33 K).

  16. NIRS-based noninvasive cerebrovascular regulation assessment

    Science.gov (United States)

    Miller, S.; Richmond, I.; Borgos, J.; Mitra, K.

    2016-03-01

    Alterations to cerebral blood flow (CBF) have been implicated in diverse neurological conditions, including mild traumatic brain injury, microgravity induced intracranial pressure (ICP) increases, mild cognitive impairment, and Alzheimer's disease. Near infrared spectroscopy (NIRS)-measured regional cerebral tissue oxygen saturation (rSO2) provides an estimate of oxygenation of the interrogated cerebral volume that is useful in identifying trends and changes in oxygen supply to cerebral tissue and has been used to monitor cerebrovascular function during surgery and ventilation. In this study, CO2-inhalation-based hypercapnic breathing challenges were used as a tool to simulate CBF dysregulation, and NIRS was used to monitor the CBF autoregulatory response. A breathing circuit for the selective administration of CO2-compressed air mixtures was designed and used to assess CBF regulatory responses to hypercapnia in 26 healthy young adults using non-invasive methods and real-time sensors. After a 5 or 10 minute baseline period, 1 to 3 hypercapnic challenges of 5 or 10 minutes duration were delivered to each subject while rSO2, partial pressure of end tidal CO2 (PETCO2), and vital signs were continuously monitored. Change in rSO2 measurements from pre- to intrachallenge (ΔrSO2) detected periods of hypercapnic challenges. Subjects were grouped into three exercise factor levels (hr/wk), 1: 0, 2:>0 and 10. Exercise factor level 3 subjects showed significantly greater ΔrSO2 responses to CO2 challenges than level 2 and 1 subjects. No significant difference in ΔPETCO2 existed between these factor levels. Establishing baseline values of rSO2 in clinical practice may be useful in early detection of CBF changes.

  17. Star formation, structure, and formation mechanism of cometary globules: NIR observations of CG 1 and CG 2

    CERN Document Server

    Mäkelä, M M

    2012-01-01

    Cometary globule (CG) 1 and CG 2 are "classic" CGs in the Gum Nebula. They have compact heads and long dusty tails that point away from the centre of the Gum Nebula. We study the structure of CG 1 and CG 2 and the star formation in them to find clues to the CG formation mechanism. The two possible mechanisms, radiation-driven implosion (RDI) and a supernova (SN) blast wave, produce a characteristic mass distribution where the major part of the mass is situated in either the head (RDI) or the tail (SN). CG 1 and CG 2 were imaged in the near infrared (NIR) JsHKs bands. NIR photometry was used to locate NIR excess objects and to create extinction maps of the CGs. The A_V maps allow us to analyse the large-scale structure of CG 1 and CG 2. Archival images from the WISE and Spitzer satellites and HIRES-processed IRAS images were used to study the small-scale structure. In addition to the previously known CG 1 IRS 1 we discovered three new NIR-excess objects, two in CG 1 and one in CG 2. CG 2 IRS 1 is the first det...

  18. Diseno y construccion de un espectrometro NIR; Design and construction of a NIR spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Barcala Riveira, J. M.; Fernandez Marron, J. L.; Alberdi Primicia, J.; Molero Menendez, F.; Navarrete Marin, J. J.; Oller Gonzalez, J. C.

    2003-07-01

    This document describes the design and construction of a NIR spectrometer based on an acoustic-optic tunable filter. The spectrometer will be used for automatic identification of plastics in domestic waste. The system works between 1200 and 1800 nm. Instrument is controlled by a personal computer. Computer receives and analyses data. A software package has been developed to do these tasks. (Author) 27 refs.

  19. Photostable water-dispersible NIR-emitting CdTe/CdS/ZnS core-shell-shell quantum dots for high-resolution tumor targeting.

    Science.gov (United States)

    Wang, Jie; Lu, Yimei; Peng, Fei; Zhong, Yiling; Zhou, Yanfeng; Jiang, Xiangxu; Su, Yuanyuan; He, Yao

    2013-12-01

    Near-infrared (NIR, 700-900 nm) fluorescent quantum dots are highly promising as NIR bioprobes for high-resolution and high-sensitivity bioimaging applications. In this article, we present a class of NIR-emitting CdTe/CdS/ZnS core-shell-shell quantum dots (QDs), which are directly prepared in aqueous phase via a facile microwave synthesis. Significantly, the prepared NIR-emitting QDs possess excellent aqueous dispersibility, strong photoluminescence, favorable biocompatibility, robust storage-, chemical-, and photo-stability, and finely tunable emission in the NIR range (700-800 nm). The QDs are readily functionalized with antibodies for use in immunofluorescent bioimaging, yielding highly spectrally and spatially resolved emission for in vitro and in vivo imaging. In comparison to the large size of 15-30 nm of the conventional NIR QDs, the extremely small size (≈ 4.2 nm or 7.5 nm measured by TEM or DLS, respectively) of our QDs offers great opportunities for high-efficiency and high-sensitivity targeted imaging in cells and animals.

  20. Near-infrared autofluorescence imaging for colonic cancer detection

    Science.gov (United States)

    Shao, Xiaozhuo; Zheng, Wei; Huang, Zhiwei

    2009-11-01

    We explore an NIR autofluorescence imaging technique for cancer diagnosis and detection. A set of tissue images including NIR white light images, autofluorescence (AF) images and fluorescence polarized images (FPI) (parallel-, and perpendicular- polarization) were acquired in tandem on human colonic tissues. The results show that NIR fluorescence intensity of normal tissue is significantly higher than that of cancer tissue. The perpendicular-polarization image yields the highest diagnostic accuracy 93% compared to other imaging modes. This work demonstrates that Fluorescence polarization imaging (FPI) technique has great potential for cancer diagnosis and detection in the colon.

  1. Border trap reduction in Al{sub 2}O{sub 3}/InGaAs gate stacks

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Kechao; McIntyre, Paul C. [Department of Materials Science and Engineering, Stanford University, Stanford, California 94305 (United States); Winter, Roy; Eizenberg, Moshe [Department of Materials Science and Engineering, Technion—Israel Institute of Technology, Haifa 32000 (Israel); Zhang, Liangliang [Department of Electrical Engineering, Stanford University, Stanford, California 9430 (United States); Droopad, Ravi [Department of Physics, Texas State University, San Marcos, Texas 78666 (United States)

    2015-11-16

    The effect of Al{sub 2}O{sub 3} atomic layer deposition (ALD) temperature on the border trap density (N{sub bt}) of Al{sub 2}O{sub 3}/InGaAs gate stacks is investigated quantitatively, and we demonstrate that lowering the trimethylaluminum (TMA)/water vapor ALD temperature from 270 °C to 120 °C significantly reduces N{sub bt}. The reduction of N{sub bt} coincides with increased hydrogen incorporation in low temperature ALD-grown Al{sub 2}O{sub 3} films during post-gate metal forming gas annealing. It is also found that large-dose (∼6000 L) exposure of the In{sub 0.53}Ga{sub 0.47}As (100) surface to TMA immediately after thermal desorption of a protective As{sub 2} capping layer is an important step to guarantee the uniformity and reproducibility of high quality Al{sub 2}O{sub 3}/InGaAs samples made at low ALD temperatures.

  2. NIR fluorescent dyes: versatile vehicles for marker and probe applications

    Science.gov (United States)

    Patonay, Gabor; Chapman, Gala; Beckford, Garfield; Henary, Maged

    2013-02-01

    The use of the NIR spectral region (650-900 nm) is advantageous due to the inherently lower background interference and the high molar absorptivities of NIR chromophores. Near-Infrared (NIR) dyes are increasingly used in the biological and medical field. The binding characteristics of NIR dyes to biomolecules are possibly controlled by several factors, including hydrophobicity, size and charge just to mention a few parameters. Binding characteristics of symmetric carbocyanines and found that the hydrophobic nature of the NIR dye is only partially responsible for the binding strength. Upon binding to biomolecules significant fluorescence enhancement can be observed for symmetrical carbocyanines. This fluorescence amplification facilitates the detection of the NIR dye and enhances its utility as NIR reporter. This manuscript discusses some probe and marker applications of such NIR fluorescent dyes. One application discussed here is the use of NIR dyes as markers. For labeling applications the fluorescence intensity of the NIR fluorescent label can significantly be increased by enclosing several dye molecules in nanoparticles. To decrease self quenching dyes that have relatively large Stokes' shift needs to be used. This is achieved by substituting meso position halogens with amino moiety. This substitution can also serve as a linker to covalently attach the dye molecule to the nanoparticle backbone. We report here on the preparation of NIR fluorescent silica nanoparticles. Silica nanoparticles that are modified with aminoreactive moieties can be used as bright fluorescent labels in bioanalytical applications. A new bioanalytical technique to detect and monitor the catalytic activity of the sulfur assimilating enzyme using NIR dyes is reported as well. In this spectroscopic bioanalytical assay a family of Fischer based n-butyl sulfonate substituted dyes that exhibit distinct variation in absorbance and fluorescence properties and strong binding to serum albumin as its

  3. Investigations on NIR-SERS Spectra of Serum for Liver Cancer Based on NIR-SERS Substrate%基于新型NIR-SERS基底的肝癌血清NIR-SERS光谱研究

    Institute of Scientific and Technical Information of China (English)

    刘仁明; 刘瑞明; 武延春; 柳振全; 张德清; 自兴发; 司民真

    2011-01-01

    Investigations on near infrared surface-enhanced Raman scattering (NIR-SERS) spectra of the serum for patients with liver cancer and healthy persons based on Ag nanofilms prepared by using electrostatic self-assembly are reported. Analysis indicates NIR-SERS spectra of the sera between healthy persons and liver cancer patients are different. Firstly, Raman bands at 630, 720, 812 and 1578 cm-1 become weaker (even disappear) in NIR-SERS spectra of the sera for cancer liver patients but stronger in NIR-SERS spectra of the sera for healthy persons.Secondly, Raman bands at 1130 cm-1 and 1204 cm-1 in NIR-SERS spectra of the sera for healthy persons have blue shifts to 1135 cm-1 and 1269 cm 1 in NIR-SERS spectra of sera for cancer liver patients, respectively. Meanwhile, a new Raman band at 558 cm-1 appears in NIR-SERS spectra of liver cancer patients. Additionally, striking spectral differences are abvious in NIR-SERS spectra in the intensity ratios at 630/300, 1130/300, and 1578/300 cm-1.These three peak-intensity ratios of liver cancer patients with values of 0. 848±0. 042, 1. 094~ 0. 118, 0. 914 ± 0. 070, respectively, are more notable (mean ~ S. D., n = 15, P < 0.01 ) compared with those of healthy persons (1.985t0. 487, 1.568±0.286, 1. 189±0. 108, respectively). The results show that the intensity relative peak-ratios at 630/300, 1130/300, and 1578/300 cm-1 can be used to discriminate liver cancer patients from healthy persons, which indicate these three intensity ratios can be served as N1R-SERS spectral criteria for the diagnosis of cancer liver.%基于一种新型、高效、生物兼容性近红外表面增强拉曼散射(NIR-SERS)基底,采用便携式近红外拉曼光谱仪分别对健康人和肝癌病患者的血清进行了NIR-SERS光谱研究.实验发现,健康人与肝癌患者的血清NIR-SERS光谱存在显著差异:1)健康人血清NIR-SERS光谱中位于630、720、812和1578 cm-1附近的谱峰在肝癌患者血清NIR-SERS光

  4. Widely tunable alloy composition and crystal structure in catalyst-free InGaAs nanowire arrays grown by selective area molecular beam epitaxy

    Energy Technology Data Exchange (ETDEWEB)

    Treu, J., E-mail: Julian.Treu@wsi.tum.de, E-mail: Gregor.Koblmueller@wsi.tum.de; Speckbacher, M.; Saller, K.; Morkötter, S.; Xu, X.; Riedl, H.; Abstreiter, G.; Finley, J. J.; Koblmüller, G., E-mail: Julian.Treu@wsi.tum.de, E-mail: Gregor.Koblmueller@wsi.tum.de [Walter Schottky Institut, Physik Department, Center of Nanotechnology and Nanomaterials, Technische Universität München, Am Coulombwall 4, Garching 85748 (Germany); Döblinger, M. [Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, Munich 81377 (Germany)

    2016-02-01

    We delineate the optimized growth parameter space for high-uniformity catalyst-free InGaAs nanowire (NW) arrays on Si over nearly the entire alloy compositional range using selective area molecular beam epitaxy. Under the required high group-V fluxes and V/III ratios, the respective growth windows shift to higher growth temperatures as the Ga-content x(Ga) is tuned from In-rich to Ga-rich InGaAs NWs. Using correlated x-ray diffraction, transmission electron microscopy, and micro-photoluminescence spectroscopy, we identify structural defects to govern luminescence linewidths in In-rich (x(Ga) < 0.4) and Ga-rich (x(Ga) > 0.6) NWs, whereas limitations at intermediate Ga-content (0.4 < x(Ga) < 0.6) are mainly due to compositional inhomogeneities. Most remarkably, the catalyst-free InGaAs NWs exhibit a characteristic transition in crystal structure from wurtzite to zincblende (ZB) dominated phase near x(Ga) ∼ 0.4 that is further reflected in a cross-over from blue-shifted to red-shifted photoluminescence emission relative to the band edge emission of the bulk ZB InGaAs phase.

  5. Optical Characteristics of InAs Quantum Dots on GaAs Matrix by Using Various InGaAs Structures

    Institute of Scientific and Technical Information of China (English)

    KONG Lingmin; CAI Jiafa; WU Zhengyun; GONG Zheng; FANG Zhidan; NIU Zhichuan

    2006-01-01

    The effects of various InGaAs layers on the structural and optical properties of InAs self-assembled quantum dots(QDs) grown by molecular-beam epitaxy (MBE) were investigated. The emission wavelength of 1317 nm was obtained by embedding InAs QDs in InGaAs/GaAs quantum well. The temperature-dependent and timed-resolved photoluminescence (TDPL and TRPL) were used to study the dynamic characteristics of carriers. InGaAs cap layer may improve the quality of quantum dots for the strain relaxation around QDs, which results in a stronger PL intensity and an increase of PL peak lifetime up to 170 K. We found that InGaAs buffer layer may reduce the PL peak lifetime of InAs QDs, which is due to the buffer layer accelerating the carrier migration. The results also show that InGaAs cap layer can increase the temperature point when the thermal reemission and nonradiative recombination contribute significantly to the carrier dynamics.

  6. Bilateral connectivity in the somatosensory region using near-infrared spectroscopy (NIRS) by wavelet coherence

    Science.gov (United States)

    Fernandez Rojas, Raul; Huang, Xu; Ou, Keng-Liang

    2016-12-01

    Near-infrared spectroscopy (NIRS) has been used in medical imaging to obtain oxygenation and hemodynamic response in the cerebral cortex. This technique has been applied in cortical activation detection and functional connectivity in brain research. Despite some advances in functional connectivity, most of the studies have focused on the prefrontal cortex and little has been done to study the somatosensory region (S1). For that reason, the aim of our present study is to assess bilateral connectivity in the somatosensory region by using NIRS and noxious stimulation. Eleven healthy subjects were investigated using near-infrared spectroscopy during an acupuncture stimulation procedure to safely induce pain in subjects. A multiscale analysis based on wavelet transform coherence (WTC) was designed to assess the functional connectivity of corresponding channel pairs within the left and right s1 region. The cortical activation in the somatosensory region was higher after the acupuncture stimulation, which was consistent with similar studies. The coherence in time-frequency domain between homologous signals generated by contralateral channel pairs revealed two main periods (3.2 s and 12.8 s) with high coherence. Based on the WTC analysis, it was also found that the coherence increase in these periods was task-related. This study contributes to the research field to investigate cerebral hemodynamic response of pain perception using NIRS and demonstrates the use of wavelet transform as a method to investigate functional lateralization in the cerebral cortex.

  7. Complementary analysis of tissue homogenates composition obtained by Vis and NIR laser excitations and Raman spectroscopy

    Science.gov (United States)

    Staniszewska-Slezak, Emilia; Malek, Kamilla; Baranska, Malgorzata

    2015-08-01

    Raman spectroscopy and four excitation lines in the visible (Vis: 488, 532, 633 nm) and near infrared (NIR: 785 nm) were used for biochemical analysis of rat tissue homogenates, i.e. myocardium, brain, liver, lung, intestine, and kidney. The Vis Raman spectra are very similar for some organs (brain/intestines and kidney/liver) and dominated by heme signals when tissues of lung and myocardium were investigated (especially with 532 nm excitation). On the other hand, the NIR Raman spectra are specific for each tissue and more informative than the corresponding ones collected with the Vis excitations. The spectra analyzed without any special pre-processing clearly illustrate different chemical composition of each tissue and give information about main components e.g. lipids or proteins, but also about the content of some specific compounds such as amino acid residues, nucleotides and nucleobases. However, in order to obtain the whole spectral information about tissues complex composition the spectra of Vis and NIR excitations should be collected and analyzed together. A good agreement of data gathered from Raman spectra of the homogenates and those obtained previously from Raman imaging of the tissue cross-sections indicates that the presented here approach can be a method of choice for an investigation of biochemical variation in animal tissues. Moreover, the Raman spectral profile of tissue homogenates is specific enough to be used for an investigation of potential pathological changes the organism undergoes, in particular when supported by the complementary FTIR spectroscopy.

  8. Development of an inverted NIR-FT-Raman microscope for biomedical applications

    Science.gov (United States)

    Dippel, B.; Tatsch, E.; Schrader, B.

    1997-06-01

    NIR-FT-Raman spectroscopy is the most suitable tool for investigation of biological samples, because the fluorescence of organic substances is reduced to a minimum. To examine the applicability of NIR excited FT-Raman spectroscopy to the study of cell cultures and tissues, measurements were made with an inverted Raman microscope, a modified Zeiss Axiovert 135. This system allows the collection of Raman spectra both by Koehler laser illumination and the confocal principle: • Koehler laser illumination avoids overheating and denaturation of the sample because the exciting laser beam illuminates the sample as an unfocused collimated beam. An integrative collection over the whole image of the microscope objective is necessary to increase the Raman light flux. • The confocal arrangement allows high spatial resolution which is reached by selective collection of the Raman scattering of details of the sample. A larger spatial resolution leads to a decreased light flux of the Raman scattering, this is compensated by a focused laser beam. We have used NIR-FT-Raman spectroscopy to investigate the spectra of normal breast tissues, potentially useful in the diagnosis of cancer.

  9. Concurrent MR-NIR Imaging for Breast Cancer Diagnosis

    Science.gov (United States)

    2008-06-01

    is a fibroadenoma , which corresponds to a mass estimated to be 1−2 cm in diameter, and located 1 cm below the skin. Second case, Case 2, is an... fibroadenoma , which corresponds to a mass estimated to be 1–2 cm in diameter within a breast of 9 cm diameter located at 6–7 o’clock. Second case (case 2) is...Case 1 Fibroadenoma 1–2 cm 6–7 o‘clock Case 2 Adenocarcinoma 2–3 cm 4–5 o‘clock Case 3 Invasive ductal carcinoma 4 cm by 3 cm 6 o‘clock was derived a

  10. A spaceborne visible-NIR hyperspectral imager for coastal phenology

    Science.gov (United States)

    Osterman, Steven N.; Muller-Karger, Frank E.; Humm, David C.; Noble, Matthew W.; Begley, Shawn M.; Hersman, Christopher B.; Hestir, Erin L.; Izenberg, Noam; Keller, Mary R.; Lees, Jeff; Magruder, Adam S.; Morgan, Frank; Seifert, Helmut; Strohbehn, Kim

    2016-10-01

    The temporal variability, or phenology, of animals and plants in coastal zone and marine habitats is a function of geography and climatic conditions, of the chemical and physical characteristics of each particular habitat, and of interactions between these organisms. These conditions play an important role in defining the diversity of life. The quantitative study of phenology is required to protect and make wise use of wetland and other coastal resources. We describe a low cost space-borne sensor and mission concept that will enable such studies using high quality, broad band hyperspectral observations of a wide range of habitats at Landsat-class spatial resolution and with a 3 day or better revisit rate, providing high signal to noise observations for aquatic scenes and consistent view geometry for wetland and terrestrial vegetation scenes.

  11. EMIR, the GTC nir multi-object imager-spectrograph

    Directory of Open Access Journals (Sweden)

    F. Garzón

    2007-01-01

    Full Text Available EMIR, que esta actualmente cubriendo sus fases de fabricación y AIV, será uno de los primeros instrumentos de uso común en GTC el telescopio de 10m en construcción por GRANTECAN en el Observatorio del Roque de los Muchachos (Canarias, España. EMIR se construye por un consorcio de instituciones españolas y francesas, dirigido por el Instituto de Astrofísica de Canarias (IAC y está concebido para cubrir uno de los objetivos centrales de los telescopios de la clase de 10-m, el cual es obtener un gran número de espectros de fuentes débiles simultáneamente. EMIR está diseñado para operar principalmente como MOS en la banda K, aunque ofrece un amplio rango de modos de observación que incluyen imagen y espectroscopia, tanto de rendija larga como multiobjeto, en el rango espectral de 0.9 a 2.5 um. Está equipado con dos sistema novedosos en astronomía, que constituyen el corazón del instrumento: un robot reconfigurable de multimáscaras, de un lado, y elementos dispersivos formados por combinación de redes de difracción de alta calidad y prismas convencionales. Presentamos el estado actual de desarrollo, las prestaciones previstas y los planes iniciales para su explotación científica. Los desarrollos y fabricación de EMIR están financiados por GRANTECAN y el Plan Nacional de Astronomía y Astrofísica.

  12. EMIR, the GTC nir multi-object imager-spectrograph

    OpenAIRE

    Garzón, F.; D. Abreu; Barrera, S.; Correa, S.; J. J. Díaz; A. B. Fragoso; J. F. Fuentes; Gago, F.; C. González; López, P.; A. Manescau; J. Patrón; Pérez, J.; Redondo, P. (Pedro); Restrepo, R.

    2007-01-01

    EMIR, que esta actualmente cubriendo sus fases de fabricación y AIV, será uno de los primeros instrumentos de uso común en GTC el telescopio de 10m en construcción por GRANTECAN en el Observatorio del Roque de los Muchachos (Canarias, España). EMIR se construye por un consorcio de instituciones españolas y francesas, dirigido por el Instituto de Astrofísica de Canarias (IAC) y está concebido para cubrir uno de los objetivos centrales de los telescopios de la clase de 10-m, el cual...

  13. fNIRS measurements in migraine

    Science.gov (United States)

    Akin, Ata; Emir, Uzay E.; Bilensoy, Didem; Erdogan, Gulin; Candansyar, Selcuk; Bolay, Hayrunnisa

    2005-04-01

    Migraine is a complex chronic neurovascular disorder in which the interictal changes in neuronal excitability and vascular reactivity in the cerebral cortex were detected. The extent and direction of the changes in cerebral blood flow that affect cerebral hemodynamics during attacks, however, are still a matter of debate. This may have been due to the logistic and technical problems posed by the different techniques to determine cerebral blood flow during migraine attacks and the different definitions of patient populations. In this study, we have investigated hypercapnia challenges by breath holding task on subjects with and without migraine by using functional near infrared spectroscopy (fNIRS). Measurements of the relative changes in concentration of deoxy-hemoglobin [Hb] and oxy-hemoglobin [HbO2] are performed on four healthy subjects during three breath holdings of 30 seconds (s.) interleaved with 90 s. of normal breathing. We have observed [Hb]increase during breath holding interval in subject without migraine whereas in subject with migraine [Hb] decreases during breath holding interval. The result of our study suggest that hypercapnia effect on cerebral hemodynamic of subject with migraine and without migraine could be due to different vascular reactivity to PCO2 (carbon dioxide partial pressure) in arteries.

  14. Compensation techniques in NIRS proton beam radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Akanuma, A. (Univ. of Tokyo, Japan); Majima, H.; Furukawa, S.

    1982-09-01

    Proton beam has the dose distribution advantage in radiation therapy, although it has little advantage in biological effects. One of the best advantages is its sharp fall off of dose after the peak. With proton beam, therefore, the dose can be given just to cover a target volume and potentially no dose is delivered thereafter in the beam direction. To utilize this advantage, bolus techniques in conjunction with CT scanning are employed in NIRS proton beam radiation therapy planning. A patient receives CT scanning first so that the target volume can be clearly marked and the radiation direction and fixation method can be determined. At the same time bolus dimensions are calculated. The bolus frames are made with dental paraffin sheets according to the dimensions. The paraffin frame is replaced with dental resin. Alginate (a dental impression material with favorable physical density and skin surface contact) is now employed for the bolus material. With fixation device and bolus on, which are constructed individually, the patient receives CT scanning again prior to a proton beam treatment in order to prove the devices are suitable. Alginate has to be poured into the frame right before each treatments. Further investigations are required to find better bolus materials and easier construction methods.

  15. Hot electron induced NIR detection in CdS films.

    Science.gov (United States)

    Sharma, Alka; Kumar, Rahul; Bhattacharyya, Biplab; Husale, Sudhir

    2016-03-11

    We report the use of random Au nanoislands to enhance the absorption of CdS photodetectors at wavelengths beyond its intrinsic absorption properties from visible to NIR spectrum enabling a high performance visible-NIR photodetector. The temperature dependent annealing method was employed to form random sized Au nanoparticles on CdS films. The hot electron induced NIR photo-detection shows high responsivity of ~780 mA/W for an area of ~57 μm(2). The simulated optical response (absorption and responsivity) of Au nanoislands integrated in CdS films confirms the strong dependence of NIR sensitivity on the size and shape of Au nanoislands. The demonstration of plasmon enhanced IR sensitivity along with the cost-effective device fabrication method using CdS film enables the possibility of economical light harvesting applications which can be implemented in future technological applications.

