Opukushi horizontal well campaign: completion design and wellbore clean-up

Energy Technology Data Exchange (ETDEWEB)

Osode, P. I.; Dijkema, R. W. [Shell Petroleum Development Company of Nigeria (Nigeria)

1998-12-31

A three-well completion design and installation technique, and a horizontal well clean-up procedure employed as part of the on-going initiative to improve the Opukushi Oilfield in Nigeria was described. In an effort to improve the Field`s ultimate recovery and production potential, horizontal well technology was introduced during the second phase of field development which started in 1995. Openhole liner completion was the design of choice, dictated by the unconsolidated sandstone formation which characterizes the shallow horizons of the field. All three wells were completed in thin oil rim sands of about 70 ft, with 5-1/2 inch by 4-1/2 inch tapered slotted liner assemblies installed across 2300 to 3300 ft of 8-1/2 inch drainhole sections. Drilling was completed with low-solids drilling fluid; well clean-up was done with a coil-tubing unit using nitrified acid at underbalance condition. In addition to a description of the design and liner completion considerations, the paper also includes a comparison of performance data from the three wells with performance of conventional wells. A productivity improvement factor of 10 or better was reported for each of the wells. 6 refs., 2 tabs., 14 figs.

Aerodynamic design of horizontal axis wind turbine with innovative local linearization of chord and twist distributions

DEFF Research Database (Denmark)

Tahani, Mojtaba; Kavari, Ghazale; Masdari, Mehran

2017-01-01

This study is aimed to aerodynamically design a 1 mega-Watt horizontal axis wind turbine in order to obtain the maximum power coefficient by linearizing the chord and twist distributions. A new linearization method has been used for chord and twist distributions by crossing tangent line through...... the geometry of the blades determines the power generated by rotor, designing the blade is a very important issue. Herein, calculations are done for different types of airfoil families namely Risø-A1-21, Risø-A1-18, S809, S814 and Du 93-W-210. Hence, the effect of selecting different airfoil families is also...

A newly designed Y-shaped covered stent in the palliative treatment of hepatic hilar malignant obstruction: Case report

Energy Technology Data Exchange (ETDEWEB)

Kang, Byung Chul; Lee, So Won [Dept. of Radiology, Mokdong Hospital, Ewha Womans University College of Medicine, Seoul (Korea, Republic of); Chung, Hwan Hoon [Dept. of Radiology, Ansan Hospital, Korea University College of Medicine, Ansan (Korea, Republic of)

2013-01-15

We report a case in an inoperable patient with the hilar malignant biliary obstruction treated palliatively by the use of a newly designed Y-shaped covered stent without interfering contra-lateral bile duct. We percutaneously inserted a newly designed Y-shaped covered stent into a biliary tree in an inoperable patient with Bismuth Type II cholangiocarcinoma. We checked tubograms, enhanced CT studies, and blood bilirubin levels before, one week after, and at every three month after the stenting, by observing closely the signs of clinical infection as well. The follow-up period was about 12 months. The placement of the Y-shaped covered stent was successful and resulted in adequate biliary drainage in the immediate post-procedural tubogram and in the follow-up abdominal CT. The serum bilirubin levels did not show elevation after the insertion of the Y-shaped covered stent.

On Devising Boussinesq-type Equations with Bounded Eigenspectra: Two Horizontal Dimensions

DEFF Research Database (Denmark)

Eskilsson, Claes; Engsig-Karup, Allan Peter

2015-01-01

Boussinesq-type equations are used to describe the propagation and transformation of free-surface waves in the nearshore region. The nonlinear and dispersive performance of the equations are determined by tunable parameters. Recently the authors presented conditions on the free parameters under...... study and provide numerical experimentswhich confirms the theoretical results also is valid in two horizontal dimensions....

The dieting dilemma in patients with newly diagnosed type 2 diabetes: Does dietary restraint predict weight gain four years after diagnosis?

NARCIS (Netherlands)

Strien, T. van; Laar, F.A. van de; Leeuwe, J.F.J. van; Lucassen, P.L.B.J.; Hoogen, H.J.M. van den; Rutten, G.E.H.M.; Weel, C. van

2007-01-01

Objective: To examine whether dieting--restriction of food intake for the purpose of weight control--suppresses or promotes excessive food intake and weight gain. Design: A 4-year follow-up study of a dietary intervention in a sample of 97 patients with newly diagnosed Type 2 diabetes. Main Outcome

The dieting dilemma in patients with newly diagnosed type 2 diabetes: does dietary restraint predict weight gain 4 years after diagnosis?

NARCIS (Netherlands)

Strien, T. van; Laar, F.A. van de; Leeuwe, J.F.J. van; Lucassen, P.L.B.J.; Hoogen, H.J.M. van den; Rutten, G.E.H.M.; Weel, C. van

2007-01-01

OBJECTIVE: To examine whether dieting--restriction of food intake for the purpose of weight control--suppresses or promotes excessive food intake and weight gain. DESIGN: A 4-year follow-up study of a dietary intervention in a sample of 97 patients with newly diagnosed Type 2 diabetes. MAIN OUTCOME

Circulating zonulin levels in newly diagnosed Chinese type 2 diabetes patients.

Science.gov (United States)

Zhang, D; Zhang, L; Zheng, Y; Yue, F; Russell, R D; Zeng, Y

2014-11-01

Studies suggest that type 2 diabetes mellitus is associated with increased gut permeability. Human zonulin is the only physiological mediator discovered to date that is known to regulate gut permeability reversibly by disassembling intestinal tight junctions. However, the relationship between zonulin and type 2 diabetes remains to be defined, and no Chinese population-based data were reported. The aim of this study was to investigate the association between serum zonulin levels and type 2 diabetes in a Chinese Han population. 143 newly diagnosed type 2 diabetes patients, 124 patients with impaired glucose tolerance and 121 subjects with normal glucose tolerance were enrolled in this study. Serum zonulin was measured by ELISA. Patients with type 2 diabetes had higher serum zonulin levels than impaired or normal glucose tolerant subjects. Serum zonulin correlated with body mass index, waist-to-hip ratio, triglyceride, total cholesterol, HDL-C, fasting plasma glucose, 2h plasma glucose, HbA1c, tumor necrosis factor α, interleukin 6, HOMA-IR and QUICK index using correlation analysis (p zonulin levels were independently associated with insulin resistance (β = 0.024, p = 0.005). In logistic regression analysis, zonulin levels were an independent predictor of type 2 diabetes (OR = 1.080, p = 0.037). Serum zonulin levels are significantly elevated in newly diagnosed Chinese Type 2 diabetes patients, and are associated with dyslipidemia, inflammation and insulin resistance, indicating a potential role of zonulin in the pathophysiology of type 2 diabetes in Chinese. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Alterations found with computerized tomography in newly diagnosed type 2 diabetics

International Nuclear Information System (INIS)

Bruna, J.

1989-01-01

In 28 newly diagnosed type 2 diabetic patients (insulin-independent), computerized tomography (CT) was used to determine the density of the pancreas and the kidneys, densities of the liver, spleen and blood in the abdominal aorta, and to investigate pathological changes in the tissues mentioned above. The results were correlated with laboratory findings. The following changes were found: decreased density of the pancreas (29.4 H) and the liver (49.1 H) and increased density of the spleen (56.3 H) and blood in the abdominal aorta (43.7 H). The decreased density of the pancreas appears to be connected with disorders of lipoprotein metabolism. The decreased liver density was related to increased energy intake by food and to overweight evaluated by Broc's index. Other CT findings in the newly diagnosed type 2 diabetics (changes in the size of the pancreas, and kidneys, kidney cysts, nephrolithiasis, sclerotic plaques on aorta) were not significant. (author). 2 tabs., 11 refs

Horizontal Heat Exchanger Design and Analysis for Passive Heat Removal Systems

Energy Technology Data Exchange (ETDEWEB)

Vierow, Karen

2005-08-29

This report describes a three-year project to investigate the major factors of horizontal heat exchanger performance in passive containment heat removal from a light water reactor following a design basis accident LOCA (Loss of Coolant Accident). The heat exchanger studied in this work may be used in advanced and innovative reactors, in which passive heat removal systems are adopted to improve safety and reliability The application of horizontal tube-bundle condensers to passive containment heat removal is new. In order to show the feasibility of horizontal heat exchangers for passive containment cooling, the following aspects were investigated: 1. the condensation heat transfer characteristics when the incoming fluid contains noncondensable gases 2. the effectiveness of condensate draining in the horizontal orientation 3. the conditions that may lead to unstable condenser operation or highly degraded performance 4. multi-tube behavior with the associated secondary-side effects This project consisted of two experimental investigations and analytical model development for incorporation into industry safety codes such as TRAC and RELAP. A physical understanding of the flow and heat transfer phenomena was obtained and reflected in the analysis models. Two gradute students (one funded by the program) and seven undergraduate students obtained research experience as a part of this program.

Physiological evaluation of a newly designed lever mechanism for wheelchairs

NARCIS (Netherlands)

van der Woude, L H; Veeger, DirkJan (H. E. J.); de Boer, Y; Rozendal, R H

1993-01-01

Lever-propelled wheelchairs have been described as more efficient and less physically demanding than hand-rim-propelled wheelchairs. To evaluate a newly designed lever mechanism (MARC) in both one- and two-arm use, a series of wheelchair exercise tests were performed on a motor-driven treadmill.

Serum Lipids and Diabetic Retinopathy in Newly Diagnosed Type 2 Diabetic Subjects

Directory of Open Access Journals (Sweden)

Shahana Shermin

2011-07-01

Full Text Available Background: Diabetic retinopathy is the commonest and usually the first observable vascular complication of diabetes mellitus. Along with hyperglycaemia, dyslipidaemia is a contributing factor for the occurrence of diabetic retinopathy. It is postulated that dyslipidaemia results in formation of hard exudate by increasing blood viscosity and altering the fibrinolytic system. A case control study was carried out in the department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka during the period of January 2006 to December 2007 to evaluate the serum lipid profile in newly diagnosed type 2 diabetic subjects with diabetic retinopathy. Materials and Methods: Total 85 newly diagnosed type 2 diabetic subjects were included in this study, 40 were cases having retinopathy and 45 were age and sex matched controls without retinopathy. Serum triglyceride (TG, total cholesterol (TC, low density lipoprotein cholesterol (LDL-C and high density lipoprotein cholesterol (HDL-C were compared between cases and controls. Unpaired t-test and chi-square test were done between groups as tests of significance. Results: All the parameters of lipid profile showed dyslipidaemic trend both in cases and controls. In the cases TG was significantly higher and HDL-C was significantly lower than that of controls (p < 0.05 whereas no significant difference was found between cases and controls with respect to serum TC and LDL-C. Conclusion: It can be concluded that high TG and low HDL-C are associated with diabetic retinopathy in newly diagnosed type 2 diabetes.

Design of a machine to bore and line a long horizontal hole in tuff: Nevada Nuclear Waste Storage Investigations Project

International Nuclear Information System (INIS)

Friant, J.E.; Dowden, P.B.

1987-09-01

This report describes an engineering design for equipment capable of simultaneously drilling and lining deep horizontal bore holes. The ultimate use of the equipment is to bore up to 600 ft long, 3 ft diameter emplacement holes for a nuclear waste repository. The specific system designed is referred to as a Development Prototype Boring Machine (DPBM) which will be used to demonstrate the drilling/lining capability in field development tests. The system utilizes as in-hole electric drive and a vacuum chip removal and handling system. The drilling unit is capable of active directional control and uses laser-type alignment equipment. The system combines the features of a small steerable tunnel boring machine, combined with a horizontally-oriented raise drill, thereby utilizing current technology. All elements of the system are compact and mobile as required for a shaft entry, underground mining environment. 3 refs., 35 figs., 1 tab

Different Pathophysiological Phenotypes among Newly Diagnosed Type 2 Diabetes Patients

DEFF Research Database (Denmark)

Stidsen, Jacob

2013-01-01

Type 2 diabetes (T2D) can be considered a syndrome with several different pathophysiological mechanisms leading to hyperglycemia. Nonetheless, T2D is treated according to algorithms as if it was one disease entity. Methods: We investigated the prevalence of different pathophysiological phenotypes...... or secondary diabetes), classic obesity-associated insulin resistant diabetes ( f-P-C-peptide >= 568 pmol/l) and a normoinsulinopenic group (333 age of our new T2D patients was 61 years (range 21-95 years), 57% were men. We found that 3.0% newly diagnosed T2D patients...... suffered from LADA, 3.9% from secondary diabetes, 6.0% from steroid induced diabetes 5.9% had insulinopenic diabetes, whereas 56.7% presented the classic obesity-associated insulin-resistant phenotype. 24.6% was classified as normoinsulinopenic patients. Conclusion: We conclude that newly diagnosed T2D...

Design of wheel-type walking-assist device

International Nuclear Information System (INIS)

Jung, Seung Ho; Kim, Seung Ho; Kim, Chang Hoi; Seo, Yong Chil; Jung, Kyung Min; Lee, Sung Uk

2006-03-01

In this research, a outdoor wheel-type walking-assist device is developed to help an elder having a poor muscular strength at legs for walking, sitting and standing up easily at outdoors, and also for going and downing stairs. In conceptually designing, the environments of an elder's activity, the size of an elder's body and a necessary function of helping an elder are considered. This device has 4 wheels for stability. When an elder walks in incline plane with the proposed device, a rear-wing is rotated to keep the supporting device horizontal, regardless of an angle of inclination. A height-controlling device, which can control the height of the supporting device for adjusting an elder's height, is varied vertically to help an elder to sit and stand-up easily. Moreover, a outdoor wheel-type walking-assist device is conceptually designed and is made. In order to design it, the preview research is investigated firstly. On the basis of the proposed walking-assist device, the outdoor walking-assist device is designed and made. The outdoor wheel-type walking-assist device can go and down stairs automatically. This device go up and down the stair of having maximum 20cm height and an angle of 25 degrees with maximum 4 sec/stairs speed, and move at flatland with 60cm/sec speed

Thermal transient analysis applied to horizontal wells

Energy Technology Data Exchange (ETDEWEB)

Duong, A.N. [Society of Petroleum Engineers, Canadian Section, Calgary, AB (Canada)]|[ConocoPhillips Canada Resources Corp., Calgary, AB (Canada)

2008-10-15

Steam assisted gravity drainage (SAGD) is a thermal recovery process used to recover bitumen and heavy oil. This paper presented a newly developed model to estimate cooling time and formation thermal diffusivity by using a thermal transient analysis along the horizontal wellbore under a steam heating process. This radial conduction heating model provides information on the heat influx distribution along a horizontal wellbore or elongated steam chamber, and is therefore important for determining the effectiveness of the heating process in the start-up phase in SAGD. Net heat flux estimation in the target formation during start-up can be difficult to measure because of uncertainties regarding heat loss in the vertical section; steam quality along the horizontal segment; distribution of steam along the wellbore; operational conditions; and additional effects of convection heating. The newly presented model can be considered analogous to pressure transient analysis of a buildup after a constant pressure drawdown. The model is based on an assumption of an infinite-acting system. This paper also proposed a new concept of a heating ring to measure the heat storage in the heated bitumen at the time of testing. Field observations were used to demonstrate how the model can be used to save heat energy, conserve steam and enhance bitumen recovery. 18 refs., 14 figs., 2 appendices.

Ultraviolet spectra of field horizontal-branch A-type stars. II

International Nuclear Information System (INIS)

Philip, A.G.D.; Hayes, D.S.; Adelman, S.J.

1990-01-01

The spectra of six additional A-type stars have been obtained at low resolution between 1200 and 1900 A with the IUE. The energy distributions of four of the stars match that of the field horizontal branch (FHB) distribution in Huenemoerder et al. (1984) while those of the other two do not. Three of the FHB stars fall above a line in the C(19 - V)0 vs. (b-y)0 diagram; however, HD 60825 is anomalously blue for its C(19 - V) color. 7 refs

Knowledge and self-care practices regarding diabetes among newly diagnosed type 2 diabetics in Bangladesh: a cross-sectional study

Directory of Open Access Journals (Sweden)

Saleh Farzana

2012-12-01

Full Text Available Abstract Background Levels of knowledge about diabetes mellitus (DM among newly diagnosed diabetics in Bangladesh are unknown. This study assessed the relationship between knowledge and practices among newly diagnosed type 2 DM patients. Methods Newly diagnosed adults with type 2 diabetes (N = 508 were selected from 19 healthcare centers. Patients’ knowledge and self-care practices were assessed via interviewer-administered questionnaires using a cross-sectional design. Knowledge questions were divided into basic and technical sections. Knowledge scores were categorized as poor (mean + 1 SD. Chi square testing and multivariate logistic regression were conducted to examine the relationship between diabetes-related knowledge and self-care practices. Results Approximately 16%, 66%, and 18% of respondents had good, average, and poor (GAP basic knowledge respectively and 10%, 78%, and 12% of respondents had GAP technical knowledge, about DM. About 90% of respondents from both basic and technical GAP did not test their blood glucose regularly; a significant relationship existed between basic knowledge and glucose monitoring. Technical knowledge and foot care were significantly related, though 81% with good technical knowledge and about 70% from average and poor groups did not take care of their feet. Approximately 85%, 71%, and 52% of the GAP technical knowledge groups, consumed betel nuts; a significant relationship existed between technical knowledge and consumption of betel nuts. Around 88%, 92%, and 98% of GAP technical knowledge groups failed to follow dietary advice from a diabetes educator. About 26%, 42%, and 51% of GAP basic and technical sometimes ate meals at a fixed time (p Conclusions Newly diagnosed type 2 diabetics had similar levels of basic and technical knowledge of DM. Health education and motivation should create positive changes in diabetes-control-related self-care practices.

Reliability Based Geometric Design of Horizontal Circular Curves

Science.gov (United States)

Rajbongshi, Pabitra; Kalita, Kuldeep

2018-06-01

Geometric design of horizontal circular curve primarily involves with radius of the curve and stopping sight distance at the curve section. Minimum radius is decided based on lateral thrust exerted on the vehicles and the minimum stopping sight distance is provided to maintain the safety in longitudinal direction of vehicles. Available sight distance at site can be regulated by changing the radius and middle ordinate at the curve section. Both radius and sight distance depend on design speed. Speed of vehicles at any road section is a variable parameter and therefore, normally the 98th percentile speed is taken as the design speed. This work presents a probabilistic approach for evaluating stopping sight distance, considering the variability of all input parameters of sight distance. It is observed that the 98th percentile sight distance value is much lower than the sight distance corresponding to 98th percentile speed. The distribution of sight distance parameter is also studied and found to follow a lognormal distribution. Finally, the reliability based design charts are presented for both plain and hill regions, and considering the effect of lateral thrust.

Reliability Based Geometric Design of Horizontal Circular Curves

Science.gov (United States)

Rajbongshi, Pabitra; Kalita, Kuldeep

2018-03-01

Geometric design of horizontal circular curve primarily involves with radius of the curve and stopping sight distance at the curve section. Minimum radius is decided based on lateral thrust exerted on the vehicles and the minimum stopping sight distance is provided to maintain the safety in longitudinal direction of vehicles. Available sight distance at site can be regulated by changing the radius and middle ordinate at the curve section. Both radius and sight distance depend on design speed. Speed of vehicles at any road section is a variable parameter and therefore, normally the 98th percentile speed is taken as the design speed. This work presents a probabilistic approach for evaluating stopping sight distance, considering the variability of all input parameters of sight distance. It is observed that the 98th percentile sight distance value is much lower than the sight distance corresponding to 98th percentile speed. The distribution of sight distance parameter is also studied and found to follow a lognormal distribution. Finally, the reliability based design charts are presented for both plain and hill regions, and considering the effect of lateral thrust.

Increased gluconeogenesis in youth with newly diagnosed type 2 diabetes.

Science.gov (United States)

Chung, Stephanie T; Hsia, Daniel S; Chacko, Shaji K; Rodriguez, Luisa M; Haymond, Morey W

2015-03-01

The role of increased gluconeogenesis as an important contributor to fasting hyperglycaemia at diabetes onset is not known. We evaluated the contribution of gluconeogenesis and glycogenolysis to fasting hyperglycaemia in newly diagnosed youths with type 2 diabetes following an overnight fast. Basal rates (μmol kg(FFM) (-1) min(-1)) of gluconeogenesis ((2)H2O), glycogenolysis and glycerol production ([(2)H5] glycerol) were measured in 18 adolescents (nine treatment naive diabetic and nine normal-glucose-tolerant obese adolescents). Type 2 diabetes was associated with higher gluconeogenesis (9.2 ± 0.6 vs 7.0 ± 0.3 μmol kg(FFM) (-1) min(-1), p gluconeogenesis, glycogenolysis and glucose production were higher in diabetic youth (p ≤ 0.02). Glycerol concentration (84 ± 6 vs 57 ± 6 μmol/l, p = 0.01) and glycerol production (5.0 ± 0.3 vs 3.6 ± 0.5 μmol kg(FFM) (-1) min(-1), p = 0.03) were 40% higher in youth with diabetes. The increased glycerol production could account for only ~1/3 of substrate needed for the increased gluconeogenesis in diabetic youth. Increased gluconeogenesis was a major contributor to fasting hyperglycaemia and hepatic insulin resistance in newly diagnosed untreated adolescents and was an early pathological feature of type 2 diabetes. Increased glycerol availability may represent a significant source of new carbon substrates for increased gluconeogenesis but would not account for all the carbons required to sustain the increased rates.

Placement of a Newly Designed Y-Configured Bilateral Self-Expanding Metallic Stent for Hilar Biliary Obstruction: A Pilot Study.

Science.gov (United States)

Jiao, Dechao; Huang, Kai; Zhu, Ming; Wu, Gang; Ren, Jianzhuang; Wang, Yanli; Han, Xinwei

2017-01-01

Whether unilateral or bilateral drainage should be performed for malignant hilar biliary obstruction remains a matter of debate. Although a Y-stent with a central wide-open mesh facilitates bilateral stent placement, it has its own limitations. This study aims to evaluate the feasibility and efficacy of a newly designed Y-configured bilateral self-expanding metallic stent (SEMS) for the treatment of hilar biliary obstruction. In this retrospective study, 14 consecutive patients with unresectable malignant hilar biliary obstruction (Bismuth type II or higher), who underwent placement of a newly designed Y-configured bilateral SEMS for hilar biliary obstruction from April 2013 to March 2015, were included into this study. Data on technical success, clinical success, stent patency, complications and patient survival were collected. Technical and clinical success was 100 and 92.9 %, respectively. Mean serum bilirubin level was significantly decreased 1 month after stent placement (P hilar biliary obstruction using port docking deployment.

Design of horizontal test cryostat for testing two 650 MHz cavities: cryogenic considerations

Science.gov (United States)

Khare, P.; Gilankar, S.; Kush, P. K.; Lakshminarayanan, A.; Choubey, R.; Ghosh, R.; Jain, A.; Patel, H.; Gupta, P. D.; Hocker, A.; Ozelis, J. P.; Geynisman, M.; Reid, C.; Poloubotko, V.; Mitchell, D.; Peterson, T. J.; Nicol, T. H.

2017-02-01

Horizontal Test Cryostat has been designed for testing two 650 MHz "dressed" Superconducting Radio Frequency (SCRF) cavities in a single testing cycle at Raja Ramanna Centre for Advanced Technology, India (RRCAT) in collaboration with Fermi National Accelerator Laboratory, USA (FNAL). This cryostat will facilitate testing of two 5-cell 650 MHz SCRF cavities, in CW or pulsed regime, for upcoming High Intensity Superconducting Proton Accelerator projects at both countries. Two such HTS facilities are planned, one at RRCAT for Indian Spallation Neutron Source project (ISNS), which is on the horizon, and the other at FNAL, USA. A test cryostat, a part of horizontal test stand-2 (HTS-2) will be set up at RRCAT for Indian project. In order to maximize the utility of this facility, it can also be used to test two dressed 9-cell 1.3 GHz cavities and other similarly-sized devices. The facility assumes, as an input, the availability of liquid nitrogen at 80 K and liquid helium at 4.5 K and 2 K, with a refrigeration capacity of approximately 50 W at 2 K. Design work of cryostat has been completed and now procurement process is in progress. This paper discusses salient features of the cryostat. It also describes different design calculations and ANSYS analysis for cool down of few subsystems like cavity support system and liquid nitrogen cooled thermal radiation shield of horizontal test cryostat..

Time perspective and weight management behaviors in newly diagnosed Type 2 diabetes: a mediational analysis.

Science.gov (United States)

Hall, Peter A; Fong, Geoffrey T; Cheng, Alice Y

2012-12-01

The primary objective of the current study was to examine the extent to which domain-specific time perspective predicts weight management behaviors (dietary behavior and physical activity) among those newly diagnosed with Type 2 diabetes. A secondary objective was to test potential mediators of the hypothesized effect (behavioral intention, self-efficacy and control beliefs). A total of 204 adults newly diagnosed (≤6 months) with Type 2 diabetes participated in the study, which included a baseline assessment of domain-general and domain-specific time perspective, as well as strength of intention to perform two weight-management behaviors (dietary choice and physical activity); both weight-management behaviors were assessed again at 6 month follow-up. Hierarchical multiple regression analyses revealed a prospective association between domain-specific time perspective and uptake of weight management behaviors. Individuals with newly diagnosed T2DM possessing a future-oriented time perspective reported making less frequent fatty food choices and greater increases in physical activity over the 6-month follow-up interval. These effects were selectively mediated by intention strength, and not competing social cognitive variables. For both behaviors, the total effects and meditational models were robust to adjustments for demographics, body composition and disease variables. A future-oriented time perspective is prospectively associated with superior uptake of weight management behaviors among those with newly diagnosed Type 2 diabetes. The facilitating effect of future-oriented thinking appears to occur via enhanced strength of intentions to perform weight management behaviors.

Frequency of Ketoacidosis in Newly Diagnosed Type 1 Diabetic Children

Science.gov (United States)

Razavi, Zahra

2010-01-01

Objectives Diabetic ketoacidosis (DKA) is the leading cause of morbidity and mortality in children with type 1 diabetes mellitus (TIDM). Many patients with newly diagnosed type 1 diabetes present with DKA. The aim of this study is to determine the frequency and the clinical presentation of diabetic ketoacidosis at the diagnosis of type 1 diabetes mellitus in youths in hamadan, Western Province of Iran. Methods The Clinical and laboratory data of a total of 200 patients under 19 years of age with newly diagnosed type 1 diabetes mellitus between 1995-2005 were retrospectively reviewed. Statistical analysis was performed using SPSS 11. Results 48 (24%)of the children were presented in a state of ketoacidosis. Sever form of DKA (pH≤7.2) was observed in 54.5% of patients. The mean age at diagnosis was 7.3±5.15 years in DKA group and 8.59±3.07 in non-DKA group (p=0.22). 60.4% of patient with DKA were female whereas in the non-DKA group, 53.3% of patients were female, the difference was not significant (p=0.38). The duration of symptoms before diagnosis was 14.84±8.19 days in patients with DKA and 22.39±2.27 in the non-DKA group, (p=0.11). No significant difference was found between the age, sex and duration of the symptoms and occurance of DKA. Polydipsia (85.4) polyuria (83.3%), weakness (68.8%) and abdominal pain (52.1%) were the most frequently notified symptoms among the patients. In two cases, diagnosis of DKA was preceded by as appendicitis and the patient underwent appendectomy. Conclusion Frequency of DKA at onset of type 1 diabetes mellitus was significant in the studied region. However, it was lower than other regions in Asia. Polydipsia, polyuria, fatigue and abdominal pain were the most common symptoms on presentation. PMID:22125712

Frequency of Ketoacidosis in Newly Diagnosed Type 1 Diabetic Children

Directory of Open Access Journals (Sweden)

Zahra Razavi

2010-04-01

Full Text Available ABSTRACTObjectives: Diabetic ketoacidosis (DKA is the leading cause of morbidity and mortality in children with type 1 diabetes mellitus (TIDM. Many patients with newly diagnosed type 1 diabetes present with DKA. The aim of this study is to determine the frequency and the clinical presentation of diabetic ketoacidosis at the diagnosis of type 1 diabetes mellitus in youths in hamadan, Western Province of Iran.Methods: The Clinical and laboratory data of a total of 200 patients under 19 years of age with newly diagnosed type 1 diabetes mellitus between 1995-2005 were retrospectively reviewed. Statistical analysis was performed using SPSS 11.Results: 48 (24%of the children were presented in a state of ketoacidosis. Sever form of DKA (pH≤7.2 was observed in 54.5% of patients. The mean age at diagnosis was 7.3±5.15 years in DKA group and 8.59±3.07 in non-DKA group (p=0.22. 60.4% of patient with DKA were female whereas in the non-DKA group, 53.3% of patients were female, the difference was not significant (p=0.38. The duration of symptoms before diagnosis was 14.84±8.19 days in patients with DKA and 22.39±2.27 in the non-DKA group, (p=0.11. No significant difference was found between the age, sex and duration of the symptoms and occurance of DKA. Polydipsia (85.4 polyuria (83.3%, weakness (68.8% and abdominal pain (52.1% were the most frequently notified symptoms among the patients. In two cases, diagnosis of DKA was preceded by as appendicitis and the patient underwent appendectomy.Conclusion: Frequency of DKA at onset of type 1 diabetes mellitus was significant in the studied region. However, it was lower than other regions in Asia. Polydipsia, polyuria, fatigue and abdominal pain were the most common symptoms on presentation.

Estimation of monthly solar exposure on horizontal surface by Angstrom-type regression equation

International Nuclear Information System (INIS)

Ravanshid, S.H.

1981-01-01

To obtain solar flux intensity, solar radiation measuring instruments are the best. In the absence of instrumental data there are other meteorological measurements which are related to solar energy and also it is possible to use empirical relationships to estimate solar flux intensit. One of these empirical relationships to estimate monthly averages of total solar radiation on a horizontal surface is the modified angstrom-type regression equation which has been employed in this report in order to estimate the solar flux intensity on a horizontal surface for Tehran. By comparing the results of this equation with four years measured valued by Tehran's meteorological weather station the values of meteorological constants (a,b) in the equation were obtained for Tehran. (author)

Frequency of retinopathy in newly diagnosed patients of type 2 diabetes mellitus (dm)

International Nuclear Information System (INIS)

Khan, K.A.; Kamran, S.M.; Qureshi, M.N.

2015-01-01

This study was to determine the frequency of retinopathy in newly diagnosed type-II Diabetics. Study Design: Cross sectional descriptive study. Place and Duration of Study: It was conducted at Department of medicine, Military Hospital (MH), Rawalpindi from 1st Jan 2012 to 30 Jun 2012. Material and Methods: We included 200 patients of type-II DM from both genders diagnosed in last 03 months from both outdoor and indoor departments in the age range of 40 to 70 years by consecutive sampling. All patients having co morbidities affecting retina were excluded. Informed written consent was taken before enrollment. Formal approval of the study was taken from hospital ethical committee. Ocular Fundoscopy was performed with WelchAllyn Ophthalmoscope (REF 11470) as per standard protocols and both eyes were examined. The grade of DR (diabetic retinopathy) awarded as per highest changes in any of the two eyes. All tests were carried by a single person to avoid inter-observer variations. Findings of ocular fundoscopy were confirmed by ophthalmologist. All data was analyzed by using SPSS version 11. Results: Out of 200 subjects 63.5% were male and 36.5% were female. Age ranged from 40 to 70 years with mean age of 51.05+ 6.910 years. 29 (14.5%) subjects had Diabetic retinopathy. Out of 29 patients, 24 (82.8%) had preproliferative and 5 (17.2%) had proliferative diabetic retinopathy. Conclusion: A significant proportion of diabetic patients have retinopathy at the time of diagnosis of their disease which is more common in males and with increasing age. It is recommended to thoroughly screen the newly diagnosed diabetics for early detection of diabetic retinopathy and its management involving early referral to eye specialist. (author)

Horizontal well impact on heavy oil supply

International Nuclear Information System (INIS)

Bowers, B.; Bielecki, J.; Hu, J.; Wall, B.; Drummond, K.

1993-01-01

Horizontal wells can take advantage of gravity drainage mechanisms, which can be important in conventional heavy oil and bitumen recovery. Horizontal drilling will impact on the development of established conventional heavy oil pools by infill drilling and application of enhanced recovery techniques. There will also be an impact on the development of extensions to established and newly discovered heavy oil pools, as well as a major impact on development of bitumen resources. To assess the impact of horizontal drilling on heavy oil supply, high-impact and low-impact scenarios were evaluated under specified oil-price assumptions for four heavy oil areas in Saskatchewan and Alberta. Horizontal well potential for infill drilling, waterflood projects, and thermal projects was assessed and estimates were made of such developments as reserves additions and heavy oil development wells under the two scenarios. In the low case, projected supply of conventional heavy oil and bitumen stabilizes at a level in the 90,000-94,000 m 3 /d after 1994. In the high case, overall supply continuously grows from 80,000 m 3 /d in 1992 to 140,000 m 3 /d in 2002. Through application of horizontal drilling, reserves additions in western Canada could be improved by ca 100 million m 3 by 2002. 14 figs., 6 tabs

Hydrodynamic and mechanical tests of a newly improved counter-current multi-stage centrifugal extractor

International Nuclear Information System (INIS)

Ionita, Gheorghe; Mirica, Dumitru; Croitoru, Cornelia; Stefanescu, Ioan; Retegan, Teodora

2003-01-01

Total actinide recovery, lanthanide/actinide separation and the selective partitioning of actinide from high level waste (HLW) are nowadays of major interest. Actinide partitioning with a view to safe disposing of HLW or utilization in many other applications of recovered elements involves an extraction process usually carried out by means of a mixer-settler, pulse column or centrifugal contactor. This last, presents some doubtless advantages and responds to the above mentioned goals. A new type of counter-current multistage centrifugal extractor has been designed and built. Similar apparatus was not found in the literature published to-date. The counter-current multi-stage centrifugal extractor is a stainless steel cylinder with an effective length of 346 mm, the effective diameter of 100 mm and a volume of 1.5 liters, working in horizontal position. The new internal structure and geometry of the new advanced centrifugal extractor consisting of nine cells (units), five rotation units, two mixing units, two propelling units and two final plates, ensures the counter-current running of the two phases.The central shaft having the rotation cells fixed on it is coupled by an intermediary connection to a electric motor of high rotation speed. Conceptual layout of the advanced counter-current multi-stage centrifugal extractor is presented. The newly designed extractor has been tested at 1000-3000 rot/min for a ratio of the aqueous/organic phase =1 to examine the mechanical behavior and the hydrodynamics of the two phases in countercurrent. The results showed that the performances have been generally good and the design requirements were fulfilled. The newly designed counter-current multistage centrifugal extractor appears to be a promising way to increase extraction rate of radionuclides and metals from liquid effluents. (authors)

Comparison of a newly developed binary typing with ribotyping and multilocus sequence typing methods for Clostridium difficile.

Science.gov (United States)

Li, Zhirong; Liu, Xiaolei; Zhao, Jianhong; Xu, Kaiyue; Tian, Tiantian; Yang, Jing; Qiang, Cuixin; Shi, Dongyan; Wei, Honglian; Sun, Suju; Cui, Qingqing; Li, Ruxin; Niu, Yanan; Huang, Bixing

2018-04-01

Clostridium difficile is the causative pathogen for antibiotic-related nosocomial diarrhea. For epidemiological study and identification of virulent clones, a new binary typing method was developed for C. difficile in this study. The usefulness of this newly developed optimized 10-loci binary typing method was compared with two widely used methods ribotyping and multilocus sequence typing (MLST) in 189 C. difficile samples. The binary typing, ribotyping and MLST typed the samples into 53 binary types (BTs), 26 ribotypes (RTs), and 33 MLST sequence types (STs), respectively. The typing ability of the binary method was better than that of either ribotyping or MLST expressed in Simpson Index (SI) at 0.937, 0.892 and 0.859, respectively. The ease of testing, portability and cost-effectiveness of the new binary typing would make it a useful typing alternative for outbreak investigations within healthcare facilities and epidemiological research. Copyright © 2018 Elsevier B.V. All rights reserved.

Effects of newly designed hospital buildings on staff perceptions : a pre-post study to validate design decisions

NARCIS (Netherlands)

Schreuder, E.J.A.; Heel, L. van; Goedhart, R.; Dusseldorp, E.; Schraagen, J.M.C.; Burdorf, A.

2015-01-01

Objective: This study investigates effects of the newly built nonpatient-related buildings of a large university medical center on staff perceptions and whether the design objectives were achieved. Background: The medical center is gradually renewing its hospital building area of 200,000 m.(2) This

Non-Uniform Dose Mapping Controlled by Modulated Vertical and Horizontal Scans

International Nuclear Information System (INIS)

Ninomiya, S.; Kimura, Y.; Kudo, T.; Ochi, A.; Toda, R.; Tsukihara, M.; Sato, F.; Fuse, G.; Ueno, K.; Sugitani, M.

2008-01-01

Since geometries of semi-conductor devices continue to shrink, the requirement for each process becomes severer to keep uniformity of electrical parameters of the semi-conductor devices. A larger wafer also causes larger variations. Thus it has been strongly required for ion implantation process to compensate for the variations from other processes because of its good dose controllability. A newly developed mapping of intentional non-uniform dosage system, which is named 'MIND system', is implemented in SEN's single-wafer-type implanters. The MIND system controls both horizontal and vertical scan speed simultaneously. Intentional two-dimensional non-uniform profiles of sheet resistance, such as concentric and eccentric profiles, are obtained only by single-step ion implantation.

Lack of effect of intermittently administered sodium fusidate in patients with newly diagnosed type 1 diabetes mellitus: the FUSIDM trial

DEFF Research Database (Denmark)

Conget, I; Aguilera, E; Pellitero, S

2005-01-01

We evaluated in a double-blind study the effect of early treatment with the immunomodulatory drug fusidin in patients with newly diagnosed type 1 diabetes mellitus.......We evaluated in a double-blind study the effect of early treatment with the immunomodulatory drug fusidin in patients with newly diagnosed type 1 diabetes mellitus....

In vitro evaluation of force-expansion characteristics in a newly designed orthodontic expansion screw compared to conventional screws

Directory of Open Access Journals (Sweden)

Oshagh Morteza

2009-01-01

Full Text Available Objective : Expansion screws like Hyrax, Haas and other types, produce heavy interrupted forces which are unfavorable for dental movement and could be harmful to the tooth and periodontium. The other disadvantage of these screws is the need for patient cooperation for their regular activation. The purpose of this study was to design a screw and compare its force- expansion curve with other types. Materials and Methods : A new screw was designed and fabricated in the same dimension, with conventional types, with the ability of 8 mm expansion (Free wire length: 12 mm, initial compression: 4.5 mm, spring wire diameter: 0.4 mm, spring diameter: 3 mm, number of the coils: n0 ine, material: s0 tainless steel. In this in vitro study, the new screw was placed in an acrylic orthodontic appliance, and after mounting on a stone cast, the force-expansion curve was evaluated by a compression test machine and compared to other screws. Results : Force-expansion curve of designed screw had a flatter inclination compared to other screws. Generally it produced a light continuous force (two to 3.5 pounds for every 4 mm of expansion. Conclusion : In comparison with heavy and interrupted forces of other screws, the newly designed screw created light and continuous forces.

Changes of β-cell function after short-term transient intensive insulin treatment in newly diagnosed type 2 diabetes patients

International Nuclear Information System (INIS)

Tian Xiaoping; Zhuang Huiqin; Su Cainu; Xu Ning; Yin Dong; Hui Yuan; Wu Yan

2007-01-01

To evaluate the effect of short-term intensive insulin treatment on β-cell function in newly diagnosed type 2 diabetes patients with apparently hyperglycemia, twenty-four newly diagnosed type 2 diabetes patients with FPG more than 12.0 mmol/L were treated by short-term transient intensive insulin in average 9.04-4.8 days. Their β-cell function was assessed by oral glucose tolerance test. The FPG, HbAlc and HOMA IR of patients were significantly decreased (P<0.01), while the insulin, the Area Under Curve (AUC) of insulin and HOMA β were significantly increased (P<0.01) after the treatment with insulin. Improvement of β-cell function can be induced by short-term intensive insulin treatment for newly diagnosed type 2 diabetes patients with apparently hyperglycemia. (authors)

Objective measurements of activity patterns in people with newly diagnosed Type 2 diabetes demonstrate a sedentary lifestyle.

Science.gov (United States)

Cichosz, S L; Fleischer, J; Hoeyem, P; Laugesen, E; Poulsen, P L; Christiansen, J S; Ejskjær, N; Hansen, T K

2013-09-01

To evaluate physical activity in people with newly diagnosed Type 2 diabetes using objective measures. We analysed data from a study aimed at assessing carotid femoral pulse wave velocity in which a piezoelectric accelerometer was worn by 100 people with newly diagnosed Type 2 diabetes and by 100 age- and sex-matched control subjects. Differences in physical activity patterns were investigated. Compared with the control group, the people with Type 2 diabetes spent significantly more time engaged in sedentary or lower level activities during the day, with a mean (sd) time of 926 (44) vs 898 (70) min, P sedentary lifestyle compared with well-matched controls. © 2013 The Authors. Diabetic Medicine © 2013 Diabetes UK.

The Interplay of Different Types of Governance in Horizontal Cooperations

DEFF Research Database (Denmark)

Raue, Jan Simon; Wieland, Andreas

2015-01-01

Purpose – Over the last decades, horizontal cooperations between logistics service providers (LSPs) have become a well-established organizational form and their use is expected to grow even further in the future. In spite of this increasing importance of horizontal LSP cooperations, little research...

Numerical modelling of cuttings transport in horizontal wells using conventional drilling fluids

Energy Technology Data Exchange (ETDEWEB)

Li, Y.; Bjorndalen, E.; Kuru, E. [Alberta Univ., Edmonton, AB (Canada)

2004-07-01

Some of the problems associated with poor wellbore cleaning include high drag or torque, slower rate of penetration, formation fractures and difficulty in wellbore steering. Some of the factors that affect cuttings transport include drilling fluid velocity, inclination angle, drilling fluid viscosity and drilling rate. The general practice is to stop drilling when necessary to clean boreholes with viscous pills, pipe rotation or drilling fluid circulation. It is important to predict when drilling should be stopped for remedial wellbore cleaning. This can be accomplished with a transient cuttings transport model which can improve drilling hydraulics, particularly in long horizontal well sections and extended reach (ERD) wells. This paper presents a newly developed 1-dimensional transient mechanistic model of cuttings transport with conventional (incompressible) drilling fluids in horizontal wells. The numerically solved model predicts the height of cutting beds as a function of different drilling operational parameters such as fluid flow rate and rheological characteristics, drilling rates, wellbore geometry and drillpipe eccentricity. Sensitivity analysis has demonstrated the effects of these parameters on the efficiency of solids transport. The proposed model can be used in the creation of computer programs designed to optimize drilling fluid rheology and flow rates for horizontal well drilling. 29 refs., 3 tabs., 12 figs.

Design of a Horizontal Penetrometer for Measuring On‑the‑Go Soil Resistance

Directory of Open Access Journals (Sweden)

Davut Karayel

2010-10-01

Full Text Available Soil compaction is one of the main negative factors that limits plant growth and crop yield. Therefore, it is important to determine the soil resistance level and map it for the field to find solutions for the negative effects of the compaction. Nowadays, high powered communication technology and computers help us on this issue within the approach of precision agriculture applications. This study is focused on the design of a penetrometer, which can make instantaneous soil resistance measurements in the soil horizontally and data acquisition software based on the GPS (Global Positioning System. The penetrometer was designed using commercial 3D parametric solid modelling design software. The data acquisition software was developed in Microsoft Visual Basic.NET programming language. After the design of the system, manufacturing and assembly of the system was completed and then a field experiment was carried out. According to the data from GPS and penetration resistance values which are collected in Microsoft SQL Server database, a Kriging method by ArcGIS was used and soil resistance was mapped in the field for a soil depth of 40 cm. During operation, no faults, either in mechanical and software parts, were seen. As a result, soil resistance values of 0.2 MPa and 3 MPa were obtained as minimum and maximum values, respectively. In conclusion, the experimental results showed that the designed system works quite well in the field and the horizontal penetrometer is a practical tool for providing on‑line soil resistance measurements. This study contributes to further research for the development of on-line soil resistance measurements and mapping within the precision agriculture applications.

