Urban Market Gardening and Rodent-Borne Pathogenic Leptospira in Arid Zones: A Case Study in Niamey, Niger.

Science.gov (United States)

Dobigny, Gauthier; Garba, Madougou; Tatard, Caroline; Loiseau, Anne; Galan, Max; Kadaouré, Ibrahima; Rossi, Jean-Pierre; Picardeau, Mathieu; Bertherat, Eric

2015-01-01

Leptospirosis essentially affects human following contact with rodent urine-contaminated water. As such, it was mainly found associated with rice culture, recreational activities and flooding. This is also the reason why it has mainly been investigated in temperate as well as warm and humid regions, while arid zones have been only very occasionally monitored for this disease. In particular, data for West African countries are extremely scarce. Here, we took advantage of an extensive survey of urban rodents in Niamey, Niger, in order to look for rodent-borne pathogenic Leptospira species presence and distribution across the city. To do so, we used high throughput bacterial 16S-based metabarcoding, lipL32 gene-targeting RT-PCR, rrs gene sequencing and VNTR typing as well as GIS-based multivariate spatial analysis. Our results show that leptospires seem absent from the core city where usual Leptospira reservoir rodent species (namely R. rattus and M. natalensis) are yet abundant. On the contrary, L. kirschneri was detected in Arvicanthis niloticus and Cricetomys gambianus, two rodent species that are restricted to irrigated cultures within the city. Moreover, the VNTR profiles showed that rodent-borne leptospires in Niamey belong to previously undescribed serovars. Altogether, our study points towards the importance of market gardening in maintain and circulation of leptospirosis within Sahelian cities. In Africa, irrigated urban agriculture constitutes a pivotal source of food supply, especially in the context of the ongoing extensive urbanization of the continent. With this in mind, we speculate that leptospirosis may represent a zoonotic disease of concern also in arid regions that would deserve to be more rigorously surveyed, especially in urban agricultural settings.

Urban Market Gardening and Rodent-Borne Pathogenic Leptospira in Arid Zones: A Case Study in Niamey, Niger.

Directory of Open Access Journals (Sweden)

Gauthier Dobigny

Full Text Available Leptospirosis essentially affects human following contact with rodent urine-contaminated water. As such, it was mainly found associated with rice culture, recreational activities and flooding. This is also the reason why it has mainly been investigated in temperate as well as warm and humid regions, while arid zones have been only very occasionally monitored for this disease. In particular, data for West African countries are extremely scarce. Here, we took advantage of an extensive survey of urban rodents in Niamey, Niger, in order to look for rodent-borne pathogenic Leptospira species presence and distribution across the city. To do so, we used high throughput bacterial 16S-based metabarcoding, lipL32 gene-targeting RT-PCR, rrs gene sequencing and VNTR typing as well as GIS-based multivariate spatial analysis. Our results show that leptospires seem absent from the core city where usual Leptospira reservoir rodent species (namely R. rattus and M. natalensis are yet abundant. On the contrary, L. kirschneri was detected in Arvicanthis niloticus and Cricetomys gambianus, two rodent species that are restricted to irrigated cultures within the city. Moreover, the VNTR profiles showed that rodent-borne leptospires in Niamey belong to previously undescribed serovars. Altogether, our study points towards the importance of market gardening in maintain and circulation of leptospirosis within Sahelian cities. In Africa, irrigated urban agriculture constitutes a pivotal source of food supply, especially in the context of the ongoing extensive urbanization of the continent. With this in mind, we speculate that leptospirosis may represent a zoonotic disease of concern also in arid regions that would deserve to be more rigorously surveyed, especially in urban agricultural settings.

Agreement between magnetic resonance imaging and ultrasonography in the classification of Schistosomal periportal fibrosis, according to Niamey's criteria

Energy Technology Data Exchange (ETDEWEB)

Scortegagna Junior, Eduardo; Leao, Alberto Ribeiro de Souza; Sales, Danilo Moulin; Shigueoka, David Carlos; D' Ippolito, Giuseppe [Universidade Federal de Sao Paulo (UNIFESP-EPM), Sao Paulo, SP (Brazil). Dept. of Imaging Diagnosis]. E-mail: E-mail: giuseppe_dr@uol.com.br; Santos, Jose Eduardo Mourao; Colleoni Neto, Ramiro [Universidade Federal de Sao Paulo (UNIFESP-EPM), Sao Paulo, SP (Brazil); Aguiar, Luciane Aparecida Kopke de; Brant, Paulo Eugenio [Universidade Federal de Sao Paulo (UNIFESP-EPM), Sao Paulo, SP (Brazil). Dept. of Gastroenterology; Borges, Durval Rosa [Universidade Federal de Sao Paulo (UNIFESP-EPM), Sao Paulo, SP (Brazil). Dept. of Medicine

2008-01-15

Objective: To evaluate the reproducibility of magnetic resonance imaging and the agreement between ultrasound and magnetic resonance imaging in the classification of periportal fibrosis in patients with schistosomiasis based on Niamey's qualitative criteria. Materials and methods: A prospective, double-blinded study was conducted between February 2005 and June 2006 with 20 patients (10 men and 10 women, with ages ranging between 24 and 60 years, mean age 42.7 years) diagnosed with schistosomiasis mansoni. Both ultrasound and magnetic resonance images were independently evaluated by two experienced observers. Interobserver agreement was evaluated for findings of periportal fibrosis on magnetic resonance images and in a comparison between magnetic resonance and ultrasound images. Results: The analysis of magnetic resonance images showed total interobserver agreement in 14 patients (70%). The comparison between ultrasound and magnetic resonance imaging showed agreement between images in only six cases (30%) by observer 1, and in eight cases (40%) by observer 2. Conclusion: Magnetic resonance imaging presents a good reproducibility in the evaluation of periportal fibrosis in later stages of schistosomiasis, however, the correlation between magnetic resonance imaging and ultrasound is poor. (author)

One-neutron knockout from Ne24-28 isotopes

CERN Document Server

Rodriguez-Tajes, C; Caamano, M; Faestermann, T; Cortina-Gil, D; Zhukov, M; Simon, H; Nilsson, T; Borge, M J G; Alvarez-Pol, H; Winkler, M; Prochazka, A; Nociforo, C; Weick, H; Kanungo, R; Perez-Loureiro, D; Kurtukian, T; Suemmerer, K; Eppinger, K; Perea, A; Chatillon, A; Maierbeck, P; Benlliure, J; Pascual-Izarra, C; Gernhaeuser, R; Geissel, H; Aumann, T; Kruecken, R; Larsson, K; Tengblad, O; Benjamim, E; Jonson, B; Casarejos, E

2010-01-01

One-neutron knockout reactions of Ne24-28 in a beryllium target have been studied in the Fragment Separator (FRS), at GSI. The results include inclusive one-neutron knockout cross-sections as well as longitudinal-momentum distributions of the knockout fragments. The ground-state structure of the neutron-rich neon isotopes was obtained from an analysis of the measured momentum distributions. The results indicate that the two heaviest isotopes, Ne-27 and Ne-28, are dominated by a configuration in which a s(1/2) neutron is coupled to an excited state of the Ne-26 and Ne-27 core, respectively. (C) 2010 Elsevier B.V. All rights reserved.

27 CFR 28.214 - Notice and claim, Form 1582-A (5120.24).

Science.gov (United States)

2010-04-01

... AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS EXPORTATION OF ALCOHOL Exportation of Wine With Benefit of Drawback § 28.214 Notice and claim, Form 1582-A (5120.24). Claim for allowance of drawback of internal revenue taxes on wines removed under the provisions of § 28.211 and § 28.212, shall be prepared by...

Order no 058/MME/DAAF from June 13, 2003 provides for the creation, attributions and organization of Departmental Directorates, Direction of urban Niamey's communauty and Arlit's Arrondissement Service of the Ministry of Mines and Energy

International Nuclear Information System (INIS)

Rabiou Hassane, Yari

2003-01-01

This order provides for the creation, attributions and organization of Departemental Directorates, Direction of urban Niamey's communauty and Arlit's Arrondissement Service of the Ministry of Mines and Energy. It is created a Departmental Directorate of Mines and Energy into each of the following places of region: AGADEZ, DIFFA, , MARADI, TAHOUA, TILLABERI and ZINDER, and Direction of urban Niamey's communauty and Arlit's Arrondissement Service of the Ministry of Mines and Energy. Each Departmental and communal Directorate is constitued of: a service of the Geology's Research and Mining, Mines service, a Service of Electricity and new Energies and renewlables, a Service of hydrocarbures and an Administrative and Financial Service. Arrondissement Service includes: a Division of Mines and Geology, a Division of Energy and an admistrative and Financial Division. [fr

One-neutron knockout from {sup 24-28}Ne isotopes

Energy Technology Data Exchange (ETDEWEB)

Rodriguez-Tajes, C., E-mail: carme.rodriguez@usc.e [Departamento de Fisica de Particulas, Universidade de Santiago de Compostela, 15782 Santiago de Compostela (Spain); Cortina-Gil, D.; Alvarez-Pol, H. [Departamento de Fisica de Particulas, Universidade de Santiago de Compostela, 15782 Santiago de Compostela (Spain); Aumann, T. [GSI Helmholtzzentrum fuer Schwerionenforschung, 64291 Darmstadt (Germany); Benjamim, E.; Benlliure, J. [Departamento de Fisica de Particulas, Universidade de Santiago de Compostela, 15782 Santiago de Compostela (Spain); Borge, M.J.G. [Instituto de Estructura de la Materia, CSIC, 28006 Madrid (Spain); Caamano, M.; Casarejos, E. [Departamento de Fisica de Particulas, Universidade de Santiago de Compostela, 15782 Santiago de Compostela (Spain); Chatillon, A. [GSI Helmholtzzentrum fuer Schwerionenforschung, 64291 Darmstadt (Germany); Eppinger, K.; Faestermann, T. [Physik Department E12, Technische Universitaet Muenchen, 85748 Garching (Germany); Gascon, M. [Departamento de Fisica de Particulas, Universidade de Santiago de Compostela, 15782 Santiago de Compostela (Spain); Geissel, H. [GSI Helmholtzzentrum fuer Schwerionenforschung, 64291 Darmstadt (Germany); Gernhaeuser, R. [Physik Department E12, Technische Universitaet Muenchen, 85748 Garching (Germany); Jonson, B. [Fundamental Fysik, Chalmers Tekniska Hoegskola, 412 96 Goeteborg (Sweden); PH Department, CERN, 1211 Geneve 23 (Switzerland); Kanungo, R. [Astronomy and Physics Department, Saint Mary' s University, Halifax, NS B3H 3C3 (Canada); Kruecken, R. [Physik Department E12, Technische Universitaet Muenchen, 85748 Garching (Germany); Kurtukian, T. [Departamento de Fisica de Particulas, Universidade de Santiago de Compostela, 15782 Santiago de Compostela (Spain); Larsson, K. [Fundamental Fysik, Chalmers Tekniska Hoegskola, 412 96 Goeteborg (Sweden)

2010-04-05

One-neutron knockout reactions of {sup 24-28}Ne in a beryllium target have been studied in the Fragment Separator (FRS), at GSI. The results include inclusive one-neutron knockout cross-sections as well as longitudinal-momentum distributions of the knockout fragments. The ground-state structure of the neutron-rich neon isotopes was obtained from an analysis of the measured momentum distributions. The results indicate that the two heaviest isotopes, {sup 27}Ne and {sup 28}Ne, are dominated by a configuration in which a s{sub 1/2} neutron is coupled to an excited state of the {sup 26}Ne and {sup 27}Ne core, respectively.

Giant quadrupole resonance in 24Mg, 27Al, and 28Si

International Nuclear Information System (INIS)

Youngblood, D.H.; Rozsa, C.M.; Moss, J.M.; Brown, D.R.; Bronson, J.D.

1977-01-01

The giant-resonance region of 24 Mg, 27 Al, and 28 Si was studied by inelastic scattering of 126-MeV α particles. In contrast to results at 96 MeV, considerable clustering of E2 strength was observed for 27 Al at E/sub x/ approx. 20.1 MeV with GAMMA approx. 7.6 MeV exhausting about 35% of the E2 energy weighted sum rule. E2 strength was also located in 24 Mg in two clusters of states at E-bar/sub x/ approx. 18.2, 24.4 MeV; however, contributions from other multipoles cannot be neglected. In 28 Si a multipeaked group was observed at E/sub x/ approx. 19.4 MeV with GAMMA approx. 4 MeV but no L assignment was made. The energy dependence of the cross section for the giant quadrupole resonance was found to be consistent with distorted-wave Born approximation predictions

Management & communication programme

CERN Multimedia

Nathalie Dumeaux

2006-01-01

Calendar of courses for September to December 2006 Please check our Web site to find out the number of places available, which may vary. Management Curriculum 2nd semester 2006 Titres Dates Langue Quality Management 18, 19 September Bilingual Managing Teams 19, 20, 21 September English Communiquer efficacement - résidentiel 20, 21, 22 septembre Bilingue Personal Awareness & Impact 26, 27, 28 September Bilingual Introduction to Leadership 4, 5, 6 October Bilingue IProject Scheduling & Costing 12, 13 October English CDP-SL part 1 17, 18, 19 October English Personal Awareness & Impact 23, 24 October Bilingual Communicating to Convince 23, 24, 25 October Bilingual CDP-GL part 2 25, 26, 27 October English CDP-GL part 1 22, 23, 24 November Bilingual Risk Management 20, 21 December Bilingual Communication curriculum 2nd semester 2006 Titres Dates Langue Techniques d'exposé et de présentation 18, 19 septembre + 16 octobre Français Communi...

27 CFR 28.218 - Disposition of Forms 1582-A (5120.24).

Science.gov (United States)

2010-04-01

... AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS EXPORTATION OF ALCOHOL Exportation of Wine With Benefit of Drawback § 28.218 Disposition of Forms 1582-A (5120.24). On removal of the wines from the...

Déjouer le spectacle de la violence. Représenter les événements du 11 septembre 2001

Directory of Open Access Journals (Sweden)

Bertrand GERVAIS

2011-09-01

Full Text Available Comment représenter les événements du 11 septembre 2001 sans pour autant alimenter le spectacle qui les a déjà mis en forme? Comment aller au-delà du spectaculaire et rejoindre une mise en discours et en image qui permette de dépasser la simple répétition? Il faut déconstruire ce spectacle, défaire la représentation et aller contre le grain de l’image. Il faut transformer les tours du World Trade Center en figures de l’imaginaire. Au lieu d’inciter à une exacerbation de la représentation, qui respecte la logique du spectaculaire, il faut chercher à effacer les tours, à les dégager des dispositifs discursifs et iconiques que maintiennent leur présence naïve dans l’imaginaire contemporain pour les réinvestir sur un tout autre mode, opaque plutôt que transparent, à mille lieues des habituels effets de réel. Il faut effacer les tours. C’est bien ce qu’avait compris Art Spiegelman, le dessinateur new yorkais. La livraisondu 24 septembre 2001 du magazine The New Yorker, premier numéro après les événements du 11 septembre, présente en page couverture une œuvre d’une rare intensité. En fait, la une imaginée par Art Spiegelman est une page monochrome où les deux tours du world Trade Center sont figurées en noir sur un fond noir. Leurs contour et forme apparaissent grâce à une légère dépression à la surface du papier. L’œuvre, reproduite sur la page couverture de In the Shadow of No Towers (2004 propose une version minimaliste des attentats, tablant sur l’élimination de la couleur et sur une représentation aux limites de la figuration. Une stratégie complémentaire de cet effacement est proposée par Michal Kosakowski dans son film expérimental Just Like the Movies (21 minutes, 2006. Ce n’est plus l’imaginaire des comics du début du vingtième siècle qui est sollicité, mais celui plus récent de la production hollywoodienne. Le film de Kosakowski est un extraordinaire exemple de �

Superconducting ECR ion source: From 24-28 GHz SECRAL to 45 GHz fourth generation ECR

Science.gov (United States)

Zhao, H. W.; Sun, L. T.; Guo, J. W.; Zhang, W. H.; Lu, W.; Wu, W.; Wu, B. M.; Sabbi, G.; Juchno, M.; Hafalia, A.; Ravaioli, E.; Xie, D. Z.

2018-05-01

The development of superconducting ECR source with higher magnetic fields and higher microwave frequency is the most straight forward path to achieve higher beam intensity and higher charge state performance. SECRAL, a superconducting third generation ECR ion source, is designed for 24-28 GHz microwave frequency operation with an innovative magnet configuration of sextupole coils located outside the three solenoids. SECRAL at 24 GHz has already produced a number of record beam intensities, such as 40Ar12+ 1.4 emA, 129Xe26+ 1.1 emA, 129Xe30+ 0.36 emA, and 209Bi31+ 0.68 emA. SECRAL-II, an upgraded version of SECRAL, was built successfully in less than 3 years and has recently been commissioned at full power of a 28 GHz gyrotron and three-frequency heating (28 + 45 + 18 GHz). New record beam intensities for highly charged ion production have been achieved, such as 620 eμA 40Ar16+, 15 eμA 40Ar18+, 146 eμA 86Kr28+, 0.5 eμA 86Kr33+, 53 eμA 129Xe38+, and 17 eμA 129Xe42+. Recent beam test results at SECRAL and SECRAL II have demonstrated that the production of more intense highly charged heavy ion beams needs higher microwave power and higher frequency, as the scaling law predicted. A 45 GHz superconducting ECR ion source FECR (a first fourth generation ECR ion source) is being built at IMP. FECR will be the world's first Nb3Sn superconducting-magnet-based ECR ion source with 6.5 T axial mirror field, 3.5 T sextupole field on the plasma chamber inner wall, and 20 kW at a 45 GHz microwave coupling system. This paper will focus on SECRAL performance studies at 24-28 GHz and technical design of 45 GHz FECR, which demonstrates a technical path for highly charged ion beam production from 24 to 28 GHz SECRAL to 45 GHz FECR.

Rapport de frais de 2016-2017 pour Margaret Biggs | CRDI - Centre ...

International Development Research Centre (IDRC) Digital Library (Canada)

Rapport de frais de 2016-2017 pour Margaret Biggs. Total des frais de déplacement : CAD$6,727.48. Participation à la cérémonie de remise des prix Canada Gairdner 2016. 27 octobre 2016 au 28 octobre 2016. CAD$859.79. Assister à des réunions internes organisées par le CRDI. 9 septembre 2016 au 29 septembre ...

African Journal of Neurological Sciences - 2009 Vol. 28 No 1

African Journals Online (AJOL)

encéphalocèle occipital et alerter pour une stratégie préventive. Méthode. Il s'agit d'une étude prospective en série continue réalisée de janvier 1999 à Mars 2008 dans le service de neurochirurgie de l'hôpital national de Niamey au Niger. Après examen ...

24,25,28-Trihydroxyvitamin D2 and 24,25,26-trihydroxyvitamin D2: Novel metabolites of vitamin D2

International Nuclear Information System (INIS)

Reddy, G.S.; Tserng, K.

1990-01-01

Understanding of the inactivation pathways of 25-hydroxyvitamin D 2 and 24-hydroxyvitamin D 2 , the two physiologically significant monohydroxylated metabolites of vitamin D 2 , is of importance, especially during hypervitaminosis D 2 . At present, little information is available regarding the inactivation pathway of 25-hydroxyvitamin D 2 except its further metabolism into 24,25-dihydroxyvitamin D 2 . In our present study, the authors investigated the metabolic fate of 25-hydroxyvitamin D 2 in the isolated perfused rat kidney and demonstrated its conversion not only into 24,25-dihydroxyvitamin D 2 but also into two other new metabolites, namely, 24,25,28-trihydroxyvitamin D 2 and 24,25,26-trihydroxyvitamin D 2 . The structure identification of the new metabolites was established by the techniques of ultraviolet absorption spectrophotometry and mass spectrometry and by the characteristic nature of each new metabolite's susceptibility to sodium metaperiodate oxidation. In order to demonstrate the physiological significance of the two new trihydroxy metabolites of vitamin D 2 , induced hypervitaminosis D 2 in a rat using [3α- 3 H]vitamin D 2 and analyzed its plasma for the various [3α- 3 H]vitamin D 2 metabolites on two different high-pressure liquid chromatography systems. The results indicate that both 24,25,26-trihydroxyvitamin D 2 and 24,25,26-trihydroxyvitamin D 2 circulate in the vitamin D 2 intoxicated rat in significant amounts along with other previously identified monohydroxy and dihydroxy metabolites of vitamin D 2 , namely, 24-hydroxyvitamin D 2 , 25-hydroxyvitamin D 2 , and 24,25-dihydroxyvitamin D 2

Properties of 20Na, 24Al, 28P, 32Cl, and 36K for studies of explosive hydrogen burning

International Nuclear Information System (INIS)

Wrede, C.; Clark, J. A.; Deibel, C. M.; Faestermann, T.; Parikh, A.; Bishop, S.; Eppinger, K.; Kruecken, R.; Lepyoshkina, O.; Rugel, G.; Hertenberger, R.; Wirth, H.-F.; Chen, A. A.; Freeman, B. M.; Setoodehnia, K.

2010-01-01

The radiative proton-capture reactions 19 Ne(p,γ) 20 Na, 23 Mg(p,γ) 24 Al, 27 Si(p,γ) 28 P, 31 S(p,γ) 32 Cl, and 35 Ar(p,γ) 36 K potentially influence energy generation and/or nucleosynthesis during explosive hydrogen burning in classical novae and/or type I x-ray bursts. The thermonuclear rates of these reactions are dependent on resonance energies E r =E x -Q and strengths ωγ. The 20 Ne( 3 He,t) 20 Na, 24 Mg( 3 He,t) 24 Al, 28 Si( 3 He,t) 28 P, 32 S( 3 He,t) 32 Cl, and 36 Ar( 3 He,t) 36 K reactions have been measured using a 32-MeV, 3 He 2+ beam; ion-implanted carbon-foil targets developed at the University of Washington; and the Munich Q3D magnetic spectrograph. This experiment has already yielded precision mass measurements of 20 Na, 24 Al, 28 P, and 32 Cl [C. Wrede et al., Phys. Rev. C 81, 055503 (2010)], which are used presently to constrain the corresponding (p,γ) reaction Q values. The new 24 Al and 28 P masses resolve a discrepancy in the energy of the lowest-energy resonance in the 23 Mg(p,γ) 24 Al reaction and better constrain a direct measurement of its strength. Excitation energies in 32 Cl and 36 K have also been measured. An important new proton-unbound level has been found at E x =2196.9(7) keV in 36 K and the uncertainties in 36 K excitation energies have been reduced by over an order of magnitude. Using the new data on 36 K, the A=36, T=1 triplets have been reassigned. The thermonuclear 35 Ar(p,γ) 36 K reaction rate is found to be much higher than a commonly adopted rate and this could affect energy generation in type I x-ray bursts.

Orienteering club

CERN Multimedia

Orienteering Club

2016-01-01

Course d'orientation Calendrier des courses d’orientation Coupe genevoise d’automne 2016 Samedi 3 septembre : La Faucille (01) Samedi 10 septembre : Prémanon (39) Samedi 17 septembre : Saint-Cergue (VD) Samedi 24 septembre : Jorat / Corcelles (VD) Samedi 1 octobre: Bière - Ballens (VD) -relais Vendredi 14 octobre : Parc Mon Repos (GE) - nocturne Samedi 15 octobre : Terrasse de Genève (74) Samedi 29 octobre : Bonmont (VD) Samedi 5 novembre : Pomier (74) – one-man-relay - Finale   Courses ouvertes à toutes et à tous, sportifs, familles, débutants ou confirmés, du CERN ou d’ailleurs. Cinq circuits disponibles, ceci va du facile court (2 km) adapté aux débutants et aux enfants jusqu’au parcours technique long de 6 km pour les chevronnés en passant par les parcours facile moyen (4&am...

Peer review of the Nevada Nuclear Waste Storage Investigations, August 24-28, 1981

Energy Technology Data Exchange (ETDEWEB)

NONE

1984-02-01

On August 24-28, 1981, a peer review of three major areas of the Nevada Nuclear Waste Storage Investigations was conducted at the Riviera Hotel in Las Vegas, Nevada. The three investigative areas were: (1) geology/hydrology, (2) geotechnical/geoengineering, and (3) environmental studies. A separate review panel was established for each of the investigative areas which was composed of experts representing appropriate fields of expertise. A total of twenty nationally known or prominent state and local experts served on the three review panels.

Peer review of the Nevada Nuclear Waste Storage Investigations, August 24-28, 1981

International Nuclear Information System (INIS)

1984-02-01

On August 24-28, 1981, a peer review of three major areas of the Nevada Nuclear Waste Storage Investigations was conducted at the Riviera Hotel in Las Vegas, Nevada. The three investigative areas were: (1) geology/hydrology, (2) geotechnical/geoengineering, and (3) environmental studies. A separate review panel was established for each of the investigative areas which was composed of experts representing appropriate fields of expertise. A total of twenty nationally known or prominent state and local experts served on the three review panels

Broadband pulsations from PSR B1821–24: Implications for emission models and the pulsar population of M28

Energy Technology Data Exchange (ETDEWEB)

Johnson, T. J. [National Research Council Research Associate, National Academy of Sciences, Washington, DC 20001 (United States); Guillemot, L.; Freire, P. C. C. [Max-Planck-Institut für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn (Germany); Kerr, M.; Romani, R. W.; Wood, M. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Cognard, I. [Laboratoire de Physique et Chimie de l' Environnement, LPCE UMR 6115 CNRS, F-45071 Orléans Cedex 02 (France); Ray, P. S.; Wolff, M. T.; Grove, J. E.; Cheung, C. C. [Space Science Division, Naval Research Laboratory, Washington, DC 20375-5352 (United States); Bégin, S. [Département de physique, génie physique et optique, Université Laval, Québec (Canada); Janssen, G. H.; Espinoza, C. M. [Jodrell Bank Centre for Astrophysics, School of Physics and Astronomy, The University of Manchester, Manchester M13 9PL (United Kingdom); Venter, C. [Centre for Space Research, North-West University, Potchefstroom Campus, Private Bag X6001, 2520 Potchefstroom (South Africa); Casandjian, J. M. [Laboratoire AIM, CEA-IRFU/CNRS/Université Paris Diderot, Service d' Astrophysique, CEA Saclay, 91191 Gif sur Yvette (France); Stairs, I. H. [Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver, BC V6T 1Z1 (Canada); Camilo, F. [Columbia Astrophysics Laboratory, Columbia University, New York, NY 10027 (United States); Ferrara, E. C.; Harding, A. K., E-mail: tyrel.j.johnson@gmail.com, E-mail: guillemo@mpifr-bonn.mpg.de, E-mail: kerrm@stanford.edu, E-mail: icognard@cnrs-orleans.fr, E-mail: Paul.Ray@nrl.navy.mil [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); and others

2013-12-01

We report a 5.4σ detection of pulsed gamma rays from PSR B1821–24 in the globular cluster M28 using ∼44 months of Fermi Large Area Telescope (LAT) data that have been reprocessed with improved instrument calibration constants. We constructed a phase-coherent ephemeris, with post-fit residual rms of 3 μs, using radio data spanning ∼23.2 yr, enabling measurements of the multi-wavelength light-curve properties of PSR B1821–24 at the milliperiod level. We fold RXTE observations of PSR B1821–24 from 1996 to 2007 and discuss implications on the emission zones. The gamma-ray light curve consists of two peaks separated by 0.41 ± 0.02 in phase, with the first gamma-ray peak lagging behind the first radio peak by 0.05 ± 0.02 in phase, consistent with the phase of giant radio pulses. We observe significant emission in the off-peak interval of PSR B1821–24 with a best-fit LAT position inconsistent with the core of M28. We do not detect significant gamma-ray pulsations at the spin or orbital periods from any other known pulsar in M28, and we place limits on the number of energetic pulsars in the cluster. The derived gamma-ray efficiency, ∼2%, is typical of other gamma-ray pulsars with comparable spin-down power, suggesting that the measured spin-down rate (2.2 × 10{sup 36} erg s{sup –1}) is not appreciably distorted by acceleration in the cluster potential. This confirms PSR B1821–24 as the second very energetic millisecond pulsar in a globular cluster and raises the question of whether these represent a separate class of objects that only form in regions of very high stellar density.

2018-03-28T03:12:24Z https://www.ajol.info/index.php/all/oai oai:ojs ...

African Journals Online (AJOL)

article/68491 2018-03-28T03:12:24Z wsa:ART Characterisation of the inorganic chemistry of surface waters in South Africa Huizenga, JM Inorganic water chemistry, inorganic chemistry index, South Africa, surface waters The main purpose of this ...

28 CFR 94.24 - Determination of award.

Science.gov (United States)

2010-07-01

....24 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CRIME VICTIM SERVICES International Terrorism Victim Expense Reimbursement Program Coverage § 94.24 Determination of award. After review of each... fact and conclusions of law supporting it. A copy of the determination shall be mailed to the claimant...

PTP1B inhibitory and cytotoxic C-24 epimers of Δ28-24-hydroxy stigmastane-type steroids from the brown alga Dictyopteris undulata Holmes.

Science.gov (United States)

Feng, Mei-Tang; Wang, Ting; Liu, Ai-Hong; Li, Jia; Yao, Li-Gong; Wang, Bin; Guo, Yue-Wei; Mao, Shui-Chun

2018-02-01

Ten stigmastane-type steroids bearing unusual Δ 28 -24-hydroxy side chains, dictyopterisins A-J, including three pairs of C-24 epimers, dictyopterisins B/C, F/G, and I/J, were isolated from the brown alga Dictyopteris undulata Holmes, together with two previously reported analogues, (24S)- and (24R)-saringosterol. Their structures were elucidated on the basis of extensive spectroscopic analysis, with their absolute configurations at the stereogenic center C-24 of the side chain being assigned by a direct comparison of 1 H NMR data with those of related known compounds. The absolute configurations of the steroidal nuclei of dictyopterisins A, B, and H were determined using the modified Mosher's method. The mixture of dictyopterisins D and E and dictyopterisin I exhibited promising PTP1B inhibitory activities with IC 50 values of 1.88 and 3.47 μM, respectively, comparable to the positive control oleanolic acid (IC 50 , 2.78 μM). In addition, the mixture of dictyopterisins D and E and dictyopterisins F-J displayed significant cytotoxicities against the human cancer cell lines HL-60 (IC 50 from 1.02 to 2.70 μM) and A-549 (IC 50 from 1.35 to 2.85 μM). Copyright © 2017 Elsevier Ltd. All rights reserved.

Proceeding of the ACM/IEEE-CS Joint Conference on Digital Libraries (1st, Roanoke, Virginia, June 24-28, 2001).

Science.gov (United States)

Association for Computing Machinery, New York, NY.

Papers in this Proceedings of the ACM/IEEE-CS Joint Conference on Digital Libraries (Roanoke, Virginia, June 24-28, 2001) discuss: automatic genre analysis; text categorization; automated name authority control; automatic event generation; linked active content; designing e-books for legal research; metadata harvesting; mapping the…

Orienteering Club

CERN Multimedia

CLUB D'ORIENTATION

2013-01-01

Calendrier de la coupe d’automne Le Club d’orientation du CERN, en partenariat avec d’autres clubs de la région, vous propose, pour cette nouvelle coupe d’automne genevoise, une série de 10 courses. Le club du O’Jura donnera le coup d’envoi le samedi 31 août. Les courses s’enchaîneront selon le calendrier suivant : Samedi 31 août : Prémanon (39) - longue distance Samedi 14 septembre : La Faucille (01) - longue distance Samedi 21 septembre : Saint Cergue (VD) - longue distance Samedi 28 septembre : Ballens (VD) - relais Samedi 5 octobre : La Pile (VD) - longue distance Vendredi 11 octobre : Les Evaux (GE) - nocturne Samedi 12 octobre : Grand Jorat, Savigny (VD) - longue distance Samedi 19 octobre : Terrasses de Genève (74) - longue distance Samedi 26 octobre : Prémanon (39) - longue distance Samedi 2 novembre : Bois Tollot (GE) - score - Finale Les &a...

Analyses of electron and proton scattering to low excitation isoscalar states in 20Ne, 24Mg and 28Si

International Nuclear Information System (INIS)

Amos, K.; Bauhoff, W.

1983-01-01

Intermediate energy inelastic proton scattering differential cross section and polarization data from the 2 1 + states in 24 Mg and 28 Si and from the 4 1 + states in 28 Si have been analysed using the Distorted Wave Approximation with large basis models of nuclear structure. These structure models were tested by use in analyses of the longitudinal form factors obtained from inelastic electron scattering, so that analyses of the intermediate energy (p,p') data from the same transitions are then sensitive tests of the two-nucleon t-matrix. Data from these and other 2 1 + transitions in 12 C and 20 Ne at 49 MeV (24 MeV in the case of 20 Ne), were also analysed to compare models of t-matrices at lower energies. An ancilliary study of the momentum transfer dependence of effective charges has been made as both s-d shell and large basis structure models have been used to compare with form factor data up to momentum transfers of 2.5 fm -1 . The deduced momentum dependence of the effective charges is significant

Characterization of Dairy Production Systems and Analysis of Milk Promotion Strategies in Rural and Urban Areas in Niger: Case of the Urban Community of Niamey and Rural District of Filingue

Directory of Open Access Journals (Sweden)

A. R. Boukari

2007-01-01

Full Text Available Livestock breeding and particularly milk production play a major role in poverty alleviation and economic growth. The present study aimed at characterizing the production systems and opening avenues for milk production in a (suburban [urban community of Niamey (UCN] and in a rural environment [rural district of Filingue (RDF] in Niger. In UCN, surveys were carried out in 35 dairy sites randomly selected among the 150 already indexed within a radius of 50 km from the capital. Out of these, 12 sites were selected allowing the questionnaire to be administered to 169 heads of household. In RDF, 49 heads of household, located in five villages within 75 km of Filingue, were surveyed. Results showed that in UCN, breeders owned few dairy cows (five on average, i.e. 28% of the bovine herd, which produced in all seasons 7 to 10 L/household/day; they marketed fresh milk more often than in RDF because they had access to dairy transformation units. In RDF, they owned more cows (ten on average, i.e. 52% of the bovine herd, which produced only during the rainy season and the cold dry season (between 0 to 10 and 10 to 20 L/household/ day according to 66 and 20% of the persons surveyed, respectively; dairy products were transformed more often before sale (melted butter, curdled milk, cheese. The innovations observed in the surveyed breeders were related to changes in herd management. The constraints to dairy production development in the urban area concerned in particular production and preservation of good-quality fresh milk all the way to transforming units or consumers, while in the rural area, it concerned the lack of avenues. In urban areas, it is essential to organize the supply of food inputs, evening collection of milk and to popularize technical topics and innovating practices.

Communication & Management

CERN Multimedia

2006-01-01

Calendar of courses for September to December 2006 Please check our Web site to find out the number of places available, which may vary. Management Curriculum 2nd semester 2006 Titles Dates Language Quality Management 18, 19 September Bilingual Managing Teams 19, 20, 21 September English Communicating Effectively - Residential 20, 21, 22 septembre Bilingual (Full) Personal Awareness & Impact 26, 27, 28 September Bilingual Introduction to Leadership 4, 5, 6 October Bilingue IProject Scheduling & Costing 12, 13 October English CDP-SL part 1 Several sessions Dates to be fixed English or French Personal Awareness & Impact 23, 24 October Bilingual Communicating to Convince 23, 24, 25 October Bilingual CDP-GL part 2 25, 26, 27 October English CDP-GL part 1 Dates to be fixed Bilingual Risk Management 20, 21 December Bilingual Communication curriculum 2nd semester 2006 Titles Dates Language Techniques d'exposé et de présentation 18, 19 s...

Management & Communication

CERN Multimedia

2006-01-01

Calendar of courses for September to December 2006 Please check our Web site to find out the number of places available, which may vary. Management Curriculum 2nd semester 2006 Titles Dates Language Quality Management 18, 19 September Bilingual Managing Teams 19, 20, 21 September English Communicating Effectively - Residential 20, 21, 22 septembre Bilingual (Full) Personal Awareness & Impact 26, 27, 28 September Bilingual Introduction to Leadership 4, 5, 6 October Bilingue IProject Scheduling & Costing 12, 13 October English CDP-SL part 1 Several sessions Dates to be fixed English or French Personal Awareness & Impact 23, 24 October Bilingual Communicating to Convince 23, 24, 25 October Bilingual CDP-GL part 2 25, 26, 27 October English CDP-GL part 1 Dates to be fixed Bilingual Risk Management 20, 21 December Bilingual Communication curriculum 2nd semester 2006 Titles Dates Language Techniques d'exposé et de présentation 18, 19 sept...

24 CFR 28.20 - Request for approval by the Department of Justice.

Science.gov (United States)

2010-04-01

... Department of Justice. 28.20 Section 28.20 Housing and Urban Development Office of the Secretary, Department....20 Request for approval by the Department of Justice. (a) If the General Counsel or designee... written request to the Department of Justice for approval to issue a complaint under § 28.25. (b) The...

The spin histories of PSR1821-24 in M28 and PSR1951+32 in CTB80

International Nuclear Information System (INIS)

White, N.E.; Stella, L.

1988-01-01

The spin histories of the 3.05-ms pulsar PSR 1821-24 in the globular cluster M28 and the pulsar PSR 1951 + 32 in the supernova remnant C + B80, show that the equation for the minimum possible period for the spin-up by accretion of an accreting magnetized neutron star is not correct. Also the equation should not be considered a 'hard' barrier when considering the magnetic field-period distribution of recycled radio pulsars. The rapid rotation period and period derivative of both pulsars are consistent with both having undergone a previous interval of accretion. (U.K.)

Évaluation des niveaux de contamination en éléments traces ...

African Journals Online (AJOL)

SARAH

30 juil. 2013 ... vallée de Gounti Yena est l'une des principales zones de cultures maraîchères de la ville de Niamey. Cette étude a pour ... 3,73 ; 8,19 ; 2137,28 ; 2,85; 5,17 et 157,51 mg/kg MS respectivement pour cadmium (Cd), chrome (Cr), cuivre (Cu), fer .... Ouest et zone Katako décharges, retenus en fonction de leurs ...

Management & Communication: Programme of Seminars September to December 2004

CERN Multimedia

Nathalie Dumeaux

2004-01-01

Situation : 13.07.2004 Bilingual seminars Dates Days Places Available Project Management 13, 14, 15 September 3 oui Introduction to Management 20, 21, 22 September 3 oui Managing by project 28, 29 September 2 oui Project Management Case study 8 October 1 oui Communication Techniques - 1 20, 21, 22 October 3 oui Quality Management 8, 9 November 2 oui Risk Management 6, 7 December 2 oui Seminars in English Communicating effectively 20 September, 1 october + 2, 3 November 4 yes Communicating effectively in your team 14, 15 October 2 yes Séminaires en Français Communiquer efficacement 21, 22 septembre + 12, 13 octobre 4 oui Techniques d'exposé et de présentation 27, 28 septembre + 18 octobre 3 oui Animer ou participer à une réunion de travail 15, 16, 17 novembre 3 oui * If you are interested in a seminar where there are no places available, please fill in an application form and we will contact you as soon as a new session is organised. MANAGEMENT & COMMUNICA...

Characterization of pulmonary protein profiles in response to zinc oxide nanoparticles in mice: a 24-hour and 28-day follow-up study

Directory of Open Access Journals (Sweden)

Pan CH

2015-07-01

Full Text Available Chih-Hong Pan,1,2,* Kai-Jen Chuang,3,4,* Jen-Kun Chen,5 Ta-Chih Hsiao,6 Ching-Huang Lai,2 Tim P Jones,7 Kelly A BéruBé,8 Gui-Bing Hong,9 Kin-Fai Ho,10,11 Hsiao-Chi Chuang12,13 1Institute of Occupational Safety and Health, Council of Labor Affairs, Executive Yuan, 2School of Public Health, National Defense Medical Center, 3School of Public Health, College of Public Health and Nutrition, 4Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 5Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, 6Graduate Institute of Environmental Engineering, National Central University, Taoyuan, Taiwan; 7School of Earth and Ocean Sciences, 8School of Biosciences, Cardiff University, Cardiff, Wales, UK; 9Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, Taiwan; 10Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, People’s Republic of China; 11Shenzhen Municipal Key Laboratory for Health Risk Analysis, Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, People’s Republic of China; 12School of Respiratory Therapy, College of Medicine, 13Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan *These authors contributed equally to this work Abstract: Although zinc oxide nanoparticles (ZnONPs are recognized to cause systemic disorders, little is known about the mechanisms that underlie the time-dependent differences that occur after exposure. The objective of this study was to investigate the mechanistic differences at 24 hours and 28 days after the exposure of BALB/c mice to ZnONPs via intratracheal instillation. An isobaric tag for the relative and absolute quantitation coupled with liquid chromatography/tandem mass spectrometry was used to identify the differential

African Journal of Science and Technology (AJST) DIVERSITY OF ...

African Journals Online (AJOL)

NORBERT OPIYO AKECH

ABSTRACT: This paper presents the first results on the water quality of the River Niger at Niamey based on the Chironomidae ... Key words: Chironomidae, River Niger, Niamey, water quality ...... of macroinvertebrates assemblages in the Azul-.

Bourse de perfectionnement professionnel : Agriculture et sécurité ...

International Development Research Centre (IDRC) Digital Library (Canada)

28 août 2017 ... Type. Subventions. Admissibilité. Pour être admissible, vous devez remplir les conditions suivantes : Être citoyen canadien, résident permanent du Canada ou citoyen d'un pays en développement et détenir un permis de travail canadien valide jusqu'au 30 septembre 2018;; Être inscrit au doctorat dans ...

International conference on information and communication technologies: From theory to applications, Damascus (SY), 24-28 April 2006, V. 1

International Nuclear Information System (INIS)

2006-01-01

This publication includes the papers presented at the International conference on information and communication technologies: From theory to applications held in Damascus (Syria) from 24-28 April 2006. This proceeding is published in two volumes and aims to provide an outstanding opportunity for both academic and industrial communities alike to address new trends and challenges, emerging technologies and progress in standards on topics relevant to today's fast moving areas of information and communication technologies. The papers cover state-of-the-art technologies, theoretical concepts, standards, products implementation, ongoing research projects and innovation applications of the IC technologies use

27 CFR 28.123 - Export marks.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.123..., or Transportation to a Manufacturing Bonded Warehouse § 28.123 Export marks. (a) General. In addition... filled under the provisions of part 24 of this chapter, the proprietor shall mark the word “Export” on...

La cohésion sociale : une solution ou un moteur de violence urbaine ...

International Development Research Centre (IDRC) Digital Library (Canada)

La cohésion sociale : une solution ou un moteur de violence urbaine ? 28 septembre 2016. Image. un policer qui gère une foule. Shaun Swingler. COLLECTION: HISTOIRE À SUCCÈS | VILLES SÛRES ET INCLUSIVES. La cohésion sociale peut jouer un rôle important dans l'établissement et le maintien de l'ordre dans les ...

Orienteering Club

CERN Multimedia

Club d’orientation

2012-01-01

En avant pour une nouvelle saison Le coup d’envoi de la coupe genevoise d’automne sera donné le samedi 1 septembre à la Givrine. Le Club, en partenariat avec d’autres clubs de la région, vous propose une série de 12 courses pour cet automne. Elles seront relativement variées puisque les organisateurs ont prévu un relais par équipe, une épreuve de nuit, une course au score, des épreuves longue ou moyenne distance, en terminant par un sprint le 10 novembre. Le calendrier devrait donc être le suivant : Samedi 1er septembre : Givrine sud (VD) - longue distance Samedi 8 septembre : Lamoura, le Sauget (39) - longue distance Samedi 15 septembre : La Dôle (F/VD) - longue distance Samedi 22 septembre : Mont Pélerin (VD) - longue distance Samedi 29 septembre : Saint Cergue (VD) -extra longue Samedi 6 octobre : Prémanon (39) - relais Vendr...

2138-IJBCS-Article-Amadou Haoua

African Journals Online (AJOL)

hp

Application des méthodes d'analyses statistiques multivariées à l'étude de la minéralisation des eaux de la ... Université Abdou Moumouni de Niamey, BP 10662 Niamey, Niger. ..... présentent pas de danger majeur pour la consommation ...

46 CFR 28.260 - Electronic position fixing devices.

Science.gov (United States)

2010-10-01

... Trade § 28.260 Electronic position fixing devices. Each vessel 79 feet (24 meters) or more in length must be equipped with an electronic position fixing device capable of providing accurate fixes for the... 46 Shipping 1 2010-10-01 2010-10-01 false Electronic position fixing devices. 28.260 Section 28...

21st Session of the International Poplar Commission (IPC-2000): poplar and willow culture: meeting the needs of society and the environment; 200 September 24-28; Vancouver, WA.

Science.gov (United States)

J.G. Isebrands; J. Richardson

2000-01-01

Research results and ongoing research activities on poplar and willow breeding, diseases, insects, production, and utilization are described in 220 abstracts from the International Poplar Commission meeting in Vancouver, Washington, September 24-28, 2000.

28 CFR 552.24 - Use of four-point restraints.

Science.gov (United States)

2010-07-01

... beyond eight hours requires the supervision of qualified health personnel. Mental health and qualified... Section 552.24 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT...-point restraints, qualified health personnel shall initially assess the inmate to ensure appropriate...

Etude de la qualité physico-chimique et biologique des eaux du ...

African Journals Online (AJOL)

Etude de la qualité physico-chimique et biologique des eaux du fleuve Niger à Niamey. ... le récepteur principal des rejets d'eaux usées de la ville de Niamey, capital du ... La description de ces taxons montre une variation de la structure des ...