  16. Identification of transgenic foods using NIR spectroscopy: A review

    Science.gov (United States)

    Alishahi, A.; Farahmand, H.; Prieto, N.; Cozzolino, D.

    2010-01-01

    The utilization of chemometric methods in the quantitative and qualitative analysis of feeds, foods, medicine and so on has been accompanied with the great evolution in the progress and in the near infrared spectroscopy (NIRS). Hence, recently the application of NIR spectroscopy has extended on the context of genetics and transgenic products. The aim of this review was to investigate the application of NIR spectroscopy to identificate transgenic products and to compare it with the traditional methods. The results of copious researches showed that the application of NIRS technology was successful to distinguish transgenic foods and it has advantages such as fast, avoiding time-consuming, non-destructive and low cost in relation to the antecedent methods such as PCR and ELISA.

  17. Systematization method for distinguishing plastic groups by using NIR spectroscopy.

    Science.gov (United States)

    Kaihara, Mikio; Satoh, Minami; Satoh, Minoru

    2007-07-01

    A systematic classification method for polymers is not yet available in case of using near infrared spectra (NIR). That is why we have been searching for a systematic method. Because raw NIR spectra usually have few obvious peaks, NIR spectra have been pretreated by 2nd derivation for taking well modulated spectra. After the pretreatment, we applied classification and regression trees (CART) to the discrimination between the spectra and the species of polymers. As a result, we obtained a relatively simple classification tree. Judging from the obtained splitting conditions and the classified polymers, we concluded that obtained knowledge on the chemical function groups estimated by the important wavelength regions is not always applicable to this classification tree. However, we clarified the splitting rules for polymer species from the NIR spectral point of view.

  18. Water-soluble pyrrolopyrrole cyanine (PPCy) NIR fluorophores.

    Science.gov (United States)

    Wiktorowski, Simon; Rosazza, Christelle; Winterhalder, Martin J; Daltrozzo, Ewald; Zumbusch, Andreas

    2014-05-11

    Water-soluble derivatives of pyrrolopyrrole cyanines (PPCys) have been synthesized by a post-synthetic modification route. In highly polar media, these dyes are excellent NIR fluorophores. Labeling experiments show how these novel dyes are internalized into mammalian cells.

  19. NIR emitting ytterbium chelates for colourless luminescent solar concentrators.

    Science.gov (United States)

    Sanguineti, Alessandro; Monguzzi, Angelo; Vaccaro, Gianfranco; Meinardi, Franco; Ronchi, Elisabetta; Moret, Massimo; Cosentino, Ugo; Moro, Giorgio; Simonutti, Roberto; Mauri, Michele; Tubino, Riccardo; Beverina, Luca

    2012-05-14

    A new oxyiminopyrazole-based ytterbium chelate enables NIR emission upon UV excitation in colorless single layer luminescent solar concentrators for building integrated photovoltaics. This journal is © the Owner Societies 2012

  20. NIRS Characterization of Paper Pulps to Predict Kappa Number

    Directory of Open Access Journals (Sweden)

    Ana Moral

    2015-01-01

    Full Text Available Rice is one of the most abundant food crops in the world and its straw stands as an important source of fibres both from an economic and an environmental point of view. Pulp characterization is of special relevance in works involving alternative raw materials, since pulp properties are closely linked to the quality of the final product. One of the analytical techniques that can be used in pulp characterization is near-infrared spectroscopy (NIRS. The use of NIRS has economic and technical advantages over conventional techniques. This paper aims to discuss the convenience of using NIRS to predict Kappa number in rice straw pulps produced under different conditions. We found that the resulting Kappa number can be acceptably estimated by NIRS, as the errors obtained with that method are similar to those found for other techniques.

  1. Single-trial classification of NIRS signals during emotional induction tasks: towards a corporeal machine interface

    Directory of Open Access Journals (Sweden)

    Tai Kelly

    2009-11-01

    Full Text Available Abstract Background Corporeal machine interfaces (CMIs are one of a few available options for restoring communication and environmental control to those with severe motor impairments. Cognitive processes detectable solely with functional imaging technologies such as near-infrared spectroscopy (NIRS can potentially provide interfaces requiring less user training than conventional electroencephalography-based CMIs. We hypothesized that visually-cued emotional induction tasks can elicit forehead hemodynamic activity that can be harnessed for a CMI. Methods Data were collected from ten able-bodied participants as they performed trials of positively and negatively-emotional induction tasks. A genetic algorithm was employed to select the optimal signal features, classifier, task valence (positive or negative emotional value of the stimulus, recording site, and signal analysis interval length for each participant. We compared the performance of Linear Discriminant Analysis and Support Vector Machine classifiers. The latency of the NIRS hemodynamic response was estimated as the time required for classification accuracy to stabilize. Results Baseline and activation sequences were classified offline with accuracies upwards of 75.0%. Feature selection identified common time-domain discriminatory features across participants. Classification performance varied with the length of the input signal, and optimal signal length was found to be feature-dependent. Statistically significant increases in classification accuracy from baseline rates were observed as early as 2.5 s from initial stimulus presentation. Conclusion NIRS signals during affective states were shown to be distinguishable from baseline states with classification accuracies significantly above chance levels. Further research with NIRS for corporeal machine interfaces is warranted.

  2. A 260 megapixel visible/NIR mixed technology focal plane for space

    Science.gov (United States)

    Besuner, Robert W.; Bebek, Christopher J.; Haller, Gunther M.; Harris, Stewart E.; Hart, Philip A.; Heetderks, Henry D.; Jelinsky, Patrick N.; Lampton, Michael L.; Levi, Michael E.; Maldonado, Sergio E.; Roe, Natalie A.; Roodman, Aaron J.; Sapozhnikov, Leonid

    2011-10-01

    Mission concepts for NASA's Wide Field Infrared Survey Telescope (WFIRST)1,2, ESA's Euclid3,4 mission, as well as next-generation ground-based surveys require large mosaic focal planes sensitive in both visible and near infrared (NIR) wavelengths. We have developed space-qualified detectors, readout electronics and focal plane design techniques that can be used to intermingle CCDs and NIR detectors on a single, silicon carbide (SiC) cold plate. This enables optimized, wideband observing strategies. The CCDs, developed at Lawrence Berkeley National Laboratory, are fully-depleted, pchannel devices that are backside illuminated and capable of operating at temperatures down to 120K. The NIR detectors are 1.7 μm and 2.0 μm wavelength cutoff H2RG® HgCdTe, manufactured by Teledyne Imaging Sensors under contract to LBNL. Both the CCDs and NIR detectors are packaged on 4-side abuttable SiC pedestals with a common mounting footprint supporting a 44 mm mosaic pitch. Both types of detectors have direct-attached readout electronics that convert the detector signal directly to serial, digital data streams and allow a flexible, low cost data acquisition strategy to enable large data rates. A mosaic of these detectors can be operated at a common temperature that achieves the required dark current and read noise performance necessary for dark energy observations. We report here the qualification testing and performance verification for a focal plane that accommodates a 4x8 array of CCDs and HgCdTe detectors.

  3. Growth and properties of In(Ga)As nanowires on silicon

    Energy Technology Data Exchange (ETDEWEB)

    Hertenberger, Simon

    2012-10-15

    nanowire properties and homogeneous array-like characteristics. High vertical growth yields of 90 % are achieved on substrates patterned either by e-beam lithography (for small scale arrays) or nanoimprint lithography (NIL, for large scale arrays > 5 x 5 mm{sup 2}). In addition, X-ray rocking curve measurements evidence very low crystal tilt and perfect vertical alignment along the (111) direction with full widths at half maximum (FWHM) as low as 0.6 . Furthermore, systematic investigations of the size scaling behavior as a function of the pitch (interwire distance) highlight the existence of two growth regimes: (i) a competitive growth regime for narrow pitches and (ii) a diffusion-limited regime for wider pitches, where growth is limited by the diffusion length of In adatoms on the SiO{sub 2} surface (∝750 nm at T=480 C). Furthermore, the growth of ternary InGaAs nanowires on sputter-deposited SiO{sub x}/Si(111) and NIL-patterned SiO{sub 2}/Si(111) substrates is investigated. Here, composition tuning with Ga contents ranging from 0-60 % was achieved as confirmed by X-ray diffraction and energy dispersive X-ray spectroscopy. Furthermore, the two different growth strategies are compared yielding a significantly lower FWHM of the 2θ-XRD-peak in the case of NIL-patterned substrates (0.031 ) as compared to self-assembled grown nanowires (0.084 ). This finding is further supported by Raman spectroscopy showing lower longitudinal optical to transversal optical (LO/TO) intensity ratios and lower LO-FWHM for both the InAs-like and GaAs-like LO modes in the case of NIL-patterned nanowire growth. These observations indicate superior composition homogeneity for positioned nanowire growth on patterned substrates. In addition, low-T photoluminescence (PL) measurements are presented showing band gap tuning over a wavelength range of ∝1800-2850 nm where PL peak linewidths are as narrow as ∝30 meV, independent of the Ga content. Finally, the effect of growth parameters on the

  4. NIR Electrofluorochromic Properties of Aza-Boron-dipyrromethene Dyes

    OpenAIRE

    2016-01-01

    The photophysical properties of near-infrared (NIR) emissive aza-boron-dipyrromethene (aza-BDP) dyes incorporating nitrofluorene and alkoxy decorations were intensively investigated. Their highly reversible one-electron reduction process showed characteristic electrofluorochromic (EF) properties in the NIR range, depending on the substituents. The nitrofluorene ethynyl-substituted (Type I) dyes showed smaller EF effects than the alkoxy-containing (Type II) dyes because of the difference in th...

  5. Brain Functional Connectivity in MS: An EEG-NIRS Study

    Science.gov (United States)

    2015-10-01

    oxygen- based ( near -infrared spectroscopy (NIRS), functional MRI (fMRI)) signals, and to use the results to help optimize BOLD fMRI analyses of brain...2. Keywords BOLD – blood oxygen level dependent EEG – electroencephalography NIRS – near -infrared spectroscopy fMRI – functional MRI MS...INTRODUCTION TO ELECTROENCEPHALOGRAPHY AND NEAR -INFRARED SPECTROSCOPY NEUROIMAGING MEASUREMENT AND ANALYSIS P.40LO GlACO~lETTT 1. COURSE O VERVIEW T he

  6. Cerebral blood volume in humans by NIRS and PET

    Science.gov (United States)

    Pott, Frank; Knudsen, Gitte M.; Rostrup, Egill; Ide, Kojiro; Secher, Niels H.; Paulson, Olaf B.

    1998-01-01

    Near infrared spectroscopy (NIRS) determined changes in the cerebral blood volume (CBV) were compared to those obtained by positron emission tomography (PET) in five healthy volunteers (2 females). Two NIRS optodes were placed on the left forehead and NIRS-CBV was derived from the sum of oxyhemoglobin and deoxyhemoglobin. CBV changes were induced by hyperventilation and inhalation of 6% CO2. After 2 min inhalation of labeled carbon monoxide, data were sampled during 8 min for both PET- and NIRS-CBV as well as for the arterial carbon dioxide tension (PaCO2). The region of interest for PET-CBV was `banana-shaped' with boundaries corresponding to the position of the NIRS optodes on the transmission scan and to a depth of approximately 2 cm. During hyperventilation, PaCO2 decreased from 5.2 (4.6 - 5.8) to 4.6 (4.2 - 4.9) kPa and equally PET-CBV (from 3.9 (2.5 - 5.2) to 3.6 (3.0 - 4.8) ml (DOT) 100 g-1) and NIRS-CBV were reduced (by -0.14 [-0.38 - 0.50] ml (DOT) 100 g-1). During hypercapnia PaCO2 increased to 6.0 (5.9 - 7.0) kPa accompanied by parallel changes in PET- (to 4.5 (3.9 - 4.9) ml (DOT) 100 g-1) and NIRS-CBV (by 0.04 [-0.02 - 0.30] ml (DOT) 100 g-1) and the two variables were correlated (r equals 0.78, p arterial carbon dioxide tension, the cerebral blood volumes determined by near infrared spectroscopy and by positron emission tomography change in parallel but the change in NIRS-CBV is small compared to that obtained by PET.

  7. Toward Adaptation of fNIRS Instrumentation to Airborne Environments

    Science.gov (United States)

    Adamovsky, Grigory; Mackey, Jeffrey; Harrivel, Angela; Hearn, Tristan; Floyd, Bertram

    2014-01-01

    The paper reviews potential applications of functional Near-Infrared Spectroscopy (fNIRS), a well-known medical diagnostic technique, to monitoring the cognitive state of pilots with a focus on identifying ways to adopt this technique to airborne environments. We also discuss various fNIRS techniques and the direction of technology maturation of associated hardware in view of their potential for miniaturization, maximization of data collection capabilities, and user friendliness.

  8. Emerging Multifunctional NIR Photothermal Therapy Systems Based on Polypyrrole Nanoparticles

    OpenAIRE

    Mozhen Wang

    2016-01-01

    Near-infrared (NIR)-light-triggered therapy platforms are now considered as a new and exciting possibility for clinical nanomedicine applications. As a promising photothermal agent, polypyrrole (PPy) nanoparticles have been extensively studied for the hyperthermia in cancer therapy due to their strong NIR light photothermal effect and excellent biocompatibility. However, the photothermal application of PPy based nanomaterials is still in its preliminary stage. Developing PPy based multifuncti...

  9. Near-IR imaging and imaging polarimetry of OMC 2

    Science.gov (United States)

    Rayner, John; Mclean, Ian; Aspin, Colin; Mccaughrean, Mark

    1989-01-01

    NIR and 2.2-micron imaging polarimetry of the molecular cloud region OMC 2, reveals a cluster of low- to intermediate-mass premain-sequence stars embedded in circumstellar disks. The 2.2-micron imaging polarimetry indicates that the compact NIR sources OMC 2 IRS1, IRS2, IRS3 and IRS4 N, are illumination centers for the surrounding extended emission. By application of Hubble's relation to the nebulae illuminated by IRS1, IRS2 and IRS4 N, the illuminating geometry is explained and the intrinsic NIR colors of these objects are estimated.

  10. Near-IR imaging and imaging polarimetry of OMC 2

    Science.gov (United States)

    Rayner, John; Mclean, Ian; Aspin, Colin; Mccaughrean, Mark

    1989-01-01

    NIR and 2.2-micron imaging polarimetry of the molecular cloud region OMC 2, reveals a cluster of low- to intermediate-mass premain-sequence stars embedded in circumstellar disks. The 2.2-micron imaging polarimetry indicates that the compact NIR sources OMC 2 IRS1, IRS2, IRS3 and IRS4 N, are illumination centers for the surrounding extended emission. By application of Hubble's relation to the nebulae illuminated by IRS1, IRS2 and IRS4 N, the illuminating geometry is explained and the intrinsic NIR colors of these objects are estimated.

  11. Novel INHAT repressor (NIR) is required for early lymphocyte development.

    Science.gov (United States)

    Ma, Chi A; Pusso, Antonia; Wu, Liming; Zhao, Yongge; Hoffmann, Victoria; Notarangelo, Luigi D; Fowlkes, B J; Jain, Ashish

    2014-09-23

    Novel inhibitor of histone acetyltransferase repressor (NIR) is a transcriptional corepressor with inhibitor of histone acetyltransferase activity and is a potent suppressor of p53. Although NIR deficiency in mice leads to early embryonic lethality, lymphoid-restricted deletion resulted in the absence of double-positive CD4(+)CD8(+) thymocytes, whereas bone-marrow-derived B cells were arrested at the B220(+)CD19(-) pro-B-cell stage. V(D)J recombination was preserved in NIR-deficient DN3 double-negative thymocytes, suggesting that NIR does not affect p53 function in response to physiologic DNA breaks. Nevertheless, the combined deficiency of NIR and p53 provided rescue of DN3L double-negative thymocytes and their further differentiation to double- and single-positive thymocytes, whereas B cells in the marrow further developed to the B220(+)CD19(+) pro-B-cell stage. Our results show that NIR cooperate with p53 to impose checkpoint for the generation of mature B and T lymphocytes.

  12. A Clinical Tissue Oximeter Using NIR Time-Resolved Spectroscopy.

    Science.gov (United States)

    Fujisaka, Shin-ichi; Ozaki, Takeo; Suzuki, Tsuyoshi; Kamada, Tsuyoshi; Kitazawa, Ken; Nishizawa, Mitsunori; Takahashi, Akira; Suzuki, Susumu

    2016-01-01

    The tNIRS-1, a new clinical tissue oximeter using NIR time-resolved spectroscopy (TRS), has been developed. The tNIRS-1 measures oxygenated, deoxygenated and total hemoglobin and oxygen saturation in living tissues. Two-channel TRS measurements are obtained using pulsed laser diodes (LD) at three wavelengths, multi-pixel photon counters (MPPC) for light detection, and time-to-digital converters (TDC) for time-of-flight photon measurements. Incorporating advanced semiconductor devices helped to make the design of this small-size, low-cost and low-power TRS instrument possible. In order to evaluate the correctness and reproducibility of measurement data obtained with the tNIRS-1, a study using blood phantoms and healthy volunteers was conducted to compare data obtained from a conventional SRS device and data from an earlier TRS system designed for research purposes. The results of the study confirmed the correctness and reproducibility of measurement data obtained with the tNIRS-1. Clinical evaluations conducted in several hospitals demonstrated a high level of usability in clinical situations and confirmed the efficacy of measurement data obtained with the tNIRS-1.

  13. Light-trapping for room temperature Bose-Einstein condensation in InGaAs quantum wells.

    Science.gov (United States)

    Vasudev, Pranai; Jiang, Jian-Hua; John, Sajeev

    2016-06-27

    We demonstrate the possibility of room-temperature, thermal equilibrium Bose-Einstein condensation (BEC) of exciton-polaritons in a multiple quantum well (QW) system composed of InGaAs quantum wells surrounded by InP barriers, allowing for the emission of light near telecommunication wavelengths. The QWs are embedded in a cavity consisting of double slanted pore (SP2) photonic crystals composed of InP. We consider exciton-polaritons that result from the strong coupling between the multiple quantum well excitons and photons in the lowest planar guided mode within the photonic band gap (PBG) of the photonic crystal cavity. The collective coupling of three QWs results in a vacuum Rabi splitting of 3% of the bare exciton recombination energy. Due to the full three-dimensional PBG exhibited by the SP2 photonic crystal (16% gap to mid-gap frequency ratio), the radiative decay of polaritons is eliminated in all directions. Due to the short exciton-phonon scattering time in InGaAs quantum wells of 0.5 ps and the exciton non-radiative decay time of 200 ps at room temperature, polaritons can achieve thermal equilibrium with the host lattice to form an equilibrium BEC. Using a SP2 photonic crystal with a lattice constant of a = 516 nm, a unit cell height of 2a=730nm and a pore radius of 0.305a = 157 nm, light in the lowest planar guided mode is strongly localized in the central slab layer. The central slab layer consists of 3 nm InGaAs quantum wells with 7 nm InP barriers, in which excitons have a recombination energy of 0.944 eV, a binding energy of 7 meV and a Bohr radius of aB = 10 nm. We take the exciton recombination energy to be detuned 35 meV above the lowest guided photonic mode so that an exciton-polariton has a photonic fraction of approximately 97% per QW. This increases the energy range of small-effective-mass photonlike states and increases the critical temperature for the onset of a Bose-Einstein condensate. With three quantum wells in the central slab layer

  14. Highly diverse nirK genes comprise two major clades that harbour ammonium-producing denitrifiers

    OpenAIRE

    2016-01-01

    Background Copper dependent nitrite reductase, NirK, catalyses the key step in denitrification, i.e. nitrite reduction to nitric oxide. Distinct structural NirK classes and phylogenetic clades of NirK-type denitrifiers have previously been observed based on a limited set of NirK sequences, however, their environmental distribution or ecological strategies are currently unknown. In addition, environmental nirK-type denitrifiers are currently underestimated in PCR-dependent surveys due to prime...

  15. NIR spectroscopy of the Sun and HD20010 - Compiling a new linelist in the NIR

    CERN Document Server

    Andreasen, D T; Mena, E Delgado; Santos, N C; Tsantaki, M; Rojas-Ayala, B; Neves, V

    2016-01-01

    Context: Effective temperature, surface gravity, and metallicity are basic spectroscopic stellar parameters necessary to characterize a star or a planetary system. Reliable atmospheric parameters for FGK stars have been obtained mostly from methods that relay on high resolution and high signal-to-noise optical spectroscopy. The advent of a new generation of high resolution near-IR spectrographs opens the possibility of using classic spectroscopic methods with high resolution and high signal-to-noise in the NIR spectral window. Aims: We aim to compile a new iron line list in the NIR from a solar spectrum to derive precise stellar atmospheric parameters, comparable to the ones already obtained from high resolution optical spectra. The spectral range covers 10 000 {\\AA} to 25 000 {\\AA}, which is equivalent to the Y, J, H, and K bands. Methods: Our spectroscopic analysis is based on the iron excitation and ionization balance done in LTE. We use a high resolution and high signal-to-noise ratio spectrum of the Sun ...

  16. Brain activity underlying the recovery of meaning from degraded speech: A functional near-infrared spectroscopy (fNIRS) study.

    Science.gov (United States)

    Wijayasiri, Pramudi; Hartley, Douglas E H; Wiggins, Ian M

    2017-08-01

    The purpose of this study was to establish whether functional near-infrared spectroscopy (fNIRS), an emerging brain-imaging technique based on optical principles, is suitable for studying the brain activity that underlies effortful listening. In an event-related fNIRS experiment, normally-hearing adults listened to sentences that were either clear or degraded (noise vocoded). These sentences were presented simultaneously with a non-speech distractor, and on each trial participants were instructed to attend either to the speech or to the distractor. The primary region of interest for the fNIRS measurements was the left inferior frontal gyrus (LIFG), a cortical region involved in higher-order language processing. The fNIRS results confirmed findings previously reported in the functional magnetic resonance imaging (fMRI) literature. Firstly, the LIFG exhibited an elevated response to degraded versus clear speech, but only when attention was directed towards the speech. This attention-dependent increase in frontal brain activation may be a neural marker for effortful listening. Secondly, during attentive listening to degraded speech, the haemodynamic response peaked significantly later in the LIFG than in superior temporal cortex, possibly reflecting the engagement of working memory to help reconstruct the meaning of degraded sentences. The homologous region in the right hemisphere may play an equivalent role to the LIFG in some left-handed individuals. In conclusion, fNIRS holds promise as a flexible tool to examine the neural signature of effortful listening. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Does the source of carbon influence the abundance of nirK, nirS and nosZ functional genes in laboratory denitrification bioreactors?

    Science.gov (United States)

    Barrett, Maria; Fenton, Owen; Ibrahim, Tristan G.; O'Flaherty, Vincent; Healey, Mark G.

    2014-05-01

    Biological denitrification in soil is the main producer of nitrous oxide (N2O) emissions. Denitrifying soil microbes are capable of reducing nitrate (NO3-) to nitrite (NO2-) to N2O and di-nitrogen gas (N2). One third of these denitrifers possess a truncated functional gene pathway, which may lack the nosZ gene and emit N2O as a final emission product instead of the more benign N2. A carbon rich environment, specific to certain types of carbon sources, has been shown to foster an anaerobic environment, which positively impacts microbial denitrification rates. The present study examined the effect of varying carbon sources in laboratory-scale denitrification bioreactors on NO3- removal and also correlated performance with the abundance of the denitrifying microbial consortia possessing the denitrifying functional genes nirK, nirS and nosZ in each bioreactor. The bioreactors comprised either lodgepole pine woodchips (LPW), lodgepole pine needles (LPN), barley straw (BBS), or cardboard (CCB), each mixed with soil in a 1:1 ratio (by volume) and subject to sequentially increasing hydraulic loading rates of 3, 5 and 10 cm d-1 for a total operation period of up to 744 days. A reactor containing soil only (CSO) was used as the study control. The abundance of denitrifers was determined by targeting nirK, nirS, nosZ functional genes and the overall microbial population was determined by targeting bacterial and archaeal 16sRNA genes. Nitrate removal from all bioreactors was > 99.7%, but when pollution swapping was considered, this ranged from 67% for LPW to 95% for the CCB ; this was also mirrored in the average nirk/nirS/nosZ gene abundance (CCB, c. 94% (c. 108); LPN, 75% (c. 107); BBS, c. 74% (c. 106/107); LPW, 70% (c. 105). Bacterial 16sRNA gene abundance was similar in all reactors including the control (P=0.0362). The abundance of nosZ genes and the genetic potential for N2 emissions varied in all reactors in comparison to the control CSO, BBS (P=0.0051); CCB (P=0

  18. Effect of Sensitivity Improvement of Visible to NIR Digital Cameras on NDVI Measurements in Particular for Agricultural Field Monitoring

    Directory of Open Access Journals (Sweden)

    Kohei Arai

    2015-12-01

    Full Text Available Effect of sensitivity improvement of Near Infrared: NIR digital cameras on Normalized Difference Vegetation Index: NDVI measurements in particular for agricultural field monitoring is clarified. Comparative study is conducted between sensitivity improved visible to near infrared camera of CuInGaSe: CIGS and the conventional camera. Signal to Noise: S/N ratio and sensitivity are evaluated with NIR camera data which are acquired in tea farm areas and rice paddy fields. From the experimental results, it is found that S/N ratio of the conventional digital camera with NIR wavelength coverage is better than CIGS utilized image sensor while the sensitivity of the CIGS image sensor is much superior to that of the conventional camera. Also, it is found that NDVI derived from the CIGS image sensor is much better than that from the conventional camera due to the fact that the sensitivity of the CIGS image sensor in red color wavelength region is much better than that of the conventional camera.