Design of a horizontal penetrometer for measuring on-the-go soil resistance.

Science.gov (United States)

Topakci, Mehmet; Unal, Ilker; Canakci, Murad; Celik, Huseyin Kursat; Karayel, Davut

2010-01-01

Soil compaction is one of the main negative factors that limits plant growth and crop yield. Therefore, it is important to determine the soil resistance level and map it for the field to find solutions for the negative effects of the compaction. Nowadays, high powered communication technology and computers help us on this issue within the approach of precision agriculture applications. This study is focused on the design of a penetrometer, which can make instantaneous soil resistance measurements in the soil horizontally and data acquisition software based on the GPS (Global Positioning System). The penetrometer was designed using commercial 3D parametric solid modelling design software. The data acquisition software was developed in Microsoft Visual Basic.NET programming language. After the design of the system, manufacturing and assembly of the system was completed and then a field experiment was carried out. According to the data from GPS and penetration resistance values which are collected in Microsoft SQL Server database, a Kriging method by ArcGIS was used and soil resistance was mapped in the field for a soil depth of 40 cm. During operation, no faults, either in mechanical and software parts, were seen. As a result, soil resistance values of 0.2 MPa and 3 MPa were obtained as minimum and maximum values, respectively. In conclusion, the experimental results showed that the designed system works quite well in the field and the horizontal penetrometer is a practical tool for providing on-line soil resistance measurements. This study contributes to further research for the development of on-line soil resistance measurements and mapping within the precision agriculture applications.

A test section design to simulate horizontal two-phase air-water flow

International Nuclear Information System (INIS)

Faccini, Jose Luiz H.; Cesar, Silvia B.G.; Coutinho, Jorge A.; Freitas, Sergio Carlos; Addor, Pedro N.

2002-01-01

In this work an air-water two-phase flow horizontal test section assembling at Nuclear Engineering Institute (IEN) is presented. The test section was designed to allow four-phase flow patterns to be simulated: bubble flow, stratified flow, wave flow and slug flow. These flow patterns will be identified by non-conventional ultrasonic techniques which have been developed to meet this particular application. Based on the separated flow and drift-flux models the test section design steps are shown. A description of the test section and its instrumentation and data acquisition system is also provided. (author)

Nephrotoxicity of cyclosporin A in patients with newly diagnosed type 1 diabetes mellitus

DEFF Research Database (Denmark)

Feldt-Rasmussen, B; Jensen, T; Dieperink, H

1990-01-01

Renal function was studied in 18 patients with Type 1 diabetes mellitus. All were participating in the Canadian-European randomized placebo-controlled cyclosporin trial in newly diagnosed Type 1 diabetic patients, nine being randomized to placebo, and nine to cyclosporin A. During treatment for 12...... corrected for differences in blood glucose control it appeared that in three out of nine patients glomerular filtration rate had not completely returned to the reference range of the placebo group. We conclude that the nephrotoxic side-effects of cyclosporin A treatment for 1 year are reversible. There are...

Small horizontal emittance in the TESLA damping ring

International Nuclear Information System (INIS)

Decking, W.

2001-01-01

The present TESLA damping ring is designed for a normalized horizontal emittance of 8x10 -6 m. γ-γ collisions at the TESLA linear collider will benefit from a further decrease of the horizontal emittance. This paper reviews the processes which limit the horizontal emittance in the damping ring. Preliminary estimates on the smallest horizontal emittance for the present TESLA damping ring design as well as an ultimate limit of the emittance reachable with the TESLA damping ring concept will be given

Korean Red Ginseng Improves Glucose Control in Subjects with Impaired Fasting Glucose, Impaired Glucose Tolerance, or Newly Diagnosed Type 2 Diabetes Mellitus

OpenAIRE

Bang, Hyangju; Kwak, Jung Hyun; Ahn, Hyeon Yeong; Shin, Dong Yeob; Lee, Jong Ho

2014-01-01

This study was designed to evaluate the effect of Korean red ginseng (KRG) supplementation on glucose control in subjects with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or newly diagnosed type 2 diabetes mellitus (T2DM). The study was a 12-week randomized, double-blinded, placebo-controlled (5 g of KRG [n=21] or placebo [n=20] in tablet form) trial. Glucose-related biomarkers, including serum and whole blood levels of glucose, insulin, and C-peptide, were measured by 2...

Incretin secretion in obese Korean children and adolescents with newly diagnosed type 2 diabetes.

Science.gov (United States)

Park, So Hyun; Jung, Min Ho; Cho, Won Kyoung; Park, Mi Sun; Suh, Byung Kyu

2016-01-01

The role of incretins in type 2 diabetes is controversial. This study investigated the association between incretin levels in obese Korean children and adolescents newly diagnosed with type 2 diabetes. We performed a 2-hr oral glucose tolerance test (OGTT) in obese children and adolescents with type 2 diabetes and with normal glucose tolerance. Twelve obese children and adolescents with newly diagnosed type 2 diabetes (DM group) and 12 obese age-matched subjects without type 2 diabetes (NDM group) were included. An OGTT was conducted and insulin, C-peptide, glucagon, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) were measured during the OGTT. The mean age of the patients was 13·8 ± 2·0 years, and the mean body mass index (BMI) Z-score was 2·1 ± 0·5. The groups were comparable in age, sex, BMI Z-score and waist:hip ratio. The DM group had significantly lower homeostasis model assessment of β and insulinogenic index values (P 1). The homeostasis model assessment of insulin resistance index was not different between the two groups. Insulin and C-peptide secretions were significantly lower in the DM group than in the NDM group (P 1). Total GLP-1 secretion was significantly higher in the DM group while intact GLP-1 and GIP secretion values were not significantly different between the two groups. Impaired insulin secretion might be important in the pathogenesis of type 2 diabetes in obese Korean children and adolescents, however, which may not be attributed to incretin secretion. © 2015 John Wiley & Sons Ltd.

Site characterization plan conceptual design report for a high-level nuclear waste repository in salt, horizontal emplacment mode: Volume 1

International Nuclear Information System (INIS)

1987-12-01

This Conceptual Design Report describes the conceptual design of a high-level nuclear waste repository in salt at a proposed site in Deaf Smith County, Texas. Waste receipt, processing, packaging, and other surface facility operations are described. Operations in the shafts and underground are described, including waste hoisting, transfer, and horizontal emplacement. This report specifically addresses the horizontal emplacement mode, the passive alternate design for the repository. Waste retrieval capability is described. The report includes a description of the layout of the surface, shafts, and underground. Major equipment items are identified. The report includes plans for decommissioning and sealing of the facility. The report discusses how the repository will satisfy performance objectives. Chapters are included on basis for design, design analyses, and data requirements for completion of future design efforts. 105 figs., 52 tabs

Kinetic Analysis of Horizontal Plyometric Exercise Intensity.

Science.gov (United States)

Kossow, Andrew J; Ebben, William P

2018-05-01

Kossow, AJ, DeChiara, TG, Neahous, SM, and Ebben, WP. Kinetic analysis of horizontal plyometric exercise intensity. J Strength Cond Res 32(5): 1222-1229, 2018-Plyometric exercises are frequently performed as part of a strength and conditioning program. Most studies assessed the kinetics of plyometric exercises primarily performed in the vertical plane. The purpose of this study was to evaluate the multiplanar kinetic characteristics of a variety of plyometric exercises, which have a significant horizontal component. This study also sought to assess sex differences in the intensity progression of these exercises. Ten men and 10 women served as subjects. The subjects performed a variety of plyometric exercises including the double-leg hop, standing long jump, single-leg standing long jump, bounding, skipping, power skipping, cone hops, and 45.72-cm hurdle hops. Subjects also performed the countermovement jump for comparison. All plyometric exercises were evaluated using a force platform. Dependent variables included the landing rate of force development and landing ground reaction forces for each exercise in the vertical, frontal, and sagittal planes. A 2-way mixed analysis of variance with repeated-measures for plyometric exercise type demonstrated main effects for exercise type for all dependent variables (p ≤ 0.001). There was no significant interaction between plyometric exercise type and sex for any of the variable assessed. Bonferroni-adjusted pairwise comparisons identified a number of differences between the plyometric exercises for the dependent variables assessed (p ≤ 0.05). These findings should be used to guide practitioners in the progression of plyometric exercise intensity, and thus program design, for those who require significant horizontal power in their sport.

The use of a newly designed nonabsorbable polymeric stent in reconstructing the vas deferens: a feasibility study in New Zealand white rabbits

NARCIS (Netherlands)

Vrijhof, Eric J.; de Bruine, Adriaan; Zwinderman, Aeilko H.; Lycklama à Nijeholt, August A. B.; Koole, Leo H.

2005-01-01

OBJECTIVES: To investigate the use of a newly designed stent in the reconstruction of the vas deferens. MATERIALS AND METHODS: In 26 New Zealand White rabbits, 13 conventional one-layer microscopic reconstructions were compared with 13 stented reconstructions of the vas deferens. The newly designed

Postclosure performance assessment of the SCP [Site Characterization Plan] conceptual design for horizontal emplacement: Revision 1

International Nuclear Information System (INIS)

1987-08-01

This report is a preliminary postclosure performance assessment of the repository design specified in the Site Characterization Plan Conceptual Design Report (SCP-CDR) for horizontal emplacement of high-level nuclear waste. At the time that these analyses were done, horizontal emplacement was the preferred orientation for the waste packages but vertical emplacement is now the reference design. This assessment consists of (1) a review of the regulatory requirements and strategy to demonstrate compliance with these requirements, (2) an analysis of the performance of the total repository system, (3) an analysis of the thermomechanical behavior of the repository, (4) an analysis of brine mobility in the repository, (5) an analysis of the waste package performance, (6) an analysis of the performance of seals, and (7) comments on the sensitivity of the various performance measures to uncertainties in the data and models. These are preliminary analyses and, in most cases, involve bounding calculations of the repository behavior. They have several purposes including (1) assessing how well this conceptual design ''measures up'' against requirements, (2) gaining experience in implementing the performance assessment strategy and tools and thereby learning where improvements are needed, (3) helping to identify needed data, and (4) helping to indicate required design modifications. 26 refs., 40 figs., 20 tabs

A newly designed attachment device of multipurpose frame for neuronavigator. Technical note.

Science.gov (United States)

Singh, A K; Okudera, H; Kobayashi, S; Osawa, M; Tokushige, K

1994-01-01

A newly designed attachment device of the multipurpose head frame (Sugita) for Neuronavigator (Watanabe) is presented with an illustrative case of glioblastoma in an eloquent area. This has extended the usefulness of the neuronavigator for those who prefer and use the multipurpose head frame, while the requirements for keeping a stereotactic combination and the original concept of the multipurpose head frame, as well as that of the neuronavigator have been kept undisturbed.

The Process of Horizontal Differentiation: Two Models.

Science.gov (United States)

Daft, Richard L.; Bradshaw, Patricia J.

1980-01-01

Explores the process of horizontal differentiation by examining events leading to the establishment of 30 new departments in five universities. Two types of horizontal differentiation processes--administrative and academic--were observed and each was associated with different organizational conditions. (Author/IRT)

Diabetes education improves depressive state in newly diagnosed patients with type 2 diabetes

OpenAIRE

Chen, Bin; Zhang, Xiyao; Xu, Xiuping; Lv, Xiaofeng; Yao, Lu; Huang, Xu; Guo, Xueying; Liu, Baozhu; Li, Qiang; Cui, Can

2013-01-01

Objectives: The prevalence of depression is relatively high in individuals with diabetes. However, screening and monitoring of depressive state in patients with diabetes is still neglected in developing countries and the treatment of diabetes-related depression is rarely performed in these countries. In this study, our aim was to study the role of diabetes education in the improvement of depressive state in newly diagnosed patients with type 2 diabetes. Methods: The Dutch version of the cente...

Vertical and horizontal subsidiarity

Directory of Open Access Journals (Sweden)

Ivan V. Daniluk

2016-02-01

Full Text Available This article makes an attempt to analyze the principle of subsidiarity in its two main manifestations, namely vertical and horizontal, to outline the principles of relations between the state and regions within the vertical subsidiarity, and features a collaboration of the government and civil society within the horizontal subsidiarity. Scientists identify two types, or two levels of the subsidiarity principle: vertical subsidiarity and horizontal subsidiarity. First, vertical subsidiarity (or territorial concerning relations between the state and other levels of subnational government, such as regions and local authorities; second, horizontal subsidiarity (or functional concerns the relationship between state and citizen (and civil society. Vertical subsidiarity expressed in the context of the distribution of administrative responsibilities to the appropriate higher level lower levels relative to the state structure, ie giving more powers to local government. However, state intervention has subsidiary-lower action against local authorities in cases of insolvency last cope on their own, ie higher organisms intervene only if the duties are less authority is insufficient to achieve the goals. Horizontal subsidiarity is within the relationship between power and freedom, and is based on the assumption that the concern for the common good and the needs of common interest community, able to solve community members (as individuals and citizens’ associations and role of government, in accordance horizontal subsidiarity comes to attracting features subsidiarity assistance, programming, coordination and possibly control.

Factors associated with initiation of antihyperglycaemic medication in UK patients with newly diagnosed type 2 diabetes

Directory of Open Access Journals (Sweden)

Sinclair Alan J

2012-03-01

Full Text Available Abstract Aim To assess the factors associated with antihyperglycaemic medication initiation in UK patients with newly diagnosed type 2 diabetes. Methods In a retrospective cohort study, patients with newly diagnosed type 2 diabetes were identified during the index period of 2003-2005. Eligible patients were ≥ 30 years old at the date of the first observed diabetes diagnosis (referred to as index date and had at least 2 years of follow-up medical history (N = 9,158. Initiation of antihyperglycaemic medication (i.e., treatment was assessed in the 2-year period following the index date. Adjusted Cox regression models were used to examine the association between time to medication initiation and patient age and other factors. Results Mean (SD HbA1c at diagnosis was 8.1% (2.3. Overall, 51% of patients initiated antihyperglycaemic medication within 2 years (65%, 55%, 46% and 40% for patients in the 30- th, 75th percentile time to treatment initiation was 63 (8, 257 days. Of the patients with HbA1c ≥ 7.5% at diagnosis, 87% initiated treatment within 2 years. These patients with a higher HbA1c also had shorter time to treatment initiation (adjusted hazard ratio (HR = 2.44 [95% confidence interval (CI: 1.61, 3.70]; p Conclusions In this UK cohort of patients with newly diagnosed type 2 diabetes, only 51% had antihyperglycaemic medication initiated over a 2-year period following diagnosis. Older patients were significantly less likely to have been prescribed antihyperglycaemic medications. Elevated HbA1c was the strongest factor associated with initiating antihyperglycaemic medication in these patients.

Horizontal and Vertical Rule Bases Method in Fuzzy Controllers

OpenAIRE

Aminifar, Sadegh; bin Marzuki, Arjuna

2013-01-01

Concept of horizontal and vertical rule bases is introduced. Using this method enables the designers to look for main behaviors of system and describes them with greater approximations. The rules which describe the system in first stage are called horizontal rule base. In the second stage, the designer modulates the obtained surface by describing needed changes on first surface for handling real behaviors of system. The rules used in the second stage are called vertical rule base. Horizontal...

Horizontal alveolar bone loss: A periodontal orphan

Science.gov (United States)

Jayakumar, A.; Rohini, S.; Naveen, A.; Haritha, A.; Reddy, Krishnanjeneya

2010-01-01

Background: Attempts to successfully regenerate lost alveolar bone have always been a clinician’s dream. Angular defects, at least, have a fairer chance, but the same cannot be said about horizontal bone loss. The purpose of the present study was to evaluate the prevalence of horizontal alveolar bone loss and vertical bone defects in periodontal patients; and later, to correlate it with the treatment modalities available in the literature for horizontal and vertical bone defects. Materials and Methods: The study was conducted in two parts. Part I was the radiographic evaluation of 150 orthopantomographs (OPGs) (of patients diagnosed with chronic periodontitis and seeking periodontal care), which were digitized and read using the AutoCAD 2006 software. All the periodontitis-affected teeth were categorized as teeth with vertical defects (if the defect angle was ≤45° and defect depth was ≥3 mm) or as having horizontal bone loss. Part II of the study comprised search of the literature on treatment modalities for horizontal and vertical bone loss in four selected periodontal journals. Results: Out of the 150 OPGs studied, 54 (36%) OPGs showed one or more vertical defects. Totally, 3,371 teeth were studied, out of which horizontal bone loss was found in 3,107 (92.2%) teeth, and vertical defects were found only in 264 (7.8%) of the teeth, which was statistically significant (P<.001). Search of the selected journals revealed 477 papers have addressed the treatment modalities for vertical and horizontal types of bone loss specifically. Out of the 477 papers, 461 (96.3%) have addressed vertical bone loss, and 18 (3.7%) have addressed treatment options for horizontal bone loss. Two papers have addressed both types of bone loss and are included in both categories. Conclusion: Horizontal bone loss is more prevalent than vertical bone loss but has been sidelined by researchers as very few papers have been published on the subject of regenerative treatment modalities for

Analysis of Inflammatory Mediators in Prediabetes and Newly Diagnosed Type 2 Diabetes Patients

OpenAIRE

Wang, Zhen; Shen, Xu-Hui; Feng, Wen-Ming; Ye, Guo-fen; Qiu, Wei; Li, Bo

2016-01-01

This study evaluated the inflammatory markers in prediabetes and newly diagnosed type 2 diabetes mellitus (T2DM). Inflammatory markers levels were analyzed using one-way analysis of covariance and the association with prediabetes or T2DM risks was examined by logistic regression models. Our data showed increased levels of hypersensitivity C-reactive protein (hs-CRP), interleukin (IL-4), IL-10, and tryptase in prediabetes subjects and hs-CRP, immunoglobulin E (IgE), IL-4, and IL-10 in T2DM sub...

Robust control design for the plasma horizontal position control on J-TEXT Tokamak

International Nuclear Information System (INIS)

Yu, W.Z.; Chen, Z.P.; Zhuang, G.; Wang, Z.J.

2013-01-01

It is extremely important for tokamak to control the plasma position during routine discharge. However, the model of plasma in tokamak usually contains much of the uncertainty, such as structured uncertainties and unmodeled dynamics. Compared with the traditional PID control approach, robust control theory is more suitable to handle this problem. In the paper, we propose a H ∞ robust control scheme to control the horizontal position of plasma during the flat-top phase of discharge on Joint Texas Experimental Tokamak (J-TEXT) tokamak. First, the model of our plant for plasma horizontal position control is obtained from the position equilibrium equations. Then the H ∞ robust control framework is used to synthesize the controller. Based on this, an H ∞ controller is designed to minimize the regulation/tracking error. Finally, a comparison study is conducted between the optimized H ∞ robust controller and the traditional PID controller in simulations. The simulation results of the H ∞ robust controller show a significant improvement of the performance with respect to those obtained with traditional PID controller, which is currently used on our machine

Asymmetric Dimethylarginine Plasma Levels and Endothelial Function in Newly Diagnosed Type 2 Diabetic Patients

Directory of Open Access Journals (Sweden)

Francesco Perticone

2012-10-01

Full Text Available It is now well established that major risk factors for cardiovascular diseases (CVD impact upon endothelial function by decreasing nitric oxide (NO bioavailability. Asymmetric dimethylarginine (ADMA, an endogenous analog of l-arginine, is able to inhibit the activity of endothelial-NO synthase, promoting endothelial dysfunction. Type 2 diabetes (T2D is characterized by a reduced endothelium-dependent vasodilation and increased ADMA levels and ADMA is strongly associated with micro- and macrovascular diabetic complications. However, there are not a lot of data about the role of ADMA on endothelial function in newly diagnosed T2D patients without cardiovascular (CV complications. For this aim, we have enrolled forty-five newly diagnosed T2D patients, evaluated by a oral glucose tolerance test, and thirty normal subjects. Endothelium-dependent and -independent vasodilatation was investigated by intra-arterial infusion of increasing doses of acetylcholine (ACh and sodium nitroprusside. ADMA was measured by high-performance liquid chromatography and insulin resistance (IR by HOMA. Newly diagnosed T2D patients showed higher ADMA and l-arginine mean values in comparison with normal subjects and a significantly reduced ACh-stimulated forearm blood flow (FBF. In T2D patients FBF was significantly and inversely correlated with ADMA (r = −0.524, p < 0.0001 and in a multivariate regression analysis, ADMA resulted the stronger predictor of FBF, explaining the 27.5% of variability (p < 0.0001. In conclusion, ADMA was strongly related to endothelial dysfunction also in patients with newly diagnosed T2D, without clinically manifest vascular complications. This field is of great interest for understanding the mechanisms underlying the pathogenesis of diabetic disease and its CV complications.

Horizontal steam generator thermal-hydraulics

Energy Technology Data Exchange (ETDEWEB)

Ubra, O. [SKODA Praha Company, Prague (Czechoslovakia); Doubek, M. [Czech Technical Univ., Prague (Czechoslovakia)

1995-09-01

Horizontal steam generators are typical components of nuclear power plants with pressure water reactor type VVER. Thermal-hydraulic behavior of horizontal steam generators is very different from the vertical U-tube steam generator, which has been extensively studied for several years. To contribute to the understanding of the horizontal steam generator thermal-hydraulics a computer program for 3-D steady state analysis of the PGV-1000 steam generator has been developed. By means of this computer program, a detailed thermal-hydraulic and thermodynamic study of the horizontal steam generator PGV-1000 has been carried out and a set of important steam generator characteristics has been obtained. The 3-D distribution of the void fraction and 3-D level profile as functions of load and secondary side pressure have been investigated and secondary side volumes and masses as functions of load and pressure have been evaluated. Some of the interesting results of calculations are presented in the paper.

Danish Centre for Strategic Research in Type 2 Diabetes (DD2) project cohort of newly diagnosed patients with type 2 diabetes

DEFF Research Database (Denmark)

Christensen, Diana Hedevang; Nicolaisen, Sia Kromann; Berencsi, Klára

2018-01-01

PURPOSE: The aim of this article is to provide a detailed description of the ongoing nationwide Danish Centre for Strategic Research in Type 2 Diabetes (DD2) project cohort and biobank. The DD2 cohort continuously enrols newly diagnosed patients with type 2 diabetes (T2D) throughout Denmark...... measures and presence of complications at baseline have been reported. FUTURE PLANS: During 2016, a detailed follow-up questionnaire has been answered by 85% of initial participants, providing follow-up information on baseline variables and on presence of diabetic neuropathy. The DD2 cohort has now been...

Association of serum vitamin D3 with newly diagnosed type 2 diabetes mellitus

Directory of Open Access Journals (Sweden)

Taznuva Anwar

2018-03-01

Full Text Available Vitamin D has an important role and supposed to be a risk factor in the development of pathogenesis of type 2 diabetes mellitus by affecting either insulin sensitivity or β-cell function, or both. The present study was conducted to evaluate the relation of serum vitamin D3  and type 2 diabetes mellitus. Total 80 individuals were enrolled in this study. Forty newly diagnosed type 2 diabetic individual were enrolled as cases and 40 healthy glucose tolerant subjects were enrolled as controls. Serum vitamin D3 was measured by chemiluminescence microparticle immunoassay. Fasting and 2 hours plasma glucose level were measured by hexokinase method using the Dimension clinical chemistry system. The mean serum vitamin D3 level was significantly low in type 2 diabetes mellitus than in controls (p= 0,007. The individual with vitamin D3 deficiency showed 3.4 times higher chances to develop type 2 diabetes mellitus compare to the individual with normal vitamin D status. Correlation test showed significant (r= -0.351 negative correlation (p=0.026  between serum vitamin D3 and type 2 diabetes mellitus. It can be concluded that vitamin D3 deficiency is related to type 2 diabetes mellitus.

Association between High Fat-low Carbohydrate Diet Score and Newly Diagnosed Type 2 Diabetes in Chinese Population

NARCIS (Netherlands)

Na, Y.; Feskens, E.J.M.; Li, Y.P.; Zhang, J.; Fu, P.; Ma, G.S.; Yang, X.G.

2012-01-01

Objective To study the association between high fat-low carbohydrate diet score and newly diagnosed type 2 diabetes in Chinese population. Methods Data about 20 717 subjects aged 45-59 years from the cross-sectional 2002 China National Nutrition and Health Survey were analyzed. High fat-low

A Newly Designed Tennis Elbow Orthosis With a Traditional Tennis Elbow Strap in Patients With Lateral Epicondylitis

Science.gov (United States)

Saremi, Hossein; Chamani, Vahid; Vahab-Kashani, Reza

2016-01-01

Background Lateral epicondylitis is a common cause of pain and upper limb dysfunction. The use of counterforce straps for treatment of lateral epicondylitis is widespread. This kind of orthosis can be modified to have a greater effect on relieving pain by reducing tension on the origin of the extensor pronator muscles. Objectives To determine the immediate effects of a newly designed orthosis on pain and grip strength in patients with lateral epicondylitis. Materials and Methods Twelve participants (six men and six women) were recruited (mean age = 41 ± 6.7 years) and evaluated for pain and grip strength in three sessions. A 48-hour break was taken between each session. The first session was without any orthosis, the second session was with the new modified tennis elbow orthosis, and the third session was with a conventional tennis elbow strap. Results Both counterforce straps were effective. However, significantly more improvement was observed in pain and grip strength after using the newly modified orthosis (P < 0.05). Conclusions The newly designed strap reduces pain more effectively and improves grip strength by causing greater localized pressure on two regions with different force applications (two component vectors versus one). PMID:28180116

A Newly Designed Tennis Elbow Orthosis With a Traditional Tennis Elbow Strap in Patients With Lateral Epicondylitis.

Science.gov (United States)

Saremi, Hossein; Chamani, Vahid; Vahab-Kashani, Reza

2016-07-01

Lateral epicondylitis is a common cause of pain and upper limb dysfunction. The use of counterforce straps for treatment of lateral epicondylitis is widespread. This kind of orthosis can be modified to have a greater effect on relieving pain by reducing tension on the origin of the extensor pronator muscles. To determine the immediate effects of a newly designed orthosis on pain and grip strength in patients with lateral epicondylitis. Twelve participants (six men and six women) were recruited (mean age = 41 ± 6.7 years) and evaluated for pain and grip strength in three sessions. A 48-hour break was taken between each session. The first session was without any orthosis, the second session was with the new modified tennis elbow orthosis, and the third session was with a conventional tennis elbow strap. Both counterforce straps were effective. However, significantly more improvement was observed in pain and grip strength after using the newly modified orthosis (P < 0.05). The newly designed strap reduces pain more effectively and improves grip strength by causing greater localized pressure on two regions with different force applications (two component vectors versus one).

Improving steamflood effectiveness by horizontal producers

Energy Technology Data Exchange (ETDEWEB)

Leonhardt, B. [Wintershall AG, Barnstorf (Germany)

2001-12-01

The Emlichheim oilfield is located in North-West-Germany on the Dutch-German border being the Southern downdip part of the Schoonebeek anticline. The field was discovered in 1943 and came on production in 1944. Since production startup, Wintershall operates the field as owner of the concession (90% share of interest) in a joint venture with Mobil Erdgas-Erdoel GmbH (10%). For more than 50 years an average crude oil production of 150.000 t/year has been maintained. Starting with huff ''n'' puff and hot water flooding in the late 60's, the first steam flood project was implemented in 1981. Further steamflood projects started in 1989, 1992, 1993, 1994 and 1998 in different areas of the field. Until 1997, only vertical production wells were drilled in the field. Wellbore stability seemed to be a major problem for drilling horizontal wells in the unconsolidated sandstone reservoir at that time. In 1999 an innovative steamflood project was started with three newly drilled horizontal producers surrounding a vertical steam injector. First results are showing a significant improvement in the performance as compared to the earlier projects and offer new chances for further development of the field. Today, the field could no longer be operated without the steam projects as roughly 95% of the field production is coming from thermal EOR. This paper gives a brief overview of the field and its production history, the planning and realization of a current steamflood project using horizontal well technology as well as its performance compared to the earlier projects. It also describes the experience of drilling horizontal wells in the unconsolidated sandstone. A brief outlook to the future field development is given. (orig.)

Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression

Directory of Open Access Journals (Sweden)

Zhelong Liu

2014-01-01

Full Text Available The goal of this study is to investigate the association between oxidative stress and telomere length shortening in the comorbid depression and diabetes. Therefore, 71 patients with newly diagnosed type 2 diabetes (T2D and 52 subjects with normal glycemic level (control, Ctrl were enrolled. Depressive status was identified with the Depression Subscale of Hospital Anxiety and Depression Scale (HADS-D. Leukocyte telomere length ratio (T/S ratio was determined with quantitative PCR. Oxidative stress status was evaluated with 8-hydroxy-desoxyguanosine (8-OHdG assay kit. Some other biochemical blood testing was also performed. The data showed that T2D patients had higher proportion of depression evaluated by the HADS-D (x2=4.196, P=0.041. T/S ratio was significantly negatively correlated with 8-OHdG, HADS-D, age, HbA1c, FPG, and HOMA-IR. In addition, HADS-D was significantly positively correlated with HbA1c, FPG, HOMA-IR, and 8-OHdG. Both HADS-D and 8-OHdG were the major independent predictors for T/S ratio. This study indicates that oxidative stress contributes to both telomere length shortening and depression development in newly diagnosed type 2 diabetic patients, while in depression status, some other mechanisms besides oxidative stress may also affect the telomere length.

Effects of Mediterranean diet on sexual function in people with newly diagnosed type 2 diabetes: The MÈDITA trial.

Science.gov (United States)

Maiorino, Maria Ida; Bellastella, Giuseppe; Caputo, Mariangela; Castaldo, Filomena; Improta, Maria Rosaria; Giugliano, Dario; Esposito, Katherine

To assess the long-term effect of Mediterranean diet, as compared with low-fat diet, on sexual function in patients with newly diagnosed type 2 diabetes. In a randomized clinical trial, with a total follow-up of 8.1years, 215 men and women with newly diagnosed type 2 diabetes were assigned to Mediterranean diet (n=108) or a low-fat diet (n=107). The primary outcome measures were changes of erectile function (IIEF) in diabetic men and of female sexual function (FSFI) in diabetic women. There was no difference in baseline sexual function in men (n=54 vs 52) or women (n=54 vs 55) randomized to Mediterranean diet or low-fat diet, respectively (P=0.287, P=0.815). Over the entire follow-up, the changes of the primary outcomes were significantly lower in the Mediterranean diet group compared with the low-fat group: IIEF and FSFI showed a significantly lesser decrease (1.22 and 1.18, respectively, P=0.024 and 0.019) with the Mediterranean diet. Baseline C-reactive protein levels predicted erectile dysfunction in men but not female sexual dysfunction in women. Among persons with newly diagnosed type 2 diabetes, a Mediterranean diet reduced the deterioration of sexual function over time in both sexes. Copyright © 2016 Elsevier Inc. All rights reserved.

Overview of Appalachian Basin high-angle and horizontal air and mud drilling

International Nuclear Information System (INIS)

Yost, A.B. III; Javins, B.H.

1991-01-01

The United States Department of Energy's Morgantown Energy Technology Center has been investigating the potential of using high angle and horizontal drilling technology to improve gas production from low permeability reservoirs for more than 20 years. A chronology of 45 high angle and horizontal wells have been identified to show the date, type well, type build curve, location, formation and the type of application. The historical well drilling events that have taken place since the first well are discussed to evaluate the progress in developing the technology. Detailed discussion about how the drilling technology developed in the Appalachian Basin for directional drilling and completion was provided. A discussion of the types of applications for high and horizontal drilling in the Appalachian Basin were identified. A summary of four jointly funded DOE/Industry horizontal wells were discussed to illustrate how the air horizontal drilling technology developed and learning curves for drilling cost and feet per day were provided to illustrate the improvement in the technology and equipment reliability

Pressure suppression pool hydrodynamic studies for horizontal vent exit of Indian PHWR containment

International Nuclear Information System (INIS)

Mohan, N.; Bajaj, S.S.; Saha, P.

1994-01-01

The standard Indian PHWR incorporates a pressure suppression type of containment system with a suppression pool.The design of KAPS (Kakrapar Atomic Power Station) suppression pool system adopts a modified system of downcomers having horizontal vents as compared to vertical vents of NAPS (Narora Atomic Power Station). Hydrodynamic studies for vertical vents have been reported earlier. This paper presents hydrodynamic studies for horizontal type vent system during LOCA. These studies include the phenomenon of vent clearing (where the water slug standing in downcomer initially is injected to wetwell due to rapid pressurization of drywell) followed by pool swell (elevation of pool water due to formation of bubbles due to air mass entering pool at the exit of horizontal vents from drywell). The analysis performed for vent clearing and pool swell is based on rigorous thermal hydraulic calculation consisting of conservation of air-steam mixture mass, momentum and thermal energy and mass of air. Horizontal vent of downcomer is modelled in such a way that during steam-air flow, variation of flow area due to oscillating water surface in downcomer could be considered. Calculation predicts that the vent gets cleared in about 1.0 second and the corresponding downward slug velocity in the downcomer is 4.61 m/sec. The maximum pool swell for a conservative lateral expansion is calculated to be 0.56 m. (author). 3 refs., 12 figs

Real-time PCR detection of Fe-type nitrile hydratase genes from environmental isolates suggests horizontal gene transfer between multiple genera.

Science.gov (United States)

Coffey, Lee; Owens, Erica; Tambling, Karen; O'Neill, David; O'Connor, Laura; O'Reilly, Catherine

2010-11-01

Nitriles are widespread in the environment as a result of biological and industrial activity. Nitrile hydratases catalyse the hydration of nitriles to the corresponding amide and are often associated with amidases, which catalyze the conversion of amides to the corresponding acids. Nitrile hydratases have potential as biocatalysts in bioremediation and biotransformation applications, and several successful examples demonstrate the advantages. In this work a real-time PCR assay was designed for the detection of Fe-type nitrile hydratase genes from environmental isolates purified from nitrile-enriched soils and seaweeds. Specific PCR primers were also designed for amplification and sequencing of the genes. Identical or highly homologous nitrile hydratase genes were detected from isolates of numerous genera from geographically diverse sites, as were numerous novel genes. The genes were also detected from isolates of genera not previously reported to harbour nitrile hydratases. The results provide further evidence that many bacteria have acquired the genes via horizontal gene transfer. The real-time PCR assay should prove useful in searching for nitrile hydratases that could have novel substrate specificities and therefore potential in industrial applications.

Response of Voronezh reactor type to horizontal ground motion

International Nuclear Information System (INIS)

Pecinka, L.

1983-01-01

For the purposes of vibration monitoring of PWR's the well known 'double pendulum model' has been developed and experimentally verified. It is shown, that this model is possible to use for response calculations of Voronezh reactor pressure vessel and its internals to horizontal ground motion. The equation of motion is given in usual matrix form, the damping matrix is calculated by Rayleigh formula. Driving force is given by vector of ground motion in horizontal direction. For the numerical integration of equation of motion is possible to use following methods - matrix exponential in state space; - modal analysis; - one-step direct integration. For our purposes the last one has been chosen and related computer code TRANS has been developed. The results of calculations are given in the graphically form using generalized angular coordinates and its second derivatives, which describes the displacement or acceleration of reactor pressure vessel to ground and the core barrel to reactor pressure vessel. The driving vector is given in the form of artificially generated accelerogram. (orig./HP)

Experimental development of a torsion arc blade type horizontal axis windmil; Nejire enko yokugata suihei jiku fusha no kaihatsu

Energy Technology Data Exchange (ETDEWEB)

Kojima, N. [Meiji Univ., Tokyo (Japan). Faculty of Scince and Technology

1996-05-31

To get more wind energy, longer rotating blades and higher towers of windmills are required. Therefore, the location of windmills is limited and the initial cost gets higher. In this study, a small size windmill which can generate electricity even in a city was developed and tested. A torsion arc blade type horizontal axis windmill was designed and the blade form, number and degree of distortion were investigated. Based on the results, a small windmill was made, rotation and generation tests were carried out and it was confirmed that the windmill could be used as a small scale wind power generation. The windmill is of simple construction having 6 arc blades and no high tower is required. This paper consists of 6 sections, i.e. Introduction, Windmill model, Tested windmill, Test facility and method, Test results and consideration, and Postscript. 2 refs., 18 figs., 1 tab.

Energy and exergy efficiency comparison of horizontal and vertical axis wind turbines

Energy Technology Data Exchange (ETDEWEB)

Pope, K.; Dincer, I.; Naterer, G.F. [Faculty of Engineering and Applied Science, University of Ontario Institute of Technology, 2000 Simcoe Street North, Oshawa, Ontario (Canada)

2010-09-15

In this paper, an energy and exergy analysis is performed on four different wind power systems, including both horizontal and vertical axis wind turbines. Significant variability in turbine designs and operating parameters are encompassed through the selection of systems. In particular, two airfoils (NACA 63(2)-215 and FX 63-137) commonly used in horizontal axis wind turbines are compared with two vertical axis wind turbines (VAWTs). A Savonius design and Zephyr VAWT benefit from operational attributes in wind conditions that are unsuitable for airfoil type designs. This paper analyzes each system with respect to both the first and second laws of thermodynamics. The aerodynamic performance of each system is numerically analyzed by computational fluid dynamics software, FLUENT. A difference in first and second law efficiencies of between 50 and 53% is predicted for the airfoil systems, whereas 44-55% differences are predicted for the VAWT systems. Key design variables are analyzed and the predicted results are discussed. The exergetic efficiency of each wind turbine is studied for different geometries, design parameters and operating conditions. It is shown that the second law provides unique insight beyond a first law analysis, thereby providing a useful design tool for wind power development. (author)

Benefits of obtaining log data in horizontal wells in the WCSB

Energy Technology Data Exchange (ETDEWEB)

Spratt, D. [Reeves Wireline Technologies Ltd., Calgary, AB (Canada)

2001-11-01

A Compact Memory Logging (CML) system developed by Reeves Wireline Technologies was presented. It can be used to obtain log data from horizontal wells to get a better understanding of how to enhance production or completion techniques. The methods that are commonly used to obtain data from horizontal wells include measurement while drilling (MWD), logging while drilling (LWD), wet connect pipe conveyed wireline logging and CML. Each method has its unique benefits that range from information on lithology, rock parameters and fluid interfaces. Reeves has been using wireless pipe conveyed CML over the past two years. The log data includes array induction, dual spaced neutron and photo density porosity, Pe, gamma ray, compensated sonic and hose size caliper. Reeves CML is smaller, easily conveyed and has an unprecedented capability to bend and is considered to be well suited for both newly and previously drilled horizontal wells that require remedial assessment. The tool can be used to determine reservoir quality and boundaries, establish zone structures, or identify fluid interfaces for strategic planning of completions and stimulations. This paper presented examples of logs on some horizontal wells that indicate the value of obtaining log data. Reeves CML is considered to be economically and operationally ideal, particularly since data from the CML includes depth of investigation. 5 figs.

QUALITATIVE ANALYSIS OF DEPENDENCE OF DRIVE POWER HORIZONTAL-INCLINED BELT CONVEYOR ON ITS INITIAL PARAMETERS

Directory of Open Access Journals (Sweden)

V. M. Bohomaz

2017-02-01

Full Text Available Purpose.One of the main elements of band conveyors is a drive. To analyze the effect of design parameters on the drive power it is necessary to carry out the calculations according to standard procedures outlined in the current technical literature. The main design parameters of the band conveyor are: the type of cargo, project performance, the geometric dimensions of sections and track configuration as a whole. The feature of band conveyor calculation as compared to the elevators is the dependence of the band width on its performance, the inclination angle and the type of cargo. In the article for the account of this fact during calculations it is necessary to construct the dependence of the band width on the generalized parameter, which takes into account change in the design parameters. To determine the general pattern of changing the value of band conveyor drive power when varying its design parameters in the article it is necessary to construct the corresponding graphic dependences taking into account the standard sizes and bands parameters. Methodology. We consider the band conveyor with two sections: the inclined and horizontal one. It is conducted a detailed analysis of dependence of the conveyor band width and its drive power on the type of cargo, project performance, geometric dimensions and configuration of the conveyor track, using the appropriate parameter dependences constructed by the authors in previous papers. Findings. For band conveyors of this type there were constructed the graphics dependences of the band width on the parameter characterizing the project performance and the inclination angle of the track section, and on the performance at a fixed angle of inclination. Taking into account the changes in the band width with an increase in the value of project performance the graph dependences of drive power on the productivity and the inclination angle of the inclined section were built. Originality. For the first time there

Effectiveness of a diabetes education and self management programme (DESMOND) for people with newly diagnosed type 2 diabetes mellitus

DEFF Research Database (Denmark)

Khunti, Kamlesh; Gray, Laura J.; Skinner, Timothy

2012-01-01

Objective: To measure whether the benefits of a single education and self management structured programme for people with newly diagnosed type 2 diabetes mellitus are sustained at three years. Design: Three year follow-up of a multicentre cluster randomised controlled trial in primary care....... Intervention: A structured group education programme for six hours delivered in the community by two trained healthcare professional educators compared with usual care. Main outcome measures: The primary outcome was glycated haemoglobin (HbA1c) levels. The secondary outcomes were blood pressure, weight, blood...... lipid levels, smoking status, physical activity, quality of life, beliefs about illness, depression, emotional impact of diabetes, and drug use at three years. Results: HbA1c levels at three years had decreased in both groups. After adjusting for baseline and cluster the difference was not significant...

Dynamic deuteron polarization measurements performed in a new type of horizontal dilution cryostat

International Nuclear Information System (INIS)

Meyer, W.; Althoff, K.H.; Kaul, O.; Riechert, H.; Schilling, E.

1982-05-01

We have reached 31% deuteron polarization in D- ammonia (ND 3 ) and 27% in D- butanol (C 4 D 10 O). The dynamic polarization experiments were performed at a magnetic field of 2.5 T in a new type of horizontal dilution cryostat. This dilution cryostat, built for target asymmetry measurements with a photon beam, was developed with special regard to fast cool-down and easy loading of the target material. The cooling power is 5 mW at 0.2 K, 20 mW at 0.3 K and 34 mW at 0.4 K. Starting from room temperature the lowest temperature of 165 mK is reached in about 2 h including the loading of the target material. (orig.)

DESIGN AND IMPLEMENTATION OF A CO2 FLOOD UTILIZING ADVANCED RESERVOIR CHARACTERIZATION AND HORIZONTAL INJECTION WELLS IN A SHALLOW SHELF CARBONATE APPROACHING WATERFLOOD DEPLETION

Energy Technology Data Exchange (ETDEWEB)

K.J. Harpole; Ed G. Durrett; Susan Snow; J.S. Bles; Carlon Robertson; C.D. Caldwell; D.J. Harms; R.L. King; B.A. Baldwin; D. Wegener; M. Navarrette

2002-09-01

The purpose of this project was to economically design an optimum carbon dioxide (CO{sub 2}) flood for a mature waterflood nearing its economic abandonment. The original project utilized advanced reservoir characterization and CO{sub 2} horizontal injection wells as the primary methods to redevelop the South Cowden Unit (SCU). The development plans; project implementation and reservoir management techniques were to be transferred to the public domain to assist in preventing premature abandonment of similar fields. The Unit was a mature waterflood with water cut exceeding 95%. Oil must be mobilized through the use of a miscible or near-miscible fluid to recover significant additional reserves. Also, because the unit was relatively small, it did not have the benefit of economies of scale inherent in normal larger scale projects. Thus, new and innovative methods were required to reduce investment and operating costs. Two primary methods used to accomplish improved economics were use of reservoir characterization to restrict the flood to the higher quality rock in the unit and use of horizontal injection wells to cut investment and operating costs. The project consisted of two budget phases. Budget Phase I started in June 1994 and ended late June 1996. In this phase Reservoir Analysis, Characterization Tasks and Advanced Technology Definition Tasks were completed. Completion enabled the project to be designed, evaluated, and an Authority for Expenditure (AFE) for project implementation submitted to working interest owners for approval. Budget Phase II consisted of the implementation and execution of the project in the field. Phase II was completed in July 2001. Performance monitoring, during Phase II, by mid 1998 identified the majority of producing wells which under performed their anticipated withdrawal rates. Newly drilled and re-activated wells had lower offtake rates than originally forecasted. As a result of poor offtake, higher reservoir pressure was a concern

Design of an X-band accelerating structure using a newly developed structural optimization procedure

Energy Technology Data Exchange (ETDEWEB)

Huang, Xiaoxia [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Fang, Wencheng; Gu, Qiang [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China); Zhao, Zhentang, E-mail: zhaozhentang@sinap.ac.cn [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China); University of Chinese Academy of Sciences, Beijing 100049 (China)

2017-05-11

An X-band high gradient accelerating structure is a challenging technology for implementation in advanced electron linear accelerator facilities. The present work discusses the design of an X-band accelerating structure for dedicated application to a compact hard X-ray free electron laser facility at the Shanghai Institute of Applied Physics, and numerous design optimizations are conducted with consideration for radio frequency (RF) breakdown, RF efficiency, short-range wakefields, and dipole/quadrupole field modes, to ensure good beam quality and a high accelerating gradient. The designed X-band accelerating structure is a constant gradient structure with a 4π/5 operating mode and input and output dual-feed couplers in a racetrack shape. The design process employs a newly developed effective optimization procedure for optimization of the X-band accelerating structure. In addition, the specific design of couplers providing high beam quality by eliminating dipole field components and reducing quadrupole field components is discussed in detail.

