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Sample records for newly developed laboratory

  1. A newly developed snack effective for enhancing bone volume

    Directory of Open Access Journals (Sweden)

    Hayashi Hidetaka

    2009-07-01

    Full Text Available Abstract Background The incidence of primary osteoporosis is higher in Japan than in USA and European countries. Recently, the importance of preventive medicine has been gradually recognized in the field of orthopaedic surgery with a concept that peak bone mass should be increased in childhood as much as possible for the prevention of osteoporosis. Under such background, we have developed a new bean snack with an aim to improve bone volume loss. In this study, we examined the effects of a newly developed snack on bone volume and density in osteoporosis model mice. Methods Orchiectomy (ORX and ovariectomy (OVX were performed for C57BL/6J mice of twelve-week-old (Jackson Laboratory, Bar Harbar, ME, USA were used in this experiment. We prepared and given three types of powder diet e.g.: normal calcium diet (NCD, Ca: 0.9%, Clea Japan Co., Tokyo, Japan, low calcium diet (LCD, Ca: 0.63%, Clea Japan Co., and special diet (SCD, Ca: 0.9%. Eighteen weeks after surgery, all the animals were sacrified and prepared for histomorphometric analysis to quantify bone density and bone mineral content. Results As a result of histomorphometric examination, SCD was revealed to enhance bone volume irrespective of age and sex. The bone density was increased significantly in osteoporosis model mice fed the newly developmental snack as compared with the control mice. The bone mineral content was also enhanced significantly. These phenomena were revealed in both sexes. Conclusion It is shown that the newly developed bean snack is highly effective for the improvement of bone volume loss irrespective of sex. We demonstrated that newly developmental snack supplements may be a useful preventive measure for Japanese whose bone mineral density values are less than the ideal condition.

  2. Development of mobile radiological assessment laboratory

    International Nuclear Information System (INIS)

    Pujari, R.N.; Saindane, Shashank S.; Jain, Amit; Parmar, Jayesh; Narsaiah, M.V.R.; Pote, M.B.; Murali, S.; Chaudhury, Probal

    2018-01-01

    During any emergency situations real-time radiation measurements and the fast analysis of the measured radiological data are of crucial importance. The newly developed mobile vehicle based laboratory known as 'Radiological Assessment Laboratory' (RAL) can be used for real time measurements in different radiation emergency scenarios, such as the release of radioactive materials from a radiological/nuclear incident, during search of an orphan source or during radioisotope transportation. RAL is equipped with several high sensitive detectors/systems such as NaI(Tl) gamma spectrometers, large size plastic scintillators and air-sampler, along with GPS and data transfer capability through GSM modem

  3. Complications Associated with Long-Term Disposition of Newly-Generated Transuranic Waste: A National Laboratory Perspective

    International Nuclear Information System (INIS)

    Orchard, B.J.; Harvego, L.A.; Carlson, T.L.; Grant, R.P.

    2009-01-01

    The Idaho National Laboratory (INL) is a multipurpose national laboratory delivering specialized science and engineering solutions for the U.S. Department of Energy (DOE). Sponsorship of INL was formally transferred to the DOE Office of Nuclear Energy, Science and Technology (NE) by Secretary Spencer Abraham in July 2002. The move to NE, and designation as the DOE lead nuclear energy laboratory for reactor technology, supports the nation's expanding nuclear energy initiatives, placing INL at the center of work to develop advanced Generation IV nuclear energy systems; nuclear energy/hydrogen coproduction technology; advanced nuclear energy fuel cycle technologies; and providing national security answers to national infrastructure needs. As a result of the Laboratory's NE mission, INL generates both contact-handled and remote-handled transuranic (TRU) waste from ongoing operations. Generation rates are relatively small and fluctuate based on specific programs and project activities being conducted; however, the Laboratory will continue to generate TRU waste well into the future in association with the NE mission. Currently, plans and capabilities are being established to transfer INL's contact-handled TRU waste to the Advanced Mixed Waste Treatment Plant (AMWTP) for certification and disposal to the Waste Isolation Pilot Plant (WIPP). Remote-handled TRU waste is currently placed in storage at the Materials and Fuels Complex (MFC). In an effort to minimize future liabilities associated with the INL NE mission, INL is evaluating and assessing options for the management and disposition of all its TRU waste on a real-time basis at time of generation. This paper summarizes near-term activities to minimize future re handling of INL's TRU waste, as well as, potential complications associated with the long-term disposition of newly-generated TRU waste. Potential complications impacting the disposition of INL newly-generated TRU waste include, but are not limited to: (1

  4. Laboratory model study of newly deposited dredger fills using improved multiple-vacuum preloading technique

    Directory of Open Access Journals (Sweden)

    Jingjin Liu

    2017-10-01

    Full Text Available Problems continue to be encountered concerning the traditional vacuum preloading method in field during the treatment of newly deposited dredger fills. In this paper, an improved multiple-vacuum preloading method was developed to consolidate newly dredger fills that are hydraulically placed in seawater for land reclamation in Lingang Industrial Zone of Tianjin City, China. With this multiple-vacuum preloading method, the newly deposited dredger fills could be treated effectively by adopting a novel moisture separator and a rapid improvement technique without sand cushion. A series of model tests was conducted in the laboratory for comparing the results from the multiple-vacuum preloading method and the traditional one. Ten piezometers and settlement plates were installed to measure the variations in excess pore water pressures and moisture content, and vane shear strength was measured at different positions. The testing results indicate that water discharge–time curves obtained by the traditional vacuum preloading method can be divided into three phases: rapid growth phase, slow growth phase, and steady phase. According to the process of fluid flow concentrated along tiny ripples and building of larger channels inside soils during the whole vacuum loading process, the fluctuations of pore water pressure during each loading step are divided into three phases: steady phase, rapid dissipation phase, and slow dissipation phase. An optimal loading pattern which could have a best treatment effect was proposed for calculating the water discharge and pore water pressure of soil using the improved multiple-vacuum preloading method. For the newly deposited dredger fills at Lingang Industrial Zone of Tianjin City, the best loading step was 20 kPa and the loading of 40–50 kPa produced the highest drainage consolidation. The measured moisture content and vane shear strength were discussed in terms of the effect of reinforcement, both of which indicate

  5. [Formaldehyde-reducing efficiency of a newly developed dissection-table-connected local ventilation system in the gross anatomy laboratory room].

    Science.gov (United States)

    Shinoda, Koh; Oba, Jun

    2010-03-01

    In compliance with health and safety management guidelines against harmful formaldehyde (FA) levels in the gross anatomy laboratory, we newly developed a dissection-table-connected local ventilation system in 2006. The system was composed of (1) a simple plenum-chambered dissection table with low-cost filters, (2) a transparent vinyl flexible duct for easy mounting and removal, which connects the table and the exhaust pipe laid above the ceiling, and (3) an intake creating a downward-flow of air, which was installed on the ceiling just above each table. The dissection table was also designed as a separate-component system, of which the upper plate and marginal suction inlets can be taken apart for cleaning after dissection, and equipped with opening/closing side-windows for picking up materials dropped during dissection and a container underneath the table to receive exudate from the cadaver through a waste-fluid pipe. The local ventilation system dramatically reduced FA levels to 0.01-0.03 ppm in the gross anatomy laboratory room, resulting in no discomforting FA smell and irritating sensation while preserving the student's view of room and line of flow as well as solving the problems of high maintenance cost, sanitation issues inside the table, and working-inconvenience during dissection practice. Switching ventilation methods or power-modes, the current local ventilation system was demonstrated to be more than ten times efficient in FA reduction compared to the whole-room ventilation system and suggested that 11 m3/min/table in exhaust volume should decrease FA levels in both A- and B-measurements to less than 0.1 ppm in 1000 m3 space containing thirty-one 3.5%-FA-fixed cadavers.

  6. A newly development RIA for thyroid hormone autoantibodies (THAAb)

    International Nuclear Information System (INIS)

    Li Fengying; Gu Liqiong; Chen Xiayin; Jin Yan; Chen Shuxian; Zhang Qun; Qiu Hongxia; Yang Jingren; Zhao Yongju; Chen Mingdao

    2004-01-01

    Objective: To report a newly developed RIA for THAAb from this laboratory. Methods: The tested serum samples were cultured with labelled thyroid hormone analogous ( 125 I T 3 , 125 I T 4 ) for 16 hours. Antigen-antibody complex was precipitated with anti-human IgG (immune precipitation method) and radio-activity determined. Results: The mean positive rate of THAAb in healthy euthyroid controls (n=186) was only 1.07%. The mean positive rate in patients with thyroid disorders was 14.4% (mean rate 13.5% in hyperthyroid subjects, n=118 and mean rate 15.2% in hypothyroid subjects, n=72). The serum THAAb titer could be markedly lowered after adding non-labelled thyroid hormones (P 3 and FT 4 would be significantly lowered (P 3 , FT 4 levels. In patients with positive THAAb (about 14.4% in patients with all thyroid disorders), the FT 3 , FT 4 levels were best determined after PEG precipitation. (authors)

  7. Vehicle Development Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Supports the development of prototype deployment platform vehicles for offboard countermeasure systems.DESCRIPTION: The Vehicle Development Laboratory is...

  8. Sizing Performance of the Newly Developed Eddy Current System

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Chan Hee; Lee, Hee Jong; Yoo, Hyun Ju; Moon, Gyoon Young; Lee, Tae Hoon [Korea Hydro and Nuclear Power Co., Ltd., Daejeon (Korea, Republic of)

    2013-10-15

    This paper describes the comparison results of sizing performance for two systems. The KHNP developed a new eddy current testing system for the inspection of steam generator tubing in domestic nuclear power plants. The equivalency assessment of the newly developed system with the EPRI-qualified system was already carried out. In this paper, the comparisons of depth-sizing performance for the artificial flaws between two systems were performed. The results show that the newly developed system is in good agreement with the qualified system. Therefore, it is expected that the newly developed eddy current system can be used for the inspection of steam generator tubing in nuclear power plants. There are some non-destructive examination (NDE) methods for the inspection of components in nuclear power plants, such as ultrasonic, radiographic, eddy current testing, etc. The eddy current testing is widely used for the inspection of steam generator (SG) tubing because it offers a relatively low cost approach for high speed, large scale testing of metallic materials in high pressure and temperature engineering systems. The Korea Hydro and Nuclear Power Co., Ltd. (KHNP) developed an eddy current testing system for the inspection of steam generator tubing in nuclear power plants. This system includes not only hardware but software such as the frequency generator and data acquisition-analysis program. The foreign eddy current system developed by ZETEC is currently used for the inspection of steam generator tubing in domestic nuclear power plants. The equivalency assessment between two systems was already carried out in accordance with the EPRI steam generator examination guidelines.

  9. Certification document for newly generated contact-handled transuranic waste

    International Nuclear Information System (INIS)

    Box, W.D.; Setaro, J.

    1984-01-01

    The US Department of Energy has requested that all national laboratories handling defense waste develop and augment a program whereby all newly generated contact-handled transuranic (TRU) waste be contained, stored, and then shipped to the Waste Isolation Pilot Plant (WIPP) in accordance with the requirements set forth in WIPP-DOE-114. The program described in this report delineates how Oak Ridge National Laboratory intends to comply with these requirements and lists the procedures used by each generator to ensure that their TRU wastes are certifiable for shipment to WIPP

  10. Phenology of Lymantria monacha (Lepidoptera:Lymantriidae) laboratory reared on spruce foliage or a newly developed artificial diet

    Science.gov (United States)

    Melody A. Keena; Alice Vandel; Oldrich. Pultar

    2010-01-01

    Lymantria monacha (L.) (Lepidoptera: Lymantriidae) is a Eurasian pest of conifers that has potential for accidental introduction into North America. The phenology over the entire life cycle for L. monacha individuals from the Czech Republic was compared on Picea glauca (Moench) Voss (white spruce) and a newly...

  11. Mapping subsurface in proximity to newly-developed sinkhole along roadway.

    Science.gov (United States)

    2013-02-01

    MS&T acquired electrical resistivity tomography profiles in immediate proximity to a newly-developed sinkhole in Nixa Missouri : The sinkhole has closed a well-traveled municipal roadway and threatens proximal infrastructure. The intent of this inves...

  12. NUMERICAL MODELLING OF THE SOIL BEHAVIOUR BY USING NEWLY DEVELOPED ADVANCED MATERIAL MODEL

    Directory of Open Access Journals (Sweden)

    Jan Veselý

    2017-02-01

    Full Text Available This paper describes a theoretical background, implementation and validation of the newly developed Jardine plastic hardening-softening model (JPHS model, which can be used for numerical modelling of the soils behaviour. Although the JPHS model is based on the elasto-plastic theory, like the Mohr-Coulomb model that is widely used in geotechnics, it contains some improvements, which removes the main disadvantages of the MC model. The presented model is coupled with an isotopically hardening and softening law, non-linear elastic stress-strain law, non-associated elasto-plastic material description and a cap yield surface. The validation of the model is done by comparing the numerical results with real measured data from the laboratory tests and by testing of the model on the real project of the tunnel excavation. The 3D numerical analysis is performed and the comparison between the JPHS, Mohr-Coulomb, Modified Cam-Clay, Hardening small strain model and monitoring in-situ data is done.

  13. Development of laboratory and process sensors to monitor particle size distribution of industrial slurries

    Energy Technology Data Exchange (ETDEWEB)

    Pendse, H.P.

    1992-10-01

    In this paper we present a novel measurement technique for monitoring particle size distributions of industrial colloidal slurries based on ultrasonic spectroscopy and mathematical deconvolution. An on-line sensor prototype has been developed and tested extensively in laboratory and production settings using mineral pigment slurries. Evaluation to date shows that the sensor is capable of providing particle size distributions, without any assumptions regarding their functional form, over diameters ranging from 0.1 to 100 micrometers in slurries with particle concentrations of 10 to 50 volume percents. The newly developed on-line sensor allows one to obtain particle size distributions of commonly encountered inorganic pigment slurries under industrial processing conditions without dilution.

  14. High acceptability of a newly developed urological practical skills training program.

    NARCIS (Netherlands)

    Vries, A.H. de; Luijk, S.J. van; Scherpbier, A.J.J.A.; Hendrikx, A.J.M.; Koldewijn, E.L.; Wagner, C.; Schout, B.M.A.

    2015-01-01

    Background: Benefits of simulation training are widely recognized, but its structural implementation into urological curricula remains challenging. This study aims to gain insight into current and ideal urological practical skills training and presents the outline of a newly developed skills

  15. High acceptability of a newly developed urological practical skills training program

    NARCIS (Netherlands)

    de Vries, A.H.; van Luijk, S.J.; Scherpbier, A.J.J.A.; Hendrikx, A.J.M.; Koldewijn, E.L.; Wagner, C.; Schout, B.M.A.

    2015-01-01

    Background: Benefits of simulation training are widely recognized, but its structural implementation into urological curricula remains challenging. This study aims to gain insight into current and ideal urological practical skills training and presents the outline of a newly developed skills

  16. The Case for Laboratory Developed Procedures

    Directory of Open Access Journals (Sweden)

    Karen L. Kaul MD, PhD

    2017-07-01

    Full Text Available An explosion of knowledge and technology is revolutionizing medicine and patient care. Novel testing must be brought to the clinic with safety and accuracy, but also in a timely and cost-effective manner, so that patients can benefit and laboratories can offer testing consistent with current guidelines. Under the oversight provided by the Clinical Laboratory Improvement Amendments, laboratories have been able to develop and optimize laboratory procedures for use in-house. Quality improvement programs, interlaboratory comparisons, and the ability of laboratories to adjust assays as needed to improve results, utilize new sample types, or incorporate new mutations, information, or technologies are positive aspects of Clinical Laboratory Improvement Amendments oversight of laboratory-developed procedures. Laboratories have a long history of successful service to patients operating under Clinical Laboratory Improvement Amendments. A series of detailed clinical examples illustrating the quality and positive impact of laboratory-developed procedures on patient care is provided. These examples also demonstrate how Clinical Laboratory Improvement Amendments oversight ensures accurate, reliable, and reproducible testing in clinical laboratories.

  17. Results from the Savannah River Laboratory model validation workshop

    International Nuclear Information System (INIS)

    Pepper, D.W.

    1981-01-01

    To evaluate existing and newly developed air pollution models used in DOE-funded laboratories, the Savannah River Laboratory sponsored a model validation workshop. The workshop used Kr-85 measurements and meteorology data obtained at SRL during 1975 to 1977. Individual laboratories used models to calculate daily, weekly, monthly or annual test periods. Cumulative integrated air concentrations were reported at each grid point and at each of the eight sampler locations

  18. Timing of revenue streams from newly recruited faculty: implications for faculty retention.

    Science.gov (United States)

    Joiner, Keith A; Hiteman, Sarah; Wormsley, Steven; St Germain, Patricia

    2007-12-01

    To determine the timing and magnitude of revenues generated by newly recruited faculty, to facilitate configuration of recruitment packages appropriately matched to expected financial returns. The aggregate of all positive cash flows to central college of medicine administration -- from research, clinical care, tuition, philanthropy, and royalties and patents, from all faculty newly recruited to the University of Arizona College of Medicine between 1998 and 2004 -- was quantified using the net present value (npv) methodology, which incorporates the time value of money. Tenure-track faculty and, in particular, those with laboratory research programs, generated the highest positive central cash flows. The npv for positive cash flows (npv[+]) during 6 and 10 years for newly recruited assistant professors with laboratory research programs were $118,600 and $255,400, respectively, and, for professors with laboratory research programs, $172,600 and $298,000, respectively (associate professors were not analyzed because of limited numbers). Faculty whose appointments at the University of Arizona College of Medicine exceeded 15 years in duration were the most productive in central revenue generation, far in excess of their numbers proportionate to the total. The results emphasize the critical importance of faculty retention, because even those newly recruited faculty who are most successful in central revenue generation (tenure track with laboratory research programs) must be retained for periods well in excess of 10 years to recoup the initial central investment required for their recruitment.

  19. Development of volumetric methane measurement instrument for laboratory scale anaerobic reactors

    International Nuclear Information System (INIS)

    Sahito, A.R.

    2015-01-01

    In the present study, a newly developed VMMI (volumetric Methane-Measuring Instrument) for laboratory scale anaerobic reactors is presented. The VMMI is a reliable, inexpensive, easy to construct, easy to use, corrosion resistant device that does not need maintenance, can measure a wide flow range of gas at varying pressure and temperature. As per the results of the error analysis, the accuracy of the VMMI is unilateral, i.e. -6.91 %. The calibration of VMMI was investigated and a linear variation was found; hence, in situ calibration is recommended for this type of instrument. As per chromatographic analysis, it absorbs almost 100% of the carbon dioxide present in the biogas, results only the methane, and thus eliminates the need of cost intensive composition analysis of biogas through gas chromatograph. (author)

  20. Development of the Global Measles Laboratory Network.

    Science.gov (United States)

    Featherstone, David; Brown, David; Sanders, Ray

    2003-05-15

    The routine reporting of suspected measles cases and laboratory testing of samples from these cases is the backbone of measles surveillance. The Global Measles Laboratory Network (GMLN) has developed standards for laboratory confirmation of measles and provides training resources for staff of network laboratories, reference materials and expertise for the development and quality control of testing procedures, and accurate information for the Measles Mortality Reduction and Regional Elimination Initiative. The GMLN was developed along the lines of the successful Global Polio Laboratory Network, and much of the polio laboratory infrastructure was utilized for measles. The GMLN has developed as countries focus on measles control activities following successful eradication of polio. Currently more than 100 laboratories are part of the global network and follow standardized testing and reporting procedures. A comprehensive laboratory accreditation process will be introduced in 2002 with six quality assurance and performance indicators.

  1. Laboratory directed research and development

    Energy Technology Data Exchange (ETDEWEB)

    1991-11-15

    The purposes of Argonne's Laboratory Directed Research and Development (LDRD) Program are to encourage the development of novel concepts, enhance the Laboratory's R D capabilities, and further the development of its strategic initiatives. Among the aims of the projects supported by the Program are establishment of engineering proof-of-principle''; development of an instrumental prototype, method, or system; or discovery in fundamental science. Several of these project are closely associated with major strategic thrusts of the Laboratory as described in Argonne's Five Year Institutional Plan, although the scientific implications of the achieved results extend well beyond Laboratory plans and objectives. The projects supported by the Program are distributed across the major programmatic areas at Argonne. Areas of emphasis are (1) advanced accelerator and detector technology, (2) x-ray techniques in biological and physical sciences, (3) advanced reactor technology, (4) materials science, computational science, biological sciences and environmental sciences. Individual reports summarizing the purpose, approach, and results of projects are presented.

  2. Planning for the Management and Disposition of Newly Generated TRU Waste from REDC

    International Nuclear Information System (INIS)

    Coffey, D. E.; Forrester, T. W.; Krause, T.

    2002-01-01

    This paper describes the waste characteristics of newly generated transuranic waste from the Radiochemical Engineering and Development Center at the Oak Ridge National Laboratory and the basic certification structure that will be proposed by the University of Tennessee-Battelle and Bechtel Jacobs Company LLC to the Waste Isolation Pilot Plant for this waste stream. The characterization approach uses information derived from the active production operations as acceptable knowledge for the Radiochemical Engineering and Development Center transuranic waste. The characterization approach includes smear data taken from processing and waste staging hot cells, as well as analytical data on product and liquid waste streams going to liquid waste disposal. Bechtel Jacobs Company and University of Tennessee-Battelle are currently developing the elements of a Waste Isolation Pilot Plant-compliant program with a plan to be certified by the Waste Isolation Pilot Plant for shipment of newly generated transuranic waste in the next few years. The current activities include developing interface plans, program documents, and waste stream specific procedures

  3. An Evaluation of a Human Development Laboratory. A Study of the Outcome and Process of a Laboratory Learning Experience

    Science.gov (United States)

    1977-08-01

    Lewis, W. A. Sensitivity training mutual emotional masturbation ? Personnel and Guidance Journal, 1970, 48, 525. L’Herisson, L., and Krumm, K. J. Changes...for the purpose of practicing their newly learned skills. The groups were formed by the participants’ selecting members of the laboratory with whom...34how" it is said) are con- ji 83 gruent. After this input, the participants returned to their respective small groups to continue practicing the skills

  4. Quantification of Fusarium oxysporum in fumigated soils by a newly developed real-time PCR assay to assess the efficacy of fumigants for Fusarium wilt disease in strawberry plants.

    Science.gov (United States)

    Li, Yuan; Mao, Liangang; Yan, Dongdong; Ma, Taotao; Shen, Jin; Guo, Meixia; Wang, Qiuxia; Ouyang, Canbin; Cao, Aocheng

    2014-11-01

    Two soil fumigants, chloropicrin (CP) and dimethyl disulfide (DMDS), were used to control Fusarium wilt disease (FWD) which caused large economic losses in strawberries. The fumigants were evaluated alone and in combination in a laboratory study and in strawberry greenhouses. Laboratory tests found that combinations of CP and DMDS indicated a positive synergistic activity on Fusarium oxysporum. A newly developed quantitative assay for F. oxysporum involving real-time PCR was used successfully to evaluate F. oxysporum control by the fumigants; it provided similar results to the selective medium but was less time-consuming and less labor intensive. Greenhouse trials revealed that the combination of CP and DMDS successfully suppressed the incidence of FWD and sharply reduced the population density of F. oxysporum, which significantly increased fruit branch number and maintained a good strawberry yield, higher than methyl bromide (MB) treatment. All of the treatments provided significantly better results than the non-treated control. This study confirms that the newly developed real-time PCR quantitative assay for F. oxysporum was suitable for the control efficacy evaluation of soil fumigants and that the novel fumigant combination of CP and DMDS offers a promising effective alternative to MB for the control of F. oxysporum in strawberry greenhouses. © 2013 Society of Chemical Industry.

  5. A review of international underground laboratory developments

    International Nuclear Information System (INIS)

    Cheng Jianping; Yue Qian; Wu Shiyong; Shen Manbin

    2011-01-01

    Underground laboratories are essential for various important physics areas such as the search for dark matter, double beta decay, neutrino oscillation, and proton decay. At the same time, they are also a very important location for studying rock mechanics, earth structure evolution,and ecology. It is essential for a nation's basic research capability to construct and develop underground laboratories. In the past, China had no high-quality underground laboratory,in particular no deep underground laboratory,so her scientists could not work independently in major fields such as the search for dark matter,but had to collaborate with foreign scientists and share the space of foreign underground laboratories. In 2009, Tsinghua university collaborated with the Ertan Hydropower Development Company to construct an extremely deep underground laboratory, the first in China and currently the deepest in the world, in the Jinping traffic tunnel which was built to develop hydropower from the Yalong River in Sichuan province. This laboratory is named the China Jinping Underground Laboratory (CJPL) and formally opened on December 12, 2010. It is now a major independent platform in China and can host various leading basic research projects. We present a brief review of the development of various international underground laboratories,and especially describe CJPL in detail. (authors)

  6. Laboratory accreditation in developing economies

    International Nuclear Information System (INIS)

    Loesener, O.

    2004-01-01

    Full text: Accreditation of laboratories has been practiced for well over one hundred years with the primary objective of seeking a formal recognition for the competence of a laboratory to perform specified tests or measurements. While first accreditation schemes intended initially to serve only the immediate needs of the body making the evaluation with the purpose of minimizing testing and inspection to be conducted by laboratories, third-party accreditation enables a laboratory to demonstrate its capability as well as availability of all necessary resources to undertake particular tests correctly and that is managed in such a way that it is likely to do this consistently, taking into consideration standards developed by national and international standards-setting bodies. The international standard ISO/IEC 17025 and laboratory accreditation are concerned with competence and quality management of laboratories only, thus requiring a single common set of criteria applicable to them. Quality assurance is therefore fully relevant to laboratories in general and analytical laboratories in particular; it should not be confused with the certification approach according to ISO/IEC 9000 family of standards, that is concerned with quality management applicable to any organization as a whole. The role of laboratory accreditation can be manifold, but in all cases the recipient of the test report needs to have confidence that the data in it is reliable, particularly if the test data is important in a decision-making process. As such, it offers a comprehensive way to ensure: - the availability of managerial and technical staff with the authority and resources needed; - the effectiveness of equipment management, traceability of measurement and safety procedures; - the performance of tests, taking into consideration laboratory accommodation and facilities as well as laboratory practices. The presentation will include also some practical aspects of quality management system

  7. A professional development model for medical laboratory scientists working in the microbiology laboratory.

    Science.gov (United States)

    Amerson, Megan H; Pulido, Lila; Garza, Melinda N; Ali, Faheem A; Greenhill, Brandy; Einspahr, Christopher L; Yarsa, Joseph; Sood, Pramilla K; Hu, Peter C

    2012-01-01

    The University of Texas M.D. Anderson Cancer Center, Division of Pathology and Laboratory Medicine is committed to providing the best pathology and medicine through: state-of-the art techniques, progressive ground-breaking research, education and training for the clinical diagnosis and research of cancer and related diseases. After surveying the laboratory staff and other hospital professionals, the Department administrators and Human Resource generalists developed a professional development model for Microbiology to support laboratory skills, behavior, certification, and continual education within its staff. This model sets high standards for the laboratory professionals to allow the labs to work at their fullest potential; it provides organization to training technologists based on complete laboratory needs instead of training technologists in individual areas in which more training is required if the laboratory needs them to work in other areas. This model is a working example for all microbiology based laboratories who want to set high standards and want their staff to be acknowledged for demonstrated excellence and professional development in the laboratory. The PDM model is designed to focus on the needs of the laboratory as well as the laboratory professionals.

  8. Improving a newly developed patient-reported outcome for thyroid patients, using cognitive interviewing

    DEFF Research Database (Denmark)

    Watt, Torquil; Rasmussen, Ase Krogh; Groenvold, Mogens

    2008-01-01

    Objective To improve a newly developed patient-reported outcome measure for thyroid patients using cognitive interviewing. Methods Thirty-one interviews using immediate retrospective and expansive probing were conducted among patients with non-toxic goiter (n = 4), nodular toxic goiter (n = 5) Gr...

  9. Newly Developed Ceramic Membranes for Dehydration and Separation of Organic Mixtures by Pervaporation

    NARCIS (Netherlands)

    Gemert, van R.W.; Cuperus, F.P.

    1995-01-01

    Polymeric pervaporation membranes sometimes show great variety in performance when they are alternately used for different solvent mixtures. In addition, membrane stability in time is a problem in case of some solvents. Therefore, newly developed ceramic silica membranes with a 'dense' top layer

  10. Aviation Information Systems Development Laboratory (AISDL)

    Data.gov (United States)

    Federal Laboratory Consortium — Purpose:The Aviation Information Systems Development Laboratory (AISDL) provides the tools, reconfigurability and support to ensure the quality and integrity of new...

  11. Initial laboratory evaluation of color video cameras: Phase 2

    Energy Technology Data Exchange (ETDEWEB)

    Terry, P.L.

    1993-07-01

    Sandia National Laboratories has considerable experience with monochrome video cameras used in alarm assessment video systems. Most of these systems, used for perimeter protection, were designed to classify rather than to identify intruders. The monochrome cameras were selected over color cameras because they have greater sensitivity and resolution. There is a growing interest in the identification function of security video systems for both access control and insider protection. Because color camera technology is rapidly changing and because color information is useful for identification purposes, Sandia National Laboratories has established an on-going program to evaluate the newest color solid-state cameras. Phase One of the Sandia program resulted in the SAND91-2579/1 report titled: Initial Laboratory Evaluation of Color Video Cameras. The report briefly discusses imager chips, color cameras, and monitors, describes the camera selection, details traditional test parameters and procedures, and gives the results reached by evaluating 12 cameras. Here, in Phase Two of the report, we tested 6 additional cameras using traditional methods. In addition, all 18 cameras were tested by newly developed methods. This Phase 2 report details those newly developed test parameters and procedures, and evaluates the results.

  12. National Laboratory Planning: Developing Sustainable Biocontainment Laboratories in Limited Resource Areas.

    Science.gov (United States)

    Yeh, Kenneth B; Adams, Martin; Stamper, Paul D; Dasgupta, Debanjana; Hewson, Roger; Buck, Charles D; Richards, Allen L; Hay, John

    2016-01-01

    Strategic laboratory planning in limited resource areas is essential for addressing global health security issues. Establishing a national reference laboratory, especially one with BSL-3 or -4 biocontainment facilities, requires a heavy investment of resources, a multisectoral approach, and commitments from multiple stakeholders. We make the case for donor organizations and recipient partners to develop a comprehensive laboratory operations roadmap that addresses factors such as mission and roles, engaging national and political support, securing financial support, defining stakeholder involvement, fostering partnerships, and building trust. Successful development occurred with projects in African countries and in Azerbaijan, where strong leadership and a clear management framework have been key to success. A clearly identified and agreed management framework facilitate identifying the responsibility for developing laboratory capabilities and support services, including biosafety and biosecurity, quality assurance, equipment maintenance, supply chain establishment, staff certification and training, retention of human resources, and sustainable operating revenue. These capabilities and support services pose rate-limiting yet necessary challenges. Laboratory capabilities depend on mission and role, as determined by all stakeholders, and demonstrate the need for relevant metrics to monitor the success of the laboratory, including support for internal and external audits. Our analysis concludes that alternative frameworks for success exist for developing and implementing capabilities at regional and national levels in limited resource areas. Thus, achieving a balance for standardizing practices between local procedures and accepted international standards is a prerequisite for integrating new facilities into a country's existing public health infrastructure and into the overall international scientific community.

  13. Raising Environmental Awareness through Applied Biochemistry Laboratory Experiments

    Science.gov (United States)

    Salman Ashraf, S.

    2013-01-01

    Our environment is under constant pressure and threat from various sources of pollution. Science students, in particular chemistry students, must not only be made aware of these issues, but also be taught that chemistry (and science) can provide solutions to such real-life issues. To this end, a newly developed biochemistry laboratory experiment…

  14. Light Guide Collector Prototype: Laboratory Testing

    OpenAIRE

    Jitka - Mohelnikova; Stanislav Darula; Ayodeji Omishore; Petr Mohelnik; Denis Micek

    2017-01-01

    The article reviews the potential of light guide system equipped by a concentrator device capturing daylight applicable for illumination of building interiors and presents results of experiments on performance of its prototype. The main goal is focused on the comparison of traditional solutions and newly developed prototype of the light guide system and presents examination of its light transmission efficiency based on the laboratory experiments.

  15. Laboratory Directed Research ampersand Development Program

    International Nuclear Information System (INIS)

    Ogeka, G.J.; Romano, A.J.

    1993-12-01

    At Brookhaven National Laboratory the Laboratory Directed Research and Development (LDRD) Program is a discretionary research and development tool critical in maintaining the scientific excellence and vitality of the laboratory. It is also a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor in achieving and maintaining staff excellence, and a means to address national needs, within the overall mission of the Department of Energy and Brookhaven National Laboratory. This report summarizes research which was funded by this program during fiscal year 1993. The research fell in a number of broad technical and scientific categories: new directions for energy technologies; global change; radiation therapies and imaging; genetic studies; new directions for the development and utilization of BNL facilities; miscellaneous projects. Two million dollars in funding supported 28 projects which were spread throughout all BNL scientific departments

  16. Los Alamos Plutonium Facility newly generated TRU waste certification

    International Nuclear Information System (INIS)

    Gruetzmacher, K.; Montoya, A.; Sinkule, B.; Maez, M.

    1997-01-01

    This paper presents an overview of the activities being planned and implemented to certify newly generated contact handled transuranic (TRU) waste produced by Los Alamos National Laboratory's (LANL's) Plutonium Facility. Certifying waste at the point of generation is the most important cost and labor saving step in the WIPP certification process. The pedigree of a waste item is best known by the originator of the waste and frees a site from expensive characterization activities such as those associated with legacy waste. Through a cooperative agreement with LANLs Waste Management Facility and under the umbrella of LANLs WIPP-related certification and quality assurance documents, the Plutonium Facility will be certifying its own newly generated waste. Some of the challenges faced by the Plutonium Facility in preparing to certify TRU waste include the modification and addition of procedures to meet WIPP requirements, standardizing packaging for TRU waste, collecting processing documentation from operations which produce TRU waste, and developing ways to modify waste streams which are not certifiable in their present form

  17. The Development Needs of Newly Appointed Senior School Leaders in the Western Cape South Africa: A Case Study

    Directory of Open Access Journals (Sweden)

    Nelius Jansen van Vuuren

    2017-12-01

    Full Text Available The essential role that senior school leaders play in school leadership teams to ensure effective strategic leadership in schools has been the subject of intense discussion for many years. Crucial to this debate is the establishment of professional learning and leadership approaches for newly appointed senior school leaders. Recommendations for policy and practice highlight the importance of appropriate, multifaceted, developmental support initiatives for newly appointed school leaders. In many countries, including South Africa, a teaching qualification and, in most cases, extensive teaching experience is the only requirement for being appointed as a senior school leader in a school. This tends to suggest that no further professional development is required for newly appointed school leaders, the problem addressed in this paper. This paper reports on the main findings of the perceived development needs of newly appointed senior school leaders in the Western Cape, South Africa, and suggests that school leaders occupy a unique and specialist role in education, which requires relevant and specific preparation to support effective leadership. The respondents of this study report a lack of contextualised training and support before and after their appointment in their new roles creating unique development needs. This paper, therefore, employs a mixed-method approach to gather data to understand the perceived needs of twenty newly appointed senior school leaders in the Western Cape, South Africa.

  18. Laboratory development and testing of spacecraft diagnostics

    Science.gov (United States)

    Amatucci, William; Tejero, Erik; Blackwell, Dave; Walker, Dave; Gatling, George; Enloe, Lon; Gillman, Eric

    2017-10-01

    The Naval Research Laboratory's Space Chamber experiment is a large-scale laboratory device dedicated to the creation of large-volume plasmas with parameters scaled to realistic space plasmas. Such devices make valuable contributions to the investigation of space plasma phenomena under controlled, reproducible conditions, allowing for the validation of theoretical models being applied to space data. However, in addition to investigations such as plasma wave and instability studies, such devices can also make valuable contributions to the development and testing of space plasma diagnostics. One example is the plasma impedance probe developed at NRL. Originally developed as a laboratory diagnostic, the sensor has now been flown on a sounding rocket, is included on a CubeSat experiment, and will be included on the DoD Space Test Program's STP-H6 experiment on the International Space Station. In this talk, we will describe how the laboratory simulation of space plasmas made this development path possible. Work sponsored by the US Naval Research Laboratory Base Program.

  19. Argonne National Laboratory: Laboratory Directed Research and Development FY 1993 program activities. Annual report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1993-12-23

    The purposes of Argonne`s Laboratory Directed Research and Development (LDRD) Program are to encourage the development of novel concepts, enhance the Laboratory`s R&D capabilities, and further the development of its strategic initiatives. Projects are selected from proposals for creative and innovative R&D studies which are not yet eligible for timely support through normal programmatic channels. Among the aims of the projects supported by the Program are establishment of engineering ``proof-of-principle`` assessment of design feasibility for prospective facilities; development of an instrumental prototype, method, or system; or discovery in fundamental science. Several of these projects are closely associated with major strategic thrusts of the Laboratory as described in Argonne`s Five Year Institutional Plan, although the scientific implications of the achieved results extend well beyond Laboratory plans and objectives. The projects supported by the Program are distributed across the major programmatic areas at Argonne as indicated in the Laboratory LDRD Plan for FY 1993.

  20. National Laboratory Planning: Developing Sustainable Biocontainment Laboratories in Limited Resource Areas

    OpenAIRE

    Yeh, Kenneth B.; Adams, Martin; Stamper, Paul D.; Dasgupta, Debanjana; Hewson, Roger; Buck, Charles D.; Richards, Allen L.; Hay, John

    2016-01-01

    Strategic laboratory planning in limited resource areas is essential for addressing global health security issues. Establishing a national reference laboratory, especially one with BSL-3 or -4 biocontainment facilities, requires a heavy investment of resources, a multisectoral approach, and commitments from multiple stakeholders. We make the case for donor organizations and recipient partners to develop a comprehensive laboratory operations roadmap that addresses factors such as mission and r...

  1. Light Guide Collector Prototype: Laboratory Testing

    Directory of Open Access Journals (Sweden)

    Jitka - Mohelnikova

    2017-12-01

    Full Text Available The article reviews the potential of light guide system equipped by a concentrator device capturing daylight applicable for illumination of building interiors and presents results of experiments on performance of its prototype. The main goal is focused on the comparison of traditional solutions and newly developed prototype of the light guide system and presents examination of its light transmission efficiency based on the laboratory experiments.

  2. Newly Generated Liquid Waste Processing Alternatives Study, Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Landman, William Henry; Bates, Steven Odum; Bonnema, Bruce Edward; Palmer, Stanley Leland; Podgorney, Anna Kristine; Walsh, Stephanie

    2002-09-01

    This report identifies and evaluates three options for treating newly generated liquid waste at the Idaho Nuclear Technology and Engineering Center of the Idaho National Engineering and Environmental Laboratory. The three options are: (a) treat the waste using processing facilities designed for treating sodium-bearing waste, (b) treat the waste using subcontractor-supplied mobile systems, or (c) treat the waste using a special facility designed and constructed for that purpose. In studying these options, engineers concluded that the best approach is to store the newly generated liquid waste until a sodium-bearing waste treatment facility is available and then to co-process the stored inventory of the newly generated waste with the sodium-bearing waste. After the sodium-bearing waste facility completes its mission, two paths are available. The newly generated liquid waste could be treated using the subcontractor-supplied system or the sodium-bearing waste facility or a portion of it. The final decision depends on the design of the sodium-bearing waste treatment facility, which will be completed in coming years.

  3. Laboratory Directed Research and Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Ogeka, G.J.

    1991-12-01

    Today, new ideas and opportunities, fostering the advancement of technology, are occurring at an ever-increasing rate. It, therefore, seems appropriate that a vehicle be available which fosters the development of these new ideas and technologies, promotes the early exploration and exploitation of creative and innovative concepts, and which develops new fundable'' R D projects and programs. At Brookhaven National Laboratory (BNL), one such method is through its Laboratory Directed Research and Development (LDRD) Program. This discretionary research and development tool is critical in maintaining the scientific excellence and vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor achieving and maintaining staff excellence, and a means to address national needs, with the overall mission of the Department of Energy (DOE) and the Brookhaven National Laboratory. The Project Summaries with their accomplishments described in this report reflect the above. Aside from leading to new fundable or promising programs and producing especially noteworthy research, they have resulted in numerous publications in various professional and scientific journals, and presentations at meetings and forums.

  4. Validating self-reported mobile phone use in adults using a newly developed smartphone application

    NARCIS (Netherlands)

    Goedhart, Geertje; Kromhout, Hans; Wiart, Joe; Vermeulen, Roel

    2015-01-01

    OBJECTIVE: Interpretation of epidemiological studies on health effects from mobile phone use is hindered by uncertainties in the exposure assessment. We used a newly developed smartphone application (app) to validate self-reported mobile phone use and behaviour among adults. METHODS: 107

  5. Developing linear-alpha-olefins technology. From laboratory to a commercial plant

    Energy Technology Data Exchange (ETDEWEB)

    Meiswinkel, A.; Woehl, A.; Mueller, W.; Boelt, H. [Linde AG, Pullach (Germany)

    2011-07-01

    Linear {alpha}-Olefins (LAOs) are used in several applications in chemical industry. Together with SABIC (Saudi Basic Industries Corporation) Linde jointly developed the {alpha}-SABLIN technology for a full range LAO plant as well as a 1-Hexene selective ''On Purpose'' technology (LAO OP) to cover the rapidly increasing demand for this specific comonomer. The {alpha}-SABLIN as well as the OP technology are both homogenously catalyzed systems. This is raising special challenges concerning process and reactor design compared to much more established heterogeneous systems in chemical industry. E.g., the reactor concept is a bubble-column which allows efficient mixing as well as cooling of the reaction mixture. The development of the process was based on laboratory experiments which - based on an initial conceptual design for a large scale technical process - were first transformed into a pilot device before the commercial plant was designed, engineered and successfully started up and declared as commercialized. Today the {alpha}-SABLIN technology is the only LAO technology with a commercial reference which is free for licensing. A lot of experience and knowledge from the {alpha}-SABLIN development and commercial operation was gained. Although newly developed OP technology is based on a different catalytic system, this experience is now utilized and transformed within the commercialization of this new technological development. (orig.)

  6. Micro-computed tomography newly developed for in vivo small animal imaging

    International Nuclear Information System (INIS)

    Arai, Yoshinori; Ninomiya, Tadashi; Kato, Takafumi; Masuda, Yuji

    2005-01-01

    The aim of this paper is to report a newly developed micro-computed tomography system for in vivo use. The system was composed of a micro-focus X-ray tube and an image intensifier (I.I.), both of which rotated around the object stage. A guinea pig and a rat were examined. The anesthetized animal was set on the secure object stage. Images of the head of the guinea pig and the tibia knee joint of the rat were taken. In addition, an image of the rat's tail was taken. The reconstruction and the image viewing were carried out using I-View software. The voxel matrix was 512 x 512 x 384. The voxel sizes ranged from 10 x 10 x 10 μm to 100 x 100 x 100 μm. The exposure time was 17 s, and the reconstruction time was 150 s. The head of the guinea pig and the tibia/knee joint of the rat were observed clearly under 100-μm and 30μm voxels, respectively. The trabecular bone of the tail was also observed clearly under a 10 μm voxel. The newly developed micro-computed tomography system makes it possible to obtain images of anesthetized animals set on a secure object stage. Clear bone images of the small animals could be obtained within a short time. (author)

  7. Development and integration of modern laboratories in aerospace education

    Science.gov (United States)

    Desautel, D.; Hunter, N.; Mourtos, N.; Pernicka, H.

    1992-01-01

    This paper describes the development and integration of a suite of laboratories in an aerospace engineering program. The program's approach to undergraduate education is described as the source for the development of the supporting laboratories. Nine laboratories supporting instruction were developed and installed. The nine laboratories include most major flight-vehicle disciplines. The purpose and major equipments/experiments of each laboratory are briefly described, as is the integration of the laboratory with coursework. The laboratory education provided by this program successfully achieves its purpose of producing competitive aerospace engineering graduates and advancing the level of undergraduate education.

  8. Fuel Cell Development and Test Laboratory | Energy Systems Integration

    Science.gov (United States)

    Facility | NREL Fuel Cell Development and Test Laboratory Fuel Cell Development and Test Laboratory The Energy System Integration Facility's Fuel Cell Development and Test Laboratory supports fuel cell research and development projects through in-situ fuel cell testing. Photo of a researcher running

  9. Assessing College Students' Perceptions of a Case Teacher's Pedagogical Content Knowledge Using a Newly Developed Instrument

    Science.gov (United States)

    Jang, Syh-Jong

    2011-01-01

    Ongoing professional development for college teachers has been much emphasized. However, previous research on learning environments has seldom addressed college students' perceptions of teachers' PCK. This study aimed to evaluate college students' perceptions of a physics teacher's PCK development using a newly developed instrument and workshop…

  10. Laboratory directed research and development program, FY 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-02-01

    The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab) Laboratory Directed Research and Development Program FY 1996 report is compiled from annual reports submitted by principal investigators following the close of the fiscal year. This report describes the projects supported and summarizes their accomplishments. It constitutes a part of the Laboratory Directed Research and Development (LDRD) program planning and documentation process that includes an annual planning cycle, projection selection, implementation, and review. The Berkeley Lab LDRD program is a critical tool for directing the Laboratory`s forefront scientific research capabilities toward vital, excellent, and emerging scientific challenges. The program provides the resources for Berkeley Lab scientists to make rapid and significant contributions to critical national science and technology problems. The LDRD program also advances the Laboratory`s core competencies, foundations, and scientific capability, and permits exploration of exciting new opportunities. Areas eligible for support include: (1) Work in forefront areas of science and technology that enrich Laboratory research and development capability; (2) Advanced study of new hypotheses, new experiments, and innovative approaches to develop new concepts or knowledge; (3) Experiments directed toward proof of principle for initial hypothesis testing or verification; and (4) Conception and preliminary technical analysis to explore possible instrumentation, experimental facilities, or new devices.

  11. Applicability of newly developed 610MPa class heavy thickness high strength steel to boiler pressure vessel

    Energy Technology Data Exchange (ETDEWEB)

    Katayama, Norihiko; Kaihara, Shoichiro; Ishii, Jun [Ishikawajima-Harima Heavy Industries Corp., Yokohama (Japan); Kajigaya, Ichiro [Ishikawajima-Harima Heavy Industries Corp., Tokyo (Japan); Totsuka, Takehiro; Miyazaki, Takashi [Ishikawajima-Harima Heavy Industries Corp., Aioi (Japan)

    1995-11-01

    Construction of a 350 MW Class PFBC (Pressurized Fluidized Bed Combustion) boiler plant is under planning in Japan. Design temperature and pressure of the vessel are maximum 350 C and 1.69 MPa, respectively. As the plate thickness of the vessel exceeds over 100 mm, high strength steel plate of good weldability and less susceptible to reheat cracking was required and developed. The steel was aimed to satisfy the tensile strength over 610 MPa at 350 C after postweld heat treatment (PWHT), with good notch toughness. The authors investigated the welding performances of the newly developed steel by using 150 mm-thick plate welded by pulsed-MAG and SAW methods. It was confirmed that the newly developed steel and its welds possess sufficient strength and toughness after PWHT, and applicable to the actual pressure vessel.

  12. Fundamental Characteristics of the Newly Developed ATA™ Membrane Dialyzer.

    Science.gov (United States)

    Sunohara, Takashi; Masuda, Toshiaki

    2017-01-01

    Dialysis membranes are often made from synthetic polymers, such as polysulfone. However, membranes made from cellulose triacetate have superior biocompatibility and have been used since the 1980s. On-line hemodiafiltration treatment accompanied by massive fluid replacement is increasingly being used in Europe and Japan, but cellulose triacetate is not suitable for this treatment. Our newly developed asymmetric triacetate membrane, the ATA™ membrane, substantially improved the filtration properties and blood compatibility because of the asymmetric structure and smooth surface of this cellulose acetate membrane. Key Message: The ATA membrane maintains its high permeability even after massive filtration and shows less temporal variation in its permeation performance, lower protein adsorption, and superior biocompatibility compared with conventional membranes. © 2017 S. Karger AG, Basel.

  13. Egg and early larval development of laboratory reared dusky grouper, Epinephelus marginatus (Lowe, 1834 (Picies, Serranidae

    Directory of Open Access Journals (Sweden)

    Branko Glamuzina

    1998-12-01

    Full Text Available The embryonic and early larval development of the laboratory-reared dusky grouper, Epinephelus marginatus (Lowe, 1834 are described and illustrated. The eggs, with a mean diameter of 846.68 ± 41 µm and a range from 736-940 µm, were spherical and transparent with transparent chorion. Embryonic development lasted 30 hours at 23°C. Newly-hatched larvae were 1.52 ± 0.066 mm in length. Absorption of the yolk sac was complete after the fourth day, when larvae reached 2.63 ± 0.123 mm in total length. The mouth opened 72 hours after hatching, and was in function after 96 hours, with an opening diameter ranging from 250-300 µm. Larvae had two fields of intensive pigmentation, one above the intestine, and the other between the anus and the end of the notochord.

  14. PHL10/460: Cancerfacts.com - Vertical Portal with Newly Developed Health Profiler

    OpenAIRE

    Lenz, C; Brucksch, M

    1999-01-01

    Introduction Unlike general health portals such as WebMD and Drkoop.com that cover everything from the flu to heart disease, Silicon Valley-based cancerfacts.com is a so-called vertical portal. It covers only one small vertical niche of health care: cancer, and in particular, prostate cancer. As a value-added proprietary technology, the company offers its newly developed profile engine to health information retrievers. Methods Users are enabled to insert their specific medical information - r...

  15. Photovoltaic module certification/laboratory accreditation criteria development

    Energy Technology Data Exchange (ETDEWEB)

    Osterwald, C.R. [National Renewable Energy Lab., Golden, CO (United States); Hammond, R.L.; Wood, B.D.; Backus, C.E.; Sears, R.L. [Arizona State Univ., Tempe, AZ (United States); Zerlaut, G.A. [SC-International Inc., Phoenix, AZ (United States); D`Aiello, R.V. [RD Associates, Tempe, AZ (United States)

    1995-04-01

    This document provides an overview of the structure and function of typical product certification/laboratory accreditation programs. The overview is followed by a model program which could serve as the basis for a photovoltaic (PV) module certification/laboratory accreditation program. The model covers quality assurance procedures for the testing laboratory and manufacturer, third-party certification and labeling, and testing requirements (performance and reliability). A 30-member Criteria Development Committee was established to guide, review, and reach a majority consensus regarding criteria for a PV certification/laboratory accreditation program. Committee members represented PV manufacturers, end users, standards and codes organizations, and testing laboratories.

  16. 1999 LDRD Laboratory Directed Research and Development

    Energy Technology Data Exchange (ETDEWEB)

    Rita Spencer; Kyle Wheeler

    2000-06-01

    This is the FY 1999 Progress Report for the Laboratory Directed Research and Development (LDRD) Program at Los Alamos National Laboratory. It gives an overview of the LDRD Program, summarizes work done on individual research projects, relates the projects to major Laboratory program sponsors, and provides an index to the principal investigators. Project summaries are grouped by their LDRD component: Competency Development, Program Development, and Individual Projects. Within each component, they are further grouped into nine technical categories: (1) materials science, (2) chemistry, (3) mathematics and computational science, (4) atomic, molecular, optical, and plasma physics, fluids, and particle beams, (5) engineering science, (6) instrumentation and diagnostics, (7) geoscience, space science, and astrophysics, (8) nuclear and particle physics, and (9) bioscience.

  17. Idaho Nuclear Technology and Engineering Center Newly Generated Liquid Waste Demonstration Project Feasibility Study

    International Nuclear Information System (INIS)

    Herbst, A.K.

    2000-01-01

    A research, development, and demonstration project for the grouting of newly generated liquid waste (NGLW) at the Idaho Nuclear Technology and Engineering Center is considered feasible. NGLW is expected from process equipment waste, decontamination waste, analytical laboratory waste, fuel storage basin waste water, and high-level liquid waste evaporator condensate. The potential grouted waste would be classed as mixed low-level waste, stabilized and immobilized to meet RCRA LDR disposal in a grouting process in the CPP-604 facility, and then transported to the state

  18. Laboratory directed research and development program, FY 1996

    International Nuclear Information System (INIS)

    1997-02-01

    The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab) Laboratory Directed Research and Development Program FY 1996 report is compiled from annual reports submitted by principal investigators following the close of the fiscal year. This report describes the projects supported and summarizes their accomplishments. It constitutes a part of the Laboratory Directed Research and Development (LDRD) program planning and documentation process that includes an annual planning cycle, projection selection, implementation, and review. The Berkeley Lab LDRD program is a critical tool for directing the Laboratory's forefront scientific research capabilities toward vital, excellent, and emerging scientific challenges. The program provides the resources for Berkeley Lab scientists to make rapid and significant contributions to critical national science and technology problems. The LDRD program also advances the Laboratory's core competencies, foundations, and scientific capability, and permits exploration of exciting new opportunities. Areas eligible for support include: (1) Work in forefront areas of science and technology that enrich Laboratory research and development capability; (2) Advanced study of new hypotheses, new experiments, and innovative approaches to develop new concepts or knowledge; (3) Experiments directed toward proof of principle for initial hypothesis testing or verification; and (4) Conception and preliminary technical analysis to explore possible instrumentation, experimental facilities, or new devices

  19. Secondary standard dosimetry laboratories: Development and trends

    International Nuclear Information System (INIS)

    1985-08-01

    This publication describes the work of the IAEA and the WHO in the establishment of a network of Secondary Standard Dosimetry Laboratories. Membership in the SSDL network has now risen to about 50 laboratories, of which 36 are in developing countries

  20. Newly developed semi-empirical formulas for (p, α) at 17.9 MeV and ...

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics; Volume 74; Issue 6. Newly developed semi-empirical formulas for (, ) at 17.9 MeV and (, ) at 22.3 MeV reaction cross-sections. Eyyup Tel Abdullah Aydin E Gamze Aydin Abdullah Kaplan Ömer Yavaş İskender A Reyhancan. Research Articles Volume 74 Issue 6 June ...

  1. The newly developed Toyota plug-in hybrid system

    Energy Technology Data Exchange (ETDEWEB)

    Takaoka, Toshifumi; Ichinose, Hiroki [Toyota Motor Corporation (Japan)

    2010-07-01

    Toyota has been introducing several hybrid vehicles (HV) as a countermeasure to the automobile's concerns, like CO2 reduction, energy security, and emission reduction in urban areas. A next step towards an even more effective solution for these concerns is a plug-in hybrid vehicle (PHV). This vehicle combines the advantages of electric vehicles (EV), which use clean electric energy, and HV, with it's high environmental potential and user- friendliness comparable to conventional vehicles, such as a long cruising range. This paper describes a newly developed plug-in hybrid system and its vehicle performance. This system uses a Li-ion battery with high energy density and has an affordable EV range without sacrificing cabin space. The vehicle achieves a CO2 emission of 59g/km and meets the most stringent emission regulations in the world. The new PHV is a forerunner of the large-scale mass production PHV two years later. PHVs have the potential to become popular as a realistic solution towards sustainable mobility by renewable electricity usage in the future. (orig.)

  2. How Schools Can Promote Healthy Development for Newly Arrived Immigrant and Refugee Adolescents: Research Priorities

    Science.gov (United States)

    McNeely, Clea A.; Morland, Lyn; Doty, S. Benjamin; Meschke, Laurie L.; Awad, Summer; Husain, Altaf; Nashwan, Ayat

    2017-01-01

    Background: The US education system must find creative and effective ways to foster the healthy development of the approximately 2 million newly arrived immigrant and refugee adolescents, many of whom contend with language barriers, limited prior education, trauma, and discrimination. We identify research priorities for promoting the school…

  3. A computer literacy scale for newly enrolled nursing college students: development and validation.

    Science.gov (United States)

    Lin, Tung-Cheng

    2011-12-01

    Increasing application and use of information systems and mobile technologies in the healthcare industry require increasing nurse competency in computer use. Computer literacy is defined as basic computer skills, whereas computer competency is defined as the computer skills necessary to accomplish job tasks. Inadequate attention has been paid to computer literacy and computer competency scale validity. This study developed a computer literacy scale with good reliability and validity and investigated the current computer literacy of newly enrolled students to develop computer courses appropriate to students' skill levels and needs. This study referenced Hinkin's process to develop a computer literacy scale. Participants were newly enrolled first-year undergraduate students, with nursing or nursing-related backgrounds, currently attending a course entitled Information Literacy and Internet Applications. Researchers examined reliability and validity using confirmatory factor analysis. The final version of the developed computer literacy scale included six constructs (software, hardware, multimedia, networks, information ethics, and information security) and 22 measurement items. Confirmatory factor analysis showed that the scale possessed good content validity, reliability, convergent validity, and discriminant validity. This study also found that participants earned the highest scores for the network domain and the lowest score for the hardware domain. With increasing use of information technology applications, courses related to hardware topic should be increased to improve nurse problem-solving abilities. This study recommends that emphases on word processing and network-related topics may be reduced in favor of an increased emphasis on database, statistical software, hospital information systems, and information ethics.

  4. Newly developed chitosan-silver hybrid nanoparticles: biosafety and apoptosis induction in HepG2 cells

    International Nuclear Information System (INIS)

    El-Sherbiny, Ibrahim M.; Salih, Ehab; Yassin, Abdelrahman M.; Hafez, Elsayed E.

    2016-01-01

    The present study reports the biosafety assessment, the exact molecular effects, and apoptosis induction of newly developed chitosan-silver hybrid nanoparticles (Cs–Ag NPs) in HepG2 cells. The investigated hybrid NPs were green synthesized using Cs/grape leaves aqueous extract (Cs/GLE) or Cs/GLE NPs as reducing and stabilizing agents. The successful formation of Cs/GLE NPs and Cs–Ag hybrid NPs has been confirmed by UV–Vis spectrophotometry, FTIR spectroscopy, XRD, and HRTEM. From the TEM analysis, the prepared Cs/GLE NPs are uniform and spherical with an average size of 150 nm, and the AgNPs (5–10 nm) were formed mainly on their surface. The UV–Vis spectra of Cs–Ag NPs showed a surface plasmon resonance (SPR) peak at about 450 nm confirming their formation. The synthesized Cs–Ag NPs were found to be crystalline as shown by XRD patterns with fcc phase oriented along the (111), (200), (220), and (311) planes. The cytotoxicity patterns, the antiproliferative activities, and the possible mechanisms of anticancer activity at molecular level of the newly developed Cs–Ag hybrid NPs were investigated. Cytotoxicity patterns of all the preparations demonstrated that the nontoxic treatment concentrations are ranged from 0.39 to 50 %, and many of the newly prepared Cs–Ag hybrid NPs showed high anticancer activities against HpG2 cells, and induced cellular apoptosis by downregulating BCL2 gene and upregulating P53.Graphical Abstract

  5. Newly developed chitosan-silver hybrid nanoparticles: biosafety and apoptosis induction in HepG2 cells

    Energy Technology Data Exchange (ETDEWEB)

    El-Sherbiny, Ibrahim M., E-mail: ielsherbiny@Zewailcity.edu.eg; Salih, Ehab [Zewail City of Science and Technology, Center for Materials Science (Egypt); Yassin, Abdelrahman M. [Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technology Applications, Biopharmaceutical Product Research Department (Egypt); Hafez, Elsayed E. [City of Scientific Research and Technology Applications, Plant Protection and Biomolecular Diagnosis Department (Egypt)

    2016-07-15

    The present study reports the biosafety assessment, the exact molecular effects, and apoptosis induction of newly developed chitosan-silver hybrid nanoparticles (Cs–Ag NPs) in HepG2 cells. The investigated hybrid NPs were green synthesized using Cs/grape leaves aqueous extract (Cs/GLE) or Cs/GLE NPs as reducing and stabilizing agents. The successful formation of Cs/GLE NPs and Cs–Ag hybrid NPs has been confirmed by UV–Vis spectrophotometry, FTIR spectroscopy, XRD, and HRTEM. From the TEM analysis, the prepared Cs/GLE NPs are uniform and spherical with an average size of 150 nm, and the AgNPs (5–10 nm) were formed mainly on their surface. The UV–Vis spectra of Cs–Ag NPs showed a surface plasmon resonance (SPR) peak at about 450 nm confirming their formation. The synthesized Cs–Ag NPs were found to be crystalline as shown by XRD patterns with fcc phase oriented along the (111), (200), (220), and (311) planes. The cytotoxicity patterns, the antiproliferative activities, and the possible mechanisms of anticancer activity at molecular level of the newly developed Cs–Ag hybrid NPs were investigated. Cytotoxicity patterns of all the preparations demonstrated that the nontoxic treatment concentrations are ranged from 0.39 to 50 %, and many of the newly prepared Cs–Ag hybrid NPs showed high anticancer activities against HpG2 cells, and induced cellular apoptosis by downregulating BCL2 gene and upregulating P53.Graphical Abstract.

  6. Research and Development Progress of National Key Laboratory of Advanced Composites on Advanced Aeronautical Resin Matrix Composites

    Directory of Open Access Journals (Sweden)

    LI Bintai

    2016-06-01

    Full Text Available Applications and research progress in advanced aeronautical resin matrix composites by National Key Laboratory of Advanced Composites (LAC were summarized. A novel interlaminar toughening technology employing ultra-thin TP non-woven fabric was developed in LAC, which significantly improved the compression after impact (CAI performances of composite laminates.Newly designed multilayer sandwich stealth composite structures exhibited a good broadband radar absorbing properties at 1-18 GHz.There were remarkable developments in high toughness and high temperature resin matrix composites, covering major composite processing technologies such as prepreg-autoclave procedure, liquid composite molding and automation manufacture, etc. Finally, numerical simulation and optimization methods were deliberately utilized in the study of composites curing behavior, resin flow and curing deformation. A composite material database was also established.In conclusion, LAC has been a great support for the development of aeronautical equipment, playing such roles as innovation leading, system dominating, foundation supporting and application ensuring of aerocomposites.

  7. Development of a Modular Laboratory Information Management System (LIMS) for NAA Laboratories Using Open-Source Developing Tools

    International Nuclear Information System (INIS)

    Bounakhla, Moussa; Amsil, Hamid; Embarch, K.; Bounouira, Hamid

    2018-01-01

    CNESTEN designed and developed a modular Laboratory Information Management System (LIMS) for the NAA Laboratory using open-source developing tools. This LIMS ensures a personalized management web space for sample acquisition and preparation, spectra processing and for final analysis of the sample. The system helps also dematerializing process for irradiation requests and for the acquisition of new equipments and samples. It allows managing circulating documents between different actors of the LIMS. Modules for concentration determination, facilities characterization are also included in this LIMS. New modules such as spectra fitting, true coincidence and attenuation corrections can be developed and integrated individually in this system. All data, including nuclear data libraries, are stored in a unique distant database via intranet network to allow instantaneous multi-user access. (author)

  8. Prototype prosperity-diversity game for the Laboratory Development Division of Sandia National Laboratories

    Energy Technology Data Exchange (ETDEWEB)

    VanDevender, P.; Berman, M.; Savage, K.

    1996-02-01

    The Prosperity Game conducted for the Laboratory Development Division of National Laboratories on May 24--25, 1995, focused on the individual and organizational autonomy plaguing the Department of Energy (DOE)-Congress-Laboratories` ability to manage the wrenching change of declining budgets. Prosperity Games are an outgrowth and adaptation of move/countermove and seminar War Games. Each Prosperity Game is unique in that both the game format and the player contributions vary from game to game. This particular Prosperity Game was played by volunteers from Sandia National Laboratories, Eastman Kodak, IBM, and AT&T. Since the participants fully control the content of the games, the specific outcomes will be different when the team for each laboratory, Congress, DOE, and the Laboratory Operating Board (now Laboratory Operations Board) is composed of executives from those respective organizations. Nevertheless, the strategies and implementing agreements suggest that the Prosperity Games stimulate cooperative behaviors and may permit the executives of the institutions to safely explore the consequences of a family of DOE concert.

