WorldWideScience

Sample records for next-generation planet finder

  1. The science case of the CHEOPS planet finder for VLT

    NARCIS (Netherlands)

    Gratton, R.; Feldt, M.; Schmid, H.M.; Brandner, W.; Hippler, S.; Neuhauser, R.; Quirrenbach, A.; Desidera, S.; Turatto, M.; Stam, D.M.; Hasinger, G.; Turner, M.J.L.

    2004-01-01

    The CHEOPS Planet Finder is one of the proposed second generation instruments for the VLT. Its purpose is to image and characterize giant extrasolar planets in different phases of their evolution: young, warm planets as well as old, cold ones. Imaging the last ones is the most challenging task

  2. Terrestrial Planet Finder Coronagraph High Accuracy Optical Propagation, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The Terrestrial Planet Finder (TPF) project is considering several approaches to discovering planets orbiting stars far from earth and assessing their suitability to...

  3. HPF: The Habitable Zone Planet Finder at the Hobby-Eberly Telescope

    Science.gov (United States)

    Wright, Jason T.; Mahadevan, Suvrath; Hearty, Fred; Monson, Andy; Stefansson, Gudmundur; Ramsey, Larry; Ninan, Joe; Bender, Chad; Kaplan, Kyle; Roy, Arpita; Terrien, Ryan; Robertson, Paul; Halverson, Sam; Schwab, Christian; Kanodia, Shubham

    2018-01-01

    The Habitable Zone Planet Finder (HPF) is an ultra-stable NIR (ZYJ) high resolution echelle spectrograph on the 10-m Hobby-Eberly Telescope capable of 1-3 m/s Doppler velocimetry on nearby late M dwarfs (M4-M9). This precision is sufficient to detect terrestrial planets in the Habitable Zones of these relatively unexplored stars. Here we present its capabilities and early commissioning results.

  4. Terrestrial Planet Finder: Coda to 10 Years of Technology Development

    Science.gov (United States)

    Lawson, Peter R.

    2009-01-01

    The Terrestrial Planet Finder (TPF) was proposed as a mission concept to the 2000 Decadal Survey, and received a very high ranking amongst the major initiatives that were then reviewed. As proposed, it was a formation flying array of four 3-m class mid-infrared telescopes, linked together as an interferometer. Its science goal was to survey 150 nearby stars for the presence of Earth-like planets, to detect signs of life or habitability, and to enable revolutionary advances in high angular resolution astrophysics. The Decadal Survey Committee recommended that $200M be invested to advance TPF technology development in the Decade of 2000-2010. This paper presents the results of NASA's investment.

  5. Earth-based planet finders power up

    Science.gov (United States)

    Clery, Daniel

    2018-01-01

    NASA's Kepler spacecraft has racked up thousands of exoplanet discoveries since its launch in 2009, but before Kepler, the workhorses of exoplanet identification were ground-based instruments that measure tiny stellar wobbles caused by the gravity of an orbiting planet. They are now undergoing a quiet renaissance. The new generation of these devices may be precise enough to find a true Earth twin: a planet with the same mass as ours, orbiting a sunlike star once a year. That's something Kepler—sensitive to planet size, but not mass—can't do. Over the past few months, two new third-generation instruments have opened their eyes to the sky and nearly two dozen others are either under construction or have recently begun service.

  6. Automatic generation of gene finders for eukaryotic species

    DEFF Research Database (Denmark)

    Terkelsen, Kasper Munch; Krogh, A.

    2006-01-01

    and quality of reliable gene annotation grows. Results We present a procedure, Agene, that automatically generates a species-specific gene predictor from a set of reliable mRNA sequences and a genome. We apply a Hidden Markov model (HMM) that implements explicit length distribution modelling for all gene......Background The number of sequenced eukaryotic genomes is rapidly increasing. This means that over time it will be hard to keep supplying customised gene finders for each genome. This calls for procedures to automatically generate species-specific gene finders and to re-train them as the quantity...... structure blocks using acyclic discrete phase type distributions. The state structure of the each HMM is generated dynamically from an array of sub-models to include only gene features represented in the training set. Conclusion Acyclic discrete phase type distributions are well suited to model sequence...

  7. Detection of planets in extremely weak central perturbation microlensing events via next-generation ground-based surveys

    International Nuclear Information System (INIS)

    Chung, Sun-Ju; Lee, Chung-Uk; Koo, Jae-Rim

    2014-01-01

    Even though the recently discovered high-magnification event MOA-2010-BLG-311 had complete coverage over its peak, confident planet detection did not happen due to extremely weak central perturbations (EWCPs, fractional deviations of ≲ 2%). For confident detection of planets in EWCP events, it is necessary to have both high cadence monitoring and high photometric accuracy better than those of current follow-up observation systems. The next-generation ground-based observation project, Korea Microlensing Telescope Network (KMTNet), satisfies these conditions. We estimate the probability of occurrence of EWCP events with fractional deviations of ≤2% in high-magnification events and the efficiency of detecting planets in the EWCP events using the KMTNet. From this study, we find that the EWCP events occur with a frequency of >50% in the case of ≲ 100 M E planets with separations of 0.2 AU ≲ d ≲ 20 AU. We find that for main-sequence and sub-giant source stars, ≳ 1 M E planets in EWCP events with deviations ≤2% can be detected with frequency >50% in a certain range that changes with the planet mass. However, it is difficult to detect planets in EWCP events of bright stars like giant stars because it is easy for KMTNet to be saturated around the peak of the events because of its constant exposure time. EWCP events are caused by close, intermediate, and wide planetary systems with low-mass planets and close and wide planetary systems with massive planets. Therefore, we expect that a much greater variety of planetary systems than those already detected, which are mostly intermediate planetary systems, regardless of the planet mass, will be significantly detected in the near future.

  8. Linear Thermal Expansion Measurements of Lead Magnesium Niobate (PMN) Electroceramic Material for the Terrestrial Planet Finder Coronagraph

    Science.gov (United States)

    Karlmann, Paul B.; Halverson, Peter G.; Peters, Robert D.; Levine, Marie B.; VanBuren, David; Dudik, Matthew J.

    2005-01-01

    Linear thermal expansion measurements of nine samples of Lead Magnesium Niobate (PMN) electroceramic material were recently performed in support of NASA's Terrestrial Planet Finder Coronagraph (TPF-C) mission. The TPF-C mission is a visible light coronagraph designed to look at roughly 50 stars pre- selected as good candidates for possessing earth-like planets. Upon detection of an earth-like planet, TPF-C will analyze the visible-light signature of the planet's atmosphere for specific spectroscopic indicators that life may exist there. With this focus, the project's primary interest in PMN material is for use as a solid-state actuator for deformable mirrors or compensating optics. The nine test samples were machined from three distinct boules of PMN ceramic manufactured by Xinetics Inc. Thermal expansion measurements were performed in 2005 at NASA Jet Propulsion Laboratory (JPL) in their Cryogenic Dilatometer Facility. All measurements were performed in vacuum with sample temperature actively controlled over the range of 270K to 3 10K. Expansion and contraction of the test samples with temperature was measured using a JPL developed interferometric system capable of sub-nanometer accuracy. Presented in this paper is a discussion of the sample configuration, test facilities, test method, data analysis, test results, and future plans.

  9. The DLR AsteroidFinder for NEOs

    Science.gov (United States)

    Mottola, Stefano; Kuehrt, Ekkehard; Michaelis, Harald; Hoffmann, Harald; Spietz, Peter; Jansen, Frank; Thimo Grundmann, Jan; Hahn, Gerhard; Montenegro, Sergio; Findlay, Ross; Boerner, Anko; Messina, Gabriele; Behnke, Thomas; Tschentscher, Matthias; Scheibe, Karsten; Mertens, Volker; Heidecke, Ansgar

    Potential Earth-impacting asteroids that spend most of their time interior to Earth's orbit are extremely difficult to be observed from the ground and remain largely undetected. Firstly, they are mostly located at small solar elongations, where the sky brightness and their faintness due to the large phase angle prevents their discovery. Secondly, these objects tend to have very long synodic orbital periods, which makes observation opportunities rare and impact warning times short. Because of these limitations, even the advent of next generation ground-based asteroid surveys is not likely to radically improve the situation (Veres et al. Icarus 203, p472, 2009). On the other hand, a small satellite with a suitable design can observe close to the Sun and detect these objects efficiently against a dark sky background. For this reason, DLR, the German Aerospace Center, has selected AsteroidFinder as the first experiment to be launched under its new compact satellite national program. The primary goal of the mission is to detect and characterize Near Earth Objects (NEOs), with a particular focus on the population of objects completely contained within Earth's orbit (IEOs or Inner Earth Objects). Current dynamical models predict the existence of more than 1000 such objects down to a size of 100m, of which, due to the abovementioned observation difficulties, only 10 have been discovered to date. Benefitting from the vantage point of a Low Earth Orbit (LEO), AsteroidFinder makes use of a small optical telescope to scan those regions of the sky that are close to the Sun, and therefore beyond the reach of ground based observatories. By estimating the population, the size and the orbital distribution of IEOs, AsteroidFinder will contribute to our knowledge of the inner Solar System, and to the assessment of the impact hazard for the Earth. A secondary goal of the mission is to demonstrate techniques that enable the space-based detection of space debris in the cm size range

  10. Starting a Planet Protectors Club

    Science.gov (United States)

    US Environmental Protection Agency, 2007

    2007-01-01

    If your mission is to teach children how to reduce, reuse, and recycle waste and create the next generation of Planet Protectors, perhaps leading a Planet Protectors Club is part of your future challenges. You don't have to be an expert in waste reduction and recycling to lead a a Planet Protectors Club. You don't even have to be a teacher. You do…

  11. Planet map generation by tetrahedral subdivision

    DEFF Research Database (Denmark)

    Mogensen, Torben Ægidius

    2010-01-01

    We present a method for generating pseudo-random, zoomable planet maps for games and art.  The method is based on spatial subdivision using tetrahedrons.  This ensures planet maps without discontinuities caused by mapping a flat map onto a sphere. We compare the method to other map...

  12. BookFinder.com

    CERN Document Server

    BookFinder.com is produced by the bibliophiles at 13th Generation Media of Berkeley, California. Our goal is to provide fellow readers unbiased realtime information about books available online. Rather than selling books ourselves (does the world rea Amazon.com wannabe?), we've teamed up with over 15,000 of the finest booksellers online to bring you the largest book catalog available anywhere, either online or offline.

  13. Next-generation phylogenomics

    Directory of Open Access Journals (Sweden)

    Chan Cheong Xin

    2013-01-01

    Full Text Available Abstract Thanks to advances in next-generation technologies, genome sequences are now being generated at breadth (e.g. across environments and depth (thousands of closely related strains, individuals or samples unimaginable only a few years ago. Phylogenomics – the study of evolutionary relationships based on comparative analysis of genome-scale data – has so far been developed as industrial-scale molecular phylogenetics, proceeding in the two classical steps: multiple alignment of homologous sequences, followed by inference of a tree (or multiple trees. However, the algorithms typically employed for these steps scale poorly with number of sequences, such that for an increasing number of problems, high-quality phylogenomic analysis is (or soon will be computationally infeasible. Moreover, next-generation data are often incomplete and error-prone, and analysis may be further complicated by genome rearrangement, gene fusion and deletion, lateral genetic transfer, and transcript variation. Here we argue that next-generation data require next-generation phylogenomics, including so-called alignment-free approaches. Reviewers Reviewed by Mr Alexander Panchin (nominated by Dr Mikhail Gelfand, Dr Eugene Koonin and Prof Peter Gogarten. For the full reviews, please go to the Reviewers’ comments section.

  14. Skin Condition Finder

    Science.gov (United States)

    ... SKIN CONDITIONS HEALTH TOPICS FOR PROFESSIONALS Rash and Skin Condition Finder 1 Select Age Group Infant Child ... Toe Toe Webspace Toe Nail CLOSE About the Skin Condition Finder Have a health question or concern? ...

  15. Next generation initiation techniques

    Science.gov (United States)

    Warner, Tom; Derber, John; Zupanski, Milija; Cohn, Steve; Verlinde, Hans

    1993-01-01

    Four-dimensional data assimilation strategies can generally be classified as either current or next generation, depending upon whether they are used operationally or not. Current-generation data-assimilation techniques are those that are presently used routinely in operational-forecasting or research applications. They can be classified into the following categories: intermittent assimilation, Newtonian relaxation, and physical initialization. It should be noted that these techniques are the subject of continued research, and their improvement will parallel the development of next generation techniques described by the other speakers. Next generation assimilation techniques are those that are under development but are not yet used operationally. Most of these procedures are derived from control theory or variational methods and primarily represent continuous assimilation approaches, in which the data and model dynamics are 'fitted' to each other in an optimal way. Another 'next generation' category is the initialization of convective-scale models. Intermittent assimilation systems use an objective analysis to combine all observations within a time window that is centered on the analysis time. Continuous first-generation assimilation systems are usually based on the Newtonian-relaxation or 'nudging' techniques. Physical initialization procedures generally involve the use of standard or nonstandard data to force some physical process in the model during an assimilation period. Under the topic of next-generation assimilation techniques, variational approaches are currently being actively developed. Variational approaches seek to minimize a cost or penalty function which measures a model's fit to observations, background fields and other imposed constraints. Alternatively, the Kalman filter technique, which is also under investigation as a data assimilation procedure for numerical weather prediction, can yield acceptable initial conditions for mesoscale models. The

  16. A Direct Path to Finding Earth-Like Planets

    Science.gov (United States)

    Heap, Sara R.; Linder, Don J.

    2009-01-01

    As envisaged by the 2000 astrophysics decadal survey panel: The main goal of Terrestrial Planet Finder (TPF) is nothing less than to search for evidence of life on terrestrial planets around nearby stars . Here, we consider how an optical telescope paired with a free-flying occulter blocking light from the star can reach this goal directly, without knowledge of results from prior astrometric, doppler, or transit exoplanet observations. Using design reference missions and other simulations, we explore the potential of TPF-O to find planets in the habitable zone around their central stars, to spectrally characterize the atmospheres of detected planets, and to obtain rudimentary information about their orbits. We emphasize the importance of ozone absorption in the UV spectrum of a planet as a marker of photosynthesis by plants, algae, and cyanobacteria.

  17. What About the Children? The Threat of Nuclear War and Our Responsibility to Preserve this Planet for Future Generations.

    Science.gov (United States)

    Hawkes, Glenn W.

    Part of a global effort, this brochure was written to increase understanding of the threat nuclear war poses to children. Several issues are raised and briefly discussed, including (1) the present capacity for annihilating the next generation or ending human life on this planet, (2) the inadequacy of deterrence, (3) the suffering of children after…

  18. Possibilities for the detection of microbial life on extrasolar planets.

    Science.gov (United States)

    Knacke, Roger F

    2003-01-01

    We consider possibilities for the remote detection of microbial life on extrasolar planets. The Darwin/Terrestrial Planet Finder (TPF) telescope concepts for observations of terrestrial planets focus on indirect searches for life through the detection of atmospheric gases related to life processes. Direct detection of extraterrestrial life may also be possible through well-designed searches for microbial life forms. Satellites in Earth orbit routinely monitor colonies of terrestrial algae in oceans and lakes by analysis of reflected ocean light in the visible region of the spectrum. These remote sensing techniques suggest strategies for extrasolar searches for signatures of chlorophylls and related photosynthetic compounds associated with life. However, identification of such life-related compounds on extrasolar planets would require observations through strong, interfering absorptions and scattering radiances from the remote atmospheres and landmasses. Techniques for removal of interfering radiances have been extensively developed for remote sensing from Earth orbit. Comparable techniques would have to be developed for extrasolar planet observations also, but doing so would be challenging for a remote planet. Darwin/TPF coronagraph concepts operating in the visible seem to be best suited for searches for extrasolar microbial life forms with instruments that can be projected for the 2010-2020 decades, although resolution and signal-to-noise ratio constraints severely limit detection possibilities on terrestrial-type planets. The generation of telescopes with large apertures and extremely high spatial resolutions that will follow Darwin/TPF could offer striking possibilities for the direct detection of extrasolar microbial life.

  19. IdentiFINDER Laboratory Exercise

    Energy Technology Data Exchange (ETDEWEB)

    Weinmann-Smith, Robert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-09-21

    The identiFINDER2 is an easily portable handheld NaI gamma detector. The IAEA uses the safeguards version of the identiFINDER2 and calls it the HM-5. The HM-5 has built in software to analyze the detection signal specifically for IAEA verification applications.

  20. A next generation field-portable goniometer system

    Science.gov (United States)

    Harms, Justin D.; Bachmann, Charles M.; Faulring, Jason W.; Ruiz Torres, Andres J.

    2016-05-01

    Various field portable goniometers have been designed to capture in-situ measurements of a materials bi-directional reflectance distribution function (BRDF), each with a specific scientific purpose in mind.1-4 The Rochester Institute of Technology's (RIT) Chester F. Carlson Center for Imaging Science recently created a novel instrument incorporating a wide variety of features into one compact apparatus in order to obtain very high accuracy BRDFs of short vegetation and sediments, even in undesirable conditions and austere environments. This next generation system integrates a dual-view design using two VNIR/SWIR pectroradiometers to capture target reflected radiance, as well as incoming radiance, to provide for better optical accuracy when measuring in non-ideal atmospheric conditions or when background illumination effects are non-negligible. The new, fully automated device also features a laser range finder to construct a surface roughness model of the target being measured, which enables the user to include inclination information into BRDF post-processing and further allows for roughness effects to be better studied for radiative transfer modeling. The highly portable design features automatic leveling, a precision engineered frame, and a variable measurement plane that allow for BRDF measurements on rugged, un-even terrain while still maintaining true angular measurements with respect to the target, all without sacrificing measurement speed. Despite the expanded capabilities and dual sensor suite, the system weighs less than 75 kg, which allows for excellent mobility and data collection on soft, silty clay or fine sand.

  1. Next generation light water reactors

    International Nuclear Information System (INIS)

    Omoto, Akira

    1992-01-01

    In the countries where the new order of nuclear reactors has ceased, the development of the light water reactors of new type has been discussed, aiming at the revival of nuclear power. Also in Japan, since it is expected that light water reactors continue to be the main power reactor for long period, the technology of light water reactors of next generation has been discussed. For the development of nuclear power, extremely long lead time is required. The light water reactors of next generation now in consideration will continue to be operated till the middle of the next century, therefore, they must take in advance sufficiently the needs of the age. The improvement of the way men and the facilities should be, the simple design, the flexibility to the trend of fuel cycle and so on are required for the light water reactors of next generation. The trend of the development of next generation light water reactors is discussed. The construction of an ABWR was started in September, 1991, as No. 6 plant in Kashiwazaki Kariwa Power Station. (K.I.)

  2. Digital Earth reloaded - Beyond the next generation

    Science.gov (United States)

    Ehlers, M.; Woodgate, P.; Annoni, A.; Schade, S.

    2014-02-01

    Digital replicas (or 'mirror worlds') of complex entities and systems are now routine in many fields such as aerospace engineering; archaeology; medicine; or even fashion design. The Digital Earth (DE) concept as a digital replica of the entire planet occurs in Al Gore's 1992 book Earth in the Balance and was popularized in his speech at the California Science Center in January 1998. It played a pivotal role in stimulating the development of a first generation of virtual globes, typified by Google Earth that achieved many elements of this vision. Almost 15 years after Al Gore's speech, the concept of DE needs to be re-evaluated in the light of the many scientific and technical developments in the fields of information technology, data infrastructures, citizen?s participation, and earth observation that have taken place since. This paper intends to look beyond the next generation predominantly based on the developments of fields outside the spatial sciences, where concepts, software, and hardware with strong relationships to DE are being developed without referring to this term. It also presents a number of guiding criteria for future DE developments.

  3. trieFinder: an efficient program for annotating Digital Gene Expression (DGE) tags.

    Science.gov (United States)

    Renaud, Gabriel; LaFave, Matthew C; Liang, Jin; Wolfsberg, Tyra G; Burgess, Shawn M

    2014-10-13

    Quantification of a transcriptional profile is a useful way to evaluate the activity of a cell at a given point in time. Although RNA-Seq has revolutionized transcriptional profiling, the costs of RNA-Seq are still significantly higher than microarrays, and often the depth of data delivered from RNA-Seq is in excess of what is needed for simple transcript quantification. Digital Gene Expression (DGE) is a cost-effective, sequence-based approach for simple transcript quantification: by sequencing one read per molecule of RNA, this technique can be used to efficiently count transcripts while obviating the need for transcript-length normalization and reducing the total numbers of reads necessary for accurate quantification. Here, we present trieFinder, a program specifically designed to rapidly map, parse, and annotate DGE tags of various lengths against cDNA and/or genomic sequence databases. The trieFinder algorithm maps DGE tags in a two-step process. First, it scans FASTA files of RefSeq, UniGene, and genomic DNA sequences to create a database of all tags that can be derived from a predefined restriction site. Next, it compares the experimental DGE tags to this tag database, taking advantage of the fact that the tags are stored as a prefix tree, or "trie", which allows for linear-time searches for exact matches. DGE tags with mismatches are analyzed by recursive calls in the data structure. We find that, in terms of alignment speed, the mapping functionality of trieFinder compares favorably with Bowtie. trieFinder can quickly provide the user an annotation of the DGE tags from three sources simultaneously, simplifying transcript quantification and novel transcript detection, delivering the data in a simple parsed format, obviating the need to post-process the alignment results. trieFinder is available at http://research.nhgri.nih.gov/software/trieFinder/.

  4. Introduction to IdentiFINDERs

    Energy Technology Data Exchange (ETDEWEB)

    Rees, Brian G. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2018-02-05

    These are slides from a presentation. The identiFINDER provides information on radiation levels. It can automatically identify isotopes in its library. It can save spectra for transfer to a computer, and has a 4-8 hour battery life. The following is covered: an overview, operating modes, getting started, finder mode, search, identification mode, dose & rate, warning & alarm, options (ultra LGH), options (identifinder2), and general procedure.

  5. BS-virus-finder

    DEFF Research Database (Denmark)

    Gao, Shengjie; Hu, Xuesong; Xu, Fengping

    2018-01-01

    Background: DNA methylation plays a key role in the regulation of gene expression and carcinogenesis. Bisulfite sequencing studies mainly focus on calling SNP, DMR, and ASM. Until now, only a few software tools focus on virus integration using bisulfite sequencing data. Findings: We have developed...... a new and easy-to-use software tool, named BS-virus-finder (BSVF, RRID:SCR_015727), to detect viral integration breakpoints in whole human genomes. The tool is hosted at https://github.com/BGI-SZ/BSVF. Conclusions: BS-virus-finder demonstrates high sensitivity and specificity. It is useful in epigenetic...

  6. Generation Next

    Science.gov (United States)

    Hawkins, B. Denise

    2010-01-01

    There is a shortage of accounting professors with Ph.D.s who can prepare the next generation. To help reverse the faculty deficit, the American Institute of Certified Public Accountants (CPAs) has created the new Accounting Doctoral Scholars program by pooling more than $17 million and soliciting commitments from more than 70 of the nation's…

  7. Digital Earth reloaded – Beyond the next generation

    International Nuclear Information System (INIS)

    Ehlers, M; Woodgate, P; Annoni, A; Schade, S

    2014-01-01

    Digital replicas (or 'mirror worlds') of complex entities and systems are now routine in many fields such as aerospace engineering; archaeology; medicine; or even fashion design. The Digital Earth (DE) concept as a digital replica of the entire planet occurs in Al Gore's 1992 book Earth in the Balance and was popularized in his speech at the California Science Center in January 1998. It played a pivotal role in stimulating the development of a first generation of virtual globes, typified by Google Earth that achieved many elements of this vision. Almost 15 years after Al Gore's speech, the concept of DE needs to be re-evaluated in the light of the many scientific and technical developments in the fields of information technology, data infrastructures, citizen?s participation, and earth observation that have taken place since. This paper intends to look beyond the next generation predominantly based on the developments of fields outside the spatial sciences, where concepts, software, and hardware with strong relationships to DE are being developed without referring to this term. It also presents a number of guiding criteria for future DE developments

  8. Next Generation Microshutter Arrays Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to develop the next generation MicroShutter Array (MSA) as a multi-object field selector for missions anticipated in the next two decades. For many...

  9. Project control - the next generation

    International Nuclear Information System (INIS)

    Iorii, V.F.; McKinnon, B.L.

    1993-01-01

    The Yucca Mountain Site Characterization Project (YMP) is the U.S. Department of Energy's (DOE) second largest Major System Acquisition Project. We have developed an integrated planning and control system (called PACS) that we believe represents the 'Next Generation' in project control. PACS integrates technical scope, cost, and schedule information for over 50 participating organizations and produces performances measurement reports for science and engineering managers at all levels. Our 'Next Generation' project control too, PACS, has been found to be in compliance with the new DOE Project Control System Guidelines. Additionally, the nuclear utility oversight group of the Edison Electric Institute has suggested PACS be used as a model for other civilian radioactive waste management projects. A 'Next Generation' project control tool will be necessary to do science in the 21st century

  10. Directional Wide-Angle Range Finder (DWARF)

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed innovation, the Directional Wide-Angle Range Finder (DWARF) is the creation of a laser range-finder with a wide field-of-view (FOV) and a directional...

  11. The hardware track finder processor in CMS at CERN

    CERN Document Server

    Kluge, A

    1997-01-01

    The work covers the design of the Track Finder Processor in the high energy experiment CMS (Compact Muon Solenoid, planned for 2005) at CERN/Geneva. The task of this processor is to identify muons and measure their transverse momentum. The track finder processor makes it possible to determine the physical relevance of each high energetic collision and to forward only interesting data to the data an alysis units. Data of more than two hundred thousand detector cells are used to determine the location of muons and measure their transverse momentum. Each 25 ns a new data set is generated. Measurem ent of location and transverse momentum of the muons can be terminated within 350 ns by using an ASIC (Application Specific Integrated Circuit). A pipeline architecture processes new data sets with th e required data rate of 40 MHz to ensure dead time free operation. In the framework of this study specifications and the overall concept of the track finder processor were worked out in detail. Simul ations were performed...

  12. Infrared radiation scene generation of stars and planets in celestial background

    Science.gov (United States)

    Guo, Feng; Hong, Yaohui; Xu, Xiaojian

    2014-10-01

    An infrared (IR) radiation generation model of stars and planets in celestial background is proposed in this paper. Cohen's spectral template1 is modified for high spectral resolution and accuracy. Based on the improved spectral template for stars and the blackbody assumption for planets, an IR radiation model is developed which is able to generate the celestial IR background for stars and planets appearing in sensor's field of view (FOV) for specified observing date and time, location, viewpoint and spectral band over 1.2μm ~ 35μm. In the current model, the initial locations of stars are calculated based on midcourse space experiment (MSX) IR astronomical catalogue (MSX-IRAC) 2 , while the initial locations of planets are calculated using secular variations of the planetary orbits (VSOP) theory. Simulation results show that the new IR radiation model has higher resolution and accuracy than common model.

  13. SNAP: Small Next-generation Atmospheric Probe Concept

    Science.gov (United States)

    Sayanagi, K. M.; Dillman, R. A.; Atkinson, D. H.; Li, J.; Saikia, S.; Simon, A. A.; Spilker, T. R.; Wong, M. H.; Hope, D.

    2017-12-01

    We present a concept for a small, atmospheric probe that could be flexibly added to future missions that orbit or fly-by a giant planet as a secondary payload, which we call the Small Next-generation Atmospheric Probe (SNAP). SNAP's main scientific objectives are to determine the vertical distribution of clouds and cloud-forming chemical species, thermal stratification, and wind speed as a function of depth. As a case study, we present the advantages, cost and risk of adding SNAP to the future Uranus Orbiter and Probe flagship mission; in combination with the mission's main probe, SNAP would perform atmospheric in-situ measurements at a second location, and thus enable and enhance the scientific objectives recommended by the 2013 Planetary Science Decadal Survey and the 2014 NASA Science Plan to determine atmospheric spatial variabilities. We envision that the science objectives can be achieved with a 30-kg entry probe 0.5m in diameter (less than half the size of the Galileo probe) that reaches 5-bar pressure-altitude and returns data to Earth via the carrier spacecraft. As the baseline instruments, the probe will carry an Atmospheric Structure Instrument (ASI) that measures the temperature, pressure and acceleration, a carbon nanotube-based NanoChem atmospheric composition sensor, and an Ultra-Stable Oscillator (USO) to conduct a Doppler Wind Experiment (DWE). We also catalog promising technologies currently under development that will strengthen small atmospheric entry probe missions in the future. While SNAP is applicable to multiple planets, we examine the feasibility, benefits and impacts of adding SNAP to the Uranus Orbiter and Probe flagship mission. Our project is supported by NASA PSDS3 grant NNX17AK31G.

  14. Next-Generation Tools For Next-Generation Surveys

    Science.gov (United States)

    Murray, S. G.

    2017-04-01

    The next generation of large-scale galaxy surveys, across the electromagnetic spectrum, loom on the horizon as explosively game-changing datasets, in terms of our understanding of cosmology and structure formation. We are on the brink of a torrent of data that is set to both confirm and constrain current theories to an unprecedented level, and potentially overturn many of our conceptions. One of the great challenges of this forthcoming deluge is to extract maximal scientific content from the vast array of raw data. This challenge requires not only well-understood and robust physical models, but a commensurate network of software implementations with which to efficiently apply them. The halo model, a semi-analytic treatment of cosmological spatial statistics down to nonlinear scales, provides an excellent mathematical framework for exploring the nature of dark matter. This thesis presents a next-generation toolkit based on the halo model formalism, intended to fulfil the requirements of next-generation surveys. Our toolkit comprises three tools: (i) hmf, a comprehensive and flexible calculator for halo mass functions (HMFs) within extended Press-Schechter theory, (ii) the MRP distribution for extremely efficient analytic characterisation of HMFs, and (iii) halomod, an extension of hmf which provides support for the full range of halo model components. In addition to the development and technical presentation of these tools, we apply each to the task of physical modelling. With hmf, we determine the precision of our knowledge of the HMF, due to uncertainty in our knowledge of the cosmological parameters, over the past decade of cosmic microwave background (CMB) experiments. We place rule-of-thumb uncertainties on the predicted HMF for the Planck cosmology, and find that current limits on the precision are driven by modeling uncertainties rather than those from cosmological parameters. With the MRP, we create and test a method for robustly fitting the HMF to observed

  15. Dynalight Next Generation

    DEFF Research Database (Denmark)

    Jørgensen, Bo Nørregaard; Ottosen, Carl-Otto; Dam-Hansen, Carsten

    2016-01-01

    The project aims to develop the next generation of energy cost-efficient artificial lighting control that enables greenhouse growers to adapt their use of artificial lighting dynamically to fluctuations in the price of electricity. This is a necessity as fluctuations in the price of electricity c...

  16. NASA's Next Generation Space Geodesy Program

    Science.gov (United States)

    Merkowitz, S. M.; Desai, S. D.; Gross, R. S.; Hillard, L. M.; Lemoine, F. G.; Long, J. L.; Ma, C.; McGarry, J. F.; Murphy, D.; Noll, C. E.; hide

    2012-01-01

    Requirements for the ITRF have increased dramatically since the 1980s. The most stringent requirement comes from critical sea level monitoring programs: a global accuracy of 1.0 mm, and 0.1mm/yr stability, a factor of 10 to 20 beyond current capability. Other requirements for the ITRF coming from ice mass change, ground motion, and mass transport studies are similar. Current and future satellite missions will have ever-increasing measurement capability and will lead to increasingly sophisticated models of these and other changes in the Earth system. Ground space geodesy networks with enhanced measurement capability will be essential to meeting the ITRF requirements and properly interpreting the satellite data. These networks must be globally distributed and built for longevity, to provide the robust data necessary to generate improved models for proper interpretation of the observed geophysical signals. NASA has embarked on a Space Geodesy Program with a long-range goal to build, deploy and operate a next generation NASA Space Geodetic Network (SGN). The plan is to build integrated, multi-technique next-generation space geodetic observing systems as the core contribution to a global network designed to produce the higher quality data required to maintain the Terrestrial Reference Frame and provide information essential for fully realizing the measurement potential of the current and coming generation of Earth Observing spacecraft. Phase 1 of this project has been funded to (1) Establish and demonstrate a next-generation prototype integrated Space Geodetic Station at Goddard's Geophysical and Astronomical Observatory (GGAO), including next-generation SLR and VLBI systems along with modern GNSS and DORIS; (2) Complete ongoing Network Design Studies that describe the appropriate number and distribution of next-generation Space Geodetic Stations for an improved global network; (3) Upgrade analysis capability to handle the next-generation data; (4) Implement a modern

  17. Generation 'Next' and nuclear power

    International Nuclear Information System (INIS)

    Sergeev, A.A.

    2001-01-01

    My generation was labeled by Russian mass media as generation 'Next.' My technical education is above average. My current position is as a mechanical engineer in the leading research and development institute for Russian nuclear engineering for peaceful applications. It is noteworthy to point out that many of our developments were really first-of-a-kind in the history of engineering. However, it is difficult to grasp the importance of these accomplishments, especially since the progress of nuclear technologies is at a standstill. Can generation 'Next' be independent in their attitude towards nuclear power or shall we rely on the opinions of elder colleagues in our industry? (authors)

  18. The Next Great Generation?

    Science.gov (United States)

    Brownstein, Andrew

    2000-01-01

    Discusses ideas from a new book, "Millennials Rising: The Next Great Generation," (by Neil Howe and William Strauss) suggesting that youth culture is on the cusp of a radical shift with the generation beginning with this year's college freshmen who are typically team oriented, optimistic, and poised for greatness on a global scale. Includes a…

  19. Development of technology for next generation reactor - Development of next generation reactor in Korea -

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jong Kyun; Chang, Moon Heuy; Hwang, Yung Dong [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of); and others

    1993-09-01

    The project, development of next generation reactor, aims overall related technology development and obtainment of related license in 2001. The development direction is to determine the reactor type and to build up the design concept in 1994. For development trend analysis of foreign next generation reactor, level-1 PSA, fuel cycle analysis and computer code development are performed on System 80+ and AP 600. Especially for design characteristics analysis and volume upgrade of AP 600, nuclear fuel and reactor core design analysis, coolant circuit design analysis, mechanical structure design analysis and safety analysis etc. are performed. (Author).

  20. Tailoring next-generation biofuels and their combustion in next-generation engines

    Energy Technology Data Exchange (ETDEWEB)

    Gladden, John Michael [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Wu, Weihua [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Taatjes, Craig A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Scheer, Adam Michael [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Turner, Kevin M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Yu, Eizadora T. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); O' Bryan, Greg [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Powell, Amy Jo [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gao, Connie W. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

    2013-11-01

    Increasing energy costs, the dependence on foreign oil supplies, and environmental concerns have emphasized the need to produce sustainable renewable fuels and chemicals. The strategy for producing next-generation biofuels must include efficient processes for biomass conversion to liquid fuels and the fuels must be compatible with current and future engines. Unfortunately, biofuel development generally takes place without any consideration of combustion characteristics, and combustion scientists typically measure biofuels properties without any feedback to the production design. We seek to optimize the fuel/engine system by bringing combustion performance, specifically for advanced next-generation engines, into the development of novel biosynthetic fuel pathways. Here we report an innovative coupling of combustion chemistry, from fundamentals to engine measurements, to the optimization of fuel production using metabolic engineering. We have established the necessary connections among the fundamental chemistry, engine science, and synthetic biology for fuel production, building a powerful framework for co-development of engines and biofuels.

  1. Cluster cosmology with next-generation surveys.

    Science.gov (United States)

    Ascaso, B.

    2017-03-01

    The advent of next-generation surveys will provide a large number of cluster detections that will serve the basis for constraining cos mological parameters using cluster counts. The main two observational ingredients needed are the cluster selection function and the calibration of the mass-observable relation. In this talk, we present the methodology designed to obtain robust predictions of both ingredients based on realistic cosmological simulations mimicking the following next-generation surveys: J-PAS, LSST and Euclid. We display recent results on the selection functions for these mentioned surveys together with others coming from other next-generation surveys such as eROSITA, ACTpol and SPTpol. We notice that the optical and IR surveys will reach the lowest masses between 0.3next-generation surveys and introduce very preliminary results.

  2. Basic Testing of the DUCHAMP Source Finder

    Science.gov (United States)

    Westmeier, T.; Popping, A.; Serra, P.

    2012-01-01

    This paper presents and discusses the results of basic source finding tests in three dimensions (using spectroscopic data cubes) with DUCHAMP, the standard source finder for the Australian Square Kilometre Array Pathfinder. For this purpose, we generated different sets of unresolved and extended Hi model sources. These models were then fed into DUCHAMP, using a range of different parameters and methods provided by the software. The main aim of the tests was to study the performance of DUCHAMP on sources with different parameters and morphologies and assess the accuracy of DUCHAMP's source parametrisation. Overall, we find DUCHAMP to be a powerful source finder capable of reliably detecting sources down to low signal-to-noise ratios and accurately measuring their position and velocity. In the presence of noise in the data, DUCHAMP's measurements of basic source parameters, such as spectral line width and integrated flux, are affected by systematic errors. These errors are a consequence of the effect of noise on the specific algorithms used by DUCHAMP for measuring source parameters in combination with the fact that the software only takes into account pixels above a given flux threshold and hence misses part of the flux. In scientific applications of DUCHAMP these systematic errors would have to be corrected for. Alternatively, DUCHAMP could be used as a source finder only, and source parametrisation could be done in a second step using more sophisticated parametrisation algorithms.

  3. A neural network gravitational arc finder based on the Mediatrix filamentation method

    Science.gov (United States)

    Bom, C. R.; Makler, M.; Albuquerque, M. P.; Brandt, C. H.

    2017-01-01

    Context. Automated arc detection methods are needed to scan the ongoing and next-generation wide-field imaging surveys, which are expected to contain thousands of strong lensing systems. Arc finders are also required for a quantitative comparison between predictions and observations of arc abundance. Several algorithms have been proposed to this end, but machine learning methods have remained as a relatively unexplored step in the arc finding process. Aims: In this work we introduce a new arc finder based on pattern recognition, which uses a set of morphological measurements that are derived from the Mediatrix filamentation method as entries to an artificial neural network (ANN). We show a full example of the application of the arc finder, first training and validating the ANN on simulated arcs and then applying the code on four Hubble Space Telescope (HST) images of strong lensing systems. Methods: The simulated arcs use simple prescriptions for the lens and the source, while mimicking HST observational conditions. We also consider a sample of objects from HST images with no arcs in the training of the ANN classification. We use the training and validation process to determine a suitable set of ANN configurations, including the combination of inputs from the Mediatrix method, so as to maximize the completeness while keeping the false positives low. Results: In the simulations the method was able to achieve a completeness of about 90% with respect to the arcs that are input into the ANN after a preselection. However, this completeness drops to 70% on the HST images. The false detections are on the order of 3% of the objects detected in these images. Conclusions: The combination of Mediatrix measurements with an ANN is a promising tool for the pattern-recognition phase of arc finding. More realistic simulations and a larger set of real systems are needed for a better training and assessment of the efficiency of the method.

  4. Next Generation Inverter

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Zilai [General Motors LLC, Detroit, MI (United States); Gough, Charles [General Motors LLC, Detroit, MI (United States)

    2016-04-22

    The goal of this Cooperative Agreement was the development of a Next Generation Inverter for General Motors’ electrified vehicles, including battery electric vehicles, range extended electric vehicles, plug-in hybrid electric vehicles and hybrid electric vehicles. The inverter is a critical electronics component that converts battery power (DC) to and from the electric power for the motor (AC).

  5. Technical presentation: Next Generation Oscilloscopes

    CERN Multimedia

    PH Department

    2011-01-01

      Rohde & Schwarz "Next Generation Oscilloscopes" - Introduction and Presentation Agenda: Wednesday 23 March  -  09:30 to 11:30 (open end) Bldg. 13-2-005 Language: English 09.30 Presentation "Next Generation Oscilloscopes" from Rohde & Schwarz RTO / RTM in theory and practice Gerard Walker 10.15 Technical design details from R&D Dr. Markus Freidhof 10.45 Scope and Probe Roadmap (confidential) Guido Schulze 11.00 Open Discussion Feedback, first impression, wishes, needs and requirements from CERN All 11.30 Expert Talks, Hands on All Mr. Dr. Markus Freidhof, Head of R&D Oscilloscopes, Rohde & Schwarz, Germany; Mr. Guido Schulze, ...

  6. Next generation toroidal devices

    International Nuclear Information System (INIS)

    Yoshikawa, Shoichi

    1998-10-01

    A general survey of the possible approach for the next generation toroidal devices was made. Either surprisingly or obviously (depending on one's view), the technical constraints along with the scientific considerations lead to a fairly limited set of systems for the most favorable approach for the next generation devices. Specifically if the magnetic field strength of 5 T or above is to be created by superconducting coils, it imposes minimum in the aspect ratio for the tokamak which is slightly higher than contemplated now for ITER design. The similar technical constraints make the minimum linear size of a stellarator large. Scientifically, it is indicated that a tokamak of 1.5 times in the linear dimension should be able to produce economically, especially if a hybrid reactor is allowed. For the next stellarator, it is strongly suggested that some kind of helical axis is necessary both for the (almost) absolute confinement of high energy particles and high stability and equilibrium beta limits. The author still favors a heliac most. Although it may not have been clearly stated in the main text, the stability afforded by the shearless layer may be exploited fully in a stellarator. (author)

  7. Next generation toroidal devices

    Energy Technology Data Exchange (ETDEWEB)

    Yoshikawa, Shoichi [Princeton Plasma Physics Lab., Princeton Univ., NJ (United States)

    1998-10-01

    A general survey of the possible approach for the next generation toroidal devices was made. Either surprisingly or obviously (depending on one`s view), the technical constraints along with the scientific considerations lead to a fairly limited set of systems for the most favorable approach for the next generation devices. Specifically if the magnetic field strength of 5 T or above is to be created by superconducting coils, it imposes minimum in the aspect ratio for the tokamak which is slightly higher than contemplated now for ITER design. The similar technical constraints make the minimum linear size of a stellarator large. Scientifically, it is indicated that a tokamak of 1.5 times in the linear dimension should be able to produce economically, especially if a hybrid reactor is allowed. For the next stellarator, it is strongly suggested that some kind of helical axis is necessary both for the (almost) absolute confinement of high energy particles and high stability and equilibrium beta limits. The author still favors a heliac most. Although it may not have been clearly stated in the main text, the stability afforded by the shearless layer may be exploited fully in a stellarator. (author)

  8. A Next Generation BioPhotonics Workstation

    DEFF Research Database (Denmark)

    Glückstad, Jesper; Palima, Darwin; Tauro, Sandeep

    2011-01-01

    We are developing a Next Generation BioPhotonics Workstation to be applied in research on regulated microbial cell growth including their underlying physiological mechanisms, in vivo characterization of cell constituents and manufacturing of nanostructures and meta-materials.......We are developing a Next Generation BioPhotonics Workstation to be applied in research on regulated microbial cell growth including their underlying physiological mechanisms, in vivo characterization of cell constituents and manufacturing of nanostructures and meta-materials....

  9. MobilomeFINDER: web-based tools for in silico and experimental discovery of bacterial genomic islands

    OpenAIRE

    Ou, Hong-Yu; He, Xinyi; Harrison, Ewan M.; Kulasekara, Bridget R.; Thani, Ali Bin; Kadioglu, Aras; Lory, Stephen; Hinton, Jay C. D.; Barer, Michael R.; Deng, Zixin; Rajakumar, Kumar

    2007-01-01

    MobilomeFINDER (http://mml.sjtu.edu.cn/MobilomeFINDER) is an interactive online tool that facilitates bacterial genomic island or ‘mobile genome’ (mobilome) discovery; it integrates the ArrayOme and tRNAcc software packages. ArrayOme utilizes a microarray-derived comparative genomic hybridization input data set to generate ‘inferred contigs’ produced by merging adjacent genes classified as ‘present’. Collectively these ‘fragments’ represent a hypothetical ‘microarray-visualized genome (MVG)’....

  10. Next Generation Microchannel Heat Exchangers

    CERN Document Server

    Ohadi, Michael; Dessiatoun, Serguei; Cetegen, Edvin

    2013-01-01

    In Next Generation Microchannel Heat Exchangers, the authors’ focus on the new generation highly efficient heat exchangers and presentation of novel data and technical expertise not available in the open literature.  Next generation micro channels offer record high heat transfer coefficients with pressure drops much less than conventional micro channel heat exchangers. These inherent features promise fast penetration into many mew markets, including high heat flux cooling of electronics, waste heat recovery and energy efficiency enhancement applications, alternative energy systems, as well as applications in mass exchangers and chemical reactor systems. The combination of up to the minute research findings and technical know-how make this book very timely as the search for high performance heat and mass exchangers that can cut costs in materials consumption intensifies.

  11. RES-E-NEXT: Next Generation of RES-E Policy Instruments

    Energy Technology Data Exchange (ETDEWEB)

    Miller, M.; Bird, L.; Cochran, J.; Milligan, M.; Bazilian, M. [National Renewable Energy Laboratory, Golden, CO (United States); Denny, E.; Dillon, J.; Bialek, J.; O’Malley, M. [Ecar Limited (Ireland); Neuhoff, K. [DIW Berlin (Germany)

    2013-07-04

    The RES-E-NEXT study identifies policies that are required for the next phase of renewable energy support. The study analyses policy options that secure high shares of renewable electricity generation and adequate grid infrastructure, enhance flexibility and ensure an appropriate market design. Measures have limited costs or even save money, and policies can be gradually implemented.

  12. Progress on next generation linear colliders

    International Nuclear Information System (INIS)

    Ruth, R.D.

    1989-01-01

    In this paper, I focus on reviewing the issues and progress on a next generation linear collider with the general parameters of energy, luminosity, length, power, technology. The energy range is dictated by physics with a mass reach well beyond LEP, although somewhat short of SSC. The luminosity is that required to obtain 10 3 /minus/ 10 4 units of R 0 per year. The length is consistent with a site on Stanford land with collisions occurring on the SLAC site. The power was determined by economic considerations. Finally, the technology was limited by the desire to have a next generation linear collider before the next century. 25 refs., 3 figs., 6 tabs

  13. Healthcare Finder API

    Data.gov (United States)

    U.S. Department of Health & Human Services — All of the data used on the Finder.HealthCare.gov web application is available through this API. There are multiple collections of data available through the API. 1....

  14. Next generation of accelerators

    International Nuclear Information System (INIS)

    Richter, B.

    1979-01-01

    Existing high-energy accelerators are reviewed, along with those under construction or being designed. Finally, some of the physics issues which go into setting machine parameters, and some of the features of the design of next generation electron and proton machines are discussed

  15. Prospects for next-generation e+e- linear colliders

    International Nuclear Information System (INIS)

    Ruth, R.D.

    1990-02-01

    The purpose of this paper is to review progress in the US towards a next generation linear collider. During 1988, there were three workshops held on linear colliders: ''Physics of Linear Colliders,'' in Capri, Italy, June 14--18, 1988; Snowmass 88 (Linear Collider subsection) June 27--July 15, 1988; and SLAC International Workshop on Next Generation Linear Colliders, November 28--December 9, 1988. In this paper, I focus on reviewing the issues and progress on a next generation linear collider. The energy range is dictated by physics with a mass reach well beyond LEP, although somewhat short of SSC. The luminosity is that required to obtain 10 3 --10 4 units of R 0 per year. The length is consistent with a site on Stanford land with collision occurring on the SLAC site; the power was determined by economic considerations. Finally, the technology as limited by the desire to have a next generation linear collider by the next century. 37 refs., 3 figs., 6 tabs

  16. Overview of NASA's Next Generation Air Transportation System (NextGen) Research

    Science.gov (United States)

    Swenson, Harry N.

    2009-01-01

    This slide presentation is an overview of the research for the Next Generation Air Transportation System (NextGen). Included is a review of the current air transportation system and the challenges of air transportation research. Also included is a review of the current research highlights and significant accomplishments.

  17. Symbolic PathFinder v7

    DEFF Research Database (Denmark)

    Luckow, Kasper Søe; Păsăreanu, Corina

    2014-01-01

    We describe Symbolic PathFinder v7 in terms of its updated design addressing the changes of Java PathFinder v7 and of its new optimization when computing path conditions. Furthermore, we describe the Symbolic Execution Tree Extension; a newly added feature that allows for outputting the symbolic...... execution tree that characterizes the execution paths covered during symbolic execution. The new extension can be tailored to the needs of subsequent analyses/processing facilities, and we demonstrate this by presenting SPF-Visualizer, which is a tool for customizable visualization of the symbolic execution...

  18. Next Generation Social Networks

    DEFF Research Database (Denmark)

    Sørensen, Lene Tolstrup; Skouby, Knud Erik

    2008-01-01

    different online networks for communities of people who share interests or individuals who presents themselves through user produced content is what makes up the social networking of today. The purpose of this paper is to discuss perceived user requirements to the next generation social networks. The paper...

  19. Next generation CANDU plants

    International Nuclear Information System (INIS)

    Hedges, K.R.; Yu, S.K.W.

    1998-01-01

    Future CANDU designs will continue to meet the emerging design and performance requirements expected by the operating utilities. The next generation CANDU products will integrate new technologies into both the product features as well as into the engineering and construction work processes associated with delivering the products. The timely incorporation of advanced design features is the approach adopted for the development of the next generation of CANDU. AECL's current products consist of 700MW Class CANDU 6 and 900 MW Class CANDU 9. Evolutionary improvements are continuing with our CANDU products to enhance their adaptability to meet customers ever increasing need for higher output. Our key product drivers are for improved safety, environmental protection and improved cost effectiveness. Towards these goals we have made excellent progress in Research and Development and our investments are continuing in areas such as fuel channels and passive safety. Our long term focus is utilizing the fuel cycle flexibility of CANDU reactors as part of the long term energy mix

  20. Optical Subsystems for Next Generation Access Networks

    DEFF Research Database (Denmark)

    Lazaro, J.A; Polo, V.; Schrenk, B.

    2011-01-01

    Recent optical technologies are providing higher flexibility to next generation access networks: on the one hand, providing progressive FTTx and specifically FTTH deployment, progressively shortening the copper access network; on the other hand, also opening fixed-mobile convergence solutions...... in next generation PON architectures. It is provided an overview of the optical subsystems developed for the implementation of the proposed NG-Access Networks....

  1. Building next-generation converged networks theory and practice

    CERN Document Server

    Pathan, Al-Sakib Khan

    2013-01-01

    Supplying a comprehensive introduction to next-generation networks, Building Next-Generation Converged Networks: Theory and Practice strikes a balance between how and why things work and how to make them work. It compiles recent advancements along with basic issues from the wide range of fields related to next generation networks. Containing the contributions of 56 industry experts and researchers from 16 different countries, the book presents relevant theoretical frameworks and the latest research. It investigates new technologies such as IPv6 over Low Power Wireless Personal Area Network (6L

  2. Key thrusts in next generation CANDU. Annex 10

    International Nuclear Information System (INIS)

    Shalaby, B.A.; Torgerson, D.F.; Duffey, R.B.

    2002-01-01

    Current electricity markets and the competitiveness of other generation options such as CCGT have influenced the directions of future nuclear generation. The next generation CANDU has used its key characteristics as the basis to leap frog into a new design featuring improved economics, enhanced passive safety, enhanced operability and demonstrated fuel cycle flexibility. Many enabling technologies spinning of current CANDU design features are used in the next generation design. Some of these technologies have been developed in support of existing plants and near term designs while others will need to be developed and tested. This paper will discuss the key principles driving the next generation CANDU design and the fuel cycle flexibility of the CANDU system which provide synergism with the PWR fuel cycle. (author)

  3. GLS-Finder: A Platform for Fast Profiling of Glucosinolates in Brassica Vegetables.

    Science.gov (United States)

    Sun, Jianghao; Zhang, Mengliang; Chen, Pei

    2016-06-01

    Mass spectrometry combined with related tandem techniques has become the most popular method for plant secondary metabolite characterization. We introduce a new strategy based on in-database searching, mass fragmentation behavior study, formula predicting for fast profiling of glucosinolates, a class of important compounds in brassica vegetables. A MATLAB script-based expert system computer program, "GLS-Finder", was developed. It is capable of qualitative and semi-quantitative analyses of glucosinolates in samples using data generated by ultrahigh-performance liquid chromatography-high-resolution accurate mass with multi-stage mass fragmentation (UHPLC-HRAM/MS(n)). A suite of bioinformatic tools was integrated into the "GLS-Finder" to perform raw data deconvolution, peak alignment, glucosinolate putative assignments, semi-quantitation, and unsupervised principal component analysis (PCA). GLS-Finder was successfully applied to identify intact glucosinolates in 49 commonly consumed Brassica vegetable samples in the United States. It is believed that this work introduces a new way of fast data processing and interpretation for qualitative and quantitative analyses of glucosinolates, where great efficacy was improved in comparison to identification manually.

  4. Next Generation Biopharmaceuticals: Product Development.

    Science.gov (United States)

    Mathaes, Roman; Mahler, Hanns-Christian

    2018-04-11

    Therapeutic proteins show a rapid market growth. The relatively young biotech industry already represents 20 % of the total global pharma market. The biotech industry environment has traditionally been fast-pasted and intellectually stimulated. Nowadays the top ten best selling drugs are dominated by monoclonal antibodies (mABs).Despite mABs being the biggest medical breakthrough in the last 25 years, technical innovation does not stand still.The goal remains to preserve the benefits of a conventional mAB (serum half-life and specificity) whilst further improving efficacy and safety and to open new and better avenues for treating patients, e.g., improving the potency of molecules, target binding, tissue penetration, tailored pharmacokinetics, and reduced adverse effects or immunogenicity.The next generation of biopharmaceuticals can pose specific chemistry, manufacturing, and control (CMC) challenges. In contrast to conventional proteins, next-generation biopharmaceuticals often require lyophilization of the final drug product to ensure storage stability over shelf-life time. In addition, next-generation biopharmaceuticals require analytical methods that cover different ways of possible degradation patterns and pathways, and product development is a long way from being straight forward. The element of "prior knowledge" does not exist equally for most novel formats compared to antibodies, and thus the assessment of critical quality attributes (CQAs) and the definition of CQA assessment criteria and specifications is difficult, especially in early-stage development.

  5. Friend Finder (Game)

    Science.gov (United States)

    ... for a spot on the Friend Finder All-Star List. Earn your spot by showing you're savvy when it comes to making friends online . Downloads Please download and share our ... Email Updates Blog Feed Facebook YouTube Twitter The Federal Trade Commission (FTC) is the ...

  6. NASA's Next Generation Space Geodesy Network

    Science.gov (United States)

    Desai, S. D.; Gross, R. S.; Hilliard, L.; Lemoine, F. G.; Long, J. L.; Ma, C.; McGarry, J. F.; Merkowitz, S. M.; Murphy, D.; Noll, C. E.; hide

    2012-01-01

    NASA's Space Geodesy Project (SGP) is developing a prototype core site for a next generation Space Geodetic Network (SGN). Each of the sites in this planned network co-locate current state-of-the-art stations from all four space geodetic observing systems, GNSS, SLR, VLBI, and DORIS, with the goal of achieving modern requirements for the International Terrestrial Reference Frame (ITRF). In particular, the driving ITRF requirements for this network are 1.0 mm in accuracy and 0.1 mm/yr in stability, a factor of 10-20 beyond current capabilities. Development of the prototype core site, located at NASA's Geophysical and Astronomical Observatory at the Goddard Space Flight Center, started in 2011 and will be completed by the end of 2013. In January 2012, two operational GNSS stations, GODS and GOON, were established at the prototype site within 100 m of each other. Both stations are being proposed for inclusion into the IGS network. In addition, work is underway for the inclusion of next generation SLR and VLBI stations along with a modern DORIS station. An automated survey system is being developed to measure inter-technique vectorties, and network design studies are being performed to define the appropriate number and distribution of these next generation space geodetic core sites that are required to achieve the driving ITRF requirements. We present the status of this prototype next generation space geodetic core site, results from the analysis of data from the established geodetic stations, and results from the ongoing network design studies.

  7. Next Generation Solar Collectors for CSP

    Energy Technology Data Exchange (ETDEWEB)

    Molnar, Attila [3M Company, St. Paul, MN (United States); Charles, Ruth [3M Company, St. Paul, MN (United States)

    2014-07-31

    The intent of “Next Generation Solar Collectors for CSP” program was to develop key technology elements for collectors in Phase 1 (Budget Period 1), design these elements in Phase 2 (Budget Period 2) and to deploy and test the final collector in Phase 3 (Budget Period 3). 3M and DOE mutually agreed to terminate the program at the end of Budget Period 1, primarily due to timeline issues. However, significant advancements were achieved in developing a next generation reflective material and panel that has the potential to significantly improve the efficiency of CSP systems.

  8. Centroid vetting of transiting planet candidates from the Next Generation Transit Survey

    Science.gov (United States)

    Günther, Maximilian N.; Queloz, Didier; Gillen, Edward; McCormac, James; Bayliss, Daniel; Bouchy, Francois; Walker, Simon. R.; West, Richard G.; Eigmüller, Philipp; Smith, Alexis M. S.; Armstrong, David J.; Burleigh, Matthew; Casewell, Sarah L.; Chaushev, Alexander P.; Goad, Michael R.; Grange, Andrew; Jackman, James; Jenkins, James S.; Louden, Tom; Moyano, Maximiliano; Pollacco, Don; Poppenhaeger, Katja; Rauer, Heike; Raynard, Liam; Thompson, Andrew P. G.; Udry, Stéphane; Watson, Christopher A.; Wheatley, Peter J.