Glycosides from the sea cucumber Cucumaria frondosa. IV. Structure of frondosides A{sub 2}-4, A{sub 2}-7, and A{sub 2}-8, three new minor monosulfated triterpene glycosides

Energy Technology Data Exchange (ETDEWEB)

Silchenko, A.S.; Avilov, S.A.; Antonov, A.S.; Kalinovsky, A.I.; Dmitrenok, P.S.; Kalinin, V.I. [Pacific Inst. of Bioorganic Chemistry, Far East Div. of the Russian Academy of Sciences, Vladivostok (Russian Federation)], E-mail: kalininv@piboc.dvo.ru; Woodward, C.; Collin, P.D. [Coastside Bio Resources Inc., Stonington, Maine (United States)

2005-12-15

Frondosides A{sub 2}-4, A{sub 2}-7, and A{sub 2}-8 are new monosulfated triterpene glycosides isolated from the sea cucumber Cucumaria frondosa. Their structures have been elucidated on the basis of spectral data (2D NMR and MS). Frondosides A{sub 2}-7 and A{sub 2}-8 are isomers and differ from each other only by the position of a double bond in their non-holostane-type aglycones. (author)

African Journal of Drug & Alcohol Studies, 12(1), 2013 Copyright ...

African Journals Online (AJOL)

1 avr. 2013 ... rePreSentAtionS SociAleS De lA conSoMMAtion De trAMADol Au niger,. PERCEPTIONS ET ... 1Faculté des Sciences de la Santé de Niamey, Niamey, Niger. 2Service de ..... féine : à propos de 8 cas et revue de la littérature.

Diversité des champignons basidiomycètes à carpophores inféodés ...

African Journals Online (AJOL)

SARAH

31 août 2017 ... Universidad de. Córdoba. 14071, Córdoba (España). 4. Laboratoire Garba Mounkaila, Département de Biologie, Faculté des Sciences et Techniques, Université Abdou. Moumouni de Niamey, BP. 10963, Niamey ..... fructification in central and southern Côte d'Ivoire. Insect. Soc. 58: 371–382. Lilleskov EA ...

AS_643_A4 OK

African Journals Online (AJOL)

AKA BOKO

Évaluation des rejets d'eaux usées de la ville de Niamey dans le fleuve Niger. Haoua AMADOU* .... Problématique de la gestion des eaux usées dans la communauté urbaine de. Niamey ..... MALAVOI et Y. SOUCHON, Hydrologie et dynamique hydro écologique des cours d'eau ; Revue ... control Eichornia crassipes Mart.

40 CFR 406.24 - Pretreatment standards for existing sources.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Pretreatment standards for existing sources. 406.24 Section 406.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GRAIN MILLS POINT SOURCE CATEGORY Corn Dry Milling Subcategory § 406.24...

Trimestre Dates Endroit Objet Transport Hébergement, repas et frais ...

International Development Research Centre (IDRC) Digital Library (Canada)

Chantal Taylor

Transport. Hébergement, repas et frais divers. Accueil. Total des dépenses. Trimestre 1 les 23 et 24 avril 2012. Washington, États-Unis. Réunions du 5 au 9 juin 2012. Rome, Italie. Réunions. 16 308,20. 2 468,26. 18 776,46 du 15 au 23 juin 2012. Le Cap, Afrique du Sud. Réunions. Trimestre 2 les 5 et 6 septembre 2012.

Fluctuations Saisonnieres Du Poids Vif D\\'ovins Djallonke Type ...

African Journals Online (AJOL)

La production totale d\\'acides gras volatils (AGV) présente également des différences significatives (p < 0,1 %) avec la saison. Les valeurs les plus élevées sont enregistrées pendant la saison de pluies en juin, juillet et août-septembre soit respectivement 24,25 ; 27,10 et 26,66 mmol/l. Des variations significatives (p < 0,1 ...

GAC-EPA

CERN Multimedia

GAC-EPA

2018-01-01

Le GAC organise des permanences avec entretiens individuels qui se tiennent le dernier mardi de chaque mois, sauf en juillet et décembre. La prochaine permanence se tiendra le : Mardi 24 avril de 13 h 30 à 16 h 00 Salle de réunion de l’Association du personnel Les permanences suivantes auront lieu les mardis 29 mai, 26 juin, 28 août, 25 septembre, 30 octobre et 27 novembre 2018. Les permanences du Groupement des Anciens sont ouvertes aux bénéficiaires de la Caisse de pensions (y compris les conjoints survivants) et à tous ceux qui approchent de la retraite. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association du personnel, les documents nécessaires. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’A...

GAC-EPA : Permanence le mardi 27 février

CERN Multimedia

GAC-EPA

2018-01-01

Le GAC organise des permanences avec entretiens individuels qui se tiennent le dernier mardi de chaque mois, sauf en juillet et décembre. La prochaine permanence se tiendra le : Mardi 27 février de 13 h 30 à 16 h 00 Salle de réunion de l’Association du personnel Les permanences suivantes auront lieu les mardis 27 mars, 24 avril, 29 mai, 26 juin, 28 août, 25 septembre, 30 octobre et 27 novembre 2018. Les permanences du Groupement des Anciens sont ouvertes aux bénéficiaires de la Caisse de pensions (y compris les conjoints survivants) et à tous ceux qui approchent de la retraite. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association du personnel, les documents nécessaires. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, au...

GAC-EPA

CERN Multimedia

GAC-EPA

2018-01-01

Le GAC organise des permanences avec entretiens individuels qui se tiennent le dernier mardi de chaque mois, sauf en juin, juillet et décembre. La prochaine permanence se tiendra le : Mardi 30 janvier de 13 h 30 à 16 h 00 Salle de réunion de l’Association du personnel Les permanences suivantes auront lieu les mardis 27 février, 27 mars, 24 avril, 29 mai, 26 juin, 28 août, 25 septembre, 30 octobre et 27 novembre 2018. Les permanences du Groupement des Anciens sont ouvertes aux bénéficiaires de la Caisse de pensions (y compris les conjoints survivants) et à tous ceux qui approchent de la retraite. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association du personnel, les documents nécessaires. Nous invitons vivement ces derniers à s’associer à notre groupement en...

GAC-EPA

CERN Multimedia

GAC-EPA

2018-01-01

Le GAC organise des permanences avec entretiens individuels qui se tiennent le dernier mardi de chaque mois, sauf en juillet et décembre. La prochaine permanence se tiendra le : Mardi 27 mars de 13 h 30 à 16 h 00 Salle de réunion de l’Association du personnel Les permanences suivantes auront lieu les mardis 24 avril, 29 mai, 26 juin, 28 août, 25 septembre, 30 octobre et 27 novembre 2018. Les permanences du Groupement des Anciens sont ouvertes aux bénéficiaires de la Caisse de pensions (y compris les conjoints survivants) et à tous ceux qui approchent de la retraite. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association du personnel, les documents nécessaires. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l&am...

GAC-EPA

CERN Multimedia

GAC-EPA

2018-01-01

Le GAC organise des permanences avec entretiens individuels qui se tiennent le dernier mardi de chaque mois, sauf en juillet et décembre. La prochaine permanence se tiendra le : Mardi 27 février de 13 h 30 à 16 h 00 Salle de réunion de l’Association du personnel Les permanences suivantes auront lieu les mardis 27 mars, 24 avril, 29 mai, 26 juin, 28 août, 25 septembre, 30 octobre et 27 novembre 2018. Les permanences du Groupement des Anciens sont ouvertes aux bénéficiaires de la Caisse de pensions (y compris les conjoints survivants) et à tous ceux qui approchent de la retraite. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association du personnel, les documents nécessaires. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, au...

GAC-EPA

CERN Multimedia

GAC-EPA

2018-01-01

Le GAC organise des permanences avec entretiens individuels qui se tiennent le dernier mardi de chaque mois, sauf en juillet et décembre. La prochaine permanence se tiendra le : Mardi 27 mars de 13 h 30 à 16 h 00 Salle de réunion de l’Association du personnel Les permanences suivantes auront lieu les mardis 24 avril, 29 mai, 26 juin, 28 août, 25 septembre, 30 octobre et 27 novembre 2018. Les permanences du Groupement des Anciens sont ouvertes aux bénéficiaires de la Caisse de pensions (y compris les conjoints survivants) et à tous ceux qui approchent de la retraite. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association du personnel, les documents nécessaires. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l&...

GAC-EPA

CERN Multimedia

GAC-EPA

2018-01-01

Le GAC organise des permanences avec entretiens individuels qui se tiennent le dernier mardi de chaque mois, sauf en juillet et décembre. La prochaine permanence se tiendra le : Mardi 24 avril de 13 h 30 à 16 h 00 Salle de réunion de l’Association du personnel Les permanences suivantes auront lieu les mardis 29 mai, 26 juin, 28 août, 25 septembre, 30 octobre et 27 novembre 2018. Les permanences du Groupement des Anciens sont ouvertes aux bénéficiaires de la Caisse de pensions (y compris les conjoints survivants) et à tous ceux qui approchent de la retraite. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association du personnel, les documents nécessaires. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’As...

A quantitative evaluation of the reliability of calculated decay properties of nuclei in the mass region of A=24-28

International Nuclear Information System (INIS)

Timmer, G.A.; Meurders, F.; Brussaard, P.J.; Hienen, J.F.A. van

1978-01-01

Electromagnetic transition rates and log ft values were calculated for transitions between positive-parity states in the A=24-28 mass region. The wave functions used were taken from a previous paper. In general we found satisfactory agreement with experiment. In order to have a measure of the stability of the results against changes in the Hamiltonian a method was developed for assigning errors to calculated transition properties. The renormalized single-particle matrix elements of the E2 and M1 transition operators were determined in a phenomenological way. To this end use was made of the errors just mentioned. It was found that good agreement was obtained with bare-nucleon M1 single-particle matrix elements and a state independent effective isoscalar charge for the E2 operator. Predictions for static moments are given. (orig.) [de

The WHO Collaborating Centre for Research and Control of Schistosomiasis at Niamey, Niger

Directory of Open Access Journals (Sweden)

Chippaux J-P

1997-01-01

Full Text Available The Centre de Recherche sur les Méningites et les Schistosomes (CERMES is a research institute depending on the Organisation de Coordination et de Coopération pour la lutte contre les Grandes Endémies - a West African Organization for Public Health - devoted to the studies on schistosomiasis and meningitis. The staff includes 32 persons with 11 scientists and one financial officer. The activities of the CERMES involving schistosomiasis concern three research units: (a ecology of human and animal schistosomiasis transmission; the CERMES defined the different patterns of schistosomiasis transmission in Niger (involving African dry savana; in this field, we have shown, (i the existence of important variability in conditions of transmission of S. haematobium and, (ii natural hybridization between parasitic species of the ruminants (S. bovis and S. curassoni and genetic interaction between human and animal parasites; (b definition of morbidity indicators usable for rapid assessment methods, for appraisal of the severity of the disease and for the evaluation of the efficiency of control methods; we have established the correlation between ultrasonographic data and some cheap and simple field indicators; (c immune response and protective immunity induced by recombinant glutathion S-transferase (Sm28, Sb28 and Sh28 in homologous and heterologous animal models including goats, sheep and non human primates (Erythrocebus patas. In Niger, we participate in all control programs against schistosomiasis to define control strategies, to supervise operations and to participate in their evaluation with external experts. International collaborations constitute a frame including four laboratories in Africa and six laboratories in developed countries (Europe and USA

40 CFR 407.24 - Pretreatment standards for existing sources.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Pretreatment standards for existing sources. 407.24 Section 407.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED FRUITS AND VEGETABLES PROCESSING POINT SOURCE...

Polarization of {sup 23}Ne, {sup 24m,25}Al and {sup 28}P produced through single nucleon pickup and charge-exchange reactions at 100 AMeV

Energy Technology Data Exchange (ETDEWEB)

Ohtsubo, T., E-mail: tohtsubo@np.gs.niigata-u.ac.jp; Hirano, H.; Takahashi, S. [Niigata Univ. (Japan); Matsuta, K.; Mihara, M.; Fukuda, M. [Osaka Univ. (Japan); Nagatomo, T. [RIKEN (Japan); Izumikawa, T. [Niigata Univ., RI Center (Japan); Momota, S. [Kochi Univ. of Tech. (Japan); Nishimura, D.; Komurasaki, J.; Ishikawa, D. [Osaka Univ. (Japan); Zhou, D. M.; Zheng, Y. N.; Zhu, S. Y. [China Institute of Atomic Energy (China); Kitagawa, A.; Kanazawa, M.; Torikoshi, M.; Sato, S. [Inage-ku, NIRS (Japan); Minamisono, T. [Fukui Univ. of Tech. (Japan)

2007-11-15

We measured the polarization of the {beta}-emitting {sup 23}Ne (I{sup {pi}} 5/2{sup +}, T{sub 1/2} = 37.24 s) and {sup 25}Al(I{sup {pi}} = 5/2{sup +}, T{sub 1/2} = 7.18 s) produced through the one nucleon pickup reactions and {sup 24m}Al(I{sup {pi}} = 1{sup +}, T{sub 1/2} 131 ms, E{sub ex} = 426 keV) and {sup 28}P(I{sup {pi}} = 3{sup +}, T{sub 1/2} = 270 ms) produced through charge-exchange reactions in the intermediate energy heavy ion collisions. We compared them with those from the projectile fragmentation process. The larger polarization seems to persistently be positive throughout the momentum distribution, and sharper momentum distributions suggest that nuclear friction mechanism is responsible for the polarization phenomena.

A study of Gamow-Teller transitions for N = Z nuclei, {sup 24}Mg, {sup 28}Si, and {sup 32}S, by a deformed QRPA

Energy Technology Data Exchange (ETDEWEB)

Ha, Eunja; Cheoun, Myung-Ki [Soongsil University, Origin of Matter and Evolution of Galaxy Institute and Department of Physics, Seoul (Korea, Republic of)

2017-02-15

We investigated Gamow-Teller (GT) transitions and strength distributions of s-d shell N = Z nuclei, {sup 24}Mg, {sup 28}Si, and {sup 32}S, by a deformed quasi-particle random phase approximation (DQRPA). In the DQRPA, we included particle model space up to p-f shell and considered explicitly the deformation as well as the like- and unlike-pairing correlations. Shell evolution by deformation and attractive force by unlike-pairing correlations turned out to play vital roles to reproduce the experimental GT data. Correlations between the deformation and the pairing correlations are also discussed with the comparison to the experimental data shape. (orig.)

Calendrier des activités (juillet 2003 - juin 2004

Directory of Open Access Journals (Sweden)

2003-11-01

Full Text Available 200330 juin-25 juilletAuxerre, Stage : l’archéologie du bâti religieux, l’église Saint-Pierre de Saint-Père (Yonne.3-5 septembreCluny, Déléage, 1903-1944 : fondateur de l’histoire de la société médiévale bourguignonne, Alain Guerreau15-17 septembreDijon, Couleur de temps, fragments d’histoires : peintures murales médiévales, Daniel Russo26-27 septembreAuxerre, Sacralités royales en péninsule ibérique : formes, limites, modalités - VIIe-XVe siècles, Patrick Henriet27-31 octobreSão Paulo. Le M...

27 CFR 28.220 - Notice of return.

Science.gov (United States)

2010-04-01

... OF THE TREASURY LIQUORS EXPORTATION OF ALCOHOL Exportation of Wine With Benefit of Drawback § 28.220 Notice of return. If an exporter desires to return wine to a bonded wine cellar or wholesale liquor... wine cellar from which withdrawn; (b) Date and serial number of the Form 1582-A (5120.24) on which the...

CDC28, NETI, and HFII are required for checkpoints in Saccharomyces cerevisiae

International Nuclear Information System (INIS)

Koltovaya, N.A.; Kadyshevskaya, E.Yu.; Roshina, M.P.; Devin, A.B.

2009-01-01

The involvement of SRM genes selected as genes affecting genetic stability and radiosensitivity in a cell cycle arrest under the action of damaging agents was studied. It was shown that the srm5/cdc28-srm, srm8/netI-srm, and srmI2/hfiI-srm mutations prevent checkpoint activation by DNA damage, particularly the G 0 /S (srm5, srm8), G 1 /S (srm5, srm8, srm12), S (srm8, srm12) and S/G 2 (srm5) checkpoints. It seems that in budding yeast the CDC28, HFII/ADAI, and NETI genes mediate cellular response induced by DNA damage with checkpoint control. The well-known checkpoint-genes RAD9, RAD17, RAD24, and RAD53, and the genes CDC28, and NETI have been found to belong to one epistasis group named RAD9-group as regards cell sensitivity to γ radiation. An analysis of the radiosensitivity of double mutants has revealed that the mutation cdc-28-srm is hypostatic to each of mutations rad9Δ, and rad24Δ, and additive to rad17Δ. The mutation netI-srm is hypostatic to the mutations rad9Δ but additive to rad17Δ, rad24Δ, and rad53. The mutation hfiI-srm has an additive effect in compound with the mutations rad24Δ and rad9Δ. So, investigations of epistatic interactions have demonstrated a branched RAD9-dependent pathway. The analyzed genes can also participate in a minor mechanism involved in determining cell radiation sensitivity independently of the mentioned RAD9-dependent pathway

49 CFR 28.152-28.159 - [Reserved

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false [Reserved] 28.152-28.159 Section 28.152-28.159 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION §§ 28.152-28.159 [Reserved] ...

49 CFR 28.171-28.999 - [Reserved

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false [Reserved] 28.171-28.999 Section 28.171-28.999 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION §§ 28.171-28.999 [Reserved] ...

49 CFR 28.132-28.139 - [Reserved

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false [Reserved] 28.132-28.139 Section 28.132-28.139 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION §§ 28.132-28.139 [Reserved] ...

49 CFR 28.161-28.169 - [Reserved

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2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false [Reserved] 28.161-28.169 Section 28.161-28.169 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION §§ 28.161-28.169 [Reserved] ...

49 CFR 28.141-28.148 - [Reserved

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false [Reserved] 28.141-28.148 Section 28.141-28.148 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION §§ 28.141-28.148 [Reserved] ...

49 CFR 28.104-28.109 - [Reserved

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false [Reserved] 28.104-28.109 Section 28.104-28.109 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION §§ 28.104-28.109 [Reserved] ...

49 CFR 28.112-28.129 - [Reserved

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false [Reserved] 28.112-28.129 Section 28.112-28.129 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION §§ 28.112-28.129 [Reserved] ...

24 CFR 1000.28 - May a self-governance Indian tribe be exempted from the applicability of § 1000.26?

Science.gov (United States)

2010-04-01

... be exempted from the applicability of § 1000.26? 1000.28 Section 1000.28 Housing and Urban... ACTIVITIES General § 1000.28 May a self-governance Indian tribe be exempted from the applicability of § 1000... and systems meet or exceed the comparable requirements of § 1000.26. For purposes of this section, a...

Calendrier des activités (de juillet 2010 à juillet 2011

Directory of Open Access Journals (Sweden)

2010-10-01

Full Text Available Année 20107-8 septembre Sens– Faïences et majoliques, du xve au début du xviie siècle en France, à partir des découvertes archéologiques : pour un bilan des connaissances. Fabienne Ravoire et Alban Horry9-12 septembreCluny– Cluny, le monachisme et l’émergence d’une société seigneuriale (voir programme Bucema 1330 septembre-1er  octobreDijon-Besançon – Le vocabulaire et la rhétorique des comptabilités médiévales. Modèles, innovations, formalisation. Patrice BeckAnnée 201128 janvierDijon– CBMA...

Crystallization and preliminary crystallographic analysis of human Ca2+-loaded calbindin-D28k

International Nuclear Information System (INIS)

Zhang, Chang; Sun, Yuna; Wang, Wei; Zhang, Yan; Ma, Ming; Lou, Zhiyong

2008-01-01

Human calbindin-D28k has been overexpressed in E. coli, purified and crystallized. Diffraction data were collected to 2.4 Å resolution. Calbindin-D28k is a calcium-binding protein that belongs to the troponin C superfamily. It is expressed in many tissues, including brain, intestine, kidney and pancreas, and performs roles as both a calcium buffer and a calcium sensor and carries out diverse physiological functions of importance. In order to resolve the crystal structure of human calbindin-D28k and to gain a better understanding of its biological functions, recombinant human calbindin-D28k was crystallized at 291 K using PEG 3350 as precipitant and a 2.4 Å resolution X-ray data set was collected from a single flash-cooled crystal (100 K). The crystal belonged to space group C2, with unit-cell parameters a = 108.1, b = 28.2, c = 70.6 Å, β = 107.8°. The presence of one molecule per asymmetric unit is presumed, corresponding to a Matthews coefficient of 1.75 Å 3 Da −1

28 CFR 0.28 - General functions.

Science.gov (United States)

2010-07-01

... Affairs § 0.28 General functions. The Office of Public Affairs is headed by a Director of Public Affairs who shall: (a) Handle matters pertaining to relations with the public generally. (b) Disseminate... 28 Judicial Administration 1 2010-07-01 2010-07-01 false General functions. 0.28 Section 0.28...

Crystallization and preliminary crystallographic analysis of human Ca{sup 2+}-loaded calbindin-D28k

Energy Technology Data Exchange (ETDEWEB)

Zhang, Chang [Tsinghua-Nankai-IBP Joint Research Group for Structural Biology, Tsinghua University, Beijing 100084 (China); Sun, Yuna [National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing 100101 (China); Wang, Wei; Zhang, Yan [Tsinghua-Nankai-IBP Joint Research Group for Structural Biology, Tsinghua University, Beijing 100084 (China); Ma, Ming [National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing 100101 (China); Lou, Zhiyong, E-mail: louzy@xtal.tsinghua.edu.cn [Tsinghua-Nankai-IBP Joint Research Group for Structural Biology, Tsinghua University, Beijing 100084 (China)

2008-02-01

Human calbindin-D28k has been overexpressed in E. coli, purified and crystallized. Diffraction data were collected to 2.4 Å resolution. Calbindin-D28k is a calcium-binding protein that belongs to the troponin C superfamily. It is expressed in many tissues, including brain, intestine, kidney and pancreas, and performs roles as both a calcium buffer and a calcium sensor and carries out diverse physiological functions of importance. In order to resolve the crystal structure of human calbindin-D28k and to gain a better understanding of its biological functions, recombinant human calbindin-D28k was crystallized at 291 K using PEG 3350 as precipitant and a 2.4 Å resolution X-ray data set was collected from a single flash-cooled crystal (100 K). The crystal belonged to space group C2, with unit-cell parameters a = 108.1, b = 28.2, c = 70.6 Å, β = 107.8°. The presence of one molecule per asymmetric unit is presumed, corresponding to a Matthews coefficient of 1.75 Å{sup 3} Da{sup −1}.

Diversité floristique des épiphytes et hémiparasites vasculaires de l ...

African Journals Online (AJOL)

SARAH

30 sept. 2017 ... septembre sont en partie secs, entrainant une stabilité de l'air (Vennetier, 1977) ; (iii) une saison sèche et fraîche de juin à septembre, qui alterne avec une saison humide et chaude allant d'octobre à mai (Vennetier, 1977) ; (iv) l'humidité relative est particulièrement élevée, toujours supérieure à 70 %.

EBT-S 28-GHz, 200-kW, CW, mixed-mode, quasi-optical plasma heating system

International Nuclear Information System (INIS)

White, T.L.; Kimrey, H.D.; Bigelow, T.S.; Bates, D.D.; Eason, H.O.

1984-07-01

The ELMO Bumpy Torus-Scale (EBT-S) 28-GHz, 200-kW, cw, plasma heating system consists of a gyrotron oscillator, an oversized waveguide two-bend transmission system, and a quasi-optical mixed-mode microwave distribution manifold that feeds microwave power to the 24 plasma loads of the EBT-S fusion experiment. Balancing power to the 24 loads of the EBT-S fusion experiment. Balancing power to the 24 loads was achieved by adjusting the areas at 24 coupling irises. System performance is easily measured using system calorimetry. The distribution manifold mixed-mode power transmission, reflection, and loss coefficients are 89%, 6%, and 5%, respectively. The overall system efficiency (plasma power/gyrotron power) is 80%, but with some modifications to the distribution manifold we believe the ultimate efficiency can approach 90%. The system reliability is outstanding with a world's record 1 x 10 5 kW h of 28-GHz energy delivered to the EBT-S device with well over 1 x 10 3 operating hours

DILEPTON YIELD FROM THE DECAY OF EXCITED SI-28 STATES

NARCIS (Netherlands)

BACELAR, JC; BUDA, A; BALANDA, A; KRASZNAHORKAY, A; VANDERPLOEG, H; SUJKOWSKI, Z; VANDERWOUDE, A

1994-01-01

The first dilepton yield measurements from excited nuclear states obtained with a new Positron-Electron Pair Spectroscopic Instrument (PEPSI) are reported. Nuclear states in Si-28, with an initial excitation energy E* = 50 MeV, were populated via the isospin T = 0 reaction He-4 + Mg-24 and the

Study of the 28Si(16O,20Ne)24Mg reaction

International Nuclear Information System (INIS)

Portezan Filho, O.

1988-01-01

In this work, measurements of elastic and inelastic angular distributions in the system 16 O+ 20 Si and in the alpha transfer reactions 20 Si( 16 O, 20 Ne) 24 Mg were made in the angular range of 20 0 0 and the transfer reaction 20 Si( 16 O, 12 C) 32 S in the angular range 16 0 0 at the energy of E cm = 31.57 MeV. Optical potential parameters and β 2 deformation parameters as well as spectroscopic factors were determined for the alpha transfer reactions. (A.C.A.S.) [pt

GAC-EPA

CERN Multimedia

GAC-EPA

2017-01-01

Le GAC organise des permanences avec entretiens individuels qui se tiennent le dernier mardi de chaque mois, sauf en juin, juillet et décembre. La prochaine permanence se tiendra le : Mardi 31 janvier de 13 h 30 à 16 h 00 Salle de réunion de l’Association du personnel Les permanences suivantes auront lieu les mardis 28 février, 28 mars, 25 avril, 30 mai, 29 août, 26 septembre, 31 octobre et 28 novembre 2017. Les permanences du Groupement des Anciens sont ouvertes aux bénéficiaires de la Caisse de pensions (y compris les conjoints survivants) et à tous ceux qui approchent de la retraite. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association du personnel, les documents nécessaires. Informations : http://gac-epa.org/. e-mail : gac-epa@gac-epa.org.

GAC-EPA

CERN Multimedia

GAC-EPA

2017-01-01

Le GAC organise des permanences avec entretiens individuels qui se tiennent le dernier mardi de chaque mois, sauf en juin, juillet et décembre. La prochaine permanence se tiendra le : Mardi 28 février de 13 h 30 à 16 h 00 Salle de réunion de l’Association du personnel Les permanences suivantes auront lieu les mardis 28 mars, 25 avril, 30 mai, 29 août, 26 septembre, 31 octobre et 28 novembre 2017. Les permanences du Groupement des Anciens sont ouvertes aux bénéficiaires de la Caisse de pensions (y compris les conjoints survivants) et à tous ceux qui approchent de la retraite. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association du personnel, les documents nécessaires. Informations : http://gac-epa.org/. Formulaire de contact : http://gac-epa.org/Organization/ContactForm/ContactForm-fr.php

Utilization of potatoes for life support systems. II - The effects of temperature under 24-h and 12-h photoperiods

Science.gov (United States)

Wheeler, Raymond M.; Steffen, Kenneth L.; Tibbitts, Theodore W.; Palta, Jiwan P.

1986-01-01

The effects of temperature and the photoperiod length on the growth and tuberization of Norland potatoes were investigated for two photoperiods, 12-h and 24-hr at 400 micromol/sq m per sec PPF, and at temperatures of 12, 16, 20, 24, and 28 C. It was found that stem length increased with increasing temperature under both photoperiods. The highest tuber yield was obtained at 16 C under the 24-hr photoperiod and at 20 C under the 12-hr photoperiod (i.e., increasing the photoperiod from 12 to 24 hrs effectively decreases the optimal temperature for tuber formation). Little or no tuber formation occurred at 28 C under either photoperiod.

Two uranium mines in Niger: Somair Cominak

International Nuclear Information System (INIS)

Caleix, C.; Renardet, P.

1987-01-01

The research work undertaken by the Atomic Energy Commission on the territory of the Republic of the Niger has led to the discovery of two major uranium deposits, Arlit and Akouta, which are situated at the of the Sahara to the West of the massif of l'Air at approximately 850 km from Niamey. These deposits are exploited by two firms according to Nigerian law with a head office at Niamey. The firm Somair acts for Arlit and operates an open pit; the mining company Akouta works the Akouta deposit which is deeper and entails an underground operation. The production capacities are 2300 t and 2000 t of uranium metal per year, respectively [fr

Mooste näitemängu lugu läbi aastate 1. - 28. / Karl Pilvistu

Index Scriptorium Estoniae

Pilvistu, Karl

1998-01-01

Alates 24. sept. pealkiri 'Mooste külateatri lugu läbi aastate'. Järg: 30. apr. ; 7., 14., 21. ja 28. mai ; 6., 11., 18. ja 27. juuni ; 2., 9., 16. ja 25. juuli ; 6. ja 15. aug. ; 10., 24. ja 26. sept. ; 10., 15., 17. ja 29. okt. ; 5., 12. nov. ; 3., 10., 12. dets.

Electronic structure of C28, Pa at sign C28, and U at sign C28

International Nuclear Information System (INIS)

Zhao, K.; Pitzer, R.M.

1996-01-01

Electronic structure calculations, including relativistic core potentials and the spin-orbit interaction, have been carried out on the C 28 , Pa at sign C 28 , and U at sign C 28 species. Excitation energies, spin-orbit splittings, the electron affinity, and the ionization potential are computed for C 28 . The ground state of C 28 is described well by the Hartree-Fock wave functions, but other states are not. The computed electron affinity and ionization potential are similar to those of C 60 . Strong metal-cage binding is found for Pa at sign C 28 and U at sign C 28 , similar to that in U(C 8 H 8 ) 2 . The ground electronic states depend on the order of the lowest-energy cage π * and metal 5f orbitals, with (π * ) 1 and (π * ) 1 (5f) 1 found to be the ground electronic configurations for the two complexes. U at sign C 28 is found to be diamagnetic. 30 refs., 1 fig., 13 tabs

Proceedings of the XXXI International Meeting on Fundamental Physics. B-Physics, Astroparticle Physics and Neutrino Physics. Soto de Cangas, Asturias, spain, 24-28 February, 2003

International Nuclear Information System (INIS)

2004-01-01

The XXXIth International Meeting on Fundamental Physics was held in La Pasera Resort at soto de Cangas (Asturias, Spain) from February 24-28, 2003. The meeting was devoted to experimental and theoretical issues of high energy physics, with special reference to beauty physics, astroparticle and neutrino physics. The major topics, as well as some special talks on Fundamental Physics at Low Energy Experiments and computing for the new era of High Energy Physics Experiments, were developed in a series of course lectures. Short contributions concerning the state of the art in those topics, as well as the last LEP results, and medical applications of the high energy detector developments, were also given. The meeting was sponsored by the Ministerio de Ciencia y Tecnologia, the Consejo Superior de Investigaciones Cientificas, the Universidades de Cantabria y Oviedo, the Principado de Asturias and the Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas. (Author)

The key role of U{sub 28} in the aqueous self-assembly of uranyl peroxide nanocages

Energy Technology Data Exchange (ETDEWEB)

Falaise, Clement; Nyman, May [Energy Frontier Research Center, Materials Science of Actinides, Department of Chemistry, Oregon State University, Corvallis, OR (United States)

2016-10-04

For 11 years now, the structural diversity and aesthetic beauty of uranyl-peroxide capsules have fascinated researchers from the diverse fields of mineralogy, polyoxometalate chemistry, and nuclear fuel technologies. There is still much to be learned about the mechanisms of the self-assembly process, and the role of solution parameters including pH, alkali template, temperature, time, and others. Here we have exploited the high solubility of the UO{sub 2}{sup 2+}/H{sub 2}O{sub 2}/LiOH aqueous system to address the effect of the hydroxide concentration. Important techniques of this study are single-crystal X-ray diffraction, small-angle X-ray scattering, and Raman spectroscopy. Three key phases dominate the solution speciation as a function of time and the LiOH/UO{sub 2}{sup 2+} ratio: the uranyl-triperoxide monomer [UO{sub 2}(O{sub 2}){sub 3}]{sup 4-}and the two capsules [(UO{sub 2})(O{sub 2})(OH)]{sub 24}{sup 24-}(U{sub 24}) and [(UO{sub 2})(O{sub 2}){sub 1.5}]{sub 28}{sup 28-}(U{sub 28}). When the LiOH/U ratio is around three, U{sub 28} forms rapidly and this cluster can be isolated in high yield and purity. This result was most surprising and challenges the hypothesis that alkali templating is the most important determinant in the cluster geometry. Moreover, analogous experiments with KOH, NH{sub 4}OH, and TEAOH (TEA=tetraethylammonium) also rapidly yield U{sub 28}, which suggests that U{sub 28} is the kinetically favored species. Complete mapping of the pH-time phase space reveals only a narrow window of the U{sub 28} dominance, which is why it was previously overlooked as an important kinetic species in this chemical system, as well as others with different counterions. (copyright 2016 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

28 CFR 28.12 - Collection of DNA samples.

Science.gov (United States)

2010-07-01

... Homeland Security, collecting DNA samples from: (1) Aliens lawfully in, or being processed for lawful... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Collection of DNA samples. 28.12 Section 28.12 Judicial Administration DEPARTMENT OF JUSTICE DNA IDENTIFICATION SYSTEM DNA Sample Collection...

TH28 (Krautter's star) and its string of Herbig-Haro objects

International Nuclear Information System (INIS)

Graham, J.A.; Heyer, M.H.

1988-01-01

A high-quality spectrogram of the unusual T Tauri-like star Th28 and its string of Herbig-Haro (HH) objects has been obtained. New velocities and line intensities for the star and the gaseous knots are reported, and data are given for a third HH object located 87 arcsec to the SE along the same collimation axis as defined by the other features. Th28 has a heliocentric velocity of +5 km/s which is close to the velocity of the CO in the area. The star's spectral type is probably in the G8-K2 range. 24 references

29 August 2013 - J.-F. Jauslin, Directeur de l’Office fédéral de la culture (OFC) Ambassadeur suisse auprès de l’UNESCO et de l’OIF au 1er septembre 2013 Confédération suisse visite le centre visiteurs de l’expérience ATLAS ainsi que la caverne expérimentale d'ATLAS avec P. Jenny, ancien Porte-parole d'ATLAS. M. Bona, Conseiller du Directeur général pour les relations avec les Organisations internationales présent tout au long.

CERN Multimedia

Jean-Claude Gadmer

2013-01-01

29 August 2013 - J.-F. Jauslin, Directeur de l’Office fédéral de la culture (OFC) Ambassadeur suisse auprès de l’UNESCO et de l’OIF au 1er septembre 2013 Confédération suisse visite le centre visiteurs de l’expérience ATLAS ainsi que la caverne expérimentale d'ATLAS avec P. Jenny, ancien Porte-parole d'ATLAS. M. Bona, Conseiller du Directeur général pour les relations avec les Organisations internationales présent tout au long.

Early Childhood in Central and Eastern Europe: Issues and Challenges. Action Research in Family and Early Childhood. UNESCO Education Sector Monograph No. 13/2000. First Central and Eastern European Early Childhood Care and Development Meeting (Budapest, Hungary, October 24-28, 1999).

Science.gov (United States)

Korintus, Marta

This document is comprised of the proceedings from the first Central and Eastern European Early Childhood Care and Development (ECCD) meeting in Budapest, Hungary, October 24-28, 1999, convened to begin the development of an ECCD network in the region to address the similar needs and concerns of children in these countries. Following an…

Dissolved inorganic carbon, pH, alkalinity, temperature, salinity and other variables collected from discrete sample and profile observations using CTD, Coulometer for DIC measurement and other instruments from the MIRAI in the North Pacific Ocean from 2005-02-28 to 2005-03-24 (NODC Accession 0112264)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0112264 includes chemical, discrete sample, physical and profile data collected from MIRAI in the North Pacific Ocean from 2005-02-28 to 2005-03-24...

VizieR Online Data Catalog: 24um excesses in clusters & membership of NGC2244 (Meng+, 2017)

Science.gov (United States)

Meng, H. Y. A.; Rieke, G. H.; Su, K. Y. L.; Gaspar, A.

2017-09-01

We re-measured the Spitzer/MIPS 24um photometry for all the clusters except for a few noted in Appendix A. We obtained the 24um data from the Spitzer Heritage Archive between 2004 Jan 28 and 2008 Oct 23. (3 data files).

28 CFR 68.28 - Authority of Administrative Law Judge.

Science.gov (United States)

2010-07-01

....28 Section 68.28 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) RULES OF PRACTICE AND... UNLAWFUL EMPLOYMENT OF ALIENS, UNFAIR IMMIGRATION-RELATED EMPLOYMENT PRACTICES, AND DOCUMENT FRAUD § 68.28... so, any pertinent book, paper, or document, or refuses to appear after having been subpoenaed, or...

24 CFR 84.20 - Purpose of financial and program management.

Science.gov (United States)

2010-04-01

... and Program Management § 84.20 Purpose of financial and program management. Sections 84.21 through 84.28 prescribe standards for financial management systems, methods for making payments and rules for... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Purpose of financial and program...

24 - 28_Suleiman et al.

African Journals Online (AJOL)

User

larval instar. Keywords: Antlion, Construction, Density, Distribution, Hunger, Larvae, Pit. INTRODUCTION ... 1987), moisture (Gotelli 1993; Morrison 1994), and shade (scharfet al. .... Pit building was virtually the same in all three instar, and no ...

24 - 28_Suleiman et al.

African Journals Online (AJOL)

User

from their constructed pits under trees within Biological .... *Pairs of treatments that are not significantly different from one another share the same letter a, b or c at 10% ... 4.5a. M. 7.9 b. 2.9 a. 4.9a. *Pairs of treatments that are not significantly different from one another share .... and luminance on predator foraging decision.

SEARCH FOR PULSED {gamma}-RAY EMISSION FROM GLOBULAR CLUSTER M28

Energy Technology Data Exchange (ETDEWEB)

Wu, J. H. K.; Kong, A. K. H.; Huang, R. H. H.; Tam, P. H. T. [Institute of Astronomy and Department of Physics, National Tsing Hua University, Hsinchu, Taiwan (China); Hui, C. Y. [Department of Astronomy and Space Science, Chungnam National University, Daejeon (Korea, Republic of); Wu, E. M. H.; Takata, J.; Cheng, K. S., E-mail: wuhkjason@gmail.com, E-mail: cyhui@cnu.ac.kr [Department of Physics, University of Hong Kong, Pokfulam Road (Hong Kong)

2013-03-10

Using the data from the Large Area Telescope on board the Fermi Gamma-ray Space Telescope, we have searched for {gamma}-ray pulsations from the direction of the globular cluster M28 (NGC 6626). We report the discovery of a signal with a frequency consistent with that of the energetic millisecond pulsar (MSP) PSR B1821-24 in M28. A weighted H-test test statistic of 28.8 is attained, which corresponds to a chance probability of {approx}10{sup -5} (4.3{sigma} detection). With a phase-resolved analysis, the pulsed component is found to contribute {approx}25% of the total observed {gamma}-ray emission from the cluster. However, the unpulsed level provides a constraint for the underlying MSP population and the fundamental plane relations for the scenario of inverse Compton scattering. Follow-up timing observations in radio/X-ray are encouraged to further investigate this periodic signal candidate.

9th Mining and metallurgy international congress, Leon, 24-28 May 1994

International Nuclear Information System (INIS)

1994-01-01

The 9th Mining and Metallurgy International Congress had 201 communications. These was articulated into 4th areas: 1.- Geological resources management and profit: 1.1- Geological and mining research on geologic resources. 1.2.- Non energetic mineral resources exploitation. 1.3- Hydro-geologic and geothermia resources. 1.4- Geologic resources and planning. 2.- Energy: 2.1.- Energetic mining.- 2.2 Oil and gas. 2.3.- Electricity production and distribution. 2.4.- Coal clean technologies. 2.5.- Energetic management. 3.- Material engineering: 3.1.- Minerallurgia and metallurgic processes. 3.2- Industrial minerals and ornamental 10cks. 3.3 .- Building materials. 3.4 Advanced technology materials. 4.- Environmental and territorial engineering in basic industry. 4.1.-Valuation of environmental impacts. 4.2.- Restoration engineering in mining. 4.3.- Effluent and residue engineering. 4.4.- Environmental management and clean technologies 4.5.- Natural and technological risks

POSITRON-ELECTRON DECAY OF SI-28, AT AN EXCITATION-ENERGY OF 50-MEV

NARCIS (Netherlands)

BUDA, A; BACELAR, JC; BALANDA, A; VANDERPLOEG, H; SUJKOWSKI, Z; VANDERWOUDE, A

1993-01-01

The electron-positron pair decay of Si-28 at 50 MeV excitation produced by the isospin T=0 (alpha + Mg-24) and the mixed isospin T=0,1 (He-3 + Mg-25) reactions has been studied using a special designed Positron-Electron pair spectrometer PEPSI.

TBC1D24 genotype–phenotype correlation

Science.gov (United States)

Balestrini, Simona; Milh, Mathieu; Castiglioni, Claudia; Lüthy, Kevin; Finelli, Mattea J.; Verstreken, Patrik; Cardon, Aaron; Stražišar, Barbara Gnidovec; Holder, J. Lloyd; Lesca, Gaetan; Mancardi, Maria M.; Poulat, Anne L.; Repetto, Gabriela M.; Banka, Siddharth; Bilo, Leonilda; Birkeland, Laura E.; Bosch, Friedrich; Brockmann, Knut; Cross, J. Helen; Doummar, Diane; Félix, Temis M.; Giuliano, Fabienne; Hori, Mutsuki; Hüning, Irina; Kayserili, Hulia; Kini, Usha; Lees, Melissa M.; Meenakshi, Girish; Mewasingh, Leena; Pagnamenta, Alistair T.; Peluso, Silvio; Mey, Antje; Rice, Gregory M.; Rosenfeld, Jill A.; Taylor, Jenny C.; Troester, Matthew M.; Stanley, Christine M.; Ville, Dorothee; Walkiewicz, Magdalena; Falace, Antonio; Fassio, Anna; Lemke, Johannes R.; Biskup, Saskia; Tardif, Jessica; Ajeawung, Norbert F.; Tolun, Aslihan; Corbett, Mark; Gecz, Jozef; Afawi, Zaid; Howell, Katherine B.; Oliver, Karen L.; Berkovic, Samuel F.; Scheffer, Ingrid E.; de Falco, Fabrizio A.; Oliver, Peter L.; Striano, Pasquale; Zara, Federico

2016-01-01

Objective: To evaluate the phenotypic spectrum associated with mutations in TBC1D24. Methods: We acquired new clinical, EEG, and neuroimaging data of 11 previously unreported and 37 published patients. TBC1D24 mutations, identified through various sequencing methods, can be found online (http://lovd.nl/TBC1D24). Results: Forty-eight patients were included (28 men, 20 women, average age 21 years) from 30 independent families. Eighteen patients (38%) had myoclonic epilepsies. The other patients carried diagnoses of focal (25%), multifocal (2%), generalized (4%), and unclassified epilepsy (6%), and early-onset epileptic encephalopathy (25%). Most patients had drug-resistant epilepsy. We detail EEG, neuroimaging, developmental, and cognitive features, treatment responsiveness, and physical examination. In silico evaluation revealed 7 different highly conserved motifs, with the most common pathogenic mutation located in the first. Neuronal outgrowth assays showed that some TBC1D24 mutations, associated with the most severe TBC1D24-associated disorders, are not necessarily the most disruptive to this gene function. Conclusions: TBC1D24-related epilepsy syndromes show marked phenotypic pleiotropy, with multisystem involvement and severity spectrum ranging from isolated deafness (not studied here), benign myoclonic epilepsy restricted to childhood with complete seizure control and normal intellect, to early-onset epileptic encephalopathy with severe developmental delay and early death. There is no distinct correlation with mutation type or location yet, but patterns are emerging. Given the phenotypic breadth observed, TBC1D24 mutation screening is indicated in a wide variety of epilepsies. A TBC1D24 consortium was formed to develop further research on this gene and its associated phenotypes. PMID:27281533

Roymillerite, Pb24Mg9(Si9AlO28)(SiO4)(BO3)(CO3)10(OH)14O4, a new mineral: mineralogical characterization and crystal chemistry

Science.gov (United States)

Chukanov, Nikita V.; Jonsson, Erik; Aksenov, Sergey M.; Britvin, Sergey N.; Rastsvetaeva, Ramiza K.; Belakovskiy, Dmitriy I.; Van, Konstantin V.