HORIZONTAL AXIS MARINE CURRENT TURBINE DESIGN FOR WIND-ELECTRIC HYBRID SAILING BOAT

Directory of Open Access Journals (Sweden)

Serkan Ekinci

2017-01-01

Full Text Available In recent decades, the number of theoretical studies and applications on electric power production from renewable sources such as wind, solar, sea and tidal flows, has been increasing rapidly. Marine Current Turbines (MCTs, among the power turbines, produce power from alternating flows and are a means of power production even at lower flow rates in oceans and seas. In this study, while maintaining functional requirements, an initial and detailed design (mechanic and hydrodynamic, of an MCT fixed on a sailing boat and at sail which extracts power from the flow around the boat, is undertaken. In the design stages, for analysis and optimization of the marine turbine blade design, the Momentum Blade Element Method is utilized. The Horizontal Axis Marine Turbine (HAMT, determined by the initial and mechanical design, is illustrated with its components included. Computational fluid dynamics (CFD analyses, covering turbine pod geometry at required flow rates and turbine speeds are performed. These analyses are performed very close to real conditions, considering sailing with and without the turbine running (on and off states. The alternator is determined from the results, and the final design which meets the design requirements, is obtained. As a result, a user friendly and innovative turbine design for sail boats, offering more power and efficiency, which is longer lasting compared to solar and wind technologies, that also makes use of renewable sources, such as wind and/or solar, and in addition stores and uses accumulated energy when needed, is proposed.

The development of Canadian leadership in horizontal drilling technology

Energy Technology Data Exchange (ETDEWEB)

Hawkins, J R

1989-01-01

Horizontal wells are of increasing interest in the oil and gas industry, as is evident from the increase in the numbers of such wells being drilled. Horizontal well technology is used to improve production rates, notably in low permeability formations; to capture reserves if a reservoir is not economic using non-horizontal wells; to manage breakthrough of sweep fluids and increase sweep efficiency; and to extend the areal reach from a single surface location, especially in offshore production. The types of horizontal wells, differentiated on the basis of how quickly the well becomes horizontal, are briefly outlined and a short history of horizontal wells is presented. Canadian accomplishments in this field are then described, including steerable drilling systems, measurement-while-drilling systems, management of hole drag and torque, and well completion techniques. About 25 horizontal wells are forecast to be drilled in Canada in 1989, indicating the favorable future of this technology. 2 figs., 5 tabs.

Real-time horizontal position control for Aditya-upgrade tokamak

International Nuclear Information System (INIS)

Kumar, Rohit; Ghosh, Joydeep; Tanna, Rakesh L.

2015-01-01

Position of plasma column is required to be controlled in real time for improved operation of any tokamak. A PID based system for real-time horizontal plasma position control has been designed for Aditya Upgrade tokamak. Modelling of transfer functions of actuators, plasma and diagnostic system are carried out for ADITYA-U tokamak. The PID controller is optimized using MATLAB-SIMULINK for horizontal position control. Further feed-forward loop is implemented where disturbance due to density variation is suppressed, which results in improved performance as compared to conventional PID operation. In this paper the detailed design of the whole system for real time control of plasma horizontal position in Aditya Upgrade tokamak is presented. (author)

Dairy product consumption is associated with pre-diabetes and newly diagnosed type 2 diabetes in the Lifelines Cohort Study

NARCIS (Netherlands)

Brouwer, E.M.; Sluik, D.; Singh-Povel, C.M.; Feskens, E.J.M.

2018-01-01

Previous studies show associations between dairy product consumption and type 2 diabetes, but only a few studies conducted detailed analyses for a variety of dairy subgroups. Therefore, we examined cross-sectional associations of a broad variety of dairy subgroups with pre-diabetes and newly

Performance evaluation and solar radiation capture of optimally inclined box type solar cooker with parallelepiped cooking vessel design

International Nuclear Information System (INIS)

Sethi, V.P.; Pal, D.S.; Sumathy, K.

2014-01-01

Highlights: • Optimally inclined solar cooker is presented for efficient cooking. • A new parallelepiped shaped cooking vessel for higher solar radiation capture is presented. • Optimum tilt angles of the boosted mirror are computed for maximization of reflected components. • Solar radiation capture ratios show the better cooking performance of inclined cooker. • Standard performance parameters establish the better cooking performance of inclined cooker. - Abstract: An optimally inclined box type solar cooker with single booster mirror is presented along with design and development of a novel parallelepiped shaped cooking vessel design for efficient cooking especially in winter conditions. The main feature of new parallelepiped shaped design is its longer inclined south wall (facing the sun) and a trapezoidal cavity on the vessel lid for greater heat transfer to the food material. The ends of the vessel towards east and west direction are minimized. The cooking performance parameters of proposed inclined cooker coupled with new vessel design were compared with horizontally placed identical cooker of same material and dimensions coupled with conventional cylindrical vessel design during winter month (January) of the year 2010 at Ludhiana climate (30°N 77°E), India. Results showed that the first and the second figures of merit (F 1 and F 2 ) for inclined cooker were 0.16 and 0.54 as compared to 0.14 and 0.43 for horizontally placed cooker. Time taken to boil the water τ boil and standard cooking power P n was 37% less and 40% more respectively in parallelepiped shaped cooking vessel of inclined cooker as compared to conventional cylindrical vessel of horizontally placed cooker. A mathematical model is developed to compute the total solar radiation availability on the absorber plate of inclined as well as horizontal cooker which establishes the better cooking performance of the inclined cooker due to greater width of sun rays intercepting the absorber

Innovative approach to computer-aided design of horizontal axis wind turbine blades

Directory of Open Access Journals (Sweden)

Seyed Farhad Hosseini

2017-04-01

Full Text Available The design of horizontal axis wind turbine (HAWT blades involves several geometric complexities. As a result, the modeling of these blades by commercial computer-aided design (CAD software is not easily accomplished. In the present paper, the HAWT blade is divided into structural and aerodynamic surfaces with a G1 continuity imposed on their connecting region. The widely used method of skinning is employed throughout the current work for surface approximation. In addition, to ensure the compatibility of section curves, a novel approach is developed based on the redistribution of input airfoil points. In order to evaluate deviation errors, the Hausdorff metric is used. The fairness of surfaces is quantitatively assessed using the standard strain energy method. The above-mentioned algorithms are successfully integrated into a MATLAB program so as to enhance further optimization applications. The final surfaces created by the procedure developed during the present study can be exported using the IGES standard file format and directly interpreted by commercial CAD and FE software.

Horizontal violence in Nursing

Directory of Open Access Journals (Sweden)

Tsimoulaki Evangelia

2017-01-01

Full Text Available One’s effort to clarify the definition of horizontal labour violence is of great importance, due to the variety of definitions that are mentioned in the worldwide scientific literature. Furthermore, the reference of multiple forms of such violence herein the nurse professional group is challenging, as well. Another fact of great importance is that, any form of professional violence (horizontal violence, horizontal mobbing in the work place environment can be possibly escalated and include even physical abuse (Bullying, besides the psychological and emotional impact for the victim. The definitions of Horizontal violence, Mobbing and Bullying, include a repeated negative behaviour emanating from at least one “predator” towards at least one “victim”, with work status differences and the existence or lack of physical abuse (Bullying. Horizontal violence is a hostile, aggressive and harmful behaviour which is either overt or concealed and is pointed from an individual to another individual of the same working rank and causes intense emotional pain at the victim. The manifestations vary from humiliating tasks assignment or the victim’s efforts undermining to clearly aggressive behaviors (criticism, intimidation, sarcasm etc.. The reason behind this phenomenon is multifactorial extended not only towards the working environment but also to the personal characteristics of the “predator” as well as the possible “victim”. The researchers emphasize the high incidence of the phenomenon, as well as the cost that is induced by the violent behaviors to both the health professionals and the hospital. Finally, they point out the paradox of the presence of violence inside a system that is designed to promote health.

Healthcare professionals' views of group structured education for people with newly diagnosed Type 2 diabetes.

Science.gov (United States)

Winkley, K; Upsher, R; Keij, S M; Chamley, M; Ismail, K; Forbes, A

2018-04-06

To determine healthcare professionals' (HCP) views of group structured education for people with newly diagnosed Type 2 diabetes. This was a qualitative study using semi-structured interviews to ascertain primary care HCPs' views and experiences of education for people with newly diagnosed Type 2 diabetes. A thematic framework method was applied to analyse the data. Participants were HCPs (N = 22) from 15 general practices in three south London boroughs. All but one HCP viewed diabetes education favourably and all identified that low attendance was a problem. Three key themes emerged from the qualitative data: (1) benefits of diabetes education, including the group mode of delivery, improved patient interactions, saving HCPs' time and improved patient outcomes; (2) factors limiting uptake of education, including patient-level problems such as access and the appropriateness of the programme for certain groups, and difficulties communicating the benefits to patients and integration of education management plans into ongoing diabetes care; and (3) suggestions for improvement, including strategies to improve attendance at education with more localized and targeted marketing and enhanced programme content including follow-up sessions and support for people with pre-existing psychological issues. Most HCPs valued diabetes education and all highlighted the lack of provision for people with different levels of health literacy. Because there was wide variation in terms of the level of knowledge regarding the education on offer, future studies may want to focus on how to help HCPs encourage their patients to attend. © 2018 Diabetes UK.

Practical calibration of design data to technical capabilities of horizontal directional drilling rig

Science.gov (United States)

Toropov, S. Yu; Toropov, V. S.

2018-05-01

In order to design more accurately trenchless pipeline passages, a technique has been developed for calculating the passage profile, based on specific parameters of the horizontal directional drilling rig, including the range of possible drilling angles and a list of compatible drill pipe sets. The algorithm for calculating the parameters of the trenchless passage profile is shown in the paper. This algorithm is based on taking into account the features of HDD technology, namely, three different stages of production. The authors take into account that the passage profile is formed at the first stage of passage construction, that is, when drilling a pilot well. The algorithm involves calculating the profile by taking into account parameters of the drill pipes used and angles of their deviation relative to each other during the pilot drilling. This approach allows us to unambiguously calibrate the designed profile for the HDD rig capabilities and the auxiliary and navigation equipment used in the construction process.

Performance of A Horizontal Cylinder Type Rotary Dryer for Drying Process ofOrganic Compost from Solid Waste Cocoa Pod

Directory of Open Access Journals (Sweden)

Sukrisno Widyotomo

2008-07-01

Full Text Available Cocoa pod husk is the bigest component of cocoa pod, about 70% of total ht of mature pod, and to potentially used as organic compost source. Poten tial solid waste of cocoa pod husk from a cocoa processing centre is about 15— 22 m3/ha/year. A cocoa plantation needs about 20—30 ton/ha/year of organic matters. One of important steps in compos processing technology of cocoa pod solid waste is drying process. Organic compost with 20% moisture content is more easy in handling, application, storage and distribution. Indonesian Coffee and Cocoa Research Institute has designed and tested a horizontal cylinder type rotary dryer for drying process of organic compos from solid waste cocoa pod with kerosene burner as energy sources. The objective of this research is to study performance of a horizontal cylinder type rotary dryer using kerosene burner as energy source for drying process of organic compost from solid waste cocoa pod. The material used was solid waste cocoa pod with 70—75% moisture content (wet basis, 70% size particle larger than 4.76 mm, and 30% size particle less than 4.76 mm, 690—695 kg/m3 bulk density. Drying process temperatures treatment were 60OC, 80OC, and 100OC, and cylinder rotary speed treatments were 7 rpm, 10 rpm, dan 16 rpm. The results showed that dryer had capacity about 102—150 kg/h depend on drying temperature and cylinder rotary speed. Optimum operation condition at 100OC drying temperature, and 10 rpm cylinder rotary speed with drying time to reach final moisture content of 20% was 1,6 h, capacity 136,14 kg/ h, bulk density 410 kg/m3, porocity 45,15%, kerosene consumption as energy source was 2,57 l/h, and drying efficiency 68,34%. Key words : cocoa, drying, rotary dryer, compost, waste

Mechanism and application of a newly developed pressure casting process: horizontal squeeze casting

Directory of Open Access Journals (Sweden)

Li Peijie

2014-07-01

Full Text Available Compared to traditional high-pressure die casting (HPDC, horizontal squeeze casting (HSC is a more promising way to fabricate high-integrity castings, owing to a reduced number of gas and shrinkage porosities produced in the casting. In this paper, the differences between HSC and HPDC are assessed, through which it is shown that the cavity filling velocity and the size of the gating system to be the most notable differences. Equipment development and related applications are also reviewed. Furthermore, numerical simulation is used to analyze the three fundamental characteristics of HSC: slow cavity filling, squeeze feeding and slow sleeve filling. From this, a selection principle is given based on the three related critical casting parameters: cavity filling velocity, gate size and sleeve filling velocity. Finally, two specific applications of HSC are introduced, and the future direction of HSC development is discussed.

Potential for horizontal well technology in the U.S

International Nuclear Information System (INIS)

Biglarbigi, K.; Mohan, H.; Ray, R.M.; Meehan, D.N.

2000-01-01

In the past decade, the use of horizontal well technology has increased significantly in the U.S., contributing to the drilling of 600 to 1000 horizontal oil wells annually. A total of 86 per cent of the existing horizontal wells have been drilled in three formations, the Austin chalk in Texas, the Bakken shale in North Dakota, and the Niobrara in Colorado and Wyoming. A unique analytical system has been developed by the United States Department of Energy, National Petroleum Technology Office (USDOE/NPTO) to assess the potential for greater use of horizontal well technology for other oil resources in other geological formations. The analytical system is designed to be used in association with other enhanced recovery methods that make up the DOE's Total Oil Recovery Information System (TORIS). The DOE/NPTO collaborated with industry to identify the target resource for horizontal well technology and to evaluate its future recovery potential under different economic and technological conditions. This paper provides a national summary of the potential for additional production and reserves with more diverse application of horizontal wells in various types of U.S. oil resources, including the rest of the fractured reservoirs in the Austin chalk, other fractured reservoirs in the north and northwestern states, thin-bed reservoirs, and mature waterflood field. The results were presented in terms of production, reserves and national economic benefits with a full cash-flow analysis at oil prices in the range of $16 to $24 U.S. per bbl. It is estimated that 541 million to 1 billion bbls of new reserves are economically producible at these prices. The reserves estimates pertain to future horizontal wells in known fields only and are in addition to the reserves for the existing wells as of 1 January 1998. Potential production is substantial, ranging from 50 million to 85 million bbl per year by 2004 and then declining at a rate of 8 per cent per year in the following years

Type VI Secretion System Toxins Horizontally Shared between Marine Bacteria.

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Dor Salomon

2015-08-01

Full Text Available The type VI secretion system (T6SS is a widespread protein secretion apparatus used by Gram-negative bacteria to deliver toxic effector proteins into adjacent bacterial or host cells. Here, we uncovered a role in interbacterial competition for the two T6SSs encoded by the marine pathogen Vibrio alginolyticus. Using comparative proteomics and genetics, we identified their effector repertoires. In addition to the previously described effector V12G01_02265, we identified three new effectors secreted by T6SS1, indicating that the T6SS1 secretes at least four antibacterial effectors, of which three are members of the MIX-effector class. We also showed that the T6SS2 secretes at least three antibacterial effectors. Our findings revealed that many MIX-effectors belonging to clan V are "orphan" effectors that neighbor mobile elements and are shared between marine bacteria via horizontal gene transfer. We demonstrated that a MIX V-effector from V. alginolyticus is a functional T6SS effector when ectopically expressed in another Vibrio species. We propose that mobile MIX V-effectors serve as an environmental reservoir of T6SS effectors that are shared and used to diversify antibacterial toxin repertoires in marine bacteria, resulting in enhanced competitive fitness.

The blind faith deep water horizontal pipeline tie-in project

Energy Technology Data Exchange (ETDEWEB)

Charalambides, John Nicos [Oceaneering International, Inc., Houston, TX (United States)

2009-12-19

This presentation will concentrate on the design challenges, experience and learning from the SIT and offshore installation of two deepwater pipeline tie-ins using first-of-its-kind subsea technology and installation methodologies on the 'Blind Faith' project. The Blind Faith Subsea Tie-Ins join the Blind Faith oil and gas pipelines with the Canyon Chief gas pipeline and the Mountaineer oil pipeline in 5100 feet of water. Both of the Blind Faith oil and gas pipelines are terminated with conventional PLEMs providing a horizontal connector for the tie-in and a vertical connector for a future tie-in connection point. The connectors are ROV operable/installable clamp style connectors. The method of joining to the Canyon Chief oil and gas pipelines and the type of jumper employed are unique to the tie-in. An ROV operable / installable mechanical pipe end connector connects the bare ends of the Canyon Chief and Mountaineer pipelines. The mechanical pipe end connector is fitted with an integral clamp connector hub and rests on an ROV installed mud mat. After installation of the mechanical connector, metrology was performed to create a neutral state horizontal jumper for joining the mechanical connector hub and the Blind Faith PLEM. The neutral state horizontal jumper is a compliant 'Z-Bend' design. During installation the jumper was elastically pre-deformed using a bowstring system. Pre-deformation of the jumper provided installation clearances and facilitated the neutral stress state after installation. Once landed the jumper bowstring was relaxed, allowing the jumper to expand to fit between the hubs. After expansion and make-up, the clamp connectors were tightened via an ROV operated hydraulic torque wrench. A seal test verified the integrity of the connections. After installation the jumper remains in a minimal residual stress state atypical of most horizontal jumpers. The horizontal jumper was chosen over the vertical jumper because it provides a

Topological properties of the limited penetrable horizontal visibility graph family

Science.gov (United States)

Wang, Minggang; Vilela, André L. M.; Du, Ruijin; Zhao, Longfeng; Dong, Gaogao; Tian, Lixin; Stanley, H. Eugene

2018-05-01

The limited penetrable horizontal visibility graph algorithm was recently introduced to map time series in complex networks. In this work, we extend this algorithm to create a directed-limited penetrable horizontal visibility graph and an image-limited penetrable horizontal visibility graph. We define two algorithms and provide theoretical results on the topological properties of these graphs associated with different types of real-value series. We perform several numerical simulations to check the accuracy of our theoretical results. Finally, we present an application of the directed-limited penetrable horizontal visibility graph to measure real-value time series irreversibility and an application of the image-limited penetrable horizontal visibility graph that discriminates noise from chaos. We also propose a method to measure the systematic risk using the image-limited penetrable horizontal visibility graph, and the empirical results show the effectiveness of our proposed algorithms.

14 CFR 21.31 - Type design.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Type design. 21.31 Section 21.31... PROCEDURES FOR PRODUCTS AND PARTS Type Certificates § 21.31 Type design. The type design consists of— (a) The... configuration and the design features of the product shown to comply with the requirements of that part of this...

Validity of a Newly-Designed Rectilinear Stepping Ergometer Submaximal Exercise Test to Assess Cardiorespiratory Fitness

OpenAIRE

Rubin Zhang, Likui Zhan, Shaoming Sun, Wei Peng, Yining Sun

2017-01-01

The maximum oxygen uptake (V̇O2 max), determined from graded maximal or submaximal exercise tests, is used to classify the cardiorespiratory fitness level of individuals. The purpose of this study was to examine the validity and reliability of the YMCA submaximal exercise test protocol performed on a newly-designed rectilinear stepping ergometer (RSE) that used up and down reciprocating vertical motion in place of conventional circular motion and giving precise measurement of workload, to det...

Inverse Design of Single- and Multi-Rotor Horizontal Axis Wind Turbine Blades using Computational Fluid Dynamics

OpenAIRE

Moghadassian, Behnam; Sharma, Anupam

2017-01-01

A method for inverse design of horizontal axis wind turbines (HAWTs) is presented in this paper. The direct solver for aerodynamic analysis solves the Reynolds Averaged Navier Stokes (RANS) equations, where the effect of the turbine rotor is modeled as momentum sources using the actuator disk model (ADM); this approach is referred to as RANS/ADM. The inverse problem is posed as follows: for a given selection of airfoils, the objective is to find the blade geometry (described as blade twist an...

Cardiovascular Risk Assessment with Vascular Function, Carotid Atherosclerosis and the UKPDS Risk Engine in Korean Patients with Newly Diagnosed Type 2 Diabetes

Directory of Open Access Journals (Sweden)

Choon Sik Seon

2011-12-01

Full Text Available BackgroundPatients with type 2 diabetes have an increased risk of cardiovascular disease. Few studies have evaluated the cardiovascular disease (CVD risk simultaneously using the United Kingdom Prospective Diabetes Study (UKPDS risk engine and non-invasive vascular tests in patients with newly diagnosed type 2 diabetes.MethodsParticipants (n=380; aged 20 to 81 years with newly diagnosed type 2 diabetes were free of clinical evidence of CVD. The 10-year coronary heart disease (CHD and stroke risks were calculated for each patient using the UKPDS risk engine. Carotid intima media thickness (CIMT, flow mediated dilation (FMD, pulse wave velocity (PWV and augmentation index (AI were measured. The correlations between the UKPDS risk engine and the non-invasive vascular tests were assessed using partial correlation analysis, after adjusting for age, and multiple regression analysis.ResultsThe mean 10-year CHD and 10-year stroke risks were 14.92±11.53% and 4.03±3.95%, respectively. The 10-year CHD risk correlated with CIMT (P<0.001, FMD (P=0.017, and PWV (P=0.35 after adjusting for age. The 10-year stroke risk correlated only with the mean CIMT (P<0.001 after adjusting for age. FMD correlated with age (P<0.01 and systolic blood pressure (P=0.09. CIMT correlated with age (P<0.01, HbA1c (P=0.05, and gender (P<0.01.ConclusionThe CVD risk is increased at the onset of type 2 diabetes. CIMT, FMD, and PWV along with the UKPDS risk engine should be considered to evaluate cardiovascular disease risk in patients with newly diagnosed type 2 diabetes.

Optimization of the key geological target parameters of shale-gas horizontal wells in the Changning Block, Sichuan Basin

Directory of Open Access Journals (Sweden)

Hongzhi Yang

2016-12-01

Full Text Available In recent years, great progress has been made in geologic evaluation, engineering test and development optimization of the Lower Cambrian Wufeng Fm–Lower Silurian Longmaxi Fm shale gas in the Sichuan Basin, and the main shale gas exploitation technologies have been understood preliminarily. In addition, scale productivity construction has been completed in Jiaoshiba, Changning and Weiyuan blocks. In this paper, the Wufeng Fm–Longmaxi Fm shale gas wells in Changning Block were taken as the study object to provide technical reference for the development design of similar shale-gas horizontal wells. The technology combining geology with engineering, dynamic with static, and statistical analysis with simulation prediction was applied to quantify the main factors controlling shale-gas well productivity, develop the shale-gas well production prediction model, and optimize the key technical parameters of geologic target of shale-gas horizontal wells in the block (e.g. roadway orientation, location and spacing, horizontal section length and gas well production index. In order to realize high productivity of shale gas wells, it is necessary to maximize the included angle between the horizontal section orientation and the maximum major stress and fracture development direction, deploy horizontal-well roadway in top-quality shale layers, and drill the horizontal section in type I reservoirs over 1000 m long. It is concluded that high productivity of shale gas wells is guaranteed by the horizontal-well wellbore integrity and the optimized low-viscosity slickwater and ceramsite fracturing technology for complex fracture creation. Based on the research results, the technical policies for shale gas development of Changning Block are prepared and a guidance and reference are provided for the shale gas development and productivity construction in the block and the development design of similar shale-gas horizontal wells.

Chromium-Containing Traditional Chinese Medicine, Tianmai Xiaoke Tablet, for Newly Diagnosed Type 2 Diabetes Mellitus: A Meta-Analysis and Systematic Review of Randomized Clinical Trials.

Science.gov (United States)

Gu, Yuming; Xu, Xuemin; Wang, Zhe; Xu, Yunsheng; Liu, Xiuzhi; Cao, Lejun; Wang, Xueyang; Li, Zhengxin; Feng, Bo

2018-01-01

Chromium-containing traditional Chinese medicine Tianmai Xiaoke tablet (TMXKT) is approved for treating newly diagnosed type 2 diabetes mellitus (T2DM) in China. This review aimed to compile the evidence from randomized clinical trials (RCTs) and quantify the effects of TMXKT on newly diagnosed T2DM. Seven online databases were investigated up to March 20, 2017. The meta-analysis included RCTs investigating the treatment of newly diagnosed T2DM, in which TMXKT combined with conventional therapy was compared with placebo or conventional therapy. The risk of bias was evaluated using the Cochrane Collaboration tool. The estimated mean difference (MD) and the standardized mean difference were within 95% confidence intervals (CI) with respect to the interstudy heterogeneity. The outcomes were measured using fasting blood glucose (FBG), 2-h postprandial blood glucose (2hPG), glycosylated hemoglobin A1c (HbA1c), and body mass index (BMI) levels. TMXKT combined with conventional therapy lowered FBG level (MD = -0.68, 95% CI -0.90 to -0.45, P < 0.00001), 2hPG (MD = -1.33, 95% CI -1.86 to -0.79, P < 0.00001), HbA1c (MD = -0.46, 95% CI -0.57 to -0.36, P < 0.00001), and BMI (MD = -0.77, 95% CI -1.12 to -0.41, P < 0.00001). TMXKT combined with conventional therapy is beneficial for patients with newly diagnosed T2DM. However, the effectiveness and safety of TMXKT are uncertain because of the limited number of trials and low methodological quality. Therefore, practitioners should be cautious when applying TMXKT in daily practice. Also, well-designed clinical trials are needed in the future.

Newly Generated Liquid Waste Processing Alternatives Study, Volume 1

Energy Technology Data Exchange (ETDEWEB)

Landman, William Henry; Bates, Steven Odum; Bonnema, Bruce Edward; Palmer, Stanley Leland; Podgorney, Anna Kristine; Walsh, Stephanie

2002-09-01

This report identifies and evaluates three options for treating newly generated liquid waste at the Idaho Nuclear Technology and Engineering Center of the Idaho National Engineering and Environmental Laboratory. The three options are: (a) treat the waste using processing facilities designed for treating sodium-bearing waste, (b) treat the waste using subcontractor-supplied mobile systems, or (c) treat the waste using a special facility designed and constructed for that purpose. In studying these options, engineers concluded that the best approach is to store the newly generated liquid waste until a sodium-bearing waste treatment facility is available and then to co-process the stored inventory of the newly generated waste with the sodium-bearing waste. After the sodium-bearing waste facility completes its mission, two paths are available. The newly generated liquid waste could be treated using the subcontractor-supplied system or the sodium-bearing waste facility or a portion of it. The final decision depends on the design of the sodium-bearing waste treatment facility, which will be completed in coming years.

Blade design and performance analysis on the horizontal axis tidal current turbine for low water level channel

International Nuclear Information System (INIS)

Chen, C C; Choi, Y D; Yoon, H Y

2013-01-01

Most tidal current turbine design are focused on middle and large scale for deep sea, less attention was paid in low water level channel, such as the region around the islands, coastal seas and rivers. This study aims to develop a horizontal axis tidal current turbine rotor blade which is applicable to low water level island region in southwest of Korea. The blade design is made by using BEMT(blade element momentum theory). The section airfoil profile of NACA63-415 is used, which shows good performance of lift coefficient and drag coefficient. Power coefficient, pressure and velocity distributions are investigated according to TSR by CFD analysis

Removal of toxic Cr(VI) ions from tannery industrial wastewater using a newly designed three-phase three-dimensional electrode reactor

Science.gov (United States)

Grace Pavithra, K.; Senthil Kumar, P.; Carolin Christopher, Femina; Saravanan, A.

2017-11-01

In this research, the wastewater samples were collected from leather tanning industry at different time intervals. The parameters like pH, electrical conductivity, temperature, turbidity, chromium and chemical oxygen demand (COD) of the samples were analyzed. A three-phase three-dimensional fluidized type electrode reactor (FTER) was newly designed for the effective removal of toxic pollutants from wastewater. The influencing parameters were optimized for the maximum removal of toxic pollutants from wastewater. The optimum condition for the present system was calculated as: contact time of 30 min, applied voltage of 3 V and the particle electrodes of 15 g. The particle electrode was characterized by using FT-IR analysis. Langmuir-Hinshelwood and pseudo-second order kinetic models were fits well with the experimental data. The results showed that the FTER can be successfully employed for the treatment of industrial wastewater.

The Winfrith horizontal impact rig

International Nuclear Information System (INIS)

Barr, P.

1985-12-01

The Horizontal Impact Rig has been designed to allow studies of the impact of radioactive material transport containers and their associated transport vehicles and impact limiters, using large scale models, and to allow physically large missiles to be projected for studying the impact behaviour of metal and concrete structures. It provides an adequately rigid support structure for impact experiments with targets of large dimensions. Details of its design, instrumentation, performance prediction and construction are given. (U.K.)

Surgical Success Rates for Horizontal Concomitant Deviations According to the Type and Degree of Deviation

Directory of Open Access Journals (Sweden)

İhsan Çaça

2004-01-01

Full Text Available We evaluated the correlation with success rates and deviation type and degree inhorizontal concomitant deviations. 104 horizontal concomitan strabismus cases whowere operated in our clinic between January 1994 – December 2000 were included in thestudy. 56 cases undergone recession-resection procedure in the same eye 19 cases twomuscle recession and one muscle resection, 20 cases two muscle recession, 9 cases onlyone muscle recession. 10 ± prism diopter deviation in postoperative sixth monthexamination was accepted as surgical success.Surgical success rate was 90% and 89.3% in the cases with deviation angle of 15-30and 31-50 prism diopter respectively. Success rate was 78.9% if the angle was more than50 prism diopter. According to strabismus type when surgical success rate examined; inalternan esotropia 88.33%, in alternan exotropia 84.6%, in monocular esotropia 88%and in monocular exotropia 83.3% success was fixed. Statistically significant differencewas not found between strabismus type and surgical success rate. The binocular visiongaining rate was found as 51.8% after the treatment of cases.In strabismus surgery, preoperative deviation angle was found to be an effectivefactor on the success rate.

Increasing energy efficiency by geometric modification of hoe-type furrow opener

Directory of Open Access Journals (Sweden)

R Rahimzadeh

2016-09-01

Full Text Available Introduction Direct planting becomes more common in the recent years, because it conserves soil and water as well as it saves energy and time. However, this technology needs special implements such as seed planter. Given that direct planting is practiced in undisturbed lands, so it was needed to design a special furrow opener. In order to obtain a suitable furrow opener this experiment was conducted in rain-fed Agricultural Research Institute in Maragheh. Materials and Methods Most of seed planters that are used for cultivation in rain fed conditions are equipped by hoe-type furrow opener. Hoe-type furrow openers have good penetration in hard and dry soils. However, they do not have the ability for direct planting. Hoe-type furrow opener was chosen as a model. Then by changing the geometric form of the depth to width ratio (d/w, the two openers were designed. In the first design, which was called O1 two wings and a narrow blade acting as a coulter were added in front of the hoe-type furrow opener. In the second design, which was called O2, in addition to the O1 modification, furrow opener width was decreased and a disk blade was added for seed sowing (Fig. 1. The performance of O1 and O2 openers were compared with the conventional hoe-type furrow opener (check in soil bin and in field conditions. At three different forward speeds (1, 1.5 and 2 m.s-1 with 3 replications, the effects of the openers designs of vertical and horizontal soil forces were evaluated in soil-bin conditions. In order to evaluate the performance of the furrow opener in field conditions, an experiment was conducted using a split plot design based on RCBD at 4 replications. Furrow openers formed the main plots and forward speeds formed the sub plots. Each plot size was 22 meters long in two rows for each treatment. After germination of wheat crop, the numbers of seedlings in two rows were counted (along a one meter. After crop maturity, all plots were harvested by hand and

Relationship between ZnT8Ab, the SLC30A8 gene and disease progression in children with newly diagnosed type 1 diabetes

DEFF Research Database (Denmark)

Nielsen, Lotte B; Vaziri-Sani, Fariba; Pörksen, Sven

2011-01-01

Autoantibodies against the newly established autoantigen in type 1 diabetes, zinc transporter 8, ZnT8, are presented as two types, ZnT8RAb and ZnT8WAb. The rs13266634 variant of the SLC30A8 gene has recently been found to determine the type of ZnT8Ab. The aim of this study was to explore the impact...

Prevalence of Chronic Diabetic Complications in Newly Diagnosed versus Known Type 2 Diabetic Subjects in a Sample of Alexandria Population, Egypt.

Science.gov (United States)

Khalil, Samir Assaad; Megallaa, Magdy Helmy; Rohoma, Kamel Hemida; Guindy, Myriam AbouSeif; Zaki, Adel; Hassanein, Mohamed; Malaty, Amin Helmy; Ismael, Hanaa Mohamed; Kharboush, Ibrahim Fahmy; El Kafash, Dalal Nasr-Eldein; Sallam, Hassan Nooman; Desouky, Iman Abdelkareem

2018-01-24

In Egypt, data on the prevalence of chronic diabetic complications, which are essential for the adjustment of policies and practices related to diabetes care, are scarce. Therefore, the aim of this study was to determine the frequency of chronic complications of diabetes; namely neuropathy, diabetic kidney disease (DKD), retinopathy and peripheral arterial disease (PAD) in newly-diagnosed versus known type 2 diabetic patients. This is a cross-sectional study that is based on a previous household survey conducted on a representative sample of the population of Alexandria, Egypt. This study included 506 consecutive subjects with type 2 diabetes; 323 patients with previously known T2DM and 183 patients with newly diagnosed T2DM (discovered during the survey). For each participant, a focused history was taken. Comprehensive clinical examination was done including fundus examination, foot examination and assessment of ankle brachial index. Laboratory tests included HbAlc, lipids profile, serum creatinine and urinary albumin creatinine ratio (UACR). Peripheral neuropathy was detected in 20% of the studied patients; 29.4% of known patients and 3.3% of newly diagnosed patients (pDiabetic kidney disease was detected in 33.2% of the studied patients; 46.1% of known patients and 10.4% of newly diagnosed patients (pDiabetic retinopathy was detected in 34.6% of the studied patients; 48.3% of known patients and 10.4% of newly diagnosed patients (pdiabetes, the presence of any of the studied complications (neuropathy, diabetic kidney disease, retinopathy or PAD) was significantly associated with the presence of all other complications (pdiabetes, the presence of diabetic kidney disease was significantly associated with the presence of retinopathy (pdiabetes at the time of diagnosis. Finally, these results should be considered as a call for action for the health care planners and providers in our region to plan for early screening for diabetes and its complications to reduce the

Improving horizontal completions on heterogeneous tight shales

Energy Technology Data Exchange (ETDEWEB)

Suarez-Rivera, Roberto; Deenadayalu, Chaitanya; Chertov, Maxim; Novalo Hartanto, Ricardo; Gathogo, Patrick [Schlumberger (United States); Kunjir, Rahul [University of Utah (United States)

2011-07-01

Evaluation of the two formation characteristics conducive to economic well production is important when tight shale formation characterization and completion design are being considered. This paper presents the basic understanding required to improve the efficiency of horizontal completions in oil and gas producing shales. Guidelines are defined for effective perforation and fracturing to improve the efficiency and sustainability of horizontal completions using extensive laboratory characterization of mechanical properties on core, core/log integration and continuous mapping of these properties by logging-while-drilling (LWD) methods. The objective is to improve completion design efficiency. This is accomplished by suitable selection of perforation intervals based on an understanding of the relevant physical processes and rock characterization. Conditions at two reservoir regions, the near-wellbore and the far-wellbore, are outlined and are essential to completion design. From the study, it can be concluded that tight shales are strongly anisotropic and cannot be approximated using isotropic models.

A horizontal vane radiometer: experiment, theory and simulation

OpenAIRE

Wolfe, David; Lazarra, Andres; Garcia, Alejandro

2015-01-01

The existence of two motive forces on a Crookes radiometer has complicated the investigation of either force independently. The thermal creep shear force in particular has been subject to differing interpretations of the direction in which it acts and its order of magnitude. In this article we provide a horizontal vane radiometer design which isolates the thermal creep shear force. The horizontal vane radiometer is explored through experiment, kinetic theory, and the Direct Simulation Monte C...

Evaluating the Physiological and Perceptual Responses of Wearing a Newly Designed Cooling Vest for Construction Workers.

Science.gov (United States)

Zhao, Yijie; Yi, Wen; Chan, Albert P C; Wong, Francis K W; Yam, Michael C H

2017-08-01

Construction workers are subjected to heat stress because of the hot environment, physically demanding tasks, and/or personal protective equipment. A tailor-made cooling vest that protects construction workers from heat-related injuries was developed. The purpose of the study is to examine a newly designed cooling vest's effectiveness in alleviating physiological and perceptual strain in a hot and humid environment. Twelve male participants performed two trials, i.e., cooling vest (VEST) and control (CON) in a climatic chamber controlled at 37°C temperature, 60% relative humidity, 0.3 m/s air velocity, and 450 W/m2 solar radiation to simulate the summer working environment of construction sites. Two bouts of treadmill exercise intermitted with 30-minute passive recovery were designed to simulate the practical work-rest schedule of the construction industry. The cooling vest was used during the passive recovery period in the VEST condition, and the results were compared with that of no cooling vest in the CON condition. The results revealed that the newly designed cooling vest can significantly alleviate heat strain and improve thermal comfort, based on the decrease in body temperature, heart rate, and subjective perceptions (including perceived exertion, thermal, wetness, and comfort sensation) of the participants. It can also prolong work duration in the subsequent exercise. The cooling countermeasures proposed in this study will be able to provide an effective solution in situations that involve repeated bouts of outdoor construction work. © The Author 2017. Published by Oxford University Press on behalf of the British Occupational Hygiene Society.

Biomedical, lifestyle and psychosocial characteristics of people newly diagnosed with type 2 diabetes

DEFF Research Database (Denmark)

Khunti, K.; Skinner, T. C.; Heller, S.

2008-01-01

Aims: To describe the characteristics of newly diagnosed people with Type 2 diabetes (T2DM) and compare these with published studies. Methods: Baseline data of participants recruited to the DESMOND randomized controlled trial conducted in 13 sites across England and Scotland were used. Biomedical...... measures and questionnaires on psychological characteristics were collected within 4 weeks of diagnosis. Results: Of 1109 participants referred, 824 consented to participate (74.3%). Mean (± sd) age was 59.5 ± 12 years and 54.9% were male. Mean HbA1c was 8.1 ± 2.1% and did not differ by gender. Mean body...... mass index (BMI) was significantly higher in women (33.7 vs. 31.3 kg/m2; P 30 kg/m2). Total cholesterol was significantly higher in women (5.6 vs. 5.2 mmol/l; P

A newly-recognized galactic supernova remnant with shell-type and filled-center features

International Nuclear Information System (INIS)

Barnes, D.J.; Turtle, A.J.

1988-01-01

While the number of galactic supernova remnants (SNRs) now known is fairly large (>150), the subset among these that are known to resemble the Crab Nebula is still distressingly small, about 15 or so. Thus any object that can be unambiguously included in this exclusive club forms a valuable addition to knowledge of this class. The authors report observations of a newly recognized nonthermal galactic object, G18.94-1.06, having all the hallmarks of the classical shell-type SNRs, while also appearing to have a filled-centre component located inside the shell. Among the known Crab-like remnants, about one third show this dual nature. This diagnosis of G18.94-1.06 is supported mainly by the variations in spectral index across the source, as seen between the two observation frequencies, 408 MHz and 5.0 GHz

Exact Solutions of a High-Order Nonlinear Wave Equation of Korteweg-de Vries Type under Newly Solvable Conditions

Directory of Open Access Journals (Sweden)

Weiguo Rui

2014-01-01

Full Text Available By using the integral bifurcation method together with factoring technique, we study a water wave model, a high-order nonlinear wave equation of KdV type under some newly solvable conditions. Based on our previous research works, some exact traveling wave solutions such as broken-soliton solutions, periodic wave solutions of blow-up type, smooth solitary wave solutions, and nonsmooth peakon solutions within more extensive parameter ranges are obtained. In particular, a series of smooth solitary wave solutions and nonsmooth peakon solutions are obtained. In order to show the properties of these exact solutions visually, we plot the graphs of some representative traveling wave solutions.

Computational fluid dynamics (CFD) simulation of a newly designed passive particle sampler.

Science.gov (United States)

Sajjadi, H; Tavakoli, B; Ahmadi, G; Dhaniyala, S; Harner, T; Holsen, T M

2016-07-01

In this work a series of computational fluid dynamics (CFD) simulations were performed to predict the deposition of particles on a newly designed passive dry deposition (Pas-DD) sampler. The sampler uses a parallel plate design and a conventional polyurethane foam (PUF) disk as the deposition surface. The deposition of particles with sizes between 0.5 and 10 μm was investigated for two different geometries of the Pas-DD sampler for different wind speeds and various angles of attack. To evaluate the mean flow field, the k-ɛ turbulence model was used and turbulent fluctuating velocities were generated using the discrete random walk (DRW) model. The CFD software ANSYS-FLUENT was used for performing the numerical simulations. It was found that the deposition velocity increased with particle size or wind speed. The modeled deposition velocities were in general agreement with the experimental measurements and they increased when flow entered the sampler with a non-zero angle of attack. The particle-size dependent deposition velocity was also dependent on the geometry of the leading edge of the sampler; deposition velocities were more dependent on particle size and wind speeds for the sampler without the bend in the leading edge of the deposition plate, compared to a flat plate design. Foam roughness was also found to have a small impact on particle deposition. Copyright © 2016 Elsevier Ltd. All rights reserved.

Design of novel SOI 1 × 4 optical power splitter using seven horizontally slotted waveguides

Science.gov (United States)

Katz, Oded; Malka, Dror

2017-07-01

In this paper, we demonstrate a compact silicon on insulator (SOI) 1 × 4 optical power splitter using seven horizontal slotted waveguides. Aluminum nitride (AIN) surrounded by silicon (Si) was used to confine the optical field in the slot region. All of the power analysis has been done in transverse magnetic (TM) polarization mode and a compact optical power splitter as short as 14.5 μm was demonstrated. The splitter was designed by using full vectorial beam propagation method (FV-BPM) simulations. Numerical investigations show that this device can work across the whole C-band (1530-1565 nm) with excess loss better than 0.23 dB.

Characteristics of a newly designed electrolyser to enrich tritium in environmental water

International Nuclear Information System (INIS)

Shima, Nagayoshi; Muranaka, Takeshi

2007-01-01

A newly designed electrolytic device to enrich tritium in environmental water is proposed. This device is composed of a solid polymer electrolytic film (SPE film) and porous, dimensionally stable electrodes (DSE). In our design a platinum mesh was inserted between the SPE film and the anode DSE so that the device can be easily disassembled and the used SPE film can be replaced with a new one after each use. A thin gold plate with a number of minute holes in it is used as current collector in both electrodes allowing the electrolytic gas to be released progressively. An electrolytic current of 6A was passed through the device to obtain a volume reducing factor of five by keeping a temperature of water both at 2degC or lower. After that, our device achieved a tritium recovery factor of 0.836±0.021 (n=4). Such a value is greater than the value obtained using a commercially available apparatus operated under the same experimental conditions. It is thought that this greater efficiency depends on the difference between electrolytic temperature produced in our device and the temperature in the commercially available one. (author)

Single feedback systems for simultaneous damping of horizontal and longitudinal coherent oscillations

International Nuclear Information System (INIS)

Chao, A.W.; Morton, P.L.; Rees, J.R.