  9. Biomedical laboratory science education: standardising teaching content in resource-limited countries

    Directory of Open Access Journals (Sweden)

    Wendy Arneson

    2013-06-01

    Full Text Available Background: There is a worldwide shortage of qualified laboratory personnel to provide adequate testing for the detection and monitoring of diseases. In an effort to increase laboratory capacity in developing countries, new skills have been introduced into laboratory services. Curriculum revision with a focus on good laboratory practice is an important aspect of supplying entry-level graduates with the competencies needed to meet the current needs. Objectives: Gaps in application and problem-solving competencies of newly graduated laboratory personnel were discovered in Ethiopia, Tanzania and Kenya. New medical laboratory teaching content was developed in Ethiopia, Tanzania and Kenya using national instructors, tutors, and experts and consulting medical laboratory educators from the United States of America (USA. Method: Workshops were held in Ethiopia to create standardised biomedical laboratory science (BMLS lessons based on recently-revised course objectives with an emphasis on application of skills. In Tanzania, course-module teaching guides with objectives were developed based on established competency outcomes and tasks. In Kenya, example interactive presentations and lesson plans were developed by the USA medical laboratory educators prior to the workshop to serve as resources and templates for the development of lessons within the country itself. Results: The new teaching materials were implemented and faculty, students and other stakeholders reported successful outcomes. Conclusions: These approaches to updating curricula may be helpful as biomedical laboratory schools in other countries address gaps in the competencies of entry-level graduates.

  10. Laboratory Directed Research and Development Annual Report FY 2017

    Energy Technology Data Exchange (ETDEWEB)

    Sullivan, Kelly O.

    2018-03-30

    A national laboratory must establish and maintain an environment in which creativity and innovation are encouraged and supported in order to fulfill its missions and remain viable in the long term. As such, multiprogram laboratories are given discretion to allocate a percentage of their operating budgets to support research and development projects that align to PNNL’s and DOE’s missions and support the missions of other federal agencies, including DHS, DOD, and others. DOE Order 413.2C sets forth DOE’s Laboratory Directed Research and Development (LDRD) policy and guidelines for DOE multiprogram laboratories, and it authorizes the national laboratories to allocate up to 6 percent of their operating budgets to fund the program. LDRD is innovative research and development, selected by the Laboratory Director or his/her designee, for the purpose of maintaining the scientific and technological vitality of the Laboratory. The projects supported by LDRD funding all have demonstrable ties to DOE/DHS missions and may also be relevant to the missions of other federal agencies that sponsor work at the Laboratory. The program plays a key role in attracting the best and brightest scientific staff, which is needed to serve the highest priority DOE mission objectives. Individual project reports comprise the bulk of this LDRD report. The Laboratory focuses its LDRD research on scientific assets that often address more than one scientific discipline.

  11. Laboratory Directed Research and Development Annual Report FY 2016

    Energy Technology Data Exchange (ETDEWEB)

    Sullivan, Kelly O. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2017-03-30

    A national laboratory must establish and maintain an environment in which creativity and innovation are encouraged and supported in order to fulfill its missions and remain viable in the long term. As such, multiprogram laboratories are given discretion to allocate a percentage of their operating budgets to support research and development projects that align to PNNL’s and DOE’s missions and support the missions of other federal agencies, including DHS, DOD, and others. DOE Order 413.2C sets forth DOE’s Laboratory Directed Research and Development (LDRD) policy and guidelines for DOE multiprogram laboratories, and it authorizes the national laboratories to allocate up to 6 percent of their operating budgets to fund the program. LDRD is innovative research and development, selected by the Laboratory Director or his/her designee, for the purpose of maintaining the scientific and technological vitality of the Laboratory. The projects supported by LDRD funding all have demonstrable ties to DOE/DHS missions and may also be relevant to the missions of other federal agencies that sponsor work at the Laboratory. The program plays a key role in attracting the best and brightest scientific staff, which is needed to serve the highest priority DOE mission objectives. Individual project reports comprise the bulk of this LDRD report. The Laboratory focuses its LDRD research on scientific assets that often address more than one scientific discipline.

  12. Development and Manufacture of the Nuclear Laboratory Equipment

    International Nuclear Information System (INIS)

    Youm, Ki Un; Kim, J. K.; Kim, K. S.; Lee, I. B.; Youm, J. H.; Park, I. W.

    2008-12-01

    This report on development and manufacture of the nuclear laboratory equipment contains the work scope and contents performed for supporting the researches and the developments projects efficiently. And also, the records for the principal production design, the manufacture contents, the working drawings and the CNC program are described in it. Most of works are to support the successful and convenient performance of the R and D projects by development and manufacturing the requested laboratory equipment

  13. Development and Manufacture of the Nuclear Laboratory Equipment

    International Nuclear Information System (INIS)

    Youm, Ki Un; Moon, J. S.; Lee, I. B.; Youn, J. H.

    2010-12-01

    This report on development and manufacture of the nuclear laboratory equipment contains the work scope and contents performed for supporting the researches and the developments projects efficiently. And also, the records for the principal production design, the manufacture contents, the working drawings and the CNC program are described in it. Most of works are to support the successful and convenient performance of the R and D projects by development and manufacturing the requested laboratory equipment

  14. Development and Manufacture of the Nuclear laboratory equipment

    International Nuclear Information System (INIS)

    Youm, Ki Un; Lee, I. B.; Youm, J. H.

    2009-12-01

    This report on development and manufacture of the nuclear laboratory equipment contains the work scope and contents performed for supporting the researches and the developments projects efficiently. And also, the records for the principal production design, the manufacture contents, the working drawings and the CNC program are described in it. Most of works are to support the successful and convenient performance of the R and D projects by development and manufacturing the requested laboratory equipment

  15. Muscle Attenuation Is Associated With Newly Developed Hypertension in Men of African Ancestry.

    Science.gov (United States)

    Zhao, Qian; Zmuda, Joseph M; Kuipers, Allison L; Bunker, Clareann H; Patrick, Alan L; Youk, Ada O; Miljkovic, Iva

    2017-05-01

    Increased ectopic adipose tissue infiltration in skeletal muscle is associated with insulin resistance and diabetes mellitus. We evaluated whether change in skeletal muscle adiposity predicts subsequent development of hypertension in men of African ancestry, a population sample understudied in previous studies. In the Tobago Health Study, a prospective longitudinal study among men of African ancestry (age range 40-91 years), calf intermuscular adipose tissue, and skeletal muscle attenuation were measured with computed tomography. Hypertension was defined as a systolic blood pressure ≥140 mm Hg, or a diastolic blood pressure ≥90 mm Hg, or receiving antihypertensive medications. Logistic regression was performed with adjustment for age, insulin resistance, baseline and 6-year change in body mass index, baseline and 6-year change in waist circumference, and other potential confounding factors. Among 746 normotensive men at baseline, 321 (43%) developed hypertension during the mean 6.2 years of follow-up. Decreased skeletal muscle attenuation was associated with newly developed hypertension after adjustment for baseline and 6-year change of body mass index (odds ratio [95% confidence interval] per SD, 1.3 [1.0-1.6]) or baseline and 6-year change of waist circumference (odds ratio [95% confidence interval] per SD, 1.3 [1.0-1.6]). No association was observed between increased intermuscular adipose tissue and hypertension. Our novel findings show that decreased muscle attenuation is associated with newly developed hypertension among men of African ancestry, independent of general and central adiposity and insulin resistance. Further studies are needed to adjust for inflammation, visceral and other ectopic adipose tissue depots, and to confirm our findings in other population samples. © 2017 American Heart Association, Inc.

  16. Laboratory Directed Research and Development FY-10 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Dena Tomchak

    2011-03-01

    The FY 2010 Laboratory Directed Research and Development (LDRD) Annual Report is a compendium of the diverse research performed to develop and ensure the INL's technical capabilities can support the future DOE missions and national research priorities. LDRD is essential to the INL -- it provides a means for the laboratory to pursue novel scientific and engineering research in areas that are deemed too basic or risky for programmatic investments. This research enhances technical capabilities at the laboratory, providing scientific and engineering staff with opportunities for skill building and partnership development.

  17. Laboratory Directed Research and Development Program. Annual report

    Energy Technology Data Exchange (ETDEWEB)

    Ogeka, G.J.

    1991-12-01

    Today, new ideas and opportunities, fostering the advancement of technology, are occurring at an ever-increasing rate. It, therefore, seems appropriate that a vehicle be available which fosters the development of these new ideas and technologies, promotes the early exploration and exploitation of creative and innovative concepts, and which develops new ``fundable`` R&D projects and programs. At Brookhaven National Laboratory (BNL), one such method is through its Laboratory Directed Research and Development (LDRD) Program. This discretionary research and development tool is critical in maintaining the scientific excellence and vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor achieving and maintaining staff excellence, and a means to address national needs, with the overall mission of the Department of Energy (DOE) and the Brookhaven National Laboratory. The Project Summaries with their accomplishments described in this report reflect the above. Aside from leading to new fundable or promising programs and producing especially noteworthy research, they have resulted in numerous publications in various professional and scientific journals, and presentations at meetings and forums.

  18. Laboratory Directed Research and Development annual report, fiscal year 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    The Department of Energy Order 413.2(a) establishes DOE`s policy and guidelines regarding Laboratory Directed Research and Development (LDRD) at its multiprogram laboratories. As described in 413.2, LDRD is research and development of a creative and innovative nature which is selected by the Laboratory Director or his or her designee, for the purpose of maintaining the scientific and technological vitality of the Laboratory and to respond to scientific and technological opportunities in conformance with the guidelines in this Order. DOE Order 413.2 requires that each laboratory submit an annual report on its LDRD activities to the cognizant Secretarial Officer through the appropriate Operations Office Manager. The report provided in this document represents Pacific Northwest National Laboratory`s LDRD report for FY 1997.

  19. The Development of Laboratory Safety Questionnaire for Middle School Science Teachers

    Science.gov (United States)

    Akpullukcu, Simge; Cavas, Bulent

    2017-01-01

    The purpose of this paper is to develop a "valid and reliable laboratory safety questionnaire" which could be used to identify science teachers' understanding about laboratory safety issues during their science laboratory activities. The questionnaire was developed from a literature review and prior instruments developed on laboratory…

  20. Predictive score for the development or progression of Graves' orbitopathy in patients with newly diagnosed Graves' hyperthyroidism

    DEFF Research Database (Denmark)

    Wiersinga, Wilmar; Žarković, Miloš; Bartalena, Luigi

    2018-01-01

    OBJECTIVE: To construct a predictive score for the development or progression of Graves' orbitopathy (GO) in Graves' hyperthyroidism (GH). DESIGN: Prospective observational study in patients with newly diagnosed GH, treated with antithyroid drugs (ATD) for 18 months at ten participating centers f...

  1. Argonne National Laboratory Annual Report of Laboratory Directed Research and Development program activities FY 2011.

    Energy Technology Data Exchange (ETDEWEB)

    (Office of The Director)

    2012-04-25

    As a national laboratory Argonne concentrates on scientific and technological challenges that can only be addressed through a sustained, interdisciplinary focus at a national scale. Argonne's eight major initiatives, as enumerated in its strategic plan, are Hard X-ray Sciences, Leadership Computing, Materials and Molecular Design and Discovery, Energy Storage, Alternative Energy and Efficiency, Nuclear Energy, Biological and Environmental Systems, and National Security. The purposes of Argonne's Laboratory Directed Research and Development (LDRD) Program are to encourage the development of novel technical concepts, enhance the Laboratory's research and development (R and D) capabilities, and pursue its strategic goals. projects are selected from proposals for creative and innovative R and D studies that require advance exploration before they are considered to be sufficiently developed to obtain support through normal programmatic channels. Among the aims of the projects supported by the LDRD Program are the following: establishment of engineering proof of principle, assessment of design feasibility for prospective facilities, development of instrumentation or computational methods or systems, and discoveries in fundamental science and exploratory development.

  2. Argonne National Laboratory Annual Report of Laboratory Directed Research and Development program activities FY 2010.

    Energy Technology Data Exchange (ETDEWEB)

    (Office of The Director)

    2012-04-25

    As a national laboratory Argonne concentrates on scientific and technological challenges that can only be addressed through a sustained, interdisciplinary focus at a national scale. Argonne's eight major initiatives, as enumerated in its strategic plan, are Hard X-ray Sciences, Leadership Computing, Materials and Molecular Design and Discovery, Energy Storage, Alternative Energy and Efficiency, Nuclear Energy, Biological and Environmental Systems, and National Security. The purposes of Argonne's Laboratory Directed Research and Development (LDRD) Program are to encourage the development of novel technical concepts, enhance the Laboratory's research and development (R and D) capabilities, and pursue its strategic goals. projects are selected from proposals for creative and innovative R and D studies that require advance exploration before they are considered to be sufficiently developed to obtain support through normal programmatic channels. Among the aims of the projects supported by the LDRD Program are the following: establishment of engineering proof of principle, assessment of design feasibility for prospective facilities, development of instrumentation or computational methods or systems, and discoveries in fundamental science and exploratory development.

  3. Pressure drop performance evaluation for test assemblies with the newly developed top and bottom nozzles

    International Nuclear Information System (INIS)

    Lee, S. K.; Park, N. K.; Su, J. M.; Kim, H. K.; Lee, J. N.; Kim, K. T.

    2003-01-01

    To perform the hydraulic test for the newly developed top and bottom nozzles, two kinds of test assemblies were manufactured i. e. one is the test assembly which has the newly developed top and bottom nozzles and the other is Guardian test assembly which is commercially in mass production now. The test results show that the test assembly with one top nozzle and two bottom nozzles has a greater pressure loss coefficient than Guardian test assembly by 60.9% and 90.4% at the bottom nozzle location. This cause is due to the debris filtering plate for bottom nozzle to improve a filtering efficiency aginst foreign material. In the region of mid grid and top nozzle, there is no difference in pressure loss coefficient between the test assemblies since the componet features in these regions are very similar or same each other. The loss coefficients are 14.2% and 21.9% for model A and B respectively in the scale of test assembly, and the value would be within the 10% in the scale of real fuel assembly. As a result of hydraulic performance evaluation, model A is superior to model B

  4. How Schools Can Promote Healthy Development for Newly Arrived Immigrant and Refugee Adolescents: Research Priorities.

    Science.gov (United States)

    McNeely, Clea A; Morland, Lyn; Doty, S Benjamin; Meschke, Laurie L; Awad, Summer; Husain, Altaf; Nashwan, Ayat

    2017-02-01

    The US education system must find creative and effective ways to foster the healthy development of the approximately 2 million newly arrived immigrant and refugee adolescents, many of whom contend with language barriers, limited prior education, trauma, and discrimination. We identify research priorities for promoting the school success of these youth. The study used the 4-phase priority-setting method of the Child Health and Nutrition Research Initiative. In the final stage, 132 researchers, service providers, educators, and policymakers based in the United States were asked to rate the importance of 36 research options. The highest priority research options (range 1 to 5) were: evaluating newcomer programs (mean = 4.44, SD = 0.55), identifying how family and community stressors affect newly arrived immigrant and refugee adolescents' functioning in school (mean = 4.40, SD = 0.56), identifying teachers' major stressors in working with this population (mean = 4.36, SD = 0.72), and identifying how to engage immigrant and refugee families in their children's education (mean = 4.35, SD = 0.62). These research priorities emphasize the generation of practical knowledge that could translate to immediate, tangible benefits for schools. Funders, schools, and researchers can use these research priorities to guide research for the highest benefit of schools and the newly arrived immigrant and refugee adolescents they serve. © 2017, American School Health Association.

  5. Laboratory Directed Research and Development FY 2000

    International Nuclear Information System (INIS)

    Hansen, Todd; Levy, Karin

    2001-01-01

    The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab or LBNL) is a multi-program national research facility operated by the University of California for the Department of Energy (DOE). As an integral element of DOE's National Laboratory System, Berkeley Lab supports DOE's missions in fundamental science, energy resources, and environmental quality. Berkeley Lab programs advance four distinct goals for DOE and the nation: (1) To perform leading multidisciplinary research in the computing sciences, physical sciences, energy sciences, biosciences, and general sciences in a manner that ensures employee and public safety and protection of the environment. (2) To develop and operate unique national experimental facilities for qualified investigators. (3) To educate and train future generations of scientists and engineers to promote national science and education goals. (4) To transfer knowledge and technological innovations and to foster productive relationships among Berkeley Lab's research programs, universities, and industry in order to promote national economic competitiveness. Annual report on Laboratory Directed Research and Development for FY2000

  6. Laboratory robotics projects in the Analytical Development Division at the Savannah River Laboratory

    International Nuclear Information System (INIS)

    Lien, O.G.; Steele, A.W.

    1986-01-01

    To encourage the application of robotics technology for routine radiobench applications, a laboratory dedicated to the research and development of contained robotic systems is being constructed. The facility will have several robots located in laminar flow hoods, and the hoods are being designed to allow the possibility for multiple robots to work together. This paper presents both the design features of the hoods and the general layout of the laboratory, and also discusses an application of a robotic system for the routine nuclear counting of gamma tube samples. The gamma tube system is presently operating in one of the routine analysis laboratories. 5 figs

  7. A multi-method approach to curriculum development for in-service training in China's newly established health emergency response offices.

    Directory of Open Access Journals (Sweden)

    Yadong Wang

    Full Text Available To describe an innovative approach for developing and implementing an in-service curriculum in China for staff of the newly established health emergency response offices (HEROs, and that is generalisable to other settings.The multi-method training needs assessment included reviews of the competency domains needed to implement the International Health Regulations (2005 as well as China's policies and emergency regulations. The review, iterative interviews and workshops with experts in government, academia, the military, and with HERO staff were reviewed critically by an expert technical advisory panel.Over 1600 participants contributed to curriculum development. Of the 18 competency domains identified as essential for HERO staff, nine were developed into priority in-service training modules to be conducted over 2.5 weeks. Experts from academia and experienced practitioners prepared and delivered each module through lectures followed by interactive problem-solving exercises and desktop simulations to help trainees apply, experiment with, and consolidate newly acquired knowledge and skills.This study adds to the emerging literature on China's enduring efforts to strengthen its emergency response capabilities since the outbreak of SARS in 2003. The multi-method approach to curriculum development in partnership with senior policy-makers, researchers, and experienced practitioners can be applied in other settings to ensure training is responsive and customized to local needs, resources and priorities. Ongoing curriculum development should reflect international standards and be coupled with the development of appropriate performance support systems at the workplace for motivating staff to apply their newly acquired knowledge and skills effectively and creatively.

  8. A multi-method approach to curriculum development for in-service training in China's newly established health emergency response offices.

    Science.gov (United States)

    Wang, Yadong; Li, Xiangrui; Yuan, Yiwen; Patel, Mahomed S

    2014-01-01

    To describe an innovative approach for developing and implementing an in-service curriculum in China for staff of the newly established health emergency response offices (HEROs), and that is generalisable to other settings. The multi-method training needs assessment included reviews of the competency domains needed to implement the International Health Regulations (2005) as well as China's policies and emergency regulations. The review, iterative interviews and workshops with experts in government, academia, the military, and with HERO staff were reviewed critically by an expert technical advisory panel. Over 1600 participants contributed to curriculum development. Of the 18 competency domains identified as essential for HERO staff, nine were developed into priority in-service training modules to be conducted over 2.5 weeks. Experts from academia and experienced practitioners prepared and delivered each module through lectures followed by interactive problem-solving exercises and desktop simulations to help trainees apply, experiment with, and consolidate newly acquired knowledge and skills. This study adds to the emerging literature on China's enduring efforts to strengthen its emergency response capabilities since the outbreak of SARS in 2003. The multi-method approach to curriculum development in partnership with senior policy-makers, researchers, and experienced practitioners can be applied in other settings to ensure training is responsive and customized to local needs, resources and priorities. Ongoing curriculum development should reflect international standards and be coupled with the development of appropriate performance support systems at the workplace for motivating staff to apply their newly acquired knowledge and skills effectively and creatively.

  9. THE RELATIONSHIP BETWEEN MASS OF NEWLY HATCHED INDIVIDUALS AND COCOON MASS IN LUMBRICID EARTHWORMS

    DEFF Research Database (Denmark)

    Bruus, Marianne; Bjerre, Arne

    1991-01-01

    Earthworm cocoons from laboratory cultures were collected and their mass was determined. When hatched, the mass of the young worms was found. Cocoon mass and the mass of hatchlings varied considerably within species. The hygromass of newly hatched earthworms was found to correlate linearly...

  10. Study on development of virtual reactor core laboratory (1). Development of prototype coupled neutronic, thermal-hydraulic and structural analysis system

    International Nuclear Information System (INIS)

    Uto, Nariaki; Sugaya, Toshio; Tsukimori, Kazuyuki; Negishi, Hitoshi; Enuma, Yasuhiro; Sakai, Takaaki

    1999-09-01

    A study on development of virtual reactor core laboratory, which is to conduct numerical experiments representative of complicated physical phenomena in practical reactor core systems on a computational environment, has progressed at Japan Nuclear Cycle Development Institute (JNC). The study aims at systematic evaluation of these phenomena into which nuclear reactions, thermal-hydraulic characteristics, structural responses and fuel behaviors combine, and effective utilization of the obtained comprehension for core design. This report presents a production of a prototype computational system which is required to construct the virtual reactor core laboratory. This system is to evaluate reactor core performance under the coupled neutronic, thermal-hydraulic and structural phenomena, and is composed of two analysis tools connected by a newly developed interface program; 1) an existing space-dependent coupled neutronic and thermal-hydraulic analysis system arranged at JNC and 2) a core deformation analysis code. It acts on a cluster of several DEC/Alpha workstations. A specific library called MPI1 (Message Passing Interface 1) is incorporated as a tool for communicating among the analysis modules consisting of the system. A series of calculations for simulating a sequence of Unprotected Loss Of Heat Sink (ULOHS) coupled with rapid drop of some neutron absorber devices in a prototype fast reactor is tried to investigate how the system works. The obtained results show the core deformation behavior followed by the reactivity change that can be properly evaluated. The results of this report show that the system is expected to be useful for analyzing sensitivity of reactor core performance with respect to uncertainties of various design parameters and establishing a concept of passive safety reactor system, taking into account space distortion of neutron flux distribution during abnormal events as well as reactivity feedback from core deformation. (author)

  11. 1995 Laboratory-Directed Research and Development Annual report

    International Nuclear Information System (INIS)

    Cauffman, D.P.; Shoaf, D.L.; Hill, D.A.; Denison, A.B.

    1995-01-01

    The Laboratory-Directed Research and Development Program (LDRD) is a key component of the discretionary research conducted by Lockheed Idaho Technologies Company (Lockheed Idaho) at the Idaho National Engineering Laboratory (INEL). The threefold purpose and goal of the LDRD program is to maintain the scientific and technical vitality of the INEL, respond to and support new technical opportunities, and enhance the agility and flexibility of the national laboratory and Lockheed Idaho to address the current and future missions of the Department of Energy

  12. 1995 Laboratory-Directed Research and Development Annual report

    Energy Technology Data Exchange (ETDEWEB)

    Cauffman, D.P.; Shoaf, D.L.; Hill, D.A.; Denison, A.B.

    1995-12-31

    The Laboratory-Directed Research and Development Program (LDRD) is a key component of the discretionary research conducted by Lockheed Idaho Technologies Company (Lockheed Idaho) at the Idaho National Engineering Laboratory (INEL). The threefold purpose and goal of the LDRD program is to maintain the scientific and technical vitality of the INEL, respond to and support new technical opportunities, and enhance the agility and flexibility of the national laboratory and Lockheed Idaho to address the current and future missions of the Department of Energy.

  13. Argonne National Laboratory Annual Report of Laboratory Directed Research and Development Program Activities for FY 1994

    Energy Technology Data Exchange (ETDEWEB)

    None

    1995-02-25

    The purposes of Argonne's Laboratory Directed Research and Development (LDRD) Program are to encourage the development of novel concepts, enhance the Laboratory's R and D capabilities, and further the development of its strategic initiatives. Projects are selected from proposals for creative and innovative R and D studies which are not yet eligible for timely support through normal programmatic channels. Among the aims of the projects supported by the Program are establishment of engineering proof-of-principle; assessment of design feasibility for prospective facilities; development of an instrumental prototype, method, or system; or discovery in fundamental science. Several of these projects are closely associated with major strategic thrusts of the Laboratory as described in Argonne's Five-Year Institutional Plan, although the scientific implications of the achieved results extend well beyond Laboratory plans and objectives. The projects supported by the Program are distributed across the major programmatic areas at Argonne as indicated in the Laboratory's LDRD Plan for FY 1994. Project summaries of research in the following areas are included: (1) Advanced Accelerator and Detector Technology; (2) X-ray Techniques for Research in Biological and Physical Science; (3) Nuclear Technology; (4) Materials Science and Technology; (5) Computational Science and Technology; (6) Biological Sciences; (7) Environmental Sciences: (8) Environmental Control and Waste Management Technology; and (9) Novel Concepts in Other Areas.

  14. Oak Ridge National Laboratory Office of International Nuclear Safeguards: Human Capital Development Activity in FY16

    International Nuclear Information System (INIS)

    Gilligan, Kimberly V.; Gaudet, Rachel N.

    2016-01-01

    In 2007, the U.S. Department of Energy National Nuclear Security Administration (DOE NNSA) Office of Nonproliferation and Arms Control (NPAC) completed a comprehensive review of the current and potential future challenges facing the international safeguards system. One of the report's key recommendations was for DOE NNSA to launch a major new program to revitalize the international safeguards technology and human resource base. In 2007, at the International Atomic Energy Agency (IAEA) General Conference, then Secretary of Energy Samuel W. Bodman announced the newly created Next Generation Safeguards Initiative (NGSI). NGSI consists of five program elements: policy development and outreach, concepts and approaches, technology and analytical methodologies, human capital development (HCD), and infrastructure development. This report addresses the HCD component of NGSI. The goal of the HCD component as defined in the NNSA Program Plan is ''to revitalize and expand the international safeguards human capital base by attracting and training a new generation of talent.'' The major objectives listed in the HCD goal include education and training, outreach to universities and professional societies, postdoctoral appointments, and summer internships at national laboratories.

  15. Oak Ridge National Laboratory Office of International Nuclear Safeguards: Human Capital Development Activity in FY16

    Energy Technology Data Exchange (ETDEWEB)

    Gilligan, Kimberly V. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Nuclear Security and Isotope Technology Division; Gaudet, Rachel N. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Nuclear Security and Isotope Technology Division

    2016-09-30

    In 2007, the U.S. Department of Energy National Nuclear Security Administration (DOE NNSA) Office of Nonproliferation and Arms Control (NPAC) completed a comprehensive review of the current and potential future challenges facing the international safeguards system. One of the report’s key recommendations was for DOE NNSA to launch a major new program to revitalize the international safeguards technology and human resource base. In 2007, at the International Atomic Energy Agency (IAEA) General Conference, then Secretary of Energy Samuel W. Bodman announced the newly created Next Generation Safeguards Initiative (NGSI). NGSI consists of five program elements: policy development and outreach, concepts and approaches, technology and analytical methodologies, human capital development (HCD), and infrastructure development. This report addresses the HCD component of NGSI. The goal of the HCD component as defined in the NNSA Program Plan is “to revitalize and expand the international safeguards human capital base by attracting and training a new generation of talent.” The major objectives listed in the HCD goal include education and training, outreach to universities and professional societies, postdoctoral appointments, and summer internships at national laboratories.

  16. LABORATORY DIRECTED RESEARCH AND DEVELOPMENT PROGRAM ASSESSMENT FOR FY 2006.

    Energy Technology Data Exchange (ETDEWEB)

    FOX,K.J.

    2006-01-01

    Brookhaven National Laboratory (BNL) is a multidisciplinary laboratory that carries out basic and applied research in the physical, biomedical, and environmental sciences, and in selected energy technologies. It is managed by Brookhaven Science Associates, LLC, (BSA) under contract with the U. S. Department of Energy (DOE). BNL's total annual budget has averaged about $460 million. There are about 2,500 employees, and another 4,500 guest scientists and students who come each year to use the Laboratory's facilities and work with the staff. The BNL Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) annually in March, as required by DOE Order 413.2B, ''Laboratory Directed Research and Development,'' April 19,2006, and the Roles, Responsibilities, and Guidelines for Laboratory Directed Research and Development at the Department of Energy National Nuclear Security Administration Laboratories dated June 13,2006. The goals and' objectives of BNL's LDRD Program can be inferred from the Program's stated purposes. These are to (1) encourage and support the development of new ideas and technology, (2) promote the early exploration and exploitation of creative and innovative concepts, and (3) develop new ''fundable'' R&D projects and programs. The emphasis is clearly articulated by BNL to be on supporting exploratory research ''which could lead to new programs, projects, and directions'' for the Laboratory. As one of the premier scientific laboratories of the DOE, BNL must continuously foster groundbreaking scientific research. At Brookhaven National Laboratory one such method is through its LDRD Program. This discretionary research and development tool is critical in maintaining the scientific excellence and long-term vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community and foster new

  17. Laboratory Directed Research and Development Program Assessment for FY 2007

    Energy Technology Data Exchange (ETDEWEB)

    Newman,L.; Fox, K.J.

    2007-12-31

    Brookhaven National Laboratory (BNL) is a multidisciplinary laboratory that carries out basic and applied research in the physical, biomedical, and environmental sciences, and in selected energy technologies. It is managed by Brookhaven Science Associates, LLC, (BSA) under contract with the U. S. Department of Energy (DOE). BNL's Fiscal Year 2007 spending was $515 million. There are approximately 2,600 employees, and another 4,500 guest scientists and students who come each year to use the Laboratory's facilities and work with the staff. The BNL Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) annually in March, as required by DOE Order 413.2B, 'Laboratory Directed Research and Development', April 19, 2006, and the Roles, Responsibilities, and Guidelines for Laboratory Directed Research and Development at the Department of Energy/National Nuclear Security Administration Laboratories dated June 13, 2006. The goals and objectives of BNL's LDRD Program can be inferred from the Program's stated purposes. These are to (1) encourage and support the development of new ideas and technology, (2) promote the early exploration and exploitation of creative and innovative concepts, and (3) develop new 'fundable' R&D projects and programs. The emphasis is clearly articulated by BNL to be on supporting exploratory research 'which could lead to new programs, projects, and directions' for the Laboratory. As one of the premier scientific laboratories of the DOE, BNL must continuously foster groundbreaking scientific research. At Brookhaven National Laboratory one such method is through its LDRD Program. This discretionary research and development tool is critical in maintaining the scientific excellence and long-term vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community and foster new science and technology ideas, which

  18. Laboratory Directed Research and Development FY 1998 Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    John Vigil; Kyle Wheeler

    1999-04-01

    This is the FY 1998 Progress Report for the Laboratory Directed Research and Development (LDRD) Program at Los Alamos National Laboratory. It gives an overview of the LDRD Program, summarizes work done on individual research projects, relates the projects to major Laboratory program sponsors, and provides an index to the principle investigators. Project summaries are grouped by their LDRD component: Competency Development, Program Development, and Individual Projects. Within each component, they are further grouped into nine technical categories: (1) materials science, (2) chemistry, (3) mathematics and computational science, (4) atomic, molecular, optical, and plasma physics, fluids, and particle beams, (5) engineering science, (6) instrumentation and diagnostics, (7) geoscience, space science, and astrophysics, (8) nuclear and particle physics, and (9) bioscience.

  19. Laboratory directed research and development: FY 1997 progress report

    Energy Technology Data Exchange (ETDEWEB)

    Vigil, J.; Prono, J. [comps.

    1998-05-01

    This is the FY 1997 Progress Report for the Laboratory Directed Research and Development (LDRD) program at Los Alamos National Laboratory. It gives an overview of the LDRD program, summarizes work done on individual research projects, relates the projects to major Laboratory program sponsors, and provides an index to the principal investigators. Project summaries are grouped by their LDRD component: Competency Development, Program Development, and Individual Projects. Within each component, they are further grouped into nine technical categories: (1) materials science, (2) chemistry, (3) mathematics and computational science, (4) atomic and molecular physics and plasmas, fluids, and particle beams, (5) engineering science, (6) instrumentation and diagnostics, (7) geoscience, space science, and astrophysics, (8) nuclear and particle physics, and (9) bioscience.

  20. Development of a laboratory niche Web site.

    Science.gov (United States)

    Dimenstein, Izak B; Dimenstein, Simon I

    2013-10-01

    This technical note presents the development of a methodological laboratory niche Web site. The "Grossing Technology in Surgical Pathology" (www.grossing-technology.com) Web site is used as an example. Although common steps in creation of most Web sites are followed, there are particular requirements for structuring the template's menu on methodological laboratory Web sites. The "nested doll principle," in which one object is placed inside another, most adequately describes the methodological approach to laboratory Web site design. Fragmentation in presenting the Web site's material highlights the discrete parts of the laboratory procedure. An optimally minimal triad of components can be recommended for the creation of a laboratory niche Web site: a main set of media, a blog, and an ancillary component (host, contact, and links). The inclusion of a blog makes the Web site a dynamic forum for professional communication. By forming links and portals, cloud computing opens opportunities for connecting a niche Web site with other Web sites and professional organizations. As an additional source of information exchange, methodological laboratory niche Web sites are destined to parallel both traditional and new forms, such as books, journals, seminars, webinars, and internal educational materials. Copyright © 2013 Elsevier Inc. All rights reserved.

  1. Association Between Manual Loading and Newly Developed Carpal Tunnel Syndrome in Subjects With Physical Disabilities: A Follow-Up Study.

    Science.gov (United States)

    Lin, Yen-Nung; Chiu, Chun-Chieh; Huang, Shih-Wei; Hsu, Wen-Yen; Liou, Tsan-Hon; Chen, Yi-Wen; Chang, Kwang-Hwa

    2017-10-01

    To identify the association between body composition and newly developed carpal tunnel syndrome (CTS) and to search for the best probabilistic cutoff value of associated factors to predict subjects with physical disabilities developing new CTS. Longitudinal. University-affiliated medical center. Subjects with physical disabilities (N=47; mean age ± SD, 42.1±7.7y). Not applicable. Median and ulnar sensory nerve conduction velocity (SNCV) were measured at the initial and follow-up tests (interval >2y). Total and regional body composition were measured with dual-energy x-ray absorptiometry at the initial test. Leg lean tissue percentage was calculated to delineate each participant's manual loading degree during locomotion. Leg lean tissue percentage is the lean tissue mass of both legs divided by body weight. Based on median SNCV changes, we divided all participants into 3 groups: subjects with bilateral CTS (median SNCV value normative ulnar SNCV value >37.8m/s) in the initial test (n=10), subjects with newly developed CTS in the follow-up test (n=8), and subjects without additional CTS in the follow-up test (n=27). Eight of 35 subjects not having bilateral CTS initially developed new CTS (8.8% per year; mean follow-up period, 2.6y). Leg lean tissue percentage was associated with the probability of newly developed CTS (adjusted odds ratio, .64; P12% were less likely to have developed new CTS at the follow-up test (sensitivity, .75; specificity, .85; area under the curve, .88; Pphysical disabilities. Therefore, a preventive program for those subjects at risk can start early. Copyright © 2017 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  2. Development of a new virtual nuclear reactor laboratory

    International Nuclear Information System (INIS)

    Ahmad Abrishami; Ali Pazirandeh

    2009-01-01

    Full text: Nowadays the education industry benefits from computer programs and software in various ways as well as many other industries. Here the e-learning technology uses some forms of software platform to present its contents. Virtual laboratories are superior tools in this technology. A virtual laboratory is interactive graphical user interface software that is based on known scientific laws of its virtual elements, which responses to user acts as desired in the real case. There are some known commercial and non-commercial ones. There are also some simulation software in the field of nuclear industry that has some uses in operator learning and some other applications such as analyzing the effects of human mistakes on plant safety. In this paper we discuss more about the ways to develop a virtual nuclear reactor laboratory and propose our first release of such tool. Our target reactor is Tehran Research Reactor (TRR), which is a pool type reactor. We used WIMS and COSTANZA to develop the simulator kernel of virtual laboratory. (Author)

  3. Laboratory Directed Research and Development Program FY 2006 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Sjoreen, Terrence P [ORNL

    2007-04-01

    The Oak Ridge National Laboratory (ORNL) Laboratory Directed Research and Development (LDRD) Program reports its status to the US Departmental of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, 'Laboratory Directed Research and Development' (April 19, 2006), which establishes DOE's requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries all ORNL LDRD research activities supported during FY 2006. The associated FY 2006 ORNL LDRD Self-Assessment (ORNL/PPA-2007/2) provides financial data about the FY 2006 projects and an internal evaluation of the program's management process.

  4. Newly Discovered Ebola Virus Associated with Hemorrhagic Fever Outbreak in Uganda

    Science.gov (United States)

    Towner, Jonathan S.; Sealy, Tara K.; Khristova, Marina L.; Albariño, César G.; Conlan, Sean; Reeder, Serena A.; Quan, Phenix-Lan; Lipkin, W. Ian; Downing, Robert; Tappero, Jordan W.; Okware, Samuel; Lutwama, Julius; Bakamutumaho, Barnabas; Kayiwa, John; Comer, James A.; Rollin, Pierre E.; Ksiazek, Thomas G.; Nichol, Stuart T.

    2008-01-01

    Over the past 30 years, Zaire and Sudan ebolaviruses have been responsible for large hemorrhagic fever (HF) outbreaks with case fatalities ranging from 53% to 90%, while a third species, Côte d'Ivoire ebolavirus, caused a single non-fatal HF case. In November 2007, HF cases were reported in Bundibugyo District, Western Uganda. Laboratory investigation of the initial 29 suspect-case blood specimens by classic methods (antigen capture, IgM and IgG ELISA) and a recently developed random-primed pyrosequencing approach quickly identified this to be an Ebola HF outbreak associated with a newly discovered ebolavirus species (Bundibugyo ebolavirus) distantly related to the Côte d'Ivoire ebolavirus found in western Africa. Due to the sequence divergence of this new virus relative to all previously recognized ebolaviruses, these findings have important implications for design of future diagnostic assays to monitor Ebola HF disease in humans and animals, and ongoing efforts to develop effective antivirals and vaccines. PMID:19023410

  5. Laboratory Directed Research and Development FY 2000

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Todd; Levy, Karin

    2001-02-27

    The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab or LBNL) is a multi-program national research facility operated by the University of California for the Department of Energy (DOE). As an integral element of DOE's National Laboratory System, Berkeley Lab supports DOE's missions in fundamental science, energy resources, and environmental quality. Berkeley Lab programs advance four distinct goals for DOE and the nation: (1) To perform leading multidisciplinary research in the computing sciences, physical sciences, energy sciences, biosciences, and general sciences in a manner that ensures employee and public safety and protection of the environment. (2) To develop and operate unique national experimental facilities for qualified investigators. (3) To educate and train future generations of scientists and engineers to promote national science and education goals. (4) To transfer knowledge and technological innovations and to foster productive relationships among Berkeley Lab's research programs, universities, and industry in order to promote national economic competitiveness. Annual report on Laboratory Directed Research and Development for FY2000.

  6. Public health laboratory quality management in a developing country.

    Science.gov (United States)

    Wangkahat, Khwanjai; Nookhai, Somboon; Pobkeeree, Vallerut

    2012-01-01

    The article aims to give an overview of the system of public health laboratory quality management in Thailand and to produce a strengths, weaknesses, opportunities and threats (SWOT) analysis that is relevant to public health laboratories in the country. The systems for managing laboratory quality that are currently employed were described in the first component. The second component was a SWOT analysis, which used the opinions of laboratory professionals to identify any areas that could be improved to meet quality management systems. Various quality management systems were identified and the number of laboratories that met both international and national quality management requirements was different. The SWOT analysis found the opportunities and strengths factors offered the best chance to improve laboratory quality management in the country. The results are based on observations and brainstorming with medical laboratory professionals who can assist laboratories in accomplishing quality management. The factors derived from the analysis can help improve laboratory quality management in the country. This paper provides viewpoints and evidence-based approaches for the development of best possible practice of services in public health laboratories.

  7. Clinical laboratory technologist professional development in Camagüey

    Directory of Open Access Journals (Sweden)

    Mercedes Caridad García González

    2015-05-01

    Full Text Available The paper describes the results of research aimed at assessing the current conditions related to clinical laboratory technologist professional development. A descriptive cross study covering the period between November 2013 and January 2014 is presented. Several techniques for identifying and hierarchically arranging professional developmental related problems were used to study a sample at the Faculty of Health Technology of the Medical University “Carlos Juan Finlay”. The study involved heads of teaching departments and methodologists of health care technology specialties; moreover a survey and a content test were given graduate clinical laboratory technicians. The authors reached at the conclusion that clinical laboratory technologist professional development is limited and usually underestimate the necessities and interests of these graduates. Likewise, a lack of systematization and integration of the biomedical basic sciences contents and the laboratory diagnosis is noticeable.

  8. Targets development at Sandia National Laboratories

    International Nuclear Information System (INIS)

    Smith, M.L.; Hebron, D.; Derzon, M.; Olson, R.; Alberts, T.

    1997-01-01

    For many years, Sandia National Laboratories under contract to the Department of Energy has produced targets designed to understand complex ion beam and z-pinch plasma physics. This poster focuses on the features of target designs that make them suitable for Z-pinch plasma physics applications. Precision diagnostic targets will prove critical in understanding the plasma physics model needed for future ion beam and z-pinch design. Targets are designed to meet specific physics needs; in this case the authors have fabricated targets to maximize information about the end-on versus side-on x-ray emission and z-pinch hohlraum development. In this poster, they describe the fabrication and characterization techniques. They include discussion of current targets under development as well as target fabrication capabilities. Advanced target designs are fabricated by Sandia National Laboratories in cooperation with General Atomics of San Diego, CA and W.J. Schafer Associates, Inc. of Livermore, CA

  9. Laboratory directed research and development annual report: Fiscal year 1992

    International Nuclear Information System (INIS)

    1993-01-01

    The Department of Energy Order DOE 5000.4A establishes DOE's policy and guidelines regarding Laboratory Directed Research and Development (LDRD) at its multiprogram laboratories. As described in 5000.4A, LDRD is ''research and development of a creative and innovative nature which is selected by the Laboratory Director or his or her designee, for the purpose of maintaining the scientific and technological vitality of the Laboratory and to respond to scientific and technological opportunities in conformance with the guidelines in this order. Consistent with the Mission Statement and Strategic Plan provided in PNL's Institutional Plan, the LDRD investments are focused on developing new and innovative approaches to research related to our ''core competencies.'' Currently, PNL's core competencies have been identified as: integrated environmental research; process science and engineering; energy distribution and utilization. In this report, the individual summaries of Laboratory-level LDRD projects are organized according to these corecompetencies. The largest proportion of Laboratory-level LDRD funds is allocated to the core competency of integrated environmental research. The projects described in this report represent PNL's investment in its future and are vital to maintaining the ability to develop creative solutions for the scientific and technical challenges faced by DOE and the nation. The report provides an overview of PNL's LDRD program and the management process used for the program and project summaries for each LDRD project

  10. Laboratory Directed Research and Development FY-15 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Pillai, Rekha Sukamar [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-03-01

    The Laboratory Directed Research and Development (LDRD) Program at Idaho National Laboratory (INL) reports its status to the U.S. Department of Energy (DOE) by March of each year. The program operates under the authority of DOE Order 413.2B, “Laboratory Directed Research and Development” (April 19, 2006), which establishes DOE’s requirements for the program while providing the laboratory director broad flexibility for program implementation. LDRD funds are obtained through a charge to all INL programs. This report includes summaries of all INL LDRD research activities supported during Fiscal Year (FY) 2015.

  11. 2014 Fermilab Laboratory Directoed Research & Development Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Wester, W. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

    2016-05-26

    After initiation by the Fermilab Laboratory Director, a team from the senior Laboratory leadership and a Laboratory Directed Research and Development (LDRD) Advisory Committee developed an implementation plan for LDRD at Fermilab for the first time. This implementation was captured in the approved Fermilab 2014 LDRD Program Plan and followed directions and guidance from the Department of Energy (DOE) order, DOE O 413.2B, a “Roles, Responsibilities, and Guidelines, …” document, and examples of best practices at other DOE Office of Science Laboratories. At Fermilab, a FY14 midyear Call for Proposals was issued. A LDRD Selection Committee evaluated those proposals that were received and provided a recommendation to the Laboratory Director who approved seven LDRD projects. This Annual Report focuses on the status of those seven projects and provides an overview of the current status of LDRD at Fermilab. The seven FY14 LDRD approved projects had a date of initiation late in FY14 such that this report reflects approximately six months of effort approximately through January 2015. The progress of these seven projects, the subsequent award of six additional new projects beginning in FY15, and preparations for the issuance of the FY16 Call for Proposals indicates that LDRD is now integrated into the overall annual program at Fermilab. All indications are that LDRD is improving the scientific and technical vitality of the Laboratory and providing new, novel, or cutting edge projects carried out at the forefront of science and technology and aligned with the mission and strategic visions of Fermilab and the Department of Energy.

  12. Laboratory directed research and development. FY 1991 program activities: Summary report

    Energy Technology Data Exchange (ETDEWEB)

    1991-11-15

    The purposes of Argonne`s Laboratory Directed Research and Development (LDRD) Program are to encourage the development of novel concepts, enhance the Laboratory`s R&D capabilities, and further the development of its strategic initiatives. Among the aims of the projects supported by the Program are establishment of engineering ``proof-of-principle``; development of an instrumental prototype, method, or system; or discovery in fundamental science. Several of these project are closely associated with major strategic thrusts of the Laboratory as described in Argonne`s Five Year Institutional Plan, although the scientific implications of the achieved results extend well beyond Laboratory plans and objectives. The projects supported by the Program are distributed across the major programmatic areas at Argonne. Areas of emphasis are (1) advanced accelerator and detector technology, (2) x-ray techniques in biological and physical sciences, (3) advanced reactor technology, (4) materials science, computational science, biological sciences and environmental sciences. Individual reports summarizing the purpose, approach, and results of projects are presented.

  13. Laboratory-directed research and development

    International Nuclear Information System (INIS)

    Gerstl, S.A.W.; Caughran, A.B.

    1992-05-01

    This report summarizes progress from the Laboratory-Directed Research and Development (LDRD) program during fiscal year 1991. In addition to a programmatic and financial overview, the report includes progress reports from 230 individual R ampersand D projects in 9 scientific categories: atomic and molecular physics; biosciences; chemistry; engineering and base technologies; geosciences; space sciences, and astrophysics; materials sciences; mathematics and computational sciences; nuclear and particle physics; and plasmas, fluids, and particle beams

  14. The risk of newly developed visual impairment in treated normal-tension glaucoma: 10-year follow-up.

    Science.gov (United States)

    Choi, Yun Jeong; Kim, Martha; Park, Ki Ho; Kim, Dong Myung; Kim, Seok Hwan

    2014-12-01

    To investigate the risk and risk factors for newly developed visual impairment in treated patients with normal-tension glaucoma (NTG) followed up on for 10 years. Patients with NTG, who did not have visual impairment at the initial diagnosis and had undergone intraocular pressure (IOP)-lowering treatment for more than 7 years, were included on the basis of a retrospective chart review. Visual impairment was defined as either low vision (0.05 [20/400] ≤ visual acuity (VA) visual field (VF) visual impairment, Kaplan-Meier survival analysis and generalized linear mixed effects models were utilized. During the 10.8 years mean follow-up period, 20 eyes of 16 patients were diagnosed as visual impairment (12 eyes as low vision, 8 as blindness) among 623 eyes of 411 patients. The cumulative risk of visual impairment in at least one eye was 2.8% at 10 years and 8.7% at 15 years. The risk factors for visual impairment from treated NTG were worse VF mean deviation (MD) at diagnosis and longer follow-up period. The risk of newly developed visual impairment in the treated patients with NTG was relatively low. Worse VF MD at diagnosis and longer follow-up period were associated with development of visual impairment. © 2014 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

  15. Environmental isotope hydrology laboratories in developing countries

    International Nuclear Information System (INIS)

    Gonfiantini, R.; Stichler, W.

    1991-01-01

    This article reports on the role, experience, and problems of environmental isotope hydrology laboratories in developing countries, based upon the IAEA's experience. It specifically offers guidance on important aspects of organization, staffing, and operation

  16. Laboratory directed research and development annual report: Fiscal year 1992

    Energy Technology Data Exchange (ETDEWEB)

    1993-01-01

    The Department of Energy Order DOE 5000.4A establishes DOE`s policy and guidelines regarding Laboratory Directed Research and Development (LDRD) at its multiprogram laboratories. As described in 5000.4A, LDRD is ``research and development of a creative and innovative nature which is selected by the Laboratory Director or his or her designee, for the purpose of maintaining the scientific and technological vitality of the Laboratory and to respond to scientific and technological opportunities in conformance with the guidelines in this order. Consistent with the Mission Statement and Strategic Plan provided in PNL`s Institutional Plan, the LDRD investments are focused on developing new and innovative approaches to research related to our ``core competencies.`` Currently, PNL`s core competencies have been identified as: integrated environmental research; process science and engineering; energy distribution and utilization. In this report, the individual summaries of Laboratory-level LDRD projects are organized according to these corecompetencies. The largest proportion of Laboratory-level LDRD funds is allocated to the core competency of integrated environmental research. The projects described in this report represent PNL`s investment in its future and are vital to maintaining the ability to develop creative solutions for the scientific and technical challenges faced by DOE and the nation. The report provides an overview of PNL`s LDRD program and the management process used for the program and project summaries for each LDRD project.

  17. Laboratory directed research and development annual report: Fiscal year 1992

    Energy Technology Data Exchange (ETDEWEB)

    1993-01-01

    The Department of Energy Order DOE 5000.4A establishes DOE's policy and guidelines regarding Laboratory Directed Research and Development (LDRD) at its multiprogram laboratories. As described in 5000.4A, LDRD is research and development of a creative and innovative nature which is selected by the Laboratory Director or his or her designee, for the purpose of maintaining the scientific and technological vitality of the Laboratory and to respond to scientific and technological opportunities in conformance with the guidelines in this order. Consistent with the Mission Statement and Strategic Plan provided in PNL's Institutional Plan, the LDRD investments are focused on developing new and innovative approaches to research related to our core competencies.'' Currently, PNL's core competencies have been identified as: integrated environmental research; process science and engineering; energy distribution and utilization. In this report, the individual summaries of Laboratory-level LDRD projects are organized according to these corecompetencies. The largest proportion of Laboratory-level LDRD funds is allocated to the core competency of integrated environmental research. The projects described in this report represent PNL's investment in its future and are vital to maintaining the ability to develop creative solutions for the scientific and technical challenges faced by DOE and the nation. The report provides an overview of PNL's LDRD program and the management process used for the program and project summaries for each LDRD project.

  18. Laboratory Directed Research and Development Program Assessment for FY 2008

    Energy Technology Data Exchange (ETDEWEB)

    Looney, J P; Fox, K J

    2008-03-31

    Brookhaven National Laboratory (BNL) is a multidisciplinary Laboratory that carries out basic and applied research in the physical, biomedical, and environmental sciences, and in selected energy technologies. It is managed by Brookhaven Science Associates, LLC, (BSA) under contract with the U. S. Department of Energy (DOE). BNL's Fiscal Year 2008 spending was $531.6 million. There are approximately 2,800 employees, and another 4,300 guest scientists and students who come each year to use the Laboratory's facilities and work with the staff. The BNL Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) annually in March, as required by DOE Order 413.2B, 'Laboratory Directed Research and Development,' April 19, 2006, and the Roles, Responsibilities, and Guidelines for Laboratory Directed Research and Development at the Department of Energy/National Nuclear Security Administration Laboratories dated June 13, 2006. The goals and objectives of BNL's LDRD Program can be inferred from the Program's stated purposes. These are to (1) encourage and support the development of new ideas and technology, (2) promote the early exploration and exploitation of creative and innovative concepts, and (3) develop new 'fundable' R&D projects and programs. The emphasis is clearly articulated by BNL to be on supporting exploratory research 'which could lead to new programs, projects, and directions' for the Laboratory. To be a premier scientific Laboratory, BNL must continuously foster groundbreaking scientific research and renew its research agenda. The competition for LDRD funds stimulates Laboratory scientists to think in new and creative ways, which becomes a major factor in achieving and maintaining research excellence and a means to address National needs within the overall mission of the DOE and BNL. By fostering high-risk, exploratory research, the LDRD program helps

  19. Laboratory Directed Research and Development Program FY 2007 Annual Report

    International Nuclear Information System (INIS)

    Sjoreen, Terrence P.

    2008-01-01

    The Oak Ridge National LaboratoryLaboratory Directed Research and Development (LDRD) program reports its status to the U.S. Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, 'Laboratory Directed Research and Development' (April 19, 2006), which establishes DOE's requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries for all ORNL LDRD research activities supported during FY 2007. The associated FY 2007 ORNL LDRD Self-Assessment (ORNL/PPA-2008/2) provides financial data and an internal evaluation of the program's management process. ORNL is a DOE multiprogram science, technology, and energy laboratory with distinctive capabilities in materials science and engineering, neutron science and technology, energy production and end-use technologies, biological and environmental science, and scientific computing. With these capabilities ORNL conducts basic and applied research and development (R and D) to support DOE's overarching mission to advance the national, economic, and energy security of the United States and promote scientific and technological innovation in support of that mission. As a national resource, the Laboratory also applies its capabilities and skills to specific needs of other federal agencies and customers through the DOE Work for Others (WFO) program. Information about the Laboratory and its programs is available on the Internet at http://www.ornl.gov/. LDRD is a relatively small but vital DOE program that allows ORNL, as well as other DOE laboratories, to select a limited number of R and D projects for the purpose of: (1) maintaining the scientific and technical vitality of the Laboratory; (2) enhancing the Laboratory's ability to address future DOE missions; (3) fostering creativity and stimulating exploration of forefront science

  20. Laboratory Directed Research and Development Program FY 2007 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Sjoreen, Terrence P [ORNL

    2008-04-01

    The Oak Ridge National Laboratory (ORNL) Laboratory Directed Research and Development (LDRD) program reports its status to the U.S. Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, 'Laboratory Directed Research and Development' (April 19, 2006), which establishes DOE's requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries for all ORNL LDRD research activities supported during FY 2007. The associated FY 2007 ORNL LDRD Self-Assessment (ORNL/PPA-2008/2) provides financial data and an internal evaluation of the program's management process. ORNL is a DOE multiprogram science, technology, and energy laboratory with distinctive capabilities in materials science and engineering, neutron science and technology, energy production and end-use technologies, biological and environmental science, and scientific computing. With these capabilities ORNL conducts basic and applied research and development (R&D) to support DOE's overarching mission to advance the national, economic, and energy security of the United States and promote scientific and technological innovation in support of that mission. As a national resource, the Laboratory also applies its capabilities and skills to specific needs of other federal agencies and customers through the DOE Work for Others (WFO) program. Information about the Laboratory and its programs is available on the Internet at http://www.ornl.gov/. LDRD is a relatively small but vital DOE program that allows ORNL, as well as other DOE laboratories, to select a limited number of R&D projects for the purpose of: (1) maintaining the scientific and technical vitality of the Laboratory; (2) enhancing the Laboratory's ability to address future DOE missions; (3) fostering creativity and stimulating

  1. Value of a newly sequenced bacterial genome

    DEFF Research Database (Denmark)

    Barbosa, Eudes; Aburjaile, Flavia F; Ramos, Rommel Tj

    2014-01-01

    and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the "scientific value" of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses...... heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting...

  2. Laboratory Directed Research and Development Program Activities for FY 2007.

    Energy Technology Data Exchange (ETDEWEB)

    Newman,L.

    2007-12-31

    Brookhaven National Laboratory (BNL) is a multidisciplinary laboratory that carries out basic and applied research in the physical, biomedical, and environmental sciences, and in selected energy technologies. It is managed by Brookhaven Science Associates, LLC, (BSA) under contract with the U. S. Department of Energy (DOE). BNL's Fiscal year 2007 budget was $515 million. There are about 2,600 employees, and another 4,500 guest scientists and students who come each year to use the Laboratory's facilities and work with the staff. The BNL Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) annually in March, as required by DOE Order 413.2B, 'Laboratory Directed Research and Development', April 19, 2006, and the Roles, Responsibilities, and Guidelines for Laboratory Directed Research and Development at the Department of Energy/National Nuclear Security Administration Laboratories dated June 13, 2006. In accordance this is our Annual Report in which we describe the Purpose, Approach, Technical Progress and Results, and Specific Accomplishments of all LDRD projects that received funding during Fiscal Year 2007. The goals and objectives of BNL's LDRD Program can be inferred from the Program's stated purposes. These are to (1) encourage and support the development of new ideas and technology, (2) promote the early exploration and exploitation of creative and innovative concepts, and (3) develop new 'fundable' R&D projects and programs. The emphasis is clearly articulated by BNL to be on supporting exploratory research 'which could lead to new programs, projects, and directions' for the Laboratory. We explicitly indicate that research conducted under the LDRD Program should be highly innovative, and an element of high risk as to success is acceptable. In the solicitation for new proposals for Fiscal Year 2007 we especially requested innovative new projects in

  3. Laboratory-Directed Research and Development 2016 Summary Annual Report

    International Nuclear Information System (INIS)

    Pillai, Rekha Sukamar; Jacobson, Julie Ann

    2017-01-01

    The Laboratory-Directed Research and Development (LDRD) Program at Idaho National Laboratory (INL) reports its status to the U.S. Department of Energy (DOE) by March of each year. The program operates under the authority of DOE Order 413.2C, 'Laboratory Directed Research and Development' (April 19, 2006), which establishes DOE's requirements for the program while providing the laboratory director broad flexibility for program implementation. LDRD funds are obtained through a charge to all INL programs. This report includes summaries of all INL LDRD research activities supported during Fiscal Year (FY) 2016. INL is the lead laboratory for the DOE Office of Nuclear Energy (DOE-NE). The INL mission is to discover, demonstrate, and secure innovative nuclear energy solutions, other clean energy options, and critical infrastructure with a vision to change the world's energy future and secure our critical infrastructure. Operating since 1949, INL is the nation's leading research, development, and demonstration center for nuclear energy, including nuclear nonproliferation and physical and cyber-based protection of energy systems and critical infrastructure, as well as integrated energy systems research, development, demonstration, and deployment. INL has been managed and operated by Battelle Energy Alliance, LLC (a wholly owned company of Battelle) for DOE since 2005. Battelle Energy Alliance, LLC, is a partnership between Battelle, BWX Technologies, Inc., AECOM, the Electric Power Research Institute, the National University Consortium (Massachusetts Institute of Technology, Ohio State University, North Carolina State University, University of New Mexico, and Oregon State University), and the Idaho university collaborators (i.e., University of Idaho, Idaho State University, and Boise State University). Since its creation, INL's research and development (R&D) portfolio has broadened with targeted programs supporting national missions to advance nuclear energy, enable clean

  4. Developing a strategy for a regulated electronic bioanalytical laboratory.

    Science.gov (United States)

    McDowall, R D

    2014-01-01

    This perspective article considers the strategy, design and implementation of an electronic bioanalytical laboratory working to GLP and/or GCP regulations. There are a range of available automated systems and laboratory informatics that could be implemented and integrated to make an electronic laboratory. However, which are the appropriate ones to select and what is realistic and cost-effective for an individual laboratory? The answer is to develop an overall automation strategy that is updated periodically after each system or application has been implemented to assess if the strategy is still valid or needs to be changed. As many laboratory informatics applications have functional overlap or convergence, for example, Laboratory Information Management System, Electronic Laboratory Notebook, and Instrument and Chromatography Data Systems, the decision of which application performs a specific task needs to be carefully considered in the overall strategy. Ensuring data integrity and regulatory compliance, especially in light of a number of recent falsification cases, is a mandatory consideration for the overall strategy for an electronic bioanalytical laboratory submitting data to regulatory authorities.

  5. Underground trials on a newly developed EDW 150-2 L unit

    Energy Technology Data Exchange (ETDEWEB)

    Wille, G.; Klimek, K.H.

    1982-01-01

    Coal-getting from medium thick coalbeds (> 1.7 m) requires high-performance shearer-loaders. Machine length and adjustability have to be such as to permit smooth cutting through geological faults. Furthermore they should be suitable to cut out niches for the AFC drives so that gateroads can be driven along with the face line. The newly developed EDW 150-2 L shearer-loader meets these expectations after various mechanical and electrical improvements. The unit proved its usefulness from the beginning and in the most difficult geological conditions where other shearer-loaders normally available for the range of coalbed thickness would mostly have failed. The multiple requirements and disturbances have led to a number of separate improvements and disturbances have led to a number of separate improvements which together contribute to a basic improvement of the machine concept as far as applications, operational flexibility and safety are concerned.

  6. Laboratory Directed Research and Development Program Activities for FY 2008.

    Energy Technology Data Exchange (ETDEWEB)

    Looney,J.P.; Fox, K.

    2009-04-01

    Brookhaven National Laboratory (BNL) is a multidisciplinary laboratory that maintains a primary mission focus the physical sciences, energy sciences, and life sciences, with additional expertise in environmental sciences, energy technologies, and national security. It is managed by Brookhaven Science Associates, LLC, (BSA) under contract with the U. S. Department of Energy (DOE). BNL's Fiscal year 2008 budget was $531.6 million. There are about 2,800 employees, and another 4,300 guest scientists and students who come each year to use the Laboratory's facilities and work with the staff. The BNL Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) annually in March, as required by DOE Order 413.2B, 'Laboratory Directed Research and Development,' April 19, 2006, and the Roles, Responsibilities, and Guidelines for Laboratory Directed Research and Developlnent at the Department of Energy/National Nuclear Security Administration Laboratories dated June 13, 2006. Accordingly, this is our Annual Report in which we describe the Purpose, Approach, Technical Progress and Results, and Specific Accomplishments of all LDRD projects that received funding during Fiscal Year 2008. BNL expended $12 million during Fiscal Year 2008 in support of 69 projects. The program has two categories, the annual Open Call LDRDs and Strategic LDRDs, which combine to meet the overall objectives of the LDRD Program. Proposals are solicited annually for review and approval concurrent with the next fiscal year, October 1. For the open call for proposals, an LDRD Selection Committee, comprised of the Associate Laboratory Directors (ALDs) for the Scientific Directorates, an equal number of scientists recommended by the Brookhaven Council, plus the Assistant Laboratory Director for Policy and Strategic Planning, review the proposals submitted in response to the solicitation. The Open Can LDRD category emphasizes innovative research concepts

  7. Timing of entry to care by newly diagnosed HIV cases before and after the 2010 New York State HIV testing law.

    Science.gov (United States)

    Gordon, Daniel E; Bian, Fuqin; Anderson, Bridget J; Smith, Lou C

    2015-01-01

    Prompt entry to care after HIV diagnosis benefits the infected individual and reduces the likelihood of further transmission of the virus. The New York State HIV Testing Law of 2010 requires diagnosing providers to refer persons newly diagnosed with HIV to follow-up medical care. This study used routinely collected HIV-related laboratory data from the New York State HIV surveillance system to assess whether the fraction of newly diagnosed cases entering care within 90 days of diagnosis increased after the implementation of the law. Laboratory data on 23,302 newly diagnosed cases showed that entry to care within 90 days rose steadily from 72.0% in 2007 to 85.4% in 2012. The rise was observed across all race/ethnic groups, ages, transmission risk groups, sexes, and regions of residence. Logistic regression analyses of entry to care pre-law and post-law, controlling for demographic characteristics, transmission risk, and geographic area, indicate that percentage of newly diagnosed cases entering care within 90 days grew more rapidly in the post-law period. This is consistent with a positive effect of the law on entry to care.