2017-11-01

The new mineral roymillerite Pb24Mg9(Si9AlO28)(SiO4)(BO3)(CO3)10(OH)14O4, related to britvinite and molybdophyllite, was discovered in a Pb-rich assemblage from the Kombat Mine, Grootfontein district, Otjozondjupa region, Namibia, which includes also jacobsite, cerussite, hausmannite, sahlinite, rhodochrosite, barite, grootfonteinite, Mn-Fe oxides, and melanotekite. Roymillerite forms platy single-crystal grains up to 1.5 mm across and up to 0.3 mm thick. The new mineral is transparent, colorless to light pink, with a strong vitreous lustre. Cleavage is perfect on (001). Density calculated using the empirical formula is equal to 5.973 g/cm3. Roymillerite is optically biaxial, negative, α = 1.86(1), β ≈ γ = 1.94(1), 2 V (meas.) = 5(5)°. The IR spectrum shows the presence of britvinite-type tetrahedral sheets, {CO}3^{2 - }, {BO}3^{3 - }, and OH- groups. The chemical composition is (wt%; electron microprobe, H2O and CO2 determined by gas chromatography, the content of B2O3 derived from structural data): MgO 4.93, MnO 1.24, FeO 0.95, PbO 75.38, B2O3 0.50, Al2O3 0.74, CO2 5.83, SiO2 7.90, H2O 1.8, total 99.27. The empirical formula based on 83 O atoms pfu (i.e. Z = 1) is Pb24.12Mg8.74Mn1.25Fe0.94B1.03Al1.04C9.46Si9.39H14.27O83. The crystal structure was determined using single-crystal X-ray diffraction data. The new mineral is triclinic, space group P \\bar{1}, with a = 9.315(1), b = 9.316(1), c = 26.463(4) Å, α = 83.295(3)°, β = 83.308(3)°, γ = 60.023(2)°, V = 1971.2(6) Å3. The crystal structure of roymillerite is based built by alternating pyrophyllite-type TOT-modules Mg9(OH)8[(Si,Al)10O28] and I-blocks Pb24(OH)6O4(CO3)10(BO3,SiO4). The strongest lines of the powder X-ray diffraction pattern [ d, Å (I, %) ( hkl)] are: 25.9 (100) (001), 13.1 (11) (002), 3.480 (12) (017, 107, -115, 1-15), 3.378 (14) (126, 216), 3.282 (16) (-2-15, -1-25), 3.185 (12) (-116, 1-16), 2.684 (16) (031, 301, 030, 300, 332, -109, 0-19, 1-18), 2.382 (11) (0.0.-11). Roymillerite is

Positron-electron decay of 28Si at an excitation energy of 50 MeV

International Nuclear Information System (INIS)

Buda, A.; Bacelar, J.C.; Balanda, A.; Ploeg, H. van der; Sujkowski, Z.; Woude, A. van der

1993-01-01

The electron-positron pair decay of 28 Si at 50 MeV excitation produced by the isospin T=0 (α+ 24 Mg) and the mixed isospin T=0, 1 ( 3 He+ 25 Mg) reactions has been studied using a special designed Positron-Electron pair spectrometer PEPSI. (orig.)

IL-28 and IL-29 as protective markers in subject with dengue fever.

Science.gov (United States)

Hung, Chih-Hsing; Huang, Chung-Hao; Wang, Lin; Huang, Chun-Chi; Wu, Meng-Chieh; Chin, Yi-Ying; Lin, Chun-Yu; Chang, Ko; Wu, Deng-Chyang; Chen, Yen-Hsu

2017-06-01

About 400 million people every year are estimated to contract dengue virus infection, which causes prolonged morbidity and sometimes mortality. Interleukin (IL)-28 and IL-29 are relatively newly discovered cytokines and play an important role in our immune defense against pathogens, especially for viral infection. In the present study, we investigated serum IL-28 and IL-29 expression and the relationship to clinical and laboratory parameters in patients with dengue virus infection. Adult patients with dengue (n = 45) and control group (n = 24) were included prospectively. Clinical symptoms and laboratory data were collected from every patient. We investigated IL-28 and IL-29 levels in serum by ELISA. The concentrations of serum IL-28 and IL-29 were significantly higher in subjects with dengue when compared to those of control group. The patients with higher serum IL-28 and IL-29 levels had significantly lower ALAT and peripheral blood neutrophil percentage, but higher peripheral platelet, total white blood cell (WBC), monocyte, and lymphocyte counts. Patients with higher serum IL-28 and IL-29 levels also had more flu-like symptoms, but less vomiting. Increased level of IL-28 and IL-29 was associated with better liver function, platelet and WBC numbers and clinical symptom in subjects with dengue and could potentially serve as a protective marker.

Bonding properties of FCC-like Au ₄₄ (SR) ₂₈ clusters from X-ray absorption spectroscopy

Energy Technology Data Exchange (ETDEWEB)

Yang, Rui [Department of Chemistry, Dalhousie University, Halifax, NS B3H 4R2, Canada.; Chevrier, Daniel M. [Department of Chemistry, Dalhousie University, Halifax, NS B3H 4R2, Canada.; Zeng, Chenjie [Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213, USA.; Jin, Rongchao [Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213, USA.; Zhang, Peng [Department of Chemistry, Dalhousie University, Halifax, NS B3H 4R2, Canada.

2017-11-01

Thiolate-protected gold clusters with precisely controlled atomic composition have recently emerged as promising candidates for a variety of applications because of their unique optical, electronic, and catalytic properties. The recent discovery of the Au44(SR)28 total structure is considered as an interesting finding in terms of the face-centered cubic (FCC)-like core structure in small gold-thiolate clusters. Herein, the unique bonding properties of Au44(SR)28 is analyzed using temperature-dependent X-ray absorption spectroscopy (XAS) measurements at the Au L3-edge and compared with other FCC-like clusters such as Au36(SR)24 and Au28(SR)20. A negative thermal expansion was detected for the Au–Au bonds of the metal core (the first Au–Au shell) and was interpreted based on the unique Au core structure consisting of the Au4 units. EXAFS fitting results from Au28(SR)20, Au36(SR)24, and Au44(SR)28 show a size-dependent negative thermal expansion behavior in the first Au–Au shell, further highlighting the importance of the Au4 units in determining the Au core bonding properties and shedding light on the growth mechanism of these FCC-like Au clusters.

Therapeutic intervention scoring system-28 (TISS-28: diretrizes para aplicação Therapeutic intervention scoring system-28 (tiss-28: directrices para su aplicación Therapeutic intervention scoring system-28 (tiss-28: directions for application

Directory of Open Access Journals (Sweden)

Katia Grillo Padilha

2005-06-01

Full Text Available O Therapeutic Intervention Scoring System-28 (TISS-28 é um instrumento que permite dimensionar carga de trabalho de enfermagem em Unidade de Terapia Intensiva e estimar gravidade da doença. Apresenta-se nesta publicação as definições operacionais para sua aplicação, proposta por um grupo de especialistas na área, com vistas a uniformizar o significado de cada um dos itens e evitar vieses de interpretação.El Therapeutic Intervention Scoring System-28 (TISS-28 es un instrumento que permite dimensionar carga de trabajo de enfermería en una Unidad de Terapia Intensiva y estimar la gravedad de la enfermedad. Se presenta en esta publicación las definiciones operacionales para su aplicación, propuesta por un grupo de especialistas en el área, con vistas a uniformizar el significado de cada uno de los items y evitar sesgos de interpretación.Therapeutic Intervention Scoring System-28 (TISS-28 is a tool that enables the measurement of the nursing work load in Intensive Care Units and the estimate of how grave the disease is. In this study are presented the operational definitions for its application, proposed by a group of specialists in the area, with the aim of rendering uniform the meaning of each of the items and preventing interpretation biases.

Letter to the editors

African Journals Online (AJOL)

18 nov. 2012 ... Key words: Tramadol, Addiction, Mésusage, Adolescents, Niamey, Niger. Received: ... de préciser les données médicales et sociales. ... Published in partnership with the African Field Epidemiology Network (AFENET).

Risque lié au bruit - French version only

CERN Multimedia

2003-01-01

Nous vous proposons une 1/2 journée de sensibilisation sur les risques concernant les postes de travail exposés à des forts niveaux sonores et les moyens pour s'en protéger. Prochaine session le mercredi 24 septembre 2003. Les cours en français, sont pris en charge par la division TIS et animés par Jacques Coillard du Bureau Véritas. L'inscription est obligatoire. Pour plus d'information et inscription par EDH à ce cours, veuillez consulter les pages des formations en sécurité, ou contacter l'organisateur. Organisateur : Ana-Paula Bernardes/TIS-GS (71385) Ana-paula.bernardes@cern.ch

Circulating CD8+CD28- suppressor T cells tied to poorer prognosis among metastatic breast cancer patients receiving adoptive T-cell therapy: A cohort study.

Science.gov (United States)

Song, Qingkun; Ren, Jun; Zhou, Xinna; Wang, Xiaoli; Song, Guohong; Hobeika, Amy; Yuan, Yanhua; Lyerly, Herbert Kim

2018-01-01

This study aimed to determine the prognostic value of circulating CD8 + CD28 - T lymphocytes among breast cancer patients treated with adoptive T-lymphocyte immunotherapy after chemotherapy. Two hundred and thirty-two breast cancer patients underwent adoptive T-cell immunotherapy. Circulating CD8 + CD28 - proportion was measured by flow cytometry. Median proportion of CD8 + CD28 - was 24.2% and set as the categorical cutoff value for further analysis. The median survival was estimated by Kaplan-Meier curve, with difference detection and hazard ratio estimation by log-rank test and Cox hazard proportion regression model. With adoptive T-cell therapy, patients with higher CD8 + CD28 - levels experienced median progression-free and overall survival of 7.1 months and 26.9 months, respectively-significantly shorter than patients with lower levels (11.8 and 36.2 months). CD8 + CD28 - proportion >24.2% demonstrated a hazard ratio (HR) of 2.06 (95% confidence interval [CI] 1.31-3.12) for progression and an HR of 1.97 (95% CI 1.06-3.67) for death. Among patients who had received previous first-line chemotherapy, CD8 + CD28 - proportion >24.2% demonstrated an HR of 2.66 (95% CI 1.45-4.88) for progression. Among patients exposed to previous second-line or higher chemotherapy, CD8 + CD28 - proportion >24.2% demonstrated a 486% higher risk for death (HR = 5.86, 95% CI 1.77-19.39). A 1% increase in suppressive T cells was associated with a 5% increased risk of death. Elevated peripheral blood CD8 + CD28 - was associated with poorer prognosis for metastatic breast cancer, especially for higher risk of progression among patients with first-line chemotherapy and higher risk of death among patients with more than second-line chemotherapy. Copyright © 2017 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

Profil hormonal chez l'homme en cas d'infertilité au laboratoire de ...

African Journals Online (AJOL)

... d'infertilité au laboratoire de radio immunologie de l'institut des radioisotopes de Niamey. ... Patients and methods: We included in our study, all patients presenting with infertility dating back at leasttwo years, with abnormal semen analysis.

GAC-EPA

CERN Multimedia

GAC-EPA

2017-01-01

Le GAC organise des permanences avec entretiens individuels qui se tiennent le dernier mardi de chaque mois, sauf en juin, juillet et décembre. La prochaine permanence se tiendra le : Mardi 28 mars de 13 h 30 à 16 h 00 Salle de réunion de l’Association du personnel Les permanences suivantes auront lieu les mardis 25 avril, 30 mai, 29 août, 26 septembre, 31 octobre et 28 novembre 2017. Les permanences du Groupement des Anciens sont ouvertes aux bénéficiaires de la Caisse de pensions (y compris les conjoints survivants) et à tous ceux qui approchent de la retraite. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association du personnel, les documents nécessaires. Informations : http://gac-epa.org/. Formulaire de contact : http://gac-epa.org/Organization/ContactForm/ContactForm-fr.php

28 CFR 16.28 - Procedure in the event of an adverse ruling.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Procedure in the event of an adverse ruling. 16.28 Section 16.28 Judicial Administration DEPARTMENT OF JUSTICE PRODUCTION OR DISCLOSURE OF MATERIAL OR INFORMATION Production or Disclosure in Federal and State Proceedings § 16.28 Procedure in the...

Léon Van Hove, 1924-1990

CERN Multimedia

1991-01-01

A la suite de la mort le 2 septembre de Léon Van Hove (septembre/octo- bre, page VII), théoricien distingué et ancien directeur général pour la recherche du CERN, des éloges continuent de nous parvenir du monde entier. Le Courrier CERN a grandement bénéficié de sa sagesse et de son jugement et il convenait que nous publiions quelques témoignages que nous avons spécialement demandés pour illustrer ses multiples talents. Nous remercions André Martin qui a bien voulu coordonner ces contributions.

50 CFR 635.24 - Commercial retention limits for sharks and swordfish.

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Commercial retention limits for sharks and... Management Measures § 635.24 Commercial retention limits for sharks and swordfish. The retention limits in this section are subject to the quotas and closure provisions in §§ 635.27 and 635.28. (a) Sharks. (1...

Long-term pumping test in borehole KR24 flow measurements

Energy Technology Data Exchange (ETDEWEB)

Rouhiainen, P.; Poellaenen, J. [PRG-Tec Oy, Espoo (Finland)

2005-09-15

The Difference Flow method can be used for the relatively fast determination of transmissivity and hydraulic head in fractures or fractured zones in cored boreholes. In this study, the Difference Flow method was used for hydraulic crosshole interference tests. The tests were performed in boreholes KR24 (pumped borehole) KR4, KR7, KR8, KRlO, KR14, KR22, KR22B, KR26, KR27, KR27B, KR28 and KR28B at Olkiluoto during the first and second quarters of 2004. The distance between the boreholes varies from approximately tens of meters to hundreds of meters. All the measurements were carried out in open boreholes, i.e. no packers were used. For interpretation, a normal single hole test was first performed in each borehole. Flow rates and drawdown were first measured both without pumping and with pumping the borehole under test. For practical reasons, the data set is neither complete nor similar in all tested boreholes. Connected flow to borehole KR24 was detected in all these boreholes. These flow responses were concentrated on a few zones. (orig.)

Mathematical modeling of the moderate storm on 28 February 2008

Science.gov (United States)

Eroglu, Emre

2018-04-01

The sun is an active star with plasma-filled prominences. The sudden ejection of the solar plasma creates storms in the form of bursting or spraying. A magnetospheric storm is a typical phenomenon that lasts 1-3 days and involves all magnetosphere from the earth's ionosphere to the magnetotail. The storms are known by different categorical names such as weak, moderate, strong, intense. One of these is the moderate geomagnetic storm on February 28, 2008, which occurred in the 24th solar cycle. The reason for discussing this storm is that it is the first moderate storm in the 24th solar cycle. In this study, we investigate the storm and entered the 24th solar cycle. The correlation among the parametres has been investigated via statistics. The solar wind parameters and the zonal geomagnetic indices have been analyzed separately and then the interaction with each other has been exhibited. The author has concluded the work with two new nonlinear mathematical models. These explain the storm with 79.1% and 87.5% accuracy.

Propagation of Satelite Rainfall Products uncertainties in hydrological applications : Examples in West-Africa in the framework of the Megha-Tropiques Satellite Mission

Science.gov (United States)

Casse, C.; Gosset, M.; Peugeot, C.; Boone, A.; Pedinotti, V.

2013-12-01

The use of satellite based rainfall in research or operational Hydrological application is becoming more and more frequent. This is specially true in the Tropics where ground based gauge (or radar) network are generally scarce and often degrading. Member of the GPM constellation, the new French-Indian satellite Mission Megha-Tropiques (MT) dedicated to the water and energy budget in the tropical atmosphere contributes to a better monitoring of rainfall in the inter-tropical zone. As part of this mission, research is developed on the use of MT rainfall products for hydrological research or operational application such as flood monitoring. A key issue for such applications is how to account for rainfall products biases and uncertainties, and how to propagate them in the end user models ? Another important question is how to choose the best space-time resolution for the rainfall forcing, given that both model performances and rain-product uncertainties are resolution dependent. This talk will present on going investigations and perspectives on this subject, with examples from the Megha_tropiques Ground validation sites in West Africa. The CNRM model Surfex-ISBA/TRIP has been set up to simulate the hydrological behavior of the Niger River. This modeling set up is being used to study the predictability of Niger Floods events in the city of Niamey and the performances of satellite rainfall products as forcing for such predictions. One of the interesting feature of the Niger outflow in Niamey is its double peak : a first peak attributed to 'local' rainfall falling in small to medium size basins situated in the region of Niamey, and a second peak linked to the rainfall falling in the upper par of the river, and slowly propagating through the river towards Niamey. The performances of rainfall products are found to differ between the wetter/upper part of the basin, and the local/sahelian areas. Both academic tests with artificially biased or 'perturbed' rainfield and actual

An Improved Transit Measurement for a 2.4 R ⊕ Planet Orbiting A Bright Mid-M Dwarf K2–28

Science.gov (United States)

Chen, Ge; Knutson, Heather A.; Dressing, Courtney D.; Morley, Caroline V.; Werner, Michael; Gorjian, Varoujan; Beichman, Charles; Benneke, Björn; Christiansen, Jessie L.; Ciardi, David; Crossfield, Ian; Howell, Steve B.; Krick, Jessica E.; Livingston, John; Morales, Farisa Y.; Schlieder, Joshua E.

2018-05-01

We present a new Spitzer transit observation of K2–28b, a sub-Neptune (R p = 2.45 ± 0.28 R ⊕) orbiting a relatively bright (V mag = 16.06, K mag = 10.75) metal-rich M4 dwarf (EPIC 206318379). This star is one of only seven with masses less than 0.2 {M}ȯ known to host transiting planets, and the planet appears to be a slightly smaller analogue of GJ 1214b (2.85+/- 0.20 {R}\\oplus ). Our new Spitzer observations were taken two years after the original K2 discovery data and have a significantly higher cadence, allowing us to derive improved estimates for this planet’s radius, semimajor axis, and orbital period, which greatly reduce the uncertainty in the prediction of near future transit times for the James Webb Space Telescope (JWST) observations. We also evaluate the system’s suitability for atmospheric characterization with JWST and find that it is currently the only small (K2–28b to be representative of the kind of mid-M systems that should be detectable in the TESS sample.

28 CFR 24.103 - Proceedings covered.

Science.gov (United States)

2010-07-01

... termination hearings conducted by the Office of Justice Assistance, Research, and Statistics (OJARS), the National Institute of Justice (NIJ), the Bureau of Justice Statistics (BJS) and the Office of Juvenile Justice and Delinquency Prevention (OJJDP), or the Law Enforcement Assistance Administration (LEAA) under...

Structural stabilities and electronic properties of Mg28-nAln clusters: A first-principles study

Directory of Open Access Journals (Sweden)

Bao-Juan Lu

2017-09-01

Full Text Available In this paper, we have constructed the alloy configurations of Mg28-nAln by replacing atoms at various possible positions, starting from the stable structures of Mg28 and Al28 clusters. According to the symmetry of the cluster structure, the isomers of these initial structures have been screened with the congruence check, which would reduce computational hours and improve efficiency. Using the first-principles method, the structural evolution, mixing behavior and electronic properties of Mg28-nAln clusters are investigated for all compositions. We conclude that Al atoms prefer to reside in the central positions of Mg−Al clusters and Mg atoms tend to occupy the peripheral location. The negative mixing enthalpies imply the stabilities of these Mg-Al clusters and thus possible applications in catalysis and hydrogen storage materials. Among Mg28-nAln clusters, Mg24Al4, Mg21Al7, Mg14Al14, Mg26Al2 and Mg27Al1 present relatively high thermodynamic stabilities, and the electronic properties of these stable structures are discussed with the charge distributions around the Fermi level.

31 CFR 28.310 - Recruitment.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Recruitment. 28.310 Section 28.310... Basis of Sex in Admission and Recruitment Prohibited § 28.310 Recruitment. (a) Nondiscriminatory recruitment. A recipient to which §§ 28.300 through 28.310 apply shall not discriminate on the basis of sex in...

Observation and characterization of the smallest borospherene, B28− and B28

International Nuclear Information System (INIS)

Wang, Ying-Jin; Chen, Qiang; You, Xue-Rui; Ou, Ting; Zhao, Xiao-Yun; Li, Si-Dian; Zhao, Ya-Fan; Li, Jun; Li, Wei-Li; Jian, Tian; Wang, Lai-Sheng; Zhai, Hua-Jin

2016-01-01

Free-standing boron nanocages or borospherenes have been observed recently for B 40 − and B 40 . There is evidence that a family of borospherenes may exist. However, the smallest borospherene is still not known. Here, we report experimental and computational evidence of a seashell-like borospherene cage for B 28 − and B 28 . Photoelectron spectrum of B 28 − indicated contributions from different isomers. Theoretical calculations showed that the seashell-like B 28 − borospherene is competing for the global minimum with a planar isomer and it is shown to be present in the cluster beam, contributing to the observed photoelectron spectrum. The seashell structure is found to be the global minimum for neutral B 28 and the B 28 − cage represents the smallest borospherene observed to date. It is composed of two triangular close-packed B 15 sheets, interconnected via the three corners by sharing two boron atoms. The B 28 borospherene was found to obey the 2(n + 1) 2 electron-counting rule for spherical aromaticity

[Plasma selenium and peripartum cardiomyopathy in Bamako, Mali].

Science.gov (United States)

Cénac, A; Touré, K; Diarra, M B; Sergeant, C; Jobic, Y; Sanogo, K; Dembele, M; Fayol, V; Simonoff, M

2004-01-01

Peripartum heart failure due to unexplained dilated cardiomyopathy is a common disorder as Savannak-Sahelian Africa. One of the many suspected risk factors identified is selenium deficiency. The purpose of this study was to measure plasma selenium levels in patients with peripartum heart failure due to cardiomyopathy in Bamako, Republic of Mali and compare data with healthy Sahalian women with the same obstetrical status. Plasma selenium was measured in a patient group consisting of 28 Malian women presenting peripartum heart failure and in a control group of 28 healthy breast-feeding Nigerien women of comparable age. The criteria for matching the two groups was parity (similar number of deliveries) since multiparity is a risk factor for peripartum cardiomyopathy. The Wilcoxon test (nonparametric) was used to compare the 2 groups considering up value < 0.05 as significant. Plasma selenium was significantly lower in patients from Mali than in controls from Niger (65 +/- 17 ng/ml vs. 78 +/- 17 ng/ml, p = 0.01). The results of this study showing lower plasma selenium in Bamako patients with peripartum cardiomyopathy than in a matching healthy control population confirms the previous data from the Niamey study.

2018-03-28T09:54:35Z https://www.ajol.info/index.php/all/oai oai:ojs ...

African Journals Online (AJOL)

article/86823 2018-03-28T09:54:35Z eamj:ART The prevalence of glucose intolerance among antenatal clients at Kenyatta National Hospital at, 24-36 weeks of gestation Adelaide, B Ogutu, Omondi- Mutungi, A Objectives: To determine the ...

Bacilles Gram négatifs isolées à l'examen des prélèvements ...

African Journals Online (AJOL)

Oubayyou

1 oct. 2013 ... 2 Faculté des Sciences de la Santé, Université Abdou Moumouni de Niamey, BP: ... Service de Coopération et d'Action Culturelle (SCAC, Coopération .... entre lame et lamelle, puis observée au .... Professionnel de santé.

L'évaluation comme partie intégrante du processus d'adaptation aux ...

International Development Research Centre (IDRC) Digital Library (Canada)

nbeaulieu

définitions de l'expression vulnérabilité dont certaines sont contradictoires. ... outils pour l'évaluation des impacts et l'élaboration de plans d'adaptation » à Niamey, Niger, 26 mai 2009. ..... Denton et le directeur du programme, Simon Carter.

Reductions in 28-Day Mortality Following Hospital Admission for Upper Gastrointestinal Hemorrhage

Science.gov (United States)

Crooks, Colin; Card, Tim; West, Joe

2011-01-01

Background & Aims It is unclear whether mortality from upper gastrointestinal hemorrhage is changing: any differences observed might result from changes in age or comorbidity of patient populations. We estimated trends in 28-day mortality in England following hospital admission for gastrointestinal hemorrhage. Methods We used a case-control study design to analyze data from all adults administered to a National Health Service hospital, for upper gastrointestinal hemorrhage, from 1999 to 2007 (n = 516,153). Cases were deaths within 28 days of admission (n = 74,992), and controls were survivors to 28 days. The 28-day mortality was derived from the linked national death register. A logistic regression model was used to adjust trends in nonvariceal and variceal hemorrhage mortality for age, sex, and comorbidities and to investigate potential interactions. Results During the study period, the unadjusted, overall, 28-day mortality following nonvariceal hemorrhage was reduced from 14.7% to 13.1% (unadjusted odds ratio, 0.87; 95% confidence interval: 0.84–0.90). The mortality following variceal hemorrhage was reduced from 24.6% to 20.9% (unadjusted odds ratio, 0.8; 95% confidence interval: 0.69–0.95). Adjustments for age and comorbidity partly accounted for the observed trends in mortality. Different mortality trends were identified for different age groups following nonvariceal hemorrhage. Conclusions The 28-day mortality in England following both nonvariceal and variceal upper gastrointestinal hemorrhage decreased from 1999 to 2007, and the reduction had been partly obscured by changes in patient age and comorbidities. Our findings indicate that the overall management of bleeding has improved within the first 4 weeks of admission. PMID:21447331

Elastic scattering of 12C by 28Si

International Nuclear Information System (INIS)

Cheng, C.M.; Maher, J.V.; Chiou, M.S.; Jordan, W.J.; Peng, J.C.; Oelert, W.; Gunn, G.D.; Snyder, F.D.

1979-01-01

12 C + 28 Si elastic scattering angular distributions have been measured at twenty-three bombarding energies over a range 19 MeV 0 in the bombarding energy range 30--40 MeV. No optical potential has been found to give a good account of all the data; the best potential is a surface transparent Woods-Saxon potential which has energy dependences for both real and imaginary well depths. Examination of potentials which give reasonably good fits to the 36 MeV data shows that, although these potentials agree on a real well depth at a reasonable ''strong absorption radius,'' they can have quite different Argand diagrams: even in the range of the most sensitive partial waves. A Regge analysis finds several equally good families of Regge parameters for the same choice of background potential, but larger angle data might allow this ambiguity to be lifted. A Breit-Wigner analysis gives results which are at least partially consistent with the resonance parameters reported by Ost et al. Coupled-channel calculations with a 20% reduction of real and imaginary optical model well depths give a good account of inelastic scattering to the 28 Si 2 + state while leaving the elastic scattering essentially unchanged from the predictions of the unmodified one-channel optical model. In the energy range of this study the grazing partial wave is found to be the same as the most important exit channel partial wave of the 24 Mg( 16 O, 12 C) 28 Si ground state transition

IL28B genotype is not useful for predicting treatment outcome in Asian chronic hepatitis B patients treated with pegylated interferon-α.

Science.gov (United States)

Holmes, Jacinta A; Nguyen, Tin; Ratnam, Dilip; Heerasing, Neel M; Tehan, Jane V; Bonanzinga, Sara; Dev, Anouk; Bell, Sally; Pianko, Stephen; Chen, Robert; Visvanathan, Kumar; Hammond, Rachel; Iser, David; Rusli, Ferry; Sievert, William; Desmond, Paul V; Bowden, D Scott; Thompson, Alexander J

2013-05-01

IL28B genotype predicts response to pegylated interferon (peg-IFN)-based therapy in chronic hepatitis C. However, the utility of IL28B genotyping in chronic hepatitis B (CHB) cohorts treated with peg-IFN is unclear. It was investigated whether IL28B genotype is associated with peg-IFN treatment outcomes in a predominantly Asian CHB cohort. This was a retrospective analysis of CHB patients treated with 48 weeks of peg-IFN monotherapy. IL28B genotype (rs12979860) was determined (TaqMan allelic discrimination kit). Baseline hepatitis B virus (HBV)-DNA, alanine aminotransferase, and liver histology were available. The primary end-points were HBV e antigen (HBeAg) seroconversion with HBV-DNA < 2000 IU/mL 24 weeks post-therapy (HBeAg-positive patients) and HBV-DNA < 2000 IU/mL 24 weeks after peg-IFN (HBeAg-negative patients). The association between IL28B genotype and peg-IFN outcomes was analyzed. IL28B genotype was determined for 96 patients. Eighty-eight percent were Asian, 62% were HBeAg positive, and 13% were METAVIR stage F3-4. Median follow-up time was 39.3 months. The majority of patients carried the CC IL28B genotype (84%). IL28B genotype did not differ according to HBeAg status. The primary end-points were achieved in 27% of HBeAg-positive and 61% of HBeAg-negative patients. There was no association between IL28B genotype and the primary end-point in either group. Furthermore, there was no difference in HBeAg loss alone, HBV surface antigen, alanine aminotransferase normalization, or on-treatment HBV-DNA levels according to IL28B genotype. In the context of a small possible effect size and high frequency in Asian populations, IL28B genotyping is likely to have, at best, limited clinical utility for predicting peg-IFN treatment outcome for CHB patients in the Asia-Pacific region. © 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.

Parenteral magnesium load testing with 28Mg in weanling and young adult rats

International Nuclear Information System (INIS)

Caddell, J.L.; Calhoun, N.R.; Howard, M.P.; Patterson, K.Y.; Smith, J.C. Jr.

1981-01-01

A sound diagnostic test for Mg deficiency is needed. This is a report of the parenteral Mg load test conducted in weanling and young adult rats fed a purified basal diet containing 3 mg magnesium/100 g with 150 mg of added magnesium/100 g (control) or 0 added magnesium (deficient). Weanlings were studied at about 1 week of dietary treatment and young adults at 2 weeks. The protocol included: a) a 6-hour preload urinary collection; b) an intraperitoneal load of 15 mg of magnesium/kg (weanlings) or 12 mg/kg (young adults) with 2 microCi 28Mg given simultaneously with each load; c) a 6-hour postload urinary collection; d) chemical analysis of selected tissues and urine for Mg; and e) 28Mg counting 6 and 24 hours postload. Controls all excreted large amounts of Mg pre- and postload, retaining less than 26% of nonradioactive loads. They had high urinary 28Mg counts. In Mg-deficient animals, the concentration of Mg in bone more than halved. These animals avidly conserved Mg and retained over 85% of nonradioactive Mg loads. Their 28Mg activity in vital organs was 3--6 times greater than in controls. We concluded that the parenteral Mg load test reliably identifies severe Mg deficiency

228-IJBCS-Article-Dr B ALHOU

African Journals Online (AJOL)

Dr Gatsing

Le fleuve Niger est le récepteur principal des rejets d'eaux usées de la ville de Niamey, ..... T=température; CE=conductivité électrique; DCO=demande chimique en ..... pluvial dans le bassin du Srou (Maroc central). Sécheresse, 16: 41-52.

Particle decays in /sup 28/Si: The destruction of /sup 27/Al in red giants and novae

Energy Technology Data Exchange (ETDEWEB)

Champagne, A E; Cella, C H; Kouzes, R T; Lowry, M M; Magnus, P V; Smith, M S; Mao, Z Q

1988-10-10

The /sup 27/Al(/sup 3/He,d)/sup 28/Si reaction has been used to populate states near the /sup 27/Al+p threshold and the ensuing proton and alpha decay has been measured. No evidence for new /sup 27/Al(p,..cap alpha..)/sup 24/Mg resonance strength was observed and consequently revised limits have been placed on the thermonuclear reaction rate. As a result, the /sup 27/Al(p,..cap alpha..)/sup 24/Mg reaction is found to be astrophysically unimportant at red-giant and nova temperatures.

31 CFR 28.200 - Application.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Application. 28.200 Section 28.200 Money and Finance: Treasury Office of the Secretary of the Treasury NONDISCRIMINATION ON THE BASIS OF... Application. Except as provided in §§ 28.205 through 28.235(a), these Title IX regulations apply to every...

White spot syndrome virus envelope protein VP28 is involved in the systemic infection of shrimp

NARCIS (Netherlands)

Hulten, van M.C.W.; Witteveldt, J.; Snippe, M.; Vlak, J.M.

2001-01-01

White spot syndrome virus (WSSV) is a large DNA virus infecting shrimp and other crustaceans. The virus particles contain at least five major virion proteins, of which three (VP26, VP24, and VP15) are present in the rod-shaped nucleocapsid and two (VP28 and VP19) reside in the envelope. The mode of

Caractéristiques physico-chimiques et pollution de l'eau du delta de ...

African Journals Online (AJOL)

SARAH

31 janv. 2016 ... (2001) a été utilisé pour apprécier le niveau de pollution des eaux. Les résultats de l'ACD ont ... L'agriculture intensive, la pêche, l'extraction de ..... qualité physicochimique et biologique des eaux du fleuve Niger à Niamey.

Browse Title Index

African Journals Online (AJOL)

zemidjan" de la ville de Porto-Novo (Benin). Abstract. B Akplogan, MM Lawani, AD Fanou. Vol 15, No 2 (2013): Series A,B,D,E, La surveillance des abords vasculaires chez les hémodialysés chroniques à l'Hôpital National de Lamordé Niamey ...

Vertical Electrical Sounding to delineate the potential Aquifer zones ...

Indian Academy of Sciences (India)

48

CSIR-National Geophysical Research Institute, Groundwater Building, Uppal Road, ... techniques for groundwater prospecting was used in the Capital City, Niamey of Niger. ... Analysis of the result showed a good correlation between the ..... Fitterman D V, Meekes J A C, and Ritsema I L, 1988, Equivalence behavior of three ...

24 CFR 84.24 - Program income.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Program income. 84.24 Section 84.24... income. (a) HUD shall apply the standards set forth in this section in requiring recipient organizations to account for program income related to projects financed in whole or in part with Federal funds. (b...

The Relationship Between Function and Disease Activity as Measured by the HAQ and DAS28 Varies Over Time and by Rheumatoid Factor Status in Early Inflammatory Arthritis (EIA). Results from the CATCH Cohort.

Science.gov (United States)

Boyd, Tristan A; Bonner, A; Thorne, C; Boire, G; Hitchon, C; Haraoui, B P; Keystone, E C; Bykerk, V P; Pope, J E

2013-01-01

To investigate the relationship between function and disease activity in early inflammatory arthritis (EIA). Canadian Early Arthritis Cohort (CATCH) (n=1143) is a multi-site EIA cohort. Correlations between the Health Assessment Questionnaire Disability Index (HAQ) and DAS28 were done at every 3 months for the first year and then at 18 and 24 months. We also investigated the relationship between HAQ and DAS28 by age (<65 versus ≥65) and RF (positive vs negative). Mean HAQ and DAS28 scores were highest at the initial visit with HAQ decreasing over 24 months from a baseline of 0.94 to 0.40 and DAS28 scores decreasing from 4.54 to 2.29. All correlations between HAQ and DAS28 were significant at all time points (p<0.01). The correlations between HAQ and DAS28 were variable over time. The strongest correlation between HAQ and DAS28 occurred at initial visit (most DMARD naive) (n=1,143) and 18 months (r=0.57, n=321) and 24 months (r=0.59, n=214). The baseline correlation between HAQ and DAS28 was significantly different than correlations obtained at 3, 6, and 12 months (p=0.02, 0.01, and 0.01, respectively). Age did not change the association between HAQ and DAS28 {<65 years old (r=0.50, n=868) versus ≥65 (r=0.48, n=254), p=0.49}. The correlation between HAQ and DAS28 was stronger with RF+ patients (r=0.63, n=636) vs RF negative (r=0.47, n=477), p=0.0043. Over 2 years in EIA, HAQ and DAS both improved; correlations at time points were different over 2 years and RF status affected the correlations.

Shape memory characteristics of Ti-22Nb-(2-8)Zr(at.%) biomedical alloys

International Nuclear Information System (INIS)

Kim, J.I.; Kim, H.Y.; Inamura, T.; Hosoda, H.; Miyazaki, S.

2005-01-01

Shape memory characteristics of Ti-22Nb-(2-8)Zr(at.%) biomedical alloys were investigated by using tensile tests and X-ray diffraction (XRD) measurement. The alloy ingots were fabricated by an arc melting method. The ingots were cold-rolled by a reduction up to 95% in thickness at room temperature. All the alloys were solution-treated at 1173 K for 1.8 ks. The alloys subjected to the solution treatment exhibited large elongations ranging between 28 and 40%. The martensitic transformation temperature decreased by 38 K with 1 at.% increase of Zr content. The maximum recovered strain of 4.3% was obtained in the Ti-22Nb-4Zr(at.%) alloy. Ti-22Nb-(2-4)Zr(at.%) and Ti-22Nb-6Zr(at.%) alloys exhibited stable shape memory effect and superelastic behavior at room temperature, respectively

46 CFR 28.120 - Survival craft.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Survival craft. 28.120 Section 28.120 Shipping COAST... VESSELS Requirements for All Vessels § 28.120 Survival craft. (a) Except as provided in paragraphs (b) through (h) of this section and 28.305, each vessel must carry the survival craft specified in Table 28...

Social Representations and Uses of Technologies of African High-School Students

Science.gov (United States)

Karsenti, Thierry; Kouawo, Achille

2015-01-01

This article examines social representations of information and communications technologies (ICT) in high school students in Niamey, Niger, and explores whether these representations are determined by training in and regular use of ICT. A sample of 50 students attending two "lycées" was studied. Only one "lycée" offered…

Présentation d’Eurocall 2003 "New Literacies in Language Learning & Teaching"

Directory of Open Access Journals (Sweden)

François Mangenot

2003-12-01

Full Text Available Eurocall est une association européenne de chercheurs et de praticiens du domaine de l’apprentissage des langues assisté par ordinateur (Eurocall ; cette association tient chaque année, en août-septembre, un colloque qui regroupe plusieurs centaines de participants. Cet article propose un compte-rendu du colloque qui s'est tenu à l'université de Limerick (Irlande du 3 au 6 septembre 2003. On aborde tout d’abord le thème du colloque, on propose ensuite une synthèse des trois conférences plénières et des 166 ateliers, on approfondit enfin l’un des sous-thèmes, celui de la communication pédagogique et interculturelle à travers Internet.

Comparison of INTAKE24 (an Online 24-h Dietary Recall Tool) with Interviewer-Led 24-h Recall in 11-24 Year-Old.

Science.gov (United States)

Bradley, Jennifer; Simpson, Emma; Poliakov, Ivan; Matthews, John N S; Olivier, Patrick; Adamson, Ashley J; Foster, Emma

2016-06-09

Online dietary assessment tools offer a convenient, low cost alternative to traditional dietary assessment methods such as weighed records and face-to-face interviewer-led 24-h recalls. INTAKE24 is an online multiple pass 24-h recall tool developed for use with 11-24 year-old. The aim of the study was to undertake a comparison of INTAKE24 (the test method) with interviewer-led multiple pass 24-h recalls (the comparison method) in 180 people aged 11-24 years. Each participant completed both an INTAKE24 24-h recall and an interviewer-led 24-h recall on the same day on four occasions over a one-month period. The daily energy and nutrient intakes reported in INTAKE24 were compared to those reported in the interviewer-led recall. Mean intakes reported using INTAKE24 were similar to the intakes reported in the interviewer-led recall for energy and macronutrients. INTAKE24 was found to underestimate energy intake by 1% on average compared to the interviewer-led recall with the limits of agreement ranging from minus 49% to plus 93%. Mean intakes of all macronutrients and micronutrients (except non-milk extrinsic sugars) were within 4% of the interviewer-led recall. Dietary assessment that utilises technology may offer a viable alternative and be more engaging than paper based methods, particularly for children and young adults.

Association analyses suggest GPR24 as a shared susceptibility gene for bipolar affective disorder and schizophrenia

DEFF Research Database (Denmark)

Severinsen, J E; Als, T D; Binderup, H

2006-01-01

(-5) and 0.0006 in the combined group of cases from the Faeroe Islands and Scotland, respectively. The G protein-coupled receptor 24 encoded by GPR24 binds melanin-concentrating hormone (MCH) and has been implicated with feeding behavior, energy metabolism, and regulation of stress and mood. To our knowledge...... comprising 28 distantly related cases (17 BPD, 11 SZ subjects) and 44 controls, and a Scottish sample including 162 patients with BPD, 103 with SZ, and 200 controls. In both samples significant associations were observed in both disorders with predominantly GPR24 SNPs and haplotypes. In the Faeroese sample...

7 CFR 28.909 - Costs.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Costs. 28.909 Section 28.909 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing..., TESTING, AND STANDARDS Cotton Classification and Market News Service for Producers Sampling § 28.909 Costs...

32 CFR 651.28 - Introduction.

Science.gov (United States)

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true Introduction. 651.28 Section 651.28 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) ENVIRONMENTAL QUALITY ENVIRONMENTAL ANALYSIS OF ARMY ACTIONS (AR 200-2) Categorical Exclusions § 651.28 Introduction. Categorical...

32 CFR 147.28 - Introduction.

Science.gov (United States)

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Introduction. 147.28 Section 147.28 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN... Temporary Access § 147.28 Introduction. The following minimum investigative standards, implementing section...

49 CFR 28.160 - Communications.

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Communications. 28.160 Section 28.160 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION § 28.160 Communications...

Is the use of IL28B genotype justified in the era of interferon-free treatments for hepatitis C?

Science.gov (United States)

Kanda, Tatsuo; Nakamoto, Shingo; Yokosuka, Osamu

2015-01-01

In 2009, several groups reported that interleukin-28B (IL28B) genotypes are associated with the response to peginterferon plus ribavirin therapy for chronic hepatitis C virus (HCV) infection in a genome-wide association study, although the mechanism of this association is not yet well understood. However, in recent years, tremendous progress has been made in the treatment of HCV infection. In Japan, some patients infected with HCV have the IL28B major genotype, which may indicate a favorable response to interferon-including regimens; however, certain patients within this group are also interferon-intolerant or ineligible. In Japan, interferon-free 24-wk regimens of asunaprevir and daclatasvir are now available for HCV genotype 1b-infected patients who are interferon-intolerant or ineligible or previous treatment null-responders. The treatment response to interferon-free regimens appears better, regardless of IL28B genotype. Maybe other interferon-free regimens will widely be available soon. In conclusion, although some HCV-infected individuals have IL28B favorable alleles, importance of IL28B will be reduced with availability of oral interferon free regimen. PMID:26279979

Degradation characteristics of 2,4-dichlorophenoxyacetic acid in electro-biological system

Energy Technology Data Exchange (ETDEWEB)

Zhang, JingLi, E-mail: jinglizhangczp@126.com [Tianjin Key Laboratory of Aquatic Science and Technology, Tianjin Institute of Urban Construction, Tianjin 300384 (China); Cao, ZhanPing; Zhang, HongWei [School of Environmental and Chemical Engineering, Tianjin Polytechnic University, Tianjin 300387 (China); Zhao, LianMei [Tianjin Key Laboratory of Aquatic Science and Technology, Tianjin Institute of Urban Construction, Tianjin 300384 (China); Sun, XuDong; Mei, Feng [School of Environmental and Chemical Engineering, Tianjin Polytechnic University, Tianjin 300387 (China)

2013-11-15

Highlights: • The 2,4-D reductive degradation was studied in an electro-biological system. • The electric auxiliary accelerates 2,4-D microbial degradation. • A electron transfer is achieved between the electrode, bacteria and the pollutants. • The paper provides a promising way for the degradation of persistent organics. -- Abstract: The reductive degradation of 2,4-dichlorophenoxyacetic acid (2,4-D) was studied in an electro-biological system, a biological system and an electric catalytic system, respectively. Electrochemical characteristics were monitored by cyclic voltammetry and the intermediate products of 2,4-D degradation were determined by high speed liquid chromatography (HPLC). The results showed that all 2,4-D degradations in the three systems conformed to the kinetics characteristics of one-order reaction, and the degradation kinetics constants were 28.74 × 10{sup −2} h{sup −1}, 19.73 × 10{sup −2} h{sup −1} and 3.54 × 10{sup −2} h{sup −1}, respectively. The kinetics constant in the electro-biological system was higher than the sum in the other two systems by 19%. The electrochemical assistance provided the electrons and accelerated the electron transfer rate in the microbial degradation of 2,4-D. The degradation resulted from the microbial reduction strengthened by the electrochemical assistance. The electron transfer existed between the electrode, cytochrome, NAD and the pollutants. A long-range electron transfer process could be achieved on the multi-phase interfaces between the electrode, bacteria and the pollutants.

19 CFR 210.28 - Depositions.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Depositions. 210.28 Section 210.28 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Discovery and Compulsory Process § 210.28 Depositions. (a) When depositions may be...

49 CFR 28.102 - Application.

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Application. 28.102 Section 28.102 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION § 28.102 Application. This part...

31 CFR 28.540 - Advertising.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Advertising. 28.540 Section 28.540... Basis of Sex in Employment in Education Programs or Activities Prohibited § 28.540 Advertising. A recipient shall not in any advertising related to employment indicate preference, limitation, specification...

30 CFR 281.28 - Royalty.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Royalty. 281.28 Section 281.28 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE LEASING OF MINERALS OTHER THAN OIL, GAS, AND SULPHUR IN THE OUTER CONTINENTAL SHELF Financial Considerations § 281.28 Royalty. (a...

49 CFR 28.111 - Notice.

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Notice. 28.111 Section 28.111 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION § 28.111 Notice. The Department shall...

49 CFR 28.140 - Employment.

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Employment. 28.140 Section 28.140 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION § 28.140 Employment. (a) No qualified...

49 CFR 28.101 - Purpose.

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Purpose. 28.101 Section 28.101 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION § 28.101 Purpose. The purpose of this...

Efficacy and safety at 24 weeks of daily clinical use of tofacitinib in patients with rheumatoid arthritis.