  19. From structure to spectra. Tight-binding theory of InGaAs quantum dots

    Energy Technology Data Exchange (ETDEWEB)

    Goldmann, Elias

    2014-07-23

    counterintuitively. Our result demonstrates the applicability of InGaAs quantum dots for quantum telecommunication at the desired telecom wavelengths, offering good growth controllability. For the application in lasers, quantum based active media are known to offer superior properties to common quantum well lasers such as low threshold currents or temperature stability. For device design, the knowledge about the saturation behaviour of optical gain with excitation density is of major importance. In the present work we combine quantum-kinetic models for the calculation of the optical gain of quantum dot active media with our atomistic tight-binding model for the calculation of single-particle energies and wave functions. We investigate the interplay between structural properties of the quantum dots and many-body effects in the optical gain spectra and identify different regimes of saturation behaviour. Either phase-space filling dominates the excitation dependence of the optical gain, leading to saturation, or excitation-induced dephasing dominates the excitation dependence of the optical gain, resulting in a negative differential gain.

  20. Sensitivity and noise of micro-Hall magnetic sensors based on InGaAs quantum wells

    Science.gov (United States)

    Chenaud, B.; Segovia-Mera, A.; Delgard, A.; Feltin, N.; Hoffmann, A.; Pascal, F.; Zawadzki, W.; Mailly, D.; Chaubet, C.

    2016-01-01

    We study the room-temperature performance of micro-Hall magnetic sensors based on pseudomorphic InGaAs quantum wells. Active areas of our sensors range from 1 to 80 μm. We focus on the smallest detectable magnetic fields in small sensors and perform a systematic study of noise at room temperature in the frequency range between 1 Hz and 100 kHz. Our data are interpreted by the mobility fluctuation model. The Hooge parameter is determined for the applied technology. We show that, independently of the experimental frequency, the ratio of sensitivity to noise is proportional to characteristic length of the sensor. The resolution of 1 mG/√{Hz } is achievable in a 3 μm sensor at room temperature.

  1. Cavity quantum electrodynamics studies with site-controlled InGaAs quantum dots integrated into high quality microcavities

    DEFF Research Database (Denmark)

    Reitzenstein, S.; Schneider, C.; Albert, F.

    2011-01-01

    , e.g., the large scale fabrication of quantum light sources. As a result, large efforts focus on the growth and the device integration of site-controlled QDs. We present the growth of low density arrays of site-controlled In(Ga)As QDs where shallow etched nanoholes act as nucleation sites......Semiconductor quantum dots (QDs) are fascinating nanoscopic structures for photonics and future quantum information technology. However, the random position of self-organized QDs inhibits a deterministic coupling in devices relying on cavity quantum electrodynamics (cQED) effects which complicates....... The nanoholes are located relative to cross markers which allows for a precise spatial alignment of the site-controlled QDs (SCQDs) and the photonic modes of high quality microcavites with an accuracy better than 50 nm. We also address the optical quality of the SCQDs in terms of the single SCQD emission mode...

  2. Band offset in GaAlAs and InGaAs: InP heterojunctions by electrochemical CV profiling

    Science.gov (United States)

    Furtado, M. T.; Loural, M. S. S.; Sachs, A. C.; Shieh, P. J.

    We report electrochemical CV measurement determination of the conduction band offset ΔEc of Ga 1-xAl xAs:Ga 1-yAl yAs heterojunctions (HJs) with x=0-0.21 and y≈0.4, as well as of In 0.53Ga 0.47As: InP HJs. The samples were grown by liquid phase epitaxy. We have obtained band offset ratios ΔEc/ΔEg≈0.6 and ΔEc/ΔEg≈0.36, respectively, for GaAlAs and InGaAs: InP HJs, where ΔEg is the HJ band gap energy difference. These results are consistent with recent data obtained by other techniques on similar HJs. In addition, the density of fixed interface charges are estimated and are apparently related to the doping of the large band gap layer of the HJ.

  3. Indium and gallium diffusion through zirconia in the TiN/ZrO{sub 2}/InGaAs stack

    Energy Technology Data Exchange (ETDEWEB)

    Ceballos-Sanchez, O. [CINVESTAV-Unidad Queretaro, Queretaro, Qro. 76230 (Mexico); Univ. Grenoble Alpes, F-38000 Grenoble, France and CEA, LETI, MINATEC Campus, F-38054 Grenoble (France); Martinez, E.; Guedj, C.; Veillerot, M. [Univ. Grenoble Alpes, F-38000 Grenoble, France and CEA, LETI, MINATEC Campus, F-38054 Grenoble (France); Herrera-Gomez, A. [CINVESTAV-Unidad Queretaro, Queretaro, Qro. 76230 (Mexico)

    2015-06-01

    Angle-resolved X-ray Photoelectron Spectroscopy (ARXPS) was applied to the TiN/ZrO{sub 2}/InGaAs stack to assess its thermal stability. Through a robust ARXPS analysis, it was possible to observe subtle effects such as the thermally induced diffusion of substrate atomic species (In and Ga) through the dielectric layer. The detailed characterization of the film structure allowed for assessing the depth profiles of the diffused atomic species by means of the scenarios-method. Since the quantification for the amount of diffused material was done at different temperatures, it was possible to obtain an approximate value of the activation energy for the diffusion of indium through zirconia. The result is very similar to the previously reported values for indium diffusion through alumina and through hafnia.

  4. NIR and optical observations of the failed outbursts of black hole binary XTE J1550-564

    CERN Document Server

    Curran, P A

    2013-01-01

    A number of low mass X-ray binaries (LMXBs) undergo "failed outbursts" in which, instead of evolving through the canonical states, they remain in a hard state throughout the outburst. While the sources of X-ray and radio emission in the hard state are relatively well understood, the origin of the near infrared (NIR) and optical emission is more complex though it likely stems from an amalgam of different emission processes, occurring as it does, at the intersecting wavelengths of those processes. We aim to identify the NIR/optical emission region(s) during a number of failed outbursts of one such low mass X-ray binary and black hole candidate, XTE J1550-564, in order to confirm or refute their classification as hard-state, failed outbursts. We present unique NIR/optical images and spectra, obtained with the ESO-New Technology Telescope, during the failed outbursts of 2001 and 2000. We compare the NIR/optical photometric, timing, and spectral properties with those expected for the different emission mechanisms ...

  5. Online characterization of laser beam welds by NIR-camera observation

    Science.gov (United States)

    Dorsch, Friedhelm; Braun, Holger; Keßler, Steffen; Pfitzner, Dieter; Rominger, Volker

    2013-02-01

    We have investigated process monitoring of laser beam welding with a TruDisk disk laser to detect process faults. Additionally to monitoring laser beam welding processes by a conventional VIS camera an NIR (near-infrared) camera reveals new information. Our sensor detects thermal radiation between 1100 and 1700 nm from the weld zone, which represents surface temperatures above 1000 K. Using the thermal radiation from the process we can observe all major weld defects without auxiliary illumination. The camera is integrated in a standard TRUMPF welding optics for on-axis observation. A real-time image processing system analyzes the camera images regarding welding irregularities and delivers information to characterize the weld process and its result. Actually, we perform an online passive heat-flow thermography that uses the process itself as the heat source and that probes the thermal attributes of the seam. By this means we can detect regions of bad fusion ("false friends") virtually during the welding process. In addition to conventional thermography we have investigated the use of ratio pyrometry by using to NIR-cameras that observe the process in two different spectral bands. By considering the pixel-per-pixel ratio the influence of surface effects it greatly reduces and we obtain images of the weld zone with an absolute temperature scale. We have compared ratio pyrometry measurements with conventional thermography.

  6. Direct Measurements of Fermi Level Pinning at the Surface of Intrinsically n-Type InGaAs Nanowires.

    Science.gov (United States)

    Speckbacher, Maximilian; Treu, Julian; Whittles, Thomas J; Linhart, Wojciech M; Xu, Xiaomo; Saller, Kai; Dhanak, Vinod R; Abstreiter, Gerhard; Finley, Jonathan J; Veal, Tim D; Koblmüller, Gregor

    2016-08-10

    Surface effects strongly dominate the intrinsic properties of semiconductor nanowires (NWs), an observation that is commonly attributed to the presence of surface states and their modification of the electronic band structure. Although the effects of the exposed, bare NW surface have been widely studied with respect to charge carrier transport and optical properties, the underlying electronic band structure, Fermi level pinning, and surface band bending profiles are not well explored. Here, we directly and quantitatively assess the Fermi level pinning at the surfaces of composition-tunable, intrinsically n-type InGaAs NWs, as one of the prominent, technologically most relevant NW systems, by using correlated photoluminescence (PL) and X-ray photoemission spectroscopy (XPS). From the PL spectral response, we reveal two dominant radiative recombination pathways, that is, direct near-band edge transitions and red-shifted, spatially indirect transitions induced by surface band bending. The separation of their relative transition energies changes with alloy composition by up to more than ∼40 meV and represent a direct measure for the amount of surface band bending. We further extract quantitatively the Fermi level to surface valence band maximum separation using XPS, and directly verify a composition-dependent transition from downward to upward band bending (surface electron accumulation to depletion) with increasing Ga-content x(Ga) at a crossover near x(Ga) ∼ 0.2. Core level spectra further demonstrate the nature of extrinsic surface states being caused by In-rich suboxides arising from the native oxide layer at the InGaAs NW surface.

  7. Rapid Discrimination of Chlorpheniramine Maleate and Assessment of Its Surface Content Uniformity in a Pharmaceutical Formulation by NIR-CI Coupled with Statistical Measurement

    Directory of Open Access Journals (Sweden)

    Luwei Zhou

    2014-01-01

    Full Text Available This study demonstrated that near infrared chemical imaging (NIR-CI was a rapid and nondestructive technique for discrimination of chlorpheniramine maleate (CPM and assessment of its surface content uniformity (SCU in a pharmaceutical formulation. The characteristic wavenumber method was used for discriminating CPM distribution on the tablet surface. To assess the surface content uniformity of CPM, binary image and statistical measurement were proposed. Furthermore, high-performance liquid chromatography (HPLC was used as reference method for accurately determining volume content of CPM in the sample. Moreover, HPLC was performed to assess volume content uniformity (VCU of CPM in whole region and part region of the tablets. The NIR-CI result showed that the spatial distribution of CPM was heterogeneous on the tablet surface. Through the comparison of content uniformity of CPM determined by NIR-CI and HPLC, respectively, it demonstrated that a high degree of VCU did not imply a high degree of SCU of the samples. These results indicate that HPLC method is not suitable for testing SCU, and this has been verified by NIR-CI. This study proves the feasibility of NIR-CI for rapid discrimination of CPM and assessment of its SCU, which is helpful for the quality control of commercial CPM tablets.

  8. Preliminary study on nitrite degradation by nirS recombinant genetic engineering bacteria%nirS基因重组工程菌降解亚硝酸盐的初步研究

    Institute of Scientific and Technical Information of China (English)

    杨兴兴; 陈学萍; 刘冬秀; 沈洁; 陆永生

    2014-01-01

    通过基因工程手段增加厌氧氨氧化菌亚硝酸盐还原酶(nitrite reductase, nirS)的表达量,运用质粒载体pGEM-T克隆nirS基因。琼脂糖凝胶电泳检测显示, nirS基因重组工程菌在440 bp处有明显的目的条带; nirS基因重组工程菌扩大培养7~8h后即达到生长曲线稳定期,引入外加氮源后,菌体生长情况更优。通过不同菌液投加量以及处理不同初始浓度的亚硝酸钠溶液,检测nirS基因重组工程菌的性能。结果表明,当nirS基因重组工程菌投加30 mL(细菌数为2.3×107个∕mL),亚硝酸盐初始质量浓度为40 mg∕L时,亚硝酸盐去除率达到90%以上。nirS基因重组工程菌可适用于亚硝酸盐废水的处理。%In order to improve the expression quantity of nitrite reductase (nirS) in ANAMMOX bacteria through bioengineering means, nirS gene was cloned using the plasmid vector pGEM-T. A target band of 440 bp PCR products from the recombinant genetic engineering bacter was observed by agarose gel electrophoresis. The nirS recombinant genetic engineering bacteria reached stationary phase after 7-8 hours incubation, the addition of nitrogen source was advantageous to the growth of bacteria significantly. The performance of nirS recombinant genetic engineering bacteria was tested by adding different dosages of bacteria and treating sodium nitrite solu‐tion with different initial concentrations. The results showed that, when 30 mL of nirS recombinant genetic engi‐neering bacteria(2.3 × 107 cells/mL) inoculates was added to the solution with 40 mg/L of initial mass concentra‐tion of nitrite, the removal rate of nitrite reached above 90%. It was indicated that nirS recombinant genetic en‐gineering bacteria could be applied for nitrite-containing wastewater treatment in the future.

  9. Highly sensitive NIR PtSi/Si-nanostructure detectors

    Science.gov (United States)

    Li, Hua-gao; Guo, Pei; Yuan, An-bo; Long, Fei; Li, Rui-zhi; Li, Ping; Li, Yi

    2016-10-01

    We report a high external quantum efficiency (EQE) photodiode detector with PtSi/Si-nanostructures. Black silicon nanostructures were fabricated by metal-assist chemical etching (MCE), a 2 nm Pt layer was subsequently deposited on black silicon surface by DC magnetron sputtering system, and PtSi/Si-nanostructures were formed in vacuum annealing at 450 oC for 5 min. As the PtSi/Si-nanostructures presented a spiky shape, the absorption of incident light was remarkably enhanced for the repeat reflection and absorption. The breakdown voltage, dark current, threshold voltage and responsivity of the device were investigated to evaluate the performance of the PtSi/Si-nanostructures detector. The threshold voltage and dark currents of the PtSi/Si-nanostructure photodiode tends to be slightly higher than those of the standard diodes. The breakdown voltage remarkably was reduced because of existing avalanche breakdown in PtSi/Si-nanostructures. However, the photodiodes had high response at room temperature in near infrared region. At -5 V reverse bias voltage, the responsivity was 0.72 A/W in 1064 nm wavelength, and the EQE was 83.9%. By increasing the reverse bias voltage, the responsivity increased. At -60 V reverse bias voltage, the responsivity was 3.5 A/W, and the EQE was 407.5%, which means the quantum efficiency of PtSi/Si-nanostructure photodiodes was about 10 times higher than that of a standard diode. Future research includes how to apply this technology to enhance the NIR sensitivity of image sensors, such as Charge Coupled Devices (CCD).

  10. SHARK-NIR: from K-band to a key instrument, a status update

    Science.gov (United States)

    Farinato, Jacopo; Bacciotti, Francesca; Baffa, Carlo; Baruffolo, Andrea; Bergomi, Maria; Bongiorno, Angela; Carbonaro, Luca; Carolo, Elena; Carlotti, Alexis; Centrone, Mauro; Close, Laird; De Pascale, Marco; Dima, Marco; D'Orazi, Valentina; Esposito, Simone; Fantinel, Daniela; Farisato, Giancarlo; Gaessler, Wolfgang; Giallongo, Emanuele; Greggio, Davide; Guyon, Olivier; Hinz, Philip; Lisi, Franco; Magrin, Demetrio; Marafatto, Luca; Mohr, Lars; Montoya, Manny; Pedichini, Fernando; Pinna, Enrico; Puglisi, Alfio; Ragazzoni, Roberto; Salasnich, Bernardo; Stangalini, Marco; Vassallo, Daniele; Verinaud, Christophe; Viotto, Valentina

    2016-07-01

    SHARK-NIR channel is one of the two coronagraphic instruments proposed for the Large Binocular Telescope, in the framework of the call for second generation instruments, issued in 2014. Together with the SHARK-VIS channel, it will offer a few observing modes (direct imaging, coronagraphic imaging and coronagraphic low resolution spectroscopy) covering a wide wavelength domain, going from 0.5μm to 1.7μm. Initially proposed as an instrument covering also the K-band, the current design foresees a camera working from Y to H bands, exploiting in this way the synergy with other LBT instruments such as LBTI, which is actually covering wavelengths greater than L' band, and it will be soon upgraded to work also in K band. SHARK-NIR has been undergoing the conceptual design review at the end of 2015 and it has been approved to proceed to the final design phase, receiving the green light for successive construction and installation at LBT. The current design is significantly more flexible than the previous one, having an additional intermediate pupil plane that will allow the usage of coronagraphic techniques very efficient in term of contrast and vicinity to the star, increasing the instrument coronagraphic performance. The latter is necessary to properly exploit the search of giant exo-planets, which is the main science case and the driver for the technical choices of SHARK-NIR. We also emphasize that the LBT AO SOUL upgrade will further improve the AO performance, making possible to extend the exo-planet search to target fainter than normally achieved by other 8-m class telescopes, and opening in this way to other very interesting scientific scenarios, such as the characterization of AGN and Quasars (normally too faint to be observed) and increasing considerably the sample of disks and jets to be studied. Finally, we emphasize that SHARK-NIR will offer XAO direct imaging capability on a FoV of about 15"x15", and a simple coronagraphic spectroscopic mode offering spectral

  11. Implementation of a 4x8 NIR and CCD Mosaic Focal Plane Technology

    Science.gov (United States)

    Jelinsky, Patrick; Bebek, C. J.; Besuner, R. W.; Haller, G. M.; Harris, S. E.; Hart, P. A.; Heetderks, H. D.; Levi, M. E.; Maldonado, S. E.; Roe, N. A.; Roodman, A. J.; Sapozhnikov, L.

    2011-01-01

    Mission concepts for NASA's Wide Field Infrared Survey Telescope (WFIRST), ESA's EUCLID mission, as well as for ground based observations, have requirements for large mosaic focal planes to image visible and near infrared (NIR) wavelengths. We have developed detectors, readout electronics and focal plane design techniques that can be used to create very large scalable focal plane mosaic cameras. In our technology, CCDs and HgCdTe detectors can be intermingled on a single, silicon carbide (SiC) cold plate. This enables optimized, wideband observing strategies. The CCDs, developed at Lawrence Berkeley National Laboratory, are fully-depleted, p-channel devices that are backside illuminated capable of operating at temperatures as low as 110K and have been optimized for the weak lensing dark energy technique. The NIR detectors are 1.7µm and 2.0µm wavelength cutoff H2RG® HgCdTe, manufactured by Teledyne Imaging Sensors under contract to LBL. Both the CCDs and NIR detectors are packaged on 4-side abuttable SiC pedestals with a common mounting footprint supporting a 44.16mm mosaic pitch and are coplanar. Both types of detectors have direct-attached, readout electronics that convert the detector signal directly to serial, digital data streams and allow a flexible, low cost data acquisition strategy, despite the large data volume. A mosaic of these detectors can be operated at a common temperature that achieves the required dark current and read noise performance in both types of detectors necessary for dark energy observations. We report here the design and integration for a focal plane designed to accommodate a 4x8 heterogeneous array of CCDs and HgCdTe detectors. Our current implementation contains over 1/4-billion pixels.

  12. NIRS monitoring of muscle contraction to control a prosthetic device

    Science.gov (United States)

    Bianchi, Thomas; Zambarbieri, Daniela; Beltrami, Giorgio; Verni, Gennaro

    1999-01-01

    The fitting of upper-extremity amputees requires special efforts, and its significance has been increased by the development of the myoelectrically controlled prosthetic arm. This solution is not free of problems due to the nature of the amputation, to the electromagnetic noise affecting the myelectrical signal and to the perspiration due to the contact between socket and the residual limb. Starting from the fact that NIRS and electromyographic signals are similar during a muscle contraction, we have first studied the NIRS signal during forearm muscle contractions in normal and amputee subjects. Then a new system to interface the NIRS unit and the myoelectrical prosthetic hand has been developed. The NIRS unit has been used as optical sensor and all the operations (I/O and signal processing) are performed via software. This system has been tested on normal and amputee subjects performing hand grasping using a visual biofeedback control scheme. All the subjects have been able to perform these operations demonstrating the NIRS technique. This could represent an alternative solution for controlling a prosthetic device.

  13. Estimation of Anthocyanin Content of Berries by NIR Method

    Science.gov (United States)

    Zsivanovits, G.; Ludneva, D.; Iliev, A.

    2010-01-01

    Anthocyanin contents of fruits were estimated by VIS spectrophotometer and compared with spectra measured by NIR spectrophotometer (600-1100 nm step 10 nm). The aim was to find a relationship between NIR method and traditional spectrophotometric method. The testing protocol, using NIR, is easier, faster and non-destructive. NIR spectra were prepared in pairs, reflectance and transmittance. A modular spectrocomputer, realized on the basis of a monochromator and peripherals Bentham Instruments Ltd (GB) and a photometric camera created at Canning Research Institute, were used. An important feature of this camera is the possibility offered for a simultaneous measurement of both transmittance and reflectance with geometry patterns T0/180 and R0/45. The collected spectra were analyzed by CAMO Unscrambler 9.1 software, with PCA, PLS, PCR methods. Based on the analyzed spectra quality and quantity sensitive calibrations were prepared. The results showed that the NIR method allows measuring of the total anthocyanin content in fresh berry fruits or processed products without destroying them.

  14. Activation detection in fNIRS by wavelet coherence

    Science.gov (United States)

    Zhang, Xin; Niu, Haijing; Song, Yan; Fan, Yong

    2012-03-01

    Functional near infrared spectroscopy (fNIRS) is an optical technique measuring hemoglobin oxygenation and deoxygenation concentrations of the brain cortex with higher temporal resolution than current alternative techniques. The high temporal resolution enables collecting abundant brain functional information. However, the information collected by fNIRS is correlated and mixed with a variety of physiological signals. Due to the mixture effect, activation detection is one of challenges in fNIRS based studies of the brain functional activities. To achieve a better detection of activated brain regions from the complicated information measures, we present a multi-scale analysis method based on a wavelet coherence measure. In particular, the paradigm of an experiment is used as the reference signal. The coherence of the signal with data measured by fNIRS at each channel is calculated and summed up to evaluate the activation level. Experiments on simulated and real data have demonstrated that the proposed method is efficient and effective to detect activated brain regions covered by the fNIRS probe.

  15. High temperature thermal stability investigations of ammonium sulphide passivated InGaAs and interface formation with Al{sub 2}O{sub 3} studied by synchrotron radiation based photoemission

    Energy Technology Data Exchange (ETDEWEB)

    Chauhan, Lalit, E-mail: lalit.chauhan2@mail.dcu.ie [School of Physical Sciences, Dublin City University, Glasnevin, Dublin 9 (Ireland); Gajula, Durga Rao; McNeill, David [School of Electronics, Electrical Engineering and Computer Science, Queen' s University Belfast (United Kingdom); Hughes, Greg [School of Physical Sciences, Dublin City University, Glasnevin, Dublin 9 (Ireland)

    2014-10-30

    Highlights: • Sulphur passivation is effective at removing the native oxides from InGaAs surface. • A 700°C anneal of the sulphur passivated surface at leads to the loss of indium. • A 1 nm Al2O3 layer improves the thermal stability of the sulphur passivated InGaAs. - Abstract: High resolution synchrotron radiation core level photoemission measurements have been used to undertake a comparative study of the high temperature thermal stability of the ammonium sulphide passivated InGaAs surface and the same surface following the atomic layer deposition (ALD) of an ultrathin (∼1 nm) Al{sub 2}O{sub 3} layer. The solution based ex situ sulphur passivation was found to be effective at removing a significant amount of the native oxides and protecting the surface against re-oxidation upon air exposure. The residual interfacial oxides which form between sulphur passivated InGaAs and the ultrathin Al{sub 2}O{sub 3} layer can be substantially removed at high temperature (up to 700°C) without impacting on the InGaAs stoichiometry while significant loss of indium was recorded at this temperature on the uncovered sulphur passivated InGaAs surface.

  16. Fast Discrimination of Bamboo Species Using VIS/NIR Spectroscopy

    Science.gov (United States)

    Wang, Y. Z.; Dong, W. Y.; Kouba, A. J.

    2016-11-01

    The potential of visible/near-infrared (Vis/NIR) spectroscopy to discriminate different bamboo species was investigated. Vis/NIR spectra were collected on three bamboo species, Bashania fargesii, Fargesia qinlingensis, and Phyllostachys glauca, in the wavelength range of 350-2500 nm. The range of 425-2400 nm was chosen for the spectra modeling. Multiplicative signal correction, standard normal variate with detrending, and 1st and 2nd derivatives were used to preprocess the raw spectral data, and the results were compared. Soft independent modeling of class analogy (SIMCA) and partial least squares discriminant analysis (PLS-DA) methods were applied for building discriminant models. The recognition ratio of 30 samples in the validation set was 100% by both SIMCA and PLSDA models. These results indicate that Vis/NIR spectroscopy may provide a fast and nondestructive technique to discriminate different bamboo species in the field.

  17. NIRS - Near infrared spectroscopy - investigations in neurovascular diseases

    DEFF Research Database (Denmark)

    Schytz, Henrik Winther

    2015-01-01

    in cerebral blood flow (CBF), the first study investigated a multi-source detector separation configuration and indocyanine green (ICG) as a tracer to calculate a corrected blood flow index (BFI) value. The study showed no correlation between CBF changes measured by 133Xenon single photon emission computer......The purpose of this thesis was to explore and develop methods, where continuous wave near infrared spectroscopy (CW-NIRS) can be applied in different neurovascular diseases, in order to find biological markers that are useful in clinical neurology. To develop a new method to detect changes...... tomography (133Xe-SPECT) and the corrected BFI value. It was concluded, that it was not possible to obtain reliable BFI data with the ICG CW-NIRS method. NIRS measurements of low frequency oscillations (LFOs) may be a reliable method to investigate vascular alterations in neurovascular diseases...

  18. NIR triggered observations of Sgr A* at 43 GHz

    Science.gov (United States)

    Rauch, C.; Ros, E.; Krichbaum, T. P.; Eckart, A.; Zensus, J. A.; Lu, R.-S.; Shahzamanian, B.; Mužić, K.; Peißker, F.