  8. A Newly Improved Modified Method Development and Validation of Bromofenac Sodium Sesquihydrate in Bulk Drug Manufacturing

    OpenAIRE

    Sunil Kumar Yelamanchi V; Useni Reddy Mallu; I. V Kasi Viswanath; D. Balasubramanyam; G. Narshima Murthy

    2016-01-01

    The main objective of this study was to develop a simple, efficient, specific, precise and accurate newly improved modified Reverse Phase High Performance Liquid Chromatographic Purity (or) Related substance method for bromofenac sodium sesquihydrate active pharmaceuticals ingredient dosage form. Validation of analytical method is the confirmation by examination and the provision of objective evidence that the particular requirements for a specific intended use are fulfilled as per ICH, USP...

  9. Laboratory Directed Research and Development FY 1992

    Energy Technology Data Exchange (ETDEWEB)

    Struble, G.L.; Middleton, C.; Anderson, S.E.; Baldwin, G.; Cherniak, J.C.; Corey, C.W.; Kirvel, R.D.; McElroy, L.A. [eds.

    1992-12-31

    The Laboratory Directed Research and Development (LDRD) Program at Lawrence Livermore National Laboratory (LLNL) funds projects that nurture and enrich the core competencies of the Laboratory. The scientific and technical output from the FY 1992 RD Program has been significant. Highlights include (1) Creating the first laser guide star to be coupled with adaptive optics, thus permitting ground-based telescopes to obtain the same resolution as smaller space-based instruments but with more light-gathering power. (2) Significantly improving the limit on the mass of the electron antineutrino so that neutrinos now become a useful tool in diagnosing supernovas and we disproved the existence of a 17-keV neutrino. (3) Developing a new class of organic aerogels that have robust mechanical properties and that have significantly lower thermal conductivity than inorganic aerogels. (4) Developing a new heavy-ion accelerator concept, which may enable us to design heavy-ion experimental systems and use a heavy-ion driver for inertial fusion. (5) Designing and demonstrating a high-power, diode-pumped, solid-state laser concept that will allow us to pursue a variety of research projects, including laser material processing. (6) Demonstrating that high-performance semiconductor arrays can be fabricated more efficiently, which will make this technology available to a broad range of applications such as inertial confinement fusion for civilian power. (7) Developing a new type of fiber channel switch and new fiber channel standards for use in local- and wide-area networks, which will allow scientists and engineers to transfer data at gigabit rates. (8) Developing the nation`s only numerical model for high-technology air filtration systems. Filter designs that use this model will provide safer and cleaner environments in work areas where contamination with particulate hazardous materials is possible.

  10. Laboratory Directed Research and Development FY 1992

    International Nuclear Information System (INIS)

    Struble, G.L.; Middleton, C.; Anderson, S.E.; Baldwin, G.; Cherniak, J.C.; Corey, C.W.; Kirvel, R.D.; McElroy, L.A.

    1992-01-01

    The Laboratory Directed Research and Development (LDRD) Program at Lawrence Livermore National Laboratory (LLNL) funds projects that nurture and enrich the core competencies of the Laboratory. The scientific and technical output from the FY 1992 RD Program has been significant. Highlights include (1) Creating the first laser guide star to be coupled with adaptive optics, thus permitting ground-based telescopes to obtain the same resolution as smaller space-based instruments but with more light-gathering power. (2) Significantly improving the limit on the mass of the electron antineutrino so that neutrinos now become a useful tool in diagnosing supernovas and we disproved the existence of a 17-keV neutrino. (3) Developing a new class of organic aerogels that have robust mechanical properties and that have significantly lower thermal conductivity than inorganic aerogels. (4) Developing a new heavy-ion accelerator concept, which may enable us to design heavy-ion experimental systems and use a heavy-ion driver for inertial fusion. (5) Designing and demonstrating a high-power, diode-pumped, solid-state laser concept that will allow us to pursue a variety of research projects, including laser material processing. (6) Demonstrating that high-performance semiconductor arrays can be fabricated more efficiently, which will make this technology available to a broad range of applications such as inertial confinement fusion for civilian power. (7) Developing a new type of fiber channel switch and new fiber channel standards for use in local- and wide-area networks, which will allow scientists and engineers to transfer data at gigabit rates. (8) Developing the nation's only numerical model for high-technology air filtration systems. Filter designs that use this model will provide safer and cleaner environments in work areas where contamination with particulate hazardous materials is possible

  11. Laboratory Directed Research and Development Program FY98

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, T. [ed.; Chartock, M.

    1999-02-05

    The Ernest Orlando Lawrence Berkeley National Laboratory (LBNL or Berkeley Lab) Laboratory Directed Research and Development Program FY 1998 report is compiled from annual reports submitted by principal investigators following the close of the fiscal year. This report describes the supported projects and summarizes their accomplishments. It constitutes a part of the Laboratory Directed Research and Development (LDRD) program planning and documentation process that includes an annual planning cycle, projection selection, implementation, and review. The LBNL LDRD program is a critical tool for directing the Laboratory's forefront scientific research capabilities toward vital, excellent, and emerging scientific challenges. The program provides the resources for LBNL scientists to make rapid and significant contributions to critical national science and technology problems. The LDRD program also advances LBNL's core competencies, foundations, and scientific capability, and permits exploration of exciting new opportunities. All projects are work in forefront areas of science and technology. Areas eligible for support include the following: Advanced study of hypotheses, concepts, or innovative approaches to scientific or technical problems; Experiments and analyses directed toward ''proof of principle'' or early determination of the utility of new scientific ideas, technical concepts, or devices; and Conception and preliminary technical analyses of experimental facilities or devices.

  12. Development of a one-step RT-PCR assay for detection of pancoronaviruses (α-, β-, γ-, and δ-coronaviruses) using newly designed degenerate primers for porcine and avian `fecal samples.

    Science.gov (United States)

    Hu, Hui; Jung, Kwonil; Wang, Qiuhong; Saif, Linda J; Vlasova, Anastasia N

    2018-06-01

    Coronaviruses (CoVs) are critical human and animal pathogens because of their potential to cause severe epidemics of respiratory or enteric diseases. In pigs, the newly emerged porcine deltacoronavirus (PDCoV) and re-emerged porcine epidemic diarrhea virus (PEDV) reported in the US and Asia, as well as the discovery of novel CoVs in wild bats or birds, has necessitated development of improved detection and control measures for these CoVs. Because the previous pancoronavirus (panCoV) RT-PCR established in our laboratory in 2007-2011 did not detect deltacoronaviruses (δ-CoVs) in swine fecal and serum samples, our goal was to develop a new panCoV RT-PCR assay to detect known human and animal CoVs, including δ-CoVs. In this study, we designed a new primer set to amplify a 668 bp-region within the RNA-dependent RNA polymerase (RdRP) gene that encodes the most conserved protein domain of α-, β-, γ-, and δ-CoVs. We established a one-step panCoV RT-PCR assay and standardized the assay conditions. The newly established panCoV RT-PCR assay was demonstrated to have a high sensitivity and specificity. Using a panel of 60 swine biological samples (feces, intestinal contents, and sera) characterized by PEDV, PDCoV and transmissible gastroenteritis virus-specific RT-PCR assays, we demonstrated that sensitivity and specificity of the newly established panCoV RT-PCR assay were 100%. 400 avian fecal (RNA) samples were further tested simultaneously for CoV by the new panCoV RT-PCR and a one-step RT-PCR assay with the δ-CoV nucleocapsid-specific universal primers. Four of 400 avian samples were positive for CoV, three of which were positive for δ-CoV by the conventional RT-PCR. PanCoV RT-PCR fragments for 3 of the 4 CoVs were sequenced. Phylogenetic analysis revealed the presence of one γ-CoV and two δ-CoV in the sequenced samples. The newly designed panCoV RT-PCR assay should be useful for the detection of currently known CoVs in animal biological samples. Copyright © 2018

  13. Laboratory directed research and development FY98 annual report; TOPICAL

    International Nuclear Information System (INIS)

    Al-Ayat, R; Holzrichter, J

    1999-01-01

    In 1984, Congress and the Department of Energy (DOE) established the Laboratory Directed Research and Development (LDRD) Program to enable the director of a national laboratory to foster and expedite innovative research and development (R and D) in mission areas. The Lawrence Livermore National Laboratory (LLNL) continually examines these mission areas through strategic planning and shapes the LDRD Program to meet its long-term vision. The goal of the LDRD Program is to spur development of new scientific and technical capabilities that enable LLNL to respond to the challenges within its evolving mission areas. In addition, the LDRD Program provides LLNL with the flexibility to nurture and enrich essential scientific and technical competencies and enables the Laboratory to attract the most qualified scientists and engineers. The FY98 LDRD portfolio described in this annual report has been carefully structured to continue the tradition of vigorously supporting DOE and LLNL strategic vision and evolving mission areas. The projects selected for LDRD funding undergo stringent review and selection processes, which emphasize strategic relevance and require technical peer reviews of proposals by external and internal experts. These FY98 projects emphasize the Laboratory's national security needs: stewardship of the U.S. nuclear weapons stockpile, responsibility for the counter- and nonproliferation of weapons of mass destruction, development of high-performance computing, and support of DOE environmental research and waste management programs

  14. Laboratory Directed Research and Development Program FY 2005 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Sjoreen, Terrence P [ORNL

    2006-04-01

    The Oak Ridge National Laboratory (ORNL) Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2A, 'Laboratory Directed Research and Development' (January 8, 2001), which establishes DOE's requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report describes all ORNL LDRD research activities supported during FY 2005 and includes final reports for completed projects and shorter progress reports for projects that were active, but not completed, during this period. The FY 2005 ORNL LDRD Self-Assessment (ORNL/PPA-2006/2) provides financial data about the FY 2005 projects and an internal evaluation of the program's management process. ORNL is a DOE multiprogram science, technology, and energy laboratory with distinctive capabilities in materials science and engineering, neutron science and technology, energy production and end-use technologies, biological and environmental science, and scientific computing. With these capabilities ORNL conducts basic and applied research and development (R&D) to support DOE's overarching national security mission, which encompasses science, energy resources, environmental quality, and national nuclear security. As a national resource, the Laboratory also applies its capabilities and skills to the specific needs of other federal agencies and customers through the DOE Work For Others (WFO) program. Information about the Laboratory and its programs is available on the Internet at . LDRD is a relatively small but vital DOE program that allows ORNL, as well as other multiprogram DOE laboratories, to select a limited number of R&D projects for the purpose of: (1) maintaining the scientific and technical vitality of the

  15. Laboratory Directed Research and Development Program FY 2004 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Sjoreen, Terrence P [ORNL

    2005-04-01

    The Oak Ridge National Laboratory (ORNL) Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2A, 'Laboratory Directed Research and Development' (January 8, 2001), which establishes DOE's requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report describes all ORNL LDRD research activities supported during FY 2004 and includes final reports for completed projects and shorter progress reports for projects that were active, but not completed, during this period. The FY 2004 ORNL LDRD Self-Assessment (ORNL/PPA-2005/2) provides financial data about the FY 2004 projects and an internal evaluation of the program's management process. ORNL is a DOE multiprogram science, technology, and energy laboratory with distinctive capabilities in materials science and engineering, neutron science and technology, energy production and end-use technologies, biological and environmental science, and scientific computing. With these capabilities ORNL conducts basic and applied research and development (R&D) to support DOE's overarching national security mission, which encompasses science, energy resources, environmental quality, and national nuclear security. As a national resource, the Laboratory also applies its capabilities and skills to the specific needs of other federal agencies and customers through the DOE Work For Others (WFO) program. Information about the Laboratory and its programs is available on the Internet at . LDRD is a relatively small but vital DOE program that allows ORNL, as well as other multiprogram DOE laboratories, to select a limited number of R&D projects for the purpose of: (1) maintaining the scientific and technical vitality of the

  16. Laboratory directed research development annual report. Fiscal year 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-05-01

    This document comprises Pacific Northwest National Laboratory`s report for Fiscal Year 1996 on research and development programs. The document contains 161 project summaries in 16 areas of research and development. The 16 areas of research and development reported on are: atmospheric sciences, biotechnology, chemical instrumentation and analysis, computer and information science, ecological science, electronics and sensors, health protection and dosimetry, hydrological and geologic sciences, marine sciences, materials science and engineering, molecular science, process science and engineering, risk and safety analysis, socio-technical systems analysis, statistics and applied mathematics, and thermal and energy systems. In addition, this report provides an overview of the research and development program, program management, program funding, and Fiscal Year 1997 projects.

  17. Laboratory Directed Research and Development annual report, Fiscal year 1993

    International Nuclear Information System (INIS)

    1994-01-01

    The Department of Energy Order DOE 5000.4A establishes DOE's policy and guidelines regarding Laboratory Directed Research and Development (LDRD) at its multiprogram laboratories. As described in 5000.4A, LDRD is ''research and development of a creative and innovative nature which is selected by the Laboratory Director or his or her designee, for the purpose of maintaining the scientific and technological vitality of the Laboratory and to respond to scientific and technological opportunities in conformance with the guidelines in this Order. LDRD includes activities previously defined as ER ampersand D, as well as other discretionary research and development activities not provided for in a DOE program.'' Consistent with the Mission Statement and Strategic Plan provided in PNL's Institutional Plan, the LDRD investments are focused on developing new and innovative approaches in research related to our ''core competencies.'' Currently, PNL's core competencies have been identified as integrated environmental research; process technology; energy systems research. In this report, the individual summaries of Laboratory-level LDRD projects are organized according to these core competencies. The largest proportion of Laboratory-level LDRD funds is allocated to the core competency of integrated environmental research. A significant proportion of PNL's LDRD funds are also allocated to projects within the various research centers that are proposed by individual researchers or small research teams. The projects are described in Section 2.0. The projects described in this report represent PNL's investment in its future and are vital to maintaining the ability to develop creative solutions for the scientific and technical challenges faced by DOE and the nation. In accordance with DOE guidelines, the report provides an overview of PNL's LDRD program and the management process used for the program and project summaries for each LDRD project

  18. Laboratory Directed Research and Development annual report, Fiscal year 1993

    Energy Technology Data Exchange (ETDEWEB)

    1994-01-01

    The Department of Energy Order DOE 5000.4A establishes DOE`s policy and guidelines regarding Laboratory Directed Research and Development (LDRD) at its multiprogram laboratories. As described in 5000.4A, LDRD is ``research and development of a creative and innovative nature which is selected by the Laboratory Director or his or her designee, for the purpose of maintaining the scientific and technological vitality of the Laboratory and to respond to scientific and technological opportunities in conformance with the guidelines in this Order. LDRD includes activities previously defined as ER&D, as well as other discretionary research and development activities not provided for in a DOE program.`` Consistent with the Mission Statement and Strategic Plan provided in PNL`s Institutional Plan, the LDRD investments are focused on developing new and innovative approaches in research related to our ``core competencies.`` Currently, PNL`s core competencies have been identified as integrated environmental research; process technology; energy systems research. In this report, the individual summaries of Laboratory-level LDRD projects are organized according to these core competencies. The largest proportion of Laboratory-level LDRD funds is allocated to the core competency of integrated environmental research. A significant proportion of PNL`s LDRD funds are also allocated to projects within the various research centers that are proposed by individual researchers or small research teams. The projects are described in Section 2.0. The projects described in this report represent PNL`s investment in its future and are vital to maintaining the ability to develop creative solutions for the scientific and technical challenges faced by DOE and the nation. In accordance with DOE guidelines, the report provides an overview of PNL`s LDRD program and the management process used for the program and project summaries for each LDRD project.

  19. Raising environmental awareness through applied biochemistry laboratory experiments.

    Science.gov (United States)

    Salman Ashraf, S

    2013-01-01

    Our environment is under constant pressure and threat from various sources of pollution. Science students, in particular chemistry students, must not only be made aware of these issues, but also be taught that chemistry (and science) can provide solutions to such real-life issues. To this end, a newly developed biochemistry laboratory experiment is described that guides students to learn about the applicability of peroxidase enzymes to degrade organic dyes (as model pollutants) in simulated waste water. In addition to showing how enzymes can potentially be used for waste water remediation, various factors than can affect enzyme-based reactions such as pH, temperature, concentration of substrates/enzymes, and denaturants can also be tested. This "applied biotechnology" experiment was successfully implemented in an undergraduate biochemistry laboratory course to enhance students' learning of environmental issues as well important biochemistry concepts. Student survey confirmed that this laboratory experiment was successful in achieving the objectives of raising environmental awareness in students and illustrating the usefulness of chemistry in solving real-life problems. This experiment can be easily adopted in an introductory biochemistry laboratory course and taught as an inquiry-guided exercise. © 2013 by The International Union of Biochemistry and Molecular Biology.

  20. Electric air filtration: theory, laboratory studies, hardware development, and field evaluations

    International Nuclear Information System (INIS)

    Bergman, W.; Biermann, A.; Kuhl, W.

    1983-09-01

    We summarize the results of a seven-year research project for the US Department of Energy (DOE) to develop electric air filters that extend the service life of high-efficiency particulate air (HEPA) filters used in the nuclear industry. This project was unique to Lawrence Livermore National Laboratory (LLNL), and it entailed comprehensive theory, laboratory studies, and hardware development. We present our work in three major areas: (1) theory of and instrumentation for filter test methods, (2) theoretical and laboratory studies of electric air filters, and (3) development and evaluation of eight experimental electric air filters

  1. A Newly Developed Nested PCR Assay for the Detection of Helicobacter pylori in the Oral Cavity.

    Science.gov (United States)

    Ismail, Hawazen; Morgan, Claire; Griffiths, Paul; Williams, John; Jenkins, Gareth

    2016-01-01

    To develop a new nested polymerase chain reaction (PCR) assay for identifying Helicobacter pylori DNA from dental plaque. H. pylori is one of the most common chronic bacterial pathogens in humans. The accurate detection of this organism is essential for proper patient management and for the eradication of the bacteria following treatment. Forty-nine patients (24 males and 25 females; mean age: 51; range, 19 to 94 y) were investigated for the presence of H. pylori in dental plaque by single-step PCR and nested PCR and in the stomach by single-step PCR, nested PCR, and histologic examination. The newly developed nested PCR assay identified H. pylori DNA in gastric biopsies of 18 patients who were histologically classified as H. pylori-positive and 2 additional biopsies of patients who were H. pylori-negative by histologic examination (20/49; 40.8%). Dental plaque samples collected before and after endoscopy from the 49 patients revealed that single-step PCR did not detect H. pylori but nested PCR was able to detect H. pylori DNA in 40.8% (20/49) patients. Nested PCR gave a higher detection rate (40.8%, 20/49) than that of histology (36.7%, 18/49) and single-step PCR. When nested PCR results were compared with histology results there was no significant difference between the 2 methods. Our newly developed nested PCR assay is at least as sensitive as histology and may be useful for H. pylori detection in patients unfit for endoscopic examination.

  2. Characteristics of bread prepared from wheat flours blended with various kinds of newly developed rice flours.

    Science.gov (United States)

    Nakamura, S; Suzuki, K; Ohtsubo, K

    2009-04-01

    Characteristics of the bread prepared from wheat flour blended with the flour of various kinds of newly developed rice cultivars were investigated. Qualities of the bread made from wheat flour blended with rice flour have been reported to be inferior to those from 100% wheat flour bread. To improve its qualities, we searched for the new-characteristic rice flours among the various kinds of newly developed rice cultivars to blend with the wheat flour for the bread preparation. The most suitable new characteristic rices are combination of purple waxy rice, high-amylose rice, and sugary rice. Specific volume of the bread from the combination of wheat and these 3 kinds of rice flours showed higher specific volume (3.93) compared with the traditional wheat/rice bread (3.58). We adopted the novel method, continuous progressive compression test, to measure the physical properties of the dough and the bread in addition to the sensory evaluation. As a result of the selection of the most suitable rice cultivars and blending ratio with the wheat flour, we could develop the novel wheat/rice bread, of which loaf volume, physical properties, and tastes are acceptable and resistant to firming on even 4 d after the bread preparation. To increase the ratio of rice to wheat, we tried to add a part of rice as cooked rice grains. The specific volume and qualities of the bread were maintained well although the rice content of total flour increased from 30% to 40%.

  3. [Strategy Development for International Cooperation in the Clinical Laboratory Field].

    Science.gov (United States)

    Kudo, Yoshiko; Osawa, Susumu

    2015-10-01

    The strategy of international cooperation in the clinical laboratory field was analyzed to improve the quality of intervention by reviewing documents from international organizations and the Japanese government. Based on the world development agenda, the target of action for health has shifted from communicable diseases to non-communicable diseases (NCD). This emphasizes the importance of comprehensive clinical laboratories instead of disease-specific examinations in developing countries. To achieve this goal, the World Health Organization (WHO) has disseminated to the African and Asian regions the Laboratory Quality Management System (LQMS), which is based on the same principles of the International Organization of Standardization (ISO) 15189. To execute this strategy, international experts must have competence in project management, analyze information regarding the target country, and develop a strategy for management of the LQMS with an understanding of the technical aspects of laboratory work. However, there is no appropriate pre- and post-educational system of international health for Japanese international workers. Universities and academic organizations should cooperate with the government to establish a system of education for international workers. Objectives of this education system must include: (1) training for the organization and understanding of global health issues, (2) education of the principles regarding comprehensive management of clinical laboratories, and (3) understanding the LQMS which was employed based on WHO's initiative. Achievement of these objectives will help improve the quality of international cooperation in the clinical laboratory field.

  4. Development of a free software for laboratory of metrology

    International Nuclear Information System (INIS)

    Silveira, Renata R. da; Benevides, Clayton A.

    2014-01-01

    The Centro Regional de Ciencias Nucleares do Nordeste (CRCN-NE) has a Metrology Laboratory to realize radioactive assays and calibrations in X and gamma radiation. This job, realized before in a manual way, had only paper recording and a hard-working data recovery. The objective of this job was to develop an application with free software to manage the laboratory activities, as service recording, rastreability control and environmental conditions monitoring, beyond automate the certificates and reports. As result, we have obtained the optimization of the routine and the management of the laboratory. (author)

  5. Establishment probability in newly founded populations

    Directory of Open Access Journals (Sweden)

    Gusset Markus

    2012-06-01

    Full Text Available Abstract Background Establishment success in newly founded populations relies on reaching the established phase, which is defined by characteristic fluctuations of the population’s state variables. Stochastic population models can be used to quantify the establishment probability of newly founded populations; however, so far no simple but robust method for doing so existed. To determine a critical initial number of individuals that need to be released to reach the established phase, we used a novel application of the “Wissel plot”, where –ln(1 – P0(t is plotted against time t. This plot is based on the equation P0t=1–c1e–ω1t, which relates the probability of extinction by time t, P0(t, to two constants: c1 describes the probability of a newly founded population to reach the established phase, whereas ω1 describes the population’s probability of extinction per short time interval once established. Results For illustration, we applied the method to a previously developed stochastic population model of the endangered African wild dog (Lycaon pictus. A newly founded population reaches the established phase if the intercept of the (extrapolated linear parts of the “Wissel plot” with the y-axis, which is –ln(c1, is negative. For wild dogs in our model, this is the case if a critical initial number of four packs, consisting of eight individuals each, are released. Conclusions The method we present to quantify the establishment probability of newly founded populations is generic and inferences thus are transferable to other systems across the field of conservation biology. In contrast to other methods, our approach disaggregates the components of a population’s viability by distinguishing establishment from persistence.

  6. Laboratory directed research and development program FY 1999

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Todd; Levy, Karin

    2000-03-08

    The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab or LBNL) is a multi-program national research facility operated by the University of California for the Department of Energy (DOE). As an integral element of DOE's National Laboratory System, Berkeley Lab supports DOE's missions in fundamental science, energy resources, and environmental quality. Berkeley Lab programs advance four distinct goals for DOE and the nation: (1) To perform leading multidisciplinary research in the computing sciences, physical sciences, energy sciences, biosciences, and general sciences in a manner that ensures employee and public safety and protection of the environment. (2) To develop and operate unique national experimental facilities for qualified investigators. (3) To educate and train future generations of scientists and engineers to promote national science and education goals. (4) To transfer knowledge and technological innovations and to foster productive relationships among Berkeley Lab's research programs, universities, and industry in order to promote national economic competitiveness. This is the annual report on Laboratory Directed Research and Development (LDRD) program for FY99.

  7. Laboratory Directed Research and Development Program FY 2001

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Todd; Levy, Karin

    2002-03-15

    The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab or LBNL) is a multi-program national research facility operated by the University of California for the Department of Energy (DOE). As an integral element of DOE's National Laboratory System, Berkeley Lab supports DOE's missions in fundamental science, energy resources, and environmental quality. Berkeley Lab programs advance four distinct goals for DOE and the nation: (1) To perform leading multidisciplinary research in the computing sciences, physical sciences, energy sciences, biosciences, and general sciences in a manner that ensures employee and public safety and protection of the environment. (2) To develop and operate unique national experimental facilities for qualified investigators. (3) To educate and train future generations of scientists and engineers to promote national science and education goals. (4) To transfer knowledge and technological innovations and to foster productive relationships among Berkeley Lab's research programs, universities, and industry in order to promote national economic competitiveness. This is the annual report on Laboratory Directed Research and Development (LDRD) program for FY01.

  8. Decommissioning of the Fission Product Development Laboratory at Holifield National Laboratory

    International Nuclear Information System (INIS)

    Schaich, R.W.

    1975-01-01

    The decontamination of the Fission Product Development Laboratory was initiated in FY 1975 after 17 years of processing fission product waste streams to produce commercial quantities of 90 Sr, 137 Cs, 144 Ce, and 147 Pm. The objective of the decommissioning program is the removal of all radiation and contamination areas in the facility to a level which will be compatible with the environment in the foreseeable future

  9. Developing a customised approach for strengthening tuberculosis laboratory quality management systems toward accreditation

    Directory of Open Access Journals (Sweden)

    Heidi Albert

    2017-03-01

    Full Text Available Background: Quality-assured tuberculosis laboratory services are critical to achieve global and national goals for tuberculosis prevention and care. Implementation of a quality management system (QMS in laboratories leads to improved quality of diagnostic tests and better patient care. The Strengthening Laboratory Management Toward Accreditation (SLMTA programme has led to measurable improvements in the QMS of clinical laboratories. However, progress in tuberculosis laboratories has been slower, which may be attributed to the need for a structured tuberculosis-specific approach to implementing QMS. We describe the development and early implementation of the Strengthening Tuberculosis Laboratory Management Toward Accreditation (TB SLMTA programme. Development: The TB SLMTA curriculum was developed by customizing the SLMTA curriculum to include specific tools, job aids and supplementary materials specific to the tuberculosis laboratory. The TB SLMTA Harmonized Checklist was developed from the World Health Organisation Regional Office for Africa Stepwise Laboratory Quality Improvement Process Towards Accreditation checklist, and incorporated tuberculosis-specific requirements from the Global Laboratory Initiative Stepwise Process Towards Tuberculosis Laboratory Accreditation online tool. Implementation: Four regional training-of-trainers workshops have been conducted since 2013. The TB SLMTA programme has been rolled out in 37 tuberculosis laboratories in 10 countries using the Workshop approach in 32 laboratories in five countries and the Facility based approach in five tuberculosis laboratories in five countries. Conclusion: Lessons learnt from early implementation of TB SLMTA suggest that a structured training and mentoring programme can build a foundation towards further quality improvement in tuberculosis laboratories. Structured mentoring, and institutionalisation of QMS into country programmes, is needed to support tuberculosis laboratories

  10. 2015 Fermilab Laboratory Directed Research & Development Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Wester, W. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

    2016-05-26

    The Fermi National Accelerator Laboratory (FNAL) is conducting a Laboratory Directed Research and Development (LDRD) program. Fiscal year 2015 represents the first full year of LDRD at Fermilab and includes seven projects approved mid-year in FY14 and six projects approved in FY15. One of the seven original projects has been completed just after the beginning of FY15. The implementation of LDRD at Fermilab is captured in the approved Fermilab 2015 LDRD Annual Program Plan. In FY15, the LDRD program represents 0.64% of Laboratory funding. The scope of the LDRD program at Fermilab will be established over the next couple of years where a portfolio of about 20 on-going projects representing approximately between 1% and 1.5% of the Laboratory funding is anticipated. This Annual Report focuses on the status of the current projects and provides an overview of the current status of LDRD at Fermilab.

  11. Oak Ridge National Laboratory Next Generation Safeguards Initiative

    Energy Technology Data Exchange (ETDEWEB)

    Kirk, Bernadette Lugue [ORNL; Eipeldauer, Mary D [ORNL; Whitaker, J Michael [ORNL

    2011-12-01

    In 2007, the Department of Energy's National Nuclear Security Administration (DOE/NNSA) Office of Nonproliferation and International Security (NA-24) completed a comprehensive review of the current and potential future challenges facing the international safeguards system. The review examined trends and events impacting the mission of international safeguards and the implications of expanding and evolving mission requirements on the legal authorities and institutions that serve as the foundation of the international safeguards system, as well as the technological, financial, and human resources required for effective safeguards implementation. The review's findings and recommendations were summarized in the report, 'International Safeguards: Challenges and Opportunities for the 21st Century (October 2007)'. One of the report's key recommendations was for DOE/NNSA to launch a major new program to revitalize the international safeguards technology and human resource base. In 2007, at the International Atomic Energy Agency's General Conference, then Secretary of Energy Samuel W. Bodman announced the newly created Next Generation Safeguards Initiative (NGSI). NGSI consists of five program elements: (1) Policy development and outreach; (2) Concepts and approaches; (3) Technology and analytical methodologies; (4) Human resource development; and (5) Infrastructure development. The ensuing report addresses the 'Human Resource Development (HRD)' component of NGSI. The goal of the HRD as defined in the NNSA Program Plan (November 2008) is 'to revitalize and expand the international safeguards human capital base by attracting and training a new generation of talent.' One of the major objectives listed in the HRD goal includes education and training, outreach to universities, professional societies, postdoctoral appointments, and summer internships at national laboratories. ORNL is a participant in the NGSI program, together

  12. Reactor safety research and development in Chalk River Laboratories

    Energy Technology Data Exchange (ETDEWEB)

    Nitheanandan, T. [Atomic Energy of Canada Limited, Chalk River, ON (Canada)

    2014-07-01

    Atomic Energy of Canada Limited's Chalk River Laboratories provides three different services to stakeholders and customers. The first service provided by the laboratory is the implementation of Research and Development (R&D) programs to provide the underlying technological basis of safe nuclear power reactor designs. A significant portion of the Canadian R&D capability in reactor safety resides at Atomic Energy of Canada Limited's Chalk River Laboratories, and this capability was instrumental in providing the science and technology required to aid in the safety design of CANDU power reactors. The second role of the laboratory has been in supporting nuclear facility licensees to ensure the continued safe operation of nuclear facilities, and to develop safety cases to justify continued operation. The licensing of plant life extension is a key industry objective, requiring extensive research on degradation mechanisms, such that safety cases are based on the original safety design data and valid and realistic assumptions regarding the effect of ageing and management of plant life. Recently, Chalk River Laboratories has been engaged in a third role in research to provide the technical basis and improved understanding for decision making by regulatory bodies. The state-of-the-art test facilities in Chalk River Laboratories have been contributing to the R&D needs of all three roles, not only in Canada but also in the international community, thorough Canada's participation in cooperative programs lead by International Atomic Energy Agency and the OECD's Nuclear Energy Agency. (author)

  13. Laboratory-Directed Research and Development 2016 Summary Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Pillai, Rekha Sukamar [Idaho National Lab. (INL), Idaho Falls, ID (United States); Jacobson, Julie Ann [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-01-01

    The Laboratory-Directed Research and Development (LDRD) Program at Idaho National Laboratory (INL) reports its status to the U.S. Department of Energy (DOE) by March of each year. The program operates under the authority of DOE Order 413.2C, “Laboratory Directed Research and Development” (April 19, 2006), which establishes DOE’s requirements for the program while providing the laboratory director broad flexibility for program implementation. LDRD funds are obtained through a charge to all INL programs. This report includes summaries of all INL LDRD research activities supported during Fiscal Year (FY) 2016. INL is the lead laboratory for the DOE Office of Nuclear Energy (DOE-NE). The INL mission is to discover, demonstrate, and secure innovative nuclear energy solutions, other clean energy options, and critical infrastructure with a vision to change the world’s energy future and secure our critical infrastructure. Operating since 1949, INL is the nation’s leading research, development, and demonstration center for nuclear energy, including nuclear nonproliferation and physical and cyber-based protection of energy systems and critical infrastructure, as well as integrated energy systems research, development, demonstration, and deployment. INL has been managed and operated by Battelle Energy Alliance, LLC (a wholly owned company of Battelle) for DOE since 2005. Battelle Energy Alliance, LLC, is a partnership between Battelle, BWX Technologies, Inc., AECOM, the Electric Power Research Institute, the National University Consortium (Massachusetts Institute of Technology, Ohio State University, North Carolina State University, University of New Mexico, and Oregon State University), and the Idaho university collaborators (i.e., University of Idaho, Idaho State University, and Boise State University). Since its creation, INL’s research and development (R&D) portfolio has broadened with targeted programs supporting national missions to advance nuclear energy

  14. The effectiveness of newly developed written asthma action plan in improvement of asthma outcome in children.

    Science.gov (United States)

    Lakupoch, Kingthong; Manuyakorn, Wiparat; Preutthipan, Aroonwan; Kamalaporn, Harutai

    2017-09-17

    Providing asthma education about controller medication use and appropriate management of asthma exacerbation are the keys to improving the disease outcome. Many asthma guidelines recommend that physicians provide written asthma action plan (WAAP) to all of their asthmatic patients. However, the benefit of WAAP is unclear. Thus, we have created a new WAAP which is simplified in Thai and more user friendly. To determine the effectiveness of the newly developed asthma action plan in management of children with asthma. Asthmatic children who meet inclusion criteria all received the WAAP and they were followed up for 6 months with measurement of outcome variables, such as asthma exacerbation that required emergency room visit, unscheduled OPD visit, admission and school absence in order to compare with the past 6 months before receiving the WAAP. The analyzed outcomes of forty-nine children show significantly reduced emergency room visit (P-value 0.005), unscheduled OPD visit (P-value 0.046), admission days (P-value 0.026) and school absence days (P-value 0.022). Well controlled group and mild severity group were not the factors that contribute to decreased emergency room visit but step up therapy may be the co-factor to decreased ER visit. The results of this study suggest that the provision of newly developed WAAP is useful for improving self-care of asthma patients and reducing asthma exacerbation.

  15. Alterations found with computerized tomography in newly diagnosed type 2 diabetics

    International Nuclear Information System (INIS)

    Bruna, J.

    1989-01-01

    In 28 newly diagnosed type 2 diabetic patients (insulin-independent), computerized tomography (CT) was used to determine the density of the pancreas and the kidneys, densities of the liver, spleen and blood in the abdominal aorta, and to investigate pathological changes in the tissues mentioned above. The results were correlated with laboratory findings. The following changes were found: decreased density of the pancreas (29.4 H) and the liver (49.1 H) and increased density of the spleen (56.3 H) and blood in the abdominal aorta (43.7 H). The decreased density of the pancreas appears to be connected with disorders of lipoprotein metabolism. The decreased liver density was related to increased energy intake by food and to overweight evaluated by Broc's index. Other CT findings in the newly diagnosed type 2 diabetics (changes in the size of the pancreas, and kidneys, kidney cysts, nephrolithiasis, sclerotic plaques on aorta) were not significant. (author). 2 tabs., 11 refs

  16. Pre Incident Planning For The Los Alamos National Laboratory

    Science.gov (United States)

    2017-12-01

    laboratory was asked to design and build the world’s first atomic bomb . The Los Alamos Fire Department (LAFD) provides emergency response services to...Project: the newly established laboratory was asked to design and build the world’s first atomic bomb . The Los Alamos Fire Department (LAFD) provides...lower priority despite its importance to the responders’ scene safety.20 In a Carolina Fire Rescue EMS Journal article, retired New York City

  17. Laboratory development of methods for centralized treatment of liquid low-level waste at Oak Ridge National Laboratory

    International Nuclear Information System (INIS)

    Arnold, W.D.; Bostick, D.T.; Burgess, M.W.; Taylor, P.A.; Perona, J.J.; Kent, T.E.

    1994-10-01

    Improved centralized treatment methods are needed in the management of liquid low-level waste (LLLW) at Oak Ridge National Laboratory (ORNL). LLLW, which usually contains radioactive contaminants at concentrations up to millicurie-per-liter levels, has accumulated in underground storage tanks for over 10 years and has reached a volume of over 350,000 gal. These wastes have been collected since 1984 and are a complex mixture of wastes from past nuclear energy research activities. The waste is a highly alkaline 4-5 M NaNO 3 solution with smaller amounts of other salts. This type of waste will continue to be generated as a consequence of future ORNL research programs. Future LLLW (referred to as newly generated LLLW or NGLLLW) is expected to a highly alkaline solution of sodium carbonate and sodium hydroxide with a smaller concentration of sodium nitrate. New treatment facilities are needed to improve the manner in which these wastes are managed. These facilities must be capable of separating and reducing the volume of radioactive contaminants to small stable waste forms. Treated liquids must meet criteria for either discharge to the environment or solidification for onsite disposal. Laboratory testing was performed using simulated waste solutions prepared using the available characterization information as a basis. Testing was conducted to evaluate various methods for selective removal of the major contaminants. The major contaminants requiring removal from Melton Valley Storage Tank liquids are 90 Sr and 137 Cs. Principal contaminants in NGLLLW are 9O Sr, 137 Cs, and 106 Ru. Strontium removal testing began with literature studies and scoping tests with several ion-exchange materials and sorbents

  18. Health and safety in clinical laboratories in developing countries: safety considerations.

    Science.gov (United States)

    Ejilemele, A A; Ojule, A C

    2004-01-01

    Clinical laboratories are potentially hazardous work areas. Health and safety in clinical laboratories is becoming an increasingly important subject as a result of the emergence of highly infectious diseases such as hepatitis and HIV. This is even more so in developing countries where health and safety have traditionally been regarded as low priority issues, considering the more important health problems confronting the health authorities in these countries. We conducted a literature search using the medical subheadings titles on the INTERNET over a period of twenty years and summarized our findings. This article identifies hazards in the laboratories and highlights measures to make the laboratory a safer work place. It also emphasizes the mandatory obligations of employers and employees towards the attainment of acceptable safety standards in clinical laboratories in Third World countries in the face of the current HIV/AIDS epidemic in many of these developing countries especially in the sub-Saharan Africa while accommodating the increasing work load in these laboratories. Both the employer and the employee have major roles to play in the maintenance of a safe working environment. This can be achieved if measures discussed are incorporated into everyday laboratory practice.

  19. Development of performance assessment instrument based contextual learning for measuring students laboratory skills

    Science.gov (United States)

    Susilaningsih, E.; Khotimah, K.; Nurhayati, S.

    2018-04-01

    The assessment of laboratory skill in general hasn’t specific guideline in assessment, while the individual assessment of students during a performance and skill in performing laboratory is still not been observed and measured properly. Alternative assessment that can be used to measure student laboratory skill is use performance assessment. The purpose of this study was to determine whether the performance assessment instrument that the result of research can be used to assess basic skills student laboratory. This research was conducted by the Research and Development. The result of the data analysis performance assessment instruments developed feasible to implement and validation result 62.5 with very good categories for observation sheets laboratory skills and all of the components with the very good category. The procedure is the preliminary stages of research and development stages. Preliminary stages are divided in two, namely the field studies and literature studies. The development stages are divided into several parts, namely 1) development of the type instrument, 2) validation by an expert, 3) a limited scale trial, 4) large-scale trials and 5) implementation of the product. The instrument included in the category of effective because 26 from 29 students have very high laboratory skill and high laboratory skill. The research of performance assessment instrument is standard and can be used to assess basic skill student laboratory.

  20. Laboratory Directed Research and Development Program FY2016 Annual Summary of Completed Projects

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2017-03-30

    ORNL FY 2016 Annual Summary of Laboratory Directed Research and Development Program (LDRD) Completed Projects. The Laboratory Directed Research and Development (LDRD) program at ORNL operates under the authority of DOE Order 413.2C, “Laboratory Directed Research and Development” (October 22, 2015), which establishes DOE’s requirements for the program while providing the Laboratory Director broad flexibility for program implementation. The LDRD program funds are obtained through a charge to all Laboratory programs. ORNL reports its status to DOE in March of each year.

  1. Laboratory Directed Research and Development Program Assessment for FY 2014

    Energy Technology Data Exchange (ETDEWEB)

    Hatton, D. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2014-03-01

    Each year, Brookhaven National Laboratory (BNL) is required to provide a program description and overview of its Laboratory Directed Research and Development Program (LDRD) to the Department of Energy in accordance with DOE Order 413.2B dated April 19, 2006. This report fulfills that requirement.

  2. LABORATORY DIRECTED RESEARCH AND DEVELOPMENT PROGRAM ACTIVITIES FOR FY2002.

    Energy Technology Data Exchange (ETDEWEB)

    FOX,K.J.

    2002-12-31

    Brookhaven National (BNL) Laboratory is a multidisciplinary laboratory that carries out basic and applied research in the physical, biomedical, and environmental sciences, and in selected energy technologies. It is managed by Brookhaven Science Associates, LLC, under contract with the U. S. Department of Energy. BNL's total annual budget has averaged about $450 million. There are about 3,000 employees, and another 4,500 guest scientists and students who come each year to use the Laboratory's facilities and work with the staff. The BNL Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) annually in March, as required by DOE Order 4 1 3.2A, ''Laboratory Directed Research and Development,'' January 8, 2001, and the LDRD Annual Report guidance, updated February 12, 1999. The LDRD Program obtains its funds through the Laboratory overhead pool and operates under the authority of DOE Order 413.2A. The goals and objectives of BNL's LDRD Program can be inferred from the Program's stated purposes. These are to (1) encourage and support the development of new ideas and technology, (2) promote the early exploration and exploitation of creative and innovative concepts, and (3) develop new ''fundable'' R&D projects and programs. The emphasis is clearly articulated by BNL to be on supporting exploratory research ''which could lead to new programs, projects, and directions'' for the Laboratory. As one of the premier scientific laboratories of the DOE, BNL must continuously foster groundbreaking scientific research. At Brookhaven National Laboratory one such method is through its LDRD Program. This discretionary research and development tool is critical in maintaining the scientific excellence and long-term vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community and foster new science and technology

  3. Laboratory Impact Experiments

    Science.gov (United States)

    Horanyi, M.; Munsat, T.

    2017-12-01

    The experimental and theoretical programs at the SSERVI Institute for Modeling Plasmas, Atmospheres, and Cosmic Dust (IMPACT) address the effects of hypervelocity dust impacts and the nature of the space environment of granular surfaces interacting with solar wind plasma and ultraviolet radiation. These are recognized as fundamental planetary processes due their role in shaping the surfaces of airless planetary objects, their plasma environments, maintaining dust haloes, and sustaining surface bound exospheres. Dust impacts are critically important for all airless bodies considered for possible human missions in the next decade: the Moon, Near Earth Asteroids (NEAs), Phobos, and Deimos, with direct relevance to crew and mission safety and our ability to explore these objects. This talk will describe our newly developed laboratory capabilities to assess the effects of hypervelocity dust impacts on: 1) the gardening and redistribution of dust particles; and 2) the generation of ionized and neutral gasses on the surfaces of airless planetary bodies.

  4. 2015 Fermilab Laboratory Directed Research & Development Program Plan

    Energy Technology Data Exchange (ETDEWEB)

    Wester, W., editor

    2015-05-26

    Fermilab is executing Laboratory Directed Research and Development (LDRD) as outlined by order DOE O 413.2B in order to enhance and realize the mission of the laboratory in a manner that also supports the laboratory’s strategic objectives and the mission of the Department of Energy. LDRD funds enable scientific creativity, allow for exploration of “high risk, high payoff” research, and allow for the demonstration of new ideas, technical concepts, and devices. LDRD also has an objective of maintaining and enhancing the scientific and technical vitality of Fermilab.

  5. 2014 Fermilab Laboratory Directed Research & Development Program Plan

    Energy Technology Data Exchange (ETDEWEB)

    Wester, W., editor

    2016-05-26

    Fermilab is executing Laboratory Directed Research and Development (LDRD) as outlined by order DOE O 413.2B in order to enhance and realize the mission of the laboratory in a manner that also supports the laboratory’s strategic objectives and the mission of the Department of Energy. LDRD funds enable scientific creativity, allow for exploration of “high risk, high payoff” research, and allow for the demonstration of new ideas, technical concepts, and devices. LDRD also has an objective of maintaining and enhancing the scientific and technical vitality of Fermilab.

  6. An overview of the waste characterization program at Chalk River Nuclear Laboratories

    International Nuclear Information System (INIS)

    Csullog, G.W.; Hardy, D.G.

    1990-05-01

    A comprehensive Waste Characterization Program (WCP) is in place at Chalk River Laboratories to support disposal projects. The WCP is responsible for: 1) specifying the manifests for waste shipments; 2) developing and maintaining central databases for waste inventories and analytical data; and 3) developing the technologies and procedures to characterize the radiological and the physical/chemical properties of wastes. WCP work is being performed under the umbrella of a newly developed waste management Quality Assurance (QA) program. This paper gives an overview of the WCP with an emphasis on the requirements for determining radionuclide inventories in wastes, for implementing record-keeping systems, and for maintaining a QA program for disposal operations

  7. Continuing professional development training needs of medical laboratory personnel in Botswana.

    Science.gov (United States)

    Kasvosve, Ishmael; Ledikwe, Jenny H; Phumaphi, Othilia; Mpofu, Mulamuli; Nyangah, Robert; Motswaledi, Modisa S; Martin, Robert; Semo, Bazghina-Werq

    2014-08-18

    Laboratory professionals are expected to maintain their knowledge on the most recent advances in laboratory testing and continuing professional development (CPD) programs can address this expectation. In developing countries, accessing CPD programs is a major challenge for laboratory personnel, partly due to their limited availability. An assessment was conducted among clinical laboratory workforce in Botswana to identify and prioritize CPD training needs as well as preferred modes of CPD delivery. A self-administered questionnaire was disseminated to medical laboratory scientists and technicians registered with the Botswana Health Professions Council. Questions were organized into domains of competency related to (i) quality management systems, (ii) technical competence, (iii) laboratory management, leadership, and coaching, and (iv) pathophysiology, data interpretation, and research. Participants were asked to rank their self-perceived training needs using a 3-point scale in order of importance (most, moderate, and least). Furthermore, participants were asked to select any three preferences for delivery formats for the CPD. Out of 350 questionnaires that were distributed, 275 were completed and returned giving an overall response rate of 79%. The most frequently selected topics for training in rank order according to key themes were (mean, range) (i) quality management systems, most important (79%, 74-84%); (ii) pathophysiology, data interpretation, and research (68%, 52-78%); (iii) technical competence (65%, 44-73%); and (iv) laboratory management, leadership, and coaching (60%, 37-77%). The top three topics selected by the participants were (i) quality systems essentials for medical laboratory, (ii) implementing a quality management system, and (iii) techniques to identify and control sources of error in laboratory procedures. The top three preferred CPD delivery modes, in rank order, were training workshops, hands-on workshops, and internet-based learning

  8. Conventional and improved cytotoxicity test methods of newly developed biodegradable magnesium alloys

    Science.gov (United States)

    Han, Hyung-Seop; Kim, Hee-Kyoung; Kim, Yu-Chan; Seok, Hyun-Kwang; Kim, Young-Yul

    2015-11-01

    Unique biodegradable property of magnesium has spawned countless studies to develop ideal biodegradable orthopedic implant materials in the last decade. However, due to the rapid pH change and extensive amount of hydrogen gas generated during biocorrosion, it is extremely difficult to determine the accurate cytotoxicity of newly developed magnesium alloys using the existing methods. Herein, we report a new method to accurately determine the cytotoxicity of magnesium alloys with varying corrosion rate while taking in-vivo condition into the consideration. For conventional method, extract quantities of each metal ion were determined using ICP-MS and the result showed that the cytotoxicity due to pH change caused by corrosion affected the cell viability rather than the intrinsic cytotoxicity of magnesium alloy. In physiological environment, pH is regulated and adjusted within normal pH (˜7.4) range by homeostasis. Two new methods using pH buffered extracts were proposed and performed to show that environmental buffering effect of pH, dilution of the extract, and the regulation of eluate surface area must be taken into consideration for accurate cytotoxicity measurement of biodegradable magnesium alloys.

  9. Final Report National Laboratory Professional Development Workshop for Underrepresented Participants

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, Valerie [Texas Engineering Experiment Station, College Station, TX (United States)

    2016-11-07

    The 2013 CMD-IT National Laboratories Professional Development Workshop for Underrepresented Participants (CMD-IT NLPDev 2013) was held at the Oak Ridge National Laboratory campus in Oak Ridge, TN. from June 13 - 14, 2013. Sponsored by the Department of Energy (DOE) Advanced Scientific Computing Research Program, the primary goal of these workshops is to provide information about career opportunities in computational science at the various national laboratories and to mentor the underrepresented participants through community building and expert presentations focused on career success. This second annual workshop offered sessions to facilitate career advancement and, in particular, the strategies and resources needed to be successful at the national laboratories.

  10. [The 1, 2, 3 of laboratory animal experimentation].

    Science.gov (United States)

    Romero-Fernandez, Wilber; Batista-Castro, Zenia; De Lucca, Marisel; Ruano, Ana; García-Barceló, María; Rivera-Cervantes, Marta; García-Rodríguez, Julio; Sánchez-Mateos, Soledad

    2016-06-01

    The slow scientific development in Latin America in recent decades has delayed the incorporation of laboratory animal experimentation; however, this situation has started to change. Today, extraordinary scientific progress is evident, which has promoted the introduction and increased use of laboratory animals as an important tool for the advancement of biomedical sciences. In the aftermath of this boom, the need to provide the scientific community with training and guidance in all aspects related to animal experimentation has arisen. It is the responsibility of each country to regulate this practice, for both bioethical and legal reasons, to ensure consideration of the animals' rights and welfare. The following manuscript is the result of papers presented at the International Workshop on Laboratory Animal Testing held at the Technical University of Ambato, Ecuador; it contains information regarding the current state of affairs in laboratory animal testing and emphasizes critical aspects such as main species used, ethical and legal principles, and experimental and alternative designs for animal use. These works aim to ensure good practices that should define scientific work. This document will be relevant to both researchers who aim to newly incorporate animal testing into their research and those who seek to update their knowledge.

  11. Evaluation of Shielding Performance for Newly Developed Composite Materials

    Science.gov (United States)

    Evans, Beren Richard

    This work details an investigation into the contributing factors behind the success of newly developed composite neutron shield materials. Monte Carlo simulation methods were utilized to assess the neutron shielding capabilities and secondary radiation production characteristics of aluminum boron carbide, tungsten boron carbide, bismuth borosilicate glass, and Metathene within various neutron energy spectra. Shielding performance and secondary radiation data suggested that tungsten boron carbide was the most effective composite material. An analysis of the macroscopic cross-section contributions from constituent materials and interaction mechanisms was then performed in an attempt to determine the reasons for tungsten boron carbide's success over the other investigated materials. This analysis determined that there was a positive correlation between a non-elastic interaction contribution towards a material's total cross-section and shielding performance within the thermal and epi-thermal energy regimes. This finding was assumed to be a result of the boron-10 absorption reaction. The analysis also determined that within the faster energy regions, materials featuring higher non-elastic interaction contributions were comparable to those exhibiting primarily elastic scattering via low Z elements. This allowed for the conclusion that composite shield success within higher energy neutron spectra does not necessitate the use elastic scattering via low Z elements. These findings suggest that the inclusion of materials featuring high thermal absorption properties is more critical to composite neutron shield performance than the presence of constituent materials more inclined to maximize elastic scattering energy loss.

  12. DTU PMU Laboratory Development - Testing and Validation

    OpenAIRE

    Garcia-Valle, Rodrigo; Yang, Guang-Ya; Martin, Kenneth E.; Nielsen, Arne Hejde; Østergaard, Jacob

    2010-01-01

    This is a report of the results of phasor measurement unit (PMU) laboratory development and testing done at the Centre for Electric Technology (CET), Technical University of Denmark (DTU). Analysis of the PMU performance first required the development of tools to convert the DTU PMU data into IEEE standard, and the validation is done for the DTU-PMU via a validated commercial PMU. The commercial PMU has been tested from the authors' previous efforts, where the response can be expected to foll...

  13. Chemical reactor development : from laboratory synthesis to industrial production

    NARCIS (Netherlands)

    Thoenes, D.

    1998-01-01

    Chemical Reactor Development is written primarily for chemists and chemical engineers who are concerned with the development of a chemical synthesis from the laboratory bench scale, where the first successful experiments are performed, to the design desk, where the first commercial reactor is

  14. Individual consistency in the behaviors of newly-settled reef fish.

    Science.gov (United States)

    White, James R; Meekan, Mark G; McCormick, Mark I

    2015-01-01

    Flexibility in behavior is advantageous for organisms that transition between stages of a complex life history. However, various constraints can set limits on plasticity, giving rise to the existence of personalities that have associated costs and benefits. Here, we document a field and laboratory experiment that examines the consistency of measures of boldness, activity, and aggressive behavior in the young of a tropical reef fish, Pomacentrus amboinensis (Pomacentridae) immediately following their transition between pelagic larval and benthic juvenile habitats. Newly-settled fish were observed in aquaria and in the field on replicated patches of natural habitat cleared of resident fishes. Seven behavioral traits representing aspects of boldness, activity and aggression were monitored directly and via video camera over short (minutes), medium (hours), and long (3 days) time scales. With the exception of aggression, these behaviors were found to be moderately or highly consistent over all time scales in both laboratory and field settings, implying that these fish show stable personalities within various settings. Our study is the first to examine the temporal constancy of behaviors in both field and laboratory settings in over various time scales at a critically important phase during the life cycle of a reef fish.

  15. Radioactive target and source development at Argonne National Laboratory

    International Nuclear Information System (INIS)

    Greene, J.P.; Ahmad, I.; Thomas, G.E.

    1992-01-01

    An increased demand for low-level radioactive targets has created the need for a laboratory dedicated to the production of these foils. A description is given of the radioactive target produced as well as source development work being performed at the Physics Division target facility of Argonne National Laboratory (ANL). Highlights include equipment used and the techniques employed. In addition, some examples of recent source preparation are given as well as work currently in progress

  16. Laboratory directed research and development 2006 annual report.

    Energy Technology Data Exchange (ETDEWEB)

    Westrich, Henry Roger

    2007-03-01

    This report summarizes progress from the Laboratory Directed Research and Development (LDRD) program during fiscal year 2006. In addition to a programmatic and financial overview, the report includes progress reports from 430 individual R&D projects in 17 categories.

  17. Micromachined sensor and actuator research at Sandia`s Microelectronics Development Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Smith, J.H.

    1996-11-01

    An overview of the surface micromachining program at the Microelectronics Development Laboratory of Sandia National Laboratories is presented. Development efforts are underway for a variety of surface micromachined sensors and actuators for both defense and commercial applications. A technology that embeds micromechanical devices below the surface of the wafer prior to microelectronics fabrication has been developed for integrating microelectronics with surface-micromachined micromechanical devices. The application of chemical-mechanical polishing to increase the manufacturability of micromechanical devices is also presented.

  18. Laboratory directed research and development: Annual report to the Department of Energy

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-01

    As one of the premier scientific laboratories of the DOE, Brookhaven must continuously foster the development of new ideas and technologies, promote the early exploration and exploitation of creative and innovative concepts, and develop new fundable R and D projects and programs. At Brookhaven National Laboratory one such method is through its Laboratory Directed Research and Development Program. This discretionary research and development tool is critical in maintaining the scientific excellence and long-term vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community, fostering new science and technology ideas, which is a major factor in achieving and maintaining staff excellence and a means to address national needs within the overall mission of the DOE and BNL. The Project Summaries with their accomplishments are described in this report. Aside from leading to new fundable or promising programs and producing especially noteworthy research, they have resulted in numerous publications in various professional and scientific journals and presentations at meetings and forums.

  19. Laboratory directed research and development annual report. Fiscal year 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-02-01

    The Department of Energy Order DOE 5000.4A establishes DOE`s policy and guidelines regarding Laboratory Directed Research and Development (LDRD) at its multiprogram laboratories. This report represents Pacific Northwest Laboratory`s (PNL`s) LDRD report for FY 1994. During FY 1994, 161 LDRD projects were selected for support through PNL`s LDRD project selection process. Total funding allocated to these projects was $13.7 million. Consistent with the Mission Statement and Strategic Plan provided in PNL`s Institutional Plan, the LDRD investments are focused on developing new and innovative approaches in research related to our {open_quotes}core competencies.{close_quotes} Currently, PNL`s core competencies have been identified as integrated environmental research; process science and engineering; energy systems development. In this report, the individual summaries of LDRD projects (presented in Section 1.0) are organized according to these core competencies. The largest proportion of Laboratory-level LDRD funds is allocated to the core competency of integrated environmental research. Projects within the three core competency areas were approximately 91.4 % of total LDRD project funding at PNL in FY 1994. A significant proportion of PNL`s LDRD funds are also allocated to projects within the various research centers that are proposed by individual researchers or small research teams. Funding allocated to each of these projects is typically $35K or less. The projects described in this report represent PNL`s investment in its future and are vital to maintaining the ability to develop creative solutions for the scientific and technical challenges faced by DOE and the nation. The report provides an overview of PNL`s LDRD program, the management process used for the program, and project summaries for each LDRD project.

  20. Idaho National Engineering Laboratory site development plan

    International Nuclear Information System (INIS)

    1994-09-01

    This plan briefly describes the 20-year outlook for the Idaho National Engineering Laboratory (INEL). Missions, workloads, worker populations, facilities, land, and other resources necessary to fulfill the 20-year site development vision for the INEL are addressed. In addition, the plan examines factors that could enhance or deter new or expanded missions at the INEL. And finally, the plan discusses specific site development issues facing the INEL, possible solutions, resources required to resolve these issues, and the anticipated impacts if these issues remain unresolved

  1. Laboratory Directed Research and Development Program: FY 2015 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    SLAC,

    2016-04-04

    The Department of Energy (DOE) and the SLAC National Accelerator Laboratory (SLAC) encourage innovation, creativity, originality and quality to maintain the Laboratory’s research activities and staff at the forefront of science and technology. To further advance its scientific research capabilities, the Laboratory allocates a portion of its funds for the Laboratory Directed Research and Development (LDRD) program. With DOE guidance, the LDRD program enables SLAC scientists to make rapid and significant contributions that seed new strategies for solving important national science and technology problems. The LDRD program is conducted using existing research facilities.

  2. Quality assurance in a large research and development laboratory

    International Nuclear Information System (INIS)

    Neill, F.H.

    1980-01-01

    Developing a quality assurance program for a large research and development laboratory provided a unique opportunity for innovative planning. The quality assurance program that emerged has been tailored to meet the requirements of several sponsoring organizations and contains the flexibility for experimental programs ranging from large engineering-scale development projects to bench-scale basic research programs

  3. Combustion, performance and emissions characteristics of a newly ...

    Indian Academy of Sciences (India)

    of a newly developed CRDI single cylinder diesel engine. AVINASH ... In case of unit injector and unit pump systems, fuel injection pressure depends on ... nozzle hole diameters were effective in reducing smoke and PM emissions. However ...

  4. Idaho National Laboratory - Nuclear Research Center

    International Nuclear Information System (INIS)

    Zaidi, M.K.

    2005-01-01

    Full text: The Idaho National Laboratory is committed to the providing international nuclear leadership for the 21st Century, developing and demonstrating compiling national security technologies, and delivering excellence in science and technology as one of the United States Department of Energy's (DOE) multiprogram national laboratories. INL runs three major programs - Nuclear, Security and Science. nuclear programs covers the Advanced test reactor, Six Generation technology concepts selected for R and D, Targeting tumors - Boron Neutron capture therapy. Homeland security - Homeland Security establishes the Control System Security and Test Center, Critical Infrastructure Test Range evaluates technologies on a scalable basis, INL conducts high performance computing and visualization research and science - INL facility established for Geocentrifuge Research, Idaho Laboratory, a Utah company achieved major milestone in hydrogen research and INL uses extremophile bacteria to ease bleaching's environmental cost. To provide leadership in the education and training, INL has established an Institute of Nuclear Science and Engineering (Inset). The institute will offer a four year degree based on a newly developed curriculum - two year of basic science course work and two years of participation in project planning and development. The students enrolled in this program can continue to get a masters or a doctoral degree. This summer Inset is the host for the training of the first international group selected by the World Nuclear University (WNU) - 75 fellowship holders and their 30 instructors from 40 countries. INL has been assigned to provide future global leadership in the field of nuclear science and technology. Here, at INL, we keep safety first above all things and our logo is 'Nuclear leadership synonymous with safety leadership'

  5. A Radiation Laboratory Curriculum Development at Western Kentucky University

    International Nuclear Information System (INIS)

    Barzilov, Alexander P.; Novikov, Ivan S.; Womble, Phil C.

    2009-01-01

    We present the latest developments for the radiation laboratory curriculum at the Department of Physics and Astronomy of Western Kentucky University. During the last decade, the Applied Physics Institute (API) at WKU accumulated various equipment for radiation experimentation. This includes various neutron sources (computer controlled d-t and d-d neutron generators, and isotopic 252 Cf and PuBe sources), the set of gamma sources with various intensities, gamma detectors with various energy resolutions (NaI, BGO, GSO, LaBr and HPGe) and the 2.5-MeV Van de Graaff particle accelerator. XRF and XRD apparatuses are also available for students and members at the API. This equipment is currently used in numerous scientific and teaching activities. Members of the API also developed a set of laboratory activities for undergraduate students taking classes from the physics curriculum (Nuclear Physics, Atomic Physics, and Radiation Biophysics). Our goal is to develop a set of radiation laboratories, which will strengthen the curriculum of physics, chemistry, geology, biology, and environmental science at WKU. The teaching and research activities are integrated into real-world projects and hands-on activities to engage students. The proposed experiments and their relevance to the modern status of physical science are discussed.

  6. The use of newly developed real-time PCR for the rapid identification of bacteria in culture-negative osteomyelitis.

    Science.gov (United States)

    Kobayashi, Naomi; Bauer, Thomas W; Sakai, Hiroshige; Togawa, Daisuke; Lieberman, Isador H; Fujishiro, Takaaki; Procop, Gary W

    2006-12-01

    We report a case of a culture-negative osteomyelitis in which our newly developed real-time polymerase chain reaction (PCR) could differentiate Staphylococcus aureus from Staphylococcus epidermidis. This is the first report that described the application of this novel assay to an orthopedics clinical sample. This assay may be useful for other clinical culture-negative cases in a combination with a broad-spectrum assay as a rapid microorganism identification method.

  7. Perceptions of the clinical competence of newly registered nurses in the North West province

    Directory of Open Access Journals (Sweden)

    M.R. Moeti

    2004-09-01

    Full Text Available The clinical competence of newly registered nurses relating to the care of individual Clients, depends on their ability to correlate theoretical knowledge learned in the classroom with practice and the development of clinical skills. Its foundation lies in the ability to identify and solve problems that emanate from critical thinking, analytical reasoning and reflective practice. It is clear that the quality of clinical exposure plays a leading role in the development of nursing professionals. Nursing skills alone cannot ensure quality care of clients without the application of theory. Facilitation of this theory to practice therefore remains an essential component of nursing education. This study was aimed at identifying areas of incompetence of newly registered nurses (1998- 2001 in the clinical area by determining the newly registered nurses1 and professional nurses1 perceptions of the competence of the newly registered nurses. A quantitative, non-experimental, descriptive survey was used to collect the data regarding the clinical competence of newly registered nurses (1998-2001.