1979-03-01

To describe the horizontal motion of the bunch, we need four coordinates, x and z are the horizontal and longitudinal displacements of the bunch center relative to the ideal trajectory; x' is the angle between the bunch's direction of motion and the ideal trajectory; and δ=ΔE/E is relative energy error of the bunch. Among the four variables, x and z are easy to measure by position monitors, while x' and δ are easy to change by electromagnetic devices. In combination, this suggests four possible types of feedback systems. In the following, we will present a complete analysis of the Type (x, δ) feedback system, using a matrix method. The analyses of other types are similar to that of Type (x, δ) and only the results are included. We then include some comparisons of these types of feedback schemes in terms of power consumptions and the effectiveness in damping the horizontal-betatron and synchrotron oscillations. We will also discuss some effects of position measuring errors on the performance of the feedback system. 2 refs., 3 tabs

A method for evaluating horizontal well pumping tests.

Science.gov (United States)

Langseth, David E; Smyth, Andrew H; May, James

2004-01-01

Predicting the future performance of horizontal wells under varying pumping conditions requires estimates of basic aquifer parameters, notably transmissivity and storativity. For vertical wells, there are well-established methods for estimating these parameters, typically based on either the recovery from induced head changes in a well or from the head response in observation wells to pumping in a test well. Comparable aquifer parameter estimation methods for horizontal wells have not been presented in the ground water literature. Formation parameter estimation methods based on measurements of pressure in horizontal wells have been presented in the petroleum industry literature, but these methods have limited applicability for ground water evaluation and are based on pressure measurements in only the horizontal well borehole, rather than in observation wells. This paper presents a simple and versatile method by which pumping test procedures developed for vertical wells can be applied to horizontal well pumping tests. The method presented here uses the principle of superposition to represent the horizontal well as a series of partially penetrating vertical wells. This concept is used to estimate a distance from an observation well at which a vertical well that has the same total pumping rate as the horizontal well will produce the same drawdown as the horizontal well. This equivalent distance may then be associated with an observation well for use in pumping test algorithms and type curves developed for vertical wells. The method is shown to produce good results for confined aquifers and unconfined aquifers in the absence of delayed yield response. For unconfined aquifers, the presence of delayed yield response increases the method error.

Horizontal well geosteering: planning, monitoring and geosteering

Energy Technology Data Exchange (ETDEWEB)

Mottahedeh, R.

2008-11-15

The geosteering process should not be seen as a process solely designated for the most expensive or highest profile horizontal wells. It can be regarded as another tool for improving the odds of success by remaining in the productive zone for longer periods of drilling. Also, it can be used to optimize the positioning of a horizontal wellbore in the sweet spots within the reservoir. The current process has been successfully applied to large infill drilling programs at over 40 wells for heavy oil, tight gas, conventional oil and gas plays and for Mannville coalbed methane (CBM) in Alberta. The service has been provided irrespective of location, as long as the Wellsite Information Transfer Standard Markup Language (WITSML)/Pason Satellite service is available. Exploration and production (E&P) companies are continuously being driven to reduce the cost per barrel of oil equivalent (BOE). E&P needs and technologies related to advanced and accurate directional drilling, communication of vital data in real-time through the internet, as well as reduced cycle time associated with advanced forward-looking 3D geo-modelling and visualization technologies, are currently converging. The motivation to reduce costs has been responsible for advancing the horizontal well geosteering process by incorporating the Measurement While Drilling (MWD) tool into mainstream drilling practices. The universal economic benefits gained can be found in all resource play types (conventional oil and gas, heavy oil, tight gas and coalbed methane). It is important to note that the process described here is essentially collaborative. For best results, there must be cooperation between the E&P operational geologist, wellsite geologist, directional driller and geo-modelling staff, as well as the engineering consultants involved in the project (i.e. the team as a whole).

Electroluminescence from completely horizontally oriented dye molecules

Energy Technology Data Exchange (ETDEWEB)

Komino, Takeshi [Education Center for Global Leaders in Molecular System for Devices, Kyushu University, 744 Motooka, Nishi, Fukuoka 819-0395 (Japan); Center for Organic Photonics and Electronics Research, Kyushu University, 744 Motooka, Nishi, Fukuoka 819-0395 (Japan); Japan Science and Technology Agency, ERATO, Adachi Molecular Exciton Engineering Project, 744 Motooka, Nishi, Fukuoka 819-0395 (Japan); Sagara, Yuta [Center for Organic Photonics and Electronics Research, Kyushu University, 744 Motooka, Nishi, Fukuoka 819-0395 (Japan); Tanaka, Hiroyuki [Center for Organic Photonics and Electronics Research, Kyushu University, 744 Motooka, Nishi, Fukuoka 819-0395 (Japan); Department of Chemistry, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601 (Japan); Oki, Yuji [Japan Science and Technology Agency, ERATO, Adachi Molecular Exciton Engineering Project, 744 Motooka, Nishi, Fukuoka 819-0395 (Japan); Department of Electronics, Kyushu University, 744 Motooka, Nishi, Fukuoka 819-0395 (Japan); Nakamura, Nozomi [Center for Organic Photonics and Electronics Research, Kyushu University, 744 Motooka, Nishi, Fukuoka 819-0395 (Japan); International Institute for Carbon Neutral Energy Research (WPI-I2CNER), Kyushu University, 744 Motooka, Nishi, Fukuoka 819-0395 (Japan); Fujimoto, Hiroshi [Center for Organic Photonics and Electronics Research, Kyushu University, 744 Motooka, Nishi, Fukuoka 819-0395 (Japan); Fukuoka i" 3-Center for Organic Photonics and Electronics Research (i3-OPERA), Fukuoka 819-0388 (Japan); and others

2016-06-13

A complete horizontal molecular orientation of a linear-shaped thermally activated delayed fluorescent guest emitter 2,6-bis(4-(10Hphenoxazin-10-yl)phenyl)benzo[1,2-d:5,4-d′] bis(oxazole) (cis-BOX2) was obtained in a glassy host matrix by vapor deposition. The orientational order of cis-BOX2 depended on the combination of deposition temperature and the type of host matrix. Complete horizontal orientation was obtained when a thin film with cis-BOX2 doped in a 4,4′-bis(N-carbazolyl)-1,1′-biphenyl (CBP) host matrix was fabricated at 200 K. The ultimate orientation of guest molecules originates from not only the kinetic relaxation but also the kinetic stability of the deposited guest molecules on the film surface during film growth. Utilizing the ultimate orientation, a highly efficient organic light-emitting diode with the external quantum efficiency of 33.4 ± 2.0% was realized. The thermal stability of the horizontal orientation of cis-BOX2 was governed by the glass transition temperature (T{sub g}) of the CBP host matrix; the horizontal orientation was stable unless the film was annealed above T{sub g}.

Horizontal and Vertical Rule Bases Method in Fuzzy Controllers

Directory of Open Access Journals (Sweden)

Sadegh Aminifar

2013-01-01

Full Text Available Concept of horizontal and vertical rule bases is introduced. Using this method enables the designers to look for main behaviors of system and describes them with greater approximations. The rules which describe the system in first stage are called horizontal rule base. In the second stage, the designer modulates the obtained surface by describing needed changes on first surface for handling real behaviors of system. The rules used in the second stage are called vertical rule base. Horizontal and vertical rule bases method has a great roll in easing of extracting the optimum control surface by using too lesser rules than traditional fuzzy systems. This research involves with control of a system with high nonlinearity and in difficulty to model it with classical methods. As a case study for testing proposed method in real condition, the designed controller is applied to steaming room with uncertain data and variable parameters. A comparison between PID and traditional fuzzy counterpart and our proposed system shows that our proposed system outperforms PID and traditional fuzzy systems in point of view of number of valve switching and better surface following. The evaluations have done both with model simulation and DSP implementation.

Clinical characteristics and beta cell function in Chinese patients with newly diagnosed type 2 diabetes mellitus with different levels of serum triglyceride.

Science.gov (United States)

Zheng, Shuang; Zhou, Huan; Han, Tingting; Li, Yangxue; Zhang, Yao; Liu, Wei; Hu, Yaomin

2015-04-29

To explore clinical characteristics and beta cell function in Chinese patients with newly diagnosed drug naive type 2 diabetes mellitus (T2DM) with different levels of serum triglyceride (TG). Patients with newly diagnosed T2DM (n = 624) were enrolled and divided into different groups according to levels of serum TG. All patients underwent oral glucose tolerance tests and insulin releasing tests. Demographic data, lipid profiles, glucose levels, and insulin profiles were compared between different groups. Basic insulin secretion function index (homeostasis model assessment for beta cell function index, HOMA-β), modified beta cell function index (MBCI), glucose disposition indices (DI), and early insulin secretion function index (insulinogenic index, IGI) were used to evaluate the beta cell function. Patients of newly diagnosed T2DM with hypertriglyceridemia were younger, fatter and had worse lipid profiles, glucose profiles, and high insulin levels than those with normal TG. There is no difference in early phase insulin secretion among groups of newly diagnosed T2DM patients with different TG levels. The basal beta cell function (HOMA-β and MBCI) initially increased along rising TG levels and then decreased as the TG levels rose further. The insulin sensitivity was relatively high in patients with a low level of TG and low with a high level of TG. Hypertriglyceridemia influences clinical characteristics and β cell function of Chinese patients with newly diagnosed T2DM. A better management of dyslipidemia may, to some extent, reduce the effect of lipotoxicity, thereby improving glucose homeostasis in patients with newly diagnosed T2DM.

Horizontal Stratification in Access to Danish University Programmes

DEFF Research Database (Denmark)

Munk, Martin D.; Thomsen, Jens Peter

2018-01-01

a relatively detailed classification of parents’ occupations to determine how students are endowed with different forms of capital, even when their parents would typically be characterised as belonging to the same social group. Second, we distinguish among disciplines and among university institutions...... to explain the dynamics of horizontal stratification in the Danish university system. Using unique and exhaustive register data, including all higher education institutions and the entire 1984 cohort as of the age of 24, we uncover distinct differences in the magnitude and type of horizontal stratification...... in different fields of study and university institutions. Most importantly, we find distinct patterns of horizontal stratification by field of study and parental occupation that would have remained hidden had we used more aggregated classifications for field of study and social origin....

Groundwater flow to a horizontal or slanted well in an unconfined aquifer

Science.gov (United States)

Zhan, Hongbin; Zlotnik, Vitaly A.

2002-07-01

New semianalytical solutions for evaluation of the drawdown near horizontal and slanted wells with finite length screens in unconfined aquifers are presented. These fully three-dimensional solutions consider instantaneous drainage or delayed yield and aquifer anisotropy. As a basis, solution for the drawdown created by a point source in a uniform anisotropic unconfined aquifer is derived in Laplace domain. Using superposition, the point source solution is extended to the cases of the horizontal and slanted wells. The previous solutions for vertical wells can be described as a special case of the new solutions. Numerical Laplace inversion allows effective evaluation of the drawdown in real time. Examples illustrate the effects of well geometry and the aquifer parameters on drawdown. Results can be used to generate type curves from observations in piezometers and partially or fully penetrating observation wells. The proposed solutions and software are useful for the parameter identification, design of remediation systems, drainage, and mine dewatering.

Fourth international seminar on horizontal steam generators

Energy Technology Data Exchange (ETDEWEB)

Tuomisto, H. [ed.] [IVO Group, Vantaa (Finland); Purhonen, H. [ed.] [VTT, Espoo (Finland); Kouhia, V. [ed.] [Lappeenranta Univ. of Technology (Finland)

1997-12-31

The general objective of the International Seminars of Horizontal Steam Generator Modelling has been the improvement in understanding of realistic thermal hydraulic behaviour of the generators when performing safety analyses for VVER reactors. The main topics presented in the fourth seminar were: thermal hydraulic experiments and analyses, primary collector integrity, feedwater distributor replacement, management of primary-to-secondary leakage accidents and new developments in the VVER safety technology. The number of participants, representing designers and manufacturers of the horizontal steam generators, plant operators, engineering companies, research organizations, universities and regulatory authorities, was 70 from 10 countries.

Fourth international seminar on horizontal steam generators

Energy Technology Data Exchange (ETDEWEB)

Tuomisto, H [ed.; IVO Group, Vantaa (Finland); Purhonen, H [ed.; VTT, Espoo (Finland); Kouhia, V [ed.; Lappeenranta Univ. of Technology (Finland)

1998-12-31

The general objective of the International Seminars of Horizontal Steam Generator Modelling has been the improvement in understanding of realistic thermal hydraulic behaviour of the generators when performing safety analyses for VVER reactors. The main topics presented in the fourth seminar were: thermal hydraulic experiments and analyses, primary collector integrity, feedwater distributor replacement, management of primary-to-secondary leakage accidents and new developments in the VVER safety technology. The number of participants, representing designers and manufacturers of the horizontal steam generators, plant operators, engineering companies, research organizations, universities and regulatory authorities, was 70 from 10 countries.

Fourth international seminar on horizontal steam generators

International Nuclear Information System (INIS)

Tuomisto, H.; Purhonen, H.; Kouhia, V.

1997-01-01

The general objective of the International Seminars of Horizontal Steam Generator Modelling has been the improvement in understanding of realistic thermal hydraulic behaviour of the generators when performing safety analyses for VVER reactors. The main topics presented in the fourth seminar were: thermal hydraulic experiments and analyses, primary collector integrity, feedwater distributor replacement, management of primary-to-secondary leakage accidents and new developments in the VVER safety technology. The number of participants, representing designers and manufacturers of the horizontal steam generators, plant operators, engineering companies, research organizations, universities and regulatory authorities, was 70 from 10 countries

Condensation Analysis of Steam/Air Mixtures in Horizontal Tubes

International Nuclear Information System (INIS)

Lee, Kwon Yeong; Bae, Sung Won; Kim, Moo Hwan

2008-01-01

Perhaps the most common flow configuration in which a convective condensation occurs is a flow in a horizontal circular tube. This configuration is encountered in air-conditioning and refrigeration condensers as well as condensers in Rankine power cycles. Although a convective condensation is also sometimes contrived to occur in a co-current vertical downward flow, a horizontal flow is often preferred because the flow can be repeatedly passed through the heat exchanger core in a serpentine fashion without trapping liquid or vapor in the return bends. Many researchers have investigated a in-tube condensation for horizontal heat exchangers. However, almost all of them obtained tube section-averaged data without a noncondensable gas. Recently, Wu and Vierow have experimentally studied the condensation of steam in a horizontal heat exchanger with air present. In order to measure the condenser tube inner surface temperatures and to calculate the local heat fluxes, they developed an innovative thermocouple design that allowed for nonintrusive measurements. Here we developed a theoretical model using the heat and mass analogy to analyze a steam condensation with a noncondensable gas in horizontal tubes

Horizontal ground coupled heat pump: Thermal-economic modeling and optimization

Energy Technology Data Exchange (ETDEWEB)

Sanaye, Sepehr; Niroomand, Behzad [Energy Systems Improvement Laboratory (ESIL), Department of Mechanical Engineering, Iran University of Science and Technology (IUST) (Iran)

2010-12-15

The modeling and optimizing processes of a Ground Coupled Heat Pump (GCHP) with closed Horizontal Ground Heat eXchanger (HGHX) are presented in this paper. After thermal modeling of GCHP including HGHX, the optimum design parameters of the system were estimated by minimizing a defined objective function (total of investment and operation costs) subject to a list of constraints. This procedure was performed applying Genetic Algorithm technique. For given heating/cooling loads and various climatic conditions, the optimum values of saturated temperature/pressure of condenser and evaporator as well as inlet and outlet temperatures of the water source in cooling and heating modes were predicted. Then, for our case study, the design parameters as well as the configuration of HGHX were obtained. Furthermore, the sensitivity analysis of change in the total annual cost of the system and optimum design parameters with the climatic conditions, cooling/heating capacity, and soil type were discussed. (author)

Horizontal ground coupled heat pump: Thermal-economic modeling and optimization

International Nuclear Information System (INIS)

Sanaye, Sepehr; Niroomand, Behzad

2010-01-01

The modeling and optimizing processes of a Ground Coupled Heat Pump (GCHP) with closed Horizontal Ground Heat eXchanger (HGHX) are presented in this paper. After thermal modeling of GCHP including HGHX, the optimum design parameters of the system were estimated by minimizing a defined objective function (total of investment and operation costs) subject to a list of constraints. This procedure was performed applying Genetic Algorithm technique. For given heating/cooling loads and various climatic conditions, the optimum values of saturated temperature/pressure of condenser and evaporator as well as inlet and outlet temperatures of the water source in cooling and heating modes were predicted. Then, for our case study, the design parameters as well as the configuration of HGHX were obtained. Furthermore, the sensitivity analysis of change in the total annual cost of the system and optimum design parameters with the climatic conditions, cooling/heating capacity, and soil type were discussed.

Space shuttle orbiter guidance, naviagation and control software functional requirements: Horizontal flight operations

Science.gov (United States)

1972-01-01

The shuttle GN&C software functions for horizontal flight operations are defined. Software functional requirements are grouped into two categories: first horizontal flight requirements and full mission horizontal flight requirements. The document privides the intial step in the shuttle GN&C software design process. It also serves as a management tool to identify analyses which are required to define requirements.

An optimal design of cluster spacing intervals for staged fracturing in horizontal shale gas wells based on the optimal SRVs

Directory of Open Access Journals (Sweden)

Lan Ren

2017-09-01

Full Text Available When horizontal well staged cluster fracturing is applied in shale gas reservoirs, the cluster spacing is essential to fracturing performance. If the cluster spacing is too small, the stimulated area between major fractures will be overlapped, and the efficiency of fracturing stimulation will be decreased. If the cluster spacing is too large, the area between major fractures cannot be stimulated completely and reservoir recovery extent will be adversely impacted. At present, cluster spacing design is mainly based on the static model with the potential reservoir stimulation area as the target, and there is no cluster spacing design method in accordance with the actual fracturing process and targets dynamic stimulated reservoir volume (SRV. In this paper, a dynamic SRV calculation model for cluster fracture propagation was established by analyzing the coupling mechanisms among fracture propagation, fracturing fluid loss and stress. Then, the cluster spacing was optimized to reach the target of the optimal SRVs. This model was applied for validation on site in the Jiaoshiba shale gasfield in the Fuling area of the Sichuan Basin. The key geological engineering parameters influencing the optimal cluster spacing intervals were analyzed. The reference charts for the optimal cluster spacing design were prepared based on the geological characteristics of south and north blocks in the Jiaoshiba shale gasfield. It is concluded that the cluster spacing optimal design method proposed in this paper is of great significance in overcoming the blindness in current cluster perforation design and guiding the optimal design of volume fracturing in shale gas reservoirs. Keywords: Shale gas, Horizontal well, Staged fracturing, Cluster spacing, Reservoir, Stimulated reservoir volume (SRV, Mathematical model, Optimal method, Sichuan basin, Jiaoshiba shale gasfield

Exploration of horizontal intrinsic spin resonances with two partial Siberian snakes

Directory of Open Access Journals (Sweden)

F. Lin

2007-04-01

Full Text Available Two partial Siberian snakes were used to avoid all the spin imperfection and vertical intrinsic resonances in the alternating gradient synchrotron (AGS at Brookhaven National Laboratory. However, the horizontal betatron motion can cause polarization loss resulting from the nonvertical stable spin direction in the presence of two partial snakes. This type of resonance, called a horizontal intrinsic spin resonance, was observed and systematically studied in the AGS. A simplified analytic model and numerical simulation have been developed to compare with experimental data. Properties of the horizontal intrinsic resonance are discussed.

A new accelerator tube and column for a horizontal 8 MV tandem

International Nuclear Information System (INIS)

Sundquist, M.L.; Rathmell, R.D.; Raatz, J.E.

1990-01-01

A horizontal 8 MV tandem is being installed in an existing tank at Kyoto University in Japan. This NEC Model 8UDH is the largest horizontal Pelletron constructed to date. The terminal is charged by two Pelletron chains. The acceleration tube is a metal and ceramic construction made into tube sections with a length of 30 cm each. This tube design adds 27% more live ceramic than in the standard NEC tube design, which had heated apertures in 5 cm long shorted regions every 20 cm. The column structure and tube design are reviewed. (orig.)

The evaluation of validity of the RELAP5/Mod3 flow regime map for horizontal small diameter tubes at low pressure

Energy Technology Data Exchange (ETDEWEB)

Agafonova, N. [St. Petersburg State Technical Univ. (Russian Federation); Banati, J. [Lappeenranta Univ. of Technology (Finland)

1997-12-31

RELAP5/MOD3 code was developed for Western type power water reactors with vertical steam generators. Thus, this code should be validated also for WWER design with horizontal steam generators. In application for horizontal steam generators the situation with two-phase flow inside small diameter tubes is possible when the first circuit pressure drops in accident below the pressure level in the boiling water. It is known that computer codes have not always modelled correctly the two-phase flow inside horizontal tubes at low pressures (less than 4-6 MPa). It may be the result of erroneous prediction of the flow regime. Correct prediction of the flow regime is especially important for the fully or partly stratified flow in horizontal tubes. The aim of this study is the attempt of verification of the flow regime map, which is used in the RELAP5/MOD3 computer code for two-phase flow in horizontal small diameter tubes. `Small diameter tube` means according RELAP5/MOD3 that the inner diameter of the tube is less (or equal) than 0.018 m. The inner tube diameter in horizontal steam generators is equal 0.013 m. (orig.). 19 refs.

The evaluation of validity of the RELAP5/Mod3 flow regime map for horizontal small diameter tubes at low pressure

Energy Technology Data Exchange (ETDEWEB)

Agafonova, N [St. Petersburg State Technical Univ. (Russian Federation); Banati, J [Lappeenranta Univ. of Technology (Finland)

1998-12-31

RELAP5/MOD3 code was developed for Western type power water reactors with vertical steam generators. Thus, this code should be validated also for WWER design with horizontal steam generators. In application for horizontal steam generators the situation with two-phase flow inside small diameter tubes is possible when the first circuit pressure drops in accident below the pressure level in the boiling water. It is known that computer codes have not always modelled correctly the two-phase flow inside horizontal tubes at low pressures (less than 4-6 MPa). It may be the result of erroneous prediction of the flow regime. Correct prediction of the flow regime is especially important for the fully or partly stratified flow in horizontal tubes. The aim of this study is the attempt of verification of the flow regime map, which is used in the RELAP5/MOD3 computer code for two-phase flow in horizontal small diameter tubes. `Small diameter tube` means according RELAP5/MOD3 that the inner diameter of the tube is less (or equal) than 0.018 m. The inner tube diameter in horizontal steam generators is equal 0.013 m. (orig.). 19 refs.

Effectiveness of the diabetes education and self management for ongoing and newly diagnosed (DESMOND) programme for people with newly diagnosed type 2 diabetes

DEFF Research Database (Denmark)

Davies, M. J.; Heller, S.; Skinner, T. C.

2008-01-01

.001); directions of change were positive indicating greater understanding of diabetes. The intervention group had a lower depression score at 12 months: mean difference was -0.50 (95% confidence interval -0.96 to -0.04); P=0.032. A positive association was found between change in perceived personal responsibility....... Main outcome measures: Haemoglobin A1c levels, blood pressure, weight, blood lipid levels, smoking status, physical activity, quality of life, beliefs about illness, depression, and emotional impact of diabetes at baseline and up to 12 months. Main results: Haemoglobin A1c levels at 12 months had...... and weight loss at 12 months (β=0.12; P=0.008). Conclusion: A structured group education programme for patients with newly diagnosed type 2 diabetes resulted in greater improvements in weight loss and smoking cessation and positive improvements in beliefs about illness but no difference in haemoglobin A 1c...

Numerical simulations of a horizontal axis water turbine designed for underwater mooring platforms

Directory of Open Access Journals (Sweden)

Wenlong Tian

2016-01-01

Full Text Available In order to extend the operational life of Underwater Moored Platforms (UMPs, a horizontal axis water turbine is designed to supply energy for the UMPs. The turbine, equipped with controllable blades, can be opened to generate power and charge the UMPs in moored state. Three-dimensional Computational Fluid Dynamics (CFD simulations are performed to study the characteristics of power, thrust and the wake of the turbine. Particularly, the effect of the installation position of the turbine is considered. Simulations are based on the Reynolds Averaged Navier-Stokes (RANS equations and the shear stress transport k-ω turbulent model is utilized. The numerical method is validated using existing experimental data. The simulation results show that this turbine has a maximum power coefficient of 0.327 when the turbine is installed near the tail of the UMP. The flow structure near the blade and in the wake are also discussed.

Treatment of malignant gastroduodenal obstruction with using a newly designed complex expandable nitinol stent: initial experiences

International Nuclear Information System (INIS)

Jung, Mi Hee; Ko, Ji Ho; Lee, Eun Jung; Oh, Kyeng Seung; Huh, Jin Do; Cho, Young Duk; Park, Seun Ja; Jung, Gyoo Sik

2005-01-01

We wanted to evaluate the usefulness of a new type of a complex expandable nitinol stent that was designed to reduce the stent's propensity to migration during the treatment of malignant gastroduodenal obstructions. Two types of expandable nitinol stent were constructed by weaving a single thread of 0.2mm nitinol wire in a tubular configuration: an uncovered stent 18mm in diameter and a covered stent 16mm in diameter. Both ends of the covered stent were fabricated by coaxially inserting the covered stent into the tubular uncovered stent and then attaching the two stents together with using nylon monofilament. Under fluoroscopic guidance, the stent was placed in 29 consecutive patients (20 men and 9 women, mean age: 65 years) who were suffering with malignant gastric outlet obstruction (n=20), duodenal obstruction (n=6) or combined obstruction (n=3). Clinical improvement was assessed by comparing the food intake capacity before and after the procedure. The complications were investigated during the follow up period. Stent placement was successful in all the patients. After stent placement, the symptoms improved in all but one patient. During the follow up, stent migration occurred in one patient (3%) at 34 days after the procedure. Despite the stent migration, the patient was able to resume a soft diet. Six patients developed recurrent symptoms of obstruction with tumor overgrowth at a mean of 145 days after the procedure; all the patients underwent coaxial placement of an additional stent with good results. One patient showed recurrence of obstruction due to tumor in-growth, and this was treated by placement of a second stent. Two patients with stent placement in the duodenum suffered from jaundice 26 days and 65 days, respectively, after their procedures. Placement of the newly designed complex expandable nitinol stent seems to be effective for the palliative treatment of malignant gastroduodenal obstructions. The new stent also seems to help overcome the

Treatment of malignant gastroduodenal obstruction with using a newly designed complex expandable nitinol stent: initial experiences

Energy Technology Data Exchange (ETDEWEB)

Jung, Mi Hee; Ko, Ji Ho; Lee, Eun Jung; Oh, Kyeng Seung; Huh, Jin Do; Cho, Young Duk; Park, Seun Ja [College of Medicine, Kosin University, Busan (Korea, Republic of); Jung, Gyoo Sik [Ulsan Hospital, Ulsan (Korea, Republic of)

2005-12-15

We wanted to evaluate the usefulness of a new type of a complex expandable nitinol stent that was designed to reduce the stent's propensity to migration during the treatment of malignant gastroduodenal obstructions. Two types of expandable nitinol stent were constructed by weaving a single thread of 0.2mm nitinol wire in a tubular configuration: an uncovered stent 18mm in diameter and a covered stent 16mm in diameter. Both ends of the covered stent were fabricated by coaxially inserting the covered stent into the tubular uncovered stent and then attaching the two stents together with using nylon monofilament. Under fluoroscopic guidance, the stent was placed in 29 consecutive patients (20 men and 9 women, mean age: 65 years) who were suffering with malignant gastric outlet obstruction (n=20), duodenal obstruction (n=6) or combined obstruction (n=3). Clinical improvement was assessed by comparing the food intake capacity before and after the procedure. The complications were investigated during the follow up period. Stent placement was successful in all the patients. After stent placement, the symptoms improved in all but one patient. During the follow up, stent migration occurred in one patient (3%) at 34 days after the procedure. Despite the stent migration, the patient was able to resume a soft diet. Six patients developed recurrent symptoms of obstruction with tumor overgrowth at a mean of 145 days after the procedure; all the patients underwent coaxial placement of an additional stent with good results. One patient showed recurrence of obstruction due to tumor in-growth, and this was treated by placement of a second stent. Two patients with stent placement in the duodenum suffered from jaundice 26 days and 65 days, respectively, after their procedures. Placement of the newly designed complex expandable nitinol stent seems to be effective for the palliative treatment of malignant gastroduodenal obstructions. The new stent also seems to help overcome the

Output characteristics of torsion arc blade type horizontal axis windmill; Nejire enko yokugata suiheijiku fusha no shutsuryoku tokusei

Energy Technology Data Exchange (ETDEWEB)

Kojima, N; Kishimura, K [Meiji University, Tokyo (Japan)

1997-11-25

The previous paper theoretically analyzes characteristics of a torsion arc blade type (TABT) horizontal axis windmill to derive the theoretical equations, which give the results in good agreement with the observed ones, when multiplied by a blade shape factor. This paper discusses that the theoretical and observed results are in good agreement with each other by taking into consideration shape-related solidity and number of blades. The following findings are obtained, when parameters related to a 6-blade TABT horizontal axis wind mill are introduced and hysteresis brake is used as the load resistance for torque measurement. Shape factor can be represented by two factors of blade number and solidity. The same equation for shape factor is applicable to both elliptical and rectangular blades. These blades need different theoretical equations to give the results in agreement with the observed ones, when operated at a tip speed ratio (TSR) of 1.77 and 1.58, respectively. Rotational force is affected by the rear blade shape when they are operated at a respective TSR below the above level, but unaffected at beyond the above level. 5 refs., 9 figs., 1 tab.

Interpretation of horizontal well performance in complicated systems by the boundary element method

Energy Technology Data Exchange (ETDEWEB)

Jongkittinarukorn, K.; Tiab, D. [Oklahoma Univ., School of Petroleum and Geological Engineering (United States); Escobar, F. H. [Surcolombiana Univ., Dept. of Petroleum Engineering (Colombia)

1998-12-31

A solution obtained by using the boundary element method to simulate pressure behaviour of horizontal wells in complicated reservoir-wellbore configurations is presented. Three different types of well bore and reservoir models were studied, i.e. a snake-shaped horizontal wellbore intersecting a two-layer reservoir with cross flow, a horizontal well in a three-layer reservoir with cross flow, and a vertical well intersecting a two-layer reservoir without cross flow. In each case, special attention was paid to the influence of wellbore inclination angle, the distance from the wellbore to the different boundaries and the permeability ratio. Performance of each of these types of wells are discussed. 9 refs., 18 figs.

Surveying and analyzing injection responses for patterns with horizontal wells

Energy Technology Data Exchange (ETDEWEB)

Fedenczuk, L.; Hoffman, K.

1998-12-31

A novel method for visualizing injection responses in patterns that include horizontal and/or vertical wells is described. Understanding fluid communication between the horizontal well and the surrounding injectors is essential to estimating the effectiveness of the waterflood. Armed with the understanding of responses, injection patterns can be optimized, production rates can be increased and more efficient oil recovery can be achieved. In this study the time lags of correlations and a new parameter, the waterflood response type is introduced. The response type is based on the oil and total fluid responses. In addition spider diagrams are introduced to help visualizing the correlations, time lags and response types. Integration of the results with geology, petrophysics and completion techniques can help to find the cause and effect rules in waterflood fields. 6 refs., 10 figs.

Pre design processing of waste of ex-resin without materials matrix from nuclear power plant type PWR 1000 MW

International Nuclear Information System (INIS)

Cerdas Tarigan

2010-01-01

Have been done pre design processing of waste ex-resin without capacities matrix materials from nuclear power plant type PWR 1000 MW During the time radioactive waste of ex-resin processed to use process of immobilization use matrix materials like mixture cement and epoxy resin and then conditioning. This process is not effective and efficient because end result volume of end product bigger than volume early operation system and maintenance of its installation more difficult. To overcome this created a design of technology processing of waste of ex- resin without matrix materials through process of strainer, drying and conditioning represent technological innovation newly processing of radioactive waste of ex-resin. Besides this process more effective and efficient, volume of end product waste much more small from volume early and operation system and maintenance of its easier installation. Pre design is expected to be used as a basis to make conceptual of pre design installation of strainer, drying and conditioning for the processing of waste of ex-resin from nuclear power plant type PWR 1000 MW. (author)

Neutronics Design of Helical Type DEMO Reactor FFHR-d1

Energy Technology Data Exchange (ETDEWEB)

Tanaka, T.; Sagara, A.; Goto, T.; Yanagi, N.; Masuzaki, S.; Tamura, H.; Miyazawa, J.; Muroga, T., E-mail: teru@nifs.ac.jp [National Institute for Fusion Science, Toki (Japan)

2012-09-15

Full text: Neutronics design study has been performed in a newly started conceptual design activity for a helical type DEMO reactor FFHR-d1. Features of the FFHR-d1 design are enlargement of the basic configurations of reactor components and extrapolation of plasma parameters from those of the helical type plasma experimental machine Large Helical Device (LHD) to achieve the highest feasibility. From the neutronics point of view, a blanket space of FFHR-d1 is severely limited at the inboard of the torus. This is due to the core plasma position shifting to the inboard side under the confinement condition extrapolated from LHD. The first step of the neutronics investigation using the MCNP code has been performed with a simple torus model simulating thin inboard blanket space. A Flibe+Be/Ferritic steel breeding blanket showed preferable performances for both tritium breeding and shielding, and has been adapted as a reference blanket system for FFHR-d1. The investigations indicate that a combination of a 15 cm thick breeding blanket, 55 cm thick WC+B4C shield, i.e., the blanket space of 70 cm, could suppress the fast neutron flux and nuclear heating in the helical coils to the design targets for the neutron wall loading of 1.5 MW/m{sup 2}. Since the outboard side can provide a large space for a 60 cm thick breeding blanket, a fully-covered tritium breeding ratio (TBR) of 1.31 has been obtained in the simple torus model. The neutronics design study has proceeded to the second step using a 3-D helical reactor model. The most important issue in the 3-D neutronics design is a compatibility with the helical divertor design. To achieve a higher TBR and shielding performance, the core plasma has to be covered by the breeding blanket layers as possible. However, the dimensions of the blanket layers are limited by magnetic field lines connecting an edge of the core plasma and divertor pumping ports. After repeating modification of the blanket configuration, the global TBR of 1

Characteristic Value Method of Well Test Analysis for Horizontal Gas Well

Directory of Open Access Journals (Sweden)

Xiao-Ping Li

2014-01-01

Full Text Available This paper presents a study of characteristic value method of well test analysis for horizontal gas well. Owing to the complicated seepage flow mechanism in horizontal gas well and the difficulty in the analysis of transient pressure test data, this paper establishes the mathematical models of well test analysis for horizontal gas well with different inner and outer boundary conditions. On the basis of obtaining the solutions of the mathematical models, several type curves are plotted with Stehfest inversion algorithm. For gas reservoir with closed outer boundary in vertical direction and infinite outer boundary in horizontal direction, while considering the effect of wellbore storage and skin effect, the pseudopressure behavior of the horizontal gas well can manifest four characteristic periods: pure wellbore storage period, early vertical radial flow period, early linear flow period, and late horizontal pseudoradial flow period. For gas reservoir with closed outer boundary both in vertical and horizontal directions, the pseudopressure behavior of the horizontal gas well adds the pseudosteady state flow period which appears after the boundary response. For gas reservoir with closed outer boundary in vertical direction and constant pressure outer boundary in horizontal direction, the pseudopressure behavior of the horizontal gas well adds the steady state flow period which appears after the boundary response. According to the characteristic lines which are manifested by pseudopressure derivative curve of each flow period, formulas are developed to obtain horizontal permeability, vertical permeability, skin factor, reservoir pressure, and pore volume of the gas reservoir, and thus the characteristic value method of well test analysis for horizontal gas well is established. Finally, the example study verifies that the new method is reliable. Characteristic value method of well test analysis for horizontal gas well makes the well test analysis

Heavy crude production from shallow formations: long horizontal wells versus horizontal fractures

Energy Technology Data Exchange (ETDEWEB)

Valko, P.; Economides, M. J. [Texas A and M Univ., TX (United States)

1998-12-31

The feasibility of producing heavy oil from shallow formations using either horizontal wells or short horizontal wells fractured horizontally is demonstrated. The problem of optimum proppant placement is solved in two steps. In step one, the finite productivity performance is considered in general terms showing that the performance is a function of two dimensionless parameters. Following derivation of optimum conditions, the solution is applied to the horizontal fracture consideration. The limiting factor is that to create an effective finite conductivity fracture, the dimensionless fracture conductivity must be on the order of unity, a fracture that is difficult to realize in higher permeability formations. The best candidates for the suggested configuration are shallow or moderate formations, or formations otherwise proven to accept horizontal fractures, and formations with low permeability/viscosity ratio. 7 refs., 2 tabs., 10 figs., 2 appendices.

Production and partial characterization of lipases from a newly isolated Penicillium sp. using experimental design.

Science.gov (United States)

Wolski, E; Rigo, E; Di Luccio, M; Oliveira, J V; de Oliveira, D; Treichel, H

2009-07-01

The objective of this work was to investigate the lipase production by a newly isolated Penicillium sp., using experimental design technique, in submerged fermentation using a medium based on peptone, yeast extract, NaCl and olive oil, as well as to characterize the crude enzymatic extracts obtained. Lipase activity values of 9.5 U ml(-1) in 96 h of fermentation was obtained at the maximized operational conditions of peptone, yeast extract, NaCl and olive oil concentrations (g l(-1)) of 20.0, 5.0, 5.0 and of 10.0 respectively. The partial characterization of crude enzymatic extract obtained by submerged fermentation showed optimum activity at pH range from 4.9 to 5.5 and temperature from 37 degrees C to 42 degrees C. The crude extract maintained its initial activity at freezing temperatures up to 100 days. A newly isolated strain of Penicillium sp. used in this work yielded good lipase activities compared to the literature. The growing interest in lipase production is related to the potential biotechnological applications that these enzymes present. New lipase producers are relevant to finding enzymes with different catalytic properties of commercial interest could be obtained, without using genetically modified organisms (GMO).

Demonstration of in situ-constructed horizontal soil containment barrier at Fernald

International Nuclear Information System (INIS)

Pettit, P.J.; Ridenour, D.; Walker, J.; Saugier, K.

1994-01-01

A new design of jet grouting tool that can be guided by horizontal well casings and that operates in the horizontal plane has been used for the in situ placement of grout and construction of a prototype horizontal barrier that is free of windows. Jet grouting techniques have been advanced to permit construction of horizontal barriers underneath contaminated soil without having to excavate or disturb the waste. The paper describes progress on the Fernald Environmental Restoration Management Corporation (FERMCO) In Situ Land Containment Project which is sponsored by the US Department of Energy's (DOE) Office of Technology Development (OTD) for DOE's Fernald Environmental Management Project (FEMP). The Fernald project is to demonstrate a novel, enabling technology for the controlled underground placement of horizontal panels of grout, and the joining of adjacent panels to construct practical, extensive barriers. Construction strategy, equipment mechanics and operating details of this new method are described

Three-pattern decomposition of global atmospheric circulation: part II—dynamical equations of horizontal, meridional and zonal circulations

Science.gov (United States)

Hu, Shujuan; Cheng, Jianbo; Xu, Ming; Chou, Jifan

2018-04-01

The three-pattern decomposition of global atmospheric circulation (TPDGAC) partitions three-dimensional (3D) atmospheric circulation into horizontal, meridional and zonal components to study the 3D structures of global atmospheric circulation. This paper incorporates the three-pattern decomposition model (TPDM) into primitive equations of atmospheric dynamics and establishes a new set of dynamical equations of the horizontal, meridional and zonal circulations in which the operator properties are studied and energy conservation laws are preserved, as in the primitive equations. The physical significance of the newly established equations is demonstrated. Our findings reveal that the new equations are essentially the 3D vorticity equations of atmosphere and that the time evolution rules of the horizontal, meridional and zonal circulations can be described from the perspective of 3D vorticity evolution. The new set of dynamical equations includes decomposed expressions that can be used to explore the source terms of large-scale atmospheric circulation variations. A simplified model is presented to demonstrate the potential applications of the new equations for studying the dynamics of the Rossby, Hadley and Walker circulations. The model shows that the horizontal air temperature anomaly gradient (ATAG) induces changes in meridional and zonal circulations and promotes the baroclinic evolution of the horizontal circulation. The simplified model also indicates that the absolute vorticity of the horizontal circulation is not conserved, and its changes can be described by changes in the vertical vorticities of the meridional and zonal circulations. Moreover, the thermodynamic equation shows that the induced meridional and zonal circulations and advection transport by the horizontal circulation in turn cause a redistribution of the air temperature. The simplified model reveals the fundamental rules between the evolution of the air temperature and the horizontal, meridional

Structural Optimization Design of Horizontal-Axis Wind Turbine Blades Using a Particle Swarm Optimization Algorithm and Finite Element Method

Directory of Open Access Journals (Sweden)

Pan Pan

2012-11-01

Full Text Available This paper presents an optimization method for the structural design of horizontal-axis wind turbine (HAWT blades based on the particle swarm optimization algorithm (PSO combined with the finite element method (FEM. The main goal is to create an optimization tool and to demonstrate the potential improvements that could be brought to the structural design of HAWT blades. A multi-criteria constrained optimization design model pursued with respect to minimum mass of the blade is developed. The number and the location of layers in the spar cap and the positions of the shear webs are employed as the design variables, while the strain limit, blade/tower clearance limit and vibration limit are taken into account as the constraint conditions. The optimization of the design of a commercial 1.5 MW HAWT blade is carried out by combining the above method and design model under ultimate (extreme flap-wise load conditions. The optimization results are described and compared with the original design. It shows that the method used in this study is efficient and produces improved designs.

Relationship between ZnT8Ab, the SLC30A8 gene and disease progression in children with newly diagnosed type 1 diabetes

DEFF Research Database (Denmark)

Nielsen, L. B.; Vaziri-Sani, F.; Porksen, S.

2011-01-01

Autoantibodies against the newly established autoantigen in type 1 diabetes, zinc transporter 8, ZnT8, are presented as two types, ZnT8RAb and ZnT8WAb. The rs13266634 variant of the SLC30A8 gene has recently been found to determine the type of ZnT8Ab. The aim of this study was to explore the impact......8 gene is associated with preserved beta-cell function in type 1 diabetes patients. The genetic determination of the rs13266634 variant on the ZnT8Ab specificity is sustained the first 12 months after the diagnosis of type 1 diabetes in a pediatric cohort....

Nitrogen removal and its relationship with the nitrogen-cycle genes and microorganisms in the horizontal subsurface flow constructed wetlands with different design parameters.

Science.gov (United States)

Chen, Jun; Ying, Guang-Guo; Liu, You-Sheng; Wei, Xiao-Dong; Liu, Shuang-Shuang; He, Liang-Ying; Yang, Yong-Qiang; Chen, Fan-Rong

2017-07-03

This study aims to investigate nitrogen removal and its relationship with the nitrogen-cycle genes and microorganisms in the horizontal subsurface flow constructed wetlands (CWs) with different design parameters. Twelve mesocosm-scale CWs with four substrates and three hydraulic loading rates were set up in the outdoor. The result showed the CWs with zeolite as substrate and HLR of 20 cm/d were selected as the best choice for the TN and NH 3 -N removal. It was found that the single-stage mesocosm-scale CWs were incapable to achieve high removals of TN and NH 3 -N due to inefficient nitrification process in the systems. This was demonstrated by the lower abundance of the nitrification genes (AOA and AOB) than the denitrification genes (nirK and nirS), and the less diverse nitrification microorganisms than the denitrification microorganisms in the CWs. The results also show that microorganism community structure including nitrogen-cycle microorganisms in the constructed wetland systems was affected by the design parameters especially the substrate type. These findings show that nitrification is a limiting factor for the nitrogen removal by CWs.