    2017-01-01

    The compact radio and near-infrared (NIR) source Sagittarius A* has been observed in the context of two NIR triggered global VLT and VLBA campaigns at 43 GHz (7 mm) on May 16-18 2012 and October 4 2014. While on October 4 2014 Sgr A* remained in a quiescent state, a NIR flare on May 17 2012 is accompanied by an increase in flux density of 0.22 Jy at 7 mm delayed by 4.5+/-0.5 h. Additionally, Sgr A* seems to develop a weak secondary radio off-core component of 0.02 Jy at a position angle of 140° and an angular distance of 1.5 mas shortly before the peak of the flare. This spatial extension and the time delay are in the range of expected values for events casually connected by adiabatic expansion.

  19. Hardersen IRTF Asteroid NIR Reflectance Spectra V1.0

    Science.gov (United States)

    Hardersen, P. S.

    2016-06-01

    This dataset includes average near-infrared (NIR) reflectance spectra for 68 main-belt asteroids that were observed at the NASA Infrared Telescope Facility (IRTF), Mauna Kea, Hawaii, from April 2001 to January 2015. Raw NIR spectral data were obtained under mostly uniform instrumental conditions and include observations of the asteroids, extinction stars, and solar analog stars that were necessary for data reduction and production of the final average asteroid NIR reflectance spectra. SpecPR and Spextool were used during data reduction to produce the final spectra and both programs utilize similar functions that include sky background subtraction, telluric corrections, channel shifting, and averaging routines. The set of asteroids observed include a wide variety of taxonomic types and include V-, S-, M-, X-types that correspond to a wide variety of surface mineralogies, rock types, and potential meteorite analogs.

  20. Emerging Multifunctional NIR Photothermal Therapy Systems Based on Polypyrrole Nanoparticles

    Directory of Open Access Journals (Sweden)

    Mozhen Wang

    2016-10-01

    Full Text Available Near-infrared (NIR-light-triggered therapy platforms are now considered as a new and exciting possibility for clinical nanomedicine applications. As a promising photothermal agent, polypyrrole (PPy nanoparticles have been extensively studied for the hyperthermia in cancer therapy due to their strong NIR light photothermal effect and excellent biocompatibility. However, the photothermal application of PPy based nanomaterials is still in its preliminary stage. Developing PPy based multifunctional nanomaterials for cancer treatment in vivo should be the future trend and object for cancer therapy. In this review, the synthesis of PPy nanoparticles and their NIR photothermal conversion performance were first discussed, followed by a summary of the recent progress in the design and implementation on the mulitifunctionalization of PPy or PPy based therapeutic platforms, as well as the introduction of their exciting biomedical applications based on the synergy between the photothermal conversion effect and other stimulative responsibilities.

  1. Exploiting neurovascular coupling: a Bayesian sequential Monte Carlo approach applied to simulated EEG fNIRS data

    Science.gov (United States)

    Croce, Pierpaolo; Zappasodi, Filippo; Merla, Arcangelo; Chiarelli, Antonio Maria

    2017-08-01

    Objective. Electrical and hemodynamic brain activity are linked through the neurovascular coupling process and they can be simultaneously measured through integration of electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS). Thanks to the lack of electro-optical interference, the two procedures can be easily combined and, whereas EEG provides electrophysiological information, fNIRS can provide measurements of two hemodynamic variables, such as oxygenated and deoxygenated hemoglobin. A Bayesian sequential Monte Carlo approach (particle filter, PF) was applied to simulated recordings of electrical and neurovascular mediated hemodynamic activity, and the advantages of a unified framework were shown. Approach. Multiple neural activities and hemodynamic responses were simulated in the primary motor cortex of a subject brain. EEG and fNIRS recordings were obtained by means of forward models of volume conduction and light propagation through the head. A state space model of combined EEG and fNIRS data was built and its dynamic evolution was estimated through a Bayesian sequential Monte Carlo approach (PF). Main results. We showed the feasibility of the procedure and the improvements in both electrical and hemodynamic brain activity reconstruction when using the PF on combined EEG and fNIRS measurements. Significance. The investigated procedure allows one to combine the information provided by the two methodologies, and, by taking advantage of a physical model of the coupling between electrical and hemodynamic response, to obtain a better estimate of brain activity evolution. Despite the high computational demand, application of such an approach to in vivo recordings could fully exploit the advantages of this combined brain imaging technology.

  2. A Gaussian mixture model based adaptive classifier for fNIRS brain-computer interfaces and its testing via simulation

    Science.gov (United States)

    Li, Zheng; Jiang, Yi-han; Duan, Lian; Zhu, Chao-zhe

    2017-08-01

    Objective. Functional near infra-red spectroscopy (fNIRS) is a promising brain imaging technology for brain-computer interfaces (BCI). Future clinical uses of fNIRS will likely require operation over long time spans, during which neural activation patterns may change. However, current decoders for fNIRS signals are not designed to handle changing activation patterns. The objective of this study is to test via simulations a new adaptive decoder for fNIRS signals, the Gaussian mixture model adaptive classifier (GMMAC). Approach. GMMAC can simultaneously classify and track activation pattern changes without the need for ground-truth labels. This adaptive classifier uses computationally efficient variational Bayesian inference to label new data points and update mixture model parameters, using the previous model parameters as priors. We test GMMAC in simulations in which neural activation patterns change over time and compare to static decoders and unsupervised adaptive linear discriminant analysis classifiers. Main results. Our simulation experiments show GMMAC can accurately decode under time-varying activation patterns: shifts of activation region, expansions of activation region, and combined contractions and shifts of activation region. Furthermore, the experiments show the proposed method can track the changing shape of the activation region. Compared to prior work, GMMAC performed significantly better than the other unsupervised adaptive classifiers on a difficult activation pattern change simulation: 99% versus  <54% in two-choice classification accuracy. Significance. We believe GMMAC will be useful for clinical fNIRS-based brain-computer interfaces, including neurofeedback training systems, where operation over long time spans is required.

  3. fNIRS-based brain-computer interfaces: a review.

    Science.gov (United States)

    Naseer, Noman; Hong, Keum-Shik

    2015-01-01

    A brain-computer interface (BCI) is a communication system that allows the use of brain activity to control computers or other external devices. It can, by bypassing the peripheral nervous system, provide a means of communication for people suffering from severe motor disabilities or in a persistent vegetative state. In this paper, brain-signal generation tasks, noise removal methods, feature extraction/selection schemes, and classification techniques for fNIRS-based BCI are reviewed. The most common brain areas for fNIRS BCI are the primary motor cortex and the prefrontal cortex. In relation to the motor cortex, motor imagery tasks were preferred to motor execution tasks since possible proprioceptive feedback could be avoided. In relation to the prefrontal cortex, fNIRS showed a significant advantage due to no hair in detecting the cognitive tasks like mental arithmetic, music imagery, emotion induction, etc. In removing physiological noise in fNIRS data, band-pass filtering was mostly used. However, more advanced techniques like adaptive filtering, independent component analysis (ICA), multi optodes arrangement, etc. are being pursued to overcome the problem that a band-pass filter cannot be used when both brain and physiological signals occur within a close band. In extracting features related to the desired brain signal, the mean, variance, peak value, slope, skewness, and kurtosis of the noised-removed hemodynamic response were used. For classification, the linear discriminant analysis method provided simple but good performance among others: support vector machine (SVM), hidden Markov model (HMM), artificial neural network, etc. fNIRS will be more widely used to monitor the occurrence of neuro-plasticity after neuro-rehabilitation and neuro-stimulation. Technical breakthroughs in the future are expected via bundled-type probes, hybrid EEG-fNIRS BCI, and through the detection of initial dips.

  4. Application of NIR spectroscopy for firmness evaluation of peaches

    Institute of Scientific and Technical Information of China (English)

    Xia-ping FU; Yi-bin YING; Ying ZHOU; Li-juan XIE; Hui-rong XU

    2008-01-01

    The use of near infrared (NIR) spectroscopy was proved to be a useful tool for quality analysis of fruits. A bifurcated fiber type NIR spectrometer, with a detection range of 800~2500 nm by lnGaAs detector, was used to evaluate the firmness of peaches. Anisotropy of NIR spectra and firmness of peaches in relation to detecting positions of different parts (including three latitudes and three longitudes) were investigated. Both spectra absorbency and firmness of peach were influenced by longitudes (i,ii, iii) and latitudes (A, B, C). For modeling, two thirds of the samples were used as the calibration set and the remaining one third were used as the validation or prediction set. Partial least square regression (PLSR) models for different longitude and latitude spectra and for the whole fruit show that collecting several NIR spectra from different longitudes and latitudes of a fruit for NIR calibration modeling can improve the modeling performance. In addition, proper spectra pretreatments like scattering correction or derivative also can enhance the modeling performance. The best results obtained in this study were from the holistic model with multiplicative scattering correction (MSC) pretreatment, with correlation coefficient of cross-validation rcv=0.864, root mean square error of cross-validation RMSECV=6.71 N, correlation coefficient of calibration r=0.948, root mean square error of cali-bration RMSEC=4.21 N and root mean square error of prediction RMSEP=5.42 N. The results of this study are useful for further research and application that when applying NIR spectroscopy for objectives with anisotropic differences, spectra and quality indices are necessarily measured from several parts of each object to improve the modeling performance.

  5. fNIRS-based brain-computer interfaces: a review

    Directory of Open Access Journals (Sweden)

    Noman eNaseer

    2015-01-01

    Full Text Available A brain-computer interface (BCI is a communication system that allows the use of brain activity to control computers or other external devices. It can, by bypassing the peripheral nervous system, provide a means of communication for people suffering from severe motor disabilities or in a persistent vegetative state. In this paper, brain-signal generation tasks, noise removal methods, feature extraction/selection schemes, and classification techniques for fNIRS-based BCI are reviewed. The most common brain areas for fNIRS BCI are the primary motor cortex and the prefrontal cortex. In relation to the motor cortex, motor imagery tasks were preferred to motor execution tasks since possible proprioceptive feedback could be avoided. In relation to the prefrontal cortex, fNIRS showed a significant advantage due to no hair in detecting the cognitive tasks like mental arithmetic, music imagery, emotion induction, etc. In removing physiological noise in fNIRS data, band-pass filtering was mostly used. However, more advanced techniques like adaptive filtering, independent component analysis, multi optodes arrangement, etc. are being pursued to overcome the problem that a band-pass filter cannot be used when both brain and physiological signals occur within a close band. In extracting features related to the desired brain signal, the mean, variance, peak value, slope, skewness, and kurtosis of the noised-removed hemodynamic response were used. For classification, the linear discriminant analysis method provided simple but good performance among others: support vector machine, hidden Markov model, artificial neural network, etc. fNIRS will be more widely used to monitor the occurrence of neuro-plasticity after neuro-rehabilitation and neuro-stimulation. Technical breakthroughs in the future are expected via bundled-type probes, hybrid EEG-fNIRS BCI, and through the detection of initial dips.

  6. An exploratory fNIRS study with immersive virtual reality: a new method for technical implementation.

    Science.gov (United States)

    Seraglia, Bruno; Gamberini, Luciano; Priftis, Konstantinos; Scatturin, Pietro; Martinelli, Massimiliano; Cutini, Simone

    2011-01-01

    For over two decades Virtual Reality (VR) has been used as a useful tool in several fields, from medical and psychological treatments, to industrial and military applications. Only in recent years researchers have begun to study the neural correlates that subtend VR experiences. Even if the functional Magnetic Resonance Imaging (fMRI) is the most common and used technique, it suffers several limitations and problems. Here we present a methodology that involves the use of a new and growing brain imaging technique, functional Near-infrared Spectroscopy (fNIRS), while participants experience immersive VR. In order to allow a proper fNIRS probe application, a custom-made VR helmet was created. To test the adapted helmet, a virtual version of the line bisection task was used. Participants could bisect the lines in a virtual peripersonal or extrapersonal space, through the manipulation of a Nintendo Wiimote ® controller in order for the participants to move a virtual laser pointer. Although no neural correlates of the dissociation between peripersonal and extrapersonal space were found, a significant hemodynamic activity with respect to the baseline was present in the right parietal and occipital areas. Both advantages and disadvantages of the presented methodology are discussed.

  7. NIR-to-visible upconversion nanoparticles for fluorescent labeling and targeted delivery of siRNA

    Science.gov (United States)

    Jiang, Shan; Zhang, Yong; Lim, Kian Meng; Sim, Eugene K. W.; Ye, Lei

    2009-04-01

    Near-infrared (NIR)-to-visible upconversion fluorescent nanoparticles were synthesized and used for imaging and targeted delivery of small interfering RNA (siRNA) to cancer cells. Silica-coated NaYF4 upconversion nanoparticles (UCNs) co-doped with lanthanide ions (Yb/Er) were synthesized. Folic acid and anti-Her2 antibody conjugated UCNs were used to fluorescently label the folate receptors of HT-29 cells and Her2 receptors of SK-BR-3 cells, respectively. The intracellular uptake of the folic acid and antibody conjugated UCNs was visualized using a confocal fluorescence microscope equipped with an NIR laser. siRNA was attached to anti-Her2 antibody conjugated UCNs and the delivery of these nanoparticles to SK-BR-3 cells was studied. Meanwhile, a luciferase assay was established to confirm the gene silencing effect of siRNA. Upconversion nanoparticles can serve as a fluorescent probe and delivery system for simultaneous imaging and delivery of biological molecules.

  8. NIR-to-visible upconversion nanoparticles for fluorescent labeling and targeted delivery of siRNA

    Energy Technology Data Exchange (ETDEWEB)

    Jiang Shan; Zhang Yong [Division of Bioengineering, Faculty of Engineering, National University of Singapore, 117576 (Singapore); Lim, Kian Meng [Department of Mechanical Engineering, National University of Singapore, 119260 (Singapore); Sim, Eugene K W [Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 117597 (Singapore); Ye Lei [National University Medical Institutes, National University of Singapore, 117597 (Singapore)], E-mail: biezy@nus.edu.sg

    2009-04-15

    Near-infrared (NIR)-to-visible upconversion fluorescent nanoparticles were synthesized and used for imaging and targeted delivery of small interfering RNA (siRNA) to cancer cells. Silica-coated NaYF{sub 4} upconversion nanoparticles (UCNs) co-doped with lanthanide ions (Yb/Er) were synthesized. Folic acid and anti-Her2 antibody conjugated UCNs were used to fluorescently label the folate receptors of HT-29 cells and Her2 receptors of SK-BR-3 cells, respectively. The intracellular uptake of the folic acid and antibody conjugated UCNs was visualized using a confocal fluorescence microscope equipped with an NIR laser. siRNA was attached to anti-Her2 antibody conjugated UCNs and the delivery of these nanoparticles to SK-BR-3 cells was studied. Meanwhile, a luciferase assay was established to confirm the gene silencing effect of siRNA. Upconversion nanoparticles can serve as a fluorescent probe and delivery system for simultaneous imaging and delivery of biological molecules.

  9. Overview of the Near-IR S0 galaxy Survey (NIRS0S)

    CERN Document Server

    Laurikainen, E; Buta, R; Knapen, J H

    2011-01-01

    A review of the results of the Near-IR S0 galaxy Survey (NIRS0S) is presented. NIRS0S is a magnitude (mB 12.5 mag) and inclination (< 65o) limited sample of 200 nearby galaxies, mainly S0s. It uses deep Ks -band images, typically reaching a surface brightness of 23.5 mag arcsec^(-2) . Detailed visual and photometric classifications were made, for the first time coding also the lenses in a systematic manner. As a comparison sample, a similar sized spiral galaxy sample with similar image quality was used. The main emphasis were to study whether the S0s are former spirals in which star formation has been ceased, and also, how robust are bars in galaxies. Based on our analysis the Hubble sequence was revisited: following the early idea by van den Bergh we suggested that the S0s are spread throughout the Hubble sequence in parallel tuning forks as spirals (S0a, S0b, S0c etc.). This is evidenced by our improved bulge-to-total (B/T) flux ratios, reaching as small values as typically found in late-type spirals. Th...

  10. An Exploratory fNIRS Study with Immersive Virtual Reality: A New Method for Technical Implementation

    Directory of Open Access Journals (Sweden)

    Bruno eSeraglia

    2011-12-01

    Full Text Available For over two decades Virtual Reality has been used as a useful tool in several fields, from medical and psychological treatments, to industrial and military applications. Only in recent years researchers have begun to study the neural correlates that subtend virtual reality experiences. Even if the fMRI brain image technique is the most common and used technique, it suffers several limitations and problems. Here we present a methodology that involves the use of a new and growing brain imaging technique, fNIRS functional Near-infrared Spectroscopy, while participants experience immersive virtual reality. In order to allow a proper fNIRS probe application, a custom-made virtual reality helmet was created. To test the adapted helmet, a virtual version of the line bisection task was used. Participants could bisect the lines in a virtual peripersonal or extrapersonal space, through the manipulation of a Wiimote controller in order for the participants to move a virtual laser pointer. Although no neural correlates of the dissociation between peripersonal and extrapersonal space were found, a significant hemodynamic activity with respect to the baseline was present in the right parietal and occipital areas. Both advantages and disadvantages of the presented methodology are discussed.

  11. Terahertz-frequency photoconductive detectors fabricated from metal-organic chemical vapor deposition-grown Fe-doped InGaAs

    Science.gov (United States)

    Hatem, O.; Cunningham, J.; Linfield, E. H.; Wood, C. D.; Davies, A. G.; Cannard, P. J.; Robertson, M. J.; Moodie, D. G.

    2011-03-01

    We report the detection of terahertz frequency radiation using photoconductive antennas fabricated from Fe-doped InGaAs, grown by metal-organic chemical vapor deposition. Coherent photoconductive detection is demonstrated using femtosecond laser pulses centered at either an 800 or a 1550 nm wavelength. The InGaAs resistivity and the sensitivity of photoconductive detection are both found to depend on the Fe-doping level. We investigate a wide range of probe laser powers, finding a peak in detected signal for ˜5 mW probe power, followed by a reduction at larger powers, attributed to screening of the detected THz field by photo-generated carriers in the material. The measured signal from Fe:InGaAs photoconductive detectors excited at 800 nm is four times greater than that from a low-temperature-grown GaAs photodetector with identical antenna design, despite the use of a ten times smaller probe power.

  12. Influence of interface traps inside the conduction band on the capacitance–voltage characteristics of InGaAs metal–oxide–semiconductor capacitors

    Science.gov (United States)

    Taoka, Noriyuki; Yokoyama, Masafumi; Kim, Sang Hyeon; Suzuki, Rena; Iida, Ryo; Takenaka, Mitsuru; Takagi, Shinichi

    2016-11-01

    We investigated the influences of the AC response with interface/bulk-oxide traps near the conduction band (CB) and a low effective density of states (DOS) on the accumulation capacitance C acc of an n-type InGaAs metal–oxide–semiconductor (MOS) capacitor. We found that the capacitance associated with the interface traps inside the CB significantly increases C acc compared to the C acc value constrained by a low DOS. These results indicate that accurate characterization inside the CB and considering the capacitance due to the interface traps inside the CB in the MOS capacitance–voltage curves are indispensable for accurate characterization of InGaAs MOS interface properties.

  13. Comparative optical study of epitaxial InGaAs quantum rods grown with As{sub 2} and As{sub 4} sources

    Energy Technology Data Exchange (ETDEWEB)

    Nedzinskas, Ramūnas; Čechavičius, Bronislovas; Kavaliauskas, Julius; Karpus, Vytautas; Valušis, Gintaras [Semiconductor Physics Institute, Center for Physical Sciences and Technology, A. Goštauto 11, LT-01108 Vilnius (Lithuania); Li, Lianhe; Khanna, Suraj P.; Linfield, Edmund H. [School of Electronic and Electrical Engineering, University of Leeds, Leeds LS2 9JT (United Kingdom)

    2013-12-04

    Photoreflectance and photoluminescence (PL) spectroscopies are used to examine the optical properties and electronic structure of InGaAs quantum rods (QRs), embedded within InGaAs quantum well (QW). The nanostructures studied were grown by molecular beam epitaxy using As{sub 2} or As{sub 4} sources. The impact of As source on spectral features associated with interband optical transitions in the QRs and the surrounding QW are demonstrated. A red shift of the QR- and a blue shift of the QW-related optical transitions, along with a significant increase in PL intensity, have been observed if an As{sub 4} source is used. The changes in optical properties are attributed mainly to carrier confinement effects caused by variation of In content contrast between the QR material and the surrounding well.

  14. Growth and properties of In(Ga)As nanowires on silicon

    Energy Technology Data Exchange (ETDEWEB)

    Hertenberger, Simon

    2012-10-15

    nanowire properties and homogeneous array-like characteristics. High vertical growth yields of 90 % are achieved on substrates patterned either by e-beam lithography (for small scale arrays) or nanoimprint lithography (NIL, for large scale arrays > 5 x 5 mm{sup 2}). In addition, X-ray rocking curve measurements evidence very low crystal tilt and perfect vertical alignment along the (111) direction with full widths at half maximum (FWHM) as low as 0.6 . Furthermore, systematic investigations of the size scaling behavior as a function of the pitch (interwire distance) highlight the existence of two growth regimes: (i) a competitive growth regime for narrow pitches and (ii) a diffusion-limited regime for wider pitches, where growth is limited by the diffusion length of In adatoms on the SiO{sub 2} surface (∝750 nm at T=480 C). Furthermore, the growth of ternary InGaAs nanowires on sputter-deposited SiO{sub x}/Si(111) and NIL-patterned SiO{sub 2}/Si(111) substrates is investigated. Here, composition tuning with Ga contents ranging from 0-60 % was achieved as confirmed by X-ray diffraction and energy dispersive X-ray spectroscopy. Furthermore, the two different growth strategies are compared yielding a significantly lower FWHM of the 2θ-XRD-peak in the case of NIL-patterned substrates (0.031 ) as compared to self-assembled grown nanowires (0.084 ). This finding is further supported by Raman spectroscopy showing lower longitudinal optical to transversal optical (LO/TO) intensity ratios and lower LO-FWHM for both the InAs-like and GaAs-like LO modes in the case of NIL-patterned nanowire growth. These observations indicate superior composition homogeneity for positioned nanowire growth on patterned substrates. In addition, low-T photoluminescence (PL) measurements are presented showing band gap tuning over a wavelength range of ∝1800-2850 nm where PL peak linewidths are as narrow as ∝30 meV, independent of the Ga content. Finally, the effect of growth parameters on the

  15. Speech-evoked activation in adult temporal cortex measured using functional near-infrared spectroscopy (fNIRS): Are the measurements reliable?

    Science.gov (United States)

    Wiggins, Ian M; Anderson, Carly A; Kitterick, Pádraig T; Hartley, Douglas E H

    2016-09-01

    Functional near-infrared spectroscopy (fNIRS) is a silent, non-invasive neuroimaging technique that is potentially well suited to auditory research. However, the reliability of auditory-evoked activation measured using fNIRS is largely unknown. The present study investigated the test-retest reliability of speech-evoked fNIRS responses in normally-hearing adults. Seventeen participants underwent fNIRS imaging in two sessions separated by three months. In a block design, participants were presented with auditory speech, visual speech (silent speechreading), and audiovisual speech conditions. Optode arrays were placed bilaterally over the temporal lobes, targeting auditory brain regions. A range of established metrics was used to quantify the reproducibility of cortical activation patterns, as well as the amplitude and time course of the haemodynamic response within predefined regions of interest. The use of a signal processing algorithm designed to reduce the influence of systemic physiological signals was found to be crucial to achieving reliable detection of significant activation at the group level. For auditory speech (with or without visual cues), reliability was good to excellent at the group level, but highly variable among individuals. Temporal-lobe activation in response to visual speech was less reliable, especially in the right hemisphere. Consistent with previous reports, fNIRS reliability was improved by averaging across a small number of channels overlying a cortical region of interest. Overall, the present results confirm that fNIRS can measure speech-evoked auditory responses in adults that are highly reliable at the group level, and indicate that signal processing to reduce physiological noise may substantially improve the reliability of fNIRS measurements.

  16. Deep NIR Photometry of HI Galaxies Behind the Milky Way

    CERN Document Server

    Williams, Wendy L; Kraan-Korteweg, Renee C

    2011-01-01

    Current studies of the peculiar velocity flow field in the Local Universe are limited by the lack of detection of galaxies behind the Milky Way. The contribution of the largely unknown mass distribution in this "Zone of Avoidance" (ZoA) to the dynamics of the Local group remains contraversial. We have undertaken a near infrared (NIR) survey of HI detected galaxies in the ZoA. The photomety derived here will be used in the NIR Tully-Fisher (TF) relation to derive the peculiar velocities of this sample of galaxies in the ZoA.

  17. NIR brightening of the Quasar PKS0735+17

    Science.gov (United States)

    Carrasco, L.; Porras, A.; Escobedo, G.; Recillas, E.; Chabushyan, V.; Carraminana, A.; Mayya, D.

    2014-01-01

    We report on the NIR brightening of the intermediate redshift quasar PKS0735+17 (z=0.424), also known as CGRaBSJ04738+1742, associated with the gamma-ray source 2FGL0738.0+1742. Our NIR photometry for this source shows that, on Jan 7th,2014 (JD2456664.848838), the object brightness corresponded to J = 13.39 +/- 0.04, H = 12.582 +/- 0.03 and Ks = 11.826 +/- 0.03. These values are about 0.5 magnitud brighter than our previous photometry, obtained on JD2456306, for this field.

  18. NIR brightening of the Blazar BZBJ1059-1134

    Science.gov (United States)

    Carrasco, L.; Porras, A.; Escobedo, G.; Recillas, E.; Chabushyan, V.; Carraminana, A.; Mayya, D.