  8. Photovoltaic module certification/laboratory accreditation criteria development: Implementation handbook

    Energy Technology Data Exchange (ETDEWEB)

    Osterwald, C.R. [National Renewable Energy Laboratory, Golden, CO (United States); Hammond, R.L.; Wood, B.D.; Backus, C.E.; Sears, R.L. [Arizona State Univ., Tempe, AZ (United States); Zerlaut, G.A. [SC-International, Inc., Tempe, AZ (United States); D`Aiello, R.V. [RD Associates, Tempe, AZ (United States)

    1996-08-01

    This document covers the second phase of a two-part program. Phase I provided an overview of the structure and function of typical product certification/laboratory accreditation programs. This report (Phase H) provides most of the draft documents that will be necessary for the implementation of a photovoltaic (PV) module certification/laboratory accreditation program. These include organizational documents such as articles of incorporation, bylaws, and rules of procedure, as well as marketing and educational program documents. In Phase I, a 30-member criteria development committee was established to guide, review and reach a majority consensus regarding criteria for a PV certification/laboratory accreditation program. Committee members represented PV manufacturers, end users, standards and codes organizations, and testing laboratories. A similar committee was established for Phase II; the criteria implementation committee consisted of 29 members. Twenty-one of the Phase I committee members also served on the Phase II committee, which helped to provide program continuity during Phase II.

  9. 78 FR 28292 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Science.gov (United States)

    2013-05-14

    ... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development Services Scientific Merit Review Board; Notice of Meetings; Amendment The... Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development...

  10. ORNLs Laboratory Directed Research and Development Program FY 2010 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2011-03-01

    The Laboratory Directed Research and Development (LDRD) program at Oak Ridge National Laboratory (ORNL) reports its status to the U.S. Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, “Laboratory Directed Research and Development” (April 19, 2006), which establishes DOE’s requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries of all ORNL LDRD research activities supported during FY 2010. The associated FY 2010 ORNL LDRD Self-Assessment (ORNL/PPA-2011/2) provides financial data and an internal evaluation of the program’s management process.

  11. ORNLs Laboratory Directed Research and Development Program FY 2009 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2010-03-01

    The Laboratory Directed Research and Development (LDRD) program at Oak Ridge National Laboratory (ORNL) reports its status to the U.S. Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, “Laboratory Directed Research and Development” (April 19, 2006), which establishes DOE’s requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries all ORNL LDRD research activities supported during FY 2009. The associated FY 2009 ORNL LDRD Self-Assessment (ORNL/PPA-2010/2) provides financial data and an internal evaluation of the program’s management process.

  12. ORNLs Laboratory Directed Research and Development Program FY 2008 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2009-03-01

    The Oak Ridge National Laboratory (ORNL) Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, “Laboratory Directed Research and Development” (April 19, 2006), which establishes DOE’s requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries all ORNL LDRD research activities supported during FY 2008. The associated FY 2008 ORNL LDRD Self-Assessment (ORNL/PPA-2008/2) provides financial data and an internal evaluation of the program’s management process.

  13. ORNLs Laboratory Directed Research and Development Program FY 2013 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2014-03-01

    The Laboratory Directed Research and Development (LDRD) program at Oak Ridge National Laboratory (ORNL) reports its status to the US Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, “Laboratory Directed Research and Development” (April 19, 2006), which establishes DOE’s requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries of all ORNL LDRD research activities supported during FY 2013. The associated FY 2013 ORNL LDRD Self-Assessment (ORNL/PPA-2014/2) provides financial data and an internal evaluation of the program’s management process.

  14. ORNLs Laboratory Directed Research and Development Program FY 2012 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2013-03-01

    The Laboratory Directed Research and Development (LDRD) program at Oak Ridge National Laboratory (ORNL) reports its status to the US Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, “Laboratory Directed Research and Development” (April 19, 2006), which establishes DOE’s requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries of all ORNL LDRD research activities supported during FY 2012. The associated FY 2012 ORNL LDRD Self-Assessment (ORNL/PPA-2012/2) provides financial data and an internal evaluation of the program’s management process.

  15. ORNLs Laboratory Directed Research and Development Program FY 2011 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2012-03-01

    The Laboratory Directed Research and Development (LDRD) program at Oak Ridge National Laboratory (ORNL) reports its status to the U.S. Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, “Laboratory Directed Research and Development” (April 19, 2006), which establishes DOE’s requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries of all ORNL LDRD research activities supported during FY 2011. The associated FY 2011 ORNL LDRD Self-Assessment (ORNL/PPA-2012/2) provides financial data and an internal evaluation of the program’s management process.

  16. Measurement equivalence of the newly developed Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55).

    Science.gov (United States)

    Ferro, Mark A; Goodwin, Shane W; Sabaz, Mark; Speechley, Kathy N

    2016-03-01

    The aim of this study was to examine measurement equivalence of the newly developed Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55) across age, sex, and time in a representative sample of children with newly diagnosed epilepsy. Data come from 373 children enrolled in the Health-related Quality of Life in Children with Epilepsy Study (HERQULES), a multisite prospective cohort study. Measurement equivalence was examined using a multiple-group confirmatory factor analysis framework, whereby increasingly stringent parameter constraints are imposed on the model. Comparison groups were stratified based on age (4-7 years vs. 8-12 years), sex (male vs. female), and time (measurement of health-related quality of life at diagnosis vs. 24 months later). The QOLCE-55 demonstrated measurement equivalence at the level of strict invariance for each model tested--age: χ(2) (3,123) = 4,097.3, p QOLCE-55 are perceived similarly among groups stratified by age, sex, and time and provide further evidence supporting the validity of the scale in children with epilepsy. Health professionals and researchers should be confident that group comparisons made using the QOLCE-55 are unbiased and that any group differences detected are meaningful; that is, not related to differences in the interpretation of items by informants. Future research replicating these findings is encouraged. Wiley Periodicals, Inc. © 2016 International League Against Epilepsy.

  17. Practicing on Newly Dead

    Directory of Open Access Journals (Sweden)

    Jewel Abraham

    2015-07-01

    Full Text Available A newly dead cadaver simulation is practiced on the physical remains of the dead before the onset of rigor mortis. This technique has potential benefits for providing real-life in-situ experience for novice providers in health care practices. Evolving ethical views in health care brings into question some of the ethical aspects associated with newly dead cadaver simulation in terms of justification for practice, autonomy, consent, and the need of disclosure. A clear statement of policies and procedures on newly dead cadaver simulation has yet to be implemented. Although there are benefits and disadvantages to an in-situ cadaver simulation, such practices should not be carried out in secrecy as there is no compelling evidence that suggests such training as imperative. Secrecy in these practices is a violation of honor code of nursing ethics. As health care providers, practitioners are obliged to be ethically honest and trustworthy to their patients. The author explores the ethical aspects of using newly dead cadaver simulation in training novice nursing providers to gain competency in various lifesaving skills, which otherwise cannot be practiced on a living individual. The author explores multiple views on cadaver simulation in relation to ethical theories and practices such as consent and disclosure to family.

  18. Newly qualified teachers´ possibilities to get foothold in a lifelong career course

    DEFF Research Database (Denmark)

    Krøjgaard, Frede; Frederiksen, Lisbeth Angela Lunde

    Keyword: Induction program, newly qualified teachers, NQT, retention, professional development In Contrary to many other countries in Europe Denmark does not have any kind of national program regarding teacher induction program (TIP) or support in general to newly qualified teachers what so ever...

  19. The practical skills of newly qualified nurses.

    Science.gov (United States)

    Danbjørg, Dorthe Boe; Birkelund, Regner

    2011-02-01

    This paper reports the findings from a study of newly qualified nurses and which subjects the nurses regarded as the most important in order to be able to live up to the requirements of clinical practice, and how they experience their potential for developing practical and moral skills, after the decrease in practical training. A qualitative approach guided the research process and the analysis of the data. The data was collected by participant observation and qualitative interviews with four nurses as informants. The conclusions made in this study are based on the statements and the observations of the newly qualified nurses. Our findings are discussed in relation to the Aristotelian concept and other relevant literature. The main message is that the newly qualified nurses did not feel equipped when they finished their training. This could be interpreted as a direct consequence of the decrease in practical training. Our study also underlines that the way nursing theory is perceived and taught is problematic. The interviews revealed that the nurses think that nursing theories should be applied directly in practice. This misunderstanding is probably also applicable to the teachers of the theories. Copyright © 2010 Elsevier Ltd. All rights reserved.

  20. Comparison of newly developed anti-bone morphogenetic protein 4 llama-derived antibodies with commercially available BMP4 inhibitors.

    Science.gov (United States)

    Calpe, Silvia; Correia, Ana C P; Sancho-Serra, Maria Del Carmen; Krishnadath, Kausilia K

    2016-01-01

    Due to improved understanding of the role of bone morphogenetic protein 4 (BMP4) in an increasing number of diseases, the development of selective inhibitors of BMP4 is an attractive therapeutic option. The currently available BMP4 inhibitors are not suitable as therapeutics because of their low specificity and low effectiveness. Here, we compared newly generated anti-BMP4 llama-derived antibodies (VHHs) with 3 different types of commercially available BMP4 inhibitors, natural antagonists, small molecule BMPR inhibitors and conventional anti-BMP4 monoclonal antibodies. We found that the anti-BMP4 VHHs were as effective as the natural antagonist or small molecule inhibitors, but had higher specificity. We also showed that commercial anti-BMP4 antibodies were inferior in terms of both specificity and effectiveness. These findings might result from the fact that the VHHs C4C4 and C8C8 target a small region within the BMPR1 epitope of BMP4, whereas the commercial antibodies target other areas of the BMP4 molecule. Our results show that the newly developed anti-BMP4 VHHs are promising antibodies with better specificity and effectivity for inhibition of BMP4, making them an attractive tool for research and for therapeutic applications.

  1. Development of a framework for identification of political environmental issues faced by multinational hotel chains in newly industrialized countries in Asia

    OpenAIRE

    Kim, Chol Yong

    1992-01-01

    The primary/objective of this study was to develop a framework for identification of political environmental issues faced by multinational hotel chains in newly industrialized countries in Asia. To accomplish the objective, key factors having an impact upon these hotel chains were identified using the Delphi Technique.

  2. Laboratory directed research and development FY91

    International Nuclear Information System (INIS)

    Anderson, S.E.; Hedman, I.; Kirvel, R.D.; McGregor, C.K.

    1991-01-01

    This review of research programs at Lawrence Livermore National Laboratory is composed of individual papers on various subjects. Broad topics of interest are: chemistry and materials science, computation, earth sciences, engineering, nuclear physics, and physics, and biology. Director's initiatives include the development of a transgenic mouse, accelerator mass spectrometry, high-energy physics detectors, massive parallel computing, astronomical telescopes, the Kuwaiti oil fires and a compact torus accelerator

  3. Re-Development of Radiocarbon Dating Laboratory in Malaysian Nuclear Agency

    International Nuclear Information System (INIS)

    Norfaizal Mohamed; Nita Salina Abu Bakar; Phillip, E.

    2015-01-01

    Nuclear Dating Laboratory, formerly known as Radiocarbon Laboratory was established in Malaysian Nuclear Agency (Nuclear Malaysia) since 1983. A benzene synthesis line for radiocarbon (carbon-14) dating was installed in this laboratory by Australian Atomic Energy Commission (AAEC) under the Hydrology Isotope Project, a collaboration project between IAEA, AAEC and PUSPATI (former name for Nuclear Malaysia). Determining the age of samples could be performed using this facility throughout two main processes, namely the production of benzene containing C-14 isotopes and activity determination of C-14 using Liquid Scintillation Counter. Realizing the need and importance of Nuclear Dating Laboratory for the nations science and technology development, the Top Management of Nuclear Malaysia was agreed to hand over this laboratory and its facilities to Waste Technology and Environmental Division (BAS) started in June 2013 for the redevelopment. Hence, this paper will highlight the weaknesses and problems that need to be addressed and improved to enable it to be used in providing a good service. (author)

  4. ASVCP quality assurance guidelines: control of general analytical factors in veterinary laboratories.

    Science.gov (United States)

    Flatland, Bente; Freeman, Kathy P; Friedrichs, Kristen R; Vap, Linda M; Getzy, Karen M; Evans, Ellen W; Harr, Kendal E

    2010-09-01

    Owing to lack of governmental regulation of veterinary laboratory performance, veterinarians ideally should demonstrate a commitment to self-monitoring and regulation of laboratory performance from within the profession. In response to member concerns about quality management in veterinary laboratories, the American Society for Veterinary Clinical Pathology (ASVCP) formed a Quality Assurance and Laboratory Standards (QAS) committee in 1996. This committee recently published updated and peer-reviewed Quality Assurance Guidelines on the ASVCP website. The Quality Assurance Guidelines are intended for use by veterinary diagnostic laboratories and veterinary research laboratories that are not covered by the US Food and Drug Administration Good Laboratory Practice standards (Code of Federal Regulations Title 21, Chapter 58). The guidelines have been divided into 3 reports on 1) general analytic factors for veterinary laboratory performance and comparisons, 2) hematology and hemostasis, and 3) clinical chemistry, endocrine assessment, and urinalysis. This report documents recommendations for control of general analytical factors within veterinary clinical laboratories and is based on section 2.1 (Analytical Factors Important In Veterinary Clinical Pathology, General) of the newly revised ASVCP QAS Guidelines. These guidelines are not intended to be all-inclusive; rather, they provide minimum guidelines for quality assurance and quality control for veterinary laboratory testing. It is hoped that these guidelines will provide a basis for laboratories to assess their current practices, determine areas for improvement, and guide continuing professional development and education efforts. ©2010 American Society for Veterinary Clinical Pathology.

  5. Laboratory Directed Research and Development 1998 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Pam Hughes; Sheila Bennett eds.

    1999-07-14

    The Laboratory's Directed Research and Development (LDRD) program encourages the advancement of science and the development of major new technical capabilities from which future research and development will grow. Through LDRD funding, Pacific Northwest continually replenishes its inventory of ideas that have the potential to address major national needs. The LDRD program has enabled the Laboratory to bring to bear its scientific and technical capabilities on all of DOE's missions, particularly in the arena of environmental problems. Many of the concepts related to environmental cleanup originally developed with LDRD funds are now receiving programmatic support from DOE, LDRD-funded work in atmospheric sciences is now being applied to DOE's Atmospheric Radiation Measurement Program. We also have used concepts initially explored through LDRD to develop several winning proposals in the Environmental Management Science Program. The success of our LDRD program is founded on good management practices that ensure funding is allocated and projects are conducted in compliance with DOE requirements. We thoroughly evaluate the LDRD proposals based on their scientific and technical merit, as well as their relevance to DOE's programmatic needs. After a proposal is funded, we assess progress annually using external peer reviews. This year, as in years past, the LDRD program has once again proven to be the major enabling vehicle for our staff to formulate new ideas, advance scientific capability, and develop potential applications for DOE's most significant challenges.

  6. Laboratory services series: the utilization of scientific glassblowing in a national research and development laboratory

    International Nuclear Information System (INIS)

    Farnham, R.M.; Poole, R.W.

    1976-04-01

    Glassblowing services at a national research and development laboratory provide unique equipment tailored for specific research efforts, small-scale process items for flowsheet demonstrations, and solutions for unusual technical problems such as glass-ceramic unions. Facilities, equipment, and personnel necessary for such services are described

  7. Argonne National Laboratory annual report of Laboratory Directed Research and Development Program Activities FY 2009.

    Energy Technology Data Exchange (ETDEWEB)

    Office of the Director

    2010-04-09

    I am pleased to submit Argonne National Laboratory's Annual Report on its Laboratory Directed Research and Development (LDRD) activities for fiscal year 2009. Fiscal year 2009 saw a heightened focus by DOE and the nation on the need to develop new sources of energy. Argonne scientists are investigating many different sources of energy, including nuclear, solar, and biofuels, as well as ways to store, use, and transmit energy more safely, cleanly, and efficiently. DOE selected Argonne as the site for two new Energy Frontier Research Centers (EFRCs) - the Institute for Atom-Efficient Chemical Transformations and the Center for Electrical Energy Storage - and funded two other EFRCs to which Argonne is a major partner. The award of at least two of the EFRCs can be directly linked to early LDRD-funded efforts. LDRD has historically seeded important programs and facilities at the lab. Two of these facilities, the Advanced Photon Source and the Center for Nanoscale Materials, are now vital contributors to today's LDRD Program. New and enhanced capabilities, many of which relied on LDRD in their early stages, now help the laboratory pursue its evolving strategic goals. LDRD has, since its inception, been an invaluable resource for positioning the Laboratory to anticipate, and thus be prepared to contribute to, the future science and technology needs of DOE and the nation. During times of change, LDRD becomes all the more vital for facilitating the necessary adjustments while maintaining and enhancing the capabilities of our staff and facilities. Although I am new to the role of Laboratory Director, my immediate prior service as Deputy Laboratory Director for Programs afforded me continuous involvement in the LDRD program and its management. Therefore, I can attest that Argonne's program adhered closely to the requirements of DOE Order 413.2b and associated guidelines governing LDRD. Our LDRD program management continually strives to be more efficient. In

  8. Argonne National Laboratory annual report of Laboratory Directed Research and Development Program Activities FY 2009

    International Nuclear Information System (INIS)

    2010-01-01

    I am pleased to submit Argonne National Laboratory's Annual Report on its Laboratory Directed Research and Development (LDRD) activities for fiscal year 2009. Fiscal year 2009 saw a heightened focus by DOE and the nation on the need to develop new sources of energy. Argonne scientists are investigating many different sources of energy, including nuclear, solar, and biofuels, as well as ways to store, use, and transmit energy more safely, cleanly, and efficiently. DOE selected Argonne as the site for two new Energy Frontier Research Centers (EFRCs) - the Institute for Atom-Efficient Chemical Transformations and the Center for Electrical Energy Storage - and funded two other EFRCs to which Argonne is a major partner. The award of at least two of the EFRCs can be directly linked to early LDRD-funded efforts. LDRD has historically seeded important programs and facilities at the lab. Two of these facilities, the Advanced Photon Source and the Center for Nanoscale Materials, are now vital contributors to today's LDRD Program. New and enhanced capabilities, many of which relied on LDRD in their early stages, now help the laboratory pursue its evolving strategic goals. LDRD has, since its inception, been an invaluable resource for positioning the Laboratory to anticipate, and thus be prepared to contribute to, the future science and technology needs of DOE and the nation. During times of change, LDRD becomes all the more vital for facilitating the necessary adjustments while maintaining and enhancing the capabilities of our staff and facilities. Although I am new to the role of Laboratory Director, my immediate prior service as Deputy Laboratory Director for Programs afforded me continuous involvement in the LDRD program and its management. Therefore, I can attest that Argonne's program adhered closely to the requirements of DOE Order 413.2b and associated guidelines governing LDRD. Our LDRD program management continually strives to be more efficient. In addition to

  9. Laboratory directed research and development annual report: 2005

    International Nuclear Information System (INIS)

    2006-01-01

    This report summarizes progress from the Laboratory Directed Research and Development (LDRD) program during fiscal year 2005 for Sandia National Laboratories. In addition to a programmatic and financial overview, the report includes progress reports from 410 individual R and D projects in 19 categories. The categories and subheadings are: Science, Technology and Engineering (Advanced Components and Certification Engineering; Advanced Manufacturing; Biotechnology; Chemical and Earth Sciences; Computational and Information Sciences; Electronics and Photonics; Engineering Sciences; Materials Science and Technology; Pulsed Power Sciences and High Energy Density Sciences; Science and Technology Strategic Objectives); Mission Technologies (Energy and Infrastructure Assurance; Homeland Security; Military Technologies and Applications; Nonproliferation and Assessments; Grand Challanges); and Corporate Objectives (Advanced Concepts; Seniors' Council; University Collaborations)

  10. Development status of post irradiation examination techniques at the JMTR Hot Laboratory

    International Nuclear Information System (INIS)

    Ohmi, M.; Ohsawa, K.; Nakagawa, T.; Umino, A.; Shimizu, M.; Satoh, H.; Oyamada, R.

    1992-01-01

    Hot laboratory at Oarai Research Establishment was founded to examine the objects mainly irradiated at JMTR (Japan Materials Testing Reactor) and has been operated since 1971. A wide variety of post-irradiation examinations (PIE) is available using the hot laboratory. Continuous efforts are made to develop new PIE techniques to accommodate the user's requirements. The following are main techniques recently developed in the hot laboratory; 1. Remote capsule assembly including remote weld of irradiated objects for reirradiation in JMTR. 2. Fracture toughness tests of reactor component materials. 3. Creep tests of heat resistance alloys in high temperature conditions. 4. Tests of irradiation assisted stress corrosion cracking (IASCC). 5. Examination techniques of miniaturized test specimens. This report describes an outline of the hot laboratory with main emphasis on the new PIE techniques. (author)

  11. Nuclear Plant Analyzer development at the Idaho National Engineering Laboratory

    International Nuclear Information System (INIS)

    Laats, E.T.

    1986-10-01

    The Nuclear Plant Analyzer (NPA) is a state-of-the-art safety analysis and engineering tool being used to address key nuclear power plant safety issues. Under the sponsorship of the US Nuclear Regulatory Commission (NRC), the NPA has been developed to integrate the NRC's computerized reactor behavior simulation codes such as RELAP5, TRAC-BWR and TRAC-PWR, with well-developed computer color graphics programs and large repositories of reactor design and experimental data. An important feature of the NPA is the capability to allow an analyst to redirect a RELAP5 or TRAC calculation as it progresses through its simulated scenario. The analyst can have the same power plant control capabilities as the operator of an actual plant. The NPA resides on the dual Control Data Corporation Cyber 176 mainframe computers at the Idaho National Engineering Laboratory and Cray-1S computers at the Los Alamos National Laboratory (LANL) and Kirtland Air Force Weapons Laboratory (KAFWL)

  12. Radioisotope research and development at Los Alamos National Laboratory

    International Nuclear Information System (INIS)

    Peterson, E.J.

    1993-01-01

    Throughout its fifty year history, Los Alamos National Laboratory has conducted research and development in the production, isolation, purification, and application of radioactive isotopes. Initially this work supported the weapons development mission of the Laboratory. Over the years the work has evolved to support basic and applied research in many diverse fields, including nuclear medicine, biomedical studies, materials science, environmental research and the physical sciences. In the early 1970s people in the Medical Radioisotope Research Program began irradiating targets at the Los Alamos Meson Physics Facility (LAMPF) to investigate the production and recovery of medically important radioisotopes. Since then spallation production using the high intensity beam at LAMPF has become a significant source of many important radioisotopes. Los Alamos posesses other facilities with isotope production capabilities. Examples are the Omega West Reactor (OWR) and the Van de Graaf Ion Beam Facility (IBF). Historically these facilities have had limited availability for radioisotope production, but recent developments portend a significant radioisotope production mission in the future

  13. Government-industry-uUniversity and rResearch lLaboratories cCoordination for new product development: Session 2. Government research laboratory perspective

    International Nuclear Information System (INIS)

    Kuzay, T.M.

    1997-01-01

    This talk is the second in an expanded series of presentations on the Government-Industry-University and Research Laboratories Coordination for new product development, which is a timely and important public policy issue. Such interactions have become particularly timely in light of the present decline in funding for research and development (R ampersand D) in the nation''s budget and in the private sector. These interactions, at least in principle, provide a means to maximize benefits for the greater good of the nation by pooling the diminishing resources. National laboratories, which traditionally interacted closely with the universities in educational training, now are able to also participate closely with industry in joint R ampersand D thanks to a number of public laws legislated since the early 80s. A review of the experiences with such interactions at Argonne National Laboratory, which exemplifies the national laboratories, shows that, despite differences in their traditions and the missions, the national laboratory-industry-university triangle can work together

  14. Development of guided inquiry-based laboratory worksheet on topic of heat of combustion

    Science.gov (United States)

    Sofiani, D.; Nurhayati; Sunarya, Y.; Suryatna, A.

    2018-03-01

    Chemistry curriculum reform shows an explicit shift from traditional approach to scientific inquiry. This study aims to develop a guided inquiry-based laboratory worksheet on topic of heat of combustion. Implementation of this topic in high school laboratory is new because previously some teachers only focused the experiment on determining the heat of neutralization. The method used in this study was development research consisted of three stages: define, design, and develop. In the define stage, curriculum analysis and material analysis were performed. In the design stage, laboratory optimization and product preparation were conducted. In the development stage, the product was evaluated by the experts and tested to a total of 20 eleventh-grade students. The instruments used in this study were assessment sheet and students’ response questionnaire. The assessment results showed that the guided inquiry-based laboratory worksheet has very good quality based on the aspects of content, linguistic, and graphics. The students reacted positively to the use of this guided inquiry-based worksheet as demonstrated by the results from questionnaire. The implications of this study is the laboratory activity should be directed to development of scientific inquiry skills in order to enhance students’ competences as well as the quality of science education.

  15. Newly graduated nurses' use of knowledge sources

    DEFF Research Database (Denmark)

    Voldbjerg, Siri Lygum; Grønkjaer, Mette; Sørensen, Erik Elgaard

    2016-01-01

    AIM: To advance evidence on newly graduated nurses' use of knowledge sources. BACKGROUND: Clinical decisions need to be evidence-based and understanding the knowledge sources that newly graduated nurses use will inform both education and practice. Qualitative studies on newly graduated nurses' use...... underscoring progression in knowledge use and perception of competence and confidence among newly graduated nurses. CONCLUSION: The transition phase, feeling of confidence and ability to use critical thinking and reflection, has a great impact on knowledge sources incorporated in clinical decisions....... The synthesis accentuates that for use of newly graduated nurses' qualifications and skills in evidence-based practice, clinical practice needs to provide a supportive environment which nurtures critical thinking and questions and articulates use of multiple knowledge sources....

  16. Laboratory directed research and development FY91

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, S.E.; Hedman, I.; Kirvel, R.D.; McGregor, C.K. (eds.)

    1991-01-01

    This review of research programs at Lawrence Livermore National Laboratory is composed of individual papers on various subjects. Broad topics of interest are: chemistry and materials science, computation, earth sciences, engineering, nuclear physics, and physics, and biology. Director's initiatives include the development of a transgenic mouse, accelerator mass spectrometry, high-energy physics detectors, massive parallel computing, astronomical telescopes, the Kuwaiti oil fires and a compact torus accelerator. (GHH)

  17. Being a team leader: newly registered nurses relate their experiences.

    Science.gov (United States)

    Ekström, Louise; Idvall, Ewa

    2015-01-01

    This paper presents a study that explores how newly qualified registered nurses experience their leadership role in the ward-based nursing care team. A nurse's clinical leadership affects the quality of care provided. Newly qualified nurses experience difficulties during the transition period from student to qualified professional and find it challenging to lead nursing care. Twelve nurses were interviewed and the transcribed texts analysed using qualitative content analysis to assess both manifest and latent content. Five themes were identified: feeling stranded; forming well-functioning teams; learning to lead; having the courage, strength, and desire to lead; and ensuring appropriate care. The findings indicate that many factors limit nurses' leadership but some circumstances are supportive. The leadership prerequisites for newly registered nurses need to improve, emphasizing different ways to create a supportive atmosphere that promotes professional development and job satisfaction. To increase nurse retention and promote quality of care, nurse managers need to clarify expectations and guide and support newly qualified nurses in a planned way. © 2013 John Wiley & Sons Ltd.

  18. CHARACTERIZATION OF CURRENTLY GENERATED TRANUSRANIC WASTE AT THE LOS ALAMOS NATIONAL LABORATORY'S PLUTONIUM PRODUCTION FACILITY

    International Nuclear Information System (INIS)

    Dodge, Robert L.; Montoya, Andy M.

    2003-01-01

    By the time the Waste Isolation Pilot Plant (WIPP) completes its Disposal Phase in FY 2034, the Department of Energy (DOE) will have disposed of approximately 109,378 cubic meters (m3) of Transuranic (TRU) waste in WIPP (1). If DOE adheres to its 2005 Pollution Prevention Goal of generating less than 141m3/yr of TRU waste, approximately 5000 m3 (4%) of that TRU waste will be newly generated (2). Because of the overwhelming majority (96%) of TRU waste destined for disposal at WIPP is legacy waste, the characterization and certification requirements were developed to resolve those issues related to legacy waste. Like many other DOE facilities Los Alamos National Laboratory (LANL) has a large volume (9,010m3) of legacy Transuranic Waste in storage (3). Unlike most DOE facilities LANL will generate approximately 140m3 of newly generated TRU waste each year3. LANL's certification program was established to meet the WIPP requirements for legacy waste and does not take advantage of the fundamental differences in waste knowledge between newly generated and legacy TRU waste

  19. Gamification of the Laboratory Experience to Encourage Student Engagement

    Directory of Open Access Journals (Sweden)

    Kevin Drace

    2013-08-01

    Full Text Available The American Society for Microbiology (ASM Task Force on Curriculum Guidelines for Undergraduate Microbiology Students published recommendations for introductory microbiology courses that suggest teaching specific skill sets in the laboratory beyond just fundamental knowledge and concepts of microbiology (6; however, students can sometimes view a skills-based laboratory experience as a task list of unrelated assignments to complete for a grade. Therefore, providing explicit connections throughout the lecture and laboratory exercises is critical for a truly integrated learning experience. Several pedagogical techniques can provide a coherent framework throughout a course. For example, case-based studies can connect lecture with laboratory skills and increase student engagement by applying newly developed knowledge and skills to tackle real-world simulations (2, 3. One reason that case-based studies succeed is that they can provide intrinsic motivations and an alternate purpose for students to engage with the material. A more recent trend in pedagogy involves using game design elements to increase student engagement and motivation. Gamification is the application of game design (accruing points or badges, reaching significant levels of accomplishment, or other reward elements in a non-game context to motivate or influence participation (1, 5. A natural extension of both of these methods is to gamify a case-based approach where a fictional scenario is presented for students to role-play as scientists using their developed skills to solve a complex problem. The typical microbiology laboratory, as described by the ASM Task Force, can easily incorporate game design elements without extensive modification of the exercises themselves. Instead, gamification involves structuring the lab in a way that gives the course a coherent and unified purpose. This ultimately allows the student to see how the principles and concepts of lecture and laboratory connect

  20. Laboratory Directed Research and Development FY2008 Annual Report

    International Nuclear Information System (INIS)

    Kammeraad, J.E.; Jackson, K.J.; Sketchley, J.A.; Kotta, P.R.

    2009-01-01

    The Laboratory Directed Research and Development (LDRD) Program, authorized by Congress in 1991 and administered by the Institutional Science and Technology Office at Lawrence Livermore, is our primary means for pursuing innovative, long-term, high-risk, and potentially high-payoff research that supports the full spectrum of national security interests encompassed by the missions of the Laboratory, the Department of Energy, and National Nuclear Security Administration. The accomplishments described in this annual report demonstrate the strong alignment of the LDRD portfolio with these missions and contribute to the Laboratory's success in meeting its goals. The LDRD budget of $91.5 million for fiscal year 2008 sponsored 176 projects. These projects were selected through an extensive peer-review process to ensure the highest scientific quality and mission relevance. Each year, the number of deserving proposals far exceeds the funding available, making the selection a tough one indeed. Our ongoing investments in LDRD have reaped long-term rewards for the Laboratory and the nation. Many Laboratory programs trace their roots to research thrusts that began several years ago under LDRD sponsorship. In addition, many LDRD projects contribute to more than one mission area, leveraging the Laboratory's multidisciplinary team approach to science and technology. Safeguarding the nation from terrorist activity and the proliferation of weapons of mass destruction will be an enduring mission of this Laboratory, for which LDRD will continue to play a vital role. The LDRD Program is a success story. Our projects continue to win national recognition for excellence through prestigious awards, papers published in peer-reviewed journals, and patents granted. With its reputation for sponsoring innovative projects, the LDRD Program is also a major vehicle for attracting and retaining the best and the brightest technical staff and for establishing collaborations with universities

  1. REMOTE RF LABORATORY REQUIREMENTS: Engineers’ and Technicians’ Perspective

    Directory of Open Access Journals (Sweden)

    Nergiz Ercil CAGILTAY

    2007-10-01

    Full Text Available ABSTRACT This study aims to find out requirements and needs to be fulfilled in developing remote Radio Frequency (RF laboratory. Remote laboratories are newly emerging solutions for better supporting of e-learning platforms and for increasing their efficiency and effectiveness in technical education. By this way, modern universities aim to provide lifelong learning environments to extend their education for a wider area and support learners anytime and anywhere when they need help. However, as far as the authors concern, there is no study investigating the requirements and needs of remote laboratories in that particular field in the literature. This study is based on electrical engineers’ and technicians’ perspectives on the requirements of a remote laboratory in RF domain. Its scope covers investigation of the participants’ perceptions toward computer mediated communication and it attempts to answer the questions: which studying strategies are preferred by the learners and what kind of RF laboratory content should be provided. The analysis of the results showed that, geographic independence, finding quickly the elements of past communication and temporal independence are declared as the most important advantages of computer-mediated communication. However, reading significant amount of information is a problem of these environments. In the context of how to show the content, respondents want to see shorter text on the screen. Therefore the instructions should include little amount of text and must be supported with figures and interactive elements. The instructional materials developed for such learner groups should support both linear and non-linear instructions. While analyzing the content to be provided, we have seen that, most of the participants do not have access to high level equipments and traditional experiments are considered as the necessary ones for both engineers and technicians.

  2. Developments of Spent Nuclear Fuel Pyroprocessing Technology at Idaho National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Michael F. Simpson

    2012-03-01

    This paper summarizes research in used fuel pyroprocessing that has been published by Idaho National Laboratory over the last decade. It includes work done both on treatment of Experimental Breeder Reactor-II and development of advanced technology for potential scale-up and commercialization. Collaborations with universities and other laboratories is included in the cited work.

  3. Development of ODL in a Newly Industrialized Country according to Face-to-Face Contact, ICT, and E-Readiness

    Directory of Open Access Journals (Sweden)

    J. Marinda van Zyl

    2013-03-01

    Full Text Available A large number of unqualified and under-qualified in-service teachers are holding back socio-economical development in South Africa, a newly industrialized country. Open and distance learning (ODL provides an innovative strategy and praxis for developing and newly industrialized countries to reach their educational and socio-economical objectives through professional development and training. In order to examine factors which affect the success of ODL offered by the North-West University in South Africa, a qualitative and quantitative research approach is used. Factors examined include face-to-face classroom contact, the implementation and use of ICTs, and e-readiness. The relationships between these factors are also discussed. A questionnaire was administered to 87 teacher-students in four Advanced Certificate in Education (ACE programs to collect quantitative data regarding aspects of their classes and the e-readiness of students. This data was qualitatively elaborated upon by three semi-structured, open-ended focus-group interviews. Besides descriptive statistics, Spearman’s rank-order correlations (r were determined between variables pertaining to negative feelings towards face-to-face classroom contact, ODL as students’ choice of delivery mode, and students’ positive attitude towards information and communication technology (ICT. Combined quantitative and qualitative findings were used to evaluate the effectiveness of contact classes as well as the e-readiness of students towards the attainment of ODL development Phase D. This phase refers to UNESCO’s description of ICT implementation, integration, and use. Relationships (Spearman’s rank-order correlations between ODL, as teacher-students’ choice of educational delivery mode, and aspects of their e-readiness suggest that the e-readiness of teacher-students is implicit to their choice of ODL as educational delivery mode for professional development.

  4. Erosion of newly developed CFCs and Be under disruption heat loads

    Science.gov (United States)

    Nakamura, K.; Akiba, M.; Araki, M.; Dairaku, M.; Sato, K.; Suzuki, S.; Yokoyama, K.; Linke, J.; Duwe, R.; Bolt, H.; Roedig, M.

    1996-10-01

    An evaluation of the erosion under disruption heat loads is very important to the lifetime prediction of divertor armour tiles of next fusion devices such as ITER. In particular, erosion data on CFCs (carbon fiber reinforced composites) and beryllium (Be) as the armour materials is urgently required in the ITER design. For CFCs, high heat flux experiments on the newly developed CFCs with high thermal conductivity have been performed under the heat flux of around 800-2000 MW/m 2 and the pulse length of 2-5 ms in JAERI electron beam irradiation systems (JEBIS). As a result, the weight losses of B 4C doped CFCs after heating were almost same to those of the non doped CFC up to 5 wt% boron content. For Be, we have carried out our first disruption experiments on S65/C grade Be specimens in the Juelich divertor test facility in hot cells (JUDITH) facility as a frame work of the J—EU collaboration. The heating conditions were heat loads of 1250-5000 MW/m 2 for 2-8 ms, and the heated area was 3 × 3 mm 2. As a result, the protuberances of the heated area of Be were observed under the lower heat flux.

  5. Erosion of newly developed CFCs and Be under disruption heat loads

    International Nuclear Information System (INIS)

    Nakamura, K.; Duwe, R.; Bolt, H.; Roedig, M.

    1996-01-01

    An evaluation of the erosion under disruption heat loads is very important to the lifetime prediction of divertor armour tiles of next fusion devices such as ITER. In particular, erosion data on CFCs (carbon fiber reinforced composites) and beryllium (Be) as the armour materials is urgently required in the ITER design. For CFCs, high heat flux experiments on the newly developed CFCs with high thermal conductivity have been performed under the heat flux of around 800-2000 MW/m 2 and the pulse length of 2-5 ms in JAERI electron beam irradiation systems (JEBIS). As a result, the weight losses of B 4 C doped CFCs after heating were almost same to those of the non doped CFC up to 5 wt% boron content. For Be, we have carried out our first disruption experiments on S65/C grade Be specimens in the Juelich divertor test facility in hot cells (JUDITH) facility as a frame work of the J-EU collaboration. The heating conditions were heat loads of 1250-5000 MW/m 2 for 2-8 ms, and the heated area was 3 x 3 mm 2 . As a result, the protuberances of the heated area of Be were observed under the lower heat flux. (orig.)

  6. Weldability aspects of a newly developed duplex stainless steel LDX 2101

    Energy Technology Data Exchange (ETDEWEB)

    Westin, E.M. [Avesta Research Centre, Avesta (Sweden). Outokumpu Stainless; Brolund, B. [SSAB Tunnplat, Borlaenge (Sweden); Hertzman, S. [Outokumpu Stainless Research Foundation, Stockholm (Sweden)

    2008-06-15

    Duplex grades have, due to balanced chemical compositions of both filler and base metals, a weldability that allows for successful welding using a majority of the technically relevant techniques of today. In order to fulfil the performance requirements several aspects must be considered. In the heat affected zone (HAZ) the austenite reformation must be reasonably high and in the weld metal the microstructure must be stable so that e.g. high productivity welding and multi-pass welding are possible, without precipitation of detrimental phases in previous passes. This paper addresses the effect of alloying elements and thermal cycles on phase balance in the high temperature HAZ (HTHAZ) of the newly developed lean duplex grade LDX 2101 (EN 1.4162, UNS S32101). Bead-on-plate welds and simulated weld structures have been produced and investigated using metallography, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The results are analysed using the thermodynamic database Thermo-Calc and a model for phase transformation based on a paraequilibrium assumption for ferrite-austenite transformation. In the temperature region outside the paraequilibrium domain, growth controlled by diffusion of substitutional elements was considered. The analysis follows a model by Cahn regarding grain boundary nucleated growth and the Hillert-Engberg model on kinetics of spherical and planar growth. (orig.)

  7. 2016 Fermilab Laboratory Directed Research & Development Program Plan

    Energy Technology Data Exchange (ETDEWEB)

    Wester, W. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

    2016-05-25

    Fermilab is executing Laboratory Directed Research and Development (LDRD) as outlined by order DOE O 413.2B in order to enhance and realize the mission of the laboratory in a manner that also supports the laboratory’s strategic objectives and the mission of the Department of Energy. LDRD funds enable scientific creativity, allow for exploration of “high risk, high payoff” research, and allow for the demonstration of new ideas, technical concepts, and devices. LDRD also has an objective of maintaining and enhancing the scientific and technical vitality of Fermilab. LDRD is able to fund employee-initiated proposals that address the current strategic objectives and better position Fermilab for future mission needs. The request for such funds is made in consideration of the investment needs, affordability, and directives from DOE and Congress. Review procedures of the proposals will insure that those proposals which most address the strategic goals of the DOE and the Laboratory or which best position Fermilab for the future will be recommended to the Laboratory Director who has responsibility for approval. The execution of each approved project will be the responsibility of the Principal Investigator, PI, who will follow existing Laboratory guidelines to ensure compliance with safety, environmental, and quality assurance practices. A Laboratory Director-appointed LDRD Coordinator will work with Committees, Laboratory Management, other Fermilab Staff, and the PI’s to oversee the implementation of policies and procedures of LDRD and provide the management and execution of this Annual Program Plan. FY16 represents third fiscal year in which LDRD has existed at Fermilab. The number of preliminary proposals (117) submitted in response to the LDRD Call for Proposals indicates very strong interest of the program within the Fermilab community. The first two Calls have resulted in thirteen active LDRD projects – and it is expected that between five and seven new

  8. Development of a building performance laboratory for South Africa

    CSIR Research Space (South Africa)

    Parsons, S

    2009-05-01

    Full Text Available The CSIR Building Science and Technology Competence area is currently in the process of establishing a Building Performance Laboratory (BPL). The BPL is aimed at becoming a centre at which the knowledge generation and technology development...

  9. LABORATORY DIRECTED RESEARCH AND DEVELOPMENT ANNUAL REPORT TO THE DOE - DECEMBER 2001

    International Nuclear Information System (INIS)

    FOX, K.J.

    2001-01-01

    Brookhaven National (BNL) Laboratory is a multidisciplinary laboratory that carries out basic and applied research in the physical, biomedical, and environmental sciences, and in selected energy technologies. It is managed by Brookhaven Science Associates, LLC, under contract with the U. S. Department of Energy. BNL's total annual budget has averaged about$450 million. There are about 3,000 employees, and another 4,500 guest scientists and students who come each year to use the Laboratory's facilities and work with the staff. The BNL Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) annually in March, as required by DOE Order 4 13.2, ''Laboratory Directed Research and Development,'' March 5, 1997, and the LDRD Annual Report guidance, updated February 12, 1999. The LDRD Program obtains its funds through the Laboratory overhead pool and operates under the authority of DOE Order 4 13.2. The goals and objectives of BNL's LDRD Program can be inferred from the Program's stated purposes. These are to (1) encourage and support the development of new ideas and technology, (2) promote the early exploration and exploitation of creative and innovative concepts, and (3) develop new ''fundable'' R and D projects and programs. The emphasis is clearly articulated by BNL to be on supporting exploratory research ''which could lead to new programs, projects, and directions'' for the Laboratory. As one of the premier scientific laboratories of the DOE, BNL must continuously foster groundbreaking scientific research. At Brookhaven National Laboratory one such method is through its LDRD Program. This discretionary research and development tool is critical in maintaining the scientific excellence and long-term vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community and foster new science and technology ideas, which becomes a major factor in achieving and maintaining staff excellence

  10. GELCASTING: From laboratory development toward industrial production

    Energy Technology Data Exchange (ETDEWEB)

    Omatete, O.O.; Janney, M.A.; Nunn, S.D.

    1995-07-01

    Gelcasting, a ceramic forming process, was developed to overcome some of the limitations of other complex-shape forming techniques such as injection molding and slip casting. In gelcasting, a concentrated slurry of ceramic powder in a solution of organic monomers is poured into a mold and then polymerized in-situ to form a green body in the shape of the mold cavity. Thus, it is a combination of polymer chemistry with slip processing and represents minimal departure from standard ceramic processing. The simplicity of the process has attracted industrial partners and by collaboration between them and the developers, the process is being advanced from the laboratory toward industrial production.

  11. LABORATORY DIRECTED RESEARCH AND DEVELOPMENT ANNUAL REPORT TO THE DEPARTMENT OF ENERGY - DECEMBER 2006

    Energy Technology Data Exchange (ETDEWEB)

    FOX, K.J.

    2006-12-31

    Brookhaven National Laboratory (BNL) is a multidisciplinary laboratory that carries out basic and applied research in the physical, biomedical, and environmental sciences, and in selected energy technologies. It is managed by Brookhaven Science Associates, LLC, (BSA) under contract with the U. S. Department of Energy (DOE). BNL's total annual budget has averaged about $460 million. There are about 2,500 employees, and another 4,500 guest scientists and students who come each year to use the Laboratory's facilities and work with the staff. The BNL Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) annually in March, as required by DOE Order 413.2B, ''Laboratory Directed Research and Development,'' April 19, 2006, and the Roles, Responsibilities, and Guidelines for Laboratory Directed Research and Development at the Department of Energy National Nuclear Security Administration Laboratories dated June 13, 2006. In accordance this is our Annual Report in which we describe the Purpose, Approach, Technical Progress and Results, and Specific Accomplishments of all LDRD projects that received funding during Fiscal Year 2006.

  12. Characterization of BEGe detectors in the HADES underground laboratory

    Science.gov (United States)

    Andreotti, Erica; Gerda Collaboration

    2013-08-01

    This paper describes the characterization of newly produced Broad Energy Germanium (BEGe) detectors, enriched in the isotope 76Ge. These detectors have been produced in the frame of the GERDA experiment. The aim of the characterization campaign consists in the determination of all the important operational parameters (active volume, dead layer thickness and uniformity, energy resolution, detector stability in time, quality of pulse shape discrimination). A protocol test procedure and devoted set-ups, partially automated, have been developed in view of the large number (∼ 25) of BEGe's detectors to be tested. The characterization is carried out in the HADES underground laboratory, located 225 m below ground (∼ 500 m water equivalent) in Mol, Belgium.

  13. Characterization of BEGe detectors in the HADES underground laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Andreotti, Erica, E-mail: Erica.ANDREOTTI@ec.europa.eu [Joint Research Centre, Institute for Reference Materials and Measurements, Retieseweg 111, B-2440 Geel (Belgium)

    2013-08-01

    This paper describes the characterization of newly produced Broad Energy Germanium (BEGe) detectors, enriched in the isotope {sup 76}Ge. These detectors have been produced in the frame of the GERDA experiment. The aim of the characterization campaign consists in the determination of all the important operational parameters (active volume, dead layer thickness and uniformity, energy resolution, detector stability in time, quality of pulse shape discrimination). A protocol test procedure and devoted set-ups, partially automated, have been developed in view of the large number (∼25) of BEGe's detectors to be tested. The characterization is carried out in the HADES underground laboratory, located 225 m below ground (∼500m water equivalent) in Mol, Belgium.

  14. Pellet fueling development at Oak Ridge National Laboratory

    International Nuclear Information System (INIS)

    Foster, C.A.; Milora, S.L.; Schuresko, D.D.; Combs, S.K.; Lunsford, R.V.

    1982-01-01

    A pellet injector development program has been under way at the Oak Ridge National Laboratory (ORNL) since 1976 with the goals of developing D 2 , T 2 pellet fuel injectors capable of reliable repetitive fueling of reactors and of continued experimentation on contemporary plasma devices. The development has focused primarily on two types of injectors that show promise. One of these injectors is the centrifuge-type injector, which accelerates pellets in a high speed rotating track. The other is the gas or pneumatic gun, which accelerates pellets in a gun barrel using compressed helium of H 2 gas

  15. Laboratory automation of high-quality and efficient ligand-binding assays for biotherapeutic drug development.

    Science.gov (United States)

    Wang, Jin; Patel, Vimal; Burns, Daniel; Laycock, John; Pandya, Kinnari; Tsoi, Jennifer; DeSilva, Binodh; Ma, Mark; Lee, Jean

    2013-07-01

    Regulated bioanalytical laboratories that run ligand-binding assays in support of biotherapeutics development face ever-increasing demand to support more projects with increased efficiency. Laboratory automation is a tool that has the potential to improve both quality and efficiency in a bioanalytical laboratory. The success of laboratory automation requires thoughtful evaluation of program needs and fit-for-purpose strategies, followed by pragmatic implementation plans and continuous user support. In this article, we present the development of fit-for-purpose automation of total walk-away and flexible modular modes. We shared the sustaining experience of vendor collaboration and team work to educate, promote and track the use of automation. The implementation of laboratory automation improves assay performance, data quality, process efficiency and method transfer to CRO in a regulated bioanalytical laboratory environment.

  16. Parsing multiple processes of high temperature impacts on corn/soybean yield using a newly developed CLM-APSIM modeling framework

    Science.gov (United States)

    Peng, B.; Guan, K.; Chen, M.

    2016-12-01

    Future agricultural production faces a grand challenge of higher temperature under climate change. There are multiple physiological or metabolic processes of how high temperature affects crop yield. Specifically, we consider the following major processes: (1) direct temperature effects on photosynthesis and respiration; (2) speed-up growth rate and the shortening of growing season; (3) heat stress during reproductive stage (flowering and grain-filling); (4) high-temperature induced increase of atmospheric water demands. In this work, we use a newly developed modeling framework (CLM-APSIM) to simulate the corn and soybean growth and explicitly parse the above four processes. By combining the strength of CLM in modeling surface biophysical (e.g., hydrology and energy balance) and biogeochemical (e.g., photosynthesis and carbon-nitrogen interactions), as well as that of APSIM in modeling crop phenology and reproductive stress, the newly developed CLM-APSIM modeling framework enables us to diagnose the impacts of high temperature stress through different processes at various crop phenology stages. Ground measurements from the advanced SoyFACE facility at University of Illinois is used here to calibrate, validate, and improve the CLM-APSIM modeling framework at the site level. We finally use the CLM-APSIM modeling framework to project crop yield for the whole US Corn Belt under different climate scenarios.

  17. UTRaLab – Urban Traffic Research Laboratory

    Directory of Open Access Journals (Sweden)

    Karsten Kozempel

    2017-08-01

    Full Text Available The Urban Traffic Research Laboratory (UTRaLab is a research and test track for traffic detection methods and sensors. It is located at the Ernst-Ruska-Ufer, in the southeast of the city of Berlin (Germany. The UTRaLab covers 1 km of a highly-frequented urban road and is connected to a motorway. It is equipped with two gantries with distance of 850 m in between and has several outstations for data collection. The gantries contain many different traffic sensors like inductive loops, cameras, lasers or wireless sensors for traffic data acquisition. Additionally a weather station records environmental data. The UTRaLab’s main purposes are the data collection of traffic data on the one hand and testing newly developed sensors on the other hand.

  18. Use of newly developed standardized form for interpretation of high-resolution CT in screening for pneumoconiosis

    International Nuclear Information System (INIS)

    Julien, P.J.; Sider, L.; Silverman, J.M.; Dahlgren, J.; Harber, P.; Bunn, W.

    1991-01-01

    This paper reports that although the International Labour Office (ILO) standard for interpretation of the posteroanterior chest radiograph has been available for 10 years, there has been no attempt to standardize the high-resolution CT (HRTC) readings for screening of pneumoconiosis. An integrated respirator surveillance program for 87 workers exposed to inorganic dust was conducted. This program consisted of a detailed occupational exposure history, physical symptoms and signs, spirometry, chest radiography, and HRCT. Two groups of workers with known exposure were studied with HRCT. Group 1 had normal spirometry results and chest radiographs, and group 2 had abnormalities at spirometry or on chest radiographs. The HRCT scans were read independently of the clinical findings and chest radiographs. The HRCT scans were interpreted by using an ILO-based standard form developed by the authors for this project. With the newly developed HRCT form, individual descriptive abnormality localized severity, and overall rating systems have been developed and compared for inter- and intraobserver consistency

  19. Human capital gaps in vaccine development: an issue for global vaccine development and global health.

    Science.gov (United States)

    Cawein, Andrea; Emini, Emilio; Watson, Michael; Dailey, Joanna; Donnelly, John; Tresnan, Dina; Evans, Tom; Plotkin, Stanley; Gruber, William

    2017-05-01

    Despite the success of vaccines in reducing the morbidity and mortality associated with infectious diseases, many infectious diseases, both newly emerging and well known, lack vaccines. The global capability for beginning-to-end vaccine development has become limited, primarily owing to a scarcity of human capital necessary to guide the development of novel vaccines from the laboratory to the marketplace. Here, we identify and discuss the gaps in human capital necessary for robust vaccine development and make recommendations to begin to address these deficiencies. © 2017 New York Academy of Sciences.

  20. Laboratory Directed Research and Development FY2008 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Kammeraad, J E; Jackson, K J; Sketchley, J A; Kotta, P R

    2009-03-24

    The Laboratory Directed Research and Development (LDRD) Program, authorized by Congress in 1991 and administered by the Institutional Science and Technology Office at Lawrence Livermore, is our primary means for pursuing innovative, long-term, high-risk, and potentially high-payoff research that supports the full spectrum of national security interests encompassed by the missions of the Laboratory, the Department of Energy, and National Nuclear Security Administration. The accomplishments described in this annual report demonstrate the strong alignment of the LDRD portfolio with these missions and contribute to the Laboratory's success in meeting its goals. The LDRD budget of $91.5 million for fiscal year 2008 sponsored 176 projects. These projects were selected through an extensive peer-review process to ensure the highest scientific quality and mission relevance. Each year, the number of deserving proposals far exceeds the funding available, making the selection a tough one indeed. Our ongoing investments in LDRD have reaped long-term rewards for the Laboratory and the nation. Many Laboratory programs trace their roots to research thrusts that began several years ago under LDRD sponsorship. In addition, many LDRD projects contribute to more than one mission area, leveraging the Laboratory's multidisciplinary team approach to science and technology. Safeguarding the nation from terrorist activity and the proliferation of weapons of mass destruction will be an enduring mission of this Laboratory, for which LDRD will continue to play a vital role. The LDRD Program is a success story. Our projects continue to win national recognition for excellence through prestigious awards, papers published in peer-reviewed journals, and patents granted. With its reputation for sponsoring innovative projects, the LDRD Program is also a major vehicle for attracting and retaining the best and the brightest technical staff and for establishing collaborations with

  1. Developing a Novel USB-PLC Controller for a Mechatronics Cloud Laboratory

    Directory of Open Access Journals (Sweden)

    Wen-Jye Shyr

    2013-04-01

    Full Text Available This study proposes the development and implementation of a novel Universal Serial Bus (USB-Programmable Logic Controller (PLC, called a USB-PLC controller, for a mechatronics cloud laboratory. The aim of a mechatronics cloud laboratory is to provide state of the art research quality equipment to students, allowing them to conduct hands-on experiments via the Internet. One objective of the cloud laboratory is to not only provide equipment for conducting set experiments, but also to provide a means for students to access research equipment in order to conduct individual research experiments. The proposed controller for these cloud laboratory experiments has been chosen in order to expose the students to as many different engineering and technology disciplines as possible.

  2. The improvement of screw compressor performance using a newly developed rotor profile

    International Nuclear Information System (INIS)

    Kishi, Takayuki; Nishio, Toshio; Matsui, Akira; Ino, Nobumi

    1994-01-01

    An oil-compression phenomenon occurs at two portions of a conventional oil injected screw compressor that degrades the isothermal efficiency of the screw compressor. Hence a new screw rotor profile and lubricant have been developed in order to avoid the above oil-compression phenomena. Mycom and Fermi National Accelerator Laboratory have measured the performance of a new Mycom compound type screw compressor 2016C using the new profile rotors and the new lubricant. In the experiments, a 33% enhancement rate in the isothermal efficiency of the new screw compressor installed in Fermilab was achieved

  3. Verification of gamma knife based fractionated radiosurgery with newly developed head-thorax phantom

    International Nuclear Information System (INIS)

    Bisht, Raj Kishor; Kale, Shashank Sharad; Natanasabapathi, Gopishankar; Singh, Manmohan Jit; Agarwal, Deepak; Garg, Ajay; Rath, Goura Kishore; Julka, Pramod Kumar; Kumar, Pratik; Thulkar, Sanjay; Sharma, Bhawani Shankar

    2016-01-01

    Objective: Purpose of the study is to verify the Gamma Knife Extend™ system (ES) based fractionated stereotactic radiosurgery with newly developed head-thorax phantom. Methods: Phantoms are extensively used to measure radiation dose and verify treatment plan in radiotherapy. A human upper body shaped phantom with thorax was designed to simulate fractionated stereotactic radiosurgery using Extend™ system of Gamma Knife. The central component of the phantom aids in performing radiological precision test, dosimetric evaluation and treatment verification. A hollow right circular cylindrical space of diameter 7.0 cm was created at the centre of this component to place various dosimetric devices using suitable adaptors. The phantom is made of poly methyl methacrylate (PMMA), a transparent thermoplastic material. Two sets of disk assemblies were designed to place dosimetric films in (1) horizontal (xy) and (2) vertical (xz) planes. Specific cylindrical adaptors were designed to place thimble ionization chamber inside phantom for point dose recording along xz axis. EBT3 Gafchromic films were used to analyze and map radiation field. The focal precision test was performed using 4 mm collimator shot in phantom to check radiological accuracy of treatment. The phantom head position within the Extend™ frame was estimated using encoded aperture measurement of repositioning check tool (RCT). For treatment verification, the phantom with inserts for film and ion chamber was scanned in reference treatment position using X-ray computed tomography (CT) machine and acquired stereotactic images were transferred into Leksell Gammaplan (LGP). A patient treatment plan with hypo-fractionated regimen was delivered and identical fractions were compared using EBT3 films and in-house MATLAB codes. Results: RCT measurement showed an overall positional accuracy of 0.265 mm (range 0.223 mm–0.343 mm). Gamma index analysis across fractions exhibited close agreement between LGP and film

  4. Monolithic circuit development for RHIC at Oak Ridge National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Alley, G.T.; Britton, C.L. Jr.; Kennedy, E.J.; Newport, D.F.; Wintenberg, A.L.; Young, G.R. [Oak Ridge National Laboratory, TN (United States)

    1991-12-31

    The work performed for RHIC at Oak Ridge National Laboratory during FY 91 is presented in this paper. The work includes preamplifier, analog memory, and analog-digital converter development for Dimuon Pad Readout, and evaluation and development of preamplifier-shapers for silicon strip readout. The approaches for implementation are considered as well as measured data for the various circuits that have been developed.

  5. 78 FR 66992 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Science.gov (United States)

    2013-11-07

    ... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical... the panels of the Joint Biomedical Laboratory Research and Development and Clinical Science Research..., behavioral, and clinical science research. The panel meetings will be open to the public for approximately...

  6. 75 FR 57833 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Science.gov (United States)

    2010-09-22

    ... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical... the panels of the Joint Biomedical Laboratory Research and Development and Clinical Science Research... Crowne Plaza Clinical Research Program December 3, 2010 *VA Central Office Mental Hlth & Behav Sci-A...

  7. 78 FR 22622 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Science.gov (United States)

    2013-04-16

    ... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical... the panels of the Joint Biomedical Laboratory Research and Development and Clinical Science Research... biomedical, behavioral and clinical science research. The panel meetings will be open to the public for...

  8. 77 FR 64598 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Science.gov (United States)

    2012-10-22

    ... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical...) that the panels of the Joint Biomedical Laboratory Research and Development and Clinical Science... areas of biomedical, behavioral and clinical science research. The panel meetings will be open to the...

  9. Upgrades of Hanford Engineering Development Laboratory hot cell facilities

    International Nuclear Information System (INIS)

    Daubert, R.L.; DesChane, D.J.

    1987-01-01

    The Hanford Engineering Development Laboratory operates the 327 Postirradiation Testing Laboratory (PITL) and the 324 Shielded Materials Facility (SMF). These hot cell facilities provide diverse capabilities for the postirradiation examination and testing of irradiated reactor fuels and materials. The primary function of these facilities is to determine failure mechanisms and effects of irradiation on physical and mechanical properties of reactor components. The purpose of this paper is to review major equipment and facility upgrades that enhance customer satisfaction and broaden the engineering capabilities for more diversified programs. These facility and system upgrades are providing higher quality remote nondestructive and destructive examination services with increased productivity, operator comfort, and customer satisfaction

  10. Laboratory Works Designed for Developing Student Motivation in Computer Architecture

    Directory of Open Access Journals (Sweden)

    Petre Ogrutan

    2017-02-01

    Full Text Available In light of the current difficulties related to maintaining the students’ interest and to stimulate their motivation for learning, the authors have developed a range of new laboratory exercises intended for first-year students in Computer Science as well as for engineering students after completion of at least one course in computers. The educational goal of the herein proposed laboratory exercises is to enhance the students’ motivation and creative thinking by organizing a relaxed yet competitive learning environment. The authors have developed a device including LEDs and switches, which is connected to a computer. By using assembly language, commands can be issued to flash several LEDs and read the states of the switches. The effectiveness of this idea was confirmed by a statistical study.

  11. LABORATORY DIRECTED RESEARCH AND DEVELOPMENT ANNUAL REPORT TO THE DOE - DECEMBER 2001.

    Energy Technology Data Exchange (ETDEWEB)

    FOX,K.J.

    2001-12-01

    Brookhaven National (BNL) Laboratory is a multidisciplinary laboratory that carries out basic and applied research in the physical, biomedical, and environmental sciences, and in selected energy technologies. It is managed by Brookhaven Science Associates, LLC, under contract with the U. S. Department of Energy. BNL's total annual budget has averaged about $450 million. There are about 3,000 employees, and another 4,500 guest scientists and students who come each year to use the Laboratory's facilities and work with the staff. The BNL Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) annually in March, as required by DOE Order 4 13.2, ''Laboratory Directed Research and Development,'' March 5, 1997, and the LDRD Annual Report guidance, updated February 12, 1999. The LDRD Program obtains its funds through the Laboratory overhead pool and operates under the authority of DOE Order 4 13.2. The goals and objectives of BNL's LDRD Program can be inferred from the Program's stated purposes. These are to (1) encourage and support the development of new ideas and technology, (2) promote the early exploration and exploitation of creative and innovative concepts, and (3) develop new ''fundable'' R&D projects and programs. The emphasis is clearly articulated by BNL to be on supporting exploratory research ''which could lead to new programs, projects, and directions'' for the Laboratory. As one of the premier scientific laboratories of the DOE, BNL must continuously foster groundbreaking scientific research. At Brookhaven National Laboratory one such method is through its LDRD Program. This discretionary research and development tool is critical in maintaining the scientific excellence and long-term vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community and foster new science and technology ideas

  12. A Laboratory-Developed TaqMan Array Card for Simultaneous Detection of 19 Enteropathogens

    Science.gov (United States)

    Liu, Jie; Gratz, Jean; Amour, Caroline; Kibiki, Gibson; Becker, Stephen; Janaki, Lalitha; Verweij, Jaco J.; Taniuchi, Mami; Sobuz, Shihab U.; Haque, Rashidul; Haverstick, Doris M.

    2013-01-01

    The TaqMan Array Card (TAC) system is a 384-well singleplex real-time PCR format that has been used to detect multiple infection targets. Here we developed an enteric TaqMan Array Card to detect 19 enteropathogens, including viruses (adenovirus, astrovirus, norovirus GII, rotavirus, and sapovirus), bacteria (Campylobacter jejuni/C. coli, Clostridium difficile, Salmonella, Vibrio cholerae, diarrheagenic Escherichia coli strains including enteroaggregative E. coli [EAEC], enterotoxigenic E. coli [ETEC], enteropathogenic E. coli [EPEC], and Shiga-toxigenic E. coli [STEC]), Shigella/enteroinvasive E. coli (EIEC), protozoa (Cryptosporidium, Giardia lamblia, and Entamoeba histolytica), and helminths (Ascaris lumbricoides and Trichuris trichiura), as well as two extrinsic controls to monitor extraction and amplification efficiency (the bacteriophage MS2 and phocine herpesvirus). Primers and probes were newly designed or adapted from published sources and spotted onto microfluidic cards. Fecal samples were spiked with extrinsic controls, and DNA and RNA were extracted using the QiaAmp Stool DNA minikit and the QuickGene RNA Tissue kit, respectively, and then mixed with Ag-Path-ID One Step real-time reverse transcription-PCR (RT-PCR) reagents and loaded into cards. PCR efficiencies were between 90% and 105%, with linearities of 0.988 to 1. The limit of detection of the assays in the TAC was within a 10-fold difference from the cognate assays performed on plates. Precision testing demonstrated a coefficient of variation of below 5% within a run and 14% between runs. Accuracy was evaluated for 109 selected clinical specimens and revealed an average sensitivity and specificity of 85% and 77%, respectively, compared with conventional methods (including microscopy, culture, and immunoassay) and 98% and 96%, respectively, compared with our laboratory-developed PCR-Luminex assays. This TAC allows fast, accurate, and quantitative detection of a broad spectrum of enteropathogens and

  13. 76 FR 19188 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Science.gov (United States)

    2011-04-06

    ... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical... the panels of the Joint Biomedical Laboratory Research and Development and Clinical Science Research.... Neurobiology-D June 10, 2011 Crowne Plaza DC/Silver Spring. Clinical Research Program June 13, 2011 VA Central...