Conceptual designs for waste packages for horizontal or vertical emplacement in a repository in salt for reference in the site characterization plan

International Nuclear Information System (INIS)

1987-06-01

This report includes the options of horizontal and vertical emplacement, the addition of a phased repository, an additional waste form (intact spent fuel), revised geotechnical data appropriate for the Deaf Smith County site, new corrosion data for the container, and new repository design data. The waste package consists of waste form and canister within a thick-walled, low-carbon steel container surrounded by packing. The container is a hollow cylinder with a flat head welded to each end. The design concepts for the waste container or vertical and horizontal emplacement are identical. This report discusses the results of analyses of aspects of the reference waste package concept needing changes because of new data and information believed applicable to the Deaf Smith County site. Included are waste package conceptual designs or (1) the reference defense high-level waste form from the Savannah River Plant; (2) intact spent fuel with our pressurized-water-reactor or nine boiling-water-reactor assemblies per package for emplacement during Phase 1 of repository operation; and (3) spent fuel which has been disassembled and consolidated into a segmented cylindrical canister with rods from either 12 pressurized-water-reactor or 30 boiling-water-reactor assemblies per package for emplacement during Phase 2. 30 refs., 61 figs., 30 tabs

Heterogenic final cell cycle by chicken retinal Lim1 horizontal progenitor cells leads to heteroploid cells with a remaining replicated genome.

Directory of Open Access Journals (Sweden)

Shahrzad Shirazi Fard

Full Text Available Retinal progenitor cells undergo apical mitoses during the process of interkinetic nuclear migration and newly generated post-mitotic neurons migrate to their prospective retinal layer. Whereas this is valid for most types of retinal neurons, chicken horizontal cells are generated by delayed non-apical mitoses from dedicated progenitors. The regulation of such final cell cycle is not well understood and we have studied how Lim1 expressing horizontal progenitor cells (HPCs exit the cell cycle. We have used markers for S- and G2/M-phase in combination with markers for cell cycle regulators Rb1, cyclin B1, cdc25C and p27Kip1 to characterise the final cell cycle of HPCs. The results show that Lim1+ HPCs are heterogenic with regards to when and during what phase they leave the final cell cycle. Not all horizontal cells were generated by a non-apical (basal mitosis; instead, the HPCs exhibited three different behaviours during the final cell cycle. Thirty-five percent of the Lim1+ horizontal cells was estimated to be generated by non-apical mitoses. The other horizontal cells were either generated by an interkinetic nuclear migration with an apical mitosis or by a cell cycle with an S-phase that was not followed by any mitosis. Such cells remain with replicated DNA and may be regarded as somatic heteroploids. The observed heterogeneity of the final cell cycle was also seen in the expression of Rb1, cyclin B1, cdc25C and p27Kip1. Phosphorylated Rb1-Ser608 was restricted to the Lim1+ cells that entered S-phase while cyclin B1 and cdc25C were exclusively expressed in HPCs having a basal mitosis. Only HPCs that leave the cell cycle after an apical mitosis expressed p27Kip1. We speculate that the cell cycle heterogeneity with formation of heteroploid cells may present a cellular context that contributes to the suggested propensity of these cells to generate cancer when the retinoblastoma gene is mutated.

Inelastic response of PCRV structure model with star-type support under horizontal loads

International Nuclear Information System (INIS)

Suzuki, T.; Yamaguchi, T.; Takeda, T.

1978-01-01

The report presents the test results of scaled models for prestressed concrete reactor vessel (PCRV) structure with star-shaped support under horizontal loads. A scale factor of 1 / 70 to a proto-type PCRV structure for large HTGR is used for both static and dynamic loading test models, while a 1 / 15 scaled model is used for static loading tests. The static behaviors such as a load-deflection envelope of the 1 / 70 model are predicted well by an inelastic analysis in consideration with appearance of concrete cracks and reinforcing bar yielding. It is also ascertained by the test results of the 1 / 15 model under static alternative loads that the same analysis procedure can be applicable to the evaluation of the elastic and inelastic behaviors of PCRV structure with support. Based on the static loading test results of both scaled models, a tri-linearized load-deflection envelope and an equivalent linearized mathematical model for hysteresis loop are assumed in a dynamic analysis. A dynamic response analysis of the 1 / 70 model subjected to earthquake-like base motion is conducted by the similar manner above-mentioned and the calculated results show a good correlation with the test results

Theory and design of heat exchanger : shell and tube condenser and reboiler

International Nuclear Information System (INIS)

Min, Ui Dong

1996-02-01

This book gives descriptions of shell and tube heat exchanger including from, sorts, structure like shell and shell side, channel, and sliding bar, basic design of heat exchanger, flow-induced vibration, shell side condenser, tube side condenser and design of basic structure of condenser by types, selection of reboiler type, kettle type reboiler, internal reboiler, pump through reboiler, design of reboiler like kettle and internal reboiler, and horizontal and vertical thermosyphon reboiler.

A newly-designed temporary cardia stent for the treatment of achalasia:an experimental study in canine models

International Nuclear Information System (INIS)

Kuang Xiaochun; Cheng Yingsheng; Zhu Yueqi; Li Feng; Wang Weiguo

2010-01-01

Objective: To assess the efficacy and safety of a newly-designed temporary covered cardia stent for the treatment of achalasia in canine models and to investigate the histopathological changes at different points of follow-up time after the stent was removed. Methods: The canine achalasia model was created by injecting benzyl-dimethyl-tetradecyl ammonium chloride (BAC) circumferentially into the lower esophageal sphincter (LES) of the dogs. Twenty-four dogs with achalasia were randomly and equally divided into two groups with 12 dogs in each group: control group (using routine esophageal stents) and study group (using newly-designed temporary covered cardia stents). Under fluoroscopic guidance stents were implanted in the esophagus and were taken away from the esophagus 4 days after stent insertion in experimental dogs of both groups. LES pressures and timed barium esophagography (TBE) were performed in all dogs before and immediately after the stenting procedure, as well as at one week, 3 and 6 months after the stent was removed. Every three dogs were sacrificed each time at one week, 3 and 6 months after the stent was removed. The esophageal cardia was excised and sent for pathological examination. Results: All animals well tolerated the stent insertion / removal and the follow-up procedures. No severe complications such as esophageal perforation occurred. Comparison between two groups showed that stent migration occurrence was much lower in study group (n = 1) than that in control group (n = 5). The reduction of LES pressures in study group was more significant in comparison with control group (at 6-month follow-up, P = 0.027). The difference in barium column product (height x width) between 0-min and 5-min TBE was statistically significant in study group (at 3-month follow-up, P = 0.009). Integrated analysis of multi-comparison for LES pressures among subgroups of each group revealed that the dogs in study group exhibited better outcomes than the dogs in

Levels of soluble TREM-1 in children with newly diagnosed type 1 diabetes and their siblings without type 1 diabetes

DEFF Research Database (Denmark)

Thorsen, Steffen U.; Pipper, Christian B.; Mortensen, Henrik B.

2017-01-01

BACKGROUND: Type 1 diabetes (T1D) is an organ-specific autoimmune disease with an increase in incidence worldwide including Denmark. The triggering receptor expressed on myeloid cells-1 (TREM-1) is a potent amplifier of pro-inflammatory responses and has been linked to autoimmunity, severe...... psychiatric disorders, sepsis, and cancer. HYPOTHESIS: Our primary hypothesis was that levels of soluble TREM-1 (sTREM-1) differed between newly diagnosed children with T1D and their siblings without T1D. METHODS: Since 1996, the Danish Childhood Diabetes Register has collected data on all patients who have......, which takes into account that measurements are left censored and accounts for correlation within siblings from the same family. RESULTS: In the multiple regression model (case status, gender, age, HLA-risk, season, and period of sampling), levels of sTREM-1 were found to be significantly higher...

Analytical model for the design of in situ horizontal permeable reactive barriers (HPRBs) for the mitigation of chlorinated solvent vapors in the unsaturated zone

NARCIS (Netherlands)

Verginelli, Iason; Capobianco, Oriana; Hartog, Niels; Baciocchi, Renato

In this work we introduce a 1-D analytical solution that can be used for the design of horizontal permeable reactive barriers (HPRBs) as a vapor mitigation system at sites contaminated by chlorinated solvents. The developed model incorporates a transient diffusion-dominated transport with a

Design, implementation, and evaluation at entry of a prospective cohort study of homosexual and bisexual HIV-1-negative men in Belo Horizonte, Brazil: Project Horizonte.

Science.gov (United States)

Carneiro, M; de Figueiredo Antunes, C M; Greco, M; Oliveira, E; Andrade, J; Lignani, L; Greco, D B

2000-10-01

Project Horizonte, an open cohort of homosexual and bisexual HIV-1-negative men, is a component of the Minas Gerais AIDS Vaccine Program of the Federal University of Minas Gerais, Belo Horizonte, Brazil. Its objectives included the evaluation of seroincidence of HIV, to ascertain the role of counseling on behavior modification and to assess their willingness to participate in future HIV vaccine trials. Various means of recruitment were used, including pamphlets, notices in community newspapers, radio, and television, at anonymous testing centers, and by word of mouth. From October 1994 to May 1999, 470 volunteers were enrolled. Their mean age was 26 years and over 70% of them had high school or college education. During the follow-up, they were seen every 6 months, when they received counseling and condoms, and when HIV testing was done. Eighteen seroconversions were observed, and the incidence rates estimates were 1.75 per 100 and 1.99 per 100 person-years, for 36 and 48 months of follow-up, respectively. During the entire period, 139 volunteers were lost to follow-up. Among them, 59 (42.4%) never returned after the initial visit and 51 (36.7) came only once after their initial visit. No losses were observed for those observed during follow-up for more than 3 years. At enrollment, 50% of participants said they would participate in a vaccine trial, and 30% said they might participate. The results obtained up to this moment confirm the feasibility of following this type of cohort for an extended period, estimating HIV incidence rate, and evaluating counseling for safe sexual practices in preparation for clinical trials with candidate HIV vaccines in Brazil.

Horizontal wells in subsurface remediation

International Nuclear Information System (INIS)

Losonsky, G.; Beljin, M.S.

1992-01-01

This paper reports on horizontal wells which offer an effective alternative to vertical wells in various environmental remediation technologies. Hydrogeological advantages of horizontal wells over vertical wells include a larger zone of influence, greater screen length, higher specific capacity and lower groundwater screen entrance velocity. Because of these advantages, horizontal wells can reduce treatment time and costs of groundwater recovery (pump-and-treat), in situ groundwater aeration (sparging) and soil gas extraction (vacuum extraction). Horizontal wells are also more effective than vertical wells in landfill leachate collection (under-drains), bioremediation, and horizontal grout injection

A STUDY TO CORRELATE HBA1C LEVELS AND LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN NEWLY DIAGNOSED TYPE II DIABETES MELLITUS

OpenAIRE

Vasanthi; Namitha; Jayanthi; Elangumanan; Mohamed; Uma Maheshwari; Pravin Selvam; Santhi

2016-01-01

AIM To assess the correlation of HBA1C levels with left ventricular diastolic dysfunction in newly diagnosed Type 2 diabetic patient. This prospective study was done at Department of General Medicine, OPD, Medical Wards, Stanley Medical College and Hospital, Chennai. RESULT The mean HBA1C levels were meaningfully more in Left Ventricular Diastolic Dysfunction (LVDD) positive group compared to the LVDD negative group by 1.33%. This significant difference of 15% increase in...

Reliability of buildings in service limit state for maximum horizontal displacements

Directory of Open Access Journals (Sweden)

A. G. B. Corelhano

Full Text Available Brazilian design code ABNT NBR6118:2003 - Design of Concrete Structures - Procedures - [1] proposes the use of simplified models for the consideration of non-linear material behavior in the evaluation of horizontal displacements in buildings. These models penalize stiffness of columns and beams, representing the effects of concrete cracking and avoiding costly physical non-linear analyses. The objectives of the present paper are to investigate the accuracy and uncertainty of these simplified models, as well as to evaluate the reliabilities of structures designed following ABNT NBR6118:2003[1&] in the service limit state for horizontal displacements. Model error statistics are obtained from 42 representative plane frames. The reliabilities of three typical (4, 8 and 12 floor buildings are evaluated, using the simplified models and a rigorous, physical and geometrical non-linear analysis. Results show that the 70/70 (column/beam stiffness reduction model is more accurate and less conservative than the 80/40 model. Results also show that ABNT NBR6118:2003 [1] design criteria for horizontal displacement limit states (masonry damage according to ACI 435.3R-68(1984 [10] are conservative, and result in reliability indexes which are larger than those recommended in EUROCODE [2] for irreversible service limit states.

Demonstration of a utility industry horizontal drilling system: Horizontal well AMH-5 installation report

International Nuclear Information System (INIS)

1992-01-01

The Department of Energy's Office of Technology Development initiated an integrated demonstration of innovative technologies and systems for cleanup of VOCs in soils and groundwater at the Savannah River Site (SRS) in 1989. The overall goal of the program is demonstration of multiple technologies and systems in the fields of drilling, characterization, monitoring, and remediation at a single test bed. Innovative technologies are compared to one another and to baseline technologies in terms of technical performance and cost effectiveness. Transfer of successfully demonstrated technologies and systems to DOE environmental restoration organizations, to other government agencies, and to industry is a critical part of the program. Directional drilling has been shown to be a successful technique for enhancing access to the subsurface, thus improving remediation systems, especially remediation systems which perform in situ. Demonstration of an innovative directional drilling system at the Integrated Demonstration Site at the SRS, was initiated in June of 1992. The directional drilling system was designed to install an in situ remediation system. The drilling system is an experimental compaction/dry drilling technique developed by Charles Machine Works (Ditch Witch reg-sign) of Perry, Oklahoma. A horizontal well was installed in the M Area of the SRS below and parallel to an abandoned tile process sewer line. The installation of the horizontal well was a two-part process. Part one consisted of drilling the borehole, and part two was the horizontal well completion

Exact Sight Distance Determination on Compound Vertical and Horizontal Curves in the Presence of Road Barriers

Directory of Open Access Journals (Sweden)

Chiu Liu, PhD, PE, PTOE

2013-06-01

Full Text Available The sight distance (SD on a three-dimensional (3-d compound curve has been studied recently in the absence of obstacles at road sides. Often, physical barriers are installed at road sides or in a roadway median for reducing potential collision severities; these rigid, semi-rigid, or even temporary cushion-type barriers can limit or reduce the driver's sight distance, depending on their horizontal offset distances away from the nearest edge of traveled way (ETW. The closer a barrier to the ETW is, the shorter the driver's sight distance would be. Since most barriers are constructed to prevent running-off road or crossing-median collisions, it is crucial to check whether the installation would reduce the driver's sight distance and potentially cause other traffic collisions such as rear-end or side swipe collisions. In this paper, an exact analytic framework is formulated with derived equations the first time to calculate the sight distance on a 3-d compound curve in the presence of a median barrier, a roadside barrier, or a temporary cushion or barrier used for construction or other maintenance purposes. This framework provides an engineer a handy tool to examine the possible change of SD in the presence of a barrier and choose the required horizontal offset/clearance of a barrier from the nearest traveled way edge to meet certain design criteria or standards. This critical offset distance determined using this framework not only reinforces the importance of having roadside clearance recovery zones on highways but also provides a method to determine its horizontal clearance from a different standpoint. This analytic framework can easily be programmed into an Excel spreadsheet to evaluate the design of a physical barrier and its potential influence on sight distance along a 3-d compound horizontal and vertical curve. Transportation engineers or practitioners may find this design tool handy and useful once the programmed spreadsheet is saved in a

Diabetes education and self-management for ongoing and newly diagnosed (DESMOND)

DEFF Research Database (Denmark)

Skinner, T. Chas; Carey, Marian E.; Cradock, Sue

2006-01-01

diagnosed with Type 2 diabetes changes key illness beliefs and that these changes predict quality of life and metabolic control at 3-month follow-up. Practice implications: Newly diagnosed individuals are open to attending self-management programs and, if the program is theoretically driven, can......Objective: To determine the effects of a structured education program on illness beliefs, quality of life and physical activity in people newly diagnosed with Type 2 diabetes. Methods: Individuals attending a diabetes education and self-management for ongoing and newly diagnosed (DESMOND) program...... in 12 Primary Care Trusts completed questionnaire booklets assessing illness beliefs and quality of life at baseline and 3-month follow-up, metabolic control being assessed through assay of HbA1c. Results: Two hundred and thirty-six individuals attended the structured self-management education sessions...

Heat transfer by natural convection into an horizontal cavity; Transferencia de calor por conveccion natural en una cavidad horizontal

Energy Technology Data Exchange (ETDEWEB)

Arevalo J, P

1998-12-31

At this thesis it is studied the heat transfer by natural convection in an horizontal cavity, it is involved a boiling`s part that is described the regimes and correlations differences for boiling`s curve. It is designed a horizontal cavity for realize the experimental part and it`s mention from equipment or instrumentation to succeed in a experimentation that permits to realize the analysis of heat transfer, handling as water fluid at atmospheric pressure and where it`s present process from natural convection involving part boiling`s subcooled. The system consists of heater zone submerged in a horizontal cavity with water. Once part finished experimental with information to obtained it`s proceeded to obtain a correlation, realized starting from analysis dimensionless such as: Jakob, Bond and Grasoft (Boiling) besides of knows in natural convection: Prandtl and Nusselt. The mathematical model explains the behavior for natural convection continued part boiling`s subcooled. It is realize analysis graphics too where it`s show comparing with Globe Dropkin and Catton equations by natural convection with bottom heating. (Author)

Heat transfer by natural convection into an horizontal cavity; Transferencia de calor por conveccion natural en una cavidad horizontal

Energy Technology Data Exchange (ETDEWEB)

Arevalo J, P

1999-12-31

At this thesis it is studied the heat transfer by natural convection in an horizontal cavity, it is involved a boiling`s part that is described the regimes and correlations differences for boiling`s curve. It is designed a horizontal cavity for realize the experimental part and it`s mention from equipment or instrumentation to succeed in a experimentation that permits to realize the analysis of heat transfer, handling as water fluid at atmospheric pressure and where it`s present process from natural convection involving part boiling`s subcooled. The system consists of heater zone submerged in a horizontal cavity with water. Once part finished experimental with information to obtained it`s proceeded to obtain a correlation, realized starting from analysis dimensionless such as: Jakob, Bond and Grasoft (Boiling) besides of knows in natural convection: Prandtl and Nusselt. The mathematical model explains the behavior for natural convection continued part boiling`s subcooled. It is realize analysis graphics too where it`s show comparing with Globe Dropkin and Catton equations by natural convection with bottom heating. (Author)

Horizontal transfer generates genetic variation in an asexual pathogen

Directory of Open Access Journals (Sweden)

Xiaoqiu Huang

2014-10-01

Full Text Available There are major gaps in the understanding of how genetic variation is generated in the asexual pathogen Verticillium dahliae. On the one hand, V. dahliae is a haploid organism that reproduces clonally. On the other hand, single-nucleotide polymorphisms and chromosomal rearrangements were found between V. dahliae strains. Lineage-specific (LS regions comprising about 5% of the genome are highly variable between V. dahliae strains. Nonetheless, it is unknown whether horizontal gene transfer plays a major role in generating genetic variation in V. dahliae. Here, we analyzed a previously sequenced V. dahliae population of nine strains from various geographical locations and hosts. We found highly homologous elements in LS regions of each strain; LS regions of V. dahliae strain JR2 are much richer in highly homologous elements than the core genome. In addition, we discovered, in LS regions of JR2, several structural forms of nonhomologous recombination, and two or three homologous sequence types of each form, with almost each sequence type present in an LS region of another strain. A large section of one of the forms is known to be horizontally transferred between V. dahliae strains. We unexpectedly found that 350 kilobases of dynamic LS regions were much more conserved than the core genome between V. dahliae and a closely related species (V. albo-atrum, suggesting that these LS regions were horizontally transferred recently. Our results support the view that genetic variation in LS regions is generated by horizontal transfer between strains, and by chromosomal reshuffling reported previously.

Horizontal loading test by whole model specimen simulating inner concrete structure of PWR type nuclear power plant

International Nuclear Information System (INIS)

Furuya, Noriyuki; Sekine, Masataka; Kimura, Kozo; Yamaguchi, Yoshihiro; Yamaguchi, Tsuneo; Takeda, Toshikazu

1985-01-01

The Nuclear Power Engineering Test Center has performed a horizontal loading test by a whole model specimen simulating the inner concrete structure of a PWR type nuclear power plant in order to investigate restoring force characteristics of reactor buildings. This report describes the results of examination of applicability to the test results of analysis methods based on elastic theory. The analysis results of elastic stiffness, concrete cracking load, rebar yielding loads and ultimate strength were compared with the test results. According to this examination, it is recognized that even these analysis methods based on elastic theory are comparatively effective for analysis of an inner concrete structure of fairly complex configuration, although there are limits of the scope of applicability. (author)

NUMERICAL DETERMINATION OF HORIZONTAL SETTLERS PERFORMANCE

Directory of Open Access Journals (Sweden)

M. M. Biliaiev

2015-08-01

Full Text Available Purpose.Horizontal settlers are one of the most important elements in the technological scheme of water purification. Their use is associated with the possibility to pass a sufficiently large volume of water. The important task at the stage of their designing is evaluating of their effectiveness. Calculation of the efficiency of the settler can be made by mathematical modeling. Empirical, analytical models and techniques that are currently used to solve the problem, do not allow to take into account the shape of the sump and various design features that significantly affects the loyalty to a decision on the choice of the size of the settling tank and its design features. The use of analytical models is limited only to one-dimensional solutions, does not allow accounting for nonuniform velocity field of the flow in the settler. The use of advanced turbulence models for the calculation of the hydrodynamics in the settler complex forms now requires very powerful computers. In addition, the calculation of one variant of the settler may last for dozens of hours. The aim of the paper is to build a numerical model to evaluate the effectiveness of horizontal settling tank modified design. Methodology. Numerical models are based on: 1 equation of potential flow; 2 equation of inviscid fluid vortex flow; 3 equation of viscous fluid dynamics; 4 mass transfer equation. For numerical simulation the finite difference schemes are used. The numerical calculation is carried out on a rectangular grid. For the formation of the computational domain markers are used. Findings.The models allow calculating the clarification process in the settler with different form and different configuration of baffles. Originality. A new approach to investigate the mass transfer process in horizontal settler was proposed. This approach is based on the developed CFD models. Three fluid dynamics models were used for the numerical investigation of flows and waste waters purification

Electron-shading effect on the horizontal aligned growth of carbon nanotubes

International Nuclear Information System (INIS)

Chai Yang; Xiao Zhiyong; Chan, Philip C. H.

2009-01-01

Based on the well-accepted electron-shading theory during plasma processing, we designed microstructures to control the local built-in electric-field on the substrate surface. The distortion magnitude of the electric-field is largest near the sidewalls of the microstructures, creating a horizontal electric-field in this region. We showed that the horizontally aligned carbon nanotubes (CNTs) were grown by making use of this built-in electric-field during the plasma-enhanced chemical vapor deposition process, with a tactical choice of geometries and materials of the microstructures on the substrate. This technique opens up a way to selectively and controllably grow horizontally aligned CNTs on the substrate surface

24-CHANNEL GEOPHONE ARRAY FOR HORIZONTAL OR VERTICAL BOREHOLES

Energy Technology Data Exchange (ETDEWEB)

Erik C. Westman

2003-10-24

Improved ground-imaging capabilities have enormous potential to increase energy, environmental, and economic benefits by improving exploration accuracy and reducing energy consumption during the mining cycle. Seismic tomography has been used successfully to monitor and evaluate geologic conditions ahead of a mining face. A primary limitation to existing seismic tomography, however, is the placement of sensors. The goal of this project is to develop an array of 24 seismic sensors capable of being mounted in either a vertical or horizontal borehole. Development of this technology reduces energy usage in excavation, transportation, ventilation, and processing phases of the mining operation because less waste is mined and the mining cycle suffers fewer interruptions. This new technology benefits all types of mines, including metal/nonmetal, coal, and quarrying. The primary research tasks focused on sensor placement method, sensor housing and clamping design, and cabling and connector selection. An initial design is described in the report. Following assembly, a prototype was tested in the laboratory as well as at a surface stone quarry. Data analysis and tool performance were used for subsequent design modifications. A final design is described, of which several components are available for patent application. Industry partners have shown clear support for this research and demonstrated an interest in commercialization following project completion.

Horizontal oil well applications and oil recovery assessment. Volume 2: Applications overview, Final report

Energy Technology Data Exchange (ETDEWEB)

Deskins, W.G.; McDonald, W.J.; Knoll, R.G.; Springer, S.J.

1995-03-01

Horizontal technology has been applied in over 110 formations in the USA. Volume 1 of this study addresses the overall success of horizontal technology, especially in less-publicized formations, i.e., other than the Austin Chalk, Bakken, and Niobrara. Operators in the USA and Canada were surveyed on a formation-by-formation basis by means of a questionnaire. Response data were received describing horizontal well projects in 58 formations in the USA and 88 in Canada. Operators` responses were analyzed for trends in technical and economic success based on lithology (clastics and carbonates) and resource type (light oil, heavy oil, and gas). The potential impact of horizontal technology on reserves was also estimated. A forecast of horizontal drilling activity over the next decade was developed.

A comparative pressure analysis of air flow between horizontal and V-Tail of UAV MALE of NACA0012H with speed variation

Directory of Open Access Journals (Sweden)

Riza Rahmat

2018-01-01

Full Text Available NACA0012H is an airfoil type that could be used for Unmanned Aerial Vehicle Medium Altitude Long Endurance. This experiment was used to analyze stress in the surface of Tail of UAV MALE that was caused by air flow. The experiment was conducted using Computational Fluid Dynamics Software. Two designs of tail, horizontal and V-tail, were considered to simulate pressure occurred on the surface of leading edge, chamber and trailing edge. The simulation was developed varying the speed of the UAV MALE. The results showed that pressure occurred on the surface of horizontal tail higher than pressure on the V-tail.

Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes

Science.gov (United States)

Falconer, C.L.; Cooper, A.R.; Walhin, J.P.; Thompson, D.; Page, A.S.; Peters, T.J.; Montgomery, A.A.; Sharp, D.J.; Dayan, C.M.; Andrews, R.C.

2014-01-01

Background and aims We investigated whether objectively measured sedentary time was associated with markers of inflammation in adults with newly diagnosed type 2 diabetes. Methods and results We studied 285 adults (184 men, 101 women, mean age 59.0 ± 9.7) who had been recruited to the Early ACTivity in Diabetes (Early ACTID) randomised controlled trial. C-reactive protein (CRP), adiponectin, soluble intracellular adhesion molecule-1 (sICAM-1), interleukin-6 (IL-6), and accelerometer-determined sedentary time and moderate-vigorous physical activity (MVPA) were measured at baseline and after six-months. Linear regression analysis was used to investigate the independent cross-sectional and longitudinal associations of sedentary time with markers of inflammation. At baseline, associations between sedentary time and IL-6 were observed in men and women, an association that was attenuated following adjustment for waist circumference. After 6 months of follow-up, sedentary time was reduced by 0.4 ± 1.2 h per day in women, with the change in sedentary time predicting CRP at follow-up. Every hour decrease in sedentary time between baseline and six-months was associated with 24% (1, 48) lower CRP. No changes in sedentary time between baseline and 6 months were seen in men. Conclusions Higher sedentary time is associated with IL-6 in men and women with type 2 diabetes, and reducing sedentary time is associated with improved levels of CRP in women. Interventions to reduce sedentary time may help to reduce inflammation in women with type 2 diabetes. PMID:24925122

Alternativa estructural de refuerzo horizontal en muros de mampostería Structural alternative of horizontal reinforcement in masonry walls

Directory of Open Access Journals (Sweden)

Diego Fernando Páez Moreno

2009-01-01

Full Text Available La implementación de refuerzo horizontal en muros de mampostería con ladrillo macizo de arcilla cocida es una técnica empleada en varios países. En este trabajo se propone un análisis para muros de mampostería representativos de la ciudad de Tunja con la implementación de grafiles de acero como alternativa de refuerzo horizontal. Este estudio involucra la definición de los tipos de materiales a emplear, las características de los muros a ensayar y las variables que se deben aplicar, tanto en los muros como en la ejecución del ensayo de compresión diagonal, que define tipos de muros con características propias de refuerzo. Los resultados del proceso de análisis del comportamiento individual y general de los muros de mampostería sometidos al ensayo de compresión diagonal permiten identificar la variación del esfuerzo cortante representativo para cada tipo de muro, en relación con el refuerzo empleado en los diferentes modelos y la tipología de falla.Implementation of horizontal reinforcement in masonry walls with solid cooked clay bricks is a commonly used technique in several countries. This article is intended to analyze masonry walls representatives of Tunja City, with implementation of small steel bars as an alternative of horizontal reinforcement. This study involves definition of types of materials to be used, characteristics of walls to be tested, and variables which should be applied in both walls and during the execution of the diagonal compression test which defines the types of walls with own characteristics of reinforcement. Results from individual and general behavior analysis process of masonry walls subject to diagonal compression tests allow identifying variation of shear stress for each kind of wall, in relation to reinforcement used in several models and failure typology.

Principal permeability determination from multiple horizontal well tests

Energy Technology Data Exchange (ETDEWEB)

Economides, M. [Texas A and M Univ., TX (United States); Munoz, A.; Ehlig-Economides, C.

1998-12-31

A method for obtaining principal permeability magnitudes and direction that requires only the linear flow regime from transient tests in three horizontal wells oriented in three distinct and arbitrary directions, is described. Well design optimization strategies require knowledge of both the principal permeability orientation as well as the horizontal permeability magnitudes. When the degree of horizontal permeability anisotropy (i.e. permeability in the bedding plane with respect to direction) is significant, the productivity of a long horizontal well will depend greatly on its direction, especially when the well is first brought into production. Productivities have been found to deviate substantially among wells in the same reservoir and this deviation has been attributed to differences in well orientation. In view of this fact, measuring permeability anisotropy becomes a compelling necessity. The success of the proposed method is illustrated by a case study in which the principal permeability magnitudes and direction from three wells were used to predict the productivity of a fourth well within 10 per cent. Use of the computed principal permeabilities from the case study, it was possible to forecast the cumulative production to show the significance of well trajectory optimization on the discounted cash flow and the net present value. 20 refs., 3 figs.

Newly graduated nurses' use of knowledge sources in clinical decision-making

DEFF Research Database (Denmark)

Voldbjerg, Siri Lygum; Grønkjaer, Mette; Wiechula, Rick

2017-01-01

AIMS AND OBJECTIVES: To explore which knowledge sources newly graduated nurses' use in clinical decision-making and why and how they are used. BACKGROUND: In spite of an increased educational focus on skills and competencies within evidence based practice newly graduated nurses' ability to use...... approaches to strengthen the knowledgebase used in clinical decision-making. DESIGN AND METHODS: Ethnographic study using participant-observation and individual semi-structured interviews of nine Danish newly graduated nurses in medical and surgical hospital settings. RESULTS: Newly graduates use...... in clinical decision-making. If newly graduates are to be supported in an articulate and reflective use of a variety of sources, they have to be allocated to experienced nurses who model a reflective, articulate and balanced use of knowledge sources. This article is protected by copyright. All rights reserved....

Design and numerical simulation on an auto-cumulative flowmeter in horizontal oil-water two-phase flow.

Science.gov (United States)

Xie, Beibei; Kong, Lingfu; Kong, Deming; Kong, Weihang; Li, Lei; Liu, Xingbin; Chen, Jiliang

2017-11-01

In order to accurately measure the flow rate under the low yield horizontal well conditions, an auto-cumulative flowmeter (ACF) was proposed. Using the proposed flowmeter, the oil flow rate in horizontal oil-water two-phase segregated flow can be finely extracted. The computational fluid dynamics software Fluent was used to simulate the fluid of the ACF in oil-water two-phase flow. In order to calibrate the simulation measurement of the ACF, a novel oil flow rate measurement method was further proposed. The models of the ACF were simulated to obtain and calibrate the oil flow rate under different total flow rates and oil cuts. Using the finite-element method, the structure of the seven conductance probes in the ACF was simulated. The response values for the probes of the ACF under the conditions of oil-water segregated flow were obtained. The experiments for oil-water segregated flow under different heights of the oil accumulation in horizontal oil-water two-phase flow were carried out to calibrate the ACF. The validity of the oil flow rate measurement in horizontal oil-water two-phase flow was verified by simulation and experimental results.

Parametric study on off-design aerodynamic performance of a horizontal axis wind turbine blade and proposed pitch control

International Nuclear Information System (INIS)

Najafian Ashrafi, Z.; Ghaderi, M.; Sedaghat, A.

2015-01-01

Highlights: • A pitch controlled 200 kW HAWT blade is designed with BEM for off-design conditions. • Parametric study conducted on power coefficient, axial and angular induction factors. • The optimal pitch angles were determined at off-design operating conditions. - Abstract: In this paper, a 200 kW horizontal axis wind turbine (HAWT) blade is designed using an efficient iterative algorithm based on the blade element momentum theory (BEM) on aerodynamic of wind turbines. The effects of off-design variations of wind speed are investigated on the blade performance parameters according to constant rotational speed of the rotor. The performance parameters considered are power coefficient, axial and angular induction factors, lift and drag coefficients on the blade, angle of attack and angle of relative wind. At higher or lower wind speeds than the designed rated speed, the power coefficient is reduced due to considerable changes in the angle of attacks. Therefore, proper pitch control angles were calculated to extract maximum possible power at various off-design speeds. The results showed a considerable improvement in power coefficient for the pitch controlled blade as compared with the baseline design in whole operating range. The present approach can be equally employed for determining pitch angles to design pitch control system of medium and large-scale wind turbines

A self-decoupling piezoresistive sensor for measuring microforce in horizontal and vertical directions

International Nuclear Information System (INIS)

Zhou, Jie; Rong, Weibin; Wang, Lefeng; Gao, Peng; Sun, Lining

2016-01-01

This paper presents the design, fabrication and calibration of a novel two-dimension microforce sensor with nano-Newton resolution. The sensor, mainly composed of a clamped–clamped beam (horizontal detecting beam), an overhanging beam (vertical detecting beam) and a half-folded beam, is highly sensitive to microforces in the horizontal (parallel to the probe of the designed sensor) and vertical (perpendicular to the wafer surface) directions. The four vertical sidewall surface piezoresistors (horizontal piezoresistors) and two surface piezoresistors (vertical piezoresistors) were fabricated to achieve the requirements of two-dimension microforce measurements. Combining the sensor structure with Wheatstone bridge configurations, the microforce decoupling among the x , y , and z direction can be realized. Accordingly, the sensor is capable of detecting microforces in the horizontal and vertical directions independently. The calibration results verified that the sensor sensitivities at room temperature are 210.58 V N −1 and 159.2 V N −1 in the horizontal and vertical directions, respectively. Additionally, the sensor’s corresponding force resolutions are estimated at 2 nN and 3 nN in theory, respectively. The sensor can be used to measure the contact force between manipulating tools and micro-objects, in fields such as microassembly and biological assays. (paper)

Verifying design patterns in Hoare Type Theory

DEFF Research Database (Denmark)

Svendsen, Kasper; Buisse, Alexandre; Birkedal, Lars

In this technical report we document our experiments formally verifying three design patterns in Hoare Type Theory.......In this technical report we document our experiments formally verifying three design patterns in Hoare Type Theory....

AN OUTLINE OF INTERACTION TYPES IN PHYSICAL SERIOUS GAMES

DEFF Research Database (Denmark)

Majgaard, Gunver

This poster explores a perspective in interaction design for physical serious games. It introduces a model for interaction types: horizontal, vertical and collaborative interaction at user level and developer's level. The thesis is that the richer and more meaningful the interaction is the better...

Analytic reconstruction algorithms for triple-source CT with horizontal data truncation

International Nuclear Information System (INIS)

Chen, Ming; Yu, Hengyong

2015-01-01

Purpose: This paper explores a triple-source imaging method with horizontal data truncation to enlarge the field of view (FOV) for big objects. Methods: The study is conducted by using theoretical analysis, mathematical deduction, and numerical simulations. The proposed algorithms are implemented in c + + and MATLAB. While the basic platform is constructed in MATLAB, the computationally intensive segments are coded in c + +, which are linked via a MEX interface. Results: A triple-source circular scanning configuration with horizontal data truncation is developed, where three pairs of x-ray sources and detectors are unevenly distributed on the same circle to cover the whole imaging object. For this triple-source configuration, a fan-beam filtered backprojection-type algorithm is derived for truncated full-scan projections without data rebinning. The algorithm is also extended for horizontally truncated half-scan projections and cone-beam projections in a Feldkamp-type framework. Using their method, the FOV is enlarged twofold to threefold to scan bigger objects with high speed and quality. The numerical simulation results confirm the correctness and effectiveness of the developed algorithms. Conclusions: The triple-source scanning configuration with horizontal data truncation cannot only keep most of the advantages of a traditional multisource system but also cover a larger FOV for big imaging objects. In addition, because the filtering is shift-invariant, the proposed algorithms are very fast and easily parallelized on graphic processing units

Improved design and durability of aluminum die casting horizontal shot sleeves

Science.gov (United States)

Birceanu, Sebastian

The design and performance of shot sleeves is critical in meeting the engineering requirements of aluminum die cast parts. Improvement in shot sleeve materials have a major impact on dimensional stability, reproducibility and quality of the product. This investigation was undertaken in order to improve the life of aluminum die casting horizontal shot sleeves. Preliminary pin tests were run to evaluate the soldering, wash-out and thermal fatigue behavior of commercially available materials and coatings. An experimental rig was designed and constructed for shot sleeve configuration evaluation. Fabrication and testing of experimental shot sleeves was based upon preliminary results and manufacturing costs. Three shot sleeve designs and materials were compared to a reference nitrided H13 sleeve. Nitrided H13 is the preferred material for aluminum die casting shot sleeves because of wear resistance, strength and relative good soldering and wash-out resistance. The study was directed towards damage evaluation on the area under the pouring hole. This area is the most susceptible to damage because of high temperatures and impingement of molten aluminum. The results of this study showed that tungsten and molybdenum had the least amount of soldering and wash-out damage, and the best thermal fatigue resistance. Low solubility in molten aluminum and stability of intermetallic layers are main factors that determine the soldering and wash-out behavior. Thermal conductivity and thermal expansion coefficient directly influence thermal fatigue behavior. TiAlN nanolayered coating was chosen as the material with the best damage resistance among several commercial PVD coatings, because of relatively large thickness and simple deposition conditions. The results show that molybdenum thermal sprayed coating provided the best protection against damage under the pouring hole. Improved bonding is however required for life extension of the coating. TiAlN PVD coating applied on H13 nitrided

Simulation of the Thermal Hydraulic Processes in the Horizontal Steam Generator with the Use of the Different Interfacial Friction Correlations

International Nuclear Information System (INIS)

Melikhov, V.; Melikhov, O.; Parfenov, Y.; Nerovnov, A.

2011-01-01

The horizontal steam generator (SG) is one of specific features of Russian-type pressurized water reactors (VVERs). The main advantages of horizontal steam generator are connected with low steam loads on evaporation surface, simple separation scheme and high circulation ratio. The complex three-dimensional steam-water flows in the steam generator vessel influence significantly the processes of the steam separation, distribution, and deposition of the soluble and non soluble impurities and determine the efficiency and reliability of the steam generator operation. The 3D code for simulation of the three-dimensional steam-water flows in the steam generator could be effective tool for design and optimization of the horizontal steam generator. The results of the code calculations are determined mainly by the set of the correlations describing interaction of the steam-water mixture with the inner constructions of the SG and interfacial friction. The results obtained by 3D code STEG with the usage of the different interfacial friction correlations are presented and discussed in the paper. These results are compared with the experimental ones obtained at the experimental test facility PGV-1500 constructed for investigation of the processes in the horizontal steam generator

Multivariate recurrence network analysis for characterizing horizontal oil-water two-phase flow.

Science.gov (United States)

Gao, Zhong-Ke; Zhang, Xin-Wang; Jin, Ning-De; Marwan, Norbert; Kurths, Jürgen

2013-09-01

Characterizing complex patterns arising from horizontal oil-water two-phase flows is a contemporary and challenging problem of paramount importance. We design a new multisector conductance sensor and systematically carry out horizontal oil-water two-phase flow experiments for measuring multivariate signals of different flow patterns. We then infer multivariate recurrence networks from these experimental data and investigate local cross-network properties for each constructed network. Our results demonstrate that a cross-clustering coefficient from a multivariate recurrence network is very sensitive to transitions among different flow patterns and recovers quantitative insights into the flow behavior underlying horizontal oil-water flows. These properties render multivariate recurrence networks particularly powerful for investigating a horizontal oil-water two-phase flow system and its complex interacting components from a network perspective.

Effect of Selection of Design Parameters on the Optimization of a Horizontal Axis Wind Turbine via Genetic Algorithm

International Nuclear Information System (INIS)

Alpman, Emre

2014-01-01

The effect of selecting the twist angle and chord length distributions on the wind turbine blade design was investigated by performing aerodynamic optimization of a two-bladed stall regulated horizontal axis wind turbine. Twist angle and chord length distributions were defined using Bezier curve using 3, 5, 7 and 9 control points uniformly distributed along the span. Optimizations performed using a micro-genetic algorithm with populations composed of 5, 10, 15, 20 individuals showed that, the number of control points clearly affected the outcome of the process; however the effects were different for different population sizes. The results also showed the superiority of micro-genetic algorithm over a standard genetic algorithm, for the selected population sizes. Optimizations were also performed using a macroevolutionary algorithm and the resulting best blade design was compared with that yielded by micro-genetic algorithm

Three-dimensional Frankfort horizontal plane for 3D cephalometry: a comparative assessment of conventional versus novel landmarks and horizontal planes.

Science.gov (United States)

Pittayapat, Pisha; Jacobs, Reinhilde; Bornstein, Michael M; Odri, Guillaume A; Lambrichts, Ivo; Willems, Guy; Politis, Constantinus; Olszewski, Raphael

2018-05-25

To assess the reproducibility of landmarks in three dimensions that determine the Frankfort horizontal plane (FH) as well as two new landmarks, and to evaluate the angular differences of newly introduced planes to the FH. Three-dimensional (3D) surface models were created from CBCT scans of 26 dry human skulls. Porion (Po), orbitale (Or), internal acoustic foramen (IAF), and zygomatico-maxillary suture (ZyMS) were indicated in the software by three observers twice with a 4-week interval. Angles between two FHs (FH 1: Or-R, Or-L, mid-Po; FH 2: Po-R, Po-L, mid-Or) and between FHs and new planes (Plane 1-6) were measured. Coordinates were exported to a spreadsheet. A statistical analysis was performed to define the landmark reproducibility and 3D angles. Intra- and inter-observer landmark reproducibility showed mean difference more than 1 mm for x-coordinates of all landmarks except IAF. IAF showed significantly better reproducibility than other landmarks (P Plane 3, connecting Or-R, Or-L and mid-IAF, and Plane 4, connecting Po-R, Po-L and mid-ZyMS, both showed an angular difference of less than 1 degree when compared to FHs. This study revealed poor reproducibility of the traditional FH landmarks on the x-axis and good reproducibility of a new landmark tested to replace Po, the IAF. Yet, Or showed superior results compared to ZyMS. The potential of using new horizontal planes was demonstrated. Future studies should focus on identification of a valid alternative for Or and ZyMS and on clinical implementation of the findings.

Newly discovered geological features and their potential impact on Darlington and Pickering

International Nuclear Information System (INIS)

Wallach, J.L.

1990-01-01

Newly available information reveals the presence of a prominent north-northeast oriented aeromagnetic lineament and east-northeast trending, linear patterns in young sediments on the bottom of Lake Ontario. The magnetic lineament, named the Niagara-Pickering Magnetic Lineament, passes practically beneath the Pickering Nuclear Generating Station (8x1600 MW reactors), and about 30 km west of the Darlington Nuclear Generating Station (4x2800 MW reactors). Magnetic data suggest that the Niagara-Pickering Magnetic Lineament may be the signature of a fault and may connect with the Akron Magnetic Boundary in Ohio, with which several earthquakes appear to be associated. Geological data lend support to the fault hypothesis. A north-northwest trending belt of earthquake epicenters, which includes the Lockport, NY earthquake (est M=5.0) and the Attica, NY earthquake (M=5.8), lies just east of, and parallels, the entire length of Georgian Bay en route to Attica, New York. The proximity and parallelism of the Georgian Bay Linear Zone to this belt of earthquake epicenters implies that the Georgian Bay Linear Zone may be tectonically active. The Georgian Bay Linear Zone and the Niagara-Pickering Magnetic Lineament appear to intersect very near Pickering and within about 30 km from Darlington. This, combined with evidence of high horizontal stresses in the area and the implication that both lineaments may be seismically active, suggests that many of the ingredients necessary for an earthquake of at least M=5.0 to M=6.25 exist near both Darlington and Pickering. Therefore, it is necessary that the Niagara-Pickering Magnetic Lineament, the Georgian Bay Linear Zone and the other newly discovered structural features be properly evaluated in order to determine whether or not the current Design Basis Seismic Ground Motions for Darlington and Pickering are adequate

Sample size requirements for studies of treatment effects on beta-cell function in newly diagnosed type 1 diabetes.