    2014-01-01

    We report on the NIR brightening of the blazar BZBJ1059-1134, also known as PKSB1056-113 associated with the gamma-ray source 2FGL1059.3-1132. Our NIR photometry for this source shows that, on Jan 6th,2014 (JD2456663.9615), the object brightness corresponded to J = 13.804 +/- 0.04, H = 13.069 +/- 0.04 and Ks = 12.352 +/- 0.04. These values are about 1.1 magnitud brighter than our previous photometry, obtained on JD2456464.6, for this field.

  19. Metamorphic InGaAs Quantum Well Laser Diodes at 1.5 μm on GaAs Grown by Molecular Beam Epitaxy

    Institute of Scientific and Technical Information of China (English)

    WANG Hai-Li; I. Tang-ring; S. M. Wang; WU Dong-Hai; WU ning-peng; NI Hqiao-Qiao; HUANG She-Song; XIONG Yong-Hua; WANG Peng-Fei; HAN Qin; NIU Zhi-Chuan

    2009-01-01

    We report a 1.5-μm InGaAs/GaAs quantum well laser diode grown by molecular beam epitaxy on InGaAs metamorphic buffers. At 150K, for a 1500×10μm2 ridge waveguide laser, the lasing wavelength is centred at 1.508μm and the threshold current density is 667 A/cm2 under pulsed operation. The pulsed lasers can operate up to 286 K.

  20. Periodic Two-Dimensional GaAs and InGaAs Quantum Rings Grown on GaAs (001) by Droplet Epitaxy.

    Science.gov (United States)

    Tung, Kar Hoo Patrick; Huang, Jian; Danner, Aaron

    2016-06-01

    Growth of ordered GaAs and InGaAs quantum rings (QRs) in a patterned SiO2 nanohole template by molecular beam epitaxy (MBE) using droplet epitaxy (DE) process is demonstrated. DE is an MBE growth technique used to fabricate quantum nanostructures of high crystal quality by supplying group III and group V elements in separate phases. In this work, ordered QRs grown on an ordered nanohole template are compared to self-assembled QRs grown with the same DE technique without the nanohole template. This study allows us to understand and compare the surface kinetics of Ga and InGa droplets when a template is present. It is found that template-grown GaAs QRs form clustered rings which can be attributed to low mobility of Ga droplets resulting in multiple nucleation sites for QR formation when As is supplied. However, the case of template-grown InGaAs QRs only one ring is formed per nanohole; no clustering is observed. The outer QR diameter is a close match to the nanohole template diameter. This can be attributed to more mobile InGa droplets, which coalesce from an Ostwald ripening to form a single large droplet before As is supplied. Thus, well-patterned InGaAs QRs are demonstrated and the kinetics of their growth are better understood which could potentially lead to improvements in the future devices that require the unique properties of patterned QRs.

  1. Control of interface between HfO{sub 2} and air-exposed InGaAs by ultrathin Si interface control layer

    Energy Technology Data Exchange (ETDEWEB)

    Akazawa, Masamichi; Hasegawa, H. [Research Center for Integrated Quantum Electronics and Graduate School of Information Science and Technology, Hokkaido University, N-13, W-8, Sapporo 060-8628 (Japan)

    2010-02-15

    This paper attempts to control the interface between the air-exposed InGaAs wafer and a high-k dielectric by the Si interface control layer (ICL) technique. As the high-k insulator, HfO{sub 2} film was formed by atomic layer deposition (ALD). Prior to a molecular beam epitaxy (MBE) growth of the Si ICL, efforts were made to minimize native oxide components from the InGaAs surface by various wet surface treatment. After the growth of the Si ICL, an ultrathin SiN{sub x} layer was formed by in-situ partial nitridation of the Si ICL to prevent a subcutaneous oxidation during the sample transfer in air to the ALD chamber. Surface/interface properties were characterized by in-situ X-ray photoelectron spectroscopy (XPS) at each step of interface formation. By using HF-based cleaning, interface bonding configurations similar to those obtained by in-situ UHV process was realized with no trace of native oxide components. As compared with the ALD HfO{sub 2}/InGaAs metal-insulator-semiconductor (MIS) structure which showed existence of strong Fermi level pinning, insertion of the Si ICL achieved large reduction of interface state density, D{sub it}, giving a minimum value of 2x10{sup 11} eV{sup -1}cm{sup -2}. (copyright 2010 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  2. Comparison of different grading schemes in InGaAs metamorphic buffers on GaAs substrate: Tilt dependence on cross-hatch irregularities

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Rahul, E-mail: rkp203@gmail.com [Advanced Technology Development Centre, Indian Institute of Technology, Kharagpur 721302 (India); Bag, Ankush [Advanced Technology Development Centre, Indian Institute of Technology, Kharagpur 721302 (India); Mukhopadhyay, Partha [Rajendra Mishra School of Engineering Entrepreneurship, Indian Institute of Technology, Kharagpur 721302 (India); Das, Subhashis [Advanced Technology Development Centre, Indian Institute of Technology, Kharagpur 721302 (India); Biswas, Dhrubes [Department of Electronics & Electrical Communication Engineering, Indian Institute of Technology, Kharagpur 721 302 (India)

    2015-12-01

    Highlights: • InGaAs graded MBs with different grading scheme has been grown by MBE on GaAs. • Continuously graded MB exhibits smoother surface morphology. • Grading scheme has been found to have little impact on lattice relaxation. • Grading schemeaffects the lattice tilt significantly. • Cross-hatch surface irregularities affect the crystallographic tilt. - Abstract: InGaAs graded metamorphic buffers (MBs) with different grading strategies have been grown by molecular beam epitaxy (MBE) on GaAs (0 0 1) substrate. A detailed comparative analysis of surface using atomic force microscopy (AFM), and bulk properties using high resolution X-ray diffraction (HRXRD) and room temperature photoluminescence (RTPL) of grown MBs have been presented to comprehend the effectiveness of different grading scheme on InGaAs MBs. Conventional, statistical and fractal analysis on measured AFM data has been performed for in-depth investigation of these surfaces. The grading scheme has been found to have little impact on residual strain while it affects the epitaxial tilt significantly. Moreover, the tilt has been found to depend on growth front irregularities. Tilt magnitude in a graded MB has been found to vary with composition while tilt azimuth has been found to be almost same in the graded layers. PL Intensity and a shift in the PL peaks have been used to study the quality of the MB and residual strain comparatively.

  3. Energy levels of InAs/InP QD system with GaAs and InGaAs insertion layers by C-V and DLTS methods

    Energy Technology Data Exchange (ETDEWEB)

    Kim, J. S.; Kim, E. K. [Hanyang University, Seoul (Korea, Republic of); Park, K.; Yoon, E. [Seoul National University, Seoul (Korea, Republic of); Park, I. W. [Korea Basic Science Institute, Seoul (Korea, Republic of); Park, Y. J. [Korea Institute of Science and Technology, Seoul (Korea, Republic of)

    2004-11-15

    We have studied the electrical properties of InAs/InP self-assembled quantum dots (SAQDs) with GaAs and InGaAs thin layers by capacitance-voltage and deep level transient spectroscopy measurements. The thermal activation energies for electron emission from InAs/InP SAQDs with 5 mono-layers GaAs and 17 mono-layers InGaAs insertion were obtained 0.60 eV and 0.54 eV, respectively, and that in normal QD sample without insertion layer appeared 0.57 eV. On the other hand, the capture barrier heights of QDs with GaAs and InGaAs inserted samples and without insertion were measured 0.24 eV, 0.08 eV and 0.18 eV, respectively, from GaAs conduction band edge. These results show that the strain in the QDs layer effects to the capture barrier height as well as the quantum confined level.

  4. Orienterend onderzoek naar de bepaling van het gehalte aan glucosinolaten in raapzaad met behulp van NIRS

    NARCIS (Netherlands)

    Frankhuizen, R.; Munsteren, van A.J.; Veen, van der N.G.; Herstel, H.

    1987-01-01

    Met behulp van een research Nabij Infrarood Reflectie Spectrometer (NIRS) (Technicon Infra-Alyzer 500) is oriënterend onderzoek uitgevoerd naar de bepaling van het gehalte aan glucosinolaten in raapzaad met behulp van NIRS.

  5. Effect of nitrate and acetylene on nirS, cnorB, and nosZ expression and denitrification activity in Pseudomonas mandelii.

    Science.gov (United States)

    Saleh-Lakha, Saleema; Shannon, Kelly E; Henderson, Sherri L; Zebarth, Bernie J; Burton, David L; Goyer, Claudia; Trevors, Jack T

    2009-08-01

    Nitrate acts as an electron acceptor in the denitrification process. The effect of nitrate in the range of 0 to 1,000 mg/liter on Pseudomonas mandelii nirS, cnorB, and nosZ gene expression was studied, using quantitative reverse transcription-quantitative PCR. Denitrification activity was measured by using the acetylene blockage method and gas chromatography. The effect of acetylene on gene expression was assessed by comparing denitrification gene expression in P. mandelii culture grown in the presence or absence of acetylene. The higher the amount of NO(3)(-) present, the greater the induction and the longer the denitrification genes remained expressed. nirS gene expression reached a maximum at 2, 4, 4, and 6 h in cultures grown in the presence of 0, 10, 100, and 1,000 mg of KNO(3)/liter, respectively, while induction of nirS gene ranged from 12- to 225-fold compared to time zero. cnorB gene expression also followed a similar trend. nosZ gene expression did not respond to NO(3)(-) treatment under the conditions tested. Acetylene decreased nosZ gene expression but did not affect nirS or cnorB gene expression. These results showed that nirS and cnorB responded to nitrate concentrations; however, significant denitrification activity was only observed in culture with 1,000 mg of KNO(3)/liter, indicating that there was no relationship between gene expression and denitrification activity under the conditions tested.

  6. Characterization, catalyzed water oxidation and anticancer activities of a NIR BODIPY-Mn polymer

    Science.gov (United States)

    Lan, Ya-Quan; Xiao, Ke-Jing; Wu, Yun-Jie; Chen, Qiu-Yun

    2017-04-01

    To obtain near-IR absorbing biomaterials as fluorescence cellular imaging and anticancer agents for hypoxic cancer cell, a nano NIR fluorescence Mn(III/IV) polymer (PMnD) was spectroscopically characterized. The PMnD shows strong emission at 661 nm when excited with 643 nm. Furthermore, PMnD can catalyze water oxidation to generate dioxygen when irradiated by red LED light (10 W). In particular, the PMnD can enter into HepG-2 cells and mitochondria. Both anticancer activity and the inhibition of the expression of HIF-1α for PMnD were concentration dependent. Our results demonstrate that PMnD can be developed as mitochondria targeted imaging agents and new inhibitors for HIF-1 in hypoxic cancer cells.

  7. Crystal growth of compound semiconductors in a low-gravity environment (InGaAs crystals) (M-22)

    Science.gov (United States)

    Tatsumi, Masami

    1993-01-01

    Compound semiconductor crystals, such as gallium arsenide and indium phosphide crystals, have many interesting properties that silicon crystals lack, and they are expected to be used as materials for optic and/or electro-optic integrated devices. Generally speaking, alloy semiconductors, which consist of more than three elements, demonstrate new functions. For example, values of important parameters, such as lattice constant and emission wavelength, can be chosen independently. However, as it is easy for macroscopic and/or microscopic fluctuations of composition to occur in alloy semiconductor crystals, it is difficult to obtain crystals having homogeneous properties. Macroscopic change of composition in a crystal is caused by the segregation phenomenon. This phenomenon is due to a continuous change in the concentration of constituent elements at the solid-liquid interfacing during solidification. On Earth, attempts were made to obtain a crystal with homogeneous composition by maintaining a constant melt composition near the solid-liquid interface, through suppression of the convection flow of the melt by applying a magnetic field. However, the attempt was not completely successful. Convective flow does not occur in microgravity because the gravity in space is from four to six orders of magnitude less than that on Earth. In such a case, mass transfer in the melt is dominated by the diffusion phenomenon. So, if crystal growth is carried out at a rate that is higher than the rate of mass transfer due to this phenomenon, it is expected that crystals having a homogeneous composition will be obtained. In addition, it is also possible that microscopic composition fluctuations (striation) may disappear because microscopic fluctuations diminish in the absence of convection. We are going to grow a bulk-indium gallium arsenide (InGaAs) crystal using the gradient heating furnace (GHF) in the first material processing test (FMPT). The structure of the sample is shown where InGaAs

  8. NIR Electrofluorochromic Properties of Aza-Boron-dipyrromethene Dyes.

    Science.gov (United States)

    Lim, Hanwhuy; Seo, Seogjae; Pascal, Simon; Bellier, Quentin; Rigaut, Stéphane; Park, Chihyun; Shin, Haijin; Maury, Olivier; Andraud, Chantal; Kim, Eunkyoung

    2016-01-06

    The photophysical properties of near-infrared (NIR) emissive aza-boron-dipyrromethene (aza-BDP) dyes incorporating nitrofluorene and alkoxy decorations were intensively investigated. Their highly reversible one-electron reduction process showed characteristic electrofluorochromic (EF) properties in the NIR range, depending on the substituents. The nitrofluorene ethynyl-substituted (Type I) dyes showed smaller EF effects than the alkoxy-containing (Type II) dyes because of the difference in their intrinsic fluorescence contrast between the neutral and reduced states (radical anion). In addition, the Type II chromophores showed a larger diffusion coefficient for ion transport, which enhanced the EF contrast and the response time for the fluorescence change at a given step potential. With an optimized condition, the NIR EF ON/OFF ratio reached a value of 6.1 and a long cyclability over 1000 EF cycles between -0.4 V and +0.4 V switching potentials, with approximately 20% loss of the initial ON/OFF switching ratio. The NIR EF switching was visually observed through a visible light cut-off filter, featuring high fluorescence contrast.

  9. Detection of flaws in hazelnuts using VIS/NIR spectroscopy

    Science.gov (United States)

    The feasibility of VIS/NIR spectroscopy for detection of flaws in hazelnut kernels was demonstrated. Feature datasets comprising raw absorbance values, raw absorbance Ratios (Abs['1] : Abs['2]) and Differences (Abs['1] – Abs['2]) for all possible pairs of wavelengths from 306.5 nm to 1710.9 nm were ...

  10. Extendable nickel complex tapes that reach NIR absorptions.

    Science.gov (United States)

    Audi, Hassib; Chen, Zhongrui; Charaf-Eddin, Azzam; D'Aléo, Anthony; Canard, Gabriel; Jacquemin, Denis; Siri, Olivier

    2014-12-14

    Stepwise synthesis of linear nickel complex oligomer tapes with no need for solid-phase support has been achieved. The control of the length in flat arrays allows a fine-tuning of the absorption properties from the UV to the NIR region.

  11. Images

    Data.gov (United States)

    National Aeronautics and Space Administration — Images for the website main pages and all configurations. The upload and access points for the other images are: Website Template RSW images BSCW Images HIRENASD...

  12. Near-infrared operating lamp for intraoperative molecular imaging of a mediastinal tumor

    OpenAIRE

    2016-01-01

    Background Near-Infrared (NIR) intraoperative molecular imaging is a new diagnostic modality utilized during cancer surgery for the identification of tumors, metastases and lymph nodes. Surgeons typically use headlamps during an operation to increase visible light; however, these light sources are not adapted to function simultaneously with NIR molecular imaging technology. Here, we design a NIR cancelling headlamp and utilize it during surgery to assess whether intraoperative molecular imagi...

  13. fNIRS exhibits weak tuning to hand movement direction.

    Science.gov (United States)

    Waldert, Stephan; Tüshaus, Laura; Kaller, Christoph P; Aertsen, Ad; Mehring, Carsten

    2012-01-01

    Functional near-infrared spectroscopy (fNIRS) has become an established tool to investigate brain function and is, due to its portability and resistance to electromagnetic noise, an interesting modality for brain-machine interfaces (BMIs). BMIs have been successfully realized using the decoding of movement kinematics from intra-cortical recordings in monkey and human. Recently, it has been shown that hemodynamic brain responses as measured by fMRI are modulated by the direction of hand movements. However, quantitative data on the decoding of movement direction from hemodynamic responses is still lacking and it remains unclear whether this can be achieved with fNIRS, which records signals at a lower spatial resolution but with the advantage of being portable. Here, we recorded brain activity with fNIRS above different cortical areas while subjects performed hand movements in two different directions. We found that hemodynamic signals in contralateral sensorimotor areas vary with the direction of movements, though only weakly. Using these signals, movement direction could be inferred on a single-trial basis with an accuracy of ∼65% on average across subjects. The temporal evolution of decoding accuracy resembled that of typical hemodynamic responses observed in motor experiments. Simultaneous recordings with a head tracking system showed that head movements, at least up to some extent, do not influence the decoding of fNIRS signals. Due to the low accuracy, fNIRS is not a viable alternative for BMIs utilizing decoding of movement direction. However, due to its relative resistance to head movements, it is promising for studies investigating brain activity during motor experiments.

  14. [Proximate analysis of straw by near infrared spectroscopy (NIRS)].

    Science.gov (United States)

    Huang, Cai-jin; Han, Lu-jia; Liu, Xian; Yang, Zeng-ling

    2009-04-01

    Proximate analysis is one of the routine analysis procedures in utilization of straw for biomass energy use. The present paper studied the applicability of rapid proximate analysis of straw by near infrared spectroscopy (NIRS) technology, in which the authors constructed the first NIRS models to predict volatile matter and fixed carbon contents of straw. NIRS models were developed using Foss 6500 spectrometer with spectra in the range of 1,108-2,492 nm to predict the contents of moisture, ash, volatile matter and fixed carbon in the directly cut straw samples; to predict ash, volatile matter and fixed carbon in the dried milled straw samples. For the models based on directly cut straw samples, the determination coefficient of independent validation (R2v) and standard error of prediction (SEP) were 0.92% and 0.76% for moisture, 0.94% and 0.84% for ash, 0.88% and 0.82% for volatile matter, and 0.75% and 0.65% for fixed carbon, respectively. For the models based on dried milled straw samples, the determination coefficient of independent validation (R2v) and standard error of prediction (SEP) were 0.98% and 0.54% for ash, 0.95% and 0.57% for volatile matter, and 0.78% and 0.61% for fixed carbon, respectively. It was concluded that NIRS models can predict accurately as an alternative analysis method, therefore rapid and simultaneous analysis of multicomponents can be achieved by NIRS technology, decreasing the cost of proximate analysis for straw.

  15. Portable Remote Imaging Spectrometer (PRISM) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Develop an UV-NIR (350nm to 1050 nm) portable remote imaging spectrometer (PRISM) for flight on a variety of airborne platforms with high SNR and response...

  16. On the distance of the Magellanic Clouds using Cepheid NIR and optical-NIR Period Wesenheit Relations

    CERN Document Server

    Inno, L; Bono, G; Caputo, F; Buonanno, R; Genovali, K; Laney, C D; Marconi, M; Piersimoni, A M; Primas, F; Romaniello, M

    2012-01-01

    We present the largest near-infrared (NIR) data sets, $JHKs$, ever collected for classical Cepheids in the Magellanic Clouds (MCs). We selected fundamental (FU) and first overtone (FO) pulsators, and found 4150 (2571 FU, 1579 FO) Cepheids for Small Magellanic Cloud (SMC) and 3042 (1840 FU, 1202 FO) for Large Magellanic Cloud (LMC). Current sample is 2--3 times larger than any sample used in previous investigations with NIR photometry. We also discuss optical $VI$ photometry from OGLE-III. NIR and optical--NIR Period-Wesenheit (PW) relations are linear over the entire period range ($0.0<\\log P_{\\rm FU} \\le1.65 $) and their slopes are, within the intrinsic dispersions, common between the MCs. These are consistent with recent results from pulsation models and observations suggesting that the PW relations are minimally affected by the metal content. The new FU and FO PW relations were calibrated using a sample of Galactic Cepheids with distances based on trigonometric parallaxes and Cepheid pulsation models. B...

  17. Clinical and angiographic results with the NIR stent: First International NIR Endovascular Stent Study (FINESS-II).

    Science.gov (United States)

    Rutsch, Wolfgang; Kiemeneij, Ferdinand; Colombo, Antonio; Macaya, Carlos; Guermonprez, Jean-Leon; Grip, Lars; Hamburger, Jaap; Umans, Victor; Gotsman, Mervyn; Almagor, Yaron; Morice, Marie-Claude; Garcia, Eulogio; Chevalier, Bernard; Erbel, Raimund; Cobaugh, Michael; Morel, Marie-Angèle; Serruys, Patrick W

    2000-09-01

    BACKGROUND: Although safety and efficacy of the NIR trade mark stent have been reported, the long-term angiographic and clinical outcomes have yet to be investigated. The FINESS-II study (First International NIR Endovascular Stent Study) was designed to assess the procedural safety of single 9 and 16 mm NIR stent implantation, the six-month restenosis rate and finally the six- and 12-month clinical outcome of patients treated with this novel coronary stent. METHODS: Patients with angina and a single de novo lesion in a native coronary artery of >3 and 50% diameter stenosis criterion at six month follow-up was 19% (26/136). At 12 months, the event-free survival rate was 83% (two deaths, one Q-wave and three non-Q-wave myocardial infarctions, four bypass surgery and 17 target lesion revascularizations), while 87% of the patients were free of angina pectoris. CONCLUSION: the outcome of the FINESS-II trial is comparable to those observed in previous stent trials (Benestent II), indicating that the coronary NIR stent is safe and effective as a primary device for the treatment of native coronary artery lesions in patients with (un)stable angina pectoris.

  18. Arrays of Ag split-ring resonators coupled to InGaAs single-quantum-well gain

    CERN Document Server

    Meinzer, Nina; Linden, Stefan; Soukoulis, Costas M; Khitrova, Galina; Hendrickson, Joshua; Olitsky, Joshua D; Gibbs, Hyatt M; Wegener, Martin

    2010-01-01

    We study arrays of silver split-ring resonators operating at around 1.5-{\\mu}m wavelength coupled to an MBE-grown single 12.7-nm thin InGaAs quantum well separated only 4.8 nm from the wafer surface. The samples are held at liquid-helium temperature and are pumped by intense femtosecond optical pulses at 0.81-{\\mu}m center wavelength in a pump-probe geometry. We observe much larger relative transmittance changes (up to about 8%) on the split-ring-resonator arrays as compared to the bare quantum well (not more than 1-2%). We also observe a much more rapid temporal decay component of the differential transmittance signal of 15 ps for the case of split-ring resonators coupled to the quantum well compared to the case of the bare quantum well, where we find about 0.7 ns. The latter observation is ascribed to the Purcell effect that arises from the evanescent coupling of the split-ring resonators to the quantum-well gain. All experimental results are compared with a recently introduced analytical toy model that acc...

  19. Amplitude to phase conversion of InGaAs pin photo-diodes for femtosecond lasers microwave signal generation

    CERN Document Server

    Zhang, W; Lours, M; Seidelin, S; Santarelli, G; Coq, Y Le

    2011-01-01

    When a photo-diode is illuminated by a pulse train from a femtosecond laser, it generates microwaves components at the harmonics of the repetition rate within its bandwidth. The phase of these components (relative to the optical pulse train) is known to be dependent on the optical energy per pulse. We present an experimental study of this dependence in InGaAs pin photo-diodes illuminated with ultra-short pulses generated by an Erbium-doped fiber based femtosecond laser. The energy to phase dependence is measured over a large range of impinging pulse energies near and above saturation for two typical detectors, commonly used in optical frequency metrology with femtosecond laser based optical frequency combs. When scanning the optical pulse energy, the coefficient which relates phase variations to energy variations is found to alternate between positive and negative values, with many (for high harmonics of the repetition rate) vanishing points. By operating the system near one of these vanishing points, the typ...

  20. Indolizine-Squaraines: NIR Fluorescent Materials with Molecularly Engineered Stokes Shifts.

    Science.gov (United States)

    McNamara, Louis E; Rill, Tana A; Huckaba, Aron J; Ganeshraj, Vigneshraja; Gayton, Jacqueline; Nelson, Rachael A; Sharpe, Emily Anne; Dass, Amala; Hammer, Nathan I; Delcamp, Jared H

    2017-09-12

    The development of deep red and near infrared emissive materials with high quantum yields is an important challenge. Several classes of squaraine dyes have demonstrated high quantum yields, but require significantly red-shifted absorptions to access the NIR window. Additionally, squaraine dyes have typically shown narrow Stokes shifts, which limits their use in living biological imaging applications due to dye emission interference with the light source. Through the incorporation of indolizine heterocycles we have synthesized novel indolizine squaraine dyes with increased Stokes shifts (up to >0.119 eV, >50 nm increase) and absorptions substantially further into the NIR region than an indoline squaraine benchmark (726 nm versus 659 nm absorption maxima). These materials have shown significantly enhanced water solubility, which is unique for squaraine dyes without water-solubilizing substituents. Absorption, electrochemical, computational, and fluorescence studies were undertaken and exceptional fluorescence quantum yields of up 12 % were observed with emission curves extending beyond 850 nm. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Music improves verbal memory encoding while decreasing prefrontal cortex activity: an fNIRS study

    Science.gov (United States)

    Ferreri, Laura; Aucouturier, Jean-Julien; Muthalib, Makii; Bigand, Emmanuel; Bugaiska, Aurelia

    2013-01-01

    Listening to music engages the whole brain, thus stimulating cognitive performance in a range of non-purely musical activities such as language and memory tasks. This article addresses an ongoing debate on the link between music and memory for words. While evidence on healthy and clinical populations suggests that music listening can improve verbal memory in a variety of situations, it is still unclear what specific memory process is affected and how. This study was designed to explore the hypothesis that music specifically benefits the encoding part of verbal memory tasks, by providing a richer context for encoding and therefore less demand on the dorsolateral prefrontal cortex (DLPFC). Twenty-two healthy young adults were subjected to functional near-infrared spectroscopy (fNIRS) imaging of their bilateral DLPFC while encoding words in the presence of either a music or a silent background. Behavioral data confirmed the facilitating effect of music background during encoding on subsequent item recognition. fNIRS results revealed significantly greater activation of the left hemisphere during encoding (in line with the HERA model of memory lateralization) and a sustained, bilateral decrease of activity in the DLPFC in the music condition compared to silence. These findings suggest that music modulates the role played by the DLPFC during verbal encoding, and open perspectives for applications to clinical populations with prefrontal impairments, such as elderly adults or Alzheimer’s patients. PMID:24339807

  2. Music improves verbal memory encoding while decreasing prefrontal cortex activity: an fNIRS study

    Directory of Open Access Journals (Sweden)

    Laura eFerreri

    2013-11-01

    Full Text Available Listening to music engages the whole brain, thus stimulating cognitive performance in a range of non purely musical activities such as language and memory tasks. This article addresses an ongoing debate on the link between music and memory for words. While evidence on healthy and clinical populations suggests that music listening can improve verbal memory in a variety of situations, it is still unclear what specific memory process is affected and how. This study was designed to explore the hypothesis that music specifically benefits the encoding part of verbal memory tasks, by providing a richer context for encoding and therefore less demand on the dorsolateral prefrontal cortex (DLPFC. 22 healthy young adults were subjected to functional near-infrared spectroscopy (fNIRS imaging of their bilateral DLPFC while encoding words in the presence of either a music or a silent background. Behavioral data confirmed the facilitating effect of music background during encoding on subsequent item recognition. fNIRS results revealed significantly greater activation of the left hemisphere during encoding (in line with the HERA model of memory lateralization and a sustained, bilateral decrease of activity in the DLPFC in the music condition compared to silence. These findings suggest that music modulates the role played by the DLPFC during verbal encoding, and open perspectives for applications to clinical populations with prefrontal impairments, such as elderly adults or Alzheimer's patients.