  14. 75 FR 23847 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Science.gov (United States)

    2010-05-04

    ... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical... panels of the Joint Biomedical Laboratory Research and Development and Clinical Science Research and... & Behav Sci-A June 7, 2010 L'Enfant Plaza Hotel. Clinical Research Program June 9, 2010 *VA Central Office...

  15. Ecotoxicological studies with newly hatched larvae of Concholepas concholepas (Mollusca, Gastropoda): bioassay with secondary-treated kraft pulp mill effluents.

    Science.gov (United States)

    Manríquez, Patricio H; Llanos-Rivera, Alejandra; Galaz, Sylvana; Camaño, Andrés

    2013-12-01

    The Chilean abalone or "loco" (Concholepas concholepas, Bruguière 1789) represent the most economically important marine recourse exploited from inner inshore Management and Exploitation Areas for Benthic Resources along the Chilean coast. In this study, newly-hatched larvae of C. concholepas were investigated as a potential model species for marine ecotoxicological studies. The study developed a behavioral standard protocol for assessing the impact that kraft pulp mill effluents after secondary treatment have on C. concholepas larvae. Under controlled laboratory conditions, newly-hatched larvae were exposed to a series of different concentrations of kraft pulp mill effluents with secondary treatment (Pinus spp. and Eucalyptus spp.), potassium dichromate as standard reference toxicant and effluent-free control conditions. Regardless of the type of effluent the results indicated that diluted kraft pulp effluent with secondary treatment had reduced effect on larval survival. Low larval survivals were only recorded when they were exposed to high concentrations of the reference toxicant. This suggests that C. concholepas larval bioassay is a simple method for monitoring the effects of kraft pulp mill effluents with secondary treatment discharged into the sea. The results indicated that dilution of ca. 1% of the effluent with an elemental chlorine free (ECF) secondary treatment is appropriate for achieving low larval mortalities, such as those obtained under control conditions with filtered seawater, and to minimize their impact on early ontogenetic stages of marine invertebrates such as newly-hatched larvae of C. concholepas. The methodological aspects of toxicological testing and behavioral responses described here with newly-hatched larvae of C. concholepas can be used to evaluate in the future the potential effects of other stressful conditions as other pollutants or changes in seawater pH associated with ocean acidification. © 2013 Elsevier Inc. All rights

  16. Development of sensorial experiments and their implementation into undergraduate laboratories

    Science.gov (United States)

    Bromfield Lee, Deborah Christina

    "Visualization" of chemical phenomena often has been limited in the teaching laboratories to the sense of sight. We have developed chemistry experiments that rely on senses other than eyesight to investigate chemical concepts, make quantitative determinations, and familiarize students with chemical techniques traditionally designed using only eyesight. Multi-sensory learning can benefit all students by actively engaging them in learning through stimulation or an alternative way of experiencing a concept or ideas. Perception of events or concepts usually depends on the information from the different sensory systems combined. The use of multi-sensory learning can take advantage of all the senses to reinforce learning as each sense builds toward a more complete experience of scientific data. Research has shown that multi-sensory representations of scientific phenomena is a valuable tool for enhancing understanding of chemistry as well as displacing misconceptions through experience. Multi-sensory experiences have also been shown to enrich memory performance. There are few experiments published which utilize multiple senses in the teaching laboratory. The sensorial experiments chosen were conceptually similar to experiments currently performed in undergraduate laboratories; however students collect different types of data using multi-sensory observations. The experiments themselves were developed by using chemicals that would provide different sensory changes or capitalizing on sensory observations that were typically overlooked or ignored and obtain similar and precise results as in traditional experiments. Minimizing hazards and using safe practices are especially essential in these experiments as students utilize senses traditionally not allowed to be used in the laboratories. These sensorial experiments utilize typical equipment found in the teaching laboratories as well as inexpensive chemicals in order to aid implementation. All experiments are rigorously tested

  17. PCTFPeval: a web tool for benchmarking newly developed algorithms for predicting cooperative transcription factor pairs in yeast.

    Science.gov (United States)

    Lai, Fu-Jou; Chang, Hong-Tsun; Wu, Wei-Sheng

    2015-01-01

    Computational identification of cooperative transcription factor (TF) pairs helps understand the combinatorial regulation of gene expression in eukaryotic cells. Many advanced algorithms have been proposed to predict cooperative TF pairs in yeast. However, it is still difficult to conduct a comprehensive and objective performance comparison of different algorithms because of lacking sufficient performance indices and adequate overall performance scores. To solve this problem, in our previous study (published in BMC Systems Biology 2014), we adopted/proposed eight performance indices and designed two overall performance scores to compare the performance of 14 existing algorithms for predicting cooperative TF pairs in yeast. Most importantly, our performance comparison framework can be applied to comprehensively and objectively evaluate the performance of a newly developed algorithm. However, to use our framework, researchers have to put a lot of effort to construct it first. To save researchers time and effort, here we develop a web tool to implement our performance comparison framework, featuring fast data processing, a comprehensive performance comparison and an easy-to-use web interface. The developed tool is called PCTFPeval (Predicted Cooperative TF Pair evaluator), written in PHP and Python programming languages. The friendly web interface allows users to input a list of predicted cooperative TF pairs from their algorithm and select (i) the compared algorithms among the 15 existing algorithms, (ii) the performance indices among the eight existing indices, and (iii) the overall performance scores from two possible choices. The comprehensive performance comparison results are then generated in tens of seconds and shown as both bar charts and tables. The original comparison results of each compared algorithm and each selected performance index can be downloaded as text files for further analyses. Allowing users to select eight existing performance indices and 15

  18. NSLS source development laboratory

    International Nuclear Information System (INIS)

    Ben-Zvi, I.; Blum, E.; Johnson, E.D.

    1995-01-01

    The National Synchrotron Light Source (NSLS) has initiated an ambitious project to develop fourth generation radiation sources. To achieve this goal, the Source Development Laboratory (SDL) builds on the experience gained at the NSLS, and at the highly successful BNL Accelerator Test Facility. The SDL accelerator system will consist of a high brightness short pulse linac, a station for coherent synchrotron and transition radiation experiments, a short bunch storage ring, and an ultra-violet free electron laser utilizing the NISUS wiggler. The electrons will be provided by a laser photocathode gun feeding a 210 MeV S-band electron linac, with magnetic bunch compression at 80 MeV. Electron bunches as short as 100 μm with 1 nC charge will be used for pump-probe experiments utilizing coherent transition radiation. Beam will also be injected into a compact storage ring which will be a source of millimeter wave coherent synchrotron radiation. The linac will also serve as the driver for an FEL designed to allow the study of various aspects of single pass amplifiers. The first FEL configuration will be as a self-amplified spontaneous emission (SASE) FEL at 900 nm. Seeded beam and sub-harmonic seeded beam operations will push the output wavelength below 200 nm. Chirped pulse amplification (CPA) operation will also be possible, and a planned energy upgrade (by powering a fifth linac section) to 310 MeV will extend the wavelength range of the FEL to below 100 nm

  19. Laboratories and Demonstrations in Child Development with Unedited Videotapes.

    Science.gov (United States)

    Poole, Debra Ann

    1986-01-01

    Multipurpose demonstrations of child development are easy to produce by videotaping children while they interact with parents, siblings, or friends. Unlike commercial films, videotapes without narration allow students to formulate and test their own research questions. This article describes how to use unedited videotapes for laboratories in…

  20. Flagellation of Pseudomonas aeruginosa in newly divided cells

    Science.gov (United States)

    Zhao, Kun; Lee, Calvin; Anda, Jaime; Wong, Gerard

    2015-03-01

    For monotrichous bacteria, Pseudomonas aeruginosa, after cell division, one daughter cell inherits the old flagellum from its mother cell, and the other grows a new flagellum during or after cell division. It had been shown that the new flagellum grows at the distal pole of the dividing cell when the two daughter cells haven't completely separated. However, for those daughter cells who grow new flagella after division, it still remains unknown at which pole the new flagellum will grow. Here, by combining our newly developed bacteria family tree tracking techniques with genetic manipulation method, we showed that for the daughter cell who did not inherit the old flagellum, a new flagellum has about 90% chances to grow at the newly formed pole. We proposed a model for flagellation of P. aeruginosa.

  1. Laboratory Directed Research and Development FY2010 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, K J

    2011-03-22

    A premier applied-science laboratory, Lawrence Livermore National Laboratory (LLNL) has at its core a primary national security mission - to ensure the safety, security, and reliability of the nation's nuclear weapons stockpile without nuclear testing, and to prevent and counter the spread and use of weapons of mass destruction: nuclear, chemical, and biological. The Laboratory uses the scientific and engineering expertise and facilities developed for its primary mission to pursue advanced technologies to meet other important national security needs - homeland defense, military operations, and missile defense, for example - that evolve in response to emerging threats. For broader national needs, LLNL executes programs in energy security, climate change and long-term energy needs, environmental assessment and management, bioscience and technology to improve human health, and for breakthroughs in fundamental science and technology. With this multidisciplinary expertise, the Laboratory serves as a science and technology resource to the U.S. government and as a partner with industry and academia. This annual report discusses the following topics: (1) Advanced Sensors and Instrumentation; (2) Biological Sciences; (3) Chemistry; (4) Earth and Space Sciences; (5) Energy Supply and Use; (6) Engineering and Manufacturing Processes; (7) Materials Science and Technology; Mathematics and Computing Science; (8) Nuclear Science and Engineering; and (9) Physics.

  2. SHynergie: Development of a virtual project laboratory for monitoring hydraulic stimulations

    Science.gov (United States)

    Renner, Jörg; Friederich, Wolfgang; Meschke, Günther; Müller, Thomas; Steeb, Holger

    2016-04-01

    Hydraulic stimulations are the primary means of developing subsurface reservoirs regarding the extent of fluid transport in them. The associated creation or conditioning of a system of hydraulic conduits involves a range of hydraulic and mechanical processes but also chemical reactions, such as dissolution and precipitation, may affect the stimulation result on time scales as short as hours. In the light of the extent and complexity of these processes, the steering potential for the operator of a stimulation critically depends on the ability to integrate the maximum amount of site-specific information with profound process understanding and a large spectrum of experience. We report on the development of a virtual project laboratory for monitoring hydraulic stimulations within the project SHynergie (http://www.ruhr-uni-bochum.de/shynergie/). The concept of the laboratory envisioned product that constitutes a preparing and accompanying rather than post-processing instrument ultimately accessible to persons responsible for a project over a web-repository. The virtual laboratory consists of a data base, a toolbox, and a model-building environment. Entries in the data base are of two categories. On the one hand, selected mineral and rock properties are provided from the literature. On the other hand, project-specific entries of any format can be made that are assigned attributes regarding their use in a stimulation problem at hand. The toolbox is interactive and allows the user to perform calculations of effective properties and simulations of different types (e.g., wave propagation in a reservoir, hydraulic test). The model component is also hybrid. The laboratory provides a library of models reflecting a range of scenarios but also allows the user to develop a site-specific model constituting the basis for simulations. The laboratory offers the option to use its components following the typical workflow of a stimulation project. The toolbox incorporates simulation

  3. 75 FR 39954 - Oversight of Laboratory Developed Tests; Public Meeting; Change of Meeting Location

    Science.gov (United States)

    2010-07-13

    ...] Oversight of Laboratory Developed Tests; Public Meeting; Change of Meeting Location AGENCY: Food and Drug... location for the upcoming public meeting entitled ``Oversight of Laboratory Developed Tests.'' A new... the public meeting, FDA is announcing in this notice a new location for the public meeting. II. New...

  4. Developing Digital Courseware for a Virtual Nano-Biotechnology Laboratory: A Design-Based Research Approach

    Science.gov (United States)

    Yueh, Hsiu-Ping; Chen, Tzy-Ling; Lin, Weijane; Sheen, Horn-Jiunn

    2014-01-01

    This paper first reviews applications of multimedia in engineering education, especially in laboratory learning. It then illustrates a model and accreditation criteria adopted for developing a specific set of nanotechnology laboratory courseware and reports the design-based research approach used in designing and developing the e-learning…

  5. Description of the EDF research and development laboratory's radiographic picture processing system

    International Nuclear Information System (INIS)

    Brillault, B.

    1985-01-01

    A digital radiographic picture processing system has been developed at the EDF Research and Development Laboratory to be supplied to EDF radiography experts. We describe it in pointing out the difficulties of radiograph digitization but also the numerous processing possibilities. The final goal of the Laboratory work is to extract the information from industrial radiographs by digital means. Our study is divided into three parts: digitization by a microdensitometer; display, processing and quantization of flaws; and, digital storing. 5 refs

  6. Surface ultrastuctures of the human laryngeal mucosa - observation by an newly developed technique of SEM cinematography

    International Nuclear Information System (INIS)

    Ohyama, M.; Ohno, I.; Fujita, T.; Adachi, K.

    1981-01-01

    With the newly-developed techniques of SEM cinematography, surface ultrastructures of the human normal and pathological laryngeal mucosa were demonstrated. The high specialization of the laryngeal mucosa with its marked regional differences stresses the fact that even the squamous epithelium and nonciliated epithelium may play a role of utmost importance. All specimens were obtained after laryngectomy from 10 patients affected by laryngeal cancer which had been treated with or without preoperative irradiation of Lineac in total doses of 3,500-4,500 rad. Special attention was paid to the occurrence of microvilli and microplicae in the normal and pathological mucosa of the larynx, and their morphological and physiological significances were discussed briefly. (Auth.)

  7. Transferability of Newly Developed Pear SSR Markers to Other Rosaceae Species.

    Science.gov (United States)

    Fan, L; Zhang, M-Y; Liu, Q-Z; Li, L-T; Song, Y; Wang, L-F; Zhang, S-L; Wu, J

    2013-01-01

    A set of 120 simple sequence repeats (SSRs) was developed from the newly assembled pear sequence and evaluated for polymorphisms in seven genotypes of pear from different genetic backgrounds. Of these, 67 (55.8 %) primer pairs produced polymorphic amplifications. Together, the 67 SSRs detected 277 alleles with an average of 4.13 per locus. Sequencing of the amplification products from randomly picked loci NAUPy31a and NAUpy53a verified the presence of the SSR loci. When the 67 primer pairs were tested on 96 individual members of eight species in the Rosaceae family, 61.2 % (41/67) of the tested SSRs successfully amplified a PCR product in at least one of the Rosaceae genera. The transferability from pear to different species varied from 58.2 % (apple) to 11.9 % (cherry). The ratio of transferability also reflected the closer relationships within Maloideae over Prunoideae. Two pear SSR markers, NAUpy43c and NAUpy55k, could distinguish the 20 different apple genotypes thoroughly, and UPGMA cluster analysis grouped them into three groups at the similarity level of 0.56. The high level of polymorphism and good transferability of pear SSRs to Rosaceae species indicate their promise for application to future molecular screening, map construction, and comparative genomic studies among pears and other Rosaceae species.

  8. First Year Chemistry Laboratory Courses for Distance Learners: Development and Transfer Credit Acceptance

    Directory of Open Access Journals (Sweden)

    Sharon E. Brewer,

    2013-07-01

    Full Text Available In delivering chemistry courses by distance, a key challenge is to offer the learner an authentic and meaningful laboratory experience that still provides the rigour required to continue on in science. To satisfy this need, two distance general chemistry laboratory courses appropriate for Bachelor of Science (B.Sc. students, including chemistry majors, have been recently developed at Thompson Rivers University. A constructive alignment process was employed which clearly mapped learning outcomes and activities to appropriate assessment tools. These blended laboratory courses feature custom, home experimental kits and combine elements of online and hands-on learning. The courses were designed for flexible continuous enrollment and provide online resources including tutor support, instructional videos, lab report submission, and student evaluation. The assessment of students includes laboratory reports, safety quizzes, reflective journaling, digital photo documentation, and invigilated written and online practical exams. Emphasizing the quality and rigour in these distance laboratory learning experiences allowed both courses to be accepted for B.Sc. transfer credit by other institutions, an important criterion for students. This paper will outline the design and development process of these new blended laboratory courses, their course structures and assessments, and initial student results.

  9. Cyclotron Development and Technical Aspects on Accelerator Based Laboratory Development

    International Nuclear Information System (INIS)

    Sunarhadijoso

    2000-01-01

    BATAN is planning to establish an accelerator-based laboratory at P3TM Yogyakarta as an effort in the development and use of accelerator technology for improving industrial performance and public welfare. This paper reviews several aspects of cyclotron technology and describes the combination of a linear accelerator - cyclotron system as an alternative to be considered in the planing of the laboratory. The progress of cyclotron technology is discussed covering three generations, i.e. conventional cyclotron, synchrocyclotron and AVF cyclotron generations. The planning should not consider the accelerator application for radioisotope production because it is established in Serpong with the existing negative ion cyclotron. The proposed facility at P3TM may comprise two linear accelerators coupled with a positive ion cyclotron of synchrocyclotron generation. In fact, the attachment of the synchrocyclotron unit is flexible and it can be installed subsequently if the higher energy particle beam, which can not be produced by the linear accelerators, is extremely needed. Some technical aspects related to ion beam application, building construction and infrastructure, human resources, and specification of function test are discussed for additional information in the implementation of the planning. (author)

  10. Laboratory Directed Research and Development Annual Report - Fiscal Year 2000

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, Darrell R.; Hughes, Pamela J.; Pearson, Erik W.

    2001-04-01

    The projects described in this report represent the Laboratory's investment in its future and are vital to maintaining the ability to develop creative solutions for the scientific and technical challenges faced by DOE and the nation. In accordance with DOE guidelines, the report provides, a) a director's statement, b) an overview of the laboratory's LDRD program, including PNNL's management process and a self-assessment of the program, c) a five-year project funding table, and d) project summaries for each LDRD project.

  11. Laboratory Directed Research and Development FY2011 Annual Report

    International Nuclear Information System (INIS)

    Craig, W.; Sketchley, J.; Kotta, P.

    2012-01-01

    A premier applied-science laboratory, Lawrence Livermore National Laboratory (LLNL) has earned the reputation as a leader in providing science and technology solutions to the most pressing national and global security problems. The LDRD Program, established by Congress at all DOE national laboratories in 1991, is LLNL's most important single resource for fostering excellent science and technology for today's needs and tomorrow's challenges. The LDRD internally directed research and development funding at LLNL enables high-risk, potentially high-payoff projects at the forefront of science and technology. The LDRD Program at Livermore serves to: (1) Support the Laboratory's missions, strategic plan, and foundational science; (2) Maintain the Laboratory's science and technology vitality; (3) Promote recruiting and retention; (4) Pursue collaborations; (5) Generate intellectual property; and (6) Strengthen the U.S. economy. Myriad LDRD projects over the years have made important contributions to every facet of the Laboratory's mission and strategic plan, including its commitment to nuclear, global, and energy and environmental security, as well as cutting-edge science and technology and engineering in high-energy-density matter, high-performance computing and simulation, materials and chemistry at the extremes, information systems, measurements and experimental science, and energy manipulation. A summary of each project was submitted by the principal investigator. Project summaries include the scope, motivation, goals, relevance to DOE/NNSA and LLNL mission areas, the technical progress achieved in FY11, and a list of publications that resulted from the research. The projects are: (1) Nuclear Threat Reduction; (2) Biosecurity; (3) High-Performance Computing and Simulation; (4) Intelligence; (5) Cybersecurity; (6) Energy Security; (7) Carbon Capture; (8) Material Properties, Theory, and Design; (9) Radiochemistry; (10) High-Energy-Density Science; (11) Laser Inertial

  12. Cross-Linking Mast Cell Specific Gangliosides Stimulates the Release of Newly Formed Lipid Mediators and Newly Synthesized Cytokines

    Directory of Open Access Journals (Sweden)

    Edismauro Garcia Freitas Filho

    2016-01-01

    Full Text Available Mast cells are immunoregulatory cells that participate in inflammatory processes. Cross-linking mast cell specific GD1b derived gangliosides by mAbAA4 results in partial activation of mast cells without the release of preformed mediators. The present study examines the release of newly formed and newly synthesized mediators following ganglioside cross-linking. Cross-linking the gangliosides with mAbAA4 released the newly formed lipid mediators, prostaglandins D2 and E2, without release of leukotrienes B4 and C4. The effect of cross-linking these gangliosides on the activation of enzymes in the arachidonate cascade was then investigated. Ganglioside cross-linking resulted in phosphorylation of cytosolic phospholipase A2 and increased expression of cyclooxygenase-2. Translocation of 5-lipoxygenase from the cytosol to the nucleus was not induced by ganglioside cross-linking. Cross-linking of GD1b derived gangliosides also resulted in the release of the newly synthesized mediators, interleukin-4, interleukin-6, and TNF-α. The effect of cross-linking the gangliosides on the MAP kinase pathway was then investigated. Cross-linking the gangliosides induced the phosphorylation of ERK1/2, JNK1/2, and p38 as well as activating both NFκB and NFAT in a Syk-dependent manner. Therefore, cross-linking the mast cell specific GD1b derived gangliosides results in the activation of signaling pathways that culminate with the release of newly formed and newly synthesized mediators.

  13. Development and testing of a mobile application to support diabetes self-management for people with newly diagnosed type 2 diabetes: a design thinking case study.

    Science.gov (United States)

    Petersen, Mira; Hempler, Nana F

    2017-06-26

    Numerous mobile applications have been developed to support diabetes-self-management. However, the majority of these applications lack a theoretical foundation and the involvement of people with diabetes during development. The aim of this study was to develop and test a mobile application (app) supporting diabetes self-management among people with newly diagnosed type 2 diabetes using design thinking. The app was developed and tested in 2015 using a design-based research approach involving target users (individuals newly diagnosed with type 2 diabetes), research scientists, healthcare professionals, designers, and app developers. The research approach comprised three major phases: inspiration, ideation, and implementation. The first phase included observations of diabetes education and 12 in-depth interviews with users regarding challenges and needs related to living with diabetes. The ideation phrase consisted of four interactive workshops with users focusing on app needs, in which ideas were developed and prioritized. Finally, 14 users tested the app over 4 weeks; they were interviewed about usability and perceptions about the app as a support tool. A multifunctional app was useful for people with newly diagnosed type 2 diabetes. The final app comprised five major functions: overview of diabetes activities after diagnosis, recording of health data, reflection games and goal setting, knowledge games and recording of psychological data such as sleep, fatigue, and well-being. Users found the app to be a valuable tool for support, particularly for raising their awareness about their psychological health and for informing and guiding them through the healthcare system after diagnosis. The design thinking processes used in the development and implementation of the mobile health app were crucial to creating value for users. More attention should be paid to the training of professionals who introduce health apps. Danish Data Protection Agency: 2012-58-0004. Registered 6

  14. Newly Homeless Youth Typically Return Home

    OpenAIRE

    Milburn, Norweeta G.; Rosenthal, Doreen; Rotheram-Borus, Mary Jane; Mallett, Shelley; Batterham, Philip; Rice, Eric; Solorio, Rosa

    2007-01-01

    165 newly homeless adolescents from Melbourne, Australia and 261 from Los Angeles, United States were surveyed and followed for two years. Most newly homeless adolescents returned home (70% U.S., 47% Australia) for significant amounts of time (39% U.S., 17% Australia more than 12 months) within two years of becoming homeless.

  15. Nanotechnology Laboratory Collaborates with Army to Develop Botulism Vaccine | FNLCR

    Science.gov (United States)

    The Nanotechnology Characterization Laboratory (NCL) is collaborating with the Army to develop a candidate vaccine against botulism. Under a collaboration agreement between the National Cancer Institute and the U.S. Army Medical Research Institute of

  16. Technetium-99m carboxymethylcellulose: A newly developed fibre marker for gastric emptying studies

    International Nuclear Information System (INIS)

    Schade, J.H.; Hoving, J.; Brouweres, J.R.B.J.; Riedstra-van Gent, H.G.; Zijlstra, J.; Dijkstra, J.P.H.

    1991-01-01

    We report a study of technetium-99m-labelled carboxymethyl-cellulose ( 99m Tc-CMC) as a newly developed non-digestible marker of the solid phase of gastric contents. The radiosynthesis is simple and shows a high labelling efficiency. In vitro and in vivo experiments demonstrated stability of the marker in the gastrointestinal tract during the process of gastric emptying. The gastric half-emptying time in ten healthy volunteers of both sexes was 105±17 min (mean±SD). This rate of gastric emptying is similar to that of non-digestible solid-phase markers such as in vivo labelled 99m Tc-chicken liver or radio-iodinated cellulose. In comparison with digestible solid-phase markers such as 99m Tc-labelled pancake or 99m Tc-cooked egg, gastric emptying of 99m Tc-CMC occurred more slowly, confirming the expected behaviour of a non-digestible solid-phase marker. We conclude that 99m Tc-CMC has the advantage of a simple and rapid labelling procedure and may be useful for clinical studies of gastric emptying. (orig.)

  17. Laboratory infrastructure driven key performance indicator development using the smart grid architecture model

    DEFF Research Database (Denmark)

    Syed, Mazheruddin H.; Guillo-Sansano, Efren; Blair, Steven M.

    2017-01-01

    This study presents a methodology for collaboratively designing laboratory experiments and developing key performance indicators for the testing and validation of novel power system control architectures in multiple laboratory environments. The contribution makes use of the smart grid architecture...

  18. Measurement agreement between a newly developed sensing insole and traditional laboratory-based method for footstrike pattern detection in runners

    Science.gov (United States)

    Cheung, Roy T. H.; An, Winko W.; Au, Ivan P. H.; Zhang, Janet H.; Chan, Zoe Y. S.; Man, Alfred; Lau, Fannie O. Y.; Lam, Melody K. Y.; Lau, K. K.; Leung, C. Y.; Tsang, N. W.; Sze, Louis K. Y.; Lam, Gilbert W. K.

    2017-01-01

    This study introduced a novel but simple method to continuously measure footstrike patterns in runners using inexpensive force sensors. Two force sensing resistors were firmly affixed at the heel and second toe of both insoles to collect the time signal of foot contact. A total of 109 healthy young adults (42 males and 67 females) were recruited in this study. They ran on an instrumented treadmill at 0°, +10°, and -10° inclinations and attempted rearfoot, midfoot, and forefoot landings using real time visual biofeedback. Intra-step strike index and onset time difference between two force sensors were measured and analyzed with univariate linear regression. We analyzed 25,655 footfalls and found that onset time difference between two sensors explained 80–84% of variation in the prediction model of strike index (R-squared = 0.799–0.836, p<0.001). However, the time windows to detect footstrike patterns on different surface inclinations were not consistent. These findings may allow laboratory-based gait retraining to be implemented in natural running environments to aid in both injury prevention and performance enhancement. PMID:28599003

  19. Measurement agreement between a newly developed sensing insole and traditional laboratory-based method for footstrike pattern detection in runners.

    Directory of Open Access Journals (Sweden)

    Roy T H Cheung

    Full Text Available This study introduced a novel but simple method to continuously measure footstrike patterns in runners using inexpensive force sensors. Two force sensing resistors were firmly affixed at the heel and second toe of both insoles to collect the time signal of foot contact. A total of 109 healthy young adults (42 males and 67 females were recruited in this study. They ran on an instrumented treadmill at 0°, +10°, and -10° inclinations and attempted rearfoot, midfoot, and forefoot landings using real time visual biofeedback. Intra-step strike index and onset time difference between two force sensors were measured and analyzed with univariate linear regression. We analyzed 25,655 footfalls and found that onset time difference between two sensors explained 80-84% of variation in the prediction model of strike index (R-squared = 0.799-0.836, p<0.001. However, the time windows to detect footstrike patterns on different surface inclinations were not consistent. These findings may allow laboratory-based gait retraining to be implemented in natural running environments to aid in both injury prevention and performance enhancement.

  20. Project development laboratories energy fuels and oils based on NRU “MPEI”

    Science.gov (United States)

    Burakov, I. A.; Burakov, A. Y.; Nikitina, I. S.; Khomenkov, A. M.; Paramonova, A. O.; Khtoo Naing, Aung

    2017-11-01

    In the process of improving the efficiency of power plants a hot topic is the use of high-quality fuels and lubricants. In the process of transportation, preparation for use, storage and maintenance of the properties of fuels and lubricants may deteriorate, which entails a reduction in the efficiency of power plants. One of the ways to prevent the deterioration of the properties is a timely analysis of the relevant laboratories. In this day, the existence of laboratories of energy fuels and energy laboratory oil at thermal power stations is satisfactory character. However, the training of qualified personnel to work in these laboratories is a serious problem, as the lack of opportunities in these laboratories a complete list of required tests. The solution to this problem is to explore the possibility of application of methods of analysis of the properties of fuels and lubricants in the stage of training and re-training of qualified personnel. In this regard, on the basis of MPEI developed laboratory projects of solid, liquid and gaseous fuels, power and energy oils and lubricants. Projects allow for a complete list of tests required for the timely control of properties and prevent the deterioration of these properties. Assess the financial component of the implementation of the developed projects based on the use of modern equipment used for tests. Projects allow for a complete list of tests required for the timely control of properties and prevent the deterioration of these properties.

  1. Development and Implementation of a Quality Improvement Process for Echocardiographic Laboratory Accreditation.

    Science.gov (United States)

    Gilliland, Yvonne E; Lavie, Carl J; Ahmad, Homaa; Bernal, Jose A; Cash, Michael E; Dinshaw, Homeyar; Milani, Richard V; Shah, Sangeeta; Bienvenu, Lisa; White, Christopher J

    2016-03-01

    We describe our process for quality improvement (QI) for a 3-year accreditation cycle in echocardiography by the Intersocietal Accreditation Commission (IAC) for a large group practice. Echocardiographic laboratory accreditation by the IAC was introduced in 1996, which is not required but could impact reimbursement. To ensure high-quality patient care and community recognition as a facility committed to providing high-quality echocardiographic services, we applied for IAC accreditation in 2010. Currently, there is little published data regarding the IAC process to meet echocardiography standards. We describe our approach for developing a multicampus QI process for echocardiographic laboratory accreditation during the 3-year cycle of accreditation by the IAC. We developed a quarterly review assessing (1) the variability of the interpretations, (2) the quality of the examinations, (3) a correlation of echocardiographic studies with other imaging modalities, (4) the timely completion of reports, (5) procedure volume, (6) maintenance of Continuing Medical Education credits by faculty, and (7) meeting Appropriate Use Criteria. We developed and implemented a multicampus process for QI during the 3-year accreditation cycle by the IAC for Echocardiography. We documented both the process and the achievement of those metrics by the Echocardiography Laboratories at the Ochsner Medical Institutions. We found the QI process using IAC standards to be a continuous educational experience for our Echocardiography Laboratory physicians and staff. We offer our process as an example and guide for other echocardiography laboratories who wish to apply for such accreditation or reaccreditation. © 2016, Wiley Periodicals, Inc.

  2. THE NEXUS BETWEEN ENERGY CONSUMPTION AND FINANCIAL DEVELOPMENT WITH ASYMMETRIC CAUSALITY TEST: NEW EVIDENCE FROM NEWLY INDUSTRIALIZED COUNTRIES

    Directory of Open Access Journals (Sweden)

    Feyyaz Zeren

    2014-01-01

    Full Text Available In this study, the relationship between energy consumption and financial development is investigated via Hatemi-J asymmetric causality test (2012 which is able to separate positive and negative shocks in analysis. In order to determine different dimensions of financial system, deposit money bank assets to GDP (dbagdp, financial system deposits to GDP (fdgdp and private credit to GDP (pcrdbgdp were used as three different indicators. As a result of this study on Newly Industrialized 7 Countries spanning the period 1971 till 2010, both positive and negative shocks existed for Malaysia and Mexico, causality from energy consumption to financial developments emerged for Philippines in only negative shocks. While two-way causality occurred for India, Turkey and Thailand, there was not for South Africa.

  3. Submillimeter laboratory identification of CH{sup +} and CH{sub 2}D{sup +}

    Energy Technology Data Exchange (ETDEWEB)

    Amano, T. [Department of Chemistry and Department of Physics and Astronomy, University of Waterloo, Waterloo, ON N2L 3G1 (Canada)

    2015-01-22

    Laboratory identification of two basic and important interstellar molecular ions is presented. The J = 1 - 0 rotational transition of {sup 12}CH{sup +} together with those of {sup 13}CH{sup +} and {sup 12}CD{sup +} was observed in the laboratory. The newly obtained frequencies were found to be different from those reported previously. Various experimental evidences firmly support the new measurements. In addition, the Zeeman effect and the spin-rotation hyperfine interaction enforce the laboratory identification with no ambiguity. Rotational lines of CH{sub 2}D{sup +} were observed in the submillimeter-wave region. This laboratory observation is consistent with a recent tentative identification of CH{sub 2}D{sup +} toward Ori IRc2.

  4. Design of an X-band accelerating structure using a newly developed structural optimization procedure

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Xiaoxia [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Fang, Wencheng; Gu, Qiang [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China); Zhao, Zhentang, E-mail: zhaozhentang@sinap.ac.cn [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China); University of Chinese Academy of Sciences, Beijing 100049 (China)

    2017-05-11

    An X-band high gradient accelerating structure is a challenging technology for implementation in advanced electron linear accelerator facilities. The present work discusses the design of an X-band accelerating structure for dedicated application to a compact hard X-ray free electron laser facility at the Shanghai Institute of Applied Physics, and numerous design optimizations are conducted with consideration for radio frequency (RF) breakdown, RF efficiency, short-range wakefields, and dipole/quadrupole field modes, to ensure good beam quality and a high accelerating gradient. The designed X-band accelerating structure is a constant gradient structure with a 4π/5 operating mode and input and output dual-feed couplers in a racetrack shape. The design process employs a newly developed effective optimization procedure for optimization of the X-band accelerating structure. In addition, the specific design of couplers providing high beam quality by eliminating dipole field components and reducing quadrupole field components is discussed in detail.

  5. Duplex ultrasound: Indications and findings in a newly created ...

    African Journals Online (AJOL)

    Duplex ultrasound: Indications and findings in a newly created facility at the University of Calabar Teaching Hospital, Calabar. ... It is recommended that timely referrals be made, and mobile Doppler units be acquired to save more lives and limbs in the developing world. Keywords: Calabar, deep venous thrombosis, duplex ...

  6. Competence of newly qualified registered nurses from a nursing college

    Directory of Open Access Journals (Sweden)

    BG Morolong

    2005-09-01

    Full Text Available The South African education and training system, through its policy of outcomesbased education and training, has made competency a national priority. In compliance to this national requirement of producing competent learners, the South African Nursing Council ( 1999 B require that the beginner professional nurse practitioners and midwives have the necessary knowledge, skills, attitudes and values which will enable them to render efficient professional service. The health care system also demands competent nurse practitioners to ensure quality in health care. In the light of competency being a national priority and a statutory demand, the research question that emerges is, how competent are the newly qualified registered nurses from a specific nursing college in clinical nursing education? A quantitative, non-experimental contextual design was used to evaluate the competence of newly qualified registered nurses from a specific nursing college. The study was conducted in two phases. The first phase dealt with the development of an instrument together with its manual through the conceptualisation process. The second phase focused on the evaluation of the competency of newly qualified nurses using the instrument based on the steps of the nursing process. A pilot study was conducted to test the feasibility of the items of the instrument. During the evaluation phase, a sample of twenty-six newly qualified nurses was selected by simple random sampling from a target population of thirty-six newly qualified registered nurses. However, six participants withdrew from the study. Data was collected in two general hospitals where the newly qualified registered nurses were working. Observation and questioning were used as data collection techniques in accordance with the developed instrument. Measures were taken to ensure internal validity and reliability of the results. To protect the rights of the participants, the researcher adhered to DENOSA’S (1998

  7. Development, Evaluation and Use of a Student Experience Survey in Undergraduate Science Laboratories: The Advancing Science by Enhancing Learning in the Laboratory Student Laboratory Learning Experience Survey

    Science.gov (United States)

    Barrie, Simon C.; Bucat, Robert B.; Buntine, Mark A.; Burke da Silva, Karen; Crisp, Geoffrey T.; George, Adrian V.; Jamie, Ian M.; Kable, Scott H.; Lim, Kieran F.; Pyke, Simon M.; Read, Justin R.; Sharma, Manjula D.; Yeung, Alexandra

    2015-07-01

    Student experience surveys have become increasingly popular to probe various aspects of processes and outcomes in higher education, such as measuring student perceptions of the learning environment and identifying aspects that could be improved. This paper reports on a particular survey for evaluating individual experiments that has been developed over some 15 years as part of a large national Australian study pertaining to the area of undergraduate laboratories-Advancing Science by Enhancing Learning in the Laboratory. This paper reports on the development of the survey instrument and the evaluation of the survey using student responses to experiments from different institutions in Australia, New Zealand and the USA. A total of 3153 student responses have been analysed using factor analysis. Three factors, motivation, assessment and resources, have been identified as contributing to improved student attitudes to laboratory activities. A central focus of the survey is to provide feedback to practitioners to iteratively improve experiments. Implications for practitioners and researchers are also discussed.

  8. A newly developed grab sampling system for collecting stratospheric air over Antarctica

    Directory of Open Access Journals (Sweden)

    Hideyuki Honda

    1996-07-01

    Full Text Available In order to measure the concentrations of various minor constituents and their isotopic ratios in the stratosphere over Antarctica, a simple grab sampling system was newly developed. The sampling system was designed to be launched by a small number of personnel using a rubber balloon under severe experimental conditions. Special attention was paid to minimize the contamination of sample air, as well as to allow easy handling of the system. The sampler consisted mainly of a 15l sample container with electromagnetic and manual valves, control electronics for executing the air sampling procedures and sending the position and status information of the sampler to the ground station, batteries and a transmitter. All these parts were assembled in an aluminum frame gondola with a shock absorbing system for landing. The sampler was equipped with a turn-over mechanism of the gondola to minimize contamination from the gondola, as well as with a GPS receiver and a rawinsonde for its tracking. Total weight of the sampler was about 11kg. To receive, display and store the position and status data of the sampling system at the ground station, a simple data acquisition system with a portable receiver and a microcomputer was also developed. A new gas handling system was prepared to simplify the injection of He gas into the balloon. For air sampling experiments, three sampling systems were launched at Syowa Station (69°00′S, 39°35′E, Antarctica and then recovered on sea ice near the station on January 22 and 25,1996.

  9. Evaluation of newly developed veterinary portable blood glucose meter with hematocrit correction in dogs and cats.

    Science.gov (United States)

    Mori, Akihiro; Oda, Hitomi; Onozawa, Eri; Shono, Saori; Sako, Toshinori

    2017-10-07

    This study evaluated the accuracy of a newly developed veterinary portable blood glucose meter (PBGM) with hematocrit correction in dogs and cats. Sixty-one dogs and 31 cats were used for the current study. Blood samples were obtained from each dog and cat one to six times. Acceptable results were obtained in error grid analysis between PBGM and reference method values (glucose oxidation methods) in both dogs and cats. Bland-Altman plot analysis revealed a mean difference between the PBGM value and reference method value of -1.975 mg/dl (bias) in dogs and 1.339 mg/dl (bias) in cats. Hematocrit values did not affect the results of the veterinary PBGM. Therefore, this veterinary PBGM is clinically useful in dogs and cats.

  10. Newly-graduated midwives transcending barriers: a grounded theory study.

    Science.gov (United States)

    Barry, Michele J; Hauck, Yvonne L; O'Donoghue, Thomas; Clarke, Simon

    2013-12-01

    Midwifery has developed its own philosophy to formalise its unique identity as a profession. Newly-graduated midwives are taught, and ideally embrace, this philosophy during their education. However, embarking in their career within a predominantly institutionalised and the medically focused health-care model may challenge this application. The research question guiding this study was as follows: 'How do newly graduated midwives deal with applying the philosophy of midwifery in their first six months of practice?' The aim was to generate a grounded theory around this social process. This Western Australian grounded theory study is conceptualised within the social theory of symbolic interactionism. Data were collected by means of in-depth, semi-structured interviews with 11 recent midwifery graduates. Participant and interviewer's journals provided supplementary data. The 'constant comparison' approach was used for data analysis. The substantive theory of transcending barriers was generated. Three stages in transcending barriers were identified: Addressing personal attributes, Understanding the 'bigger picture', and finally, 'Evaluating, planning and acting' to provide woman-centred care. An overview of these three stages provides the focus of this article. The theory of transcending barriers provides a new perspective on how newly-graduated midwives deal with applying the philosophy of midwifery in their first six months of practice. A number of implications for pre and post registration midwifery education and policy development are suggested, as well as recommendations for future research. Copyright © 2013 Elsevier Ltd. All rights reserved.

  11. A newly developed lubricant, chitosan laurate, in the manufacture of acetaminophen tablets.

    Science.gov (United States)

    Bani-Jaber, Ahmad; Kobayashi, Asuka; Yamada, Kyohei; Haj-Ali, Dana; Uchimoto, Takeaki; Iwao, Yasunori; Noguchi, Shuji; Itai, Shigeru

    2015-04-10

    To study the usefulness of chitosan laurate (CS-LA), a newly developed chitosan salt, as a lubricant, lubrication properties such as the pressure transmission ratio and ejection force were determined at different concentrations of CS-LA in tableting. In addition, tablet properties such as the tensile strength, disintegration time, and dissolution behavior, were also determined. When CS-LA was mixed at concentrations of 0.1%-3.0%, the pressure transmission ratio was increased in a concentration-dependent manner, and the value at a CS-LA concentration of 3% was equal to that of magnesium stearate (Mg-St), a widely used lubricant. Additionally, a reduction in the ejection force was observed at a concentration from 1%, proving that CS-LA has good lubrication performance. A prolonged disintegration time and decreased tensile strength, which are known disadvantages of Mg-St, were not observed with CS-LA. Furthermore, with CS-LA, retardation of dissolution of the drug from the tablets was not observed. Conjugation of CS with LA was found to be quite important for both lubricant and tablet properties. In conclusion, CS-LA should be useful as an alternative lubricant to Mg-St. Copyright © 2015 Elsevier B.V. All rights reserved.

  12. Arctic Energy Technology Development Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Sukumar Bandopadhyay; Charles Chamberlin; Robert Chaney; Gang Chen; Godwin Chukwu; James Clough; Steve Colt; Anthony Covescek; Robert Crosby; Abhijit Dandekar; Paul Decker; Brandon Galloway; Rajive Ganguli; Catherine Hanks; Rich Haut; Kristie Hilton; Larry Hinzman; Gwen Holdman; Kristie Holland; Robert Hunter; Ron Johnson; Thomas Johnson; Doug Kame; Mikhail Kaneveskly; Tristan Kenny; Santanu Khataniar; Abhijeet Kulkami; Peter Lehman; Mary Beth Leigh; Jenn-Tai Liang; Michael Lilly; Chuen-Sen Lin; Paul Martin; Pete McGrail; Dan Miller; Debasmita Misra; Nagendra Nagabhushana; David Ogbe; Amanda Osborne; Antoinette Owen; Sharish Patil; Rocky Reifenstuhl; Doug Reynolds; Eric Robertson; Todd Schaef; Jack Schmid; Yuri Shur; Arion Tussing; Jack Walker; Katey Walter; Shannon Watson; Daniel White; Gregory White; Mark White; Richard Wies; Tom Williams; Dennis Witmer; Craig Wollard; Tao Zhu

    2008-12-31

    The Arctic Energy Technology Development Laboratory was created by the University of Alaska Fairbanks in response to a congressionally mandated funding opportunity through the U.S. Department of Energy (DOE), specifically to encourage research partnerships between the university, the Alaskan energy industry, and the DOE. The enabling legislation permitted research in a broad variety of topics particularly of interest to Alaska, including providing more efficient and economical electrical power generation in rural villages, as well as research in coal, oil, and gas. The contract was managed as a cooperative research agreement, with active project monitoring and management from the DOE. In the eight years of this partnership, approximately 30 projects were funded and completed. These projects, which were selected using an industry panel of Alaskan energy industry engineers and managers, cover a wide range of topics, such as diesel engine efficiency, fuel cells, coal combustion, methane gas hydrates, heavy oil recovery, and water issues associated with ice road construction in the oil fields of the North Slope. Each project was managed as a separate DOE contract, and the final technical report for each completed project is included with this final report. The intent of this process was to address the energy research needs of Alaska and to develop research capability at the university. As such, the intent from the beginning of this process was to encourage development of partnerships and skills that would permit a transition to direct competitive funding opportunities managed from funding sources. This project has succeeded at both the individual project level and at the institutional development level, as many of the researchers at the university are currently submitting proposals to funding agencies, with some success.

  13. Immunoparesis in newly diagnosed Multiple Myeloma patients

    DEFF Research Database (Denmark)

    Sorrig, Rasmus; Klausen, Tobias W.; Salomo, Morten

    2017-01-01

    Immunoparesis (hypogammaglobulinemia) is associated to an unfavorable prognosis in newly diagnosed Multiple myeloma (MM) patients. However, this finding has not been validated in an unselected population-based cohort. We analyzed 2558 newly diagnosed MM patients in the Danish Multiple Myeloma...

  14. Development policy for the Brazilian health industry and qualification of national public laboratories

    Directory of Open Access Journals (Sweden)

    Ana Luiza d'Ávila Viana

    Full Text Available Abstract: Technological innovations play a decisive role in societies' development by contributing to economic growth and the population's welfare. The state has a key role in this process by inducing innovative behavior, strategies, and decisions. This study addresses Brazil's current policy for development of the health industry and its effects on qualification of national public laboratories by contextualizing different cycles of interaction between health policy and the industrial base, discussing the government's development strategy and the transfer and absorption of health technology (through Industrial Development Partnerships, and presenting two current partnerships involving public laboratories in the production of medicines and vaccines.

  15. Laboratory Directed Research and Development Program FY 2006

    Energy Technology Data Exchange (ETDEWEB)

    Hansen (Ed.), Todd

    2007-03-08

    The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab or LBNL) is a multi-program national research facility operated by the University of California for the Department of Energy (DOE). As an integral element of DOE's National Laboratory System, Berkeley Lab supports DOE's missions in fundamental science, energy resources, and environmental quality. Berkeley Lab programs advance four distinct goals for DOE and the nation: (1) To perform leading multidisciplinary research in the computing sciences, physical sciences, energy sciences, biosciences, and general sciences in a manner that ensures employee and public safety and protection of the environment. (2) To develop and operate unique national experimental facilities for qualified investigators. (3) To educate and train future generations of scientists and engineers to promote national science and education goals. (4) To transfer knowledge and technological innovations and to foster productive relationships among Berkeley Lab's research programs, universities, and industry in order to promote national economic competitiveness.

  16. Annual report 1991 of Munich University and Technical University Accelerator Laboratory

    International Nuclear Information System (INIS)

    1992-01-01

    The experimental work in the Accelerator Laboratory contains investigations of nuclear reactions and nuclear structure, studies of atom physics and the application of nuclear physics methods in physics and in interdisciplinary research. These applications are acceleration mass spectrometry to detect traces of radio-isotopes and material analysis with particle beams. The development of apparatus in the fields of accelereator construction, ion sources and targets are at the heart of the laboratory and help to establish its reputation. They are of the greatest importance for the education of students. The development stage for the superconducting post-accelerator TRITRON is complete and prototypes of the magnets and resonators were successfully tested and operated. The mass-production of all the components is under way or already finished. The standard injector for the tandem axxelerator and an injector for accelerator mass spectroscopy with stable isotopes are being newly designed. The experimental work is supplemented by the calculations of our theoretical collagues of core reaction mechanisms, core de-excitation and the Cerenkov radiation of core structures and transition strengths, by relativistic Hartree-Fock calculations and by star model calculations. (orig.) [de

  17. Laboratory Directed Research and Development Annual Report - Fiscal Year 2000; FINAL

    International Nuclear Information System (INIS)

    Fisher, Darrell R; Hughes, Pamela J; Pearson, Erik W

    2001-01-01

    The projects described in this report represent the Laboratory's investment in its future and are vital to maintaining the ability to develop creative solutions for the scientific and technical challenges faced by DOE and the nation. In accordance with DOE guidelines, the report provides, (a) a director's statement, (b) an overview of the laboratory's LDRD program, including PNNL's management process and a self-assessment of the program, (c) a five-year project funding table, and (d) project summaries for each LDRD project

  18. Laboratory Directed Research and Development FY2011 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Craig, W; Sketchley, J; Kotta, P

    2012-03-22

    A premier applied-science laboratory, Lawrence Livermore National Laboratory (LLNL) has earned the reputation as a leader in providing science and technology solutions to the most pressing national and global security problems. The LDRD Program, established by Congress at all DOE national laboratories in 1991, is LLNL's most important single resource for fostering excellent science and technology for today's needs and tomorrow's challenges. The LDRD internally directed research and development funding at LLNL enables high-risk, potentially high-payoff projects at the forefront of science and technology. The LDRD Program at Livermore serves to: (1) Support the Laboratory's missions, strategic plan, and foundational science; (2) Maintain the Laboratory's science and technology vitality; (3) Promote recruiting and retention; (4) Pursue collaborations; (5) Generate intellectual property; and (6) Strengthen the U.S. economy. Myriad LDRD projects over the years have made important contributions to every facet of the Laboratory's mission and strategic plan, including its commitment to nuclear, global, and energy and environmental security, as well as cutting-edge science and technology and engineering in high-energy-density matter, high-performance computing and simulation, materials and chemistry at the extremes, information systems, measurements and experimental science, and energy manipulation. A summary of each project was submitted by the principal investigator. Project summaries include the scope, motivation, goals, relevance to DOE/NNSA and LLNL mission areas, the technical progress achieved in FY11, and a list of publications that resulted from the research. The projects are: (1) Nuclear Threat Reduction; (2) Biosecurity; (3) High-Performance Computing and Simulation; (4) Intelligence; (5) Cybersecurity; (6) Energy Security; (7) Carbon Capture; (8) Material Properties, Theory, and Design; (9) Radiochemistry; (10) High

  19. Idaho national laboratory - a nuclear research center

    International Nuclear Information System (INIS)

    Zaidi Mohammed, K.

    2006-01-01

    Full text: The Idaho National Laboratory (INL) is committed to providing international nuclear leadership for the 21st Century, developing and demonstrating compelling national security technologies, and delivering excellence in science and technology as one of the United States Department of Energy's (DOE) multi program national laboratories. INL runs three major programs - Nuclear, Security and Science. Nuclear programs covers the Advanced test reactor, Six Generation IV technology concepts selected for Rand D, targeting tumors - Boron Neutron Capture therapy. Homeland Security establishes the Control System Security and Test Center, Critical Infrastructure Test Range evaluates technologies on a scalable basis, INL conducts high performance computing and visualization research and science. To provide leadership in the education and training, INL has established an Institute of Nuclear Science and Engineering (INSE) under the Center for Advanced Energy Studies (CAES) and the Idaho State University (ISU). INSE will offer a four year degree based on a newly developed curriculum - two year of basic science course work and two years of participation in project planning and development. The students enrolled in this program can continue to get a masters or a doctoral degree. This summer INSE is the host for the training of the first international group selected by the World Nuclear University (WNU) - 75 fellowship holders and their 30 instructors from 40 countries. INL has been assigned to provide future global leadership in the field of nuclear science and technology. Here, at INL, we keep safety first above all things and our logo is 'Nuclear leadership synonymous with safety leadership'. (author)

  20. Laboratory directed research and development program FY 1997

    International Nuclear Information System (INIS)

    1998-03-01

    This report compiles the annual reports of Laboratory Directed Research and Development projects supported by the Berkeley Lab. Projects are arranged under the following topical sections: (1) Accelerator and fusion research division; (2) Chemical sciences division; (3) Computing Sciences; (4) Earth sciences division; (5) Environmental energy technologies division; (6) life sciences division; (7) Materials sciences division; (8) Nuclear science division; (9) Physics division; (10) Structural biology division; and (11) Cross-divisional. A total of 66 projects are summarized

  1. Laboratory directed research and development program FY 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    This report compiles the annual reports of Laboratory Directed Research and Development projects supported by the Berkeley Lab. Projects are arranged under the following topical sections: (1) Accelerator and fusion research division; (2) Chemical sciences division; (3) Computing Sciences; (4) Earth sciences division; (5) Environmental energy technologies division; (6) life sciences division; (7) Materials sciences division; (8) Nuclear science division; (9) Physics division; (10) Structural biology division; and (11) Cross-divisional. A total of 66 projects are summarized.

  2. Development of a Research-Oriented Inorganic Chemistry Laboratory Course

    Science.gov (United States)

    Vallarino, L. M.; Polo, D. L.; Esperdy, K.

    2001-02-01

    We report the development of a research-oriented, senior-level laboratory course in inorganic chemistry, which is a requirement for chemistry majors who plan to receive the ACS-approved Bachelor of Science degree and is a recommended elective for other chemistry majors. The objective of this course is to give all students the advantage of a research experience in which questions stemming from the literature lead to the formulation of hypotheses, and answers are sought through experiment. The one-semester Inorganic Chemistry Laboratory is ideal for this purpose, since for most students it represents the last laboratory experience before graduation and can assume the role of "capstone" course--a course where students are challenged to recall previously learned concepts and skills and put them into practice in the performance of an individual, original research project. The medium chosen for this teaching approach is coordination chemistry, a branch of chemistry that involves the interaction of inorganic and organic compounds and requires the use of various synthetic and analytical methods. This paper presents an outline of the course organization and requirements, examples of activities performed by the students, and a critical evaluation of the first five years' experience.

  3. Development and Evaluation of an Interactive Electronic Laboratory Manual for Cooperative Learning of Medical Histology

    Science.gov (United States)

    Khalil, Mohammed K.; Kirkley, Debbie L.; Kibble, Jonathan D.

    2013-01-01

    This article describes the development of an interactive computer-based laboratory manual, created to facilitate the teaching and learning of medical histology. The overarching goal of developing the manual is to facilitate self-directed group interactivities that actively engage students during laboratory sessions. The design of the manual…

  4. Laboratory services series: a safety program for service groups in a national research and development laboratory (1965--1974)

    International Nuclear Information System (INIS)

    Winget, R.H.

    1975-11-01

    The experiences of a ten-year period of developing a safety program for craft and labor groups supporting a major laboratory are summarized with tabulations of types of injuries or accidents, improvements noted over the decade, and educational and safety recognition efforts

  5. A Newly Developed Method for Computing Reliability Measures in a Water Supply Network

    Directory of Open Access Journals (Sweden)

    Jacek Malinowski

    2016-01-01

    Full Text Available A reliability model of a water supply network has beens examined. Its main features are: a topology that can be decomposed by the so-called state factorization into a (relativelysmall number of derivative networks, each having a series-parallel structure (1, binary-state components (either operative or failed with given flow capacities (2, a multi-state character of the whole network and its sub-networks - a network state is defined as the maximal flow between a source (sources and a sink (sinks (3, all capacities (component, network, and sub-network have integer values (4. As the network operates, its state changes due to component failures, repairs, and replacements. A newly developed method of computing the inter-state transition intensities has been presented. It is based on the so-called state factorization and series-parallel aggregation. The analysis of these intensities shows that the failure-repair process of the considered system is an asymptotically homogenous Markov process. It is also demonstrated how certain reliability parameters useful for the network maintenance planning can be determined on the basis of the asymptotic intensities. For better understanding of the presented method, an illustrative example is given. (original abstract

  6. LBNL Laboratory Directed Research and Development Program FY2016

    Energy Technology Data Exchange (ETDEWEB)

    Ho, D.

    2017-03-01

    The Berkeley Lab Laboratory Directed Research and Development Program FY2016 report is compiled from annual reports submitted by principal investigators following the close of the fiscal year. This report describes the supported projects and summarizes their accomplishments. It constitutes a part of the LDRD program planning and documentation process that includes an annual planning cycle, project selection, implementation and review.

  7. Laboratory directed research and development. FY 1995 progress report

    Energy Technology Data Exchange (ETDEWEB)

    Vigil, J.; Prono, J. [comps.

    1996-03-01

    This document presents an overview of Laboratory Directed Research and Development Programs at Los Alamos. The nine technical disciplines in which research is described include materials, engineering and base technologies, plasma, fluids, and particle beams, chemistry, mathematics and computational science, atmic and molecular physics, geoscience, space science, and astrophysics, nuclear and particle physics, and biosciences. Brief descriptions are provided in the above programs.

  8. Generational differences among newly licensed registered nurses.

    Science.gov (United States)

    Keepnews, David M; Brewer, Carol S; Kovner, Christine T; Shin, Juh Hyun

    2010-01-01

    Responses of 2369 newly licensed registered nurses from 3 generational cohorts-Baby Boomers, Generation X, and Generation Y-were studied to identify differences in their characteristics, work-related experiences, and attitudes. These responses revealed significant differences among generations in: job satisfaction, organizational commitment, work motivation, work-to-family conflict, family-to-work conflict, distributive justice, promotional opportunities, supervisory support, mentor support, procedural justice, and perceptions of local job opportunities. Health organizations and their leaders need to anticipate intergenerational differences among newly licensed nurses and should provide for supportive working environments that recognize those differences. Orientation and residency programs for newly licensed nurses should be tailored to the varying needs of different generations. Future research should focus on evaluating the effectiveness of orientation and residency programs with regard to different generations so that these programs can be tailored to meet the varying needs of newly licensed nurses at the start of their careers. Copyright 2010 Mosby, Inc. All rights reserved.

  9. Transforming the Learning Environment of Undergraduate Physics Laboratories to Enhance Physics Inquiry Processes

    Directory of Open Access Journals (Sweden)

    Gregory P. Thomas

    2017-04-01

    Full Text Available Concerns persist regarding the lack of promotion of students’ scientific inquiry processes in undergraduate physics laboratories. The consensus in the literature is that, especially in the early years of undergraduate physics programs, students’ laboratory work is characterized by recipe type, step-by-step instructions for activities where the aim is often confirmation of an already well-established physics principle or concept. In response to evidence reflecting these concerns at their university, the authors successfully secured funding for this study. A mixed-method design was employed. In the 2011/2012 academic year baseline data were collected. A quantitative survey, the Undergraduate Physics Laboratory Learning Environment Scale (UPLLES was developed, validated, and used to explore students’ perceptions of their physics laboratory environments. Analysis of data from the UPLLES and from interviews confirmed the concerns evident in the literature and in a previous evaluation of laboratories undertaken in 2002. To address these concerns the activities that students were to perform in the laboratory section of the course/s were re/designed to engage students in more inquiry oriented thinking and activity. In Fall 2012, the newly developed laboratory activities and tutorials, were implemented for the first time in PHYS124; a first year course. These changes were accompanied by structured training of teaching assistants and changes to the structure of the evaluation of students’ laboratory performance. At the end of that term the UPLLES was administered (n = 266 and interviews with students conducted (n = 16 to explore their perceptions of their laboratory environments. Statistically significant differences (p<.001 between the students in the PHYS 124 classes of 2011/2012 and 2012/2013 across all dimensions were found. Effect sizes of 0.82 to 1.3, between the views of students in the first semester physics classes of 2011/2012 and 2012

  10. Laboratory-directed research and development: FY 1996 progress report

    Energy Technology Data Exchange (ETDEWEB)

    Vigil, J.; Prono, J. [comps.

    1997-05-01

    This report summarizes the FY 1996 goals and accomplishments of Laboratory-Directed Research and Development (LDRD) projects. It gives an overview of the LDRD program, summarizes work done on individual research projects, and provides an index to the projects` principal investigators. Projects are grouped by their LDRD component: Individual Projects, Competency Development, and Program Development. Within each component, they are further divided into nine technical disciplines: (1) materials science, (2) engineering and base technologies, (3) plasmas, fluids, and particle beams, (4) chemistry, (5) mathematics and computational sciences, (6) atomic and molecular physics, (7) geoscience, space science, and astrophysics, (8) nuclear and particle physics, and (9) biosciences.

  11. Laboratory-directed research and development: FY 1996 progress report

    International Nuclear Information System (INIS)

    Vigil, J.; Prono, J.

    1997-05-01

    This report summarizes the FY 1996 goals and accomplishments of Laboratory-Directed Research and Development (LDRD) projects. It gives an overview of the LDRD program, summarizes work done on individual research projects, and provides an index to the projects' principal investigators. Projects are grouped by their LDRD component: Individual Projects, Competency Development, and Program Development. Within each component, they are further divided into nine technical disciplines: (1) materials science, (2) engineering and base technologies, (3) plasmas, fluids, and particle beams, (4) chemistry, (5) mathematics and computational sciences, (6) atomic and molecular physics, (7) geoscience, space science, and astrophysics, (8) nuclear and particle physics, and (9) biosciences

  12. Firing Room Remote Application Software Development & Swamp Works Laboratory Robot Software Development

    Science.gov (United States)

    Garcia, Janette

    2016-01-01

    The National Aeronautics and Space Administration (NASA) is creating a way to send humans beyond low Earth orbit, and later to Mars. Kennedy Space Center (KSC) is working to make this possible by developing a Spaceport Command and Control System (SCCS) which will allow the launch of Space Launch System (SLS). This paper's focus is on the work performed by the author in her first and second part of the internship as a remote application software developer. During the first part of her internship, the author worked on the SCCS's software application layer by assisting multiple ground subsystems teams including Launch Accessories (LACC) and Environmental Control System (ECS) on the design, development, integration, and testing of remote control software applications. Then, on the second part of the internship, the author worked on the development of robot software at the Swamp Works Laboratory which is a research and technology development group which focuses on inventing new technology to help future In-Situ Resource Utilization (ISRU) missions.

  13. Mentorship for newly appointed physicians: a strategy for enhancing patient safety?

    Science.gov (United States)

    Harrison, Reema; McClean, Serwaa; Lawton, Rebecca; Wright, John; Kay, Clive

    2014-09-01

    Mentorship is an increasingly popular innovation from business and industry that is being applied in health-care contexts. This paper explores the concept of mentorship for newly appointed physicians in their first substantive senior post, and specifically its utilization to enhance patient safety. Semi-structured face to face and telephone interviews with Medical Directors (n = 5), Deputy Medical Directors (n = 4), and Clinical Directors (n = 6) from 9 acute NHS Trusts in the Yorkshire and Humber region in the north of England. A focused thematic analysis was used. A number of beneficial outcomes were associated with mentorship for newly appointed physicians including greater personal and professional support, organizational commitment, and general well-being. Providing newly appointed senior physicians with support through mentorship was considered to enhance the safety of patient care. Mentorship may prevent or reduce active failures, be used to identify threats in the local working environment, and in the longer term, address latent threats to safety within the organization by encouraging a healthier safety culture. Offering mentorship to all newly appointed physicians in their first substantive post in health care may be a useful strategy to support the development of their clinical, professional, and personal skills in this transitional period that may also enhance the safety of patient care.

  14. Subclassification of newly diagnosed glioblastomas through an immunohistochemical approach.

    Directory of Open Access Journals (Sweden)

    Siobhan Conroy

    Full Text Available Molecular signatures in Glioblastoma (GBM have been described that correlate with clinical outcome and response to therapy. The Proneural (PN and Mesenchymal (MES signatures have been identified most consistently, but others including Classical (CLAS have also been reported. The molecular signatures have been detected by array techniques at RNA and DNA level, but these methods are costly and cannot take into account individual contributions of different cells within a tumor. Therefore, the aim of this study was to investigate whether subclasses of newly diagnosed GBMs could be assessed and assigned by application of standard pathology laboratory procedures. 123 newly diagnosed GBMs were analyzed for the tumor cell expression of 23 pre-identified proteins and EGFR amplification, together allowing for the subclassification of 65% of the tumors. Immunohistochemistry (IHC-based profiling was found to be analogous to transcription-based profiling using a 9-gene transcriptional signature for PN and MES subclasses. Based on these data a novel, minimal IHC-based scheme for subclass assignment for GBMs is proposed. Positive staining for IDH1R132H can be used for PN subclass assignment, high EGFR expression for the CLAS subtype and a combined high expression of PTEN, VIM and/or YKL40 for the MES subclass. The application of the proposed scheme was evaluated in an independent tumor set, which resulted in similar subclass assignment rates as those observed in the training set. The IHC-based subclassification scheme proposed in this study therefore could provide very useful in future studies for stratification of individual patient samples.