Science.gov (United States)

Lachin, John M; McGee, Paula L; Greenbaum, Carla J; Palmer, Jerry; Pescovitz, Mark D; Gottlieb, Peter; Skyler, Jay

2011-01-01

Preservation of β-cell function as measured by stimulated C-peptide has recently been accepted as a therapeutic target for subjects with newly diagnosed type 1 diabetes. In recently completed studies conducted by the Type 1 Diabetes Trial Network (TrialNet), repeated 2-hour Mixed Meal Tolerance Tests (MMTT) were obtained for up to 24 months from 156 subjects with up to 3 months duration of type 1 diabetes at the time of study enrollment. These data provide the information needed to more accurately determine the sample size needed for future studies of the effects of new agents on the 2-hour area under the curve (AUC) of the C-peptide values. The natural log(x), log(x+1) and square-root (√x) transformations of the AUC were assessed. In general, a transformation of the data is needed to better satisfy the normality assumptions for commonly used statistical tests. Statistical analysis of the raw and transformed data are provided to estimate the mean levels over time and the residual variation in untreated subjects that allow sample size calculations for future studies at either 12 or 24 months of follow-up and among children 8-12 years of age, adolescents (13-17 years) and adults (18+ years). The sample size needed to detect a given relative (percentage) difference with treatment versus control is greater at 24 months than at 12 months of follow-up, and differs among age categories. Owing to greater residual variation among those 13-17 years of age, a larger sample size is required for this age group. Methods are also described for assessment of sample size for mixtures of subjects among the age categories. Statistical expressions are presented for the presentation of analyses of log(x+1) and √x transformed values in terms of the original units of measurement (pmol/ml). Analyses using different transformations are described for the TrialNet study of masked anti-CD20 (rituximab) versus masked placebo. These results provide the information needed to accurately

Sample size requirements for studies of treatment effects on beta-cell function in newly diagnosed type 1 diabetes.

Directory of Open Access Journals (Sweden)

John M Lachin

Full Text Available Preservation of β-cell function as measured by stimulated C-peptide has recently been accepted as a therapeutic target for subjects with newly diagnosed type 1 diabetes. In recently completed studies conducted by the Type 1 Diabetes Trial Network (TrialNet, repeated 2-hour Mixed Meal Tolerance Tests (MMTT were obtained for up to 24 months from 156 subjects with up to 3 months duration of type 1 diabetes at the time of study enrollment. These data provide the information needed to more accurately determine the sample size needed for future studies of the effects of new agents on the 2-hour area under the curve (AUC of the C-peptide values. The natural log(x, log(x+1 and square-root (√x transformations of the AUC were assessed. In general, a transformation of the data is needed to better satisfy the normality assumptions for commonly used statistical tests. Statistical analysis of the raw and transformed data are provided to estimate the mean levels over time and the residual variation in untreated subjects that allow sample size calculations for future studies at either 12 or 24 months of follow-up and among children 8-12 years of age, adolescents (13-17 years and adults (18+ years. The sample size needed to detect a given relative (percentage difference with treatment versus control is greater at 24 months than at 12 months of follow-up, and differs among age categories. Owing to greater residual variation among those 13-17 years of age, a larger sample size is required for this age group. Methods are also described for assessment of sample size for mixtures of subjects among the age categories. Statistical expressions are presented for the presentation of analyses of log(x+1 and √x transformed values in terms of the original units of measurement (pmol/ml. Analyses using different transformations are described for the TrialNet study of masked anti-CD20 (rituximab versus masked placebo. These results provide the information needed to

Design and Synchronization of Master-Slave Electronic Horizontal Platform System

Directory of Open Access Journals (Sweden)

Hang-Hong Kuo

2012-01-01

Full Text Available Horizontal platform system (HPS is one of the mechanical systems with rich behavior and has extensively been applied in offshore and earthquake engineering. A corresponding electronic HPS is proposed in this paper to reduce the research cost and time when studying dynamics of the mechanical HPS. Furthermore, an output feedback controller is proposed for global synchronization between coupled electronic HPS systems and its stability condition is also derived by employing the Lyapunov stability theory. The experimental simulations verify the dynamics of the proposed electronic HPS and the synchronization effectiveness of the proposed control scheme.

Ethnicity and elevated liver transaminases among newly diagnosed children with type 2 diabetes

Directory of Open Access Journals (Sweden)

Hudson Omar D

2012-11-01

Full Text Available Abstract Background To examine the influence of ethnicity on liver transaminases among adolescents with type 2 diabetes mellitus (T2DM. Methods A retrospective medical chart review of 57 (30 males and 27 females newly diagnosed patients with T2DM. Ethnicity was determined by self-report and height, weight, body mass index (BMI and glycosylated hemoglobin (HbA1c were obtained using standard clinical procedures. Fasting levels of alanine aminotransaminase (ALT and aspartate aminotransferase (AST were collected prior to the initiation of any therapy. Results Age, gender, height, weight, BMI, and HbA1c did not differ between ethnic groups. Compared to African-Americans, Hispanics had significantly higher ALT (23.9 ± 3.4 vs. 107.8 ± 20.3, p=0.002 and AST (17.7 ± 2.5 vs. 71.1 ± 15.7, p Conclusions These preliminary findings suggest that Hispanic children with T2DM may be at higher risk for developing non-alcoholic fatty liver disease and indicate that a comprehensive hepatic evaluation is warranted in this population. Future studies that incorporate more precise and proximal measures of liver health are warranted in this population.

Composite Coiled Tubing for Extended Reach in Horizontal Oil Wells

DEFF Research Database (Denmark)

Costache, Andrei; Berggreen, Christian

2017-01-01

Conventional steel coiled tubing cannot reach along the entire length of very long horizontal oil wells. A lighter and more buoyant coiled tube is made possible using composite materials. The high stiffness to weight ratio of fiber reinforced polymers, coupled with a lower coefficient of friction......, has the potential of greatly extending the reach in horizontal oil wells. This study shows how to design composite coiled tubing and gives a comprehensive discussion about the most influential parameters. Several solutions, using glass-fiber and carbon are considered. Finite element models are used...

"I've made this my lifestyle now": a prospective qualitative study of motivation for lifestyle change among people with newly diagnosed type two diabetes mellitus.

Science.gov (United States)

Sebire, Simon J; Toumpakari, Zoi; Turner, Katrina M; Cooper, Ashley R; Page, Angie S; Malpass, Alice; Andrews, Robert C

2018-01-31

Diagnosis with Type 2 Diabetes is an opportunity for individuals to change their physical activity and dietary behaviours. Diabetes treatment guidelines recommend theory-based, patient-centred care and advocate the provision of support for patient motivation but the motivational experiences of people newly diagnosed with diabetes have not been well studied. Framed in self-determination theory, this study aimed to qualitatively explore how this patient group articulate and experience different types of motivation when attempting lifestyle change. A secondary analysis of semi-structured interview data collected with 30 (n female = 18, n male = 12) adults who had been newly diagnosed with type two diabetes and were participants in the Early ACTID trial was undertaken. Deductive directed content analysis was performed using NVivo V10 and researcher triangulation to identify and describe patient experiences and narratives that reflected the motivation types outlined in self-determination theory and if/how these changed over time. The findings revealed the diversity in motivation quality both between and within individuals over time and that patients with newly-diagnosed diabetes have multifaceted often competing motivations for lifestyle behaviour change. Applying self-determination theory, we identified that many participants reported relatively dominant controlled motivation to comply with lifestyle recommendations, avoid their non-compliance being "found out" or supress guilt following lapses in behaviour change attempts. Such narratives were accompanied by experiences of frustrating slow behaviour change progress. More autonomous motivation was expressed as something often achieved over time and reflected goals to improve health, quality of life or family time. Motivational internalisation was evident and some participants had integrated their behaviour change to a new way of life which they found resilient to common barriers. Motivation for lifestyle change

Improved waterflooding efficiency by horizontal wells

Energy Technology Data Exchange (ETDEWEB)

Popa, C. G. [Petroleum and Gas Univ., Ploesti (Romania); Clipea, M. [SNP Petrom SA, ICPT Campina (Romania)

1998-12-31

The influence of well pattern involving the use of horizontal wells on the overall efficiency of the waterflooding process was analyzed. Three different scenarios were examined: (1) a pattern of using two parallel horizontal wells, one for injection, the other for production, (2) a pattern of one horizontal well for water injection and several vertical wells for production, and (3) a pattern of using vertical wells for injection and one horizontal well for production. In each case, the waterflooding process was simulated using a two phase two dimensional numerical model. Results showed that the pressure loss along the horizontal section had a large influence on the sweep efficiency whether the horizontal well was used for injection or production. Overall, the most successful combination appeared to be using vertical wells for injection and horizontal wells for production. 4 refs., 1 tab., 15 figs.

Sea water desalination by horizontal tubes evaporator

International Nuclear Information System (INIS)

Mohammadi, H.K.; Mohit, M.

1986-01-01

Desalinated water supplies are one of the problems of the nuclear power plants located by the seas. This paper explains saline water desalination by a Horizontal Tube Evaporator (HTE) and compares it with flash evaporation. A thermo compressor research project using HTE method has been designed, constructed, and operated at the Esfahan Nuclear Technology Center ENTC. The poject's ultimate goal is to obtain empirical formulae based on data gathered during operation of the unit and its subsequent development towards design and construction of desalination plants on an industrial scale

Study on wave power generation of electricity using torsion arc blade type horizontal axis wind turbine; Nejire enko yokugata suihei jiku fusha wo mochiita haryoku hatsuden ni kansuru kenkyu

Energy Technology Data Exchange (ETDEWEB)

Kojima, N; Kishimura, K [Meiji University, Tokyo (Japan)

1996-10-27

Windmilling characteristics of a combination of a torsion arc blade type (TABT) horizontal axis wind turbine and a reverse torsion arc blade type (RTABT) horizontal axis wind turbine were evaluated in a wave activated power generation experiment. The TABT wind turbine had six blades, and the front and rear parts of the blade were twisted in the same direction, which caused the direction of rotor rotation to change as the direction of wind along the shaft changed. The RTABT wind turbine had twelve blades, and the front and rear parts of the blade were twisted reverse to each other, which allowed the direction of rotor rotation to stay constant even in the presence of wind direction reversal. To keep the direction of rotor rotation unchanged in the presence of flow direction reversal along the power generating turbine shaft, a single-stage type RTABT wind turbine and a double-stage type were used, the double-stage type being a series connection of a first-stage RTABT (for blowout and suction) and second-stage TABT (for blowout only). Both single-type and double-type rotated in the same direction irrespective of the direction of air flow. The output of the double type was obtained by adding up the values obtained from the individual turbines. The double type was two to three times higher in efficiency than the single type in turbine revolution and power output. 2 refs., 13 figs.

Lifestyle and clinical factors associated with elevated C-reactive protein among newly diagnosed Type 2 diabetes mellitus patients

DEFF Research Database (Denmark)

Svensson, Elisabeth; Mor, Anil; Rungby, Jørgen

2014-01-01

BACKGROUND: We aimed to examine the prevalence of and modifiable factors associated with elevated C-reactive Protein (CRP), a marker of inflammation, in men and women with newly diagnosed Type 2 Diabetes mellitus (DM) in a population-based setting. METHODS: CRP was measured in 1,037 patients (57...... was primarily elevated among patients with no regular physical activity (aRR 1.5 (95% CI 1.1-1.9)), previous cardiovascular disease (aRR1.5 (95% CI 1.2-1.9) and other comorbidity. For both genders, elevated CRP was 1.4-fold increased in those with weight gain >30 kg since age 20 years. Sensitivity analyses...

Verification of gamma knife based fractionated radiosurgery with newly developed head-thorax phantom

International Nuclear Information System (INIS)

Bisht, Raj Kishor; Kale, Shashank Sharad; Natanasabapathi, Gopishankar; Singh, Manmohan Jit; Agarwal, Deepak; Garg, Ajay; Rath, Goura Kishore; Julka, Pramod Kumar; Kumar, Pratik; Thulkar, Sanjay; Sharma, Bhawani Shankar

2016-01-01

Objective: Purpose of the study is to verify the Gamma Knife Extend™ system (ES) based fractionated stereotactic radiosurgery with newly developed head-thorax phantom. Methods: Phantoms are extensively used to measure radiation dose and verify treatment plan in radiotherapy. A human upper body shaped phantom with thorax was designed to simulate fractionated stereotactic radiosurgery using Extend™ system of Gamma Knife. The central component of the phantom aids in performing radiological precision test, dosimetric evaluation and treatment verification. A hollow right circular cylindrical space of diameter 7.0 cm was created at the centre of this component to place various dosimetric devices using suitable adaptors. The phantom is made of poly methyl methacrylate (PMMA), a transparent thermoplastic material. Two sets of disk assemblies were designed to place dosimetric films in (1) horizontal (xy) and (2) vertical (xz) planes. Specific cylindrical adaptors were designed to place thimble ionization chamber inside phantom for point dose recording along xz axis. EBT3 Gafchromic films were used to analyze and map radiation field. The focal precision test was performed using 4 mm collimator shot in phantom to check radiological accuracy of treatment. The phantom head position within the Extend™ frame was estimated using encoded aperture measurement of repositioning check tool (RCT). For treatment verification, the phantom with inserts for film and ion chamber was scanned in reference treatment position using X-ray computed tomography (CT) machine and acquired stereotactic images were transferred into Leksell Gammaplan (LGP). A patient treatment plan with hypo-fractionated regimen was delivered and identical fractions were compared using EBT3 films and in-house MATLAB codes. Results: RCT measurement showed an overall positional accuracy of 0.265 mm (range 0.223 mm–0.343 mm). Gamma index analysis across fractions exhibited close agreement between LGP and film

Effects of metformin on markers of oxidative stress and antioxidant reserve in patients with newly diagnosed type 2 diabetes: A randomized clinical trial

Directory of Open Access Journals (Sweden)

Yu V Pankratova

2012-09-01

Full Text Available Реферат по статье: Effects of metformin on markers of oxidative stress and antioxidant reserve in patients with newly diagnosed type 2 diabetes: A randomized clinical trial Alireza Esteghamati, Delaram Eskandari, Hossein Mirmiranpour, Sina Noshad, Mostafa Mousavizadeh, Mehdi Hedayati, Manouchehr Nakhjavan//Clinical Nutrition xxx (2012 1-7 Tehran, Iran

Detecting Horizontal Gene Transfer between Closely Related Taxa.

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Orit Adato

2015-10-01

Full Text Available Horizontal gene transfer (HGT, the transfer of genetic material between organisms, is crucial for genetic innovation and the evolution of genome architecture. Existing HGT detection algorithms rely on a strong phylogenetic signal distinguishing the transferred sequence from ancestral (vertically derived genes in its recipient genome. Detecting HGT between closely related species or strains is challenging, as the phylogenetic signal is usually weak and the nucleotide composition is normally nearly identical. Nevertheless, there is a great importance in detecting HGT between congeneric species or strains, especially in clinical microbiology, where understanding the emergence of new virulent and drug-resistant strains is crucial, and often time-sensitive. We developed a novel, self-contained technique named Near HGT, based on the synteny index, to measure the divergence of a gene from its native genomic environment and used it to identify candidate HGT events between closely related strains. The method confirms candidate transferred genes based on the constant relative mutability (CRM. Using CRM, the algorithm assigns a confidence score based on "unusual" sequence divergence. A gene exhibiting exceptional deviations according to both synteny and mutability criteria, is considered a validated HGT product. We first employed the technique to a set of three E. coli strains and detected several highly probable horizontally acquired genes. We then compared the method to existing HGT detection tools using a larger strain data set. When combined with additional approaches our new algorithm provides richer picture and brings us closer to the goal of detecting all newly acquired genes in a particular strain.

Patients newly diagnosed with clinical type 2 diabetes mellitus but presenting with HbA1c within normal range: 19-year mortality and clinical outcomes

DEFF Research Database (Denmark)

Veloso, A.G.; Siersma, V.; Heldgaard, P.E.

2013-01-01

AIMS: To investigate whether long-term mortality or clinical outcomes differed between patients diagnosed with type 2 diabetes mellitus and presenting with HbA1c within or above normal range at time of diagnosis. METHODS: Data were from a population-based sample of 1136 individuals with newly dia...

Eliminating Glutamatergic Input onto Horizontal Cells Changes the Dynamic Range and Receptive Field Organization of Mouse Retinal Ganglion Cells.

Science.gov (United States)

Ströh, Sebastian; Puller, Christian; Swirski, Sebastian; Hölzel, Maj-Britt; van der Linde, Lea I S; Segelken, Jasmin; Schultz, Konrad; Block, Christoph; Monyer, Hannah; Willecke, Klaus; Weiler, Reto; Greschner, Martin; Janssen-Bienhold, Ulrike; Dedek, Karin

2018-02-21

responses of transient OFF-α retinal ganglion cells in a newly generated mouse line. In this mouse line, horizontal cell signals were no longer modulated by light. With light response recordings, we show that horizontal cells increase the dynamic range of retinal ganglion cells for contrast and temporal changes and contribute to the center/surround organization of their receptive fields. Copyright © 2018 the authors 0270-6474/18/382015-14$15.00/0.

Insulin requirement profiles of short-term intensive insulin therapy in patients with newly diagnosed type 2 diabetes and its association with long-term glycemic remission.

Science.gov (United States)

Liu, Liehua; Ke, Weijian; Wan, Xuesi; Zhang, Pengyuan; Cao, Xiaopei; Deng, Wanping; Li, Yanbing

2015-05-01

To investigate the insulin requirement profiles during short-term intensive continuous subcutaneous insulin infusion (CSII) in patients with newly diagnosed type 2 diabetes and its relationship with long-term glycemic remission. CSII was applied in 104 patients with newly diagnosed type 2 diabetes. Daily insulin doses were titrated and recorded to achieve and maintain euglycemia for 2 weeks. Measurements of blood glucose, lipid profiles as well as intravenous glucose tolerance tests were performed before and after the therapy. Afterwards, patients were followed up for 1 year. Total daily insulin dose (TDD) was 56.6±16.1IU at the first day when euglycemia was achieved (TDD-1). Thereafter, TDD progressively decreased at a rate of 1.4±1.0IU/day to 36.2±16.5IU at the end of the therapy. TDD-1 could be estimated with body weight, FPG, triglyceride and waist circumference in a multiple linear regression model. Decrement of TDD after euglycemia was achieved (ΔTDD) was associated with reduction of HOMA-IR (r=0.27, P=0.008) but not with improvement in β cell function. Patients in the lower tertile of ΔTDD had a significantly higher risk of hyperglycemia relapse than those in the upper tertile within 1 year (HR 3.4, 95%CI [1.4, 8.4], P=0.008). There is a steady decline of TDD after euglycemia is achieved in patients with newly diagnosed type 2 diabetes treated with CSII, and ΔTDD is associated with a better long-term glycemic outcome. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Inverse Association of Plasma Chromium Levels with Newly Diagnosed Type 2 Diabetes: A Case-Control Study

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Sijing Chen

2017-03-01

Full Text Available Chromium has long been known as an enhancer of insulin action. However, the role of chromium in the development of type 2 diabetes mellitus (T2DM in humans remains controversial. The current study aimed to examine the associations of plasma chromium levels with T2DM and pre-diabetes mellitus (pre-DM. We conducted a case-control study involving 1471 patients with newly diagnosed T2DM, 682 individuals with newly diagnosed pre-DM, and 2290 individuals with normal glucose tolerance in a Chinese population from 2009 to 2014. Plasma chromium was measured by inductively coupled plasma mass spectrometry. Plasma chromium levels were lower in the T2DM and pre-DM groups than in the control group (median: 3.68 μg/L, 3.61 μg/L, 3.97 μg/L, respectively, p < 0.001. After adjustment for potential confounding factors, the odds ratios (95% confidence interval for T2DM across increasing quartiles of plasma chromium levels were 1 (referent, 0.67 (0.55–0.83, 0.64 (0.51–0.79, and 0.58 (0.46–0.73, respectively (p for trend <0.001. The corresponding odds ratios (95% confidence interval for pre-DM were 1 (referent, 0.70 (0.54–0.91, 0.67 (0.52–0.88, and 0.58 (0.43–0.78, respectively (p for trend < 0.001. Our results indicated that plasma chromium concentrations were inversely associated with T2DM and pre-DM in Chinese adults.

Efficiency of a Horizontal Sub-Surface Flow Constructed Wetland Treatment System in an Arid Area

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Abeer Albalawneh

2016-02-01

Full Text Available The main objective of this study was to evaluate the performance and treatment efficiency of the Horizontal Sub-Surface Flow Constructed Wetland treatment system (HSF-CW in an arid climate. Seventeen sub-surface, horizontal-flow HSF-CW units have been operated for approximately three years to improve the quality of partially-treated municipal wastewater. The studied design parameters included two sizes of volcanic tuff media (i.e., fine or coarse, two different bed dimensions (i.e., long and short, and three plantation types (i.e., reed, kenaf, or no vegetation as a control. The effluent Biological Oxygen Demand (BOD5, Chemical Oxygen Demand (COD, Total Suspended Solid (TSS, and phosphorus from all of the treatments were significantly lower as compared to the influent and demonstrated a removal efficiency of 55%, 51%, 67%, and 55%, respectively. There were significant increases in Electrical Conductivity (EC, sulfate, and calcium in the effluent of most HSF-CWs due to evaporative concentration and mineral dissolution from the media. The study suggests that unplanted beds with either fine or coarse media are the most suitable combinations among all of the studied designs based on their treatment efficiency and less water loss in arid conditions.

Improved design and in-situ measurements of new beam position monitors for Indus-2

Science.gov (United States)

Kumar, M.; Babbar, L. K.; Holikatti, A. C.; Yadav, S.; Tyagi, Y.; Puntambekar, T. A.; Senecha, V. K.

2018-01-01

Beam position monitors (BPM) are important diagnostic devices used in particle accelerators to monitor position of the beam for various applications. Improved version of button electrode BPM has been designed using CST Studio Suite for Indus-2 ring. The new BPMs are designed to replace old BPMs which were designed and installed more than 12 years back. The improved BPMs have higher transfer impedance, resonance free output signal, equal sensitivity in horizontal and vertical planes and fast decaying wakefield as compared to old BPMs. The new BPMs have been calibrated using coaxial wire method. Measurement of transfer impedance and time domain signals has also been performed in-situ with electron beam during Indus-2 operation. The calibration and beam based measurements results showed close agreement with the design parameters. This paper presents design, electromagnetic simulations, calibration result and in-situ beam based measurements of newly designed BPMs.

Prevalence and progression of visual impairment in patients newly diagnosed with clinical type 2 diabetes: a 6-year follow up study

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Almind Gitte

2011-02-01

Full Text Available Abstract Background Many diabetic patients fear visual loss as the worst consequence of diabetes. In most studies the main eye pathology is assigned as the cause of visual impairment. This study analysed a broad range of possible ocular and non-ocular predictors of visual impairment prospectively in patients newly diagnosed with clinical type 2 diabetes. Methods Data were from a population-based cohort of 1,241 persons newly diagnosed with clinical, often symptomatic type 2 diabetes aged ≥ 40 years. After 6 years, 807 patients were followed up. Standard eye examinations were done by practising ophthalmologists. Results At diabetes diagnosis median age was 65.5 years. Over 6 years, the prevalence of blindness (visual acuity of best seeing eye ≤ 0.1 rose from 0.9% (11/1,241 to 2.4% (19/807 and the prevalence of moderate visual impairment (> 0.1; Conclusions In a comprehensive assessment of predictors of visual impairment, even in a health care system allowing self-referral to free eye examinations, treatable eye pathologies such as DR and cataract emerge together with age as the most notable predictors of continued visual loss after diabetes diagnosis. Our results underline the importance of eliminating barriers to efficient eye care by increasing patients' and primary care practitioners' awareness of the necessity of regular eye examinations and timely surgical treatment.

Expansion mechanisms for indigenously developed horizontal honing machines (Paper No. 06)

International Nuclear Information System (INIS)

Murthy, G.S.K.; Devarajan, N.

1987-02-01

Coolant channel components for nuclear reactors require scratch free and smooth interior surfaces in addition to control on size. This calls for finish machining by honing process. At the time when these were required to be made, there were no manufacturers in India who were making honing machines especially of horizontal type. In order to meet this requirement, Central Workshops of Bhabha Atomic Research Centre developed and manufactured two horizontal honing machines which can handle tubes upto three metres in length. One of the machines has been so made to accommodate jobs upto six metres in length. Stone expansion mechanisms used in these machines were of automatic hydraulic type combined with a mechanical expansion device. Details of these mechanisms have been discussed in this paper. (author). 3 figs

Multidisciplinary Design Optimization for Glass-Fiber Epoxy-Matrix Composite 5 MW Horizontal-Axis Wind-Turbine Blades

Science.gov (United States)

Grujicic, M.; Arakere, G.; Pandurangan, B.; Sellappan, V.; Vallejo, A.; Ozen, M.

2010-11-01

A multi-disciplinary design-optimization procedure has been introduced and used for the development of cost-effective glass-fiber reinforced epoxy-matrix composite 5 MW horizontal-axis wind-turbine (HAWT) blades. The turbine-blade cost-effectiveness has been defined using the cost of energy (CoE), i.e., a ratio of the three-blade HAWT rotor development/fabrication cost and the associated annual energy production. To assess the annual energy production as a function of the blade design and operating conditions, an aerodynamics-based computational analysis had to be employed. As far as the turbine blade cost is concerned, it is assessed for a given aerodynamic design by separately computing the blade mass and the associated blade-mass/size-dependent production cost. For each aerodynamic design analyzed, a structural finite element-based and a post-processing life-cycle assessment analyses were employed in order to determine a minimal blade mass which ensures that the functional requirements pertaining to the quasi-static strength of the blade, fatigue-controlled blade durability and blade stiffness are satisfied. To determine the turbine-blade production cost (for the currently prevailing fabrication process, the wet lay-up) available data regarding the industry manufacturing experience were combined with the attendant blade mass, surface area, and the duration of the assumed production run. The work clearly revealed the challenges associated with simultaneously satisfying the strength, durability and stiffness requirements while maintaining a high level of wind-energy capture efficiency and a lower production cost.

Horizontal drilling assessment in Western Canada

International Nuclear Information System (INIS)

Catania, Peter; Wilson, Malcolm

1999-01-01

The first horizontal well was drilled in Saskatchewan in 1987. Since then, the number of horizontal wells drilled has escalated rapidly, averaging approximately 500 per year since 1993. When combined with horizontal wells drilled in Alberta, the major Canadian oil-producing province, the total number drilled in 1995 was 978. This total exceeds the National Energy Board (NEB) projected maximum of 816 wells per year. The NEB projections were based on a break-even point for the drilling of horizontal wells of a return of CDN $285,000 using a discount rate of 15%. This corresponded to a cumulative production from each individual well of some 11,000 m 3 . The introduction of a royalty-free production volume of 12,000 m 3 per horizontal well in Saskatchewan was instrumental in stimulating the rapid expansion in the use of horizontal wells and helping Canada to exceed the forecasted drilling level. Within Saskatchewan, daily production from 1964 active horizontal wells is in excess of 20,000 m 3 . Comparative analysis indicates that the average daily production per well has increased from approximately by 40% with the advent of horizontal wells. In total production terms, provincial production has increased from 11.7 million cubic metres in 1989 to 20.9 million m 3 in 1996. This represents an increase of almost 79% based primarily on the extensive use of horizontal wells. In 1996, horizontal wells produced 36% of the province's oil from 12% of the active wells. In the southeastern producing areas of Saskatchewan, the Williston Basin, declining oil-production has jumped 100%, with horizontal wells accounting for approximately 50% of total regional production. Pay zones in this areas, as in most of the province, tend to be relatively thin, with net pay frequently less that 5 m. The modest investment of some CDN $5 million in government research funding 10 years ago to stimulate the development of horizontal wells, combined with a favourable royalty structure, has been at

Horizontal Axis Wind Turbine Blade Design Methodologies for Efficiency Enhancement—A Review

Directory of Open Access Journals (Sweden)

Shafiqur Rehman

2018-02-01

Full Text Available Among renewable sources of energy, wind is the most widely used resource due to its commercial acceptance, low cost and ease of operation and maintenance, relatively much less time for its realization from concept till operation, creation of new jobs, and least adverse effect on the environment. The fast technological development in the wind industry and availability of multi megawatt sized horizontal axis wind turbines has further led the promotion of wind power utilization globally. It is a well-known fact that the wind speed increases with height and hence the energy output. However, one cannot go above a certain height due to structural and other issues. Hence other attempts need to be made to increase the efficiency of the wind turbines, maintaining the hub heights to acceptable and controllable limits. The efficiency of the wind turbines or the energy output can be increased by reducing the cut-in-speed and/or the rated-speed by modifying and redesigning the blades. The problem is tackled by identifying the optimization parameters such as annual energy yield, power coefficient, energy cost, blade mass, and blade design constraints such as physical, geometric, and aerodynamic. The present paper provides an overview of the commonly used models, techniques, tools and experimental approaches applied to increase the efficiency of the wind turbines. In the present review work, particular emphasis is made on approaches used to design wind turbine blades both experimental and numerical, methodologies used to study the performance of wind turbines both experimentally and analytically, active and passive techniques used to enhance the power output from wind turbines, reduction in cut-in-speed for improved wind turbine performance, and lastly the research and development work related to new and efficient materials for the wind turbines.

Association of depression with newly diagnosed type 2 diabetes among adults aged between 25 to 60 years in Karachi, Pakistan

Directory of Open Access Journals (Sweden)

Perveen Shazia

2010-03-01

Full Text Available Abstract Background The combination of depression with type 2 diabetes is a public health problem. If diabetes is managed in its initial phase, the morbidity and mortality due to this combination may be prevented at an early stage. Therefore, we aimed to determine the association of depression with newly diagnosed type 2 diabetes among adults aged between 25 to 60 years in Karachi, Pakistan. Methods From July 2006 to September 2007, a matched case control study (n = 592 was conducted in Civil Hospital, Karachi. Incident cases of type 2 diabetes (n = 296 diagnosed within one month were recruited from diabetic Out Patient Department (OPD of Civil Hospital, Karachi. They were matched on age and sex with controls (n = 296, who were attendants sitting in the medical out patient department of the same hospital, recruited on the basis of absence of classical symptoms of polyuria and polydispia along with random blood glucose level of Results The study comprised of 592 subjects with 432(73% males and 160(27% females. Depression was significantly associated with newly diagnosed type 2 diabetes having mild level (mOR: 3.86; 95%CI: 2.22,6.71 and moderate to severe level (mOR: 3.41; 95%CI: 2.07,5.61. History of (h/o gestational diabetes (mOR: 2.83; 95%CI: 1.05,7.64, family h/o diabetes (mOR: 1.59; 95%CI: 1.04,2.43, nuclear family (mOR: 1.75; 95%CI: 1.14,2.69, BMI (mOR: 1.62; 95%CI: 1.01,2.60 for obese and mOR: 2.12; 95%CI: 1.19,3.79 for overweight vs healthy to underweight were also significantly associated with outcome, adjusting for age, sex, marital status, h/o smoking and h/o high BP. Conclusions Diabetics should be screened simultaneously for depression and concomitant preventive strategies for gestational diabetes, nuclear family and high BMI should also be used to prevent mortality/morbidity among patients between 25 to 60 years of age.

Blade root design a state of the art survey

Energy Technology Data Exchange (ETDEWEB)

Sandberg, O

1988-06-01

This report was conceived in the wake of recent blade root failures in several horizontal axis turbines. Ten blade root designs are presented. They are considered to represent the state of the art. The information was obtained partly from literature partly from a few important projects with little or no documentation. Suggestions are made how to proceed in the development of the bonded bolt type of root retention. Presently the conclusion is that this type of arrangement seems the most promising. Developments in this field should be closely monitored, however. For this type of very high cycle fatigue designs there is a need for two redundant design principles. (author).

A newly designed 45 to 60 mer oligonucleotide Agilent platform microarray for global gene expression studies of Synechocystis PCC6803: example salt stress experiment

NARCIS (Netherlands)

Aguirre von Wobeser, E.; Huisman, J.; Ibelings, B.; Matthijs, H.C.P.; Matthijs, H.C.P.

2005-01-01

A newly designed 45 to 60 mer oligonucleotide Agilent platform microarray for global gene expression studies of Synechocystis PCC6803: example salt stress experiment Eneas Aguirre-von-Wobeser 1, Jef Huisman1, Bas Ibelings2 and Hans C.P. Matthijs1 1 Universiteit van Amsterdam, Amsterdam, The

Prediction of Heat Removal Capacity of Horizontal Condensation Heat Exchanger submerged in Pool

Energy Technology Data Exchange (ETDEWEB)

Jeon, Seong-Su; Hong, Soon-Joon [FNC Tech., Yongin (Korea, Republic of); Cho, Hyoung-Kyu [Seoul National University, Seoul (Korea, Republic of); Park, Goon-Cherl [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

2014-10-15

As representative passive safety systems, there are the passive containment cooling system (PCCS) of ESBWR, the emergency condenser system (ECS) of the SWR-1000, the passive auxiliary feed-water system (PAFS) of the APR+ and etc. During the nuclear power plant accidents, these passive safety systems can cool the nuclear system effectively via the heat transfer through the steam condensation, and then mitigate the accidents. For the optimum design and the safety analysis of the passive safety system, it is essential to predict the heat removal capacity of the heat exchanger well. The heat removal capacity of the horizontal condensation heat exchanger submerged in a pool is determined by a combination of a horizontal in-tube condensation heat transfer and a boiling heat transfer on the horizontal tube. Since most correlations proposed in the previous nuclear engineering field were developed for the vertical tube, there is a certain limit to apply these correlations to the horizontal tube. Therefore, this study developed the heat transfer model for the horizontal Ushaped condensation heat exchanger submerged in a pool to predict well the horizontal in-tube condensation heat transfer, the boiling heat transfer on the horizontal tube and the overall heat removal capacity of the heat exchanger using the best-estimate system analysis code, MARS.

Insulin autoantibodies: evidence of autoimmune disease among a group of Puerto Rican children with newly diagnosed type 1 diabetes mellitus.

Science.gov (United States)

González de Pijem, L; Nieves-Rivera, F

2001-06-01

Type 1 diabetes is a chronic disease caused by a cell-specific destruction of the insulin producing cells of the pancreas. Although Puerto Rico has the highest incidence of type 1 diabetes among Latin American countries, there is scanty data on the presence of antibodies against insulin producing cells. To this end, 20 children (8 males, 12 females), ages 1-15 years, admitted to the University Pediatric Hospital with type 1 diabetes de novo between November 2000 and April 2001 were prospectively studied to determine the presence of serum antibodies against Islet cells (ICA), glutamic acid decarboxylase (GAD-65) and insulin autoantibodies (IAA). IAA was found to be present in 45% of the subjects with 85% of positive rate in subjects under age 5. GAD-65 was present in 66% and ICA was present in 23% of the subjects. We found evidence of autoimmunity against islet cell surface and intracellular components among a cohort of Puerto Rican children with newly diagnosed type 1 diabetes. These findings compared favorably with reports from other ethnicities.

Experimental on two sensors combination used in horizontal pipe gas-water two-phase flow

International Nuclear Information System (INIS)

Wu, Hao; Dong, Feng

2014-01-01

Gas-water two phase flow phenomenon widely exists in production and living and the measurement of it is meaningful. A new type of long-waist cone flow sensor has been designed to measure two-phase mass flow rate. Six rings structure of conductance probe is used to measure volume fraction and axial velocity. The calibration of them have been made. Two sensors have been combined in horizontal pipeline experiment to measure two-phase flow mass flow rate. Several model of gas-water two-phase flow has been discussed. The calculation errors of total mass flow rate measurement is less than 5% based on the revised homogeneous flow model

Statistical studies of vertical and horizontal earthquake spectra

Energy Technology Data Exchange (ETDEWEB)

Hall, W.J.; Mohraz, B.; Newmark, N.M.

1976-01-01

The study reveals that there is no well-defined dependence of normalized seismic design response spectra on the earthquake ground acceleration level. Recommendations for horizontal design response spectra are close to those given in Regulatory Guide 1.60. Recommendations for vertical response spectra are somewhat lower than Regulatory Guide 1.60 provisions in the frequency range 2 to 30 Hz aproximately. The results are based on seismic information recorded along the west coast of the United States and are directly applicable to that region only.

[Principles of nutrition in patients with newly appointed stoma].

Science.gov (United States)

Pachocka, Lucyna Małgorzata; Urbanik, Anna

2016-01-01

The treatment of intestinal stoma is often a difficult experience for patients and results in numerous problems in the physical, psychological and social aspects. Therefore, post-operative care of the patient with the newly appointed stoma should be taken by therapeutic team consisting of doctors, nurses, physiotherapists, dieticians, psychologists and social workers. Appropriate nutritional education of patients aims to improve their quality of life and to prevent from unpleasant ailments formed after the operation. The specific type of stoma may decide about certain dietary recommendations. The presented work provides a practical dietary recommendations for patients with newly appointed stoma.

Newly velocity field of Sulawesi Island from GPS observation

Science.gov (United States)

Sarsito, D. A.; Susilo, Simons, W. J. F.; Abidin, H. Z.; Sapiie, B.; Triyoso, W.; Andreas, H.

2017-07-01

Sulawesi microplate Island is located at famous triple junction area of the Eurasian, India-Australian, and Philippine Sea plates. Under the influence of the northward moving Australian plate and the westward motion of the Philippine plate, the island at Eastern part of Indonesia is collide and with the Eurasian plate and Sunda Block. Those recent microplate tectonic motions can be quantitatively determine by GNSS-GPS measurement. We use combine GNSS-GPS observation types (campaign type and continuous type) from 1997 to 2015 to derive newly velocity field of the area. Several strategies are applied and tested to get the optimum result, and finally we choose regional strategy to reduce error propagation contribution from global multi baseline processing using GAMIT/GLOBK 10.5. Velocity field are analyzed in global reference frame ITRF 2008 and local reference frame by fixing with respect alternatively to Eurasian plate - Sunda block, India-Australian plate and Philippine Sea plates. Newly results show dense distribution of velocity field. This information is useful for tectonic deformation studying in geospatial era.

Isolation, Genome Phylogenetic Analysis and In vitro Rescue of a Newly Emerging Porcine Circovirus Type 2

Directory of Open Access Journals (Sweden)

Weijuan Zhu and Xiaofeng Ren*

2012-05-01

Full Text Available Porcine circovirus type 2 (PCV2 is the major causative agent of post-weaning multisystemic wasting syndrome (PMWS. Infection by PCV2 may cause heavy losses in pig industry. In this study, we report the isolation of a newly emerging PCV2 from northeastern China. The complete genome of the PCV2 isolate named PCV2-LJR contains 1766 nucleotides and was compared with reference sequences published in GenBank followed by topology analysis of the resulting phylogenetic tree. The data indicated that the prevalent PCV2 isolates in the northeastern China had close relationship, although various genotypes of PCV2 existed. In addition, by gene recombination and transfection techniques, the PCV2 infectious clone was achieved and was able to rescue virus in vitro determined by indirect immunofluorescence assay and PCR. The obtained biological materials may be used for biological characterization of PCV2.

The use of horizontal wells for subsurface soil and aquifer remediation

International Nuclear Information System (INIS)

May, D.W.

1994-01-01

The use of directionally controlled horizontal drilling for environmental restoration had its genesis in 1988 when two horizontal remediation wells were drilled at the Savannah River Nuclear Facility near Aiken, South Carolina. Since that time, horizontal remediation wells have been drilled at several Department of Energy and Department of Defense sites as well as on several commercial sites across the country. Directional drilling technology applied to ''Near Surface Horizontal Environmental Drilling'' comes from the oil and gas industry, the utility/pipeline river crossing industry and to a lesser extent the mining industry. Rig designs vary from very small track or wheel mounted rigs using 10 feet (3 meters) drill pipe and having less than 2,500 ft. lb. (3,400 N-m) of torque and 15,000 lb. (67 kN) of push/pull force to extremely large trailer mounted rigs with torques exceeding 60,000 ft. lb. (81,400 N-m) and over 500,000 lb. (2,200 kN) of pull. Vertical depths of horizontal wells drilled to-date have exceeded 250 feet (75 m), but the great majority of contaminant plumes are located at depths of less than 50 feet (15 m). Horizontal well displacements have exceeded 1000 feet (300 m) but most of the projects cover less than 400 feet (120 m). Wells can be drilled ''blind'' (terminate in the earth) or exit back up the earth on the other side of the plume from the drill rig

A newly designed multichannel scaling system: Validated by Feynman-α experiment in EHWZPR

Energy Technology Data Exchange (ETDEWEB)

Arkani, Mohammad, E-mail: markani@aeoi.org.ir; Mataji-Kojouri, Naimeddin

2016-08-15

Highlights: • An embedded measuring system with enhanced operational capabilities is introduced to the scientists. • The design is low cost and reprogrammable. • The system design is dedicated to multi-detector experiments with huge data collection. • Non count loss effect Feynman-α experiment is performed in EHWZPR. • The results is compared with endogenous/inherent pulsed neutron source experiment. - Abstract: In this work, an embedded multi-input multi-million-channel MCS in a newly design is constructed for multi-detector experimental research applications. Important characteristics of the system are possible to be tuned based on experimental case studies utilizing the reprogrammable nature of the silicon. By means of differentiation of the integrated counts registered in memory, this system is featured as a zero channel advance time measuring tool ideal for experiments on time correlated random processes. Using this equipment, Feynman-α experiment is performed in Esfahan Heavy Water Zero Power Reactor (EHWZPR) utilizing three different in-core neutron detectors. One million channel data is collected by the system in 5 ms gate time from each neutron detector simultaneously. As heavy water moderated reactors are significantly slow systems, a huge number of data channels is required to be collected. Then, by making in use of bunching method, the data is analyzed and prompt neutron decay constant of the system is estimated for each neutron detector positioned in the core. The results are compared with the information provided by endogenous pulsed neutron source experiment and a good agreement is seen within the statistical uncertainties of the results. This equipment makes further research in depth possible in a range of stochastic experiments in nuclear physics such as cross correlation analysis of multi-detector experiments.

In situ detection of horizontal transfer of mobile genetic elements

DEFF Research Database (Denmark)

Haagensen, Janus Anders Juul; Hansen, Susse Kirkelund; Johansen, Tove

2002-01-01

. The obtained data show that the several different types of fluorescent reporters, which are now available, allow more informative in situ investigations of horizontal gene transfer to be carried out, and by combining these genes with various expression systems it is possible to simultaneously monitor donor...

Horizontal transfers of Mariner transposons between mammals and insects.

Science.gov (United States)

Oliveira, Sarah G; Bao, Weidong; Martins, Cesar; Jurka, Jerzy

2012-09-26

Active transposable elements (TEs) can be passed between genomes of different species by horizontal transfer (HT). This may help them to avoid vertical extinction due to elimination by natural selection or silencing. HT is relatively frequent within eukaryotic taxa, but rare between distant species. Closely related Mariner-type DNA transposon families, collectively named as Mariner-1_Tbel families, are present in the genomes of two ants and two mammalian genomes. Consensus sequences of the four families show pairwise identities greater than 95%. In addition, mammalian Mariner1_BT family shows a close evolutionary relationship with some insect Mariner families. Mammalian Mariner1_BT type sequences are present only in species from three groups including ruminants, tooth whales (Odontoceti), and New World leaf-nosed bats (Phyllostomidae). Horizontal transfer accounts for the presence of Mariner_Tbel and Mariner1_BT families in mammals. Mariner_Tbel family was introduced into hedgehog and tree shrew genomes approximately 100 to 69 million years ago (MYA). Most likely, these TE families were transferred from insects to mammals, but details of the transfer remain unknown.