    2017-11-01

    The Next Generation Transit Survey (NGTS), operating in Paranal since 2016, is a wide-field survey to detect Neptunes and super-Earths transiting bright stars, which are suitable for precise radial velocity follow-up and characterization. Thereby, its sub-mmag photometric precision and ability to identify false positives are crucial. Particularly, variable background objects blended in the photometric aperture frequently mimic Neptune-sized transits and are costly in follow-up time. These objects can best be identified with the centroiding technique: if the photometric flux is lost off-centre during an eclipse, the flux centroid shifts towards the centre of the target star. Although this method has successfully been employed by the Kepler mission, it has previously not been implemented from the ground. We present a fully automated centroid vetting algorithm developed for NGTS, enabled by our high-precision autoguiding. Our method allows detecting centroid shifts with an average precision of 0.75 milli-pixel (mpix), and down to 0.25 mpix for specific targets, for a pixel size of 4.97 arcsec. The algorithm is now part of the NGTS candidate vetting pipeline and automatically employed for all detected signals. Further, we develop a joint Bayesian fitting model for all photometric and centroid data, allowing to disentangle which object (target or background) is causing the signal, and what its astrophysical parameters are. We demonstrate our method on two NGTS objects of interest. These achievements make NGTS the first ground-based wide-field transit survey ever to successfully apply the centroiding technique for automated candidate vetting, enabling the production of a robust candidate list before follow-up.

  9. Next generation PWR

    International Nuclear Information System (INIS)

    Tanaka, Toshihiko; Fukuda, Toshihiko; Usui, Shuji

    2001-01-01

    Development of LWR for power generation in Japan has been intended to upgrade its reliability, safety, operability, maintenance and economy as well as to increase its capacity in order, since nuclear power generation for commercial use was begun on 1970, to steadily increase its generation power. And, in Japan, ABWR (advanced BWR) of the most promising LWR in the world, was already used actually and APWR (advanced PWR) with the largest output in the world is also at a step of its actual use. And, development of the APWR in Japan was begun on 1980s, and is at a step of plan on construction of its first machine at early of this century. However, by large change of social affairs, economy of nuclear power generation is extremely required, to be positioned at an APWR improved development reactor promoted by collaboration of five PWR generation companies and the Mitsubishi Electric Co., Ltd. Therefore, on its development, investigation on effect of change in social affairs on nuclear power stations was at first carried out, to establish a design requirement for the next generation PWR. Here were described on outline, reactor core design, safety concept, and safety evaluation of APWR+ and development of an innovative PWR. (G.K.)

  10. The hardware track finder processor in CMS at CERN

    International Nuclear Information System (INIS)

    Kluge, A.

    1997-07-01

    The work covers the design of the Track Finder Processor in the high energy experiment CMS at CERN/Geneva. The task of this processor is to identify muons and to measure their transverse momentum. The Track Finder makes it possible to determine the physical relevance of each high energetic collision and to forward only interesting data to the data analysis units. Data of more than two hundred thousand detector cells are used to determine the location of muons and to measure their transverse momentum. Each 25 ns a new data set is generated. Measurement of location and transverse momentum of the muons can be terminated within 350 ns by using an ASIC. The classical method in high energy physics experiments is to employ a pattern comparison method. The predefined patterns are compared to the found patterns. The high number of data channels and the complex requirements to the spatial detector resolution do not permit to employ a pattern comparison method. A so called track following algorithm was designed, which is able to assemble complete tracks through the whole detector starting from single track segments. Instead of storing a high number of track patterns the problem is brought back to the algorithm level. Comprehensive simulations, employing the hardware simulation language VHDL, were conducted in order to optimize the algorithm and its hardware implementation. A FPGA (field program able gate array)-prototype was designed. A feasibility study to implement the track finder processor employing ASICs was conducted. (author)

  11. Thermal Development Test of the NEXT PM1 Ion Engine

    Science.gov (United States)

    Anderson, John R.; Snyder, John S.; VanNoord, Jonathan L.; Soulas, George C.

    2010-01-01

    NASA's Evolutionary Xenon Thruster (NEXT) is a next-generation high-power ion propulsion system under development by NASA as a part of the In-Space Propulsion Technology Program. NEXT is designed for use on robotic exploration missions of the solar system using solar electric power. Potential mission destinations that could benefit from a NEXT Solar Electric Propulsion (SEP) system include inner planets, small bodies, and outer planets and their moons. This range of robotic exploration missions generally calls for ion propulsion systems with deep throttling capability and system input power ranging from 0.6 to 25 kW, as referenced to solar array output at 1 Astronomical Unit (AU). Thermal development testing of the NEXT prototype model 1 (PM1) was conducted at JPL to assist in developing and validating a thruster thermal model and assessing the thermal design margins. NEXT PM1 performance prior to, during and subsequent to thermal testing are presented. Test results are compared to the predicted hot and cold environments expected missions and the functionality of the thruster for these missions is discussed.

  12. Filled aperture concepts for the Terrestrial Planet Finder

    Science.gov (United States)

    Ridgway, Stephen T.

    2003-02-01

    Filled aperture telescopes can deliver a real, high Strehl image which is well suited for discrimination of faint planets in the vicinity of bright stars and against an extended exo-zodiacal light. A filled aperture offers a rich variety of PSF control and diffraction suppression techniques. Filled apertures are under consideration for a wide spectral range, including visible and thermal-IR, each of which offers a significant selection of biomarker molecular bands. A filled aperture visible TPF may be simpler in several respects than a thermal-IR nuller. The required aperture size (or baseline) is much smaller, and no cryogenic systems are required. A filled aperture TPF would look and act like a normal telescope - vendors and users alike would be comfortable with its design and operation. Filled aperture telescopes pose significant challenges in production of large primary mirrors, and in very stringent wavefront requirements. Stability of the wavefront control, and hence of the PSF, is a major issue for filled aperture systems. Several groups have concluded that these and other issues can be resolved, and that filled aperture options are competitive for a TPF precursor and/or for the full TPF mission. Ball, Boeing-SVS and TRW have recently returned architecture reviews on filled aperture TPF concepts. In this paper, I will review some of the major considerations underlying these filled aperture concepts, and suggest key issues in a TPF Buyers Guide.

  13. Real-Time Optimization and Control of Next-Generation Distribution

    Science.gov (United States)

    -Generation Distribution Infrastructure Real-Time Optimization and Control of Next-Generation Distribution developing a system-theoretic distribution network management framework that unifies real-time voltage and Infrastructure | Grid Modernization | NREL Real-Time Optimization and Control of Next

  14. Hacking the next generation

    CERN Document Server

    Dhanjani, Nitesh; Hardin, Brett

    2009-01-01

    With the advent of rich Internet applications, the explosion of social media, and the increased use of powerful cloud computing infrastructures, a new generation of attackers has added cunning new techniques to its arsenal. For anyone involved in defending an application or a network of systems, Hacking: The Next Generation is one of the few books to identify a variety of emerging attack vectors. You'll not only find valuable information on new hacks that attempt to exploit technical flaws, you'll also learn how attackers take advantage of individuals via social networking sites, and abuse

  15. The NASA Next Generation Stirling Technology Program Overview

    Science.gov (United States)

    Schreiber, J. G.; Shaltens, R. K.; Wong, W. A.

    2005-12-01

    NASAs Science Mission Directorate is developing the next generation Stirling technology for future Radioisotope Power Systems (RPS) for surface and deep space missions. The next generation Stirling convertor is one of two advanced power conversion technologies currently being developed for future NASA missions, and is capable of operating for both planetary atmospheres and deep space environments. The Stirling convertor (free-piston engine integrated with a linear alternator) produces about 90 We(ac) and has a specific power of about 90 We/kg. Operating conditions of Thot at 850 degree C and Trej at 90 degree C results in the Stirling convertor estimated efficiency of about 40 per cent. Using the next generation Stirling convertor in future RPS, the "system" specific power is estimated at 8 We/kg. The design lifetime is three years on the surface of Mars and fourteen years in deep space missions. Electrical power of about 160 We (BOM) is produced by two (2) free-piston Stirling convertors heated by two (2) General Purpose Heat Source (GPHS) modules. This development is being performed by Sunpower, Athens, OH with Pratt & Whitney, Rocketdyne, Canoga Park, CA under contract to Glenn Research Center (GRC), Cleveland, Ohio. GRC is guiding the independent testing and technology development for the next generation Stirling generator.

  16. Rhamnolipids--next generation surfactants?

    Science.gov (United States)

    Müller, Markus Michael; Kügler, Johannes H; Henkel, Marius; Gerlitzki, Melanie; Hörmann, Barbara; Pöhnlein, Martin; Syldatk, Christoph; Hausmann, Rudolf

    2012-12-31

    The demand for bio-based processes and materials in the petrochemical industry has significantly increased during the last decade because of the expected running out of petroleum. This trend can be ascribed to three main causes: (1) the increased use of renewable resources for chemical synthesis of already established product classes, (2) the replacement of chemical synthesis of already established product classes by new biotechnological processes based on renewable resources, and (3) the biotechnological production of new molecules with new features or better performances than already established comparable chemically synthesized products. All three approaches are currently being pursued for surfactant production. Biosurfactants are a very promising and interesting substance class because they are based on renewable resources, sustainable, and biologically degradable. Alkyl polyglycosides are chemically synthesized biosurfactants established on the surfactant market. The first microbiological biosurfactants on the market were sophorolipids. Of all currently known biosurfactants, rhamnolipids have the highest potential for becoming the next generation of biosurfactants introduced on the market. Although the metabolic pathways and genetic regulation of biosynthesis are known qualitatively, the quantitative understanding relevant for bioreactor cultivation is still missing. Additionally, high product titers have been exclusively described with vegetable oil as sole carbon source in combination with Pseudomonas aeruginosa strains. Competitive productivity is still out of reach for heterologous hosts or non-pathogenic natural producer strains. Thus, on the one hand there is a need to gain a deeper understanding of the regulation of rhamnolipid production on process and cellular level during bioreactor cultivations. On the other hand, there is a need for metabolizable renewable substrates, which do not compete with food and feed. A sustainable bioeconomy approach should

  17. Physical Configuration of the Next Generation Home Network

    Science.gov (United States)

    Terada, Shohei; Kakishima, Yu; Hanawa, Dai; Oguchi, Kimio

    The number of broadband users is rapidly increasing worldwide. Japan already has over 10 million FTTH users. Another trend is the rapid digitalization of home electrical equipment e. g. digital cameras and hard disc recorders. These trends will encourage the emergence of the next generation home network. In this paper, we introduce the next generation home network image and describe the five domains into which home devices can be classified. We then clarify the optimum medium with which to configure the network given the requirements imposed by the home environment. Wiring cable lengths for three network topologies are calculated. The results gained from the next generation home network implemented on the first phase testbed are shown. Finally, our conclusions are given.

  18. Python Leap Second Management and Implementation of Precise Barycentric Correction (barycorrpy)

    Science.gov (United States)

    Kanodia, Shubham; Wright, Jason

    2018-01-01

    We announce barycorrpy (BCPy) , a Python implementation to calculate precise barycentric corrections well below the 1 cm/s level, following the algorithm of Wright and Eastman (2014). This level of precision is required in the search for 1 Earth mass planets in the Habitable Zones of Sun-like stars by the Radial Velocity (RV) method, where the maximum semi-amplitude is about 9 cm/s. We have developed BCPy to be used in the pipeline for the next generation Doppler Spectrometers - Habitable-zone Planet Finder (HPF) and NEID. In this work, we also develop an automated leap second management routine to improve upon the one available in Astropy. It checks for and downloads a new leap second file before converting from the UT time scale to TDB.

  19. Next generation vaccines.

    Science.gov (United States)

    Riedmann, Eva M

    2011-07-01

    In February this year, about 100 delegates gathered for three days in Vienna (Austria) for the Next Generation Vaccines conference. The meeting held in the Vienna Hilton Hotel from 23rd-25th February 2011 had a strong focus on biotech and industry. The conference organizer Jacob Fleming managed to put together a versatile program ranging from the future generation of vaccines to manufacturing, vaccine distribution and delivery, to regulatory and public health issues. Carefully selected top industry experts presented first-hand experience and shared solutions for overcoming the latest challenges in the field of vaccinology. The program also included several case study presentations on novel vaccine candidates in different stages of development. An interactive pre-conference workshop as well as interactive panel discussions during the meeting allowed all delegates to gain new knowledge and become involved in lively discussions on timely, interesting and sometimes controversial topics related to vaccines.

  20. Study of beauty quark production and next-to-leading order at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Nuncio Quiroz, Adriana Elizabeth

    2008-08-15

    In this thesis a study on the production and evolution of beauty quarks in ep collisions at HERA is presented. The emphasis is put on the corresponding Quantum Chromodynamics predictions including next-to-leading order corrections. In the context of this work the FMNR x Pythia interface was developed, which calculates next-to-leading order Quantum Chromodynamics predictions at visible level for heavy-flavour processes in the photoproduction regime. This is achieved using the RedStat routines which transform the FMNR program into a Monte Carlo-like event generator. The parton-level events obtained are interfaced to Pythia using the Le Houches accord routines. All branching ratios and decay channels of the heavy quarks implemented in the Pythia framework are used, and therefore complex cuts on the nal state can be applied. The FMNR x Pythia interface is applied in this thesis to obtain next-to-leading order predictions for the recently finished heavy flavour ZEUS analyses: the ep {yields} b anti bX {yields} D{sup *}{mu}X' and ep {yields} b anti bX {yields} {mu}{sup +}{mu}{sup -}X' channels. A comparison with the H1 D{sup *}{mu} measurement is also performed. Since the use of such double tagging techniques to identify events where heavy flavours are present proved to be very convenient when the nal state is a pair of leptons, another part of this thesis work deals with the implementation of an electron finder, the {sup G}Elec finder. This finder is tested on the reconstruction of the J/{psi} {yields} e{sup +}e{sup -} signal. Finally, a heavy-flavour analysis has been started, namely the ep {yields} b anti bX {yields} e{mu}X' dilepton channel, using an integrated luminosity of 114 pb{sup -1} gated by the ZEUS detector in the years 1996-2000. Compared to previous analyses the study of beauty quark production in this channel extends the phase space of the measurement closer to the kinematic threshold, since electrons provide access to lower p{sub T} values

  1. NOAA NEXt-Generation RADar (NEXRAD) Products

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset consists of Level III weather radar products collected from Next-Generation Radar (NEXRAD) stations located in the contiguous United States, Alaska,...

  2. The Next Generation Science Standards

    Science.gov (United States)

    Pruitt, Stephen L.

    2015-01-01

    The Next Generation Science Standards (NGSS Lead States 2013) were released almost two years ago. Work tied to the NGSS, their adoption, and implementation continues to move forward around the country. Stephen L. Pruitt, senior vice president, science, at Achieve, an independent, nonpartisan, nonprofit education reform organization that was a lead…

  3. The Next Generation Transit Survey (NGTS)

    Science.gov (United States)

    Wheatley, Peter J.; West, Richard G.; Goad, Michael R.; Jenkins, James S.; Pollacco, Don L.; Queloz, Didier; Rauer, Heike; Udry, Stéphane; Watson, Christopher A.; Chazelas, Bruno; Eigmüller, Philipp; Lambert, Gregory; Genolet, Ludovic; McCormac, James; Walker, Simon; Armstrong, David J.; Bayliss, Daniel; Bento, Joao; Bouchy, François; Burleigh, Matthew R.; Cabrera, Juan; Casewell, Sarah L.; Chaushev, Alexander; Chote, Paul; Csizmadia, Szilárd; Erikson, Anders; Faedi, Francesca; Foxell, Emma; Gänsicke, Boris T.; Gillen, Edward; Grange, Andrew; Günther, Maximilian N.; Hodgkin, Simon T.; Jackman, James; Jordán, Andrés; Louden, Tom; Metrailler, Lionel; Moyano, Maximiliano; Nielsen, Louise D.; Osborn, Hugh P.; Poppenhaeger, Katja; Raddi, Roberto; Raynard, Liam; Smith, Alexis M. S.; Soto, Maritza; Titz-Weider, Ruth

    2018-04-01

    We describe the Next Generation Transit Survey (NGTS), which is a ground-based project searching for transiting exoplanets orbiting bright stars. NGTS builds on the legacy of previous surveys, most notably WASP, and is designed to achieve higher photometric precision and hence find smaller planets than have previously been detected from the ground. It also operates in red light, maximizing sensitivity to late K and early M dwarf stars. The survey specifications call for photometric precision of 0.1 per cent in red light over an instantaneous field of view of 100 deg2, enabling the detection of Neptune-sized exoplanets around Sun-like stars and super-Earths around M dwarfs. The survey is carried out with a purpose-built facility at Cerro Paranal, Chile, which is the premier site of the European Southern Observatory (ESO). An array of twelve 20 cm f/2.8 telescopes fitted with back-illuminated deep-depletion CCD cameras is used to survey fields intensively at intermediate Galactic latitudes. The instrument is also ideally suited to ground-based photometric follow-up of exoplanet candidates from space telescopes such as TESS, Gaia and PLATO. We present observations that combine precise autoguiding and the superb observing conditions at Paranal to provide routine photometric precision of 0.1 per cent in 1 h for stars with I-band magnitudes brighter than 13. We describe the instrument and data analysis methods as well as the status of the survey, which achieved first light in 2015 and began full-survey operations in 2016. NGTS data will be made publicly available through the ESO archive.

  4. 47 CFR 80.289 - Requirements for radio direction finder.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Requirements for radio direction finder. 80.289... Requirements for radio direction finder. (a) The radio direction finding apparatus must: (1) Be capable of...) Possess a sensitivity, sufficient to permit the taking of bearings on a signal having a field strength of...

  5. Pharmacokinetic and pharmacodynamic considerations for the next generation protein therapeutics.

    Science.gov (United States)

    Shah, Dhaval K

    2015-10-01

    Increasingly sophisticated protein engineering efforts have been undertaken lately to generate protein therapeutics with desired properties. This has resulted in the discovery of the next generation of protein therapeutics, which include: engineered antibodies, immunoconjugates, bi/multi-specific proteins, antibody mimetic novel scaffolds, and engineered ligands/receptors. These novel protein therapeutics possess unique physicochemical properties and act via a unique mechanism-of-action, which collectively makes their pharmacokinetics (PK) and pharmacodynamics (PD) different than other established biological molecules. Consequently, in order to support the discovery and development of these next generation molecules, it becomes important to understand the determinants controlling their PK/PD. This review discusses the determinants that a PK/PD scientist should consider during the design and development of next generation protein therapeutics. In addition, the role of systems PK/PD models in enabling rational development of the next generation protein therapeutics is emphasized.

  6. IPv6: The Next Generation Internet Protocol

    Indian Academy of Sciences (India)

    addressing, new generation internet. 2. ... required the creation of the next generation of Internet ... IPv6 standards have defined the following Extension headers ..... addresses are represented as x:x:x:x:x:x:x:x, where each x is the hexadecimal ...

  7. Next-generation wireless technologies 4G and beyond

    CERN Document Server

    Chilamkurti, Naveen; Chaouchi, Hakima

    2013-01-01

    This comprehensive text/reference examines the various challenges to secure, efficient and cost-effective next-generation wireless networking. Topics and features: presents the latest advances, standards and technical challenges in a broad range of emerging wireless technologies; discusses cooperative and mesh networks, delay tolerant networks, and other next-generation networks such as LTE; examines real-world applications of vehicular communications, broadband wireless technologies, RFID technology, and energy-efficient wireless communications; introduces developments towards the 'Internet o

  8. Negotiation of Legitimacy of Witch-Finders in Lusaka

    Directory of Open Access Journals (Sweden)

    Mildnerová Kateřina

    2017-12-01

    Full Text Available The article aims at legal and illegal activities of Lusaka´s traditional healers within the system of traditional medicine which is primarily anchored in the constitution of traditional healers´ associations. It primarily focuses on witch-finders, whose social status, professional position and authority is constantly negotiated within the formal and informal sector of traditional medicine. Since the late 1990s, the quest for services of traditional healers specialised in witch-finding has gained popularity, particularly amongst the impoverished Lusaka compound-dwellers. Due to the increasing public violence against those denoted as witches, the activities of witch-finders were officially banned by the Witchcraft Act in 1995 and this profession is not officially recognised by the Constitution of Traditional Health Practitioners Association of Zambia (THAPAZ. In spite of the prohibition, there remain many witch-finders in Lusaka who practise witch-finding secretly, in order not to commit an offence they do not openly denounce the name of an alleged witch. Their authority and credibility is threatened by many “official” as well as “unofficial” competitors in the city and it must be constantly reaffirmed and negotiated by introducing innovations. The ability to keep clients and to gain a good reputation thus depends on the originality of their diagnostic and therapeutic procedures. At the same time witch-finders must counter diverse obstacles and uncertainties resulting from their illegal status within the sector of traditional medicine. The author analyses tactics that Lusaka´s witch-finders have developed and employed to negotiate their social status, credibility and authority visà-vis the competition from the “official” traditional healers.

  9. Study of beauty quark production and next-to-leading order effects at HERA

    International Nuclear Information System (INIS)

    Nuncio Quiroz, Adriana Elizabeth

    2008-08-01

    In this thesis a study on the production and evolution of beauty quarks in ep collisions at HERA is presented. The emphasis is put on the corresponding Quantum Chromodynamics predictions including next-to-leading order corrections. In the context of this work the FMNR x Pythia interface was developed, which calculates next-to-leading order Quantum Chromodynamics predictions at visible level for heavy-flavour processes in the photoproduction regime. This is achieved using the RedStat routines which transform the FMNR program into a Monte Carlo-like event generator. The parton-level events obtained are interfaced to Pythia using the Le Houches accord routines. All branching ratios and decay channels of the heavy quarks implemented in the Pythia framework are used, and therefore complex cuts on the nal state can be applied. The FMNR x Pythia interface is applied in this thesis to obtain next-to-leading order predictions for the recently finished heavy flavour ZEUS analyses: the ep → b anti bX → D * μX' and ep → b anti bX → μ + μ - X' channels. A comparison with the H1 D * μ measurement is also performed. Since the use of such double tagging techniques to identify events where heavy flavours are present proved to be very convenient when the nal state is a pair of leptons, another part of this thesis work deals with the implementation of an electron finder, the G Elec finder. This finder is tested on the reconstruction of the J/ψ → e + e - signal. Finally, a heavy-flavour analysis has been started, namely the ep → b anti bX → eμX' dilepton channel, using an integrated luminosity of 114 pb -1 gated by the ZEUS detector in the years 1996-2000. Compared to previous analyses the study of beauty quark production in this channel extends the phase space of the measurement closer to the kinematic threshold, since electrons provide access to lower p T values than muons do. The technical part of this thesis consisted in the calibration, maintenance and data

  10. Twitter Finder

    OpenAIRE

    Gil Blazquez, Lander

    2016-01-01

    La aplicación web a desarrollar se llama Twitter Finder. Se trata de una página web en la que cabe destacar como partes más importantes un buscador y un mapa. El usuario podrá hacer búsquedas de una o varias palabras clave a través del buscador. Con la búsqueda realizada y con la ayuda de la API de Twitter, se obtendrán los últimos tweets escritos que contengan el texto de la búsqueda,almacenándolos en la base de datos.

  11. Fault finder

    Science.gov (United States)

    Bunch, Richard H.

    1986-01-01

    A fault finder for locating faults along a high voltage electrical transmission line. Real time monitoring of background noise and improved filtering of input signals is used to identify the occurrence of a fault. A fault is detected at both a master and remote unit spaced along the line. A master clock synchronizes operation of a similar clock at the remote unit. Both units include modulator and demodulator circuits for transmission of clock signals and data. All data is received at the master unit for processing to determine an accurate fault distance calculation.

  12. Next Generation of Photovoltaics New Concepts

    CERN Document Server

    Vega, Antonio; López, Antonio

    2012-01-01

    This book presents new concepts for a next generation of PV. Among these concepts are: Multijunction solar cells, multiple excitation solar cells (or how to take benefit of high energy photons for the creation of more than one electron hole-pair), intermediate band solar cells (or how to take advantage of below band-gap energy photons) and related technologies (for quantum dots, nitrides, thin films), advanced light management approaches (plasmonics). Written by world-class experts in next generation photovoltaics this book is an essential reference guide accessible to both beginners and experts working with solar cell technology. The book deeply analyzes the current state-of-the-art of the new photovoltaic approaches and outlines the implementation paths of these advanced devices. Topics addressed range from the fundamentals to the description of state-of-the-art of the new types of solar cells.

  13. Next generation biofuel engineering in prokaryotes

    Science.gov (United States)

    Gronenberg, Luisa S.; Marcheschi, Ryan J.; Liao, James C.

    2014-01-01

    Next-generation biofuels must be compatible with current transportation infrastructure and be derived from environmentally sustainable resources that do not compete with food crops. Many bacterial species have unique properties advantageous to the production of such next-generation fuels. However, no single species possesses all characteristics necessary to make high quantities of fuels from plant waste or CO2. Species containing a subset of the desired characteristics are used as starting points for engineering organisms with all desired attributes. Metabolic engineering of model organisms has yielded high titer production of advanced fuels, including alcohols, isoprenoids and fatty acid derivatives. Technical developments now allow engineering of native fuel producers, as well as lignocellulolytic and autotrophic bacteria, for the production of biofuels. Continued research on multiple fronts is required to engineer organisms for truly sustainable and economical biofuel production. PMID:23623045

  14. Next generation of photovoltaics. New concepts

    Energy Technology Data Exchange (ETDEWEB)

    Cristobal Lopez, Ana Belen; Marti Vega, Antonio; Luque Lopez, Antonio (eds.) [Univ. Politecnica de Madrid (Spain). Inst. de Energia Solar E.T.S.I. Telecomunicacion

    2012-07-01

    This book presents new concepts for a next generation of PV. Among these concepts are: Multijunction solar cells, multiple excitation solar cells (or how to take benefit of high energy photons for the creation of more than one electron hole-pair), intermediate band solar cells (or how to take advantage of below band-gap energy photons) and related technologies (for quantum dots, nitrides, thin films), advanced light management approaches (plasmonics). Written by world-class experts in next generation photovoltaics this book is an essential reference guide accessible to both beginners and experts working with solar cell technology. The book deeply analyzes the current state-of-the-art of the new photovoltaic approaches and outlines the implementation paths of these advanced devices. Topics addressed range from the fundamentals to the description of state-of-the-art of the new types of solar cells. (orig.)

  15. Galaxy LIMS for next-generation sequencing

    NARCIS (Netherlands)

    Scholtalbers, J.; Rossler, J.; Sorn, P.; Graaf, J. de; Boisguerin, V.; Castle, J.; Sahin, U.

    2013-01-01

    SUMMARY: We have developed a laboratory information management system (LIMS) for a next-generation sequencing (NGS) laboratory within the existing Galaxy platform. The system provides lab technicians standard and customizable sample information forms, barcoded submission forms, tracking of input

  16. Next-generation Digital Earth.

    Science.gov (United States)

    Goodchild, Michael F; Guo, Huadong; Annoni, Alessandro; Bian, Ling; de Bie, Kees; Campbell, Frederick; Craglia, Max; Ehlers, Manfred; van Genderen, John; Jackson, Davina; Lewis, Anthony J; Pesaresi, Martino; Remetey-Fülöpp, Gábor; Simpson, Richard; Skidmore, Andrew; Wang, Changlin; Woodgate, Peter

    2012-07-10

    A speech of then-Vice President Al Gore in 1998 created a vision for a Digital Earth, and played a role in stimulating the development of a first generation of virtual globes, typified by Google Earth, that achieved many but not all the elements of this vision. The technical achievements of Google Earth, and the functionality of this first generation of virtual globes, are reviewed against the Gore vision. Meanwhile, developments in technology continue, the era of "big data" has arrived, the general public is more and more engaged with technology through citizen science and crowd-sourcing, and advances have been made in our scientific understanding of the Earth system. However, although Google Earth stimulated progress in communicating the results of science, there continue to be substantial barriers in the public's access to science. All these factors prompt a reexamination of the initial vision of Digital Earth, and a discussion of the major elements that should be part of a next generation.

  17. Special Issue: Next Generation DNA Sequencing

    Directory of Open Access Journals (Sweden)

    Paul Richardson

    2010-10-01

    Full Text Available Next Generation Sequencing (NGS refers to technologies that do not rely on traditional dideoxy-nucleotide (Sanger sequencing where labeled DNA fragments are physically resolved by electrophoresis. These new technologies rely on different strategies, but essentially all of them make use of real-time data collection of a base level incorporation event across a massive number of reactions (on the order of millions versus 96 for capillary electrophoresis for instance. The major commercial NGS platforms available to researchers are the 454 Genome Sequencer (Roche, Illumina (formerly Solexa Genome analyzer, the SOLiD system (Applied Biosystems/Life Technologies and the Heliscope (Helicos Corporation. The techniques and different strategies utilized by these platforms are reviewed in a number of the papers in this special issue. These technologies are enabling new applications that take advantage of the massive data produced by this next generation of sequencing instruments. [...

  18. Next-Generation Sequencing of Tubal Intraepithelial Carcinomas.

    Science.gov (United States)

    McDaniel, Andrew S; Stall, Jennifer N; Hovelson, Daniel H; Cani, Andi K; Liu, Chia-Jen; Tomlins, Scott A; Cho, Kathleen R

    2015-11-01

    High-grade serous carcinoma (HGSC) is the most prevalent and lethal form of ovarian cancer. HGSCs frequently arise in the distal fallopian tubes rather than the ovary, developing from small precursor lesions called serous tubal intraepithelial carcinomas (TICs, or more specifically, STICs). While STICs have been reported to harbor TP53 mutations, detailed molecular characterizations of these lesions are lacking. We performed targeted next-generation sequencing (NGS) on formalin-fixed, paraffin-embedded tissue from 4 women, 2 with HGSC and 2 with uterine endometrioid carcinoma (UEC) who were diagnosed as having synchronous STICs. We detected concordant mutations in both HGSCs with synchronous STICs, including TP53 mutations as well as assumed germline BRCA1/2 alterations, confirming a clonal association between these lesions. Next-generation sequencing confirmed the presence of a STIC clonally unrelated to 1 case of UEC, and NGS of the other tubal lesion diagnosed as a STIC unexpectedly supported the lesion as a micrometastasis from the associated UEC. We demonstrate that targeted NGS can identify genetic alterations in minute lesions, such as TICs, and confirm TP53 mutations as early driving events for HGSC. Next-generation sequencing also demonstrated unexpected associations between presumed STICs and synchronous carcinomas, providing evidence that some TICs are actually metastases rather than HGSC precursors.

  19. Next Generation NASA Initiative for Space Geodesy

    Science.gov (United States)

    Merkowitz, S. M.; Desai, S.; Gross, R. S.; Hilliard, L.; Lemoine, F. G.; Long, J. L.; Ma, C.; McGarry J. F.; Murphy, D.; Noll, C. E.; hide

    2012-01-01

    Space geodesy measurement requirements have become more and more stringent as our understanding of the physical processes and our modeling techniques have improved. In addition, current and future spacecraft will have ever-increasing measurement capability and will lead to increasingly sophisticated models of changes in the Earth system. Ground-based space geodesy networks with enhanced measurement capability will be essential to meeting these oncoming requirements and properly interpreting the sate1!ite data. These networks must be globally distributed and built for longevity, to provide the robust data necessary to generate improved models for proper interpretation ofthe observed geophysical signals. These requirements have been articulated by the Global Geodetic Observing System (GGOS). The NASA Space Geodesy Project (SGP) is developing a prototype core site as the basis for a next generation Space Geodetic Network (SGN) that would be NASA's contribution to a global network designed to produce the higher quality data required to maintain the Terrestrial Reference Frame and provide information essential for fully realizing the measurement potential of the current and coming generation of Earth Observing spacecraft. Each of the sites in the SGN would include co-located, state of-the-art systems from all four space geodetic observing techniques (GNSS, SLR, VLBI, and DORIS). The prototype core site is being developed at NASA's Geophysical and Astronomical Observatory at Goddard Space Flight Center. The project commenced in 2011 and is scheduled for completion in late 2013. In January 2012, two multiconstellation GNSS receivers, GODS and GODN, were established at the prototype site as part of the local geodetic network. Development and testing are also underway on the next generation SLR and VLBI systems along with a modern DORIS station. An automated survey system is being developed to measure inter-technique vector ties, and network design studies are being

  20. Next-generation fiber lasers enabled by high-performance components

    Science.gov (United States)

    Kliner, D. A. V.; Victor, B.; Rivera, C.; Fanning, G.; Balsley, D.; Farrow, R. L.; Kennedy, K.; Hampton, S.; Hawke, R.; Soukup, E.; Reynolds, M.; Hodges, A.; Emery, J.; Brown, A.; Almonte, K.; Nelson, M.; Foley, B.; Dawson, D.; Hemenway, D. M.; Urbanek, W.; DeVito, M.; Bao, L.; Koponen, J.; Gross, K.

    2018-02-01

    Next-generation industrial fiber lasers enable challenging applications that cannot be addressed with legacy fiber lasers. Key features of next-generation fiber lasers include robust back-reflection protection, high power stability, wide power tunability, high-speed modulation and waveform generation, and facile field serviceability. These capabilities are enabled by high-performance components, particularly pump diodes and optical fibers, and by advanced fiber laser designs. We summarize the performance and reliability of nLIGHT diodes, fibers, and next-generation industrial fiber lasers at power levels of 500 W - 8 kW. We show back-reflection studies with up to 1 kW of back-reflected power, power-stability measurements in cw and modulated operation exhibiting sub-1% stability over a 5 - 100% power range, and high-speed modulation (100 kHz) and waveform generation with a bandwidth 20x higher than standard fiber lasers. We show results from representative applications, including cutting and welding of highly reflective metals (Cu and Al) for production of Li-ion battery modules and processing of carbon fiber reinforced polymers.

  1. Optimization high vortex finder of cyclone separator with computational fluids dynamics simulation

    Directory of Open Access Journals (Sweden)

    Ni Ketut Caturwati

    2017-01-01

    Full Text Available Cyclone separator is an equipment that separates particles contained in the fluid without using filters. The dust particles in the flue gases can be separated by utilizing centrifugal forces and different densities of particles, so that the exhaust gases to be cleaner before discharged into the environment. In this paper carried out a simulation by Computational of Fluids Dynamics to determine the number of particles that can be separated in several cyclone separator which has a ratio body diameter against vortex finder high varied as : 1:0.5 ; 1:0.75 ; 1:1 ; 1:1.25 and 1:1.5. Fluid inlet are air with antrachite impurity particles that are commonly found in the exhaust gases from tire manufacturers with inlet velocities varied as: 15 m/s and 30 m/s. The results of simulation show the fluids with 15 m/s of inlet velocity is generate particle separation value is higher than the fluids with 30 m/s inlet velocity for ratio of body diameter and height vortex finder a: 1:0.5 and 1:1.5. For both of inlet velocities the best ratio of body diameter and height vortex finder is 1:1.25, where it has the highest values of percentage trapped particles about 86% for 30 m/s input velocity and also for 15 m/s input velocity.

  2. Physical and Mathematical Questions on Signal Processing in Multibase Phase Direction Finders

    Science.gov (United States)

    Denisov, V. P.; Dubinin, D. V.; Meshcheryakov, A. A.

    2018-02-01

    Questions on improving the accuracy of multiple-base phase direction finders by rejecting anomalously large errors in the process of resolving the measurement ambiguities are considered. A physical basis is derived and calculated relationships characterizing the efficiency of the proposed solutions are obtained. Results of a computer simulation of a three-base direction finder are analyzed, along with field measurements of a three-base direction finder along near-ground paths.

  3. AugerNext: innovative research studies for the next generation ground-based ultra-high energy cosmic ray experiment

    Directory of Open Access Journals (Sweden)

    Haungs Andreas

    2013-06-01

    Full Text Available The findings so far of the Pierre Auger Observatory and also of the Telescope Array define the requirements for a possible next generation experiment: it needs to be considerably increased in size, it needs a better sensitivity to composition, and it should cover the full sky. AugerNext aims to perform innovative research studies in order to prepare a proposal fulfilling these demands. Such R&D studies are primarily focused in the following areas iconsolidation of the detection of cosmic rays using MHz radio antennas; iiproof-of-principle of cosmic-ray microwave detection; iiitest of the large-scale application of a new generation photo-sensors; ivgeneralization of data communication techniques; vdevelopment of new ways of muon detection with surface arrays. These AugerNext studies on new innovative detection methods for a next generation cosmic-ray experiment are performed at the Pierre Auger Observatory. The AugerNext consortium consists presently of fourteen partner institutions from nine European countries supported by a network of European funding agencies and it is a principal element of the ASPERA/ApPEC strategic roadmaps.

  4. A Comprehensive Radial Velocity Error Budget for Next Generation Doppler Spectrometers

    Science.gov (United States)

    Halverson, Samuel; Ryan, Terrien; Mahadevan, Suvrath; Roy, Arpita; Bender, Chad; Stefansson, Guomundur Kari; Monson, Andrew; Levi, Eric; Hearty, Fred; Blake, Cullen; hide

    2016-01-01

    We describe a detailed radial velocity error budget for the NASA-NSF Extreme Precision Doppler Spectrometer instrument concept NEID (NN-explore Exoplanet Investigations with Doppler spectroscopy). Such an instrument performance budget is a necessity for both identifying the variety of noise sources currently limiting Doppler measurements, and estimating the achievable performance of next generation exoplanet hunting Doppler spectrometers. For these instruments, no single source of instrumental error is expected to set the overall measurement floor. Rather, the overall instrumental measurement precision is set by the contribution of many individual error sources. We use a combination of numerical simulations, educated estimates based on published materials, extrapolations of physical models, results from laboratory measurements of spectroscopic subsystems, and informed upper limits for a variety of error sources to identify likely sources of systematic error and construct our global instrument performance error budget. While natively focused on the performance of the NEID instrument, this modular performance budget is immediately adaptable to a number of current and future instruments. Such an approach is an important step in charting a path towards improving Doppler measurement precisions to the levels necessary for discovering Earth-like planets.

  5. MobilomeFINDER: web-based tools for in silico and experimental discovery of bacterial genomic islands

    Science.gov (United States)

    Ou, Hong-Yu; He, Xinyi; Harrison, Ewan M.; Kulasekara, Bridget R.; Thani, Ali Bin; Kadioglu, Aras; Lory, Stephen; Hinton, Jay C. D.; Barer, Michael R.; Rajakumar, Kumar

    2007-01-01

    MobilomeFINDER (http://mml.sjtu.edu.cn/MobilomeFINDER) is an interactive online tool that facilitates bacterial genomic island or ‘mobile genome’ (mobilome) discovery; it integrates the ArrayOme and tRNAcc software packages. ArrayOme utilizes a microarray-derived comparative genomic hybridization input data set to generate ‘inferred contigs’ produced by merging adjacent genes classified as ‘present’. Collectively these ‘fragments’ represent a hypothetical ‘microarray-visualized genome (MVG)’. ArrayOme permits recognition of discordances between physical genome and MVG sizes, thereby enabling identification of strains rich in microarray-elusive novel genes. Individual tRNAcc tools facilitate automated identification of genomic islands by comparative analysis of the contents and contexts of tRNA sites and other integration hotspots in closely related sequenced genomes. Accessory tools facilitate design of hotspot-flanking primers for in silico and/or wet-science-based interrogation of cognate loci in unsequenced strains and analysis of islands for features suggestive of foreign origins; island-specific and genome-contextual features are tabulated and represented in schematic and graphical forms. To date we have used MobilomeFINDER to analyse several Enterobacteriaceae, Pseudomonas aeruginosa and Streptococcus suis genomes. MobilomeFINDER enables high-throughput island identification and characterization through increased exploitation of emerging sequence data and PCR-based profiling of unsequenced test strains; subsequent targeted yeast recombination-based capture permits full-length sequencing and detailed functional studies of novel genomic islands. PMID:17537813

  6. New materials for next-generation commercial transports

    National Research Council Canada - National Science Library

    Committee on New Materials for Advanced Civil Aircraft, Commission on Engineering and Technical Systems, National Research Council

    ... civil aircraft throughout their service life. The committee investigated the new materials and structural concepts that are likely to be incorporated into next generation commercial aircraft and the factors influencing application decisions...

  7. Preparation of next generation set of group cross sections. 3

    International Nuclear Information System (INIS)

    Kaneko, Kunio

    2002-03-01

    This fiscal year, based on the examination result about the evaluation energy range of heavy element unresolved resonance cross sections, the upper energy limit of the energy range, where ultra-fine group cross sections are produced, was raised to 50 keV, and an improvement of the group cross section processing system was promoted. At the same time, reflecting the result of studies carried out till now, a function producing delayed neutron data was added to the general-purpose group cross section processing system , thus the preparation of general purpose group cross section processing system has been completed. On the other hand, the energy structure, data constitution and data contents of next generation group cross section set were determined, and the specification of a 151 groups next generation group cross section set was defined. Based on the above specification, a concrete library format of the next generation cross section set has been determined. After having carried out the above-described work, using the general-purpose group cross section processing system , which was complete in this study, with use of the JENDL-3. 2 evaluated nuclear data, the 151 groups next generation group cross section of 92 nuclides and the ultra fine group resonance cross section library for 29 nuclides have been prepared. Utilizing the 151 groups next generation group cross section set and the ultra-fine group resonance cross-section library, a bench mark test calculation of fast reactors has been performed by using an advanced lattice calculation code. It was confirmed, by comparing the calculation result with a calculation result of continuous energy Monte Carlo code, that the 151 groups next generation cross section set has sufficient accuracy. (author)

  8. Implementing the Next Generation Science Standards

    Science.gov (United States)

    Penuel, William R.; Harris, Christopher J.; DeBarger, Angela Haydel

    2015-01-01

    The Next Generation Science Standards embody a new vision for science education grounded in the idea that science is both a body of knowledge and a set of linked practices for developing knowledge. The authors describe strategies that they suggest school and district leaders consider when designing strategies to support NGSS implementation.

  9. Next-Generation Sequencing Platforms

    Science.gov (United States)

    Mardis, Elaine R.

    2013-06-01

    Automated DNA sequencing instruments embody an elegant interplay among chemistry, engineering, software, and molecular biology and have built upon Sanger's founding discovery of dideoxynucleotide sequencing to perform once-unfathomable tasks. Combined with innovative physical mapping approaches that helped to establish long-range relationships between cloned stretches of genomic DNA, fluorescent DNA sequencers produced reference genome sequences for model organisms and for the reference human genome. New types of sequencing instruments that permit amazing acceleration of data-collection rates for DNA sequencing have been developed. The ability to generate genome-scale data sets is now transforming the nature of biological inquiry. Here, I provide an historical perspective of the field, focusing on the fundamental developments that predated the advent of next-generation sequencing instruments and providing information about how these instruments work, their application to biological research, and the newest types of sequencers that can extract data from single DNA molecules.

  10. Unbundling in Current Broadband and Next-Generation Ultra-Broadband Access Networks

    Science.gov (United States)

    Gaudino, Roberto; Giuliano, Romeo; Mazzenga, Franco; Valcarenghi, Luca; Vatalaro, Francesco

    2014-05-01

    This article overviews the methods that are currently under investigation for implementing multi-operator open-access/shared-access techniques in next-generation access ultra-broadband architectures, starting from the traditional "unbundling-of-the-local-loop" techniques implemented in legacy twisted-pair digital subscriber line access networks. A straightforward replication of these copper-based unbundling-of-the-local-loop techniques is usually not feasible on next-generation access networks, including fiber-to-the-home point-to-multipoint passive optical networks. To investigate this issue, the article first gives a concise description of traditional copper-based unbundling-of-the-local-loop solutions, then focalizes on both next-generation access hybrid fiber-copper digital subscriber line fiber-to-the-cabinet scenarios and on fiber to the home by accounting for the mix of regulatory and technological reasons driving the next-generation access migration path, focusing mostly on the European situation.

  11. Space based microlensing planet searches

    Directory of Open Access Journals (Sweden)

    Tisserand Patrick

    2013-04-01

    Full Text Available The discovery of extra-solar planets is arguably the most exciting development in astrophysics during the past 15 years, rivalled only by the detection of dark energy. Two projects unite the communities of exoplanet scientists and cosmologists: the proposed ESA M class mission EUCLID and the large space mission WFIRST, top ranked by the Astronomy 2010 Decadal Survey report. The later states that: “Space-based microlensing is the optimal approach to providing a true statistical census of planetary systems in the Galaxy, over a range of likely semi-major axes”. They also add: “This census, combined with that made by the Kepler mission, will determine how common Earth-like planets are over a wide range of orbital parameters”. We will present a status report of the results obtained by microlensing on exoplanets and the new objectives of the next generation of ground based wide field imager networks. We will finally discuss the fantastic prospect offered by space based microlensing at the horizon 2020–2025.

  12. Mobile e-Learning for Next Generation Communication Environment

    Science.gov (United States)

    Wu, Tin-Yu; Chao, Han-Chieh

    2008-01-01

    This article develops an environment for mobile e-learning that includes an interactive course, virtual online labs, an interactive online test, and lab-exercise training platform on the fourth generation mobile communication system. The Next Generation Learning Environment (NeGL) promotes the term "knowledge economy." Inter-networking…

  13. A Window Into Clinical Next-Generation Sequencing-Based Oncology Testing Practices.

    Science.gov (United States)

    Nagarajan, Rakesh; Bartley, Angela N; Bridge, Julia A; Jennings, Lawrence J; Kamel-Reid, Suzanne; Kim, Annette; Lazar, Alexander J; Lindeman, Neal I; Moncur, Joel; Rai, Alex J; Routbort, Mark J; Vasalos, Patricia; Merker, Jason D

    2017-12-01

    - Detection of acquired variants in cancer is a paradigm of precision medicine, yet little has been reported about clinical laboratory practices across a broad range of laboratories. - To use College of American Pathologists proficiency testing survey results to report on the results from surveys on next-generation sequencing-based oncology testing practices. - College of American Pathologists proficiency testing survey results from more than 250 laboratories currently performing molecular oncology testing were used to determine laboratory trends in next-generation sequencing-based oncology testing. - These presented data provide key information about the number of laboratories that currently offer or are planning to offer next-generation sequencing-based oncology testing. Furthermore, we present data from 60 laboratories performing next-generation sequencing-based oncology testing regarding specimen requirements and assay characteristics. The findings indicate that most laboratories are performing tumor-only targeted sequencing to detect single-nucleotide variants and small insertions and deletions, using desktop sequencers and predesigned commercial kits. Despite these trends, a diversity of approaches to testing exists. - This information should be useful to further inform a variety of topics, including national discussions involving clinical laboratory quality systems, regulation and oversight of next-generation sequencing-based oncology testing, and precision oncology efforts in a data-driven manner.

  14. Next-generation mammalian genetics toward organism-level systems biology.

    Science.gov (United States)

    Susaki, Etsuo A; Ukai, Hideki; Ueda, Hiroki R

    2017-01-01

    Organism-level systems biology in mammals aims to identify, analyze, control, and design molecular and cellular networks executing various biological functions in mammals. In particular, system-level identification and analysis of molecular and cellular networks can be accelerated by next-generation mammalian genetics. Mammalian genetics without crossing, where all production and phenotyping studies of genome-edited animals are completed within a single generation drastically reduce the time, space, and effort of conducting the systems research. Next-generation mammalian genetics is based on recent technological advancements in genome editing and developmental engineering. The process begins with introduction of double-strand breaks into genomic DNA by using site-specific endonucleases, which results in highly efficient genome editing in mammalian zygotes or embryonic stem cells. By using nuclease-mediated genome editing in zygotes, or ~100% embryonic stem cell-derived mouse technology, whole-body knock-out and knock-in mice can be produced within a single generation. These emerging technologies allow us to produce multiple knock-out or knock-in strains in high-throughput manner. In this review, we discuss the basic concepts and related technologies as well as current challenges and future opportunities for next-generation mammalian genetics in organism-level systems biology.

  15. Predictions of Planet Detections with Near-infrared Radial Velocities in the Upcoming SPIRou Legacy Survey-planet Search

    Science.gov (United States)

    Cloutier, Ryan; Artigau, Étienne; Delfosse, Xavier; Malo, Lison; Moutou, Claire; Doyon, René; Donati, Jean-Francois; Cumming, Andrew; Dumusque, Xavier; Hébrard, Élodie; Menou, Kristen

    2018-02-01

    The SPIRou near-infrared spectropolarimeter is destined to begin science operations at the Canada–France–Hawaii Telescope in mid-2018. One of the instrument’s primary science goals is to discover the closest exoplanets to the solar system by conducting a three- to five-year long radial velocity survey of nearby M dwarfs at an expected precision of ∼1 m s‑1, the SPIRou Legacy Survey-Planet Search (SLS-PS). In this study, we conduct a detailed Monte Carlo simulation of the SLS-PS using our current understanding of the occurrence rate of M dwarf planetary systems and physical models of stellar activity. From simultaneous modeling of planetary signals and activity, we predict the population of planets to be detected in the SLS-PS. With our fiducial survey strategy and expected instrument performance over a nominal survey length of ∼3 years, we expect SPIRou to detect {85.3}-12.4+29.3 planets including {20.0}-7.2+16.8 habitable-zone planets and {8.1}-3.2+7.6 Earth-like planets from a sample of 100 M1–M8.5 dwarfs out to 11 pc. By studying mid-to-late M dwarfs previously inaccessible to existing optical velocimeters, SPIRou will put meaningful constraints on the occurrence rate of planets around those stars including the value of {η }\\oplus at an expected level of precision of ≲ 45 % . We also predict that a subset of {46.7}-6.0+16.0 planets may be accessible with dedicated high-contrast imagers on the next generation of extremely large telescopes including {4.9}-2.0+4.7 potentially imagable Earth-like planets. Lastly, we compare the results of our fiducial survey strategy to other foreseeable survey versions to quantify which strategy is optimized to reach the SLS-PS science goals. The results of our simulations are made available to the community on GitHub (https://github.com/r-cloutier/SLSPS_Simulations).

  16. Towards Next Generation BI Systems

    DEFF Research Database (Denmark)

    Varga, Jovan; Romero, Oscar; Pedersen, Torben Bach

    2014-01-01

    Next generation Business Intelligence (BI) systems require integration of heterogeneous data sources and a strong user-centric orientation. Both needs entail machine-processable metadata to enable automation and allow end users to gain access to relevant data for their decision making processes....... This framework is based on the findings of a survey of current user-centric approaches mainly focusing on query recommendation assistance. Finally, we discuss the benefits of the framework and present the plans for future work....

  17. Data Analysis and Next Generation Assessments

    Science.gov (United States)

    Pon, Kathy

    2013-01-01

    For the last decade, much of the work of California school administrators has been shaped by the accountability of the No Child Left Behind Act. Now as they stand at the precipice of Common Core Standards and next generation assessments, it is important to reflect on the proficiency educators have attained in using data to improve instruction and…

  18. Achieving universal access to next generation networks

    DEFF Research Database (Denmark)

    Falch, Morten; Henten, Anders

    The paper examines investment dimensions of next generation networks in a universal service perspective in a European context. The question is how new network infrastructures for getting access to communication, information and entertainment services in the present and future information society...

  19. Next generation breeding.

    Science.gov (United States)

    Barabaschi, Delfina; Tondelli, Alessandro; Desiderio, Francesca; Volante, Andrea; Vaccino, Patrizia; Valè, Giampiero; Cattivelli, Luigi

    2016-01-01

    The genomic revolution of the past decade has greatly improved our understanding of the genetic make-up of living organisms. The sequencing of crop genomes has completely changed our vision and interpretation of genome organization and evolution. Re-sequencing allows the identification of an unlimited number of markers as well as the analysis of germplasm allelic diversity based on allele mining approaches. High throughput marker technologies coupled with advanced phenotyping platforms provide new opportunities for discovering marker-trait associations which can sustain genomic-assisted breeding. The availability of genome sequencing information is enabling genome editing (site-specific mutagenesis), to obtain gene sequences desired by breeders. This review illustrates how next generation sequencing-derived information can be used to tailor genomic tools for different breeders' needs to revolutionize crop improvement. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  20. Direct Imaging of Warm Extrasolar Planets

    International Nuclear Information System (INIS)

    Macintosh, B

    2005-01-01

    field of young-star identification, we carried out a systematic near-infrared search for young planetary companions to ∼200 young stars. We also carried out targeted high-sensitivity observations of selected stars surrounded by circumstellar dust rings. We developed advanced image processing techniques to allow detection of even fainter sources buried in the noisy halo of scattered starlight. Even with these techniques, around most of our targets our search was only sensitive to planets in orbits significantly wider than our solar system. With some carefully selected targets--very young dusty stars in the solar neighborhood--we reach sensitivities sufficient to see solar systems like our own. Although we discovered no unambiguous planets, we can significantly constrain the frequency of such planets in wide (>50 AU) orbits, which helps determine which models of planet formation remain plausible. Successful modeling of our observations has led us to the design of a next-generation AO system that will truly be capable of exploring solar systems resembling our own

  1. Next-Generation Sequencing: From Understanding Biology to Personalized Medicine

    Directory of Open Access Journals (Sweden)

    Benjamin Meder

    2013-03-01

    Full Text Available Within just a few years, the new methods for high-throughput next-generation sequencing have generated completely novel insights into the heritability and pathophysiology of human disease. In this review, we wish to highlight the benefits of the current state-of-the-art sequencing technologies for genetic and epigenetic research. We illustrate how these technologies help to constantly improve our understanding of genetic mechanisms in biological systems and summarize the progress made so far. This can be exemplified by the case of heritable heart muscle diseases, so-called cardiomyopathies. Here, next-generation sequencing is able to identify novel disease genes, and first clinical applications demonstrate the successful translation of this technology into personalized patient care.

  2. THE PROJECT: an Observatory / Transport Spaceship for Discovering and Populating Habitable Extrasolar Terrestrial Planets

    Science.gov (United States)

    Kilston, S.

    1998-12-01

    Recent extrasolar planet discoveries and related progress in astrophysics have refined our knowledge of the implications of the Drake equation. The Space Interferometry Mission and the planned Terrestrial Planet Finder will deepen this understanding, and begin pointing the way to places we need to explore at closer range. If the correct resolution of the Fermi paradox regarding intelligent extraterrestrials (``where are they?") is found to lie in the actual scarcity of such beings, it may turn out that we are more advanced than most other life-forms in our galaxy. In this case, a main purpose in finding planets may be to find places for us to go: astronomy will once again play a major role in human navigation and migration. We describe a strawman design concept for an astronomical observatory ship designed for launch beyond our solar system within several hundred years. This ship design would employ plausible physics, biology, technology, sociology, and economics to carry one million passengers in a one-G environment shielded from space radiation. A cruising speed under 0.01 c, slower than in many science-fiction concepts, minimizes power requirements and the danger from collisional impacts. The ship would contain all subsystems needed to sustain multi-generational life on a voyage of thousands of years, as well as the observatories to identify for human settlement a habitable extrasolar planet. Even the modestly advanced technology described here could spread intelligent life throughout our galaxy within 40 million years, a very small fraction of the galaxy's age. Motivation for such an ambitious project is three-fold: expanding our knowledge of the universe, enlisting the efforts and enthusiasms of humankind toward a very grand goal which will stimulate progress in all aspects of our cultures and technologies, and participating in the process of spreading life so its survivability and fruition are enhanced.

  3. Next Generation Drivetrain Development and Test Program

    Energy Technology Data Exchange (ETDEWEB)

    Keller, Jonathan; Erdman, Bill; Blodgett, Doug; Halse, Chris; Grider, Dave

    2015-11-03

    This presentation was given at the Wind Energy IQ conference in Bremen, Germany, November 30 through December 2, 2105. It focused on the next-generation drivetrain architecture and drivetrain technology development and testing (including gearbox and inverter software and medium-voltage inverter modules.

  4. Heterogeneous next-generation wireless network interference model-and its applications

    KAUST Repository

    Mahmood, Nurul Huda

    2014-04-01

    Next-generation wireless systems facilitating better utilisation of the scarce radio spectrum have emerged as a response to inefficient and rigid spectrum assignment policies. These are comprised of intelligent radio nodes that opportunistically operate in the radio spectrum of existing primary systems, yet unwanted interference at the primary receivers is unavoidable. In order to design efficient next-generation systems and to minimise the adverse effect of their interference, it is necessary to realise how the resulting interference impacts the performance of the primary systems. In this work, a generalised framework for the interference analysis of such a next-generation system is presented where the nextgeneration transmitters may transmit randomly with different transmit powers. The analysis is built around a model developed for the statistical representation of the interference at the primary receivers, which is then used to evaluate various performance measures of the primary system. Applications of the derived interference model in designing the next-generation network system parameters are also demonstrated. Such approach provides a unified and generalised framework, the use of which allows a wide range of performance metrics can be evaluated. Findings of the analytical performance analyses are confirmed through extensive computer-based Monte-Carlo simulations. © 2012 John Wiley & Sons, Ltd.

  5. RxnFinder: biochemical reaction search engines using molecular structures, molecular fragments and reaction similarity.

    Science.gov (United States)

    Hu, Qian-Nan; Deng, Zhe; Hu, Huanan; Cao, Dong-Sheng; Liang, Yi-Zeng

    2011-09-01

    Biochemical reactions play a key role to help sustain life and allow cells to grow. RxnFinder was developed to search biochemical reactions from KEGG reaction database using three search criteria: molecular structures, molecular fragments and reaction similarity. RxnFinder is helpful to get reference reactions for biosynthesis and xenobiotics metabolism. RxnFinder is freely available via: http://sdd.whu.edu.cn/rxnfinder. qnhu@whu.edu.cn.

  6. 76 FR 49776 - The Development and Evaluation of Next-Generation Smallpox Vaccines; Public Workshop

    Science.gov (United States)

    2011-08-11

    ...] The Development and Evaluation of Next-Generation Smallpox Vaccines; Public Workshop AGENCY: Food and... Evaluation of Next-Generation Smallpox Vaccines.'' The purpose of the public workshop is to identify and discuss the key issues related to the development and evaluation of next-generation smallpox vaccines. The...