Science.gov (United States)

Iwamoto, Naoki; Tsuji, Sosuke; Takatani, Ayuko; Shimizu, Toshimasa; Fukui, Shoichi; Umeda, Masataka; Nishino, Ayako; Horai, Yoshiro; Koga, Tomohiro; Kawashiri, Shin-Ya; Aramaki, Toshiyuki; Ichinose, Kunihiro; Hirai, Yasuko; Tamai, Mami; Nakamura, Hideki; Terada, Kaoru; Origuchi, Tomoki; Eguchi, Katsumi; Ueki, Yukitaka; Kawakami, Atsushi

2017-01-01

We evaluated the efficacy and safety of tofacitinib in patients with rheumatoid arthritis (RA) in a real-world setting. Seventy consecutive patients, for whom tofacitinib was initiated between November 2013 and May 2016, were enrolled. All patients fulfilled the 2010 ACR/EULAR classification criteria for RA. All patients received 5 mg of tofacitinib twice daily and were followed for 24 weeks. Clinical disease activity indicated by disease activity score (DAS)28-ESR, the simplified disease activity index, and the clinical disease activity index as well as adverse events (AEs) were evaluated. Statistical analysis was performed to determine which baseline variables influenced the efficacy of tofacitinib at 24 weeks. Fifty-eight patients (82.9%) continued tofacitinib at 24 weeks. Clinical disease activity rapidly and significantly decreased, and this efficacy continued throughout the 24 weeks: i.e., DAS28-ESR decreased from 5.04 ± 1.33 at baseline to 3.83 ± 1.11 at 4 weeks and 3.53 ± 1.17 at 24 weeks (Ptofacitinib treatment. The efficacy of tofacitinib was not changed in patients without concomitant use of methotrexate (MTX) or patients whose treatment with tocilizumab (TCZ) failed. Multivariable logistic analysis showed that the number of biologic DMARDs (bDMARDs) previously used was independently associated with achievement of DAS-low disease activity. Our present study suggests that tofacitinib is effective in real-world settings even without concomitant MTX use or after switching from TCZ. Our results also suggest that its efficacy diminishes if started after use of multiple bDMARDs.

29 CFR 1905.28 - Exceptions.

Science.gov (United States)

2010-07-01

... OCCUPATIONAL SAFETY AND HEALTH ACT OF 1970 Hearings § 1905.28 Exceptions. Within 20 days after service of a... 29 Labor 5 2010-07-01 2010-07-01 false Exceptions. 1905.28 Section 1905.28 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR RULES OF...

7 CFR 1216.28 - State.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false State. 1216.28 Section 1216.28 Agriculture... INFORMATION ORDER Peanut Promotion, Research, and Information Order Definitions § 1216.28 State. State means any of the 50 states, the District of Columbia, the Commonwealth of Puerto Rico, or any territory or...

31 CFR 28.405 - Housing.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Housing. 28.405 Section 28.405 Money... in Education Programs or Activities Prohibited § 28.405 Housing. (a) Generally. A recipient shall not... offer different services or benefits related to housing, except as provided in this section (including...

27 CFR 28.213 - [Reserved

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2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false [Reserved] 28.213 Section 28.213 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS EXPORTATION OF ALCOHOL Exportation of Wine With Benefit of Drawback § 28.213...

Publications | Page 614 | IDRC - International Development ...

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Results 6131 - 6140 of 6371 ... Waterpipe tobacco smoking : building the evidence base; part 1: the smoke chemistry (open access) · Farming and livestock production in the Sahel : merging the two solutions (open access). The women of Toukounous, a small town 20 km from Niamey, are participating in a new departure from ...

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African Journals Online (AJOL)

Vol 6, No 1 (2010), Étude des performances thermiques d'un réfrigérateur local ... Vol 7, No 2 (2011), Évaluation des rejets d'eaux usées de la ville de Niamey ... Industriel : Cas de la plaine de la Meboudja, Nord-Est Algérien, Abstract PDF.

7 CFR 283.28 - Discovery.

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2010-01-01

... 7 Agriculture 4 2010-01-01 2010-01-01 false Discovery. 283.28 Section 283.28 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... Appeals of QC Claims of Less Than $50,000 § 283.28 Discovery. Upon motion and as ordered by the ALJ...

31 CFR 28.510 - Recruitment.

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2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Recruitment. 28.510 Section 28.510... Basis of Sex in Employment in Education Programs or Activities Prohibited § 28.510 Recruitment. (a) Nondiscriminatory recruitment and hiring. A recipient shall not discriminate on the basis of sex in the recruitment...

32 CFR 28.105 - Definitions.

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2010-07-01

... services in the private sector. (o) Recipient includes all contractors, subcontractors at any tier, and... 32 National Defense 1 2010-07-01 2010-07-01 false Definitions. 28.105 Section 28.105 National... RESTRICTIONS ON LOBBYING General § 28.105 Definitions. For purposes of this part: (a) Agency, as defined in 5 U...

Interleukin 28B gene variation at rs12979860 determines early viral kinetics during treatment in patients carrying genotypes 2 or 3 of hepatitis C virus

DEFF Research Database (Denmark)

Lindh, Magnus; Lagging, Martin; Färkkilä, Martti

2011-01-01

Single-nucleotide polymorphisms upstream of the interleukin 28B (interferon λ3) gene (IL28B) strongly influence treatment efficacy in patients carrying hepatitis C virus (HCV) of genotype 1. In patients receiving 12 or 24 weeks of interferon-ribavirin therapy for infection with genotype 2 or 3 (n...... = 341), we found that rs12979860 strikingly determined the first phase of viral elimination (P

Comparison of INTAKE24 (an Online 24-h Dietary Recall Tool with Interviewer-Led 24-h Recall in 11–24 Year-Old

Directory of Open Access Journals (Sweden)

Jennifer Bradley

2016-06-01

Full Text Available Online dietary assessment tools offer a convenient, low cost alternative to traditional dietary assessment methods such as weighed records and face-to-face interviewer-led 24-h recalls. INTAKE24 is an online multiple pass 24-h recall tool developed for use with 11–24 year-old. The aim of the study was to undertake a comparison of INTAKE24 (the test method with interviewer-led multiple pass 24-h recalls (the comparison method in 180 people aged 11–24 years. Each participant completed both an INTAKE24 24-h recall and an interviewer-led 24-h recall on the same day on four occasions over a one-month period. The daily energy and nutrient intakes reported in INTAKE24 were compared to those reported in the interviewer-led recall. Mean intakes reported using INTAKE24 were similar to the intakes reported in the interviewer-led recall for energy and macronutrients. INTAKE24 was found to underestimate energy intake by 1% on average compared to the interviewer-led recall with the limits of agreement ranging from minus 49% to plus 93%. Mean intakes of all macronutrients and micronutrients (except non-milk extrinsic sugars were within 4% of the interviewer-led recall. Dietary assessment that utilises technology may offer a viable alternative and be more engaging than paper based methods, particularly for children and young adults.

6 CFR 13.28 - Motions.

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2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Motions. 13.28 Section 13.28 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.28 Motions. (a) Any application to the ALJ for an order or ruling will be by motion. Motions will state the relief...

46 CFR 28.10 - Authority.

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2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Authority. 28.10 Section 28.10 Shipping COAST GUARD... General Provisions § 28.10 Authority. The regulations in this part are prescribed by the Commandant of the Coast Guard, pursuant to a delegation of authority by the Secretary of Homeland Security set forth in...

27 CFR 28.110 - Losses.

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2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Losses. 28.110 Section 28... Manufacturing Bonded Warehouse Losses § 28.110 Losses. Where there has been a loss of distilled spirits while in... of subpart O of this part, with respect to losses of spirits after withdrawal without payment of tax...

27 CFR 28.149 - Losses.

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2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Losses. 28.149 Section 28... Exportation, Use as Supplies on Vessels and Aircraft, or Transfer to a Foreign-Trade Zone § 28.149 Losses. When there has been a loss of beer or beer concentrate while in transit from the brewery to a port for...

27 CFR 28.127 - Losses.

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2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Losses. 28.127 Section 28... to a Manufacturing Bonded Warehouse § 28.127 Losses. Where there has been a loss of wine while in..., with respect to losses of wine after withdrawal without payment of tax and to claims for remission of...

27 CFR 28.156 - Losses.

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2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Losses. 28.156 Section 28... Exportation or Transfer to a Foreign-Trade Zone § 28.156 Losses. Where there has been a loss of specially... or a foreign-trade zone, the exporter shall file claim for allowance of the loss in accordance with...

Toxicological responses of red-backed salamanders (Plethodon cinereus) to subchronic soil exposures of 2,4-dinitrotoluene

International Nuclear Information System (INIS)

Johnson, Mark S.; Suski, Jamie; Bazar, Matthew A.

2007-01-01

Dinitrotoluenes are used as propellants and in explosives by the military and as such have been found at relatively high concentrations in the soil. To determine whether concentrations of 2,4-dinitrotoluene (2,4-DNT) in soil are toxic to amphibians, 100 red-backed salamanders (Plethodon cinereus) were exposed to either 1500, 800, 200, 75 or 0 mg 2,4-DNT/kg soil for 28 days and evaluated for indicators of toxicity. Concentrations of 2,4-DNT were less than targets and varied with time. Most salamanders exposed to concentrations exceeding 1050 mg/kg died or were moribund within the first week. Salamanders exposed to soil concentrations exceeding 345 mg/kg lost >6% of their body mass though no mortality occurred. Overt effects included a reduction in feed consumption and an increase in bucco-pharyngeal oscillations in salamanders. These results suggest that only high soil concentrations of 2,4-DNT have the potential to cause overtly toxic effects in terrestrial salamanders. - Exposures of 2,4-dinitrotoluene in soil exceeding 345 mg/kg causes toxicity to P. cinereus

Differences in gene expression profiles in the liver between carcinogenic and non-carcinogenic isomers of compounds given to rats in a 28-day repeat-dose toxicity study

International Nuclear Information System (INIS)

Nakayama, Koji; Kawano, Yukiko; Kawakami, Yuuki; Moriwaki, Norichika; Sekijima, Masaru; Otsuka, Masanori; Yakabe, Yoshikuni; Miyaura, Hideki; Saito, Koichi; Sumida, Kayo; Shirai, Tomoyuki

2006-01-01

Some compounds have structural isomers of which one is apparently carcinogenic, and the other not. Because of the similarity of their chemical structures, comparisons of their effects can allow gene expression elicited in response to the basic skeletons of the isomers to be disregarded. We compared the gene expression profiles of male Fischer 344 rats administered by daily oral gavage up to 28 days using an in-house oligo microarray. 2-Acetylaminofluorene (2-AAF), 2,4-diaminotoluene (2,4-DAT), 2-nitropropane (2-NP), and 2-nitro-p-phenylenediamine (2-NpP) are hepatocarcinogenic. However, their isomers, 4-acetylaminofluorene (4-AAF), 2,6-diaminotoluene (2,6-DAT), 1-nitropropane (1-NP), and 4-nitro-o-phenylenediamine (4-NoP), are non-hepatocarcinogenic. Because of the limited carcinogenicity of 2-NpP, we attempted to perform two-parametric comparison analyses with (1) a set of 4 isomers: 2-AAF, 2,4-DAT, 2-NP, and 2-NpP as 'carcinogenic', and 4-AAF, 2,6-DAT, 1-NP, and 4-NoP as 'non-carcinogenic'; and (2) a set of 3 isomers: 2-AAF, 2,4-DAT, and 2-NP, as 'carcinogenic', and 4-AAF, 2,6-DAT, and 1-NP as 'non-carcinogenic'. After ratio filtering and Welch's approximate t-test analysis, 54 and 28 genes were selected from comparisons between the sets of 3 and 4 isomers, respectively, for day 28 data. Using hierarchical clustering analysis with the 54 or 28 genes, 2-AAF, 2,4-DAT, and 2-NP clustered into a 'carcinogenic' branch. 2-NpP was in the same cluster as 4-NoP and 4-AAF. This clustering corresponded to the previous finding that 2-NpP is not carcinogenic in male Fischer 344 rats, which indicates that comparing the differences in gene expression elicited by different isomers is an effective method of developing a prediction system for carcinogenicity

Determination of stable and radioactive isotopes in rain water for the equatorial and Sahel zones

International Nuclear Information System (INIS)

Baudet, J.; Lesne, H.

1975-01-01

The extension of desert zones to detriment of Sahel zones lead to look for the circuit followed by water vapor between its principal source, i.e. the Guinea Gulf, and the place where it is changed in precipitation. Samples of rainwater have been collected in Abidjan, Ouagadougou, and Niamey when the Intertropical Front was beginning its moving down towards the South, i.e. at the end of the rainy season for the Sahel zone, and at the beginning of the small rainy season for the equatorial zone. The analysis of these tritium, deuterium and oxygen-18 contents show that: the rains collected in Abidjan comes mainly from Ocean; the rains collected in Ouagadougou and Niamey have followed a long journey above the continent, as shown by the tritium content. The water evaporated in the Guinea Gulf is condensed in the convergence zone above Cameroon, and mixed with re-evaporated continental water. The content of one of the Ouagadougou sample shows that the rain issued from a local cumulonimbus has drawn a part of its water from the stratosphere [fr

Molecular resonances in 28SI + 28Si - Wobbling motions observed by angular correlation measurements

International Nuclear Information System (INIS)

Uegaki, E.; Abe, Y.

2014-01-01

High-spin resonances observed in 28 Si+ 28 Si collisions are studied with a dinuclear molecular model. At high spins, a stable dinuclear configuration of the oblate-oblate system ( 28 Si+ 28 Si) is found to be an equator-equator (E-E) touching one. Normal modes have been investigated around the equilibrium, which are expected to be an origin of a large number of the resonances observed. Analyses of physical quantities are made and compared with the recent experimental data measured at Strasbourg. Since the E-E configuration is slightly triaxial, rotations of the total system induce mixing of K quantum numbers, called wobbling motion, which clearly explains the particle-γ angular correlations observed as well as the misalignments observed in the angular distributions, in a simple and natural way. Furthermore, predictions are given for the angular correlations of the wobbling excited states. The importance of the angular correlation measurements is stressed, which provide identification of the dinuclear configurations by spin orientations of the constituent nuclei 28 Si. (authors)

123 I production using CV-28 cyclotron from IPEN-CNEN/SP

International Nuclear Information System (INIS)

Mestnik, S.A.C.; Mengatti, J.; Nieto, W.; Yanagawa, S.I.; Sumiya, L.C.A.; Silva, C.P.G.; Osso Junior, J.A.

1992-01-01

The main conditions for iodine 123 production by 124 Te (p,2 n) 123 I reaction were presented, using the cyclotron CV-28 at IPEN-CNEN/SP, with protons of E max = 24 MeV. Two types of targets (Te O 2 and Te O 2 + 2% Al 2 O 3 ) and the influence of Al 2 O 3 in iodine release were studied. After the selection, the 124 Te O 2 (96,2%) target, was melted in platinum support and irradiated with proton current until 12 mu A. The separation of 123 I was made by dry distillation, using induction furnace and O 2 atmosphere. (C.G.C.)

Disruption of spindle checkpoint function in rats following 28 days of repeated administration of renal carcinogens.

Science.gov (United States)

Kimura, Masayuki; Mizukami, Sayaka; Watanabe, Yousuke; Hasegawa-Baba, Yasuko; Onda, Nobuhiko; Yoshida, Toshinori; Shibutani, Makoto

2016-02-01

We previously reported that 28-day exposure to hepatocarcinogens that facilitate cell proliferation specifically alters the expression of G1/S checkpoint-related genes and proteins, induces aberrant early expression of ubiquitin D (UBD) at the G2 phase, and increases apoptosis in the rat liver, indicating G1/S and spindle checkpoint dysfunction. The present study aimed to determine the time of onset of carcinogen-specific cell-cycle disruption after repeated administration of renal carcinogens for up to 28 days. Rats were orally administered the renal carcinogens nitrofurantoin (NFT), 1-amino-2,4-dibromoantraquinone (ADAQ), and 1,2,3-trichloropropane (TCP) or the non-carcinogenic renal toxicants 1-chloro-2-propanol, triamterene, and carboxin for 3, 7 or 28 days. Both immunohistochemical single-molecule analysis and real-time RT-PCR analysis revealed that carcinogen-specific expression changes were not observed after 28 days of administration. However, the renal carcinogens ADAQ and TCP specifically reduced the number of cells expressing phosphorylated-histone H3 at Ser10 in both UBD(+) cells and proliferating cells, suggestive of insufficient UBD expression at the M phase and early transition of proliferating cells from the M phase, without increasing apoptosis, after 28 days of administration. In contrast, NFT, which has marginal carcinogenic potential, did not induce such cellular responses. These results suggest that it may take 28 days to induce spindle checkpoint dysfunction by renal carcinogens; however, induction of apoptosis may not be essential. Thus, induction of spindle checkpoint dysfunction may be dependent on carcinogenic potential of carcinogen examined, and marginal carcinogens may not exert sufficient responses even after 28 days of administration.

28 CFR 70.28 - Period of availability of funds.

Science.gov (United States)

2010-07-01

... REQUIREMENTS FOR GRANTS AND AGREEMENTS (INCLUDING SUBAWARDS) WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Financial and Program Management § 70.28...

Efficacy and safety at 24 weeks of daily clinical use of tofacitinib in patients with rheumatoid arthritis.

Directory of Open Access Journals (Sweden)

Naoki Iwamoto

Full Text Available We evaluated the efficacy and safety of tofacitinib in patients with rheumatoid arthritis (RA in a real-world setting.Seventy consecutive patients, for whom tofacitinib was initiated between November 2013 and May 2016, were enrolled. All patients fulfilled the 2010 ACR/EULAR classification criteria for RA. All patients received 5 mg of tofacitinib twice daily and were followed for 24 weeks. Clinical disease activity indicated by disease activity score (DAS28-ESR, the simplified disease activity index, and the clinical disease activity index as well as adverse events (AEs were evaluated. Statistical analysis was performed to determine which baseline variables influenced the efficacy of tofacitinib at 24 weeks.Fifty-eight patients (82.9% continued tofacitinib at 24 weeks. Clinical disease activity rapidly and significantly decreased, and this efficacy continued throughout the 24 weeks: i.e., DAS28-ESR decreased from 5.04 ± 1.33 at baseline to 3.83 ± 1.11 at 4 weeks and 3.53 ± 1.17 at 24 weeks (P<0.0001, vs. baseline. 15 AEs including 5 herpes zoster infection occurred during tofacitinib treatment. The efficacy of tofacitinib was not changed in patients without concomitant use of methotrexate (MTX or patients whose treatment with tocilizumab (TCZ failed. Multivariable logistic analysis showed that the number of biologic DMARDs (bDMARDs previously used was independently associated with achievement of DAS-low disease activity.Our present study suggests that tofacitinib is effective in real-world settings even without concomitant MTX use or after switching from TCZ. Our results also suggest that its efficacy diminishes if started after use of multiple bDMARDs.

Observation and characterization of the smallest borospherene, B{sub 28}{sup −} and B{sub 28}

Energy Technology Data Exchange (ETDEWEB)

Wang, Ying-Jin; Chen, Qiang; You, Xue-Rui; Ou, Ting; Zhao, Xiao-Yun; Li, Si-Dian, E-mail: hj.zhai@sxu.edu.cn, E-mail: lisidian@sxu.edu.cn, E-mail: junli@tsinghua.edu.cn, E-mail: lai-sheng-wang@brown.edu [Nanocluster Laboratory, Institute of Molecular Science, Shanxi University, Taiyuan 030006 (China); Zhao, Ya-Fan; Li, Jun, E-mail: hj.zhai@sxu.edu.cn, E-mail: lisidian@sxu.edu.cn, E-mail: junli@tsinghua.edu.cn, E-mail: lai-sheng-wang@brown.edu [Department of Chemistry and Key Laboratory of Organic Optoelectronics and Molecular Engineering of Ministry of Education, Tsinghua University, Beijing 100084 (China); Li, Wei-Li; Jian, Tian; Wang, Lai-Sheng, E-mail: hj.zhai@sxu.edu.cn, E-mail: lisidian@sxu.edu.cn, E-mail: junli@tsinghua.edu.cn, E-mail: lai-sheng-wang@brown.edu [Department of Chemistry, Brown University, Providence, Rhode Island 02912 (United States); Zhai, Hua-Jin, E-mail: hj.zhai@sxu.edu.cn, E-mail: lisidian@sxu.edu.cn, E-mail: junli@tsinghua.edu.cn, E-mail: lai-sheng-wang@brown.edu [Nanocluster Laboratory, Institute of Molecular Science, Shanxi University, Taiyuan 030006 (China); State Key Laboratory of Quantum Optics and Quantum Optics Devices, Shanxi University, Taiyuan 030006 (China)

2016-02-14

Free-standing boron nanocages or borospherenes have been observed recently for B{sub 40}{sup −} and B{sub 40}. There is evidence that a family of borospherenes may exist. However, the smallest borospherene is still not known. Here, we report experimental and computational evidence of a seashell-like borospherene cage for B{sub 28}{sup −} and B{sub 28}. Photoelectron spectrum of B{sub 28}{sup −} indicated contributions from different isomers. Theoretical calculations showed that the seashell-like B{sub 28}{sup −} borospherene is competing for the global minimum with a planar isomer and it is shown to be present in the cluster beam, contributing to the observed photoelectron spectrum. The seashell structure is found to be the global minimum for neutral B{sub 28} and the B{sub 28}{sup −} cage represents the smallest borospherene observed to date. It is composed of two triangular close-packed B{sub 15} sheets, interconnected via the three corners by sharing two boron atoms. The B{sub 28} borospherene was found to obey the 2(n + 1){sup 2} electron-counting rule for spherical aromaticity.

Degradation of 2,4-DB in Argentinean agricultural soils with high humic matter content.

Science.gov (United States)

Cuadrado, Virginia; Merini, Luciano J; Flocco, Cecilia G; Giulietti, Ana M

2008-01-01

The dissipation of 4-(2,4-dichlorophenoxy) butyric acid (2,4-DB) in high-humic-matter-containing soils from agricultural fields of the Argentinean Humid Pampa region was studied, employing soil microcosms under different experimental conditions. The added herbicide was dissipated almost completely by soils with and without history of herbicide use by day 28. At 500 ppm, both soils showed the same degradation rates; but at 5-ppm concentration, the chronically exposed soil demonstrated a faster degradation of the herbicide. 2,4-DB addition produced increases in herbicide-degrading bacteria of three and 1.5 orders of magnitude in soils with and without history of herbicide use, respectively, in microcosms with 5 ppm. At 500-ppm concentration, the increase in 2,4-DB degraders was five orders of magnitude after 14 days, independent of the history of herbicide use. No differences were observed in either 2,4-DB degradation rates or in degrader bacteria numbers in the presence and absence of alfalfa plants, in spite of some differential characteristics in patterns of 2,4-DB metabolite accumulation. The main factor affecting 2,4-DB degradation rate would be the history of herbicide use, as a consequence of the adaptation of the indigenous microflora to the presence of herbicides in the field.

TBC1D24 genotype-phenotype correlation: Epilepsies and other neurologic features.

Science.gov (United States)

Balestrini, Simona; Milh, Mathieu; Castiglioni, Claudia; Lüthy, Kevin; Finelli, Mattea J; Verstreken, Patrik; Cardon, Aaron; Stražišar, Barbara Gnidovec; Holder, J Lloyd; Lesca, Gaetan; Mancardi, Maria M; Poulat, Anne L; Repetto, Gabriela M; Banka, Siddharth; Bilo, Leonilda; Birkeland, Laura E; Bosch, Friedrich; Brockmann, Knut; Cross, J Helen; Doummar, Diane; Félix, Temis M; Giuliano, Fabienne; Hori, Mutsuki; Hüning, Irina; Kayserili, Hulia; Kini, Usha; Lees, Melissa M; Meenakshi, Girish; Mewasingh, Leena; Pagnamenta, Alistair T; Peluso, Silvio; Mey, Antje; Rice, Gregory M; Rosenfeld, Jill A; Taylor, Jenny C; Troester, Matthew M; Stanley, Christine M; Ville, Dorothee; Walkiewicz, Magdalena; Falace, Antonio; Fassio, Anna; Lemke, Johannes R; Biskup, Saskia; Tardif, Jessica; Ajeawung, Norbert F; Tolun, Aslihan; Corbett, Mark; Gecz, Jozef; Afawi, Zaid; Howell, Katherine B; Oliver, Karen L; Berkovic, Samuel F; Scheffer, Ingrid E; de Falco, Fabrizio A; Oliver, Peter L; Striano, Pasquale; Zara, Federico; Campeau, Phillipe M; Sisodiya, S M

2016-07-05

To evaluate the phenotypic spectrum associated with mutations in TBC1D24. We acquired new clinical, EEG, and neuroimaging data of 11 previously unreported and 37 published patients. TBC1D24 mutations, identified through various sequencing methods, can be found online (http://lovd.nl/TBC1D24). Forty-eight patients were included (28 men, 20 women, average age 21 years) from 30 independent families. Eighteen patients (38%) had myoclonic epilepsies. The other patients carried diagnoses of focal (25%), multifocal (2%), generalized (4%), and unclassified epilepsy (6%), and early-onset epileptic encephalopathy (25%). Most patients had drug-resistant epilepsy. We detail EEG, neuroimaging, developmental, and cognitive features, treatment responsiveness, and physical examination. In silico evaluation revealed 7 different highly conserved motifs, with the most common pathogenic mutation located in the first. Neuronal outgrowth assays showed that some TBC1D24 mutations, associated with the most severe TBC1D24-associated disorders, are not necessarily the most disruptive to this gene function. TBC1D24-related epilepsy syndromes show marked phenotypic pleiotropy, with multisystem involvement and severity spectrum ranging from isolated deafness (not studied here), benign myoclonic epilepsy restricted to childhood with complete seizure control and normal intellect, to early-onset epileptic encephalopathy with severe developmental delay and early death. There is no distinct correlation with mutation type or location yet, but patterns are emerging. Given the phenotypic breadth observed, TBC1D24 mutation screening is indicated in a wide variety of epilepsies. A TBC1D24 consortium was formed to develop further research on this gene and its associated phenotypes. © 2016 American Academy of Neurology.

: tous les projets | Page 398 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Date de début : 30 septembre 2008. End Date: 30 novembre 2010 ... Aider les jeunes adultes touchés par la violence à surmonter leurs traumatismes - phase ... Sujet: ETHNIC MINORITIES, ETHNIC CONFLICTS, PSYCHOLOGICAL ASPECTS.

4 CFR 22.24 - Alternative Dispute Resolution [Rule 24].

Science.gov (United States)

2010-01-01

... 4 Accounts 1 2010-01-01 2010-01-01 false Alternative Dispute Resolution [Rule 24]. 22.24 Section... GOVERNMENT ACCOUNTABILITY OFFICE CONTRACT APPEALS BOARD § 22.24 Alternative Dispute Resolution [Rule 24]. (a) Docketed appeals. The Board considers Alternative Dispute Resolution (ADR) to be an efficient way to timely...

27 CFR 28.291 - Customs Form 6001.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Customs Form 6001. 28.291... OF THE TREASURY LIQUORS EXPORTATION OF ALCOHOL Proceedings at Ports of Export Customs Gauge § 28.291 Customs Form 6001. When spirits or wines are gauged as required in §§ 28.264, 28.285, or 28.290, the...

La surveillance des abords vasculaires chez les hémodialysés ...

African Journals Online (AJOL)

La fistule artério veineuse a présenté très peu de complications chez les patients. Mots clés : Abord vasculaire, Hémodialyse, insuffisance rénale chronique. English abstract. Monitoring of vascular access in chronic hemodialysis patients at the National Hospital of Niamey Lamordé The purpose of this cross-sectional study ...

46 CFR 28.565 - Water on deck.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Water on deck. 28.565 Section 28.565 Shipping COAST... VESSELS Stability § 28.565 Water on deck. (a) Each vessel with bulwarks must comply with the requirements... energy, “b” in Figure 28.565, must not be less than the water on deck heeling energy, “a” in Figure 28...

Cross sections measurements for the forward elastic scattering of 13 MeV 6,7 Li and 24 MeV 16 O by 9 Be, 12 C, 16 O and 28 Si

International Nuclear Information System (INIS)

Liendo, J.A.; Gonzalez, A.C.; Fletcher, N.R.; Caussyn, D.D.

2001-01-01

Full text: Absolute elastic cross sections have been measured for targets of 9 Be, 12 C 16 O, 28 Si and 197 Au being bombarded by beams of 13 MeV 6 7 Li and 24 MeV 16 O. The relevant yields were collected simultaneously at 12.450, 16.450, 20.450 and 280. The confidence of a forward elastic scattering method proposed previously to carry out multi-elemental analysis of evaporated liquid samples depends on the precision and accuracy of the cross sections reported in this work.The 24 MeV 16 0 + 197 Au reaction was used to determine the detector solid angles with uncertainties of approximately 3%. Some of the 16 O-beam reactions Some of the 16 O beam reactions have been shown to be consistent with the Rutherford formula predictions at several angles. This allowed us to obtain target thickness independent cross sections for the lithium beam initiated reactions with uncertainties close to 7%. In general, the 6 7 Li-beam reaction cross sections were found not to be consistent with the Coulomb scattering formula. In order to test the internal consistency of our measured cross sections, they were used to determine the elemental densities of several selected targets containing beryllium, carbon, oxygen and silicon. These targets were bombarded with the same beam types and energies used to measure the cross sections and, for every element of interest contained in each target, elemental density values were obtained at some of the scattering angles quoted above. Agreements between some of our results and those of a previous work support the validity of our measurements. (Author)

AR mutations in 28 patients with androgen insensitivity syndrome (Prader grade 0-3).

Science.gov (United States)

Wang, Yi; Gong, Chunxiu; Wang, Xiou; Qin, Miao

2017-07-01

We investigated the androgen receptor (AR) gene mutation profiles of Chinese patients exhibiting severe androgen insensitivity syndrome (AIS) phenotypes. The present study enrolled 28 patients with genetically diagnosed AIS, who presented with severe phenotypes (Prader grade 0-3). Patients and some family members were screened via amplification and sequencing of their AR exons 1-8, including the corresponding intronic flanking regions. Luteinizing (LH), follicle-stimulating (FSH), and testosterone (T) hormone levels were found to be slightly, but not significantly, higher in patients with complete androgen insensitivity syndrome (CAIS) than in patients with partial androgen insensitivity syndrome (PAIS) (P>0.05). We identified 24 different AR mutations, including 12 that were novel. Ten patients (cases 2, 3, 10, 28, 11, 12, 19, 20, 24, and 25) were found to carry five recurrent mutations (p.Y572S, p.P914S, p.S176R, p.Y782N, and p.R841H); of these, p.Y572S, p.S176R, and p.Y782N were novel. Among the mutations identified in patients with CAIS, six (66.7%) were characterized as single-nucleotide missense mutations, and six (66.7%) were found to be located in the AR ligand-binding domain (LBD). Among the mutations identified in patients with PAIS, 15 (93.8%) were found to be missense, and 11 (68.8%) were found to be located in the LBD. Patients 10 and 28 were determined to harbor the same missense mutation (p.P914S), but were diagnosed with CAIS and PAIS, respectively. Sex hormone levels were slightly, but not significantly, elevated in patients with CAIS compared to those with PAIS. Missense mutations spanning AR exons 1-8 were the predominant form of identified mutations, and these were mostly located in the AR LBD. Approximately 50% of the identified mutations were novel, and have enriched the AR gene-mutation database. Patients harboring identical mutations were in some instances found to exhibit divergent phenotypes.

Recombinant rubistatin (r-Rub), an MVD disintegrin, inhibits cell migration and proliferation, and is a strong apoptotic inducer of the human melanoma cell line SK-Mel-28.

Science.gov (United States)

Carey, Clayton M; Bueno, Raymund; Gutierrez, Daniel A; Petro, Christopher; Lucena, Sara E; Sanchez, Elda E; Soto, Julio G

2012-02-01

Disintegrins are low molecular weight peptides isolated from viper venom. These peptides bind to integrin receptors using a conserved binding motif sequence containing an RGD or similar motif. As a consequence, disintegrins can inhibit platelet aggregation and inhibit cell migration, proliferation, and initiate apoptosis in cancer cell lines. Rubistatin is a MVD disintegrin cloned from a Crotalus ruber ruber venom gland. The biological activity of MVD disintegrins is poorly understood. Recombinant rubistatin (r-Rub) was cloned into a pET32b plasmid and expressed in reductase-deficient Escherichia coli. Expression was induced with IPTG and the resulting fusion peptide was affinity purified, followed by thrombin cleavage, and removal of vector coded sequences. r-Rub peptide inhibited ADP-induced platelet aggregation by 54% ± 6.38 in whole blood. We assessed the ability of r-Rub to initiate apoptosis in three human cancer cell lines. Cultures of SK-Mel-28, HeLA, and T24 cells were grown for 24 h with 2.5 μM r-Rub followed by Hoechst staining. Chromatin fragmentation was observed in treated SK-Mel-28, but not in T24 or HeLA cells. A TUNEL assay revealed that 51.55% ± 5.28 of SK-Mel-28 cells were apoptotic after 18 h of treatment with 3.5 μM of r-Rub. Cell migration and proliferation assays were performed in order to further characterize the biological effects of r-Rub on SK-Mel-28 cells. At 3 μM, r-Rub inhibited cell migration by 44.4% ± 0.5, while at 3.5 μM it was able to inhibit cell proliferation by 83% ± 6.0. Copyright © 2011 Elsevier Ltd. All rights reserved.

49 CFR 393.28 - Wiring systems.

Science.gov (United States)

2010-10-01

... 49 Transportation 5 2010-10-01 2010-10-01 false Wiring systems. 393.28 Section 393.28 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY... NECESSARY FOR SAFE OPERATION Lamps, Reflective Devices, and Electrical Wiring § 393.28 Wiring systems...

7 CFR 28.911 - Review classification.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Review classification. 28.911 Section 28.911... REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Cotton Classification and Market News Service for Producers Classification § 28.911 Review classification. (a) A producer may request one review...

Bourse de recherche : Innovation en matière de vaccins pour le bétail

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6 sept. 2017 ... Date butoir : le 6 septembre 2017 Prière de noter que toutes les demandes doivent être présentées en ligne. Cette bourse de recherche est accessible uniquement aux citoyens kenyans.

7 CFR 1700.28 - Electric Program.

Science.gov (United States)

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Electric Program. 1700.28 Section 1700.28 Agriculture... GENERAL INFORMATION Agency Organization and Functions § 1700.28 Electric Program. RUS, through the Electric Program, makes loans and loan guarantees for rural electrification and the furnishing of electric...

22 CFR 62.28 - International visitors.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false International visitors. 62.28 Section 62.28 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES EXCHANGE VISITOR PROGRAM Specific Program Provisions § 62.28 International visitors. (a) Purpose. The international visitor category is for...

7 CFR 28.121 - Advance deposits.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Advance deposits. 28.121 Section 28.121 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing..., TESTING, AND STANDARDS Regulations Under the United States Cotton Standards Act Fees and Costs § 28.121...

29 CFR 785.28 - Involuntary attendance.

Science.gov (United States)

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Involuntary attendance. 785.28 Section 785.28 Labor... POLICY OR INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS HOURS WORKED Application of Principles Lectures, Meetings and Training Programs § 785.28 Involuntary attendance. Attendance is not voluntary, of...

31 CFR 357.28 - Transaction requests.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Transaction requests. 357.28 Section 357.28 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL... System (Legacy Treasury Direct) § 357.28 Transaction requests. (a) General. Unless otherwise authorized...

49 CFR 28.110 - Self-evaluation.

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Self-evaluation. 28.110 Section 28.110 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION § 28.110 Self-evaluation...

49 CFR 28.170 - Compliance procedures.

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Compliance procedures. 28.170 Section 28.170 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION § 28.170 Compliance...

Analysis list: nhr-28 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available nhr-28 Embryo,Larvae + ce10 http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/...nhr-28.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/nhr-28.5.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/ce10/target/nhr-28.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/nhr-28.Embryo....tsv,http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/nhr-28.Larvae.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/ce10/colo/Embryo.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/Larvae.gml ...

46 CFR 28.73 - Accepted organizations.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Accepted organizations. 28.73 Section 28.73 Shipping... INDUSTRY VESSELS General Provisions § 28.73 Accepted organizations. An organization desiring to be designated by the Commandant as an accepted organization must request such designation in writing. As a...

7 CFR 28.904 - Market news.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Market news. 28.904 Section 28.904 Agriculture..., TESTING, AND STANDARDS Cotton Classification and Market News Service for Producers Classification and Market News Services § 28.904 Market news. The Director shall cause to be distributed to producers of...

GAC-EPA

CERN Multimedia

GAC-EPA

2017-01-01

Le GAC organise des permanences avec entretiens individuels qui se tiennent le dernier mardi de chaque mois, sauf en juin, juillet et décembre. La prochaine permanence se tiendra le : Mardi 26 septembre de 13 h 30 à 16 h 00 Salle de réunion de l’Association du personnel Les permanences suivantes auront lieu les mardis 31 octobre et 28 novembre 2017. Les permanences du Groupement des Anciens sont ouvertes aux bénéficiaires de la Caisse de pensions (y compris les conjoints survivants) et à tous ceux qui approchent de la retraite. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association du personnel, les documents nécessaires. Informations : http://gac-epa.org/ Formulaire de contact : http://gac-epa.org/Organization/ContactForm/ContactForm-fr.php

7 CFR 28.403 - Middling Color.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Middling Color. 28.403 Section 28.403 Agriculture..., TESTING, AND STANDARDS Standards Official Cotton Standards of the United States for the Color Grade of American Upland Cotton § 28.403 Middling Color. Middling Color is color which is within the range...

46 CFR 28.580 - Unintentional flooding.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Unintentional flooding. 28.580 Section 28.580 Shipping... INDUSTRY VESSELS Stability § 28.580 Unintentional flooding. (a) Applicability. Except for an open boat that... survive the assumed damage and unintentional flooding described in paragraphs (d) and (e) of this section...

27 CFR 28.216 - Export marks.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.216 Section 28.216 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS EXPORTATION OF ALCOHOL Exportation of Wine With Benefit of Drawback § 28.216...

4 CFR 28.122 - Negotiability issues.

Science.gov (United States)

2010-01-01

... 4 Accounts 1 2010-01-01 2010-01-01 false Negotiability issues. 28.122 Section 28.122 Accounts... Special Procedures; Unfair Labor Practices § 28.122 Negotiability issues. Where the GAO and an exclusive... shall review the arguments, hold a hearing if the administrative judge deems it necessary, and issue a...

Des batisseurs d'univers creent au CERN de minuscules antimondes

CERN Multimedia

2003-01-01

"Apres des annees de travail des physiciens du CERN en creant artificiellement des dizaines de milliers de minuscules antimondes - des atomes d'antihydrogene - dont la revue Nature rend compte dans son edition du 18 septembre 2002" (1 page).

Di-lepton yield from the decay of excited 28Si states

International Nuclear Information System (INIS)

Bacelar, J.C.; Buda, A.; Balanda, A.; Krasznahorkay, A.; Ploeg, H. van der; Sujkowski, Z.; Woude, A. van der

1994-01-01

The first dilepton yield measurements from excited nuclear states obtained with a new Positron-Electron Pair Spectroscopic Instrument (PEPSI) are reported. Nuclear states in 28 Si, with an initial excitation energy E * =50 MeV, were populated via the isospin T=0 reaction 4 He+ 24 Mg and the mixed-isospin 3 He+ 25 Mg reaction. In both reactions the dilepton (e + e - ) and photon decay yields were measured concurrently. An excess of counts in the e + e - spectrum, over the converted photon yield, is observed in the energy region above 15 MeV. An analyses is discussed whereby the observed excess counts are assumed to represent the isoscalar E0 strength in excited nuclear states. (orig.)

Reactor neutron activation analysis for aluminium in the presence of phosphorus and silicon. Contributions of /sup 28/Al activities from /sup 31/P (n,. cap alpha. ) /sup 28/Al and /sup 28/Si (n,p) /sup 28/Al reactions

Energy Technology Data Exchange (ETDEWEB)

Mizumoto, Yoshihiko (Kinki Univ., Higashi-Osaka, Osaka (Japan). Faculty of Science and Technology); Iwata, Shiro; Sasajima, Kazuhisa; Yoshimasu, Fumio; Yase, Yoshiro

1984-01-01

Reactor neutron activation analysis for aluminium in samples containing phosphorus and silicon was studied. The experiments were performed by using pneumatic tube of the Kyoto University Reactor (KUR). At first, the ratios of the /sup 28/Al activity produced from /sup 27/Al(n, ..gamma..) /sup 28/Al reaction by thermal neutrons to that from /sup 31/P(n, ..cap alpha..)/sup 28/Al reaction by fast neutrons, and to that from /sup 28/Si(n, p)/sup 28/Al reaction were measured by ..gamma..-ray spectrometry. With a ratio of about 5 for the thermal to fast neutron flux of KUR, the ratio of the /sup 28/Al activity from aluminium to that from phosphorus was to be 812 +- 7, and to that from silicon 282 +- 3. Secondly, the contributions of /sup 28/Al activities from phosphorus and silicon and the determination limit of aluminium were calculated for various parameters, such as fast neutron flux, thermal to fast neutron flux ratio, amounts of phosphorus and silicon, etc. Thirdly, on the basis of these results, aluminium contents in spinal cords and brains of amyotrophic lateral sclerosis, Parkinsonism-dementia complex and control cases were determined.

5 CFR 2422.28 - Runoff elections.

Science.gov (United States)

2010-01-01

... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Runoff elections. 2422.28 Section 2422.28... FEDERAL LABOR RELATIONS AUTHORITY REPRESENTATION PROCEEDINGS § 2422.28 Runoff elections. (a) When a runoff may be held. A runoff election is required in an election involving at least three (3) choices, one of...

46 CFR 28.335 - Fuel systems.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Fuel systems. 28.335 Section 28.335 Shipping COAST GUARD... Than 16 Individuals on Board § 28.335 Fuel systems. (a) Applicability. Except for the components of an...) Portable fuel systems. Portable fuel systems including portable tanks and related fuel lines and...

31 CFR 28.525 - Fringe benefits.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Fringe benefits. 28.525 Section 28... the Basis of Sex in Employment in Education Programs or Activities Prohibited § 28.525 Fringe benefits. (a) “Fringe benefits” defined. For purposes of these Title IX regulations, fringe benefits means: Any...

19 CFR 111.28 - Responsible supervision.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Responsible supervision. 111.28 Section 111.28 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CUSTOMS BROKERS Duties and Responsibilities of Customs Brokers § 111.28 Responsible supervision. (a) General. Every individual broker...

Search for the Higgs Boson and for Anomalous Quartic Gauge Boson Couplings in the WW Channel with Dielectron Events with the D0 Experiment at the Tevatron; Recherche du boson de Higgs et de couplages de jauge quartiques anormaux dans le canal WW en électrons dans l'expérience D0 au Tevatron

Energy Technology Data Exchange (ETDEWEB)

Chapon, Emilien [Pierre and Marie Curie Univ., Paris (France)

2013-01-01

Le paysage de la physique des particules a subi des changements majeurs entre le début de cette thèse, en septembre 2010, et sa n en juin 2013. On peut notamment qualier l'année 2012 de date-clé dans l'histoire de la physique des particules. En 2012, une nouvelle particule a été découverte au LHC [1, 2], dont la majeure partie de la communauté s'accorde aujourd'hui à dire qu'il s'agit très probablement du boson de Higgs. Cet événement est intervenu peu après une sorte de passage de relais entre le Tevatron, arrêté le 30 septembre 2011, et le LHC, dont les toutes premières collisions sont intervenues le 23 novembre 2009.

27 CFR 28.28 - Withdrawal of wine and distilled spirits from customs bonded warehouses.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Withdrawal of wine and... Miscellaneous Provisions Customs Bonded Warehouses § 28.28 Withdrawal of wine and distilled spirits from customs bonded warehouses. Wine and bottled distilled spirits entered into customs bonded warehouses as provided...

Communication dated 28 September 2005 from the Permanent Mission of the Islamic Republic of Iran to the Agency

International Nuclear Information System (INIS)

2005-01-01

The Secretariat has received a Note Verbale dated 28 September 2005 from the Permanent Mission of the Islamic Republic of Iran, attaching two statements of the Delegation of the Islamic Republic of Iran delivered during the meetings of the Board of Governors on 22 and 24 September 2005. The Note Verbale and, as requested therein, its attachments are herewith circulated as an Information Circular

Communication dated 28 September 2005 from the Permanent Mission of the Islamic Republic of Iran to the Agency

Energy Technology Data Exchange (ETDEWEB)

NONE

2005-10-19

The Secretariat has received a Note Verbale dated 28 September 2005 from the Permanent Mission of the Islamic Republic of Iran, attaching two statements of the Delegation of the Islamic Republic of Iran delivered during the meetings of the Board of Governors on 22 and 24 September 2005. The Note Verbale and, as requested therein, its attachments are herewith circulated as an Information Circular.

46 CFR 28.835 - Fuel systems.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Fuel systems. 28.835 Section 28.835 Shipping COAST GUARD... Aleutian Trade Act Vessels § 28.835 Fuel systems. (a) Portable fuel systems including portable tanks and... impurities from diesel fuel oil systems are permitted in the machinery space provided they are away from any...

Synthesis of 24S and 24R-hydroxy-[24-3H] vitamin D3 and their metabolism in rachitic rats

International Nuclear Information System (INIS)

Tanaka, Y.; DeLuca, H.F.; Akaiwa, A.; Morisaki, M.; Ikekawa, N.