Heat transfer by natural convection into an horizontal cavity

International Nuclear Information System (INIS)

Arevalo J, P.

1998-01-01

At this thesis it is studied the heat transfer by natural convection in an horizontal cavity, it is involved a boiling's part that is described the regimes and correlations differences for boiling's curve. It is designed a horizontal cavity for realize the experimental part and it's mention from equipment or instrumentation to succeed in a experimentation that permits to realize the analysis of heat transfer, handling as water fluid at atmospheric pressure and where it's present process from natural convection involving part boiling's subcooled. The system consists of heater zone submerged in a horizontal cavity with water. Once part finished experimental with information to obtained it's proceeded to obtain a correlation, realized starting from analysis dimensionless such as: Jakob, Bond and Grasoft (Boiling) besides of knows in natural convection: Prandtl and Nusselt. The mathematical model explains the behavior for natural convection continued part boiling's subcooled. It is realize analysis graphics too where it's show comparing with Globe Dropkin and Catton equations by natural convection with bottom heating. (Author)

Seismic behavior of a low-rise horizontal cylindrical tank

Science.gov (United States)

Fiore, Alessandra; Rago, Carlo; Vanzi, Ivo; Greco, Rita; Briseghella, Bruno

2018-05-01

Cylindrical storage tanks are widely used for various types of liquids, including hazardous contents, thus requiring suitable and careful design for seismic actions. The study herein presented deals with the dynamic analysis of a ground-based horizontal cylindrical tank containing butane and with its safety verification. The analyses are based on a detailed finite element (FE) model; a simplified one-degree-of-freedom idealization is also set up and used for verification of the FE results. Particular attention is paid to sloshing and asynchronous seismic input effects. Sloshing effects are investigated according to the current literature state of the art. An efficient methodology based on an "impulsive-convective" decomposition of the container-fluid motion is adopted for the calculation of the seismic force. The effects of asynchronous ground motion are studied by suitable pseudo-static analyses. Comparison between seismic action effects, obtained with and without consideration of sloshing and asynchronous seismic input, shows a rather important influence of these conditions on the final results.

Association between age, IL-10, IFN¿, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

DEFF Research Database (Denmark)

Kaas, A; Pfleger, Claudia Christina; Kharagjitsingh, A V

2012-01-01

Aims: The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFN¿) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes. Methods: Two hundred and twenty-seven patients from the Hvidoere Study Group were...... classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFN¿ gene were genotyped and serum levels of IL-10 and IFN¿ were measured at 1, 6 and 12 months. Results: IL-10 decreased (P...

Horizontal Accelerator

Data.gov (United States)

Federal Laboratory Consortium — The Horizontal Accelerator (HA) Facility is a versatile research tool available for use on projects requiring simulation of the crash environment. The HA Facility is...

A review on critical heat flux in horizontal tubes

International Nuclear Information System (INIS)

Baburajan, P.K.; Gaikwad, Avinash; Prabhu, S.V.

2015-01-01

Coolant channels of PHWR during accident similar to loss of coolant accident (LOCA) may experience different flow transients with low pressure and low flow conditions. In the advanced PHWRs it is desired to have small amount of positive quality at the exit of the coolant channel to increase the thermal efficiency. Investigation on pressure drop and heat transfer coefficient under subcooled boiling condition is important in the design and operation of the PHWRs. Understanding of thermal hydraulic phenomena associated with horizontal flow is also important in the safety and accident management in these reactors. A detailed experimental investigation on the important thermal hydraulic phenomena of horizontal tubes under low pressure and low flow conditions is carried out. The phenomena covered in this work are measurement of diabatic single phase and subcooled boiling pressure drop and local heat transfer coefficients, steady state CHF, effect of upstream flow restrictions on flow transients and CHF, CHF under oscillatory flow and flow decreasing transients. A detailed literature review is carried out on CHF in horizontal channels to take stock of the works being carried out along with current state of the art and to justify the motivation for the experimental study. This paper presents the review of available literature on horizontal CHF with the results of the experimental work. (author)

Design of semi-rigid type of flexible pavements

Directory of Open Access Journals (Sweden)

Pranshoo Solanki

2017-03-01

Full Text Available The primary objective of the study presented in this paper is to develop design curves for performance prediction of stabilized layers and to compare semi-rigid flexible pavement designs between the empirical AASHTO 1993 and the mechanistic-empirical pavement design methodologies. Specifically, comparisons were made for a range of different sections consisting of cementitious layers stabilized with different types and percentages of additives. It is found that the design thickness is influenced by the type of soil, additive, selection of material property and design method. Cost comparisons of sections stabilized with different percentage and type of additives showed that CKD-stabilization provides economically low cost sections as compared to lime- and CFA-stabilized sections. Knowledge gained from the parametric analysis of different sections using AASHTO 1993 and MEPDG is expected to be useful to pavement designers and others in implementation of the new MEPDG for future pavement design. Keywords: Semi-rigid, Mechanistic, Resilient modulus, Fatigue life, Reliability, Traffic

2002–2012: 10 Years of Research Progress in Horizontal-Axis Marine Current Turbines

Directory of Open Access Journals (Sweden)

Kai-Wern Ng

2013-03-01

Full Text Available Research in marine current energy, including tidal and ocean currents, has undergone significant growth in the past decade. The horizontal-axis marine current turbine is one of the machines used to harness marine current energy, which appears to be the most technologically and economically viable one at this stage. A number of large-scale marine current turbines rated at more than 1 MW have been deployed around the World. Parallel to the development of industry, academic research on horizontal-axis marine current turbines has also shown positive growth. This paper reviews previous research on horizontal-axis marine current turbines and provides a concise overview for future researchers who might be interested in horizontal-axis marine current turbines. The review covers several main aspects, such as: energy assessment, turbine design, wakes, generators, novel modifications and environmental impact. Future trends for research on horizontal-axis marine current turbines are also discussed.

Research on typical topologies of a tubular horizontal-gap passive magnetic levitation vibration isolator

Directory of Open Access Journals (Sweden)

Zhou Yiheng

2017-01-01

Full Text Available Magnetic levitation vibration isolators have attracted more and more attention in the field of high-precision measuring and machining equipment. In this paper, we describe a tubular horizontal-gap passive magnetic levitation vibration isolator. Four typical topologies of the tubular horizontal-gap passive magnetic levitation vibration isolator are proposed. The analytical expression of magnetic force is derived. The relationship between levitation force, force density, force ripple and major structural parameters are analysed by finite element method, which is conductive to the design and optimization of the tubular horizontal-gap passive magnetic levitation vibration isolator. The force characteristics of different topologies of the tubular horizontal-gap passive magnetic levitation vibration isolator are compared and evaluated from the aspect of force density, force ripple and manufacturability. In comparison with conventional passive magnetic levitation vibration isolators, the proposed tubular horizontal-gap passive magnetic levitation vibration isolator shows advantage in higher force density.

New modelling of transient well test and rate decline analysis for a horizontal well in a multiple-zone reservoir

International Nuclear Information System (INIS)

Nie, Ren-Shi; Guo, Jian-Chun; Jia, Yong-Lu; Zhu, Shui-Qiao; Rao, Zheng; Zhang, Chun-Guang

2011-01-01

The no-type curve with negative skin of a horizontal well has been found in the current research. Negative skin is very significant to transient well test and rate decline analysis. This paper first presents the negative skin problem where the type curves with negative skin of a horizontal well are oscillatory. In order to solve the problem, we propose a new model of transient well test and rate decline analysis for a horizontal well in a multiple-zone composite reservoir. A new dimensionless definition of r D is introduced in the dimensionless mathematical modelling under different boundaries. The model is solved using the Laplace transform and separation of variables techniques. In Laplace space, the solutions for both constant rate production and constant wellbore pressure production are expressed in a unified formula. We provide graphs and thorough analysis of the new standard type curves for both well test and rate decline analysis; the characteristics of type curves are the reflections of horizontal well production in a multiple-zone reservoir. An important contribution of our paper is that our model removed the oscillation in type curves and thus solved the negative skin problem. We also show that the characteristics of type curves depend heavily on the properties of different zones, skin factor, well length, formation thickness, etc. Our research can be applied to a real case study

Partition efficiencies of newly fabricated universal high-speed counter-current chromatograph for separation of two different types of sugar derivatives with organic-aqueous two-phase solvent systems

Science.gov (United States)

Shinomiya, Kazufusa; Sato, Kazuki; Yoshida, Kazunori; Tokura, Koji; Maruyama, Hiroshi; Yanagidaira, Kazuhiro; Ito, Yoichiro

2013-01-01

Universal high-speed counter-current chromatograph (HSCCC) was newly designed and fabricated in our laboratory. It holds a set of four column holders symmetrically around the rotary frame at a distance of 11.2 cm from the central axis. By engaging the stationary gear on the central axis of the centrifuge to the planetary gears on the column holder shaft through a set of idle gears, two pairs of diagonally located column holders simultaneously rotate about their own axes in the opposite directions: one forward (type-J planetary motion) and the other backward (type-I planetary motion) each synchronously with the revolution. Using the eccentric coil assembly, partition efficiencies produced by these two planetary motions were compared on the separation of two different types of sugar derivatives (4-methylumbelliferyl and 5-bromo-4-chloro-3-indoxyl sugar derivatives) using organic-aqueous two-phase solvent systems composed of n-hexane/ethyl acetate/1-butanol/methanol/water and aqueous 0.1 M sodium tetraborate, respectively. With lower phase mobile, better peak resolution was obtained by the type-J forward rotation for both samples probably due to higher retention of the stationary phase. With upper phase mobile, however, similar peak resolutions were obtained between these two planetary motions for both sugar derivatives. The overall results indicate that the present universal HSCCC is useful for counter-current chromatographic separation since each planetary motion has its specific applications: e.g., vortex CCC by the type-I planetary motion and HSCCC by the type-J planetary motion both for separation of various natural and synthetic products. PMID:24267319

Conceptual design of ball-screw type control element drive mechanism

Energy Technology Data Exchange (ETDEWEB)

Kim, Ji Ho; Kim, Jong In; Huh, Hyung [Korea Atomic Energy Research Institute, Taejon (Korea)

1999-10-01

In this report, the design features of ball-screw type CEDM with fine-step movement capability are described. The contents of this report are as follows: -Review of Design Requirements for Ball-screw type CEDM -System Description for Ball-screw type CEDM -Design of Ball Bearing and Ball-screw Assembly -Detail Design of Rotary Step Motor -Detail Design of Angular Position Indicator -Materials. The Ball-screw type CEDM described in this report is to be utilized as the starting point for design development of CEDM for SMART. 11 refs., 43 figs., 3 tabs. (Author)

Maximizing productivity of horizontal drilling and completion techniques

Energy Technology Data Exchange (ETDEWEB)

Schein, G. [BJ Services Company, Calgary, AB (Canada)

2007-07-01

There are currently 160 active drilling rigs in the Barnett shale play, and small early developments have now become large-scale operations. This presentation outlined methods currently used to improve the productivity of directional drilling and completion techniques in gas shale plays. Horizontal completions are used to control height growth and increase contact areas. A typical horizontal well casing program was described along with details of cement liner treatment programs. Charts of optimum and non-optimum azimuth wells were included. Increased reservoir contact has been achieved by using limited-entry designs and acid stages with ball-sealers and abrasive jet-cutters. Pump rates have been increased during various stages, and larger fluid and sand volumes were used. A mineralogy comparison was provided, as well as details of the general design criteria for vertical wells in the region. It was concluded that drilling in the Barnett shale play has been successful as a result of using 3-dimensional seismic mapping as well as by initiating multiple, simultaneous fracs. The presentation also included charts of the Arkoma-Woodford play, the Arkoma-Fayetteville play, and the Delaware Basin. tabs., figs.

Active vibration suppression of helicopter horizontal stabilizers

Science.gov (United States)

Cinquemani, Simone; Cazzulani, Gabriele; Resta, Ferruccio

2017-04-01

Helicopters are among the most complex machines ever made. While ensuring high performance from the aeronautical point of view, they are not very comfortable due to vibration mainly created by the main rotor and by the interaction with the surrounding air. One of the most solicited structural elements of the vehicle are the horizontal stabilizers. These elements are particularly stressed because of their composite structure which, while guaranteeing lightness and strength, is characterized by a low damping. This work makes a preliminary analysis on the dynamics of the structure and proposes different solutions to actively suppress vibrations. Among them, the best in terms of the relationship between performance and weight / complexity of the system is that based on inertial actuators mounted on the inside of the horizontal stabilizers. The work addresses the issue of the design of the device and its use in the stabilizer from both the numerical and the experimental points of view.

Modifiable clinical and lifestyle factors are associated with elevated alanine aminotransferase levels in newly diagnosed type 2 diabetes patients

DEFF Research Database (Denmark)

Mor, Anil; Svensson, Elisabeth; Rungby, Jørgen

2014-01-01

BACKGROUND: Current literature lacks data on markers of non-alcoholic fatty liver disease (NAFLD) in newly diagnosed type 2 diabetes mellitus (T2DM) patients. We therefore, conducted a cross-sectional study to examine modifiable clinical and lifestyle factors associated with elevated alanine...... aminotransferase (ALT) levels as a marker of NAFLD in new T2DM patients. METHODS: Alanine aminotransferase levels were measured in 1026 incident T2DM patients enrolled in the nationwide Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort. We examined prevalence of elevated ALT (>38 IU/L for women....../L (interquartile range: 22-41 IU/L) in men. Elevated ALT was found in 16% of incident T2DM patients. The risk of elevated ALT was increased in patients who were diabetes debut [adjusted prevalence ratio (aPR): 1.96, 95% confidence interval (CI): 1.15-3.33], in those with alcohol overuse (>14...

HORIZONTAL LIFTING OF 5 DHLW/DOE LONG, 12-PWR LONG AND 24-BWR WASTE PACKAGES

International Nuclear Information System (INIS)

V. de la Brosse

2001-01-01

The objective of this calculation was to determine the structural response of a 12-Pressurized Water Reactor (PWR) Long, a 24-Boiling Water Reactor (BWR) and a 5-Defense High Level Waste/Department of Energy (DHLW/DOE)--Long spent nuclear fuel waste packages lifted in a horizontal position. The scope of this calculation was limited to reporting the calculation results in terms of maximum stress intensities in the trunnion collar sleeves. In addition, the maximum stress intensities in the inner and outer shells of the waste packages were presented for illustrative purposes. The information provided by the sketches (Attachments I, II and III) is that of the potential design of the types of waste packages considered in this calculation, and all obtained results are valid for these designs only. This calculation is associated with the waste package design and was performed by the Waste Package Design Section in accordance with the ''Technical work plan for: Waste Package Design Description for LA'' (Ref. 7). AP-3.12Q, Calculations (Ref. 13), was used to perform the calculation and develop the document

Packaging design criteria for the Type B Drum

International Nuclear Information System (INIS)

Edwards, W.S.; Smith, R.J.; Wells, A.H.

1995-09-01

The Type B Drum package is a transportation cask capable of shipping a single 55-gal (208 L) drum of transuranic (TRU) waste. The Type B Drum is smaller than existing certified packages, such as the TRUPACT-II cask, but will allow payloads with higher thermal and gas generation rates, thus providing greater operational flexibility. The Type B Drum package has double containment so that plutonium contents and other radioactive material may be transported in Type B quantities. Conceptual designs of unshielded and shielded versions of the Type B Drum were completed in Report on the Conceptual Design of the Unshielded Type B Drum Packaging and Report on the Conceptual Design of the Shielded type B Drum Packaging (WEC 1994a, WEC 1994b), which demonstrated the Type B Drum to be a viable packaging system. A Type B package containment system must withstand the normal conditions of transport and the hypothetical accident conditions, which include a 9-m (30-ft) drop onto an unyielding surface and a 1-m (3-ft) drop onto a 15-cm (6-in.) diameter pin, and a fire and immersion scenarios

The design process seen through the eyes of a type designer

DEFF Research Database (Denmark)

Beier, Sofie

2015-01-01

To understand how the design process works, the paper takes the outset in the work of one of the first innovating type designers: the English printer and typefounder John Baskerville (1706-1775). By comparing his way of working with a model for a contemporary design process, the paper reflects upon...

Analytical solution of velocity for ammonia-water horizontal falling-film flow

International Nuclear Information System (INIS)

Zhang, Qiang; Gao, Yide

2016-01-01

Highlights: • We built a new falling-film flow model that analyzed the film flow characteristics. • We have obtained a new formula of film thickness over the horizontal tube. • We derived analysis solution to analyze the effect of inertial force to velocity in the entrance region of liquid film. • It described the characters of the ammonia-waterfalling-film film over the horizontal tube. • It is good for falling-film absorption, generation and evaporation to optimizing the design parameters and further improving the capabilities. - Abstract: A new horizontal tube falling film velocity model was built and calculated to analyze the problem of film flow conditions. This model also analyzed the film thickness distribution in horizontal tube falling film flow and considered the effect of the inertial force on velocity. The film thickness and velocity profile can be obtained based on the principle of linear superposition, a method of separation of variables that introduces the effect of variable inertial force on the velocity profile in the process of falling-film absorption. The film flow condition and the film thickness distribution at different fluid Reynolds numbers (Re) and tube diameters were calculated and compared with the results of the Crank–Nicolson numerical solution under the same conditions. The results show that the film flow condition out of a horizontal tube and that the film thickness increases with the fluid Re. At a specific Re and suitable tube diameter, the horizontal tube reaches a more uniform film. Finally, the analysis results have similar trend with the experimental and numerical predicted data in literature.

Vertical and horizontal integration of knowledge and skills - a working model.

Science.gov (United States)

Snyman, W D; Kroon, J

2005-02-01

The new integrated outcomes-based curriculum for dentistry was introduced at the University of Pretoria in 1997. The first participants graduated at the end of 2001. Educational principles that underpin the new innovative dental curriculum include vertical and horizontal integration, problem-oriented learning, student-centred learning, a holistic attitude to patient care and the promotion of oral health. The aim of this research project was to develop and assay a model to facilitate vertical integration of knowledge and skills thereby justifying the above mentioned action. The learning methodology proposed for the specific outcome of the Odontology module, namely the diagnosis of dental caries and the design of a primary preventive programme, included problem-solving as the driving force for the facilitation of vertical and horizontal integration, and an instructional design for the integration of the basic knowledge and clinical skills into a single learning programme. The paper describes the methodology of problem-oriented learning as applied in this study together with the detail of the programme. The consensus of those teachers who represent the basic and clinical sciences and who participate in this learning programme is that this model is practical and can assist vertical as well as horizontal integration of knowledge.

Horizontal drilling under Lake Erie

Energy Technology Data Exchange (ETDEWEB)

Meller, R.

2001-07-01

Drilling oil wells under Lake Erie calls for horizontal drilling wells to be drilled from shore out into the pay-zone under the lake. The nature and characteristics of horizontal wells as compared to vertical wells are explored. Considerations that have to be taken into account in drilling horizontal wells are explained (the degree of curvature, drilling fluid quality, geosteering in the pay-zone, steering instrumentation, measurements while drilling (MWD), logging while drilling (LWD)). The concept and reasons for extended reach wells are outlined, along with characteristic features of multilateral wells.

Combined horizontal and vertical integration of care: a goal of practice-based commissioning.

Science.gov (United States)

Thomas, Paul; Meads, Geoffrey; Moustafa, Ahmet; Nazareth, Irwin; Stange, Kurt C; Donnelly Hess, Gertrude

2008-01-01

Practice-based commissioning (PBC) in the UK is intended to improve both the vertical and horizontal integration of health care, in order to avoid escalating costs and enhance population health. Vertical integration involves patient pathways to treat named medical conditions that transcend organisational boundaries and connect community-based generalists with largely hospital-sited specialists, whereas horizontal integration involves peer-based and cross-sectoral collaboration to improve overall health. Effective mechanisms are now needed to permit ongoing dialogue between the vertical and horizontal dimensions to ensure that medical and nonmedical care are both used to their best advantage. This paper proposes three different models for combining vertical and horizontal integration - each is a hybrid of internationally recognised ideal types of primary care organisation. Leaders of PBC should consider a range of models and apply them in ways that are relevant to the local context. General practitioners, policy makers and others whose job it is to facilitate horizontal and vertical integration must learn to lead such combined approaches to integration if the UK is to avoid the mistakes of the USA in over-medicalising health issues.

Design type testing for digital instrumentation and control systems

International Nuclear Information System (INIS)

Bastl, W.; Mohns, G.

1997-01-01

The design type qualification of digital safety instrumentation and control is outlined. Experience shows that the concepts discussed, derived from codes, guidelines and standards, achieve useful results. It has likewise become clear that the systematics of design type qualification of the hardware components is also applicable to the software components. Design type qualification of the software, a premiere, could be performed unexpectedly smoothly. The hardware design type qualification proved that the hardware as a substrate of functionality and reliability is an issue that demands full attention, as compared to conventional systems. Another insight is that design qualification of digital instrumentation and control systems must include plant-independent systems tests. Digital instrumentation and control systems simply work very differently from conventional control systems, so that this testing modality is inevitable. (Orig./CB) [de

Horizontal Gene Transfers in Mycoplasmas (Mollicutes).

Science.gov (United States)

Citti, C; Dordet-Frisoni, E; Nouvel, L X; Kuo, C H; Baranowski, E

2018-04-12

The class Mollicutes (trivial name "mycoplasma") is composed of wall-less bacteria with reduced genomes whose evolution was long thought to be only driven by gene losses. Recent evidences of massive horizontal gene transfer (HGT) within and across species provided a new frame to understand the successful adaptation of these minimal bacteria to a broad range of hosts. Mobile genetic elements are being identified in a growing number of mycoplasma species, but integrative and conjugative elements (ICEs) are emerging as pivotal in HGT. While sharing common traits with other bacterial ICEs, such as their chromosomal integration and the use of a type IV secretion system to mediate horizontal dissemination, mycoplasma ICEs (MICEs) revealed unique features: their chromosomal integration is totally random and driven by a DDE recombinase related to the Mutator-like superfamily. Mycoplasma conjugation is not restricted to ICE transmission, but also involves the transfer of large chromosomal fragments that generates progenies with mosaic genomes, nearly every position of chromosome being mobile. Mycoplasmas have thus developed efficient ways to gain access to a considerable reservoir of genetic resources distributed among a vast number of species expanding the concept of minimal cell to the broader context of flowing information.

Scheduling and shift work characteristics associated with risk for occupational injury in newly licensed registered nurses: An observational study.

Science.gov (United States)

Stimpfel, Amy Witkoski; Brewer, Carol S; Kovner, Christine T

2015-11-01

Registered nurses across the globe bear a heavy injury burden. Every shift, nurses are exposed to a variety of hazards that can jeopardize their health, which negatively impacts their ability to provide high-quality patient care. Previous research suggests that inexperienced, or newly licensed nurses, may have an increased risk for certain occupational injuries. However, the current knowledge base is insufficient to fully understand how work hours influence newly licensed nurses' occupational injury, given the significant variation in hospital organization and work characteristics. To describe newly licensed nurses' shift work characteristics and determine the association between shift type and scheduling characteristics and nurse injury, before and after adjusting for individual and combined effects of demographics, external context, organizational context, and work context, following the Organization of Work model. This study is a secondary analysis of a nationally representative survey of newly licensed registered nurses using a cross-sectional design. The analytic sample includes 1744 newly licensed registered nurses from 34 states and the District of Columbia who reported working in a hospital and were within 6-18 months of passing their state licensure exam at the time of survey administration. Descriptive statistics were calculated, followed by bivariate and multivariate Poisson regression models to assess the relationship between shift type and scheduling characteristics and nurse injury. Lastly, full models with the addition of demographics, external context, organizational context, and work context variables were calculated. The majority (79%) of newly licensed nurses worked 12-h shifts, a near majority worked night shift (44%), and over half (61%) worked overtime (mandatory or voluntary) weekly. Nurses working weekly overtime were associated with a 32% [incidence rate ratio (IRR) 1.32, CI 1.07-1.62] increase in the risk of a needle stick and nurses

FIRST PHOTOMETRIC INVESTIGATION OF THE NEWLY DISCOVERED W UMa-TYPE BINARY STAR MR Com

Energy Technology Data Exchange (ETDEWEB)

Qian, S.-B.; Liu, N.-P.; Liao, W.-P.; He, J.-J.; Liu, L.; Zhu, L.-Y.; Wang, J.-J.; Zhao, E.-G., E-mail: qsb@ynao.ac.cn [Yunnan Observatories, Chinese Academy of Sciences (CAS), P.O. Box 110, 650011 Kunming (China)

2013-08-01

By analyzing multi-color light curves of the newly discovered W UMa-type binary, MR Com, we discovered that it is a shallow-contact binary with a degree of contact factor of f = 10.0% {+-} 2.1%. Photometric solutions reveal that MR Com is a W-type system with a mass ratio of q = 3.9 where the less massive component is about 90 K hotter than the more massive one. By investigating all of the available times of minimum light, we found that the general trend of the Observed-Calculated (O - C) curve shows a downward parabolic variation while it undergoes a cyclic variation with a small amplitude of 0.0031 days and a period of 10.1 yr. The downward parabolic change corresponds to a long-term decrease in the orbital period at a rate of P-dot = -5.3 x 10{sup -7} days yr{sup -1} that may be caused by a combination of a mass transfer and an angular momentum loss (AML) via magnetic braking. Among the 16 shallow-contact systems with a decreasing orbital period, MR Com has the lowest mass ratio (e.g., 1/q = 0.26). The shallow-contact configuration, the low-mass ratio, and the long-term period decrease all suggest that systems similar to MR Com are on the AML-controlled stage of the evolutionary scheme proposed by Qian. They will oscillate around a critical mass ratio and evolve into a deep contact with a higher mass ratio. The small-amplitude cyclic change in the O - C curve was analyzed for the light-travel time effect via the presence of an extremely cool stellar companion.

Requirements report for SSTO vertical take-off and horizontal landing vehicle

Science.gov (United States)

Greenberg, H. S.

1994-01-01

This document describes the detailed design requirements and design criteria to support Structures/TPS Technology development for SSTO winged vehicle configurations that use vertical take-off and horizontal landing and delivers 25,000 lb payloads to a 220 nm circular orbit at an inclination of 51.6 degrees or 40,000 lb payloads to a 150 nm circular orbit at a 28.5 degree inclination.

Seismic fragility capacity of equipment--horizontal shaft pump test

International Nuclear Information System (INIS)

Iijima, T.; Abe, H.; Suzuki, K.

2005-01-01

The current seismic fragility capacity of horizontal shaft pump is 1.6 x 9.8 m/s 2 (1.6 g), which was decided from previous vibration tests and we believe that it must have sufficient margin. The purpose of fragility capacity test is to obtain realistic seismic fragility capacity of horizontal shaft pump by vibration tests. Reactor Building Closed Cooling Water (RCW) Pump was tested as a typical horizontal shaft pump, and then bearings and liner rings were tested as important parts to evaluate critical acceleration and dispersion. Regarding RCW pump test, no damage was found, though maximum input acceleration level was 6 x 9.8 m/s 2 (6 g). Some kinds of bearings and liner rings were tested on the element test. Input load was based on seismic motion which was same with the RCW pump test, and maximum load was equivalent to over 20 times of design seismic acceleration. There was not significant damage that caused emergency stop of pump but degradation of surface roughness was found on some kinds of bearings. It would cause reduction of pump life, but such damage on bearings occurred under large seismic load condition that was equivalent to over 10 to 20 g force. Test results show that realistic fragility capacity of horizontal shaft pump would be at least four times as higher as current value which has been used for our seismic PSA. (authors)

Penetrating particles in horizontal air showers

International Nuclear Information System (INIS)

Wohlenberg, J.; Boehm, E.

1975-01-01

Particle density and arrival time of muons has been measured in Horizontal Air Showers. 5,600 showers have been recorded in 7,800 hours. Using stringent selection criteria 155 showers have been found horizontal (zenith angle larger 70 0 ) in the size range 4.1 > lg N > 5.5. The muons observed in these showers can be explained by purely electromagnetic origin of horizontal showers. (orig.) [de

MARS-KS Code Assessment for Condensation Heat Transfer in Horizontal Tube with the Presence of Non-Condensable Gas using Purdue Experiment

International Nuclear Information System (INIS)

Jeon, Seong Su; Lee, Byung Chul; Park, Ju Yeop; Seul, Kwang Won

2011-01-01

In South Korea, advanced power reactor plus (APR+), as a Korean specific reactor, is currently under development for the export strategy. In order to raise competitiveness of the APR+ in the world market, it is necessary to develop the original technology for the improved technology, economics, and safety features. For this purpose, a passive auxiliary feedwater system (PAFS) was adopted as an improved safety design concept of APR+: and then there have been many efforts to develop the PAFS. According to PAFS design concept, PAFS can completely replace the auxiliary feedwater system. When the design basis accident, in which feedwater is unavailable, occurs, the PAFS can remove the residual heat in the core and then prevent the core damage. In the PAFS with the horizontal type heat exchanger, two-phase natural circulation, condensation heat transfer in tube, boiling heat transfer in pool, natural convection in pool, etc. are considered as very important thermalhydraulic phenomena (see Fig. 1). Compared with the vertical heat exchanger from these phenomena, the major difference of the horizontal heat exchanger is the condensation heat transfer phenomena in the tube side. There have been many efforts to understand the condensation heat transfer with in the presence of NC gas in tube but most researches focused on the condensation heat transfer in vertical tube. Therefore the details of the condensation heat transfer in the presence of NC gas in horizontal condenser tubes are not well understood. In order to develop the safety evaluation system for APR+ PAFS, it is required to evaluate the capability and applicability of the MARS-KS code for modeling the condensation heat transfer in the horizontal tube with NC gas because many heat transfer correlations in MARS-KS are known to have much uncertainty. In particular, there is no reliable model for the condensation phenomena in horizontal tube with NC gas. In order to assess the MARS-KS code results and identify the

Lifestyle and clinical factors associated with elevated C-reactive protein among newly diagnosed Type 2 diabetes mellitus patients: a cross-sectional study from the nationwide DD2 cohort.

Science.gov (United States)

Svensson, Elisabeth; Mor, Anil; Rungby, Jørgen; Berencsi, Klara; Nielsen, Jens Steen; Stidsen, Jacob V; Friborg, Søren; Brandslund, Ivan; Christiansen, Jens Sandahl; Beck-Nielsen, Henning; Sørensen, Henrik Toft; Thomsen, Reimar W

2014-08-28

We aimed to examine the prevalence of and modifiable factors associated with elevated C-reactive Protein (CRP), a marker of inflammation, in men and women with newly diagnosed Type 2 Diabetes mellitus (DM) in a population-based setting. CRP was measured in 1,037 patients (57% male) with newly diagnosed Type 2 DM included in the prospective nationwide Danish Centre for Strategic Research in Type 2 Diabetes (DD2) project. We assessed the prevalence of elevated CRP and calculated relative risks (RR) examining the association of CRP with lifestyle and clinical factors by Poisson regression, stratified by gender. We used linear regression to examine the association of CRP with other biomarkers. The median CRP value was 2.1 mg/L (interquartile range, 1.0 - 4.8 mg/L). In total, 405 out of the 1,037 Type 2 DM patients (40%) had elevated CRP levels (>3.0 mg/L). More women (46%) than men (34%) had elevated CRP. Among women, a lower risk of elevated CRP was observed in patients receiving statins (adjusted RR (aRR) 0.7 (95% confidence interval (CI) 0.6-0.9)), whereas a higher risk was seen in patients with central obesity (aRR 2.3 (95% CI 1.0-5.3)). For men, CRP was primarily elevated among patients with no regular physical activity (aRR 1.5 (95% CI 1.1-1.9)), previous cardiovascular disease (aRR1.5 (95% CI 1.2-1.9) and other comorbidity. For both genders, elevated CRP was 1.4-fold increased in those with weight gain >30 kg since age 20 years. Sensitivity analyses showed consistent results with the full analysis. The linear regression analysis conveyed an association between high CRP and increased fasting blood glucose. Among newly diagnosed Type 2 DM patients, 40% had elevated CRP levels. Important modifiable risk factors for elevated CRP may vary by gender, and include low physical activity for men and central obesity and absence of statin use for women.

Horizontal transfers of Mariner transposons between mammals and insects

Directory of Open Access Journals (Sweden)

Oliveira Sarah G

2012-09-01

Full Text Available Abstract Background Active transposable elements (TEs can be passed between genomes of different species by horizontal transfer (HT. This may help them to avoid vertical extinction due to elimination by natural selection or silencing. HT is relatively frequent within eukaryotic taxa, but rare between distant species. Findings Closely related Mariner-type DNA transposon families, collectively named as Mariner-1_Tbel families, are present in the genomes of two ants and two mammalian genomes. Consensus sequences of the four families show pairwise identities greater than 95%. In addition, mammalian Mariner1_BT family shows a close evolutionary relationship with some insect Mariner families. Mammalian Mariner1_BT type sequences are present only in species from three groups including ruminants, tooth whales (Odontoceti, and New World leaf-nosed bats (Phyllostomidae. Conclusions Horizontal transfer accounts for the presence of Mariner_Tbel and Mariner1_BT families in mammals. Mariner_Tbel family was introduced into hedgehog and tree shrew genomes approximately 100 to 69 million years ago (MYA. Most likely, these TE families were transferred from insects to mammals, but details of the transfer remain unknown.

Patients with newly diagnosed Rheumatoid Arthritis are at increased risk of Diabetes Mellitus

DEFF Research Database (Denmark)

Emamifar, Amir; Levin, Klaus; Jensen Hansen, Inger Marie

2018-01-01

-C-reactive protein (DAS28-CRP) at the time of diagnosis and after 4 months (±1-2 months) of treatment initiation were extracted from Danbio Registry. To reveal the presence of DM, patients' electronic medical records were reviewed. The prevalence of DM in our patients was compared (using an age- and gender......-matched analysis) with that expected from Danish population. RESULTS: of 439 included patients, 60.1% were female, mean of age 64.6±15.0 years and RA disease duration 2.6±1.7 years. Prevalence of DM was 57/439 (12.9%), herein type II DM 52 (91.2%) and type I DM 5 (8.8%). Except for two patients, diagnosis of DM......AIMS: To reveal the prevalence of Diabetes Mellitus (DM) in patients with newly diagnosed Rheumatoid Arthritis (RA) and evaluate the association between clinical characteristics of RA and DM as well as treatment response in newly diagnosed RA patients with DM. METHODS: Newly diagnosed, adult, RA...

Study of the Local Horizon. (Spanish Title: Estudio del Horizonte Local.) Estudo do Horizonte Local

Science.gov (United States)

Ros, Rosa M.

2009-12-01

The study of the horizon is fundamental to easy the first observations of the students at any education center. A simple model, to be developed in each center, allows to easy the study and comprehension of the rudiments of astronomy. The constructed model is presented in turn as a simple equatorial clock, other models (horizontal and vertical) may be constructed starting from it. El estudio del horizonte es fundamental para poder facilitar las primeras observaciones de los alumnos en un centro educativo. Un simple modelo, que debe realizarse para cada centro, nos permite facilitar el estudio y la comprensión de los primeros rudimentos astronómicos. El modelo construido se presenta a su vez como un sencillo modelo de reloj ecuatorial y a partir de él se pueden construir otros modelos (horizontal y vertical). O estudo do horizonte é fundamental para facilitar as primeiras observações dos alunos num centro educativo. Um modelo simples, que deve ser feito para cada centro, permite facilitar o estudo e a compreensão dos primeiros rudimentos astronômicos. O modelo construído apresenta-se, por sua vez, como um modelo simples de relógio equatorial e a partir dele pode-se construir outros modelos (horizontal e vertical)

An irradiation facility with a horizontal beam for radiobiological studies

International Nuclear Information System (INIS)

Czub, J.; Banas, D.; Braziewicz, J.; Choinski, J.; Jaskola, M.; Korman, A.; Szeflinski, Z.; Wojcik, A.

2006-01-01

A facility with a horizontal beam for radiobiological experiments with heavy ions has been designed and constructed at the Heavy Ion Laboratory in Warsaw Univ.. The facility is optimal to investigate the radiobiological effects of charged heavy particles on a cellular or molecular level as in the region of the Bragg peak. (authors)

Innovative IPV from attenuated Sabin poliovirus or newly designed alternative seed strains.

Science.gov (United States)

Hamidi, Ahd; Bakker, Wilfried A M

2012-11-01

This article gives an overview of the patent literature related to innovative inactivated polio vaccine (i-IPV) based on using Sabin poliovirus strains and newly developed alternative recombinant poliovirus strains. This innovative approach for IPV manufacturing is considered to attribute to the requirement for affordable IPV in the post-polio-eradication era, which is on the horizon. Although IPV is a well-established vaccine, the number of patent applications in this field was seen to have significantly increased in the past decade. Currently, regular IPV appears to be too expensive for universal use. Future affordability may be achieved by using alternative cell lines, alternative virus seed strains, improved and optimized processes, dose sparing, or the use of adjuvants. A relatively short-term option to achieve cost-price reduction is to work on regular IPV, using wild-type poliovirus strains, or on Sabin-IPV, based on using attenuated poliovirus strains. This price reduction can be achieved by introducing efficiency in processing. There are also multiple opportunities to work on dose sparing, for example, by using adjuvants or fractional doses. Renewed interest in this field was clearly reflected in the number and diversity of patent applications. In a later stage, several innovative approaches may become even more attractive, for example the use of recombinant virus strains or even a totally synthetic vaccine. Currently, such work is mainly carried out by research institutes and universities and therefore clinical data are not available.

Validity of a Newly-Designed Rectilinear Stepping Ergometer Submaximal Exercise Test to Assess Cardiorespiratory Fitness.

Science.gov (United States)

Zhang, Rubin; Zhan, Likui; Sun, Shaoming; Peng, Wei; Sun, Yining

2017-09-01

The maximum oxygen uptake (V̇O 2 max), determined from graded maximal or submaximal exercise tests, is used to classify the cardiorespiratory fitness level of individuals. The purpose of this study was to examine the validity and reliability of the YMCA submaximal exercise test protocol performed on a newly-designed rectilinear stepping ergometer (RSE) that used up and down reciprocating vertical motion in place of conventional circular motion and giving precise measurement of workload, to determine V̇O 2 max in young healthy male adults. Thirty-two young healthy male adults (32 males; age range: 20-35 years; height: 1.75 ± 0.05 m; weight: 67.5 ± 8.6 kg) firstly participated in a maximal-effort graded exercise test using a cycle ergometer (CE) to directly obtain measured V̇O 2 max. Subjects then completed the progressive multistage test on the RSE beginning at 50W and including additional stages of 70, 90, 110, 130, and 150W, and the RSE YMCA submaximal test consisting of a workload increase every 3 minutes until the termination criterion was reached. A metabolic equation was derived from the RSE multistage exercise test to predict oxygen consumption (V̇O 2 ) from power output (W) during the submaximal exercise test (V̇O 2 (mL·min -1 )=12.4 ×W(watts)+3.5 mL·kg -1 ·min -1 ×M+160mL·min -1 , R 2 = 0.91, standard error of the estimate (SEE) = 134.8mL·min -1 ). A high correlation was observed between the RSE YMCA estimated V̇O 2 max and the CE measured V̇O 2 max (r=0.87). The mean difference between estimated and measured V̇O 2 max was 2.5 mL·kg -1 ·min -1 , with an SEE of 3.55 mL·kg -1 ·min -1 . The data suggest that the RSE YMCA submaximal exercise test is valid for predicting V̇O 2 max in young healthy male adults. The findings show that the rectilinear stepping exercise is an effective submaximal exercise for predicting V̇O 2 max. The newly-designed RSE may be potentially further developed as an alternative ergometer for assessing

Finite element prediction on the chassis design of UniART4 racing car

Science.gov (United States)

Zaman, Z. I.; Basaruddin, K. S.; Basha, M. H.; Rahman, M. T. Abd; Daud, R.

2017-09-01

This paper presents the analysis and evaluation of the chassis design for University Automotive Racing Team No. 4 (UniART4) car based on finite element analysis. The existing UniART4 car chassis was measured and modelled geometrically using Solidwork before analysed in FEA software (ANSYS). Four types of static structural analysis were used to predict the chassis design capability under four different loading conditions; vertical bending, lateral bending, lateral torsion and horizontal lozenging. The results showed the chassis subjected to the highest stress and strain under horizontal lozenging, whereas the minimum stress and strain response was obtained under lateral bending. The present analysis result could provide valuable information in predicting the sustainability of the current UniART car chassis design.

Software tool for horizontal-axis wind turbine simulation

Energy Technology Data Exchange (ETDEWEB)

Vitale, A.J. [Instituto Argentino de Oceanografia, Camino La Carrindanga Km. 7, 5 CC 804, B8000FWB Bahia Blanca (Argentina); Universidad Tecnologica Nacional Facultad Regional Bahia Blanca, GESE, 11 de Abril 461, B8000LMI Bahia Blanca (Argentina); Dpto. de Ing. Electrica y de Computadoras, Universidad Nacional del Sur, Av. Alem 1253, 8000 Bahia Blanca (Argentina); Rossi, A.P. [Universidad Tecnologica Nacional Facultad Regional Bahia Blanca, GESE, 11 de Abril 461, B8000LMI Bahia Blanca (Argentina); Dpto. de Ing. Electrica y de Computadoras, Universidad Nacional del Sur, Av. Alem 1253, 8000 Bahia Blanca (Argentina)

2008-07-15

The main problem of a wind turbine generator design project is the design of the right blades capable of satisfying the specific energy requirement of an electric system with optimum performance. Once the blade has been designed for optimum operation at a particular rotor angular speed, it is necessary to determine the overall performance of the rotor under the range of wind speed that it will encounter. A software tool that simulates low-power, horizontal-axis wind turbines was developed for this purpose. With this program, the user can calculate the rotor power output for any combination of wind and rotor speeds, with definite blade shape and airfoil characteristics. The software also provides information about distribution of forces along the blade span, for different operational conditions. (author)

Triglyceride to high-density lipoprotein cholesterol ratio and carotid intima-medial thickness in Chinese adolescents with newly diagnosed type 2 diabetes mellitus.

Science.gov (United States)

Li, Xin; Deng, You-Ping; Yang, Miao; Wu, Yu-Wen; Sun, Su-Xin; Sun, Jia-Zhong

2016-03-01

To investigate the relationship between triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and carotid intima-medial thickness (CIMT) in Chinese youth and adolescents with newly diagnosed type 2 diabetes mellitus (T2DM). Ninety-eight subjects aged 10-24 yr with newly-diagnosed T2DM had general inflammation, anthropometric, laboratory and CIMT data collected, and were divided into three groups based on TG/HDL-C tertiles. There were no significant differences in gender, age, fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), and carotid arterial diameter (CAD) among the groups based on TG/HDL-C tertiles. Across TG/HDL-C tertiles, there was a significant progressive increase in body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), homeostasis model assessment-estimated insulin resistance (HOMA-IR), TG, total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C) and CIMT (all P < 0.01 or P < 0.05), while HDL-C was decreased significantly across the groups (P < 0.01). In general linear regression model, TG/HDL-C was an independent determinant of CIMT even after adjusting for BMI, SBP, DBP, TG, TC, LDL-C, HDL-C, HbA1c and HOMA-IR. TG/HDL-C ratio, the marker of small dense LDL particles, is an independent determinant of CIMT in Chinese youth and adolescents with newly diagnosed T2DM, and may be a simple and helpful tool in predicting the increased CIMT in such patients. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

1,5-anhydroglucitol is associated with early-phase insulin secretion in chinese patients with newly diagnosed type 2 diabetes mellitus.