  7. Comparison of three multiplex PCR assays for the detection of respiratory viral infections: evaluation of xTAG respiratory virus panel fast assay, RespiFinder 19 assay and RespiFinder SMART 22 assay

    Directory of Open Access Journals (Sweden)

    Dabisch-Ruthe Mareike

    2012-07-01

    Full Text Available Abstract Background A broad spectrum of pathogens is causative for respiratory tract infections, but symptoms are mostly similar. Therefore, the identification of the causative viruses and bacteria is only feasible using multiplex PCR or several monoplex PCR tests in parallel. Methods The analytical sensitivity of three multiplex PCR assays, RespiFinder-19, RespiFinder-SMART-22 and xTAG-Respiratory-Virus-Panel-Fast-Assay (RVP, were compared to monoplex real-time PCR with quantified standardized control material. All assays include the most common respiratory pathogens. Results To compare the analytical sensitivity of the multiplex assays, samples were inoculated with 13 different quantified viruses in the range of 101 to 105 copies/ml. Concordant results were received for rhinovirus, whereas the RVP detected influenzavirus, RSV and hMPV more frequently in low concentrations. The RespiFinder-19 and the RespiFinder-SMART-22 showed a higher analytical sensitivity for adenoviruses and coronaviruses, whereas the RVP was incapable to detect adenovirus and coronavirus in concentrations of 104 copies/ml. The RespiFinder-19 and RespiFinder-SMART-22A did not detect influenzaviruses (104 copies/ml and RSV (103 copies/ml. The detection of all 13 viruses in one sample was only achieved using monoplex PCR. To analyze possible competitive amplification reactions between the different viruses, samples were further inoculated with only 4 different viruses in one sample. Compared to the detection of 13 viruses in parallel, only a few differences were found. The incidence of respiratory viruses was compared in tracheal secretion (TS samples (n = 100 of mechanically ventilated patients in winter (n = 50 and summer (n = 50. In winter, respiratory viruses were detected in 32 TS samples (64% by RespiFinder-19, whereas the detection rate with RVP was only 22%. The most frequent viruses were adenovirus (32% and PIV-2 (20%. Multiple infections were detected

  8. Applications of nanotechnology, next generation sequencing and microarrays in biomedical research.

    Science.gov (United States)

    Elingaramil, Sauli; Li, Xiaolong; He, Nongyue

    2013-07-01

    Next-generation sequencing technologies, microarrays and advances in bio nanotechnology have had an enormous impact on research within a short time frame. This impact appears certain to increase further as many biomedical institutions are now acquiring these prevailing new technologies. Beyond conventional sampling of genome content, wide-ranging applications are rapidly evolving for next-generation sequencing, microarrays and nanotechnology. To date, these technologies have been applied in a variety of contexts, including whole-genome sequencing, targeted re sequencing and discovery of transcription factor binding sites, noncoding RNA expression profiling and molecular diagnostics. This paper thus discusses current applications of nanotechnology, next-generation sequencing technologies and microarrays in biomedical research and highlights the transforming potential these technologies offer.

  9. Next generation surveillance system (NGSS)

    International Nuclear Information System (INIS)

    Aparo, Massimo

    2006-01-01

    Development of 'functional requirements' for transparency systems may offer a near-term mode of regional cooperation. New requirements under development at the IAEA may provide a foundation for this potential activity. The Next Generation Surveillance System (NGSS) will become the new IAEA remote monitoring system Under new requirements the NGSS would attempt to use more commercial components to reduce cost, increase radiation survivability and further increase reliability. The NGSS must be available in two years due to rapidly approaching obsolescence in the existing DCM family. (author)

  10. Predicting the Atmospheric Composition of Extrasolar Giant Planets

    Science.gov (United States)

    Sharp, A. G.; Moses, J. I.; Friedson, A. J.; Fegley, B., Jr.; Marley, M. S.; Lodders, K.

    2004-01-01

    To date, approximately 120 planet-sized objects have been discovered around other stars, mostly through the radial-velocity technique. This technique can provide information about a planet s minimum mass and its orbital period and distance; however, few other planetary data can be obtained at this point in time unless we are fortunate enough to find an extrasolar giant planet that transits its parent star (i.e., the orbit is edge-on as seen from Earth). In that situation, many physical properties of the planet and its parent star can be determined, including some compositional information. Our prospects of directly obtaining spectra from extrasolar planets may improve in the near future, through missions like NASA's Terrestrial Planet Finder. Most of the extrasolar giant planets (EGPs) discovered so far have masses equal to or greater than Jupiter's mass, and roughly 16% have orbital radii less than 0.1 AU - extremely close to the parent star by our own Solar-System standards (note that Mercury is located at a mean distance of 0.39 AU and Jupiter at 5.2 AU from the Sun). Although all EGPs are expected to have hydrogen-dominated atmospheres similar to Jupiter, the orbital distance can strongly affect the planet's temperature, physical, chemical, and spectral properties, and the abundance of minor, detectable atmospheric constituents. Thermochemical equilibrium models can provide good zero-order predictions for the atmospheric composition of EGPs. However, both the composition and spectral properties will depend in large part on disequilibrium processes like photochemistry, chemical kinetics, atmospheric transport, and haze formation. We have developed a photochemical kinetics, radiative transfer, and 1-D vertical transport model to study the atmospheric composition of EGPs. The chemical reaction list contains H-, C-, O-, and N-bearing species and is designed to be valid for atmospheric temperatures ranging from 100-3000 K and pressures up to 50 bar. Here we examine

  11. Optimizing the next generation optical access networks

    DEFF Research Database (Denmark)

    Amaya Fernández, Ferney Orlando; Soto, Ana Cardenas; Tafur Monroy, Idelfonso

    2009-01-01

    Several issues in the design and optimization of the next generation optical access network (NG-OAN) are presented. The noise, the distortion and the fiber optic nonlinearities are considered to optimize the video distribution link in a passive optical network (PON). A discussion of the effect...

  12. IPv6: The Next Generation Internet Protocol

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 3. IPv6: The Next Generation Internet Protocol - IPv4 and its Shortcomings. Harsha Srinath. General Article Volume 8 Issue 3 March 2003 pp 33-41. Fulltext. Click here to view fulltext PDF. Permanent link:

  13. IPv6: The Next Generation Internet Protocol

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 4. IPv6: The Next Generation Internet Protocol - New Features in IPv6. Harsha Srinath. General Article Volume 8 Issue 4 April 2003 pp 8-16. Fulltext. Click here to view fulltext PDF. Permanent link:

  14. Next-Generation Sequencing for Binary Protein-Protein Interactions

    Directory of Open Access Journals (Sweden)

    Bernhard eSuter

    2015-12-01

    Full Text Available The yeast two-hybrid (Y2H system exploits host cell genetics in order to display binary protein-protein interactions (PPIs via defined and selectable phenotypes. Numerous improvements have been made to this method, adapting the screening principle for diverse applications, including drug discovery and the scale-up for proteome wide interaction screens in human and other organisms. Here we discuss a systematic workflow and analysis scheme for screening data generated by Y2H and related assays that includes high-throughput selection procedures, readout of comprehensive results via next-generation sequencing (NGS, and the interpretation of interaction data via quantitative statistics. The novel assays and tools will serve the broader scientific community to harness the power of NGS technology to address PPI networks in health and disease. We discuss examples of how this next-generation platform can be applied to address specific questions in diverse fields of biology and medicine.

  15. Next Generation Safeguards Initiative: Human Capital Development

    International Nuclear Information System (INIS)

    Scholz, M.; Irola, G.; Glynn, K.

    2015-01-01

    Since 2008, the Human Capital Development (HCD) subprogramme of the U.S. National Nuclear Security Administration's (NNSA) Next Generation Safeguards Initiative (NGSI) has supported the recruitment, education, training, and retention of the next generation of international safeguards professionals to meet the needs of both the International Atomic Energy Agency (IAEA) and the United States. Specifically, HCD's efforts respond to data indicating that 82% of safeguards experts at U.S. Laboratories will have left the workforce within 15 years. This paper provides an update on the status of the subprogramme since its last presentation at the IAEA Safeguards Symposium in 2010. It highlights strengthened, integrated efforts in the areas of graduate and post-doctoral fellowships, young and midcareer professional support, short safeguards courses, and university engagement. It also discusses lessons learned from the U.S. experience in safeguards education and training as well as the importance of long-range strategies to develop a cohesive, effective, and efficient human capital development approach. (author)

  16. Next Generation Sequencing of Ancient DNA: Requirements, Strategies and Perspectives

    Directory of Open Access Journals (Sweden)

    Michael Knapp

    2010-07-01

    Full Text Available The invention of next-generation-sequencing has revolutionized almost all fields of genetics, but few have profited from it as much as the field of ancient DNA research. From its beginnings as an interesting but rather marginal discipline, ancient DNA research is now on its way into the centre of evolutionary biology. In less than a year from its invention next-generation-sequencing had increased the amount of DNA sequence data available from extinct organisms by several orders of magnitude. Ancient DNA  research is now not only adding a temporal aspect to evolutionary studies and allowing for the observation of evolution in real time, it also provides important data to help understand the origins of our own species. Here we review progress that has been made in next-generation-sequencing of ancient DNA over the past five years and evaluate sequencing strategies and future directions.

  17. NOAA Next Generation Radar (NEXRAD) Level 3 Products

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset consists of Level 3 weather radar products collected from Next-Generation Radar (NEXRAD) stations located in the contiguous United States, Alaska,...

  18. PathogenFinder - Distinguishing Friend from Foe Using Bacterial Whole Genome Sequence Data

    DEFF Research Database (Denmark)

    Cosentino, Salvatore; Larsen, Mette Voldby; Aarestrup, Frank Møller

    2013-01-01

    approaches. We describe PathogenFinder (http://cge.cbs.dtu.dk/services/PathogenFinder/), a web-server for the prediction of bacterial pathogenicity by analysing the input proteome, genome, or raw reads provided by the user. The method relies on groups of proteins, created without regard to their annotated...

  19. Next generation sensors and systems

    CERN Document Server

    2016-01-01

    Written by experts in their area of research, this book has outlined the current status of the fundamentals and analytical concepts, modelling and design issues, technical details and practical applications of different types of sensors and discussed about the trends of next generation of sensors and systems happening in the area of Sensing technology. This book will be useful as a reference book for engineers and scientist especially the post-graduate students find will this book as reference book for their research on wearable sensors, devices and technologies.  .

  20. A Versatile Technique to Enable Sub-milli-Kelvin Instrument Stability for Precise Radial Velocity Measurements: Tests with the Habitable-zone Planet Finder

    Science.gov (United States)

    Stefansson, Gudmundur; Hearty, Frederick; Robertson, Paul; Mahadevan, Suvrath; Anderson, Tyler; Levi, Eric; Bender, Chad; Nelson, Matthew; Monson, Andrew; Blank, Basil; Halverson, Samuel; Henderson, Chuck; Ramsey, Lawrence; Roy, Arpita; Schwab, Christian; Terrien, Ryan

    2016-12-01

    Insufficient instrument thermomechanical stability is one of the many roadblocks for achieving 10 cm s-1 Doppler radial velocity precision, the precision needed to detect Earth-twins orbiting solar-type stars. Highly temperature and pressure stabilized spectrographs allow us to better calibrate out instrumental drifts, thereby helping in distinguishing instrumental noise from astrophysical stellar signals. We present the design and performance of the Environmental Control System (ECS) for the Habitable-zone Planet Finder (HPF), a high-resolution (R = 50,000) fiber-fed near-infrared (NIR) spectrograph for the 10 {{m}} Hobby-Eberly Telescope at McDonald Observatory. HPF will operate at 180 {{K}}, driven by the choice of an H2RG NIR detector array with a 1.7 μ {{m}} cutoff. This ECS has demonstrated 0.6 {mK} rms stability over 15 days at both 180 and 300 {{K}}, and maintained high-quality vacuum (\\lt {10}-7 {Torr}) over months, during long-term stability tests conducted without a planned passive thermal enclosure surrounding the vacuum chamber. This control scheme is versatile and can be applied as a blueprint to stabilize future NIR and optical high-precision Doppler instruments over a wide temperature range from ˜77 {{K}} to elevated room temperatures. A similar ECS is being implemented to stabilize NEID, the NASA/NSF NN-EXPLORE spectrograph for the 3.5 {{m}} WIYN telescope at Kitt Peak, operating at 300 {{K}}. A [full SolidWorks 3D-CAD model] and a comprehensive parts list of the HPF ECS are included with this manuscript to facilitate the adaptation of this versatile environmental control scheme in the broader astronomical community. Certain commercial equipment, instruments, or materials are identified in this paper in order to specify the experimental procedure adequately. Such identification is not intended to imply recommendation or endorsement by the National Institute of Standards and Technology, nor is it intended to imply that the materials or equipment

  1. Diagnostics of Primary Immunodeficiencies through Next Generation Sequencing

    Directory of Open Access Journals (Sweden)

    Vera Gallo

    2016-11-01

    Full Text Available Background: Recently, a growing number of novel genetic defects underlying primary immunodeficiencies (PID have been identified, increasing the number of PID up to more than 250 well-defined forms. Next-generation sequencing (NGS technologies and proper filtering strategies greatly contributed to this rapid evolution, providing the possibility to rapidly and simultaneously analyze large numbers of genes or the whole exome. Objective: To evaluate the role of targeted next-generation sequencing and whole exome sequencing in the diagnosis of a case series, characterized by complex or atypical clinical features suggesting a PID, difficult to diagnose using the current diagnostic procedures.Methods: We retrospectively analyzed genetic variants identified through targeted next-generation sequencing or whole exome sequencing in 45 patients with complex PID of unknown etiology. Results: 40 variants were identified using targeted next-generation sequencing, while 5 were identified using whole exome sequencing. Newly identified genetic variants were classified into 4 groups: I variations associated with a well-defined PID; II variations associated with atypical features of a well-defined PID; III functionally relevant variations potentially involved in the immunological features; IV non-diagnostic genotype, in whom the link with phenotype is missing. We reached a conclusive genetic diagnosis in 7/45 patients (~16%. Among them, 4 patients presented with a typical well-defined PID. In the remaining 3 cases, mutations were associated with unexpected clinical features, expanding the phenotypic spectrum of typical PIDs. In addition, we identified 31 variants in 10 patients with complex phenotype, individually not causative per se of the disorder.Conclusion: NGS technologies represent a cost-effective and rapid first-line genetic approaches for the evaluation of complex PIDs. Whole exome sequencing, despite a moderate higher cost compared to targeted, is

  2. LISA and LISA PathFinder, the endeavour to detect low frequency GWs

    Energy Technology Data Exchange (ETDEWEB)

    Araujo, H [Blackett Laboratory, Imperial College London, Prince Consort Road, London SW7 2BW (United Kingdom); Boatella, C [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Chmeissani, M [Institut de Fisica d' Altes Energies (IFAE), Edifici C, Universitat Autonoma de Barcelona, 08193 Bellaterra (Barcelona) (Spain); Conchillo, A [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Garcia-Berro, E [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Grimani, C [Universita degli Studi di Urbino, and INFN Florence, Istituto di Fisica, Via Santa Chiara 27, 61029 Urbino (Italy); Hajdas, W [Department of Particles and Matter, Paul Scherrer Institut, ODRA 120, 5232 Villigen (Switzerland); Lobo, A [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Martinez, L [AtIpic, Parc Tecnologic del Valles, 08290 Cerdanyola del Valles, Barcelona (Spain); Nofrarias, M [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Ortega, J A [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Puigdengoles, C [Institut de Fisica d' Altes Energies (IFAE), Edifici C, Universitat Autonoma de Barcelona, 08193 Bellaterra (Barcelona) (Spain); Ramos-Castro, J [Departament d' Enginyeria Electronica, UPC, Campus Nord, Edif. C4, Jordi Girona 1-3, 08034 Barcelona (Spain); Sanjuan, J [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Wass, P [Blackett Laboratory, Imperial College London, Prince Consort Road, London SW7 2BW (United Kingdom); Xirgu, X [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain)

    2007-05-15

    This is a review about LISA and its technology demonstrator, LISAPathFinder. We first describe the conceptual problems which need to be overcome in order to set up a working interferometric detector of low frequency Gravitational Waves (GW), then summarise the solutions to them as currently conceived by the LISA mission team. This will show that some of these solutions require new technological abilities which are still under development, and which need proper test before being fully implemented. LISAPathFinder (LPF) is the the testbed for such technologies. The final part of the paper will address the ideas and concepts behind the PathFinder as well as their impact on LISA.

  3. LISA and LISA PathFinder, the endeavour to detect low frequency GWs

    International Nuclear Information System (INIS)

    Araujo, H; Boatella, C; Chmeissani, M; Conchillo, A; Garcia-Berro, E; Grimani, C; Hajdas, W; Lobo, A; Martinez, L; Nofrarias, M; Ortega, J A; Puigdengoles, C; Ramos-Castro, J; Sanjuan, J; Wass, P; Xirgu, X

    2007-01-01

    This is a review about LISA and its technology demonstrator, LISAPathFinder. We first describe the conceptual problems which need to be overcome in order to set up a working interferometric detector of low frequency Gravitational Waves (GW), then summarise the solutions to them as currently conceived by the LISA mission team. This will show that some of these solutions require new technological abilities which are still under development, and which need proper test before being fully implemented. LISAPathFinder (LPF) is the the testbed for such technologies. The final part of the paper will address the ideas and concepts behind the PathFinder as well as their impact on LISA

  4. Parallel 4-dimensional cellular automaton track finder for the CBM experiment

    Energy Technology Data Exchange (ETDEWEB)

    Akishina, Valentina [Goethe-Universitaet Frankfurt am Main, Frankfurt am Main (Germany); Frankfurt Institute for Advanced Studies, Frankfurt am Main (Germany); GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Darmstadt (Germany); JINR Joint Institute for Nuclear Research, Dubna (Russian Federation); Kisel, Ivan [Goethe-Universitaet Frankfurt am Main, Frankfurt am Main (Germany); Frankfurt Institute for Advanced Studies, Frankfurt am Main (Germany); GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Darmstadt (Germany); Collaboration: CBM-Collaboration

    2016-07-01

    The CBM experiment at FAIR will focus on the measurement of rare probes at interaction rates up to 10 MHz. The beam will provide free stream of particles, so that information about different collisions may overlap in time. It requires the full online event reconstruction not only in space, but also in time, so-called 4D (4-dimensional) event building. This is a task of the First-Level Event Selection (FLES) package. The FLES reconstruction package consists of several modules: track finding, track fitting, short-lived particles finding, event building and selection. The Silicon Tracking System (STS) time measurement information was included into the Cellular Automaton (CA) track finder algorithm. The 4D track finder algorithm speed (8.5 ms per event in a time-slice) and efficiency is comparable with the event-based analysis. The CA track finder was fully parallelised inside the time-slice. The parallel version achieves a speed-up factor of 10.6 while parallelising between 10 Intel Xeon physical cores with a hyper-threading. The first version of event building based on 4D track finder was implemented.

  5. Examination of concept of next generation computer. Progress report 1999

    Energy Technology Data Exchange (ETDEWEB)

    Higuchi, Kenji; Hasegawa, Yukihiro; Hirayama, Toshio

    2000-12-01

    The Center for Promotion of Computational Science and Engineering has conducted R and D works on the technology of parallel processing and has started the examination of the next generation computer in 1999. This report describes the behavior analyses of quantum calculation codes. It also describes the consideration for the analyses and examination results for the method to reduce cash misses. Furthermore, it describes a performance simulator that is being developed to quantitatively examine the concept of the next generation computer. (author)

  6. Next-Generation Pathology.

    Science.gov (United States)

    Caie, Peter D; Harrison, David J

    2016-01-01

    The field of pathology is rapidly transforming from a semiquantitative and empirical science toward a big data discipline. Large data sets from across multiple omics fields may now be extracted from a patient's tissue sample. Tissue is, however, complex, heterogeneous, and prone to artifact. A reductionist view of tissue and disease progression, which does not take this complexity into account, may lead to single biomarkers failing in clinical trials. The integration of standardized multi-omics big data and the retention of valuable information on spatial heterogeneity are imperative to model complex disease mechanisms. Mathematical modeling through systems pathology approaches is the ideal medium to distill the significant information from these large, multi-parametric, and hierarchical data sets. Systems pathology may also predict the dynamical response of disease progression or response to therapy regimens from a static tissue sample. Next-generation pathology will incorporate big data with systems medicine in order to personalize clinical practice for both prognostic and predictive patient care.

  7. Potential of OFDM for next generation optical access

    Science.gov (United States)

    Fritzsche, Daniel; Weis, Erik; Breuer, Dirk

    2011-01-01

    This paper shows the requirements for next generation optical access (NGOA) networks and analyzes the potential of OFDM (orthogonal frequency division multiplexing) for the use in such network scenarios. First, we show the motivation for NGOA systems based on the future requirements on FTTH access systems and list the advantages of OFDM in such scenarios. In the next part, the basics of OFDM and different methods to generate and detect optical OFDM signals are explained and analyzed. At the transmitter side the options include intensity modulation and the more advanced field modulation of the optical OFDM signal. At the receiver there is the choice between direct detection and coherent detection. As the result of this discussion we show our vision of the future use of OFDM in optical access networks.

  8. Neutronics activities for next generation devices

    International Nuclear Information System (INIS)

    Gohar, Y.

    1985-01-01

    Neutronic activities for the next generation devices are the subject of this paper. The main activities include TFCX and FPD blanket/shield studies, neutronic aspects of ETR/INTOR critical issues, and neutronics computational modules for the tokamak system code and tandem mirror reactor system code. Trade-off analyses, optimization studies, design problem investigations and computational models development for reactor parametric studies carried out for these activities are summarized

  9. Imaging Planet Formation Inside the Diffraction Limit

    Science.gov (United States)

    Sallum, Stephanie Elise

    For decades, astronomers have used observations of mature planetary systems to constrain planet formation theories, beginning with our own solar system and now the thousands of known exoplanets. Recent advances in instrumentation have given us a direct view of some steps in the planet formation process, such as large-scale protostar and protoplanetary disk features and evolution. However, understanding the details of how planets accrete and interact with their environment requires direct observations of protoplanets themselves. Transition disks, protoplanetary disks with inner clearings that may be caused by forming planets, are the best targets for these studies. Their large distances, compared to the stars normally targeted for direct imaging of exoplanets, make protoplanet detection difficult and necessitate novel imaging techniques. In this dissertation, I describe the results of using non-redundant masking (NRM) to search for forming planets in transition disk clearings. I first present a data reduction pipeline that I wrote to this end, using example datasets and simulations to demonstrate reduction and imaging optimizations. I discuss two transition disk NRM case studies: T Cha and LkCa 15. In the case of T Cha, while we detect significant asymmetries, the data cannot be explained by orbiting companions. The fluxes and orbital motion of the LkCa 15 companion signals, however, can be naturally explained by protoplanets in the disk clearing. I use these datasets and simulated observations to illustrate the effects of scattered light from transition disk material on NRM protoplanet searches. I then demonstrate the utility of the dual-aperture Large Binocular Telescope Interferometer's NRM mode on the bright B[e] star MWC 349A. I discuss the implications of this work for planet formation studies as well as future prospects for NRM and related techniques on next generation instruments.

  10. THE TRAINING OF NEXT GENERATION DATA SCIENTISTS IN BIOMEDICINE.

    Science.gov (United States)

    Garmire, Lana X; Gliske, Stephen; Nguyen, Quynh C; Chen, Jonathan H; Nemati, Shamim; VAN Horn, John D; Moore, Jason H; Shreffler, Carol; Dunn, Michelle

    2017-01-01

    With the booming of new technologies, biomedical science has transformed into digitalized, data intensive science. Massive amount of data need to be analyzed and interpreted, demand a complete pipeline to train next generation data scientists. To meet this need, the transinstitutional Big Data to Knowledge (BD2K) Initiative has been implemented since 2014, complementing other NIH institutional efforts. In this report, we give an overview the BD2K K01 mentored scientist career awards, which have demonstrated early success. We address the specific trainings needed in representative data science areas, in order to make the next generation of data scientists in biomedicine.

  11. A two-stage flow-based intrusion detection model for next-generation networks.

    Science.gov (United States)

    Umer, Muhammad Fahad; Sher, Muhammad; Bi, Yaxin

    2018-01-01

    The next-generation network provides state-of-the-art access-independent services over converged mobile and fixed networks. Security in the converged network environment is a major challenge. Traditional packet and protocol-based intrusion detection techniques cannot be used in next-generation networks due to slow throughput, low accuracy and their inability to inspect encrypted payload. An alternative solution for protection of next-generation networks is to use network flow records for detection of malicious activity in the network traffic. The network flow records are independent of access networks and user applications. In this paper, we propose a two-stage flow-based intrusion detection system for next-generation networks. The first stage uses an enhanced unsupervised one-class support vector machine which separates malicious flows from normal network traffic. The second stage uses a self-organizing map which automatically groups malicious flows into different alert clusters. We validated the proposed approach on two flow-based datasets and obtained promising results.

  12. Radio resource management for next generation mobile communication systems

    DEFF Research Database (Denmark)

    Wang, Hua

    The key feature of next generation (4G) mobile communication system is the ability to deliver a variety of multimedia services with different Quality-of-Service (QoS) requirements. Compared to the third generation (3G) mobile communication systems, 4G mobile communication system introduces several...

  13. The challenge of electromobility in the next generation; Herausforderung Elektromobilitaet der naechsten Generation

    Energy Technology Data Exchange (ETDEWEB)

    Baeker, Bernard [Technische Univ. Dresden (Germany). Lehrstuhl Fahrzeugmechatronik

    2010-07-01

    Due to the actual energy and CO{sub 2} discussion the e-mobility approach comes more and more in the fore. In combination with renewable energy harvesting we get a real hype to solve entire sustainable and emission free future energy supply questions of this planet. This paper as a serious contribution therefore deals with real e-mobility scenarios for the masses with sustainability for an energy technology and energy political world consisting of an integrative approach for living and mobility in the future. Starting with the 100 years old history of electric drives and vehicles the background of an overall energy management from the energy provider to a distributed renewable energy production and corresponding mobility systems will be discussed. The outlook shows proposals and concrete solutions for next steps of a vehicle electrification (from the hybrid to the pure electric vehicle) and an intelligent networked energy supply. (orig.)

  14. Energy and luminosity requirements for the next generation of linear colliders

    International Nuclear Information System (INIS)

    Amaldi, U.

    1987-01-01

    In order to gain new knowledge ('new physics') from 'next generation' linear colliders energy and luminosity are important variables when considering the design of these new elementary particle probes. The standard model of the electroweak interaction is reviewed and stipulations for postulated Higgs particle, a new neutral Z particle, and a new quark and a neutral lepton searches with next generation colliders are given

  15. Dependable Hydrogen and Industrial Heat Generation from the Next Generation Nuclear Plant

    Energy Technology Data Exchange (ETDEWEB)

    Charles V. Park; Michael W. Patterson; Vincent C. Maio; Piyush Sabharwall

    2009-03-01

    The Department of Energy is working with industry to develop a next generation, high-temperature gas-cooled nuclear reactor (HTGR) as a part of the effort to supply the US with abundant, clean and secure energy. The Next Generation Nuclear Plant (NGNP) project, led by the Idaho National Laboratory, will demonstrate the ability of the HTGR to generate hydrogen, electricity, and high-quality process heat for a wide range of industrial applications. Substituting HTGR power for traditional fossil fuel resources reduces the cost and supply vulnerability of natural gas and oil, and reduces or eliminates greenhouse gas emissions. As authorized by the Energy Policy Act of 2005, industry leaders are developing designs for the construction of a commercial prototype producing up to 600 MWt of power by 2021. This paper describes a variety of critical applications that are appropriate for the HTGR with an emphasis placed on applications requiring a clean and reliable source of hydrogen. An overview of the NGNP project status and its significant technology development efforts are also presented.

  16. Perspectives on the development of next generation reactor systems safety analysis codes

    International Nuclear Information System (INIS)

    Zhang, H.

    2015-01-01

    'Full text:' Existing reactor system analysis codes, such as RELAP5-3D and TRAC, have gained worldwide success in supporting reactor safety analyses, as well as design and licensing of new reactors. These codes are important assets to the nuclear engineering research community, as well as to the nuclear industry. However, most of these codes were originally developed during the 1970s', and it becomes necessary to develop next-generation reactor system analysis codes for several reasons. Firstly, as new reactor designs emerge, there are new challenges emerging in numerical simulations of reactor systems such as long lasting transients and multi-physics phenomena. These new requirements are beyond the range of applicability of the existing system analysis codes. Advanced modeling and numerical methods must be taken into consideration to improve the existing capabilities. Secondly, by developing next-generation reactor system analysis codes, the knowledge (know how) in two phase flow modeling and the highly complex constitutive models will be transferred to the young generation of nuclear engineers. And thirdly, all computer codes have limited shelf life. It becomes less and less cost-effective to maintain a legacy code, due to the fast change of computer hardware and software environment. There are several critical perspectives in terms of developing next-generation reactor system analysis codes: 1) The success of the next-generation codes must be built upon the success of the existing codes. The knowledge of the existing codes, not just simply the manuals and codes, but knowing why and how, must be transferred to the next-generation codes. The next-generation codes should encompass the capability of the existing codes. The shortcomings of existing codes should be identified, understood, and properly categorized, for example into model deficiencies or numerical method deficiencies. 2) State-of-the-art models and numerical methods must be considered to

  17. Perspectives on the development of next generation reactor systems safety analysis codes

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, H., E-mail: Hongbin.Zhang@inl.gov [Idaho National Laboratory, Idaho Falls, ID (United States)

    2015-07-01

    'Full text:' Existing reactor system analysis codes, such as RELAP5-3D and TRAC, have gained worldwide success in supporting reactor safety analyses, as well as design and licensing of new reactors. These codes are important assets to the nuclear engineering research community, as well as to the nuclear industry. However, most of these codes were originally developed during the 1970s', and it becomes necessary to develop next-generation reactor system analysis codes for several reasons. Firstly, as new reactor designs emerge, there are new challenges emerging in numerical simulations of reactor systems such as long lasting transients and multi-physics phenomena. These new requirements are beyond the range of applicability of the existing system analysis codes. Advanced modeling and numerical methods must be taken into consideration to improve the existing capabilities. Secondly, by developing next-generation reactor system analysis codes, the knowledge (know how) in two phase flow modeling and the highly complex constitutive models will be transferred to the young generation of nuclear engineers. And thirdly, all computer codes have limited shelf life. It becomes less and less cost-effective to maintain a legacy code, due to the fast change of computer hardware and software environment. There are several critical perspectives in terms of developing next-generation reactor system analysis codes: 1) The success of the next-generation codes must be built upon the success of the existing codes. The knowledge of the existing codes, not just simply the manuals and codes, but knowing why and how, must be transferred to the next-generation codes. The next-generation codes should encompass the capability of the existing codes. The shortcomings of existing codes should be identified, understood, and properly categorized, for example into model deficiencies or numerical method deficiencies. 2) State-of-the-art models and numerical methods must be considered to

  18. RETRATAMENTO ENDODÔNTICO: ESTUDO COMPARATIVO ENTRE TÉCNICA MANUAL, ULTRA-SOM E CANAL FINDER ENDODONTIC RETREATMENT: COMPARATIVE STUDY BETWEEN MANUAL TECHNIQUE, ULTRASONIC SCALER, AND CANAL FINDER

    Directory of Open Access Journals (Sweden)

    Clovis Monteiro BRAMANTE

    1998-01-01

    Full Text Available Instrumentações manual, ultra-sônica e com Canal Finder foram utilizadas para retratamento de 30 dentes com canais obturados com guta-percha e óxido de zinco e eugenol. Avaliaram-se: 1. tempo gasto para a penetração inicial até o ápice; 2. tempo para completar a limpeza; 3. extrusão de material e 4. limpeza dos canais. O Canal Finder foi a técnica que propiciou melhor limpeza, seguida da manual e da ultra-sônica. A parede palatina do canal foi constantemente mais limpa do que a vestibular. Quanto à extrusão, a técnica de ultra-som foi a que propiciou mais extravasamento de material obturador.Endodontic retreatment of 30 teeth filled with guta percha and zinc oxide-eugenol was carried out using manual instrumentation, ultrasonic scaler, and the Canal Finder System. The following variables were evaluated: time spent to reach the apex; time spent to complete cleaning of the canal; apical extrusion of material; and cleanliness of the canals. Results showed the Canal Finder System as providing the highest level of cleanliness of the canal system; lingual walls were constantly cleaner than buccal walls; ultrasonic technique presented a greater degree of apical extrusion of filling material.

  19. Synchronization System for Next Generation Light Sources

    Energy Technology Data Exchange (ETDEWEB)

    Zavriyev, Anton [MagiQ Technologies, Inc., Somerville, MA (United States)

    2014-03-27

    An alternative synchronization technique – one that would allow explicit control of the pulse train including its repetition rate and delay is clearly desired. We propose such a scheme. Our method is based on optical interferometry and permits synchronization of the pulse trains generated by two independent mode-locked lasers. As the next generation x-ray sources will be driven by a clock signal derived from a mode-locked optical source, our technique will provide a way to synchronize x-ray probe with the optical pump pulses.

  20. Mobility Models for Next Generation Wireless Networks Ad Hoc, Vehicular and Mesh Networks

    CERN Document Server

    Santi, Paolo

    2012-01-01

    Mobility Models for Next Generation Wireless Networks: Ad Hoc, Vehicular and Mesh Networks provides the reader with an overview of mobility modelling, encompassing both theoretical and practical aspects related to the challenging mobility modelling task. It also: Provides up-to-date coverage of mobility models for next generation wireless networksOffers an in-depth discussion of the most representative mobility models for major next generation wireless network application scenarios, including WLAN/mesh networks, vehicular networks, wireless sensor networks, and

  1. Flood Finder: Mobile-based automated water level estimation and mapping during floods

    International Nuclear Information System (INIS)

    Pongsiriyaporn, B; Jariyavajee, C; Laoharawee, N; Narkthong, N; Pitichat, T; Goldin, S E

    2014-01-01

    Every year, Southeast Asia faces numerous flooding disasters, resulting in very high human and economic loss. Responding to a sudden flood is difficult due to the lack of accurate and up-to- date information about the incoming water status. We have developed a mobile application called Flood Finder to solve this problem. Flood Finder allows smartphone users to measure, share and search for water level information at specified locations. The application uses image processing to compute the water level from a photo taken by users. The photo must be of a known reference object with a standard size. These water levels are more reliable and consistent than human estimates since they are derived from an algorithmic measuring function. Flood Finder uploads water level readings to the server, where they can be searched and mapped by other users via the mobile phone app or standard browsers. Given the widespread availability of smartphones in Asia, Flood Finder can provide more accurate and up-to-date information for better preparation for a flood disaster as well as life safety and property protection

  2. Precision medicine for cancer with next-generation functional diagnostics.

    Science.gov (United States)

    Friedman, Adam A; Letai, Anthony; Fisher, David E; Flaherty, Keith T

    2015-12-01

    Precision medicine is about matching the right drugs to the right patients. Although this approach is technology agnostic, in cancer there is a tendency to make precision medicine synonymous with genomics. However, genome-based cancer therapeutic matching is limited by incomplete biological understanding of the relationship between phenotype and cancer genotype. This limitation can be addressed by functional testing of live patient tumour cells exposed to potential therapies. Recently, several 'next-generation' functional diagnostic technologies have been reported, including novel methods for tumour manipulation, molecularly precise assays of tumour responses and device-based in situ approaches; these address the limitations of the older generation of chemosensitivity tests. The promise of these new technologies suggests a future diagnostic strategy that integrates functional testing with next-generation sequencing and immunoprofiling to precisely match combination therapies to individual cancer patients.

  3. Next generation capacity building for the GEOSS community - an European approach

    Science.gov (United States)

    Bye, B. L.

    2016-12-01

    The Group on Earth observation embarked on the next 10 year phase with an ambition to streamline and futher develop its achievements in building the Global Earth Observing System of Systems (GEOSS). The NextGEOSS project evolves the European vision of GEOSS data exploitation for innovation and business, relying on the three main pillars of engaging communities, delivering technological developments and advocating the use of GEOSS, in order to support the creation and deployment of Earth observation based innovative research activities and commercial services. In this presentation we will present the new integrated approach to capacity building engaging the various actors involved in the entire value-chain from data providers to decision-makers. A presentation of the general approach together with concrete pilot cases will be included.In this work it will be shown how we integrate new technological development and societial change enabling GEO and GEOSS to adapt to the current environment. The result is important for better decision-making and better use of our limited resources to manage our planet.

  4. Next-generation storm tracking for minimizing service interruption

    Energy Technology Data Exchange (ETDEWEB)

    Sznaider, R. [Meteorlogix, Minneapolis, MN (United States)

    2002-08-01

    Several technological changes have taken place in the field of weather radar since its discovery during World War II. A wide variety of industries have benefited over the years from conventional weather radar displays, providing assistance in forecasting and estimating the potential severity of storms. The characteristics of individual storm cells can now be derived from the next-generation of weather radar systems (NEXRAD). The determination of which storm cells possess distinct features such as large hail or developing tornadoes was made possible through the fusing of various pieces of information with radar pictures. To exactly determine when and where a storm will hit, this data can be combined and overlaid into a display that includes the geographical physical landmarks of a specific region. Combining Geographic Information Systems (GIS) and storm tracking provides a more complete, timely and accurate forecast, which clearly benefits the electric utilities industries. The generation and production of energy are dependent on how hot or cold it will be today and tomorrow. The author described each major feature of this next-generation weather radar system. 9 figs.

  5. Educating the next generation of nature entrepreneurs

    Science.gov (United States)

    Judith C. Jobse; Loes Witteveen; Judith Santegoets; Daan van der Linde

    2015-01-01

    With this paper, it is illustrated that a focus on entrepreneurship training in the nature and wilderness sector is relevant for diverse organisations and situations. The first curricula on nature entrepreneurship are currently being developed. In this paper the authors describe a project that focusses on educating the next generation of nature entrepreneurs, reflect...

  6. The Next Generation: Students Discuss Archaeology in the 21st Century

    OpenAIRE

    Sands, Ashley; Butler, Kristin

    2010-01-01

    The Next Generation Project is a multi-agent, multi-directional cultural diplomacy effort. The need for communication among emerging archaeologists has never been greater. Increasingly, archaeological sites are impacted by military activity, destroyed through the development of dams and building projects, and torn apart through looting. The Next Generation Project works to develop communication via social networking sites online and through in-person meetings at international conferences. As ...

  7. NIRS report of investigations for the development of the next generation PET apparatus. FY 2000

    International Nuclear Information System (INIS)

    2001-03-01

    This is a summary of study reports from representative technology fields for the development of the next generation PET apparatus directing to 3-D images, and is hoped to be useful for future smooth cooperation between the fields. The investigation started from April 2000 in National Institute of Radiological Sciences (NIRS) with cooperation of other facilities, universities and companies. The report involves chapters of: Detector volume and geometrical efficiency- Design criterion for the next generation PET; Scintillator for PET; An investigation of detector and front-end electronics for the next generation PET; A measurement system of depth of interaction; Detector simulator; Development of an evaluation system for PET detector; On the signal processing system for the next generation PET; List-mode data acquisition method for the next generation PET; List-mode data acquisition simulator; Image reconstruction; A Monte Carlo simulator for the next generation PET scanners; Out-of-field of view (FOV) radioactivity; and Published papers and presentations. (N.I.)

  8. The next generation of power reactors - safety characteristics

    International Nuclear Information System (INIS)

    Modro, S.M.

    1995-01-01

    The next generation of commercial nuclear power reactors is characterized by a new approach to achieving reliability of their safety systems. In contrast to current generation reactors, these designs apply passive safety features that rely on gravity-driven transfer processes or stored energy, such as gas-pressurized accumulators or electric batteries. This paper discusses the passive safety system of the AP600 and Simplified Boiling Water Reactor (SBWR) designs

  9. Frontiers of Radio Astronomy in the 2020s: The Next Generation Very Large Array

    Science.gov (United States)

    Murphy, Eric Joseph; ngVLA Project Office, ngVLA Science and Technical Advisory Councils, ngVLA Science Working Groups

    2018-01-01

    This talk will describe the current community-driven science goals, design, and planning status of a future large centimeter radio array: the ‘Next Generation Very Large Array’ (ngVLA). The ngVLA is being developed to observe at wavelengths between ALMA at submm wavelengths, and the future SKA-1 at few centimeter and longer wavelengths, opening a new window on the Universe through ultra-sensitive imaging of thermal line and continuum emission down to milliarcsecond resolution, and unprecedented broad band continuum polarimetric imaging of non-thermal processes. The current design for the array includes 10x more effective collecting area and 10x higher spatial resolution than the current JVLA or ALMA, carefully optimized for operation in the frequency range 10GHz to 50GHz, while still delivering world-leading sensitivity over the entire 1.2GHz to 116 GHz spectrum.With this array, new frontiers in modern astronomy can be reached, including direct imaging and chemical analysis of planet formation in the terrestrial-zone of nearby stars, studies of dust-obscured star formation and the cosmic baryon cycle down to pc-scales in the local Universe, and detailed imaging of molecular gas and galaxy formation into the epoch of reionization. Novel techniques for exploring temporal phenomena on timescales from milliseconds to years will also be implemented. The ngVLA will be situated in the desert southwest of the United States, centered on the current JVLA infrastructure, with multiple antennas anticipated in states/regions adjacent to NM, and in northern Mexico.A recently formed Project Office is working closely with the U.S. and international research community to design the array, and plan its construction beginning mid next decade. Recent significant funding for design and development brought forward by the NSF will enable detailed science case development and technology prototyping/risk reduction before the next U.S astronomy Decadal Survey.

  10. Next generation solar energy. From fundamentals to applications

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    Within the International Conference between 12th and 14th December, 2011 in Erlangen (Federal Republic of Germany) the following lectures were presented: (1) The opto-electronic physics required to approach the Shockley-Queisser efficiency limit (E. Yablonovitch); (2) The Shockley-Queisser-limit and beyond (G.H. Bauer); (3) Designing composite nanomaterials for photovoltaic devices (B. Rech); (4) Light-Material interactions in energy conversion (H. Atwater); (5) Functional imaging of hybrid nanostructures - Visualizing mechanisms of solar energy utilization (L. Lauhon); (6) Are photosynthetic proteins suitable for PV applications (Y. Rosenwaks); (7) Detailed balance limit in photovoltaic systems (U. Rau); (8) Plasmonics and nanophotonics for next generation photovoltaics (E. Garnett); (9) Dispersion, wave propagation and efficiency analysis of nanowire solar cells (B. Witzigmann); (10) Application of nanostructures to next generation photovoltaics - Opportunities and challenges from an industrial research perspective (L. Tsakalakos); (11) Triplet states in organic and organometallic photovoltaic cells (K.S. Schanze); (12) New photoelectrode architectures (J.T. Hupp); (13) Dendrimers for optoelectronic and photovoltaic applications (P. Ceroni); (14) Photon management with luminescent materials (J. Goldschmidt); (15) Economical aspects of next generation solar cell technologies (W. Hoffmann); (16) Scalability in solar energy conversion - First-row transition metal-based chromophores for dye-sensitized solar cells (J. McCusker); (17) Designing organic materials for photovoltaic devices (A. Harriman); (18) Molecular photovoltaics - What can we learn from model studies (B. Albinsson); (19) Porphyrin-sensitised titanium dioxide solar cells (D. Officer); (20) Light-harvesting: Charge separation, and charge-transportation properties of novel materials for organic photovoltaics (H. Imahori); (21) Phthalocyanines for molecular photovoltaics (T. Torres); (22) Photophysics of

  11. Next Generation, Si-Compatible Materials and Devices in the Si-Ge-Sn System

    Science.gov (United States)

    2015-10-09

    and conclusions The work initially focused on growth of next generation Ge1-ySny alloys on Ge buffered Si wafers via UHV CVD depositions of Ge3H8...Abstract The work initially focused on growth of next generation Ge1-ySny alloys on Ge buffered Si wafers via UHV CVD depositions of Ge3H8, SnD4. The...AFRL-AFOSR-VA-TR-2016-0044 Next generation, Si -compatible materials and devices in the Si - Ge -Sn system John Kouvetakis ARIZONA STATE UNIVERSITY Final

  12. HLA typing: Conventional techniques v.next-generation sequencing

    African Journals Online (AJOL)

    The existing techniques have contributed significantly to our current knowledge of allelic diversity. At present, sequence-based typing (SBT) methods, in particular next-generation sequencing. (NGS), provide the highest possible resolution. NGS platforms were initially only used for genomic sequencing, but also showed.

  13. Next-generation sequencing for endocrine cancers: Recent advances and challenges.

    Science.gov (United States)

    Suresh, Padmanaban S; Venkatesh, Thejaswini; Tsutsumi, Rie; Shetty, Abhishek

    2017-05-01

    Contemporary molecular biology research tools have enriched numerous areas of biomedical research that address challenging diseases, including endocrine cancers (pituitary, thyroid, parathyroid, adrenal, testicular, ovarian, and neuroendocrine cancers). These tools have placed several intriguing clues before the scientific community. Endocrine cancers pose a major challenge in health care and research despite considerable attempts by researchers to understand their etiology. Microarray analyses have provided gene signatures from many cells, tissues, and organs that can differentiate healthy states from diseased ones, and even show patterns that correlate with stages of a disease. Microarray data can also elucidate the responses of endocrine tumors to therapeutic treatments. The rapid progress in next-generation sequencing methods has overcome many of the initial challenges of these technologies, and their advantages over microarray techniques have enabled them to emerge as valuable aids for clinical research applications (prognosis, identification of drug targets, etc.). A comprehensive review describing the recent advances in next-generation sequencing methods and their application in the evaluation of endocrine and endocrine-related cancers is lacking. The main purpose of this review is to illustrate the concepts that collectively constitute our current view of the possibilities offered by next-generation sequencing technological platforms, challenges to relevant applications, and perspectives on the future of clinical genetic testing of patients with endocrine tumors. We focus on recent discoveries in the use of next-generation sequencing methods for clinical diagnosis of endocrine tumors in patients and conclude with a discussion on persisting challenges and future objectives.

  14. The next generation CANDU 6

    International Nuclear Information System (INIS)

    Hopwood, J.M.

    1999-01-01

    AECL's product line of CANDU 6 and CANDU 9 nuclear power plants are adapted to respond to changing market conditions, experience feedback and technological development by a continuous improvement process of design evolution. The CANDU 6 Nuclear Power Plant design is a successful family of nuclear units, with the first four units entering service in 1983, and the most recent entering service this year. A further four CANDU 6 units are under construction. Starting in 1996, a focused forward-looking development program is under way at AECL to incorporate a series of individual improvements and integrate them into the CANDU 6, leading to the evolutionary development of the next-generation enhanced CANDU 6. The CANDU 6 improvements program includes all aspects of an NPP project, including engineering tools improvements, design for improved constructability, scheduling for faster, more streamlined commissioning, and improved operating performance. This enhanced CANDU 6 product will combine the benefits of design provenness (drawing on the more than 70 reactor-years experience of the seven operating CANDU 6 units), with the advantages of an evolutionary next-generation design. Features of the enhanced CANDU 6 design include: Advanced Human Machine Interface - built around the Advanced CANDU Control Centre; Advanced fuel design - using the newly demonstrated CANFLEX fuel bundle; Improved Efficiency based on improved utilization of waste heat; Streamlined System Design - including simplifications to improve performance and safety system reliability; Advanced Engineering Tools, -- featuring linked electronic databases from 3D CADDS, equipment specification and material management; Advanced Construction Techniques - based on open top equipment installation and the use of small skid mounted modules; Options defined for Passive Heat Sink capability and low-enrichment core optimization. (author)

  15. Bioinformatics for Next Generation Sequencing Data

    Directory of Open Access Journals (Sweden)

    Alberto Magi

    2010-09-01

    Full Text Available The emergence of next-generation sequencing (NGS platforms imposes increasing demands on statistical methods and bioinformatic tools for the analysis and the management of the huge amounts of data generated by these technologies. Even at the early stages of their commercial availability, a large number of softwares already exist for analyzing NGS data. These tools can be fit into many general categories including alignment of sequence reads to a reference, base-calling and/or polymorphism detection, de novo assembly from paired or unpaired reads, structural variant detection and genome browsing. This manuscript aims to guide readers in the choice of the available computational tools that can be used to face the several steps of the data analysis workflow.

  16. Next Generation HeliMag UXO Mapping Technology

    Science.gov (United States)

    2010-01-01

    Ancillary instrumentation records aircraft height above ground and attitude. A fluxgate magnetometer is used to allow for aeromagnetic compensation of... Magnetometer System WWII World War II WAA wide area assessment ACKNOWLEDGEMENTS This Next Generation HeliMag Unexploded Ordnance (UXO) Mapping...for deployment of seven total-field magnetometers on a Kevlar reinforced boom mounted on a Bell 206L helicopter. The objectives of this

  17. Application of Next Generation Sequencing on Genetic Testing

    DEFF Research Database (Denmark)

    Li, Jian

    The discovery of genetic factors behind increasing number of human diseases and the growth of education of genetic knowledge to the public make demands for genetic testing increase rapidly. However, traditional genetic testing methods cannot meet all kinds of the requirements. Next generation seq...

  18. HLA typing: Conventional techniques v. next-generation sequencing ...

    African Journals Online (AJOL)

    Background. The large number of population-specific polymorphisms present in the HLA complex in the South African (SA) population reduces the probability of finding an adequate HLA-matched donor for individuals in need of an unrelated haematopoietic stem cell transplantation (HSCT). Next-generation sequencing ...

  19. NGSS and the Next Generation of Science Teachers

    Science.gov (United States)

    Bybee, Rodger W.

    2014-01-01

    This article centers on the "Next Generation Science Standards" (NGSS) and their implications for teacher development, particularly at the undergraduate level. After an introduction to NGSS and the influence of standards in the educational system, the article addresses specific educational shifts--interconnecting science and engineering…

  20. Next-generation sequencing offers new insights into DNA degradation

    DEFF Research Database (Denmark)

    Overballe-Petersen, Søren; Orlando, Ludovic Antoine Alexandre; Willerslev, Eske

    2012-01-01

    The processes underlying DNA degradation are central to various disciplines, including cancer research, forensics and archaeology. The sequencing of ancient DNA molecules on next-generation sequencing platforms provides direct measurements of cytosine deamination, depurination and fragmentation...... rates that previously were obtained only from extrapolations of results from in vitro kinetic experiments performed over short timescales. For example, recent next-generation sequencing of ancient DNA reveals purine bases as one of the main targets of postmortem hydrolytic damage, through base...... elimination and strand breakage. It also shows substantially increased rates of DNA base-loss at guanosine. In this review, we argue that the latter results from an electron resonance structure unique to guanosine rather than adenosine having an extra resonance structure over guanosine as previously suggested....

  1. Hole-y Debris Disks, Batman! Where are the planets?

    Science.gov (United States)

    Bailey, V.; Meshkat, T.; Hinz, P.; Kenworthy, M.; Su, K. Y. L.

    2014-03-01

    Giant planets at wide separations are rare and direct imaging surveys are resource-intensive, so a cheaper marker for the presence of giant planets is desirable. One intriguing possibility is to use the effect of planets on their host stars' debris disks. Theoretical studies indicate giant planets can gravitationally carve sharp boundaries and gaps in their disks; this has been seen for HR 8799, β Pic, and tentatively for HD 95086 (Su et al. 2009, Lagrange et al. 2010, Moor et al. 2013). If more broadly demonstrated, this link could help guide target selection for next generation direct imaging surveys. Using Spitzer MIPS/IRS spectral energy distributions (SEDs), we identify several dozen systems with two-component and/or large inner cavity disks (aka Hole-y Debris Disks). With LBT/LBTI, VLT/NaCo, GeminiS/NICI, MMT/Clio and Magellan/Clio, we survey a subset these SEDselected targets (~20). In contrast to previous disk-selected planet surveys (e.g.: Janson et al. 2013, Wahhaj et al. 2013) we image primarily in the thermal IR (L'-band), where planet-to-star contrast is more favorable and background contaminants less numerous. Thus far, two of our survey targets host planet-mass companions, both of which were discovered in L'-band after they were unrecognized or undetectable in H-band. For each system in our sample set, we will investigate whether the known companions and/or companions below our detection threshold could be responsible for the disk architecture. Ultimately, we will increase our effective sample size by incorporating detection limits from surveys that have independently targeted some of our systems of interest. In this way we will refine the conditions under which disk SED-based target selection is likely to be useful and valid.

  2. SearchResultFinder: federated search made easy

    NARCIS (Netherlands)

    Trieschnigg, Rudolf Berend; Tjin-Kam-Jet, Kien; Hiemstra, Djoerd

    Building a federated search engine based on a large number existing web search engines is a challenge: implementing the programming interface (API) for each search engine is an exacting and time-consuming job. In this demonstration we present SearchResultFinder, a browser plugin which speeds up

  3. NOAA Next Generation Radar (NEXRAD) Level 2 Base Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset consists of Level II weather radar data collected from Next-Generation Radar (NEXRAD) stations located in the contiguous United States, Alaska, Hawaii,...

  4. 76 FR 77939 - Proposed Provision of Navigation Services for the Next Generation Air Transportation System...

    Science.gov (United States)

    2011-12-15

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Parts 91, 121, 125, 129, and 135 Proposed Provision of Navigation Services for the Next Generation Air Transportation System (Next...) navigation infrastructure to enable performance-based navigation (PBN) as part of the Next Generation Air...

  5. Cloud Sourcing – Next Generation Outsourcing?

    OpenAIRE

    Muhic, Mirella; Johansson, Björn

    2014-01-01

    Although Cloud Sourcing has been around for some time it could be questioned what actually is known about it. This paper presents a literature review on the specific question if Cloud Sourcing could be seen as the next generation of outsourcing. The reason for doing this is that from an initial sourcing study we found that the sourcing decisions seems to go in the direction of outsourcing as a service which could be described as Cloud Sourcing. Whereas some are convinced that Cloud Sourcing r...

  6. Securing Networks from Modern Threats using Next Generation Firewalls

    OpenAIRE

    Delgiusto, Valter

    2016-01-01

    Classic firewalls have long been unable to cope with modern threats that ordinary Internet users are exposed to. This thesis discusses their successors - the next-generation firewalls. The first part of the thesis describes modern threats and attacks. We described in detail the DoS and APT attacks, which are among the most frequent and which may cause most damage to the system under attack. Then we explained the theoretical basics of firewalls and described the functionalities of next gen...

  7. Next generation of energy production systems

    International Nuclear Information System (INIS)

    Rouault, J.; Garnier, J.C.; Carre, F.

    2003-01-01

    This document gathers the slides that have been presented at the Gedepeon conference. Gedepeon is a research group involving scientists from Cea (French atomic energy commission), CNRS (national center of scientific research), EDF (electricity of France) and Framatome that is devoted to the study of new energy sources and particularly to the study of the future generations of nuclear systems. The contributions have been classed into 9 topics: 1) gas cooled reactors, 2) molten salt reactors (MSBR), 3) the recycling of plutonium and americium, 4) reprocessing of molten salt reactor fuels, 5) behavior of graphite under radiation, 6) metallic materials for molten salt reactors, 7) refractory fuels of gas cooled reactors, 8) the nuclear cycle for the next generations of nuclear systems, and 9) organization of research programs on the new energy sources

  8. Novel nanostructures for next generation dye-sensitized solar cells

    KAUST Repository

    Té treault, Nicolas; Grä tzel, Michael

    2012-01-01

    Herein, we review our latest advancements in nanostructured photoanodes for next generation photovoltaics in general and dye-sensitized solar cells in particular. Bottom-up self-assembly techniques are developed to fabricate large-area 3D

  9. Next generation HOM-damping

    Science.gov (United States)

    Marhauser, Frank

    2017-06-01

    Research and development for superconducting radio-frequency cavities has made enormous progress over the last decades from the understanding of theoretical limitations to the industrial mass fabrication of cavities for large-scale particle accelerators. Key technologies remain hot topics due to continuously growing demands on cavity performance, particularly when in pursuit of high quality beams at higher beam currents or higher luminosities than currently achievable. This relates to higher order mode (HOM) damping requirements. Meeting the desired beam properties implies avoiding coupled multi-bunch or beam break-up instabilities depending on the machine and beam parameters that will set the acceptable cavity impedance thresholds. The use of cavity HOM-dampers is crucial to absorb the wakefields, comprised by all beam-induced cavity Eigenmodes, to beam-dynamically safe levels and to reduce the heat load at cryogenic temperature. Cavity damping concepts may vary, but are principally based on coaxial and waveguide couplers as well as beam line absorbers or any combination. Next generation energy recovery linacs and circular colliders call for cavities with strong HOM-damping that can exceed the state-of-the-art, while the operating mode efficiency shall not be significantly compromised concurrently. This imposes major challenges given the rather limited damping concepts. A detailed survey of established cavities is provided scrutinizing the achieved damping performance, shortcomings, and potential improvements. The scaling of the highest passband mode impedances is numerically evaluated in dependence on the number of cells for a single-cell up to a nine-cell cavity, which reveals the increased probability of trapped modes. This is followed by simulations for single-cell and five-cell cavities, which incorporate multiple damping schemes to assess the most efficient concepts. The usage and viability of on-cell dampers is elucidated for the single-cell cavity since it

  10. Preparing the Next Generation of Educators for Democracy

    Science.gov (United States)

    Embry-Jenlink, Karen

    2018-01-01

    In the keynote address of the 42nd annual meeting of the Southeastern Regional Educators Association (SRATE), ATE President Karen Embry-Jenlink examines the critical role of teacher educators in preparing the next generation of citizens and leaders to sustain democracy. Drawing from historic and current events and personal experience,…

  11. Next Generation Science Standards: All Standards, All Students

    Science.gov (United States)

    Lee, Okhee; Miller, Emily C.; Januszyk, Rita

    2014-01-01

    The Next Generation Science Standards (NGSS) offer a vision of science teaching and learning that presents both learning opportunities and demands for all students, particularly student groups that have traditionally been underserved in science classrooms. The NGSS have addressed issues of diversity and equity from their inception, and the NGSS…

  12. Next generation advanced nuclear reactor designs

    International Nuclear Information System (INIS)

    Turgut, M. H.