  3. Music improves verbal memory encoding while decreasing prefrontal cortex activity: an fNIRS study.

    Science.gov (United States)

    Ferreri, Laura; Aucouturier, Jean-Julien; Muthalib, Makii; Bigand, Emmanuel; Bugaiska, Aurelia

    2013-01-01

    Listening to music engages the whole brain, thus stimulating cognitive performance in a range of non-purely musical activities such as language and memory tasks. This article addresses an ongoing debate on the link between music and memory for words. While evidence on healthy and clinical populations suggests that music listening can improve verbal memory in a variety of situations, it is still unclear what specific memory process is affected and how. This study was designed to explore the hypothesis that music specifically benefits the encoding part of verbal memory tasks, by providing a richer context for encoding and therefore less demand on the dorsolateral prefrontal cortex (DLPFC). Twenty-two healthy young adults were subjected to functional near-infrared spectroscopy (fNIRS) imaging of their bilateral DLPFC while encoding words in the presence of either a music or a silent background. Behavioral data confirmed the facilitating effect of music background during encoding on subsequent item recognition. fNIRS results revealed significantly greater activation of the left hemisphere during encoding (in line with the HERA model of memory lateralization) and a sustained, bilateral decrease of activity in the DLPFC in the music condition compared to silence. These findings suggest that music modulates the role played by the DLPFC during verbal encoding, and open perspectives for applications to clinical populations with prefrontal impairments, such as elderly adults or Alzheimer's patients.

  4. Isoquinoline-based lanthanide complexes: bright NIR optical probes and efficient MRI agents.

    Science.gov (United States)

    Caillé, Fabien; Bonnet, Célia S; Buron, Frédéric; Villette, Sandrine; Helm, Lothar; Petoud, Stéphane; Suzenet, Franck; Tóth, Eva

    2012-02-20

    In the objective of developing ligands that simultaneously satisfy the requirements for MRI contrast agents and near-infrared emitting optical probes that are suitable for imaging, three isoquinoline-based polyaminocarboxylate ligands, L1, L2 and L3, have been synthesized and the corresponding Gd(3+), Nd(3+) and Yb(3+) complexes investigated. The specific challenge of the present work was to create NIR emitting agents which (i) have excitation wavelengths compatible with biological applications and (ii) are able to emit a sufficient number of photons to ensure sensitive NIR detection for microscopic imaging. Here we report the first observation of a NIR signal arising from a Ln(3+) complex in aqueous solution in a microscopy setup. The lanthanide complexes have high thermodynamic stability (log K(LnL) =17.7-18.7) and good selectivity for lanthanide ions versus the endogenous cations Zn(2+), Cu(2+), and Ca(2+) thus preventing transmetalation. A variable temperature and pressure (17)O NMR study combined with nuclear magnetic relaxation dispersion measurements yielded the microscopic parameters characterizing water exchange and rotation. Bishydration of the lanthanide cation in the complexes, an important advantage to obtain high relaxivity for the Gd(3+) chelates, has been demonstrated by (17)O chemical shifts for the Gd(3+) complexes and by luminescence lifetime measurements for the Yb(3+) analogues. The water exchange on the three Gd(3+) complexes is considerably faster (k(ex)(298) = (13.9-15.4) × 10(6) s(-1)) than on commercial Gd(3+)-based contrast agents and proceeds via a dissociative mechanism, as evidenced by the large positive activation volumes for GdL1 and GdL2 (+10.3 ± 0.9 and +10.6 ± 0.9 cm(3) mol(-1), respectively). The relaxivity of GdL1 is doubled at 40 MHz and 298 K in fetal bovine serum (r(1) = 16.1 vs 8.5 mM(-1) s(-1) in HEPES buffer), due to hydrophobic interactions between the chelate and serum proteins. The isoquinoline core allows for the

  5. Study the left prefrontal cortex activity of Chinese children with dyslexia in phonological processing by NIRS

    Science.gov (United States)

    Zhang, Zhili; Li, Ting; Zheng, Yi; Luo, Qingming; Song, Ranran; Gong, Hui

    2006-02-01

    Developmental dyslexia, a kind of prevalent psychological disease, represents that dyslexic children have unexpected difficulties in phonological processing and recognition test of Chinese characters. Some functional imaging technologies, such as fMRI and PET, have been used to study the brain activities of the children with dyslexia whose first language is English. In this paper, a portable, 16-channel, continuous-wave (CW) NIRS instrument was used to monitor the concentration changes of each hemoglobin species when Chinese children did the task of phonological processing and recognition test. The NIRS recorded the hemodynamic changes in the left prefrontal cortex of the children. 20 dyslexia-reading children (10~12 years old) and 20 normal-reading children took part in the phonological processing of Chinese characters including the phonological awareness section and the phonological decoding section. During the phonological awareness section, the changed concentration of deoxy-hemoglobin in dyslexia-reading children were significantly higher (preading children in the left ventrolateral prefrontal cortex (VLPFC). While in the phonological decoding section, both normal and dyslexic reading children had more activity in the left VLPFC, but only normal-reading children had activity in the left middorsal prefrontal cortex. In conclusion, both dyslexic and normal-reading children have activity in the left prefrontal cortex, but the degree and the areas of the prefrontal cortex activity are different between them when they did phonological processing.

  6. [In hospital and mid-term outcome of patients with NIR stent implantation: multicenter ESPORT-NIR registry].

    Science.gov (United States)

    Iñiguez, A; García, E; Seabra, R; Bordes, P; Bethencourt, A; Rigla, J

    2001-05-01

    Despite improvements in the results and techniques of catheter-based revascularization, few studies have evaluated the clinical results of the application of new stent designs. We describe the in-hospital and mid-term outcome of patients undergoing a stent NIR implantation. At least 1 Stent NIR was implanted in 1.004 patients (1.136 lesions) recruited from 50 centers in an international, multicenter, prospective, registry (Spain and Portugal NIR stent registry). Inclusion criteria were objective coronary ischemia related to a severe de novo lesion or first restenosis in native vessels with a reference diameter >= 2.75 mm. The primary end-point was the incidence of major adverse cardiac events within the first 7 months of follow-up. The mean age of the patients was 60 years and 82% were male. Angioplasty was indicated due to unstable angina in 61% of the cases. Stent implantation was successfully achieved in 99.6%. Clinical success (angiographic success without in-hospital major events) was achieved in 98.6% of patients. The rate of angiographic restenosis (> 50% stenosis narrowing) was 16% (CI 95%; 11.7-21.2). The accumulated major cardiac adverse event rate at seven months of follow-up was 8.7%: death (0.9%), acute myocardial infarction (1.2%) and target lesion revascularization (6.6%). In the wide setting of the population included in the ESPORT-NIR registry, stent NIR implantation was a highly effective therapy with a good mid-term clinical and angiographic outcome.

  7. NIR is degraded by the anaphase-promoting complex proteasome pathway

    Directory of Open Access Journals (Sweden)

    Jeong Ho Myong

    2014-01-01

    Full Text Available Novel INHAT Repressor (NIR is a histone acetylation inhibitor that can directly bind histone complexes and the tumor suppressors p53 and p63. Because NIR is mainly localized in the nucleolus and disappears from the nucleolus upon RNase treatment, it is thought to bind RNA or ribonucleoproteins. When NIR moves to the cytoplasm, it is immediately degraded; this degradation was blocked by MG132, a proteasome inhibitor. Furthermore, the central domain of NIR specifically bound APC-CCdh1. These data show that the stability of NIR is governed by the ubiquitin/proteasome pathway.

  8. Determination of Aluminium Content in Aluminium Hydroxide Formulation by FT-NIR Transmittance Spectroscopy

    DEFF Research Database (Denmark)

    Lai, Xuxin; Zheng, Yiwu; Søndergaard, Ib

    2007-01-01

    A method for determining the aluminium content of an aluminium hydroxide suspension using near infrared (NIR) transmittance spectroscopy has been developed. Inductively coupled plasma-atomic emission spectroscopy (ICP-AES) was used as reference method. The factors influencing the NIR analysis......-AES and NIR transmittance spectroscopy exhibit comparable precision and accuracy. The NIR method provides several advantages: no complicated sample preparation; easy to operate; fast and non-destructive. In conclusion, NIR transmittance spectroscopy can be an alternative analytical method for determining...

  9. A novel in-line NIR spectroscopy application for the monitoring of tablet film coating in an industrial scale process.

    Science.gov (United States)

    Möltgen, C-V; Puchert, T; Menezes, J C; Lochmann, D; Reich, G

    2012-04-15

    Film coating of tablets is a multivariate pharmaceutical unit operation. In this study an innovative in-line Fourier-Transform Near-Infrared Spectroscopy (FT-NIRS) application is described which enables real-time monitoring of a full industrial scale pan coating process of heart-shaped tablets. The tablets were coated with a thin hydroxypropyl methylcellulose (HPMC) film of up to approx. 28 μm on the tablet face as determined by SEM, corresponding to a weight gain of 2.26%. For a better understanding of the aqueous coating process the NIR probe was positioned inside the rotating tablet bed. Five full scale experimental runs have been performed to evaluate the impact of process variables such as pan rotation, exhaust air temperature, spray rate and pan load and elaborate robust and selective quantitative calibration models for the real-time determination of both coating growth and tablet moisture content. Principal Component (PC) score plots allowed each coating step, namely preheating, spraying and drying to be distinguished and the dominating factors and their spectral effects to be identified (e.g. temperature, moisture, coating growth, change of tablet bed density, and core/coat interactions). The distinct separation of HPMC coating growth and tablet moisture in different PCs enabled a real-time in-line monitoring of both attributes. A PLS calibration model based on Karl Fischer reference values allowed the tablet moisture trajectory to be determined throughout the entire coating process. A 1-latent variable iPLS weight gain calibration model with calibration samples from process stages dominated by the coating growth (i.e. ≥ 30% of the theoretically applied amount of coating) was sufficiently selective and accurate to predict the progress of the thin HPMC coating layer. At-line NIR Chemical Imaging (NIR-CI) in combination with PLS Discriminant Analysis (PLSDA) verified the HPMC coating growth and physical changes at the core/coat interface during the initial

  10. Shed a light of wireless technology on portable mobile design of NIRS

    Science.gov (United States)

    Sun, Yunlong; Li, Ting

    2016-03-01

    Mobile internet is growing rapidly driven by high-tech companies including the popular Apple and Google. The wireless mini-NIRS is believed to deserve a great spread future, while there is sparse report on wireless NIRS device and even for the reported wireless NIRS, its wireless design is scarcely presented. Here we focused on the wireless design of NIRS devices. The widely-used wireless communication standards and wireless communication typical solutions were employed into our NIRS design and then compared on communication efficiency, distance, error rate, low-cost, power consumption, and stabilities, based on the requirements of NIRS applications. The properly-performed wireless communication methods matched with the characteristics of NIRS are picked out. Finally, we realized one recommended wireless communication in our NIRS, developed a test platform on wireless NIRS and tested the full properties on wireless communication. This study elaborated the wireless communication methods specified for NIRS and suggested one implementation with one example fully illustrated, which support the future mobile design on NIRS devices.

  11. Polarimetric imaging of retinal disease by polarization sensitive SLO

    Science.gov (United States)

    Miura, Masahiro; Elsner, Ann E.; Iwasaki, Takuya; Goto, Hiroshi

    2015-03-01

    Polarimetry imaging is used to evaluate different features of the macular disease. Polarimetry images were recorded using a commercially- available polarization-sensitive scanning laser opthalmoscope at 780 nm (PS-SLO, GDx-N). From data sets of PS-SLO, we computed average reflectance image, depolarized light images, and ratio-depolarized light images. The average reflectance image is the grand mean of all input polarization states. The depolarized light image is the minimum of crossed channel. The ratio-depolarized light image is a ratio between the average reflectance image and depolarized light image, and was used to compensate for variation of brightness. Each polarimetry image is compared with the autofluorescence image at 800 nm (NIR-AF) and autofluorescence image at 500 nm (SW-AF). We evaluated four eyes with geographic atrophy in age related macular degeneration, one eye with retinal pigment epithelium hyperplasia, and two eyes with chronic central serous chorioretinopathy. Polarization analysis could selectively emphasize different features of the retina. Findings in ratio depolarized light image had similarities and differences with NIR-AF images. Area of hyper-AF in NIR-AF images showed high intensity areas in the ratio depolarized light image, representing melanin accumulation. Areas of hypo-AF in NIR-AF images showed low intensity areas in the ratio depolarized light images, representing melanin loss. Drusen were high-intensity areas in the ratio depolarized light image, but NIR-AF images was insensitive to the presence of drusen. Unlike NIR-AF images, SW-AF images showed completely different features from the ratio depolarized images. Polarization sensitive imaging is an effective tool as a non-invasive assessment of macular disease.

  12. Automatic determination of moisture content in biofuels based on NIR-measurements; Automatisk fukthaltsbestaemning av biobraenslen med NIR-metoden

    Energy Technology Data Exchange (ETDEWEB)

    Berg, Magnus; Wiklund, Sven Erik [AaF-Process AB, Stockholm (Sweden); Karlsson, Mikael; Tryzell, Robert [Bestwood AB, Sundbyberg (Sweden)

    2005-07-01

    The determination of moisture content of biofuel is of large importance for the energy sector. The used methods for moisture determination are based on fuels samples taken from the bulk followed by drying and weighing. To be able to instead determine the moisture content based on a method with good accuracy and with a short response time would be a large improvement. Both for the fuel sampling and the following analysis there are Swedish standards but concerning the fuel sampling the standards are often not followed. The main reason is the difficulties to sample fuel samples from different depth from a delivery. This is one of the reasons that some plants have installed mechanical samplers but the investment cost for these is relatively high. The aim of this project was to investigate the use of the NIR-method for automatic moisture determination in biofuels. Within the project the NIR-method was used to determine the moisture content on withdrawn fuel samples, in addition the possibility to integrate the NIR-method in an automatic sampling system is also described. A large number of samples, in total over 200 samples, have been evaluated with the NIR-method and compared with the reference method, oven drying and gravimetric determination of moisture content. That the NIR-method can be used to determine moisture content in a number of well defined materials have previously been shown. In this report it has moreover been shown that the method can be used under the conditions at the fuel delivery station and for a large spectrum of biofuels. The accuracy that can be achieved with the NIR-method is in the same magnitude as the standard method, i.e. the reference method used for the measurements. Altogether this shows that the NIR-method is an interesting alternative for integration in an automatic measurement system for determination of fuel moisture content in biofuels. To be able to use the NIR-method for automatic determination of fuel moisture content at the

  13. Gold nanoshell-decorated silicone surfaces for the near-infrared (NIR) photothermal destruction of the pathogenic bacterium E. faecalis.

    Science.gov (United States)

    Khantamat, Orawan; Li, Chien-Hung; Yu, Fei; Jamison, Andrew C; Shih, Wei-Chuan; Cai, Chengzhi; Lee, T Randall

    2015-02-25

    Catheter-related infections (CRIs) are associated with the formation of pathogenic biofilms on the surfaces of silicone catheters, which are ubiquitous in medicine. These biofilms provide protection against antimicrobial agents and facilitate the development of bacterial resistance to antibiotics. The application of photothermal agents on catheter surfaces is an innovative approach to overcoming biofilm-generated CRIs. Gold nanoshells (AuNSs) represent a promising photothermal tool, because they can be used to generate heat upon exposure to near-infrared (NIR) radiation, are biologically inert at physiological temperatures, and can be engineered for the photothermal ablation of cells and tissue. In this study, AuNSs functionalized with carboxylate-terminated organosulfur ligands were attached to model catheter surfaces and tested for their effectiveness at killing adhered Enterococcus faecalis (E. faecalis) bacteria. The morphology of the AuNSs was characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM), while the elemental composition was characterized by energy-dispersive X-ray spectroscopy (EDX) and X-ray photoelectron spectroscopy (XPS). Furthermore, optical and photothermal properties were acquired by ultraviolet-visible (UV-vis) spectroscopy and thermographic imaging with an infrared camera, respectively. Bacterial survival studies on AuNS-modified surfaces irradiated with and without NIR light were evaluated using a colony-formation assay. These studies demonstrated that AuNS-modified surfaces, when illuminated with NIR light, can effectively kill E. faecalis on silicone surfaces.

  14. Morphology Tuning of Self-Assembled Perylene Monoimide from Nanoparticles to Colloidosomes with Enhanced Excimeric NIR Emission for Bioimaging.

    Science.gov (United States)

    Jana, Avijit; Bai, Linyi; Li, Xin; Ågren, Hans; Zhao, Yanli

    2016-01-27

    Organic near-infrared (NIR) fluorescent probes have been recognized as an emerging class of materials exhibiting a great potential in advanced bioanalytical applications. However, synthesizing such organic probes that could simultaneously work in the NIR spectral range and have large Stokes shift, high stability in biological systems, and high photostability have been proven challenging. In this work, aggregation induced excimeric NIR emission in aqueous media was observed from a suitably substituted perylene monoimide (PeIm) dye. Controlled entrapment of the dye into pluronic F127 micellar system to preserve its monomeric green emission in aqueous media was also established. The aggregation process of the PeIm dye to form organic nanoparticles (NPs) was evaluated experimentally by the means of transmission electron microscope imaging as well as theoretically by the molecular dynamics simulation studies. Tuning the morphology along with the formation of colloidosomes by the controlled self-aggregation of PeIm NPs in aqueous suspension was demonstrated successfully. Finally, both excimeric and monomeric emissive PeIm NPs as well as PeIm colloidosomes were employed for the bioimaging in vitro.

  15. Functional near-infrared spectroscopy (fNIRS) of brain function during active balancing using a video game system.

    Science.gov (United States)

    Karim, Helmet; Schmidt, Benjamin; Dart, Dwight; Beluk, Nancy; Huppert, Theodore

    2012-03-01

    Functional near-infrared spectroscopy (fNIRS) is a portable, non-invasive, brain imaging technology that uses low levels of non-ionizing light to record changes in cerebral blood flow in the brain through optical sensors placed on the surface of the scalp. These signals are recorded via flexible fiber optic cables, which allow neuroimaging experiments to be conducted on participants while performing tasks such as standing or walking. FNIRS has the potential to provide new insights into the evolution of brain activation during ambulatory motor learning tasks and standing tasks to probe balance and vestibular function. In this study, a 32 channel fNIRS system was used to record blood flow changes in the frontal, motor, sensory, and temporal cortices during active balancing associated with playing a video game simulating downhill skiing (Nintendo Wii™; Wii-fit™). Using fNIRS, we found activation of superior temporal gyrus, which was modulated by the difficulty of the balance task. This region had been previously implicated in vestibular function from other animal and human studies. Copyright © 2011 Elsevier B.V. All rights reserved.

  16. The low-mass YSO CB230-A: investigating the protostar and its jet with NIR spectroscopy and Spitzer observations

    CERN Document Server

    Massi, Fabrizio; Brand, Jan; di Fabrizio, Luca; Wouterloot, Jan

    2008-01-01

    A jet from the low-mass YSO CB230-A had been discovered in NIR narrow-band images. We aim to investigate the physical properties of the region from where the jet is launched. Our analysis was carried out using low-resolution NIR spectra acquired with the camera NICS at the TNG telescope, with JH and HK grisms and a 1 arcsec-wide slit. These observational data were complemented with infrared photometric data from the Spitzer space telescope archive. The relevant physical properties of CB230-A were constrained by SED fitting of fluxes from the NIR to the mm. The YSO spectrum exhibits a significant number of atomic and molecular emission and absorption features. The characteristics of this spectrum suggest that we are observing a region in the close vicinity of CB230-A, i. e. its photosphere and/or an active accretion disk. The spectra of the knots in the jet contain a large number of emission lines, including a rich set of [FeII] lines. Emission due to H2 and [FeII] are not spatially correlated, confirming that...

  17. Quenched Assembly of NIR-Active Gold Nanoclusters Capped with Strongly Bound Ligands by Tuning Particle Charge via pH and Salinity.

    Science.gov (United States)

    Stover, Robert J; Murthy, Avinash K; Nie, Golay D; Gourisankar, Sai; Dear, Barton J; Truskett, Thomas M; Sokolov, Konstantin V; Johnston, Keith P

    2014-07-03

    Gold nanospheres coated with a binary monolayer of bound citrate and cysteine ligands were assembled into nanoclusters, in which the size and near-infrared (NIR) extinction were tuned by varying the pH and concentration of added NaCl. During full evaporation of an aqueous dispersion of 4.5 ± 1.8 nm Au primary particles, the nanoclusters were formed and quenched by the triblock copolymer polylactic acid (PLA)(1K)-b-poly(ethylene glycol) (PEG)(10K)-b-PLA(1K), which also provided steric stabilization. The short-ranged depletion and van der Waals attractive forces were balanced against longer ranged electrostatic repulsion to tune the nanocluster diameter and NIR extinction. Upon lowering the pH from 7 to 5 at a given salinity, the magnitude of the charge on the primary particles decreased, such that the weaker electrostatic repulsion increased the hydrodynamic diameter and, consequently, NIR extinction of the clusters. At a given pH, as the concentration of NaCl was increased, the NIR extinction decreased monotonically. Furthermore, the greater screening of the charges on the nanoclusters weakened the interactions with PLA(1K)-b-PEG(10K)-b-PLA(1K) and thus lowered the amount of adsorbed polymer on the nanocluster surface. The generalization of the concept of self-assembly of small NIR-active nanoclusters to include a strongly bound thiol and the manipulation of the morphologies and NIR extinction by variation of pH and salinity not only is of fundamental interest but also is important for optical biomedical imaging and therapy.

  18. Analysis of Twenty-Two Performance Properties of Diesel, Gasoline, and Jet Fuels Using a Field-Portable Near-Infrared (NIR) Analyzer.

    Science.gov (United States)

    Brouillette, Carl; Smith, Wayne; Shende, Chetan; Gladding, Zack; Farquharson, Stuart; Morris, Robert E; Cramer, Jeffrey A; Schmitigal, Joel

    2016-05-01

    The change in custody of fuel shipments at depots, pipelines, and ports could benefit from an analyzer that could rapidly verify that properties are within specifications. To meet this need, the design requirements for a fuel analyzer based on near-infrared (NIR) spectroscopy, such as spectral region and resolution, were examined. It was found that the 1000 to 1600 nm region, containing the second CH overtone and combination vibrational modes of hydrocarbons, provided the best near-infrared to fuel property correlations when path length was taken into account, whereas 4 cm(-1) resolution provided only a modest improvement compared to 16 cm(-1) resolution when four or more latent variables were used. Based on these results, a field-portable near-infrared fuel analyzer was built that employed an incandescent light source, sample compartment optics to hold 2 mL glass sample vials with ∼1 cm path length, a transmission grating, and a 256 channel InGaAs detector that measured the above stated wavelength range with 5-6 nm (∼32 cm(-1)) resolution. The analyzer produced high signal-to-noise ratio (SNR) spectra of samples in 5 s. Twenty-two property correlation models were developed for diesel, gasoline, and jet fuels with root mean squared error of correlation - cross-validated values that compared favorably to corresponding ASTM reproducibility values. The standard deviations of predicted properties for repeat measurements at 4, 24, and 38℃ were often better than ASTM documented repeatability values. The analyzer and diesel property models were tested by measuring seven diesel samples at a local ASTM certification laboratory. The standard deviations between the analyzer determined values and the ASTM measured values for these samples were generally better than the model root mean squared error of correlation-cross-validated values for each property.

  19. Single camera imaging system for color and near-infrared fluorescence image guided surgery.

    Science.gov (United States)

    Chen, Zhenyue; Zhu, Nan; Pacheco, Shaun; Wang, Xia; Liang, Rongguang

    2014-08-01

    Near-infrared (NIR) fluorescence imaging systems have been developed for image guided surgery in recent years. However, current systems are typically bulky and work only when surgical light in the operating room (OR) is off. We propose a single camera imaging system that is capable of capturing NIR fluorescence and color images under normal surgical lighting illumination. Using a new RGB-NIR sensor and synchronized NIR excitation illumination, we have demonstrated that the system can acquire both color information and fluorescence signal with high sensitivity under normal surgical lighting illumination. The experimental results show that ICG sample with concentration of 0.13 μM can be detected when the excitation irradiance is 3.92 mW/cm(2) at an exposure time of 10 ms.