  15. Chemistry {ampersand} Materials Science program report, Weapons Resarch and Development and Laboratory Directed Research and Development FY96

    Energy Technology Data Exchange (ETDEWEB)

    Chase, L.

    1997-03-01

    This report is the annual progress report for the Chemistry Materials Science Program: Weapons Research and Development and Laboratory Directed Research and Development. Twenty-one projects are described separately by their principal investigators.

  16. Development of a Portable Motor Learning Laboratory (PoMLab).

    Science.gov (United States)

    Takiyama, Ken; Shinya, Masahiro

    2016-01-01

    Most motor learning experiments have been conducted in a laboratory setting. In this type of setting, a huge and expensive manipulandum is frequently used, requiring a large budget and wide open space. Subjects also need to travel to the laboratory, which is a burden for them. This burden is particularly severe for patients with neurological disorders. Here, we describe the development of a novel application based on Unity3D and smart devices, e.g., smartphones or tablet devices, that can be used to conduct motor learning experiments at any time and in any place, without requiring a large budget and wide open space and without the burden of travel on subjects. We refer to our application as POrtable Motor learning LABoratory, or PoMLab. PoMLab is a multiplatform application that is available and sharable for free. We investigated whether PoMLab could be an alternative to the laboratory setting using a visuomotor rotation paradigm that causes sensory prediction error, enabling the investigation of how subjects minimize the error. In the first experiment, subjects could adapt to a constant visuomotor rotation that was abruptly applied at a specific trial. The learning curve for the first experiment could be modeled well using a state space model, a mathematical model that describes the motor leaning process. In the second experiment, subjects could adapt to a visuomotor rotation that gradually increased each trial. The subjects adapted to the gradually increasing visuomotor rotation without being aware of the visuomotor rotation. These experimental results have been reported for conventional experiments conducted in a laboratory setting, and our PoMLab application could reproduce these results. PoMLab can thus be considered an alternative to the laboratory setting. We also conducted follow-up experiments in university physical education classes. A state space model that was fit to the data obtained in the laboratory experiments could predict the learning curves

  17. Development of a Portable Motor Learning Laboratory (PoMLab.

    Directory of Open Access Journals (Sweden)

    Ken Takiyama

    Full Text Available Most motor learning experiments have been conducted in a laboratory setting. In this type of setting, a huge and expensive manipulandum is frequently used, requiring a large budget and wide open space. Subjects also need to travel to the laboratory, which is a burden for them. This burden is particularly severe for patients with neurological disorders. Here, we describe the development of a novel application based on Unity3D and smart devices, e.g., smartphones or tablet devices, that can be used to conduct motor learning experiments at any time and in any place, without requiring a large budget and wide open space and without the burden of travel on subjects. We refer to our application as POrtable Motor learning LABoratory, or PoMLab. PoMLab is a multiplatform application that is available and sharable for free. We investigated whether PoMLab could be an alternative to the laboratory setting using a visuomotor rotation paradigm that causes sensory prediction error, enabling the investigation of how subjects minimize the error. In the first experiment, subjects could adapt to a constant visuomotor rotation that was abruptly applied at a specific trial. The learning curve for the first experiment could be modeled well using a state space model, a mathematical model that describes the motor leaning process. In the second experiment, subjects could adapt to a visuomotor rotation that gradually increased each trial. The subjects adapted to the gradually increasing visuomotor rotation without being aware of the visuomotor rotation. These experimental results have been reported for conventional experiments conducted in a laboratory setting, and our PoMLab application could reproduce these results. PoMLab can thus be considered an alternative to the laboratory setting. We also conducted follow-up experiments in university physical education classes. A state space model that was fit to the data obtained in the laboratory experiments could predict the

  18. LDRD 2012 Annual Report: Laboratory Directed Research and Development Program Activities

    Energy Technology Data Exchange (ETDEWEB)

    Bookless, William [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2012-12-31

    Each year, Brookhaven National Laboratory (BNL) is required to provide a program description and overview of its Laboratory Directed Research and Development Program (LDRD) to the Department of Energy in accordance with DOE Order 413.2B dated April 19, 2006. This report provides a detailed look at the scientific and technical activities for each of the LDRD projects funded by BNL in FY2012, as required. In FY2012, the BNL LDRD Program funded 52 projects, 14 of which were new starts, at a total cost of $10,061,292.

  19. LDRD 2014 Annual Report: Laboratory Directed Research and Development Program Activities

    Energy Technology Data Exchange (ETDEWEB)

    Hatton, Diane [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-03-01

    Each year, Brookhaven National Laboratory (BNL) is required to provide a program description and overview of its Laboratory Directed Research and Development Program (LDRD) to the Department of Energy (DOE) in accordance with DOE Order 413.2B dated April 19, 2006. This report provides a detailed look at the scientific and technical activities for each of the LDRD projects funded by BNL in FY 2014, as required. In FY 2014, the BNL LDRD Program funded 40 projects, 8 of which were new starts, at a total cost of $9.6M.

  20. LDRD 2015 Annual Report: Laboratory Directed Research and Development Program Activities

    Energy Technology Data Exchange (ETDEWEB)

    Hatton, D. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-12-31

    Each year, Brookhaven National Laboratory (BNL) is required to provide a program description and overview of its Laboratory Directed Research and Development Program (LDRD) to the Department of Energy (DOE) in accordance with DOE Order 413.2B dated April 19, 2006. This report provides a detailed look at the scientific and technical activities for each of the LDRD projects funded by BNL in FY 2015, as required. In FY 2015, the BNL LDRD Program funded 43 projects, 12 of which were new starts, at a total cost of $9.5M.

  1. Laboratory Directed Research & Development Program. Annual report to the Department of Energy, Revised December 1993

    Energy Technology Data Exchange (ETDEWEB)

    Ogeka, G.J.; Romano, A.J.

    1993-12-01

    At Brookhaven National Laboratory the Laboratory Directed Research and Development (LDRD) Program is a discretionary research and development tool critical in maintaining the scientific excellence and vitality of the laboratory. It is also a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor in achieving and maintaining staff excellence, and a means to address national needs, within the overall mission of the Department of Energy and Brookhaven National Laboratory. This report summarizes research which was funded by this program during fiscal year 1993. The research fell in a number of broad technical and scientific categories: new directions for energy technologies; global change; radiation therapies and imaging; genetic studies; new directions for the development and utilization of BNL facilities; miscellaneous projects. Two million dollars in funding supported 28 projects which were spread throughout all BNL scientific departments.

  2. [An Introduction to A Newly-developed "Acupuncture Needle Manipulation Training-evaluation System" Based on Optical Motion Capture Technique].

    Science.gov (United States)

    Zhang, Ao; Yan, Xing-Ke; Liu, An-Guo

    2016-12-25

    In the present paper, the authors introduce a newly-developed "Acupuncture Needle Manipulation Training-evaluation System" based on optical motion capture technique. It is composed of two parts, sensor and software, and overcomes some shortages of mechanical motion capture technique. This device is able to analyze the data of operations of the pressing-hand and needle-insertion hand during acupuncture performance and its software contains personal computer (PC) version, Android version, and Internetwork Operating System (IOS) Apple version. It is competent in recording and analyzing information of any ope-rator's needling manipulations, and is quite helpful for teachers in teaching, training and examining students in clinical practice.

  3. Development of space simulation / net-laboratory system

    Science.gov (United States)

    Usui, H.; Matsumoto, H.; Ogino, T.; Fujimoto, M.; Omura, Y.; Okada, M.; Ueda, H. O.; Murata, T.; Kamide, Y.; Shinagawa, H.; Watanabe, S.; Machida, S.; Hada, T.

    A research project for the development of space simulation / net-laboratory system was approved by Japan Science and Technology Corporation (JST) in the category of Research and Development for Applying Advanced Computational Science and Technology(ACT-JST) in 2000. This research project, which continues for three years, is a collaboration with an astrophysical simulation group as well as other space simulation groups which use MHD and hybrid models. In this project, we develop a proto type of unique simulation system which enables us to perform simulation runs by providing or selecting plasma parameters through Web-based interface on the internet. We are also developing an on-line database system for space simulation from which we will be able to search and extract various information such as simulation method and program, manuals, and typical simulation results in graphic or ascii format. This unique system will help the simulation beginners to start simulation study without much difficulty or effort, and contribute to the promotion of simulation studies in the STP field. In this presentation, we will report the overview and the current status of the project.

  4. NRAO Central Development Laboratory (CDL)

    Data.gov (United States)

    Federal Laboratory Consortium — The mission of the CDL is to support the evolution of NRAO's existing facilities and to provide the technology and expertise needed to build the next generation of...

  5. Recent developments in the target facilities at Argonne National Laboratory

    International Nuclear Information System (INIS)

    Greene, J.P.; Thomas, G.E.

    1989-01-01

    A description is given of recent developments in the target facility at Argonne National Laboratory (ANL). Highlights include equipment upgrades which enable us to provide enhanced capabilities for support of the Argonne Heavy-Ion ATLAS Accelerator Project. Also, future plans and additional equipment acquisitions will be discussed. (orig.)

  6. Laboratory Directed Research and Development Program FY2004

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Todd C.

    2005-03-22

    The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab or LBNL) is a multi-program national research facility operated by the University of California for the Department of Energy (DOE). As an integral element of DOE's National Laboratory System, Berkeley Lab supports DOE's missions in fundamental science, energy resources, and environmental quality. Berkeley Lab programs advance four distinct goals for DOE and the nation: (1) To perform leading multidisciplinary research in the computing sciences, physical sciences, energy sciences, biosciences, and general sciences in a manner that ensures employee and public safety and protection of the environment. (2) To develop and operate unique national experimental facilities for qualified investigators. (3) To educate and train future generations of scientists and engineers to promote national science and education goals. (4) To transfer knowledge and technological innovations and to foster productive relationships among Berkeley Lab's research programs, universities, and industry in order to promote national economic competitiveness. Berkeley Lab's research and the Laboratory Directed Research and Development (LDRD) program support DOE's Strategic Goals that are codified in DOE's September 2003 Strategic Plan, with a primary focus on Advancing Scientific Understanding. For that goal, the Fiscal Year (FY) 2004 LDRD projects support every one of the eight strategies described in the plan. In addition, LDRD efforts support the goals of Investing in America's Energy Future (six of the fourteen strategies), Resolving the Environmental Legacy (four of the eight strategies), and Meeting National Security Challenges (unclassified fundamental research that supports stockpile safety and nonproliferation programs). The LDRD supports Office of Science strategic plans, including the 20 year Scientific Facilities Plan and the draft Office of Science Strategic Plan. The research also

  7. The effect of strain distribution on microstructural developments during forging in a newly developed nickel base superalloy

    Energy Technology Data Exchange (ETDEWEB)

    Buckingham, R.C. [Institute of Structural Materials, Swansea University, Bay Campus, Fabian Way, Swansea SA1 8EN (United Kingdom); Argyrakis, C.; Hardy, M.C. [Rolls-Royce plc, PO Box 31, Derby DE24 8BJ (United Kingdom); Birosca, S., E-mail: 522042@swansea.ac.uk [Institute of Structural Materials, Swansea University, Bay Campus, Fabian Way, Swansea SA1 8EN (United Kingdom)

    2016-01-27

    In the current study, the effect of strain distribution in a simple forging geometry on the propensity for recrystallization, and its impact on mechanical properties has been investigated in a newly developed experimental nickel-based superalloy. The new alloy was produced via a Powder Metallurgy (PM) route and was subsequently Hot Isostatic Processed (HIP), isothermally forged, and heat treated to produce a coarse grain microstructure with average grain size of 23–32 μm. The alloy was examined by means of Electron Back-Scatter Diffraction (EBSD) to characterise the microstructural features such as grain orientation and morphology, grain boundary characteristics and the identification of potential Prior Particle Boundaries (PPBs) throughout each stage of the processing route. Results at the central region of the cross-section plane parallel to the loading direction showed significant microstructural differences across the forging depth. This microstructural variation was found to be highly dependent on the value of local strain imparted during forging such that areas of low effective strain showed partial recrystallisation and a necklace grain structure was observed following heat treatment. Meanwhile, a fully recrystallised microstructure with no PPBs was observed in the areas of high strain values, in the central region of the forging.

  8. DTU PMU Laboratory Development - Testing and Validation

    DEFF Research Database (Denmark)

    Garcia-Valle, Rodrigo; Yang, Guang-Ya; Martin, Kenneth E.

    2010-01-01

    This is a report of the results of phasor measurement unit (PMU) laboratory development and testing done at the Centre for Electric Technology (CET), Technical University of Denmark (DTU). Analysis of the PMU performance first required the development of tools to convert the DTU PMU data into IEEE...... standard, and the validation is done for the DTU-PMU via a validated commercial PMU. The commercial PMU has been tested from the authors' previous efforts, where the response can be expected to follow known patterns and provide confirmation about the test system to confirm the design and settings....... In a nutshell, having 2 PMUs that observe same signals provides validation of the operation and flags questionable results with more certainty. Moreover, the performance and accuracy of the DTU-PMU is tested acquiring good and precise results, when compared with a commercial phasor measurement device, PMU-1....

  9. Guidelines for developing certification programs for newly generated TRU waste

    International Nuclear Information System (INIS)

    Whitty, W.J.; Ostenak, C.A.; Pillay, K.K.S.; Geoffrion, R.R.

    1983-05-01

    These guidelines were prepared with direction from the US Department of Energy (DOE) Transuranic (TRU) Waste Management Program in support of the DOE effort to certify that newly generated TRU wastes meet the Waste Isolation Pilot Plant (WIPP) Waste Acceptance Criteria. The guidelines provide instructions for generic Certification Program preparation for TRU-waste generators preparing site-specific Certification Programs in response to WIPP requirements. The guidelines address all major aspects of a Certification Program that are necessary to satisfy the WIPP Waste Acceptance Criteria and their associated Compliance Requirements and Certification Quality Assurance Requirements. The details of the major element of a Certification Program, namely, the Certification Plan, are described. The Certification Plan relies on supporting data and control documentation to provide a traceable, auditable account of certification activities. Examples of specific parts of the Certification Plan illustrate the recommended degree of detail. Also, a brief description of generic waste processes related to certification activities is included

  10. Newly democratic Mongolia offering exploration contracts

    International Nuclear Information System (INIS)

    Penttila, W.C.

    1992-01-01

    This paper reports that Mongolia, formerly the Mongolian People's Republic, is working to open its exploration prospects to international operators as it emerges as the world's 15th largest independent nation. The country, about the same size as Alaska with a population of 2 million, held its first free election in July 1990. The newly elected government drafted a constitution that took effect Feb. 12, 1992. The document modifies the previous government's structures to eliminate bureaucracy and allows for political pluralism. At the same time, the government is formulating energy policies, state oil company structure, and resource development philosophy

  11. Development of laboratory acceleration test method for service life prediction of concrete structures

    International Nuclear Information System (INIS)

    Cho, M. S.; Song, Y. C.; Bang, K. S.; Lee, J. S.; Kim, D. K.

    1999-01-01

    Service life prediction of nuclear power plants depends on the application of history of structures, field inspection and test, the development of laboratory acceleration tests, their analysis method and predictive model. In this study, laboratory acceleration test method for service life prediction of concrete structures and application of experimental test results are introduced. This study is concerned with environmental condition of concrete structures and is to develop the acceleration test method for durability factors of concrete structures e.g. carbonation, sulfate attack, freeze-thaw cycles and shrinkage-expansion etc

  12. Laboratory Tests in the Development of WaveCat

    Directory of Open Access Journals (Sweden)

    James Allen

    2016-12-01

    Full Text Available WaveCat, a novel overtopping Wave Energy Converter, was tested with the aim of determining its performance under different sea states, establishing a starting point for optimisation of the device, numerical model validation and proof-of-concept for the control systems. The tests were carried out at a 1:30 scale in the Ocean Basin of the COAST Laboratory at University of Plymouth. A state-of-the-art control system was implemented, and overtopping rates and device motions were recorded alongside the wave field. It was observed that power generation is dependent on both the wave height and period, with smaller periods tending to produce greater overtopping rates, and therefore greater power generation, for the same wave height. Due to time constraints in the laboratory, only one configuration of draft/freeboard was tested; with this configuration, overtopping occurred under significant wave heights of 0.083 m or more, corresponding to 2.5 m or more in prototype values. These experimental results form the basis for future development and optimisation of WaveCat.

  13. Latest developments at the ALBA magnetic measurements laboratory

    Science.gov (United States)

    Marcos, J.; Massana, V.; García, L.; Campmany, J.

    2018-02-01

    ALBA is a third-generation synchrotron light source that has been in operation since 2012 near Barcelona. A magnetic measurements laboratory has been associated with the facility since its very early stages and has been active for the last 20 years. In the first part of this work, the different instruments available at the laboratory are described, and a brief overview of the measurement campaigns carried out during its 20 years of history is presented. In the second part, a more detailed description of the approach to Hall probe measurements adopted at ALBA is offered, with an explanation of the methods and ancillary equipment that have been developed along the years in order to improve the accuracy of the system. In the third part, a new concept of Hall probe bench devoted to the measurement of closed structures is presented. The in-house design and building of a prototype for such a bench is described, together with its mechanical and magnetic characterization. As a conclusion, the first results obtained with this bench are discussed.

  14. Materials and process engineering projects for the Sandia National Laboratories/Newly Independent States Industrial Partnering Program. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Zanner, F.J.; Moffatt, W.C.

    1995-07-01

    In July, 1994, a team of materials specialists from Sandia and U S Industry traveled to Russia and the Ukraine to select and fund projects in materials and process technology in support of the Newly Independent States/Industrial Partnering Program (NIS/IPP). All of the projects are collaborations with scientists and Engineers at NIS Institutes. Each project is scheduled to last one year, and the deliverables are formatted to supply US Industry with information which will enable rational decisions to be made regarding the commercial value of these technologies. This work is an unedited interim compilation of the deliverables received to date.

  15. Materials and process engineering projects for the Sandia National Laboratories/Newly Independent States Industrial Partnering Program. Volume 2

    International Nuclear Information System (INIS)

    Zanner, F.J.; Moffatt, W.C.

    1995-07-01

    In July, 1994, a team of materials specialists from Sandia and US. Industry traveled to Russia and the Ukraine to select and fund projects in materials and process technology in support of the Newly Independent States/Industrial Partnering Program (NIS/IPP). All of the projects are collaborations with scientists and Engineers at NIS Institutes. Each project is scheduled to last one year, and the deliverables are formatted to supply US. Industry with information which will enable rational decisions to be made regarding the commercial value of these technologies. This work is an unedited interim compilation of the deliverables received to date

  16. Materials and process engineering projects for the Sandia National Laboratories/Newly Independent States Industrial Partnering Program. Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    Zanner, F.J.; Moffatt, W.C.

    1995-07-01

    In July, 1994, a team of materials specialists from Sandia and US. Industry traveled to Russia and the Ukraine to select and fund projects in materials and process technology in support of the Newly Independent States/Industrial Partnering Program (NIS/IPP). All of the projects are collaborations with scientists and Engineers at NIS Institutes. Each project is scheduled to last one year, and the deliverables are formatted to supply US. Industry with information which will enable rational decisions to be made regarding the commercial value of these technologies. This work is an unedited interim compilation of the deliverables received to date.

  17. Comparison of a newly developed binary typing with ribotyping and multilocus sequence typing methods for Clostridium difficile.

    Science.gov (United States)

    Li, Zhirong; Liu, Xiaolei; Zhao, Jianhong; Xu, Kaiyue; Tian, Tiantian; Yang, Jing; Qiang, Cuixin; Shi, Dongyan; Wei, Honglian; Sun, Suju; Cui, Qingqing; Li, Ruxin; Niu, Yanan; Huang, Bixing

    2018-04-01

    Clostridium difficile is the causative pathogen for antibiotic-related nosocomial diarrhea. For epidemiological study and identification of virulent clones, a new binary typing method was developed for C. difficile in this study. The usefulness of this newly developed optimized 10-loci binary typing method was compared with two widely used methods ribotyping and multilocus sequence typing (MLST) in 189 C. difficile samples. The binary typing, ribotyping and MLST typed the samples into 53 binary types (BTs), 26 ribotypes (RTs), and 33 MLST sequence types (STs), respectively. The typing ability of the binary method was better than that of either ribotyping or MLST expressed in Simpson Index (SI) at 0.937, 0.892 and 0.859, respectively. The ease of testing, portability and cost-effectiveness of the new binary typing would make it a useful typing alternative for outbreak investigations within healthcare facilities and epidemiological research. Copyright © 2018 Elsevier B.V. All rights reserved.

  18. Who Is Doing Well? A Typology of Newly Homeless Adolescents

    Science.gov (United States)

    Milburn, Norweeta; Liang, Li-Jung; Lee, Sung-Jae; Rotheram-Borus, Mary Jane; Rosenthal, Doreen; Mallett, Shelley; Lightfoot, Marguerita; Lester, Patricia

    2009-01-01

    There is growing evidence to support developing new typologies for homeless adolescents. Current typologies focus on the risks associated with being homeless, with less consideration of the positive attributes of homeless adolescents. The authors examined both risk and protective factors in a sample of newly homeless adolescents. Using cluster…

  19. 1997 Laboratory directed research and development. Annual report

    Energy Technology Data Exchange (ETDEWEB)

    Meyers, C.E.; Harvey, C.L.; Chavez, D.L.; Whiddon, C.P. [comps.

    1997-12-31

    This report summarizes progress from the Laboratory Directed Research and Development (LDRD) program during fiscal year 1997. In addition to a programmatic and financial overview, the report includes progress reports from 218 individual R&D projects in eleven categories. Theses reports are grouped into the following areas: materials science and technology; computer sciences; electronics and photonics; phenomenological modeling and engineering simulation; manufacturing science and technology; life-cycle systems engineering; information systems; precision sensing and analysis; environmental sciences; risk and reliability; national grand challenges; focused technologies; and reserve.

  20. Development and Evaluation of Computer-Based Laboratory Practical Learning Tool

    Science.gov (United States)

    Gandole, Y. B.

    2006-01-01

    Effective evaluation of educational software is a key issue for successful introduction of advanced tools in the curriculum. This paper details to developing and evaluating a tool for computer assisted learning of science laboratory courses. The process was based on the generic instructional system design model. Various categories of educational…

  1. Recent developments in the target facilities at Argonne National Laboratory

    International Nuclear Information System (INIS)

    Greene, J.P.; Thomas, G.E.

    1988-01-01

    A description is given of recent developments in the target facility at Argonne National Laboratory. Highlights include equipment upgrades which enables us to provide enhanced capabilities for support of the Argonne Heavy-Ion ATLAS Accelerator Project. Also future plans and additional equipment acquisitions will be discussed. 3 refs., 3 tabs

  2. NNSA Laboratory Directed Research and Development Program 2008 Symposium--Focus on Energy Security

    Energy Technology Data Exchange (ETDEWEB)

    Kotta, P R; Sketchley, J A

    2008-08-20

    The Laboratory Directed Research and Development (LDRD) Program was authorized by Congress in 1991 to fund leading-edge research and development central to the national laboratories core missions. LDRD anticipates and engages in projects on the forefront of science and engineering at the Department of Energy (DOE) national laboratories, and has a long history of addressing pressing national security needs at the National Nuclear Security Administration (NNSA) laboratories. LDRD has been a scientific success story, where projects continue to win national recognition for excellence through prestigious awards, papers published and cited in peer-reviewed journals, mainstream media coverage, and patents granted. The LDRD Program is also a powerful means to attract and retain top researchers from around the world, to foster collaborations with other prominent scientific and technological institutions, and to leverage some of the world's most technologically advanced assets. This enables the LDRD Program to invest in high-risk and potentially high-payoff research that creates innovative technical solutions for some of our nation's most difficult challenges. Worldwide energy demand is growing at an alarming rate, as developing nations continue to expand their industrial and economic base on the back of limited global resources. The resulting international conflicts and environmental consequences pose serious challenges not only to this nation, but to the international community as well. The NNSA and its national security laboratories have been increasingly called upon to devote their scientific and technological capabilities to help address issues that are not limited solely to the historic nuclear weapons core mission, but are more expansive and encompass a spectrum of national security missions, including energy security. This year's symposium highlights some of the exciting areas of research in alternative fuels and technology, nuclear power, carbon

  3. FY2007 Laboratory Directed Research and Development Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Craig, W W; Sketchley, J A; Kotta, P R

    2008-03-20

    The Laboratory Directed Research and Development (LDRD) annual report for fiscal year 2007 (FY07) provides a summary of LDRD-funded projects for the fiscal year and consists of two parts: An introduction to the LDRD Program, the LDRD portfolio-management process, program statistics for the year, and highlights of accomplishments for the year. A summary of each project, submitted by the principal investigator. Project summaries include the scope, motivation, goals, relevance to Department of Energy (DOE)/National Nuclear Security Administration (NNSA) and Lawrence Livermore National Laboratory (LLNL) mission areas, the technical progress achieved in FY07, and a list of publications that resulted from the research in FY07. Summaries are organized in sections by research category (in alphabetical order). Within each research category, the projects are listed in order of their LDRD project category: Strategic Initiative (SI), Exploratory Research (ER), Laboratory-Wide Competition (LW), and Feasibility Study (FS). Within each project category, the individual project summaries appear in order of their project tracking code, a unique identifier that consists of three elements. The first is the fiscal year the project began, the second represents the project category, and the third identifies the serial number of the proposal for that fiscal year.

  4. Newly graduated nurses' empowerment regarding professional competence and other work-related factors.

    Science.gov (United States)

    Kuokkanen, Liisa; Leino-Kilpi, Helena; Numminen, Olivia; Isoaho, Hannu; Flinkman, Mervi; Meretoja, Riitta

    2016-01-01

    Although both nurse empowerment and competence are fundamental concepts of describing newly graduated nurses' professional development and job satisfaction, only few studies exist on the relationship between these concepts. Therefore, the purpose of this study was to determine how newly graduated nurses assess their empowerment and to clarify professional competence compared to other work-related factors. A descriptive, cross-sectional and correlational design was applied. The sample comprised newly graduated nurses (n = 318) in Finland. Empowerment was measured using the 19-item Qualities of an Empowered Nurse scale and the Nurse Competence Scale measured nurses' self-assessed generic competence. In addition to demographic data, the background data included employment sector (public/private), job satisfaction, intent to change/leave job, work schedule (shifts/business hours) and assessments of the quality of care in the workplace. The data were analysed statistically by using Spearman's correlation coefficient as well as the One-Way and Multivariate Analysis of Variance. Cronbach's alpha coefficient was used to estimate the internal consistency. Newly graduated nurses perceived their level of empowerment and competence fairly high. The association between nurse empowerment and professional competence was statistically significant. Other variables correlating positively to empowerment included employment sector, age, job satisfaction, intent to change job, work schedule, and satisfaction with the quality of care in the work unit. The study indicates competence had the strongest effect on newly graduated nurses' empowerment. New graduates need support and career opportunities. In the future, nurses' further education and nurse managers' resources for supporting and empowering nurses should respond to the newly graduated nurses' requisites for attractive and meaningful work.

  5. Use of a newly developed active thermal neutron detector for in-phantom measurements in a medical LINAC

    Energy Technology Data Exchange (ETDEWEB)

    Bodogni, R.; Sanchez-Doblado, F.; Pola, A.; Gentile, A.; Esposito, A.; Gomez-ros, J. M.; Pressello, M. C.; Lagares, J. I.; Terron, J. A.; Gomez, F.

    2013-07-01

    In this work a newly developed active thermal neutron detector, based on a solid state analog device, was used to determine the thermal neutron fluence in selected positions of a simplified human phantom undergoing radiotherapy with a 15 MV LINAC. The results are compared with TLD, the predictions from a Monte Carlo simulation and with measurements indirectly performed with a digital device, located far from the phantom, inside the treatment room. In this work only TLD comparison is presented. Since active neutron instruments are usually affected by systematic deviations when used in a pulsed field with large photon background, the new detector offered in this work may represent an innovative and useful tool for neutron evaluations in accelerator-based radiotherapy. (Author)

  6. Idaho National Laboratory Research & Development Impacts

    Energy Technology Data Exchange (ETDEWEB)

    Stricker, Nicole [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-01-01

    Technological advances that drive economic growth require both public and private investment. The U.S. Department of Energy’s national laboratories play a crucial role by conducting the type of research, testing and evaluation that is beyond the scope of regulators, academia or industry. Examples of such work from the past year can be found in these pages. Idaho National Laboratory’s engineering and applied science expertise helps deploy new technologies for nuclear energy, national security and new energy resources. Unique infrastructure, nuclear material inventory and vast expertise converge at INL, the nation’s nuclear energy laboratory. Productive partnerships with academia, industry and government agencies deliver high-impact outcomes. This edition of INL’s Impacts magazine highlights national and regional leadership efforts, growing capabilities, notable collaborations, and technology innovations. Please take a few minutes to learn more about the critical resources and transformative research at one of the nation’s premier applied science laboratories.

  7. Development of collaborative-creative learning model using virtual laboratory media for instrumental analytical chemistry lectures

    Science.gov (United States)

    Zurweni, Wibawa, Basuki; Erwin, Tuti Nurian

    2017-08-01

    The framework for teaching and learning in the 21st century was prepared with 4Cs criteria. Learning providing opportunity for the development of students' optimal creative skills is by implementing collaborative learning. Learners are challenged to be able to compete, work independently to bring either individual or group excellence and master the learning material. Virtual laboratory is used for the media of Instrumental Analytical Chemistry (Vis, UV-Vis-AAS etc) lectures through simulations computer application and used as a substitution for the laboratory if the equipment and instruments are not available. This research aims to design and develop collaborative-creative learning model using virtual laboratory media for Instrumental Analytical Chemistry lectures, to know the effectiveness of this design model adapting the Dick & Carey's model and Hannafin & Peck's model. The development steps of this model are: needs analyze, design collaborative-creative learning, virtual laboratory media using macromedia flash, formative evaluation and test of learning model effectiveness. While, the development stages of collaborative-creative learning model are: apperception, exploration, collaboration, creation, evaluation, feedback. Development of collaborative-creative learning model using virtual laboratory media can be used to improve the quality learning in the classroom, overcome the limitation of lab instruments for the real instrumental analysis. Formative test results show that the Collaborative-Creative Learning Model developed meets the requirements. The effectiveness test of students' pretest and posttest proves significant at 95% confidence level, t-test higher than t-table. It can be concluded that this learning model is effective to use for Instrumental Analytical Chemistry lectures.

  8. Adapted to change: The rapid development of symbiosis in newly settled, fast-maturing chemosymbiotic mussels in the deep sea.

    Science.gov (United States)

    Laming, Sven R; Duperron, Sébastien; Gaudron, Sylvie M; Hilário, Ana; Cunha, Marina R

    2015-12-01

    Symbioses between microbiota and marine metazoa occur globally at chemosynthetic habitats facing imminent threat from anthropogenic disturbance, yet little is known concerning the role of symbiosis during early development in chemosymbiotic metazoans: a critical period in any benthic species' lifecycle. The emerging symbiosis of Idas (sensu lato) simpsoni mussels undergoing development is assessed over a post-larval-to-adult size spectrum using histology and fluorescence in situ hybridisation (FISH). Post-larval development shows similarities to that of both heterotrophic and chemosymbiotic mussels. Data from newly settled specimens confirm aposymbiotic, planktotrophic larval development. Sulphur-oxidising (SOX) symbionts subsequently colonise multiple exposed, non-ciliated epithelia shortly after metamorphosis, but only become abundant on gills as these expand with greater host size. This wide-spread bathymodiolin recorded from sulphidic wood, bone and cold-seep habitats, displays a suite of adaptive traits that could buffer against anthropogenic disturbance. Copyright © 2015 Elsevier Ltd. All rights reserved.

  9. Critical role of developing national strategic plans as a guide to strengthen laboratory health systems in resource-poor settings.

    Science.gov (United States)

    Nkengasong, John N; Mesele, Tsehaynesh; Orloff, Sherry; Kebede, Yenew; Fonjungo, Peter N; Timperi, Ralph; Birx, Deborah

    2009-06-01

    Medical laboratory services are an essential, yet often neglected, component of health systems in developing countries. Their central role in public health, disease control and surveillance, and patient management is often poorly recognized by governments and donors. However, medical laboratory services in developing countries can be strengthened by leveraging funding from other sources of HIV/AIDS prevention, care, surveillance, and treatment programs. Strengthening these services will require coordinated efforts by national governments and partners and can be achieved by establishing and implementing national laboratory strategic plans and policies that integrate laboratory systems to combat major infectious diseases. These plans should take into account policy, legal, and regulatory frameworks; the administrative and technical management structure of the laboratories; human resources and retention strategies; laboratory quality management systems; monitoring and evaluation systems; procurement and maintenance of equipment; and laboratory infrastructure enhancement. Several countries have developed or are in the process of developing their laboratory plans, and others, such as Ethiopia, have implemented and evaluated their plan.

  10. Physicochemical properties of newly developed bioactive glass cement and its effects on various cells.

    Science.gov (United States)

    Washio, Ayako; Nakagawa, Aika; Nishihara, Tatsuji; Maeda, Hidefumi; Kitamura, Chiaki

    2015-02-01

    Biomaterials used in dental treatments are expected to have favorable properties such as biocompatibility and an ability to induce tissue formation in dental pulp and periapical tissue, as well as sealing to block external stimuli. Bioactive glasses have been applied in bone engineering, but rarely applied in the field of dentistry. In the present study, bioactive glass cement for dental treatment was developed, and then its physicochemical properties and effects on cell responses were analyzed. To clarify the physicochemical attributes of the cement, field emission scanning electron microscopy, X-ray diffraction, and pH measurement were carried out. Cell attachment, morphology, and viability to the cement were also examined to clarify the effects of the cement on odontoblast-like cells (KN-3 cells), osteoblastic cells (MC3T3-E1 cells), human periodontal ligament stem/progenitor cells and neuro-differentiative cells (PC-12 cells). Hydroxyapatite-like precipitation was formed on the surface of the hardened cement and the pH level changed from pH10 to pH9, then stabilized in simulate body fluid. The cement had no cytotxic effects on these cells, and particulary induced process elongation of PC-12 cells. Our results suggest that the newly developed bioactive glass cement have capability of the application in dental procedures as bioactive cement. © 2014 Wiley Periodicals, Inc.

  11. Newly developed low-temperature scanning tunneling microscope and its application to the study of superconducting materials

    International Nuclear Information System (INIS)

    Gao, F.; Dai, C.; Chen, Z.; Huang, G.; Bai, C.; Tao, H.; Yin, B.; Yang, Q.; Zhao, Z.

    1994-01-01

    A newly developed scanning tunneling microscope (STM) capable of operating at room temperature, 77 K, and 4.2 K is presented. This compact STM has a highly symmetric and rigid tunneling unit designed as an integral frame except the coarse and fine adjustment parts. The tunneling unit is incorporated into a small vacuum chamber that is usually pumped down to 2x10 -4 Pa to avoid water contamination. The fine mechanic adjustment makes the tip approach the sample in 5 nm steps. The coarse adjustment not only changes the distance between the tip and the sample, but also adjusts the tip to be normal to the surface of the sample. With this low-temperature STM atomic resolution images of Bi-2212 single-crystal and large-scale topographies of a YBa 2 Cu 3 O 7 thin film are observed at 77 K

  12. Building Transnational Bodies: Norway and the International Development of Laboratory Animal Science, ca. 1956–1980

    Science.gov (United States)

    Druglitrø, Tone; Kirk, Robert G. W.

    2015-01-01

    Argument This article adopts a historical perspective to examine the development of Laboratory Animal Science and Medicine, an auxiliary field which formed to facilitate the work of the biomedical sciences by systematically improving laboratory animal production, provision, and maintenance in the post Second World War period. We investigate how Laboratory Animal Science and Medicine co-developed at the local level (responding to national needs and concerns) yet was simultaneously transnational in orientation (responding to the scientific need that knowledge, practices, objects and animals circulate freely). Adapting the work of Tsing (2004), we argue that national differences provided the creative “friction” that helped drive the formation of Laboratory Animal Science and Medicine as a transnational endeavor. Our analysis engages with the themes of this special issue by focusing on the development of Laboratory Animal Science and Medicine in Norway, which both informed wider transnational developments and was formed by them. We show that Laboratory Animal Science and Medicine can only be properly understood from a spatial perspective; whilst it developed and was structured through national “centers,” its orientation was transnational necessitating international networks through which knowledge, practice, technologies, and animals circulated. More and better laboratory animals are today required than ever before, and this demand will continue to rise if it is to keep pace with the quickening tempo of biological and veterinary research. The provision of this living experimental material is no longer a local problem; local, that is, to the research institute. It has become a national concern, and, in some of its aspects . . . even international. (William Lane-Petter 1957, 240) PMID:24941794

  13. Adapting and Using Scrum in a Software Research and Development Laboratory

    Directory of Open Access Journals (Sweden)

    LIMA, I. R.

    2012-06-01

    Full Text Available Agile software development has gained importance in the industry because of its approach on the issues of human agility and return on investment. This paper shows how Scrum agile software project management methodology has been deployed and adapted to the model of software project management of a research and development laboratory. As a result of this deployment, experiences and lessons learned in seven real projects developed by the authors are reported.

  14. Developing a competency framework for U.S. state food and feed testing laboratory personnel.

    Science.gov (United States)

    Kaml, Craig; Weiss, Christopher C; Dezendorf, Paul; Ishida, Maria; Rice, Daniel H; Klein, Ron; Salfinger, Yvonne

    2014-01-01

    A competency-based training curriculum framework for U.S. state food and feed testing laboratories personnel is being developed by the International Food Protection Training Institute (IFPTI) and three partners. The framework will help laboratories catalog existing training courses/modules, identify training gaps, inform training curricula, and create career-spanning professional development learning paths, ensuring consistent performance expectations and increasing confidence in shared test results. Ultimately, the framework will aid laboratories in meeting the requirements of ISO/IEC 17025 (2005) international accreditation and the U.S. Food Safety Modernization Act (U.S. Public Law 111-353). In collaboration with the Association of Food and Drug Officials, the Association of Public Health Laboratories, and the Association of American Feed Control Officials, IFPTI is carrying out the project in two phases. In 2013, an expert panel of seven subject matter experts developed competency and curriculum frameworks for five professional levels (entry, mid-level, expert, supervisor/manager, and senior administration) across four competency domains (technical, communication, programmatic, and leadership) including approximately 80 competencies. In 2014 the expert panel will elicit feedback from peers and finalize the framework.

  15. Laboratory directed research and development FY91. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, S.E.; Hedman, I.; Kirvel, R.D.; McGregor, C.K. [eds.

    1991-12-31

    This review of research programs at Lawrence Livermore National Laboratory is composed of individual papers on various subjects. Broad topics of interest are: chemistry and materials science, computation, earth sciences, engineering, nuclear physics, and physics, and biology. Director`s initiatives include the development of a transgenic mouse, accelerator mass spectrometry, high-energy physics detectors, massive parallel computing, astronomical telescopes, the Kuwaiti oil fires and a compact torus accelerator. (GHH)

  16. Summary report - development of laboratory tests and the stress- strain behaviour of Olkiluoto mica gneiss

    International Nuclear Information System (INIS)

    Hakala, M.; Heikkilae, E.

    1997-05-01

    This work summarizes the project aimed at developing and qualifying a suitable combination of laboratory tests to establish a statistically reliable stress-strain behaviour of the main rock types at Posiva Oy's detailed investigation sites for disposal of spent nuclear fuel. The work includes literature study of stress-strain behaviour of brittle rock, development and qualification of laboratory tests, suggested test procedures and interpretation methods and finally testing of Olkiluoto mica gneiss. The Olkiluoto study includes over 130 loading tests. Besides the commonly used laboratory tests, direct tensile tests, damage controlled tests and acoustic emission measurements were also carried out. (orig.) (54 refs.)

  17. Accelerator laboratories: development centers for experimental physics and technology in Mexico

    International Nuclear Information System (INIS)

    Mazari, M.

    1989-01-01

    Three years ago in this Nuclear Center the author and Professor Graef expounded the inception and development of experimental physics and new techniques centered about laboratories and equipped in our country with positive ion accelerators. Extracted here is the information on the laboratories that have allowed professional training as well as the furtherance of scientific productivity in each group. An additional proposal as to how the technical groups knowledgeable in advanced technology might contribute significantly to adequate preparation of youth at the intermediate level able to generate innocuous micro industries in their own neighbourhood. (Author). 5 refs, 2 figs, 2 tabs

  18. 1996 Laboratory directed research and development annual report

    Energy Technology Data Exchange (ETDEWEB)

    Meyers, C.E.; Harvey, C.L.; Lopez-Andreas, L.M.; Chavez, D.L.; Whiddon, C.P. [comp.

    1997-04-01

    This report summarizes progress from the Laboratory Directed Research and Development (LDRD) program during fiscal year 1996. In addition to a programmatic and financial overview, the report includes progress reports from 259 individual R&D projects in seventeen categories. The general areas of research include: engineered processes and materials; computational and information sciences; microelectronics and photonics; engineering sciences; pulsed power; advanced manufacturing technologies; biomedical engineering; energy and environmental science and technology; advanced information technologies; counterproliferation; advanced transportation; national security technology; electronics technologies; idea exploration and exploitation; production; and science at the interfaces - engineering with atoms.

  19. Laboratory Directed Research and Development Program, FY 1992

    Energy Technology Data Exchange (ETDEWEB)

    1993-01-01

    This report is compiled from annual reports submitted by principal investigators following the close of the 1992 fiscal year. It describes the projects supported and summarizes their accomplishments. It constitutes a part of the Laboratory Directed Research and Development program planning and documentation process that includes an annual planning cycle, projection selection, implementation, and review. The Divisions that report include: Accelerator and Fusion Research, Chemical Sciences, Earth Sciences, Energy and Environment, Engineering, Environment and Safety and Health, Information and Computing Sciences, Life Sciences, Materials Sciences, Nuclear Science, Physics and Structural Biology.

  20. Laboratory Directed Research and Development Program, FY 1992

    International Nuclear Information System (INIS)

    1993-01-01

    This report is compiled from annual reports submitted by principal investigators following the close of the 1992 fiscal year. It describes the projects supported and summarizes their accomplishments. It constitutes a part of the Laboratory Directed Research and Development program planning and documentation process that includes an annual planning cycle, projection selection, implementation, and review. The Divisions that report include: Accelerator and Fusion Research, Chemical Sciences, Earth Sciences, Energy and Environment, Engineering, Environment and Safety and Health, Information and Computing Sciences, Life Sciences, Materials Sciences, Nuclear Science, Physics and Structural Biology

  1. Feasibility and preliminary effects of an intervention targeting schema development for caregivers of newly admitted hospice patients.

    Science.gov (United States)

    Lindstrom, Kathryn B; Mazurek Melnyk, Bernadette

    2013-06-01

    The transition to hospice care is a stressful experience for caregivers, who report high anxiety, unpreparedness, and lack of confidence. These sequelae are likely explained by the lack of an accurate cognitive schema, not knowing what to expect or how to help their loved one. Few interventions exist for this population and most do not measure preparedness, confidence, and anxiety using a schema building a conceptual framework for a new experience. The purpose of this study was to test the feasibility and preliminary effects of an intervention program, Education and Skill building Intervention for Caregivers of Hospice patients (ESI-CH), using an innovative conceptual design that targets cognitive schema development and basic skill building for caregivers of loved ones newly admitted to hospice services. A pre-experimental one-group pre- and post-test study design was used. Eighteen caregivers caring for loved ones in their homes were recruited and twelve completed the pilot study. Depression, anxiety, activity restriction, preparedness, and beliefs/confidence were measured. Caregivers reported increased preparedness, more helpful beliefs, and more confidence about their ability to care for their loved one. Preliminary trends suggested decreased anxiety levels for the intervention group. Caregivers who completed the intervention program rated the program very good or excellent, thought the information was helpful and timely, and would recommend it to friends. Results show promise that the ESI-CH program may assist as an evidence-based program to support caregivers in their role as a caregiver to a newly admitted hospice patient.

  2. LABORATORY DIRECTED RESEARCH AND DEVELOPMENT ANNUAL REPORT TO THE DEPARTMENT OF ENERGY - DECEMBER 2004

    Energy Technology Data Exchange (ETDEWEB)

    FOX,K.J.

    2004-12-31

    Brookhaven National (BNL) Laboratory is a multidisciplinary laboratory that carries out basic and applied research in the physical, biomedical, and environmental sciences, and in selected energy technologies. It is managed by Brookhaven Science Associates, LLC, under contract with the U. S. Department of Energy. BNL's total annual budget has averaged about $460 million. There are about 2,800 employees, and another 4,500 guest scientists and students who come each year to use the Laboratory's facilities and work with the staff. The BNL Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) annually in March, as required by DOE Order 4 13.2A, ''Laboratory Directed Research and Development,'' January 8, 2001, and the LDRD Annual Report guidance, updated February 12, 1999. The LDRD Program obtains its funds through the Laboratory overhead pool and operates under the authority of DOE Order 413.2A. The goals and objectives of BNL's LDRD Program can be inferred from the Program's stated purposes. These are to (1) encourage and support the development of new ideas and technology, (2) promote the early exploration and exploitation of creative and innovative concepts, and (3) develop new ''fundable'' R&D projects and programs. The emphasis is clearly articulated by BNL to be on supporting exploratory research ''which could lead to new programs, projects, and directions'' for the Laboratory. As one of the premier scientific laboratories of the DOE, BNL must continuously foster groundbreaking scientific research. At Brookhaven National Laboratory one such method is through its LDRD Program. This discretionary research and development tool is critical in maintaining the scientific excellence and long-term vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community and foster new science and technology

  3. LABORATORY DIRECTED RESEARCH AND DEVELOPMENT ANNUAL REPORT TO THE DEPARTMENT OF ENERGY - DECEMBER 2003

    Energy Technology Data Exchange (ETDEWEB)

    FOX,K.J.

    2003-12-31

    Brookhaven National (BNL) Laboratory is a multidisciplinary laboratory that carries out basic and applied research in the physical, biomedical, and environmental sciences, and in selected energy technologies. It is managed by Brookhaven Science Associates, LLC, under contract with the U. S. Department of Energy. BNL's total annual budget has averaged about $450 million. There are about 3,000 employees, and another 4,500 guest scientists and students who come each year to use the Laboratory's facilities and work with the staff. The BNL Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) annually in March, as required by DOE Order 41 3.2A, ''Laboratory Directed Research and Development,'' January 8, 2001, and the LDRD Annual Report guidance, updated February 12, 1999. The LDRD Program obtains its funds through the Laboratory overhead pool and operates under the authority of DOE Order 413.2A. The goals and objectives of BNL's LDRD Program can be inferred from the Program's stated purposes. These are to (1) encourage and support the development of new ideas and technology, (2) promote the early exploration and exploitation of creative and innovative concepts, and (3) develop new ''fundable'' R&D projects and programs. The emphasis is clearly articulated by BNL to be on supporting exploratory research ''which could lead to new programs, projects, and directions'' for the Laboratory. As one of the premier scientific laboratories of the DOE, BNL must continuously foster groundbreaking scientific research. At Brookhaven National Laboratory one such method is through its LDRD Program. This discretionary research and development tool is critical in maintaining the scientific excellence and long-term vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community and foster new science and technology

  4. Develop virtual joint laboratory for education like distance engineering system for robotic applications

    Science.gov (United States)

    Latinovic, T. S.; Deaconu, S. I.; Latinović, M. T.; Malešević, N.; Barz, C.

    2015-06-01

    This paper work with a new system that provides distance learning and online training engineers. The purpose of this paper is to develop and provide web-based system for the handling and control of remote devices via the Internet. Remote devices are currently the industry or mobile robots [13]. For future product development machine in the factory will be included in the system. This article also discusses the current use of virtual reality tools in the fields of science and engineering education. One programming tool in particular, virtual reality modeling language (VRML) is presented in the light of its applications and capabilities in the development of computer visualization tool for education. One contribution of this paper is to present the software tools and examples that can encourage educators to develop a virtual reality model to improve teaching in their discipline. [12] This paper aims to introduce a software platform, called VALIP where users can build, share, and manipulate 3D content in cooperation with the interaction processes in a 3D context, while participating hardware and software devices can be physical and / or logical distributed and connected together via the Internet. VALIP the integration of virtual laboratories to appropriate partners; therefore, allowing access to all laboratories in any of the partners in the project. VALIP provides advanced laboratory for training and research within robotics and production engineering, and thus, provides a great laboratory facilities with only having to invest a limited amount of resources at the local level to the partner site.

  5. Developing a Virtual Rock Deformation Laboratory

    Science.gov (United States)

    Zhu, W.; Ougier-simonin, A.; Lisabeth, H. P.; Banker, J. S.

    2012-12-01

    Experimental rock physics plays an important role in advancing earthquake research. Despite its importance in geophysics, reservoir engineering, waste deposits and energy resources, most geology departments in U.S. universities don't have rock deformation facilities. A virtual deformation laboratory can serve as an efficient tool to help geology students naturally and internationally learn about rock deformation. Working with computer science engineers, we built a virtual deformation laboratory that aims at fostering user interaction to facilitate classroom and outreach teaching and learning. The virtual lab is built to center around a triaxial deformation apparatus in which laboratory measurements of mechanical and transport properties such as stress, axial and radial strains, acoustic emission activities, wave velocities, and permeability are demonstrated. A student user can create her avatar to enter the virtual lab. In the virtual lab, the avatar can browse and choose among various rock samples, determine the testing conditions (pressure, temperature, strain rate, loading paths), then operate the virtual deformation machine to observe how deformation changes physical properties of rocks. Actual experimental results on the mechanical, frictional, sonic, acoustic and transport properties of different rocks at different conditions are compiled. The data acquisition system in the virtual lab is linked to the complied experimental data. Structural and microstructural images of deformed rocks are up-loaded and linked to different deformation tests. The integration of the microstructural image and the deformation data allows the student to visualize how forces reshape the structure of the rock and change the physical properties. The virtual lab is built using the Game Engine. The geological background, outstanding questions related to the geological environment, and physical and mechanical concepts associated with the problem will be illustrated on the web portal. In

  6. LDRD 2016 Annual Report: Laboratory Directed Research and Development Program Activities

    Energy Technology Data Exchange (ETDEWEB)

    Hatton, D. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2017-03-31

    Each year, Brookhaven National Laboratory (BNL) is required to provide a program description and overview of its Laboratory Directed Research and Development Program (LDRD) to the Department of Energy (DOE) in accordance with DOE Order 413.2C dated October 22, 2015. This report provides a detailed look at the scientific and technical activities for each of the LDRD projects funded by BNL in FY 2016, as required. In FY 2016, the BNL LDRD Program funded 48 projects, 21 of which were new starts, at a total cost of $11.5M. The investments that BNL makes in its LDRD program support the Laboratory’s strategic goals. BNL has identified four Critical Outcomes that define the Laboratory’s scientific future and that will enable it to realize its overall vision. Two operational Critical Outcomes address essential operational support for that future: renewal of the BNL campus; and safe, efficient laboratory operations.

  7. Development of excavation technologies at the Canadian underground research laboratory

    International Nuclear Information System (INIS)

    Kuzyk, Gregory W.; Martino, Jason B.

    2008-01-01

    Several countries, Canada being among them, are developing concepts for disposal of used fuel from power generating nuclear reactors. As in underground mining operations, the disposal facilities will require excavation of many kilometres of shafts and tunnels through the host rock mass. The need to maintain the stability of excavations and safety of workers will be of paramount importance. Also, excavations required for many radioactive waste repositories will ultimately need to be backfilled and sealed to maintain stability and minimize any potential for migration of radionuclides, should they escape their disposal containers. The method used to excavate the tunnels and shafts, and the rock damage that occurs due to excavation, will greatly affect the performance characteristics of repository sealing systems. The underground rock mechanics and geotechnical engineering work performed at the Canadian Underground Research Laboratory (URL) has led to the development of excavation technologies that reduce rock damage in subsurface excavations. This paper discusses the excavation methods used to construct the URL and their application in planning for the construction of similar underground laboratories and repositories for radioactive wastes. (author)

  8. Fluorescent and radiolabelling of pepsin-digested human glomerular basement membrane with a newly developed hydroxy-coumarin derivative (CASE)

    International Nuclear Information System (INIS)

    Rand-Weaver, M.; Abuknesha, R.A.; Price, R.G.

    1985-01-01

    The labelling of pepsin-digested human glomerular basement membrane (pHGBM) with a newly developed fluorescent iodine acceptor 7-hydroxy-coumarin-3-acetic acid N-hydroxysucciniimydyl ester (CASE) is described. The binding of a monoclonal antibody to pHGBM was assessed by radiobinding assays, and when directly iodinated pHGBM was used there was no apparent binding. When CASE was conjugated to pHGBM prior to iodination 11% binding was achieved. CASE acting as an iodine acceptor may be useful for proteins containing few or inaccessible tyrosine residues or which are destroyed by introduction of 125 I. Since CASE is fluorescent, small amounts of material can be detected during isolation prior to iodination. (orig.)

  9. Developments at the Gran Sasso laboratory

    CERN Multimedia

    2003-01-01

    The INFN Laboratory at Gran Sasso is a sanctuary for neutrinos. Located 963 metres over the sea level, it is protected by the 1400 metres of the rock of Gran Sasso mountain, next to the road tunnel of the same name, 120 km from Rome in Italy. It was from this underground location, ideal for receiving a high-energy neutrino beam from CERN, that first sprang the idea for the CNGS (CERN Neutrinos to Gran Sasso) project. However, an accident which occurred in one of the Laboratory's three experimental halls last August resulted in its temporary closure, leaving a question mark over the project's future. Today, following a legal ruling, certain scientific activities are now starting up again. Angelo Scribano, the vice-president of INFN, takes stock of the situation. "After a difficult year, it seems that an air of optimism is back in the INFN laboratories at Gran Sasso. On 17th June 2003, the competent court of the city of Teramo agreed to certain scientific activities starting up again in Hall C as requested b...

  10. Transitioning glass-ceramic scintillators for diagnostic x-ray imaging from the laboratory to commercial scale

    Science.gov (United States)

    Beckert, M. Brooke; Gallego, Sabrina; Elder, Eric; Nadler, Jason

    2016-10-01

    This study sought to mitigate risk in transitioning newly developed glass-ceramic scintillator technology from a laboratory concept to commercial product by identifying the most significant hurdles to increased scale. These included selection of cost effective raw material sources, investigation of process parameters with the most significant impact on performance, and synthesis steps that could see the greatest benefit from participation of an industry partner that specializes in glass or optical component manufacturing. Efforts focused on enhancing the performance of glass-ceramic nanocomposite scintillators developed specifically for medical imaging via composition and process modifications that ensured efficient capture of incident X-ray energy and emission of scintillation light. The use of cost effective raw materials and existing manufacturing methods demonstrated proof-of-concept for economical viable alternatives to existing benchmark materials, as well as possible disruptive applications afforded by novel geometries and comparatively lower cost per volume. The authors now seek the expertise of industry to effectively navigate the transition from laboratory demonstrations to pilot scale production and testing to evince the industry of the viability and usefulness of composite-based scintillators.

  11. Renewable Energy Laboratory Development for Biofuels Advanced Combustion Studies

    Energy Technology Data Exchange (ETDEWEB)

    Soloiu, Valentin A. [Georgia Southern Univ., Statesboro, GA (United States)

    2012-03-31

    The research advanced fundamental science and applied engineering for increasing the efficiency of internal combustion engines and meeting emissions regulations with biofuels. The project developed a laboratory with new experiments and allowed investigation of new fuels and their combustion and emissions. This project supports a sustainable domestic biofuels and automotive industry creating economic opportunities across the nation, reducing the dependence on foreign oil, and enhancing U.S. energy security. The one year period of research developed fundamental knowledge and applied technology in advanced combustion, emissions and biofuels formulation to increase vehicle's efficiency. Biofuels combustion was investigated in a Compression Ignition Direct Injection (DI) to develop idling strategies with biofuels and an Indirect Diesel Injection (IDI) intended for auxiliary power unit.

  12. Chemistry Graduate Teaching Assistants' Experiences in Academic Laboratories and Development of a Teaching Self-image

    Science.gov (United States)

    Gatlin, Todd Adam

    Graduate teaching assistants (GTAs) play a prominent role in chemistry laboratory instruction at research based universities. They teach almost all undergraduate chemistry laboratory courses. However, their role in laboratory instruction has often been overlooked in educational research. Interest in chemistry GTAs has been placed on training and their perceived expectations, but less attention has been paid to their experiences or their potential benefits from teaching. This work was designed to investigate GTAs' experiences in and benefits from laboratory instructional environments. This dissertation includes three related studies on GTAs' experiences teaching in general chemistry laboratories. Qualitative methods were used for each study. First, phenomenological analysis was used to explore GTAs' experiences in an expository laboratory program. Post-teaching interviews were the primary data source. GTAs experiences were described in three dimensions: doing, knowing, and transferring. Gains available to GTAs revolved around general teaching skills. However, no gains specifically related to scientific development were found in this laboratory format. Case-study methods were used to explore and illustrate ways GTAs develop a GTA self-image---the way they see themselves as instructors. Two general chemistry laboratory programs that represent two very different instructional frameworks were chosen for the context of this study. The first program used a cooperative project-based approach. The second program used weekly, verification-type activities. End of the semester interviews were collected and served as the primary data source. A follow-up case study of a new cohort of GTAs in the cooperative problem-based laboratory was undertaken to investigate changes in GTAs' self-images over the course of one semester. Pre-semester and post-semester interviews served as the primary data source. Findings suggest that GTAs' construction of their self-image is shaped through the

  13. Development of a Laboratory Project to Determine Human ABO Genotypes--Limitations Lead to Further Student Explorations

    Science.gov (United States)

    Salerno, Theresa A.

    2009-01-01

    A multiplex allele-specific PCR analysis was developed to identify six "common" genotypes: AA, AO, BB, BO, OO, and AB. This project included a pre-laboratory exercise that provided active learning experiences and developed critical thinking skills. This laboratory resulted in many successful analyses, which were verified by student knowledge of…

  14. Developing Learning Tool of Control System Engineering Using Matrix Laboratory Software Oriented on Industrial Needs

    Science.gov (United States)

    Isnur Haryudo, Subuh; Imam Agung, Achmad; Firmansyah, Rifqi

    2018-04-01

    The purpose of this research is to develop learning media of control technique using Matrix Laboratory software with industry requirement approach. Learning media serves as a tool for creating a better and effective teaching and learning situation because it can accelerate the learning process in order to enhance the quality of learning. Control Techniques using Matrix Laboratory software can enlarge the interest and attention of students, with real experience and can grow independent attitude. This research design refers to the use of research and development (R & D) methods that have been modified by multi-disciplinary team-based researchers. This research used Computer based learning method consisting of computer and Matrix Laboratory software which was integrated with props. Matrix Laboratory has the ability to visualize the theory and analysis of the Control System which is an integration of computing, visualization and programming which is easy to use. The result of this instructional media development is to use mathematical equations using Matrix Laboratory software on control system application with DC motor plant and PID (Proportional-Integral-Derivative). Considering that manufacturing in the field of Distributed Control systems (DCSs), Programmable Controllers (PLCs), and Microcontrollers (MCUs) use PID systems in production processes are widely used in industry.

  15. Summary report - development of laboratory tests and the stress- strain behaviour of Olkiluoto mica gneiss

    Energy Technology Data Exchange (ETDEWEB)

    Hakala, M.; Heikkilae, E. [Helsinki Univ. of Technology, Espoo (Finland). Lab. of Rock Engineering

    1997-05-01

    This work summarizes the project aimed at developing and qualifying a suitable combination of laboratory tests to establish a statistically reliable stress-strain behaviour of the main rock types at Posiva Oy`s detailed investigation sites for disposal of spent nuclear fuel. The work includes literature study of stress-strain behaviour of brittle rock, development and qualification of laboratory tests, suggested test procedures and interpretation methods and finally testing of Olkiluoto mica gneiss. The Olkiluoto study includes over 130 loading tests. Besides the commonly used laboratory tests, direct tensile tests, damage controlled tests and acoustic emission measurements were also carried out. (orig.) (54 refs.).

  16. Response Matrix Method Development Program at Savannah River Laboratory

    International Nuclear Information System (INIS)

    Sicilian, J.M.

    1976-01-01

    The Response Matrix Method Development Program at Savannah River Laboratory (SRL) has concentrated on the development of an effective system of computer codes for the analysis of Savannah River Plant (SRP) reactors. The most significant contribution of this program to date has been the verification of the accuracy of diffusion theory codes as used for routine analysis of SRP reactor operation. This paper documents the two steps carried out in achieving this verification: confirmation of the accuracy of the response matrix technique through comparison with experiment and Monte Carlo calculations; and establishment of agreement between diffusion theory and response matrix codes in situations which realistically approximate actual operating conditions

  17. 77 FR 26069 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Science.gov (United States)

    2012-05-02

    ... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development Services Scientific Merit Review Board, Notice of Meeting Amendment The... Development and Clinical Science Research and Development Services Scientific Merit Review Board have changed...

  18. Report on operation, utilization and technical development of research reactors and hot laboratory

    International Nuclear Information System (INIS)

    1980-03-01

    Activities of the Division of Research Reactor Operation in fiscal 1978 are described. The division is responsible for operation and maintenance of JRR-2, JRR-3, JRR-4 and Hot Laboratory. In the above connection, various other works are performed, including technical management of fuel and coolant, radiation control, irradiation technique, etc. In Hot Laboratory, postirradiation examinations of fuels and materials are made, and also development of examination methods. (author)

  19. Report on operation utilization and technical development of research reactors and hot laboratory

    International Nuclear Information System (INIS)

    1982-03-01

    Activities of the Division of Research Reactor Operation in fiscal 1980 are described. The division is responsible for operation and maintenance of JRR-2, JRR-3, JRR-4 and Hot Laboratory. In the above connection, various other works are performed, including technical management of fuel and coolant, radiation control, irradiation technique, etc. In Hot Laboratory, postirradiation examinations of fuels and materials are made, and also development of examination methods. (author)

  20. Report on operation, utilization and technical development of Research Reactors and Hot Laboratory

    International Nuclear Information System (INIS)

    1984-10-01

    Activities of the Division of Research Reactor Operation in fiscal 1981 are described. The division is responsible for operation and maintenance of JRR-2, JRR-3, JRR-4 and Hot Laboratory. In the above connection, various other works are performed, including technical management of fuel and coolant, radiation control, irradiation technique, etc. In Hot Laboratory, postirradiation examinations of fuels and materials are made, and also development of examination methods. (author)

  1. Laboratory Directed Research and Development FY 2000 Annual Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Los Alamos National Laboratory

    2001-05-01

    This is the FY00 Annual Progress report for the Laboratory Directed Research and Development (LDRD) Program at Los Alamos National Laboratory. It gives an overview of the LDRD Program, summarizes progress on each project conducted during FY00, characterizes the projects according to their relevance to major funding sources, and provides an index to principal investigators. Project summaries are grouped by LDRD component: Directed Research and Exploratory Research. Within each component, they are further grouped into the ten technical categories: (1) atomic, molecular, optical, and plasma physics, fluids, and beams, (2) bioscience, (3) chemistry, (4) computer science and software engineering, (5) engineering science, (6) geoscience, space science, and astrophysics, (7) instrumentation and diagnostics, (8) materials science, (9) mathematics, simulation, and modeling, and (10) nuclear and particle physics.