    2009-01-01

    Growing energy demand by technological developments and the increase of the world population and gradually diminishing energy resources made nuclear power an indispensable option. The renewable energy sources like solar, wind and geothermal may be suited to meet some local needs. Environment friendly nuclear energy which is a suitable solution to large scale demands tends to develop highly economical, advanced next generation reactors by incorporating technological developments and years of operating experience. The enhancement of safety and reliability, facilitation of maintainability, impeccable compatibility with the environment are the goals of the new generation reactors. The protection of the investment and property is considered as well as the protection of the environment and mankind. They became economically attractive compared to fossil-fired units by the use of standard designs, replacing some active systems by passive, reducing construction time and increasing the operation lifetime. The evolutionary designs were introduced at first by ameliorating the conventional plants, than revolutionary systems which are denoted as generation IV were verged to meet future needs. The investigations on the advanced, proliferation resistant fuel cycle technologies were initiated to minimize the radioactive waste burden by using new generation fast reactors and ADS transmuters.

  13. Next-Generation Sequencing in the Mycology Lab.

    Science.gov (United States)

    Zoll, Jan; Snelders, Eveline; Verweij, Paul E; Melchers, Willem J G

    New state-of-the-art techniques in sequencing offer valuable tools in both detection of mycobiota and in understanding of the molecular mechanisms of resistance against antifungal compounds and virulence. Introduction of new sequencing platform with enhanced capacity and a reduction in costs for sequence analysis provides a potential powerful tool in mycological diagnosis and research. In this review, we summarize the applications of next-generation sequencing techniques in mycology.

  14. Fiber to the home: next generation network

    Science.gov (United States)

    Yang, Chengxin; Guo, Baoping

    2006-07-01

    Next generation networks capable of carrying converged telephone, television (TV), very high-speed internet, and very high-speed bi-directional data services (like video-on-demand (VOD), Game etc.) strategy for Fiber To The Home (FTTH) is presented. The potential market is analyzed. The barriers and some proper strategy are also discussed. Several technical problems like various powering methods, optical fiber cables, and different network architecture are discussed too.

  15. Next generation multi-particle event generators for the MSSM

    International Nuclear Information System (INIS)

    Reuter, J.; Kilian, W.; Hagiwara, K.; Krauss, F.; Schumann, S.; Rainwater, D.

    2005-12-01

    We present a next generation of multi-particle Monte Carlo (MC) Event generators for LHC and ILC for the MSSM, namely the three program packages Madgraph/MadEvent, WHiZard/O'Mega and Sherpa/Amegic++. The interesting but difficult phenomenology of supersymmetric models at the upcoming colliders demands a corresponding complexity and maturity from simulation tools. This includes multi-particle final states, reducible and irreducible backgrounds, spin correlations, real emission of photons and gluons, etc., which are incorporated in the programs presented here. The framework of a model with such a huge particle content and as complicated as the MSSM makes strenuous tests and comparison of codes inevitable. Various tests show agreement among the three different programs; the tables of cross sections produced in these tests may serve as a future reference for other codes. Furthermore, first MSSM physics analyses performed with these programs are presented here. (orig.)

  16. Next-Generation Thermal Infrared Multi-Body Radiometer Experiment (TIMBRE)

    Science.gov (United States)

    Kenyon, M.; Mariani, G.; Johnson, B.; Brageot, E.; Hayne, P.

    2016-10-01

    We have developed an instrument concept called TIMBRE which belongs to the important class of instruments called thermal imaging radiometers (TIRs). TIMBRE is the next-generation TIR with unparalleled performance compared to the state-of-the-art.

  17. Next generation ATCA control infrastructure for the CMS Phase-2 upgrades

    CERN Document Server

    Smith, Wesley; Svetek, Aleš; Tikalsky, Jes; Fobes, Robert; Dasu, Sridhara; Smith, Wesley; Vicente, Marcelo

    2017-01-01

    A next generation control infrastructure to be used in Advanced TCA (ATCA) blades at CMS experiment is being designed and tested. Several ATCA systems are being prepared for the High-Luminosity LHC (HL-LHC) and will be installed at CMS during technical stops. The next generation control infrastructure will provide all the necessary hardware, firmware and software required in these systems, decreasing development time and increasing flexibility. The complete infrastructure includes an Intelligent Platform Management Controller (IPMC), a Module Management Controller (MMC) and an Embedded Linux Mezzanine (ELM) processing card.

  18. What can next generation sequencing do for you? Next generation sequencing as a valuable tool in plant research

    OpenAIRE

    Bräutigam, Andrea; Gowik, Udo

    2010-01-01

    Next generation sequencing (NGS) technologies have opened fascinating opportunities for the analysis of plants with and without a sequenced genome on a genomic scale. During the last few years, NGS methods have become widely available and cost effective. They can be applied to a wide variety of biological questions, from the sequencing of complete eukaryotic genomes and transcriptomes, to the genome-scale analysis of DNA-protein interactions. In this review, we focus on the use of NGS for pla...

  19. Targeted enrichment strategies for next-generation plant biology

    Science.gov (United States)

    Richard Cronn; Brian J. Knaus; Aaron Liston; Peter J. Maughan; Matthew Parks; John V. Syring; Joshua. Udall

    2012-01-01

    The dramatic advances offered by modem DNA sequencers continue to redefine the limits of what can be accomplished in comparative plant biology. Even with recent achievements, however, plant genomes present obstacles that can make it difficult to execute large-scale population and phylogenetic studies on next-generation sequencing platforms. Factors like large genome...

  20. Next Generation Science Standards: Adoption and Implementation Workbook

    Science.gov (United States)

    Peltzman, Alissa; Rodriguez, Nick

    2013-01-01

    The Next Generation Science Standards (NGSS) represent the culmination of years of collaboration and effort by states, science educators and experts from across the United States. Based on the National Research Council's "A Framework for K-12 Science Education" and developed in partnership with 26 lead states, the NGSS, when…

  1. Framework for Leading Next Generation Science Standards Implementation

    Science.gov (United States)

    Stiles, Katherine; Mundry, Susan; DiRanna, Kathy

    2017-01-01

    In response to the need to develop leaders to guide the implementation of the Next Generation Science Standards (NGSS), the Carnegie Corporation of New York provided funding to WestEd to develop a framework that defines the leadership knowledge and actions needed to effectively implement the NGSS. The development of the framework entailed…

  2. Mobility management techniques for the next-generation wireless networks

    Science.gov (United States)

    Sun, Junzhao; Howie, Douglas P.; Sauvola, Jaakko J.

    2001-10-01

    The tremendous demands from social market are pushing the booming development of mobile communications faster than ever before, leading to plenty of new advanced techniques emerging. With the converging of mobile and wireless communications with Internet services, the boundary between mobile personal telecommunications and wireless computer networks is disappearing. Wireless networks of the next generation need the support of all the advances on new architectures, standards, and protocols. Mobility management is an important issue in the area of mobile communications, which can be best solved at the network layer. One of the key features of the next generation wireless networks is all-IP infrastructure. This paper discusses the mobility management schemes for the next generation mobile networks through extending IP's functions with mobility support. A global hierarchical framework model for the mobility management of wireless networks is presented, in which the mobility management is divided into two complementary tasks: macro mobility and micro mobility. As the macro mobility solution, a basic principle of Mobile IP is introduced, together with the optimal schemes and the advances in IPv6. The disadvantages of the Mobile IP on solving the micro mobility problem are analyzed, on the basis of which three main proposals are discussed as the micro mobility solutions for mobile communications, including Hierarchical Mobile IP (HMIP), Cellular IP, and Handoff-Aware Wireless Access Internet Infrastructure (HAWAII). A unified model is also described in which the different micro mobility solutions can coexist simultaneously in mobile networks.

  3. DECIPHERING THERMAL PHASE CURVES OF DRY, TIDALLY LOCKED TERRESTRIAL PLANETS

    Energy Technology Data Exchange (ETDEWEB)

    Koll, Daniel D. B.; Abbot, Dorian S., E-mail: dkoll@uchicago.edu [Department of the Geophysical Sciences, University of Chicago, Chicago, IL 60637 (United States)

    2015-03-20

    Next-generation space telescopes will allow us to characterize terrestrial exoplanets. To do so effectively it will be crucial to make use of all available data. We investigate which atmospheric properties can, and cannot, be inferred from the broadband thermal phase curve of a dry and tidally locked terrestrial planet. First, we use dimensional analysis to show that phase curves are controlled by six nondimensional parameters. Second, we use an idealized general circulation model to explore the relative sensitivity of phase curves to these parameters. We find that the feature of phase curves most sensitive to atmospheric parameters is the peak-to-trough amplitude. Moreover, except for hot and rapidly rotating planets, the phase amplitude is primarily sensitive to only two nondimensional parameters: (1) the ratio of dynamical to radiative timescales and (2) the longwave optical depth at the surface. As an application of this technique, we show how phase curve measurements can be combined with transit or emission spectroscopy to yield a new constraint for the surface pressure and atmospheric mass of terrestrial planets. We estimate that a single broadband phase curve, measured over half an orbit with the James Webb Space Telescope, could meaningfully constrain the atmospheric mass of a nearby super-Earth. Such constraints will be important for studying the atmospheric evolution of terrestrial exoplanets as well as characterizing the surface conditions on potentially habitable planets.

  4. Designing Next Generation Massively Multithreaded Architectures for Irregular Applications

    Energy Technology Data Exchange (ETDEWEB)

    Tumeo, Antonino; Secchi, Simone; Villa, Oreste

    2012-08-31

    Irregular applications, such as data mining or graph-based computations, show unpredictable memory/network access patterns and control structures. Massively multi-threaded architectures with large node count, like the Cray XMT, have been shown to address their requirements better than commodity clusters. In this paper we present the approaches that we are currently pursuing to design future generations of these architectures. First, we introduce the Cray XMT and compare it to other multithreaded architectures. We then propose an evolution of the architecture, integrating multiple cores per node and next generation network interconnect. We advocate the use of hardware support for remote memory reference aggregation to optimize network utilization. For this evaluation we developed a highly parallel, custom simulation infrastructure for multi-threaded systems. Our simulator executes unmodified XMT binaries with very large datasets, capturing effects due to contention and hot-spotting, while predicting execution times with greater than 90% accuracy. We also discuss the FPGA prototyping approach that we are employing to study efficient support for irregular applications in next generation manycore processors.

  5. Next Generation Summer School

    Science.gov (United States)

    Eugenia, Marcu

    2013-04-01

    On 21.06.2010 the "Next Generation" Summer School has opened the doors for its first students. They were introduced in the astronomy world by astronomical observations, astronomy and radio-astronomy lectures, laboratory projects meant to initiate them into modern radio astronomy and radio communications. The didactic programme was structure as fallowing: 1) Astronomical elements from the visible spectrum (lectures + practical projects) 2) Radio astronomy elements (lectures + practical projects) 3) Radio communication base (didactic- recreative games) The students and professors accommodation was at the Agroturistic Pension "Popasul Iancului" situated at 800m from the Marisel Observatory. First day (summer solstice day) began with a practical activity: determination of the meridian by measurements of the shadow (the direction of one vertical alignment, when it has the smallest length). The experiment is very instructive and interesting because combines notions of physics, spatial geometry and basic astronomy elements. Next day the activities took place in four stages: the students processed the experimental data obtained on first day (on sheets of millimetre paper they represented the length of the shadow alignments according the time), each team realised its own sun quadrant, point were given considering the design and functionality of these quadrant, the four teams had to mimic important constellations on carton boards with phosphorescent sticky stars and the students, accompanied by the professors took a hiking trip to the surroundings, marking the interest point coordinates, using a GPS to establish the geographical coronations and at the end of the day the students realised a small map of central Marisel area based on the GPS data. On the third day, the students were introduced to basic notions of radio astronomy, the principal categories of artificial Earth satellites: low orbit satellites (LEO), Medium orbit satellites (MEO) and geostationary satellites (GEO

  6. The effect of lunarlike satellites on the orbital infrared light curves of Earth-analog planets.

    Science.gov (United States)

    Moskovitz, Nicholas A; Gaidos, Eric; Williams, Darren M

    2009-04-01

    We have investigated the influence of lunarlike satellites on the infrared orbital light curves of Earth-analog extrasolar planets. Such light curves will be obtained by NASA's Terrestrial Planet Finder (TPF) and ESA's Darwin missions as a consequence of repeat observations to confirm the companion status of a putative planet and determine its orbit. We used an energy balance model to calculate disk-averaged infrared (bolometric) fluxes from planet-satellite systems over a full orbital period (one year). The satellites are assumed to lack an atmosphere, have a low thermal inertia like that of the Moon, and span a range of plausible radii. The planets are assumed to have thermal and orbital properties that mimic those of Earth, while their obliquities and orbital longitudes of inferior conjunction remain free parameters. Even if the gross thermal properties of the planet can be independently constrained (e.g., via spectroscopy or visible-wavelength detection of specular glint from a surface ocean), only the largest (approximately Mars-sized) lunarlike satellites can be detected by light curve data from a TPF-like instrument (i.e., one that achieves a photometric signal-to-noise ratio of 10 to 20 at infrared wavelengths). Nondetection of a lunarlike satellite can obfuscate the interpretation of a given system's infrared light curve so that it may resemble a single planet with high obliquity, different orbital longitude of vernal equinox relative to inferior conjunction, and in some cases drastically different thermal characteristics. If the thermal properties of the planet are not independently established, then the presence of a lunarlike satellite cannot be inferred from infrared data, which would thus demonstrate that photometric light curves alone can only be used for preliminary study, and the addition of spectroscopic data will be necessary.

  7. Next-generation batteries and fuel cells for commercial, military, and space applications

    CERN Document Server

    Jha, A R

    2012-01-01

    Distilling complex theoretical physical concepts into an understandable technical framework, Next-Generation Batteries and Fuel Cells for Commercial, Military, and Space Applications describes primary and secondary (rechargeable) batteries for various commercial, military, spacecraft, and satellite applications for covert communications, surveillance, and reconnaissance missions. It emphasizes the cost, reliability, longevity, and safety of the next generation of high-capacity batteries for applications where high energy density, minimum weight and size, and reliability in harsh conditions are

  8. Convergence of wireless, wireline, and photonics next generation networks

    CERN Document Server

    Iniewski, Krzysztof

    2010-01-01

    Filled with illustrations and practical examples from industry, this book provides a brief but comprehensive introduction to the next-generation wireless networks that will soon replace more traditional wired technologies. Written by a mixture of top industrial experts and key academic professors, it is the only book available that covers both wireless networks (such as wireless local area and personal area networks) and optical networks (such as long-haul and metropolitan networks) in one volume. It gives engineers and engineering students the necessary knowledge to meet challenges of next-ge

  9. Efficient Cryptography for the Next Generation Secure Cloud

    Science.gov (United States)

    Kupcu, Alptekin

    2010-01-01

    Peer-to-peer (P2P) systems, and client-server type storage and computation outsourcing constitute some of the major applications that the next generation cloud schemes will address. Since these applications are just emerging, it is the perfect time to design them with security and privacy in mind. Furthermore, considering the high-churn…

  10. Statistical Approaches for Next-Generation Sequencing Data

    OpenAIRE

    Qiao, Dandi

    2012-01-01

    During the last two decades, genotyping technology has advanced rapidly, which enabled the tremendous success of genome-wide association studies (GWAS) in the search of disease susceptibility loci (DSLs). However, only a small fraction of the overall predicted heritability can be explained by the DSLs discovered. One possible explanation for this ”missing heritability” phenomenon is that many causal variants are rare. The recent development of high-throughput next-generation sequencing (NGS) ...

  11. Architectural and Algorithmic Requirements for a Next-Generation System Analysis Code

    Energy Technology Data Exchange (ETDEWEB)

    V.A. Mousseau

    2010-05-01

    This document presents high-level architectural and system requirements for a next-generation system analysis code (NGSAC) to support reactor safety decision-making by plant operators and others, especially in the context of light water reactor plant life extension. The capabilities of NGSAC will be different from those of current-generation codes, not only because computers have evolved significantly in the generations since the current paradigm was first implemented, but because the decision-making processes that need the support of next-generation codes are very different from the decision-making processes that drove the licensing and design of the current fleet of commercial nuclear power reactors. The implications of these newer decision-making processes for NGSAC requirements are discussed, and resulting top-level goals for the NGSAC are formulated. From these goals, the general architectural and system requirements for the NGSAC are derived.

  12. Designing Next Generation Telecom Regulation

    DEFF Research Database (Denmark)

    Henten, Anders; Samarajiva, Rohan

    – ICT convergence regulation and multisector utility regulation. Whatever structure of next generation telecom regulation is adopted, all countries will need to pay much greater attention to the need for increased coordination of policy directions and regulatory activities both across the industries......Continuously expanding applications of information and communication technologies (ICT) are transforming local, national, regional and international economies into network economies, the foundation for information societies. They are being built upon expanded and upgraded national telecom networks...... to creating an environment to foster a massive expansion in the coverage and capabilities of the information infrastructure networks, with national telecom regulators as the key implementers of the policies of reform. The first phase of reform has focused on industry specific telecom policy and regulation...

  13. ERP II: Next-generation Extended Enterprise Resource Planning

    DEFF Research Database (Denmark)

    Møller, Charles

    2004-01-01

    ERP II (ERP/2) systems is a new concept introduced by Gartner Group in 2000 in order to label the latest extensions of the ERP-systems. The purpose of this paper is to explore the next-generation of ERP systems, the Extended Enterprise Resource Planning (EERP or as we prefer to use: e...... impact on extended enterprise architecture.....

  14. ERP II - Next-generation Extended Enterprise Resource Planning

    DEFF Research Database (Denmark)

    Møller, Charles

    2003-01-01

    ERP II (ERP/2) systems is a new concept introduced by Gartner Group in 2000 in order to label the latest extensions of the ERP-systems. The purpose of this paper is to explore the next-generation of ERP systems, the Extended Enterprise Resource Planning (EERP or as we prefer to use: e...... impact on extended enterprise architecture....

  15. Next Generation Geothermal Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Brugman, John; Hattar, Mai; Nichols, Kenneth; Esaki, Yuri

    1995-09-01

    A number of current and prospective power plant concepts were investigated to evaluate their potential to serve as the basis of the next generation geothermal power plant (NGGPP). The NGGPP has been envisaged as a power plant that would be more cost competitive (than current geothermal power plants) with fossil fuel power plants, would efficiently use resources and mitigate the risk of reservoir under-performance, and minimize or eliminate emission of pollutants and consumption of surface and ground water. Power plant concepts were analyzed using resource characteristics at ten different geothermal sites located in the western United States. Concepts were developed into viable power plant processes, capital costs were estimated and levelized busbar costs determined. Thus, the study results should be considered as useful indicators of the commercial viability of the various power plants concepts that were investigated. Broadly, the different power plant concepts that were analyzed in this study fall into the following categories: commercial binary and flash plants, advanced binary plants, advanced flash plants, flash/binary hybrid plants, and fossil/geothed hybrid plants. Commercial binary plants were evaluated using commercial isobutane as a working fluid; both air-cooling and water-cooling were considered. Advanced binary concepts included cycles using synchronous turbine-generators, cycles with metastable expansion, and cycles utilizing mixtures as working fluids. Dual flash steam plants were used as the model for the commercial flash cycle. The following advanced flash concepts were examined: dual flash with rotary separator turbine, dual flash with steam reheater, dual flash with hot water turbine, and subatmospheric flash. Both dual flash and binary cycles were combined with other cycles to develop a number of hybrid cycles: dual flash binary bottoming cycle, dual flash backpressure turbine binary cycle, dual flash gas turbine cycle, and binary gas turbine

  16. A New Data Concentrator for the CMS Muon Barrel Track Finder

    CERN Document Server

    Triossi, Andrea

    2014-01-01

    The CMS muon trigger will undergo considerable enhancements in preparation for the LHC \\mbox{run-2}. In order to improve rate reduction and efficiency the full muon trigger chain will be completely redesigned: the plan is to move from a redundant scheme, where the three subdetectors (CSC, DT, RPC) have a separate track finder, to three geographical track finders (barrel, endcap and overlap) that combine trigger primitives of each sub-detector. In particular, the muon barrel track finder (MBTF) will host a new algorithm, that aggregating DT and RPC trigger data, will be able to improve the fake rejection and the muon momentum measurement.This report will focus on the adaptive layer of the MBTF called TwinMux. Its primary role will be to merge, arrange and fan-out the slow optical links from the chambers in faster links (10 Gbps). It will realize a full connectivity matrix between the on-detector electronics and the MBTF allowing for different processing schemes. The TwinMux will be implemented in $\\mu$TCA for...

  17. Environmental Information for the U.S. Next Generation Air Transportation System (NextGen)

    Science.gov (United States)

    Murray, J.; Miner, C.; Pace, D.; Minnis, P.; Mecikalski, J.; Feltz, W.; Johnson, D.; Iskendarian, H.; Haynes, J.

    2009-09-01

    It is estimated that weather is responsible for approximately 70% of all air traffic delays and cancellations in the United States. Annually, this produces an overall economic loss of nearly 40B. The FAA and NASA have determined that weather impacts and other environmental constraints on the U.S. National Airspace System (NAS) will increase to the point of system unsustainability unless the NAS is radically transformed. A Next Generation Air Transportation System (NextGen) is planned to accommodate the anticipated demand for increased system capacity and the super-density operations that this transformation will entail. The heart of the environmental information component that is being developed for NextGen will be a 4-dimensional data cube which will include a single authoritative source comprising probabilistic weather information for NextGen Air Traffic Management (ATM) systems. Aviation weather constraints and safety hazards typically comprise meso-scale, storm-scale and microscale observables that can significantly impact both terminal and enroute aviation operations. With these operational impacts in mind, functional and performance requirements for the NextGen weather system were established which require significant improvements in observation and forecasting capabilities. This will include satellite observations from geostationary and/or polar-orbiting hyperspectral sounders, multi-spectral imagers, lightning mappers, space weather monitors and other environmental observing systems. It will also require improved in situ and remotely sensed observations from ground-based and airborne systems. These observations will be used to better understand and to develop forecasting applications for convective weather, in-flight icing, turbulence, ceilings and visibility, volcanic ash, space weather and the environmental impacts of aviation. Cutting-edge collaborative research efforts and results from NASA, NOAA and the FAA which address these phenomena are summarized

  18. The contribution of next generation sequencing to epilepsy genetics

    DEFF Research Database (Denmark)

    Møller, Rikke S.; Dahl, Hans A.; Helbig, Ingo

    2015-01-01

    During the last decade, next generation sequencing technologies such as targeted gene panels, whole exome sequencing and whole genome sequencing have led to an explosion of gene identifications in monogenic epilepsies including both familial epilepsies and severe epilepsies, often referred to as ...

  19. Converged Wireless Networking and Optimization for Next Generation Services

    Directory of Open Access Journals (Sweden)

    J. Rodriguez

    2010-01-01

    Full Text Available The Next Generation Network (NGN vision is tending towards the convergence of internet and mobile services providing the impetus for new market opportunities in combining the appealing services of internet with the roaming capability of mobile networks. However, this convergence does not go far enough, and with the emergence of new coexistence scenarios, there is a clear need to evolve the current architecture to provide cost-effective end-to-end communication. The LOOP project, a EUREKA-CELTIC driven initiative, is one piece in the jigsaw by helping European industry to sustain a leading role in telecommunications and manufacturing of high-value products and machinery by delivering pioneering converged wireless networking solutions that can be successfully demonstrated. This paper provides an overview of the LOOP project and the key achievements that have been tunneled into first prototypes for showcasing next generation services for operators and process manufacturers.

  20. Cost and schedule reduction for next-generation Candu

    International Nuclear Information System (INIS)

    Hopwood, J.M.; Yu, S.; Pakan, M.; Soulard, M.

    2002-01-01

    AECL has developed a suite of technologies for Candu R reactors that enable the next step in the evolution of the Candu family of heavy-water-moderated fuel-channel reactors. These technologies have been combined in the design for the Advanced Candu Reactor TM1 (ACRTM), AECL's next generation Candu power plant. The ACR design builds extensively on the existing Candu experience base, but includes innovations, in design and in delivery technology, that provide very substantial reductions in capital cost and in project schedules. In this paper, main features of next generation design and delivery are summarized, to provide the background basis for the cost and schedule reductions that have been achieved. In particular the paper outlines the impact of the innovative design steps for ACR: - Selection of slightly enriched fuel bundle design; - Use of light water coolant in place of traditional Candu heavy water coolant; - Compact core design with unique reactor physics benefits; - Optimized coolant and turbine system conditions. In addition to the direct cost benefits arising from efficiency improvement, and from the reduction in heavy water, the next generation Candu configuration results in numerous additional indirect cost benefits, including: - Reduction in number and complexity of reactivity mechanisms; - Reduction in number of heavy water auxiliary systems; - Simplification in heat transport and its support systems; - Simplified human-machine interface. The paper also describes the ACR approach to design for constructability. The application of module assembly and open-top construction techniques, based on Candu and other worldwide experience, has been proven to generate savings in both schedule durations and overall project cost, by reducing premium on-site activities, and by improving efficiency of system and subsystem assembly. AECL's up-to-date experience in the use of 3-D CADDS and related engineering tools has also been proven to reduce both engineering and

  1. A new general purpose event horizon finder for 3D numerical spacetimes

    International Nuclear Information System (INIS)

    Diener, Peter

    2003-01-01

    I present a new general purpose event horizon finder for full 3D numerical spacetimes. It works by evolving a complete null surface backwards in time. The null surface is described as the zero-level set of a scalar function, which in principle is defined everywhere. This description of the surface allows the surface, trivially, to change topology, making this event horizon finder able to handle numerical spacetimes where two (or more) black holes merge into a single final black hole

  2. Next-Generation Sequencing of Antibody Display Repertoires

    Directory of Open Access Journals (Sweden)

    Romain Rouet

    2018-02-01

    Full Text Available In vitro selection technology has transformed the development of therapeutic monoclonal antibodies. Using methods such as phage, ribosome, and yeast display, high affinity binders can be selected from diverse repertoires. Here, we review strategies for the next-generation sequencing (NGS of phage- and other antibody-display libraries, as well as NGS platforms and analysis tools. Moreover, we discuss recent examples relating to the use of NGS to assess library diversity, clonal enrichment, and affinity maturation.

  3. Next-generation digital information storage in DNA.

    Science.gov (United States)

    Church, George M; Gao, Yuan; Kosuri, Sriram

    2012-09-28

    Digital information is accumulating at an astounding rate, straining our ability to store and archive it. DNA is among the most dense and stable information media known. The development of new technologies in both DNA synthesis and sequencing make DNA an increasingly feasible digital storage medium. We developed a strategy to encode arbitrary digital information in DNA, wrote a 5.27-megabit book using DNA microchips, and read the book by using next-generation DNA sequencing.

  4. Validation of the Applied Biosystems RapidFinder Shiga Toxin-Producing E. coli (STEC) Detection Workflow.

    Science.gov (United States)

    Cloke, Jonathan; Matheny, Sharon; Swimley, Michelle; Tebbs, Robert; Burrell, Angelia; Flannery, Jonathan; Bastin, Benjamin; Bird, Patrick; Benzinger, M Joseph; Crowley, Erin; Agin, James; Goins, David; Salfinger, Yvonne; Brodsky, Michael; Fernandez, Maria Cristina

    2016-11-01

    The Applied Biosystems™ RapidFinder™ STEC Detection Workflow (Thermo Fisher Scientific) is a complete protocol for the rapid qualitative detection of Escherichia coli (E. coli) O157:H7 and the "Big 6" non-O157 Shiga-like toxin-producing E. coli (STEC) serotypes (defined as serogroups: O26, O45, O103, O111, O121, and O145). The RapidFinder STEC Detection Workflow makes use of either the automated preparation of PCR-ready DNA using the Applied Biosystems PrepSEQ™ Nucleic Acid Extraction Kit in conjunction with the Applied Biosystems MagMAX™ Express 96-well magnetic particle processor or the Applied Biosystems PrepSEQ Rapid Spin kit for manual preparation of PCR-ready DNA. Two separate assays comprise the RapidFinder STEC Detection Workflow, the Applied Biosystems RapidFinder STEC Screening Assay and the Applied Biosystems RapidFinder STEC Confirmation Assay. The RapidFinder STEC Screening Assay includes primers and probes to detect the presence of stx1 (Shiga toxin 1), stx2 (Shiga toxin 2), eae (intimin), and E. coli O157 gene targets. The RapidFinder STEC Confirmation Assay includes primers and probes for the "Big 6" non-O157 STEC and E. coli O157:H7. The use of these two assays in tandem allows a user to detect accurately the presence of the "Big 6" STECs and E. coli O157:H7. The performance of the RapidFinder STEC Detection Workflow was evaluated in a method comparison study, in inclusivity and exclusivity studies, and in a robustness evaluation. The assays were compared to the U.S. Department of Agriculture (USDA), Food Safety and Inspection Service (FSIS) Microbiology Laboratory Guidebook (MLG) 5.09: Detection, Isolation and Identification of Escherichia coli O157:H7 from Meat Products and Carcass and Environmental Sponges for raw ground beef (73% lean) and USDA/FSIS-MLG 5B.05: Detection, Isolation and Identification of Escherichia coli non-O157:H7 from Meat Products and Carcass and Environmental Sponges for raw beef trim. No statistically significant

  5. Popular Imagination and Identity Politics: Reading the Future in "Star Trek: The Next Generation."

    Science.gov (United States)

    Ott, Brian L.; Aoki, Eric

    2001-01-01

    Analyzes the television series "Star Trek: The Next Generation." Theorizes the relationship between collective visions of the future and the identity politics of the present. Argues that "The Next Generation" invites audiences to participate in a shared sense of the future that constrains human agency and (re)produces the…

  6. Report on the FINDER Experiment at the HIgS Facility

    International Nuclear Information System (INIS)

    Hagmann, C.A.; Johnson, M.S; McNabb, D.P.; Tonchev, A.P.; Angell, C.; Hammond, S.; Howell, C.; Hutcheson, A.; Karwowski, H.; Kelley, J.; Kwan, E.; Rusev, G.; Tornow, W.

    2008-01-01

    Homeland Security programs are developing systems that use nuclear resonance fluorescence (NRF) to isotopically map a container. One such system being developed at LLNL is FINDER (Fluorescence Imaging in the Nuclear Domain with Extreme Radiation). The proposed FINDER system works by impinging a tunable monoenergetic gamma ray beam onto a container under investigation. The photons pass through the container and a fraction of them scatter off of the interior components through various electromagnetic processes. One of these processes is NRF. At specific resonance energies, incident photons interact directly with the nuclei of special nuclear material (SNM) or other materials in the container. The incident beam is absorbed and scattered into all directions, depleting the spectrum at the resonant energy. The transmitted gamma ray beam accrues a notch a few eV in width after passing through the material of interest. This notched spectrum will impinge on a witness foil placed on the opposite side of the container relative to the gamma ray source. The witness foil will be made of material identical to the one being sought after. If there is a notch in the spectrum then there will be no NRF photons scattered from the witness foil. The corollary is that if there is no notch in the transmitted spectrum then there will be NRF photons scattered from the witness foil. A simple arrangement of gamma-ray detectors focused on the witness foil, are used to measure the NRF photons. If the detectors see NRF scatter then there was no NRF scatter within the container; therefore, no material of the nature being sought after was in that container. Conversely, if there was no NRF scatter from the witness foil, then the NRF scatter took place from within the container; therefore, the material of interest is inside of the container. Recently, initial feasibility tests of FINDER was performed at the HIgS (High-Intensity Gamma Source) located at Duke University (1]. The preliminary results of

  7. Next Generation Life Support (NGLS): Rapid Cycle Amine Swing Bed

    Data.gov (United States)

    National Aeronautics and Space Administration — The Rapid Cycle Amine (RCA) swingbed has been identified as a technology with high potential to meet the stringent requirements for the next generation spacesuit's...

  8. Modelling of control system architecture for next-generation accelerators

    International Nuclear Information System (INIS)

    Liu, Shi-Yao; Kurokawa, Shin-ichi

    1990-01-01

    Functional, hardware and software system architectures define the fundamental structure of control systems. Modelling is a protocol of system architecture used in system design. This paper reviews various modellings adopted in past ten years and suggests a new modelling for next generation accelerators. (author)

  9. Next Generation UV Coronagraph Instrumentation for Solar Cycle-24

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... New concepts for next generation instrumentation include imaging ultraviolet spectrocoronagraphs and large aperture ultraviolet coronagraph spectrometers. An imaging instrument would be the first to obtain absolute spectral line intensities of the extended corona over a wide field of view. Such images ...

  10. Power Electronics for the Next Generation Wind Turbine System

    DEFF Research Database (Denmark)

    Ma, Ke

    This book presents recent studies on the power electronics used for the next generation wind turbine system. Some criteria and tools for evaluating and improving the critical performances of the wind power converters have been proposed and established. The book addresses some emerging problems...

  11. Development of a framework for the neutronics analysis system for next generation (3)

    International Nuclear Information System (INIS)

    Yokoyama, Kenji; Hirai, Yasushi; Hyoudou, Hideaki; Tatsumi, Masahiro

    2010-02-01

    Development of innovative analysis methods and models in fundamental studies for next-generation nuclear reactor systems is in progress. In order to efficiently and effectively reflect the latest analysis methods and models to primary design of commercial reactor and/or in-core fuel management for power reactors, a next-generation analysis system MARBLE has been developed. The next-generation analysis system provides solutions to the following requirements: (1) flexibility, extensibility and user-friendliness that can apply new methods and models rapidly and effectively for fundamental studies, (2) quantitative proof of solution accuracy and adaptive scoping range for design studies, (3) coupling analysis among different study domains for the purpose of rationalization of plant systems and improvement of reliability, (4) maintainability and reusability for system extensions for the purpose of total quality management and development efficiency. The next-generation analysis system supports many fields, such as thermal-hydraulic analysis, structure analysis, reactor physics etc., and now we are studying reactor physics analysis system for fast reactor in advance. As for reactor physics analysis methods for fast reactor, we have established the JUPITER standard analysis methods based on the past study. But, there has been a problem of extreme inefficiency due to lack of functionality in the conventional analysis system when changing analysis targets and/or modeling levels. That is why, we have developed the next-generation analysis system for reactor physics which reproduces the JUPITER standard analysis method that has been developed so far and newly realizes burnup and design analysis for fast reactor and functions for cross section adjustment. In the present study, we examined in detail the existing design and implementation of ZPPR critical experiment analysis database followed by unification of models within the framework of the next-generation analysis system by

  12. The CMS Level-1 Trigger Barrel Track Finder

    International Nuclear Information System (INIS)

    Ero, J.; Wulz, C.; Evangelou, I.; Flouris, G.; Foudas, C.; Loukas, N.; Manthos, N.; Papadopoulos, I.; Paradas, E.; Guiducci, L.; Sotiropoulos, S.; Sphicas, P.; Triossi, A.

    2016-01-01

    The design and performance of the upgraded CMS Level-1 Trigger Barrel Muon Track Finder (BMTF) is presented. Monte Carlo simulation data as well as cosmic ray data from a CMS muon detector slice test have been used to study in detail the performance of the new track finder. The design architecture is based on twelve MP7 cards each of which uses a Xilinx Virtex-7 FPGA and can receive and transmit data at 10 Gbps from 72 input and 72 output fibers. According to the CMS Trigger Upgrade TDR the BMTF receives trigger primitive data which are computed using both RPC and DT data and transmits data from a number of muon candidates to the upgraded Global Muon Trigger. Results from detailed studies of comparisons between the BMTF algorithm results and the results of a C++ emulator are also presented. The new BMTF will be commissioned for data taking in 2016

  13. Next-generation Sequencing-based genomic profiling: Fostering innovation in cancer care?

    Directory of Open Access Journals (Sweden)

    Gustavo S. Fernandes

    Full Text Available OBJECTIVES: With the development of next-generation sequencing (NGS technologies, DNA sequencing has been increasingly utilized in clinical practice. Our goal was to investigate the impact of genomic evaluation on treatment decisions for heavily pretreated patients with metastatic cancer. METHODS: We analyzed metastatic cancer patients from a single institution whose cancers had progressed after all available standard-of-care therapies and whose tumors underwent next-generation sequencing analysis. We determined the percentage of patients who received any therapy directed by the test, and its efficacy. RESULTS: From July 2013 to December 2015, 185 consecutive patients were tested using a commercially available next-generation sequencing-based test, and 157 patients were eligible. Sixty-six patients (42.0% were female, and 91 (58.0% were male. The mean age at diagnosis was 52.2 years, and the mean number of pre-test lines of systemic treatment was 2.7. One hundred and seventy-seven patients (95.6% had at least one identified gene alteration. Twenty-four patients (15.2% underwent systemic treatment directed by the test result. Of these, one patient had a complete response, four (16.7% had partial responses, two (8.3% had stable disease, and 17 (70.8% had disease progression as the best result. The median progression-free survival time with matched therapy was 1.6 months, and the median overall survival was 10 months. CONCLUSION: We identified a high prevalence of gene alterations using an next-generation sequencing test. Although some benefit was associated with the matched therapy, most of the patients had disease progression as the best response, indicating the limited biological potential and unclear clinical relevance of this practice.

  14. Developing the next generation of nuclear workers at OPG

    International Nuclear Information System (INIS)

    Spekkens, P.

    2007-01-01

    This presentation is about developing the next generation of nuclear workers at Ontario Power Generation (OPG). Industry developments are creating urgent need to hire, train and retain new staff. OPG has an aggressive hiring campaign. Training organization is challenged to accommodate influx of new staff. Collaborating with colleges and universities is increasing the supply of qualified recruits with an interest in nuclear. Program for functional and leadership training have been developed. Knowledge retention is urgently required

  15. Heterogeneous next-generation wireless network interference model-and its applications

    KAUST Repository

    Mahmood, Nurul Huda; Yilmaz, Ferkan; Alouini, Mohamed-Slim; Ø ien, Geir Egil

    2014-01-01

    Next-generation wireless systems facilitating better utilisation of the scarce radio spectrum have emerged as a response to inefficient and rigid spectrum assignment policies. These are comprised of intelligent radio nodes that opportunistically

  16. Epidemiological Studies to Support the Development of Next Generation Influenza Vaccines.

    Science.gov (United States)

    Petrie, Joshua G; Gordon, Aubree

    2018-03-26

    The National Institute of Allergy and Infectious Diseases recently published a strategic plan for the development of a universal influenza vaccine. This plan focuses on improving understanding of influenza infection, the development of influenza immunity, and rational design of new vaccines. Epidemiological studies such as prospective, longitudinal cohort studies are essential to the completion of these objectives. In this review, we discuss the contributions of epidemiological studies to our current knowledge of vaccines and correlates of immunity, and how they can contribute to the development and evaluation of the next generation of influenza vaccines. These studies have been critical in monitoring the effectiveness of current influenza vaccines, identifying issues such as low vaccine effectiveness, reduced effectiveness among those who receive repeated vaccination, and issues related to egg adaptation during the manufacturing process. Epidemiological studies have also identified population-level correlates of protection that can inform the design and development of next generation influenza vaccines. Going forward, there is an enduring need for epidemiological studies to continue advancing knowledge of correlates of protection and the development of immunity, to evaluate and monitor the effectiveness of next generation influenza vaccines, and to inform recommendations for their use.

  17. Next generation multi-material 3D food printer concept

    NARCIS (Netherlands)

    Klomp, D.J.; Anderson, P.D.

    2017-01-01

    3D food printing is a new rapidly developing technology capable of creating food structures that are impossible to create with normal processing techniques. Challenges in this field are creating texture and multi-material food products. To address these challenges a next generation food printer will

  18. Next-generation sequencing approaches to understanding the oral microbiome

    NARCIS (Netherlands)

    Zaura, E.

    2012-01-01

    Until recently, the focus in dental research has been on studying a small fraction of the oral microbiome—so-called opportunistic pathogens. With the advent of next-generation sequencing (NGS) technologies, researchers now have the tools that allow for profiling of the microbiomes and metagenomes at

  19. Big Data Perspective and Challenges in Next Generation Networks

    Directory of Open Access Journals (Sweden)

    Kashif Sultan

    2018-06-01

    Full Text Available With the development towards the next generation cellular networks, i.e., 5G, the focus has shifted towards meeting the higher data rate requirements, potential of micro cells and millimeter wave spectrum. The goals for next generation networks are very high data rates, low latency and handling of big data. The achievement of these goals definitely require newer architecture designs, upgraded technologies with possible backward support, better security algorithms and intelligent decision making capability. In this survey, we identify the opportunities which can be provided by 5G networks and discuss the underlying challenges towards implementation and realization of the goals of 5G. This survey also provides a discussion on the recent developments made towards standardization, the architectures which may be potential candidates for deployment and the energy concerns in 5G networks. Finally, the paper presents a big data perspective and the potential of machine learning for optimization and decision making in 5G networks.

  20. Recent progress in nanostructured next-generation field emission devices

    International Nuclear Information System (INIS)

    Mittal, Gaurav; Lahiri, Indranil

    2014-01-01

    Field emission has been known to mankind for more than a century, and extensive research in this field for the last 40–50 years has led to development of exciting applications such as electron sources, miniature x-ray devices, display materials, etc. In the last decade, large-area field emitters were projected as an important material to revolutionize healthcare and medical devices, and space research. With the advent of nanotechnology and advancements related to carbon nanotubes, field emitters are demonstrating highly enhanced performance and novel applications. Next-generation emitters need ultra-high emission current density, high brightness, excellent stability and reproducible performance. Novel design considerations and application of new materials can lead to achievement of these capabilities. This article presents an overview of recent developments in this field and their effects on improved performance of field emitters. These advancements are demonstrated to hold great potential for application in next-generation field emission devices. (topical review)

  1. Recent progress in nanostructured next-generation field emission devices

    Science.gov (United States)

    Mittal, Gaurav; Lahiri, Indranil

    2014-08-01

    Field emission has been known to mankind for more than a century, and extensive research in this field for the last 40-50 years has led to development of exciting applications such as electron sources, miniature x-ray devices, display materials, etc. In the last decade, large-area field emitters were projected as an important material to revolutionize healthcare and medical devices, and space research. With the advent of nanotechnology and advancements related to carbon nanotubes, field emitters are demonstrating highly enhanced performance and novel applications. Next-generation emitters need ultra-high emission current density, high brightness, excellent stability and reproducible performance. Novel design considerations and application of new materials can lead to achievement of these capabilities. This article presents an overview of recent developments in this field and their effects on improved performance of field emitters. These advancements are demonstrated to hold great potential for application in next-generation field emission devices.

  2. Carrier ethernet network control plane based on the Next Generation Network

    DEFF Research Database (Denmark)

    Fu, Rong; Wang, Yanmeng; Berger, Michael Stubert

    2008-01-01

    This paper contributes on presenting a step towards the realization of Carrier Ethernet control plane based on the next generation network (NGN). Specifically, transport MPLS (T-MPLS) is taken as the transport technology in Carrier Ethernet. It begins with providing an overview of the evolving...... architecture of the next generation network (NGN). As an essential candidate among the NGN transport technologies, the definition of Carrier Ethernet (CE) is also introduced here. The second part of this paper depicts the contribution on the T-MPLS based Carrier Ethernet network with control plane based on NGN...... at illustrating the improvement of the Carrier Ethernet network with the NGN control plane....

  3. Development of source term evaluation method for Korean Next Generation Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Keon Jae; Cheong, Jae Hak; Park, Jin Baek; Kim, Guk Gee [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

    1997-10-15

    This project had investigate several design features of radioactive waste processing system and method to predict nuclide concentration at primary coolant basic concept of next generation reactor and safety goals at the former phase. In this project several prediction methods of source term are evaluated conglomerately and detailed contents of this project are : model evaluation of nuclide concentration at Reactor Coolant System, evaluation of primary and secondary coolant concentration of reference Nuclear Power Plant(NPP), investigation of prediction parameter of source term evaluation, basic parameter of PWR, operational parameter, respectively, radionuclide removal system and adjustment values of reference NPP, suggestion of source term prediction method of next generation NPP.

  4. Next generation of relativistic heavy ion accelerators

    International Nuclear Information System (INIS)

    Grunder, H.; Leemann, C.; Selph, F.

    1978-06-01

    Results are presented of exploratory and preliminary studies of a next generation of heavy ion accelerators. The conclusion is reached that useful luminosities are feasible in a colliding beam facility for relativistic heavy ions. Such an accelerator complex may be laid out in such a way as to provide extractebeams for fixed target operation, therefore allowing experimentation in an energy region overlapping with that presently available. These dual goals seem achievable without undue complications, or penalties with respect to cost and/or performance

  5. Thermonuclear ignition in the next generation tokamaks

    International Nuclear Information System (INIS)

    Johner, J.

    1989-04-01

    The extrapolation of experimental rules describing energy confinement and magnetohydrodynamic - stability limits, in known tokamaks, allow to show that stable thermonuclear ignition equilibria should exist in this configuration, if the product aB t x of the dimensions by a magnetic-field power is large enough. Quantitative application of this result to several next-generation tokamak projects show that those kinds of equilibria could exist in such devices, which would also have enough additional heating power to promote an effective accessible ignition

  6. DecoyFinder: an easy-to-use python GUI application for building target-specific decoy sets.

    Science.gov (United States)

    Cereto-Massagué, Adrià; Guasch, Laura; Valls, Cristina; Mulero, Miquel; Pujadas, Gerard; Garcia-Vallvé, Santiago

    2012-06-15

    Decoys are molecules that are presumed to be inactive against a target (i.e. will not likely bind to the target) and are used to validate the performance of molecular docking or a virtual screening workflow. The Directory of Useful Decoys database (http://dud.docking.org/) provides a free directory of decoys for use in virtual screening, though it only contains a limited set of decoys for 40 targets.To overcome this limitation, we have developed an application called DecoyFinder that selects, for a given collection of active ligands of a target, a set of decoys from a database of compounds. Decoys are selected if they are similar to active ligands according to five physical descriptors (molecular weight, number of rotational bonds, total hydrogen bond donors, total hydrogen bond acceptors and the octanol-water partition coefficient) without being chemically similar to any of the active ligands used as an input (according to the Tanimoto coefficient between MACCS fingerprints). To the best of our knowledge, DecoyFinder is the first application designed to build target-specific decoy sets. A complete description of the software is included on the application home page. A validation of DecoyFinder on 10 DUD targets is provided as Supplementary Table S1. DecoyFinder is freely available at http://URVnutrigenomica-CTNS.github.com/DecoyFinder.

  7. Next Generation Antibody Therapeutics Using Bispecific Antibody Technology.

    Science.gov (United States)

    Igawa, Tomoyuki

    2017-01-01

    Nearly fifty monoclonal antibodies have been approved to date, and the market for monoclonal antibodies is expected to continue to grow. Since global competition in the field of antibody therapeutics is intense, we need to establish novel antibody engineering technologies to provide true benefit for patients, with differentiated product values. Bispecific antibodies are among the next generation of antibody therapeutics that can bind to two different target antigens by the two arms of immunoglobulin G (IgG) molecule, and are thus believed to be applicable to various therapeutic needs. Until recently, large scale manufacturing of human IgG bispecific antibody was impossible. We have established a technology, named asymmetric re-engineering technology (ART)-Ig, to enable large scale manufacturing of bispecific antibodies. Three examples of next generation antibody therapeutics using ART-Ig technology are described. Recent updates on bispecific antibodies against factor IXa and factor X for the treatment of hemophilia A, bispecific antibodies against a tumor specific antigen and T cell surface marker CD3 for cancer immunotherapy, and bispecific antibodies against two different epitopes of soluble antigen with pH-dependent binding property for the elimination of soluble antigen from plasma are also described.

  8. Feasibility and application on steam injector for next-generation reactor

    International Nuclear Information System (INIS)

    Narabayashi, Tadashi; Ishiyama, Takenori; Miyano, Hiroshi; Nei, Hiromichi; Shioiri, Akio

    1991-01-01

    A feasibility study has been conducted on steam injector for a next generation reactor. The steam injector is a simple, compact passive device for water injection, such as Passive Core Injection System (PCIS) of Passive Containment Cooling System (PCCS), because of easy start-up without an AC power. An analysis model for a steam injector characteristics has been developed, and investigated with a visualized fundamental test for a two-stage Steam Injector System (SIS) for PCIS and a one-stage low pressure SIS for PCCS. The test results showed good agreement with the analysis results. The analysis and the test results showed the SIS could work over a very wide range of the steam pressure, and is applicable for PCIS or PCCS in the next generation reactors. (author)

  9. Results of Analyses of the Next Generation Solvent for Parsons

    International Nuclear Information System (INIS)

    Peters, T.; Washington, A.; Fink, S.

    2012-01-01

    Savannah River National Laboratory (SRNL) prepared a nominal 150 gallon batch of Next Generation Solvent (NGS) for Parsons. This material was then analyzed and tested for cesium mass transfer efficiency. The bulk of the results indicate that the solvent is qualified as acceptable for use in the upcoming pilot-scale testing at Parsons Technology Center. This report describes the analysis and testing of a batch of Next Generation Solvent (NGS) prepared in support of pilot-scale testing in the Parsons Technology Center. A total of ∼150 gallons of NGS solvent was prepared in late November of 2011. Details for the work are contained in a controlled laboratory notebook. Analysis of the Parsons NGS solvent indicates that the material is acceptable for use. SRNL is continuing to improve the analytical method for the guanidine.

  10. Modeling and Implementation of Multi-Position Non-Continuous Rotation Gyroscope North Finder

    Directory of Open Access Journals (Sweden)

    Jun Luo

    2016-09-01

    Full Text Available Even when the Global Positioning System (GPS signal is blocked, a rate gyroscope (gyro north finder is capable of providing the required azimuth reference information to a certain extent. In order to measure the azimuth between the observer and the north direction very accurately, we propose a multi-position non-continuous rotation gyro north finding scheme. Our new generalized mathematical model analyzes the elements that affect the azimuth measurement precision and can thus provide high precision azimuth reference information. Based on the gyro’s principle of detecting a projection of the earth rotation rate on its sensitive axis and the proposed north finding scheme, we are able to deduct an accurate mathematical model of the gyro outputs against azimuth with the gyro and shaft misalignments. Combining the gyro outputs model and the theory of propagation of uncertainty, some approaches to optimize north finding are provided, including reducing the gyro bias error, constraining the gyro random error, increasing the number of rotation points, improving rotation angle measurement precision, decreasing the gyro and the shaft misalignment angles. According them, a north finder setup is built and the azimuth uncertainty of 18” is obtained. This paper provides systematic theory for analyzing the details of the gyro north finder scheme from simulation to implementation. The proposed theory can guide both applied researchers in academia and advanced practitioners in industry for designing high precision robust north finder based on different types of rate gyroscopes.

  11. The Voronoi Tessellation cluster finder in 2+1 dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Soares-Santos, Marcelle; /Fermilab /Sao Paulo U.; de Carvalho, Reinaldo R.; /Sao Jose, INPE; Annis, James; /Fermilab; Gal, Roy R.; /Hawaii U.; La Barbera, Francesco; /Capodimonte Observ.; Lopes, Paulo A.A.; /Valongo Observ.; Wechsler, Risa H.; Busha, Michael T.; Gerke, Brian F.; /SLAC /KIPAC, Menlo Park

    2010-11-01

    We present a detailed description of the Voronoi Tessellation (VT) cluster finder algorithm in 2+1 dimensions, which improves on past implementations of this technique. The need for cluster finder algorithms able to produce reliable cluster catalogs up to redshift 1 or beyond and down to 10{sup 13.5} solar masses is paramount especially in light of upcoming surveys aiming at cosmological constraints from galaxy cluster number counts. We build the VT in photometric redshift shells and use the two-point correlation function of the galaxies in the field to both determine the density threshold for detection of cluster candidates and to establish their significance. This allows us to detect clusters in a self-consistent way without any assumptions about their astrophysical properties. We apply the VT to mock catalogs which extend to redshift 1.4 reproducing the {Lambda}CDM cosmology and the clustering properties observed in the Sloan Digital Sky Survey data. An objective estimate of the cluster selection function in terms of the completeness and purity as a function of mass and redshift is as important as having a reliable cluster finder. We measure these quantities by matching the VT cluster catalog with the mock truth table. We show that the VT can produce a cluster catalog with completeness and purity >80% for the redshift range up to {approx}1 and mass range down to {approx}10{sup 13.5} solar masses.

  12. The Voronoi Tessellation Cluster Finder in 2 1 Dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Soares-Santos, Marcelle; /Fermilab /Sao Paulo U.; de Carvalho, Reinaldo R.; /Sao Jose, INPE; Annis, James; /Fermilab; Gal, Roy R.; /Hawaii U.; La Barbera, Francesco; /Capodimonte Observ.; Lopes, Paulo A.A.; /Valongo Observ.; Wechsler, Risa H.; Busha, Michael T.; Gerke, Brian F.; /SLAC /KIPAC, Menlo Park

    2011-06-23

    We present a detailed description of the Voronoi Tessellation (VT) cluster finder algorithm in 2+1 dimensions, which improves on past implementations of this technique. The need for cluster finder algorithms able to produce reliable cluster catalogs up to redshift 1 or beyond and down to 10{sup 13.5} solar masses is paramount especially in light of upcoming surveys aiming at cosmological constraints from galaxy cluster number counts. We build the VT in photometric redshift shells and use the two-point correlation function of the galaxies in the field to both determine the density threshold for detection of cluster candidates and to establish their significance. This allows us to detect clusters in a self-consistent way without any assumptions about their astrophysical properties. We apply the VT to mock catalogs which extend to redshift 1.4 reproducing the ?CDM cosmology and the clustering properties observed in the Sloan Digital Sky Survey data. An objective estimate of the cluster selection function in terms of the completeness and purity as a function of mass and redshift is as important as having a reliable cluster finder. We measure these quantities by matching the VT cluster catalog with the mock truth table. We show that the VT can produce a cluster catalog with completeness and purity >80% for the redshift range up to {approx}1 and mass range down to {approx}10{sup 13.5} solar masses.

  13. THE VORONOI TESSELLATION CLUSTER FINDER IN 2+1 DIMENSIONS

    International Nuclear Information System (INIS)

    Soares-Santos, Marcelle; Annis, James; De Carvalho, Reinaldo R.; Gal, Roy R.; La Barbera, Francesco; Lopes, Paulo A. A.; Wechsler, Risa H.; Busha, Michael T.; Gerke, Brian F.

    2011-01-01

    We present a detailed description of the Voronoi Tessellation (VT) cluster finder algorithm in 2+1 dimensions, which improves on past implementations of this technique. The need for cluster finder algorithms able to produce reliable cluster catalogs up to redshift 1 or beyond and down to 10 13.5 solar masses is paramount especially in light of upcoming surveys aiming at cosmological constraints from galaxy cluster number counts. We build the VT in photometric redshift shells and use the two-point correlation function of the galaxies in the field to both determine the density threshold for detection of cluster candidates and to establish their significance. This allows us to detect clusters in a self-consistent way without any assumptions about their astrophysical properties. We apply the VT to mock catalogs which extend to redshift 1.4 reproducing the ΛCDM cosmology and the clustering properties observed in the Sloan Digital Sky Survey data. An objective estimate of the cluster selection function in terms of the completeness and purity as a function of mass and redshift is as important as having a reliable cluster finder. We measure these quantities by matching the VT cluster catalog with the mock truth table. We show that the VT can produce a cluster catalog with completeness and purity >80% for the redshift range up to ∼1 and mass range down to ∼10 13.5 solar masses.

  14. Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data

    NARCIS (Netherlands)

    K.M. Hettne (Kristina); J. Boorsma (Jeffrey); D.A.M. van Dartel (Dorien A M); J.J. Goeman (Jelle); E.C. de Jong (Esther); A.H. Piersma (Aldert); R.H. Stierum (Rob); J. Kleinjans (Jos); J.A. Kors (Jan)

    2013-01-01

    textabstractBackground: Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited. We hypothesize that more gene sets can be created by next-generation text mining (next-gen TM), and that these can be used with

  15. The Potential for Volcanism and Tectonics on Extrasolar Terrestrial Planets

    Science.gov (United States)

    Quick, Lynnae C.; Roberge, Aki

    2018-01-01

    JWST and other next-generation space telescopes (e.g., LUVOIR, HabEx, & OST) will usher in a new era of exoplanet characterization that may lead to the identification of habitable, Earth-like worlds. Like the planets and moons in our solar system, the surfaces and interiors of terrestrial exoplanets may be shaped by volcanism and tectonics (Fu et al., 2010; van Summeren et al., 2011; Henning and Hurford, 2014). The magnitude and rate of occurrence of these dynamic processes can either facilitate or preclude the existence of habitable environments. Likewise, it has been suggested that detections of cryovolcanism on icy exoplanets, in the form of geyser-like plumes, could indicate the presence of subsurface oceans (Quick et al., 2017).The presence of volcanic and tectonic activity on solid exoplanets will be intimately linked to planet size and heat output in the form of radiogenic and/or tidal heating. In order to place bounds on the potential for such activity, we estimated the heat output of a variety of exoplanets observed by Kepler. We considered planets whose masses and radii range from 0.067 ME (super-Ganymede) to 8 ME (super-Earth), and 0.5 to 1.8 RE, respectively. These heat output estimates were then compared to those of planets, moons, and dwarf planets in our solar system for which we have direct evidence for the presence/absence of volcanic and tectonic activity. After exoplanet heating rates were estimated, depths to putative molten layers in their interiors were also calculated. For planets such as TRAPPIST-1h, whose densities, orbital parameters, and effective temperatures are consistent with the presence of significant amounts of H2O (Luger et al., 2017), these calculations reveal the depths to internal oceans which may serve as habitable niches beneath surface ice layers.