  20. NIR Analysis of Powder Mixing Quality in a Ribbon Blender

    Science.gov (United States)

    Goodridge, Chris; Duong, Nhat-Hang; Muzzio, Fernando

    2001-11-01

    We present experimental results on powder mixing performed in a common industrial mixer, the batch ribbon blender. Our experiments explore the effectiveness of this device on mixture quality as a function of fill level, loading pattern, ribbon speed, mixing time, and ribbon angle. We study two powder formulations consisting of common compounds used in food and pharmaceutical processing. Mixture quality is evaluated by core sampling throughout the blender and determining the composition of small samples using NIR spectroscopy. We use the spectra from NIR to calculate the intensity and scale of segregation for the three-dimensional mixing region. The mixing rates in the axial and radial directions are obtained from plots of composition variance vs. mixing time. We examine the effects of ribbon speed and fill level as the main parameters affecting mixing rate. Dead regions that remain isolated from the remainder of the flow are identified.

  1. NIR FRET Fluorophores for Use as an Implantable Glucose Biosensor

    Directory of Open Access Journals (Sweden)

    Majed DWEIK

    2008-12-01

    Full Text Available Development of an in vivo optical sensor requires the utilization of Near Infra Red (NIR fluorophores due to their ability to operate within the biological tissue window. Alexa Fluor 750 (AF750 and Alexa Fluor 680 (AF680 were examined as potential NIR fluorophores for an in vivo fluorescence resonance energy transfer (FRET glucose biosensor. AF680 and AF750 found to be a FRET pair and percent energy transfer was calculated. Next, the tested dye pair was utilized in a competitive binding assay in order to detect glucose. Concanavalin A (Con A and dextran have binding affinity, but in the presence of glucose, glucose displaces dextran due to its higher affinity to Con A than dextran. Finally, the percent signal transfer through porcine skin was examined. The results showed with approximately 4.0 mm porcine skin thickness, 1.98 % of the fluorescence was transmitted and captured by the detector.

  2. A NIR Flare of the Quasar PKS0446+112

    Science.gov (United States)

    Carrasco, L.; Porras, A.; Escobedo, G.; Recillas, E.; Chabushyan, V.; Carraminana, A.; Mayya, D.

    2014-01-01

    We report on the NIR flare of the high redshift quasar PKS0446+112 (z=1.207), also known as CGRaBSJ0449+1121, associated with the gamma-ray source 1FGL0448.6+1118. The source has shown Gamma-ray flares in the past. Our NIR photometry for this source shows that on Jan 4th,2014 (JD2456661.773275), the object brightness corresponded to J = 15.43+/- 0.04, H = 14.210 +/- 0.04 and Ks = 13.455 +/- 0.06. These values are about 1 magnitud brighter than our previous photometry, obtained on JD2456609, for this field.

  3. [EMD Time-Frequency Analysis of Raman Spectrum and NIR].

    Science.gov (United States)

    Zhao, Xiao-yu; Fang, Yi-ming; Tan, Feng; Tong, Liang; Zhai, Zhe

    2016-02-01

    This paper analyzes the Raman spectrum and Near Infrared Spectrum (NIR) with time-frequency method. The empirical mode decomposition spectrum becomes intrinsic mode functions, which the proportion calculation reveals the Raman spectral energy is uniform distributed in each component, while the NIR's low order intrinsic mode functions only undertakes fewer primary spectroscopic effective information. Both the real spectrum and numerical experiments show that the empirical mode decomposition (EMD) regard Raman spectrum as the amplitude-modulated signal, which possessed with high frequency adsorption property; and EMD regards NIR as the frequency-modulated signal, which could be preferably realized high frequency narrow-band demodulation during first-order intrinsic mode functions. The first-order intrinsic mode functions Hilbert transform reveals that during the period of empirical mode decomposes Raman spectrum, modal aliasing happened. Through further analysis of corn leaf's NIR in time-frequency domain, after EMD, the first and second orders components of low energy are cut off, and reconstruct spectral signal by using the remaining intrinsic mode functions, the root-mean-square error is 1.001 1, and the correlation coefficient is 0.981 3, both of these two indexes indicated higher accuracy in re-construction; the decomposition trend term indicates the absorbency is ascending along with the decreasing to wave length in the near-infrared light wave band; and the Hilbert transform of characteristic modal component displays, 657 cm⁻¹ is the specific frequency by the corn leaf stress spectrum, which could be regarded as characteristic frequency for identification.

  4. Temperature dependent NIR emitting lanthanide-PMO/silica hybrid materials.

    Science.gov (United States)

    Kaczmarek, Anna M; Esquivel, Dolores; Ouwehand, Judith; Van Der Voort, Pascal; Romero-Salguero, Francisco J; Van Deun, Rik

    2017-06-28

    Two materials - a mesoporous silica (MS) and a periodic mesoporous organosilica (PMO) functionalized with dipyridyl-pyridazine (dppz) units were grafted with near-infrared (NIR) emitting lanthanide (Nd(3+), Er(3+), Yb(3+)) complexes in an attempt to obtain hybrid NIR emitting materials. The parent materials: dppz-vSilica and dppz-ePMO were prepared by a hetero Diels-Alder reaction between 3,6-di(2-pyridyl)-1,2,4,5-tetrazine (dptz) and the double bonds of either ethenylene-bridged PMO (ePMO) or vinyl-silica (vSilica) and subsequent oxidation. The dppz-vSilica is reported here for the first time. The prepared lanthanide-PMO/silica hybrid materials were studied in depth for their luminescence properties at room temperature and chosen Nd(3+) and Yb(3+) samples also at low temperature (as low as 10 K). We show that both the dppz-vSilica and dppz-ePMO materials can be used as "platforms" for obtaining porous materials showing NIR luminescence. To obtain NIR emission these materials can be excited either in the UV or Vis region (into the π→π* transitions of the ligands or directly into the f-f transitions of the Ln(3+) ions). More interestingly, when functionalized with Nd(3+) or Yb(3+)β-diketonate complexes these materials showed interesting luminescence properties over a wide temperature range (10-360 K). The Yb(3+) materials were investigated for their potential use as ratiometric temperature sensors.

  5. Relationship between muscle oxygenation by NIRS and blood lactate

    Energy Technology Data Exchange (ETDEWEB)

    Xu Guodong [School of Physical Education, Jianghan University, Hubei Wuhan 430056 (China); Mao Zongzhen; Ye Yanjie; Lv Kunru, E-mail: xguodong@wipe.edu.cn [School of Health Sciences, Wuhan Institute of Physical Education, Hubei Wuhan 430079 (China)

    2011-01-01

    The aim of the study was to investigate the relationship of muscle oxygenation in term of oxy-hemoglobin concentration change ({Delta}HbO{sub 2}) by NIRS and blood lactate (BLA) in local skeletal muscle and evaluate the capability of NIRS in the research of exercise physiology Twenty-three athlete in the national fin-swimming team took the increasing load training on the power bicycle while their {Delta}HbO{sub 2} and BLA were simultaneously recorded. The initial powers used in the training were set as 100 w for males and 40 w for females. During the experiment, the power kept constant for 3 min before each abrupt increment of 30 w until the limit of the athlete's capability. Statistical analysis and data visualization were performed. Following the increasing load training, {Delta}HbO{sub 2} step-likely increased in the phase of aerobic metabolism but linearly decreased in the phase of anaerobic metabolism. The variation tendency of BLA was the same as {Delta}HbO{sub 2} and the concurrency of crucial turning points between {Delta}HbO{sub 2} and BLA was revealed. This relationship between {Delta}HbO{sub 2} and BLA presented in the increasing load training suggested that {Delta}HbO{sub 2} might be capable for taking the place of the invasively measured parameter BLA. Considering that {Delta}HbO{sub 2} can be noninvasively measured by NIRS, {Delta}HbO{sub 2} has the potential in the evaluation of athletes' physiological function and training effect on the athletes and accordingly NIRS can be well used in this field.

  6. [A new algorithm for NIR modeling based on manifold learning].

    Science.gov (United States)

    Hong, Ming-Jian; Wen, Zhi-Yu; Zhang, Xiao-Hong; Wen, Quan

    2009-07-01

    Manifold learning is a new kind of algorithm originating from the field of machine learning to find the intrinsic dimensionality of numerous and complex data and to extract most important information from the raw data to develop a regression or classification model. The basic assumption of the manifold learning is that the high-dimensional data measured from the same object using some devices must reside on a manifold with much lower dimensions determined by a few properties of the object. While NIR spectra are characterized by their high dimensions and complicated band assignment, the authors may assume that the NIR spectra of the same kind of substances with different chemical concentrations should reside on a manifold with much lower dimensions determined by the concentrations, according to the above assumption. As one of the best known algorithms of manifold learning, locally linear embedding (LLE) further assumes that the underlying manifold is locally linear. So, every data point in the manifold should be a linear combination of its neighbors. Based on the above assumptions, the present paper proposes a new algorithm named least square locally weighted regression (LS-LWR), which is a kind of LWR with weights determined by the least squares instead of a predefined function. Then, the NIR spectra of glucose solutions with various concentrations are measured using a NIR spectrometer and LS-LWR is verified by predicting the concentrations of glucose solutions quantitatively. Compared with the existing algorithms such as principal component regression (PCR) and partial least squares regression (PLSR), the LS-LWR has better predictability measured by the standard error of prediction (SEP) and generates an elegant model with good stability and efficiency.

  7. Preclinical evaluation of near-infrared (NIR) fluorescently labeled cetuximab as a potential tool for fluorescence-guided surgery.

    Science.gov (United States)

    Saccomano, Mara; Dullin, Christian; Alves, Frauke; Napp, Joanna

    2016-11-15

    The high rate of recurrence in patients with pancreatic ductal adenocarcinoma (PDAC) could be reduced by supporting the surgeons in discriminating healthy from diseased tissues with intraoperative fluorescence-guidance. Here, we studied the suitability of Cetuximab, a therapeutic monoclonal antibody targeting the human epidermal growth factor receptor (EGFR), near-infrared (NIR) fluorescently labeled as a new tool for fluorescence-guided surgery. Distribution and binding of systemically injected Cetuximab Alexa Fluor 647 conjugate (Cetux-Alexa-647) and the co-injected control human IgG Alexa Fluor 750 conjugate (hIgG-Alexa-750) was studied over 48 h by NIR fluorescence imaging in mice bearing human orthotopic AsPC-1 and MIA PaCa-2 PDAC tumors. Cetux-Alexa-647, but not the control hIgG-Alexa-750 fluorescence, was specifically detected in vivo in both primary pancreatic tumors with maximum fluorescence intensities at 24 h, and in metastases of AsPC-1 tumors as small as 1 mm. Lifetime analysis and NIR fluorescence microscopy of tumor sections confirmed the binding specificity of Cetux-Alexa-647 to PDAC cells. Comparable results were obtained with Cetuximab conjugated to Alexa Fluor 750 dye (Cetux-Alexa-750). Fluorescence-guided dissection, performed 24 h after injection of Cetuximab conjugated to IRDye 800CW (Cetux-800CW), enabled a real-time delineation of AsPC-1 tumor margins, and small metastases. Odyssey scans revealed that only the vital part of the tumor, but not the necrotic part was stained with Cetux-800CW. NIR fluorescently labeled Cetuximab may be a promising tool that can be applied for fluorescence-guided surgery to visualize tumor margins and metastatic sites in order to allow a precise surgical resection.

  8. GSH-Activated NIR Fluorescent Prodrug for Podophyllotoxin Delivery.

    Science.gov (United States)

    Liu, Yajing; Zhu, Shaojia; Gu, Kaizhi; Guo, Zhiqian; Huang, Xiaoyu; Wang, Mingwei; Amin, Hesham M; Zhu, Weihong; Shi, Ping

    2017-09-06

    Theranostic prodrug therapy enables the targeted delivery of anticancer drugs with minimized adverse effects and real-time in situ monitoring of activation of the prodrugs. In this work, we report the synthesis and biological assessment of the near-infrared (NIR) prodrug DCM-S-PPT and its amphiphilic copolymer (mPEG-DSPE)-encapsulated nanoparticles. DCM-S-PPT is composed of podophyllotoxin (PPT) as the anticancer moiety and a dicyanomethylene-4H-pyran (DCM) derivative as the NIR fluorescent reporter, which are linked by a thiol-specific cleavable disulfide bond. In vitro experiments indicated that DCM-S-PPT has low cytotoxicity and that glutathione (GSH) can activate DCM-S-PPT resulting in PPT release and a concomitant significant enhancement in NIR fluorescence at 665 nm. After being intravenously injected into tumor-bearing nude mice, DCM-S-PPT exhibited excellent tumor-activated performance. Furthermore, we have demonstrated that mPEG-DSPE as a nanocarrier loaded with DCM-S-PPT (mPEG-DSPE/DCM-S-PPT) showed even greater tumor-targeting performance than DCM-S-PPT on account of the enhanced permeability and retention effect. Its tumor-targeting ability and specific drug release in tumors make DCM-S-PPT a promising prodrug that could provide a significant strategy for theranostic drug delivery systems.

  9. White Asparagus Harvest Date Discrimination Using Nirs Technology

    Science.gov (United States)

    Jarén, C.; Arazuri, S.; García, M. J.; Arnal, P.; Arana, J. I.

    2006-03-01

    Asparagus is still an important resource for mid-size and small farms. It has been traditionally believed that factors such as the asparagus harvesting date have an influence on its quality. This research sought to identify the harvesting dates of different fruits by using Near Infrared Spectroscopy (NIRS) technology as quality indicators and the best zone a long of the asparagus to acquire the spectrum. All the asparagus tested came from the same manufacturer but had been canned on three different dates, giving a total of nine lots. There were one hundred asparagus per lot and the experiment data were taken from three different parts (tip, middle, and base) of each spear. Reflectance spectrum in the near infrared between 800 1700 nm was determined. Differences NIRS among the asparagus harvested on different dates were found. NIRS technology was able to classify the asparagus correctly in terms of harvest dates (71% well classified). The base of the asparagus turned out to be the best part to use in order to establish the harvest date.

  10. The application of near infrared spectroscopy (NIR technique for

    Directory of Open Access Journals (Sweden)

    Sandor Barabassy

    2001-06-01

    Full Text Available The production of cow’s milk in Hungary fluctuates by 15-20 % annualy. Surplus milk is dried into powder and can also be converted to modified milk powders using techniques such as ultra filtration. From approximetely 20.000 tonnes, of all milk powder types, 3.000 tonnes, is converted using ultra filtration technology. Multivariable near infrared (NIR calibration was performed on powder mixtures of whole milk, skimmed milk, whey, retenate (protein concentrate and lactose for rapid fat, protein, lactose, water and ash content determination. More than 150 samples were prepared and measured in two NIRS labs (Scottish Agriculture College – SAC – Aberdeen and University of Horticulture and Food Science - UHFS – Budapest. The results obtained from the same samples were compared. The aims of the study were: 1. Rapid quantitative and qualitative determination of mixtures of milk powder products using NIR technique. 2. Comparison of the results achieved in Aberdeen (SAC and Budapest (UHFS institutes. The mass per cent varied between 0.0-2.8% for fat, 0.0-80% for protein, 6.6-100 % for lactose, 0.0-5.0 % for water and 0.0-8.0 % for ash. High correlation coefficients (0.97-0.99 were found for all five components.

  11. UV-VIS-NIR spectroscopy and microscopy of heterogeneous catalysts.

    Science.gov (United States)

    Schoonheydt, Robert A

    2010-12-01

    This critical review article discusses the characterization of heterogeneous catalysts by UV-VIS-NIR spectroscopy and microscopy with special emphasis on transition metal ion containing catalysts. A review is given of the transitions, that can be observed in the UV-VIS-NIR region and the peculiarities of catalytic solids that have to be taken into account. This is followed by a short discussion of the techniques that have been developed over the years: diffuse reflectance spectroscopy, UV-VIS microscopy, in situ or operando spectroscopy, the combination of UV-VIS spectroscopy with other spectroscopic techniques, with chemometrics and with quantum chemistry. In the third part of this paper four successes of UV-VIS-NIR spectroscopy and microscopy are discussed; (1) coordination of transition metal ions to surface oxygens; (2) quantitative determination of the oxidation states of transition metal ions; (3) characterization of active sites and (4) study of the distribution of transition metal ions and carbocations in catalytic bodies, particles and crystals (104 references).

  12. Facile Peptides Functionalization of Lanthanide-Based Nanocrystals through Phosphorylation Tethering for Efficient in Vivo NIR-to-NIR Bioimaging.

    Science.gov (United States)

    Yao, Chi; Wang, Peiyuan; Wang, Rui; Zhou, Lei; El-Toni, Ahmed Mohamed; Lu, Yiqing; Li, Xiaomin; Zhang, Fan

    2016-02-02

    Peptide modification of nanoparticles is a challenging task for bioapplications. Here, we show that noncovalent surface engineering based on ligand exchange of peptides for lanthanide based upconversion and downconversion near-infrared (NIR) luminescent nanoparticles can be efficiently realized by modifying the hydroxyl functional group of a side grafted serine of peptides into a phosphate group (phosphorylation). By using the phosphorylated peptide with the arginine-glycine-aspartic acid (RGD) targeting motifs as typical examples, the modification allows improving the selectivity, sensitivity, and signal-to-noise ratio for the cancer targeting and bioimaging and reducing the toxicity derived from nonspecific interactions of nanoparticles with cells. The in vivo NIR bioimaging signal could even be detected at low injection amounts down to 20 μg per animal.

  13. Foss Italia. NIR spectroscopy for foods quality; Foss Italia. Qualita' negli alimenti con spettroscopia NIR

    Energy Technology Data Exchange (ETDEWEB)

    Cianflone, F. [Foss Electric Italia SpA, Este, PD (Italy)

    2000-10-01

    The Italian subsidiary of the Danish Foss Electric distributes in Italy sophisticated equipment for humidity measurement in corn, in proteins, in milk glucides and lipids, and in many other foodstuffs. Analysis are reliable and very fast, workable also in other industrial sectors and in pharmaceutical labs. Measurement technique, non destructive, is NIR spectroscopy. [Italian] La filiale italiana di un'azienda internazionale, la danese Foss Electric, commercializza nel nostro Paese sofisticate apparecchiature per la determinazione dell'umidita' nei cereali, delle proteine, dei glucidi e dei lipidi nel latte, nelle graminacee e in molte altre derrate. Le analisi sono affidabili e molto rapide, eseguibili anche in altri comparti industriali e farmaceutici. La tecnica di misura, non distruttiva, e' quella della spettroscopia nel vicino infrarosso (NIR).

  14. Physical properties of highly uniform InGaAs pyramidal quantum dots with GaAs barriers: Fine structure splitting in pre-patterned substrates

    OpenAIRE

    Mereni, L. O.; Mereni, E. Pelucchia L. O.; Dimastrodonatoa, V.; Juskaa, G.; Pelucchi, E.

    2011-01-01

    InGaAs Quantum Dots embedded in GaAs barriers, grown in inverted tetrahedral recesses of 7 {\\mu}m edge, have showed interesting characteristics in terms of uniformity and spectral narrowness of the emission. In this paper we present a study on the fine structure splitting (FSS). The investigation of about 40 single quantum dots revealed two main points: (1) the values of this parameter are very similar from dot to dot, proving again the uniformity of Pyramidal QD properties, (2) there is a li...

  15. nirS-Encoding denitrifier community composition, distribution, and abundance along the coastal wetlands of China.

    Science.gov (United States)

    Gao, Juan; Hou, Lijun; Zheng, Yanling; Liu, Min; Yin, Guoyu; Li, Xiaofei; Lin, Xianbiao; Yu, Chendi; Wang, Rong; Jiang, Xiaofen; Sun, Xiuru

    2016-10-01

    For the past few decades, human activities have intensively increased the reactive nitrogen enrichment in China's coastal wetlands. Although denitrification is a critical pathway of nitrogen removal, the understanding of denitrifier community dynamics driving denitrification remains limited in the coastal wetlands. In this study, the diversity, abundance, and community composition of nirS-encoding denitrifiers were analyzed to reveal their variations in China's coastal wetlands. Diverse nirS sequences were obtained and more than 98 % of them shared considerable phylogenetic similarity with sequences obtained from aquatic systems (marine/estuarine/coastal sediments and hypoxia sea water). Clone library analysis revealed that the distribution and composition of nirS-harboring denitrifiers had a significant latitudinal differentiation, but without a seasonal shift. Canonical correspondence analysis showed that the community structure of nirS-encoding denitrifiers was significantly related to temperature and ammonium concentration. The nirS gene abundance ranged from 4.3 × 10(5) to 3.7 × 10(7) copies g(-1) dry sediment, with a significant spatial heterogeneity. Among all detected environmental factors, temperature was a key factor affecting not only the nirS gene abundance but also the community structure of nirS-type denitrifiers. Overall, this study significantly enhances our understanding of the structure and dynamics of denitrifying communities in the coastal wetlands of China.

  16. Vis-NIR Spectroscopy of Mineral Mixtures with Montmorillonite and Silica: Implications for Detecting Alteration Products on Mars

    Science.gov (United States)

    Rampe, E. B.; Kraft, M. D.; Sharp, T. G.

    2009-12-01

    Introduction. A variety of secondary silicates have been identified on Mars using Vis-NIR spectroscopic data from the Observatoire pour la Mineralogie, l’Eau, les Glaces et l’Activite (OMEGA) on Mars Express and the Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) on Mars Reconnaissance Orbiter, including smectite, chlorite, kaolinite, and illite clay minerals and hydrous amorphous silica [1-4]. The detection of these materials is significant because they provide important information about past aqueous environments on Mars. Vis-NIR spectra of specific secondary silicates can be distinguished by the positions and shapes of hydration features. Here, we investigate the detection of secondary silicates by vis-NIR spectroscopy of mixtures with basaltic igneous minerals and either hydrous amorphous silica or montmorillonite. Experimental Procedure. Minor amounts of clay (2.5, 5, 10, and 20 wt%) were physically mixed with augite, andesine, or olivine (75-106 μm). A portion of each mixture was compressed into a pellet. Vis-NIR spectra (0.32-2.55 μm) of particulate and pellet mixtures were measured at RELAB at Brown University, and each spectrum was visually inspected to determine detection limits of secondary silicates based on hydration features. Preliminary Results. Absorptions at 1.4 and 1.9 μm (OH stretch overtone and H2O bend and stretch, respectively) occur in almost all mixture spectra; however, the strength, shape, and position are dependent on the igneous mineral and secondary silicate abundance in the mixture. The morphology of absorptions at ~2.2 μm (from metal-OH bonds) differs between amorphous silica and montmorillonite [3,4], so we use these absorptions to determine the detection limits of amorphous silica and montmorillonite. The 2.2 μm absorption is present in all montmorillonite-mixture spectra, indicating the montmorillonite detection limit is 10 wt% silica. Conclusions. Vis-NIR spectra of our mineral mixtures show that

  17. Plasmonic field confinement for separate absorption-multiplication in InGaAs nanopillar avalanche photodiodes

    Science.gov (United States)

    Farrell, Alan C.; Senanayake, Pradeep; Hung, Chung-Hong; El-Howayek, Georges; Rajagopal, Abhejit; Currie, Marc; Hayat, Majeed M.; Huffaker, Diana L.

    2015-12-01

    Avalanche photodiodes (APDs) are essential components in quantum key distribution systems and active imaging systems requiring both ultrafast response time to measure photon time of flight and high gain to detect low photon flux. The internal gain of an APD can improve system signal-to-noise ratio (SNR). Excess noise is typically kept low through the selection of material with intrinsically low excess noise, using separate-absorption-multiplication (SAM) heterostructures, or taking advantage of the dead-space effect using thin multiplication regions. In this work we demonstrate the first measurement of excess noise and gain-bandwidth product in III-V nanopillars exhibiting substantially lower excess noise factors compared to bulk and gain-bandwidth products greater than 200 GHz. The nanopillar optical antenna avalanche detector (NOAAD) architecture is utilized for spatially separating the absorption region from the avalanche region via the NOA resulting in single carrier injection without the use of a traditional SAM heterostructure.

  18. Plasmonic field confinement for separate absorption-multiplication in InGaAs nanopillar avalanche photodiodes.

    Science.gov (United States)

    Farrell, Alan C; Senanayake, Pradeep; Hung, Chung-Hong; El-Howayek, Georges; Rajagopal, Abhejit; Currie, Marc; Hayat, Majeed M; Huffaker, Diana L

    2015-12-02

    Avalanche photodiodes (APDs) are essential components in quantum key distribution systems and active imaging systems requiring both ultrafast response time to measure photon time of flight and high gain to detect low photon flux. The internal gain of an APD can improve system signal-to-noise ratio (SNR). Excess noise is typically kept low through the selection of material with intrinsically low excess noise, using separate-absorption-multiplication (SAM) heterostructures, or taking advantage of the dead-space effect using thin multiplication regions. In this work we demonstrate the first measurement of excess noise and gain-bandwidth product in III-V nanopillars exhibiting substantially lower excess noise factors compared to bulk and gain-bandwidth products greater than 200 GHz. The nanopillar optical antenna avalanche detector (NOAAD) architecture is utilized for spatially separating the absorption region from the avalanche region via the NOA resulting in single carrier injection without the use of a traditional SAM heterostructure.

  19. An Exploration of the Effect of Hemodynamic Changes Due to Normal Aging on the fNIRS Response to Semantic Processing of Words.