  2. Prognostic value of regulatory T cells in newly diagnosed chronic myeloid leukemia patients.

    Science.gov (United States)

    Zahran, Asmaa M; Badrawy, Hosny; Ibrahim, Abeer

    2014-08-01

    Chronic myeloid leukemia (CML) is a clonal disease, characterized by a reciprocal t(9, 22) that results in a chimeric BCR/ABL fusion gene. Regulatory T cells (Tregs) constitute the main cell population that enables cancer cells to evade immune surveillance. The purpose of our study was to investigate the level of Tregs in newly diagnosed CML patients and to correlate it with the patients' clinical, laboratory and molecular data. We also aimed to assess the effect of treatment using tyrosine kinase inhibitor (TKI) on Treg levels. Tregs were characterized and quantified by flow cytometry in 63 newly diagnosed CML patients and 40 healthy controls. TKI was used in 45 patients with chronic phase CML, and the response to therapy was correlated with baseline Treg levels. The percentages of Tregs were significantly increased in CML patients compared to the controls. Treg numbers were significantly lower in patients with chronic phase CML versus the accelerated and blast phases, and were significantly lower in patients with complete molecular remission (CMR) compared to those patients without CMR. Tregs may play a role in the maintenance of CML. Moreover, the decrease of their levels in patients with CMR suggests that Tregs might have a clinical value in evaluating the effects of therapy.

  3. Critical thinking dispositions among newly graduated nurses

    Science.gov (United States)

    Wangensteen, Sigrid; Johansson, Inger S; Björkström, Monica E; Nordström, Gun

    2010-01-01

    wangensteen s., johansson i.s., björkström m.e. & nordström g. (2010) Critical thinking dispositions among newly graduated nurses. Journal of Advanced Nursing66(10), 2170–2181. Aim The aim of the study was to describe critical thinking dispositions among newly graduated nurses in Norway, and to study whether background data had any impact on critical thinking dispositions. Background Competence in critical thinking is one of the expectations of nursing education. Critical thinkers are described as well-informed, inquisitive, open-minded and orderly in complex matters. Critical thinking competence has thus been designated as an outcome for judging the quality of nursing education programmes and for the development of clinical judgement. The ability to think critically is also described as reducing the research–practice gap and fostering evidence-based nursing. Methods A cross-sectional descriptive study was performed. The data were collected between October 2006 and April 2007 using the California Critical Thinking Disposition Inventory. The response rate was 33% (n= 618). Pearson’s chi-square tests were used to analyse the data. Results Nearly 80% of the respondents reported a positive disposition towards critical thinking. The highest mean score was on the Inquisitiveness subscale and the lowest on the Truth-seeking subscale. A statistically significant higher proportion of nurses with high critical thinking scores were found among those older than 30 years, those with university education prior to nursing education, and those working in community health care. Conclusion Nurse leaders and nurse teachers should encourage and nurture critical thinking among newly graduated nurses and nursing students. The low Truth-seeking scores found may be a result of traditional teaching strategies in nursing education and might indicate a need for more student-active learning models. PMID:20384637

  4. High Power Laser Laboratory at the Institute of Plasma Physics and Laser Microfusion: equipment and preliminary research

    Directory of Open Access Journals (Sweden)

    Zaraś-Szydłowska Agnieszka

    2015-06-01

    Full Text Available The purpose of this paper is to present the newly-opened High Power Laser Laboratory (HPLL at the Institute of Plasma Physics and Laser Microfusion (IPPLM. This article describes the laser, the main laboratory accessories and the diagnostic instruments. We also present preliminary results of the first experiment on ion and X-ray generation from laser-produced plasma that has been already performed at the HPLL.

  5. Development of an in vitro laboratory manual for nuclear medicine technology students

    International Nuclear Information System (INIS)

    Meyers, A.

    1989-01-01

    This study evaluated existing in vitro education materials in qualitative and quantitative parameters that currently exist to educate potential clinicians of nationally accredited nuclear medicine programs. A review of over 300 articles, texts, and manuals pertaining to in vitro nuclear medicine procedures clearly demonstrated that no in vitro laboratory manual for undergraduate students presently exited. Every nuclear medicine program director in the United States was surveyed. They were asked for their overall philosophy in terms of developing an in vitro manual and requested to evaluate the significant of 22 general principles/concepts and 34 specific laboratory testing procedures. From the response to the survey, an in vitro nuclear medicine manual was created and appended to the study. The manual consists of lecture and study material, chapter reviews, and laboratory assignments and exercises

  6. The national laboratory business role in energy technology research and development. Panel Discussion

    International Nuclear Information System (INIS)

    Sackett, John; Sullivan, Charles J.; Aumeier, Steve; Sanders, Tom; Johnson, Shane; Bennett, Ralph

    2001-01-01

    Full text of publication follows: Energy issues will play a pivotal role in the economic and political future of the United States. For reasons of both available supply and environmental concerns, development and deployment of new energy technologies is critical. Nuclear technology is important, but economic, political, and technical challenges must be overcome if it is to play a significant role. This session will address business opportunities for national laboratories to contribute to the development and implementation of a national energy strategy, concentrating on the role of nuclear technology. Panelists have been selected from the national laboratories, the U.S. Department of Energy, and state regulators. (authors)

  7. Systems integration for the Kennedy Space Center (KSC) Robotics Applications Development Laboratory (RADL)

    Science.gov (United States)

    Davis, V. Leon; Nordeen, Ross

    1988-01-01

    A laboratory for developing robotics technology for hazardous and repetitive Shuttle and payload processing activities is discussed. An overview of the computer hardware and software responsible for integrating the laboratory systems is given. The center's anthropomorphic robot is placed on a track allowing it to be moved to different stations. Various aspects of the laboratory equipment are described, including industrial robot arm control, smart systems integration, the supervisory computer, programmable process controller, real-time tracking controller, image processing hardware, and control display graphics. Topics of research include: automated loading and unloading of hypergolics for space vehicles and payloads; the use of mobile robotics for security, fire fighting, and hazardous spill operations; nondestructive testing for SRB joint and seal verification; Shuttle Orbiter radiator damage inspection; and Orbiter contour measurements. The possibility of expanding the laboratory in the future is examined.

  8. Laboratory Directed Research and Development LDRD-FY-2011

    Energy Technology Data Exchange (ETDEWEB)

    Dena Tomchak

    2012-03-01

    This report provides a summary of the research conducted at the Idaho National Laboratory (INL) during Fiscal Year (FY) 2011. This report demonstrates the types of cutting edge research the INL is performing to help ensure the nation's energy security. The research conducted under this program is aligned with our strategic direction, benefits the Department of Energy (DOE) and is in compliance with DOE order 413.2B. This report summarizes the diverse research and development portfolio with emphasis on the DOE Office of Nuclear Energy (DOE-NE) mission, encompassing both advanced nuclear science and technology and underlying technologies.

  9. Engineering fluorescent proteins towards ultimate performances: lessons from the newly developed cyan variants

    International Nuclear Information System (INIS)

    Mérola, Fabienne; Erard, Marie; Fredj, Asma; Pasquier, Hélène

    2016-01-01

    New fluorescent proteins (FPs) are constantly discovered from natural sources, and submitted to intensive engineering based on random mutagenesis and directed evolution. However, most of these newly developed FPs fail to achieve all the performances required for their bioimaging applications. The design of highly optimised FP-based reporters, simultaneously displaying appropriate colour, multimeric state, chromophore maturation, brightness, photostability and environmental sensitivity will require a better understanding of the structural and dynamic determinants of FP photophysics. The recent development of cyan fluorescent proteins (CFPs) like mCerulean3, mTurquoise2 and Aquamarine brings a different view on these questions, as in this particular case, a step by step evaluation of critical mutations has been performed within a family of spectrally identical and evolutionary close variants. These efforts have led to CFPs with quantum yields close to unity, near single exponential emission decays, high photostability and complete insensitivity to pH, making them ideal choices as energy transfer donors in FRET and FLIM imaging applications. During this process, it was found that a proper amino-acid choice at only two positions (148 and 65) is sufficient to transform the performances of CFPs: with the help of structural and theoretical investigations, we rationalise here how these two positions critically control the CFP photophysics, in the context of FPs derived from the Aequorea victoria species. Today, these results provide a useful toolbox for upgrading the different CFP donors carried by FRET biosensors. They also trace the route towards the de novo design of FP-based optogenetic devices that will be perfectly tailored to dedicated imaging and sensing applications. (topical review)

  10. Meet the best Award-winning technologies from Pacific Northwest Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    1990-09-01

    The Battelle Memorial Institute has managed the Pacific Northwest Laboratory (PNL) for the US Department of Energy for 25 years. During this time, numerous new technologies have been discovered and developed at PNL as a result of our research programs. This document will introduce you to some of the more significant discoveries and newly commercialized technologies. Each of the technologies described has received an award from Research Development magazine or the Federal Laboratory Consortium--sometimes both Each technology is available to you through PNL's technology transfer program or one of our licensees. Similarly, our award-winning scientists and engineers are available to assist you as you search for innovative technologies to solve your technical problems. These researchers are familiar with current problems confronting industry, government agencies, and the academic community. They are happy to apply their skills and PNL's resources to your problems. PNL encourages its researchers to work with government agencies, universities, and US industries. PNL technology transfer programs address the nation's drive toward increased competitiveness by being flexible and aggressive, and are designed to tailor results to fit your needs and those of your clients. If you are in search of a new technology or increased competitiveness, consider collaborative efforts with our award-winning staff, whose accomplishments are synopsized in this booklet.

  11. Development of Biodiversity Laboratory to Support the Establishment of Flora and Fauna Database in the Vicinity of Nuclear Facility

    International Nuclear Information System (INIS)

    Nor Humaira Lau Abdullah; Anis Nadia Mohd Faisol Mahadeven; Mohd Noor Hidayat Adenan

    2015-01-01

    The Biodiversity Laboratory (44128) at Agrotechnology and Biosciences Division (BAB) was developed using One-Off 2014 budget. The renovation works of Seed Technology Laboratory into Biodiversity Laboratory was planned in 2013 and was fully completed in early 2015. This laboratory serves as a centre for development and storage of flora and fauna database. Thus far, this laboratory houses various facilities that befit the function of this laboratory, such as small mammalian and insects sampling tools, herbarium specimen preparation tools, fume chamber, and work benches. Among the activities carried out in this laboratory were sampling and processing of flora, fauna and mushroom specimens collected in the vicinity of nuclear facility besides exhibiting processed/preserved herbaria, mushrooms, fauna and insects specimens. On the other hand, activities planned include cataloguing of existing specimens, online database development, study on ionising radiation towards development of bio indicator, and development of Standard Operating Procedure (SOP). However there are some limitations in terms of tools (supercomputer, camera microscope, photography set-up and drying oven) and not to mention, expertise. In order to overcome the limitations, some recommendations for improvement can be considered for instance fund application, hiring staffs in desired field of expertise (botanist and zoologist) and training's. In summary, this laboratory has potential to support the aspiration of Nuclear Malaysia to be a TSO for national nuclear power development plan in the aspect of environmental and ecosystem protection especially towards non-human biota. (author)

  12. Meteorological Development Laboratory Student Career Experience Program

    Science.gov (United States)

    McCalla, C., Sr.

    2007-12-01

    The National Oceanic and Atmospheric Administration's (NOAA) National Weather Service (NWS) provides weather, hydrologic, and climate forecasts and warnings for the protection of life and property and the enhancement of the national economy. The NWS's Meteorological Development Laboratory (MDL) supports this mission by developing meteorological prediction methods. Given this mission, NOAA, NWS, and MDL all have a need to continually recruit talented scientists. One avenue for recruiting such talented scientist is the Student Career Experience Program (SCEP). Through SCEP, MDL offers undergraduate and graduate students majoring in meteorology, computer science, mathematics, oceanography, physics, and statistics the opportunity to alternate full-time paid employment with periods of full-time study. Using SCEP as a recruiting vehicle, MDL has employed students who possess some of the very latest technical skills and knowledge needed to make meaningful contributions to projects within the lab. MDL has recently expanded its use of SCEP and has increased the number of students (sometimes called co- ops) in its program. As a co-op, a student can expect to develop and implement computer based scientific techniques, participate in the development of statistical algorithms, assist in the analysis of meteorological data, and verify forecasts. This presentation will focus on describing recruitment, projects, and the application process related to MDL's SCEP. In addition, this presentation will also briefly explore the career paths of students who successfully completed the program.

  13. POPs analysis reveals issues in bringing laboratories in developing countries to a higher quality level

    NARCIS (Netherlands)

    Leeuwen, van S.P.J.; Bavel, van B.; Abad, E.; Leslie, H.A.; Fiedler, H.; Boer, de J.

    2013-01-01

    We assessed the performance of laboratories in 18 developing countries in analyzing persistent organic pollutants (POPs) in environmental and human samples, as part of a capacity-building program with the goal of helping laboratories increase proficiency in the types of analyses required for the

  14. Human factors activities in teleoperator development at the Oak Ridge National Laboratory

    International Nuclear Information System (INIS)

    Draper, J.V.; Herndon, J.N.

    1986-01-01

    The Consolidated Fuel Reprocessing Program (CFRP) at the Oak Ridge National Laboratory is developing advanced teleoperator systems for maintenance of future nuclear reprocessing facilities. Remote maintenance systems developed by the CFRP emphasize man-in-the-loop teleoperation. Consequently, human factors issues which affect teleoperator performance must be addressed. This papers surveys research and development activities carried out by the human factors group within the Remote Control Engineering Task of the CFRP

  15. A guide to the establishment and maintenance of pesticide laboratories in developing countries (NRI Bulletin No. 28)

    OpenAIRE

    Cox, J.; Halliday, D.; Kilminster, K.

    1990-01-01

    The difficulties in establishing and maintaining pesticide laboratories, particularly residue laboratories, in developing countries are addressed in an attempt to arouse a greater awareness of the commitment and resources required for successful operation. Accommodation, staffing, laboratory services, equipment and materials are all considered in detail and model specifications, including full equipment lists, are provided for both formulation and residue laboratories.

  16. Evaluating the effectiveness of a laboratory-based professional development program for science educators

    Science.gov (United States)

    Amolins, Michael W.; Ezrailson, Cathy M.; Pearce, David A.; Elliott, Amy J.

    2015-01-01

    The process of developing effective science educators has been a long-standing objective of the broader education community. Numerous studies have recommended not only depth in a teacher's subject area but also a breadth of professional development grounded in constructivist principles, allowing for successful student-centered and inquiry-based instruction. Few programs, however, have addressed the integration of the scientific research laboratory into the science classroom as a viable approach to professional development. Additionally, while occasional laboratory training programs have emerged in recent years, many lack a component for translating acquired skills into reformed classroom instruction. Given the rapid development and demand for knowledgeable employees and an informed population from the biotech and medical industries in recent years, it would appear to be particularly advantageous for the physiology and broader science education communities to consider this issue. The goal of this study was to examine the effectiveness of a laboratory-based professional development program focused on the integration of reformed teaching principles into the classrooms of secondary teachers. This was measured through the program's ability to instill in its participants elevated academic success while gaining fulfillment in the classroom. The findings demonstrated a significant improvement in the use of student-centered instruction and other reformed methods by program participants as well as improved self-efficacy, confidence, and job satisfaction. Also revealed was a reluctance to refashion established classroom protocols. The combination of these outcomes allowed for construction of an experiential framework for professional development in applied science education that supports an atmosphere of reformed teaching in the classroom. PMID:26628658

  17. Status of photovoltaics in the Newly Associated States

    International Nuclear Information System (INIS)

    Pietruszko, S.M.; Mikolajuk, A.; Fara, L.; Fara, S.; Vitanov, P.; Stratieva, N.; Rehak, J.; Barinka, R.; Mellikov, E.; Palfy, M.; Shipkovs, P.; Krotkus, A.; Saly, V.; Nemac, F.; Swens, J.; Nowak, S.; Zachariou, A.; Fechner, H.; Passiniemi, P.

    2004-01-01

    The Status of Photovoltaics in the Central and Eastern Europe presents the state of the art of photovoltaics (PV) in the Newly Associated States (NAS): Bulgaria, the Czech Republic, Estonia, Hungary, Latvia, Lithuania, Poland, Romania, Slovakia, Slovenia. The attempt was made to cover all photovoltaics activities in NAS, from research to industry and markets as well as from technology development to dissemination and education. The document covers the following topics and issues: organization of PV research and demonstration activities, stakeholders involved in research and technology development (RTD), scientific potential of NAS PV community, PV activities carried out in NAS countries, PV policies and support mechanisms, achievements and barriers, challenges and needs to the development of PV in the NAS. (authors)

  18. PPSL - the newly installed analytical system for the detection of irradiated food

    International Nuclear Information System (INIS)

    Guzik, G.P.; Stachowicz, W.

    2006-01-01

    Newly installed in the Laboratory for Detection of Irradiated Food at the beginning of 2005 Pulsed PhotoStimulated Luminescence method (PPSL) is described. Methodology of the PPSL examination of food is simple: the analysed sample is dispensed into a Petri dish in a thin layer and placed into a sample chamber. the sample is exposed to pulsed laser infra-red light emitted by an array of diodes (IR LEDs). The PPSL signal produced in the system by luminescence released from photostimulated mineral debris of the sample is stored by a photomultiplier and the created numerical signal transmitted to the PC. it has been found, that screening by means of the PPSL apparatus is easy, effective and inexpensive. The method provides the fastest way to gain results whether food product is irradiated

  19. The Activity of Carbohydrate-Degrading Enzymes in the Development of Brood and Newly Emerged workers and Drones of the Carniolan Honeybee, Apis mellifera carnica

    OpenAIRE

    Żółtowska, Krystyna; Lipiński, Zbigniew; Łopieńska-Biernat, Elżbieta; Farjan, Marek; Dmitryjuk, Małgorzata

    2012-01-01

    The activity of glycogen Phosphorylase and carbohydrate hydrolyzing enzymes α-amylase, glucoamylase, trehalase, and sucrase was studied in the development of the Carniolan honey bee, Apis mellifera carnica Pollman (Hymenoptera: Apidae), from newly hatched larva to freshly emerged imago of worker and drone. Phosphorolytic degradation of glycogen was significantly stronger than hydrolytic degradation in all developmental stages. Developmental profiles of hydrolase activity were similar in both ...

  20. Oak Ridge National Laboratory Transuranic Waste Certification Program

    International Nuclear Information System (INIS)

    Smith, J.H.; Bates, L.D.; Box, W.D.; Aaron, W.S.; Setaro, J.A.

    1988-08-01

    The US Department of Energy (DOE) has requested that all DOE facilities handling defense transuranic (TRU) waste develop and implement a program whereby all TRU waste will be contained, stored, and shipped to the Waste Isolation Pilot Plant (WIPP) in accordance with the requirements set forth in the DOE certification documents WIPP-DOE-069, 114, 120, 137, 157, and 158. The program described in this report describes how Oak Ridge National Laboratory (ORNL) intends to comply with these requirements and the techniques and procedures used to ensure that ORNL TRU wastes are certifiable for shipment to WIPP. This document describes the program for certification of newly generated (NG) contact-handled transuranic (CH-TRU) waste. Previsions have been made for addenda, which will extend the coverage of this document to include certification of stored CH-TRU and NG and stored remote-handled transuranic (RH-TRU) waste, as necessary. 24 refs., 11 figs., 4 tabs

  1. Three-dimensional quantification of cardiac surface motion: a newly developed three-dimensional digital motion-capture and reconstruction system for beating heart surgery.

    Science.gov (United States)

    Watanabe, Toshiki; Omata, Sadao; Odamura, Motoki; Okada, Masahumi; Nakamura, Yoshihiko; Yokoyama, Hitoshi

    2006-11-01

    This study aimed to evaluate our newly developed 3-dimensional digital motion-capture and reconstruction system in an animal experiment setting and to characterize quantitatively the three regional cardiac surface motions, in the left anterior descending artery, right coronary artery, and left circumflex artery, before and after stabilization using a stabilizer. Six pigs underwent a full sternotomy. Three tiny metallic markers (diameter 2 mm) coated with a reflective material were attached on three regional cardiac surfaces (left anterior descending, right coronary, and left circumflex coronary artery regions). These markers were captured by two high-speed digital video cameras (955 frames per second) as 2-dimensional coordinates and reconstructed to 3-dimensional data points (about 480 xyz-position data per second) by a newly developed computer program. The remaining motion after stabilization ranged from 0.4 to 1.01 mm at the left anterior descending, 0.91 to 1.52 mm at the right coronary artery, and 0.53 to 1.14 mm at the left circumflex regions. Significant differences before and after stabilization were evaluated in maximum moving velocity (left anterior descending 456.7 +/- 178.7 vs 306.5 +/- 207.4 mm/s; right coronary artery 574.9 +/- 161.7 vs 446.9 +/- 170.7 mm/s; left circumflex 578.7 +/- 226.7 vs 398.9 +/- 192.6 mm/s; P heart surface movement. This helps us better understand the complexity of the heart, its motion, and the need for developing a better stabilizer for beating heart surgery.

  2. Research and Development Program for transportation packagings at Sandia National Laboratories

    International Nuclear Information System (INIS)

    Hohnstreiter, G.F.; Sorenson, K.B.

    1995-01-01

    This document contains information about the research and development programs dealing with waste transport at Sandia National Laboratories. This paper discusses topics such as: Why new packaging is needed; analytical methodologies and design codes;evaluation of packaging components; materials characterization; creative packaging concepts; packaging engineering and analysis; testing; and certification support

  3. A model for mentoring newly-appointed nurse educators in nursing education institutions in South Africa.

    Science.gov (United States)

    Seekoe, Eunice

    2014-04-24

    South Africa transformed higher education through the enactment of the Higher Education Act (No. 101 of 1997). The researcher identified the need to develop a model for the mentoring of newly-appointed nurse educators in nursing education institutions in South Africa.  To develop and describe the model for mentoring newly-appointed nurse educators in nursing education institutions in South Africa.  A qualitative and theory-generating design was used (following empirical findings regarding needs analysis) in order to develop the model. The conceptualisation of the framework focused on the context, content, process and the theoretical domains that influenced the model. Ideas from different theories were borrowed from and integrated with the literature and deductive and inductive strategies were applied.  The structure of the model is multidimensional and complex in nature (macro, mesoand micro) based on the philosophy of reflective practice, competency-based practice andcritical learning theories. The assumptions are in relation to stakeholders, context, mentoring, outcome, process and dynamic. The stakeholders are the mentor and mentee within an interactive participatory relationship. The mentoring takes place within the process with a sequence of activities such as relationship building, development, engagement, reflective process and assessment. Capacity building and empowerment are outcomes of mentoring driven by motivation.  The implication for nurse managers is that the model can be used to develop mentoring programmes for newly-appointed nurse educators.

  4. Laboratory Directed Research and Development Program FY 2008 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    editor, Todd C Hansen

    2009-02-23

    The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab or LBNL) is a multi-program national research facility operated by the University of California for the Department of Energy (DOE). As an integral element of DOE's National Laboratory System, Berkeley Lab supports DOE's missions in fundamental science, energy resources, and environmental quality. Berkeley Lab programs advance four distinct goals for DOE and the nation: (1) To perform leading multidisciplinary research in the computing sciences, physical sciences, energy sciences, biosciences, and general sciences in a manner that ensures employee and public safety and protection of the environment. (2) To develop and operate unique national experimental facilities for qualified investigators. (3) To educate and train future generations of scientists and engineers to promote national science and education goals. (4) To transfer knowledge and technological innovations and to foster productive relationships among Berkeley Lab's research programs, universities, and industry in order to promote national economic competitiveness. Berkeley Lab's research and the Laboratory Directed Research and Development (LDRD) program support DOE's Strategic Themes that are codified in DOE's 2006 Strategic Plan (DOE/CF-0010), with a primary focus on Scientific Discovery and Innovation. For that strategic theme, the Fiscal Year (FY) 2008 LDRD projects support each one of the three goals through multiple strategies described in the plan. In addition, LDRD efforts support the four goals of Energy Security, the two goals of Environmental Responsibility, and Nuclear Security (unclassified fundamental research that supports stockpile safety and nonproliferation programs). The LDRD program supports Office of Science strategic plans, including the 20-year Scientific Facilities Plan and the Office of Science Strategic Plan. The research also supports the strategic directions periodically under

  5. Laboratory Directed Research and Development Program FY 2008 Annual Report

    International Nuclear Information System (INIS)

    Hansen, Todd C.

    2009-01-01

    The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab or LBNL) is a multi-program national research facility operated by the University of California for the Department of Energy (DOE). As an integral element of DOE's National Laboratory System, Berkeley Lab supports DOE's missions in fundamental science, energy resources, and environmental quality. Berkeley Lab programs advance four distinct goals for DOE and the nation: (1) To perform leading multidisciplinary research in the computing sciences, physical sciences, energy sciences, biosciences, and general sciences in a manner that ensures employee and public safety and protection of the environment. (2) To develop and operate unique national experimental facilities for qualified investigators. (3) To educate and train future generations of scientists and engineers to promote national science and education goals. (4) To transfer knowledge and technological innovations and to foster productive relationships among Berkeley Lab's research programs, universities, and industry in order to promote national economic competitiveness. Berkeley Lab's research and the Laboratory Directed Research and Development (LDRD) program support DOE's Strategic Themes that are codified in DOE's 2006 Strategic Plan (DOE/CF-0010), with a primary focus on Scientific Discovery and Innovation. For that strategic theme, the Fiscal Year (FY) 2008 LDRD projects support each one of the three goals through multiple strategies described in the plan. In addition, LDRD efforts support the four goals of Energy Security, the two goals of Environmental Responsibility, and Nuclear Security (unclassified fundamental research that supports stockpile safety and nonproliferation programs). The LDRD program supports Office of Science strategic plans, including the 20-year Scientific Facilities Plan and the Office of Science Strategic Plan. The research also supports the strategic directions periodically under consideration and review by the

  6. Laboratory directed research and development annual report 2004

    International Nuclear Information System (INIS)

    Not Available

    2005-01-01

    This report summarizes progress from the Laboratory Directed Research and Development (LDRD) program during fiscal year 2004. In addition to a programmatic and financial overview, the report includes progress reports from 352 individual R and D projects in 15 categories. The 15 categories are: (1) Advanced Concepts; (2) Advanced Manufacturing; (3) Biotechnology; (4) Chemical and Earth Sciences; (5) Computational and Information Sciences; (6) Differentiating Technologies; (7) Electronics and Photonics; (8) Emerging Threats; (9) Energy and Critical Infrastructures; (10) Engineering Sciences; (11) Grand Challenges; (12) Materials Science and Technology; (13) Nonproliferation and Materials Control; (14) Pulsed Power and High Energy Density Sciences; and (15) Corporate Objectives

  7. RELATIONSHIP BETWEEN DIFFERENT ALLOGAMIC ASSOCIATED TRAIT CHARACTERISTICS OF THE FIVE NEWLY DEVELOPED CYTOPLASMIC MALE STERILE (CMS LINES IN RICE

    Directory of Open Access Journals (Sweden)

    Nematzadeh GHORBAN ALI

    2006-10-01

    Full Text Available Five suitable maintainer varieties were identifi ed through testcrosses with IR58025A and the transfer of wild abortive cytoplasm was carried out by seven successive backcrosses. Five new CMS lines were developed by this approach in well adapted high yielding improved varietal background such as ‘Nemat’, ‘Neda’, ‘Dasht’, ‘Amol3’ and ‘Champa’. Agronomical characterization and allogamy-associated traits of the fi ve newly developed CMS lines were studied for their interrelationship. Anther length had a signifi cant positive correlation with the duration of glume opening (0.759 and high correlation of (0.698 with the angle between lemma and palea. The results indicated that ‘Nemat’ A, ‘Neda’ A, ‘Dasht’ A are more suitable as parents for hybrid seed production due to their favorable and superior fl oral characteristics in comparison to IR58025A.

  8. Current status and future plan of JMTR Hot Laboratory

    International Nuclear Information System (INIS)

    Hoshiya, Taiji; Usui, Takashi; Saito, Jun-ichi; Shimizu, Michio; Nakakura, Yuichi; Mimura, Hideaki; Nakagawa, Tetsuya; Ooka, Norikazu

    1999-01-01

    The newly developed techniques by the Hot Laboratory (JMTR HL) have provided for us the key information on behavior of specimens due to mechanical / physical / chemical / synergistic effects of radiation, stress and water for fission and fusion reactor environment. These techniques are focused on several topics as follows; (1) miniaturized specimen test for the development of fusion reactor materials, (2) slow strain rate tensile testing (SSRT) and crack propagation measuring tests for the study of Irradiation Assisted Stress Corrosion Cracking (IASCC) of core internals of LWR, (3) handling technique on specimens including tritium for the research and development of tritium breeders and neutron multiplier as fusion blanket materials, (4) joining method using the Tungsten Inert Gas (TIG) welding technique for re-assembling of capsule and re-fabrication of specimen and (5) nondestructive evaluation using ultrasonic wave and infrared thermography for the quantitative evaluation of irradiation brittleness of key components of fission and/or fusion reactor. The mutual exchange of PIE information, interchange of researchers and mutual utilization on PIE facilities are indispensable to raise PIE potentials and to get the break-through in the study of nuclear power. (author)

  9. Developing Technical Writing Skills in the Physical Chemistry Laboratory: A Progressive Approach Employing Peer Review

    Science.gov (United States)

    Gragson, Derek E.; Hagen, John P.

    2010-01-01

    Writing formal "journal-style" lab reports is often one of the requirements chemistry and biochemistry students encounter in the physical chemistry laboratory. Helping students improve their technical writing skills is the primary reason this type of writing is a requirement in the physical chemistry laboratory. Developing these skills is an…

  10. Clinical Prediction Model for Time in Therapeutic Range While on Warfarin in Newly Diagnosed Atrial Fibrillation.

    Science.gov (United States)

    Williams, Brent A; Evans, Michael A; Honushefsky, Ashley M; Berger, Peter B

    2017-10-12

    Though warfarin has historically been the primary oral anticoagulant for stroke prevention in newly diagnosed atrial fibrillation (AF), several new direct oral anticoagulants may be preferred when anticoagulation control with warfarin is expected to be poor. This study developed a prediction model for time in therapeutic range (TTR) among newly diagnosed AF patients on newly initiated warfarin as a tool to assist decision making between warfarin and direct oral anticoagulants. This electronic medical record-based, retrospective study included newly diagnosed, nonvalvular AF patients with no recent warfarin exposure receiving primary care services through a large healthcare system in rural Pennsylvania. TTR was estimated as the percentage of time international normalized ratio measurements were between 2.0 and 3.0 during the first year following warfarin initiation. Candidate predictors of TTR were chosen from data elements collected during usual clinical care. A TTR prediction model was developed and temporally validated and its predictive performance was compared with the SAMe-TT 2 R 2 score (sex, age, medical history, treatment, tobacco, race) using R 2 and c-statistics. A total of 7877 newly diagnosed AF patients met study inclusion criteria. Median (interquartile range) TTR within the first year of starting warfarin was 51% (32, 67). Of 85 candidate predictors evaluated, 15 were included in the final validated model with an R 2 of 15.4%. The proposed model showed better predictive performance than the SAMe-TT 2 R 2 score ( R 2 =3.0%). The proposed prediction model may assist decision making on the proper mode of oral anticoagulant among newly diagnosed AF patients. However, predicting TTR on warfarin remains challenging. © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

  11. The activity of carbohydrate-degrading enzymes in the development of brood and newly emerged workers and drones of the Carniolan honeybee, Apis mellifera carnica.

    Science.gov (United States)

    Żółtowska, Krystyna; Lipiński, Zbigniew; Łopieńska-Biernat, Elżbieta; Farjan, Marek; Dmitryjuk, Małgorzata

    2012-01-01

    The activity of glycogen Phosphorylase and carbohydrate hydrolyzing enzymes α-amylase, glucoamylase, trehalase, and sucrase was studied in the development of the Carniolan honey bee, Apis mellifera carnica Pollman (Hymenoptera: Apidae), from newly hatched larva to freshly emerged imago of worker and drone. Phosphorolytic degradation of glycogen was significantly stronger than hydrolytic degradation in all developmental stages. Developmental profiles of hydrolase activity were similar in both sexes of brood; high activity was found in unsealed larvae, the lowest in prepupae followed by an increase in enzymatic activity. Especially intensive increases in activity occurred in the last stage of pupae and newly emerged imago. Besides α-amylase, the activities of other enzymes were higher in drone than in worker broods. Among drones, activity of glucoamylase was particularly high, ranging from around three times higher in the youngest larvae to 13 times higher in the oldest pupae. This confirms earlier suggestions about higher rates of metabolism in drone broods than in worker broods.

  12. Evaluating the effectiveness of a laboratory-based professional development program for science educators.

    Science.gov (United States)

    Amolins, Michael W; Ezrailson, Cathy M; Pearce, David A; Elliott, Amy J; Vitiello, Peter F

    2015-12-01

    The process of developing effective science educators has been a long-standing objective of the broader education community. Numerous studies have recommended not only depth in a teacher's subject area but also a breadth of professional development grounded in constructivist principles, allowing for successful student-centered and inquiry-based instruction. Few programs, however, have addressed the integration of the scientific research laboratory into the science classroom as a viable approach to professional development. Additionally, while occasional laboratory training programs have emerged in recent years, many lack a component for translating acquired skills into reformed classroom instruction. Given the rapid development and demand for knowledgeable employees and an informed population from the biotech and medical industries in recent years, it would appear to be particularly advantageous for the physiology and broader science education communities to consider this issue. The goal of this study was to examine the effectiveness of a laboratory-based professional development program focused on the integration of reformed teaching principles into the classrooms of secondary teachers. This was measured through the program's ability to instill in its participants elevated academic success while gaining fulfillment in the classroom. The findings demonstrated a significant improvement in the use of student-centered instruction and other reformed methods by program participants as well as improved self-efficacy, confidence, and job satisfaction. Also revealed was a reluctance to refashion established classroom protocols. The combination of these outcomes allowed for construction of an experiential framework for professional development in applied science education that supports an atmosphere of reformed teaching in the classroom. Copyright © 2015 The American Physiological Society.

  13. Confidence in leadership among the newly qualified.

    Science.gov (United States)

    Bayliss-Pratt, Lisa; Morley, Mary; Bagley, Liz; Alderson, Steven

    2013-10-23

    The Francis report highlighted the importance of strong leadership from health professionals but it is unclear how prepared those who are newly qualified feel to take on a leadership role. We aimed to assess the confidence of newly qualified health professionals working in the West Midlands in the different competencies of the NHS Leadership Framework. Most respondents felt confident in their abilities to demonstrate personal qualities and work with others, but less so at managing or improving services or setting direction.

  14. The Laboratory Notebook as a Research and Development Record

    Science.gov (United States)

    Bailey, Martha J.

    1972-01-01

    The literature concerning laboratory notebooks is reviewed. A procedure is described for administering laboratory notebooks. Outlined is an indexing system which provides a method for retrieving information by laboratory notebook number, by name, and by general subjects. The indexing scheme is estimated to be adequate for collections up to 5,000…

  15. The development of Metacognition test in genetics laboratory for undergraduate students

    Science.gov (United States)

    A-nongwech, Nattapong; Pruekpramool, Chaninan

    2018-01-01

    The purpose of this research was to develop a Metacognition test in a Genetics Laboratory for undergraduate students. The participants were 30 undergraduate students of a Rajabhat university in Rattanakosin group in the second semester of the 2016 academic year using purposive sampling. The research instrument consisted of 1) Metacognition test and 2) a Metacognition test evaluation form for experts focused on three main points which were an accurate evaluation form of content, a consistency between Metacognition experiences and questions and the appropriateness of the test. The quality of the test was analyzed by using the Index of Consistency (IOC), discrimination and reliability. The results of developing Metacognition test were summarized as 1) The result of developing Metacognition test in a Genetics Laboratory for undergraduate students found that the Metacognition test contained 56 items of open - ended questions. The test composed of 1) four scientific situations, 2) fourteen items of open - ended questions in each scientific situation for evaluating components of Metacognition. The components of Metacognition consisted of Metacognitive knowledge, which were divided into person knowledge, task knowledge and strategy knowledge and Metacognitive experience, which were divided into planning, monitoring and evaluating, and 3) fourteen items of scoring criteria divided into four scales. 2) The results of the item analysis of Metacognition in Genetics Laboratory for undergraduate students found that Index of Consistency between Metacognitive experiences and questions were in the range between 0.75 - 1.00. An accuracy of content equaled 1.00. The appropriateness of the test equaled 1.00 in all situations and items. The discrimination of the test was in the range between 0.00 - 0.73. Furthermore, the reliability of the test equaled 0.97.

  16. Abbreviated larval development of Macrobrachium inpa Kensley and Walker, 1982 (Crustacea: Decapoda: Palaemonidae from an Amazon Basin forest stream, Brazil, reared in the laboratory

    Directory of Open Access Journals (Sweden)

    Célio Magalhães

    Full Text Available Abstract This paper brings the description and illustrations of the abbreviated larval development of the Amazonian freshwater palaemonid shrimp, Macrobrachium inpa Kensley and Walker, 1982. The study was based on ovigerous females (mean total body length of 27.0 ± 1.64 mm collected in a small forest stream in the Reserva Florestal Ducke, near Manaus, Brazil, of which four released their larvae in the laboratory. The females carried 8 to 19 eliptical (2.39 ± 0.10 X 1.67 ± 0.08 mm, yolk-rich eggs. The larval period consists of three benthic, lecithotrophic larval stages, and lasts 10-11 days. The newly-hatched larvae bear very advanced morphological features such as antenna with several marginal plumose seta on scaphocerite and long, multi-articulated flagellum; fully developed, functional uniramous pereiopods 3-5 (walking legs and biramous pleopods. The morphology of the carapace, all appendages of the cephalothorax and pleon, and the tail fan are described in detail and illustrated. The larval form was considered to be a decapodid because of the benthic behavior and due to the fact that functional walking legs and pleopods are the main structures for displacement and propulsion. The larval development of M. inpa is compared with those of the so-called "continental" group of the caridean shrimps from the Amazon River basin.

  17. Point-Counterpoint: The FDA Has a Role in Regulation of Laboratory-Developed Tests.

    Science.gov (United States)

    Caliendo, Angela M; Hanson, Kimberly E

    2016-04-01

    Since the Food and Drug Administration (FDA) released its draft guidance on the regulation of laboratory-developed tests (LDTs) in October 2014, there has been a flurry of responses from commercial and hospital-based laboratory directors, clinicians, professional organizations, and diagnostic companies. The FDA defines an LDT as an "in vitrodiagnostic device that is intended for clinical use and is designed, manufactured, and used within a single laboratory." The draft guidance outlines a risk-based approach, with oversight of high-risk and moderate-risk tests being phased in over 9 years. High-risk tests would be regulated first and require premarket approval. Subsequently, moderate-risk tests would require a 510(k) premarket submission to the FDA and low-risk tests would need only to be registered. Oversight discretion would be exercised for LDTs focused on rare diseases (defined as fewer than 4,000 tests, not cases, per year nationally) and unmet clinical needs (defined as those tests for which there is no alternative FDA-cleared or -approved test). There was an open comment period followed by a public hearing in early January of 2015, and we are currently awaiting the final decision regarding the regulation of LDTs. Given that LDTs have been developed by many laboratories and are essential for the diagnosis and monitoring of an array of infectious diseases, changes in their regulation will have far-reaching implications for clinical microbiology laboratories. In this Point-Counterpoint, Angela Caliendo discusses the potential benefits of the FDA guidance for LDTs whereas Kim Hanson discusses the concerns associated with implementing the guidance and why these regulations may not improve clinical care. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

  18. Sensor development at the semiconductor laboratory of the Max-Planck-Society

    Science.gov (United States)

    Bähr, A.; Lechner, P.; Ninkovic, J.

    2017-12-01

    For more than twenty years the semiconductor laboratory of the Max-Planck Society (MPG-HLL) is developing high-performing, specialised, scientific silicon sensors including the integration of amplifying electronics on the sensor chip. This paper summarises the actual status of these devices like pnCCDs and DePFET Active Pixel Sensors and their applications.

  19. Developing a gate-array capability at a research and development laboratory

    Science.gov (United States)

    Balch, J. W.; Current, K. W.; Magnuson, W. G., Jr.; Pocha, M. D.

    1983-03-01

    Experiences in developing a gate array capability for low volume applications in a research and development (R and D) laboratory are described. By purchasing unfinished wafers and doing the customization steps in-house. Turnaround time was shortened to as little as one week and the direct costs reduced to as low as $5K per design. Designs generally require fast turnaround (a few weeks to a few months) and very low volumes (1 to 25). Design costs must be kept at a minimum. After reviewing available commercial gate array design and fabrication services, it was determined that objectives would best be met by using existing internal integrated circuit fabrication facilities, the COMPUTERVISION interactive graphics layout system, and extensive computational capabilities. The reasons and the approach taken for; selection for a particular gate array wafer, adapting a particular logic simulation program, and how layout aids were enhanced are discussed. Testing of the customized chips is described. The content, schedule, and results of the internal gate array course recently completed are discussed. Finally, problem areas and near term plans are presented.

  20. Technology roadmap for development of SiC sensors at plasma processes laboratory

    Directory of Open Access Journals (Sweden)

    Mariana Amorim Fraga

    2010-08-01

    Full Text Available Recognizing the need to consolidate the research and development (R&D activities in microelectronics fields in a strategic manner, the Plasma Processes Laboratory of the Technological Institute of Aeronautics (LPP-ITA has established a technology roadmap to serve as a guide for activities related to development of sensors based on silicon carbide (SiC thin films. These sensors have also potential interest to the aerospace field due to their ability to operate in harsh environment such as high temperatures and intense radiation. In the present paper, this roadmap is described and presented in four main sections: i introduction, ii what we have already done in the past, iii what we are doing in this moment, and iv our targets up to 2015. The critical technological issues were evaluated for different categories: SiC deposition techniques, SiC processing techniques for sensors fabrication and sensors characterization. This roadmap also presents a shared vision of how R&D activities in microelectronics should develop over the next five years in our laboratory.

  1. LABORATORY DIRECTED RESEARCH AND DEVELOPMENT ANNUAL REPORT TO THE DEPARTMENT OF ENERGY - DECEMBER 2000.

    Energy Technology Data Exchange (ETDEWEB)

    FOX,K.J.

    2000-12-31

    The goals and objectives of BNL's LDRD Program can be inferred from the Program's stated purposes. These are to (1) encourage and support the development of new ideas and technology, (2) promote the early exploration and I exploitation of creative and innovative concepts, and (3) develop new ''fundable'' R&D projects and programs. The emphasis is clearly articulated by BNL to be on supporting exploratory research ''which could lead to new programs, ,projects, and directions'' for the Laboratory. As one of the premier scientific laboratories of the DOE, BNL must continuously foster groundbreaking scientific research. At Brookhaven National Laboratory one such method is through its Laboratory Directed Research and Development Program. This discretionary research and development tool is critical in maintaining the scientific excellence and long-term vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community, fostering new science and technology ideas, which is a major factor in achieving and maintaining staff excellence and a means to address national needs within the overall mission of the DOE and BNL. The LDRD Annual Report contains summaries of all research activities funded during Fiscal Year 2000. The Project Summaries with their accomplishments described in this report reflect the above. Aside from leading to new fundable or promising programs and producing especially noteworthy research, they have resulted in numerous publications in various professional and scientific journals and presentations at meetings and forums. All FY 2000 projects are listed and tabulated in the Project Funding Table. Also included in this Annual Report in Appendix A is a summary of the proposed projects for FY 2001. The BNL LDRD budget authority by DOE in FY 2000 was $6 million. The.actual allocation totaled $5.5 million. The following sections in this report contain the management processes, peer

  2. A national laboratory/private industry cooperative research and development agreement (CRADA)

    International Nuclear Information System (INIS)

    Pritchard, D.A.

    1996-01-01

    This paper provides an overview of the history and process of establishing a cooperative research and development agreement (CRADA) between Sandia National Laboratories and Magnavox Electronic Systems Company for the design, development, and testing of a 360-degree scanning, imaging, intrusion detection sensor. The subject of the CRADA is the Advanced Exterior Sensor (AES). It is intended for exterior use at ranges from 50 to 1,500 meters and uses a combination of three sensing technologies (infrared, visible, and radar) and a new data processing method to provide low false-alarm intrusion detection and tracking combined with immediate visual assessment. The establishment of this CRADA represents a new paradigm in the cooperation between the Department of Defense, the Department of Energy, the National Laboratories and Private Industry. Although a formal document has now been executed, a CRADA is, nonetheless, primarily an agreement to work with each other to achieve goals that might otherwise be unattainable. For the DoD, a program continues in the face of uncertain funding. For the DOE, a CRADA is in place that meets congressionally mandated guidelines. For Sandia, sponsors are in agreement on requirements and synergistic funding. And for Magnavox, an opportunity is in hand to work with researchers in developing advanced security technology

  3. 75 FR 30041 - Medicare Program; Public Meeting in Calendar Year 2010 for New Clinical Laboratory Tests Payment...

    Science.gov (United States)

    2010-05-28

    ... specified list of new Clinical Procedural Terminology (CPT) codes for clinical laboratory tests in calendar... are codified at 42 CFR part 414, subpart G. A newly created Current Procedural Terminology (CPT) code..., Medicare--Hospital Insurance; and Program No. 93.774, Medicare-- Supplementary Medical Insurance Program...

  4. Laboratory directed research and development program FY 2003

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Todd

    2004-03-27

    The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab or LBNL) is a multi-program national research facility operated by the University of California for the Department of Energy (DOE). As an integral element of DOE's National Laboratory System, Berkeley Lab supports DOE's missions in fundamental science, energy resources, and environmental quality. Berkeley Lab programs advance four distinct goals for DOE and the nation: (1) To perform leading multidisciplinary research in the computing sciences, physical sciences, energy sciences, biosciences, and general sciences in a manner that ensures employee and public safety and protection of the environment. (2) To develop and operate unique national experimental facilities for qualified investigators. (3) To educate and train future generations of scientists and engineers to promote national science and education goals. (4) To transfer knowledge and technological innovations and to foster productive relationships among Berkeley Lab's research programs, universities, and industry in order to promote national economic competitiveness. In FY03, Berkeley Lab was authorized by DOE to establish a funding ceiling for the LDRD program of $15.0 M, which equates to about 3.2% of Berkeley Lab's FY03 projected operating and capital equipment budgets. This funding level was provided to develop new scientific ideas and opportunities and allow the Berkeley Lab Director an opportunity to initiate new directions. Budget constraints limited available resources, however, so only $10.1 M was expended for operating and $0.6 M for capital equipment (2.4% of actual Berkeley Lab FY03 costs). In FY03, scientists submitted 168 proposals, requesting over $24.2 M in operating funding. Eighty-two projects were funded, with awards ranging from $45 K to $500 K. These projects are summarized in Table 1.

  5. A simple and rapid identification method for newly emerged porcine Deltacoronavirus with loop-mediated isothermal amplification

    Directory of Open Access Journals (Sweden)

    Fanfan Zhang

    2017-10-01

    Full Text Available Abstract Background Porcine Deltacoronavirus (PDCoV is a newly emerged enteropathogenic coronavirus that causes diarrhea and mortality in neonatal piglets. PDCoV has spread to many countries around the world, leading to significant economic losses in the pork industry. Therefore, a rapid and sensitive method for detection of PDCoV in clinical samples is urgently needed. Results In this study, we developed a single-tube one-step reverse transcription loop-mediated isothermal amplification (RT-LAMP assay specific for nucleocapsid gene to diagnose and monitor PDCoV infections. The detection limit of RT-LAMP assay was 1 × 101 copies of PDCoV, which was approximately 100-fold more sensitive than gel-based one-step reverse transcription polymerase chain reaction (RT-PCR. This assay could specifically amplify PDCoV and had no cross amplification with porcine epidemic diarrhea virus (PEDV, transmissible gastroenteritis virus (TGEV, porcine kobuvirus (PKoV, porcine astrovirus (PAstV, porcine reproductive and respiratory syndrome virus (PRRSV, classic swine fever virus (CSFV, and porcine circovirus type 2 (PCV2. By screening a panel of clinical specimens (N = 192, this method presented a similar sensitivity with nested RT-PCR and was 1–2 log more sensitive than conventional RT-PCR in detection of PDCoV. Conclusions The RT-LAMP assay established in this study is a potentially valuable tool, especially in low-resource laboratories and filed settings, for a rapid diagnosis, surveillance, and molecular epidemiology investigation of PDCoV infections. To the best of our knowledge, this is the first work for detection of newly emerged PDCoV with LAMP technology.

  6. Simulation for evaluation of the multi-ion-irradiation Laboratory of TechnoFusion facility and its relevance for fusion applications

    International Nuclear Information System (INIS)

    Jimenez-Rey, D.; Mota, F.; Vila, R.; Ibarra, A.; Ortiz, Christophe J.; Martinez-Albertos, J.L.; Roman, R.; Gonzalez, M.; Garcia-Cortes, I.; Perlado, J.M.

    2011-01-01

    Thermonuclear fusion requires the development of several research facilities, in addition to ITER, needed to advance the technologies for future fusion reactors. TechnoFusion will focus in some of the priority areas identified by international fusion programmes. Specifically, the TechnoFusion Area of Irradiation of Materials aims at surrogating experimentally the effects of neutron irradiation on materials using a combination of ion beams. This paper justifies this approach using computer simulations to validate the multi-ion-irradiation Laboratory. The planned irradiation facility will investigate the effects of high energetic radiations on reactor-relevant materials. In a second stage, it will also be used to analyze the performance of such materials and evaluate newly designed materials. The multi-ion-irradiation Laboratory, both triple irradiation and high-energy proton irradiation, can provide valid experimental techniques to reproduce the effect of neutron damage in fusion environment.

  7. Renewable energy technology development at Sandia National Laboratories

    Science.gov (United States)

    Klimas, P. C.

    1994-02-01

    The use of renewable energy technologies is typically thought of as an integral part of creating and sustaining an environment that maximizes the overall quality of life of the Earth's present inhabitants and does not leave an undue burden on future generations. Sandia National Laboratories has been a leader in developing many of these technologies over the last two decades. This paper describes innovative solar, wind and geothermal energy systems and components that Sandia is helping to bring to the marketplace. A common but special aspect of all of these activities is that they are conducted in partnership with non-federal government entities. A number of these partners are from New Mexico.

  8. A model for mentoring newly-appointed nurse educators in nursing education institutions in South Africa

    Directory of Open Access Journals (Sweden)

    Eunice Seekoe

    2014-02-01

    Full Text Available Background: South Africa transformed higher education through the enactment of the Higher Education Act (No. 101 of 1997. The researcher identified the need to develop a model for the mentoring of newly-appointed nurse educators in nursing education institutions in South Africa. Objectives: To develop and describe the model for mentoring newly-appointed nurse educators in nursing education institutions in South Africa. Method: A qualitative and theory-generating design was used (following empirical findings regarding needs analysis in order to develop the model. The conceptualisation of the framework focused on the context, content, process and the theoretical domains that influenced the model. Ideas from different theories were borrowed from and integrated with the literature and deductive and inductive strategies were applied. Results: The structure of the model is multidimensional and complex in nature (macro, mesoand micro based on the philosophy of reflective practice, competency-based practice andcritical learning theories. The assumptions are in relation to stakeholders, context, mentoring, outcome, process and dynamic. The stakeholders are the mentor and mentee within an interactive participatory relationship. The mentoring takes place within the process with a sequence of activities such as relationship building, development, engagement, reflective process and assessment. Capacity building and empowerment are outcomes of mentoring driven by motivation. Conclusion: The implication for nurse managers is that the model can be used to develop mentoring programmes for newly-appointed nurse educators.

  9. Problems faced by newly diagnosed diabetes mellitus patients at ...

    African Journals Online (AJOL)

    Diabetes mellitus can be a frightening experience for newly diagnosed patients. The aim of this study was to determine and describe the problems faced by newly diagnosed diabetes mellitus patients at primary healthcare facilities at Mopani district, Limpopo Province. A qualitative, descriptive and contextual research ...

  10. Research and Development for Underground Science at Black Hills State University

    Science.gov (United States)

    Keeter, Kara

    2010-10-01

    The development of the Deep Underground Science and Engineering Laboratory (DUSEL) in the former Homestake mine in Lead, South Dakota has greatly spurred interest in science research and development along with education and outreach. Early science activities at Black Hills State University associated with the Sanford Underground Laboratory and DUSEL include radon emanation studies of iron oxide sludge and in situ, and radioactive background and magnetic field measurements. Work is also underway for R&D development for depleted argon-based dark matter detectors, neutrinoless double beta decay experiments, and a liquid scintillator immersion tank for whole-body low-background assays. Students from BHSU and across the state of South Dakota have been working alongside scientists on these and other projects. Teachers from high schools throughout South Dakota have also participated in these projects through the newly formed QuarkNet Center at BHSU.

  11. Development of a versatile user-friendly IBA experimental chamber

    Energy Technology Data Exchange (ETDEWEB)

    Kakuee, Omidreza; Fathollahi, Vahid; Lamehi-Rachti, Mohammad

    2016-03-15

    Reliable performance of the Ion Beam Analysis (IBA) techniques is based on the accurate geometry of the experimental setup, employment of the reliable nuclear data and implementation of dedicated analysis software for each of the IBA techniques. It has already been shown that geometrical imperfections lead to significant uncertainties in quantifications of IBA measurements. To minimize these uncertainties, a user-friendly experimental chamber with a heuristic sample positioning system for IBA analysis was recently developed in the Van de Graaff laboratory in Tehran. This system enhances IBA capabilities and in particular Nuclear Reaction Analysis (NRA) and Elastic Recoil Detection Analysis (ERDA) techniques. The newly developed sample manipulator provides the possibility of both controlling the tilt angle of the sample and analyzing samples with different thicknesses. Moreover, a reasonable number of samples can be loaded in the sample wheel. A comparison of the measured cross section data of the {sup 16}O(d,p{sub 1}){sup 17}O reaction with the data reported in the literature confirms the performance and capability of the newly developed experimental chamber.

  12. Development of a versatile user-friendly IBA experimental chamber

    Science.gov (United States)

    Kakuee, Omidreza; Fathollahi, Vahid; Lamehi-Rachti, Mohammad

    2016-03-01

    Reliable performance of the Ion Beam Analysis (IBA) techniques is based on the accurate geometry of the experimental setup, employment of the reliable nuclear data and implementation of dedicated analysis software for each of the IBA techniques. It has already been shown that geometrical imperfections lead to significant uncertainties in quantifications of IBA measurements. To minimize these uncertainties, a user-friendly experimental chamber with a heuristic sample positioning system for IBA analysis was recently developed in the Van de Graaff laboratory in Tehran. This system enhances IBA capabilities and in particular Nuclear Reaction Analysis (NRA) and Elastic Recoil Detection Analysis (ERDA) techniques. The newly developed sample manipulator provides the possibility of both controlling the tilt angle of the sample and analyzing samples with different thicknesses. Moreover, a reasonable number of samples can be loaded in the sample wheel. A comparison of the measured cross section data of the 16O(d,p1)17O reaction with the data reported in the literature confirms the performance and capability of the newly developed experimental chamber.

  13. Development of Remote Control Laboratory for Radiation Detection via Internet

    International Nuclear Information System (INIS)

    Park, Sang Tae; Lee, Hee Bok; Yuk, Keun Chul

    2002-01-01

    The role of experiments in science education is essential for understanding the natural phenomena and principle related to a subject. Therefore, the remote control experiment via Internet is one of key solution for distance learners in science education. The remote experiments are also necessary for the time-consuming experiment which takes several days, collaborative experiment between distance learners, expensive laboratory equipment which is not usually available to students, experimental procedure which is dangerous, etc. In this study, we have developed a general method for a remote control laboratory system using internet and interface techniques. It is possible for students to learn the nuclear physics to control the real instruments and conduct physics experimentation with internet techniques. We proposed the remote control radiation measurement system as a sample application. This system could be useful for the monitoring near a nuclear power plants in order to improve the environment data credibility to the public

  14. Newly graduated nurses' use of knowledge sources in clinical decision-making

    DEFF Research Database (Denmark)

    Voldbjerg, Siri Lygum; Grønkjaer, Mette; Wiechula, Rick

    2017-01-01

    AIMS AND OBJECTIVES: To explore which knowledge sources newly graduated nurses' use in clinical decision-making and why and how they are used. BACKGROUND: In spite of an increased educational focus on skills and competencies within evidence based practice newly graduated nurses' ability to use...... approaches to strengthen the knowledgebase used in clinical decision-making. DESIGN AND METHODS: Ethnographic study using participant-observation and individual semi-structured interviews of nine Danish newly graduated nurses in medical and surgical hospital settings. RESULTS: Newly graduates use...... in clinical decision-making. If newly graduates are to be supported in an articulate and reflective use of a variety of sources, they have to be allocated to experienced nurses who model a reflective, articulate and balanced use of knowledge sources. This article is protected by copyright. All rights reserved....

  15. Newly graduated nurses' occupational commitment and its associations with professional competence and work-related factors.

    Science.gov (United States)

    Numminen, Olivia; Leino-Kilpi, Helena; Isoaho, Hannu; Meretoja, Riitta

    2016-01-01

    To explore newly graduated nurses' occupational commitment and its associations with their self-assessed professional competence and other work-related factors. As a factor affecting nurse turnover, newly graduated nurses' occupational commitment and its associations with work-related factors needs exploring to retain adequate workforce. Nurses' commitment has mainly been studied as organisational commitment, but newly graduated nurses' occupational commitment and its association with work-related factors needs further studying. This study used descriptive, cross-sectional, correlation design. A convenience sample of 318 newly graduated nurses in Finland participated responding to an electronic questionnaire. Statistical software, NCSS version 9, was used in data analysis. Frequencies, percentages, ranges, means and standard deviations summarised the data. Multivariate Analyses of Variance estimated associations between occupational commitment and work-related variables. IBM SPSS Amos version 22 estimated the model fit of Occupational Commitment Scale and Nurse Competence Scale. Newly graduated nurses' occupational commitment was good, affective commitment reaching the highest mean score. There was a significant difference between the nurse groups in favour of nurses at higher competence levels in all subscales except in limited alternatives occupational commitment. Multivariate analyses revealed significant associations between subscales of commitment and competence, turnover intentions, job satisfaction, earlier professional education and work sector, competence counting only through affective dimension. The association between occupational commitment and low turnover intentions and satisfaction with nursing occupation was strong. Higher general competence indicated higher overall occupational commitment. Managers' recognition of the influence of all dimensions of occupational commitment in newly graduated nurses' professional development is important. Follow

  16. Laboratory Directed Research and Development Program. Annual report to the Department of Energy, December 1997

    Energy Technology Data Exchange (ETDEWEB)

    Ogeka, G.J.; Searing, J.M.

    1997-12-01

    New ideas and opportunities fostering the advancement of technology are occurring at an ever increasing rate. It, therefore, seems appropriate that a vehicle be available which fosters the development of new ideas and technologies, promotes the early exploration and exploitation of creative and innovative concepts, and develops new fundable R and D projects and programs if BNL is to carry out its primary mission and support the basic Department of Energy activities. At Brookhaven National Laboratory one such method is through its Laboratory Directed Research and Development Program. This discretionary research and development tool is critical in maintaining the scientific excellence and vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor in achieving and maintaining staff excellence and a means to address national needs within the overall mission of the DOE and BNL. The Project Summaries with their accomplishments described in this report reflect the above. Aside from leading to new fundable or promising programs and producing especially noteworthy research, they have resulted in numerous publications in various professional and scientific journals and presentations at meetings and forums.

  17. Laboratory Directed Research and Development Program annual report to the Department of Energy, December 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-01

    New ideas and opportunities fostering the advancement of technology are occurring at an ever increasing rate. It, therefore, seems appropriate that a vehicle be available which fosters the development of new ideas and technologies, promotes the early exploration and exploitation of creative and innovative concepts, and develops new fundable R and D projects and programs if BNL is to carry out its primary mission and support the basic Department of Energy activities. At Brookhaven National Laboratory one such method is through its Laboratory Directed Research and Development Program. This discretionary research and development tool is critical in maintaining the scientific excellence and vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor in achieving and maintaining staff excellence and a means to address national needs within the overall mission of the DOE and BNL. The Project Summaries with their accomplishments described in this report reflect the above. Aside from leading to new fundable or promising programs and producing especially noteworthy research, they have resulted in numerous publications in various professional and scientific journals and presentations at meetings and forums.

  18. Laboratory Directed Research and Development Program. Annual report to the Department of Energy, December 1997

    International Nuclear Information System (INIS)

    Ogeka, G.J.; Searing, J.M.

    1997-12-01

    New ideas and opportunities fostering the advancement of technology are occurring at an ever increasing rate. It, therefore, seems appropriate that a vehicle be available which fosters the development of new ideas and technologies, promotes the early exploration and exploitation of creative and innovative concepts, and develops new fundable R and D projects and programs if BNL is to carry out its primary mission and support the basic Department of Energy activities. At Brookhaven National Laboratory one such method is through its Laboratory Directed Research and Development Program. This discretionary research and development tool is critical in maintaining the scientific excellence and vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor in achieving and maintaining staff excellence and a means to address national needs within the overall mission of the DOE and BNL. The Project Summaries with their accomplishments described in this report reflect the above. Aside from leading to new fundable or promising programs and producing especially noteworthy research, they have resulted in numerous publications in various professional and scientific journals and presentations at meetings and forums

  19. Ethical climate and nurse competence - newly graduated nurses' perceptions.

    Science.gov (United States)

    Numminen, Olivia; Leino-Kilpi, Helena; Isoaho, Hannu; Meretoja, Riitta

    2015-12-01

    is also a need for knowledge of newly graduated nurses' views of factors which act as enhancers or barriers to positive ethical climates to develop. Interventions, continuing education courses, and discussions designed to promote positive ethical climates should be developed for managers, nurses, and multi-professional teams. © The Author(s) 2014.

  20. The Development of Virtual Laboratory Using ICT for Physics in Senior High School

    Science.gov (United States)

    Masril, M.; Hidayati, H.; Darvina, Y.

    2018-04-01

    One of the problems found in the implementation of the curriculum in 2013 is not all competency skills can be performed well. Therefore, to overcome these problems, virtual laboratory designed to improve the mastery of concepts of physics. One of the design objectives virtual laboratories is to improve the quality of education and learning in physics in high school. The method used in this study is a research method development four D model with the definition phase, design phase, development phase, and dissemination phase. Research has reached the stage of development and has been tested valid specialist. The instrument used in the research is a questionnaire consisting of: 1) the material substance; 2) The display of visual communication; 3) instructional design; 4) the use of software; and 5) Linguistic. The research results is validity in general has been a very good category (85.6), so that the design of virtual labs designed can already be used in high school.

  1. Practices influenced by policy? An exploration of newly hired science teachers at sites in South Africa and the United States

    Science.gov (United States)

    Navy, S. L.; Luft, J. A.; Toerien, R.; Hewson, P. W.

    2018-05-01

    In many parts of the world, newly hired science teachers' practices are developing in a complex policy environment. However, little is known about how newly hired science teachers' practices are enacted throughout a cycle of instruction and how these practices can be influenced by macro-, meso-, and micro-policies. Knowing how policies impact practice can result in better policies or better support for certain policies in order to enhance the instruction of newly hired teachers. This comparative study investigated how 12 newly hired science teachers at sites in South Africa (SA) and the United States (US) progressed through an instructional cycle of planning, teaching, and reflection. The qualitative data were analysed through beginning teacher competency frameworks, the cycle of instruction, and institutional theory. Data analysis revealed prevailing areas of practice and connections to levels of policy within the instructional cycle phases. There were some differences between the SA and US teachers and among first-, second-, and third-year teachers. More importantly, this study indicates that newly hired teachers are susceptible to micro-policies and are progressively developing their practice. It also shows the importance of meso-level connectors. It suggests that teacher educators and policy makers must consider how to prepare and support newly hired science teachers to achieve the shared global visions of science teaching.

  2. Teaching evidence-based practice: developing a curriculum model to foster evidence-based practice in undergraduate student nurses.