  16. The "Next Generation Science Standards" and the Life Sciences

    Science.gov (United States)

    Bybee, Rodger W.

    2013-01-01

    Publication of the "Next Generation Science Standards" will be just short of two decades since publication of the "National Science Education Standards" (NRC 1996). In that time, biology and science education communities have advanced, and the new standards will reflect that progress (NRC 1999, 2007, 2009; Kress and Barrett…

  17. Development and implementation of a 'Mental Health Finder' software tool within an electronic medical record system.

    Science.gov (United States)

    Swan, D; Hannigan, A; Higgins, S; McDonnell, R; Meagher, D; Cullen, W

    2017-02-01

    In Ireland, as in many other healthcare systems, mental health service provision is being reconfigured with a move toward more care in the community, and particularly primary care. Recording and surveillance systems for mental health information and activities in primary care are needed for service planning and quality improvement. We describe the development and initial implementation of a software tool ('mental health finder') within a widely used primary care electronic medical record system (EMR) in Ireland to enable large-scale data collection on the epidemiology and management of mental health and substance use problems among patients attending general practice. In collaboration with the Irish Primary Care Research Network (IPCRN), we developed the 'Mental Health Finder' as a software plug-in to a commonly used primary care EMR system to facilitate data collection on mental health diagnoses and pharmacological treatments among patients. The finder searches for and identifies patients based on diagnostic coding and/or prescribed medicines. It was initially implemented among a convenience sample of six GP practices. Prevalence of mental health and substance use problems across the six practices, as identified by the finder, was 9.4% (range 6.9-12.7%). 61.9% of identified patients were female; 25.8% were private patients. One-third (33.4%) of identified patients were prescribed more than one class of psychotropic medication. Of the patients identified by the finder, 89.9% were identifiable via prescribing data, 23.7% via diagnostic coding. The finder is a feasible and promising methodology for large-scale data collection on mental health problems in primary care.

  18. Electric vehicle charge patterns and the electricity generation mix and competitiveness of next generation vehicles

    International Nuclear Information System (INIS)

    Masuta, Taisuke; Murata, Akinobu; Endo, Eiichi

    2014-01-01

    Highlights: • The energy system of whole of Japan is analyzed in this study. • An advanced model based on MARKAL is used for the energy system analysis. • The impact of charge patterns of EVs on electricity generation mix is evaluated. • Technology competitiveness of the next generation vehicles is also evaluated. - Abstract: The nuclear accident of 2011 brought about a reconsideration of the future electricity generation mix of power systems in Japan. A debate on whether to phase out nuclear power plants and replace them with renewable energy sources is taking place. Demand-side management becomes increasingly important in future Japanese power systems with a large-scale integration of renewable energy sources. This paper considers the charge control of electric vehicles (EVs) through demand-side management. There have been many studies of the control or operation methods of EVs known as vehicle-to-grid (V2G), and it is important to evaluate both their short-term and long-term operation. In this study, we employ energy system to evaluate the impact of the charge patterns of EVs on both the electricity generation mix and the technology competitiveness of the next generation vehicles. An advanced energy system model based on Market Allocation (MARKAL) is used to consider power system control in detail

  19. CLEVER: Clique-Enumerating Variant Finder

    NARCIS (Netherlands)

    Marschall, T.; Costa, I.; Canzar, S.; bauer, m; Klau, G.W.; Schliep, A.; Schönhuth, A.

    2012-01-01

    Motivation: Next-generation sequencing techniques have facilitated a large-scale analysis of human genetic variation. Despite the advances in sequencing speed, the computational discovery of structural variants is not yet standard. It is likely that many variants have remained undiscovered in most

  20. Modeling the video distribution link in the Next Generation Optical Access Networks

    International Nuclear Information System (INIS)

    Amaya, F; Cardenas, A; Tafur, I

    2011-01-01

    In this work we present a model for the design and optimization of the video distribution link in the next generation optical access network. We analyze the video distribution performance in a SCM-WDM link, including the noise, the distortion and the fiber optic nonlinearities. Additionally, we consider in the model the effect of distributed Raman amplification, used to extent the capacity and the reach of the optical link. In the model, we use the nonlinear Schroedinger equation with the purpose to obtain capacity limitations and design constrains of the next generation optical access networks.

  1. International Deep Planet Survey, 317 stars to determine the wide-separated planet frequency

    Science.gov (United States)

    Galicher, R.; Marois, C.; Macintosh, B.; Zuckerman, B.; Song, I.; Barman, T.; Patience, J.

    2013-09-01

    Since 2000, more than 300 nearby young stars were observed for the International Deep Planet Survey with adaptive optics systems at Gemini (NIRI/NICI), Keck (Nirc2), and VLT (Naco). Massive young AF stars were included in our sample whereas they have generally been neglected in first generation surveys because the contrast and target distances are less favorable to image substellar companions. The most significant discovery of the campaign is the now well-known HR 8799 multi-planet system. This remarkable finding allows, for the first time, an estimate of the Jovians planet population at large separations (further than a few AUs) instead of deriving upper limits. During my presentation, I will present the survey showing images of multiple stars and planets. I will then propose a statistic study of the observed stars deriving constraints on the Jupiter-like planet frequency at large separations.

  2. The study of methodologies of software development for the next generation of HEP detector software

    International Nuclear Information System (INIS)

    Ding Yuzheng; Wang Taijie; Dai Guiliang

    1997-01-01

    The author discusses the characteristics of the next generation of HEP (High Energy Physics) detector software, and describes the basic strategy for the usage of object oriented methodologies, languages and tools in the development of the next generation of HEP detector software

  3. Automated finder for the critical condition on the linear stability of fluid motions

    International Nuclear Information System (INIS)

    Fujimura, Kaoru

    1990-03-01

    An automated finder routine for the critical condition on the linear stability of fluid motions is proposed. The Newton-Raphson method was utilized for an iteration to solve nonlinear eigenvalue problems appeared in the analysis. The routine was applied to linear stability problem of a free convection between vertical parallel plates with different non-uniform temperatures as well as a plane Poiseuille flow. An efficiency of the finder routine is demonstrated for several parameter sets, numerically. (author)

  4. Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data

    NARCIS (Netherlands)

    Hettne, K.M.; Boorsma, A.; Dartel, D.A. van; Goeman, J.J.; Jong, E. de; Piersma, A.H.; Stierum, R.H.; Kleinjans, J.C.; Kors, J.A.

    2013-01-01

    BACKGROUND: Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited. We hypothesize that more gene sets can be created by next-generation text mining (next-gen TM), and that these can be used with gene set

  5. Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data

    NARCIS (Netherlands)

    Hettne, K.M.; Boorsma, A.; Dartel, van D.A.M.; Goeman, J.J.; Jong, de E.; Piersma, A.H.; Stierum, R.H.; Kleinjans, J.C.; Kors, J.A.

    2013-01-01

    Background: Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited. We hypothesize that more gene sets can be created by next-generation text mining (next-gen TM), and that these can be used with gene set

  6. Multiple Access Techniques for Next Generation Wireless: Recent Advances and Future Perspectives

    Directory of Open Access Journals (Sweden)

    Shree Krishna Sharma

    2016-01-01

    Full Text Available The advances in multiple access techniques has been one of the key drivers in moving from one cellular generation to another. Starting from the first generation, several multiple access techniques have been explored in different generations and various emerging multiplexing/multiple access techniques are being investigated for the next generation of cellular networks. In this context, this paper first provides a detailed review on the existing Space Division Multiple Access (SDMA related works. Subsequently, it highlights the main features and the drawbacks of various existing and emerging multiplexing/multiple access techniques. Finally, we propose a novel concept of clustered orthogonal signature division multiple access for the next generation of cellular networks. The proposed concept envisions to employ joint antenna coding in order to enhance the orthogonality of SDMA beams with the objective of enhancing the spectral efficiency of future cellular networks.

  7. Next generation science standards available for comment

    Science.gov (United States)

    Asher, Pranoti

    2012-05-01

    The first public draft of the Next Generation Science Standards (NGSS) is now available for public comment. Feedback on the standards is sought from people who have a stake in science education, including individuals in the K-12, higher education, business, and research communities. Development of NGSS is a state-led effort to define the content and practices students need to learn from kindergarten through high school. NGSS will be based on the U.S. National Research Council's reportFramework for K-12 Science Education.

  8. Design Principles of Next-Generation Digital Gaming for Education.

    Science.gov (United States)

    Squire, Kurt; Jenkins, Henry; Holland, Walter; Miller, Heather; O'Driscoll, Alice; Tan, Katie Philip; Todd, Katie.

    2003-01-01

    Discusses the rapid growth of digital games, describes research at MIT that is exploring the potential of digital games for supporting learning, and offers hypotheses about the design of next-generation educational video and computer games. Highlights include simulations and games; and design principles, including context and using information to…

  9. Identification and Characterization of Key Human Performance Issues and Research in the Next Generation Air Transportation System (NextGen)

    Science.gov (United States)

    Lee, Paul U.; Sheridan, Tom; Poage, james L.; Martin, Lynne Hazel; Jobe, Kimberly K.

    2010-01-01

    This report identifies key human-performance-related issues associated with Next Generation Air Transportation System (NextGen) research in the NASA NextGen-Airspace Project. Four Research Focus Areas (RFAs) in the NextGen-Airspace Project - namely Separation Assurance (SA), Airspace Super Density Operations (ASDO), Traffic Flow Management (TFM), and Dynamic Airspace Configuration (DAC) - were examined closely. In the course of the research, it was determined that the identified human performance issues needed to be analyzed in the context of NextGen operations rather than through basic human factors research. The main gaps in human factors research in NextGen were found in the need for accurate identification of key human-systems related issues within the context of specific NextGen concepts and better design of the operational requirements for those concepts. By focusing on human-system related issues for individual concepts, key human performance issues for the four RFAs were identified and described in this report. In addition, mixed equipage airspace with components of two RFAs were characterized to illustrate potential human performance issues that arise from the integration of multiple concepts.

  10. 75 FR 82387 - Next Generation Risk Assessment Public Dialogue Conference

    Science.gov (United States)

    2010-12-30

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9246-7] Next Generation Risk Assessment Public Dialogue Conference AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of Public Dialogue Conference... methods with the National Institutes of Environmental Health Sciences' National Toxicology Program, Center...

  11. Reflected Light from Giant Planets in Habitable Zones: Tapping into the Power of the Cross-Correlation Function.

    Science.gov (United States)

    Martins, J H C; Santos, N C; Figueira, P; Melo, C

    2016-11-01

    The direct detection of reflected light from exoplanets is an excellent probe for the characterization of their atmospheres. The greatest challenge for this task is the low planet-to-star flux ratio, which even in the most favourable case is of the order of 10 -4 in the optical. This ratio decreases even more for planets in their host's habitable zone, typically lower than 10 -7 . To reach the signal-to-noise level required for such detections, we propose to unleash the power of the Cross Correlation Function in combination with the collecting power of next generation observing facilities. The technique we propose has already yielded positive results by detecting the reflected spectral signature of 51 Pegasi b (see Martins et al. 2015). In this work, we attempted to infer the number of hours required for the detection of several planets in their host's habitable zone using the aforementioned technique from theoretical EELT observations. Our results show that for 5 of the selected planets it should be possible to directly recover their reflected spectral signature.

  12. Quantitative miRNA expression analysis: comparing microarrays with next-generation sequencing

    DEFF Research Database (Denmark)

    Willenbrock, Hanni; Salomon, Jesper; Søkilde, Rolf

    2009-01-01

    Recently, next-generation sequencing has been introduced as a promising, new platform for assessing the copy number of transcripts, while the existing microarray technology is considered less reliable for absolute, quantitative expression measurements. Nonetheless, so far, results from the two...... technologies have only been compared based on biological data, leading to the conclusion that, although they are somewhat correlated, expression values differ significantly. Here, we use synthetic RNA samples, resembling human microRNA samples, to find that microarray expression measures actually correlate...... better with sample RNA content than expression measures obtained from sequencing data. In addition, microarrays appear highly sensitive and perform equivalently to next-generation sequencing in terms of reproducibility and relative ratio quantification....

  13. RIPng- A next Generation Routing Protocal (IPv6) | Falaye | Journal ...

    African Journals Online (AJOL)

    ... Information Protocol Next Generation (RIPng) owing to the current depletion rate of IPv4. ... that support the Internet Protocol Version 6 (IPv6).addressing scheme. ... A brief history is given; its various versions are discussed, and detailed ...

  14. Clinical utility of a 377 gene custom next-generation sequencing ...

    Indian Academy of Sciences (India)

    JEN BEVILACQUA

    2017-07-26

    Jul 26, 2017 ... Clinical utility of a 377 gene custom next-generation sequencing epilepsy panel ... number of genes, making it a very attractive option for a condition as .... clinical value of various test offerings to guide decision making.

  15. AgMIP: Next Generation Models and Assessments

    Science.gov (United States)

    Rosenzweig, C.

    2014-12-01

    Next steps in developing next-generation crop models fall into several categories: significant improvements in simulation of important crop processes and responses to stress; extension from simplified crop models to complex cropping systems models; and scaling up from site-based models to landscape, national, continental, and global scales. Crop processes that require major leaps in understanding and simulation in order to narrow uncertainties around how crops will respond to changing atmospheric conditions include genetics; carbon, temperature, water, and nitrogen; ozone; and nutrition. The field of crop modeling has been built on a single crop-by-crop approach. It is now time to create a new paradigm, moving from 'crop' to 'cropping system.' A first step is to set up the simulation technology so that modelers can rapidly incorporate multiple crops within fields, and multiple crops over time. Then the response of these more complex cropping systems can be tested under different sustainable intensification management strategies utilizing the updated simulation environments. Model improvements for diseases, pests, and weeds include developing process-based models for important diseases, frameworks for coupling air-borne diseases to crop models, gathering significantly more data on crop impacts, and enabling the evaluation of pest management strategies. Most smallholder farming in the world involves integrated crop-livestock systems that cannot be represented by crop modeling alone. Thus, next-generation cropping system models need to include key linkages to livestock. Livestock linkages to be incorporated include growth and productivity models for grasslands and rangelands as well as the usual annual crops. There are several approaches for scaling up, including use of gridded models and development of simpler quasi-empirical models for landscape-scale analysis. On the assessment side, AgMIP is leading a community process for coordinated contributions to IPCC AR6

  16. The Next Generation Science Standards: The Features and Challenges

    Science.gov (United States)

    Pruitt, Stephen L.

    2014-01-01

    Beginning in January of 2010, the Carnegie Corporation of New York funded a two-step process to develop a new set of state developed science standards intended to prepare students for college and career readiness in science. These new internationally benchmarked science standards, the Next Generation Science Standards (NGSS) were completed in…

  17. The STAR cluster-finder ASIC

    Energy Technology Data Exchange (ETDEWEB)

    Botlo, M.; LeVine, M.J.; Scheetz, R.A.; Schulz, M.W. [Brookhaven National Lab., Upton, NY (United States); Short, P.; Woods, J. [InnovASIC, Inc., Albuquerque, NM (United States); Crosetto, D. [Rice Univ., Houston, TX (United States). Bonner Nuclear Lab.

    1997-12-01

    STAR is a large TPC-based experiment at RHIC, the relativistic heavy ion collider at Brookhaven National Laboratory. The STAR experiment reads out a TPC and an SVT (silicon vertex tracker), both of which require in-line pedestal subtraction, compression of ADC values from 10-bit to 8-bit, and location of time sequences representing responses to charged-particle tracks. The STAR cluster finder ASIC responds to all of these needs. Pedestal subtraction and compression are performed using lookup tables in attached RAM. The authors describe its design and implementation, as well as testing methodology and results of tests performed on foundry prototypes.

  18. Career Advancement: Meeting the Challenges Confronting the Next Generation of Endocrinologists and Endocrine Researchers.

    Science.gov (United States)

    Santen, Richard J; Joham, Anju; Fishbein, Lauren; Vella, Kristen R; Ebeling, Peter R; Gibson-Helm, Melanie; Teede, Helena

    2016-12-01

    Challenges and opportunities face the next generation (Next-Gen) of endocrine researchers and clinicians, the lifeblood of the field of endocrinology for the future. A symposium jointly sponsored by The Endocrine Society and the Endocrine Society of Australia was convened to discuss approaches to addressing the present and future Next-Gen needs. Data collection by literature review, assessment of previously completed questionnaires, commissioning of a new questionnaire, and summarization of symposium discussions were studied. Next-Gen endocrine researchers face diminishing grant funding in inflation-adjusted terms. The average age of individuals being awarded their first independent investigator funding has increased to age 45 years. For clinicians, a workforce gap exists between endocrinologists needed and those currently trained. Clinicians in practice are increasingly becoming employees of integrated hospital systems, resulting in greater time spent on nonclinical issues. Workforce data and published reviews identify challenges specifically related to early career women in endocrinology. Strategies to Address Issues: Recommendations encompassed the areas of grant support for research, mentoring, education, templates for career development, specific programs for Next-Gen members by senior colleagues as outlined in the text, networking, team science, and life/work integration. Endocrine societies focusing on Next-Gen members provide a powerful mechanism to support these critical areas. A concerted effort to empower, train, and support the next generation of clinical endocrinologists and endocrine researchers is necessary to ensure the viability and vibrancy of our discipline and to optimize our contributions to improving health outcomes. Collaborative engagement of endocrine societies globally will be necessary to support our next generation moving forward.

  19. "ASTRO 101" Course Materials 2.0: Next Generation Lecture Tutorials and Beyond

    Science.gov (United States)

    Slater, Stephanie; Grazier, Kevin

    2015-01-01

    Early efforts to create course materials were often local in scale and were based on "gut instinct," and classroom experience and observation. While subsequent efforts were often based on those same instincts and observations of classrooms, they also incorporated the results of many years of education research. These "second generation" course materials, such as lecture tutorials, relied heavily on research indicating that instructors need to actively engage students in the learning process. While imperfect, these curricular innovations, have provided evidence that research-based materials can be constructed, can easily be disseminated to a broad audience, and can provide measureable improvement in student learning across many settings. In order to improve upon this prior work, next generation materials must build upon the strengths of these innovations while engineering in findings from education research, cognitive science, and instructor feedback. A next wave of materials, including a set of next generation lecture tutorials, have been constructed with attention to the body of research on student motivation, and cognitive load; and they are responsive to our body of knowledge on learning difficulties related to specific content in the domain. From instructor feedback, these materials have been constructed to have broader coverage of the materials typically taught in an ASTRO 101 course, to take less class time, and to be more affordable for students. This next generation of lecture tutorials may serve as a template of the ways in which course materials can be reengineered to respond to current instructor and student needs.

  20. Next generation Zero-Code control system UI

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    Developing ergonomic user interfaces for control systems is challenging, especially during machine upgrade and commissioning where several small changes may suddenly be required. Zero-code systems, such as *Inspector*, provide agile features for creating and maintaining control system interfaces. More so, these next generation Zero-code systems bring simplicity and uniformity and brake the boundaries between Users and Developers. In this talk we present *Inspector*, a CERN made Zero-code application development system, and we introduce the major differences and advantages of using Zero-code control systems to develop operational UI.

  1. Beamstrahlung spectra in next generation linear colliders

    Energy Technology Data Exchange (ETDEWEB)

    Barklow, T.; Chen, P. (Stanford Linear Accelerator Center, Menlo Park, CA (United States)); Kozanecki, W. (DAPNIA-SPP, CEN-Saclay (France))

    1992-04-01

    For the next generation of linear colliders, the energy loss due to beamstrahlung during the collision of the e{sup +}e{sup {minus}} beams is expected to substantially influence the effective center-of-mass energy distribution of the colliding particles. In this paper, we first derive analytical formulae for the electron and photon energy spectra under multiple beamstrahlung processes, and for the e{sup +}e{sup {minus}} and {gamma}{gamma} differential luminosities. We then apply our formulation to various classes of 500 GeV e{sup +}e{sup {minus}} linear collider designs currently under study.

  2. Thermal management of next-generation contact-cooled synchrotron x-ray mirrors

    Energy Technology Data Exchange (ETDEWEB)

    Khounsary, A.

    1999-10-29

    In the past decade, several third-generation synchrotrons x-ray sources have been constructed and commissioned around the world. Many of the major problems in the development and design of the optical components capable of handling the extremely high heat loads of the generated x-ray beams have been resolved. It is expected, however, that in the next few years even more powerful x-ray beams will be produced at these facilities, for example, by increasing the particle beam current. In this paper, the design of a next generation of synchrotron x-ray mirrors is discussed. The author shows that the design of contact-cooled mirrors capable of handing x-ray beam heat fluxes in excess of 500 W/mm{sup 2} - or more than three times the present level - is well within reach, and the limiting factor is the thermal stress rather then thermally induced slope error.

  3. Proceedings of the international workshop on next-generation linear colliders

    International Nuclear Information System (INIS)

    Riordan, M.

    1988-12-01

    This report contains papers on the next-generation of linear colliders. The particular areas of discussion are: parameters; beam dynamics and wakefields; damping rings and sources; rf power sources; accelerator structures; instrumentation; final focus; and review of beam-beam interaction

  4. C-Arc: A Novel Architecture for Next Generation Context- Aware ...

    African Journals Online (AJOL)

    In this paper, the common architecture principles of context-aware systems are presented and the crucial contextaware architecture issues to support the next generation context-aware systems which will enable seamless service provisioning in heterogeneous, dynamically varying computing and communication ...

  5. Proceedings of the international workshop on next-generation linear colliders

    Energy Technology Data Exchange (ETDEWEB)

    Riordan, M. (ed.)

    1988-12-01

    This report contains papers on the next-generation of linear colliders. The particular areas of discussion are: parameters; beam dynamics and wakefields; damping rings and sources; rf power sources; accelerator structures; instrumentation; final focus; and review of beam-beam interaction.

  6. Tablet—next generation sequence assembly visualization

    Science.gov (United States)

    Milne, Iain; Bayer, Micha; Cardle, Linda; Shaw, Paul; Stephen, Gordon; Wright, Frank; Marshall, David

    2010-01-01

    Summary: Tablet is a lightweight, high-performance graphical viewer for next-generation sequence assemblies and alignments. Supporting a range of input assembly formats, Tablet provides high-quality visualizations showing data in packed or stacked views, allowing instant access and navigation to any region of interest, and whole contig overviews and data summaries. Tablet is both multi-core aware and memory efficient, allowing it to handle assemblies containing millions of reads, even on a 32-bit desktop machine. Availability: Tablet is freely available for Microsoft Windows, Apple Mac OS X, Linux and Solaris. Fully bundled installers can be downloaded from http://bioinf.scri.ac.uk/tablet in 32- and 64-bit versions. Contact: tablet@scri.ac.uk PMID:19965881

  7. Extrasolar binary planets. I. Formation by tidal capture during planet-planet scattering

    International Nuclear Information System (INIS)

    Ochiai, H.; Nagasawa, M.; Ida, S.

    2014-01-01

    We have investigated (1) the formation of gravitationally bounded pairs of gas-giant planets (which we call 'binary planets') from capturing each other through planet-planet dynamical tide during their close encounters and (2) the subsequent long-term orbital evolution due to planet-planet and planet-star quasi-static tides. For the initial evolution in phase 1, we carried out N-body simulations of the systems consisting of three Jupiter-mass planets taking into account the dynamical tide. The formation rate of the binary planets is as much as 10% of the systems that undergo orbital crossing, and this fraction is almost independent of the initial stellarcentric semimajor axes of the planets, while ejection and merging rates sensitively depend on the semimajor axes. As a result of circularization by the planet-planet dynamical tide, typical binary separations are a few times the sum of the physical radii of the planets. After the orbital circularization, the evolution of the binary system is governed by long-term quasi-static tide. We analytically calculated the quasi-static tidal evolution in phase 2. The binary planets first enter the spin-orbit synchronous state by the planet-planet tide. The planet-star tide removes angular momentum of the binary motion, eventually resulting in a collision between the planets. However, we found that the binary planets survive the tidal decay for the main-sequence lifetime of solar-type stars (∼10 Gyr), if the binary planets are beyond ∼0.3 AU from the central stars. These results suggest that the binary planets can be detected by transit observations at ≳ 0.3 AU.

  8. Modeling the video distribution link in the Next Generation Optical Access Networks

    DEFF Research Database (Denmark)

    Amaya, F.; Cárdenas, A.; Tafur Monroy, Idelfonso

    2011-01-01

    In this work we present a model for the design and optimization of the video distribution link in the next generation optical access network. We analyze the video distribution performance in a SCM-WDM link, including the noise, the distortion and the fiber optic nonlinearities. Additionally, we...... consider in the model the effect of distributed Raman amplification, used to extent the capacity and the reach of the optical link. In the model, we use the nonlinear Schrödinger equation with the purpose to obtain capacity limitations and design constrains of the next generation optical access networks....

  9. NEXT GENERATION TURBINE SYSTEM STUDY

    Energy Technology Data Exchange (ETDEWEB)

    Frank Macri

    2002-02-28

    Rolls-Royce has completed a preliminary design and marketing study under a Department of Energy (DOE) cost shared contract (DE-AC26-00NT40852) to analyze the feasibility of developing a clean, high efficiency, and flexible Next Generation Turbine (NGT) system to meet the power generation market needs of the year 2007 and beyond. Rolls-Royce evaluated the full range of its most advanced commercial aerospace and aeroderivative engines alongside the special technologies necessary to achieve the aggressive efficiency, performance, emissions, economic, and flexibility targets desired by the DOE. Heavy emphasis was placed on evaluating the technical risks and the economic viability of various concept and technology options available. This was necessary to ensure the resulting advanced NGT system would provide extensive public benefits and significant customer benefits without introducing unacceptable levels of technical and operational risk that would impair the market acceptance of the resulting product. Two advanced cycle configurations were identified as offering significant advantages over current combined cycle products available in the market. In addition, balance of plant (BOP) technologies, as well as capabilities to improve the reliability, availability, and maintainability (RAM) of industrial gas turbine engines, have been identified. A customer focused survey and economic analysis of a proposed Rolls-Royce NGT product configuration was also accomplished as a part of this research study. The proposed Rolls-Royce NGT solution could offer customers clean, flexible power generation systems with very high efficiencies, similar to combined cycle plants, but at a much lower specific cost, similar to those of simple cycle plants.

  10. Promising Practices: Building the Next Generation of School Leaders

    Science.gov (United States)

    Bryant, Jennifer Edic; Escalante, Karen; Selva, Ashley

    2017-01-01

    This study applies transformational leadership theory practices to examine the purposeful ways in which principals work to build the next generation of teacher leaders in response to the shortage of K-12 principals. Given the impact principals have on student development and the shortage of those applying for the principalship, the purpose of this…

  11. MacSyFinder: a program to mine genomes for molecular systems with an application to CRISPR-Cas systems.

    Directory of Open Access Journals (Sweden)

    Sophie S Abby

    Full Text Available Biologists often wish to use their knowledge on a few experimental models of a given molecular system to identify homologs in genomic data. We developed a generic tool for this purpose.Macromolecular System Finder (MacSyFinder provides a flexible framework to model the properties of molecular systems (cellular machinery or pathway including their components, evolutionary associations with other systems and genetic architecture. Modelled features also include functional analogs, and the multiple uses of a same component by different systems. Models are used to search for molecular systems in complete genomes or in unstructured data like metagenomes. The components of the systems are searched by sequence similarity using Hidden Markov model (HMM protein profiles. The assignment of hits to a given system is decided based on compliance with the content and organization of the system model. A graphical interface, MacSyView, facilitates the analysis of the results by showing overviews of component content and genomic context. To exemplify the use of MacSyFinder we built models to detect and class CRISPR-Cas systems following a previously established classification. We show that MacSyFinder allows to easily define an accurate "Cas-finder" using publicly available protein profiles.MacSyFinder is a standalone application implemented in Python. It requires Python 2.7, Hmmer and makeblastdb (version 2.2.28 or higher. It is freely available with its source code under a GPLv3 license at https://github.com/gem-pasteur/macsyfinder. It is compatible with all platforms supporting Python and Hmmer/makeblastdb. The "Cas-finder" (models and HMM profiles is distributed as a compressed tarball archive as Supporting Information.

  12. Safety reviews of next-generation light-water reactors

    International Nuclear Information System (INIS)

    Kudrick, J.A.; Wilson, J.N.

    1997-01-01

    The Nuclear Regulatory Commission (NRC) is reviewing three applications for design certification under its new licensing process. The U.S. Advanced Boiling Water Reactor (ABWR) and System 80+ designs have received final design approvals. The AP600 design review is continuing. The goals of design certification are to achieve early resolution of safety issues and to provide a more stable and predictable licensing process. NRC also reviewed the Utility Requirements Document (URD) of the Electric Power Research Institute (EPRI) and determined that its guidance does not conflict with NRC requirements. This review led to the identification and resolution of many generic safety issues. The NRC determined that next-generation reactor designs should achieve a higher level of safety for selected technical and severe accident issues. Accordingly, NRC developed new review standards for these designs based on (1) operating experience, including the accident at Three Mile Island, Unit 2; (2) the results of probabilistic risk assessments of current and next-generation reactor designs; (3) early efforts on severe accident rulemaking; and (4) research conducted to address previously identified generic safety issues. The additional standards were used during the individual design reviews and the resolutions are documented in the design certification rules. 12 refs

  13. Standardization and quality management in next-generation sequencing.

    Science.gov (United States)

    Endrullat, Christoph; Glökler, Jörn; Franke, Philipp; Frohme, Marcus

    2016-09-01

    DNA sequencing continues to evolve quickly even after > 30 years. Many new platforms suddenly appeared and former established systems have vanished in almost the same manner. Since establishment of next-generation sequencing devices, this progress gains momentum due to the continually growing demand for higher throughput, lower costs and better quality of data. In consequence of this rapid development, standardized procedures and data formats as well as comprehensive quality management considerations are still scarce. Here, we listed and summarized current standardization efforts and quality management initiatives from companies, organizations and societies in form of published studies and ongoing projects. These comprise on the one hand quality documentation issues like technical notes, accreditation checklists and guidelines for validation of sequencing workflows. On the other hand, general standard proposals and quality metrics are developed and applied to the sequencing workflow steps with the main focus on upstream processes. Finally, certain standard developments for downstream pipeline data handling, processing and storage are discussed in brief. These standardization approaches represent a first basis for continuing work in order to prospectively implement next-generation sequencing in important areas such as clinical diagnostics, where reliable results and fast processing is crucial. Additionally, these efforts will exert a decisive influence on traceability and reproducibility of sequence data.

  14. Towards Next Generation Internet Management:CNGI-CERNET2EXPERIENCES

    Institute of Scientific and Technical Information of China (English)

    Jia-Hai Yang; Hui Zhang; Jin-Xiang Zhang; Chang-Qing An

    2009-01-01

    Manageability is an important feature of next generation Internet; management and monitoring of IPv6-based networks are proving a big challenge. While leveraging current IPv4-based SNMP management scheme to IPv6 networks'management need is necessary, it is more urgent to coin a new network management architecture to accommodate the scalability and extensibility requirements of next generation Internet management. The paper proposes a novel network management architecture, IMN (Internet Management Network), which creates an overlay network of management nodes.While each management node can perform management tasks autonomously and independently, it can finish more sophis-ticated management tasks by collaboratively invoking management operations or sharing information provided by other management nodes. P2P-based communication services are introduced in IMN to enable such collaboration. The paper presents a prototyping implementation based on the Web service related technology, as well as some of the key technologies,especially solutions to those issues arising from the management practice of CERNET2. Experiences of deployment of CERNET2 operation and lessons learned from the management practice are discussed.

  15. Convection and magnetic field generation in the interior of planets (August Love Medal Lecture)

    Science.gov (United States)

    Christensen, U. R.

    2009-04-01

    Thermal convection driven by internal energy plays a role of paramount importance in planetary bodies. Its numerical modeling has been an essential tool for understanding how the internal engine of a planet works. Solid state convection in the silicate or icy mantles is the cause of endogenic tectonic activity, volcanism and, in the case of Earth, of plate motion. It also regulates the energy budget of the entire planet, including that of its core, and controls the presence or absence of a dynamo. The complex rheology of solid minerals, effects of phase transitions, and chemical heterogeneity are important issues in mantle convection. Examples discussed here are the convection pattern in Mars and the complex morphology of subducted slabs that are observed by seismic tomography in the Earth's mantle. Internally driven convection in the deep gas envelopes of the giant planets is possibly the cause for the strong jet streams at the surfaces that give rise to their banded appearance. Modeling of the magnetohydrodynamic flow in the conducting liquid core of the Earth has been remarkably successful in reproducing the primary properties of the geomagnetic field. As an examplefor attempts to explain also secondary properties, I will discuss dynamo models that account for the thermal coupling to the mantle. The understanding of the somewhat enigmatic magnetic fields of some other planets is less advanced. Here I will show that dynamos that operate below a stable conducting layer in the upper part of the planetary core can explain the unusual magnetic field properties of Mercury and Saturn. The question what determines the strength of a dynamo-generated magnetic field has been a matter of debate. From a large set of numerical dynamo simulations that cover a fair range of control parameters, we find a rule that relates magnetic field strength to the part of the energy flux that is thermodynamically available to be transformed into other forms of energy. This rules predicts

  16. A simplified Track Assembler I/O for the Muon Trigger Track Finder

    CERN Document Server

    Dallavalle, Gaetano-Marco; Genchev, Vladimir; Grandi, Claudio; Neumeister, Norbert; Porth, Paul; Rohringer, Herbert

    1998-01-01

    One of the architectural concerns in the present design of the Muon Trigger Track Finder ( MTTF) is the large number of inputs to the Track Assembler ( TA). In the TA block, input track segment pairs from many Extrapolation Units ( EU) are associated into tracks. The relative contribution of these inputs to the assembled tracks is studied with simulated track patterns for low and high pt muons over the entire eta, phi acceptance of the CMS barrel. A pruning of the EUs is proposed which does not alter the performance of the Track Finder and minimizes the interconnections between azimuthal wedges.

  17. Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila

    Directory of Open Access Journals (Sweden)

    Patrice D. Cani

    2017-09-01

    Full Text Available Metabolic disorders associated with obesity and cardiometabolic disorders are worldwide epidemic. Among the different environmental factors, the gut microbiota is now considered as a key player interfering with energy metabolism and host susceptibility to several non-communicable diseases. Among the next-generation beneficial microbes that have been identified, Akkermansia muciniphila is a promising candidate. Indeed, A. muciniphila is inversely associated with obesity, diabetes, cardiometabolic diseases and low-grade inflammation. Besides the numerous correlations observed, a large body of evidence has demonstrated the causal beneficial impact of this bacterium in a variety of preclinical models. Translating these exciting observations to human would be the next logic step and it now appears that several obstacles that would prevent the use of A. muciniphila administration in humans have been overcome. Moreover, several lines of evidence indicate that pasteurization of A. muciniphila not only increases its stability but more importantly increases its efficacy. This strongly positions A. muciniphila in the forefront of next-generation candidates for developing novel food or pharma supplements with beneficial effects. Finally, a specific protein present on the outer membrane of A. muciniphila, termed Amuc_1100, could be strong candidate for future drug development. In conclusion, as plants and its related knowledge, known as pharmacognosy, have been the source for designing drugs over the last century, we propose that microbes and microbiomegnosy, or knowledge of our gut microbiome, can become a novel source of future therapies.

  18. Next-Generation Ultra-Compact Stowage/Lightweight Solar Array System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Deployable Space Systems, Inc. (DSS) has developed a next-generation high performance solar array system that has game-changing performance metrics in terms of...

  19. The Dynamic Pricing of Next Generation Consumer Durables

    OpenAIRE

    Barry L. Bayus

    1992-01-01

    Learning curve effects, aspects of consumer demand models (e.g., reservation price distributions, intertemporal utility maximizing behavior), and competitive activity are reasons which have been offered to explain why prices of new durables decline over time. This paper presents an alternative rationale based on the buying behavior for products with overlapping replacement cycles (i.e., next generation products). A model for consumer sales of a new durable is developed by incorporating the re...

  20. On reactor type comparisons for the next generation of reactors

    International Nuclear Information System (INIS)

    Alesso, H.P.; Majumdar, K.C.

    1991-01-01

    In this paper, we present a broad comparison of studies for a selected set of parameters for different nuclear reactor types including the next generation. This serves as an overview of key parameters which provide a semi-quantitative decision basis for selecting nuclear strategies. Out of a number of advanced reactor designs of the LWR type, gas cooled type, and FBR type, currently on the drawing board, the Advanced Light Water Reactors (ALWR) seem to have some edge over other types of the next generation of reactors for the near-term application. This is based on a number of attributes related to the benefit of the vast operating experience with LWRs coupled with an estimated low risk profile, economics of scale, degree of utilization of passive systems, simplification in the plant design and layout, modular fabrication and manufacturing. 32 refs., 1 fig., 3 tabs

  1. R&D, Marketing, and the Success of Next-Generation Products

    OpenAIRE

    Elie Ofek; Miklos Sarvary

    2003-01-01

    This paper studies dynamic competition in markets characterized by the introduction of technologically advanced next-generation products. Firms invest in new product effort in an attempt to attain industry leadership, thus securing high profits and benefiting from advantages relevant for the success of future product generations. The analysis reveals that when the current leader possesses higher research and development (R&D) competence, it tends to investin R&D than rivals and to retain its ...

  2. Next-Generation Sequencing in Neuropathologic Diagnosis of Infections of the Nervous System (Open Access)

    Science.gov (United States)

    2016-06-13

    nervous system ABSTRACT Objective: To determine the feasibility of next-generation sequencing (NGS) microbiome ap- proaches in the diagnosis of infectious...V, van Doorn HR, Nghia HD, et al. Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections...Kumar, et al. system Next-generation sequencing in neuropathologic diagnosis of infections of the nervous This information is current as of June 13

  3. Conceptual design of next generation MTR

    Energy Technology Data Exchange (ETDEWEB)

    Nagata, Hiroshi; Yamaura, Takayuki; Naka, Michihiro; Kawamata, Kazuo; Izumo, Hironobu; Hori, Naohiko; Nagao, Yoshiharu; Kusunoki, Tsuyoshi; Kaminaga, Masanori; Komori, Yoshihiro; Suzuki, Masahide; Kawamura, Hiroshi [Japan Atomic Energy Agency, Oarai Research and Development Center, Oarai, Ibaraki (Japan); Mine, M [Hitachi-GE Nuclear Energy, Ltd., Hitachi, Ibaraki (Japan); Yamazaki, S [Kawasaki Heavy Industries, Ltd., Kobe, Hyogo (Japan); Ishikawa, S [NGK Insulators, Ltd., Nagoya, Aichi (Japan); Miura, K [Sukegawa Electric Co., Ltd., Takahagi, Ibaraki (Japan); Nakashima, S [Fuji Electric Co., Ltd., Tokyo (Japan); Yamaguchi, K [Chiyoda Technol Corp., Tokyo (Japan)

    2012-03-15

    Conceptual design of the high-performance and low-cost next generation materials testing reactor (MTR) which will be expected to construct in the nuclear power plant introduction countries, started from 2010 in JAEA and nuclear-related companies in Japan. The aims of this conceptual design are to achieve highly safe reactor, economical design, high availability factor and advanced irradiation utilization. One of the basic reactor concept was determined as swimming pool type, thermal power of 10MW and water cooled and moderated reactor with plate type fuel element same as the JMTR. It is expected that the research reactors are used for human resource development, progress of the science and technology, expansion of industry use, lifetime extension of LWRs and so on. (author)

  4. WEAVE: the next generation wide-field spectroscopy facility for the William Herschel Telescope : The next generation wide-field spectroscopy facility for the William Herschel Telescope

    NARCIS (Netherlands)

    Dalton, Gavin; Trager, Scott C.; Abrams, Don Carlos; Carter, David; Bonifacio, Piercarlo; Aguerri, J. Alfonso L.; MacIntosh, Mike; Evans, Chris; Lewis, Ian; Navarro, Ramon; Agocs, Tibor; Dee, Kevin; Rousset, Sophie; Tosh, Ian; Middleton, Kevin; Pragt, Johannes; Terrett, David; Brock, Matthew; Benn, Chris; Verheijen, Marc; Cano Infantes, Diego; Bevil, Craige; Steele, Iain; Mottram, Chris; Bates, Stuart; Gribbin, Francis J.; Rey, Jürg; Rodriguez, Luis Fernando; Delgado, Jose Miguel; Guinouard, Isabelle; Walton, Nic; Irwin, Michael J.; Jagourel, Pascal; Stuik, Remko; Gerlofsma, Gerrit; Roelfsma, Ronald; Skillen, Ian; Ridings, Andy; Balcells, Marc; Daban, Jean-Baptiste; Gouvret, Carole; Venema, Lars; Girard, Paul

    We present the preliminary design of the WEAVE next generation spectroscopy facility for the William Herschel Telescope (WHT), principally targeting optical ground-based follow up of upcoming ground-based (LOFAR) and spacebased (Gaia) surveys. WEAVE is a multi-object and multi-IFU facility utilizing

  5. New long-range speed record with next-generation internet

    CERN Multimedia

    2003-01-01

    "Scientists at CERN and the California Institute of Technology have set a new Internet2 land speed record using the next-generation Internet protocol IPv6. The team sustained a single stream Transfer Control Protocol (TCP) rate of 983 megabits per second for more than one hour between CERN and Chicago, a distance of more than 7,000 kilometres" (1 page).

  6. The construction of next-generation matrices for compartmental epidemic models

    NARCIS (Netherlands)

    Diekmann, O.|info:eu-repo/dai/nl/071896856; Heesterbeek, J.A.P.|info:eu-repo/dai/nl/073321427; Roberts, M.G.

    2010-01-01

    The basic reproduction number R0 is arguably the most important quantity in infectious disease epidemiology. The next-generation matrix (NGM) is the natural basis for the definition and calculation of R0 where finitely many different categories of individuals are recognized. We clear up confusion

  7. Impact of ectopic pregnancy for reproductive prognosis in next generation

    DEFF Research Database (Denmark)

    Kårhus, Line Lund; Egerup, Pia; Skovlund, Charlotte Wessel

    2014-01-01

    The impact of an ectopic pregnancy in the next generation is unknown. Our aim was to compare reproductive outcomes in daughters of women with and without ectopic pregnancy. Designed as a historical prospective controlled cohort study with data collected in four Danish registries from 1977-2009, w...

  8. Statistical analysis of next generation sequencing data

    CERN Document Server

    Nettleton, Dan

    2014-01-01

    Next Generation Sequencing (NGS) is the latest high throughput technology to revolutionize genomic research. NGS generates massive genomic datasets that play a key role in the big data phenomenon that surrounds us today. To extract signals from high-dimensional NGS data and make valid statistical inferences and predictions, novel data analytic and statistical techniques are needed. This book contains 20 chapters written by prominent statisticians working with NGS data. The topics range from basic preprocessing and analysis with NGS data to more complex genomic applications such as copy number variation and isoform expression detection. Research statisticians who want to learn about this growing and exciting area will find this book useful. In addition, many chapters from this book could be included in graduate-level classes in statistical bioinformatics for training future biostatisticians who will be expected to deal with genomic data in basic biomedical research, genomic clinical trials and personalized med...

  9. THREE PLANETS ORBITING WOLF 1061

    Energy Technology Data Exchange (ETDEWEB)

    Wright, D. J.; Wittenmyer, R. A.; Tinney, C. G.; Bentley, J. S.; Zhao, Jinglin, E-mail: duncan.wright@unsw.edu.au [Department of Astronomy and Australian Centre for Astrobiology, School of Physics, University of New South Wales, NSW 2052 (Australia)

    2016-02-01

    We use archival HARPS spectra to detect three planets orbiting the M3 dwarf Wolf 1061 (GJ 628). We detect a 1.36 M{sub ⊕} minimum-mass planet with an orbital period P = 4.888 days (Wolf 1061b), a 4.25 M{sub ⊕} minimum-mass planet with orbital period P = 17.867 days (Wolf 1061c), and a likely 5.21 M{sub ⊕} minimum-mass planet with orbital period P = 67.274 days (Wolf 1061d). All of the planets are of sufficiently low mass that they may be rocky in nature. The 17.867 day planet falls within the habitable zone for Wolf 1061 and the 67.274 day planet falls just outside the outer boundary of the habitable zone. There are no signs of activity observed in the bisector spans, cross-correlation FWHMs, calcium H and K indices, NaD indices, or Hα indices near the planetary periods. We use custom methods to generate a cross-correlation template tailored to the star. The resulting velocities do not suffer the strong annual variation observed in the HARPS DRS velocities. This differential technique should deliver better exploitation of the archival HARPS data for the detection of planets at extremely low amplitudes.

  10. PLANET-PLANET SCATTERING IN PLANETESIMAL DISKS

    International Nuclear Information System (INIS)

    Raymond, Sean N.; Armitage, Philip J.; Gorelick, Noel

    2009-01-01

    We study the final architecture of planetary systems that evolve under the combined effects of planet-planet and planetesimal scattering. Using N-body simulations we investigate the dynamics of marginally unstable systems of gas and ice giants both in isolation and when the planets form interior to a planetesimal belt. The unstable isolated systems evolve under planet-planet scattering to yield an eccentricity distribution that matches that observed for extrasolar planets. When planetesimals are included the outcome depends upon the total mass of the planets. For M tot ∼> 1 M J the final eccentricity distribution remains broad, whereas for M tot ∼ J a combination of divergent orbital evolution and recircularization of scattered planets results in a preponderance of nearly circular final orbits. We also study the fate of marginally stable multiple planet systems in the presence of planetesimal disks, and find that for high planet masses the majority of such systems evolve into resonance. A significant fraction leads to resonant chains that are planetary analogs of Jupiter's Galilean satellites. We predict that a transition from eccentric to near-circular orbits will be observed once extrasolar planet surveys detect sub-Jovian mass planets at orbital radii of a ≅ 5-10 AU.

  11. INL Human Resource Development and the Next-Generation Safeguards Initiative

    Energy Technology Data Exchange (ETDEWEB)

    Gouveia, Fernando; Metcalf, Richard Royce Madison

    2010-07-01

    It is the stated goal of the Next Generation Safeguards Initiative (NGSI) to promote the development of a strengthened nuclear safeguards base, one with the potential to advance the secure and peaceful implementation of nuclear energy world-wide. To meet this goal, the initiative, among other things, has sought to develop a revitalized effort to ensure the continued availability of next generation safeguards professionals. Accordingly, this paper serves to outline the human capital building strategies taken by Idaho National Laboratory (INL) in line with the NGSI. Various components are presented in detail, including INL’s efforts directed at university outreach, in particular the laboratory’s summer internship program, along with the development of various innovative training programs and long-term oriented strategies for student professional development. Special highlights include a video training series, developed by INL in cooperation with LLNL and other laboratories, which sought to expose students and entry-level professionals to the concept and practice of international nuclear safeguards.

  12. Next Generation Workload Management and Analysis System for Big Data

    Energy Technology Data Exchange (ETDEWEB)

    De, Kaushik [Univ. of Texas, Arlington, TX (United States)

    2017-04-24

    We report on the activities and accomplishments of a four-year project (a three-year grant followed by a one-year no cost extension) to develop a next generation workload management system for Big Data. The new system is based on the highly successful PanDA software developed for High Energy Physics (HEP) in 2005. PanDA is used by the ATLAS experiment at the Large Hadron Collider (LHC), and the AMS experiment at the space station. The program of work described here was carried out by two teams of developers working collaboratively at Brookhaven National Laboratory (BNL) and the University of Texas at Arlington (UTA). These teams worked closely with the original PanDA team – for the sake of clarity the work of the next generation team will be referred to as the BigPanDA project. Their work has led to the adoption of BigPanDA by the COMPASS experiment at CERN, and many other experiments and science projects worldwide.

  13. The Fate of Unstable Circumbinary Planets

    Science.gov (United States)

    Kohler, Susanna

    2016-03-01

    What happens to Tattooine-like planets that are instead in unstable orbits around their binary star system? A new study examines whether such planets will crash into a host star, get ejected from the system, or become captured into orbit around one of their hosts.Orbit Around a DuoAt this point we have unambiguously detected multiple circumbinary planets, raising questions about these planets formation and evolution. Current models suggest that it is unlikely that circumbinary planets would be able to form in the perturbed environment close their host stars. Instead, its thought that the planets formed at a distance and then migrated inwards.One danger such planets face when migrating is encountering ranges of radii where their orbits become unstable. Two scientists at the University of Chicago, Adam Sutherland and Daniel Fabrycky, have studied what happens when circumbinary planets migrate into such a region and develop unstable orbits.Producing Rogue PlanetsTime for planets to either be ejected or collide with one of the two stars, as a function of the planets starting distance (in AU) from the binary barycenter. Colors represent different planetary eccentricities. [Sutherland Fabrycky 2016]Sutherland and Fabrycky used N-body simulations to determine the fates of planets orbiting around a star system consisting of two stars a primary like our Sun and a secondary roughly a tenth of its size that are separated by 1 AU.The authors find that the most common fate for a circumbinary planet with an unstable orbit is ejection from the system; over 80% of unstable planets were ejected. This has interesting implications: if the formation of circumbinary planets is common, this mechanism could be filling the Milky Way with a population of free-floating, rogue planets that no longer are associated with their host star.The next most common outcome for unstable planets is collision with one of their host stars (most often the secondary), resulting inaccretion of the planet

  14. Survival of extrasolar giant planet moons in planet-planet scattering

    Science.gov (United States)

    CIAN HONG, YU; Lunine, Jonathan; Nicholson, Phillip; Raymond, Sean

    2015-12-01

    Planet-planet scattering is the best candidate mechanism for explaining the eccentricity distribution of exoplanets. Here we study the survival and dynamics of exomoons under strong perturbations during giant planet scattering. During close encounters, planets and moons exchange orbital angular momentum and energy. The most common outcomes are the destruction of moons by ejection from the system, collision with the planets and the star, and scattering of moons onto perturbed but still planet-bound orbits. A small percentage of interesting moons can remain bound to ejected (free-floating) planets or be captured by a different planet. Moons' survival rate is correlated with planet observables such as mass, semi-major axis, eccentricity and inclination, as well as the close encounter distance and the number of close encounters. In addition, moons' survival rate and dynamical outcomes are predetermined by the moons' initial semi-major axes. The survival rate drops quickly as moons' distances increase, but simulations predict a good chance of survival for the Galilean moons. Moons with different dynamical outcomes occupy different regions of orbital parameter space, which may enable the study of moons' past evolution. Potential effects of planet obliquity evolution caused by close encounters on the satellites’ stability and dynamics will be reported, as well as detailed and systematic studies of individual close encounter events.

  15. Addressing Three Common Myths about the Next Generation Science Standards

    Science.gov (United States)

    Huff, Kenneth L.

    2016-01-01

    Although the "Next Generation Science Standards" (NGSS Lead States 2013) were released over two years ago, misconceptions about what they are--and are not--persist. The "NGSS" provide for consistent science education opportunities for all students--regardless of demographics--with a level of rigor expected in every location and…

  16. Compact 2100 nm laser diode module for next-generation DIRCM

    Science.gov (United States)

    Dvinelis, Edgaras; Greibus, Mindaugas; TrinkÅ«nas, Augustinas; NaujokaitÄ--, Greta; Vizbaras, Augustinas; Vizbaras, Dominykas; Vizbaras, Kristijonas

    2017-10-01

    Compact high-power 2100 nm laser diode module for next-generation directional infrared countermeasure (DIRCM) systems is presented. Next-generation DIRCM systems require compact, light-weight and robust laser modules which could provide intense IR light emission capable of disrupting the tracking sensor of heat-seeking missile. Currently used solid-state and fiber laser solutions for mid-IR band are bulky and heavy making them difficult to implement in smaller form-factor DIRCM systems. Recent development of GaSb laser diode technology greatly improved optical output powers and efficiencies of laser diodes working in 1900 - 2450 nm band [1] while also maintaining very attractive size, weight, power consumption and cost characteristics. 2100 nm laser diode module presented in this work performance is based on high-efficiency broad emitting area GaSb laser diode technology. Each laser diode emitter is able to provide 1 W of CW output optical power with working point efficiency up to 20% at temperature of 20 °C. For output beam collimation custom designed fast-axis collimator and slow-axis collimator lenses were used. These lenses were actively aligned and attached using UV epoxy curing. Total 2 emitters stacked vertically were used in 2100 nm laser diode module. Final optical output power of the module goes up to 2 W at temperature of 20 °C. Total dimensions of the laser diode module are 35 x 25 x 16 mm (L x W x H) with a weight of 28 grams. Finally output beam is bore-sighted to mechanical axes of the module housing allowing for easy integration into next-generation DIRCM systems.

  17. Next-generation genome-scale models for metabolic engineering

    DEFF Research Database (Denmark)

    King, Zachary A.; Lloyd, Colton J.; Feist, Adam M.

    2015-01-01

    Constraint-based reconstruction and analysis (COBRA) methods have become widely used tools for metabolic engineering in both academic and industrial laboratories. By employing a genome-scale in silico representation of the metabolic network of a host organism, COBRA methods can be used to predict...... examples of applying COBRA methods to strain optimization are presented and discussed. Then, an outlook is provided on the next generation of COBRA models and the new types of predictions they will enable for systems metabolic engineering....

  18. Towards next-generation biodiversity assessment using DNA metabarcoding

    DEFF Research Database (Denmark)

    Taberlet, Pierre; Coissac, Eric; Pompanon, Francois

    2012-01-01

    Virtually all empirical ecological studies require species identification during data collection. DNA metabarcoding refers to the automated identification of multiple species from a single bulk sample containing entire organisms or from a single environmental sample containing degraded DNA (soil......, water, faeces, etc.). It can be implemented for both modern and ancient environmental samples. The availability of next-generation sequencing platforms and the ecologists need for high-throughput taxon identification have facilitated the emergence of DNA metabarcoding. The potential power of DNA...

  19. JVM: Java Visual Mapping tool for next generation sequencing read.

    Science.gov (United States)

    Yang, Ye; Liu, Juan

    2015-01-01

    We developed a program JVM (Java Visual Mapping) for mapping next generation sequencing read to reference sequence. The program is implemented in Java and is designed to deal with millions of short read generated by sequence alignment using the Illumina sequencing technology. It employs seed index strategy and octal encoding operations for sequence alignments. JVM is useful for DNA-Seq, RNA-Seq when dealing with single-end resequencing. JVM is a desktop application, which supports reads capacity from 1 MB to 10 GB.

  20. PROBABILISTIC MODEL OF LASER RANGE FINDER FOR THREE DIMENSIONAL GRID CELL IN CLOSE RANGE ENVIRONMENT

    Directory of Open Access Journals (Sweden)

    Hafiz b Iman

    2016-04-01

    Full Text Available The probabilistic model of a laser scanner presents an important aspect for simultaneous localization and map-building (SLAM. However, the characteristic of the beam of the laser range finder under extreme incident angles approaching 900 has not been thoroughly investigated. This research paper reports the characteristic of the density of the range value coming from a laser range finder under close range circumstances where the laser is imposed with a high incident angle. The laser was placed in a controlled environment consisting of walls at a close range and 1000 iteration of scans was collected. The assumption of normal density of the metrical data collapses when the beam traverses across sharp edges in this environment. The data collected also shows multimodal density at instances where the range has discontinuity. The standard deviation of the laser range finder is reported to average at 10.54 mm, with 0.96 of accuracy. This significance suggests that under extreme incident angles, a laser range finder reading behaves differently compared to normal distribution. The use of this information is crucial for SLAM activity in enclosed environments such as inside piping grid or other cluttered environments.KEYWORDS:   Hokuyo UTM-30LX; kernel density estimation; probabilistic model  

  1. Development of technology for next generation reactor - Research of evaluation technology for nuclear power plant -

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jong Kyun; Chang, Moon Heuy; Hwang, Yung Dong [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)] [and others

    1993-09-01

    For development of next generation reactor, a project for evaluation technology for nuclear power plant is performed. Evaluation technology is essential to next generation reactor for reactor safety and system analysis. For design concept, detailed evaluation technologies are studied as follows: evaluation of safety margin, evaluation of safety facilities, evaluation of measurement and control technology; man-machine interface. Especially for thermal efficiency, thermal properties and chemical composition of inconel 690 tube, instead of inconel 600 tube, are measured for steam generator. (Author).

  2. Next Generation Carbon-Nitrogen Dynamics Model

    Science.gov (United States)

    Xu, C.; Fisher, R. A.; Vrugt, J. A.; Wullschleger, S. D.; McDowell, N. G.