    Science.gov (United States)

    Amiri, Mahnoush; Pouliot, Philippe; Bonnéry, Clément; Leclerc, Paul-Olivier; Desjardins, Michèle; Lesage, Frédéric; Joanette, Yves

    2014-01-01

    Like other neuroimaging techniques assessing cerebral blood oxygenation, near-infrared spectroscopy (NIRS) has been applied in many neurocognitive studies. With NIRS, neural activation can be explored indirectly via hemodynamic changes in the imaged region. In studies of aging, changes in baseline physiology and brain anatomy confound NIRS measures seeking to investigate age-related changes in neuronal activity. The field is thus hampered by the complexity of the aging process itself, and statistical inferences from functional data acquired by optical imaging techniques must be interpreted with care. Multimodal integration of NIRS with both structural and baseline physiological assessments is crucial to avoid misinterpreting neuroimaging signals. In this study, a combination of two different optical techniques, anatomical MRI and Arterial Spin Labeling (ASL), was used to investigate age-related changes in activation during a lexical-semantic processing task. Quantitative analysis revealed decreased baseline oxyhemoglobin and cerebral blood flow in the older adults. Using baseline physiology measures as regressors in the investigation of functional concentration changes when doing analyses of variance, we found significant changes in task-induced areas of activity. In the right hemisphere, more significant age-related activity was observed around the junction of the inferior frontal gyrus and inferior precentral sulcus, along with engagement of Wernicke's area. In the left hemisphere, the degree and extent of frontal activation, including the dorsolateral prefrontal cortex and inferior frontal gyrus, differed between age groups. Measuring background physiological differences and using their values as regressors in statistical analyses allowed a more appropriate, age-corrected understanding of the functional differentiations between age groups. Age-corrected baselines are thus essential to investigate which components of the NIRS signal are altered by aging.

  20. Spoof Detection for Finger-Vein Recognition System Using NIR Camera

    Directory of Open Access Journals (Sweden)

    Dat Tien Nguyen

    2017-10-01

    Full Text Available Finger-vein recognition, a new and advanced biometrics recognition method, is attracting the attention of researchers because of its advantages such as high recognition performance and lesser likelihood of theft and inaccuracies occurring on account of skin condition defects. However, as reported by previous researchers, it is possible to attack a finger-vein recognition system by using presentation attack (fake finger-vein images. As a result, spoof detection, named as presentation attack detection (PAD, is necessary in such recognition systems. Previous attempts to establish PAD methods primarily focused on designing feature extractors by hand (handcrafted feature extractor based on the observations of the researchers about the difference between real (live and presentation attack finger-vein images. Therefore, the detection performance was limited. Recently, the deep learning framework has been successfully applied in computer vision and delivered superior results compared to traditional handcrafted methods on various computer vision applications such as image-based face recognition, gender recognition and image classification. In this paper, we propose a PAD method for near-infrared (NIR camera-based finger-vein recognition system using convolutional neural network (CNN to enhance the detection ability of previous handcrafted methods. Using the CNN method, we can derive a more suitable feature extractor for PAD than the other handcrafted methods using a training procedure. We further process the extracted image features to enhance the presentation attack finger-vein image detection ability of the CNN method using principal component analysis method (PCA for dimensionality reduction of feature space and support vector machine (SVM for classification. Through extensive experimental results, we confirm that our proposed method is adequate for presentation attack finger-vein image detection and it can deliver superior detection results compared

  1. Wearable functional Near Infrared Spectroscopy (fNIRS and transcranial Direct Current Stimulation (tDCS: Expanding Vistas for Neurocognitive Augmentation

    Directory of Open Access Journals (Sweden)

    Ryan eMcKendrick

    2015-03-01

    Full Text Available Contemporary studies with transcranial direct current stimulation (tDCS provide a growing base of evidence for enhancing cognition through the non-invasive delivery of weak electric currents to the brain. The main effect of tDCS is to modulate cortical excitability depending on the polarity of the applied current. However, the underlying mechanism of neuromodulation is not well understood. A new generation of functional near infrared spectroscopy (fNIRS systems is described that are miniaturized, portable, and include wearable sensors. These developments provide an opportunity to couple fNIRS with tDCS, consistent with a neuroergonomics approach for joint neuroimaging and neurostimulation investigations of cognition in complex tasks and in naturalistic conditions. The effects of tDCS on complex task performance and the use of fNIRS for monitoring cognitive workload during task performance are described. Also explained is how fNIRS + tDCS can be used simultaneously for assessing spatial working memory. Mobile optical brain imaging is a promising neuroimaging tool that has the potential to complement tDCS for realistic applications in natural settings.

  2. Color Restoration of RGBN Multispectral Filter Array Sensor Images Based on Spectral Decomposition.

    Science.gov (United States)

    Park, Chulhee; Kang, Moon Gi

    2016-05-18

    A multispectral filter array (MSFA) image sensor with red, green, blue and near-infrared (NIR) filters is useful for various imaging applications with the advantages that it obtains color information and NIR information simultaneously. Because the MSFA image sensor needs to acquire invisible band information, it is necessary to remove the IR cut-offfilter (IRCF). However, without the IRCF, the color of the image is desaturated by the interference of the additional NIR component of each RGB color channel. To overcome color degradation, a signal processing approach is required to restore natural color by removing the unwanted NIR contribution to the RGB color channels while the additional NIR information remains in the N channel. Thus, in this paper, we propose a color restoration method for an imaging system based on the MSFA image sensor with RGBN filters. To remove the unnecessary NIR component in each RGB color channel, spectral estimation and spectral decomposition are performed based on the spectral characteristics of the MSFA sensor. The proposed color restoration method estimates the spectral intensity in NIR band and recovers hue and color saturation by decomposing the visible band component and the NIR band component in each RGB color channel. The experimental results show that the proposed method effectively restores natural color and minimizes angular errors.

  3. Image Fusion Techniques for Multispectral Palm Image Enhancement

    OpenAIRE

    Rajashree Bhokare; Deepali Sale; Dr. (Mrs. ) M. A. Joshi; Dr. M. S. Gaikwad

    2013-01-01

    We proposed the multispectral image enhancement through image fusion by combining the data from the multiple spectrum to address the problem of accuracy and make the system robust against spoofing and to improve the accuracy of recognition, using more discriminating of palm images. Palm line features are clearer in the blue and green bands while red band can reveal some palm vein structure. The NIR band can show the palm vein structure as well as partial line information. Image fusion improve...

  4. Bio-imaging of colorectal cancer models using near infrared labeled epidermal growth factor.

    Directory of Open Access Journals (Sweden)

    Gadi Cohen

    Full Text Available Novel strategies that target the epidermal growth factor receptor (EGFR have led to the clinical development of monoclonal antibodies, which treat metastatic colorectal cancer (mCRC but only subgroups of patients with increased wild type KRAS and EGFR gene copy, respond to these agents. Furthermore, resistance to EGFR blockade inevitably occurred, making future therapy difficult. Novel bio-imaging (BOI methods may assist in quantization of EGFR in mCRC tissue thus complementing the immunohistochemistry methodology, in guiding the future treatment of these patients. The aim of the present study was to explore the usefulness of near infrared-labeled EGF (EGF-NIR for bio-imaging of CRC using in vitro and in vivo orthotopic tumor CRC models and ex vivo human CRC tissues. We describe the preparation and characterization of EGF-NIR and investigate binding, using BOI of a panel of CRC cell culture models resembling heterogeneity of human CRC tissues. EGF-NIR was specifically and selectively bound by EGFR expressing CRC cells, the intensity of EGF-NIR signal to background ratio (SBR reflected EGFR levels, dose-response and time course imaging experiments provided optimal conditions for quantization of EGFR levels by BOI. EGF-NIR imaging of mice with HT-29 orthotopic CRC tumor indicated that EGF-NIR is more slowly cleared from the tumor and the highest SBR between tumor and normal adjacent tissue was achieved two days post-injection. Furthermore, images of dissected tissues demonstrated accumulation of EGF-NIR in the tumor and liver. EGF-NIR specifically and strongly labeled EGFR positive human CRC tissues while adjacent CRC tissue and EGFR negative tissues expressed weak NIR signals. This study emphasizes the use of EGF-NIR for preclinical studies. Combined with other methods, EGF-NIR could provide an additional bio-imaging specific tool in the standardization of measurements of EGFR expression in CRC tissues.

  5. Hyperspectral Imaging of Functional Patterns for Disease Assessment and Treatment Monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Demos, S; Hattery, D; Hassan, M; Aleman, K; Little, R; Yarchoan, R; Gandjbakhche, A

    2003-12-05

    We have designed and built a six-band multi-spectral NIR imaging system used in clinical testing on cancer patients. From our layered tissue model, we create blood volume and blood oxygenation images for patient treatment monitoring.

  6. NIR-LEDs lighting system for enhancing Brix distinction with saving energy to agricultural products

    Science.gov (United States)

    Lee, Kwang-Hoon; Lee, Dong-Kil; Kim, Yang-Gyu; Park, Ahn-Jin; Jang, Won-Geun; Park, Youngsik

    2014-05-01

    In this paper, the sugar content prediction determination system in optical non-contact type based on the near infrared light emitting diode (NIR-LED) lamp is proposed. As the result NIR-LED lamp reduced 86% of the energy consumption compared to the case of Halogen lamp in the same process of sugar content determination. And the result of prediction of sugar content by NIR-LED lamp is shown to as near the same level of Halogen lamp system.

  7. Growing InGaAs quasi-quantum wires inside semi-rhombic shaped planar InP nanowires on exact (001) silicon

    Science.gov (United States)

    Han, Yu; Li, Qiang; Chang, Shih-Pang; Hsu, Wen-Da; Lau, Kei May

    2016-06-01

    We report InGaAs quasi-quantum wires embedded in planar InP nanowires grown on (001) silicon emitting in the 1550 nm communication band. An array of highly ordered InP nanowire with semi-rhombic cross-section was obtained in pre-defined silicon V-grooves through selective-area hetero-epitaxy. The 8% lattice mismatch between InP and Si was accommodated by an ultra-thin stacking disordered InP/GaAs nucleation layer. X-ray diffraction and transmission electron microscope characterizations suggest excellent crystalline quality of the nanowires. By exploiting the morphological evolution of the InP and a self-limiting growth process in the V-grooves, we grew embedded InGaAs quantum-wells and quasi-quantum-wires with tunable shape and position. Room temperature analysis reveals substantially improved photoluminescence in the quasi-quantum wires as compared to the quantum-well reference, due to the reduced intrusion defects and enhanced quantum confinement. These results show great promise for integration of III-V based long wavelength nanowire lasers on the well-established (001) Si platform.

  8. Investigation of electrically active defects in InGaAs quantum wire intermediate-band solar cells using deep-level transient spectroscopy technique

    Science.gov (United States)

    Saqri, Noor alhuda Al; Felix, Jorlandio F.; Aziz, Mohsin; Kunets, Vasyl P.; Jameel, Dler; Taylor, David; Henini, Mohamed; Abd El-sadek, Mahmmoud S.; Furrow, Colin; Ware, Morgan E.; Benamara, Mourad; Mortazavi, Mansour; Salamo, Gregory

    2017-01-01

    InGaAs quantum wire (QWr) intermediate-band solar cell-based nanostructures grown by molecular beam epitaxy are studied. The electrical and interface properties of these solar cell devices, as determined by current-voltage (I-V) and capacitance-voltage (C-V) techniques, were found to change with temperature over a wide range of 20-340 K. The electron and hole traps present in these devices have been investigated using deep-level transient spectroscopy (DLTS). The DLTS results showed that the traps detected in the QWr-doped devices are directly or indirectly related to the insertion of the Si δ-layer used to dope the wires. In addition, in the QWr-doped devices, the decrease of the solar conversion efficiencies at low temperatures and the associated decrease of the integrated external quantum efficiency through InGaAs could be attributed to detected traps E1QWR_D, E2QWR_D, and E3QWR_D with activation energies of 0.0037, 0.0053, and 0.041 eV, respectively.

  9. Comparison of different grading schemes in InGaAs metamorphic buffers on GaAs substrate: Tilt dependence on cross-hatch irregularities

    Science.gov (United States)

    Kumar, Rahul; Bag, Ankush; Mukhopadhyay, Partha; Das, Subhashis; Biswas, Dhrubes

    2015-12-01

    InGaAs graded metamorphic buffers (MBs) with different grading strategies have been grown by molecular beam epitaxy (MBE) on GaAs (0 0 1) substrate. A detailed comparative analysis of surface using atomic force microscopy (AFM), and bulk properties using high resolution X-ray diffraction (HRXRD) and room temperature photoluminescence (RTPL) of grown MBs have been presented to comprehend the effectiveness of different grading scheme on InGaAs MBs. Conventional, statistical and fractal analysis on measured AFM data has been performed for in-depth investigation of these surfaces. The grading scheme has been found to have little impact on residual strain while it affects the epitaxial tilt significantly. Moreover, the tilt has been found to depend on growth front irregularities. Tilt magnitude in a graded MB has been found to vary with composition while tilt azimuth has been found to be almost same in the graded layers. PL Intensity and a shift in the PL peaks have been used to study the quality of the MB and residual strain comparatively.

  10. Investigation of electrically active defects in InGaAs quantum wire intermediate-band solar cells using deep-level transient spectroscopy technique.

    Science.gov (United States)

    Al Saqri, Noor Alhuda; Felix, Jorlandio F; Aziz, Mohsin; Kunets, Vasyl P; Jameel, Dler; Taylor, David; Henini, Mohamed; Abd El-Sadek, Mahmmoud S; Furrow, Colin; Ware, Morgan E; Benamara, Mourad; Mortazavi, Mansour; Salamo, Gregory

    2017-01-27

    InGaAs quantum wire (QWr) intermediate-band solar cell-based nanostructures grown by molecular beam epitaxy are studied. The electrical and interface properties of these solar cell devices, as determined by current-voltage (I-V) and capacitance-voltage (C-V) techniques, were found to change with temperature over a wide range of 20-340 K. The electron and hole traps present in these devices have been investigated using deep-level transient spectroscopy (DLTS). The DLTS results showed that the traps detected in the QWr-doped devices are directly or indirectly related to the insertion of the Si δ-layer used to dope the wires. In addition, in the QWr-doped devices, the decrease of the solar conversion efficiencies at low temperatures and the associated decrease of the integrated external quantum efficiency through InGaAs could be attributed to detected traps E1QWR_D, E2QWR_D, and E3QWR_D with activation energies of 0.0037, 0.0053, and 0.041 eV, respectively.

  11. Initial Processes of Atomic Layer Deposition of Al2O3 on InGaAs: Interface Formation Mechanisms and Impact on Metal-Insulator-Semiconductor Device Performance

    Directory of Open Access Journals (Sweden)

    Shinichi Takagi

    2012-03-01

    Full Text Available Interface-formation processes in atomic layer deposition (ALD of Al2O3 on InGaAs surfaces were investigated using on-line Auger electron spectroscopy. Al2O3 ALD was carried out by repeating a cycle of Al(CH33 (trimethylaluminum, TMA adsorption and oxidation by H2O. The first two ALD cycles increased the Al KLL signal, whereas they did not increase the O KLL signal. Al2O3 bulk-film growth started from the third cycle. These observations indicated that the Al2O3/InGaAs interface was formed by reduction of the surface oxides with TMA. In order to investigate the effect of surface-oxide reduction on metal-insulator-semiconductor (MIS properties, capacitors and field-effect transistors (FETs were fabricated by changing the TMA dosage during the interface formation stage. The frequency dispersion of the capacitance-voltage characteristics was reduced by employing a high TMA dosage. The high TMA dosage, however, induced fixed negative charges at the MIS interface and degraded channel mobility.

  12. Image Monitoring of Pharmaceutical Blending Processes and the Determination of an End Point by Using a Portable Near-Infrared Imaging Device Based on a Polychromator-Type Near-Infrared Spectrometer with a High-speed and High-Resolution Photo Diode Array Detector

    Directory of Open Access Journals (Sweden)

    Kodai Murayama

    2015-03-01

    Full Text Available In the present study we have developed a new version (ND-NIRs of a polychromator-type near-infrared (NIR spectrometer with a high-resolution photo diode array detector, which we built before (D-NIRs. The new version has four 5 W halogen lamps compared with the three lamps for the older version. The new version also has a condenser lens with a shorter focal point length. The increase in the number of the lamps and the shortening of the focal point of the condenser lens realize high signal-to-noise ratio and high-speed NIR imaging measurement. By using the ND-NIRs we carried out the in-line monitoring of pharmaceutical blending and determined an end point of the blending process. Moreover, to determinate a more accurate end point, a NIR image of the blending sample was acquired by means of a portable NIR imaging device based on ND-NIRs. The imaging result has demonstrated that the mixing time of 8 min is enough for homogeneous mixing. In this way the present study has demonstrated that ND-NIRs and the imaging system based on a ND-NIRs hold considerable promise for process analysis.

  13. NIR reflectance method to determine moisture content in food products

    Science.gov (United States)

    Kandala, C. V. K.; Konda Naganathan, G.; Subbiah, J.

    2008-08-01

    Moisture content (MC) is an important quality factor that is measured and monitored, at various stages of processing and storage, in the food industry. There are some commercial instruments available that use near infrared (NIR) radiation measurements to determine the moisture content of a variety of grain products, such as wheat and corn, with out the need of any sample grinding or preparation. However, to measure the MC of peanuts with these instruments the peanut kernels have to be chopped into smaller pieces and filled into the measuring cell. This is cumbersome, time consuming and destructive. An NIR reflectance method is presented here by which the average MC of about 100 g of whole kernels could be determined rapidly and nondestructively. The MC range of the peanut kernels tested was between 8% and 26%. Initially, NIR reflectance measurements were made at 1 nm intervals in the wave length range of 1000 nm to 1800 nm and the data was modeled using partial least squares regression (PLSR). The predicted values of the samples tested in the above range were compared with the values determined by the standard air-oven method. The predicted values agreed well with the air-oven values with an R2 value of 0.96 and a standard error of prediction (SEP) of 0.83. Using the PLSR beta coefficients, five key wavelengths were identified and using multiple linear regression (MLR) method MC predictions were made. The R2 and SEP values of the MLR model were 0.84 and 1.62, respectively. Both methods performed satisfactorily and being rapid, nondestructive, and non-contact, may be suitable for continuous monitoring of MC of grain and peanuts as they move on conveyor belts during their processing.

  14. New NIR Calibration Models Speed Biomass Composition and Reactivity Characterization

    Energy Technology Data Exchange (ETDEWEB)

    2015-09-01

    Obtaining accurate chemical composition and reactivity (measures of carbohydrate release and yield) information for biomass feedstocks in a timely manner is necessary for the commercialization of biofuels. This highlight describes NREL's work to use near-infrared (NIR) spectroscopy and partial least squares multivariate analysis to develop calibration models to predict the feedstock composition and the release and yield of soluble carbohydrates generated by a bench-scale dilute acid pretreatment and enzymatic hydrolysis assay. This highlight is being developed for the September 2015 Alliance S&T Board meeting.

  15. [Visible-NIR spectral feature of citrus greening disease].

    Science.gov (United States)

    Li, Xiu-hua; Li, Min-zan; Won Suk, Lee; Reza, Ehsani; Ashish, Ratn Mishra

    2014-06-01

    Citrus greening (Huanglongbing, or HLB) is a devastating disease caused by Candidatus liberibacter which uses psyllids as vectors. It has no cure till now, and poses a huge threat to citrus industry around the world. In order to diagnose, assess and further control this disease, it is of great importance to first find a quick and effective way to detect it. Spectroscopy method, which was widely considered as a fast and nondestructive way, was adopted here to conduct a preliminary exploration of disease characteristics. In order to explore the spectral differences between the healthy and HLB infected leaves and canopies, this study measured the visible-NIR spectral reflectance of their leaves and canopies under lab and field conditions, respectively. The original spectral data were firstly preprocessed with smoothing (or moving average) and cluster average procedures, and then the first derivatives were also calculated to determine the red edge position (REP). In order to solve the multi-peak phenomenon problem, two interpolation methods (three-point Lagrangian interpolation and four-point linear extrapolation) were adopted to calculate the REP for each sample. The results showed that there were, obvious differences at the visible & NIR spectral reflectance between the healthy and HLB infected classes. Comparing with the healthy reflectance, the HLB reflectance was higher at the visible bands because of the yellowish symptoms on the infected leaves, and lower at NIR bands because the disease blocked water transportation to leaves. But the feature at NIR bands was easily affected by environmental factors such as light, background, etc. The REP was also a potential indicator to distinguish those two classes. The average REP was slowly moving toward red bands while the infection level was getting higher. The gap of the average REPs between the healthy and HLB classes reached to a maximum of 20 nm. Even in the dataset with relatively lower variation, the classification

  16. Detection of Honey Adulteration using Hyperspectral Imaging

    NARCIS (Netherlands)

    Shafiee, Sahameh; Polder, Gerrit; Minaei, Saeid; Moghadam-charkari, Nasrolah; Ruth, Van Saskia; Kuś, Piotr M.

    2016-01-01

    This study investigates the application of hyperspectral imaging system and data mining based classifiers for honey adulteration detection. Hyperspectral images from pure and adulterated samples were captured in using a VIS-NIR hyperspectral camera (400 – 1000 nm). After preprocessing the images, fi

  17. Detection of Honey Adulteration using Hyperspectral Imaging

    NARCIS (Netherlands)

    Shafiee, Sahameh; Polder, Gerrit; Minaei, Saeid; Moghadam-charkari, Nasrolah; Ruth, Van Saskia; Kuś, Piotr M.

    2016-01-01

    This study investigates the application of hyperspectral imaging system and data mining based classifiers for honey adulteration detection. Hyperspectral images from pure and adulterated samples were captured in using a VIS-NIR hyperspectral camera (400 – 1000 nm). After preprocessing the images,

  18. Fundamental examination of nanoparticle heating kinetics upon near infrared (NIR) irradiation.

    Science.gov (United States)

    Schrand, Amanda M; Stacy, Bradley M; Payne, Sarah; Dosser, Larry; Hussain, Saber M

    2011-10-01

    Near infrared (NIR) light, which spans wavelengths from ~700-1100 nm holds particular promise in bionanotechnology-enabled applications because both NIR light and nanoparticles (NPs) have the potential for remote activation leading to exquisite localization and targeting scenarios. In this study, aqueous solutions of carbon and metal-based NPs (carbon black, single-walled carbon nanotubes, silver nanoparticles and copper nanoparticles) were exposed to continuous NIR laser (λ = 1064 nm) irradiation at powers of 2.2W and 4.5W. The differential heating of bulk aqueous suspension of NPs with varying physicochemical properties revealed maximum temperatures of 67 °C with visible evidence of condensation and bubble formation. The basis of the NP heating is due to the strong intrinsic optical absorbance in the NIR spectral window and the transduction of this NIR photon energy into thermal energy. In this regard, UV-vis measurements can accurately predict NP heating kinetics prior to NIR irradiation. Further, a uniform thermodynamic heating model demonstrates close agreement with the experimental data for the low NIR-absorbing NPs. However, the uniform thermodynamic heating model used in this study does not accurately portray the energy release upon localized NP heating because of bubble formation for the highly absorbing NPs. Therefore, this study reveals the differential heating kinetics of NPs excited with NIR with implications in the development of novel NIR-NP-based systems.

  19. Transcriptional repressor NIR interacts with the p53-inhibiting ubiquitin ligase MDM2.

    Science.gov (United States)

    Heyne, Kristina; Förster, Juliane; Schüle, Roland; Roemer, Klaus

    2014-04-01

    NIR (novel INHAT repressor) can bind to p53 at promoters and inhibit p53-mediated gene transactivation by blocking histone acetylation carried out by p300/CBP. Like NIR, the E3 ubiquitin ligase MDM2 can also bind and inhibit p53 at promoters. Here, we present data indicating that NIR, which shuttles between the nucleolus and nucleoplasm, not only binds to p53 but also directly to MDM2, in part via the central acidic and zinc finger domain of MDM2 that is also contacted by several other nucleolus-based MDM2/p53-regulating proteins. Like some of these, NIR was able to inhibit the ubiquitination of MDM2 and stabilize MDM2; however, unlike these nucleolus-based MDM2 regulators, NIR did not inhibit MDM2 to activate p53. Rather, NIR cooperated with MDM2 to repress p53-induced transactivation. This cooperative repression may at least in part involve p300/CBP. We show that NIR can block the acetylation of p53 and MDM2. Non-acetylated p53 has been documented previously to more readily associate with inhibitory MDM2. NIR may thus help to sustain the inhibitory p53:MDM2 complex, and we present evidence suggesting that all three proteins can indeed form a ternary complex. In sum, our findings suggest that NIR can support MDM2 to suppress p53 as a transcriptional activator.

  20. Near-IR Atlas of S0-Sa galaxies (NIRS0S)

    CERN Document Server

    Laurikainen, E; Buta, R; Knapen, J H

    2011-01-01

    An atlas of Ks-band images of 206 early-type galaxies is presented, including 160 S0-S0/a galaxies, 12 ellipticals, and 33 Sa galaxies. A majority of the Atlas galaxies belong to a magnitude-limited (mB<12.5 mag) sample of 185 NIRS0S (Near-IR S0 galaxy Survey) galaxies. To assure that mis-classified S0s are not omitted, 25 ellipticals from RC3 classified as S0s in the Carnegie Atlas were included in the sample. The images are 2-3 mag deeper than 2MASS images. Both visual and photometric classifications are made. Special attention is paid to the classification of lenses, coded in a systematic manner. A new lens-type, called a 'barlens', is introduced. Also, boxy/peanut/x-shaped structures are identified in many barred galaxies, even-though the galaxies are not seen in edge-on view, indicating that vertical thickening is not enough to explain them. Multiple lenses appear in 25% of the Atlas galaxies, which is a challenge to the hierarchical evolutionary picture of galaxies. Such models need to explain how th...