1976-01-01

An epimeric mixture of 24-hydroxy-[24- 3 H] vitamin D 3 was synthesized by the reduction of 24-ketovitamin D 3 by sodium borotritide. The epimeric mixture was converted to the trimethylsilylether derivatives and subjected to high-pressure liquid chromatography using silica gel columns to separate the 24-hydroxy-[24- 3 H] vitamin D 3 isomers. The 24R-hydroxy-[24- 3 H]vitamin D 3 induced calcification in rachitic rats while the 24S-hydroxy-[24- 3 H]vitamin D 3 had little or no such activity. As both isomers of 24-hydroxy-vitamin D 3 are metabolized to 24,25-dihydroxyvitamin D 3 , it appears that the 24-hydroxyvitamin D 3 -25-hydroxylase does not discriminate between the isomers. Only the R-isomer of 24-hydroxyvitamin D 3 is metabolized to 1,24-dihydroxyvitamin D 3 , although only trace amounts of this compound were found 2 days after the administration of 24-hydroxyvitamin D 3 . The striking difference in the metabolism of the isomers is the high selectivity of the 1-hydroxylase for the R-isomer. It is suggested that the high specificity of biological activity for the R-isomer of 24-hydroxyvitamin D 3 is because of the specificity of the 1-hydroxylation of 24,25-dihydroxyvitamin D 3 for the R configuration

: tous les projets | Page 376 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

End Date: 30 septembre 2015. Sujet: INFECTIOUS DISEASES, ZOONOSES, EPIDEMICS, DISEASE TRANSMISSION, DISEASE VECTORS, Disease control, REGIONAL COOPERATION. Région: South Asia, North of Sahara, South of Sahara, Central Asia, Far East Asia, Egypt. Programme: Alimentation, environnement et ...

Induction September 2014

CERN Multimedia

Photo Service, CERN

2014-01-01

On Tuesday 23 September 2014, recently-recruited staff members and fellows were welcomed Le Mardi 23 septembre 2014, les membres du personnel titulaires et boursiers récemment recrutés par le CERN ont été accueillis

20 CFR 218.28 - Sick pay.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Sick pay. 218.28 Section 218.28 Employees... Beginning Date § 218.28 Sick pay. (a) From railroad employer. If the employee is carried on the payroll while sick, the annuity can begin no earlier than the day after the last day of sick pay. However, sick...

46 CFR 28.885 - Cargo gear.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Cargo gear. 28.885 Section 28.885 Shipping COAST GUARD... Aleutian Trade Act Vessels § 28.885 Cargo gear. (a) The safe working load (SWL) for the assembled gear... the load the gear is approved to lift, excluding the weight of the gear itself. (b) All wire rope...

14 CFR 1260.28 - Patent rights.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Patent rights. 1260.28 Section 1260.28... Provisions § 1260.28 Patent rights. Patent Rights May 2006 As stated at § 1260.136, this award is subject to... “Patent Rights (Small Business Firms and Nonprofit Organizations)” and the following: (a) Where the term...

Effect of fractionated radiotherapy using a hypoxic cell radiosensitizer, RK-28, on experimental murine tumor

International Nuclear Information System (INIS)

Tanaka, Shukaku

1990-01-01

The effect of a hypoxic cell radiosensitizer RK-28, on fractionated radiotherapy was studied using mice with implanted tumors. Experimental animal tumors were third generation isoplants of a mammary carcinoma which arose spontaneously in a C 3 H/He mouse. RK-28 was given to the mice at two dosages: 0.4 mg/g,b.wt. and 0.2 mg/g.b.wt. Total dose of irradiation was 20 Gy which was divided into the first 10 Gy irradiation and the second 10 Gy performed after a proper time interval such as 1, 24, 48 and 72 hours after the first 10 Gy irradiation. Tumor growth was evaluated by TGT 50 /3 times, which was defined as the time required for 50% of the tumors to regrow to the 3 times value of its initial volume. Tumor volume was measured every day and TGT 50 /3 times was calculated by logit analysis method. No significant differences were found in the TGT 50 /3 times among the groups treated by radiation alone, those treated by RK-administration alone and those without any treatment. TGT 50 value of control group without any treatment was 3.40 (days). TGT 50 value of another group treated by RK-28 alone was 3.46. and TGT 50 value of 20 Gy X-ray irradiation alone was 10.23. Under the fractionated X-ray irradiation alone, TGT 50 values of the various time interval such as 9, 14, 48 and 72 hours were 11.26, 10.42, 12.14 and 1.10. Under the combined treatment of the fractionated X-ray irradiation and RK-28 administration, TGT 50 values were 17.84, 16.42, 16.59 and 17.49. These TGT 50 /3 times values showed that RK-28 had a radiosensitizing effect when given with fractionated radiotherapy even at lower doses of RK-28 administration and radiation. Therefore, it was suggested that fractionated radiotherapy using RK-28 was useful in the cancer treatment. (author) 52 refs

Images in medicine

African Journals Online (AJOL)

ebutamanya

2016-01-05

Jan 5, 2016 ... 1Service de Pédiatrie, CHU Hassan II, Fès, Maroc, 2Département de Médecine et Spécialités Médicales, FSS, Université Abdou Moumouni de. Niamey, Niger. &Corresponding author: Djafar Mamoudou, Service de Pédiatrie, CHU Hassan II, Fès, Maroc, Département de Médecine et Spécialités Médicales,.

Bourse de recherche : Alimentation, environnement et santé | CRDI ...

International Development Research Centre (IDRC) Digital Library (Canada)

6 sept. 2017 ... Date butoir : le 6 septembre 2017 Prière de noter que toutes les demandes doivent ... et ultra transformées, qui sont pauvres sur le plan nutritionnel. ... le marketing social ou les changements de comportements individuels; ...

Page 28

African Journals Online (AJOL)

ezra

7 (2)2007. Page 28. Serials Management In Polytechnic Libraries in Nigeria: A Comparative ... Despite the strategic position of serials publications amongst the materials .... the formulation of routines and procedures for ..... other professional librarian in the section classify ... probably due to dwindling finance given to both.

The merging of the islands of inversion at N=20 and N=28

CERN Document Server

Caurier, Etienne; Poves, Alfredo

2014-01-01

The N=20 and N=28 "islands of inversion" are described by large scale shell model calculations with an extension of the interaction sdpf-u that makes it possible to mix configurations with different Nhw or equivalently with different number of particles promoted from the sd-shell to the pf-shell. It allows to connect the classical sd-shell calculations below N=18 with the sd(protons)-pf(neutrons) calculations beyond N=24-26, for all the isotopes from Oxygen to Calcium, using the same interaction. For some isotopes this range contains all the nuclei between the proton and the neutron drip lines and includes the N=20 and N=28 islands of inversion. We shall pay particular attention to the properties of the states at fix Nhw which turn out to be the real protagonists of the physics at N=20. The existence of islands of inversion/deformation will be explained as the result of the competition between the spherical mean field which favors the 0hw configurations and the nuclear correlations which favor the deformed Nh...

Wobbling excitation of triaxial nuclear molecule 28Si – 28Si

International Nuclear Information System (INIS)

Uegaki, E; Abe, Y

2013-01-01

High-spin resonances observed in the 28 Si + 28 Si collisions are investigated with a molecular model. At high spins, a stable dinuclear configuration is found to be an equator-equator touching one. Since the E-E configuration is slightly triaxial, rotations of the total system induce mixing of K quantum numbers, called wobbling motion, which clearly explains the particle-γ angular correlations observed as well as the disalignments in a simple and natural way. Furthermore, predictions are given for the angular correlations of the wobbling excited states. The first excited state of wobbling shows strong alignments, which is quite different from the molecular ground state.

28 CFR 513.31 - Limitations.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Limitations. 513.31 Section 513.31 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE GENERAL MANAGEMENT AND ADMINISTRATION... published in 5 CFR part 297 and by Department of Justice regulations published in 28 CFR part 16. ...

31 CFR 28.500 - Employment.

Science.gov (United States)

2010-07-01

... benefits of, or be subjected to discrimination in employment, or recruitment, consideration, or selection... §§ 28.500 through 28.550 apply to: (1) Recruitment, advertising, and the process of application for...-sponsored activities, including social or recreational programs; and (10) Any other term, condition, or...

7 CFR 28.162 - Procedure.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Procedure. 28.162 Section 28.162 Agriculture..., TESTING, AND STANDARDS Regulations Under the United States Cotton Standards Act Adjustment of Contract... and in instituting and conducting arbitrations and appeals shall be as prescribed in the articles...

7 CFR 28.183 - Fees and costs; payment.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Fees and costs; payment. 28.183 Section 28.183... REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Classification for Foreign Growth Cotton § 28.183 Fees and costs; payment. The provisions of §§ 28.115 through 28.126 relating to fees, costs, and method of...

21 CFR 660.28 - Labeling.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Labeling. 660.28 Section 660.28 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS ADDITIONAL... change, precipitate, that may indicate possible deterioration of the product. (c) Package insert. Each...

33 CFR 83.24 - Towing and pushing (Rule 24).

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Towing and pushing (Rule 24). 83... NAVIGATION RULES RULES Lights and Shapes § 83.24 Towing and pushing (Rule 24). (a) A power-driven vessel when... it can best be seen. (b) Pushing vessel and pushed vessel rigidly connected in composite unit. When a...

Proteasome Activators, PA28α and PA28β, Govern Development of Microvascular Injury in Diabetic Nephropathy and Retinopathy

Directory of Open Access Journals (Sweden)

Saeed Yadranji Aghdam

2016-01-01

Full Text Available Diabetic nephropathy (DN and diabetic retinopathy (DR are major complications of type 1 and type 2 diabetes. DN and DR are mainly caused by injury to the perivascular supporting cells, the mesangial cells within the glomerulus, and the pericytes in the retina. The genes and molecular mechanisms predisposing retinal and glomerular pericytes to diabetic injury are poorly characterized. In this study, the genetic deletion of proteasome activator genes, PA28α and PA28β genes, protected the diabetic mice in the experimental STZ-induced diabetes model against renal injury and retinal microvascular injury and prolonged their survival compared with wild type STZ diabetic mice. The improved wellbeing and reduced renal damage was associated with diminished expression of Osteopontin (OPN and Monocyte Chemoattractant Protein-1 (MCP-1 in the glomeruli of STZ-injected PA28α/PA28β double knockout (Pa28αβDKO mice and also in cultured mesangial cells and retinal pericytes isolated from Pa28αβDKO mice that were grown in high glucose. The mesangial PA28-mediated expression of OPN under high glucose conditions was suppressed by peptides capable of inhibiting the binding of PA28 to the 20S proteasome. Collectively, our findings demonstrate that diabetic hyperglycemia promotes PA28-mediated alteration of proteasome activity in vulnerable perivascular cells resulting in microvascular injury and development of DN and DR.

INCLUSIVE SYSTEMATICS FOR SI-28+SI-28 REACTIONS BETWEEN 20 AND 35 MEV PER NUCLEON

NARCIS (Netherlands)

BOX, PF; GRIFFIOEN, KA; DECOWSKI, P; BOOTSMA, T; GIERLIK, E; VANNIEUWENHUIZEN, GJ; TWENHOFEL, C; KAMERMANS, R; WILSCHUT, HW; GIORNI, A; MORAND, C; DEMEYER, A; GUINET, D

Inclusive velocity spectra of heavy ions produced in the Si-28 + Si-28 reaction at 22, 26, 30, and 35 MeV per nucleon were measured and decomposed into peripheral and central components using an analytical moving-source parametrization. The persistence of incomplete fusion followed by evaporation

Asymmetric fission of 47V induced by the 23Na+24Mg reaction

International Nuclear Information System (INIS)

Beck, C.; Djerroud, B.; Haas, F.; Freeman, R.M.; Hachem, A.; Heusch, B.; Morsad, A.; Vuillet-A-Cilles, M.; Sanders, S.J.

1993-01-01

The properties of fully energy-damped processes (deep-inelastic orbiting, fusion-evaporation, and fusion-fission processes) have been investigated in the nearly mass-symmetric entrance-channel 23 Na + 24 Mg reaction leading to the 47 V compound nucleus. By comparison with previous data for the mass-asymmetric 35 Cl + 12 C reaction forming the same compound system at the same excitation energy, no entrance-channel effects are observed in either the evaporation residue or the fusion-fission yields. This is in contrast to the situation with the 28 Si + 12 C and 24 Mg + 16 O reactions where an orbiting process is evident. The asymmetrical elemental distributions of the fusion-fission fragments of the massA=47 system are well described by a transition-state model that accounts for the spin and mass-asymmetry dependence of the fission saddle point

Support for higher ciprofloxacin AUC 24/MIC targets in treating Enterobacteriaceae bloodstream infection.

Science.gov (United States)

Zelenitsky, Sheryl A; Ariano, Robert E

2010-08-01

Given concerns regarding optimal therapy for serious Gram-negative infections, the goal was to characterize the pharmacodynamics of ciprofloxacin in the context of treating bloodstream infection. Data were collected from the medical records of 178 clinical cases. Blood isolates were retrieved and ciprofloxacin MICs were measured. Forty-two cases in which ciprofloxacin was initiated within 24 h of the positive blood culture were used in the pharmacodynamic analysis. Significant factors with regard to treatment failure were low ciprofloxacin AUC(24)/MIC (P AUC(24) (P = 0.01). AUC(24)/MIC (P = 0.012) and MIC (P = 0.019) were significant variables in multivariate analyses; however, only the former remained significant (P = 0.038) after excluding two cases with ciprofloxacin-resistant isolates. An AUC(24)/MIC breakpoint of 250 was most significant, with cure rates of 91.4% (32/35) and 28.6% (2/7) in patients with values above and below this threshold, respectively (P = 0.001). The risk of ciprofloxacin treatment failure was 27.8 times (95% confidence interval, 2.1-333) greater in those not achieving an AUC(24)/MIC >or=250 (P = 0.011). Monte Carlo simulation of 5000 study subjects predicted that 0.88 of the population would achieve an AUC(24)/MIC >or=250 with standard-dose ciprofloxacin (400 mg intravenously every 12 h). This study confirms the pharmacodynamic parameters of ciprofloxacin that are important for optimizing the treatment of serious infections, particularly the benefits of achieving an AUC(24)/MIC >or=250, rather than the conventional target of >or=125. It also shows the relevance of dose selection in optimizing target attainment, with important differences among pathogens, even those with MICs within the susceptible range.

27 CFR 28.94 - Containers.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Containers. 28.94 Section... Manufacturing Bonded Warehouse § 28.94 Containers. Distilled spirits authorized to be withdrawn without payment... be withdrawn from such establishment in such containers as may be authorized in part 19 of this...

44 CFR 352.28 - Reimbursement.

Science.gov (United States)

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Reimbursement. 352.28 Section... Participation § 352.28 Reimbursement. In accordance with Executive Order 12657, Section 6(d), and to the extent permitted by law, FEMA will coordinate full reimbursement, either jointly or severally, to the agencies...

A randomized, masked study of triiodothyronine plus thyroxine administration in preterm infants less than 28 weeks of gestational age: Hormonal and clinical effects

NARCIS (Netherlands)

Valerio, Paolo G.; van Wassenaer, Aleid G.; de Vijlder, Jan J. M.; Kok, Joke H.

2004-01-01

A randomized, placebo-controlled, masked study was conducted of the responses of thyroid parameters, cortisol, and the cardiovascular system to a single dose of triiodothyronine (T-3) 24 h after birth, followed by a daily dose of thyroxine (T-4) during 6 wk to infants <28 wk gestational age.

Analysis of land degradation processes on a tiger bush plateau in South West Niger using MODIS and LANDSAT TM/ETM+ data

Science.gov (United States)

Fiorillo, Edoardo; Maselli, Fabio; Tarchiani, Vieri; Vignaroli, Patrizio

2017-10-01

Remote sensing digital image analysis has been applied to monitor land clearing and degradation processes on a plateau covered by tiger bush near Niamey in South West Niger, where signs of severe landscape degradation due to fuelwood supply have been observed in the last decades. A MODIS NDVI dataset (2000-2015) and five LANDSAT images (1986-2012) were used to identify spatial and temporal dynamics and to emphasize areas of greater degradation. The study indicates that the land clearing found by previous investigations in the second part of the 20th century is still ongoing, with a decreasing trend of MODIS NDVI values recorded in the period 2000-2015. This trend appeared to be linked to an increase in bare soil areas that was demonstrated by analysis of LANDSAT SAVI images. The investigation also indicated that rates of degradation are stronger in more deteriorated areas like those located nearer Niamey; degradation patterns also tend to increase from the inner areas to the edges of the plateau. These results attest to the urgency to develop effective environmental preservation policies and find alternative solutions for domestic energy supply.

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OpenAIRE

????????, ?????; ????????, ?????; ?????????, ?????; ??????, ??????

2011-01-01

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27 CFR 28.282 - Beer.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Beer. 28.282 Section 28.282 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE... Beer. When beer has been laden on board the aircraft for use as supplies, the customs officer shall...

31 CFR 28.620 - Hearings.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Hearings. 28.620 Section 28.620 Money and Finance: Treasury Office of the Secretary of the Treasury NONDISCRIMINATION ON THE BASIS OF SEX IN... Title IX regulations, but rules or principles designed to assure production of the most credible...

Sudan : tous les projets | Page 2 | CRDI - Centre de recherches pour ...

International Development Research Centre (IDRC) Digital Library (Canada)

End Date: 1 septembre 2013. Sujet: WOMEN'S RIGHTS, CIVIL RIGHTS, WOMEN'S PARTICIPATION, POLITICAL PARTICIPATION, GENDER EQUALITY, Gender. Région: Sudan, North of Sahara, South of Sahara. Programme: Gouvernance et justice. Financement total : CA$ 147,900.00. Les technologies de l'information et ...

Transnational Corporations and Local Innovation | CRDI - Centre de ...

International Development Research Centre (IDRC) Digital Library (Canada)

Transnational Corporations and Local Innovation. Couverture du livre Transnational Corporations and Local Innovation. Directeur(s) : José Cassiolato, Graziela Zucoloto, Dinesh Abrol et Liu Xielin. Maison(s) d'édition : Taylor and Francis, CRDI. 25 septembre 2013. ISBN : 9780415710381. 418 pages. e-ISBN :.

Enantiospecific tritium labeling of 28-homocastasterone.

Science.gov (United States)

Elbert, Tomáš; Patil, Mahadeo R; Marek, Aleš

2017-03-01

A regiospecific and enantiospecific synthesis of tritium-labeled 28-homocastasterone is reported. Appropriate chlorocarbonate, efficiently synthesized from the starting 28-homocastasterone in an overall yield of 46%, undergoes catalytic tritium dechlorination by the T 2 /Pd[0]/Et 3 N system, providing 28-[3β- 3 H]homocastasterone, in a good yield, radiochemical purity (>97%), and with a high specific activity (5.8 Ci/mmol). Copyright © 2016 John Wiley & Sons, Ltd.

The nematode homologue of Mediator complex subunit 28, F28F8.5, is a critical regulator of C. elegans development.

Science.gov (United States)

Kostrouchová, Markéta; Kostrouch, David; Chughtai, Ahmed A; Kaššák, Filip; Novotný, Jan P; Kostrouchová, Veronika; Benda, Aleš; Krause, Michael W; Saudek, Vladimír; Kostrouchová, Marta; Kostrouch, Zdeněk

2017-01-01

The evolutionarily conserved Mediator complex is a critical player in regulating transcription. Comprised of approximately two dozen proteins, the Mediator integrates diverse regulatory signals through direct protein-protein interactions that, in turn, modulate the influence of Mediator on RNA Polymerase II activity. One Mediator subunit, MED28, is known to interact with cytoplasmic structural proteins, providing a potential direct link between cytoplasmic dynamics and the control of gene transcription. Although identified in many animals and plants, MED28 is not present in yeast; no bona fide MED28 has been described previously in Caenorhabditis elegans. Here, we identify bioinformatically F28F8.5, an uncharacterized predicted protein, as the nematode homologue of MED28. As in other Metazoa, F28F8.5 has dual nuclear and cytoplasmic localization and plays critical roles in the regulation of development. F28F8.5 is a vital gene and its null mutants have severely malformed gonads and do not reproduce. F28F8.5 interacts on the protein level with the Mediator subunits MDT-6 and MDT-30. Our results indicate that F28F8.5 is an orthologue of MED28 and suggest that the potential to link cytoplasmic and nuclear events is conserved between MED28 vertebrate and nematode orthologues.

YOGA CLUB

CERN Document Server

CLUB DE YOGA

2010-01-01

DÉBUT DES COURS   mercredi 1er septembre 2010   (Yoga, Sophrologie, Tai Chi, Zen) Liste des cours pour le semestre allant du 1 er septembre 2010 au 31 janvier 2011. New: one course will be held in English Viniyoga (progressive and adaptable yoga, emphasis on breathing) Courses held in English Teacher: Marta Csatari 1 course per week Tuesday 12h15 – 13h30 Viniyoga (yoga progressif et adapté, appui sur la respiration) Professeur : Magali Roussel 2 cours hebdomadaires Lundi       11h15 – 12h30                12h30 – 13h45 (débutants) Hatha Yoga et yoga chinois (tonification musculaire) Professeur : Marie-Claude Pihet 2 cours hebdomadaires Mardi      17h30 – 18h30 &nb...

28 CFR 16.200 - Definitions.

Science.gov (United States)

2010-07-01

... action on behalf of the Commission where such deliberations determine or result in the joint conduct or... jurisdiction cases pursuant to 28 CFR 2.17(a); (4) Meetings of the entire Commission to determine original jurisdiction appeal cases pursuant to 28 CFR 2.27; and (5) Meetings of the National Appeals Board pursuant to...

31 CFR 28.515 - Compensation.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Compensation. 28.515 Section 28.515 Money and Finance: Treasury Office of the Secretary of the Treasury NONDISCRIMINATION ON THE BASIS OF... a rate less than that paid to employees of the opposite sex for equal work on jobs the performance...

Entrance channel excitations in the 28Si + 28Si reaction

International Nuclear Information System (INIS)

Decowski, P.; Gierlik, E.; Box, P.F.; Kamermans, R.; Nieuwenhuizen, G.J. van; Meijer, R.J.; Griffioen, K.A.; Wilschut, H.W.; Giorni, A.; Morand, C.; Demeyer, A.; Guinet, D.

1991-01-01

Velocity spectra of heavy ions produced in the 28 Si + 28 Si reaction at bombarding energies of 19.7 and 30 MeV/nucleon were measured and interpreted within the Q-optimum model extended by the inclusion of particle evaporation from excited fragments. Regions of forward angle spectra corresponding to the mutual excitation of the reaction partners with net mass transfer zero projected onto the Q-value variable show an enhancement at Q-values of -60 - -80 MeV (excitation energies of the reaction partners equal to 30 - 40 MeV). This energy range coincides with the region of 2ℎω - 3ℎω excitations characteristic for giant osciallations. This selective excitation, which occurs at a very early stage of the reaction (the cross section is the largest at very forward angles), provides an important doorway to other dissipative processes

Production of carrier-free 28Mg and 24Na by 50-180 MeV protons on Si, P, S, Cl, Ar and K. Excitation functions and chemical separation

International Nuclear Information System (INIS)

Lundqvist, H.; Malmborg, P.

1976-01-01

This work investigates the possible use of high energy proton bomardment of silicon, phosphorous, sulphur, chlorine, argon or potassium for production of carrier-free 28 Mg. A chemical separation is essential in this preparation in order to get rid of the bulk of target material and contaminating radionuclides. A simple and efficient method to get carrier-free 28 Mg with neglectible amounts of radio-chemical impurities has been established. (Auth.)

The nematode homologue of Mediator complex subunit 28, F28F8.5, is a critical regulator of C. elegans development

Directory of Open Access Journals (Sweden)

Markéta Kostrouchová

2017-06-01

Full Text Available The evolutionarily conserved Mediator complex is a critical player in regulating transcription. Comprised of approximately two dozen proteins, the Mediator integrates diverse regulatory signals through direct protein-protein interactions that, in turn, modulate the influence of Mediator on RNA Polymerase II activity. One Mediator subunit, MED28, is known to interact with cytoplasmic structural proteins, providing a potential direct link between cytoplasmic dynamics and the control of gene transcription. Although identified in many animals and plants, MED28 is not present in yeast; no bona fide MED28 has been described previously in Caenorhabditis elegans. Here, we identify bioinformatically F28F8.5, an uncharacterized predicted protein, as the nematode homologue of MED28. As in other Metazoa, F28F8.5 has dual nuclear and cytoplasmic localization and plays critical roles in the regulation of development. F28F8.5 is a vital gene and its null mutants have severely malformed gonads and do not reproduce. F28F8.5 interacts on the protein level with the Mediator subunits MDT-6 and MDT-30. Our results indicate that F28F8.5 is an orthologue of MED28 and suggest that the potential to link cytoplasmic and nuclear events is conserved between MED28 vertebrate and nematode orthologues.

32 CFR 1605.28 - Signing official papers.

Science.gov (United States)

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Signing official papers. 1605.28 Section 1605.28 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM SELECTIVE SERVICE SYSTEM ORGANIZATION District Appeal Boards § 1605.28 Signing official papers. Official documents issued...

46 CFR 28.830 - Fire detection system.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Fire detection system. 28.830 Section 28.830 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY UNINSPECTED VESSELS REQUIREMENTS FOR COMMERCIAL FISHING INDUSTRY VESSELS Aleutian Trade Act Vessels § 28.830 Fire detection system. (a) Each accommodation space...

Gastroesophageal reflux: comparison of barium studies with 24-h pH monitoring

International Nuclear Information System (INIS)

Pan, John J.; Levine, Marc S.; Redfern, Regina O.; Rubesin, Stephen E.; Laufer, Igor; Katzka, David A.

2003-01-01

Objective: To determine the correlation between massive gastroesophageal reflux (GER) on barium studies and pathologic acid reflux on 24-h pH monitoring. Methods: A search of hospital records from January 1997 to January 2001 revealed 28 patients who underwent both barium studies and 24-h pH monitoring. The radiologic reports were reviewed to determine the presence and degree of GER. Patients with reflux to or above the thoracic inlet either spontaneously or with provocative maneuvers in the recumbent position were classified as having massive reflux, whereas the remaining patients with reflux below the thoracic inlet or no reflux comprised the control group. The pH monitoring reports were also reviewed to determine if pathologic acid reflux was present in the recumbent position. The findings on these studies were then compared to determine the frequency of pathologic acid reflux in the recumbent position on pH monitoring in patients with massive reflux on barium studies compared with the control group. Results: Massive GER was observed on barium studies in 11 (39%) of the 28 patients and reflux below the thoracic inlet or no reflux in the remaining 17 patients (61%) who comprised the control group. All 11 patients (100%) with massive reflux on barium studies had pathologic acid reflux on pH monitoring in the recumbent position compared with six (35%) of 17 patients in the control group (P=0.0009). The pH in the distal esophagus on pH monitoring was less than 4.0 for 13.1% of the recumbent period for patients with massive GER on barium studies compared with 6.2% of the recumbent period for the control group (P=0.0076). Conclusion: Although 24-h pH monitoring remains the gold standard for the detection of GER, our experience suggests that patients with massive reflux on barium studies are so likely to have pathologic acid reflux in the recumbent position that these individuals can be further evaluated and treated for their gastroesophageal reflux disease (GERD

Gastroesophageal reflux: comparison of barium studies with 24-h pH monitoring

Energy Technology Data Exchange (ETDEWEB)

Pan, John J.; Levine, Marc S. E-mail: levine@oasis.rad.upenn.edu; Redfern, Regina O.; Rubesin, Stephen E.; Laufer, Igor; Katzka, David A

2003-08-01

Objective: To determine the correlation between massive gastroesophageal reflux (GER) on barium studies and pathologic acid reflux on 24-h pH monitoring. Methods: A search of hospital records from January 1997 to January 2001 revealed 28 patients who underwent both barium studies and 24-h pH monitoring. The radiologic reports were reviewed to determine the presence and degree of GER. Patients with reflux to or above the thoracic inlet either spontaneously or with provocative maneuvers in the recumbent position were classified as having massive reflux, whereas the remaining patients with reflux below the thoracic inlet or no reflux comprised the control group. The pH monitoring reports were also reviewed to determine if pathologic acid reflux was present in the recumbent position. The findings on these studies were then compared to determine the frequency of pathologic acid reflux in the recumbent position on pH monitoring in patients with massive reflux on barium studies compared with the control group. Results: Massive GER was observed on barium studies in 11 (39%) of the 28 patients and reflux below the thoracic inlet or no reflux in the remaining 17 patients (61%) who comprised the control group. All 11 patients (100%) with massive reflux on barium studies had pathologic acid reflux on pH monitoring in the recumbent position compared with six (35%) of 17 patients in the control group (P=0.0009). The pH in the distal esophagus on pH monitoring was less than 4.0 for 13.1% of the recumbent period for patients with massive GER on barium studies compared with 6.2% of the recumbent period for the control group (P=0.0076). Conclusion: Although 24-h pH monitoring remains the gold standard for the detection of GER, our experience suggests that patients with massive reflux on barium studies are so likely to have pathologic acid reflux in the recumbent position that these individuals can be further evaluated and treated for their gastroesophageal reflux disease (GERD

7 CFR 2.28 - Chief Financial Officer.

Science.gov (United States)

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Chief Financial Officer. 2.28 Section 2.28 Agriculture....28 Chief Financial Officer. (a) The Chief Financial Officer, under the supervision of the Secretary, is responsible for executing the duties enumerated for agency Chief Financial Officers in the Chief...

46 CFR 28.325 - Fire detection systems.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Fire detection systems. 28.325 Section 28.325 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY UNINSPECTED VESSELS REQUIREMENTS FOR COMMERCIAL FISHING... Operate With More Than 16 Individuals on Board § 28.325 Fire detection systems. (a) Each accommodation...

6 CFR 5.28 - Preservation of records.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Preservation of records. 5.28 Section 5.28 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY DISCLOSURE OF RECORDS AND INFORMATION Privacy Act § 5.28 Preservation of records. Each component will preserve all correspondence...

GAC-EPA

CERN Document Server

GAC-EPA

2018-01-01

Le GAC organise des permanences avec entretiens individuels qui se tiennent le dernier mardi de chaque mois, sauf en juillet et décembre. La prochaine permanence se tiendra le : Mardi 29 mai de 13 h 30 à 16 h 00 Salle de réunion de l’Association du personnel Les permanences suivantes auront lieu les mardis 26 juin, 28 août, 25 septembre, 30 octobre et 27 novembre 2018. Les permanences du Groupement des Anciens sont ouvertes aux bénéficiaires de la Caisse de pensions (y compris les conjoints survivants) et à tous ceux qui approchent de la retraite. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association du personnel, les documents nécessaires. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association ...

GAC-EPA

CERN Document Server

GAC-EPA

2018-01-01

Le GAC organise des permanences avec entretiens individuels qui se tiennent le dernier mardi de chaque mois, sauf en juillet et décembre. La prochaine permanence se tiendra le : Mardi 26 juin de 13 h 30 à 16 h 00 Salle de réunion de l’Association du personnel Les permanences suivantes auront lieu les mardis 28 août, 25 septembre, 30 octobre et 27 novembre 2018. Les permanences du Groupement des Anciens sont ouvertes aux bénéficiaires de la Caisse de pensions (y compris les conjoints survivants) et à tous ceux qui approchent de la retraite. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association du personnel, les documents nécessaires. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association du perso...

GAC-EPA

CERN Multimedia

GAC-EPA

2017-01-01

Le GAC organise des permanences avec entretiens individuels qui se tiennent le dernier mardi de chaque mois, sauf en juin, juillet et décembre. La prochaine permanence se tiendra le : Mardi 25 avril de 13 h 30 à 16 h 00 Salle de réunion de l’Association du personnel Les permanences suivantes auront lieu les mardis 30 mai, 29 août, 26 septembre, 31 octobre et 28 novembre 2017. Les permanences du Groupement des Anciens sont ouvertes aux bénéficiaires de la Caisse de pensions (y compris les conjoints survivants) et à tous ceux qui approchent de la retraite. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association du personnel, les documents nécessaires. Informations : http://gac-epa.org/. Formulaire de contact : http://gac-epa.org/Organization/ContactForm/ContactForm-fr.php

GAC-EPA

CERN Multimedia

GAC-EPA

2018-01-01

Le GAC organise des permanences avec entretiens individuels qui se tiennent le dernier mardi de chaque mois, sauf en juillet et décembre. La prochaine permanence se tiendra le : Mardi 29 mai de 13 h 30 à 16 h 00 Salle de réunion de l’Association du personnel Les permanences suivantes auront lieu les mardis 26 juin, 28 août, 25 septembre, 30 octobre et 27 novembre 2018. Les permanences du Groupement des Anciens sont ouvertes aux bénéficiaires de la Caisse de pensions (y compris les conjoints survivants) et à tous ceux qui approchent de la retraite. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association du personnel, les documents nécessaires. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association...

GAC-EPA

CERN Multimedia

GAC-EPA

2018-01-01

Le GAC organise des permanences avec entretiens individuels qui se tiennent le dernier mardi de chaque mois, sauf en juillet et décembre. La prochaine permanence se tiendra le : Mardi 26 juin de 13 h 30 à 16 h 00 Salle de réunion de l’Association du personnel Les permanences suivantes auront lieu les mardis 28 août, 25 septembre, 30 octobre et 27 novembre 2018. Les permanences du Groupement des Anciens sont ouvertes aux bénéficiaires de la Caisse de pensions (y compris les conjoints survivants) et à tous ceux qui approchent de la retraite. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association du personnel, les documents nécessaires. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association du pers...

GAC-EPA

CERN Multimedia

GAC-EPA

2017-01-01

Le GAC organise des permanences avec entretiens individuels qui se tiennent le dernier mardi de chaque mois, sauf en juin, juillet et décembre. La prochaine permanence se tiendra le : Mardi 30 mai de 13 h 30 à 16 h 00 Salle de réunion de l’Association du personnel Les permanences suivantes auront lieu les mardis 29 août, 26 septembre, 31 octobre et 28 novembre 2017. Les permanences du Groupement des Anciens sont ouvertes aux bénéficiaires de la Caisse de pensions (y compris les conjoints survivants) et à tous ceux qui approchent de la retraite. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association du personnel, les documents nécessaires. Informations : http://gac-epa.org/. Formulaire de contact : http://gac-epa.org/Organization/ContactForm/ContactForm-fr.php

ORIENTEERING CLUB

CERN Multimedia

Club d'orientation

2013-01-01

Relais inter-club/Challenge Carlo Milan Samedi 28 septembre, à Apples-Ballens (Vd), a eu lieu le relais inter-club avec le Challenge Carlo Milan. 32 équipes étaient présentes pour défendre les couleurs de leur club, que se soit sur le relais technique avec trois coureurs ou sur le relais facile avec deux coureurs. La victoire du relais technique revenait à une équipe du CARE Vevey, quant au relais facile, la première place était pour le club Lausanne-Jorat. Le CO CERN avait à cœur de défendre le challenge Carlo Milan remporté l’an dernier mais il n’a pas pu résister au club du O’Jura, qui plaçait notamment quatre de ses équipes sur les six premières places du relais technique. Les rendez-vous de la coupe genevoise pour les deux prochaines semaines seront: - le vendredi 11 octobre aux Evaux pou...

45 CFR 99.28 - Record for decision.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Record for decision. 99.28 Section 99.28 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROCEDURE FOR HEARINGS FOR THE CHILD CARE AND DEVELOPMENT FUND Hearing Procedures § 99.28 Record for decision. The transcript of...

29 CFR 783.28 - General legislative history.

Science.gov (United States)

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false General legislative history. 783.28 Section 783.28 Labor... TO EMPLOYEES EMPLOYED AS SEAMEN Legislative History and Judicial Construction of the Exemptions § 783.28 General legislative history. As originally enacted in 1938, section 13(a)(3) of the Fair Labor...

: tous les projets | Page 470 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Date de début : 5 septembre 2007. End Date: 23 janvier 2010. Sujet: COMMUNITY FACILITIES, INFORMATION CENTRES, INFORMATION TECHNOLOGY, COMPUTERS, Internet. Région: Bangladesh, Central Asia, Far East Asia, South Asia, India, Malaysia, Nepal, Viet Nam, Thailand. Financement total : CA$ 137,926.00.

Rbm24a and Rbm24b are required for normal somitogenesis.

Directory of Open Access Journals (Sweden)

Samantha Maragh

Full Text Available We recently demonstrated that the gene encoding the RNA binding motif protein 24 (RBM24 is expressed during mouse cardiogenesis, and determined the developmental requirement for its zebrafish homologs Rbm24a and Rbm24b during cardiac development. We demonstrate here that both Rbm24a and Rbm24b are also required for normal somite and craniofacial development. Diminution of rbm24a or rbm24b gene products by morpholino knockdown resulted in significant disruption of somite formation. Detailed in situ hybridization-based analyses of a spectrum of somitogenesis-associated transcripts revealed reduced expression of the cyclic muscle pattering genes dlc and dld encoding Notch ligands, as well as their respective target genes her7, her1. By contrast expression of the Notch receptors notch1a and notch3 appears unchanged. Some RBM-family members have been implicated in pre-mRNA processing. Analysis of affected Notch-pathway mRNAs in rbm24a and rbm24b morpholino-injected embryos revealed aberrant transcript fragments of dlc and dld, but not her1 or her7, suggesting the reduction in transcription levels of Notch pathway components may result from aberrant processing of its ligands. These data imply a previously unknown requirement for Rbm24a and Rbm24b in somite and craniofacial development. Although we anticipate the influence of disrupting RBM24 homologs likely extends beyond the Notch pathway, our results suggest their perturbation may directly, or indirectly, compromise post-transcriptional processing, exemplified by imprecise processing of dlc and dld.

7 CFR 28.432 - Middling Tinged Color.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Middling Tinged Color. 28.432 Section 28.432... REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Standards Tinged Cotton § 28.432 Middling Tinged Color. Middling Tinged Color is color which is within the range represented by a set of samples in the custody of...

7 CFR 28.423 - Middling Spotted Color.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Middling Spotted Color. 28.423 Section 28.423... REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Standards Spotted Cotton § 28.423 Middling Spotted Color. Middling Spotted Color is color which is within the range represented by a set of samples in the custody of...

7 CFR 28.301 - Measurement: humidity; temperature.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Measurement: humidity; temperature. 28.301 Section 28... for Length of Staple § 28.301 Measurement: humidity; temperature. The length of staple of any cotton... its fibers under a relative humidity of the atmosphere of 65 percent and a temperature of 70° F. ...

28 CFR 97.24 - No civil defense created.

Science.gov (United States)

2010-07-01

... intended to and does not establish a defense against an allegation of negligence or breach of contract..., statutory, and common law upon their activities (or other activities of a similarly hazardous nature). ...

28 CFR 66.24 - Matching or cost sharing.

Science.gov (United States)

2010-07-01

... donated. (f) Valuation of grantee or subgrantee donated real property for construction/acquisition. If a... described in § 66.25(g).) (5) Services or property financed by income earned by contractors. Contractors... amounts earned from the party awarding the contract. No costs of services or property supported by this...

28 CFR 50.24 - Annuity broker minimum qualifications.

Science.gov (United States)

2010-07-01

... providing annuity brokerage services in connection with structured settlements entered by the United States... insurance company to sell its structured settlement annuity contracts or to act as a structured settlement... substantial experience in each of the past three years in providing structured settlement brokerage services...

β-delayed proton decay of 28S

International Nuclear Information System (INIS)

Pougheon, F.; Borrel, V.; Jacmart, J.C.; Bazin, D.; Del Moral, R.; Dufour, J.P.; Hubert, F.; Pravikoff, M.S.; Brown, B.A.

1989-01-01

β-delayed proton radioactivity has been observed for the 28 S isotope (T x = -2), produced by projectile fragmentation of 85 MeV/u 36 Ar. The measured half-life of 28 S is 125 ± 10 ms. Energy spectra of β-delayed protons have been measured. The lowest T = 2 state in the daughter nucleus 28 P has been located at an excitation energy of 5900 ± 21 keV. A comparison of the experimental data to the quadratic form of the isobaric multiplet mass equation shows that the energies of the five T = 2 states of the A = 28 quintet are well represented by that relation. Shell-model predictions for the half-life, location and decay properties of the lowest T = 2 state of 28 P are in good agreement with experimental data

7 CFR 15b.28 - Private education.

Science.gov (United States)

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Private education. 15b.28 Section 15b.28 Agriculture... Education § 15b.28 Private education. (a) A recipient that provides private elementary or secondary education may not, on the basis of handicap, exclude a qualified handicapped person if the person can, with...

7 CFR 28.405 - Low Middling Color.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Low Middling Color. 28.405 Section 28.405 Agriculture..., TESTING, AND STANDARDS Standards Official Cotton Standards of the United States for the Color Grade of American Upland Cotton § 28.405 Low Middling Color. Low Middling Color is color which is within the range...

7 CFR 28.407 - Good Ordinary Color.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Good Ordinary Color. 28.407 Section 28.407 Agriculture..., TESTING, AND STANDARDS Standards Official Cotton Standards of the United States for the Color Grade of American Upland Cotton § 28.407 Good Ordinary Color. Good Ordinary Color is color which is within the range...

7 CFR 28.402 - Strict Middling Color.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Strict Middling Color. 28.402 Section 28.402... for the Color Grade of American Upland Cotton § 28.402 Strict Middling Color. Strict Middling Color is color which is within the range represented by a set of samples in the custody of the United States...

7 CFR 28.401 - Good Middling Color.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Good Middling Color. 28.401 Section 28.401 Agriculture..., TESTING, AND STANDARDS Standards Official Cotton Standards of the United States for the Color Grade of American Upland Cotton § 28.401 Good Middling Color. Good Middling Color is color which is within the range...

12 CFR 563e.28 - Assigned ratings.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Assigned ratings. 563e.28 Section 563e.28 Banks... for Assessing Performance § 563e.28 Assigned ratings. (a) Ratings in general. Subject to paragraphs (b... performance under the lending, investment and service tests, the community development test, the small savings...

46 CFR 28.130 - Survival craft equipment.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Survival craft equipment. 28.130 Section 28.130 Shipping... INDUSTRY VESSELS Requirements for All Vessels § 28.130 Survival craft equipment. (a) General. Each item of survival craft equipment must be of good quality, effective for the purpose it is intended to serve, and...

24(S)-Saringosterol from edible marine seaweed Sargassum fusiforme is a novel selective LXRβ agonist.

Science.gov (United States)

Chen, Zhen; Liu, Jiao; Fu, Zhifei; Ye, Cheng; Zhang, Renshuai; Song, Yiyun; Zhang, Ying; Li, Haihua; Ying, Hao; Liu, Hongbing

2014-07-02

Dietary phytosterols have been successfully used for lowering cholesterol levels, which correlates with the fact that some phytosterols are able to act as liver X receptor (LXR) agonists. Sargassum fusiforme is an edible marine seaweed well-known for its antiatherosclerotic function in traditional Chinese medicine. In this study, seven phytosterols including fucosterol (1), saringosterol (2), 24-hydroperoxy-24-vinyl-cholesterol (3), 29-hydroperoxy-stigmasta-5,24(28)-dien-3β-ol (4), 24-methylene-cholesterol (5), 24-keto-cholesterol (6), and 5α,8α-epidioxyergosta-6,22-dien-3β-ol (7) were purified and evaluated for their actions on LXR-mediated transcription using a reporter assay. Among these phytosterols, 2 was the most potent compound in stimulating the transcriptional activities of LXRα by (3.81±0.15)-fold and LXRβ by (14.40±1.10)-fold, respectively. Two epimers of 2, 24(S)-saringosterol (2a) and 24(R)-saringosterol (2b), were subsequently separated by semipreparative high-performance liquid chromatography. Interestingly, 2a was more potent than 2b in LXRβ-mediated transactivation ((3.50±0.17)-fold vs (1.63±0.12)-fold) compared with control. Consistently, 2a induced higher expression levels of LXR target genes including key players in reverse cholesterol transport in six cell lines. These data along with molecular modeling suggested that 2a acts as a selective LXRβ agonist and is a potent natural cholesterol-lowering agent. This study also demonstrated that phytosterols in S. fusiforme contributed to the well-known antiatherosclerotic function.

12 CFR 28.21 - Service of process.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Service of process. 28.21 Section 28.21 Banks... Federal Branches and Agencies of Foreign Banks § 28.21 Service of process. A foreign bank operating at any Federal branch or agency is subject to service of process at the location of the Federal branch or agency. ...

46 CFR 28.250 - High water alarms.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false High water alarms. 28.250 Section 28.250 Shipping COAST... Individuals On Board, or for Fish Tender Vessels Engaged in the Aleutian Trade § 28.250 High water alarms. On... operating station to indicate high water level in each of the following normally unmanned spaces: (a) A...

A new oxomolybdate component extracted from the "virtual dynamic library" yielding the macrocyclic anion [(Mo(VI)(8)O(28))(4)(Mo(V)(2)O(2)S(2))(4)](24-).

Science.gov (United States)

Korenev, Vladimir S; Boulay, Antoine G; Dolbecq, Anne; Sokolov, Maxim N; Hijazi, Akram; Floquet, Sébastien; Fedin, Vladimir P; Cadot, Emmanuel

2010-11-01

A rare isomer of the {Mo(8)O(28)}(8-) anion has been trapped from an acidified aqueous solution of molybdate by using the {Mo(2)O(2)S(2)}(2+) oxothio cation as the linker and isolated as a part of a unique macrocyclic anion, which consists of four isopolyoxomolybdate fragments {Mo(8)O(28)} bridged by four {Mo(2)O(2)S(2)} units.

CD28 Aptamers as Powerful Immune Response Modulators

Directory of Open Access Journals (Sweden)

Fernando Pastor

2013-01-01

Full Text Available CD28 is one of the main costimulatory receptors responsible for the proper activation of T lymphocytes. We have isolated two aptamers that bind to the CD28 receptor. As a monomer, one of them interfered with the binding of CD28 to its ligand (B7, precluding the costimulatory signal, whereas the other one was inactive. However, dimerization of any of the anti-CD28 aptamers was sufficient to provide an artificial costimulatory signal. No antibody has featured a dual function (i.e., the ability to work as agonist and antagonist to date. Two different agonistic structures were engineered for each anti-CD28 aptamer. One showed remarkably improved costimulatory properties, surpassing the agonistic effect of an anti-CD28 antibody. Moreover, we showed in vivo that the CD28 agonistic aptamer is capable of enhancing the cellular immune response against a lymphoma idiotype and of prolonging survival of mice which receive the aptamer together with an idiotype vaccine. The CD28 aptamers described in this work could be used to modulate the immune response either blocking the interaction with B7 or enhancing vaccine-induced immune responses in cancer immunotherapy.