    2012-12-01

    Nitrogen is a key regulator of vegetation dynamics, soil carbon release, and terrestrial carbon cycles. Thus, to assess energy impacts on the global carbon cycle and future climates, it is critical that we have a mechanism-based and data-calibrated nitrogen model that simulates nitrogen limitation upon both above and belowground carbon dynamics. In this study, we developed a next generation nitrogen-carbon dynamic model within the NCAR Community Earth System Model (CESM). This next generation nitrogen-carbon dynamic model utilized 1) a mechanistic model of nitrogen limitation on photosynthesis with nitrogen trade-offs among light absorption, electron transport, carboxylation, respiration and storage; 2) an optimal leaf nitrogen model that links soil nitrogen availability and leaf nitrogen content; and 3) an ecosystem demography (ED) model that simulates the growth and light competition of tree cohorts and is currently coupled to CLM. Our three test cases with changes in CO2 concentration, growing temperature and radiation demonstrate the model's ability to predict the impact of altered environmental conditions on nitrogen allocations. Currently, we are testing the model against different datasets including soil fertilization and Free Air CO2 enrichment (FACE) experiments across different forest types. We expect that our calibrated model will considerably improve our understanding and predictability of vegetation-climate interactions.itrogen allocation model evaluations. The figure shows the scatter plots of predicted and measured Vc,max and Jmax scaled to 25 oC (i.e.,Vc,max25 and Jmax25) at elevated CO2 (570 ppm, test case one), reduced radiation in canopy (0.1-0.9 of the radiation at the top of canopy, test case two) and reduced growing temperature (15oC, test case three). The model is first calibrated using control data under ambient CO2 (370 ppm), radiation at the top of the canopy (621 μmol photon/m2/s), the normal growing temperature (30oC). The fitted model

  3. Nuclear Knowledge to the Next Generation

    International Nuclear Information System (INIS)

    Mazour, Thomas; Kossilov, Andrei

    2004-01-01

    The safe, reliable, and cost-effective operation of Nuclear Power Plants (NPPs) requires that personnel possess and maintain the requisite knowledge, skills, and attitudes to do their jobs properly. Such knowledge includes not only the technical competencies required by the nature of the technology and particular engineering designs, but also the softer competencies associated with effective management, communication and teamwork. Recent studies have shown that there has been a loss of corporate knowledge and memory. Both explicit knowledge and tacit knowledge must be passed on to the next generation of workers in the industry to ensure a quality workforce. New and different techniques may be required to ensure timely and effective knowledge retention and transfer. The IAEA prepared a report on this subject. The main conclusions from the report regarding strategies for managing the aging workforce are included. Also included are main conclusions from the report regarding the capture an d preservation of mission critical knowledge, and the effective transfer of this knowledge to the next generation of NPP personnel. The nuclear industry due to its need for well-documented procedures, specifications, design basis, safety analyses, etc., has a greater fraction of its mission critical knowledge as explicit knowledge than do many other industries. This facilitates the task of knowledge transfer. For older plants in particular, there may be a need for additional efforts to transfer tacit knowledge to explicit knowledge to support major strategic initiatives such as plant license extensions/renewals, periodic safety reviews, major plant upgrades, and plant specific control room simulator development. The challenge in disseminating explicit knowledge is to make employees aware that it is available and provide easy access in formats and forms that are usable. Tacit knowledge is more difficult to identify and disseminate. The challenge is to identify what can be converted to

  4. Using Digital Watermarking for Securing Next Generation Media Broadcasts

    Science.gov (United States)

    Birk, Dominik; Gaines, Seán

    The Internet presents a problem for the protection of intellectual property. Those who create content must be adequately compensated for the use of their works. Rights agencies who monitor the use of these works exist in many jurisdictions. In the traditional broadcast environment this monitoring is a difficult task. With Internet Protocol Television (IPTV) and Next Generation Networks (NGN) this situation is further complicated.

  5. High Throughput Line-of-Sight MIMO Systems for Next Generation Backhaul Applications

    Science.gov (United States)

    Song, Xiaohang; Cvetkovski, Darko; Hälsig, Tim; Rave, Wolfgang; Fettweis, Gerhard; Grass, Eckhard; Lankl, Berthold

    2017-09-01

    The evolution to ultra-dense next generation networks requires a massive increase in throughput and deployment flexibility. Therefore, novel wireless backhaul solutions that can support these demands are needed. In this work we present an approach for a millimeter wave line-of-sight MIMO backhaul design, targeting transmission rates in the order of 100 Gbit/s. We provide theoretical foundations for the concept showcasing its potential, which are confirmed through channel measurements. Furthermore, we provide insights into the system design with respect to antenna array setup, baseband processing, synchronization, and channel equalization. Implementation in a 60 GHz demonstrator setup proves the feasibility of the system concept for high throughput backhauling in next generation networks.

  6. Generation After Next Propulsor Research: Robust Design for Embedded Engine Systems

    Science.gov (United States)

    Arend, David J.; Tillman, Gregory; O'Brien, Walter F.

    2012-01-01

    The National Aeronautics and Space Administration, United Technologies Research Center and Virginia Polytechnic and State University have contracted to pursue multi-disciplinary research into boundary layer ingesting (BLI) propulsors for generation after next environmentally responsible subsonic fixed wing aircraft. This Robust Design for Embedded Engine Systems project first conducted a high-level vehicle system study based on a large commercial transport class hybrid wing body aircraft, which determined that a 3 to 5 percent reduction in fuel burn could be achieved over a 7,500 nanometer mission. Both pylon-mounted baseline and BLI propulsion systems were based on a low-pressure-ratio fan (1.35) in an ultra-high-bypass ratio engine (16), consistent with the next generation of advanced commercial turbofans. An optimized, coupled BLI inlet and fan system was subsequently designed to achieve performance targets identified in the system study. The resulting system possesses an inlet with total pressure losses less than 0.5%, and a fan stage with an efficiency debit of less than 1.5 percent relative to the pylon-mounted, clean-inflow baseline. The subject research project has identified tools and methodologies necessary for the design of next-generation, highly-airframe-integrated propulsion systems. These tools will be validated in future large-scale testing of the BLI inlet / fan system in NASA's 8 foot x 6 foot transonic wind tunnel. In addition, fan unsteady response to screen-generated total pressure distortion is being characterized experimentally in a JT15D engine test rig. These data will document engine sensitivities to distortion magnitude and spatial distribution, providing early insight into key physical processes that will control BLI propulsor design.

  7. Looking ahead to our next generation of nurse leaders: Generation X Nurse Managers.

    Science.gov (United States)

    Keys, Yolanda

    2014-01-01

    The present inquiry identifies elements of professional success, and personal and professional fulfilment as defined by Generation X Nurse Managers. Although work concerning Nurse Manager preparation has been documented, there is a paucity of research specific to the generation of nurses next in line to assume leadership roles. For the purposes of this study, a qualitative approach was used to develop insight regarding Generation X Nurse Managers and their perspectives on professional success, personal and professional fulfilment, and organisational environments that are conducive to loyalty and long-term professional commitment. Findings from this study reinforced those identified in the original study in that inflexible organisational cultures, a lack of opportunities for upward mobility, the need to be available at all times, feeling stereotyped or undervalued can all be barriers to members of Generation X perceptions of professional success and professional and personal fulfilment. Study findings suggest that Generation X Nurse Managers would benefit from initiatives focused on better preparation for the Nurse Manager role, openness to innovative scheduling alternatives and tailored support and feedback. © 2014 John Wiley & Sons Ltd.

  8. Fetal Kidney Anomalies: Next Generation Sequencing

    DEFF Research Database (Denmark)

    Rasmussen, Maria; Sunde, Lone; Nielsen, Marlene Louise

    Aim and Introduction Identification of abnormal kidneys in the fetus may lead to termination of the pregnancy and raises questions about the underlying cause and recurrence risk in future pregnancies. In this study, we investigate the effectiveness of targeted next generation sequencing in fetuses...... with prenatally detected kidney anomalies in order to uncover genetic explanations and assess recurrence risk. Also, we aim to study the relation between genetic findings and post mortem kidney histology. Methods The study comprises fetuses diagnosed prenatally with bilateral kidney anomalies that have undergone...... postmortem examination. The approximately 110 genes included in the targeted panel were chosen on the basis of their potential involvement in embryonic kidney development, cystic kidney disease, or the renin-angiotensin system. DNA was extracted from fetal tissue samples or cultured chorion villus cells...

  9. Leveraging the Thousands of Known Planets to Inform TESS Follow-Up

    Science.gov (United States)

    Ballard, Sarah

    2017-10-01

    The Solar System furnishes our most familiar planetary architecture: many planets, orbiting nearly coplanar to one another. However, a typical system of planets in the Milky Way orbits a much smaller M dwarf star, and these stars furnish a different blueprint in key ways than the conditions that nourished evolution of life on Earth. With ensemble studies of hundreds-to-thousands of exoplanets, I will describe the emerging links between planet formation from disks, orbital dynamics of planets, and the content and observability of planetary atmospheres. These quantities can be tied to observables even in discovery light curves, to enable judicious selection of follow-up targets from the ground and from space. After TESS exoplanet discoveries start in earnest, the studies of individual planets with large, space-based platforms comprise the clear next step toward understanding the hospitability of the Milky Way to life. Our success hinges upon leveraging the many thousands of planet discoveries in hand to determine how to use these precious and limited resources.

  10. Next Generation Nuclear Plant System Requirements Manual

    International Nuclear Information System (INIS)

    Not Listed

    2008-01-01

    System Requirements Manual for the NGNP Project. The Energy Policy Act of 2005 (H.R. 6; EPAct), which was signed into law by President George W. Bush in August 2005, required the Secretary of the U.S. Department of Energy (DOE) to establish a project to be known as the Next Generation Nuclear Plant (NGNP) Project. According to the EPAct, the NGNP Project shall consist of the research, development, design, construction, and operation of a prototype plant (to be referred to herein as the NGNP) that (1) includes a nuclear reactor based on the research and development (R and D) activities supported by the Generation IV Nuclear Energy Systems initiative, and (2) shall be used to generate electricity, to produce hydrogen, or to both generate electricity and produce hydrogen. The NGNP Project supports both the national need to develop safe, clean, economical nuclear energy and the Nuclear Hydrogen Initiative (NHI), which has the goal of establishing greenhouse-gas-free technologies for the production of hydrogen. The DOE has selected the helium-cooled High Temperature Gas-Cooled Reactor (HTGR) as the reactor concept to be used for the NGNP because it is the only near-term Generation IV concept that has the capability to provide process heat at high-enough temperatures for highly efficient production of hydrogen. The EPAct also names the Idaho National Laboratory (INL), the DOE's lead national laboratory for nuclear energy research, as the site for the prototype NGNP

  11. NextGEOSS: The Next Generation Data Hub For Earth Observations

    Science.gov (United States)

    Lilja Bye, Bente; De Lathouwer, Bart; Catarino, Nuno; Concalves, Pedro; Trijssenaar, Nicky; Grosso, Nuno; Meyer-Arnek, Julian; Goor, Erwin

    2017-04-01

    The Group on Earth observation embarked on the next 10 year phase with an ambition to streamline and further develop its achievements in building the Global Earth Observing System of Systems (GEOSS). The NextGEOSS project evolves the European vision of GEOSS data exploitation for innovation and business, relying on the three main pillars of engaging communities, delivering technological developments and advocating the use of GEOSS, in order to support the creation and deployment of Earth observation based innovative research activities and commercial services. In this presentation we will present the NextGEOSS concept, a concept that revolves around providing the data and resources to the users communities, together with Cloud resources, seamlessly connected to provide an integrated ecosystem for supporting applications. A central component of NextGEOSS is the strong emphasis put on engaging the communities of providers and users, and bridging the space in between.

  12. Super- and Transcritical Fluid Expansions for Next-Generation Energy Conversion Systems

    NARCIS (Netherlands)

    Harinck, J.

    2010-01-01

    The next generation of thermodynamic power cycles offers great potential as the conceptual basis for sustainable energy converters. Examples are the supercritical and superheated Organic Rankine cycle, the transcritical condensation cycle, the supercritical Brayton cycle, the Organic Stirling cycle

  13. Energy Efficient Glass Melting - The Next Generation Melter

    Energy Technology Data Exchange (ETDEWEB)

    David Rue

    2008-03-01

    The objective of this project is to demonstrate a high intensity glass melter, based on the submerged combustion melting technology. This melter will serve as the melting and homogenization section of a segmented, lower-capital cost, energy-efficient Next Generation Glass Melting System (NGMS). After this project, the melter will be ready to move toward commercial trials for some glasses needing little refining (fiberglass, etc.). For other glasses, a second project Phase or glass industry research is anticipated to develop the fining stage of the NGMS process.

  14. MiSeq: A Next Generation Sequencing Platform for Genomic Analysis.

    Science.gov (United States)

    Ravi, Rupesh Kanchi; Walton, Kendra; Khosroheidari, Mahdieh

    2018-01-01

    MiSeq, Illumina's integrated next generation sequencing instrument, uses reversible-terminator sequencing-by-synthesis technology to provide end-to-end sequencing solutions. The MiSeq instrument is one of the smallest benchtop sequencers that can perform onboard cluster generation, amplification, genomic DNA sequencing, and data analysis, including base calling, alignment and variant calling, in a single run. It performs both single- and paired-end runs with adjustable read lengths from 1 × 36 base pairs to 2 × 300 base pairs. A single run can produce output data of up to 15 Gb in as little as 4 h of runtime and can output up to 25 M single reads and 50 M paired-end reads. Thus, MiSeq provides an ideal platform for rapid turnaround time. MiSeq is also a cost-effective tool for various analyses focused on targeted gene sequencing (amplicon sequencing and target enrichment), metagenomics, and gene expression studies. For these reasons, MiSeq has become one of the most widely used next generation sequencing platforms. Here, we provide a protocol to prepare libraries for sequencing using the MiSeq instrument and basic guidelines for analysis of output data from the MiSeq sequencing run.

  15. Answers to Teachers' Questions about the Next Generation Science Standards

    Science.gov (United States)

    Workosky, Cindy; Willard, Ted

    2015-01-01

    K-12 teachers of science have been digging into the "Next Generation Science Standards" ("NGSS") (NGSS Lead States 2013) to begin creating plans and processes for translating them for classroom instruction. As teachers learn about the NGSS, they have asked about the general structure of the standards document and how to read…

  16. The Next Generation of Science Standards: Implications for Biology Education

    Science.gov (United States)

    Bybee, Rodger W.

    2012-01-01

    The release of A Framework for K-12 Science Education: Practices, Crosscutting Concepts, and Core Ideas (NRC, 2012) provides the basis for the next generation of science standards. This article first describes that foundation for the life sciences; it then presents a draft standard for natural selection and evolution. Finally, there is a…

  17. How does the Earth system generate and maintain thermodynamic disequilibrium and what does it imply for the future of the planet?

    Science.gov (United States)

    Kleidon, Axel

    2012-01-01

    The Earth's chemical composition far from chemical equilibrium is unique in our Solar System, and this uniqueness has been attributed to the presence of widespread life on the planet. Here, I show how this notion can be quantified using non-equilibrium thermodynamics. Generating and maintaining disequilibrium in a thermodynamic variable requires the extraction of power from another thermodynamic gradient, and the second law of thermodynamics imposes fundamental limits on how much power can be extracted. With this approach and associated limits, I show that the ability of abiotic processes to generate geochemical free energy that can be used to transform the surface–atmosphere environment is strongly limited to less than 1 TW. Photosynthetic life generates more than 200 TW by performing photochemistry, thereby substantiating the notion that a geochemical composition far from equilibrium can be a sign for strong biotic activity. Present-day free energy consumption by human activity in the form of industrial activity and human appropriated net primary productivity is of the order of 50 TW and therefore constitutes a considerable term in the free energy budget of the planet. When aiming to predict the future of the planet, we first note that since global changes are closely related to this consumption of free energy, and the demands for free energy by human activity are anticipated to increase substantially in the future, the central question in the context of predicting future global change is then how human free energy demands can increase sustainably without negatively impacting the ability of the Earth system to generate free energy. This question could be evaluated with climate models, and the potential deficiencies in these models to adequately represent the thermodynamics of the Earth system are discussed. Then, I illustrate the implications of this thermodynamic perspective by discussing the forms of renewable energy and planetary engineering that would

  18. How does the Earth system generate and maintain thermodynamic disequilibrium and what does it imply for the future of the planet?

    Science.gov (United States)

    Kleidon, Axel

    2012-03-13

    The Earth's chemical composition far from chemical equilibrium is unique in our Solar System, and this uniqueness has been attributed to the presence of widespread life on the planet. Here, I show how this notion can be quantified using non-equilibrium thermodynamics. Generating and maintaining disequilibrium in a thermodynamic variable requires the extraction of power from another thermodynamic gradient, and the second law of thermodynamics imposes fundamental limits on how much power can be extracted. With this approach and associated limits, I show that the ability of abiotic processes to generate geochemical free energy that can be used to transform the surface-atmosphere environment is strongly limited to less than 1 TW. Photosynthetic life generates more than 200 TW by performing photochemistry, thereby substantiating the notion that a geochemical composition far from equilibrium can be a sign for strong biotic activity. Present-day free energy consumption by human activity in the form of industrial activity and human appropriated net primary productivity is of the order of 50 TW and therefore constitutes a considerable term in the free energy budget of the planet. When aiming to predict the future of the planet, we first note that since global changes are closely related to this consumption of free energy, and the demands for free energy by human activity are anticipated to increase substantially in the future, the central question in the context of predicting future global change is then how human free energy demands can increase sustainably without negatively impacting the ability of the Earth system to generate free energy. This question could be evaluated with climate models, and the potential deficiencies in these models to adequately represent the thermodynamics of the Earth system are discussed. Then, I illustrate the implications of this thermodynamic perspective by discussing the forms of renewable energy and planetary engineering that would

  19. Process Improvement for Next Generation Space Flight Vehicles: MSFC Lessons Learned

    Science.gov (United States)

    Housch, Helen

    2008-01-01

    This viewgraph presentation reviews the lessons learned from process improvement for Next Generation Space Flight Vehicles. The contents include: 1) Organizational profile; 2) Process Improvement History; 3) Appraisal Preparation; 4) The Appraisal Experience; 5) Useful Tools; and 6) Is CMMI working?

  20. Application of next generation sequencing in clinical microbiology and infection prevention

    NARCIS (Netherlands)

    Deurenberg, Ruud H.; Bathoorn, Erik; Chlebowicz, Monika A.; Couto, Natacha; Ferdous, Mithila; Garcia-Cobos, Silvia; Kooistra-Smid, Anna M. D.; Raangs, Erwin C.; Rosema, Sigrid; Veloo, Alida C. M.; Zhou, Kai; Friedrich, Alexander W.; Rossen, John W. A.

    2017-01-01

    Current molecular diagnostics of human pathogens provide limited information that is often not sufficient for outbreak and transmission investigation. Next generation sequencing (NGS) determines the DNA sequence of a complete bacterial genome in a single sequence run, and from these data,

  1. Towards the next generation of simplified Dark Matter models

    Science.gov (United States)

    Albert, Andreas; Bauer, Martin; Brooke, Jim; Buchmueller, Oliver; Cerdeño, David G.; Citron, Matthew; Davies, Gavin; de Cosa, Annapaola; De Roeck, Albert; De Simone, Andrea; Du Pree, Tristan; Flaecher, Henning; Fairbairn, Malcolm; Ellis, John; Grohsjean, Alexander; Hahn, Kristian; Haisch, Ulrich; Harris, Philip C.; Khoze, Valentin V.; Landsberg, Greg; McCabe, Christopher; Penning, Bjoern; Sanz, Veronica; Schwanenberger, Christian; Scott, Pat; Wardle, Nicholas

    2017-06-01

    This White Paper is an input to the ongoing discussion about the extension and refinement of simplified Dark Matter (DM) models. It is not intended as a comprehensive review of the discussed subjects, but instead summarises ideas and concepts arising from a brainstorming workshop that can be useful when defining the next generation of simplified DM models (SDMM). In this spirit, based on two concrete examples, we show how existing SDMM can be extended to provide a more accurate and comprehensive framework to interpret and characterise collider searches. In the first example we extend the canonical SDMM with a scalar mediator to include mixing with the Higgs boson. We show that this approach not only provides a better description of the underlying kinematic properties that a complete model would possess, but also offers the option of using this more realistic class of scalar mixing models to compare and combine consistently searches based on different experimental signatures. The second example outlines how a new physics signal observed in a visible channel can be connected to DM by extending a simplified model including effective couplings. In the next part of the White Paper we outline other interesting options for SDMM that could be studied in more detail in the future. Finally, we review important aspects of supersymmetric models for DM and use them to propose how to develop more complete SDMMs. This White Paper is a summary of the brainstorming meeting "Next generation of simplified Dark Matter models" that took place at Imperial College, London on May 6, 2016, and corresponding follow-up studies on selected subjects.

  2. The Gemini Planet Imager Exoplanet Survey

    Science.gov (United States)

    Macintosh, Bruce

    The Gemini Planet Imager (GPI) is a next-generation coronagraph constructed for the Gemini Observatory. GPI will see first light this fall. It will be the most advanced planet-imaging system in operation - an order of magnitude more sensitive than any current instrument, capable of detecting and spectroscopically characterizing young Jovian planets 107 times fainter than their parent star at separations of 0.2 arcseconds. GPI was built from the beginning as a facility-class survey instrument, and the observatory will employ it that way. Our team has been selected by Gemini Observatory to carry out an 890-hour program - the GPI Exoplanet Survey (GPIES) campaign from 2014-2017. We will observe 600 stars spanning spectral types A-M. We will use published young association catalogs and a proprietary list in preparation that adds several hundred new young (pc) and adolescent (pc) stars. The range of separations studied by GPI is completely inaccessible to Doppler and transit techniques (even with Kepler or TESS)— GPI offers a new window into planet formation. We will use GPI to produce the first-ever robust census of giant planet populations in the 5-50 AU range, allowing us to: 1) illuminate the formation pathways of Jovian planets; 2) reconstruct the early dynamical evolution of systems, including migration mechanisms and the interaction with disks and belts of debris; and 3) bridge the gap between Jupiter and the brown dwarfs with the first examples of cool low- gravity planetary atmospheres. Simulations predict this survey will discover approximately 50 exoplanets, increasing the number of exoplanet images by an order of magnitude, enough for statistical investigation. This Origins of Solar Systems proposal will support the execution of the GPI Exoplanet Survey campaign. We will develop tools needed to execute the survey efficiently. We will refine the existing GPI data pipeline to a final version that robustly removes residual speckle artifacts and provides

  3. DARC: Next generation decentralized control framework for robot applications

    DEFF Research Database (Denmark)

    Kjærgaard, Morten; Andersen, Nils Axel; Ravn, Ole

    2013-01-01

    This paper presents DARC, a next generation control framework for robot applications. It is designed to be equally powerful in prototyping research projects and for building serious commercial robots running on low powered embedded hardware, thus closing the gab between research and industry....... It incorporates several new techniques such as a decentralized peer-to-peer architecture, transparent network distribution of the control system, and automatic run-time supervision to guarantee robustness....

  4. Bringing Next-Generation Sequencing into the Classroom through a Comparison of Molecular Biology Techniques

    Science.gov (United States)

    Bowling, Bethany; Zimmer, Erin; Pyatt, Robert E.

    2014-01-01

    Although the development of next-generation (NextGen) sequencing technologies has revolutionized genomic research and medicine, the incorporation of these topics into the classroom is challenging, given an implied high degree of technical complexity. We developed an easy-to-implement, interactive classroom activity investigating the similarities…

  5. Engineered CRISPR Systems for Next Generation Gene Therapies.

    Science.gov (United States)

    Pineda, Michael; Moghadam, Farzaneh; Ebrahimkhani, Mo R; Kiani, Samira

    2017-09-15

    An ideal in vivo gene therapy platform provides safe, reprogrammable, and precise strategies which modulate cell and tissue gene regulatory networks with a high temporal and spatial resolution. Clustered regularly interspaced short palindromic repeats (CRISPR), a bacterial adoptive immune system, and its CRISPR-associated protein 9 (Cas9), have gained attention for the ability to target and modify DNA sequences on demand with unprecedented flexibility and precision. The precision and programmability of Cas9 is derived from its complexation with a guide-RNA (gRNA) that is complementary to a desired genomic sequence. CRISPR systems open-up widespread applications including genetic disease modeling, functional screens, and synthetic gene regulation. The plausibility of in vivo genetic engineering using CRISPR has garnered significant traction as a next generation in vivo therapeutic. However, there are hurdles that need to be addressed before CRISPR-based strategies are fully implemented. Some key issues center on the controllability of the CRISPR platform, including minimizing genomic-off target effects and maximizing in vivo gene editing efficiency, in vivo cellular delivery, and spatial-temporal regulation. The modifiable components of CRISPR systems: Cas9 protein, gRNA, delivery platform, and the form of CRISPR system delivered (DNA, RNA, or ribonucleoprotein) have recently been engineered independently to design a better genome engineering toolbox. This review focuses on evaluating CRISPR potential as a next generation in vivo gene therapy platform and discusses bioengineering advancements that can address challenges associated with clinical translation of this emerging technology.

  6. Direct target NOTES: prospective applications for next generation robotic platforms.

    Science.gov (United States)

    Atallah, S; Hodges, A; Larach, S W

    2018-05-01

    A new era in surgical robotics has centered on alternative access to anatomic targets and next generation designs include flexible, single-port systems which follow circuitous rather than straight pathways. Such systems maintain a small footprint and could be utilized for specialized operations based on direct organ target natural orifice transluminal endoscopic surgery (NOTES), of which transanal total mesorectal excision (taTME) is an important derivative. During two sessions, four direct target NOTES operations were conducted on a cadaveric model using a flexible robotic system to demonstrate proof-of-concept of the application of a next generation robotic system to specific types of NOTES operations, all of which required removal of a direct target organ through natural orifice access. These four operations were (a) robotic taTME, (b) robotic transvaginal hysterectomy in conjunction with (c) robotic transvaginal salpingo-oophorectomy, and in an ex vivo model, (d) trans-cecal appendectomy. Feasibility was demonstrated in all cases using the Flex ® Robotic System with Colorectal Drive. During taTME, the platform excursion was 17 cm along a non-linear path; operative time was 57 min for the transanal portion of the dissection. Robotic transvaginal hysterectomy was successfully completed in 78 min with transvaginal extraction of the uterus, although laparoscopic assistance was required. Robotic transvaginal unilateral salpingo-oophorectomy with transvaginal extraction of the ovary and fallopian tube was performed without laparoscopic assistance in 13.5 min. In an ex vivo model, a robotic trans-cecal appendectomy was also successfully performed for the purpose of demonstrating proof-of-concept only; this was completed in 24 min. A flexible robotic system has the potential to access anatomy along circuitous paths, making it a suitable platform for direct target NOTES. The conceptual operations posed could be considered suitable for next generation robotics once

  7. The Next Generation Science Standards: A Focus on Physical Science

    Science.gov (United States)

    Krajcik, Joe

    2013-01-01

    This article describes ways to adapt U.S. science curriculum to the U.S. National Research Council (NRC) "Framework for K-12 Science Education" and "Next Generation of Science Standards" (NGSS), noting their focus on teaching the physical sciences. The overall goal of the Framework and NGSS is to help all learners develop the…

  8. Research and Development Supporting a Next Generation Germanium Double Beta Decay Experiment

    Science.gov (United States)

    Rielage, Keith; Elliott, Steve; Chu, Pinghan; Goett, Johnny; Massarczyk, Ralph; Xu, Wenqin

    2015-10-01

    To improve the search for neutrinoless double beta decay, the next-generation experiments will increase in source mass and continue to reduce backgrounds in the region of interest. A promising technology for the next generation experiment is large arrays of Germanium p-type point contact detectors enriched in 76-Ge. The experience, expertise and lessons learned from the MAJORANA DEMONSTRATOR and GERDA experiments naturally lead to a number of research and development activities that will be useful in guiding a future experiment utilizing Germanium. We will discuss some R&D activities including a hybrid cryostat design, background reduction in cabling, connectors and electronics, and modifications to reduce assembly time. We acknowledge the support of the U.S. Department of Energy through the LANL/LDRD Program.

  9. Giant Planets of Our Solar System Atmospheres, Composition, and Structure

    CERN Document Server

    Irwin, Patrick G. J

    2009-01-01

    This book reviews the current state of knowledge of the atmospheres of the giant gaseous planets: Jupiter, Saturn, Uranus, and Neptune. The current theories of their formation are reviewed and their recently observed temperature, composition and cloud structures are contrasted and compared with simple thermodynamic, radiative transfer and dynamical models. The instruments and techniques that have been used to remotely measure their atmospheric properties are also reviewed, and the likely development of outer planet observations over the next two decades is outlined. This second edition has been extensively updated following the Cassini mission results for Jupiter/Saturn and the newest ground-based measurements for Uranus/Neptune as well as on the latest development in the theories on planet formation.

  10. Beamstrahlung spectra in next generation linear colliders. Revision

    Energy Technology Data Exchange (ETDEWEB)

    Barklow, T.; Chen, P. [Stanford Linear Accelerator Center, Menlo Park, CA (United States); Kozanecki, W. [DAPNIA-SPP, CEN-Saclay (France)

    1992-04-01

    For the next generation of linear colliders, the energy loss due to beamstrahlung during the collision of the e{sup +}e{sup {minus}} beams is expected to substantially influence the effective center-of-mass energy distribution of the colliding particles. In this paper, we first derive analytical formulae for the electron and photon energy spectra under multiple beamstrahlung processes, and for the e{sup +}e{sup {minus}} and {gamma}{gamma} differential luminosities. We then apply our formulation to various classes of 500 GeV e{sup +}e{sup {minus}} linear collider designs currently under study.

  11. Semantic e-Learning: Next Generation of e-Learning?

    Science.gov (United States)

    Konstantinos, Markellos; Penelope, Markellou; Giannis, Koutsonikos; Aglaia, Liopa-Tsakalidi

    Semantic e-learning aspires to be the next generation of e-learning, since the understanding of learning materials and knowledge semantics allows their advanced representation, manipulation, sharing, exchange and reuse and ultimately promote efficient online experiences for users. In this context, the paper firstly explores some fundamental Semantic Web technologies and then discusses current and potential applications of these technologies in e-learning domain, namely, Semantic portals, Semantic search, personalization, recommendation systems, social software and Web 2.0 tools. Finally, it highlights future research directions and open issues of the field.

  12. A Survey on 5G: The Next Generation of Mobile Communication

    OpenAIRE

    Panwar, Nisha; Sharma, Shantanu; Singh, Awadhesh Kumar

    2015-01-01

    The rapidly increasing number of mobile devices, voluminous data, and higher data rate are pushing to rethink the current generation of the cellular mobile communication. The next or fifth generation (5G) cellular networks are expected to meet high-end requirements. The 5G networks are broadly characterized by three unique features: ubiquitous connectivity, extremely low latency, and very high-speed data transfer. The 5G networks would provide novel architectures and technologies beyond state...

  13. Software R&D for Next Generation of HEP Experiments, Inspired by Theano

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    In the next decade, the frontiers of High Energy Physics (HEP) will be explored by three machines: the High Luminosity Large Hadron Collider (HL-LHC) in Europe, the Long Base Neutrino Facility (LBNF) in the US, and the International Linear Collider (ILC) in Japan. These next generation experiments must address two fundamental problems in the current generation of HEP experimental software: the inability to take advantage and adapt to the rapidly evolving processor landscape, and the difficulty in developing and maintaining increasingly complex software systems by physicists. I will propose a strategy, inspired by the automatic optimization and code generation in Theano, to simultaneously address both problems. I will describe three R&D projects with short-term physics deliverables aimed at developing this strategy. The first project is to develop maximally sensitive General Search for New Physics at the LHC by applying the Matrix Element Method running GPUs of HPCs. The second is to classify and reconstru...

  14. Applications of the Integrated High-Performance CMOS Image Sensor to Range Finders — from Optical Triangulation to the Automotive Field

    Directory of Open Access Journals (Sweden)

    Joe-Air Jiang

    2008-03-01

    Full Text Available With their significant features, the applications of complementary metal-oxidesemiconductor (CMOS image sensors covers a very extensive range, from industrialautomation to traffic applications such as aiming systems, blind guidance, active/passiverange finders, etc. In this paper CMOS image sensor-based active and passive rangefinders are presented. The measurement scheme of the proposed active/passive rangefinders is based on a simple triangulation method. The designed range finders chieflyconsist of a CMOS image sensor and some light sources such as lasers or LEDs. Theimplementation cost of our range finders is quite low. Image processing software to adjustthe exposure time (ET of the CMOS image sensor to enhance the performance oftriangulation-based range finders was also developed. An extensive series of experimentswere conducted to evaluate the performance of the designed range finders. From theexperimental results, the distance measurement resolutions achieved by the active rangefinder and the passive range finder can be better than 0.6% and 0.25% within themeasurement ranges of 1 to 8 m and 5 to 45 m, respectively. Feasibility tests onapplications of the developed CMOS image sensor-based range finders to the automotivefield were also conducted. The experimental results demonstrated that our range finders arewell-suited for distance measurements in this field.

  15. SMITH: a LIMS for handling next-generation sequencing workflows

    OpenAIRE

    Venco, Francesco; Vaskin, Yuriy; Ceol, Arnaud; Muller, Heiko

    2014-01-01

    Background Life-science laboratories make increasing use of Next Generation Sequencing (NGS) for studying bio-macromolecules and their interactions. Array-based methods for measuring gene expression or protein-DNA interactions are being replaced by RNA-Seq and ChIP-Seq. Sequencing is generally performed by specialized facilities that have to keep track of sequencing requests, trace samples, ensure quality and make data available according to predefined privileges. An integrated tool helps to ...

  16. Benchmark problem suite for reactor physics study of LWR next generation fuels

    International Nuclear Information System (INIS)

    Yamamoto, Akio; Ikehara, Tadashi; Ito, Takuya; Saji, Etsuro

    2002-01-01

    This paper proposes a benchmark problem suite for studying the physics of next-generation fuels of light water reactors. The target discharge burnup of the next-generation fuel was set to 70 GWd/t considering the increasing trend in discharge burnup of light water reactor fuels. The UO 2 and MOX fuels are included in the benchmark specifications. The benchmark problem consists of three different geometries: fuel pin cell, PWR fuel assembly and BWR fuel assembly. In the pin cell problem, detailed nuclear characteristics such as burnup dependence of nuclide-wise reactivity were included in the required calculation results to facilitate the study of reactor physics. In the assembly benchmark problems, important parameters for in-core fuel management such as local peaking factors and reactivity coefficients were included in the required results. The benchmark problems provide comprehensive test problems for next-generation light water reactor fuels with extended high burnup. Furthermore, since the pin cell, the PWR assembly and the BWR assembly problems are independent, analyses of the entire benchmark suite is not necessary: e.g., the set of pin cell and PWR fuel assembly problems will be suitable for those in charge of PWR in-core fuel management, and the set of pin cell and BWR fuel assembly problems for those in charge of BWR in-core fuel management. (author)

  17. The DARWIN mission: Search for extra-solar planets

    Science.gov (United States)

    Kaltenegger, L.; Fridlund, M.

    The direct detection of a planet close to its parent star is challenging because the signal detected from the parent star is between 109 and 106 times brighter than the signal of a planet in the visual and IR respectively. Future space based missions like DARWIN and TPF concentrate on the region between 6μ m to 18μ m, a region that contains the CO2, H2O, O3 spectral features of the atmosphere. The presence or absence of these spectral features would indicate similarities or differences with the atmosphere of telluric planets. The Infra Red Space Interferometer DARWIN is an integral part of ESA's Cosmic Vision 2020 plan, intended for a launch towards the middle of next decade. It is constructed around the new technique of `nulling interferometry', which exploits the wave nature of light to extinguish light from an on-axis bright object (the central star in this case), while at the same time light from a nearby source (the planet) is enhanced. An overview and update of the science of the DARWIN mission is given.

  18. Full C-band Tunable MEMS-VCSEL for Next Generation G.metro Mobile Front- and Backhauling

    DEFF Research Database (Denmark)

    Wagner, Christoph; Zou, Shihuan Jim; Ortsiefer, Markus

    2017-01-01

    We report full C-band tunable, 10 Gbit/s capability, directly modulated MEMS-VCSEL for next generation converged mobile fronthaul and backhaul applications. Bit error rates below 10(-9) were achieved over up to 40 km SSMF.......We report full C-band tunable, 10 Gbit/s capability, directly modulated MEMS-VCSEL for next generation converged mobile fronthaul and backhaul applications. Bit error rates below 10(-9) were achieved over up to 40 km SSMF....

  19. The "Next Generation Science Standards" and the Earth and Space Sciences

    Science.gov (United States)

    Wysession, Michael E.

    2013-01-01

    The "Next Generation Science Standards" ("NGSS"), due to be released this spring, represents a revolutionary step toward establishing modern, national K-12 science education standards. Based on the recommendations of the National Research Council's "A Framework for K-12 Science Education: Practices, Crosscutting…

  20. A framework for QoS & mobility in the Internet next generation

    NARCIS (Netherlands)

    Rexhepi, Vlora; Karagiannis, Georgios; Heijenk, Geert; Pras, Aiko

    2000-01-01

    It is expected that the Internet next generation architecture will support applications with different quality of service requirements, independently of whether their location is fixed or mobile. However, enabling QoS in Internet is a tough challenge, and it gets even tougher when the mobile

  1. A framework for QoS & mobility in the Internet next generation

    NARCIS (Netherlands)

    Karagiannis, Georgios; Rexhepi, Vlora; Heijenk, Geert

    It is expected that the next generation Internet architecture will support applications with different quality of service requirements, independently of whether their location is fixed or movable. However, enabling QoS in Internet is a tough challenge, and it gets even tougher when the mobile

  2. Multi-Stage Admission Control for Load Balancing in Next Generation Systems

    DEFF Research Database (Denmark)

    Mihovska, Albena D.; Anggorojati, Bayu; Luo, Jijun

    2008-01-01

    This paper describes a load-dependent multi-stage admission control suitable for next generation systems. The concept uses decision polling in entities located at different levels of the architecture hierarchy and based on the load to activate a sequence of actions related to the admission...

  3. Implementation of defence in depth for next generation light water reactors

    International Nuclear Information System (INIS)

    1997-12-01

    The publication of this IAEA technical document represents the conclusion of a task, initiated in 1995, devoted to defence in depth in future reactors. It focuses mainly on the next generation of LWRs, although many general considerations may also apply to other types of reactors

  4. Acquisition Of Three-Dimensional Image Data By A Scanning Laser Range Finder

    Science.gov (United States)

    Moring, I.; Heikkinen, T.; Myllyla, R.; Kilpela, A. T.

    1989-08-01

    We describe a 3-D vision system designed and constructed at the Technical Research Centre of Finland in cooperation with the University of Oulu. The system was developed chiefly for geometric measurements of large objects. The system has been operative for about one year, and its performance has been extensively tested. The system consists of three main units: the range finder, the scanner, and the computer. The range finder is based on the direct measurement of the time-of-flight of a laser pulse. The scanner consists of two mirrors driven by moving iron galvanometers; this unit is controlled by servo amplifiers. The computer controls the scanner, transforms the measured coordinates into a Cartesian coordinate system, and serves as a user interface and postprocessing environment.

  5. Next Generation Science Partnerships

    Science.gov (United States)

    Magnusson, J.

    2016-02-01

    I will provide an overview of the Next Generation Science Standards (NGSS) and demonstrate how scientists and educators can use these standards to strengthen and enhance their collaborations. The NGSS are rich in content and practice and provide all students with an internationally-benchmarked science education. Using these state-led standards to guide outreach efforts can help develop and sustain effective and mutually beneficial teacher-researcher partnerships. Aligning outreach with the three dimensions of the standards can help make research relevant for target audiences by intentionally addressing the science practices, cross-cutting concepts, and disciplinary core ideas of the K-12 science curriculum that drives instruction and assessment. Collaborations between researchers and educators that are based on this science framework are more sustainable because they address the needs of both scientists and educators. Educators are better able to utilize science content that aligns with their curriculum. Scientists who learn about the NGSS can better understand the frameworks under which educators work, which can lead to more extensive and focused outreach with teachers as partners. Based on this model, the International Ocean Discovery Program (IODP) develops its education materials in conjunction with scientists and educators to produce accurate, standards-aligned activities and curriculum-based interactions with researchers. I will highlight examples of IODP's current, successful teacher-researcher collaborations that are intentionally aligned with the NGSS.

  6. Hydrothermal systems in small ocean planets.

    Science.gov (United States)

    Vance, Steve; Harnmeijer, Jelte; Kimura, Jun; Hussmann, Hauke; Demartin, Brian; Brown, J Michael

    2007-12-01

    We examine means for driving hydrothermal activity in extraterrestrial oceans on planets and satellites of less than one Earth mass, with implications for sustaining a low level of biological activity over geological timescales. Assuming ocean planets have olivine-dominated lithospheres, a model for cooling-induced thermal cracking shows how variation in planet size and internal thermal energy may drive variation in the dominant type of hydrothermal system-for example, high or low temperature system or chemically driven system. As radiogenic heating diminishes over time, progressive exposure of new rock continues to the current epoch. Where fluid-rock interactions propagate slowly into a deep brittle layer, thermal energy from serpentinization may be the primary cause of hydrothermal activity in small ocean planets. We show that the time-varying hydrostatic head of a tidally forced ice shell may drive hydrothermal fluid flow through the seafloor, which can generate moderate but potentially important heat through viscous interaction with the matrix of porous seafloor rock. Considering all presently known potential ocean planets-Mars, a number of icy satellites, Pluto, and other trans-neptunian objects-and applying Earth-like material properties and cooling rates, we find depths of circulation are more than an order of magnitude greater than in Earth. In Europa and Enceladus, tidal flexing may drive hydrothermal circulation and, in Europa, may generate heat on the same order as present-day radiogenic heat flux at Earth's surface. In all objects, progressive serpentinization generates heat on a globally averaged basis at a fraction of a percent of present-day radiogenic heating and hydrogen is produced at rates between 10(9) and 10(10) molecules cm(2) s(1).

  7. Next Generation Nuclear Plant Project Technology Development Roadmaps: The Technical Path Forward

    Energy Technology Data Exchange (ETDEWEB)

    John Collins

    2009-01-01

    This document presents the Next Generation Nuclear Plant (NGNP) Systems, Subsystems, and Components, establishes a baseline for the current technology readiness status, and provides a path forward to achieve increasing levels of technical maturity.

  8. The "Next Generation Science Standards" and the Earth and Space Sciences

    Science.gov (United States)

    Wysession, Michael E.

    2013-01-01

    In this article, Michael E. Wysession comments on the "Next Generation Science Standards" (NGSS), which are based on the recommendations of the National Research Council and represent a revolutionary step toward establishing modern, national K-12 science education standards. The NGSS involves significant changes from traditional…

  9. Next generation in-situ optical Raman sensor for seawater investigations

    Science.gov (United States)

    Kolomijeca, A.; Kwon, Y.-H.; Ahmad, H.; Kronfeldt, H.-D.

    2012-04-01

    We introduce the next generation of optical sensors based on a combination of surfaced enhanced Raman scattering (SERS) and shifted excitation Raman difference spectroscopy (SERDS) suited for investigations of tiny concentrations of pollutions in the seawater. First field measurements were carried out in the Arctic area which is of global interest since it is more affected by global warming caused climatic changes than any other areas of our planet and it is a recipient for many toxic organic pollutants. A significant long-range atmospheric transport of pollutants to Svalbard is mainly originated from industrialized countries in Europe and North America during the last decades. Therefore, the main interest is to investigate the Arctic water column and also the sediments. Standard chemical methods for water/sediment analysis are extremely accurate but complex and time-consuming. The primary objective of our study was to develop a fast response in-situ optical sensor for easy to use and quick analysis. The system comprises several components: a handheld measurement head containing a 671 nm microsystem diode laser and the Raman optical bench, a laser driver electronics board, a custom-designed miniature spectrometer with an optical resolution of 8 cm-1 and a netbook to control the spectrometer as well as for data evaluation. We introduced for the first time the portable Raman sensor system on an Artic sea-trial during a three week cruise on board of the James Clark Ross research vessel in August 2011. Numerous Raman and SERS measurements followed by SERDS evaluations were taken around locations 78° N and 9° E. Different SERS substrates developed for SERS measurements in sea-water were tested for their capability to detect different substances (PAHs) in the water down to very small (nmol/l) concentrations. Stability tests of the substrates were carried out also for the applicability of our system e.g. on a mooring. Details of the in-situ Raman sensor were presented

  10. Informing the next nuclear generation - how does the Ginna plant branch do it?

    International Nuclear Information System (INIS)

    Saavedra, A.

    1995-01-01

    Most of us are familiar with the latest advertising phrase, ''Our children are our future.'' This phrase has been used in so many instances - from concerns about waste, Social Security, and the federal deficit to drug abuse and violence. One more area can be added to the list and advertised nuclear power. Since the establishment of the Ginna plant branch (GPB) in 1992, our target audience has been the next nuclear generation (our children), but our vehicle for dissemination has been the current generation (the adults). Have you ever thought about how often your opinions affect the children you come in contact with? One of GPB's goals is to provide as much information as possible to teachers, neighbors, and civic organizations of our community so that there is a nuclear future that can be carried on by the next generation

  11. Towards identifying the next generation of superfund and hazardous waste site contaminants

    Science.gov (United States)

    Ela, Wendell P.; Sedlak, David L.; Barlaz, Morton A.; Henry, Heather F.; Muir, Derek C.G.; Swackhamer, Deborah L.; Weber, Eric J.; Arnold, Robert G.; Ferguson, P. Lee; Field, Jennifer A.; Furlong, Edward T.; Giesy, John P.; Halden, Rolf U.; Henry, Tala; Hites, Ronald A.; Hornbuckle, Keri C.; Howard, Philip H.; Luthy, Richard G.; Meyer, Anita K.; Saez, A. Eduardo; vom Saal, Frederick S.; Vulpe, Chris D.; Wiesner, Mark R.

    2011-01-01

    Background This commentary evolved from a workshop sponsored by the National Institute of Environmental Health Sciences titled "Superfund Contaminants: The Next Generation" held in Tucson, Arizona, in August 2009. All the authors were workshop participants.

  12. Groupies and Loners: The Population of Multi-planet Systems

    Science.gov (United States)

    Van Laerhoven, Christa L.; Greenberg, Richard

    2014-11-01

    Observational surveys with Kepler and other telescopes have shown that multi-planet systems are very numerous. Considering the secular dynamcis of multi-planet systems provides substantial insight into the interactions between planets in those systems. Since the underlying secular structure of a multi-planet system (the secular eigenmodes) can be calculated using only the planets' masses and semi-major axes, one can elucidate the eccentricity and inclination behavior of planets in those systems even without knowing the planets' current eccentricities and inclinations. We have calculated both the eccentricity and inclination secular eigenmodes for the population of known multi-planet systems whose planets have well determined masses and periods. We will discuss the commonality of dynamically grouped planets ('groupies') vs dynamically uncoupled planets ('loners'), and compare to what would be expected from randomly generated systems with the same overall distribution of masses and semi-major axes. We will also discuss the occurrence of planets that strongly influence the behavior of other planets without being influenced by those others ('overlords'). Examples will be given and general trends will be discussed.

  13. Fiscal Year 2014 Annual Report on BNLs Next Generation Safeguards Initiative Human Capital Development Activities

    Energy Technology Data Exchange (ETDEWEB)

    Pepper, Susan E. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2014-10-10

    Brookhaven National Laboratory’s (BNL’s) Nonproliferation and National Security Department contributes to the National Nuclear Security Administration Office of Nonproliferation and International Security Next Generation Safeguards Initiative (NGSI) through university engagement, safeguards internships, safeguards courses, professional development, recruitment, and other activities aimed at ensuring the next generation of international safeguards professionals is adequately prepared to support the U.S. safeguards mission. This report is a summary of BNL s work under the NGSI program in Fiscal Year 2014.

  14. On the ergodic capacity of legacy systems in the presence of next generation interference

    KAUST Repository

    Mahmood, Nurul Huda

    2011-11-01

    Next generation wireless systems facilitating better utilization of the scarce radio spectrum have emerged as a response to inefficient rigid spectrum assignment policies. These are comprised of intelligent radio nodes that opportunistically operate in the radio spectrum of existing legacy systems; yet unwanted interference at the legacy receivers is unavoidable. In order to design efficient next generation systems and to minimize their harmful consequences, it is necessary to realize their impact on the performance of legacy systems. In this work, a generalized framework for the ergodic capacity analysis of such legacy systems in the presence of interference from next generation systems is presented. The analysis is built around a model developed for the statistical representation of the interference at the legacy receivers, which is then used to evaluate the ergodic capacity of the legacy system. Moreover, this analysis is not limited to the context of legacy systems, and is in fact applicaple to any interference limited system. Findings of analytical performance analyses are confirmed through selected computer-based Monte-Carlo simulations. © 2011 IEEE.

  15. Next Generation Campus Network Deployment Project Based on Softswitch

    OpenAIRE

    HU Feng; LIU Ziyan

    2011-01-01

    After analyzing the current networks of Guizhou University,we brought forward a scheme of next generation campus networks based on softswitch technology by choosing SoftX3000 switching system of HuaWei and provided the specific solution of accessing campus networks in this paper. It is proved that this scheme is feasible by using OPNET, which not only accomplished the integration of the PSTN and IP networks but also achieved the combining of voice services and data services.

  16. Applying Next Generation Sequencing to Skeletal Development and Disease

    OpenAIRE

    Bowen, Margot Elizabeth

    2013-01-01

    Next Generation Sequencing (NGS) technologies have dramatically increased the throughput and lowered the cost of DNA sequencing. In this thesis, I apply these technologies to unresolved questions in skeletal development and disease. Firstly, I use targeted re-sequencing of genomic DNA to identify the genetic cause of the cartilage tumor syndrome, metachondromatosis (MC). I show that the majority of MC patients carry heterozygous loss-of-function mutations in the PTPN11 gene, which encodes a p...

  17. Next Generation Qualification: Nanometrics T120PH Seismometer Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Merchant, Bion J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Slad, George William [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-10-01

    Sandia National Laboratories has tested and evaluated three seismometers, the Trillium 120PH, manufactured by Nanometrics. These seismometers measure broadband ground velocity using a UVW configuration with feedback control in a mechanically levelled borehole package. The purpose of the seismometer evaluation was to determine a measured sensitivity, response, self- noise, dynamic range, and self-calibration ability. The Nanometrics Trillium 120PH seismometers are being evaluated for the U.S. Air Force as part of their Next Generation Qualification effort.

  18. PointFinder: a novel web tool for WGS-based detection of antimicrobial resistance associated with chromosomal point mutations in bacterial pathogens

    DEFF Research Database (Denmark)

    Zankari, Ea; Allesøe, Rosa Lundbye; Joensen, Katrine Grimstrup

    2017-01-01

    enterica, Escherichia coli and Campylobacter jejuni. The web-server ResFinder-2.1 was used to identify acquired antimicrobial resistance genes and two methods, the novel PointFinder (using BLAST) and an in-house method (mapping of raw WGS reads), were used to identify chromosomal point mutations. Results...... or when mapping the reads. Conclusions PointFinder proved, with high concordance between phenotypic and predicted antimicrobial susceptibility, to be a user-friendly web tool for detection of chromosomal point mutations associated with antimicrobial resistance....

  19. Power Electronics for the Next Generation Wind Turbine System

    DEFF Research Database (Denmark)

    Ma, Ke

    generation unit, are becoming crucial in the wind turbine system. The objective of this project is to study the power electronics technology used for the next generation wind turbines. Some emerging challenges as well as potentials like the cost of energy and reliability are going to be addressed. First...... conversion is pushed to multi-MW level with high power density requirement. It has also been revealed that thermal stress in the power semiconductors is closely related to many determining factors in the wind power application like the reliability, cost, power density, etc. therefore it is an important......The wind power generation has been steadily growing both for the total installed capacity and for the individual turbine size. Due to much more significant impacts to the power grid, the power electronics, which can change the behavior of wind turbines from an unregulated power source to an active...

  20. Detection of TET2, KRAS and CBL variants by Next Generation ...

    African Journals Online (AJOL)

    Dilara Fatma Akin

    2015-10-01

    Oct 1, 2015 ... sarcoma viral oncogene homolog (KRAS), and Casitas B-cell ... AML by screening hot-spot exons of TET2, KRAS, and CBL using Next Generation Sequencing ... Methods: Eight patients who were diagnosed with pediatric AML at Losante ..... mutations in pre-leukemic stem cells in acute myeloid leukemia.

  1. Teaching the "Geo" in Geography with the Next Generation Science Standards

    Science.gov (United States)

    Wysession, Michael E.

    2016-01-01

    The Next Generation Science Standards (NGSS; Achieve 2014, 532; Figure 1A) represent a new approach to K-12 science education that involves the interweaving of three educational dimensions: Science and Engineering Practices (SEPs), Disciplinary Core Ideas (DCIs), and Crosscutting Concepts (CCCs). Unlike most preexisting state science standards for…

  2. Next Generation Science Standards: Considerations for Curricula, Assessments, Preparation, and Implementation

    Science.gov (United States)

    Best, Jane; Dunlap, Allison

    2014-01-01

    This policy brief provides an overview of the Next Generation Science Standards (NGSS), discusses policy considerations for adopting or adapting the new standards, and presents examples from states considering or implementing the NGSS. Changing academic standards is a complex process that requires significant investments of time, money, and human…

  3. Am I my Family's Keeper? : Disclosure Dilemmas in Next Generation Sequencing

    NARCIS (Netherlands)

    Wouters, Roel H P; Bijlsma, Rhodé M; Ausems, Margreet G E M; van Delden, Johannes J M; Voest, Emile E; Bredenoord, Annelien L

    2016-01-01

    Ever since genetic testing is possible for specific mutations, ethical debate has sparked on the question of whether professionals have a duty to warn not only patients but also their relatives that might be at risk for hereditary diseases. As next generation sequencing swiftly finds its way into

  4. Report on the September 2011 Meeting of the Next Generation Safegaurds Professional Network

    Energy Technology Data Exchange (ETDEWEB)

    Gitau, Ernest TN; Benz, Jacob M.

    2011-12-19

    The Next Generation Safeguards Professional Network (NGSPN) was established in 2009 by Oak Ridge National Laboratory targeted towards the engagement of young professionals employed in safeguards across the many national laboratories. NGSPN focuses on providing a mechanism for young safeguards professionals to connect and foster professional relationships, facilitating knowledge transfer between current safeguards experts and the next generation of experts, and acting as an entity to represent the interests of the international community of young and mid-career safeguards professionals. This is accomplished in part with a yearly meeting held at a national laboratory site. In 2011, this meeting was held at Pacific Northwest National Laboratory. This report documents the events and results of that meeting.

  5. Diamond Light Source - A Next Generation SR Facility

    International Nuclear Information System (INIS)

    Materlik, G.

    2004-01-01

    After the very successful start and the by now almost 10 years operation of the 3rd generation x-ray sources ESRF, APS and Spring-8 smaller storage rings are being planned and constructed with properties emphasising applications with photon energies around the 10 keV spectral region. In the UK the Government and the medical foundation Wellcome Trust have decided to build the Diamond Light Source Facility in the South of Oxfordshire right next to the Rutherford Appleton Laboratory. The joint venture company Diamond Light Source Limited has been created to plan, construct, and operate this facility. (author)

  6. Next generation framework for aquatic modeling of the Earth System

    Science.gov (United States)

    Fekete, B. M.; Wollheim, W. M.; Wisser, D.; Vörösmarty, C. J.

    2009-03-01

    Earth System model development is becoming an increasingly complex task. As scientists attempt to represent the physical and bio-geochemical processes and various feedback mechanisms in unprecedented detail, the models themselves are becoming increasingly complex. At the same time, the complexity of the surrounding IT infrastructure is growing as well. Earth System models must manage a vast amount of data in heterogeneous computing environments. Numerous development efforts are on the way to ease that burden and offer model development platforms that reduce IT challenges and allow scientists to focus on their science. While these new modeling frameworks (e.g. FMS, ESMF, CCA, OpenMI) do provide solutions to many IT challenges (performing input/output, managing space and time, establishing model coupling, etc.), they are still considerably complex and often have steep learning curves. The Next generation Framework for Aquatic Modeling of the Earth System (NextFrAMES, a revised version of FrAMES) have numerous similarities to those developed by other teams, but represents a novel model development paradigm. NextFrAMES is built around a modeling XML that lets modelers to express the overall model structure and provides an API for dynamically linked plugins to represent the processes. The model XML is executed by the NextFrAMES run-time engine that parses the model definition, loads the module plugins, performs the model I/O and executes the model calculations. NextFrAMES has a minimalistic view representing spatial domains and treats every domain (regardless of its layout such as grid, network tree, individual points, polygons, etc.) as vector of objects. NextFrAMES performs computations on multiple domains and interactions between different spatial domains are carried out through couplers. NextFrAMES allows processes to operate at different frequencies by providing rudimentary aggregation and disaggregation facilities. NextFrAMES was designed primarily for

  7. Safety design philosophy of the ABWR for the next generation LWRs

    International Nuclear Information System (INIS)

    Sato, Takashi; Akinaga, Makoto; Kojima, Yoshihiro

    2009-01-01

    The paper presents safety design philosophy of the advanced boiling water reactor (ABWR) to be reflected in developing the next generation light water reactors (LWRs). The basic policy of the ABWR safety design was to improve safety and reduce cost simultaneously by reflecting lessons learned of precursors, incidents and accidents that were beyond the design basis such as the Three Mile Island Unit 2 (TMI 2) accident. The ABWR is a fully active safety plant. The ABWR enhanced redundancy and diversity of active safety systems using probabilistic safety assessment (PSA) insights. It adopted a complete three division active emergency core cooling system (ECCS) and attained a very low core damage frequency (CDF) value of less than 10 -7 /ry for internal events. Only very small residual risks, if any, rather exist in external events such as an extremely large earthquake beyond the design basis. This is because external events can constitute a common cause that disables all the redundant active safety systems. Therefore, it is useless to add one more ECCS train and make a four division active ECCS for external events. Nowadays, however, fully passive safety LWRs are already established. Incorporating some of these passive safety systems we can also establish the next generation LWRs that are truly strong against external events. We can establish a plant that can survive a giant earthquake at least three days without AC power source, SA proof safety design that enables no containment failure and no evacuation to eliminate the residual risks. The same basic policy as the ABWR to improve safety and reduce cost simultaneously is again effective for the next generation LWRs. (author)

  8. Target & Propagation Models for the FINDER Radar

    Science.gov (United States)

    Cable, Vaughn; Lux, James; Haque, Salmon

    2013-01-01

    Finding persons still alive in piles of rubble following an earthquake, a severe storm, or other disaster is a difficult problem. JPL is currently developing a victim detection radar called FINDER (Finding Individuals in Emergency and Response). The subject of this paper is directed toward development of propagation & target models needed for simulation & testing of such a system. These models are both physical (real rubble piles) and numerical. Early results from the numerical modeling phase show spatial and temporal spreading characteristics when signals are passed through a randomly mixed rubble pile.