    Science.gov (United States)

    Finotto, Stefano; Carpanoni, Marika; Turroni, Elena Casadei; Camellini, Riccarda; Mecugni, Daniela

    2013-09-01

    For the nature of the Evidence-Based Practice (EBP) and its relevance to nursing, the skills that it requires should be a component in the basic Nursing degree courses. For this reason, the EBP process should be introduced early on in nursing education to develop students' independence and ability to self-learning. the aim of this study is to describe the perception that newly graduated nurses have relative to the benefits of the skills learned during the laboratory's three-year EBP in consideration of the construction of the thesis, the research of evidence and usefulness of the EBP process for the development of their professional career. A descriptive study with a sample of 300 newly graduated nurses from the Degree Course in Nursing of the University of Modena and Reggio Emilia, venue of Reggio Emilia. The data collection instrument was an anonymous questionnaire. It was possible to answer through a 10 Likert scale. The sample considers effective the research of evidence carried out (mean 6, SD 2), related to the problems of patients (mean 7, SD 2); the sample considered the skills acquired during the laboratory's three-year EBP to be useful for career development (mean 7, SD 2). the decision to include the laboratory's three-year EBP in the curriculum of the Nursing degree promotes the development of skills relating to the use of the EBP process, competence that in the literature is indicated as one of the core competencies that all health professionals should develop and maintain throughout their professional career. Copyright © 2013 Elsevier Ltd. All rights reserved.

  3. NEWLY-PACKAGED BALI TOURIST PERFORMING ARTS IN THE PERSPECTIVE OF CULTURAL STUDIES

    Directory of Open Access Journals (Sweden)

    Ni Made Ruastiti

    2012-11-01

    Full Text Available This research is focused on the newly packaged tourist performing arts; they are anew concept and seem to be different from the general tourist performing arts. They arepackaged from various components of Balinese arts and managed as large scale-touristperforming arts in terms of materials, space, and time of their performances. The researchercalls them new types of Bali tourist performing arts because how they are presented isnew and different from the traditional tourist performing arts which are simply performed.In this research, the newly-packaged performing arts are analyzed in the perspective ofcultural studies.The research was carried out at three palaces in Bali; they are Mengwi Palace inBadung regency, Anyar Palace at Kerambitan, Tabanan regency, and Banyuning Palace atBongkasa, Badung regency. There are three main problems to be discussed: firstly, how dothe tourist performing arts emerge in all the palaces? Secondly, are they related to thetourist industry developed in the palaces?, thirdly, what is the impact and meaning of themfor the sake of the palaces, society, and Balinese culture? The researcher uses a qualitativemethod and an interdisciplinary approach as characteristics of cultural studies. The theoriesused are hegemony, deconstruction, and structuration.The result shows that the tourism development at all the palaces has made the localsociety become more critical. The money-oriented economy based on the spirit of gettingbenefit has made the emergence of comodification in all sectors of life. The emergence oftourist industry at the palaces has led to the idea of showing all of the useful art and culturalpotentials which at the palaces and their surroundings. Theoretically, the palaces can bestated to have deconstructed the concept of presenting the Bali tourist performing arts into anew one, that is, “the newly packaged Bali tourist performing arts”.It has been observed that all the palaces have developed t “Newly

  4. A prospective multicenter study of venous thromboembolism in patients with newly-diagnosed high-grade glioma: hazard rate and risk factors.

    Science.gov (United States)

    Streiff, Michael B; Ye, Xiaobu; Kickler, Thomas S; Desideri, Serena; Jani, Jayesh; Fisher, Joy; Grossman, Stuart A

    2015-09-01

    Venous thromboembolism (VTE) is a common complication in patients with high-grade gliomas. The purpose of this prospective multicenter study was to determine the hazard rate of first symptomatic VTE in newly-diagnosed glioma patients and identify clinical and laboratory risk factors. On enrollment, demographic and clinical information were recorded and a comprehensive coagulation evaluation was performed. Patients were followed until death. The study end point was objectively-documented symptomatic VTE. One hundred seven patients were enrolled with a median age of 57 years (range 29-85) between June 2005 and April 2008. Ninety-one (85 %) had glioblastoma multiforme (GBM). During an average survival of 17.7 months, 26 patients (24 %) (95 % CI 17-34 %) developed VTE (hazard rate 0.15 per person-year) and 94 patients (88 %) died. Median time to VTE was 14.2 weeks post-operation (range 3-126). Patients with an initial tumor biopsy were 3.0 fold more likely to suffer VTE (p = 0.02). Patients with an elevated factor VIII activity (>147 %) were 2.1-fold more likely to develop VTE. ABO blood group, D dimer and thrombin generation were not associated with VTE. No fatal VTE occurred. VTE is a common complication in patients with newly-diagnosed high grade gliomas, particularly in the first six months after diagnosis. Patients with an initial tumor biopsy and elevated factor VIII levels are at increased risk. However, VTE was not judged to be primarily responsible for any patient deaths. Therefore, outpatient primary VTE prophylaxis remains investigational until more effective primary prophylaxis strategies and therapies for glioma are identified.

  5. Evaluating the effectiveness of a laboratory-based professional development program for science educators

    Science.gov (United States)

    Amolins, Michael Wayne

    The development of effective science educators has been a long-standing goal of the American education system. Numerous studies have suggested a breadth of professional development programs that have sought to utilize constructivist principles in order to orchestrate movement toward student-led, inquiry-based instruction. Very few, however, have addressed a missing link between the modern scientific laboratory and the traditional science classroom. While several laboratory-based training programs have begun to emerge in recent years, the skills necessary to translate this information into the classroom are rarely addressed. The result is that participants are often left without an outlet or the confidence to integrate these into their lessons. The purpose of this study was to examine the effectiveness of a laboratory-based professional development program focused on classroom integration and reformed science teaching principles. This was measured by the ability to invigorate its seven participants in order to achieve higher levels of success and fulfillment in the classroom. These participants all taught at public high schools in South Dakota, including both rural and urban locations, and taught a variety of courses. Participants were selected for this study through their participation in the Sanford Research/USD Science Educator Research Fellowship Program. Through the use of previously collected data acquired by Sanford Research, this study attempted to detail the convergence of three assessments in order to demonstrate the growth and development of its participants. First, pre- and post-program surveys were completed in order to display the personal and professional growth of its participants. Second, pre- and post-program classroom observations employing the Reformed Teaching Observation Protocol allowed for the assessment of pedagogical modifications being integrated by each participant, as well as the success of such modifications in constructively

  6. Custom software development for use in a clinical laboratory.

    Science.gov (United States)

    Sinard, John H; Gershkovich, Peter

    2012-01-01

    In-house software development for use in a clinical laboratory is a controversial issue. Many of the objections raised are based on outdated software development practices, an exaggeration of the risks involved, and an underestimation of the benefits that can be realized. Buy versus build analyses typically do not consider total costs of ownership, and unfortunately decisions are often made by people who are not directly affected by the workflow obstacles or benefits that result from those decisions. We have been developing custom software for clinical use for over a decade, and this article presents our perspective on this practice. A complete analysis of the decision to develop or purchase must ultimately examine how the end result will mesh with the departmental workflow, and custom-developed solutions typically can have the greater positive impact on efficiency and productivity, substantially altering the decision balance sheet. Involving the end-users in preparation of the functional specifications is crucial to the success of the process. A large development team is not needed, and even a single programmer can develop significant solutions. Many of the risks associated with custom development can be mitigated by a well-structured development process, use of open-source tools, and embracing an agile development philosophy. In-house solutions have the significant advantage of being adaptable to changing departmental needs, contributing to efficient and higher quality patient care.

  7. Efficacy of Intra-articular Injection of a Newly Developed Plasma Rich in Growth Factor (PRGF) Versus Hyaluronic Acid on Pain and Function of Patients with Knee Osteoarthritis: A Single-Blinded Randomized Clinical Trial.

    Science.gov (United States)

    Raeissadat, Seyed Ahmad; Rayegani, Seyed Mansoor; Ahangar, Azadeh Gharooee; Abadi, Porya Hassan; Mojgani, Parviz; Ahangar, Omid Gharooi

    2017-01-01

    Knee osteoarthritis is the most common joint disease. We aimed to compare the efficacy and safety of intra-articular injection of a newly developed plasma rich in growth factor (PRGF) versus hyaluronic acid (HA) on pain and function of patients with knee osteoarthritis. In this single-blinded randomized clinical trial, patients with symptomatic osteoarthritis of knee were assigned to receive 2 intra-articular injections of our newly developed PRGF in 3 weeks or 3 weekly injections of HA. Our primary outcome was the mean change from baseline until 2 and 6 months post intervention in scores of visual analog scale, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Lequesne index. We used analysis of variance for repeated-measures statistical test. A total of 69 patients entered final analysis. The mean age of patients was 58.2 ± 7.41 years and 81.2% were women. In particular, total WOMAC index decreased from 42.9 ± 13.51 to 26.8 ± 13.45 and 24.4 ± 16.54 at 2 and 6 months in the newly developed PRGF group (within subjects P  = .001), and from 38.8 ± 12.62 to 27.8 ± 11.01 and 27.4 ± 11.38 at 2 and 6 months in the HA group (within subjects P  = .001), respectively (between subjects P  = .631). There was no significant difference between PRGF and HA groups in patients' satisfaction and minor complications of injection, whereas patients in HA group reported significantly lower injection-induced pain. In 6 months follow up, our newly developed PRGF and HA, both are effective options to decrease pain and improvement of function in patients with symptomatic mild to moderate knee osteoarthritis.

  8. An innovative educational approach to professional development of medical laboratory scientists in Botswana

    Directory of Open Access Journals (Sweden)

    Magowe MK

    2014-04-01

    Full Text Available Mabel KM Magowe,1 Jenny H Ledikwe,2,3 Ishmael Kasvosve,1 Robert Martin,2 Kabo Thankane,3 Bazghina-werq Semo2,31Faculty of Health Sciences, University of Botswana, Gaborone, Botswana; 2Department of Global Health, University of Washington, Seattle, Washington, USA; 3Botswana International Training and Education Center for Health, Gaborone, BotswanaPurpose: To address the shortage of laboratory scientists in Botswana, an innovative, one-year academic bridging program was initiated at the University of Botswana, to advance diploma-holding laboratory technicians towards becoming laboratory scientists holding Bachelor’s degrees. An evaluation was conducted, which described the outcomes of the program and the lessons learned from this novel approach to meeting human resource needs.Methods: This was a cross-sectional, mixed-methods evaluation. Qualitative interviews were conducted with graduates of the Bachelor of Science (BSc Medical Laboratory Sciences (MLS bridging program, along with the graduates’ current supervisors, and key informants who were involved in program development or implementation. The quantitative data collected included a written questionnaire, completed by program graduates, with a retrospective pre-test/post-test survey of graduates’ confidence, in terms of key laboratory competencies.Results: The BSc MLS bridging program produced thirty-three laboratory scientists over 3 years. There was a significant increase in confidence among graduates, for specified competencies, after the program (P<0.05. Graduates reported acquiring new skills and, often, accepting new responsibilities at their former workplace, particularly in relationship to leadership and management. Five graduates enrolled in advanced degree programs. Most graduates assumed increased responsibility. However, only two graduates were promoted after completing the training program. The lessons learned include: the importance of stakeholder involvement, the need for

  9. Application of the newly developed 3D transport code r3t to selected field cases

    International Nuclear Information System (INIS)

    Rubel, A.; Fein, E.

    2006-01-01

    To model the transport of contaminants in connexion with long-term safety analyses of repositories for radioactive waste recently the numerical model r 3 t was developed. In the following first applications of r 3 t are presented. The results of modelling of the transport of zinc at the sewage treatment facility in Cape Cod, Massachusetts, and of trace elements in the frame work of the in-situ diffusion experiments DI-A and DR at the underground laboratory Mont Terri are shown. (authors)

  10. [Bioethical analysis of the use of newly dead patients in medical learning].

    Science.gov (United States)

    Gomes, Andréia Patrícia; Rego, Sergio; Palácios, Marisa; Siqueira-Batista, Rodrigo

    2010-01-01

    The purpose of this article is to carry out, a discussion on the subject of bioethics and cadavers based upon a critic review of literature. A review of literature, was made with a survey of articles between 1977 and 2007 in the sites 'Biblioteca Virtual de Saúde', PubMed and SciElo, utilizing the keywords: newly deceased patients, newly dead patients, simulators,. This was complemented by a critical evaluation of books published in the area of ethics and bioethics. The possibility to develop learning without orientation by a supervisor is doubtful.. The utilization of newly dead for learning invasive procedures is very frequent and seldom admitted. These procedures, are usually, carried out secretly, without the knowledge and consent of the family. The ethical aspects of these practices are not discussed in the practical medical education. It essential that the ethics of use of recent deceased become a necessary content of graduate education. Performance of these procedures by students should always be authorized by family members. The simulators meet the requirements of training. Discussions about the ethical and bioethical aspects cannot be separated from practical considerations during the students learning time.

  11. Demonstration of glucose-6-phosphate dehydrogenase in rat Kupffer cells by a newly-developed ultrastructural enzyme-cytochemistry

    Directory of Open Access Journals (Sweden)

    S Matsubara

    2009-06-01

    Full Text Available Although various tissue macrophages possess high glucose- 6-phosphate dehydrogenase (G6PD activity, which is reported to be closely associated with their phagocytotic/bactericidal function, the fine subcellular localization of this enzyme in liver resident macrophages (Kupffer cells has not been determined.We have investigated the subcellular localization of G6PD in Kupffer cells in rat liver, using a newly developed enzyme-cytochemical (copper-ferrocyanide method. Electron-dense precipitates indicating G6PD activity were clearly visible in the cytoplasm and on the cytosolic side of the endoplasmic reticulum of Kupffer cells. Cytochemical controls ensured specific detection of the enzymatic activity. Rat Kupffer cells abundantly possessed enzyme-cytochemically detectable G6PD activity. Kupffer cell G6PD may play a role in liver defense by delivering NADPH to NADPH-dependent enzymes. G6PD enzyme-cytochemistry may be a useful tool for the study of Kupffer cell functions.

  12. R/D and implement of temper bead welding as newly developed maintenance technique in nuclear power plant

    International Nuclear Information System (INIS)

    Hirano, Shinro; Sera, Takehiko; Chigusa, Naoki; Okimura, Koji; Nishimoto, Kazutoshi

    2011-01-01

    Japanese government has recently addressed a policy to increase capacity factor of existing nuclear PPs to achieve the goal to decrease the emission of CO 2 . Numerous preventive measures have taken in nuclear power plants to minimize the risk of unexpected long shutdown. Newly developed mitigation measures or repair methods need to be qualified to satisfy regulatory standards, before it is implemented to nuclear power plants. The qualification process needs to comply regulatory standards though it may consume time to go through each of the required steps. This paper describes such cases namely ambient temper-bead welding and clarifies the issues that need to be resolved regarding qualification process. The qualification process for new methods that has not been prescribed in regulatory standards temporarily completed by go through confirm testing by JAPEIC, RNP and issuance of no action letter in rush. Currently, the qualification process can only be applied on limited area so generalized qualification process needs to be established. (author)

  13. On the use of a laser ablation as a laboratory seismic source

    Science.gov (United States)

    Shen, Chengyi; Brito, Daniel; Diaz, Julien; Zhang, Deyuan; Poydenot, Valier; Bordes, Clarisse; Garambois, Stéphane

    2017-04-01

    Mimic near-surface seismic imaging conducted in well-controlled laboratory conditions is potentially a powerful tool to study large scale wave propagations in geological media by means of upscaling. Laboratory measurements are indeed particularly suited for tests of theoretical modellings and comparisons with numerical approaches. We have developed an automated Laser Doppler Vibrometer (LDV) platform, which is able to detect and register broadband nano-scale displacements on the surface of various materials. This laboratory equipment has already been validated in experiments where piezoelectric transducers were used as seismic sources. We are currently exploring a new seismic source in our experiments, a laser ablation, in order to compensate some drawbacks encountered with piezoelectric sources. The laser ablation source is considered to be an interesting ultrasound wave generator since the 1960s. It was believed to have numerous potential applications such as the Non-Destructive Testing (NDT) and the measurements of velocities and attenuations in solid samples. We aim at adapting and developing this technique into geophysical experimental investigations in order to produce and explore complete micro-seismic data sets in the laboratory. We will first present the laser characteristics including its mechanism, stability, reproducibility, and will evaluate in particular the directivity patterns of such a seismic source. We have started by applying the laser ablation source on the surfaces of multi-scale homogeneous aluminum samples and are now testing it on heterogeneous and fractured limestone cores. Some other results of data processing will also be shown, especially the 2D-slice V P and V S tomographic images obtained in limestone samples. Apart from the experimental records, numerical simulations will be carried out for both the laser source modelling and the wave propagation in different media. First attempts will be done to compare quantitatively the

  14. Valid methods: the quality assurance of test method development, validation, approval, and transfer for veterinary testing laboratories.

    Science.gov (United States)

    Wiegers, Ann L

    2003-07-01

    Third-party accreditation is a valuable tool to demonstrate a laboratory's competence to conduct testing. Accreditation, internationally and in the United States, has been discussed previously. However, accreditation is only I part of establishing data credibility. A validated test method is the first component of a valid measurement system. Validation is defined as confirmation by examination and the provision of objective evidence that the particular requirements for a specific intended use are fulfilled. The international and national standard ISO/IEC 17025 recognizes the importance of validated methods and requires that laboratory-developed methods or methods adopted by the laboratory be appropriate for the intended use. Validated methods are therefore required and their use agreed to by the client (i.e., end users of the test results such as veterinarians, animal health programs, and owners). ISO/IEC 17025 also requires that the introduction of methods developed by the laboratory for its own use be a planned activity conducted by qualified personnel with adequate resources. This article discusses considerations and recommendations for the conduct of veterinary diagnostic test method development, validation, evaluation, approval, and transfer to the user laboratory in the ISO/IEC 17025 environment. These recommendations are based on those of nationally and internationally accepted standards and guidelines, as well as those of reputable and experienced technical bodies. They are also based on the author's experience in the evaluation of method development and transfer projects, validation data, and the implementation of quality management systems in the area of method development.

  15. 10-GHz return-to-zero pulse source tunable in wavelength with a single- or multiwavelength output based on four-wave mixing in a newly developed highly nonlinear fiber

    DEFF Research Database (Denmark)

    Clausen, A. T.; Oxenlowe, L.; Peucheret, Christophe

    2001-01-01

    In this letter, a novel scheme for a wavelength-tunable pulse source (WTPS) is proposed and characterized. It is based on four-wave mixing (FWM) in a newly developed highly nonlinear fiber between a return-to-zero (RZ) pulsed signal at a fixed wavelength and a continuous wave probe tunable...

  16. PREVALENCE OF SLEEP DISORDERED BREATHING IN PATIENTS WITH NEWLY DIAGNOSED ACROMEGALY

    Directory of Open Access Journals (Sweden)

    U. A. Tsoy

    2014-01-01

    Full Text Available Background: Obstructive sleep disordered breathing or obstructive sleep apnea (OSA is the most common respiratory impairment in acromegaly. OSA is bound up with heightened cardiovascular mortality. Aim: Тo study frequency, features, and structure of sleep disordered breathing in patients with newly diagnosed acromegaly and to elucidate the factors influencing their development. Materials and methods: 38 patients (10 men, 28 women, median age 53 (28-76 years, median body mass index (BMI 29 (19.9-44.3 kg/m² with newly diagnosed acromegaly were recruited into the study. All subjects underwent full polysomnography (Embla N7000, Natus, USA and Remlogica software (USA. Results: Sleep disordered breathing was found in 28 (73.7% patients. OSA was revealed in all cases, in 11 (39.3% subjects it was mixed. In 10 (35.7% patients OSA was mild, in 8 (28.6% moderate, and in 10 (35.7% severe. BMI (р<0.01, disease duration (р=0.003, and insulin-like growth factor-1 (IGF-1 level (р=0.04 were different in patients without OSA and patients with moderate-to-severe OSA. No difference was found in sex (р=0.4, age (р=0.064, and growth hormone level (р=0.6. Frequency of arterial hypertension, diabetes mellitus, and other glucose metabolism impairments was the same in subjects without OSA and with severe-to-moderate OSA. Conclusion: All patients with newly diagnosed acromegaly should undergo polysomnography. BMI, disease duration, and IGF-1 level are significant risk factors for OSA development. Correlation OSA with arterial hypertension and glucose metabolism impairments needs to be further investigated.

  17. Development and evaluation of an interactive electronic laboratory manual for cooperative learning of medical histology.

    Science.gov (United States)

    Khalil, Mohammed K; Kirkley, Debbie L; Kibble, Jonathan D

    2013-01-01

    This article describes the development of an interactive computer-based laboratory manual, created to facilitate the teaching and learning of medical histology. The overarching goal of developing the manual is to facilitate self-directed group interactivities that actively engage students during laboratory sessions. The design of the manual includes guided instruction for students to navigate virtual slides, exercises for students to monitor learning, and cases to provide clinical relevance. At the end of the laboratory activities, student groups can generate a laboratory report that may be used to provide formative feedback. The instructional value of the manual was evaluated by a questionnaire containing both closed-ended and open-ended items. Closed-ended items using a five-point Likert-scale assessed the format and navigation, instructional contents, group process, and learning process. Open-ended items assessed student's perception on the effectiveness of the manual in facilitating their learning. After implementation for two consecutive years, student evaluation of the manual was highly positive and indicated that it facilitated their learning by reinforcing and clarifying classroom sessions, improved their understanding, facilitated active and cooperative learning, and supported self-monitoring of their learning. Copyright © 2013 American Association of Anatomists.

  18. Implementation of a configurable laboratory information management system for use in cellular process development and manufacturing.

    Science.gov (United States)

    Russom, Diana; Ahmed, Amira; Gonzalez, Nancy; Alvarnas, Joseph; DiGiusto, David

    2012-01-01

    Regulatory requirements for the manufacturing of cell products for clinical investigation require a significant level of record-keeping, starting early in process development and continuing through to the execution and requisite follow-up of patients on clinical trials. Central to record-keeping is the management of documentation related to patients, raw materials, processes, assays and facilities. To support these requirements, we evaluated several laboratory information management systems (LIMS), including their cost, flexibility, regulatory compliance, ongoing programming requirements and ability to integrate with laboratory equipment. After selecting a system, we performed a pilot study to develop a user-configurable LIMS for our laboratory in support of our pre-clinical and clinical cell-production activities. We report here on the design and utilization of this system to manage accrual with a healthy blood-donor protocol, as well as manufacturing operations for the production of a master cell bank and several patient-specific stem cell products. The system was used successfully to manage blood donor eligibility, recruiting, appointments, billing and serology, and to provide annual accrual reports. Quality management reporting features of the system were used to capture, report and investigate process and equipment deviations that occurred during the production of a master cell bank and patient products. Overall the system has served to support the compliance requirements of process development and phase I/II clinical trial activities for our laboratory and can be easily modified to meet the needs of similar laboratories.

  19. Application of a newly developed software program for image quality assessment in cone-beam computed tomography.

    Science.gov (United States)

    de Oliveira, Marcus Vinicius Linhares; Santos, António Carvalho; Paulo, Graciano; Campos, Paulo Sergio Flores; Santos, Joana

    2017-06-01

    The purpose of this study was to apply a newly developed free software program, at low cost and with minimal time, to evaluate the quality of dental and maxillofacial cone-beam computed tomography (CBCT) images. A polymethyl methacrylate (PMMA) phantom, CQP-IFBA, was scanned in 3 CBCT units with 7 protocols. A macro program was developed, using the free software ImageJ, to automatically evaluate the image quality parameters. The image quality evaluation was based on 8 parameters: uniformity, the signal-to-noise ratio (SNR), noise, the contrast-to-noise ratio (CNR), spatial resolution, the artifact index, geometric accuracy, and low-contrast resolution. The image uniformity and noise depended on the protocol that was applied. Regarding the CNR, high-density structures were more sensitive to the effect of scanning parameters. There were no significant differences between SNR and CNR in centered and peripheral objects. The geometric accuracy assessment showed that all the distance measurements were lower than the real values. Low-contrast resolution was influenced by the scanning parameters, and the 1-mm rod present in the phantom was not depicted in any of the 3 CBCT units. Smaller voxel sizes presented higher spatial resolution. There were no significant differences among the protocols regarding artifact presence. This software package provided a fast, low-cost, and feasible method for the evaluation of image quality parameters in CBCT.

  20. Application of a newly developed software program for image quality assessment in cone-beam computed tomography

    International Nuclear Information System (INIS)

    De Oliveira, Marcus Vinicius Linhares; Campos, Paulo Sergio Flores; Paulo, Graciano; Santos, Antonio Carvalho; Santos, Joana

    2017-01-01

    The purpose of this study was to apply a newly developed free software program, at low cost and with minimal time, to evaluate the quality of dental and maxillofacial cone-beam computed tomography (CBCT) images. A polymethyl methacrylate (PMMA) phantom, CQP-IFBA, was scanned in 3 CBCT units with 7 protocols. A macro program was developed, using the free software ImageJ, to automatically evaluate the image quality parameters. The image quality evaluation was based on 8 parameters: uniformity, the signal-to-noise ratio (SNR), noise, the contrast-to-noise ratio (CNR), spatial resolution, the artifact index, geometric accuracy, and low-contrast resolution. The image uniformity and noise depended on the protocol that was applied. Regarding the CNR, high-density structures were more sensitive to the effect of scanning parameters. There were no significant differences between SNR and CNR in centered and peripheral objects. The geometric accuracy assessment showed that all the distance measurements were lower than the real values. Low-contrast resolution was influenced by the scanning parameters, and the 1-mm rod present in the phantom was not depicted in any of the 3 CBCT units. Smaller voxel sizes presented higher spatial resolution. There were no significant differences among the protocols regarding artifact presence. This software package provided a fast, low-cost, and feasible method for the evaluation of image quality parameters in CBCT

  1. Application of a newly developed software program for image quality assessment in cone-beam computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    De Oliveira, Marcus Vinicius Linhares; Campos, Paulo Sergio Flores [Federal Institute of Bahia, Salvador (Brazil); Paulo, Graciano; Santos, Antonio Carvalho; Santos, Joana [Coimbra Health School, Polytechnic Institute of Coimbra, Coimbra (Portugal)

    2017-06-15

    The purpose of this study was to apply a newly developed free software program, at low cost and with minimal time, to evaluate the quality of dental and maxillofacial cone-beam computed tomography (CBCT) images. A polymethyl methacrylate (PMMA) phantom, CQP-IFBA, was scanned in 3 CBCT units with 7 protocols. A macro program was developed, using the free software ImageJ, to automatically evaluate the image quality parameters. The image quality evaluation was based on 8 parameters: uniformity, the signal-to-noise ratio (SNR), noise, the contrast-to-noise ratio (CNR), spatial resolution, the artifact index, geometric accuracy, and low-contrast resolution. The image uniformity and noise depended on the protocol that was applied. Regarding the CNR, high-density structures were more sensitive to the effect of scanning parameters. There were no significant differences between SNR and CNR in centered and peripheral objects. The geometric accuracy assessment showed that all the distance measurements were lower than the real values. Low-contrast resolution was influenced by the scanning parameters, and the 1-mm rod present in the phantom was not depicted in any of the 3 CBCT units. Smaller voxel sizes presented higher spatial resolution. There were no significant differences among the protocols regarding artifact presence. This software package provided a fast, low-cost, and feasible method for the evaluation of image quality parameters in CBCT.

  2. Review of Sandia National Laboratories - Albuquerque New Mexico DOE/DP Critical Skills Development Progrmas FY04.

    Energy Technology Data Exchange (ETDEWEB)

    Gorman, Anna K; Wilson, Dominique; CLARK, KATHERINE

    2005-09-01

    Sandia National Laboratories has developed a portfolio of programs to address the critical skills needs of the DP labs, as identified by the 1999 Chiles Commission Report. The goals are to attract and retain the best and the brightest students and transition them into Sandia - and DP Complex - employees. The US Department of Energy/Defense Programs University Partnerships funded ten laboratory critical skills development programs in FY04. This report provides a qualitative and quantitative evaluation of these programs and their status. 3

  3. Embedded Processor Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — The Embedded Processor Laboratory provides the means to design, develop, fabricate, and test embedded computers for missile guidance electronics systems in support...

  4. Fiber optic gyro development at the Jet Propulsion Laboratory

    Science.gov (United States)

    Goss, Willis C.

    1987-01-01

    A low-level, but continuing, fiber-gyro development activity has been carried on at the Jet Propulsion Laboratory since 1977. The activity was originated because of a recognition of the potential for low-cost high-performance gyros suitable for interplanetary spacecraft. An early decision was made to concentrate available resources on supporting the development of electrooptically active channel waveguide components which could be fabricated by mask diffusion processes. Titanium-indiffused lithium niobate waveguide components used at 0.83 micron wavelength were first tested and then abandoned because of instabilities caused by so-called optical damage. Components fabricated for use at 1.3-micron wavelength have proven to be stable. A gyro configuration concept based upon 1.3 micron channel waveguide components has evolved, and a baseline 1.3-micron all-fiber gyro has been assembled and tested.

  5. Medical laboratory scientist

    DEFF Research Database (Denmark)

    Smith, Julie; Qvist, Camilla Christine; Jacobsen, Katja Kemp

    2017-01-01

    Previously, biomarker research and development was performed by laboratory technicians working as craftsmen in laboratories under the guidance of medical doctors. This hierarchical structure based on professional boundaries appears to be outdated if we want to keep up with the high performance...... of our healthcare system, and take advantage of the vast potential of future biomarkers and personalized medicine. We ask the question; does our healthcare system benefit from giving the modern medical laboratory scientist (MLS) a stronger academic training in biomarker research, development...

  6. Federal laboratory nondestructive testing research and development applicable to industry

    Energy Technology Data Exchange (ETDEWEB)

    Smith, S.A.; Moore, N.L.

    1987-02-01

    This document presents the results of a survey of nondestructive testing (NDT) and related sensor technology research and development (R and D) at selected federal laboratories. Objective was to identify and characterize NDT activities that could be applied to improving energy efficiency and overall productivity in US manufacturing. Numerous federally supported R and D programs were identified in areas such as acoustic emissions, eddy current, radiography, computer tomography and ultrasonics. A Preliminary Findings Report was sent to industry representatives, which generated considerable interest.

  7. Secondary standards laboratories for ionizing radiation calibrations: the national laboratory interests

    International Nuclear Information System (INIS)

    Roberson, P.L.; Campbell, G.W.

    1984-11-01

    The national laboratories are probable candidates to serve as secondary standards laboratories for the federal sector. Representatives of the major Department of Energy laboratories were polled concerning attitudes toward a secondary laboratory structure. Generally, the need for secondary laboratories was recognized and the development of such a program was encouraged. The secondary laboratories should be reviewed and inspected by the National Bureau of Standards. They should offer all of the essential, and preferably additional, calibration services in the field of radiological health protection. The selection of secondary laboratories should be based on economic and geographic criteria and/or be voluntary. 1 ref., 2 tabs

  8. A genomic audit of newly-adopted autosomal STRs for forensic identification.

    Science.gov (United States)

    Phillips, C

    2017-07-01

    In preparation for the growing use of massively parallel sequencing (MPS) technology to genotype forensic STRs, a comprehensive genomic audit of 73 STRs was made in 2016 [Parson et al., Forensic Sci. Int. Genet. 22, 54-63]. The loci examined included miniSTRs that were not in widespread use, but had been incorporated into MPS kits or were under consideration for this purpose. The current study expands the genomic analysis of autosomal STRs that are not commonly used, to include the full set of developed miniSTRs and an additional 24 STRs, most of which have been recently included in several supplementary forensic multiplex kits for capillary electrophoresis. The genomic audit of these 47 newly-adopted STRs examined the linkage status of new loci on the same chromosome as established forensic STRs; analyzed world-wide population variation of the newly-adopted STRs using published data; assessed their forensic informativeness; and compiled the sequence characteristics, repeat structures and flanking regions of each STR. A further 44 autosomal STRs developed for forensic analyses but not incorporated into commercial kits, are also briefly described. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Combustion Research Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — The Combustion Research Laboratory facilitates the development of new combustion systems or improves the operation of existing systems to meet the Army's mission for...

  10. New developments in digital pathology: from telepathology to virtual pathology laboratory.

    Science.gov (United States)

    Kayser, Klaus; Kayser, Gian; Radziszowski, Dominik; Oehmann, Alexander

    2004-01-01

    To analyse the present status and future development of computerized diagnostic pathology in terms of work-flow integrative telepathology and virtual laboratory. Telepathology has left its childhood. The technical development of telepathology is mature, in contrast to that of virtual pathology. Two kinds of virtual pathology laboratories are emerging: a) those with distributed pathologists and distributed (>=1) laboratories associated to individual biopsy stations/surgical theatres, and b) distributed pathologists working in a centralized laboratory. Both are under technical development. Telepathology can be used for e-learning and e-training in pathology, as exemplarily demonstrated on Digital Lung Pathology Pathology (www.pathology-online.org). A virtual pathology institution (mode a) accepts a complete case with the patient's history, clinical findings, and (pre-selected) images for first diagnosis. The diagnostic responsibility is that of a conventional institution. The internet serves as platform for information transfer, and an open server such as the iPATH (http://telepath.patho.unibas.ch) for coordination and performance of the diagnostic procedure. The size of images has to be limited, and usual different magnifications have to be used. A group of pathologists is "on duty", or selects one member for a predefined duty period. The diagnostic statement of the pathologist(s) on duty is retransmitted to the sender with full responsibility. First experiences of a virtual pathology institution group working with the iPATH server (Dr. L. Banach, Dr. G. Haroske, Dr. I. Hurwitz, Dr. K. Kayser, Dr. K.D. Kunze, Dr. M. Oberholzer,) working with a small hospital of the Salomon islands are promising. A centralized virtual pathology institution (mode b) depends upon the digitalisation of a complete slide, and the transfer of large sized images to different pathologists working in one institution. The technical performance of complete slide digitalisation is still under

  11. Observation of the bone mineral density of newly formed bone using rabbits. Compared with newly formed bone around implants and cortical bone

    International Nuclear Information System (INIS)

    Nakada, Hiroshi; Numata, Yasuko; Sakae, Toshiro; Tamaki, Hiroyuki; Kato, Takao

    2009-01-01

    There have been many studies reporting that newly formed bone around implants is spongy bone. However, although the morphology is reported as being like spongy bone, it is difficult to discriminate whether the bone quality of newly formed bone appears similar to osteoid or cortical bone; therefore, evaluation of bone quality is required. The aims of this study were to measure the bone mineral density (BMD) values of newly formed bone around implants after 4, 8, 16, 24 and 48 weeks, to represent these values on three-dimensional color mapping (3Dmap), and to evaluate the change in bone quality associated with newly formed bone around implants. The animal experimental protocol of this study was approved by the Ethics Committee for Animal Experiments of our University. This experiment used 20 surface treatment implants (Ti-6Al-4V alloy: 3.1 mm in diameter and 30.0 mm in length) by grit-blasting. They were embedded into surgically created flaws in femurs of 20 New Zealand white rabbits (16 weeks old, male). The rabbits were sacrificed with an ear intravenous overdose of pentobarbital sodium under general anesthesia each period, and the femurs were resected. We measured BMD of newly formed bone around implants and cortical bone using Micro-CT, and the BMD distribution map of 3Dmap (TRI/3D Bon BMD, Ratoc System Engineering). The BMD of cortical bone was 1,026.3±44.3 mg/cm 3 at 4 weeks, 1,023.8±40.9 mg/cm 3 at 8 weeks, 1,048.2±45.6 mg/cm 3 at 16 weeks, 1,067.2±60.2 mg/cm 3 at 24 weeks, and 1,069.3±50.7 mg/cm 3 at 48 weeks after implantation, showing a non-significant increase each period. The BMD of newly formed bone around implants was 296.8±25.6 mg/cm 3 at 4 weeks, 525.0±72.4 mg/cm 3 at 8 weeks, 691.2±26.0 mg/cm 3 at 16 weeks, 776.9±27.7 mg/cm 3 at 24 weeks, and 845.2±23.1 mg/cm 3 at 48 weeks after implantation, showing a significant increase after each period. It was revealed that the color scale of newly formed bone was Low level at 4 weeks, and then it

  12. Basic Evaluation of the Newly Developed "Lias Auto P-FDP" Assay and the Influence of Plasmin-α2 Plasmin Inhibitor Complex Values on Discrepancy in the Comparison with "Lias Auto D-Dimer Neo" Assay.

    Science.gov (United States)

    Kumano, Osamu; Ieko, Masahiro; Komiyama, Yutaka; Naito, Sumiyoshi; Yoshida, Mika; Takahashi, Nobuhiko; Ohmura, Kazumasa; Hayasaki, Junki; Hayakawa, Mineji

    2018-04-01

    Laboratory determination of fibrin/fibrinogen degradation products (FDP) levels, along with that of the D-dimer, is important for assessing the fibrinolytic situation. Recently, we developed a new FDP reagent "Lias Auto P-FDP", which can detect various FDP fragments. The purpose of this study was to evaluate the basic performance of the newly developed Lias Auto P-FDP and compare it with Lias Auto D-Dimer Neo assay. The within-run precision of Lias Auto P-FDP and Lias Auto D-Dimer was determined 20 times in low and high value controls. The between-day precision was evaluated five times a day for five days. The linearity study was performed by diluting high value samples for 2 - 10-fold and 2 - 8-fold. The comparative study was performed using 172 patient samples with elevated FDP values. For the discrepancy analysis, the samples were divided into three groups by the discrepancy percentage between the FDP and D-dimer values. The groups were defined as follows: lower discrepancy group, less than -20%; no discrepancy group, -20% to 20%; upper discrepancy group, more than 20%. The coefficient of variation % (CV%) in within-run and between-day precision were within 3.8% for both FDP and the D-dimer. The correlation coefficients were more than 0.999 and the linearity was high. In the comparative study, the values of FDP were higher than that of the D-dimer in all samples. The median FDP and D-dimer values of lower discrepancy, no discrepancy, and upper discrepancy groups were 11.8, 20.3, and 51.4, and 8.0, 11.3, and 13.1, respectively. FDP showed an increasing tendency but D-Dimer showed constant values. Thus, the possible cause of discrepancy between FDP and D-dimer values were the elevated FDP values. In addition, the values of plasmin-α2 plasmin inhibitor complex (PIC) in the upper discrepancy group were higher than that of the lower and no discrepancy groups, indicating progression of fibrinolysis. In this study, we evaluated the newly developed Lias Auto P

  13. Laboratory quality assurance

    International Nuclear Information System (INIS)

    Delvin, W.L.

    1977-01-01

    The elements (principles) of quality assurance can be applied to the operation of the analytical chemistry laboratory to provide an effective tool for indicating the competence of the laboratory and for helping to upgrade competence if necessary. When used, those elements establish the planned and systematic actions necessary to provide adequate confidence in each analytical result reported by the laboratory (the definition of laboratory quality assurance). The elements, as used at the Hanford Engineering Development Laboratory (HEDL), are discussed and they are qualification of analysts, written methods, sample receiving and storage, quality control, audit, and documentation. To establish a laboratory quality assurance program, a laboratory QA program plan is prepared to specify how the elements are to be implemented into laboratory operation. Benefits that can be obtained from using laboratory quality assurance are given. Experience at HEDL has shown that laboratory quality assurance is not a burden, but it is a useful and valuable tool for the analytical chemistry laboratory

  14. Recent developments at the high-field laboratory of Tohoku University

    International Nuclear Information System (INIS)

    Motokawa, M.; Watanabe, K.; Miura, S.; Awaji, S.; Nojiri, H.; Mogi, I.; Mitsudo, S.; Sakon, T.

    1998-01-01

    Recent developments and experiments performed at the high-field laboratory of Tohoku University are described. We have (1) hybrid magnets which produce high fields up to 31.1 T, (2) liquid-helium-free superconducting magnets up to 11 T which are available continuously for more than a year, (3) a 20 T superconducting magnet, (4) pulsed field magnets up to 40 T by a 100 kJ bank and (5) repeating pulsed field systems up to 25 T, synchronized with a pulsed neutron source

  15. Geometric Design Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — Purpose: The mission of the Geometric Design Laboratory (GDL) is to support the Office of Safety Research and Development in research related to the geometric design...

  16. Department of Energy Multiprogram Laboratories

    International Nuclear Information System (INIS)

    1982-09-01

    Volume III includes the following appendices: laboratory goals and missions statements; laboratory program mix; class waiver of government rights in inventions arising from the use of DOE facilities by or for third party sponsors; DOE 4300.2: research and development work performed for others; procedure for new work assignments at R and D laboratories; and DOE 5800.1: research and development laboratory technology transfer program

  17. Newly developed central diabetes insipidus following kidney transplantation: a case report.

    Science.gov (United States)

    Kim, K M; Kim, S M; Lee, J; Lee, S Y; Kwon, S K; Kim, H-Y

    2013-09-01

    Polyuria after kidney transplantation is a common, usually self-limiting disorder. However, persistent polyuria can cause not only patient discomfort, including polyuria and polydipsia, but also volume depletion that can produce allograft dysfunction. Herein, we have report a case of central diabetes insipidus newly diagnosed after kidney transplantation. A 45-year-old woman with end-stage kidney disease underwent deceased donor kidney transplantation. Two months after the transplantation, she was admitted for persistent polyuria, polydipsia, and nocturia with urine output of more than 4 L/d. Urine osmolarity was 100 mOsm/kg, which implied that the polyuria was due to water rather than solute diuresis. A water deprivation test was compatible with central diabetes insipidus; desmopressin treatment resulted in immediate symptomatic relief. Brain magnetic resonance imaging (MRI) demonstrated diffuse thickening of the pituitary stalk, which was considered to be nonspecific finding. MRI 12 months later showed no change in the pituitary stalk, although the patient has been in good health without polyuria or polydipsia on desmopressin treatment. The possibility of central diabetes insipidus should be considered in patients presenting with persistent polyuria after kidney transplantation. Copyright © 2013 Elsevier Inc. All rights reserved.

  18. Newly graduated nurses' use of knowledge sources: a meta-ethnography.

    Science.gov (United States)

    Voldbjerg, Siri Lygum; Grønkjaer, Mette; Sørensen, Erik Elgaard; Hall, Elisabeth O C

    2016-08-01

    To advance evidence on newly graduated nurses' use of knowledge sources. Clinical decisions need to be evidence-based and understanding the knowledge sources that newly graduated nurses use will inform both education and practice. Qualitative studies on newly graduated nurses' use of knowledge sources are increasing though generated from scattered healthcare contexts. Therefore, a metasynthesis of qualitative research on what knowledge sources new graduates use in decision-making was conducted. Meta-ethnography. Nineteen reports, representing 17 studies, published from 2000-2014 were identified from iterative searches in relevant databases from May 2013-May 2014. Included reports were appraised for quality and Noblit and Hare's meta-ethnography guided the interpretation and synthesis of data. Newly graduated nurses' use of knowledge sources during their first 2-year postgraduation were interpreted in the main theme 'self and others as knowledge sources,' with two subthemes 'doing and following' and 'knowing and doing,' each with several elucidating categories. The metasynthesis revealed a line of argument among the report findings underscoring progression in knowledge use and perception of competence and confidence among newly graduated nurses. The transition phase, feeling of confidence and ability to use critical thinking and reflection, has a great impact on knowledge sources incorporated in clinical decisions. The synthesis accentuates that for use of newly graduated nurses' qualifications and skills in evidence-based practice, clinical practice needs to provide a supportive environment which nurtures critical thinking and questions and articulates use of multiple knowledge sources. © 2016 John Wiley & Sons Ltd.

  19. Laboratory investigations: Low Earth orbit environment chemistry with spacecraft surfaces

    Science.gov (United States)

    Cross, Jon B.

    1990-01-01

    Long-term space operations that require exposure of material to the low earth orbit (LEO) environment must take into account the effects of this highly oxidative atmosphere on material properties and the possible contamination of the spacecraft surroundings. Ground-based laboratory experiments at Los Alamos using a newly developed hyperthermal atomic oxygen (AO) source have shown that not only are hydrocarbon based materials effected but that inorganic materials such as MoS2 are also oxidized and that thin protective coatings such as Al2O3 can be breached, producing oxidation of the underlying substrate material. Gas-phase reaction products, such as SO2 from oxidation of MoS2 and CO and CO2 from hydrocarbon materials, have been detected and have consequences in terms of spacecraft contamination. Energy loss through gas-surface collisions causing spacecraft drag has been measured for a few select surfaces and has been found to be highly dependent on the surface reactivity.

  20. The nanotoxicology of a newly developed zero-valent iron nanomaterial for groundwater remediation and its remediation efficiency assessment combined with in vitro bioassays for detection of dioxin-like environmental pollutants

    OpenAIRE

    Schiwy, Andreas Herbert

    2016-01-01

    The assessment of chemicals and new compounds is an important task of ecotoxicology. In this thesis a newly developed zero-valent iron material for nanoremediation of groundwater contaminations was investigated and in vitro bioassays for high throughput screening were developed. These two elements of the thesis were combined to assess the remediation efficiency of the nanomaterial on the groundwater contaminant acridine. The developed in vitro bioassays were evaluated for quantification of th...

  1. In situ vitrification application to buried waste: Interim report of intermediate field tests at Idaho National Engineering Laboratory

    International Nuclear Information System (INIS)

    Callow, R.A.; Weidner, J.R.; Thompson, L.E.

    1991-02-01

    This report describes the two in situ vitrification field tests conducted in June and July 1990 at Idaho National Engineering Laboratory. In situ vitrification, an emerging technology for in- place conversion of contaminated soils into a durable glass and crystalline waste form, is being investigated as a potential remediation technology for buried waste. The overall objective of the two tests was to assess the general suitability of the process to remediate waste structures representative of buried waste found at Idaho National engineering Laboratory. In particular, these tests, as part of a treatability study, were designed to provide essential information on the field performance of the process under conditions of significant combustible and metal wastes and to test a newly developed electrode feed technology. The tests were successfully completed, and the electrode feed technology successfully processed the high metal content waste, indicating the process is a feasible technology for application to buried waste

  2. In situ vitrification application to buried waste: Interim report of intermediate field tests at Idaho National Engineering Laboratory

    International Nuclear Information System (INIS)

    Callow, R.A.; Weidner, J.R.; Thompson, L.E.

    1991-01-01

    This report describes the two in situ vitrification field tests conducted in July and July 1990 at Idaho National Engineering Laboratory. In situ vitrification, an emerging technology for in-place conversion of contaminated soils into a durable glass and crystalline waste form, is being investigated as a potential remediation technology for buried waste. The overall objective of the two tests was to assess the general suitability of the process to remediate waste structures representative of buried waste found at Idaho National Engineering Laboratory. In particular, these tests, as part of a treatability study, were designed to provide essential information field performance of the process under conditions of significant combustible and metal wastes and to test a newly developed electrode feed technology. The tests were successfully completed, and the electrode feed technology successfully processed the high metal content waste, indicating the process is a feasible technology for application to buried waste. 8 refs., 91 figs., 13 tabs

  3. In situ vitrification application to buried waste: Final report of intermediate field tests at Idaho National Engineering Laboratory

    International Nuclear Information System (INIS)

    Callow, R.A.; Weidner, J.R.; Loehr, C.A.; Bates, S.O.; Thompson, L.E.; McGrail, B.P.

    1991-08-01

    This report describes two in situ vitrification field tests conducted on simulated buried waste pits during June and July 1990 at the Idaho National Engineering Laboratory. In situ vitrification, an emerging technology for in place conversion of contaminated soils into a durable glass and crystalline waste form, is being investigated as a potential remediation technology for buried waste. The overall objective of the two tests was to access the general suitability of the process to remediate waste structures representative of buried waste found at Idaho National Engineering Laboratory. In particular, these tests, as part of a treatability study, were designed to provide essential information on the field performance of the process under conditions of significant combustible and metal wastes and to test a newly developed electrode feed technology. The tests were successfully completed, and the electrode feed technology successfully processed the high metal content waste. Test results indicate the process is a feasible technology for application to buried waste. 33 refs., 109 figs., 39 tabs

  4. A Virtual Embedded Microcontroller Laboratory for Undergraduate Education: Development and Evaluation

    Science.gov (United States)

    Richardson, Jeffrey J.; Adamo-Villani, Nicoletta

    2010-01-01

    Laboratory instruction is a major component of the engineering and technology undergraduate curricula. Traditional laboratory instruction is hampered by several factors including limited access to resources by students and high laboratory maintenance cost. A photorealistic 3D computer-simulated laboratory for undergraduate instruction in…

  5. Adding Vectors across the North: Development of Laboratory Component of Distance Education Physics Course

    Science.gov (United States)

    Spencer, V. K.; Solie, D. J.

    2010-12-01

    Bush Physics for the 21st Century (BP21) is a distance education physics course offered through the Interior Aleutians Campus of the University of Alaska Fairbanks. It provides an opportunity for rural Alaskan high school and community college students, many of whom have no other access to advanced science courses, to earn university science credit. The curriculum is mathematically rigorous and includes a laboratory component to prepare students who wish to pursue science and technology careers. The laboratory component has been developed during the past 3 years. Students learn lab safety, basic laboratory technique, experiment components and group collaboration. Experiments have place-based themes and involve skills that translate to rural Alaska when possible. Preliminary data on the general effectiveness of the labs have been analyzed and used to improve the course.

  6. An overview of the waste characterization program at Chalk River Nuclear Laboratories

    International Nuclear Information System (INIS)

    Csullog, G.W.; Hardy, D.G.

    1988-01-01

    In the last five years, Chalk River Nuclear Laboratories (CRNL) placed 17,000 m 3 of wastes into storage (excluding contaminated soil and fill). Almost half of the waste was generated off-site. CRNL is now developing IRUS, an Intrusion Resistant Underground Structure, and the IST, an Improved Sand Trench, to replace storage with safe, permanent disposal. IRUS will be used to dispose of wastes with radiologically hazardous lifetimes between 150 and 500 years duration and the IST will be used for wastes with radiologically hazardous lifetimes of less than 150 years. A comprehensive Waste Characterization Program (WCP) is in place to support disposal projects. The WCP is responsible for (1) specifying the manifests for waste shipments; (2) developing and maintaining central databases for waste inventories and analytical data; and (3) developing the technologies and procedures to characterize the radiological and the physical/chemical properties of wastes. WCP work is being performed under the umbrella of a newly developed waste management quality assurance (QA) program. This paper gives an overview of the WCP with an emphasis on the requirements for determining radionuclide inventories in wastes, for implementing record-keeping systems and for maintaining a QA program for disposal operations

  7. Process in Developing Zebra fish Laboratory at Malaysian Nuclear Agency for Toxicology Studies

    International Nuclear Information System (INIS)

    Fazliana Mohd Saaya; Mohd Noor Hidayat Adenan; Anee Suryani Sued

    2015-01-01

    Toxicology is a branch of the very important especially in determining the safety and effectiveness of herbal products to avoid any side effects to the user. Currently, toxicity tests conducted in the laboratory is testing the toxicity of shrimp, tests on cell cultures and experimental animal tests on the rats. One of the most recent exam easier and can reduce the use of experimental rats was testing on zebra fish fish. Fish zebra fish Danio rerio, suitable for the study of toxicity, teratogenicity, genetic, oncology and neurobiology. Zebra fish system of aquarium fish zebra fish system has been in Nuclear Malaysia since 2013 but has not yet fully operational due to several factors and is in the process of moving into a new laboratory which systematically and in accordance with the enabling environment for care. The development of a new fully equipped laboratory is expected to benefit all for use in research. (author)

  8. Newly blind persons using virtual environment system in a traditional orientation and mobility rehabilitation program: a case study.

    Science.gov (United States)

    Lahav, Orly; Schloerb, David W; Srinivasan, Mandayam A

    2012-09-01

    This paper presents a virtual reality system (the BlindAid) developed for orientation and mobility training of people who are newly blind. The BlindAid allows users to interact with different virtual structures and objects via auditory and haptic feedback. This case study aims to examine if and how the BlindAid, in conjunction with a traditional rehabilitation programme, can help people who are newly blind develop new orientation and mobility methods. Follow-up research based on this study, with a large experiment and control group, could contribute to the area of orientation and mobility rehabilitation training for the newly blind. The case study research focused on A., a woman who is newly blind, for 17 virtual sessions spanning ten weeks, during the 12 weeks of her traditional orientation and mobility rehabilitation programme. The research was implemented by using virtual environment (VE) exploration and orientation tasks in VE and physical spaces. The research methodology used both qualitative and quantitative methods, including interviews, questionnaire, videotape recording, and user computer logs. The results of this study helped elucidate several issues concerning the contribution of the BlindAid system to the exploration strategies and learning processes experienced by the participant in her encounters with familiar and unfamiliar physical surroundings. [Box: see text].

  9. Protective Systems Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — This laboratory is a 40 by 28 by 9 foot facility that is equipped with tools for the development of various items of control technology related to the transmission...

  10. The impact of organisational culture on the adaptation of newly ...

    African Journals Online (AJOL)

    Usually newly employed nurses find adjusting to a work setting a challenging experience. Their successful adaptation to their work situation is greatly influenced by the socialisation process inherent in the organisational culture. The newly employed nurse often finds that the norms are unclear, confusing and restrictive.

  11. A newly developed spinal simulator.

    Science.gov (United States)

    Chester, R; Watson, M J

    2000-11-01

    A number of studies indicate poor intra-therapist and inter-therapist reliability in the performance of graded, passive oscillatory movements to the lumbar spine. However, it has been suggested that therapists can be trained to be more consistent in their performance of these techniques if given reliable quantitative feedback. The intention of this study was to develop equipment, analogous to the lumbar spine that could be used for both teaching and research purposes. Equipment has been updated and connected to a personal IBM compatible computer. Custom designed software allows concurrent and accurate feedback to students on their performance and in a form suitable for advanced data analysis using statistical packages. The uses and implications of this equipment are discussed. Copyright 2000 Harcourt Publishers Ltd.

  12. Encounters of Newly Qualified Teachers with Micro-Politics in Primary Schools in Zimbabwe

    Science.gov (United States)

    Magudu, Snodia; Gumbo, Mishack

    2017-01-01

    This article demonstrates, through the example of Zimbabwe, the complexities of micro-political learning during induction. It reports on the experiences of ten newly qualified teachers with micro-politics or power relations in their schools during induction and locates these experiences within the broader context of their professional development.…

  13. The construction of social identity in newly recruited nuclear engineering staff: A longitudinal study

    International Nuclear Information System (INIS)

    Nguyen, Lynda; Murphy, Glen; Chang, Artemis

    2014-01-01

    This study examines the process by which newly recruited nuclear engineering and technical staff came to understand, define, think, feel and behave within a distinct group that has a direct contribution to the organization's overall emphasis on a culture of reliability and system safety. In the field of organizational behavior the interactive model of social identity formation has been recently proposed to explain the process by which the internalization of shared norms and values occurs, an element critical in identity formation. Using this rich model of organizational behavior we analyzed multiple sources of data from nine new hires over a period of three years. This was done from the time they were employed to investigate the construction of social identity by new entrants entering into a complex organizational setting reflected in the context of a nuclear facility. Informed by our data analyses, we found support for the interactive model of social identity development and report the unexpected finding that a newly appointed member's age and level of experience appears to influence the manner in which they adapt, and assimilate into their surroundings. This study represents an important contribution to the safety and reliability literature as it provides a rich insight into the way newly recruited employees enact the process by which their identities are formed and hence act, particularly under conditions of duress or significant organizational disruption in complex organizational settings. - Highlights: • We examined how newly recruited nuclear engineer staff develop their social identity. • The study empirically examined the interactive model of social identity formation. • Innovative research strategies were used to capture rich primary data for all case studies. • Age and experience moderated internalization route and the social identity formation process

  14. Annual report on operation, utilization and technical development of research reactors and hot laboratory

    International Nuclear Information System (INIS)

    1990-09-01

    This report describes the activities of the Department of Research Reactor Operation in fiscal year of 1989. It also presents some technical topics on the reactor operation and utilization in details. The Department is responsible for operation of the research reactors, JRR-2 and JRR-4, and the Hot Laboratory. The research reactor JRR-3 was reconstructed to enhance the performance for utilization. The first criticality was achieved on March 22, 1989, and it subsequently went into operation. In connection with the reactor operation, the various research and development activities in the area of fuel management, water chemistry, radiation monitoring and material irradiation have been made. In the Hot Laboratory, post-irradiation examinations of fuels and materials have been carried out along with the development of related techniques. (author)

  15. Siberian Chemical Combine laboratory project work plan, fiscal year 1999

    International Nuclear Information System (INIS)

    Morgado, R.E.; Acobyan, R.; Shropsire, R.

    1998-01-01

    The Siberian Chemical Combine (SKhK), Laboratory Project Work Plan (Plan) is intended to assist the US Laboratory Project Team, and Department of Energy (DOE) staff with the management of the FY99 joint material protection control and accounting program (MPC and A) for enhancing nuclear material safeguards within the Siberian Chemical Combine. The DOE/Russian/Newly Independent States, Nuclear Material Task Force, uses a project work plan document for higher-level program management. The SKhK Plan is a component of the Russian Defense related Sites' input to that document. In addition, it contains task descriptions and a Gantt Chart covering the FY99 time-period. This FY99 window is part of a comprehensive, Project Status Gantt Chart for tasking and goal setting that extends to the year 2003. Secondary and tertiary levels of detail are incorporated therein and are for the use of laboratory project management. The SKhK Plan is a working document, and additions and modifications will be incorporated as the MPC and A project for SKhK evolves

  16. Assessment for markers of nephropathy in newly diagnosed type 2 ...

    African Journals Online (AJOL)

    Objective: To assess for markers of nephropathy in newly diagnosed type 2 diabetics, using blood pressure levels, endogenous creatinine clearance and urinary protein excretion as markers of renal disease. Study design: Ninety newly diagnosed type 2 diabetics were studied within 6 weeks of diagnosis. They were in ...

  17. Survey and analysis of materials research and development at selected federal laboratories

    Energy Technology Data Exchange (ETDEWEB)

    Reed, J.E.; Fink, C.R.

    1984-04-01

    This document presents the results of an effort to transfer existing, but relatively unknown, materials R and D from selected federal laboratories to industry. More specifically, recent materials-related work at seven federal laboratories potentially applicable to improving process energy efficiency and overall productiviy in six energy-intensive manufacturing industries was evaluated, catalogued, and distributed to industry representatives to gauge their reaction. Laboratories surveyed include: Air Force Wright Aeronautical Laboratories Material Laboratory (AFWAL). Pacific Northwest Laboratory (PNL), National Aeronautics and Space Administration Marshall Flight Center (NASA Marshall), Oak Ridge National Laboratory (ORNL), Brookhaven National Laboratory (BNL), Idaho National Engineering Laboratory (INEL), and Jet Propulsion Laboratory (JPL). Industries included in the effort are: aluminum, cement, paper and allied products, petroleum, steel and textiles.

  18. Efficacy of Intra-articular Injection of a Newly Developed Plasma Rich in Growth Factor (PRGF) Versus Hyaluronic Acid on Pain and Function of Patients with Knee Osteoarthritis: A Single-Blinded Randomized Clinical Trial

    Science.gov (United States)

    Raeissadat, Seyed Ahmad; Rayegani, Seyed Mansoor; Ahangar, Azadeh Gharooee; Abadi, Porya Hassan; Mojgani, Parviz; Ahangar, Omid Gharooi

    2017-01-01

    Background and objectives: Knee osteoarthritis is the most common joint disease. We aimed to compare the efficacy and safety of intra-articular injection of a newly developed plasma rich in growth factor (PRGF) versus hyaluronic acid (HA) on pain and function of patients with knee osteoarthritis. Methods: In this single-blinded randomized clinical trial, patients with symptomatic osteoarthritis of knee were assigned to receive 2 intra-articular injections of our newly developed PRGF in 3 weeks or 3 weekly injections of HA. Our primary outcome was the mean change from baseline until 2 and 6 months post intervention in scores of visual analog scale, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Lequesne index. We used analysis of variance for repeated-measures statistical test. Results: A total of 69 patients entered final analysis. The mean age of patients was 58.2 ± 7.41 years and 81.2% were women. In particular, total WOMAC index decreased from 42.9 ± 13.51 to 26.8 ± 13.45 and 24.4 ± 16.54 at 2 and 6 months in the newly developed PRGF group (within subjects P = .001), and from 38.8 ± 12.62 to 27.8 ± 11.01 and 27.4 ± 11.38 at 2 and 6 months in the HA group (within subjects P = .001), respectively (between subjects P = .631). There was no significant difference between PRGF and HA groups in patients’ satisfaction and minor complications of injection, whereas patients in HA group reported significantly lower injection-induced pain. Conclusions: In 6 months follow up, our newly developed PRGF and HA, both are effective options to decrease pain and improvement of function in patients with symptomatic mild to moderate knee osteoarthritis. PMID:29051707

  19. Efficacy of Intra-articular Injection of a Newly Developed Plasma Rich in Growth Factor (PRGF Versus Hyaluronic Acid on Pain and Function of Patients with Knee Osteoarthritis: A Single-Blinded Randomized Clinical Trial

    Directory of Open Access Journals (Sweden)

    Seyed Ahmad Raeissadat

    2017-10-01

    Full Text Available Background and objectives: Knee osteoarthritis is the most common joint disease. We aimed to compare the efficacy and safety of intra-articular injection of a newly developed plasma rich in growth factor (PRGF versus hyaluronic acid (HA on pain and function of patients with knee osteoarthritis. Methods: In this single-blinded randomized clinical trial, patients with symptomatic osteoarthritis of knee were assigned to receive 2 intra-articular injections of our newly developed PRGF in 3 weeks or 3 weekly injections of HA. Our primary outcome was the mean change from baseline until 2 and 6 months post intervention in scores of visual analog scale, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC, and Lequesne index. We used analysis of variance for repeated-measures statistical test. Results: A total of 69 patients entered final analysis. The mean age of patients was 58.2 ± 7.41 years and 81.2% were women. In particular, total WOMAC index decreased from 42.9 ± 13.51 to 26.8 ± 13.45 and 24.4 ± 16.54 at 2 and 6 months in the newly developed PRGF group (within subjects P  = .001, and from 38.8 ± 12.62 to 27.8 ± 11.01 and 27.4 ± 11.38 at 2 and 6 months in the HA group (within subjects P  = .001, respectively (between subjects P  = .631. There was no significant difference between PRGF and HA groups in patients’ satisfaction and minor complications of injection, whereas patients in HA group reported significantly lower injection-induced pain. Conclusions: In 6 months follow up, our newly developed PRGF and HA, both are effective options to decrease pain and improvement of function in patients with symptomatic mild to moderate knee osteoarthritis.

  20. Numerical and analytical investigation towards performance enhancement of a newly developed rockfall protective cable-net structure

    Directory of Open Access Journals (Sweden)

    S. Dhakal

    2012-04-01

    Full Text Available In a previous companion paper, we presented a three-tier modelling of a particular type of rockfall protective cable-net structure (barrier, developed newly in Japan. Therein, we developed a three-dimensional, Finite Element based, nonlinear numerical model having been calibrated/back-calculated and verified with the element- and structure-level physical tests. Moreover, using a very simple, lumped-mass, single-degree-of-freedom, equivalently linear analytical model, a global-displacement-predictive correlation was devised by modifying the basic equation – obtained by combining the principles of conservation of linear momentum and energy – based on the back-analysis of the tests on the numerical model. In this paper, we use the developed models to explore the performance enhancement potential of the structure in terms of (a the control of global displacement – possibly the major performance criterion for the proposed structure owing to a narrow space available in the targeted site, and (b the increase in energy dissipation by the existing U-bolt-type Friction-brake Devices – which are identified to have performed weakly when integrated into the structure. A set of parametric investigations have revealed correlations to achieve the first objective in terms of the structure's mass, particularly by manipulating the wire-net's characteristics, and has additionally disclosed the effects of the impacting-block's parameters. Towards achieving the second objective, another set of parametric investigations have led to a proposal of a few innovative improvements in the constitutive behaviour (model of the studied brake device (dissipator, in addition to an important recommendation of careful handling of the device based on the identified potential flaw.