Le CRDI contribue à la conversation sur la transformation agricole ...

International Development Research Centre (IDRC) Digital Library (Canada)

3 oct. 2016 ... La recherche et les partenariats du CRDI étaient à l'honneur au Forum de la révolution verte en Afrique de cette année, qui s'est déroulé du 5 au 9 septembre à Nairobi, au Kenya.

: tous les projets | Page 118 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

, la libéralisation du commerce a entraîné une hausse importante de la consommation de tabac chez les femmes et les enfants de certains pays d'Asie. Date de début : 21 janvier 2014. End Date: 30 septembre 2015. Sujet: SOUTHEAST ASIA ...

india : tous les projets | Page 8 | CRDI - Centre de recherches pour ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le nombre d'enfants aux prises avec des difficultés mentales est important et augmente à un rythme alarmant en Inde. Date de début : 23 septembre 2011. End Date: 29 octobre 2012. Sujet: MENTAL DISEASES, MENTALLY DISABLED, CHILDREN, INFORMATION TECHNOLOGY, COMPUTERS, COMPUTER PROGRAMS.

: tous les projets | Page 249 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le nombre d'enfants aux prises avec des difficultés mentales est important et augmente à un rythme alarmant en Inde. Date de début : 23 septembre 2011. End Date: 29 octobre 2012. Sujet: MENTAL DISEASES, MENTALLY DISABLED, CHILDREN, INFORMATION TECHNOLOGY, COMPUTERS, COMPUTER PROGRAMS.

: tous les projets | Page 250 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le nombre d'enfants aux prises avec des difficultés mentales est important et augmente à un rythme alarmant en Inde. Date de début : 23 septembre 2011. End Date: 29 octobre 2012. Sujet: MENTAL DISEASES, MENTALLY DISABLED, CHILDREN, INFORMATION TECHNOLOGY, COMPUTERS, COMPUTER PROGRAMS.

Residual adrenal function in autoimmune Addison's disease: improvement after tetracosactide (ACTH1-24) treatment.

Science.gov (United States)

Gan, Earn H; MacArthur, Katie; Mitchell, Anna L; Hughes, Beverly A; Perros, Petros; Ball, Stephen G; James, R Andrew; Quinton, Richard; Chen, Shu; Furmaniak, Jadwiga; Arlt, Wiebke; Pearce, Simon H S

2014-01-01

Despite lifelong steroid hormone replacement, there is excess morbidity and mortality associated with autoimmune Addison's disease. In health, adrenocortical cells undergo continuous self-renewal from a population of subcapsular progenitor cells, under the influence of ACTH, suggesting a therapeutic possibility. We aimed to determine whether tetracosactide (synthetic ACTH1-24) could revive adrenal steroidogenic function in autoimmune Addison's disease. Thirteen patients (aged 16-65 y) with established autoimmune Addison's disease for more than 1 year were recruited at the Newcastle University Clinical Research Facility. The intervention included a 20-week study of regular sc tetracosactide (ACTH1-24) therapy. Serum and urine corticosteroids were measured during medication withdrawal at baseline and every 5 weeks during the study. Serum cortisol levels remained less than 100 nmol/L in 11 of 13 participants throughout the study. However, two women achieved peak serum cortisol concentrations greater than 400 nmol/L after 10 and 29 weeks of tetracosactide therapy, respectively, allowing withdrawal of corticosteroid replacement. Concurrently, urine glucocorticoid and mineralocorticoid metabolite excretion increased from subnormal to above the median of healthy controls. One of these responders remains well with improving peak serum cortisol (672 nmol/L) 28 months after stopping all treatments. The other responder showed a gradual reduction in serum cortisol and aldosterone over time, and steroid therapy was recommenced after a 28-week period without glucocorticoid replacement. This is the first study to demonstrate that established autoimmune Addison's disease is amenable to a regenerative medicine therapy approach.

28 CFR 91.53 - Other guidance.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Other guidance. 91.53 Section 91.53 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) GRANTS FOR CORRECTIONAL FACILITIES Environmental... Justice has also published NEPA procedures that incorporate the CEQ regulations at 28 CFR part 61...

10 CFR 850.28 - Respiratory protection.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Respiratory protection. 850.28 Section 850.28 Energy... Respiratory protection. (a) The responsible employer must establish a respiratory protection program that complies with the respiratory protection program requirements of 29 CFR 1910.134, Respiratory Protection...

Will Solar Cycles 25 and 26 Be Weaker than Cycle 24?

Science.gov (United States)

Javaraiah, J.

2017-11-01

The study of variations in solar activity is important for understanding the underlying mechanism of solar activity and for predicting the level of activity in view of the activity impact on space weather and global climate. Here we have used the amplitudes (the peak values of the 13-month smoothed international sunspot number) of Solar Cycles 1 - 24 to predict the relative amplitudes of the solar cycles during the rising phase of the upcoming Gleissberg cycle. We fitted a cosine function to the amplitudes and times of the solar cycles after subtracting a linear fit of the amplitudes. The best cosine fit shows overall properties (periods, maxima, minima, etc.) of Gleissberg cycles, but with large uncertainties. We obtain a pattern of the rising phase of the upcoming Gleissberg cycle, but there is considerable ambiguity. Using the epochs of violations of the Gnevyshev-Ohl rule (G-O rule) and the `tentative inverse G-O rule' of solar cycles during the period 1610 - 2015, and also using the epochs where the orbital angular momentum of the Sun is steeply decreased during the period 1600 - 2099, we infer that Solar Cycle 25 will be weaker than Cycle 24. Cycles 25 and 26 will have almost same strength, and their epochs are at the minimum between the current and upcoming Gleissberg cycles. In addition, Cycle 27 is expected to be stronger than Cycle 26 and weaker than Cycle 28, and Cycle 29 is expected to be stronger than both Cycles 28 and 30. The maximum of Cycle 29 is expected to represent the next Gleissberg maximum. Our analysis also suggests a much lower value (30 - 40) for the maximum amplitude of the upcoming Cycle 25.

Perception de la chimioprévention du paludisme saisonnier au ...

African Journals Online (AJOL)

3 Centre de Recherche Médicale et Sanitaire de Niamey, Niger. 4 Direction de la Surveillance et de la Riposte aux .... d'enfants en raison de. 40 enfants par CSI. La collecte des données a été faite à l'aide de questionnaire aux mères des enfants de 3 à 59 mois. Les outils de collecte sont constitués par des questionnaires.

Induction therapy with adalimumab plus methotrexate for 24 weeks followed by methotrexate monotherapy up to week 48 versus methotrexate therapy alone for DMARD-naive patients with early rheumatoid arthritis: HIT HARD, an investigator-initiated study.

Science.gov (United States)

Detert, Jacqueline; Bastian, Hans; Listing, Joachim; Weiß, Anja; Wassenberg, Siegfried; Liebhaber, Anke; Rockwitz, Karin; Alten, Rieke; Krüger, Klaus; Rau, Rolf; Simon, Christina; Gremmelsbacher, Eva; Braun, Tanja; Marsmann, Bettina; Höhne-Zimmer, Vera; Egerer, Karl; Buttgereit, Frank; Burmester, Gerd-R

2013-06-01

To investigate the long-term effects of induction therapy with adalimumab (ADA) plus methotrexate (MTX) in comparison with placebo (PBO) plus MTX in DMARD-naïve patients with active early rheumatoid arthritis (RA). Patients with active early RA (disease duration of ≤12 months) were randomly assigned to receive 40 mg ADA subcutaneously every other week (eow) plus MTX 15 mg/week subcutaneously or PBO plus MTX subcutaneously at 15 mg/week over 24 weeks. Thereafter, all patients received MTX monotherapy up to week 48. The primary outcome was the Disease Activity Score 28 (DAS28) at week 48. Secondary outcomes included proportions of patients in remission (DAS28Health Assessment Questionnaire (HAQ) score and radiographic progression. 87 patients were assigned to ADA/MTX and 85 patients to PBO/MTX. At baseline, DAS28 was 6.2±0.8 in the ADA/MTX and 6.3±0.9 in the PBO/MTX groups. At week 24, treatment with ADA/MTX compared with PBO/MTX resulted in a greater reduction in DAS28 (3.0±1.2 vs 3.6±1.4; p=0.009) and other secondary outcomes such as DAS28 remission rate (47.9% vs 29.5%; p=0.021) and HAQ (0.49±0.6 vs 0.72±0.6; p=0.0014). At week 48, the difference in clinical outcomes between groups was not statistically significant (DAS28: 3.2±1.4 vs 3.4±1.6; p=0.41). Radiographic progression at week 48 was significantly greater in patients administered PBO/MTX (Sharp/van der Heijde score: ADA/MTX 2.6 vs PBO/MTX 6.4; p=0.03, Ratingen score: 1.7 vs 4.2; p=0.01). A greater reduction in radiographic progression after initial combination therapy with ADA and MTX was seen at week 48, even after discontinuation of ADA treatment at week 24. This sustained effect was not found at the primary endpoint (DAS28 reduction).

The Text of the Agreement of 28 July 1975 between Swaziland and the Agency for the Application of Safeguards in Connection with the Treaty on the Non-Proliferation of Nuclear Weapons

Energy Technology Data Exchange (ETDEWEB)

NONE

1975-12-18

The text of the Agreement of 28 July 1975, and of the Protocol thereto, between Swaziland and the Agency for the application of safeguards in connection with the Treaty on the Non-Proliferation of Nuclear Weapons is reproduced in this document for the information of all Members. The Agreement entered into force on 28 July 1975, pursuant to Article 24 thereof. The Protocol entered into force on the same date, pursuant to Article III thereof.

14 CFR 129.28 - Flightdeck security.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Flightdeck security. 129.28 Section 129.28... Flightdeck security. (a) After August 20, 2002, except for a newly manufactured airplane on a non-revenue...; or the operator must implement a security program approved by the Transportation Security...

Transforming Gender and Food Security in the Global South | CRDI ...

International Development Research Centre (IDRC) Digital Library (Canada)

Transforming Gender and Food Security in the Global South. Page couverture du livre: Transforming Gender and Food Security in the Global South. Directeur(s):. Jemimah Njuki, John R. Parkins et Amy Kaler. Maison(s) d'édition: Routledge, CRDI. 29 septembre 2016. ISBN : 9781138680418. 312 pages. e-ISBN :.

: tous les projets | Page 402 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Les déplacements quotidiens de millions de personnes vers leur lieu de travail constituent une importante source de pollution en milieu urbain. Date de début : 1 mars 2010. End Date: 1 septembre 2012. Sujet: WORKING CONDITIONS, ENERGY CONSUMPTION, INFORMATION TECHNOLOGY. Région: Argentina, South ...

20 CFR 617.28 - Transportation payments.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Transportation payments. 617.28 Section 617... ASSISTANCE FOR WORKERS UNDER THE TRADE ACT OF 1974 Reemployment Services § 617.28 Transportation payments. (a... transportation expenses if the training is outside the commuting area, but may not receive such assistance if...

21 CFR 181.28 - Release agents.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Release agents. 181.28 Section 181.28 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... Release agents. Substances classified as release agents, when migrating from food-packaging material shall...

Cycloartane-3,24,25-triol inhibits MRCKα kinase and demonstrates promising anti prostate cancer activity in vitro.

Science.gov (United States)

Lowe, Henry I C; Watson, Charah T; Badal, Simone; Toyang, Ngeh J; Bryant, Joseph

2012-11-14

Given the high occurrence of prostate cancer worldwide and one of the major sources of the discovery of new lead molecules being medicinal plants, this research undertook to investigate the possible anti-cancer activity of two natural cycloartanes; cycloartane-3,24,25-diol (extracted in our lab from Tillandsia recurvata) and cycloartane-3,24,25-triol (purchased). The inhibition of MRCKα kinase has emerged as a potential solution to restoring the tight regulation of normal cellular growth, the loss of which leads to cancer cell formation. Kinase inhibition was investigated using competition binding (to the ATP sites) assays which have been previously established and authenticated and cell proliferation was measured using the WST-1 assay. Cycloartane-3,24,25-triol demonstrated strong selectivity towards the MRCKα kinase with a Kd50 of 0.26 μM from a total of 451 kinases investigated. Cycloartane-3,24,25-triol reduced the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively. These results will prove useful in drug discovery as Cycloartane-3,24,25-triol has shown potential for development as an anti-cancer agent against prostate cancer.

Recombination channels in 2.4–3.2 µm GaInAsSb quantum-well lasers

International Nuclear Information System (INIS)

Gadedjisso-Tossou, K S; Belahsene, S; Tournié, E; Rouillard, Y; Mohou, M A

2013-01-01

Spontaneous emission has been used to evaluate the proportion of the different recombination channels in 2.4–3.2 µm type I- GaInAsSb quantum-well lasers operating at room temperature. The method consists in using the square root of the integrated spontaneous emission rate as a value proportional to the carrier density. A second-degree polynomial relationship can then be used to determine the proportion of the different recombination currents (monomolecular, radiative and Auger) in a laser diode operated below threshold. A notable increase of the Auger recombination has been observed with increasing wavelength. Auger recombination currents account for only 26% of the total current at threshold at 2.4 µm, while the proportion reaches 55% at 2.8 µm and 64% at 3.2 µm. (paper)

February 28, 2009

Indian Academy of Sciences (India)

2009-02-28

Feb 28, 2009 ... http://www.loksatta.com/daily/20090228/ch04.htm. #3. Expressindia | T he Indian Express| The Financial Express City Newslines | Screen | Kashmir Live ||. Express Computer. | Network Mag az ine Indja eBusiness TravelleexpressP harmal Express Hospitality| Express T extile|. Express TravelWorld.

17 CFR 171.28 - Participation by Commission staff.

Science.gov (United States)

2010-04-01

... staff. 171.28 Section 171.28 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION..., Membership Denial and Registration Actions § 171.28 Participation by Commission staff. The Division of.... The Commission shall by order establish a supplementary briefing schedule for the Commission staff and...

40 CFR 430.28 - Best management practices (BMPs).

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Best management practices (BMPs). 430.28 Section 430.28 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT... Soda Subcategory § 430.28 Best management practices (BMPs). The definitions and requirements set forth...

Therapeutic Applications of Interleukin 24 (IL24): A Review ...

African Journals Online (AJOL)

IL24 has growth suppressive properties in a wide variety of human cancer cell lines without inducing harmful effects in normal cells. This review is focused on the role of IL 24 on tumor cell biology and its potential therapeutic applications. Keywords: Melanoma differentiation, Protein, Therapeutics, Interleukin, ...

31 CFR 28.410 - Comparable facilities.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Comparable facilities. 28.410 Section... on the Basis of Sex in Education Programs or Activities Prohibited § 28.410 Comparable facilities. A recipient may provide separate toilet, locker room, and shower facilities on the basis of sex, but such...

AGOR 28

Science.gov (United States)

2015-12-18

and transporting them to a vendor in Seattle for measurements . The measuring will take place between the 28th and 30th. • Steering Hydraulics...the suction lower down on the hull. • CTD Handling Device – The cylinder has been reinstalled and tested. The repaired sensor is now measuring rod...Communications – FCC Station license applied for and approved. FBB activated. Iridium SIM Card in route from service provider. Inmarsat C’s and

Energy situation september 2002; Conjoncture energetique septembre 2002

Energy Technology Data Exchange (ETDEWEB)

NONE

2002-10-01

The monthly situation analysis in France is presented. Statistics are given for energy consumption, demand, import and export. A special attention is given to the primary energy, the solid fuels, the petroleum products, the natural gas and the electric power. (A.L.B.)

Energy situation - September 2007; Conjoncture energetique - septembre 2007

Energy Technology Data Exchange (ETDEWEB)

NONE

2007-10-15

This report makes a status of the French energy expenses, prices, production, consumption, demand, import and export since January 2005 and up to August 2007. Details are given separately for primary energy, solid mineral fuels, petroleum products, natural gas and electric power. (J.S.)

Energy situation september 2005; Conjoncture energetique septembre 2005

Energy Technology Data Exchange (ETDEWEB)

NONE

2005-10-15

The monthly energy situation analysis in France at september 2005, is presented. Statistics are given for energy consumption, demand, import and export. A special attention is given to the primary energy, the solid fuels, the petroleum products, the natural gas and the electric power. (A.L.B.)

Incidence of DCS and oxygen toxicity in chamber attendants: a 28-year experience.

Science.gov (United States)

Witucki, Pete; Duchnick, Jay; Neuman, Tom; Grover, Ian

2013-01-01

Decompression sickness (DCS) and central nervous system oxygen toxicity are inherent risks for "inside" attendants (IAs) of hyperbaric chambers. At the Hyperbaric Medicine Center at the University of California San Diego (UCSD), protocols have been developed for decompressing IAs. Protocol 1: For a total bottom time (TBT) of less than 80 minutes at 2.4 atmospheres absolute (atm abs) or shallower, the U.S. Navy (1955) no-decompression tables were utilized. Protocol 2: For a TBT between 80 and 119 minutes IAs breathed oxygen for 15 minutes prior to initiation of ascent. Protocol 3: For a TBT between 120-139 minutes IAs breathed oxygen for 30 minutes prior to ascent. These protocols have been utilized for approximately 28 years and have produced zero cases of DCS and central nervous system oxygen toxicity. These results, based upon more than 24,000 exposures, have an upper limit of risk of DCS and oxygen toxicity of 0.02806 (95% CI) using UCSD IA decompression Protocol 1, 0.00021 for Protocol 2, and 0.00549 for Protocol 3. We conclude that the utilization of this methodology may be useful at other sea-level multiplace chambers.

Dose evaluation on the basis of {sup 24}Na activity in the human body for the criticality accident at JCO Tokai nuclear fuel processing plant

Energy Technology Data Exchange (ETDEWEB)

Momose, T.; Tsujimura, N.; Tasaki, T.; Kanai, K.; Hayashi, N.; Shinohara, K. [Japan Nuclear Cycle Development Inst., Tokai, Ibaraki (Japan)

2000-07-01

Sodium-24({sup 24}Na) generated in human body due to neutron activation was measured by whole body counter (WBC) in JNC Tokai works. Total 148 persons (JCO employees and contractor, public member, fire fighters, etc.) were measured and {sup 24}Na was detected in the 62 persons. Neutron energy spectrum around the facility was calculated using ANISN and MCNP code and estimated mean capture probability {xi} of neutron for human body at this accident was around 0.25-0.28 at any distance from the center of the precipitation tank. Effective dose equivalent for the 62 persons were estimated based on the calculated conversion factors from {sup 24}Na specific activity to neutron dose. Maximum {sup 24}Na activity was 7.7 kBq (83 Bq({sup 24}Na)/g({sup 23}Na)) in total body and the evaluated effective dose equivalent was 47 mSv. (author)

The Constitutional Review Chamber of the Republic of Estonia judgment : no. of the case 3-4-1-10-02 : date of decision 24 December 2002

Index Scriptorium Estoniae

2003-01-01

Riigikohtu lahendi 3-4-1-10-02 (Tallinna Halduskohtu taotlus kontrollida rahandusministri 28. 01. 2002 määruse nr. 24 "Ametiisikute palgaandmete avalikustamise kord ja tingimused" ning palgaseaduse § 8 lg 3.1 viimase lause vastavust põhiseadusele) tekst inglise keeles

49 CFR 28.150 - Program accessibility: Existing facilities.

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Program accessibility: Existing facilities. 28.150 Section 28.150 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION § 28...

44 CFR 351.28 - The Department of Commerce.

Science.gov (United States)

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false The Department of Commerce. 351.28 Section 351.28 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY... Assignments § 351.28 The Department of Commerce. (a) Assist State and local governments in determining their...

48 CFR 31.205-28 - Other business expenses.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Other business expenses. 31.205-28 Section 31.205-28 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... Organizations 31.205-28 Other business expenses. The following types of recurring costs are allowable (a...

24 CFR 203.369 - Deficiency judgments.

Science.gov (United States)

2010-04-01

... commitments issued on or after March 28, 1988, or pursuant to direct endorsement processing where the credit... insured pursuant to firm commitments issued before March 28, 1988, or pursuant to direct endorsement processing where the credit worksheet was signed by the mortgagee's underwriter before March 28, 1988, the...

27 CFR 28.230 - Consignment, shipment, and delivery.

Science.gov (United States)

2010-04-01

... delivery. 28.230 Section 28.230 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Drawback Consignment, Shipment, and Delivery § 28.230 Consignment, shipment, and delivery. The consignment, shipment, and delivery of taxpaid beer removed under this subpart shall be made under the provisions of...

27 CFR 28.106 - Consignment, shipment, and delivery.

Science.gov (United States)

2010-04-01

... delivery. 28.106 Section 28.106 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Transportation to a Manufacturing Bonded Warehouse § 28.106 Consignment, shipment, and delivery. The consignment, shipment, and delivery of distilled spirits withdrawn without payment of tax under this subpart shall be...

27 CFR 28.196 - Consignment, shipment, and delivery.

Science.gov (United States)

2010-04-01

... delivery. 28.196 Section 28.196 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Benefit of Drawback Filing of Notice and Removal § 28.196 Consignment, shipment, and delivery. The consignment, shipment, and delivery of distilled spirits removed under this subpart for export, use on vessels...

31 CFR 28.630 - Judicial review.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Judicial review. 28.630 Section 28.630 Money and Finance: Treasury Office of the Secretary of the Treasury NONDISCRIMINATION ON THE BASIS... Judicial review. Action taken pursuant to 20 U.S.C. 1682 is subject to judicial review as provided in 20 U...

27 CFR 28.193 - Export marks.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.193... Drawback Filing of Notice and Removal § 28.193 Export marks. In addition to the marks and brands required... chapter, the exporter shall mark the word “Export” on the Government side of each case or Government head...

27 CFR 28.103 - Export marks.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.103... Manufacturing Bonded Warehouse § 28.103 Export marks. (a) General. In addition to the marks and brands required... provisions of part 19 of this chapter, the proprietor shall mark the word “Export” on the Government side of...

27 CFR 28.144 - Export marks.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.144... § 28.144 Export marks. (a) General Requirement. In addition to the marks and brands required to be... brewer shall mark the word “Export” on each container or case of beer, or the words “Beer concentrate for...

27 CFR 28.154 - Export marks.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.154..., for Exportation or Transfer to a Foreign-Trade Zone § 28.154 Export marks. In addition to the marks... provisions of part 19 of this chapter, the proprietor shall mark the word “Export” on the Government side of...

24 Hours of Sleep, Sedentary Behavior, and Physical Activity with Nine Wearable Devices

Science.gov (United States)

Rosenberger, Mary E.; Buman, Matthew P.; Haskell, William L.; McConnell, Michael V.; Carstensen, Laura L.

2015-01-01

Getting enough sleep, exercising and limiting sedentary activities can greatly contribute to disease prevention and overall health and longevity. Measuring the full 24-hour activity cycle - sleep, sedentary behavior (SED), light intensity physical activity (LPA) and moderate-to-vigorous physical activity (MVPA) - may now be feasible using small wearable devices. PURPOSE This study compares nine devices for accuracy in 24-hour activity measurement. METHODS Adults (N=40, 47% male) wore nine devices for 24-hours: Actigraph GT3X+, activPAL, Fitbit One, GENEactiv, Jawbone Up, LUMOback, Nike Fuelband, Omron pedometer, and Z-Machine. Comparisons (to standards) were made for total sleep time (Z-machine), time spent in SED (activPAL), LPA (GT3x+), MVPA (GT3x+), and steps (Omron). Analysis included mean absolute percent error, equivalence testing, and Bland-Altman plots. RESULTS Error rates ranged from 8.1–16.9% for sleep; 9.5–65.8% for SED; 19.7–28.0% for LPA; 51.8–92% for MVPA; and 14.1–29.9% for steps. Equivalence testing indicated only two comparisons were significantly equivalent to standards: the LUMOback for sedentary behavior and the GT3X+ for sleep. Bland-Altman plots indicated GT3X+ had the closest measurement for sleep, LUMOback for sedentary behavior, GENEactiv for LPA, Fitbit for MVPA and GT3X+ for steps. CONCLUSIONS Currently, no device accurately captures activity data across the entire 24-hour day, but the future of activity measurement should aim for accurate 24-hour measurement as a goal. Researchers should continue to select measurement devices based on their primary outcomes of interest. PMID:26484953

46 CFR 28.125 - Stowage of survival craft.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Stowage of survival craft. 28.125 Section 28.125... FISHING INDUSTRY VESSELS Requirements for All Vessels § 28.125 Stowage of survival craft. (a) Each..., inflatable buoyant apparatus, and any auxiliary craft used in their place, must be kept readily accessible...

41 CFR 109-28.000-51 - Storage guidelines.

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Storage guidelines. 109-28.000-51 Section 109-28.000-51 Public Contracts and Property Management Federal Property Management...-STORAGE AND DISTRIBUTION § 109-28.000-51 Storage guidelines. (a) Indoor storage areas should be arranged...

27 CFR 28.145 - Consignment, shipment and delivery.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Consignment, shipment and delivery. 28.145 Section 28.145 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE...-Trade Zone § 28.145 Consignment, shipment and delivery. The consignment, shipment and delivery of beer...

49 CFR 28.131 - Illegal use of drugs.

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Illegal use of drugs. 28.131 Section 28.131 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION § 28.131 Illegal use of...

Molecular characterization of a human G20P[28] rotavirus a strain with multiple genes related to bat rotaviruses.

Science.gov (United States)

Esona, Mathew D; Roy, Sunando; Rungsrisuriyachai, Kunchala; Gautam, Rashi; Hermelijn, Sandra; Rey-Benito, Gloria; Bowen, Michael D

2018-01-01

Group A rotaviruses are the major cause of severe gastroenteritis in the young of mammals and birds. This report describes characterization of an unusual G20P[28] rotavirus strain detected in a 24month old child from Suriname. Genomic sequence analyses revealed that the genotype constellation of the Suriname strain RVA/Human-wt/SUR/2014735512/2013/G20P[28] was G20-P[28]-I13-R13-C13-M12-A23-N13-T15-E20-H15. Genes VP1, VP2, VP3, NSP1, NSP2, NSP3, NSP4 and NSP5 were recently assigned novel genotypes by the Rotavirus Classification Working Group (RCWG). Three of the 11 gene segments (VP7, VP4, VP6) were similar to cognate gene sequences of bat-like human rotavirus strain Ecu534 from Ecuador and the VP7, NSP3 and NSP5 gene segments of strain RVA/Human-wt/SUR/2014735512/2013/G20P[28] were found to be closely related to gene sequences of bat rotavirus strain 3081/BRA detected in Brazil. Although distantly related, the VP1 gene of the study strain and bat strain BatLi09 detected in Cameroon in 2014 are monophyletic. The NSP1 gene was found to be most closely related to human strain QUI-35-F5 from Brazil. These findings suggest that strain RVA/Human-wt/SUR/2014735512/2013/G20P[28] represents a zoonotic infection from a bat host. Published by Elsevier B.V.

Osteomyelitis of the calcaneus in horses: 28 cases (1972-1987)

International Nuclear Information System (INIS)

MacDonald, M.H.; Honnas, C.M.; Meagher, D.M.

1989-01-01

Medical records of 28 horses with osteomyelitis of the calcaneus were reviewed to evaluate signalment, history, diagnostic and treatment methods, outcome, and long-term follow-up information. Trauma was the most commonly reported cause (24). Physical examination revealed lameness in 27 horses, and 22 (79%) had a wound or draining tract over the plantar aspect of the calcaneus. Radiography of all horses was done prior to the initiation of treatment, and follow-up radiography was done on 20 horses. The most common radiographic findings were soft tissue swelling (25), bony lysis of the calcaneus (17), bone fragments or sequestra from the tuber calcis (13), and periosteal new bone production or bony lysis of the sustentaculum tali (5). Association could not be found between initial radiographic findings and eventual outcome of the case. Positive bacterial cultures were obtained from 13 horses. A wide variety of gram-positive, gram-negative, and anaerobic organisms were isolated. Fourteen of the 15 isolates, for which susceptibilities were reported, were susceptible to penicillin, gentamicin, or trimethoprim sulfamethoxazole. Twenty-six of the 28 horses diagnosed as having osteomyelitis of the calcaneus were treated; 16 horses were treated with surgical debridement in addition to antimicrobial treatment, and 10 horses were treated with antimicrobial agents, anti-inflammatory drugs, or supportive wound care. There was no significant difference in survival rate of horses treated surgically and those treated conservatively. Six horses that were treated were later euthanatized for problems associated with chronic osteomyelitis, and 2 horses died or were euthanatized for unrelated problems. Eighteen horses (64%) were alive at last follow-up

Effects of 2,4-D and DCP on the DHT-induced androgenic action in human prostate cancer cells.

Science.gov (United States)

Kim, Hyun-Jung; Park, Young In; Dong, Mi-Sook

2005-11-01

2,4-Dichlorophenoxyacetic acid (2,4-D) and its metabolite 2,4-dichlorophenol (DCP) are used extensively in agriculture as herbicides, and are suspected of potential endocrine disruptor activity. In a previous study, we showed that these compounds exhibited synergistic androgenic effects by co-treatment with testosterone in the Hershberger assay. To elucidate the mechanisms of the synergistic effects of these compounds on the androgenicity of testosterone, the androgenic action of 2,4-D and DCP was characterized using a mammalian detection system in prostate cancer cell lines. In in vitro assay systems, while 2,4-D or DCP alone did not show androgenic activity, 2,4-D or DCP with 5alpha-dihydroxytestosterone (DHT) exhibited synergistic androgenic activities. Co-treatment of 10 nM 2,4-D or DCP with 10 nM DHT was shown to stimulate the cell proliferation by 1.6-fold, compared to 10 nM DHT alone. In addition, in transient transfection assays, androgen-induced transactivation was also increased to a maximum of 32-fold or 1.28-fold by co-treatment of 2,4-D or DCP with DHT, respectively. However, 2,4-D and DCP exerted no effects on either mRNA or protein levels of AR. In a competitive AR binding assay, 2,4-D and DCP inhibited androgen binding to AR, up to 50% at concentrations of approximately 0.5 microM for both compounds. The nuclear translocation of green fluorescent protein-AR fusion protein in the presence of DHT was promoted as the result of the addition of 2,4-D and DCP. Collectively, these results that 2,4-D and DCP enhanced DHT-induced AR transcriptional activity might be attributable, at least in part, to the promotion of AR nuclear translocation.

1228-IJBCS-Article-Honnoryf Tchibozo

African Journals Online (AJOL)

KODJIO NORBERT

assainissement et l'estimation de l'impact sanitaire pour les populations riveraines de la ville de Cotonou au Bénin. Une enquête méthodologique basée sur des questionnaires a été réalisée du 21 septembre 2010 au 15 janvier 2011, dans.

Reduction des effectifs ou licenciements

CERN Multimedia

Maiani, Luciano

2002-01-01

"Vous faites un amalgame entre la reduction en cours des effectifs du CERN (organisation europeenne pour la recherche nucleaire) et les economies que le laboratoire doit realiser dans les cinq ans a venir pour financer le projet de grand collisionneur de hadrons (Le Monde du 4 septembre)" (1/2 page).

: tous les projets | Page 266 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le gouvernement indien s'est formellement engagé à oeuvrer en faveur du développement et de l'autonomisation de la communauté musulmane du pays. Date de début : 5 décembre 2010. End Date: 11 septembre 2013. Sujet: RELIGIOUS MINORITIES, MUSLIMS, NONGOVERNMENTAL ORGANIZATIONS, Civil society, ...

: tous les projets | Page 566 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Date de début : 3 septembre 2006. Sujet: RESEARCH NETWORKS, ACCESS TO HEALTH CARE, HEALTH SURVEYS, HEALTH POLICY, HEALTH SERVICES. Région: North of Sahara, South of Sahara, Benin, Ivory Coast, Mali, Switzerland. Programme: Santé des mères et des enfants. Financement total : CA$ 874,011.00.

CD28: Direct and Critical Receptor for Superantigen Toxins

Directory of Open Access Journals (Sweden)

Ziv Rotfogel

2013-09-01

Full Text Available Every adaptive immune response requires costimulation through the B7/CD28 axis, with CD28 on T-cells functioning as principal costimulatory receptor. Staphylococcal and streptococcal superantigen toxins hyperstimulate the T-cell-mediated immune response by orders of magnitude, inducing a lethal cytokine storm. We show that to elicit an inflammatory cytokine storm and lethality, superantigens must bind directly to CD28. Blocking access of the superantigen to its CD28 receptor with peptides mimicking the contact domains in either toxin or CD28 suffices to protect mice effectively from lethal shock. Our finding that CD28 is a direct receptor of superantigen toxins broadens the scope of microbial pathogen recognition mechanisms.

7 CFR 28.115 - Fees and costs; payment.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Fees and costs; payment. 28.115 Section 28.115... Fees and Costs § 28.115 Fees and costs; payment. All charges for practical forms of cotton standards and all fees and expenses for services of inspection of bales and supervision of sampling...

27 CFR 5.28 - Adoption of predecessor's formulas.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Adoption of predecessor's formulas. 5.28 Section 5.28 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF DISTILLED SPIRITS Formulas § 5.28 Adoption of...

The dissipation and risk assessment of 2,4-D sodium, a preharvest anti-fruit-drop plant hormone in bayberries.

Science.gov (United States)

Zhao, Huiyu; Yang, Guiling; Liang, Senmiao; Huang, Qianbin; Wang, Qiang; Dai, Wanze; Zhang, Zhiheng; Wang, Wen; Song, Wen; Cai, Zheng

2017-11-01

Preharvest fruit-drop is a challenge to bayberry production. 2,4-D sodium as a commonly used anti-fruit-drop hormone on bayberry can reduce the yield loss caused by preharvest fruit-drop. The persistence and risk assessment of 2,4-D sodium after applying on bayberries were investigated. A method for determining 2,4-D sodium in bayberry was established based on LC-MS-MS. The average recoveries of 2,4-D sodium were at the range of 93.7-95.8% with relative standard deviations (RSDs) ranging from 0.9 to 2.8%. The dissipation rates of 2,4-D sodium were described using first-order kinetics, and its half-life ranged from 11.2 to 13.8 days. A bayberry consumption survey was carried out for Chinese adults for the first time. The safety assessments of 2,4-D sodium were conducted by using field trail data as well as monitoring data. Results showed that the chronic risk quotient and the acute risk quotient were calculated to be 0.23-0.59 and 0.02-0.05%, respectively, for Chinese adults, indicating low dietary risk for adults and children. In the end, the household cleaning steps were compared, and results showed that water rinsing for 1 min can remove 49.9% 2,4-D sodium residue, which provides pesticide removal suggestion for consumers.

7 CFR 28.434 - Low Middling Tinged Color.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Low Middling Tinged Color. 28.434 Section 28.434... REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Standards Tinged Cotton § 28.434 Low Middling Tinged Color. Low Middling Tinged Color is color which is within the range represented by a set of samples in the...

4 CFR 28.89 - Attorney's fees and costs.

Science.gov (United States)

2010-01-01

... 4 Accounts 1 2010-01-01 2010-01-01 false Attorney's fees and costs. 28.89 Section 28.89 Accounts... Procedures Board Decisions, Attorney's Fees and Judicial Review § 28.89 Attorney's fees and costs. Within 20... party, may submit a request for the award of reasonable attorney's fees and costs. GAO may file a...

46 CFR 28.805 - Launching of survival craft.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Launching of survival craft. 28.805 Section 28.805... FISHING INDUSTRY VESSELS Aleutian Trade Act Vessels § 28.805 Launching of survival craft. In addition to the survival craft requirements in subpart B, each vessel must have a gate or other opening in the...

Electronic structure of Pa at sign C28

International Nuclear Information System (INIS)

Zhao, Ke; Pitzer, R.M.

1995-01-01

The electronic structure of the endohedral complex Pa at sign C 28 was studied using ab initio quantum chemical methods including relativistic core potentials, gaussian double zeta basis sets, and spin-orbit configuration interaction calculations. As in U at sign C 28 , the self consistent field population analysis shows extensive mixing of Pa 6d and 5f orbitals with C π orbitals, indicating strong binding. The energy of the C 28 cage π* orbitals (e symmetry) is lower than that of the Pa 5f orbitals. The ground state has an e 1 configuration at both the SCF and CI level calculations. The lowest f 1 state is 1.68 eV and 1.70 eV above the ground state from SCF and CI calculations respectively. Previous calculations on U at sign C 28 showed that the ground state of U at sign C 28 is a π*f state instead of an f 2 state. The results for Pa at sign C 28 support that finding

Evaluation des rendements en graines et fanes des variétés

African Journals Online (AJOL)

(L.) Walp.) au Niger avec mention spéciale au Macrophomina phaseolina (Tassi) Goid. Thèse de doctorat, Université de Niamey,. 117p. Addam K. S. 1999. Effet de l'azote et du phosphore sur la nutrition azotée des variétés de niébé. (Vigna unguiculata (L.) Walp.) présélection- nées au Niger. DEA, physiologie végétale.

Publications | Page 230 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Fin des deux solitudes de l'élevage et de l'agriculture au Sahel (open access). Les femmes de Toukounous, petite localité située à 20 km de Niamey, participent à un moment charnière de l''histoire agricole du Niger et du Sahel. En effet, leur région ne vit que maintenant l''intégration de l''agriculture et de l''élevage, étape ...

3D Structure and Interaction of p24β and p24δ Golgi Dynamics Domains: Implication for p24 Complex Formation and Cargo Transport.

Science.gov (United States)

Nagae, Masamichi; Hirata, Tetsuya; Morita-Matsumoto, Kana; Theiler, Romina; Fujita, Morihisa; Kinoshita, Taroh; Yamaguchi, Yoshiki

2016-10-09

The p24 family consists of four subfamilies (p24α, p24β, p24γ, and p24δ), and the proteins are thought to form hetero-oligomeric complexes for efficient transport of cargo proteins from the endoplasmic reticulum to the Golgi apparatus. The proteins possess a conserved luminal Golgi dynamics (GOLD) domain, whose functions are largely unknown. Here, we present structural and biochemical studies of p24β1 and p24δ1 GOLD domains. Use of GOLD domain-deleted mutants revealed that the GOLD domain of p24δ1 is required for proper p24 hetero-oligomeric complex formation and efficient transport of GPI-anchored proteins. The p24β1 and p24δ1 GOLD domains share a common β-sandwich fold with a characteristic intrasheet disulfide bond. The GOLD domain of p24δ1 crystallized as dimers, allowing the analysis of a homophilic interaction site. Surface plasmon resonance and solution NMR analyses revealed that p24β1 and p24δ1 GOLD domains interact weakly (K d = ~10 -4 M). Bi-protein titration provided interaction site maps. We propose that the heterophilic interaction of p24 GOLD domains contributes to the formation of the p24 hetero-oligomeric complex and to efficient cargo transport. Copyright © 2016 Elsevier Ltd. All rights reserved.

7 CFR 28.406 - Strict Good Ordinary Color.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Strict Good Ordinary Color. 28.406 Section 28.406... for the Color Grade of American Upland Cotton § 28.406 Strict Good Ordinary Color. Strict Good Ordinary Color is color which is within the range represented by a set of samples in the custody of the...

7 CFR 28.404 - Strict Low Middling Color.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Strict Low Middling Color. 28.404 Section 28.404... for the Color Grade of American Upland Cotton § 28.404 Strict Low Middling Color. Strict Low Middling Color is color which is within the range represented by a set of samples in the custody of the United...

46 CFR 28.310 - Launching of survival craft.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Launching of survival craft. 28.310 Section 28.310... Operate With More Than 16 Individuals on Board § 28.310 Launching of survival craft. A gate or other... each survival craft which weighs more than 110 pounds (489 Newtons), to allow the survival craft to be...

MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastoma

Science.gov (United States)

Beckers, Anneleen; Van Peer, Gert; Carter, Daniel R.; Gartlgruber, Moritz; Herrmann, Carl; Agarwal, Saurabh; Helsmoortel, Hetty H.; Althoff, Kristina; Molenaar, Jan J.; Cheung, Belamy B.; Schulte, Johannes H.; Benoit, Yves; Shohet, Jason M.; Westermann, Frank; Marshall, Glenn M.; Vandesompele, Jo; De Preter, Katleen; Speleman, Frank

2016-01-01

LIN28B has been identified as an oncogene in various tumor entities, including neuroblastoma, a childhood cancer that originates from neural crest-derived cells, and is characterized by amplification of the MYCN oncogene. Recently, elevated LIN28B expression levels were shown to contribute to neuroblastoma tumorigenesis via let-7 dependent de-repression of MYCN. However, additional insight in the regulation of LIN28B in neuroblastoma is lacking. Therefore, we have performed a comprehensive analysis of the regulation of LIN28B in neuroblastoma, with a specific focus on the contribution of miRNAs. We show that MYCN regulates LIN28B expression in neuroblastoma tumors via two distinct parallel mechanisms. First, through an unbiased LIN28B-3′UTR reporter screen, we found that miR-26a-5p and miR-26b-5p regulate LIN28B expression. Next, we demonstrated that MYCN indirectly affects the expression of miR-26a-5p, and hence regulates LIN28B, therefor establishing a MYCN-miR-26a-5p-LIN28B regulatory axis. Second, we provide evidence that MYCN regulates LIN28B expression via interaction with the LIN28B promotor, establishing a direct MYCN-LIN28B regulatory axis. We believe that these findings mark LIN28B as an important effector of the MYCN oncogenic phenotype and underlines the importance of MYCN-regulated miRNAs in establishing the MYCN-driven oncogenic process. PMID:26123663

41 CFR 109-28.000-50 - Policy.

Science.gov (United States)

2010-07-01

... industrial management practices and principles. ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Policy. 109-28.000-50 Section 109-28.000-50 Public Contracts and Property Management Federal Property Management Regulations...

Influence of 28-O-propynoylbetulin on proliferation and apoptosis of melanotic and amelanotic human melanoma cells

Directory of Open Access Journals (Sweden)

Anna Kaps

2016-12-01

Full Text Available Introduction: A relatively new approach in treatment of malignant melanoma is the use of betulin and its synthetic derivatives that have anticancer properties. The aim of the study was to determine the effect of an acetylenic derivative of betulin, 28-O-propynoylbetulin, on cell growth and apoptosis induction in human melanotic and amelanotic melanoma cells.Materials and methods: The A2058 and C32 cell lines were incubated with 28-O-propynoylbetulin (working solutions from 0.1 to 10 μg/ml. To evaluate cell proliferation, a sulforhodamine B based assay was conducted. In order to elucidate the early stages of apoptosis in both melanoma cell lines, caspase-3 activity was evaluated.Results: The administration of 28-O-propynoylbetulin at a concentration equal to or less than 1 μg/ml did not cause a statistically significant change in the cell proliferation in either melanoma cell line (compared to control, p>0.05. Higher concentrations of the compound (3 and 10 μg/ml inhibited the cell growth (in comparison to control, p<0.05. These results corresponded with caspase-3 activity results that revealed an increase of enzyme activity after 24-hour incubation with 3 and 10 μg/ml of the compound (compared to control, p<0.05.Discussion: The study revealed that 28-O-propynoylbetulin may have diverse effects on melanoma cells and could be a strong inhibitor of cell growth (C32 cells or exert a more potent proapoptotic effect (A2058 cells. These findings support the possibility of the use of EB5 in different antimelanoma approaches.

Hormone withdrawal-associated symptoms with ethinylestradiol 20 µg/drospirenone 3 mg (24/4 regimen versus ethinylestradiol 20 µg/desogestrel 150 µg (21/7 regimen

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Bitzer J

2015-05-01

Full Text Available Johannes Bitzer,1 Maria Jesusa Banal-Silao,2 Hans-Joachim Ahrendt,3 Jaime Restrepo,4 Marion Hardtke,5 Ulrike Wissinger-Graefenhahn,6 Dietmar Trummer7 1Department of Obstetrics and Gynecology, University Hospital of Basel, Basel, Switzerland; 2University of the Philippines College of Medicine, Manila, Philippines; 3Praxis für Frauenheilkunde, Klinische Forschung und Weiterbildung (Clinical Research and Further Education, Magdeburg, Germany; 4Centro de Investigación Clínica, Clinica Medellin Poblado, Medellin, Colombia; 5Global Clinical Development Operations, Bayer Pharma AG, Berlin, Germany; 6Global Medical Affairs Women’s Healthcare, Bayer Pharma AG, Berlin, Germany; 7Clinical Statistics Europe, Bayer Pharma AG, Berlin, Germany Objective: To assess whether the combined oral contraceptive (COC ethinylestradiol (EE 20 µg/drospirenone 3 mg taken in a 24/4-day regimen (ie, 4-day hormone-free interval is more effective than an EE 20 µg/desogestrel (DSG 150 µg COC taken in a 21/7-day regimen (ie, 7-day hormone-free interval in reducing hormone withdrawal-associated symptoms (HWAS.Methods: This double-blind, randomized study (NLM identifier: NCT01076582 was conducted at 34 centers in 12 countries. Otherwise healthy women who experienced ≥2 HWAS of headache, pelvic pain, and/or bloating when using their current COCs in a 21/7-day regimen were recruited. Subjects rated the severity of their HWAS daily on a seven-point Likert scale during a baseline cycle and during four 28-day cycles with EE/drospirenone 24/4 (n=290 or EE/DSG 21/7 (n=304. The primary variable was the mean change from baseline to cycle 4 in the composite HWAS score (sum of scores for all three symptoms during cycle days 22–28.Results: In the EE/drospirenone 24/4 group, the mean (standard deviation composite HWAS score during cycle days 22–28 was reduced from 42.2 (24.8 at baseline to 12.8 (13.4 at cycle 4 (change from baseline: -30.3 [22.9]. In the EE/DSG 21/7 group, the

Biodegradation of 2,4-dichlorophenol by shiitake mushroom (Lentinula edodes) using vanillin as an activator.