  9. Molecular Diagnostics in Pathology: Time for a Next-Generation Pathologist?

    Science.gov (United States)

    Fassan, Matteo

    2018-03-01

    - Comprehensive molecular investigations of mainstream carcinogenic processes have led to the use of effective molecular targeted agents in most cases of solid tumors in clinical settings. - To update readers regarding the evolving role of the pathologist in the therapeutic decision-making process and the introduction of next-generation technologies into pathology practice. - Current literature on the topic, primarily sourced from the PubMed (National Center for Biotechnology Information, Bethesda, Maryland) database, were reviewed. - Adequate evaluation of cytologic-based and tissue-based predictive diagnostic biomarkers largely depends on both proper pathologic characterization and customized processing of biospecimens. Moreover, increased requests for molecular testing have paralleled the recent, sharp decrease in tumor material to be analyzed-material that currently comprises cytology specimens or, at minimum, small biopsies in most cases of metastatic/advanced disease. Traditional diagnostic pathology has been completely revolutionized by the introduction of next-generation technologies, which provide multigene, targeted mutational profiling, even in the most complex of clinical cases. Combining traditional and molecular knowledge, pathologists integrate the morphological, clinical, and molecular dimensions of a disease, leading to a proper diagnosis and, therefore, the most-appropriate tailored therapy.

  10. Data-Driven Handover Optimization in Next Generation Mobile Communication Networks

    Directory of Open Access Journals (Sweden)

    Po-Chiang Lin

    2016-01-01

    Full Text Available Network densification is regarded as one of the important ingredients to increase capacity for next generation mobile communication networks. However, it also leads to mobility problems since users are more likely to hand over to another cell in dense or even ultradense mobile communication networks. Therefore, supporting seamless and robust connectivity through such networks becomes a very important issue. In this paper, we investigate handover (HO optimization in next generation mobile communication networks. We propose a data-driven handover optimization (DHO approach, which aims to mitigate mobility problems including too-late HO, too-early HO, HO to wrong cell, ping-pong HO, and unnecessary HO. The key performance indicator (KPI is defined as the weighted average of the ratios of these mobility problems. The DHO approach collects data from the mobile communication measurement results and provides a model to estimate the relationship between the KPI and features from the collected dataset. Based on the model, the handover parameters, including the handover margin and time-to-trigger, are optimized to minimize the KPI. Simulation results show that the proposed DHO approach could effectively mitigate mobility problems.

  11. High-performance ferroelectric and magnetoresistive materials for next-generation thermal detector arrays

    Science.gov (United States)

    Todd, Michael A.; Donohue, Paul P.; Watton, Rex; Williams, Dennis J.; Anthony, Carl J.; Blamire, Mark G.

    2002-12-01

    This paper discusses the potential thermal imaging performance achievable from thermal detector arrays and concludes that the current generation of thin-film ferroelectric and resistance bolometer based detector arrays are limited by the detector materials used. It is proposed that the next generation of large uncooled focal plane arrays will need to look towards higher performance detector materials - particularly if they aim to approach the fundamental performance limits and compete with cooled photon detector arrays. Two examples of bolometer thin-film materials are described that achieve high performance from operating around phase transitions. The material Lead Scandium Tantalate (PST) has a paraelectric-to-ferroelectric phase transition around room temperature and is used with an applied field in the dielectric bolometer mode for thermal imaging. PST films grown by sputtering and liquid-source CVD have shown merit figures for thermal imaging a factor of 2 to 3 times higher than PZT-based pyroelectric thin films. The material Lanthanum Calcium Manganite (LCMO) has a paramagnetic to ferromagnetic phase transition around -20oC. This paper describes recent measurements of TCR and 1/f noise in pulsed laser-deposited LCMO films on Neodymium Gallate substrates. These results show that LCMO not only has high TCR's - up to 30%/K - but also low 1/f excess noise, with bolometer merit figures at least an order of magnitude higher than Vanadium Oxide, making it ideal for the next generation of microbolometer arrays. These high performance properties come at the expense of processing complexities and novel device designs will need to be introduced to realize the potential of these materials in the next generation of thermal detectors.

  12. Estabilishing requirements for the next generation of pressurized water reactors--reducing the uncertainty

    International Nuclear Information System (INIS)

    Chernock, W.P.; Corcoran, W.R.; Rasin, W.H.; Stahlkopf, K.E.

    1987-01-01

    The Electric Power Research Institute is managing a major effort to establish requirements for the next generation of U.S. light water reactors. This effort is the vital first step in preserving the viability of the nuclear option to contribute to meet U.S. national electric power capacity needs in the next century. Combustion Engineering, Inc. and Duke Power Company formed a team to participate in the EPRI program which is guided by a Utility Steering committee consisting of experienced utility technical executives. A major thrust of the program is to reduce the uncertainties which would be faced by the utility executives in choosing the nuclear option. The uncertainties to be reduced include those related to safety, economic, operational, and regulatory aspects of advanced light water reactors. This paper overviews the Requirements Document program as it relates to the U.S. Advanced Light Water Reactor (ALWR) effort in reducing these uncertainties and reports the status of efforts to establish requirements for the next generation of pressurized water reactors. It concentrates on progress made in reducing the uncertainties which would deter selection of the nuclear option for contributing to U.S. national electric power capacity needs in the next century and updates previous reports in the same area. (author)

  13. NGSUtils: a software suite for analyzing and manipulating next-generation sequencing datasets

    OpenAIRE

    Breese, Marcus R.; Liu, Yunlong

    2013-01-01

    Summary: NGSUtils is a suite of software tools for manipulating data common to next-generation sequencing experiments, such as FASTQ, BED and BAM format files. These tools provide a stable and modular platform for data management and analysis.

  14. Design Features and Technology Uncertainties for the Next Generation Nuclear Plant

    Energy Technology Data Exchange (ETDEWEB)

    John M. Ryskamp; Phil Hildebrandt; Osamu Baba; Ron Ballinger; Robert Brodsky; Hans-Wolfgang Chi; Dennis Crutchfield; Herb Estrada; Jeane-Claude Garnier; Gerald Gordon; Richard Hobbins; Dan Keuter; Marilyn Kray; Philippe Martin; Steve Melancon; Christian Simon; Henry Stone; Robert Varrin; Werner von Lensa

    2004-06-01

    This report presents the conclusions, observations, and recommendations of the Independent Technology Review Group (ITRG) regarding design features and important technology uncertainties associated with very-high-temperature nuclear system concepts for the Next Generation Nuclear Plant (NGNP). The ITRG performed its reviews during the period November 2003 through April 2004.

  15. Next-Generation Bio-Products Sowing the Seeds of Success for Sustainable Agriculture

    Directory of Open Access Journals (Sweden)

    Henry Müller

    2013-10-01

    Full Text Available Plants have recently been recognized as meta-organisms due to a close symbiotic relationship with their microbiome. Comparable to humans and other eukaryotic hosts, plants also harbor a “second genome” that fulfills important host functions. These advances were driven by both “omics”-technologies guided by next-generation sequencing and microscopic insights. Additionally, these new results influence applied fields such as biocontrol and stress protection in agriculture, and new tools may impact (i the detection of new bio-resources for biocontrol and plant growth promotion, (ii the optimization of fermentation and formulation processes for biologicals, (iii stabilization of the biocontrol effect under field conditions, and (iv risk assessment studies for biotechnological applications. Examples are presented and discussed for the fields mentioned above, and next-generation bio-products were found as a sustainable alternative for agriculture.

  16. Measuring Precise Radii of Giants Orbiting Giants to Distinguish Between Planet Evolution Models

    Science.gov (United States)

    Grunblatt, Samuel; Huber, Daniel; Lopez, Eric; Gaidos, Eric; Livingston, John

    2017-10-01

    Despite more than twenty years since the initial discovery of highly irradiated gas giant planets, the mechanism for planet inflation remains unknown. However, proposed planet inflation mechanisms can now be separated into two general classes: those which allow for post-main sequence planet inflation by direct irradiation from the host star, and those which only allow for slowed cooling of the planet over its lifetime. The recent discovery of two inflated warm Jupiters orbiting red giant stars with the NASA K2 Mission allows distinction between these two classes, but uncertainty in the planet radius blurs this distinction. Observing transits of these planets with the Spitzer Space Telescope would reduce stellar variability and thus planet radius uncertainties by approximately 50% relative to K2, allowing distinction between the two planet inflation model classes at a 3-sigma level. We propose to observe one transit of both known warm Jupiters orbiting red giant stars, K2-97b and EPIC228754001.01, to distinguish between planet model inflation classes and measure the planetary heating efficiency to 3-sigma precision. These systems are benchmarks for the upcoming NASA TESS Mission, which is predicted to discover an order of magnitude more red giant planet systems after launching next year.

  17. Nucleic acid reactivity : challenges for next-generation semiempirical quantum models

    OpenAIRE

    Huang, Ming; Giese, Timothy J.; York, Darrin M.

    2015-01-01

    Semiempirical quantum models are routinely used to study mechanisms of RNA catalysis and phosphoryl transfer reactions using combined quantum mechanical/molecular mechanical methods. Herein, we provide a broad assessment of the performance of existing semiempirical quantum models to describe nucleic acid structure and reactivity in order to quantify their limitations and guide the development of next-generation quantum models with improved accuracy. Neglect of diatomic diffierential overlap (...

  18. NREL Next Generation Drivetrain: Mechanical Design and Test Plan (Poster)

    Energy Technology Data Exchange (ETDEWEB)

    Keller, J.; Halse, C.

    2014-05-01

    The Department of Energy and industry partners are sponsoring a $3m project for design and testing of a 'Next Generation' wind turbine drivetrain at the National Renewable Energy Laboratory (NREL). This poster focuses on innovative aspects of the gearbox design, completed as part of an end-to-end systems engineering approach incorporating innovations that increase drivetrain reliability, efficiency, torque density and minimize capital cost.

  19. NNSA Program Develops the Next Generation of Nuclear Security Experts

    Energy Technology Data Exchange (ETDEWEB)

    Brim, Cornelia P.; Disney, Maren V.

    2015-09-02

    NNSA is fostering the next generation of nuclear security experts is through its successful NNSA Graduate Fellowship Program (NGFP). NGFP offers its Fellows an exceptional career development opportunity through hands-on experience supporting NNSA mission areas across policy and technology disciplines. The one-year assignments give tomorrow’s leaders in global nuclear security and nonproliferation unparalleled exposure through assignments to Program Offices across NNSA.

  20. Next Generation Qualification: Kinemetrics STS-5A Seismometer Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Merchant, Bion John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Slad, George William [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-10-01

    Sandia National Laboratories has tested and evaluated two seismometers, the STS-5A, manufactured by Kinemetrics. These seismometers measure three axes of broadband ground velocity using a UVW configuration with feedback control in a mechanically levelled borehole package. The purpose of the seismometer evaluation was to determine a measured sensitivity, response, self-noise, dynamic range, and self-calibration ability. The Kinemetrics STS-5A seismometers are being evaluated for the U.S. Air Force as part of their Next Generation Qualification effort.

  1. Estimation of allele frequency and association mapping using next-generation sequencing data

    DEFF Research Database (Denmark)

    Kim, Su Yeon; Lohmueller, Kirk E; Albrechtsen, Anders

    2011-01-01

    Estimation of allele frequency is of fundamental importance in population genetic analyses and in association mapping. In most studies using next-generation sequencing, a cost effective approach is to use medium or low-coverage data (e.g., frequency estimation...

  2. CRISPRCasFinder, an update of CRISRFinder, includes a portable version, enhanced performance and integrates search for Cas proteins.

    Science.gov (United States)

    Couvin, David; Bernheim, Aude; Toffano-Nioche, Claire; Touchon, Marie; Michalik, Juraj; Néron, Bertrand; C Rocha, Eduardo P; Vergnaud, Gilles; Gautheret, Daniel; Pourcel, Christine

    2018-05-22

    CRISPR (clustered regularly interspaced short palindromic repeats) arrays and their associated (Cas) proteins confer bacteria and archaea adaptive immunity against exogenous mobile genetic elements, such as phages or plasmids. CRISPRCasFinder allows the identification of both CRISPR arrays and Cas proteins. The program includes: (i) an improved CRISPR array detection tool facilitating expert validation based on a rating system, (ii) prediction of CRISPR orientation and (iii) a Cas protein detection and typing tool updated to match the latest classification scheme of these systems. CRISPRCasFinder can either be used online or as a standalone tool compatible with Linux operating system. All third-party software packages employed by the program are freely available. CRISPRCasFinder is available at https://crisprcas.i2bc.paris-saclay.fr.

  3. Next Generation Agricultural System Data, Models and Knowledge Products: Introduction

    Science.gov (United States)

    Antle, John M.; Jones, James W.; Rosenzweig, Cynthia E.

    2016-01-01

    Agricultural system models have become important tools to provide predictive and assessment capability to a growing array of decision-makers in the private and public sectors. Despite ongoing research and model improvements, many of the agricultural models today are direct descendants of research investments initially made 30-40 years ago, and many of the major advances in data, information and communication technology (ICT) of the past decade have not been fully exploited. The purpose of this Special Issue of Agricultural Systems is to lay the foundation for the next generation of agricultural systems data, models and knowledge products. The Special Issue is based on a 'NextGen' study led by the Agricultural Model Intercomparison and Improvement Project (AgMIP) with support from the Bill and Melinda Gates Foundation.

  4. Next-Generation Mitogenomics: A Comparison of Approaches Applied to Caecilian Amphibian Phylogeny

    OpenAIRE

    Maddock, Simon T.; Briscoe, Andrew G.; Wilkinson, Mark; Waeschenbach, Andrea; San Mauro, Diego; Day, Julia J.; Littlewood, D. Tim J.; Foster, Peter G.; Nussbaum, Ronald A.; Gower, David J.

    2016-01-01

    Mitochondrial genome (mitogenome) sequences are being generated with increasing speed due to the advances of next-generation sequencing (NGS) technology and associated analytical tools. However, detailed comparisons to explore the utility of alternative NGS approaches applied to the same taxa have not been undertaken. We compared a ‘traditional’ Sanger sequencing method with two NGS approaches (shotgun sequencing and non-indexed, multiplex amplicon sequencing) on four different sequencing pla...

  5. Evaluation Metrics for Intermediate Heat Exchangers for Next Generation Nuclear Reactors

    International Nuclear Information System (INIS)

    Sabharwall, Piyush; Kim, Eung Soo; Anderson, Nolan

    2011-01-01

    The Department of Energy (DOE) is working with industry to develop a next generation, high-temperature gas-cooled reactor (HTGR) as a part of the effort to supply the United States with abundant, clean, and secure energy as initiated by the Energy Policy Act of 2005 (EPAct; Public Law 109-58,2005). The NGNP Project, led by the Idaho National Laboratory (INL), will demonstrate the ability of the HTGR to generate hydrogen, electricity, and/or high-quality process heat for a wide range of industrial applications.

  6. Astro Data Science: The Next Generation

    Science.gov (United States)

    Mentzel, Chris

    2018-01-01

    Astronomers have been at the forefront of data-driven discovery since before the days of Kepler. Using data in the scientific inquiry into the workings of the the universe is the lifeblood of the field. This said, data science is considered a new thing, and researchers from every discipline are rushing to learn data science techniques, train themselves on data science tools, and even leaving academia to become data scientists. It is undeniable that our ability to harness new computational and statistical methods to make sense of today’s unprecedented size, complexity, and fast streaming data is helping scientists make new discoveries. The question now is how to ensure that researchers can employ these tools and use them appropriately. This talk will cover the state of data science as it relates to scientific research and the role astronomers play in its development, use, and training the next generation of astro-data scientists.

  7. Next generation light robotic

    DEFF Research Database (Denmark)

    Villangca, Mark Jayson; Palima, Darwin; Banas, Andrew Rafael

    2017-01-01

    -assisted surgery imbibes surgeons with superhuman abilities and gives the expression “surgical precision” a whole new meaning. Still in its infancy, much remains to be done to improve human-robot collaboration both in realizing robots that can operate safely with humans and in training personnel that can work......Conventional robotics provides machines and robots that can replace and surpass human performance in repetitive, difficult, and even dangerous tasks at industrial assembly lines, hazardous environments, or even at remote planets. A new class of robotic systems no longer aims to replace humans...... with so-called automatons but, rather, to create robots that can work alongside human operators. These new robots are intended to collaborate with humans—extending their abilities—from assisting workers on the factory floor to rehabilitating patients in their homes. In medical robotics, robot...

  8. Mutation Detection in Patients with Retinal Dystrophies Using Targeted Next Generation Sequencing

    DEFF Research Database (Denmark)

    Weisschuh, Nicole; Mayer, Anja K; Strom, Tim M

    2016-01-01

    Retinal dystrophies (RD) constitute a group of blinding diseases that are characterized by clinical variability and pronounced genetic heterogeneity. The different nonsyndromic and syndromic forms of RD can be attributed to mutations in more than 200 genes. Consequently, next generation sequencing...

  9. A bibliometric analysis of the development of next generation active nanotechnologies

    International Nuclear Information System (INIS)

    Suominen, Arho; Li, Yin; Youtie, Jan; Shapira, Philip

    2016-01-01

    Delineating the emergence of nanotechnologies that offer new functionalities is an important element in an anticipatory approach to the governance of nanotechnology and its potential impacts. This paper examines the transition to next generation active nanotechnologies which incorporate functions that respond to the environment or systems concepts that combine devices and structures that are dynamic and which may change their states in use. We develop an approach to identifying these active nanotechnologies and then use bibliometric analysis to examine the extent of research papers and patents involving these concepts. We also examine references to environmental, health, and safety concepts in these papers, given that these next generation nanotechnologies are likely to have risk profiles that are different from those of first-generation passive nanomaterials. Our results show a steady growth overall in focus on active nanotechnologies in the research literature and in patents over the study period of 1990–2010. We also find an increase in consideration given to environmental, health, and safety topics. While gaps are highlighted in our understanding of research and innovation in active nanotechnologies, the results suggest that there is beginning to be a shift to active nanotechnologies, with the implication that governance processes need to be conscious of this shift and to prepare for it.

  10. A bibliometric analysis of the development of next generation active nanotechnologies

    Energy Technology Data Exchange (ETDEWEB)

    Suominen, Arho [VTT Technical Research Centre of Finland (Finland); Li, Yin; Youtie, Jan, E-mail: jan.youtie@innovate.gatech.edu; Shapira, Philip [Georgia Institute of Technology (United States)

    2016-09-15

    Delineating the emergence of nanotechnologies that offer new functionalities is an important element in an anticipatory approach to the governance of nanotechnology and its potential impacts. This paper examines the transition to next generation active nanotechnologies which incorporate functions that respond to the environment or systems concepts that combine devices and structures that are dynamic and which may change their states in use. We develop an approach to identifying these active nanotechnologies and then use bibliometric analysis to examine the extent of research papers and patents involving these concepts. We also examine references to environmental, health, and safety concepts in these papers, given that these next generation nanotechnologies are likely to have risk profiles that are different from those of first-generation passive nanomaterials. Our results show a steady growth overall in focus on active nanotechnologies in the research literature and in patents over the study period of 1990–2010. We also find an increase in consideration given to environmental, health, and safety topics. While gaps are highlighted in our understanding of research and innovation in active nanotechnologies, the results suggest that there is beginning to be a shift to active nanotechnologies, with the implication that governance processes need to be conscious of this shift and to prepare for it.

  11. Automotive Radar and Lidar Systems for Next Generation Driver Assistance Functions

    Directory of Open Access Journals (Sweden)

    R. H. Rasshofer

    2005-01-01

    Full Text Available Automotive radar and lidar sensors represent key components for next generation driver assistance functions (Jones, 2001. Today, their use is limited to comfort applications in premium segment vehicles although an evolution process towards more safety-oriented functions is taking place. Radar sensors available on the market today suffer from low angular resolution and poor target detection in medium ranges (30 to 60m over azimuth angles larger than ±30°. In contrast, Lidar sensors show large sensitivity towards environmental influences (e.g. snow, fog, dirt. Both sensor technologies today have a rather high cost level, forbidding their wide-spread usage on mass markets. A common approach to overcome individual sensor drawbacks is the employment of data fusion techniques (Bar-Shalom, 2001. Raw data fusion requires a common, standardized data interface to easily integrate a variety of asynchronous sensor data into a fusion network. Moreover, next generation sensors should be able to dynamically adopt to new situations and should have the ability to work in cooperative sensor environments. As vehicular function development today is being shifted more and more towards virtual prototyping, mathematical sensor models should be available. These models should take into account the sensor's functional principle as well as all typical measurement errors generated by the sensor.

  12. Detection of TET2 , KRAS and CBL variants by Next Generation ...

    African Journals Online (AJOL)

    Aim: In this study, we aimed to find possible genetic markers for molecular analysis in childhood AML by screening hot-spot exons of TET2, KRAS, and CBL using Next Generation Sequencing (NGS) analysis. In addition, association between found variants and mutations of Januse Kinase-2 (JAK2) and Fms Related ...

  13. Addressing Next Generation Science Standards: A Method for Supporting Classroom Teachers

    Science.gov (United States)

    Pellien, Tamara; Rothenburger, Lisa

    2014-01-01

    The Next Generation Science Standards (NGSS) will define science education for the foreseeable future, yet many educators struggle to see the bridge between current practice and future practices. The inquiry-based methods used by Extension professionals (Kress, 2006) can serve as a guide for classroom educators. Described herein is a method of…

  14. The next generation of Palapa satellite (Palapa-C)

    Science.gov (United States)

    Setiawan, Bambang

    The Indonesian Palapa Communication Satellite System was established in Aug. 1976 when the first satellite of Palapa A series (Palapa A1) began operation. The system is owned and operated by PT. Telekomunikasi Indonesia (Telkom), which is a state owned company. The purpose of the system was to unify the telecommunications of the nation. Many years of operation have shown that satellite technology is the best solution for improving telecommunications in Indonesia. The system was started with 2 (two) satellites, each with 12 transponders (for a total of 24), and 40 earth stations. Now the system has 3 (three) satellites, each with 24 transponders (for a total of 72 transponders), and thousands of earth stations. The services have been extended to satisfy the requirements of the region as well as the original objectives. The use of satellite transponders in the region is increasing rapidly. In the next ten years, opportunities in the satellite communications business will become even more attractive. The next generation Palapa-C will incorporate improvements in capacity, quality, and coverage. The new frequency bands (ku- and Extended-C Band) will be used to meet the new transponder capacity requirements.

  15. Next-generation approaches to the microbial ecology of food fermentations

    Directory of Open Access Journals (Sweden)

    Nicholas A. Bokulich1,2,3 & David A. Mills1,2,3*

    2012-07-01

    Full Text Available Food fermentations have enhanced human health since the dawnof time and remain a prevalent means of food processing andpreservation. Due to their cultural and nutritional importance,many of these foods have been studied in detail using moleculartools, leading to enhancements in quality and safety. Furthermore,recent advances in high-throughput sequencing technologyare revolutionizing the study of food microbial ecology,deepening insight into complex fermentation systems. Thisreview provides insight into novel applications of selectmolecular techniques, particularly next-generation sequencingtechnology, for analysis of microbial communities in fermentedfoods. We present a guideline for integrated molecular analysis offood microbial ecology and a starting point for implementingnext-generation analysis of food systems.

  16. Methodology on the sparger development for Korean next generation reactor

    International Nuclear Information System (INIS)

    Kim, Hwan Yeol; Hwang, Y.D.; Kang, H.S.; Cho, B.H.; Park, J.K.

    1999-06-01

    In case of an accident, the safety depressurization system of Korean Next Generation Reactor (KNGR) efficiently depressurize the reactor pressure by directly discharge steam of high pressure and temperature from the pressurizer into the in-containment refuelling water storage tank (IRWST) through spargers. This report was generated for the purpose of developing the sparger of KNGR. This report presents the methodology on application of ABB-Atom. Many thermal hydraulic parameters affecting the maximum bubble could pressure were obtained and the maximum bubble cloud pressure transient curve so called forcing function of KNGR was suggested and design inputs for IRWST (bubble cloud radius vs. time, bubble cloud velocity vs. time, bubble cloud acceleration vs. time, etc.) were generated by the analytic using Rayleigh-Plesset equation. (author). 17 refs., 6 tabs., 27 figs

  17. Methodology on the sparger development for Korean next generation reactor

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hwan Yeol; Hwang, Y.D.; Kang, H.S.; Cho, B.H.; Park, J.K

    1999-06-01

    In case of an accident, the safety depressurization system of Korean Next Generation Reactor (KNGR) efficiently depressurize the reactor pressure by directly discharge steam of high pressure and temperature from the pressurizer into the in-containment refuelling water storage tank (IRWST) through spargers. This report was generated for the purpose of developing the sparger of KNGR. This report presents the methodology on application of ABB-Atom. Many thermal hydraulic parameters affecting the maximum bubble could pressure were obtained and the maximum bubble cloud pressure transient curve so called forcing function of KNGR was suggested and design inputs for IRWST (bubble cloud radius vs. time, bubble cloud velocity vs. time, bubble cloudacceleration vs. time, etc.) were generated by the analytic using Rayleigh-Plesset equation. (author). 17 refs., 6 tabs., 27 figs.

  18. Interferometric detectors of gravitational waves on Earth: the next generations

    Energy Technology Data Exchange (ETDEWEB)

    Losurdo, G [INFN Firenze - Via G.Sansone 1, 50019 - Sesto F., Firenze (Italy)], E-mail: losurdo@fi.infn.it

    2008-05-15

    First generation long-baseline interferometric detectors of gravitational waves are now taking data. A first detection might be possible with these instruments, but more sensitive detectors will be needed to start the field of gravitational wave astronomy. Second generation interferometers will improve the sensitivity by a factor ten, allowing to explore a universe volume 1000 times larger. The technology is almost ready and the construction will start at the beginning of the next decade. The community of the physicists involved in the field has also started to make plans for third generation detectors, for which a long term technology development program will be required. The plans for the upgrades of the existing detectors and the scenario for the evolution of the field will be reviewed in this paper.

  19. The Next-Generation U.S. Retail Electricity Market with Customers and Prosumers—A Bibliographical Survey

    Directory of Open Access Journals (Sweden)

    Tao Chen

    2017-12-01

    Full Text Available Due to the rapidly-changing technologies in the power industry, many new references addressing the frameworks and business models of the next-generation retail electricity market are entering the research community. In particular, considering new customers with considerable demand response awareness and so-called prosumers with localized power generation based on distributed energy resources (DERs, the next-generation retail electricity market infrastructure will be a level playing field for local energy transactions, strategic pricing scheme design, new business model design and building an innovative energy ecosystem. Consequently, there is an urgent need to keep track of international experiences and activities taking place in the field of the market mechanism design problem at the distribution level. This paper provides a comprehensive survey of recent technology developments and aims to inspire awareness of the further deregulation of the electricity market, especially in areas close to customers. We mainly bring attention to the more than 90 articles published during the past five years. The collected literature has been divided into different sections to discuss different aspects of the next-generation retail electricity market under the deregulated power industry.

  20. Reducing Risk for the Next Generation Nuclear Plant

    Energy Technology Data Exchange (ETDEWEB)

    John M. Beck II; Harold J. Heydt; Emmanuel O. Opare; Kyle B. Oswald

    2010-07-01

    The Next Generation Nuclear Plant (NGNP) Project, managed by the Idaho National Laboratory (INL), is directed by the Energy Policy Act of 2005, to research, develop, design, construct, and operate a prototype forth generation nuclear reactor to meet the needs of the 21st Century. As with all large projects developing and deploying new technologies, the NGNP has numerous risks that need to be identified, tracked, mitigated, and reduced in order for successful project completion. A Risk Management Plan (RMP) was created to outline the process the INL is using to manage the risks and reduction strategies for the NGNP Project. Integral to the RMP is the development and use of a Risk Management System (RMS). The RMS is a tool that supports management and monitoring of the project risks. The RMS does not only contain a risk register, but other functionality that allows decision makers, engineering staff, and technology researchers to review and monitor the risks as the project matures.

  1. Modular EUV Source for the next generation lithography

    International Nuclear Information System (INIS)

    Sublemontier, O.; Rosset-Kos, M.; Ceccotti, T.; Hergott, J.F.; Auguste, Th.; Normand, D.; Schmidt, M.; Beaumont, F.; Farcage, D.; Cheymol, G.; Le Caro, J.M.; Cormont, Ph.; Mauchien, P.; Thro, P.Y.; Skrzypczak, J.; Muller, S.; Marquis, E.; Barthod, B.; Gaurand, I.; Davenet, M.; Bernard, R.

    2011-01-01

    The present work, performed in the frame of the EXULITE project, was dedicated to the design and characterization of a laser-plasma-produced extreme ultraviolet (EUV) source prototype at 13.5 nm for the next generation lithography. It was conducted in cooperation with two laboratories from CEA, ALCATEL and THALES. One of our approach originalities was the laser scheme modularity. Six Nd:YAG laser beams were focused at the same time on a xenon filament jet to generate the EUV emitting plasma. Multiplexing has important industrial advantages and led to interesting source performances in terms of in-band power, stability and angular emission properties with the filament jet target. A maximum conversion efficiency (CE) value of 0.44% in 2π sr and 2% bandwidth was measured, which corresponds to a maximum in band EUV mean power of 7.7 W at a repetition rate of 6 kHz. The EUV emission was found to be stable and isotropic in these conditions. (authors)

  2. Reducing Risk for the Next Generation Nuclear Plant

    International Nuclear Information System (INIS)

    Beck, John M. II; Heydt, Harold J.; Opare, Emmanuel O.; Oswald, Kyle B.

    2010-01-01

    The Next Generation Nuclear Plant (NGNP) Project, managed by the Idaho National Laboratory (INL), is directed by the Energy Policy Act of 2005, to research, develop, design, construct, and operate a prototype forth generation nuclear reactor to meet the needs of the 21st Century. As with all large projects developing and deploying new technologies, the NGNP has numerous risks that need to be identified, tracked, mitigated, and reduced in order for successful project completion. A Risk Management Plan (RMP) was created to outline the process the INL is using to manage the risks and reduction strategies for the NGNP Project. Integral to the RMP is the development and use of a Risk Management System (RMS). The RMS is a tool that supports management and monitoring of the project risks. The RMS does not only contain a risk register, but other functionality that allows decision makers, engineering staff, and technology researchers to review and monitor the risks as the project matures.

  3. Next generation reactor development activity at Hitachi, Ltd

    International Nuclear Information System (INIS)

    Yamashita, Junichi

    2005-01-01

    Developments of innovative nuclear systems in Japan have been highly requested to cope with uncertain future nuclear power generation and fuel cycle situation. Next generation reactor system shall be surely deployed earlier to be capable to provide with several options such as plutonium multi-recycle, intermediate storage of spent fuels, simplified reprocessing of spent fuels and separated storage of 'Pu+FP' and 'U', spent fuels storage after Pu LWR recycle and their combinations, while future reactor system will be targeted at ideal fuel recycle system of higher breeding gain and transmutation of radioactive wastes. Modified designs of the ABWR at large size and medium and small size have been investigated as well as a BWR based RMWR and a supercritical-pressure LWR to ensure safety and improve economics. Advanced fuel cycle technologies of a combination of fluoride volatility process and PUREX process with high decontamination (FLUOREX process) and a modified fluoride volatility process with low decontamination have been developed. (T. Tanaka)

  4. NIRS report of investigations for the development of the next generation PET apparatus. FY 2002

    International Nuclear Information System (INIS)

    2003-03-01

    The present status of studies conducted by representative technology fields for the development of the next generation PET apparatus, and the summary of opinions given by investigators of nuclear medicine are reported. The former involves chapters of: Summary of representative technologies for the development of the next generation PET apparatus; Count rate analysis of PET apparatuses for the whole body and small animals by PET simulator; Scintillator; DOI (depth of interaction) detector-evaluation of the detector with 256-ch fluorescence polarization-photomultiplier tubes (FP-PMT) trial apparatus etc; Examination of multi-slice DOI-MR compatible detector for PET; Development of application specific integrated circuit (ASIC) for processing the front-end signals; Detector simulation; Circuit for processing PET detector signals; Signal processing-coincidence circuit; Data collection system; Signal processing technology for the next generation PET; Reconstruction of statistical PET image using DOI signals; Monte Carlo simulation and Unique directions-PET for infants and for the whole body autonomic nervous systems and mental activity; and Actual design and evaluation of image reconstruction by statistical means. Opinions are: Progress of clinical PET apparatus; Desirable PET drugs and apparatuses; From clinical practice for the development of the next generation PET apparatus; From clinical psychiatric studies for the development; From application of drug development and basic researches; From brain PET practice; From clinical PET practice; and The role of National Institute of Radiological Sciences (NIRS) in PET development. Also involved is the publication list. (N.I.)

  5. Next Generation Computer Resources: Reference Model for Project Support Environments (Version 2.0)

    National Research Council Canada - National Science Library

    Brown, Alan

    1993-01-01

    The objective of the Next Generation Computer Resources (NGCR) program is to restructure the Navy's approach to acquisition of standard computing resources to take better advantage of commercial advances and investments...

  6. Design of a fault diagnosis system for next generation nuclear power plants

    International Nuclear Information System (INIS)

    Zhao, K.; Upadhyaya, B.R.; Wood, R.T.

    2004-01-01

    A new design approach for fault diagnosis is developed for next generation nuclear power plants. In the nuclear reactor design phase, data reconciliation is used as an efficient tool to determine the measurement requirements to achieve the specified goal of fault diagnosis. In the reactor operation phase, the plant measurements are collected to estimate uncertain model parameters so that a high fidelity model can be obtained for fault diagnosis. The proposed algorithm of fault detection and isolation is able to combine the strength of first principle model based fault diagnosis and the historical data based fault diagnosis. Principal component analysis on the reconciled data is used to develop a statistical model for fault detection. The updating of the principal component model based on the most recent reconciled data is a locally linearized model around the current plant measurements, so that it is applicable to any generic nonlinear systems. The sensor fault diagnosis and process fault diagnosis are decoupled through considering the process fault diagnosis as a parameter estimation problem. The developed approach has been applied to the IRIS helical coil steam generator system to monitor the operational performance of individual steam generators. This approach is general enough to design fault diagnosis systems for the next generation nuclear power plants. (authors)

  7. Probing Extragalactic Planets Using Quasar Microlensing

    Science.gov (United States)

    Dai, Xinyu; Guerras, Eduardo

    2018-02-01

    Previously, planets have been detected only in the Milky Way galaxy. Here, we show that quasar microlensing provides a means to probe extragalactic planets in the lens galaxy, by studying the microlensing properties of emission close to the event horizon of the supermassive black hole of the background quasar, using the current generation telescopes. We show that a population of unbound planets between stars with masses ranging from Moon to Jupiter masses is needed to explain the frequent Fe Kα line energy shifts observed in the gravitationally lensed quasar RXJ 1131–1231 at a lens redshift of z = 0.295 or 3.8 billion lt-yr away. We constrain the planet mass-fraction to be larger than 0.0001 of the halo mass, which is equivalent to 2000 objects ranging from Moon to Jupiter mass per main-sequence star.

  8. Composite Materials under Extreme Radiation and Temperature Environments of the Next Generation Nuclear Reactors

    International Nuclear Information System (INIS)

    Simos, N.

    2011-01-01

    In the nuclear energy renaissance, driven by fission reactor concepts utilizing very high temperatures and fast neutron spectra, materials with enhanced performance that exceeds are expected to play a central role. With the operating temperatures of the Generation III reactors bringing the classical reactor materials close to their performance limits there is an urgent need to develop and qualify new alloys and composites. Efforts have been focused on the intricate relations and the high demands placed on materials at the anticipated extreme states within the next generation fusion and fission reactors which combine high radiation fluxes, elevated temperatures and aggressive environments. While nuclear reactors have been in operation for several decades, the structural materials associated with the next generation options need to endure much higher temperatures (1200 C), higher neutron doses (tens of displacements per atom, dpa), and extremely corrosive environments, which are beyond the experience on materials accumulated to-date. The most important consideration is the performance and reliability of structural materials for both in-core and out-of-core functions. While there exists a great body of nuclear materials research and operating experience/performance from fission reactors where epithermal and thermal neutrons interact with materials and alter their physio-mechanical properties, a process that is well understood by now, there are no operating or even experimental facilities that will facilitate the extreme conditions of flux and temperature anticipated and thus provide insights into the behaviour of these well understood materials. Materials, however, still need to be developed and their interaction and damage potential or lifetime to be quantified for the next generation nuclear energy. Based on material development advances, composites, and in particular ceramic composites, seem to inherently possess properties suitable for key functions within the

  9. Technology Innovations from NASA's Next Generation Launch Technology Program

    Science.gov (United States)

    Cook, Stephen A.; Morris, Charles E. K., Jr.; Tyson, Richard W.

    2004-01-01

    NASA's Next Generation Launch Technology Program has been on the cutting edge of technology, improving the safety, affordability, and reliability of future space-launch-transportation systems. The array of projects focused on propulsion, airframe, and other vehicle systems. Achievements range from building miniature fuel/oxygen sensors to hot-firings of major rocket-engine systems as well as extreme thermo-mechanical testing of large-scale structures. Results to date have significantly advanced technology readiness for future space-launch systems using either airbreathing or rocket propulsion.

  10. Application of photonics in next generation telecommunication satellites payloads

    Science.gov (United States)

    Anzalchi, J.; Inigo, P.; Roy, B.

    2017-11-01

    Next generation broadband telecommunication satellites are required to provide very high data throughput using complex multibeam architectures. These high throughput `Terabit/s' Satellites will incorporate payloads with very large quantity of conventional RF equipment, co-axial cables, waveguides, harnesses and ancillary equipment, making the Assembly, Integration and Test (AIT) very complex. Use of `RF over Fiber' and associated photonics equipment can make the process of AIT much simpler with the added benefit of significant reduction in number of payload equipment and inherent payload mass.

  11. AN UNDERSTANDING OF THE SHOULDER OF GIANTS: JOVIAN PLANETS AROUND LATE K DWARF STARS AND THE TREND WITH STELLAR MASS

    Energy Technology Data Exchange (ETDEWEB)

    Gaidos, Eric [Department of Geology and Geophysics, University of Hawai' i at Manoa, Honolulu, HI 96822 (United States); Fischer, Debra A. [Department of Astronomy, Yale University, New Haven, CT 06520 (United States); Mann, Andrew W.; Howard, Andrew W., E-mail: gaidos@hawaii.edu [Institute for Astronomy, University of Hawai' i at Manoa, Honolulu, HI 96822 (United States)

    2013-07-01

    Analyses of exoplanet statistics suggest a trend of giant planet occurrence with host star mass, a clue to how planets like Jupiter form. One missing piece of the puzzle is the occurrence around late K dwarf stars (masses of 0.5-0.75 M{sub Sun} and effective temperatures of 3900-4800 K). We analyzed four years of Doppler radial velocity (RVs) data for 110 late K dwarfs, one of which hosts two previously reported giant planets. We estimate that 4.0% {+-} 2.3% of these stars have Saturn-mass or larger planets with orbital periods <245 days, depending on the planet mass distribution and RV variability of stars without giant planets. We also estimate that 0.7% {+-} 0.5% of similar stars observed by Kepler have giant planets. This Kepler rate is significantly (99% confidence) lower than that derived from our Doppler survey, but the difference vanishes if only the single Doppler system (HIP 57274) with completely resolved orbits is considered. The difference could also be explained by the exclusion of close binaries (without giant planets) from the Doppler but not Kepler surveys, the effect of long-period companions and stellar noise on the Doppler data, or an intrinsic difference between the two populations. Our estimates for late K dwarfs bridge those for solar-type stars and M dwarfs, and support a positive trend with stellar mass. Small sample size precludes statements about finer structure, e.g., a ''shoulder'' in the distribution of giant planets with stellar mass. Future surveys such as the Next Generation Transit Survey and the Transiting Exoplanet Satellite Survey will ameliorate this deficiency.

  12. AN UNDERSTANDING OF THE SHOULDER OF GIANTS: JOVIAN PLANETS AROUND LATE K DWARF STARS AND THE TREND WITH STELLAR MASS

    International Nuclear Information System (INIS)

    Gaidos, Eric; Fischer, Debra A.; Mann, Andrew W.; Howard, Andrew W.

    2013-01-01

    Analyses of exoplanet statistics suggest a trend of giant planet occurrence with host star mass, a clue to how planets like Jupiter form. One missing piece of the puzzle is the occurrence around late K dwarf stars (masses of 0.5-0.75 M ☉ and effective temperatures of 3900-4800 K). We analyzed four years of Doppler radial velocity (RVs) data for 110 late K dwarfs, one of which hosts two previously reported giant planets. We estimate that 4.0% ± 2.3% of these stars have Saturn-mass or larger planets with orbital periods <245 days, depending on the planet mass distribution and RV variability of stars without giant planets. We also estimate that 0.7% ± 0.5% of similar stars observed by Kepler have giant planets. This Kepler rate is significantly (99% confidence) lower than that derived from our Doppler survey, but the difference vanishes if only the single Doppler system (HIP 57274) with completely resolved orbits is considered. The difference could also be explained by the exclusion of close binaries (without giant planets) from the Doppler but not Kepler surveys, the effect of long-period companions and stellar noise on the Doppler data, or an intrinsic difference between the two populations. Our estimates for late K dwarfs bridge those for solar-type stars and M dwarfs, and support a positive trend with stellar mass. Small sample size precludes statements about finer structure, e.g., a ''shoulder'' in the distribution of giant planets with stellar mass. Future surveys such as the Next Generation Transit Survey and the Transiting Exoplanet Satellite Survey will ameliorate this deficiency.

  13. Precision Controlled Carbon Materials for Next-Generation Optoelectronic and Photonic Devices

    Science.gov (United States)

    2018-01-08

    engineer next-generation carbon-based optoelectronic and photonic devices with superior performance and capabilities. These devices include carbon...electronics; (4) nanostructured graphene plasmonics; and (5) polymer-nanotube conjugate chemistry . (1) Semiconducting carbon nanotube-based...applications (In Preparation, 2018). (5) Polymer-nanotube conjugate chemistry Conjugated polymers can be exploited as agents for selectively wrapping and

  14. Compliance uncertainty of diameter characteristic in the next-generation geometrical product specifications and verification

    International Nuclear Information System (INIS)

    Lu, W L; Jiang, X; Liu, X J; Xu, Z G

    2008-01-01

    Compliance uncertainty is one of the most important elements in the next-generation geometrical product specifications and verification (GPS). It consists of specification uncertainty, method uncertainty and implementation uncertainty, which are three of the four fundamental uncertainties in the next-generation GPS. This paper analyzes the key factors that influence compliance uncertainty and then proposes a procedure to manage the compliance uncertainty. A general model on evaluation of compliance uncertainty has been devised and a specific formula for diameter characteristic has been derived based on this general model. The case study was conducted and it revealed that the completeness of currently dominant diameter characteristic specification needs to be improved

  15. Next generation platforms for high-throughput bio-dosimetry

    International Nuclear Information System (INIS)

    Repin, Mikhail; Turner, Helen C.; Garty, Guy; Brenner, David J.

    2014-01-01

    Here the general concept of the combined use of plates and tubes in racks compatible with the American National Standards Institute/the Society for Laboratory Automation and Screening microplate formats as the next generation platforms for increasing the throughput of bio-dosimetry assays was described. These platforms can be used at different stages of bio-dosimetry assays starting from blood collection into micro-tubes organised in standardised racks and ending with the cytogenetic analysis of samples in standardised multi-well and multichannel plates. Robotically friendly platforms can be used for different bio-dosimetry assays in minimally equipped laboratories and on cost-effective automated universal biotech systems. (authors)

  16. Traffic Management for Next Generation Transport Networks

    DEFF Research Database (Denmark)

    Yu, Hao

    required by the next generation transport network to provide Quality-of-Service (QoS) guaranteed video services. Augmenting network capacity and upgrading network nodes indicate long deployment period, replacement of equipment and thus significant cost to the network service providers. This challenge may...... slacken the steps of some network operators towards providing IPTV services. In this dissertation, the topology-based hierarchical scheduling scheme is proposed to tackle the problem addressed. The scheme simplifies the deployment process by placing an intelligent switch with centralized traffic...... management functions at the edge of the network, scheduling traffic on behalf of the other nodes. The topology-based hierarchical scheduling scheme is able to provide outstanding flow isolation due to its centralized scheduling ability, which is essential for providing IPTV services. In order to reduce...

  17. Envisioning the Next Generation of Behavioral Health and Criminal Justice Interventions

    Science.gov (United States)

    Epperson, Matthew W.; Wolff, Nancy; Morgan, Robert D.; Fisher, William H.; Frueh, B. Christopher; Huening, Jessica

    2014-01-01

    The purpose of this paper is to cast a vision for the next generation of behavioral health and criminal justice interventions for persons with serious mental illnesses in the criminal justice system. The limitations of first generation interventions, including their primary focus on mental health treatment connection, are discussed. A person-place framework for understanding the complex factors that contribute to criminal justice involvement for this population is presented. We discuss practice and research recommendations for building more effective interventions to address both criminal justice and mental health outcomes. PMID:24666731

  18. Next-Generation Library Catalogs and the Problem of Slow Response Time

    Directory of Open Access Journals (Sweden)

    Margaret Brown-Sica

    2010-12-01

    Full Text Available Response time as defined for this study is the time that it takes for all files that constitute a single webpage to travel across the Internet from a Web server to the end user’s browser. In this study, the authors tested response times on queries for identical items in five different library catalogs, one of them a next-generation (NextGen catalog. The authors also discuss acceptable response time and how it may affect the discovery process. They suggest that librarians and vendors should develop standards for acceptable response time and use it in the product selection and development processes.

  19. Tracing the Baryon Cycle within Nearby Galaxies with a next-generation VLA

    Science.gov (United States)

    Kepley, Amanda A.; Leroy, Adam; Murphy, Eric J.; ngVLA Baryon Cycle Science Working Group

    2017-01-01

    The evolution of galaxies over cosmic time is shaped by the cycling of baryons through these systems, namely the inflow of atomic gas, the formation of molecular structures, the birth of stars, and the expulsion of gas due to associated feedback processes. The best way to study this cycle in detail are observations of nearby galaxies. These systems provide a complete picture of baryon cycling over a wide range of astrophysical conditions. In the next decade, higher resolution/sensitivity observations of such galaxies will fundamentally improve our knowledge of galaxy formation and evolution, allowing us to better interpret higher redshift observations of sources that were rapidly evolving at epochs soon after the Big Bang. In particular, the centimeter-to-millimeter part of the spectrum provides critical diagnostics for each of the key baryon cycling processes and access to almost all phases of gas in galaxies: cool and cold gas (via emission and absorption lines), ionized gas (via free-free continuum and recombination lines), cosmic rays and hot gas (via synchrotron emission and the Sunyaev-Zeldovich effect). This poster highlights a number of key science problems in this area whose solutions require a next-generation radio-mm interferometer such as the next-generation VLA.

  20. Challenges and opportunities in estimating viral genetic diversity from next-generation sequencing data

    Directory of Open Access Journals (Sweden)

    Niko eBeerenwinkel

    2012-09-01

    Full Text Available Many viruses, including the clinically relevant RNA viruses HIV and HCV, exist in large populations and display high genetic heterogeneity within and between infected hosts. Assessing intra-patient viral genetic diversity is essential for understanding the evolutionary dynamics of viruses, for designing effective vaccines, and for the success of antiviral therapy. Next-generation sequencing technologies allow the rapid and cost-effective acquisition of thousands to millions of short DNA sequences from a single sample. However, this approach entails several challenges in experimental design and computational data analysis. Here, we review the entire process of inferring viral diversity from sample collection to computing measures of genetic diversity. We discuss sample preparation, including reverse transcription and amplification, and the effect of experimental conditions on diversity estimates due to in vitro base substitutions, insertions, deletions, and recombination. The use of different next-generation sequencing platforms and their sequencing error profiles are compared in the context of various applications of diversity estimation, ranging from the detection of single nucleotide variants to the reconstruction of whole-genome haplotypes. We describe the statistical and computational challenges arising from these technical artifacts, and we review existing approaches, including available software, for their solution. Finally, we discuss open problems, and highlight successful biomedical applications and potential future clinical use of next-generation sequencing to estimate viral diversity.

  1. Next-Generation Sequencing and Genome Editing in Plant Virology

    Directory of Open Access Journals (Sweden)

    Ahmed Hadidi

    2016-08-01

    Full Text Available Next-generation sequencing (NGS has been applied to plant virology since 2009. NGS provides highly efficient, rapid, low cost DNA or RNA high-throughput sequencing of the genomes of plant viruses and viroids and of the specific small RNAs generated during the infection process. These small RNAs, which cover frequently the whole genome of the infectious agent, are 21-24 nt long and are known as vsRNAs for viruses and vd-sRNAs for viroids. NGS has been used in a number of studies in plant virology including, but not limited to, discovery of novel viruses and viroids as well as detection and identification of those pathogens already known, analysis of genome diversity and evolution, and study of pathogen epidemiology. The genome engineering editing method, clustered regularly interspaced short palindromic repeats (CRISPR-Cas9 system has been successfully used recently to engineer resistance to DNA geminiviruses (family, Geminiviridae by targeting different viral genome sequences in infected Nicotiana benthamiana or Arabidopsis plants. The DNA viruses targeted include tomato yellow leaf curl virus and merremia mosaic virus (begomovirus; beet curly top virus and beet severe curly top virus (curtovirus; and bean yellow dwarf virus (mastrevirus. The technique has also been used against the RNA viruses zucchini yellow mosaic virus, papaya ringspot virus and turnip mosaic virus (potyvirus and cucumber vein yellowing virus (ipomovirus, family, Potyviridae by targeting the translation initiation genes eIF4E in cucumber or Arabidopsis plants. From these recent advances of major importance, it is expected that NGS and CRISPR-Cas technologies will play a significant role in the very near future in advancing the field of plant virology and connecting it with other related fields of biology.Keywords: Next-generation sequencing, NGS, plant virology, plant viruses, viroids, resistance to plant viruses by CRISPR-Cas9

  2. Characterizing Cool Giant Planets in Reflected Light

    Science.gov (United States)

    Marley, Mark

    2016-01-01

    While the James Webb Space Telescope will detect and characterize extrasolar planets by transit and direct imaging, a new generation of telescopes will be required to detect and characterize extrasolar planets by reflected light imaging. NASA's WFIRST space telescope, now in development, will image dozens of cool giant planets at optical wavelengths and will obtain spectra for several of the best and brightest targets. This mission will pave the way for the detection and characterization of terrestrial planets by the planned LUVOIR or HabEx space telescopes. In my presentation I will discuss the challenges that arise in the interpretation of direct imaging data and present the results of our group's effort to develop methods for maximizing the science yield from these planned missions.

  3. Dynamic Planet Mercury in the Context of Its Environment

    CERN Document Server

    Clark, Pamela Elizabeth

    2007-01-01

    We are in a time of transition in our understanding of Mercury. Of particular interest here is the emerging picture of the planet as a system, with interactions between interior, surface, exosphere, and magnetosphere that have influenced and constrained the evolution of each part of the system. Previous books have emphasized the results of Mariner 10 and current ground-based measurements, with very little discussion of the nature and influence of the magnetosphere. This book will present the planet in the context of its surroundings, thus providing a foundation for the next major influx of information from Mercury and contributing to the planning for future missions.

  4. Preparing the Next Generation of Higher Education Faculty in Special Education

    Science.gov (United States)

    deBettencourt, Laurie U.

    2014-01-01

    There is a shortage in the number of funded doctoral programs in the field of special education. As a result the number of higher education faculty who are trained in the knowledge and skills necessary to train the next generation of special education teachers is critically low. This article describes a doctoral program funded by the Office of…

  5. THERMAL TIDES IN FLUID EXTRASOLAR PLANETS

    International Nuclear Information System (INIS)

    Arras, Phil; Socrates, Aristotle

    2010-01-01

    Asynchronous rotation and orbital eccentricity lead to time-dependent irradiation of the close-in gas giant exoplanets-the hot Jupiters. This time-dependent surface heating gives rise to fluid motions which propagate throughout the planet. We investigate the ability of this 'thermal tide' to produce a quadrupole moment which can couple to the stellar gravitational tidal force. While previous investigations discussed planets with solid surfaces, here we focus on entirely fluid planets in order to understand gas giants with small cores. The Coriolis force, thermal diffusion, and self-gravity of the perturbations are ignored for simplicity. First, we examine the response to thermal forcing through analytic solutions of the fluid equations which treat the forcing frequency as a small parameter. In the 'equilibrium tide' limit of zero frequency, fluid motion is present but does not induce a quadrupole moment. In the next approximation, finite frequency corrections to the equilibrium tide do lead to a nonzero quadrupole moment, the sign of which torques the planet away from synchronous spin. We then numerically solve the boundary value problem for the thermally forced, linear response of a planet with neutrally stratified interior and a stably stratified envelope. The numerical results find quadrupole moments in agreement with the analytic non-resonant result at a sufficiently long forcing period. Surprisingly, in the range of forcing periods of 1-30 days, the induced quadrupole moments can be far larger than the analytic result due to response of internal gravity waves which propagate in the radiative envelope. We discuss the relevance of our results for the spin, eccentricity, and thermal evolution of hot Jupiters.

  6. Wireless next generation networks a virtue-based trust model

    CERN Document Server

    Harvey, Melissa

    2014-01-01

    This SpringerBrief proposes a trust model motivated by virtue epistemology, addressing the need for a more efficient and flexible trust model for wireless next generation networks. This theory of trust simplifies the computation and communication overhead of strictly cognitive-computational models of trust. Both the advantages and the challenges of virtue-based trust models are discussed. This brief offers new research and a general theory of rationality that enables users to interpret trust and reason as complementary mechanisms that guide our rational conduct at two different epistemic level

  7. Use of next-generation sequencing in oral cavity cancer

    DEFF Research Database (Denmark)

    Tabatabaeifar, Siavosh; Kruse, Torben A; Thomassen, Mads

    Background: Oral cavity cancer is a subgroup of head and neck cancer which is the world’s 6th most common cancer form. Oral squamous cell carcinomas (OSCC) constitute almost all oral cavity cancers, and OSCC are primarily attributed by excessive alcohol consumption and tobacco exposure...... of tumour cells exists. Conclusions: Use of next generation sequencing in oral cavity cancer can give valuable insight into the biology of the disease. By investigating intra tumour heterogeneity we see that the different tumour specimens in each patient are quite homogenous, but evidence of heterogeneous...

  8. lociNGS: a lightweight alternative for assessing suitability of next-generation loci for evolutionary analysis.

    Directory of Open Access Journals (Sweden)

    Sarah M Hird

    Full Text Available Genomic enrichment methods and next-generation sequencing produce uneven coverage for the portions of the genome (the loci they target; this information is essential for ascertaining the suitability of each locus for further analysis. lociNGS is a user-friendly accessory program that takes multi-FASTA formatted loci, next-generation sequence alignments and demographic data as input and collates, displays and outputs information about the data. Summary information includes the parameters coverage per locus, coverage per individual and number of polymorphic sites, among others. The program can output the raw sequences used to call loci from next-generation sequencing data. lociNGS also reformats subsets of loci in three commonly used formats for multi-locus phylogeographic and population genetics analyses - NEXUS, IMa2 and Migrate. lociNGS is available at https://github.com/SHird/lociNGS and is dependent on installation of MongoDB (freely available at http://www.mongodb.org/downloads. lociNGS is written in Python and is supported on MacOSX and Unix; it is distributed under a GNU General Public License.