Science.gov (United States)

Tsujiyama, S; Muraoka, T; Takada, N

2013-07-01

The white-rot shiitake mushroom, Lentinula edodes, was used to degrade an environmentally hazardous compound, 2,4-dichlorophenol (DCP), using vanillin as an activator. Vanillin increased the mycelial growth from 74 to 118 mg/150 ml culture and accelerated laccase and Mn-peroxidase production from the maximum on days 24-28 without vanillin to days 10-14. It eliminated 92% of 100 mM DCP with 50 mg vanillin/l compared with only 15% without vanillin. GC-MS revealed that a diaryl ether dimer of DCP was formed in the culture without vanillin, whereas dimer formation was diminished with vanillin addition. This indicates that vanillin enhances the degradation of DCP and disrupts the formation of the toxic dimer. Therefore, lignin-derived phenol such as vanillin can be used as natural and eco-friendly activators to control white-rot mushrooms, thereby facilitating the effective degradation of environmentally hazardous compounds.

The Metalloproteinase ADAM28 Promotes Metabolic Dysfunction in Mice

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Lakshini Herat

2017-04-01

Full Text Available Obesity and diabetes are major causes of morbidity and mortality globally. The current study builds upon our previous association studies highlighting that A Disintegrin And Metalloproteinase 28 (ADAM28 appears to be implicated in the pathogenesis of obesity and type 2 diabetes in humans. Our novel study characterised the expression of ADAM28 in mice with the metabolic syndrome and used molecular inhibition approaches to investigate the functional role of ADAM28 in the pathogenesis of high fat diet-induced obesity. We identified that ADAM28 mRNA and protein expression was markedly increased in the livers of mice with the metabolic syndrome. In addition, noradrenaline, the major neurotransmitter of the sympathetic nervous system, results in elevated Adam28 mRNA expression in human monocytes. Downregulation of ADAM28 with siRNA technology resulted in a lack of weight gain, promotion of insulin sensitivity/glucose tolerance and decreased liver tumour necrosis factor-α (TNF-α levels in our diet-induced obesity mouse model as well as reduced blood urea nitrogen, alkaline phosphatase and aspartate aminotransferase. In addition, we show that ADAM28 knock-out mice also displayed reduced body weight, elevated high density lipoprotein cholesterol levels, and reductions in blood urea nitrogen, alkaline phosphatase, and aspartate aminotransferase. The results of this study provide important insights into the pathogenic role of the metalloproteinase ADAM28 in the metabolic syndrome and suggests that downregulation of ADAM28 may be a potential therapeutic strategy in the metabolic syndrome.

Quantum chemical calculations and molecular docking studies of 5-(4-chlorobenzylidene)thiazolidine-2,4-dione(CTD) and its mannich product 5-(4-chlorobenzylidene)-3-(morpholinomethyl)thiazolidine-2,4-dione (CMTD)

Science.gov (United States)

Fatma, Shaheen; Bishnoi, Abha; Verma, Anil Kumar; Singh, Vineeta; Srivastava, Krishna

2018-04-01

This work presents the synthesis of 5-(4-chlorobenzylidene)thiazolidine-2,4-dione (CTD) by Claisen condensation of thiazolidine-2,4-dione and mannich product of CTD, 5-(4-chlorobenzylidene)-3-(morpholinomethyl)thiazolidine-2,4-dione (CMTD). The static first hyperpolarizability values for thiazolidine-2,4-dione derivatives have been calculated as 10.28 × 10-30 esu for CTD and 19.42 × 10-30 esu for CMTD. The gradual increase in hyperpolarizability values of synthesized thiazolidine-2,4-dione derivatives from CTD to CMTD is due to the blockage of sbnd NH group on CTD by mannich reaction. The structures of these compounds have been derived by spectroscopic(IR, UV, Mass, 1H and 13C NMR) analysis as well as with the help of theoretical studies. The high values of first static hyperpolarizability indicate that the synthesized derivatives are suitable as non-linear optical (NLO) material. CTD with MIC value of 12.5 μg/mL can be developed as an alternative drug for the treatment of enteric fever. Calculated frontier orbital gap values suggest that the CMTD is a soft molecule with high chemical reactivity and is more polarizable as compared to the CTD. Molecular electrostatic potential is calculated for the optimized geometry of the molecules to estimate their chemical reactivity. The inhibitor CTD forms a stable complex with 3-dehydroquinase enzyme of Salmonella typhi. It is evident from the ligand receptor interactions and a binding affinity value of -5.88 kcal/mol and an inhibition constant of 49.22 μM. This is further confirmed by the experimental biological data. The molecular docking studies are supportive of the antibacterial activity of CTD exhibiting high inhibition constant and binding energy.

Energy dependence of fusion evaporation-residue cross sections in the 28Si+28Si reaction

International Nuclear Information System (INIS)

Vineyard, M.F.; Bauer, J.S.; Gosdin, C.H.; Trotter, R.S.; Kovar, D.G.; Beck, C.; Henderson, D.J.; Janssens, R.V.F.; Wilkins, B.D.; Rosner, G.; Chowdhury, P.; Ikezoe, H.; Kuhn, W.; Kolata, J.J.; Hinnefeld, J.D.; Maguire, C.F.; Mateja, J.F.; Prosser, F.W.; Stephans, G.S.F.

1990-01-01

Velocity distributions of mass-identified evaporation residues produced in the 28 Si+ 28 Si reaction have been measured at bombarding energies of 174, 215, 240, 309, 397, and 452 MeV using time-of-flight techniques. These distributions were used to identify evaporation residues and to separate the complete-fusion and incomplete-fusion components. Angular distributions and total cross sections were extracted at all six bombarding energies. The complete-fusion evaporation-residue cross sections and the deduced critical angular momenta are compared with lower energy data and the predictions of existing models

Being in control? A thematic content analysis of 14 in-depth interviews with 2,4-dinitrophenol users.

Science.gov (United States)

Ainsworth, Neha Prasad; Vargo, Elisabeth Julie; Petróczi, Andrea

2018-02-01

2,4-Dinitrophenol (2,4-DNP) is a compound with multiple industrial purposes. Currently unlicensed for human consumption, it is used by the gym-going population for drastic, short-term body fat loss. Nonetheless, physiological mechanisms can lead to potentially fatal hyperthermia. Reported fatal incidents have caused concern and highlighted the need for intervention. Understanding decision-making leading to 2,4-DNP use alongside the perceived outgroup attitudes is vital to forming effective harm minimisation policies targeting current and potential users. First-hand accounts from this elusive population are scarce. Fourteen novel and experienced users (13 male, 1 female) were recruited via "snowballing" techniques. Semi-structured interviews were conducted, comprising 28 questions. Thematic content analysis was conducted using 37 codes. Four characteristic themes emerged: 1. Users considered the Internet to be a crucial multifunctional resource directly impacting their 2,4-DNP use. 2. Users "respected" 2,4-DNP, proactively taking harm reduction measures. 3. Attitudinal polarisation towards 2,4-DNP within the gym-going community was consistent in all accounts. 4. Users perceived outgroup populations to have inherently negative attitudes towards their use. These themes fell under the all-encompassing theme of "being in control". For the first time, this study offers a rich detail of attitudes toward 2,4-DNP use by giving a collective voice to users. The element of control over every aspect of the users' life appears to be a significant contributor to the successful risk-management of 2,4-DNP use. In the absence of an established safe upper limit and effective regulatory control, education is critical to harm minimisation. Copyright © 2017 Elsevier B.V. All rights reserved.

Recurrent Bleeding Within 24 Hours After Uterine Artery Embolization for Severe Postpartum Hemorrhage: Are There Predictive Factors?

International Nuclear Information System (INIS)

Bros, Sébastien; Chabrot, Pascal; Kastler, Adrian; Ouchchane, Lemlih; Cassagnes, Lucie; Gallot, Denis; Boyer, Louis

2012-01-01

Purpose: To retrospectively identify predictive factors of recurrent bleeding within 24 h after uterine artery embolization (UAE) for postpartum hemorrhage (PPH). Materials and Methods: A total of 194 patients underwent UAE for PPH between August 1999 and April 2009 at our institution. Twelve patients experienced recurrent bleeding within the next 24 h; a second attempt at UAE was thus necessary, which was successful in 10 cases. In two cases, hemostatic hysterectomy was performed. Epidemiological, gynecological-obstetrical, anatomic, and biological data were analyzed. Results: Complete data were available for 148 of the 194 (76%) included patients. Sixty-four (43%) were primiparous, 18 (12.2%) had a placenta accreta, 21 (14%) had a coagulopathy, and 28 (18.9%) had an anatomic variant of the uterine arterial vasculature. Mean age and pregnancy term were similar in both recurring and nonrecurrent bleeding groups. After multivariate analysis, three criteria emerged as risk factors of recurrent bleeding: primiparity (10 patients, 83%; odds ratio [OR] = 18.84; P = 0.014), coagulation disorders (6 patients, 50%; OR = 12.08; P = 0.006), and anatomic variant of the uterine arterial vasculature (28 patients; OR = 9.83; P = 0.003). Conclusions: earch for uterine collaterals must be performed before UAE for PPH. Primiparity and coagulation disorders increase the risk of recurrent bleeding after UAE for PPH.

: tous les projets | Page 508 | CRDI - Centre de recherches pour le ...

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En 2002, l'Angola émergeait de 40 ans de conflit, l'une des plus longues guerres civiles qu'ait connues l'Afrique. Date de début : 13 mars 2007. End Date: 7 septembre 2009. Sujet: ECONOMIC RECONSTRUCTION, INFORMAL SECTOR, INCOME GENERATION, EMPLOYMENT, SOCIAL EQUITY. Région: Angola, North of ...

La largeur de bande pourrait permettre aux universités africaines de ...

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2 févr. 2011 ... La meilleure politique une recherche en télécommunication dans une ... Toutefois, l'utilisation de HINARI exige un accès Internet fiable et assez .... à la conférence d'Internet2, qui a eu lieu aux États-Unis en septembre, et à ...

32 CFR 634.28 - Traffic accident investigation.

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2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true Traffic accident investigation. 634.28 Section... ENFORCEMENT AND CRIMINAL INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION Traffic Supervision § 634.28 Traffic accident investigation. Installation law enforcement personnel must make detailed investigations of...

Connective tissue growth factor is a substrate of ADAM28

International Nuclear Information System (INIS)

Mochizuki, Satsuki; Tanaka, Rena; Shimoda, Masayuki; Onuma, Junko; Fujii, Yutaka; Jinno, Hiromitsu; Okada, Yasunori

2010-01-01

Research highlights: → The hyper-variable region in the cysteine-rich domain of ADAM28 binds to C-terminal domain of CTGF. → ADAM28 cleaves CTGF alone and CTGF in the CTGF/VEGF 165 complex. → CTGF digestion by ADAM28 releases biologically active VEGF 165 from the complex. → ADAM28, CTGF and VEGF 165 are commonly co-expressed by carcinoma cells in human breast carcinoma tissues. → These suggest that ADAM28 promotes VEGF 165 -induced angiogenesis in the breast carcinomas by selective CTGF digestion in the CTGF/VEGF 165 complex. -- Abstract: ADAM28, a member of the ADAM (a disintegrin and metalloproteinase) gene family, is over-expressed by carcinoma cells and the expression correlates with carcinoma cell proliferation and progression in human lung and breast carcinomas. However, information about substrates of ADAM28 is limited. We screened interacting molecules of ADAM28 in human lung cDNA library by yeast two-hybrid system and identified connective tissue growth factor (CTGF). Binding of CTGF to proADAM28 was demonstrated by yeast two-hybrid assay and protein binding assay. ADAM28 cleaved CTGF in dose- and time-dependent manners at the Ala 181 -Tyr 182 and Asp 191 -Pro 192 bonds in the hinge region of the molecule. ADAM28 selectively digested CTGF in the complex of CTGF and vascular endothelial growth factor 165 (VEGF 165 ), releasing biologically active VEGF 165 from the complex. RT-PCR and immunohistochemical analyses demonstrated that ADAM28, CTGF and VEGF are commonly co-expressed in the breast carcinoma tissues. These data provide the first evidence that CTGF is a novel substrate of ADAM28 and suggest that ADAM28 may promote VEGF 165 -induced angiogenesis in the breast carcinomas by the CTGF digestion in the CTGF/VEGF 165 complex.

ASA24-Canada

Science.gov (United States)

A Canadian adaptation of the Automated Self-Administered 24-hour Dietary Assessment Tool (ASA24-Canada), developed by the Food Directorate at Health Canada in collaboration with NCI, has been freely available since April 2014.

Cycloartane-3,24,25-triol inhibits MRCKα kinase and demonstrates promising anti prostate cancer activity in vitro

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Lowe Henry I C

2012-11-01

Full Text Available Abstract Background Given the high occurrence of prostate cancer worldwide and one of the major sources of the discovery of new lead molecules being medicinal plants, this research undertook to investigate the possible anti-cancer activity of two natural cycloartanes; cycloartane-3,24,25-diol (extracted in our lab from Tillandsia recurvata and cycloartane-3,24,25-triol (purchased. The inhibition of MRCKα kinase has emerged as a potential solution to restoring the tight regulation of normal cellular growth, the loss of which leads to cancer cell formation. Methods Kinase inhibition was investigated using competition binding (to the ATP sites assays which have been previously established and authenticated and cell proliferation was measured using the WST-1 assay. Results Cycloartane-3,24,25-triol demonstrated strong selectivity towards the MRCKα kinase with a Kd50 of 0.26 μM from a total of 451 kinases investigated. Cycloartane-3,24,25-triol reduced the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively. Conclusions These results will prove useful in drug discovery as Cycloartane-3,24,25-triol has shown potential for development as an anti-cancer agent against prostate cancer.

Cycloartane-3,24,25-triol inhibits MRCKα kinase and demonstrates promising anti prostate cancer activity in vitro

Science.gov (United States)

2012-01-01

Background Given the high occurrence of prostate cancer worldwide and one of the major sources of the discovery of new lead molecules being medicinal plants, this research undertook to investigate the possible anti-cancer activity of two natural cycloartanes; cycloartane-3,24,25-diol (extracted in our lab from Tillandsia recurvata) and cycloartane-3,24,25-triol (purchased). The inhibition of MRCKα kinase has emerged as a potential solution to restoring the tight regulation of normal cellular growth, the loss of which leads to cancer cell formation. Methods Kinase inhibition was investigated using competition binding (to the ATP sites) assays which have been previously established and authenticated and cell proliferation was measured using the WST-1 assay. Results Cycloartane-3,24,25-triol demonstrated strong selectivity towards the MRCKα kinase with a Kd50 of 0.26 μM from a total of 451 kinases investigated. Cycloartane-3,24,25-triol reduced the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively. Conclusions These results will prove useful in drug discovery as Cycloartane-3,24,25-triol has shown potential for development as an anti-cancer agent against prostate cancer. PMID:23151005

Mapping health assessment questionnaire disability index (HAQ-DI) score, pain visual analog scale (VAS), and disease activity score in 28 joints (DAS28) onto the EuroQol-5D (EQ-5D) utility score with the KORean Observational study Network for Arthritis (KORONA) registry data.

Science.gov (United States)

Kim, Hye-Lin; Kim, Dam; Jang, Eun Jin; Lee, Min-Young; Song, Hyun Jin; Park, Sun-Young; Cho, Soo-Kyung; Sung, Yoon-Kyoung; Choi, Chan-Bum; Won, Soyoung; Bang, So-Young; Cha, Hoon-Suk; Choe, Jung-Yoon; Chung, Won Tae; Hong, Seung-Jae; Jun, Jae-Bum; Kim, Jinseok; Kim, Seong-Kyu; Kim, Tae-Hwan; Kim, Tae-Jong; Koh, Eunmi; Lee, Hwajeong; Lee, Hye-Soon; Lee, Jisoo; Lee, Shin-Seok; Lee, Sung Won; Park, Sung-Hoon; Shim, Seung-Cheol; Yoo, Dae-Hyun; Yoon, Bo Young; Bae, Sang-Cheol; Lee, Eui-Kyung

2016-04-01

The aim of this study was to estimate the mapping model for EuroQol-5D (EQ-5D) utility values using the health assessment questionnaire disability index (HAQ-DI), pain visual analog scale (VAS), and disease activity score in 28 joints (DAS28) in a large, nationwide cohort of rheumatoid arthritis (RA) patients in Korea. The KORean Observational study Network for Arthritis (KORONA) registry data on 3557 patients with RA were used. Data were randomly divided into a modeling set (80 % of the data) and a validation set (20 % of the data). The ordinary least squares (OLS), Tobit, and two-part model methods were employed to construct a model to map to the EQ-5D index. Using a combination of HAQ-DI, pain VAS, and DAS28, four model versions were examined. To evaluate the predictive accuracy of the models, the root-mean-square error (RMSE) and mean absolute error (MAE) were calculated using the validation dataset. A model that included HAQ-DI, pain VAS, and DAS28 produced the highest adjusted R (2) as well as the lowest Akaike information criterion, RMSE, and MAE, regardless of the statistical methods used in modeling set. The mapping equation of the OLS method is given as EQ-5D = 0.95-0.21 × HAQ-DI-0.24 × pain VAS/100-0.01 × DAS28 (adjusted R (2) = 57.6 %, RMSE = 0.1654 and MAE = 0.1222). Also in the validation set, the RMSE and MAE were shown to be the smallest. The model with HAQ-DI, pain VAS, and DAS28 showed the best performance, and this mapping model enabled the estimation of an EQ-5D value for RA patients in whom utility values have not been measured.

28 CFR 2.21 - Reparole consideration guidelines.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Reparole consideration guidelines. 2.21....21 Reparole consideration guidelines. (a)(1) If revocation is based upon administrative violation(s... analogy with listed federal offense behaviors. (b) The guidelines for parole consideration specified at 28...

Safety and effectiveness of 24-week treatment with iguratimod, a new oral disease-modifying antirheumatic drug, for patients with rheumatoid arthritis: interim analysis of a post-marketing surveillance study of 2679 patients in Japan.

Science.gov (United States)

Mimori, Tsuneyo; Harigai, Masayoshi; Atsumi, Tatsuya; Fujii, Takao; Kuwana, Masataka; Matsuno, Hiroaki; Momohara, Shigeki; Takei, Syuji; Tamura, Naoto; Takasaki, Yoshinari; Ikeuchi, Satoshi; Kushimoto, Satoru; Koike, Takao

2017-09-01

To determine the real-world safety and effectiveness of iguratimod (IGU) for rheumatoid arthritis (RA), a 52-week, Japanese, post-marketing surveillance study was conducted. An interim analysis at week 24 was performed. This study included all RA patients who received IGU following its introduction to the market. All adverse events (AEs) and adverse drug reactions (ADRs) were collected. Effectiveness was evaluated by the change in Disease Activity Score 28-C-reactive protein (DAS28-CRP) from baseline to week 24. Safety was analyzed in 2679 patients. The overall incidences of AEs, ADRs, and serious ADRs were 38.41, 31.65, and 3.21%, respectively; the most commonly reported serious ADRs were pneumonia/bacterial pneumonia, interstitial lung disease, and Pneumocystis jiroveci pneumonia. Concomitant glucocorticoid use and comorbid conditions associated with respiratory disease were identified as risk factors for serious infections. Pulmonary alveolar hemorrhage and increased international normalized ratio of prothrombin time were observed with concomitant use of IGU and warfarin. The DAS28-CRP decreased from baseline to week 24. Although a safety concern was identified with concomitant use of IGU and warfarin, this real-world study showed no other new safety concerns and similar effectiveness to clinical trials. IGU is a new therapeutic option for RA patients.

Proton-threshold states in /sup 28/Si

Energy Technology Data Exchange (ETDEWEB)

Champagne, A E; Pitt, M L; Zhang, P H; Lee, Jr, L L; Levine, M J

1986-10-27

The /sup 27/Al(/sup 3/He, d)/sup 28/Si reaction has been used to locate candidates for resonances in the /sup 27/Al+p system residing near the proton-capture threshold in the energy region characteristic of quiescent stellar hydrogen burning. Two such states are observed at excitation energies E/sub x/=11.658 MeV (J/sup ..pi../=2/sup +/) and 11.671 MeV (J/sup ..pi../=1/sup -/). A comparison of the cross sections for the /sup 27/Al(/sup 3/He, d)/sup 28/Si and the /sup 27/Al(..cap alpha.., t)/sup 28/Si reactions implies angular-momentum transfers of l=2 and l=3, respectively, for the two states of interest. Using this result, an astrophysically significant upper limit on the thermonuclear reaction rate has been calculated for the /sup 27/Al(p, ..gamma..)/sup 28/Si reaction which is found to be too slow to affect the /sup 27/Al abundance in red giants.

Molecular basis for increased risk for late-onset Alzheimer disease due to the naturally occurring L28P mutation in apolipoprotein E4.

Science.gov (United States)

Argyri, Letta; Dafnis, Ioannis; Theodossiou, Theodossis A; Gantz, Donald; Stratikos, Efstratios; Chroni, Angeliki

2014-05-02

The apolipoprotein (apo) E4 isoform has consistently emerged as a susceptibility factor for late-onset Alzheimer disease (AD), although the exact mechanism is not clear. A rare apoE4 mutant, apoE4[L28P] Pittsburgh, burdens carriers with an added risk for late-onset AD and may be a useful tool for gaining insights into the role of apoE4 in disease pathogenesis. Toward this end, we evaluated the effect of the L28P mutation on the structural and functional properties of apoE4. ApoE4[L28P] was found to have significantly perturbed thermodynamic properties, to have reduced helical content, and to expose a larger portion of the hydrophobic surface to the solvent. Furthermore, this mutant is thermodynamically destabilized and more prone to proteolysis. When interacting with lipids, apoE4[L28P] formed populations of lipoprotein particles with structural defects. The structural perturbations brought about by the mutation were accompanied by aberrant functions associated with the pathogenesis of AD. Specifically, apoE4[L28P] promoted the cellular uptake of extracellular amyloid β peptide 42 (Aβ42) by human neuroblastoma SK-N-SH cells as well as by primary mouse neuronal cells and led to increased formation of intracellular reactive oxygen species that persisted for at least 24 h. Furthermore, lipoprotein particles containing apoE4[L28P] induced intracellular reactive oxygen species formation and reduced SK-N-SH cell viability. Overall, our findings suggest that the L28P mutation leads to significant structural and conformational perturbations in apoE4 and can induce functional defects associated with neuronal Aβ42 accumulation and oxidative stress. We propose that these structural and functional changes underlie the observed added risk for AD development in carriers of apoE4[L28P].

Seasonal contrast in the surface energy balance of the Sahel

Science.gov (United States)

Miller, R. L.; Slingo, A.; Barnard, J. C.; Kassianov, E.

2009-07-01

Over much of the world, heating of the surface by sunlight is balanced predominately by evaporative cooling. However, at the Atmospheric Radiation Measurement (ARM) Mobile Facility (AMF) in Niamey, Niger, evaporation makes a significant contribution to the surface energy balance only at the height of the rainy season, when precipitation has replenished the reservoir of soil moisture. The AMF was placed at Niamey from late 2005 to early 2007 to provide measurements of surface fluxes in coordination with geostationary satellite retrievals of radiative fluxes at the top of the atmosphere, as part of the RADAGAST experiment to calculate atmospheric radiative divergence. We use observations at the mobile facility to investigate how the surface adjusts to radiative forcing throughout the year. The surface response to solar heating varies with changes in atmospheric water vapor associated with the seasonal reversal of the West African monsoon, which modulates the greenhouse effect and the ability of the surface to radiate thermal energy directly to space. During the dry season, sunlight is balanced mainly by longwave radiation and the turbulent flux of sensible heat. The ability of longwave radiation to cool the surface drops after the onset of southwesterly surface winds at Niamey, when moist, oceanic air flows onshore, increasing local column moisture and atmospheric opacity. Following the onset of southwesterly flow, evaporation remains limited by the supply of moisture from precipitation. By the height of the rainy season, however, sufficient precipitation has accumulated that evaporation is controlled by incident sunlight, and radiative forcing of the surface is balanced comparably by the latent, sensible, and longwave fluxes. Evaporation increases with the leaf area index, suggesting that plants are a significant source of atmospheric moisture and may tap moisture stored beneath the surface that accumulated during a previous rainy season. Surface radiative forcing

Lin28a regulates germ cell pool size and fertility

Science.gov (United States)

Shinoda, Gen; de Soysa, T. Yvanka; Seligson, Marc T.; Yabuuchi, Akiko; Fujiwara, Yuko; Huang, Pei Yi; Hagan, John P.; Gregory, Richard I.; Moss, Eric G.; Daley, George Q.

2013-01-01

Overexpression of LIN28A is associated with human germ cell tumors and promotes primordial germ cell (PGC) development from embryonic stem cells in vitro and in chimeric mice. Knockdown of Lin28a inhibits PGC development in vitro, but how constitutional Lin28a deficiency affects the mammalian reproductive system in vivo remains unknown. Here, we generated Lin28a knockout (KO) mice and found that Lin28a deficiency compromises the size of the germ cell pool in both males and females by affecting PGC proliferation during embryogenesis. Interestingly however, in Lin28a KO males the germ cell pool partially recovers during postnatal expansion, while fertility remains impaired in both males and females mated to wild type mice. Embryonic overexpression of let-7, a microRNA negatively regulated by Lin28a, reduces the germ cell pool, corroborating the role of the Lin28a/let-7 axis in regulating the germ lineage. PMID:23378032

31 CFR 28.140 - Dissemination of policy.

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2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Dissemination of policy. 28.140 Section 28.140 Money and Finance: Treasury Office of the Secretary of the Treasury NONDISCRIMINATION ON... elementary and secondary school students, employees, sources of referral of applicants for admission and...

34 CFR 200.28 - Schoolwide program components.

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2010-07-01

... instructional program. (c) Parental involvement. (1) A schoolwide program must involve parents in the planning... 34 Education 1 2010-07-01 2010-07-01 false Schoolwide program components. 200.28 Section 200.28 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY...

7 CFR 28.952 - Testing of samples.

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2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Testing of samples. 28.952 Section 28.952 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... processing tests of the properties of cotton samples and report the results thereof to the persons from whom...

Solidarité

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Staff Association

2010-01-01

Vente de Noël au bénéfice des populations sinistrées du Togo et du Bénin    Appel d’Éducation et Libération Mardi 23 et Mercredi 24 novembre Depuis septembre, le sud du Togo et du Bénin est submergé par des pluies exceptionnellement fortes. Éducation et Libération soutient dans le sud de ces deux pays, des programmes de formation scolaire et professionnelle qui subissent les effets dévastateurs de ces pluies. Ces programmes comportent aussi un volet agricole par la mise en valeur de 13 hectares plantés en maïs, manioc et ananas bio au Bénin et par l’élevage de lapins dans les deux pays et de poules pondeuses au Togo. Écoles, ateliers, champs ont subi des dégâts mais aussi les habitations des familles, les chemins et les routes. Votre appui sera précieux...

Improvement of an enzyme-linked immunosorbent assay for equine herpesvirus type 4 by using a synthetic-peptide 24-mer repeat sequence of glycoprotein G as an antigen.

Science.gov (United States)

Bannai, Hiroshi; Nemoto, Manabu; Tsujimura, Koji; Yamanaka, Takashi; Maeda, Ken; Kondo, Takashi

2016-02-01

To increase the sensitivity of an enzyme-linked immunosorbent assay (ELISA) for equine herpesvirus type 4 (EHV-4) that uses a 12-mer peptide of glycoprotein G (gG4-12-mer: MKNNPIYSEGSL) [4], we used a longer peptide consisting of a 24-mer repeat sequence (gG4-24-mer: MKNNPIYSEGSLMLNVQHDDSIHT) as an antigen. Sera of horses experimentally infected with EHV-4 reacted much more strongly to the gG4-24-mer peptide than to the gG4-12-mer peptide. We used peptide ELISAs to test paired sera from horses naturally infected with EHV-4 (n=40). gG4-24-mer ELISA detected 37 positive samples (92.5%), whereas gG4-12-mer ELISA detected only 28 (70.0%). gG4-24-mer ELISA was much more sensitive than gG4-12-mer ELISA.

Modèles de gestion des ressources forestières du massif ...

International Development Research Centre (IDRC) Digital Library (Canada)

Expérimentation Participative et Adaptative de Modèles de Gestion des Ressources Forestières dans la Chaine Montagneuse de l'Atlas (Algérie, Maroc, Tunisie) : rapport final (17 mars 2009 au 18 septembre 2012). Download PDF. Reports. Unité de transformation de cire d'abeille (Commune de M'Sara). Download PDF ...

: tous les projets | Page 253 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Au Sahel, la sécheresse et la piètre fertilité des sols limitent grandement le rendement des cultures. Date de début : 1 mars 2011. End Date: 1 septembre 2014. Sujet: FOOD CROPS, SOIL FERTILITY, FERTILIZERS, FERTILIZING, RAIN FED FARMING, WATER MANAGEMENT, CROP YIELD, Food security. Région: Burkina ...

Utilisation du partographe modifie de l'oms par les sages-femmes ...

African Journals Online (AJOL)

) de l'OMS par les sages-femmes de Lomé et leur position face à cet outil de surveillance du travail. Matériel et méthode : Il s'agit d'une étude prospective, transversale descriptive, menée du 01er juillet au 30 septembre 2011 (soit une période ...

: tous les projets | Page 547 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

La mondialisation et la libéralisation du commerce ont amené de nombreux pays en développement à adopter des réformes axées sur le marché. Date de début : 13 septembre 2006. End Date: 29 janvier 2009. Sujet: ECONOMIC REFORM, TRADE LIBERALIZATION, ECONOMIC LEGISLATION, SOCIAL LEGISLATION, ...

75 FR 16492 - Agency Information Collection Activities: Form G-28, and Form G-28I, Revision of an Existing...

Science.gov (United States)

2010-04-01

... DEPARTMENT OF HOMELAND SECURITY U.S. Citizenship and Immigration Services Agency Information... Attorney. OMB Control No. 1615-0105. The Department of Homeland Security, U.S. Citizenship and Immigration... of Homeland Security sponsoring the collection: Form G-28, and Form G-28I. U.S. Citizenship and...

The Lin28/let-7 axis regulates glucose metabolism

Science.gov (United States)

Zhu, Hao; Shyh-Chang, Ng; Segrè, Ayellet V.; Shinoda, Gen; Shah, Samar P.; Einhorn, William S.; Takeuchi, Ayumu; Engreitz, Jesse M.; Hagan, John P.; Kharas, Michael G; Urbach, Achia; Thornton, James E.; Triboulet, Robinson; Gregory, Richard I.; Altshuler, David; Daley, George Q.

2012-01-01

SUMMARY The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/b promote malignancy by blocking let-7 biogenesis. In studies of the Lin28/let-7 pathway, we discovered unexpected roles in regulating metabolism. When overexpressed in mice, both Lin28a and LIN28B promoted an insulin-sensitized state that resisted high fat diet-induced diabetes, whereas muscle-specific loss of Lin28a and overexpression of let-7 resulted in insulin resistance and impaired glucose tolerance. These phenomena occurred in part through let-7-mediated repression of multiple components of the insulin-PI3K-mTOR pathway, including IGF1R, INSR, and IRS2. The mTOR inhibitor rapamycin abrogated the enhanced glucose uptake and insulin-sensitivity conferred by Lin28a in vitro and in vivo. In addition, we found that let-7 targets were enriched for genes that contain SNPs associated with type 2 diabetes and fasting glucose in human genome-wide association studies. These data establish the Lin28/let-7 pathway as a central regulator of mammalian glucose metabolism. PMID:21962509

7 CFR 28.1 - Meaning of words.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Meaning of words. 28.1 Section 28.1 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... of words. Words used in this part in the singular form shall be deemed to import the plural, and vice...

Juggling with the norms

DEFF Research Database (Denmark)

Hahonou, Eric Komlavi

2015-01-01

The chapter investigates the inhospitality of Nigerien hospitals. Based on participant observation with the National Hospital of Niamey, the author describes the daily functioning of the emergency services. He points out the crucial role played by the patients' attendants in oiling the functionin...... of health facilities and the provision of care. The article explores how medical staff interact with patients and how they both contribute in producing the practical norms that shape the functioning of the emergency service....

Inhibition of West Nile virus by calbindin-D28k.

Directory of Open Access Journals (Sweden)

Venkatraman Siddharthan

Full Text Available Evidence indicates that West Nile virus (WNV employs Ca(2+ influx for its replication. Moreover, calcium buffer proteins, such as calbindin D28k (CB-D28k, may play an important role mitigating cellular destruction due to disease processes, and more specifically, in some neurological diseases. We addressed the hypothesis that CB-D28k inhibits WNV replication in cell culture and infected rodents. WNV envelope immunoreactivity (ir was not readily co-localized with CB-D28k ir in WNV-infected Vero 76 or motor neuron-like NSC34 cells that were either stably or transiently transfected with plasmids coding for CB-D28k gene. This was confirmed in cultured cells fixed on glass coverslips and by flow cytometry. Moreover, WNV infectious titers were reduced in CB-D28k-transfected cells. As in cell culture studies, WNV env ir was not co-localized with CB-D28k ir in the cortex of an infected WNV hamster, or in the hippocampus of an infected mouse. Motor neurons in the spinal cord typically do not express CB-D28k and are susceptible to WNV infection. Yet, CB-D28k was detected in the surviving motor neurons after the initial phase of WNV infection in hamsters. These data suggested that induction of CB-D28k elicit a neuroprotective response to WNV infection.

VP24-Karyopherin Alpha Binding Affinities Differ between Ebolavirus Species, Influencing Interferon Inhibition and VP24 Stability.

Science.gov (United States)

Schwarz, Toni M; Edwards, Megan R; Diederichs, Audrey; Alinger, Joshua B; Leung, Daisy W; Amarasinghe, Gaya K; Basler, Christopher F

2017-02-15

Zaire ebolavirus (EBOV), Bundibugyo ebolavirus (BDBV), and Reston ebolavirus (RESTV) belong to the same genus but exhibit different virulence properties. VP24 protein, a structural protein present in all family members, blocks interferon (IFN) signaling and likely contributes to virulence. Inhibition of IFN signaling by EBOV VP24 (eVP24) involves its interaction with the NPI-1 subfamily of karyopherin alpha (KPNA) nuclear transporters. Here, we evaluated eVP24, BDBV VP24 (bVP24), and RESTV VP24 (rVP24) interactions with three NPI-1 subfamily KPNAs (KPNA1, KPNA5, and KPNA6). Using purified proteins, we demonstrated that each VP24 binds to each of the three NPI-1 KPNAs. bVP24, however, exhibited approximately 10-fold-lower KPNA binding affinity than either eVP24 or rVP24. Cell-based assays also indicate that bVP24 exhibits decreased KPNA interaction, decreased suppression of IFN induced gene expression, and a decreased half-life in transfected cells compared to eVP24 or rVP24. Amino acid sequence alignments between bVP24 and eVP24 also identified residues within and surrounding the previously defined eVP24-KPNA5 binding interface that decrease eVP24-KPNA affinity or bVP24-KPNA affinity. VP24 mutations that lead to reduced KPNA binding affinity also decrease IFN inhibition and shorten VP24 half-lives. These data identify novel functional differences in VP24-KPNA interaction and reveal a novel impact of the VP24-KPNA interaction on VP24 stability. The interaction of Ebola virus (EBOV) VP24 protein with host karyopherin alpha (KPNA) proteins blocks type I interferon (IFN) signaling, which is a central component of the host innate immune response to viral infection. Here, we quantitatively compared the interactions of VP24 proteins from EBOV and two members of the Ebolavirus genus, Bundibugyo virus (BDBV) and Reston virus (RESTV). The data reveal lower binding affinity of the BDBV VP24 (bVP24) for KPNAs and demonstrate that the interaction with KPNA modulates inhibition

24. ATSR congress - Proceedings; 24e congres ATSR - Recueil des conferences

Energy Technology Data Exchange (ETDEWEB)

NONE

2008-06-15

-G. Mozziconacci); 18 - experience feedback after 4 years of implementation of diagnostic reference levels (A. Talbot); 19 - exposure levels at the dental office (J-M. Ariscon); 20 - implementation of the zoning by-law at Cadarache centre, methodology and first experience feedbacks (M. Juanola, S. Bontemps) 21 - cleansing techniques: radiological survey of a contaminated site (D. Dubot); 22 - Simulation of a work site accident (B. Carrez); 23 - neutron dosimetry developments, automatic trace detection system (M. Million); 24 - The new IRSN's radio-photoluminescent dosemeter (P. Fraboulet); 25 - Intercomparison of neutron dosemeters (M. Roig, P. Esteve); 26 - continuous improvement of workers radiation protection: training and certification (A. Bontemps); 27 - sources management (T. Juhel); 28 - Poster presentation: training of the employees of Cadarache radiation protection service to emergency exposure (M. Juanola)

28 CFR 68.24 - Use of depositions at hearings.

Science.gov (United States)

2010-07-01

... circumstances exist to make it desirable, in the interest of justice, and with due regard to the importance of...) Objections to the competency of a witness or to the competency, relevancy, or materiality of testimony are...

22 CFR 92.28 - Signature of affiant on affidavit.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Signature of affiant on affidavit. 92.28 Section 92.28 Foreign Relations DEPARTMENT OF STATE LEGAL AND RELATED SERVICES NOTARIAL AND RELATED SERVICES Specific Notarial Acts § 92.28 Signature of affiant on affidavit. The signature of the affiant is...

48 CFR 53.301-28 - Affidavit of Individual Surety.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Affidavit of Individual Surety. 53.301-28 Section 53.301-28 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Illustrations of Forms 53.301-28 Affidavit of Individual Surety. ER22MY03...

27 CFR 28.245 - Shipment to foreign-trade zone.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Shipment to foreign-trade zone. 28.245 Section 28.245 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Consignment § 28.245 Shipment to foreign-trade zone. Where distilled spirits (including specially denatured...

Synthesis of [64Cu]DOTA-ADIBON3-Ala-PEG28-A20FMDV2 via copper-free click chemistry for PET imaging of integrin αvβ6

International Nuclear Information System (INIS)

Drishty Satpati; Nadine Bauer; Hausner, S.H.

2014-01-01

Catalyst-free click reactions are effective chemical tools for synthesis of radiometal-based radiopharmaceuticals offering advantages towards preparation of non-toxic agents with high specific activity. In the present study the radiotracer [ 64 Cu]DOTA-ADIBON 3 -Ala-PEG 28 -A20FMDV2, [ 64 Cu]3, was synthesized for positron emission tomography imaging of integrin α v β 6 expressing tumors via a strain-promoted click reaction using both a 'pre-click' and 'post-click' approaches. The radiotracer, prepared in >99 % radiochemical yield, was evaluated in vitro (64.6 ± 2.8 % binding to α v β 6 -positive cells vs. v β 6 -negative cells) and in vivo (α v β 6 -positive tumor uptake: 1.52 ± 0.16 % ID/g, 24 h p.i.). While the high initial renal uptake (76.2 ± 10.7 % ID/g at 1 h p.i.) was comparable to a previously reported radiotracer, [ 64 Cu]DOTA-PEG 28 -A20FMDV2, [ 64 Cu]3 showed notably improved renal clearance (11.3 ± 2.5 % ID/g at 24 h p.i.). Thus, the introduction of a chelator-strained alkyne system resulted in improved pharmacokinetics for the present radiotracer, highlighting the attractive prospects of strain-promoted click-based preparations in the construction of radiometalated bioconjugates for targeted molecular imaging and therapy. (author)

Resonant nuclear reaction 23Mg (p,γ) 24Al in strongly screening magnetized neutron star crust

Science.gov (United States)

Liu, Jing-Jing; Liu, Dong-Mei

2017-12-01

Based on the relativistic theory of superstrong magnetic fields (SMF), by using three models those of Lai (LD), Fushiki (FGP), and our own (LJ), we investigate the influence of SMFs due to strong electron screening (SES) on the nuclear reaction 23Mg (p,γ) 24Al in magnetars. In a relatively low density environment (e.g., ρ 7102), our reaction rates can be 1.58 times and about three orders of magnitude larger than those of FGP and LD, respectively (B 12, ρ 7 are in units of 1012G, 107g cm-3). The significant increase of strong screening rate can imply that more 23Mg will escape from the Ne-Na cycle due to SES in a SMF. As a consequence, the next reaction, 24Al (β+, ν) 24Mg, will produce more 24Mg to participate in the Mg-Al cycle. Thus, it may lead to synthesis of a large amount of A>20 nuclides in magnetars. Supported by National Natural Science Foundation of China (11565020), the Counterpart Foundation of Sanya (2016PT43), the Special Foundation of Science and Technology Cooperation for Advanced Academy and Regional of Sanya (2016YD28), the Scientific Research Starting Foundation for 515 Talented Project of Hainan Tropical Ocean University (RHDRC201701) and the Natural Science Foundation of Hainan Province (114012)

7 CFR 56.28 - Types of service.

Science.gov (United States)

2010-01-01

... grader or quality assurance inspector as provided in § 56.39. (c) Temporary grading service. This type of... under the supervision of a grader or quality assurance inspector as provided in § 56.39. (d) Auditing... 7 Agriculture 3 2010-01-01 2010-01-01 false Types of service. 56.28 Section 56.28 Agriculture...

VP24-Karyopherin Alpha Binding Affinities Differ between Ebolavirus Species, Influencing Interferon Inhibition and VP24 Stability

Energy Technology Data Exchange (ETDEWEB)

Schwarz, Toni M.; Edwards, Megan R.; Diederichs, Audrey; Alinger, Joshua B.; Leung, Daisy W.; Amarasinghe, Gaya K.; Basler, Christopher F.; Lyles, Douglas S.

2016-12-14

Zaire ebolavirus(EBOV),Bundibugyo ebolavirus(BDBV), andReston ebolavirus(RESTV) belong to the same genus but exhibit different virulence properties. VP24 protein, a structural protein present in all family members, blocks interferon (IFN) signaling and likely contributes to virulence. Inhibition of IFN signaling by EBOV VP24 (eVP24) involves its interaction with the NPI-1 subfamily of karyopherin alpha (KPNA) nuclear transporters. Here, we evaluated eVP24, BDBV VP24 (bVP24), and RESTV VP24 (rVP24) interactions with three NPI-1 subfamily KPNAs (KPNA1, KPNA5, and KPNA6). Using purified proteins, we demonstrated that each VP24 binds to each of the three NPI-1 KPNAs. bVP24, however, exhibited approximately 10-fold-lower KPNA binding affinity than either eVP24 or rVP24. Cell-based assays also indicate that bVP24 exhibits decreased KPNA interaction, decreased suppression of IFN induced gene expression, and a decreased half-life in transfected cells compared to eVP24 or rVP24. Amino acid sequence alignments between bVP24 and eVP24 also identified residues within and surrounding the previously defined eVP24-KPNA5 binding interface that decrease eVP24-KPNA affinity or bVP24-KPNA affinity. VP24 mutations that lead to reduced KPNA binding affinity also decrease IFN inhibition and shorten VP24 half-lives. These data identify novel functional differences in VP24-KPNA interaction and reveal a novel impact of the VP24-KPNA interaction on VP24 stability.

IMPORTANCEThe interaction of Ebola virus (EBOV) VP24 protein with host karyopherin alpha (KPNA) proteins blocks type I interferon (IFN) signaling, which is a central component of the host innate immune response to viral infection. Here, we quantitatively compared the

27 CFR 28.295 - Exception for export of beer.

Science.gov (United States)

2010-04-01

... beer. 28.295 Section 28.295 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Alternate Procedures § 28.295 Exception for export of beer. The provisions of this subpart do not apply in the case of beer when the exporter or claimant obtains proof of exportation other than certification...

RBS using {sup 28}Si beams

Energy Technology Data Exchange (ETDEWEB)

Ophel, T.R. [Australian National Univ., Canberra, ACT (Australia); Mitchell, I.V. [University of Western Ontario, London, ON (Canada). Dept. of Physics

1996-12-31

Measurements of RBS using {sup 28}Si beams have been made to evaluate the enhancement of sensitivity that should obtain from kinematic suppression of silicon substrate scattering. Two detection methods were tried. Aside from a surface barrier detector, a magnetic spectrometer, instrumented with a multi-electrode gas focal plane detector, was used to indicate the resolution attainable with low energy {sup 28}Si ions. The results confirm that kinematically suppressed RBS does provide greatly improved sensitivity. 5 refs., 2 figs.

RBS using {sup 28}Si beams

Energy Technology Data Exchange (ETDEWEB)

Ophel, T R [Australian National Univ., Canberra, ACT (Australia); Mitchell, I V [University of Western Ontario, London, ON (Canada). Dept. of Physics

1997-12-31

Measurements of RBS using {sup 28}Si beams have been made to evaluate the enhancement of sensitivity that should obtain from kinematic suppression of silicon substrate scattering. Two detection methods were tried. Aside from a surface barrier detector, a magnetic spectrometer, instrumented with a multi-electrode gas focal plane detector, was used to indicate the resolution attainable with low energy {sup 28}Si ions. The results confirm that kinematically suppressed RBS does provide greatly improved sensitivity. 5 refs., 2 figs.