  9. Performance analysis of next-generation lunar laser retroreflectors

    Science.gov (United States)

    Ciocci, Emanuele; Martini, Manuele; Contessa, Stefania; Porcelli, Luca; Mastrofini, Marco; Currie, Douglas; Delle Monache, Giovanni; Dell'Agnello, Simone

    2017-09-01

    Starting from 1969, Lunar Laser Ranging (LLR) to the Apollo and Lunokhod Cube Corner Retroreflectors (CCRs) provided several tests of General Relativity (GR). When deployed, the Apollo/Lunokhod CCRs design contributed only a negligible fraction of the ranging error budget. Today the improvement over the years in the laser ground stations makes the lunar libration contribution relevant. So the libration now dominates the error budget limiting the precision of the experimental tests of gravitational theories. The MoonLIGHT-2 project (Moon Laser Instrumentation for General relativity High-accuracy Tests - Phase 2) is a next-generation LLR payload developed by the Satellite/lunar/GNSS laser ranging/altimetry and Cube/microsat Characterization Facilities Laboratory (SCF _ Lab) at the INFN-LNF in collaboration with the University of Maryland. With its unique design consisting of a single large CCR unaffected by librations, MoonLIGHT-2 can significantly reduce error contribution of the reflectors to the measurement of the lunar geodetic precession and other GR tests compared to Apollo/Lunokhod CCRs. This paper treats only this specific next-generation lunar laser retroreflector (MoonLIGHT-2) and it is by no means intended to address other contributions to the global LLR error budget. MoonLIGHT-2 is approved to be launched with the Moon Express 1(MEX-1) mission and will be deployed on the Moon surface in 2018. To validate/optimize MoonLIGHT-2, the SCF _ Lab is carrying out a unique experimental test called SCF-Test: the concurrent measurement of the optical Far Field Diffraction Pattern (FFDP) and the temperature distribution of the CCR under thermal conditions produced with a close-match solar simulator and simulated space environment. The focus of this paper is to describe the SCF _ Lab specialized characterization of the performance of our next-generation LLR payload. While this payload will improve the contribution of the error budget of the space segment (MoonLIGHT-2

  10. Next generation tools for genomic data generation, distribution, and visualization.

    Science.gov (United States)

    Nix, David A; Di Sera, Tonya L; Dalley, Brian K; Milash, Brett A; Cundick, Robert M; Quinn, Kevin S; Courdy, Samir J

    2010-09-09

    With the rapidly falling cost and availability of high throughput sequencing and microarray technologies, the bottleneck for effectively using genomic analysis in the laboratory and clinic is shifting to one of effectively managing, analyzing, and sharing genomic data. Here we present three open-source, platform independent, software tools for generating, analyzing, distributing, and visualizing genomic data. These include a next generation sequencing/microarray LIMS and analysis project center (GNomEx); an application for annotating and programmatically distributing genomic data using the community vetted DAS/2 data exchange protocol (GenoPub); and a standalone Java Swing application (GWrap) that makes cutting edge command line analysis tools available to those who prefer graphical user interfaces. Both GNomEx and GenoPub use the rich client Flex/Flash web browser interface to interact with Java classes and a relational database on a remote server. Both employ a public-private user-group security model enabling controlled distribution of patient and unpublished data alongside public resources. As such, they function as genomic data repositories that can be accessed manually or programmatically through DAS/2-enabled client applications such as the Integrated Genome Browser. These tools have gained wide use in our core facilities, research laboratories and clinics and are freely available for non-profit use. See http://sourceforge.net/projects/gnomex/, http://sourceforge.net/projects/genoviz/, and http://sourceforge.net/projects/useq.

  11. Providing a USSD location based clinic finder in South Africa: did it work?

    Science.gov (United States)

    Parsons, Annie Neo; Timler, Dagmar

    2014-01-01

    A new mHealth service, Clinic Finder, was designed to provide a location-based service for any cellphone user in South Africa dialing a dedicated USSD string to find the nearest public primary health care facility. The service was funded by a European Union grant to Cell-Life to support the National Department of Health. Clinic Finder's aims were to provide a reliable and accurate service, and to assess both the most effective means of advertising the service as well as interest in the service. Users dialing the USSD string are asked to agree to geo-location (Vodacom and MTN users) or asked to enter their province, town and street (virtual network users and those choosing not to geo-locate). The service provider, AAT, sends the data to Cell-Life where an SMS with details of the nearest public primary health care facility is sent to the user by Cell-Life's open-source Communicate platform. The service was advertised on 3 days in 2014 using two different means: a newspaper ad on 20 May 2014 and Please Call Me ads on 30 July 2014 and 14 August 2014. 28.2% of unique users on 20 May 2014, 10.5% of unique users on 30 July 2014 and 92.8% of unique users on 14 August 2014 who agreed to geo-location successfully received SMSs. However, only 4.2%, 0.5%, and 2.4% of unique users responding to each advertisement who did not geo-locate then received an SMS. A small survey of users following the 20 May 2014 newspaper ad found overall interest in the idea of Clinic Finder, though unsuccessful users were more likely to dislike the service. The overall experience of using location based services and USSD for Clinic Finder suggests a need in the field of mHealth for wider availability of data on service usability and effectiveness.

  12. The Relationship between Kolb's Learning Styles and StrengthsFinder's Talent Themes

    Science.gov (United States)

    Caldwell, Adonna B.

    2009-01-01

    The purpose of this study was to investigate if there were relationships between college students' talent themes as defined by the Clifton StrengthsFinder(TM) Instrument and their learning style as defined by Kolb Learning Styles Inventory. Logistical regression methodology was utilized to assess the relationship between learning styles and talent…

  13. Next-generation leadership development in family businesses: the critical roles of shared vision and family climate.

    Science.gov (United States)

    Miller, Stephen P

    2014-01-01

    The multigenerational survival rate for family-owned businesses is not good. Lack of a shared vision for the family enterprise and weak next-generation leadership are often cited as two of the leading reasons for the failure of family firms to successfully transition from one generation of family ownership to the next. The climate of the business-owning family has also been suggested as important to the performance of the family enterprise. Despite these commonly held tenets, there is a lack of rigorous quantitative research that explores the relationships among these three factors. To address this gap, a quantitative study of 100 next-generation family firm leaders and 350 family and non-family leaders and employees with whom they work was conducted. The results demonstrate that a shared vision for the family business has a strong effect on the leadership effectiveness of next-generation family leaders and a moderate effect on the degree to which they are positively engaged with their work. The findings also show that two dimensions of family climate significantly influence the likelihood that a shared vision for the family firm has been created. Open communication in the family is positively related to the presence of a shared vision for the business. Intergenerational authority, which refers to a senior generation that exercises unquestioned authority and sets the rules, is negatively related to the presence of a shared vision. Surprisingly, a third dimension of family climate, cognitive cohesion, which includes shared values in the family, had no relationship with the degree to which there was a shared vision for the family business. The implications for family business owners is that they would be wise to spend as much time on fostering a positive family climate characterized by open communication as they do on creating and executing a successful business strategy if their goal is to pass the business from one generation of family owners to the next.

  14. Next-generation leadership development in family businesses: the critical roles of shared vision and family climate

    Science.gov (United States)

    Miller, Stephen P.

    2014-01-01

    The multigenerational survival rate for family-owned businesses is not good. Lack of a shared vision for the family enterprise and weak next-generation leadership are often cited as two of the leading reasons for the failure of family firms to successfully transition from one generation of family ownership to the next. The climate of the business-owning family has also been suggested as important to the performance of the family enterprise. Despite these commonly held tenets, there is a lack of rigorous quantitative research that explores the relationships among these three factors. To address this gap, a quantitative study of 100 next-generation family firm leaders and 350 family and non-family leaders and employees with whom they work was conducted. The results demonstrate that a shared vision for the family business has a strong effect on the leadership effectiveness of next-generation family leaders and a moderate effect on the degree to which they are positively engaged with their work. The findings also show that two dimensions of family climate significantly influence the likelihood that a shared vision for the family firm has been created. Open communication in the family is positively related to the presence of a shared vision for the business. Intergenerational authority, which refers to a senior generation that exercises unquestioned authority and sets the rules, is negatively related to the presence of a shared vision. Surprisingly, a third dimension of family climate, cognitive cohesion, which includes shared values in the family, had no relationship with the degree to which there was a shared vision for the family business. The implications for family business owners is that they would be wise to spend as much time on fostering a positive family climate characterized by open communication as they do on creating and executing a successful business strategy if their goal is to pass the business from one generation of family owners to the next. PMID

  15. Next-Generation Leadership Development in Family Businesses: The Critical Roles of Shared Vision and Family Climate

    Directory of Open Access Journals (Sweden)

    Stephen Phillip Miller

    2014-12-01

    Full Text Available The multigenerational survival rate for family-owned businesses is not good. Lack of a shared vision for the family enterprise and weak next-generation leadership are often cited as two of the leading reasons for the failure of family firms to successfully transition from one generation of family ownership to the next. The climate of the business-owning family has also been suggested as important to the performance of the family enterprise. Despite these commonly held tenets, there is a lack of rigorous quantitative research that explores the relationships among these three factors. To address this gap, a quantitative study of 100 next-generation family firm leaders and 350 family and non-family leaders and employees with whom they work was conducted. The results demonstrate that a shared vision for the family business has a strong effect on the leadership effectiveness of next-generation family leaders and a moderate effect on the degree to which they are positively engaged with their work. The findings also show that two dimensions of family climate significantly influence the likelihood that a shared vision for the family firm has been created. Open communication in the family is positively related to the presence of a shared vision for the business. Intergenerational authority, which refers to a senior generation that exercises unquestioned authority and sets the rules, is negatively related to the presence of a shared vision. Surprisingly, a third dimension of family climate, cognitive cohesion, which includes shared values in the family, had no relationship with the degree to which there was a shared vision for the family business. The implications for family business owners is that they would be wise to spend as much time on fostering a positive family climate characterized by open communication as they do on creating and executing a successful business strategy if their goal is to pass the business from one generation of family owners to

  16. Detecting tree-like multicellular life on extrasolar planets.

    Science.gov (United States)

    Doughty, Christopher E; Wolf, Adam

    2010-11-01

    Over the next two decades, NASA and ESA are planning a series of space-based observatories to find Earth-like planets and determine whether life exists on these planets. Previous studies have assessed the likelihood of detecting life through signs of biogenic gases in the atmosphere or a red edge. Biogenic gases and the red edge could be signs of either single-celled or multicellular life. In this study, we propose a technique with which to determine whether tree-like multicellular life exists on extrasolar planets. For multicellular photosynthetic organisms on Earth, competition for light and the need to transport water and nutrients has led to a tree-like body plan characterized by hierarchical branching networks. This design results in a distinct bidirectional reflectance distribution function (BRDF) that causes differing reflectance at different sun/view geometries. BRDF arises from the changing visibility of the shadows cast by objects, and the presence of tree-like structures is clearly distinguishable from flat ground with the same reflectance spectrum. We examined whether the BRDF could detect the existence of tree-like structures on an extrasolar planet by using changes in planetary albedo as a planet orbits its star. We used a semi-empirical BRDF model to simulate vegetation reflectance at different planetary phase angles and both simulated and real cloud cover to calculate disk and rotation-averaged planetary albedo for a vegetated and non-vegetated planet with abundant liquid water. We found that even if the entire planetary albedo were rendered to a single pixel, the rate of increase of albedo as a planet approaches full illumination would be comparatively greater on a vegetated planet than on a non-vegetated planet. Depending on how accurately planetary cloud cover can be resolved and the capabilities of the coronagraph to resolve exoplanets, this technique could theoretically detect tree-like multicellular life on exoplanets in 50 stellar systems.

  17. Advanced optical components for next-generation photonic networks

    Science.gov (United States)

    Yoo, S. J. B.

    2003-08-01

    Future networks will require very high throughput, carrying dominantly data-centric traffic. The role of Photonic Networks employing all-optical systems will become increasingly important in providing scalable bandwidth, agile reconfigurability, and low-power consumptions in the future. In particular, the self-similar nature of data traffic indicates that packet switching and burst switching will be beneficial in the Next Generation Photonic Networks. While the natural conclusion is to pursue Photonic Packet Switching and Photonic Burst Switching systems, there are significant challenges in realizing such a system due to practical limitations in optical component technologies. Lack of a viable all-optical memory technology will continue to drive us towards exploring rapid reconfigurability in the wavelength domain. We will introduce and discuss the advanced optical component technologies behind the Photonic Packet Routing system designed and demonstrated at UC Davis. The system is capable of packet switching and burst switching, as well as circuit switching with 600 psec switching speed and scalability to 42 petabit/sec aggregated switching capacity. By utilizing a combination of rapidly tunable wavelength conversion and a uniform-loss cyclic frequency (ULCF) arrayed waveguide grating router (AWGR), the system is capable of rapidly switching the packets in wavelength, time, and space domains. The label swapping module inside the Photonic Packet Routing system containing a Mach-Zehnder wavelength converter and a narrow-band fiber Bragg-grating achieves all-optical label swapping with optical 2R (potentially 3R) regeneration while maintaining optical transparency for the data payload. By utilizing the advanced optical component technologies, the Photonic Packet Routing system successfully demonstrated error-free, cascaded, multi-hop photonic packet switching and routing with optical-label swapping. This paper will review the advanced optical component technologies

  18. Next-generation leadership development in family businesses: the critical roles of shared vision and family climate

    OpenAIRE

    Miller, Stephen P.

    2014-01-01

    The multigenerational survival rate for family-owned businesses is not good. Lack of a shared vision for the family enterprise and weak next-generation leadership are often cited as two of the leading reasons for the failure of family firms to successfully transition from one generation of family ownership to the next. The climate of the business-owning family has also been suggested as important to the performance of the family enterprise. Despite these commonly held tenets, there is a la...

  19. Integrated control of next generation power system

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2010-02-28

    The multi-agent system (MAS) approach has been applied with promising results for enhancing an electric power distribution circuit, such as the Circuit of the Future as developed by Southern California Edison. These next generation power system results include better ability to reconfigure the circuit as well as the increased capability to improve the protection and enhance the reliability of the circuit. There were four main tasks in this project. The specific results for each of these four tasks and their related topics are presented in main sections of this report. Also, there were seven deliverables for this project. The main conclusions for these deliverables are summarized in the identified subtask section of this report. The specific details for each of these deliverables are included in the “Project Deliverables” section at the end of this Final Report.

  20. NREL-Prime Next-Generation Drivetrain Dynamometer Test Report

    Energy Technology Data Exchange (ETDEWEB)

    Keller, Jonathan [National Renewable Energy Lab. (NREL), Golden, CO (United States); Erdman, Bill [Cinch, Inc., Moraga, CA (United States); Blodgett, Douglas [DNV KEMA Renewables, Burlington, VT (United States); Halse, Christopher [Romax Technology, Boulder, CO (United States)

    2016-08-01

    Advances in wind turbine drivetrain technologies are necessary to improve reliability and reduce the cost of energy for land-based and offshore wind turbines. The NREL-Prime Next-Generation Drivetrain team developed a geared, medium-speed drivetrain that is lighter, more reliable and more efficient than existing designs. One of the objectives of Phase II of the project was to complete the detailed design, fabrication, and dynamometer testing of a 750 kilowatt (kW) drivetrain that includes the key gearbox innovations designed by Romax Technology and power converter innovations designed by DNV Kema Renewables. The purpose of this document is to summarize these tests completed in NREL's National Wind Technology Center 2.5 megawatt (MW) dynamometer.

  1. Next Generation Driver for Attosecond and Laser-plasma Physics.

    Science.gov (United States)

    Rivas, D E; Borot, A; Cardenas, D E; Marcus, G; Gu, X; Herrmann, D; Xu, J; Tan, J; Kormin, D; Ma, G; Dallari, W; Tsakiris, G D; Földes, I B; Chou, S-W; Weidman, M; Bergues, B; Wittmann, T; Schröder, H; Tzallas, P; Charalambidis, D; Razskazovskaya, O; Pervak, V; Krausz, F; Veisz, L

    2017-07-12

    The observation and manipulation of electron dynamics in matter call for attosecond light pulses, routinely available from high-order harmonic generation driven by few-femtosecond lasers. However, the energy limitation of these lasers supports only weak sources and correspondingly linear attosecond studies. Here we report on an optical parametric synthesizer designed for nonlinear attosecond optics and relativistic laser-plasma physics. This synthesizer uniquely combines ultra-relativistic focused intensities of about 10 20  W/cm 2 with a pulse duration of sub-two carrier-wave cycles. The coherent combination of two sequentially amplified and complementary spectral ranges yields sub-5-fs pulses with multi-TW peak power. The application of this source allows the generation of a broad spectral continuum at 100-eV photon energy in gases as well as high-order harmonics in relativistic plasmas. Unprecedented spatio-temporal confinement of light now permits the investigation of electric-field-driven electron phenomena in the relativistic regime and ultimately the rise of next-generation intense isolated attosecond sources.

  2. Next Generation Science Standards: A National Mixed-Methods Study on Teacher Readiness

    Science.gov (United States)

    Haag, Susan; Megowan, Colleen

    2015-01-01

    Next Generation Science Standards (NGSS) science and engineering practices are ways of eliciting the reasoning and applying foundational ideas in science. As research has revealed barriers to states and schools adopting the NGSS, this mixed-methods study attempts to identify characteristics of professional development (PD) that will support NGSS…

  3. Planning Instruction to Meet the Intent of the Next Generation Science Standards

    Science.gov (United States)

    Krajcik, Joseph; Codere, Susan; Dahsah, Chanyah; Bayer, Renee; Mun, Kongju

    2014-03-01

    The National Research Council's Framework for K- 12 Science Education and the Next Generation Science Standards (NGSS Lead States in Next Generation Science Standards: For states, by states. The National Academies Press, Washington, 2013) move teaching away from covering many isolated facts to a focus on a smaller number of disciplinary core ideas (DCIs) and crosscutting concepts that can be used to explain phenomena and solve problems by engaging in science and engineering practices. The NGSS present standards as knowledge-in-use by expressing them as performance expectations (PEs) that integrate all three dimensions from the Framework for K- 12 Science Education. This integration of core ideas, practices, and crosscutting concepts is referred to as three-dimensional learning (NRC in Division of Behavioral and Social Sciences and Education. The National Academies Press, Washington, 2014). PEs state what students can be assessed on at the end of grade level for K-5 and at the end of grade band for 6-8 and 9-12. PEs do not specify how instruction should be developed nor do they serve as objectives for individual lessons. To support students in developing proficiency in the PEs, the elements of the DCIs will need to be blended with various practices and crosscutting concepts. In this paper, we examine how to design instruction to support students in meeting a cluster or "bundle" of PEs and how to blend the three dimensions to develop lesson level PEs that can be used for guiding instruction. We provide a ten-step process and an example of that process that teachers and curriculum designers can use to design lessons that meet the intent of the Next Generation of Science Standards.

  4. Optimizing the TESS Planet Finding Pipeline

    Science.gov (United States)

    Chitamitara, Aerbwong; Smith, Jeffrey C.; Tenenbaum, Peter; TESS Science Processing Operations Center

    2017-10-01

    The Transiting Exoplanet Survey Satellite (TESS) is a new NASA planet finding all-sky survey that will observe stars within 200 light years and 10-100 times brighter than that of the highly successful Kepler mission. TESS is expected to detect ~1000 planets smaller than Neptune and dozens of Earth size planets. As in the Kepler mission, the Science Processing Operations Center (SPOC) processing pipeline at NASA Ames Research center is tasked with calibrating the raw pixel data, generating systematic error corrected light curves and then detecting and validating transit signals. The Transiting Planet Search (TPS) component of the pipeline must be modified and tuned for the new data characteristics in TESS. For example, due to each sector being viewed for as little as 28 days, the pipeline will be identifying transiting planets based on a minimum of two transit signals rather than three, as in the Kepler mission. This may result in a significantly higher false positive rate. The study presented here is to measure the detection efficiency of the TESS pipeline using simulated data. Transiting planets identified by TPS are compared to transiting planets from the simulated transit model using the measured epochs, periods, transit durations and the expected detection statistic of injected transit signals (expected MES). From the comparisons, the recovery and false positive rates of TPS is measured. Measurements of recovery in TPS are then used to adjust TPS configuration parameters to maximize the planet recovery rate and minimize false detections. The improvements in recovery rate between initial TPS conditions and after various adjustments will be presented and discussed.

  5. Searching for life with the Terrestrial Planet Finder: Lagrange point options for a formation flying interferometer

    Science.gov (United States)

    Beichman, C.; Gomez, G.; Lo, M.; Masdemont, J.; Romans, L.

    2002-01-01

    In this paper, we describe the mission design for TPF assuming a distributed spacecraft concept using formation flight around both a halo orbit around L2 as well as a heliocentric orbit. Although the mission architecture is still under study, the next two years will include study of four design cncepts and a downselect to two concepts around 2005.

  6. Next Generation Germanium Systems for Safeguards Applications

    International Nuclear Information System (INIS)

    Dreyer, J.; Burks, M.; Hull, E.

    2015-01-01

    We are developing the latest generation of highly portable, mechanically cooled germanium systems for safeguard applications. In collaboration with our industrial partner, Ph.D.s Co, we have developed the Germanium Gamma Ray Imager (GeGI), an imager with a 2π field of view. This instrument has been thoroughly field tested in a wide range of environments and have performed reliably even in the harshest conditions. The imaging capability of GeGI complements existing safeguards techniques by allowing for the spatial detection, identification, and characterization of nuclear material. Additionally, imaging can be used in design information verification activities to address potential material diversions. Measurements conducted at the Paducah Gaseous Diffusion Plant highlight the advantages this instrument offers in the identification and localization of LEU, HEU and Pu holdup. GeGI has also been deployed to the Savannah River Site for the measurement of radioactive waste canisters, providing information valuable for waste characterization and inventory accountancy. Measuring 30 x 15 x 23 cm and weighing approximately 15 kg, this instrument is the first portable germanium-based imager. GeGI offers high reliability with the convenience of mechanical cooling, making this instrument ideal for the next generation of safeguards instrumentation. (author)

  7. Wireless and wireline service convergence in next generation optical access networks - the FP7 WISCON project

    DEFF Research Database (Denmark)

    Vegas Olmos, Juan José; Pang, Xiaodan; Lebedev, Alexander

    2014-01-01

    The next generation of information technology demands both high capacity and mobility for applications such as high speed wireless access capable of supporting broadband services. The transport of wireless and wireline signals is converging into a common telecommunication infrastructure....... In this paper, we will present the Marie Curie Framework Program 7 project “Wireless and wireline service convergence in next generation optical access networks” (WISCON), which focuses on the conception and study of novel architectures for wavelength-division-multiplexing (WDM) optical multi-modulation format...

  8. Next-generation nozzle check valve significantly reduces operating costs

    Energy Technology Data Exchange (ETDEWEB)

    Roorda, O. [SMX International, Toronto, ON (Canada)

    2009-01-15

    Check valves perform an important function in preventing reverse flow and protecting plant and mechanical equipment. However, the variety of different types of valves and extreme differences in performance even within one type can change maintenance requirements and life cycle costs, amounting to millions of dollars over the typical 15-year design life of piping components. A next-generation non-slam nozzle check valve which prevents return flow has greatly reduced operating costs by protecting the mechanical equipment in a piping system. This article described the check valve varieties such as the swing check valve, a dual-plate check valve, and nozzle check valves. Advancements in optimized design of a non-slam nozzle check valve were also discussed, with particular reference to computer flow modelling such as computational fluid dynamics; computer stress modelling such as finite element analysis; and flow testing (using rapid prototype development and flow loop testing), both to improve dynamic performance and reduce hydraulic losses. The benefits of maximized dynamic performance and minimized pressure loss from the new designed valve were also outlined. It was concluded that this latest non-slam nozzle check valve design has potential applications in natural gas, liquefied natural gas, and oil pipelines, including subsea applications, as well as refineries, and petrochemical plants among others, and is suitable for horizontal and vertical installation. The result of this next-generation nozzle check valve design is not only superior performance, and effective protection of mechanical equipment but also minimized life cycle costs. 1 fig.

  9. A Framework for the Next Generation of Risk Science

    Science.gov (United States)

    Krewski, Daniel; Andersen, Melvin E.; Paoli, Gregory M.; Chiu, Weihsueh A.; Al-Zoughool, Mustafa; Croteau, Maxine C.; Burgoon, Lyle D.; Cote, Ila

    2014-01-01

    Objectives: In 2011, the U.S. Environmental Protection Agency initiated the NexGen project to develop a new paradigm for the next generation of risk science. Methods: The NexGen framework was built on three cornerstones: the availability of new data on toxicity pathways made possible by fundamental advances in basic biology and toxicological science, the incorporation of a population health perspective that recognizes that most adverse health outcomes involve multiple determinants, and a renewed focus on new risk assessment methodologies designed to better inform risk management decision making. Results: The NexGen framework has three phases. Phase I (objectives) focuses on problem formulation and scoping, taking into account the risk context and the range of available risk management decision-making options. Phase II (risk assessment) seeks to identify critical toxicity pathway perturbations using new toxicity testing tools and technologies, and to better characterize risks and uncertainties using advanced risk assessment methodologies. Phase III (risk management) involves the development of evidence-based population health risk management strategies of a regulatory, economic, advisory, community-based, or technological nature, using sound principles of risk management decision making. Conclusions: Analysis of a series of case study prototypes indicated that many aspects of the NexGen framework are already beginning to be adopted in practice. Citation: Krewski D, Westphal M, Andersen ME, Paoli GM, Chiu WA, Al-Zoughool M, Croteau MC, Burgoon LD, Cote I. 2014. A framework for the next generation of risk science. Environ Health Perspect 122:796–805; http://dx.doi.org/10.1289/ehp.1307260 PMID:24727499

  10. New Dimensions of Research on Actinomycetes: Quest for Next Generation Antibiotics

    Directory of Open Access Journals (Sweden)

    Polpass Arul Jose

    2016-08-01

    Full Text Available Starting with the discovery of streptomycin, the promise of natural products research on actinomycetes has been captivat¬ing researchers and offered an array of life-saving antibiotics. However, most of the actinomycetes have received a little attention of researchers beyond isolation and activity screening. Noticeable gaps in genomic information and associated biosynthetic potential of actinomycetes are mainly the reasons for this situation, which has led to a decline in the discovery rate of novel antibiotics. Recent insights gained from genome mining have revealed a massive existence of previously unrecognized biosynthetic potential in actinomycetes. Successive developments in next-generation sequencing, genome editing, analytical separation and high-resolution spectroscopic methods have reinvigorated interest on such actinomycetes and opened new avenues for the discovery of natural and natural-inspired antibiotics. This article describes the new dimensions that have driven the ongoing resurgence of research on actinomycetes with historical background since the commencement in 1940, for the attention of worldwide researchers. Coupled with increasing advancement in molecular and analytical tools and techniques, the discovery of next-generation antibiotics could be possible by revisiting the untapped potential of actinomycetes from different natural sources.

  11. Universal Intelligent Small Cell (UnISCell for next generation cellular networks

    Directory of Open Access Journals (Sweden)

    Mohammad Patwary

    2016-11-01

    Full Text Available Exploring innovative cellular architectures to achieve enhanced system capacity and good coverage has become a critical issue towards realizing the next generation of wireless communications. In this context, this paper proposes a novel concept of Universal Intelligent Small Cell (UnISCell for enabling the densification of the next generation of cellular networks. The proposed novel concept envisions an integrated platform of providing a strong linkage between different stakeholders such as street lighting networks, landline telephone networks and future wireless networks, and is universal in nature being independent of the operating frequency bands and traffic types. The main motivating factors for the proposed small cell concept are the need of public infrastructure re-engineering, and the recent advances in several enabling technologies. First, we highlight the main concepts of the proposed UnISCell platform. Subsequently, we present two deployment scenarios for the proposed UnISCell concept considering infrastructure sharing and service sharing as important aspects. We then describe the key future technologies for enabling the proposed UnISCell concept and present a use case example with the help of numerical results. Finally, we conclude this article by providing some interesting future recommendations.

  12. Evaluation of next generation biomass derived fuels for the transport sector

    International Nuclear Information System (INIS)

    Tsita, Katerina G.; Pilavachi, Petros A.

    2013-01-01

    This paper evaluates next generation biomass derived fuels for the transport sector, employing the Analytic Hierarchy Process. Eight different alternatives of fuels are considered in this paper: bio-hydrogen, bio-synthetic natural gas, bio-dimethyl ether, bio-methanol, hydro thermal upgrading diesel, bio-ethanol, algal biofuel and electricity from biomass incineration. The evaluation of alternative fuels is performed according to various criteria that include economic, technical, social and policy aspects. In order to evaluate each alternative fuel, one base scenario and five alternative scenarios with different weight factors selection per criterion are presented. After deciding the alternative fuels’ scoring against each criterion and the criteria weights, their synthesis gives the overall score and ranking for all alternative scenarios. It is concluded that synthetic natural gas and electricity from biomass incineration are the most suitable next generation biomass derived fuels for the transport sector. -- Highlights: •Eight alternative fuels for the transport sector have been evaluated. •The method of the AHP was used. •The evaluation is performed according to economic, technical, social and policy criteria. •Bio-SNG and electricity from biomass incineration are the most suitable fuels

  13. MAP Science for Use with Next Generation Science Standards. NWEA External FAQ

    Science.gov (United States)

    Northwest Evaluation Association, 2016

    2016-01-01

    Measures of Academic Progress® (MAP®) Science for use with Next Generation Science Standards (NGSS) assessments are available for the 2016-17 school year. These new assessments measure student growth toward understanding of the multidimensional NGSS performance expectations. This report presents MAP Science for use with NGSS by presenting and…

  14. Next Generation Parallelization Systems for Processing and Control of PDS Image Node Assets

    Science.gov (United States)

    Verma, R.

    2017-06-01

    We present next-generation parallelization tools to help Planetary Data System (PDS) Imaging Node (IMG) better monitor, process, and control changes to nearly 650 million file assets and over a dozen machines on which they are referenced or stored.

  15. Worlds beyond our own the search for habitable planets

    CERN Document Server

    Sengupta, Sujan

    2015-01-01

    This is a book on planets: Solar system planets and dwarf planets. And planets outside our solar system – exoplanets. How did they form? What types of planets are there and what do they have in common? How do they differ? What do we know about their atmospheres – if they have one? What are the conditions for life and on which planets may they be met? And what’s the origin of life on Earth and how did it form? You will understand how rare the solar system, the Earth and hence life is. This is also a book on stars. The first and second generation of stars in the Universe. But in particular also on the link between planets and stars – brown dwarfs. Their atmospheric properties and similarities with giant exoplanets. All these fascinating questions will be answered in a non-technical manner. But those of you who want to know a bit more may look up the relevant mathematical relationships in appendices.

  16. Next Generation Wind Turbine

    Energy Technology Data Exchange (ETDEWEB)

    Cheraghi, S. Hossein [Western New England Univ., Springfield, MA (United States); Madden, Frank [FloDesign Wind Turbine Corp., Waltham, MA (United States)

    2012-09-01

    The goal of this collaborative effort between Western New England University's College of Engineering and FloDesign Wind Turbine (FDWT) Corporation to wok on a novel areodynamic concept that could potentially lead to the next generation of wind turbines. Analytical studies and early scale model tests of FDWT's Mixer/Ejector Wind Turbine (MEWT) concept, which exploits jet-age advanced fluid dynamics, indicate that the concept has the potential to significantly reduce the cost of electricity over conventional Horizontal Axis Wind Turbines while reducing land usage. This project involved the design, fabrication, and wind tunnel testing of components of MEWT to provide the research and engineering data necessary to validate the design iterations and optimize system performance. Based on these tests, a scale model prototype called Briza was designed, fabricated, installed and tested on a portable tower to investigate and improve the design system in real world conditions. The results of these scale prototype efforts were very promising and have contributed significantly to FDWT's ongoing development of a product scale wind turbine for deployment in multiple locations around the U.S. This research was mutually beneficial to Western New England University, FDWT, and the DOE by utilizing over 30 student interns and a number of faculty in all efforts. It brought real-world wind turbine experience into the classroom to further enhance the Green Engineering Program at WNEU. It also provided on-the-job training to many students, improving their future employment opportunities, while also providing valuable information to further advance FDWT's mixer-ejector wind turbine technology, creating opportunities for future project innovation and job creation.

  17. A National Demonstration Project Building the Next Generation

    International Nuclear Information System (INIS)

    Keuter, Dan; Hughey, Kenneth; Melancon, Steve; Quinn, Edward 'Ted'

    2002-01-01

    The U.S., and the world to a greater extent, needs more electrical power generating plants. In the U.S. alone some estimates say that over the next 20 years more than 400,000 MWe of new generation will be needed. This in a period when domestic oil and gas production decreases while consumption increases. Consequently, the U.S. grows more and more dependent on foreign energy sources today importing approximately 60% of our needs. Consider also that the U.S., once the world leader in all nuclear technology, no long leads the world in this technology and each day that goes by the U.S. nuclear infrastructure becomes less and less robust. Due to its improved safety, reliability/economics and emission free generation nuclear power is once more seen as an important energy source in many countries. In 2000, the number of operating nuclear power plants worldwide increased to 438, with 36 new plants under construction. Unfortunately, no new reactor orders have been placed in the US since 1979. When one considers national issues such as reducing environmental emissions, reallocation and conservation of limited natural resources and domestic energy security, the need for new nuclear generation is essential. While the hurdles facing the deployment of new nuclear generation in the U.S. are certainly formidable, the consequences of inaction in this regard are intolerable. In partnership with industry, the Department of Energy should move forward with an aggressive effort in support of deployment of an advanced nuclear power reactor incorporating state-of-the-art safety and proliferation resistant systems. This effort should be structured so as to significantly advance the timetable by which the systems would be available for commercial deployment by taking advantage of ongoing efforts currently underway at DOE and industry. The effort should be sequenced, to the extent possible, so that it can best reflect, both with respect to schedule and capability, the evolving national

  18. Engineering Micromechanical Systems for the Next Generation Wireless Capsule Endoscopy

    Directory of Open Access Journals (Sweden)

    Stephen Woods

    2015-01-01

    Full Text Available Wireless capsule endoscopy (WCE enables the detection and diagnosis of inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis. However treatment of these pathologies can only be achieved through conventional means. This paper describes the next generation WCE with increased functionality to enable targeted drug delivery in the small intestinal tract. A prototype microrobot fabricated in Nylon 6 is presented which is capable of resisting peristaltic pressure through the deployment of an integrated holding mechanism and delivering targeted therapy. The holding action is achieved by extending an “anchor” spanning a 60.4 mm circumference, for an 11.0 mm diameter WCE. This function is achieved by a mechanism that occupies only 347.0 mm3 volume, including mechanics and actuator. A micropositioning mechanism is described which utilises a single micromotor to radially position and then deploy a needle 1.5 mm outside the microrobot’s body to deliver a 1 mL dose of medication to a targeted site. An analysis of the mechanics required to drive the holding mechanism is presented and an overview of microactuators and the state of the art in WCE is discussed. It is envisaged that this novel functionality will empower the next generation of WCE to help diagnose and treat pathologies of the GI tract.

  19. Engineering Micromechanical Systems for the Next Generation Wireless Capsule Endoscopy

    Science.gov (United States)

    Woods, Stephen; Constandinou, Timothy

    2015-01-01

    Wireless capsule endoscopy (WCE) enables the detection and diagnosis of inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. However treatment of these pathologies can only be achieved through conventional means. This paper describes the next generation WCE with increased functionality to enable targeted drug delivery in the small intestinal tract. A prototype microrobot fabricated in Nylon 6 is presented which is capable of resisting peristaltic pressure through the deployment of an integrated holding mechanism and delivering targeted therapy. The holding action is achieved by extending an “anchor” spanning a 60.4 mm circumference, for an 11.0 mm diameter WCE. This function is achieved by a mechanism that occupies only 347.0 mm3 volume, including mechanics and actuator. A micropositioning mechanism is described which utilises a single micromotor to radially position and then deploy a needle 1.5 mm outside the microrobot's body to deliver a 1 mL dose of medication to a targeted site. An analysis of the mechanics required to drive the holding mechanism is presented and an overview of microactuators and the state of the art in WCE is discussed. It is envisaged that this novel functionality will empower the next generation of WCE to help diagnose and treat pathologies of the GI tract. PMID:26258143

  20. Two-Dimensional Metal Oxide Nanomaterials for Next-Generation Rechargeable Batteries.

    Science.gov (United States)

    Mei, Jun; Liao, Ting; Kou, Liangzhi; Sun, Ziqi

    2017-12-01

    The exponential increase in research focused on two-dimensional (2D) metal oxides has offered an unprecedented opportunity for their use in energy conversion and storage devices, especially for promising next-generation rechargeable batteries, such as lithium-ion batteries (LIBs) and sodium-ion batteries (NIBs), as well as some post-lithium batteries, including lithium-sulfur batteries, lithium-air batteries, etc. The introduction of well-designed 2D metal oxide nanomaterials into next-generation rechargeable batteries has significantly enhanced the performance of these energy-storage devices by providing higher chemically active interfaces, shortened ion-diffusion lengths, and improved in-plane carrier-/charge-transport kinetics, which have greatly promoted the development of nanotechnology and the practical application of rechargeable batteries. Here, the recent progress in the application of 2D metal oxide nanomaterials in a series of rechargeable LIBs, NIBs, and other post lithium-ion batteries is reviewed relatively comprehensively. Current opportunities and future challenges for the application of 2D nanomaterials in energy-storage devices to achieve high energy density, high power density, stable cyclability, etc. are summarized and outlined. It is believed that the integration of 2D metal oxide nanomaterials in these clean energy devices offers great opportunities to address challenges driven by increasing global energy demands. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Areva's water chemistry guidebook with chemistry guidelines for next generation plants (AREVA EPRTM reactors)

    International Nuclear Information System (INIS)

    Ryckelynck, N.; Chahma, F.; Caris, N.; Guillermier, P.; Brun, C.; Caron-Charles, M.; Lamanna, L.; Fandrich, J.; Jaeggy, M.; Stellwag, B.

    2012-09-01

    Over the years, AREVA globally has maintained a strong expertise in LWR water chemistry and has been focused on minimizing short-term and long-term detrimental effects of chemistry for startup, operation and shutdown chemistry for all key plant components (material integrity and reliability, promote optimal thermal performances, etc.) and fuel. Also AREVA is focused on minimizing contamination and equipment/plant dose rates. Current Industry Guidelines (EPRI, VGB, etc.) provide utilities with selected chemistry guidance for the current operating fleet. With the next generation of PWR plants (e.g. AREVA's EPR TM reactor), materials of construction and design have been optimized based on industry lessons learned over the last 50+ years. To support the next generation design, AREVA water chemistry experts, have subsequently developed a Chemistry Guidebook with chemistry guidelines based on an analysis of the current international practices, plant operating experience, R and D data and calculation codes now available and/or developed by AREVA. The AREVA LWR chemistry Guidebook can be used to help resolve utility and safety authority questions and addresses regulation requirement questions/issues for next generation plants. The Chemistry Guidebook provides water chemistry guidelines for primary coolant, secondary side circuit and auxiliary systems during startup, normal operation and shutdown conditions. It also includes conditioning and impurity limits, along with monitoring locations and frequency requirements. The Chemistry Guidebook Guidelines will be used as a design reference for AREVA's next generation plants (e.g. EPR TM reactor). (authors)

  2. Next-generation sequencing in schizophrenia and other neuropsychiatric disorders.

    Science.gov (United States)

    Schreiber, Matthew; Dorschner, Michael; Tsuang, Debby

    2013-10-01

    Schizophrenia is a debilitating lifelong illness that lacks a cure and poses a worldwide public health burden. The disease is characterized by a heterogeneous clinical and genetic presentation that complicates research efforts to identify causative genetic variations. This review examines the potential of current findings in schizophrenia and in other related neuropsychiatric disorders for application in next-generation technologies, particularly whole-exome sequencing (WES) and whole-genome sequencing (WGS). These approaches may lead to the discovery of underlying genetic factors for schizophrenia and may thereby identify and target novel therapeutic targets for this devastating disorder. © 2013 Wiley Periodicals, Inc.

  3. Droplet Digital™ PCR Next-Generation Sequencing Library QC Assay.

    Science.gov (United States)

    Heredia, Nicholas J

    2018-01-01

    Digital PCR is a valuable tool to quantify next-generation sequencing (NGS) libraries precisely and accurately. Accurately quantifying NGS libraries enable accurate loading of the libraries on to the sequencer and thus improve sequencing performance by reducing under and overloading error. Accurate quantification also benefits users by enabling uniform loading of indexed/barcoded libraries which in turn greatly improves sequencing uniformity of the indexed/barcoded samples. The advantages gained by employing the Droplet Digital PCR (ddPCR™) library QC assay includes the precise and accurate quantification in addition to size quality assessment, enabling users to QC their sequencing libraries with confidence.

  4. Novel nanostructures for next generation dye-sensitized solar cells

    KAUST Repository

    Tétreault, Nicolas

    2012-01-01

    Herein, we review our latest advancements in nanostructured photoanodes for next generation photovoltaics in general and dye-sensitized solar cells in particular. Bottom-up self-assembly techniques are developed to fabricate large-area 3D nanostructures that enable enhanced charge extraction and light harvesting through optical scattering or photonic crystal effects to improve photocurrent, photovoltage and fill factor. Using generalized techniques to fabricate specialized nanostructures enables specific optoelectronic and physical characteristics like conduction, charge extraction, injection, recombination and light harvesting but also helps improve mechanical flexibility and long-term stability in low cost materials. © 2012 The Royal Society of Chemistry.

  5. A Survey on Next-generation Power Grid Data Architecture

    Energy Technology Data Exchange (ETDEWEB)

    You, Shutang [University of Tennessee, Knoxville (UTK); Zhu, Dr. Lin [University of Tennessee (UT); Liu, Yong [ORNL; Liu, Yilu [ORNL; Shankar, Mallikarjun (Arjun) [ORNL; Robertson, Russell [Grid Protection Alliance; King Jr, Thomas J [ORNL

    2015-01-01

    The operation and control of power grids will increasingly rely on data. A high-speed, reliable, flexible and secure data architecture is the prerequisite of the next-generation power grid. This paper summarizes the challenges in collecting and utilizing power grid data, and then provides reference data architecture for future power grids. Based on the data architecture deployment, related research on data architecture is reviewed and summarized in several categories including data measurement/actuation, data transmission, data service layer, data utilization, as well as two cross-cutting issues, interoperability and cyber security. Research gaps and future work are also presented.

  6. Reprint of "Application of next generation sequencing in clinical microbiology and infection prevention"

    NARCIS (Netherlands)

    Deurenberg, Ruud H.; Bathoorn, Erik; Chlebowicz, Monika A.; Monge Gomes do Couto, Natacha; Ferdous, Mithila; Garcia-Cobos, Silvia; Kooistra-Smid, Anna M. D.; Raangs, Erwin C.; Rosema, Sigrid; Veloo, Alida C. M.; Zhou, Kai; Friedrich, Alexander W.; Rossen, John W. A.

    2017-01-01

    Current molecular diagnostics of human pathogens provide limited information that is often not sufficient for outbreak and transmission investigation. Next generation sequencing (NGS) determines the DNA sequence of a complete bacterial genome in a single sequence run, and from these data,

  7. Microbial production of next-generation stevia sweeteners.

    Science.gov (United States)

    Olsson, Kim; Carlsen, Simon; Semmler, Angelika; Simón, Ernesto; Mikkelsen, Michael Dalgaard; Møller, Birger Lindberg

    2016-12-07

    The glucosyltransferase UGT76G1 from Stevia rebaudiana is a chameleon enzyme in the targeted biosynthesis of the next-generation premium stevia sweeteners, rebaudioside D (Reb D) and rebaudioside M (Reb M). These steviol glucosides carry five and six glucose units, respectively, and have low sweetness thresholds, high maximum sweet intensities and exhibit a greatly reduced lingering bitter taste compared to stevioside and rebaudioside A, the most abundant steviol glucosides in the leaves of Stevia rebaudiana. In the metabolic glycosylation grid leading to production of Reb D and Reb M, UGT76G1 was found to catalyze eight different reactions all involving 1,3-glucosylation of steviol C 13 - and C 19 -bound glucoses. Four of these reactions lead to Reb D and Reb M while the other four result in formation of side-products unwanted for production. In this work, side-product formation was reduced by targeted optimization of UGT76G1 towards 1,3 glucosylation of steviol glucosides that are already 1,2-diglucosylated. The optimization of UGT76G1 was based on homology modelling, which enabled identification of key target amino acids present in the substrate-binding pocket. These residues were then subjected to site-saturation mutagenesis and a mutant library containing a total of 1748 UGT76G1 variants was screened for increased accumulation of Reb D or M, as well as for decreased accumulation of side-products. This screen was performed in a Saccharomyces cerevisiae strain expressing all enzymes in the rebaudioside biosynthesis pathway except for UGT76G1. Screening of the mutant library identified mutations with positive impact on the accumulation of Reb D and Reb M. The effect of the introduced mutations on other reactions in the metabolic grid was characterized. This screen made it possible to identify variants, such as UGT76G1 Thr146Gly and UGT76G1 His155Leu , which diminished accumulation of unwanted side-products and gave increased specific accumulation of the desired

  8. Population genomics of marine fishes: next generation prospects and challenges

    DEFF Research Database (Denmark)

    Hansen, Jakob Hemmer; Therkildsen, Nina Overgaard; Pujolar, J.M.

    2014-01-01

    Over the past few years, technological advances have facilitated giant leaps forward in our ability to generate genome-wide molecular data, offering exciting opportunities for gaining new insights into the ecology and evolution of species where genomic information is still limited. Marine fishes...... time scales, identifying genomic signatures associated with population divergence under gene flow, and determining the genetic basis of phenotypic traits. We also consider future challenges pertaining to the implementation of genome-wide coverage through next-generation sequencing and genotyping...... methods in marine fishes. Complications associated with fast decay of linkage disequilibrium, as expected for species with large effective population sizes, and the possibility that adaptation is associated with both soft selective sweeps and polygenic selection, leaving complex genomic signatures...

  9. PAN-DA and beyond: Data acquisition for the next generation experiments

    International Nuclear Information System (INIS)

    Pordes, R.; Anderson, J.; Berg, D.; Berman, E.; Brown, D.; Dorries, T.; Mackinnon, B.; Meadows, J.; Moore, C.; Nicinski, T.; Oleynik, G.; Petravick, D.; Rechenmacher, R.; Sergey, G.; Slimmer, D.; Streets, J.; Vittone, M.; Votava, M.; Wilcer, N.; White, V.

    1991-06-01

    We report on the status of the PAN-DA data acquisition system presented at the last Real Time Conference. Since that time, PAN-DA has been successfully used in the fixed target program at Fermilab. We also report on the plans and strategies for development of a new data acquisition system for the next generation of fixed target experiments at Fermilab. 10 refs., 3 figs

  10. ALMOST ALL OF KEPLER'S MULTIPLE-PLANET CANDIDATES ARE PLANETS

    International Nuclear Information System (INIS)

    Lissauer, Jack J.; Rowe, Jason F.; Bryson, Stephen T.; Howell, Steve B.; Jenkins, Jon M.; Kinemuchi, Karen; Koch, David G.; Marcy, Geoffrey W.; Adams, Elisabeth; Fressin, Francois; Geary, John; Holman, Matthew J.; Ragozzine, Darin; Buchhave, Lars A.; Ciardi, David R.; Cochran, William D.; Fabrycky, Daniel C.; Ford, Eric B.; Morehead, Robert C.; Gilliland, Ronald L.

    2012-01-01

    We present a statistical analysis that demonstrates that the overwhelming majority of Kepler candidate multiple transiting systems (multis) indeed represent true, physically associated transiting planets. Binary stars provide the primary source of false positives among Kepler planet candidates, implying that false positives should be nearly randomly distributed among Kepler targets. In contrast, true transiting planets would appear clustered around a smaller number of Kepler targets if detectable planets tend to come in systems and/or if the orbital planes of planets encircling the same star are correlated. There are more than one hundred times as many Kepler planet candidates in multi-candidate systems as would be predicted from a random distribution of candidates, implying that the vast majority are true planets. Most of these multis are multiple-planet systems orbiting the Kepler target star, but there are likely cases where (1) the planetary system orbits a fainter star, and the planets are thus significantly larger than has been estimated, or (2) the planets orbit different stars within a binary/multiple star system. We use the low overall false-positive rate among Kepler multis, together with analysis of Kepler spacecraft and ground-based data, to validate the closely packed Kepler-33 planetary system, which orbits a star that has evolved somewhat off of the main sequence. Kepler-33 hosts five transiting planets, with periods ranging from 5.67 to 41 days.

  11. Next Generation Life Support Project Status

    Science.gov (United States)

    Barta, Daniel J.; Chullen, Cinda; Vega, Leticia; Cox, Marlon R.; Aitchison, Lindsay T.; Lange, Kevin E.; Pensinger, Stuart J.; Meyer, Caitlin E.; Flynn, Michael; Jackson, W. Andrew; hide

    2014-01-01

    Next Generation Life Support (NGLS) is one of over twenty technology development projects sponsored by NASA's Game Changing Development Program. The NGLS Project develops selected life support technologies needed for humans to live and work productively in space, with focus on technologies for future use in spacecraft cabin and space suit applications. Over the last three years, NGLS had five main project elements: Variable Oxygen Regulator (VOR), Rapid Cycle Amine (RCA) swing bed, High Performance (HP) Extravehicular Activity (EVA) Glove, Alternative Water Processor (AWP) and Series-Bosch Carbon Dioxide Reduction. The RCA swing bed, VOR and HP EVA Glove tasks are directed at key technology needs for the Portable Life Support System (PLSS) and pressure garment for an Advanced Extravehicular Mobility Unit (EMU). Focus is on prototyping and integrated testing in cooperation with the Advanced Exploration Systems (AES) Advanced EVA Project. The HP EVA Glove Element, new this fiscal year, includes the generation of requirements and standards to guide development and evaluation of new glove designs. The AWP and Bosch efforts focus on regenerative technologies to further close spacecraft cabin atmosphere revitalization and water recovery loops and to meet technology maturation milestones defined in NASA's Space Technology Roadmaps. These activities are aimed at increasing affordability, reliability, and vehicle self-sufficiency while decreasing mass and mission cost, supporting a capability-driven architecture for extending human presence beyond low-Earth orbit, along a human path toward Mars. This paper provides a status of current technology development activities with a brief overview of future plans.

  12. Next generation tools for genomic data generation, distribution, and visualization

    Directory of Open Access Journals (Sweden)

    Nix David A

    2010-09-01

    Full Text Available Abstract Background With the rapidly falling cost and availability of high throughput sequencing and microarray technologies, the bottleneck for effectively using genomic analysis in the laboratory and clinic is shifting to one of effectively managing, analyzing, and sharing genomic data. Results Here we present three open-source, platform independent, software tools for generating, analyzing, distributing, and visualizing genomic data. These include a next generation sequencing/microarray LIMS and analysis project center (GNomEx; an application for annotating and programmatically distributing genomic data using the community vetted DAS/2 data exchange protocol (GenoPub; and a standalone Java Swing application (GWrap that makes cutting edge command line analysis tools available to those who prefer graphical user interfaces. Both GNomEx and GenoPub use the rich client Flex/Flash web browser interface to interact with Java classes and a relational database on a remote server. Both employ a public-private user-group security model enabling controlled distribution of patient and unpublished data alongside public resources. As such, they function as genomic data repositories that can be accessed manually or programmatically through DAS/2-enabled client applications such as the Integrated Genome Browser. Conclusions These tools have gained wide use in our core facilities, research laboratories and clinics and are freely available for non-profit use. See http://sourceforge.net/projects/gnomex/, http://sourceforge.net/projects/genoviz/, and http://sourceforge.net/projects/useq.

  13. Balancing Performance and Sustainability in Next-Generation PMR Technologies for OMC Structures

    Science.gov (United States)

    2016-05-26

    John J. La Scala , Benjamin G. Harvey, Giuseppe R. Palmese, William S. Eck, Joshua M. Sadler, Santosh K. Yadav 5d. PROJECT NUMBER 5e. TASK NUMBER...PERFORMANCE AND SUSTAINABILITY IN NEXT-GENERATION PMR TECHNOLOGIES FOR OMC STRUCTURES Gregory R. Yandek,1 Jason T. Lamb,2 John J. La Scala ,3 Benjamin G

  14. Sustainability, the Next Generation Science Standards, and the Education of Future Teachers

    Science.gov (United States)

    Egger, Anne E.; Kastens, Kim A.; Turrin, Margaret K.

    2017-01-01

    The Next Generation Science Standards (NGSS) emphasize how human activities affect the Earth and how Earth processes impact humans, placing the concept of sustainability within the Earth and Space Sciences. We ask: how prepared are future teachers to address sustainability and systems thinking as encoded in the NGSS? And how can geoscientists…

  15. Middleware for the next generation Grid infrastructure

    CERN Document Server

    Laure, E; Prelz, F; Beco, S; Fisher, S; Livny, M; Guy, L; Barroso, M; Buncic, P; Kunszt, Peter Z; Di Meglio, A; Aimar, A; Edlund, A; Groep, D; Pacini, F; Sgaravatto, M; Mulmo, O

    2005-01-01

    The aim of the EGEE (Enabling Grids for E-Science in Europe) project is to create a reliable and dependable European Grid infrastructure for e-Science. The objective of the EGEE Middleware Re-engineering and Integration Research Activity is to provide robust middleware components, deployable on several platforms and operating systems, corresponding to the core Grid services for resource access, data management, information collection, authentication & authorization, resource matchmaking and brokering, and monitoring and accounting. For achieving this objective, we developed an architecture and design of the next generation Grid middleware leveraging experiences and existing components essentially from AliEn, EDG, and VDT. The architecture follows the service breakdown developed by the LCG ARDA group. Our strategy is to do as little original development as possible but rather re-engineer and harden existing Grid services. The evolution of these middleware components towards a Service Oriented Architecture ...

  16. Next-generation TCAP hydrogen isotope separation process

    International Nuclear Information System (INIS)

    Heung, L. K.; Sessions, H. T.; Poore, A. S.; Jacobs, W. D.; Williams, C. S.

    2008-01-01

    A thermal cycling absorption process (TCAP) for hydrogen isotope separation has been in operation at Savannah River Site since 1994. The process uses a hot/cold nitrogen system to cycle the temperature of the separation column. The hot/cold nitrogen system requires the use of large compressors, heat exchanges, valves and piping that is bulky and maintenance intensive. A new compact thermal cycling (CTC) design has recently been developed. This new design uses liquid nitrogen tubes and electric heaters to heat and cool the column directly so that the bulky hot/cold nitrogen system can be eliminated. This CTC design is simple and is easy to implement, and will be the next generation TCAP system at SRS. A twelve-meter column has been fabricated and installed in the laboratory to demonstrate its performance. The design of the system and its test results to date is discussed. (authors)

  17. Microbial production of next-generation stevia sweeteners

    DEFF Research Database (Denmark)

    Olsson, Kim; Carlsen, Simon; Semmler, Angelika

    2016-01-01

    BACKGROUND: The glucosyltransferase UGT76G1 from Stevia rebaudiana is a chameleon enzyme in the targeted biosynthesis of the next-generation premium stevia sweeteners, rebaudioside D (Reb D) and rebaudioside M (Reb M). These steviol glucosides carry five and six glucose units, respectively......, and have low sweetness thresholds, high maximum sweet intensities and exhibit a greatly reduced lingering bitter taste compared to stevioside and rebaudioside A, the most abundant steviol glucosides in the leaves of Stevia rebaudiana. RESULTS: In the metabolic glycosylation grid leading to production....... This screen made it possible to identify variants, such as UGT76G1Thr146Gly and UGT76G1His155Leu, which diminished accumulation of unwanted side-products and gave increased specific accumulation of the desired Reb D or Reb M sweeteners. This improvement in a key enzyme of the Stevia sweetener biosynthesis...

  18. Next Generation Luminaire (NGL) Downlight Demonstration Project, Hilton Columbus Downtown

    Energy Technology Data Exchange (ETDEWEB)

    Davis, R. G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Perrin, T. E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2014-09-30

    At the Hilton Columbus Downtown hotel in Ohio, DOE's Better Buildings Alliance conducted a demonstration of Next Generation Luminaires-winning downlights installed in all guest rooms and suites prior to the hotel's 2012 opening. After a post-occupancy assessment, the LED downlights not only provided the aesthetic appearance and dimming functionality desired, but also provided 50% energy savings relative to a comparable CFL downlight and enabled the lighting power to be more than 20% below that allowed by code.

  19. Domestic and foreign trends in the prevalence of heart failure and the necessity of next-generation artificial hearts: a survey by the Working Group on Establishment of Assessment Guidelines for Next-Generation Artificial Heart Systems.

    Science.gov (United States)

    Tatsumi, Eisuke; Nakatani, Takeshi; Imachi, Kou; Umezu, Mitsuo; Kyo, Shun-Ei; Sase, Kazuhiro; Takatani, Setsuo; Matsuda, Hikaru

    2007-01-01

    A series of guidelines for development and assessment of next-generation medical devices has been drafted under an interagency collaborative project by the Ministry of Health, Labor and Welfare and the Ministry of Economy, Trade and Industry. The working group for assessment guidelines of next-generation artificial hearts reviewed the trend in the prevalence of heart failure and examined the potential usefulness of such devices in Japan and in other countries as a fundamental part of the process of establishing appropriate guidelines. At present, more than 23 million people suffer from heart failure in developed countries, including Japan. Although Japan currently has the lowest mortality from heart failure among those countries, the number of patients is gradually increasing as our lifestyle becomes more Westernized; the associated medical expenses are rapidly growing. The number of heart transplantations, however, is limited due to the overwhelming shortage of donor hearts, not only in Japan but worldwide. Meanwhile, clinical studies and surveys have revealed that the major causes of death in patients undergoing long-term use of ventricular assist devices (VADs) were infection, thrombosis, and mechanical failure, all of which are typical of VADs. It is therefore of urgent and universal necessity to develop next-generation artificial hearts that have excellent durability to provide at least 2 years of event-free operation with a superior quality of life and that can be used for destination therapy to save patients with irreversible heart failure. It is also very important to ensure that an environment that facilitates the development, testing, and approval evaluation processes of next-generation artificial hearts be established as soon as possible.

  20. Scalable Multicasting over Next-Generation Internet Design, Analysis and Applications

    CERN Document Server

    Tian, Xiaohua

    2013-01-01

    Next-generation Internet providers face high expectations, as contemporary users worldwide expect high-quality multimedia functionality in a landscape of ever-expanding network applications. This volume explores the critical research issue of turning today’s greatly enhanced hardware capacity to good use in designing a scalable multicast  protocol for supporting large-scale multimedia services. Linking new hardware to improved performance in the Internet’s next incarnation is a research hot-spot in the computer communications field.   The methodical presentation deals with the key questions in turn: from the mechanics of multicast protocols to current state-of-the-art designs, and from methods of theoretical analysis of these protocols to applying them in the ns2 network simulator, known for being hard to extend. The authors’ years of research in the field inform this thorough treatment, which covers details such as applying AOM (application-oriented multicast) protocol to IPTV provision and resolving...