Association of modified NUTRIC score with 28-day mortality in critically ill patients.

Science.gov (United States)

Mukhopadhyay, Amartya; Henry, Jeyakumar; Ong, Venetia; Leong, Claudia Shu-Fen; Teh, Ai Ling; van Dam, Rob M; Kowitlawakul, Yanika

2017-08-01

For patients in the intensive care unit (ICU), nutritional risk assessment is often difficult. Traditional scoring systems cannot be used for patients who are sedated or unconscious since they are unable to provide information on their history of food intake and weight loss. We aim to validate the NUTRIC (NUTrition RIsk in Critically ill) score, an ICU-specific nutrition risk assessment tool in Asian patients. This was an observational study in the medical ICU of a university-affiliated tertiary hospital. We included all adult patients (≥18years) admitted between October 2013 and September 2014 who stayed for more than 24 hours in the ICU. Components of the modified NUTRIC (mNUTRIC) score, demographic details, body mass index (BMI), use of mechanical ventilation (MV), vasopressor drugs, and renal replacement therapy (RRT) were obtained from the ICU database. For patients on MV (maximum 12 days), we calculated the energy intake and nutritional adequacy (energy received ÷ energy recommended) from enteral or parenteral feeding data. Multivariable logistic regression analysis was used with 28-day mortality as the outcome of interest. 401 patients (62% male, mean age 60.0 ± 16.3 years, mean BMI 23.9 ± 6.2 kg/m 2 ) were included. In the univariate analysis, BMI, mNUTRIC score, MV, vasopressor drug, and RRT were associated with 28-day mortality. In the multivariable logistic regression analysis, mNUTRIC score (Odds ratio, OR 1.48, Confidence Interval, CI 1.25-1.74, p Nutritional adequacy was assessed in a subgroup of 273 (68%) patients who received MV for at least 48 hours. Median (IQR) nutritional adequacy was 0.44 (0.15-0.70). In patients with high mNUTRIC score (5-9), higher nutritional adequacy was associated with a lower predicted 28-day mortality; this was not observed in patients with low mNUTRIC (0-4) score (effect modification, p interaction nutritional adequacy may reduce the 28-day mortality in patients with a high mNUTRIC score. Copyright © 2016

Decay of a Jπ=36+ Resonance in the 24Mg+24Mg Reaction

International Nuclear Information System (INIS)

Salsac, M.-D.; Haas, F.; Courtin, S.

2005-01-01

For the 24 Mg+ 24 Mg reaction, striking narrow and correlated resonance structures have been observed previously in the excitation functions of the elastic and low-lying channels. In our study we have decided to focus on the resonance at E C M =45.7 MeV, which is known to have J π =36 + . Despite the very high excitation energy(∼60 MeV) in the 48 Cr composite system, this resonance has a narrow total width of 170 keV. To determine precisely which states in the inelastic 24 Mg channels carry away the resonance flux, an experiment, on the 24 Mg + 24 Mg reaction at energies On and OFF resonance, has been performed at the Legnaro Tandem accelerator using the Prisma fragment spectrometer associated with the CLARA γ array

Evaluation of the repeated-dose liver micronucleus assay using 2,4-dinitrotoluene: a report of a collaborative study by CSGMT/JEMS.MMS.

Science.gov (United States)

Maeda, Akihisa; Tsuchiyama, Hiromi; Asaoka, Yoshiji; Hirakata, Mikito; Miyoshi, Tomoya; Oshida, Keiyu; Miyamoto, Yohei

2015-03-01

The liver micronucleus assay using young adult rats has the potential to detect liver carcinogens by repeated dosing, and could be expected to be integrated into repeated-dose toxicity studies using a hepatocyte isolation method without the traditional in situ collagenase perfusion. In this study, to assess the performance of the repeated-dose liver micronucleus assay, 2,4-dinitrotoluene (DNT), which is a rodent liver carcinogen, was administered orally to male rats at doses of 50, 100 and 200 mg/kg/day once daily for 14 or 28 consecutive days, and the frequencies of micronucleated hepatocytes (MNHEPs) and micronucleated immature erythrocytes (MNIMEs) were examined. Significant increases in the MNHEPs were observed at 50 mg/kg/day or more in the 14-day treatment, and 50 and 100 mg/kg/day in the 28-day treatment. These increases were dependent on both the dose and the number of administrations, which indicates the possibility that the MNHEPs accumulate as a result of repeated dosing. In contrast, no increase in the MNIMEs was observed. In conclusion, the repeated-dose liver micronucleus assay using young adult rats is sufficiently sensitive to detect the genotoxicity of 2,4-DNT at a low dose.

Agroforesterie et alimentation des moutons au Mali | CRDI - Centre ...

International Development Research Centre (IDRC) Digital Library (Canada)

Review of pasture and fodder production and productivity for small ruminants in the Sahel. 53216. Rapports. Accroître la sécurité alimentaire en associant étroitement élevage, arbres et cultures par la pratique de l'agroforesterie au Mali : rapport technique final (1er mars 2011 - 1er septembre 2014). Téléchargez le PDF.

Panafrican Research Agenda on the Integration of ICTs in Education ...

International Development Research Centre (IDRC) Digital Library (Canada)

The Pan African Research Agenda aims to better understand how ICTs can improve the quality of African education from the primary to the tertiary level. This project will set ... Rapport de l'Atelier de formation sur l'intégration pédagogique des TIC, 6 et 7 septembre 2007 au Campus numérique francophone de Bamako, Mali.

Brazil : tous les projets | Page 10 | CRDI - Centre de recherches ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le Centro de Tecnologia e Sociedade (CTS - centre pour la technologie et la société) fait partie de la Faculté de droit de la Fundação Getulio Vargas à Rio de Janeiro. Date de début : 23 mars 2006. End Date: 11 septembre 2007. Sujet: CULTURAL INDUSTRY, INFORMATION TECHNOLOGY, INFORMATION SERVICES, ...

Nigeria : tous les projets | Page 4 | CRDI - Centre de recherches ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le Centro de Tecnologia e Sociedade (CTS - centre pour la technologie et la société) fait partie de la Faculté de droit de la Fundação Getulio Vargas à Rio de Janeiro. Date de début : 23 mars 2006. End Date: 11 septembre 2007. Sujet: CULTURAL INDUSTRY, INFORMATION TECHNOLOGY, INFORMATION SERVICES, ...

Résultats de recherche | Page 438 | CRDI - Centre de recherches ...

International Development Research Centre (IDRC) Digital Library (Canada)

Il s'agit du cinquième ouvrage d'une collection qui en compte cinq et qui collige les résultats de recherches intensives sur les systèmes d'innovation nationaux dans les pays BRICS : le Brésil, la Russie, l'Inde, la Chine et l'Afrique du Sud. Publication Date. 27 septembre 2013. Livres ...

: tous les projets | Page 477 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Les traumatismes psychosociaux résultant du conflit armé en Colombie représentent un problème de santé sociale et mentale urgent qui doit faire l'objet d'une attention immédiate. Date de début : 17 septembre 2007. End Date: 15 juillet 2010. Sujet: CONFLICT RESOLUTION, SOCIAL ASPECTS, PSYCHOLOGICAL ...

: tous les projets | Page 129 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Bien souvent, les femmes et les jeunes ne profitent pas pleinement des retombées de la croissance et du développement en Afrique. Date de début : 29 juillet 2013. End Date: 30 septembre 2015 ... Région: India, Central Asia, Far East Asia, South Asia. Financement total : CA$ 7,600.00. Dimensions intersectorielles des ...

: tous les projets | Page 161 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Malgré la très forte croissance économique observée au Pérou, le marché du travail ne permet pas d'offrir de meilleurs emplois à tout le monde. Date de début : 4 septembre 2012. End Date: 4 octobre 2014. Sujet: OCCUPATIONAL STRUCTURE, LABOUR MARKET, ACCESS TO MARKETS, DISADVANTAGED GROUPS, ...

Nigeria : tous les projets | Page 5 | CRDI - Centre de recherches ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le Centro de Tecnologia e Sociedade (CTS - centre pour la technologie et la société) fait partie de la Faculté de droit de la Fundação Getulio Vargas à Rio de Janeiro. Date de début : 23 mars 2006. End Date: 11 septembre 2007. Sujet: CULTURAL INDUSTRY, INFORMATION TECHNOLOGY, INFORMATION SERVICES, ...

: tous les projets | Page 578 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Les modèles commerciaux libres proposent une façon différente d'échanger, dans le domaine de l'information, des connaissances et de la culture, ne reposant pas essentiellement sur les droits de propriété intellectuelle comme moteur ou comme source de revenus principale. Date de début : 14 septembre 2008.

The 24 victims of the Epinal radiotherapy accident

International Nuclear Information System (INIS)

Benderitter, M.; Francois, A.; Clairand, I.; Trompier, F.; Huet, C.; Bottelier-Depois, J.F.; Gourmelon, P.; Gorin, N.

2008-01-01

Full text: During the last 4 years, several incidents/accidents at radiotherapy department occurred in France. The accident at the Public General Hospital in Epinal is the more severe. It was classified level 6 on a 10 degree scale of the ASN/SFRO (Autorite de Surete Nucleaire/Societe Francaise de Radiotherapie Oncologique). This accident is linked to a succession of dysfunctions and human errors. IRSN was elected by the Health Ministry for the identification and medical management of the victims. Concerning the patients treated for their prostate cancer with conformational RT between 2004 and 2005, 24 patients were exposed to 28% excess of dose and suffer from severe late effects (rectitis, cystitis) ranged from grade II to grade IV, some of them suffer from huge dilapidation. Some innovative medical strategies were proposed to the more severe affected patients. A medical follow-up of these patients is actually on the way in parallel to the development of a new research program concerning the improvement of the knowledge and prediction of radiotherapy complications. (author)

24R,25-Dihydroxyvitamin D3 Protects against Articular Cartilage Damage following Anterior Cruciate Ligament Transection in Male Rats.

Directory of Open Access Journals (Sweden)

Barbara D Boyan

Full Text Available Osteoarthritis (OA in humans is associated with low circulating 25-hydroxyvitamin D3 [25(OHD3]. In vitamin D replete rats, radiolabeled 24R,25-dihydroxyvitamin D3 [24R,25(OH2D3] accumulates in articular cartilage following injection of [3H]-25(OHD3. Previously, we showed that 24R,25(OH2D3 blocks chondrocyte apoptosis via phospholipase D and p53, suggesting a role for 24R,25(OH2D3 in maintaining cartilage health. We examined the ability of 24R,25(OH2D3 to prevent degenerative changes in articular cartilage in an OA-like environment and the potential mechanisms involved. In vitro, rat articular chondrocytes were treated with IL-1β with and without 24R,25(OH2D3 or 1α,25(OH2D3. 24R,25(OH2D3 but not 1α,25(OH2D3 blocked the effects of IL-1β in a dose-dependent manner, and its effect was partially mediated through the TGF-β1 signaling pathway. In vivo, unilateral anterior cruciate ligament transections were performed in immunocompetent rats followed by intra-articular injections of 24R,25(OH2D3 or vehicle (t = 0, 7, 14, 21 days. Tissues were harvested on day 28. Joints treated with vehicle had changes typical of OA whereas joints treated with 24R,25(OH2D3 had less articular cartilage damage and levels of inflammatory mediators. These results indicate that 24R,25(OH2D3 protects against OA, and suggest that it may be a therapeutic approach for preventing trauma-induced osteoarthritis.

50 CFR 28.43 - Destruction of dogs and cats.

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Destruction of dogs and cats. 28.43 Section 28.43 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR... VIOLATIONS OF PARTS 25, 26, AND 27 Impoundment Procedures § 28.43 Destruction of dogs and cats. Dogs and cats...

27 CFR 28.290 - Receipt in foreign trade zone.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Receipt in foreign trade zone. 28.290 Section 28.290 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... in Foreign-Trade Zone § 28.290 Receipt in foreign trade zone. On receipt at the zone, the shipment...

Study of heavy ion fusion: application to the system 28Si + 28Si

International Nuclear Information System (INIS)

Plagnol, E.

1982-03-01

Study of the fusion reactions between medium mass range heavy ions (experiments on 56 Ni compound nucleus formed by the reaction 28 Si + 28 Si): - analysis of the properties of the compound nucleus de-excitation process: utilization of the evaporation model based on the Hauser-Fesbach statistical model; study of the evolution of the production cross sections of the evaporation residues as a function of the excitation energy and of the angular momentum; - analysis of the kinetics of the compound nucleus formation, with construction of a model describing the various observed regimes, as a function of energy, in the compound nucleus formation cross section: study of the properties of the rotating liquid drop and of the formation kinetics evolution of the nuclei under Coulomb and nuclear potentials, up to a minimal approach distance, sticking conditions, and development towards scission or equilibrium state (compound nucleus) [fr

Neurodevelopmental comorbidities and seizure control 24 months after a first unprovoked seizure in children.

Science.gov (United States)

Jason, Eva Åndell; Tomson, Torbjörn; Carlsson, Sofia; Tedroff, Kristina; Åmark, Per

2018-07-01

To follow children with newly diagnosed unprovoked seizures to determine (1) whether the prevalence of neurodevelopmental comorbidities and cerebral palsy (CP) changed after the initial seizure, and (2) the association between studied comorbidities and seizures 13-24 months after seizure onset or initiation of treatment. Analyses were based on 750 children (28 days-18 years) with a first unprovoked seizure (index) included in a population-based Incidence Registry in Stockholm between 2001 and 2006. The children were followed for two years and their medical records were examined for a priori defined neurodevelopmental/psychiatric comorbidities and CP and seizure frequency. Baseline information was collected from medical records from before, and up to six months after, the index seizure. Odds ratios (OR) of repeated seizures 13-24 months after the first seizure or after initiation of anti-epileptic drug treatment was calculated by logistic regression and adjusted for age and sex. At baseline, 32% of the children had neurodevelopmental/psychiatric comorbidities or CP compared to 35%, 24 months later. Children with such comorbidities more often experienced seizures 13-24 months after the index seizure (OR 2.87, CI 2.07-3.99) with the highest OR in those with CP or attention deficit hyperactivity disorder (ADHD). Children diagnosed at age neurodevelopmental comorbidities and CP in children with epilepsy tend to be present already at seizure onset and that such comorbidities are strong indicators of poor outcome regarding seizure control with or without treatment. Copyright © 2018 Elsevier B.V. All rights reserved.

Improvement of an enzyme-linked immunosorbent assay for equine herpesvirus type 4 by using a synthetic-peptide 24-mer repeat sequence of glycoprotein G as an antigen

Science.gov (United States)

BANNAI, Hiroshi; NEMOTO, Manabu; TSUJIMURA, Koji; YAMANAKA, Takashi; MAEDA, Ken; KONDO, Takashi

2015-01-01

To increase the sensitivity of an enzyme-linked immunosorbent assay (ELISA) for equine herpesvirus type 4 (EHV-4) that uses a 12-mer peptide of glycoprotein G (gG4-12-mer: MKNNPIYSEGSL) [4], we used a longer peptide consisting of a 24-mer repeat sequence (gG4-24-mer: MKNNPIYSEGSLMLNVQHDDSIHT) as an antigen. Sera of horses experimentally infected with EHV-4 reacted much more strongly to the gG4-24-mer peptide than to the gG4-12-mer peptide. We used peptide ELISAs to test paired sera from horses naturally infected with EHV-4 (n=40). gG4-24-mer ELISA detected 37 positive samples (92.5%), whereas gG4-12-mer ELISA detected only 28 (70.0%). gG4-24-mer ELISA was much more sensitive than gG4-12-mer ELISA. PMID:26424485

Histological analysis of effects of 24% EDTA gel for nonsurgical treatment of periodontal tissues.

Science.gov (United States)

de Vasconcellos, Luana Marotta Reis; Ricardo, Lucilene Hernandes; Balducci, Ivan; de Vasconcellos, Luis Gustavo Oliveira; Carvalho, Yasmin Rodarte

2006-12-01

The aim of this study was to investigate, by means of histological and histomorphometric analysis, the effects of 24% ethylenediaminetetraacetic acid (EDTA) gel in periodontal tissue when used in combination with conventional periodontal treatment. Periodontitis was induced in the 2nd upper left permanent molars of 45 male Wistar rats by means of ligature. After 5 weeks, this was removed and debridement was performed. The animals were then randomly divided into 3 groups; group 1: mechanical treatment, group 2: mechanical treatment and EDTA gel application for 2 min, and group 3: mechanical treatment and placebo gel application for 2 min. After the treatment, rinsing was done with 0.9% saline solution for 1 min in all cases, followed by root notching in the deepest part of the pocket. After 4, 10, and 28 days the animals were sacrificed. The averages obtained were evaluated by means of test two-way analysis of variance (ANOVA) and Tukey statistical tests (P 24% EDTA gel did not interfere with periodontal tissue repair when used in combination with conventional periodontal treatment.

Central collisions between 28Si nuclei at 12.4, 19.7 and 30.0 MeV per nucleon

International Nuclear Information System (INIS)

Meijer, R.J.

1989-01-01

The formation and decay of nuclei in central collisions of the 28 Si + 28 Si system at bombarding energies of 12.4, 19.7 and 30.0 MeV per nucleon is studied by analysis of the light particle (LP) spectra measured in coincidence with evaporation residues (ER) and measurements of the inclusive velocity distribution of ER's. From the last set of measurements a strong reduction of the ER cross section at increasing incident energy was observed and especially the relation to a possible vanishing fusion cross section is discussed. The coincidence measurements determines the LP pre-equilibrium contribution and the LP decay modes of highly excited systems. The ER's produced in fusion reactions between 28 Si nuclei were detected with a simple ionization chamber ΔE detector and a surface barrier E detector. For the LP detection multidetector systems consisting of CsI(TL) detectors were used. In this thesis the developments that have led to the construction of a CsI(TL) charged particle detector and of the Utrecht multidetector system, the experimental setup and the methods used in the acquisition, processing and analysis of the data, are described. The results of the heavy-ion velocity measurements are presented and conclusions are drawn about equilibrium and pre-equilibrium processes from the analysis. (H.W.). 124 refs.; 44 figs.; 24 tabs

Angular momentum effects in the fusion of "2"8Si+"2"8Si system

International Nuclear Information System (INIS)

Choudhary, Atul; Verma, Dalip Singh

2016-01-01

In the heavy ion fusion reactions the interaction potential plays an important role as it provides the characteristics like barrier height, barrier position and barrier width in the calculations of fusion cross section. This means different types of interaction potential gives different fusion cross sections or potential parameters are predicted w.r.t the experimental data. In the literature, number of formalism for the calculation of fusion cross sections assumes that the potential barrier position and width is independent of angular momentum (ℓ). However, all the three potential characteristics are ℓ-dependent and are used in the calculation the fusion cross section for a positive Q-value system, "2"8Si+"2"8Si (Q = 10.9 MeV) and is compared with the recently measured fusion cross section

Separation of reaction mechanisms at low energy. Study of the reactions: 27Al(d,p) 28Al, 24Mg(d,p) 25Mg, and 24Mg(d, α) 22Na

International Nuclear Information System (INIS)

Mermaz, M.

1966-06-01

The two sets of angular distributions of (d,p) reactions on Al and Mg, measured between 2 and 6 MeV, have given the possibility to test, in analysing the statistical fluctuations of cross-section, the validity of the separation of their mean values in two parts, one 'direct', another given by the statistical mechanism. With the same method of analysis we have studied excitation functions for several alpha groups of the reaction 24 Mg(d, α) 22 Na and given an evidence for an intermediate structure for the alpha channel leading to the 3. excited state of 22 Na. The angular distribution of the wide resonance at 15.9 MeV in 26 Al has been obtained. (author) [fr

28-homobrassinolide Protects Photosynthetic Machinery in Indian mustard Under High Temperature Stress

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Qazi Fariduddin

2014-03-01

Full Text Available High temperature is a serious threat to crop production. Brassinosteroids (BRs, a group of plant steroidal hormones, can reduce effects of abiotic stresses. The present study was aimed to study the potency of brassinosteroids on high temperature induced changes in Indian mustard (Brassica juncea L. for effects on growth, chlorophyll, photosynthesis, photosystem II, antioxidant system and proline. Surface sterilized seeds of Indian mustard were sown in pots, grown for 21 days and treated with double distilled water or 0.01 µM of 28-homobrassinolide. Treated plants, after 24 h, were exposed to 30°C or 40°C for 48 h. One set of plants were kept at ambient temperature, 25°C, as the control. Plants were harvested at 30 days stage of growth to assess the various parameters. Plants exposed to 40°C had a decline in growth, leaf water potential, chlorophyll, photosynthetic rate, and activities of carbonic anhydrase (E.C.4.2.1.1 and nitrate reductase (E.C.1.6.1.1. The 28-homobrassinolide alone improved growth and photosynthesis responses along with various enzymes activities. Treatment of plants with HBL prior to exposure to 40°C, partially reduced damage and completely controlled damage when exposure was to 30°C. Levels of the antioxidative enzymes catalase (E.C.1.11.1.6, peroxidase (E.C.1.11.1.7, and superoxide dismutase (E.C.1.15.1.1, and the level of proline increased in response to 30 or 40°C and were further enhanced in the presence of 28-homobrassinolide. Plants grown under high temperature had increased levels of H2O2; application of HBL before temperature treatment decreased H2O2 content compared to the control. Elevated levels of antioxidative enzymes and proline might be responsible for conferring tolerance to high temperature stress in Indian mustard and overcome the loss of productivity of the crop.

Exon: CBRC-CFAM-28-0013 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-CFAM-28-0013 ATGGCAGTCGCCATCGCcatcactatcctcactatcatcaccatcatcaccatcacctccatcaccatcatcaccaccatcacca...tcttcatcaccaccatcatcaccatcaccatcatcaccatcatcatcaccatcactatcatcaccaccaccatcaccatcatcaccaccaccatcaccaccgtcacca...tcatcatcatcaccatcatcatcaccatcactatcatcaccattattaccatcaccatcatcaccaccgtcaccaccatcaccatcttcatcaccaccatcatcaccatcacc...atcatcaccatcatcatcaccatcactatcatcaccattattaccatcaccatcatcaccaccaccatcaccaccgtcacc...atcaccatcatcaccatcatcatcaccatcactatcatcaccaccatcaccatcatcatcaccaccatcaccatcatcatcaccaccatcatcaccatcacca

CD28 co-stimulation down regulates Th17 development.

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Salim Bouguermouh

Full Text Available Th17 cells are implicated in host defence and autoimmune diseases. CD28/B7 co-stimulation is involved in the induction and progression of autoimmune diseases, but its role in controlling murine Th17 cell fate remains to be clarified. We here report that soluble anti-CD28 mAb suppressed the differentiation of anti-CD3-stimulated naïve CD4(+ T cells into IL-17-producing cells. CD28 co-stimulation reduced the frequency of proliferating cells that produce IL-17. We provide evidence for an IL-2 and IFN-gamma-dependent mechanism of CD28-mediated IL-17 suppression. CD28 blockade of Th17 development was correlated with a decrease rather than an increase in the percentage of Foxp3(+ T cells. In APC/T cell co-cultures, mature dendritic cells (DC were less efficient than immature DC in their ability to support Th17 cell differentiation, while CTLA4-Ig, an agent blocking CD28/B7 and CTLA4/B7 interactions, facilitated both murine and human Th17 differentiation. This study identifies the importance of B7 co-stimulatory molecules in the negative regulation of Th17 development. These unexpected results caution targeting the CD28/B7 pathways in the treatment of human autoimmune diseases.

Fusion evaporation-residue cross sections for 28Si+40Ca at E(28Si)=309, 397, and 452 MeV

International Nuclear Information System (INIS)

Vineyard, M.F.; Bauer, J.S.; Crum, J.F.; Gosdin, C.H.; Trotter, R.S.; Kovar, D.G.; Beck, C.; Henderson, D.J.; Janssens, R.V.F.; Wilkins, B.D.; Maguire, C.F.; Mateja, J.F.; Prosser, F.W.; Stephans, G.S.F.

1992-01-01

Velocity distributions of mass-identified evaporation residues produced in the 28 Si+ 40 Ca reaction have been measured at bombarding energies of 309, 397, and 452 MeV using time-of-flight techniques. These distributions were used to identify evaporation residues and to separate the complete-fusion and incomplete-fusion components. Angular distributions and upper limits for the total evaporation-residue and complete-fusion evaporation-residue cross sections were extracted at all three bombarding energies. The complete-fusion evaporation-residue cross sections and the deduced critical angular momenta are compared with earlier measurements and the predictions of existing models. The ratios of the complete-fusion evaporation-residue cross section to the total evaporation-residue cross section, along with those measured for the 28 Si+ 12 C and 28 Si+ 28 Si systems at the same energies, support the entrance-channel mass-asymmetry dependence of the incomplete-fusion evaporation-residue process reported earlier

Epigenetic Regulation of Vitamin D 24-Hydroxylase/CYP24A1 in Human Prostate Cancer

Science.gov (United States)

Luo, Wei; Karpf, Adam R.; Deeb, Kristin K.; Muindi, Josephia R.; Morrison, Carl D.; Johnson, Candace S.; Trump, Donald L.

2010-01-01

Calcitriol, a regulator of calcium homeostasis with antitumor properties, is degraded by the product of the CYP24A1 gene which is downregulated in human prostate cancer by unknown mechanisms. We found that CYP24A1 expression is inversely correlated with promoter DNA methylation in prostate cancer cell lines. Treatment with the DNA methyltransferase inhibitor 5-aza-2′-deoxycytidine (DAC) activates CYP24A1 expression in prostate cancer cells. In vitro methylation of the CYP24A1 promoter represses its promoter activity. Furthermore, inhibition of histone deacetylases by trichostatin A (TSA) enhances the expression of CYP24A1 in prostate cancer cells. ChIP-qPCR reveals that specific histone modifications are associated with the CYP24A1 promoter region. Treatment with TSA increases H3K9ac and H3K4me2 and simultaneously decreases H3K9me2 at the CYP24A1 promoter. ChIP-qPCR assay reveals that treatment with DAC and TSA increases the recruitment of VDR to the CYP24A1 promoter. RT-PCR analysis of paired human prostate samples reveals that CYP24A1 expression is down-regulated in prostate malignant lesions compared to adjacent histologically benign lesions. Bisulfite pyrosequencing shows that CYP24A1 gene is hypermethylated in malignant lesions compared to matched benign lesions. Our findings indicate that repression of CYP24A1 gene expression in human prostate cancer cells is mediated in part by promoter DNA methylation and repressive histone modifications. PMID:20587525

Impact of Different Normality Thresholds for 24-hour ABPM at the Primary Health Care Level

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Guilherme Brasil Grezzana

Full Text Available Abstract Background: Hypertension is an important risk factor for cardiovascular outcomes. Primary health care (PHC physicians should be prepared to act appropriately in the prevention of cardiovascular risk factors. However, the rates of patients with control of blood pressure (BP remain low. The impact of the reclassification of high BP by 24-hour ambulatory BP monitoring (ABPM can lead to different medical decisions in PHC. Objective: To evaluate the agreement between the BP measured by a conventional method by PHC physicians and by 24-hour ABPM, considering different BP normal thresholds for the 24-hour ABPM according to the V Brazilian ABPM Guidelines and the European Society of Hypertension Guidelines. Methods: A cross-sectional study including 569 hypertensive patients. The BP was initially measured by the PHC physicians and, later, by 24-hour ABPM. The BP measurements were obtained independently between the two methods. The therapeutic targets for the conventional BP followed the guidelines by the Eighth Joint National Committee (JNC 8, the V ABPM Brazilian Guidelines, and the 2013 European Hypertension Guidelines. Results: There was an accuracy of 54.8% (95% confidence interval [95%CI] 0.51 - 0.58% for the BP measured with the conventional method when compared with the 24-hour ABPM, with a sensitivity of 85% (95%CI 80.8 - 88.6%, specificity of 31.9% (95%CI 28.7 - 34.7%, and kappa value of 0.155, when considering the European Hypertension Guidelines. When using more stringent thresholds to characterize the BP as "normal" by ABPM, the accuracy was 45% (95%CI 0.41 - 0.47% for conventional measurement when compared with 24-hour ABPM, with a sensitivity of 86.7% (95%CI 0.81 - 0.91%, specificity of 29% (95%CI 0.26 - 0.30%, and kappa value of 0.103. Conclusion: The BP measurements obtained by PHC physicians showed low accuracy when compared with those obtained by 24-hour ABPM, regardless of the threshold set by the different guidelines.

Progress of interleukin-24 study

International Nuclear Information System (INIS)

Liu Yongzhe; Jin Shunzi

2007-01-01

Interteukin-24 (11-24)is a member of interleukin-10 family. Besides its character as a cytokine, IL-24 could induce apoptosis of different kinds of tumor cells without any harmful effects to normal cells. IL-24 could both promote bystander anti-tumor effect, inhibit tumor growth and angiogenesis in animal models. It also has effects of radiosensitization and immunoregulation. (authors)

7 CFR 28.954 - Costs of submitting samples.

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2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Costs of submitting samples. 28.954 Section 28.954 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER...

Study of the excited states of 28Si using the 27Al(p,γ)28Si radiative capture

International Nuclear Information System (INIS)

Dalmas, Jean.

1974-01-01

The gamma decay of 28 Si levels excited in the 27 Al(p,γ) 28 Si reaction has been investigated in the energy range Esub(p) 3 classification. A part from the K=0 + rotational band based on the ground state, the SU 3 previsions are not substantiated, but can not definitely rejected, and a few experiment are suggested. On the other band, many results are consistent with the shell model calculations [fr

24. International Conference on Atomic Collisions in Solids ICACS-24

International Nuclear Information System (INIS)

2010-01-01

This Book contains the abstracts of invited and contributed talks submitted for presentation at the 24 th International Conference on Atomic Collisions in Solids - ICACS-24. Out of nearly 200 submitted abstracts the International Programme Committee selected 46 oral and 89 poster contributions. Furthermore, 15 plenary invited lectures and the honorary Lindhard lecture are included in the scientific program. An additional tutorial day with 4 tutorial lectures is organised on Sunday prior to the Conference.

Fasting for 24 hours heightens reward from food and food-related cues.

Science.gov (United States)

Cameron, Jameason D; Goldfield, Gary S; Finlayson, Graham; Blundell, John E; Doucet, Eric

2014-01-01

We examined the impact of a 24 hour complete fast (vs. fed state) on two measures of food reward: 1) 'wanting', as measured by response to food images and by the relative-reinforcing value of food (RRV), and 2) 'liking', as measured by response to food images and the hedonic evaluation of foods consumed. Utilizing a randomized crossover design, 15 subjects (9 male; 6 female) aged 28.6±4.5 yrs with body mass index 25.3±1.4 kg/m(2) were randomized and counterbalanced to normal feeding (FED) and 24-hour fast (FASTED) conditions. Trait characteristics were measured with the Three Factor Eating Questionnaire. Two computer tasks measured food reward: 1) RRV progressive ratio task, 2) explicit 'liking' and 'wanting' (Leeds Food Preference Questionnaire, LFPQ). Also measured were ad libitum energy intake (EI; buffet) and food 'liking' (visual analogue scale) of personalized stimuli. There were no significant anthropometric changes between conditions. Appetite scores, hedonic ratings of 'liking', and ad libitum EI all significantly increased under the FASTED condition (pFASTED condition there were significant increases in the RRV of snack foods; similarly, explicit 'wanting' and 'liking' significantly increased for all food categories. 'Liking' of sweet foods remained high across-meals under FASTED, but savory foods decreased in hedonic saliency. Relative to a fed state, we observed an increase in hedonic ratings of food, the rewarding value of food, and food intake after a 24 hr fast. Alliesthesia to food and food cues is suggested by heightened hedonic ratings under the FASTED condition relative to FED.

48 CFR 28.203 - Acceptability of individual sureties.

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2010-10-01

... individual sureties. 28.203 Section 28.203 Federal Acquisition Regulations System FEDERAL ACQUISITION... Acceptability of individual sureties. (a) An individual surety is acceptable for all types of bonds except position schedule bonds. The contracting officer shall determine the acceptability of individuals proposed...

7 CFR 28.413 - Middling Light Spotted Color.

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2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Middling Light Spotted Color. 28.413 Section 28.413... Spotted Color. Middling Light Spotted Color is color which in spot or color, or both, is between Middling Color and Middling Spotted Color. ...

32 CFR 2400.28 - Dissemination of classified information.

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2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Dissemination of classified information. 2400.28... SECURITY PROGRAM Safeguarding § 2400.28 Dissemination of classified information. Heads of OSTP offices... originating official may prescribe specific restrictions on dissemination of classified information when...

28 CFR 550.54 - Incentives for RDAP participation.

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2010-07-01

... Section 550.54 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT.... (i) Limited financial awards, based upon the inmate's achievement/completion of program phases. (ii... financial program responsibility obligations (see 28 CFR part 545) and GED responsibilities (see 28 CFR part...

Pleural Effusion in Spinal Deformity Correction Surgery- A Report of 28 Cases in a Single Center.

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Weiqiang Liang

Full Text Available To analyze the occurrence, risk factors, treatment and prognosis of postoperative pleural effusion after spinal deformity correction surgery.The clinical and imaging data of 3325 patients undergoing spinal deformity correction were collected from the database of our hospital. We analyzed the therapeutic process of the 28 patients who had postoperative pleural effusion, and we identified the potential risk factors using logistic regression.Among the 28 patients with postoperative pleural effusion, 24 (85.7% suffered from hemothorax, 2 (7.1% from chylothorax, and 2 (7.1% from subarachnoid-pleural fistula. The pleural effusion occurred on the convex side in 19 patients (67.9%, on the concave side in 4 patients (14.3%, and on both sides in 4 patients (14.3%. One patient with left hemothorax was diagnosed with kyphosis. The treatment included conservative clinical observation for 5 patients and chest tube drainage for 23 patients. One patient also underwent thoracic duct ligation and pleurodesis. All of these treatments were successful. Logistic regression analysis showed that adult patients(≥18 years old, congenital scoliosis, osteotomy and thoracoplasty were risk factors for postoperative pleural effusion in spinal deformity correction surgery.The incidence of postoperative pleural effusion in spinal deformity correction surgery was approximately 0.84% (28/3325, and hemothorax was the most common type. Chest tube drainage treatment was usually successful, and the prognosis was good. Adult patients(≥18 years old, congenital scoliosis, and had undergone osteotomy or surgery with thoracoplasty were more likely to suffer from postoperative pleural effusion.

The frequency of using different types of pacifier and bottle nipple among 1-24 months old children

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Hamidreza Poureslami

2016-03-01

Full Text Available BACKGROUND AND AIM: Sucking of some types of a pacifier may be a risk factor for mal-development of orofacial structures and malocclusion. This study assessed the prevalence of using of different types of pacifier and bottle nipple among 1-24 months old children in Kerman, Iran. METHODS: In this cross-sectional study, a total of 300 mothers interviewed at 20 specialized private pediatric offices in Kerman. The mothers had 1-24 months old children. A checklist includes items about pacifier sucking, bottle feeding habits, as well as mothers’ ability to recognize different kinds of available pacifier and bottle nipple was used. RESULTS: The rate of pacifier-sucking was 37.3%, and use of bottle feeding was 42.3%, and among of the users, 24.0 and 35.7% were used orthodontic (functional types of pacifier and bottle nipple respectively. However, only 28.7% of mothers had adequate ability to recognize orthodontic pacifier and bottle nipple. CONCLUSION: The rates of using orthodontic kind of pacifier and bottle nipple were low, and a few mothers had adequate ability to recognize their differences.

Development of an immunoassay for determination of 2,4-dichlorophenoxyacetic acid (2,4-D) based upon the recombinant Fab fragment of 2,4-D specific antibody

Science.gov (United States)

Nguyen, Van C.; Nguyen, Thi D. T.; Dau, Hung A.; Tham, Thu N.; Quyen, Dinh T.; Bachmman, Till; Schmid, Rolf D.

2001-09-01

To develop an immunoassay and further an immunosensor for 2,4-D based upon recombinant antibody, the Fab fragments of 2,4-D specific antibody were expressed in E. coli. Western blotting analysis of the periplasmic cell fractions shown that under the non-reducing condition only a single protein band at a molecular mass of 45-kDa, corresponding to the whole Fab fragment was detected. Antigen binding activity for 2,4-D was found only in the extract of cells bearing the 2,4-D plasmid. An immunoassay based on the competitive reaction of 2,4-D and enzyme tracer with 2,4-D Fab fragments immobilized on micro titer plates via rabbit anti-mouse IgC was developed. Using this assay, 2,4-D could be detected at concentration range of 0.5 (mu) g/1 to 10(mu) g/1. The center point of the 2,4-D test was found at a concentration of 5 (mu) g/l. The assay was applied for detection of 2,4-D in spiked orange samples, resulting in recovery rate of 90 percent. The immunoassay could be applied to monitor human exposure to 2,4-D from contamination in fruit samples.

7 CFR 28.421 - Good Middling Spotted Color.

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2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Good Middling Spotted Color. 28.421 Section 28.421 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... Color. Good Middling Spotted Color is color which is better than Strict Middling Spotted Color. ...

7 CFR 28.431 - Strict Middling Tinged Color.

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2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Strict Middling Tinged Color. 28.431 Section 28.431 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... Color. Strict Middling Tinged Color is color which is better than Middling Tinged Color. ...

49 CFR 28.149 - Program accessibility: Discrimination prohibited.

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2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Program accessibility: Discrimination prohibited... § 28.149 Program accessibility: Discrimination prohibited. Except as otherwise provided in § 28.150, no... otherwise be subjected to discrimination under any program or activity conducted by the Department. ...

Innovation - Vol 28 (2004)

African Journals Online (AJOL)

DOWNLOAD FULL TEXT Open Access DOWNLOAD FULL TEXT Subscription or Fee Access. Table of Contents. Articles. The development of libraries in Kenya · EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Japhet Otike, 1-8. http://dx.doi.org/10.4314/innovation.v28i1.26461 ...

7 CFR 1230.24 - State.

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2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false State. 1230.24 Section 1230.24 Agriculture... CONSUMER INFORMATION Pork Promotion, Research, and Consumer Information Order Definitions § 1230.24 State. State means each of the 50 States. ...

41 CFR 101-28.303 - Benefits provided by customer supply centers.

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2010-07-01

... customer supply centers. 101-28.303 Section 101-28.303 Public Contracts and Property Management Federal...-STORAGE AND DISTRIBUTION 28.3-Customer Supply Centers § 101-28.303 Benefits provided by customer supply centers. The customer supply centers (CSCs) provide the following: (a) Overall savings to the Federal...

7 CFR 322.28 - General requirements; restricted articles.

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2010-01-01

... 7 Agriculture 5 2010-01-01 2010-01-01 false General requirements; restricted articles. 322.28... EQUIPMENT Importation and Transit of Restricted Articles § 322.28 General requirements; restricted articles. (a) The following articles from any region are restricted articles: (1) Dead bees of any genus; (2...

The energy situation. September 2008; Conjoncture energetique. Septembre 2008

Energy Technology Data Exchange (ETDEWEB)

NONE

2008-07-01

Statistics are given on the energy and raw materials production and consumption levels in France in September 2008. Primary energy demand has increased for the petroleum products, stayed stable for the natural gas, decreased for the coal and the electric power. A special attention is given to the primary energy, the solid fuels, the petroleum products, the natural gas and the electric power. (A.L.B.)

Fusion evaporation residues and the distribution of reaction strength in 16O + 40Ca and 28Si + 28Si reactions

International Nuclear Information System (INIS)

Kolata, J.J.; Hinnefeld, J.; Kovar, D.G.

1985-01-01

In measurements performed previously at ANL, studying the two entrance channels 16 O + 40 Ca and 28 Si + 28 Si which form the same compound nucleus 56 Ni, it was found that at higher bombarding energies (E/sub Lab/ > 5-7 MeV/nucleon) the distributions of reaction strength was dramatically different. Although the total reaction cross section behaviors for the two entrance channels are similar, the total evaporation residue (ER) cross sections for 28 Si + 28 Si decrease rapidly with increasing bombarding energies and up to the highest energy studied show no evidence for incomplete fusion processes. For 16 O + 40 Ca the ER cross section remains constant at approximately 1 barn with increasing bombarding energy and shows evidence of increasing contributions from incomplete fusion. To better understand this apparent dependence on the mass asymmetry in the entrance channel, coincidence measurements between evaporation residue-like products and heavy ions on the opposite side of the beam were performed for the two systems at E/sub Lab/ = 8 MeV/nucleon

Shape coexistence in N = 28 isotones

International Nuclear Information System (INIS)

Saxena, G.; Kaushik, M.; Kumawat, M.; Jain, S.K.

2016-01-01

Shape coexistence is one of the important nuclear phenomenon which appears throughout the periodic chart from light mass nuclei to superheavy nuclei. The evolution of ground-state shapes in an isotopic or isotonic chain is governed by changes of the shell structure of single-nucleon orbitals. In recent past, evolution of shell structure guiding shape coexistence, has been observed in the N = 20 and N = 28 isotones around proton drip line. In this paper we have investigated shape coexistence phenomenon for N = 28 isotones in the vicinity of proton drip line using Relativistic Mean Field plus BCS approach

Association of IL28B SNPs rs12979860 and rs8099917 on Hepatitis C Virus-RNA Status in Donors/Recipients of Living Donor Liver Transplantation.

Directory of Open Access Journals (Sweden)

King-Wah Chiu

Full Text Available To investigate the effect of IL28B single nucleotide polymorphisms (SNPs (rs8099917 and rs12979860 in the donors and recipients on the outcome of Hepatitis C virus-RNA clearance after living donor liver transplantation (LDLT. The rs8099917 and rs12979860 genotypes in 50 donor and recipients pairs were explored on the pre-operative day (POD and post-operative day 30 (POD30. There was a significant difference in HCV-RNA clearance before (12%, 6/50 and after (48%, 24/50 liver transplantation (P < 0.001. The rs8099917 genotype TT was dominant in both the recipients (82%, 41/50 and donors (86%, 43/50, but had no significant effect on HCV-RNA clearance (87.5%, 21/24 and recurrence (76.9%, 20/26 after LDLT. One recipient was detected with genotype GG on POD, which changed to genotype GT on POD30. Prevalence of rs12979860 genotype CT was 98% (49/50 recipient and 92% (46/50 donor and prevalence of genotype CC was 2% (1/50 recipient and 8% (4/50 donor on POD and POD30, respectively. Of the 4 recipients with rs12979860 genotype CC on POD30, 3 recipients (12.5%, 3/24 exhibited HCV clearance and 1 experienced recurrence (3.9%, 1/26, however, this was not statistically significant. In conclusion, alterations in IL28B SNP genotype may occur after LDLT, leading to modifications in the host genome or donor proteome by HCV. This predicted mechanism will need to be investigated further.

Removal of 2,4-dichlorophenol and pentachlorophenol from waters by sorption using coal fly ash from a Portuguese thermal power plant

International Nuclear Information System (INIS)

Estevinho, Berta N.; Martins, Isabel; Ratola, Nuno; Alves, Arminda; Santos, Lucia

2007-01-01

Chlorophenols are one of the most important groups of priority pollutants, due to their high toxicity, mutagenicity and carcinogenicity. Although activated carbon has been the preferred choice for the removal of such pollutants from wastewaters, the search for cheaper alternative sorbents became common in the last years. Fly ash, a by-product from coal burning power plants, has a surface composition that may enable the sorption of specific organic compounds. Therefore, this feasibility study presents the optimization of the operating parameters of a fixed-bed column containing fly ash particles, percolated by aqueous solutions of 2,4-dichlorophenol (2,4-DCP) and pentachlorophenol (PCP) with concentrations of 1 and 100 μg/ml. Both chlorophenols were analysed by gas chromatography with electron capture detection (GC-ECD), after solid-phase microextraction (SPME), with limits of detection (LODs) of 7.28 μg/l for 2,4-DCP and 1.76 μg/l for PCP. Removal efficiencies above 99% were obtained for an initial concentration of 10 μg/ml of chlorophenols. Column saturation was achieved after 7 h of continuous operation for 2,4-DCP and 10 h for the PCP for feed levels of 10 μg/ml. Fly ash exhibited more affinity towards the sorption of PCP, in comparison to 2,4-DCP

AoS28D, a proline-Xaa carboxypeptidase secreted by Aspergillus oryzae.

Science.gov (United States)

Salamin, Karine; Eugster, Philippe J; Jousson, Olivier; Waridel, Patrice; Grouzmann, Eric; Monod, Michel

2017-05-01

Prolyl peptidases of the MEROPS S28 family are of particular interest because they are key enzymes in the digestion of proline-rich peptides. A BLAST analysis of the Aspergillus oryzae genome revealed sequences coding for four proteases of the S28 family. Three of these proteases, AoS28A, AoS28B, and AoS28C, were previously characterized as acidic prolyl endopeptidases. The fourth protease, AoS28D, showed high sequence divergence with other S28 proteases and belongs to a phylogenetically distinct cluster together with orthologous proteases from other Aspergillus species. The objective of the present paper was to characterize AoS28D protease in terms of substrate specificity and activity. AoS28D produced by gene overexpression in A. oryzae and in Pichia pastoris was a 70-kDa glycoprotein with a 10-kDa sugar moiety. In contrast with other S28 proteases, AoS28D did not hydrolyze internal Pro-Xaa bonds of several tested peptides. Similarly, to human lysosomal Pro-Xaa carboxypeptidase, AoS28D demonstrated selectivity for cleaving C-terminal Pro-Xaa bonds which are resistant to carboxypeptidases of the S10 family concomitantly secreted by A. oryzae. Therefore, AoS28D could act in synergy with these enzymes during sequential degradation of a peptide from its C-terminus.