Science.gov (United States)

Ma, Xiaojing; Hao, Yaping; Hu, Xiang; Luo, Yuqi; Deng, Zixuan; Zhou, Jian; Bao, Yuqian; Jia, Weiping

2015-05-01

The goal of the present study was to explore the correlations of 1,5-anhydroglucitol (l,5-AG), glycated hemoglobin (HbA1c), and glycated albumin (GA) with insulin sensitivity and secretion. In total, 302 patients with newly diagnosed type 2 diabetes mellitus (166 men, 136 women) were enrolled in this study. The homeostasis model assessment for insulin resistance (HOMA-IR) and homeostasis model assessment for β-cell function (HOMA-β) were calculated to determine the basal insulin sensitivity and secretion. The insulinogenic index (IGI) was used to evaluate early-phase insulin secretion. 1,5-AG and GA were assayed via the enzymatic method, and HbA1c was detected by high-pressure liquid chromatography. Among all 302 subjects, the serum 1,5-AG level was 13.1±7.2 μg/mL, and the HbA1c and GA levels [median (interquartile range)] were 6.7% (6.2-7.3%) and 17.7% (16.0-19.5%), respectively. Increased 1,5-AG quartiles were accompanied by trends toward a decreased HOMA-IR and an increased HOMA-β and IGI (for all trends, P1). 1,5-AG was negatively associated with HOMA-IR (r=-0.200, P1) and positively associated with HOMA-β and IGI (r=0.210 and 0.413, respectively; both P1). 1,5-AG was independently related to HOMA-IR and HOMA-β and exhibited an independent positive association with IGI (standardized β=0.242, P1). Additionally, both HbA1c and GA were independently correlated with HOMA-IR and HOMA-β. 1,5-AG is not only correlated with basal insulin sensitivity and secretion, but also closely associated with early-phase insulin secretion in Chinese patients with newly diagnosed type 2 diabetes mellitus.

A finite element model for analyzing horizontal well BHA behavior

Energy Technology Data Exchange (ETDEWEB)

Akgun, F. [Petroleum Engineering, The Petroleum Institute, P.O. Box 17555, Al-Ain (United Arab Emirates)

2004-04-01

Horizontal wells are proven to be better producers because they can be extended for a long distance in the pay zone. Engineers have the technical means to forecast the well productivity for a given horizontal length. However, experiences have shown that the actual production rate is often significantly less than that of forecasted. There are a number of reasons for the discrepancy of predicted to actual production rates in horizontal wells. However, it is a difficult task, if not impossible, to identify the real reason why a horizontal well is not producing what was forecasted. Often, the source of problem lies in the drilling of horizontal section such as permeability reduction in the pay zone due to mud invasion or snaky well patterns created during drilling. Although drillers aim to drill a constant inclination hole once in the pay zone, the more frequent outcome is a sinusoidal wellbore trajectory. Logging while drilling (LWD) and real time measurement of resistivity at bit help drill in the pay zone by constant monitoring of borehole trajectory and formation boundaries. Rotary steerable tools (RTS) allow spontaneous intervention to drilling direction and inclination if run with LWD tools. Nevertheless, there are still many cases where LWD cannot be deployed due to technical difficulties. One such case was noticed in the Middle East where LWD sensors were worn out completely during 1 h run time due to extreme formation abrasiveness. In the absence of LWD and RTS, it becomes a challenging task to drill a constant inclination borehole which will be addressed in this paper. The two factors, which play an important role in wellbore tortuosity, are the inclination and side force at bit. A constant inclination horizontal well can only be drilled if the bit face is maintained perpendicular to the longitudinal axis of bottom hole assembly (BHA) while keeping the side force nil at the bit. This approach assumes that there exists no formation force at bit. Hence, an

Requirements report for SSTO vertical take-off/horizontal landing vehicle

Science.gov (United States)

Greenberg, H. S.

1994-07-01

This document describes the detailed design requirements and design criteria to support Structures/TPS Technology development for SSTO winged vehicle configurations that use vertical take-off and horizontal landing and deliver 25,000 lb payloads to a 220 nm circular orbit at an inclination of 51.6 degrees or 40,000 lb payloads to a 150 nm circular orbit at a 28.5 degree of inclination. This document will be updated on a timely basis as informatIon becomes available throughout the project.

Comparison of the Effects of Continuous Subcutaneous Insulin Infusion and Add-On Therapy with Sitagliptin in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

Directory of Open Access Journals (Sweden)

Heng Wan

2016-01-01

Full Text Available To identify a new regimen to optimize treatment for patients with newly diagnosed type 2 diabetes (T2DM by short-term continuous subcutaneous insulin infusion (CSII alone. Methods. 60 patients with newly diagnosed T2DM were randomized into two groups (n=30 each and treated for 2 weeks with CSII alone (CSII group or with CSII plus sitagliptin (CSII + Sig group. The glycemic variability of the patients was measured using a continuous glucose monitoring system (CGMS for the last 72 hours. A standard meal test was performed before and after the interventions, and the levels of glycated albumin, fasting glucose, fasting C-peptide, postprandial 2 h blood glucose, and postprandial 2 h C-peptide were examined. Results. Compared with the CSII group, the indicators of glycemic variability, such as the mean amplitude of glycemic excursion (MAGE and the standard deviation of blood glucose (SDBG, were decreased significantly in the CSII + Sig group. The changes before and after treatment in the C-peptide reactivity index (ΔCPI and the secretory unit of islet in transplantation index (ΔSUIT indicated a significant improvement in the CSII + Sig group. Conclusions. Add-on therapy with sitagliptin may be an optimized treatment for patients with newly diagnosed T2DM compared with short-term CSII alone.

Design of ballscrew type CEDM for SMART

International Nuclear Information System (INIS)

Kim, J. H.; Heo, H.; Lee, J. S.; Yu, J. Y.; Kim, D. Y.; Kim, J. I.; Chi, S. K.

2004-01-01

The design characteristics of ballscrew type Control Element Drive Mechanism(CEDM) which is considered to be mounted on integral reactor is described. The ballscrew type CEDM has the design features of fine step control and high load capacity within a nominal full stroke of 680mm. The step moving length of control element assembly by the step motor is 0.25mm which is a requirement for integral reactor with soluble boron-free operation characteristic. The position indicator using reed switch has 4 channels according to the safety grade sensor requirement

Potential beneficial effects of a gluten-free diet in newly diagnosed children with type 1 diabetes

DEFF Research Database (Denmark)

Svensson, Jannet; Sildorf, Stine Møller; Pipper, Christian B.

2016-01-01

Aim: Gluten-free diet has shown promising effects in preventing type 1 diabetes (T1D) in animals as well as beneficial effects on the immune system. Gluten-free diet at diabetes onset may alter the natural course and outcome of autoimmune diseases such as T1D. Methods: In a 12-month study, 15...... children newly diagnosed with T1D were instructed to follow a gluten-free diet. Questionnaires were used to evaluate adherence to the gluten-free diet. Partial remission (PR) was defined by insulin dose-adjusted A1c (IDAA1c) ≤9 or stimulated C-peptide (SCP) >300 pmol/L measured 90 min after a liquid mixed...... meal at the inclusion, six and 12 months after onset. The intervention group was compared with two previous cohorts. Linear mixed models were used to estimate differences between cohorts. Results: After 6 months, more children on a gluten-free diet tended to have SCP values above 300 pmol/L compared...

Multi-Objective Structural Optimization Design of Horizontal-Axis Wind Turbine Blades Using the Non-Dominated Sorting Genetic Algorithm II and Finite Element Method

Directory of Open Access Journals (Sweden)

Jie Zhu

2014-02-01

Full Text Available A multi-objective optimization method for the structural design of horizontal-axis wind turbine (HAWT blades is presented. The main goal is to minimize the weight and cost of the blade which uses glass fiber reinforced plastic (GFRP coupled with carbon fiber reinforced plastic (CFRP materials. The number and the location of layers in the spar cap, the width of the spar cap and the position of the shear webs are employed as the design variables, while the strain limit, blade/tower clearance limit and vibration limit are taken into account as the constraint conditions. The optimization of the design of a commercial 1.5 MW HAWT blade is carried out by combining FEM analysis and a multi-objective evolutionary algorithm under ultimate (extreme flap-wise load and edge-wise load conditions. The best solutions are described and the comparison of the obtained results with the original design is performed to prove the efficiency and applicability of the method.

HORIZONTAL WELL DRILL-IN FLUIDS

Directory of Open Access Journals (Sweden)

Nediljka Gaurina-Međimurec

1998-12-01

Full Text Available Main objective of horizontal driling is to place a drain-hole for a long distance within the pay zone to enhance productivity or injectivity. In drilling horizontal wells, more serious problems appear than in drilling vertical wells. These problems are: poor hole cleaning, excessive torque and drag, hole filling, pipe stucking, wellbore instability, loss of circulation, formation damage, poor cement job, and difficulties at logging jobs. From that reason, successful drilling and production of horizontal well depends largely on the fluid used during drilling and completion phases. Several new fluids, that fulfill some or all of required properties (hole cleaning, cutting suspension, good lubrication, and relative low formation damage, are presented in this paper.

A face detection bias for horizontal orientations develops in middle childhood

Directory of Open Access Journals (Sweden)

Benjamin J Balas

2015-06-01

Full Text Available Faces are complex stimuli that can be described via intuitive facial features like the eyes, nose, and mouth, configural features like the distances between facial landmarks, and features that correspond to computations performed in the early visual system (e.g. oriented edges. With regard to this latter category of descriptors, adult face recognition relies disproportionately on information in specific spatial frequency and orientation bands: Many recognition tasks are performed more accurately when adults have access to mid-range spatial frequencies (8-16 cycles/face and horizontal orientations (Dakin & Watt, 2009. In the current study, we examined how this information bias develops in middle childhood. We recruited children between the ages of 5-10 years old to participate in a simple categorization task that required them to label images according to whether they depicted a face or a house. Critically, children were presented with face and house images comprised either of primarily horizontal orientation energy, primarily vertical orientation energy, or both horizontal and vertical orientation energy. We predicted that any bias favoring horizontal information over vertical should be more evident in faces than in houses, and also that older children would be more likely to show such a bias than younger children. We designed our categorization task to be sufficiently easy that children would perform at near-ceiling accuracy levels, but with variation in response times that would reflect how they rely on different orientations as a function of age and object category. We found that horizontal bias for face detection (but not house detection correlated significantly with age, suggesting an emergent category-specific bias for horizontal orientation energy that develops during middle childhood. These results thus suggest that the tuning of high-level recognition to specific low-level visual features takes take place over several years of visual

Productivity and injectivity of horizontal wells

Energy Technology Data Exchange (ETDEWEB)

Aziz, Khalid

2000-03-06

One of the key issues addressed was pressure drop in long horizontal wells and its influence on well performance. Very little information is available in the literature on flow in pipes with influx through pipe walls. Virtually all of this work has been in small diameter pipes and with single-phase flow. In order to address this problem new experimental data on flow in horizontal and near horizontal wells have been obtained. Experiments were conducted at an industrial facility on typical 6 1/8 ID, 100 feet long horizontal well model. The new data along with available information in the literature have been used to develop new correlations and mechanistic models. Thus it is now possible to predict, within reasonable accuracy, the effect of influx through the well on pressure drop in the well.

Adding liraglutide to the backbone therapy of biguanide in patients with coronary artery disease and newly diagnosed type-2 diabetes (the AddHope2 study)

DEFF Research Database (Denmark)

Anholm, Christian; Kumarathurai, Preman; Klit, Malene S

2014-01-01

INTRODUCTION: Newly diagnosed type 2 diabetes mellitus (T2DM) in patients with coronary artery disease (CAD) more than doubles the risk of death compared with otherwise matched glucose tolerant patients. The biguanide metformin is the drug of choice in treatment of T2DM and has shown to ameliorate...... cardiovascular morbidity in patients with T2DM and myocardial infarction (MI). The incretin hormone, glucagon-like peptide-1 (GLP-1) improves β-cell function, insulin sensitivity and causes weight loss and has been suggested to have beneficial effects on cardiac function. The GLP-1 receptor agonist (GLP-1RA......), liraglutide, is currently used for treatment of T2DM but its potential effect on cardiac function has not been investigated in detail. We hypothesised that liraglutide added to metformin backbone therapy in patients with CAD and newly diagnosed T2DM will improve β-cell function and left ventricular systolic...

Vertical and horizontal access configurations

International Nuclear Information System (INIS)

Spampinato, P.T.

1987-01-01

A number of configuration features and maintenance operations are influenced by the choice of whether a design is based on vertical or horizontal access for replacing reactor components. The features which are impacted most include the first wall/blanket segmentation, the poloidal field coil locations, the toroidal field coil number and size, access port size for in-vessel components, and facilities. Since either configuration can be made to work, the choice between the two is not clear cut because both have certain advantages. It is apparent that there are large cost benefits in the poloidal field coil system for ideal coil locations for high elongation plasmas and marginal savings for the INTOR case. If we assume that a new tokamak design will require a higher plasma elongation, the recommendation is to arrange the poloidal field coils in a cost-effective manner while providing reasonable midplane access for heating interfaces and test modules. If a new design study is not based on a high elongation plasma, it still appears prudent to consider this approach so that in-vessel maintenance can be accomplished without moving very massive structures such as the bulk shield. 10 refs., 29 figs., 3 tabs

Fisher type inequalities for Euclidean t-designs

NARCIS (Netherlands)

Delsarte, Ph.; Seidel, J.J.

1989-01-01

The notion of a Euclidean t-design is analyzed in the framework of appropriate inner product spaces of polynomial functions. Some Fisher type inequalities are obtained in a simple manner by this method. The same approach is used to deal with certain analogous combinatorial designs.

Yaw dynamics of horizontal axis wind turbines

Energy Technology Data Exchange (ETDEWEB)

Hansen, A.C. (Utah Univ., Salt Lake City, UT (United States))

1992-05-01

Designers of a horizontal axis wind turbine yaw mechanism are faced with a difficult decision. They know that if they elect to use a yaw- controlled rotor then the system will suffer increased initial cost and increased inherent maintenance and reliability problems. On the other hand, if they elect to allow the rotor to freely yaw they known they will have to account for unknown and random, though bounded, yaw rates. They will have a higher-risk design to trade-off against the potential for cost savings and reliability improvement. The risk of a yaw-free system could be minimized if methods were available for analyzing and understanding yaw behavior. The complexity of yaw behavior has, until recently, discouraged engineers from developing a complete yaw analysis method. The objectives of this work are to (1) provide a fundamental understanding of free-yaw mechanics and the design concepts most effective at eliminating yaw problems, and (2) provide tested design tools and guidelines for use by free-yaw wind systems manufacturers. The emphasis is on developing practical and sufficiently accurate design methods.

Malignant Hilar Biliary Obstruction: Treatment by Means of Placement of a Newly Designed Y-Shaped Branched Covered Stent

Energy Technology Data Exchange (ETDEWEB)

Yun, Jong Hyouk, E-mail: xell1015@naver.com; Jung, Gyoo-Sik, E-mail: gsjung@medimail.co.kr; Park, Jung Gu [Kosin University College of Medicine, Departments of Diagnostic Radiology (Korea, Republic of); Kang, Byung Chul [Ewha Womans University College of Medicine, Departments of Radiology, Mokdong Hospital (Korea, Republic of); Shin, Dong-Hoon [Kosin University College of Medicine, Departments of General Surgery (Korea, Republic of); Yun, Byung Chul; Lee, Sang Uk [Kosin University College of Medicine, Departments of Internal Medicine (Korea, Republic of)

2016-04-15

PurposeTo evaluate the technical feasibility and clinical efficacy of placement of a newly designed Y-shaped branched covered stent for palliative treatment of malignant hilar biliary obstruction.MethodsFrom June 2011 to September 2014, 34 consecutive patients with malignant hilar biliary obstruction underwent percutaneous placement of a Y-shaped branched covered stent for palliative treatment. Technical and clinical success, complications, cumulative patient survival, and stent patency were evaluated.ResultsStent placement was technically successful in all patients. All patients showed adequate biliary drainage on the follow-up cholangiogram. Mean serum bilirubin level (10.9 mg/dl) decreased significantly 1 week (5.7 mg/dl) and 1 month (2.6 mg/dl) after stent placement (p < 0.01). Complications associated with the procedure included hemobilia (n = 3) and biloma (n = 1). During the mean follow-up period of 225 (range 12–820) days, nine patients (26.5 %) developed stent occlusion caused by tumor overgrowth (n = 8) and sludge (n = 1). Two of them underwent coaxial placement of a second stent with good results. The median survival time was 281 days and median primary stent patency was 337 days. There were no significant differences in the patient survival and stent patency rates in relation to age, sex, or Bismuth type.ConclusionPercutaneous placement of the Y-shaped branched covered stent seems to be technically feasible and clinically effective for palliative treatment of malignant hilar biliary obstruction.

Design and Pitch Angle Optimisation of Horizontal Axis Hydrokinetic Turbine with Constant Tip Speed Ratio

Directory of Open Access Journals (Sweden)

Nigam Suyash

2017-01-01

Full Text Available Booming population and associated energy demands, looming threat of exhaustion of conventional sources of energy and the severe environmental repercussions of the same call for alternate sources of clean energy. Hydrokinetic turbine is one such developing technology which harnesses zero-head free flow of water and affects hydrological ecology minimally. This paper discusses the optimisation of Horizontal Axis Hydrokinetic Turbine (HAHkT blade chord length and twist angle using blade element momentum (BEM theory to achieve a constant optimal angle of attack (AoA, thus maximising the power output. To achieve this while maintaining robustness at the hub end and eliminate cavitation, two different hydrofoils (S832 and E817 are selected. S832 is simulated using ANSYS 14.0 at low (00 and high (150 angles of attack and compared against more widely used NACA 4412 to study flow separation characteristics. This is followed by calculating angles of relative flow, ratios of chord length and subsequently twist angles for each blade element using MATLAB simulations. A blade model is thus developed for visualisation using computer aided designing after obtaining optimal chord lengths and pitch angles.

Weight history of patients with newly diagnosed Type 2 diabetes

DEFF Research Database (Denmark)

Olivarius, N de Fine; Richelsen, B; Siersma, V

2008-01-01

AIMS: To estimate and illustrate how the 10 years of weight change immediately preceding diabetes diagnosis vary with weight at the age of 20 years and with socio-demographic variables, risk factors and comorbidities at diagnosis. METHODS: Data were from a population-based cohort of 1320 persons...... newly diagnosed with diabetes aged > or = 40 years. Patients' weight at diagnosis was measured by the doctor, while patients recalled their weight approximately 1, 5 and 10 years prior to diagnosis and at age 20 years. RESULTS: Median weight gain from age 20 years to diabetes diagnosis at median age 65.......3 years was 14.7 kg (interquartile range 6.0-23.0). Women gained weight more than men, and the lower the weight at age 20 years, the greater the weight gain. The average weight gain from 10 years prior to diabetes diagnosis until diagnosis, however, was only 1 kg and decreased markedly with age. These 10...

Vibration-proof FBR type reactor

International Nuclear Information System (INIS)

Kawamura, Yutaka.

1992-01-01

In a reactor container in an FBR type reactor, an outer building and upper and lower portions of a reactor container are connected by a load transmission device made of a laminated material of rubber and steel plates. Each of the reactor container and the outer building is disposed on a lower raft disposed on a rock by way of a vibration-proof device made of a laminated material of rubber and steel plates. Vibration-proof elements for providing vertical eigen frequency of the vibration-proof system comprising the reactor building and the vibration-proof device within a range of 3Hz to 5Hz are used. That is, the peak of designed acceleration for response spectrum in the horizontal direction of the reactor structural portions is shifted to side of shorter period from the main frequency region of the reactor structure. Alternatively, rigidity of the vibration-proof elements is decreased to shift the peak to the side of long period from the main frequency region. Designed seismic force can be greatly reduced both horizontally and vertically, to reduce the wall thickness of the structural members, improve the plant economy and to ensure the safety against earthquakes. (N.H.)

Type 3 Fimbriae Encoded on Plasmids Are Expressed from a Unique Promoter without Affecting Host Motility, Facilitating an Exceptional Phenotype That Enhances Conjugal Plasmid Transfer

DEFF Research Database (Denmark)

Madsen, Jonas Stenlokke; Riber, Leise; Kot, Witold

2016-01-01

Horizontal gene transfer (HGT), the transmission of genetic material to a recipient that is not the progeny of the donor, is fundamental in bacterial evolution. HGT is often mediated by mobile genetic elements such as conjugative plasmids, which may be in conflict with the chromosomal elements...... of the genome because they are independent replicons that may petition their own evolutionary strategy. Here we study differences between type 3 fimbriae encoded on wild type plasmids and in chromosomes. Using known and newly characterized plasmids we show that the expression of type 3 fimbriae encoded...... on plasmids is systematically different, as MrkH, a c-di-GMP dependent transcriptional activator is not needed for strong expression of the fimbriae. MrkH is required for expression of type 3 fimbriae of the Klebsiella pneumoniae chromosome, wherefrom the fimbriae operon (mrkABCDF) of plasmids is believed...

Horizontal transfers of two types of puf operons among phototrophic members of the Roseobacter clade

Czech Academy of Sciences Publication Activity Database

Koblížek, Michal; Moulisová, Vladimíra; Muroňová, Markéta; Oborník, Miroslav

2015-01-01

Roč. 60, č. 1 (2015), s. 37-43 ISSN 0015-5632 R&D Projects: GA MŠk ED2.1.00/03.0110; GA ČR GAP501/10/0221; GA ČR GBP501/12/G055 Institutional support: RVO:61388971 Keywords : Rosebacter * horizontal transfer * puf operon s Subject RIV: EE - Microbiology, Virology Impact factor: 1.335, year: 2015

CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients

DEFF Research Database (Denmark)

Fløyel, Tina; Brorsson, Caroline; Nielsen, Lotte B

2014-01-01

expression and increased insulin secretion. Additionally, islets from Ctsh(-/-) mice contained less insulin than islets from WT mice. Importantly, the TT genotype was associated with higher daily insulin dose and faster disease progression in newly diagnosed T1D patients, indicating agreement between...

New Correlation Methods of Evaporation Heat Transfer in Horizontal Microfine Tubes

Science.gov (United States)

Makishi, Osamu; Honda, Hiroshi

A stratified flow model and an annular flow model of evaporation heat transfer in horizontal microfin tubes have been proposed. In the stratified flow model, the contributions of thin film evaporation and nucleate boiling in the groove above a stratified liquid were predicted by a previously reported numerical analysis and a newly developed correlation, respectively. The contributions of nucleate boiling and forced convection in the stratified liquid region were predicted by the new correlation and the Carnavos equation, respectively. In the annular flow model, the contributions of nucleate boiling and forced convection were predicted by the new correlation and the Carnavos equation in which the equivalent Reynolds number was introduced, respectively. A flow pattern transition criterion proposed by Kattan et al. was incorporated to predict the circumferential average heat transfer coefficient in the intermediate region by use of the two models. The predictions of the heat transfer coefficient compared well with available experimental data for ten tubes and four refrigerants.

Performance of horizontal versus vertical vapor extraction wells

International Nuclear Information System (INIS)

Birdsell, K.H.; Roseberg, N.D.; Edlund, K.M.

1994-06-01

Vapor extraction wells used for site remediation of volatile organic chemicals in the vadose zone are typically vertical wells. Over the past few years, there has been an increased interest in horizontal wells for environmental remediation. Despite the interest and potential benefits of horizontal wells, there has been little study of the relative performance of horizontal and vertical vapor extraction wells. This study uses numerical simulations to investigate the relative performance of horizontal versus vertical vapor extraction wells under a variety of conditions. The most significant conclusion that can be drawn from this study is that in a homogeneous medium, a single, horizontal vapor extraction well outperforms a single, vertical vapor extraction well (with surface capping) only for long, linear plumes. Guidelines are presented regarding the use of horizontal wells

In-situ bioremediation via horizontal wells

International Nuclear Information System (INIS)

Hazen, T.C.; Looney, B.B.; Enzien, M.; Franck, M.M.; Fliermans, C.B.; Eddy, C.A.

1993-01-01

This project is designed to demonstrate in situ bioremediation of groundwater and sediment contaminated with chlorinated solvents. Indigenous microorganisms were stimulated to degrade TCE, PCE and their daughter products in situ by addition of nutrients to the contaminated zone. In situ biodegradation is a highly attractive technology for remediation because contaminants are destroyed, not simply moved to another location or immobilized, thus decreasing costs, risks, and time, while increasing efficiency and public and regulatory acceptability. Bioremediation has been found to be among the least costly technologies in applications where it will work (Radian 1989). Subsurface soils and water adjacent to an abandoned process sewer line at the SRS have been found to have elevated levels of TCE (Marine and Bledsoe 1984). This area of subsurface and groundwater contamination is the focus of a current integrated demonstration of new remediation technologies utilizing horizontal wells. Bioremediation has the potential to enhance the performance of in situ air stripping as well as offering stand-alone remediation of this and other contaminated sites (Looney et al. 1991). Horizontal wells could also be used to enhance the recovery of groundwater contaminants for bioreactor conversions from deep or inaccessible areas (e.g., under buildings) and to enhance the distribution of nutrient or microbe additions in an in situ bioremediation

Chemical placement in heterogeneous and long reach horizontal wells

Energy Technology Data Exchange (ETDEWEB)

Stalker, Robert; Wahid, Fazrie; Graham, Gordon M.

2006-03-15

The effective placement of chemical squeeze treatments in heterogeneous wells and long reach horizontal wells has proved a significant challenge, with various factors including heterogeneity, crossflow and pressure gradients between otherwise non-communicating zones within the well, all contributing to an uneven placement of the scale squeeze treatment into the reservoir. Current methods to circumvent these problems often rely on extremely expensive coiled tubing operations, staged diversion (temporary shut off) treatments or by designing treatments to deliberately overdose some zones in order to gain placement in other (e.g. low permeability) zones. Moreover for deepwater sub sea horizontal wells the costs associated with ''spot'' treating along the length of horizontal wells by coil tubing tractor operations can often be prohibitively expensive. For other very near well bore treatments such as acid stimulation a number of self diverting strategies including gelled acid treatments, staged viscoelastic surfactant treatments and foams have been applied in field treatments with some success. However the properties which make such treatments applicable for acid stimulation may also make them inappropriate for bullhead scale squeeze treatments. Recent work by the current authors has however indicated the possible benefits of using modified injection fluids to aid uniform scale inhibitor placement in such wells in order to effect more even placement. In summary this paper will describe the various options available for achieving self diversion and describes the potential drawbacks associated with the viscous placement fluids commonly used for acid simulation techniques. In addition, various simulation packages commonly used for scale related calculations are reviewed and their limitations, primarily due to the inherent assumptions made and input parameters used, for modelling squeeze treatments using such modified fluids are described. The paper

A Horizontal Tilt Correction Method for Ship License Numbers Recognition

Science.gov (United States)

Liu, Baolong; Zhang, Sanyuan; Hong, Zhenjie; Ye, Xiuzi

2018-02-01

An automatic ship license numbers (SLNs) recognition system plays a significant role in intelligent waterway transportation systems since it can be used to identify ships by recognizing the characters in SLNs. Tilt occurs frequently in many SLNs because the monitors and the ships usually have great vertical or horizontal angles, which decreases the accuracy and robustness of a SLNs recognition system significantly. In this paper, we present a horizontal tilt correction method for SLNs. For an input tilt SLN image, the proposed method accomplishes the correction task through three main steps. First, a MSER-based characters’ center-points computation algorithm is designed to compute the accurate center-points of the characters contained in the input SLN image. Second, a L 1- L 2 distance-based straight line is fitted to the computed center-points using M-estimator algorithm. The tilt angle is estimated at this stage. Finally, based on the computed tilt angle, an affine transformation rotation is conducted to rotate and to correct the input SLN horizontally. At last, the proposed method is tested on 200 tilt SLN images, the proposed method is proved to be effective with a tilt correction rate of 80.5%.

Implications of Nash Bargaining for Horizontal Industry Integration

OpenAIRE

Richard E. Just; Siddhartha Mitra; Sinaia Netanyahu

2005-01-01

This article shows how horizontal industry integration can arise from transferable asymmetry of technologies and endowments. The Nash bargaining solution suggests that greater technological diversity among coordinating parties yields greater gains from horizontal integration. The framework fits the case where a firm with a superior technology franchises the technology by horizontal integration. The results appear to fit hog production where integration has been primarily horizontal and, in pa...

Workplace Violence and Job Outcomes of Newly Licensed Nurses.

Science.gov (United States)

Chang, Hyoung Eun; Cho, Sung-Hyun

2016-12-01

The purpose of this study was to examine the prevalence of workplace violence toward newly licensed nurses and the relationship between workplace violence and job outcomes. An online survey was conducted of newly licensed registered nurses who had obtained their license in 2012 or 2013 in South Korea and had been working for 5-12 months after first being employed. The sample consisted of 312 nurses working in hospitals or clinics. The Copenhagen Psychosocial Questionnaire II was used to measure violence and nurse job outcomes. Multiple linear and logistic regression analyses were conducted to examine the relationship between violence and job outcomes. Verbal abuse was most prevalent (59.6%), followed by threats of violence (36.9%), physical violence (27.6%), bullying (25.6%), and sexual harassment (22.4%). Approximately three quarters of the nurses had experienced at least one type of violence. The main perpetrators were patients and nurse colleagues, although the distribution of perpetrators varied depending on the type of violence. Bullying had a significant relationship with all four job outcomes (job satisfaction, burnout, commitment to the workplace, and intent to leave), while verbal abuse was associated with all job outcomes except for intent to leave. Violence perpetrated by nurse colleagues had a significant relationship with all four job outcomes, while violence by physicians had a significant inverse relationship with job satisfaction. Workplace violence is experienced by a high percentage of newly licensed nurses, and is associated with their job outcomes. Copyright © 2016. Published by Elsevier B.V.

Shear horizontal wave excitation and reception with shear horizontal piezoelectric wafer active sensor (SH-PWAS)

International Nuclear Information System (INIS)

Kamal, A; Giurgiutiu, V

2014-01-01

This article discusses shear horizontal (SH) guided-waves that can be excited with shear type piezoelectric wafer active sensor (SH-PWAS). The paper starts with a review of state of the art SH waves modelling and their importance in non-destructive evaluation (NDE) and structural health monitoring (SHM). The basic piezoelectric sensing and actuation equations for the case of shear horizontal piezoelectric wafer active sensor (SH-PWAS) with electro-mechanical coupling coefficient d 35 are reviewed. Multiphysics finite element modelling (MP-FEM) was performed on a free SH-PWAS to show its resonance modeshapes. The actuation mechanism of the SH-PWAS is predicted by MP-FEM, and modeshapes of excited structure are presented. The structural resonances are compared with experimental measurements and showed good agreement. Analytical prediction of SH waves was performed. SH wave propagation experimental study was conducted between different combinations of SH-PWAS and regular in-plane PWAS transducers. Experimental results were compared with analytical predictions for aluminium plates and showed good agreement. 2D wave propagation effects were studied by MP-FEM. An analytical model was developed for SH wave power and energy. The normal mode expansion (NME) method was used to account for superpositioning multimodal SH waves. Modal participation factors were presented to show the contribution of every mode. Power and energy transfer between SH-PWAS and the structure was analyzed. Finally, we present simulations of our developed wave power and energy analytical models. (paper)

A new computational method for the detection of horizontal gene transfer events.

Science.gov (United States)

Tsirigos, Aristotelis; Rigoutsos, Isidore

2005-01-01

In recent years, the increase in the amounts of available genomic data has made it easier to appreciate the extent by which organisms increase their genetic diversity through horizontally transferred genetic material. Such transfers have the potential to give rise to extremely dynamic genomes where a significant proportion of their coding DNA has been contributed by external sources. Because of the impact of these horizontal transfers on the ecological and pathogenic character of the recipient organisms, methods are continuously sought that are able to computationally determine which of the genes of a given genome are products of transfer events. In this paper, we introduce and discuss a novel computational method for identifying horizontal transfers that relies on a gene's nucleotide composition and obviates the need for knowledge of codon boundaries. In addition to being applicable to individual genes, the method can be easily extended to the case of clusters of horizontally transferred genes. With the help of an extensive and carefully designed set of experiments on 123 archaeal and bacterial genomes, we demonstrate that the new method exhibits significant improvement in sensitivity when compared to previously published approaches. In fact, it achieves an average relative improvement across genomes of between 11 and 41% compared to the Codon Adaptation Index method in distinguishing native from foreign genes. Our method's horizontal gene transfer predictions for 123 microbial genomes are available online at http://cbcsrv.watson.ibm.com/HGT/.

Endoscopic ultrasound-guided biliary drainage using a newly designed metal stent with a thin delivery system: a preclinical study in phantom and porcine models.

Science.gov (United States)

Minaga, Kosuke; Kitano, Masayuki; Itonaga, Masahiro; Imai, Hajime; Miyata, Takeshi; Yamao, Kentaro; Tamura, Takashi; Nuta, Junya; Warigaya, Kenji; Kudo, Masatoshi

2017-12-08

This study was designed to evaluate the feasibility and safety of a newly designed self-expandable metal stent for endoscopic ultrasound-guided biliary drainage (EUS-BD) when it was delivered via three different stent delivery systems: a 7.5Fr delivery catheter with a bullet-shaped tip (7.5Fr-bullet), a 7Fr catheter with a bullet-shaped tip (7Fr-bullet), or a 7Fr catheter with a tee-shaped tip (7Fr-tee). This experimental study utilized a porcine model of biliary dilatation involving ten pigs. In the animal study, technical feasibility and clinical outcomes of the stent when placed with each of the delivery systems were examined. In addition, a phantom model was used to measure the resistance of these delivery systems to advancement. Phantom experiments showed that, compared with 7Fr-bullet, 7Fr-tee had less resistance force to the advancement of the stent delivery system. EUS-BD was technically successful in all ten pigs. Fistulous tract dilation was necessary in 100% (2/2), 75% (3/4), and 0% (0/4) of the pigs that underwent EUS-BD using 7.5Fr-bullet, 7Fr-bullet, and 7Fr-tee, respectively. There were no procedure-related complications. Our newly designed metal stent may be feasible and safe for EUS-BD, particularly when delivered by 7Fr-tee, because it eliminates the need for fistulous tract dilation.

Hydrodynamic loads of sea waves on horizontal elements of berths with wave quenching chambers

Directory of Open Access Journals (Sweden)

Leshchenko Sergey Vladimirovich

2014-05-01

Full Text Available In the process of hydraulic structures design, in particular berths with wave cancelling structures, which serve to decrease the wave impact on structures, there appears a problem of vertical wave hydrodynamic loads calculation on floor slabs. In the existing normative documents there are no requirements on calculating vertical wave loads on the horizontal floor slabs of open-type structures (enveloping, mooring, approach trestles, etc. and stairs of sloping-staired open-type structures. A mathematical model is proposed for calculation of the vertical wave loads on the floor slab through moorings. The model is based on the theory of jet impact on a solid surface. The width of the wave crest, striking in the overlap of the pier, and its vertical velocity is determined by the linear wave theory. The coefficient of transmission of waves through wave quenching chambers is calculated according to the previously developed methods. Vertical wave loading is adjusted based on the ratio of the wave length and width of the overlay. Model validation is performed according to the hydraulic modelling interaction of waves with through berths in the port of Tuapse. 7 variants of their design were considered. Data mapping mathematical and hydraulic modeling showed them a close match.

A comparative pressure analysis of air flow between horizontal and V-Tail of UAV MALE of NACA0012H with speed variation

OpenAIRE

Riza Rahmat; Kurniawan Dicky; Wicaksono Arif Budi

2018-01-01

NACA0012H is an airfoil type that could be used for Unmanned Aerial Vehicle Medium Altitude Long Endurance. This experiment was used to analyze stress in the surface of Tail of UAV MALE that was caused by air flow. The experiment was conducted using Computational Fluid Dynamics Software. Two designs of tail, horizontal and V-tail, were considered to simulate pressure occurred on the surface of leading edge, chamber and trailing edge. The simulation was developed varying the speed of the UAV M...

Effect of rotor configuration on guyed tower and foundation designs and estimated costs for intermediate site horizontal axis wind turbines

Science.gov (United States)

Frederick, G. R.; Winemiller, J. R.; Savino, J. M.

1982-01-01

Three designs of a guyed cylindrical tower and its foundation for an intermediate size horizontal axis wind turbine generator are discussed. The primary difference in the three designs is the configuration of the rotor. Two configurations are two-blade rotors with teetering hubs - one with full span pitchable blades, the other with fixed pitch blades. The third configuration is a three-bladed rotor with a rigid hub and fixed pitch blades. In all configurations the diameter of the rotor is 38 meters and the axis of rotation is 30.4 meters above grade, and the power output is 200 kW and 400 kW. For each configuration the design is based upon for the most severe loading condition either operating wind or hurricane conditions. The diameter of the tower is selected to be 1.5 meters (since it was determined that this would provide sufficient space for access ladders within the tower) with guy rods attached at 10.7 meters above grade. Completing a design requires selecting the required thicknesses of the various cylindrical segments, the number and diameter of the guy rods, the number and size of soil anchors, and the size of the central foundation. The lower natural frequencies of vibration are determined for each design to ensure that operation near resonance does not occur. Finally, a cost estimate is prepared for each design. A preliminary design and cost estimate of a cantilever tower (cylindrical and not guyed) and its foundation is also presented for each of the three configurations.

Analysis of tree stand horizontal structure using random point field methods

Directory of Open Access Journals (Sweden)

O. P. Sekretenko

2015-06-01

Full Text Available This paper uses the model approach to analyze the horizontal structure of forest stands. The main types of models of random point fields and statistical procedures that can be used to analyze spatial patterns of trees of uneven and even-aged stands are described. We show how modern methods of spatial statistics can be used to address one of the objectives of forestry – to clarify the laws of natural thinning of forest stand and the corresponding changes in its spatial structure over time. Studying natural forest thinning, we describe the consecutive stages of modeling: selection of the appropriate parametric model, parameter estimation and generation of point patterns in accordance with the selected model, the selection of statistical functions to describe the horizontal structure of forest stands and testing of statistical hypotheses. We show the possibilities of a specialized software package, spatstat, which is designed to meet the challenges of spatial statistics and provides software support for modern methods of analysis of spatial data. We show that a model of stand thinning that does not consider inter-tree interaction can project the size distribution of the trees properly, but the spatial pattern of the modeled stand is not quite consistent with observed data. Using data of three even-aged pine forest stands of 25, 55, and 90-years old, we demonstrate that the spatial point process models are useful for combining measurements in the forest stands of different ages to study the forest stand natural thinning.

Horizontal alternating steam drive process for the Orinoco heavy oil belt in eastern Venezuela

Energy Technology Data Exchange (ETDEWEB)

Edgar A. Fernandez R.; Bashbush, J.L. [Schlumberger, Sugar Land, TX (United States)

2008-10-15

Horizontal alternating steam drive (HASD) processes use single horizontal wells that cyclically switch between injection and production phases. The steam chambers generated by the wells are laterally driven by the pressure differentials created by adjacent producers to form a sweeping front between the wells. This feasibility study assessed the use of HASD processes at a heavy oil reservoir in Venezuela. The study used numerical simulations from a representative reservoir with a 5-horizontal well array to asses the HASD recovery technique under various scenarios. Sensitivity analyses were also conducted to consider the positioning of the horizontal well placement in the reservoir column; different injection sequences; variations in the duration of injection cycles; injection rates; and the lengths of the horizontal reach of the wells. Results of the study suggested that HASD is a suitable alternative for reservoirs with sands in the 20 foot to 50 foot thickness range. HASD achieved average recovery factors of above 20 per cent over a 15 year period, and required fewer wells than steam assisted gravity drainage (SAGD) processes. It was concluded that the wells must be designed to consider the additional thermal stresses resulting the repeated injection and production cycles associated with HASD processes. The 6 refs., 2 tabs., 16 figs.

Ancient horizontal gene transfer from bacteria enhances biosynthetic capabilities of fungi.

Directory of Open Access Journals (Sweden)

Imke Schmitt

Full Text Available Polyketides are natural products with a wide range of biological functions and pharmaceutical applications. Discovery and utilization of polyketides can be facilitated by understanding the evolutionary processes that gave rise to the biosynthetic machinery and the natural product potential of extant organisms. Gene duplication and subfunctionalization, as well as horizontal gene transfer are proposed mechanisms in the evolution of biosynthetic gene clusters. To explain the amount of homology in some polyketide synthases in unrelated organisms such as bacteria and fungi, interkingdom horizontal gene transfer has been evoked as the most likely evolutionary scenario. However, the origin of the genes and the direction of the transfer remained elusive.We used comparative phylogenetics to infer the ancestor of a group of polyketide synthase genes involved in antibiotic and mycotoxin production. We aligned keto synthase domain sequences of all available fungal 6-methylsalicylic acid (6-MSA-type PKSs and their closest bacterial relatives. To assess the role of symbiotic fungi in the evolution of this gene we generated 24 6-MSA synthase sequence tags from lichen-forming fungi. Our results support an ancient horizontal gene transfer event from an actinobacterial source into ascomycete fungi, followed by gene duplication.Given that actinobacteria are unrivaled producers of biologically active compounds, such as antibiotics, it appears particularly promising to study biosynthetic genes of actinobacterial origin in fungi. The large number of 6-MSA-type PKS sequences found in lichen-forming fungi leads us hypothesize that the evolution of typical lichen compounds, such as orsellinic acid derivatives, was facilitated by the gain of this bacterial polyketide synthase.

Design and Implementation of a CO2 Flood Utilizing Advanced Reservoir Characterization and Horizontal Injection Wells In a Shallow Shelf Carbonate Approaching Waterflood Depletion, Class II

Energy Technology Data Exchange (ETDEWEB)

Wier, Don R. Chimanhusky, John S.; Czirr, Kirk L.; Hallenbeck, Larry; Gerard, Matthew G.; Dollens, Kim B.; Owen, Rex; Gaddis, Maurice; Moshell, M.K.

2002-11-18

The purpose of this project was to economically design an optimum carbon dioxide (CO2) flood for a mature waterflood nearing its economic abandonment. The original project utilized advanced reservoir characterization and CO2 horizontal injection wells as the primary methods to redevelop the South Cowden Unit (SCU). The development plans; project implementation and reservoir management techniques were to be transferred to the public domain to assist in preventing premature abandonment of similar fields.

Exercise recommendations in patients with newly diagnosed fibromyalgia.

Science.gov (United States)

Wilson, Brad; Spencer, Horace; Kortebein, Patrick

2012-04-01

To evaluate exercise recommendations in patients newly diagnosed with fibromyalgia. A retrospective chart review. A public university rheumatology clinic. Patients newly diagnosed with fibromyalgia (N = 122). Frequency and type of exercise recommendations. The mean (standard deviation) age of these patients with fibromyalgia was 45 ± 12 years; 91% were women. Exercise was recommended as part of the documented treatment plan in 47% of these patients (57/122); only 3 patients had a documented contraindication for exercise. Aquatic exercise was most frequently recommended (56% [32/57]), followed by combined aquatic-aerobic exercise (26% [15/57]), and, infrequently, aerobic exercise only (5% [3/57]); only 7% of these patients (4/57) were referred for physical therapy. The primary method of communication was verbal discussion (94% [54/57]). Although there is well-documented evidence that exercise is beneficial for patients with fibromyalgia, we found that less than half of patients with newly diagnosed fibromyalgia in our study were provided recommendations to initiate an exercise program as part of their treatment plan. Further investigation of these findings are warranted, including evaluation of other university and community rheumatology practices as well as that of other physicians caring for patients with fibromyalgia. However, our findings indicate that there appears to be an opportunity to provide more specific and practical education regarding the implementation of an exercise regimen for patients with newly diagnosed fibromyalgia. Physiatrists may be particularly well suited to manage the exercise component of patients with fibromyalgia because of their specialized training in exercise prescription. Copyright © 2012 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.

Storage Tanks - Selection Of Type, Design Code And Tank Sizing

International Nuclear Information System (INIS)

Shatla, M.N; El Hady, M.

2004-01-01

The present work gives an insight into the proper selection of type, design code and sizing of storage tanks used in the Petroleum and Process industries. In this work, storage tanks are classified based on their design conditions. Suitable design codes and their limitations are discussed for each tank type. The option of storage under high pressure and ambient temperature, in spherical and cigar tanks, is compared to the option of storage under low temperature and slight pressure (close to ambient) in low temperature and cryogenic tanks. The discussion is extended to the types of low temperature and cryogenic tanks and recommendations are given to select their types. A study of pressurized tanks designed according to ASME code, conducted in the present work, reveals that tanks designed according to ASME Section VIII DIV 2 provides cost savings over tanks designed according to ASME Section VIII DlV 1. The present work is extended to discuss the parameters that affect sizing of flat bottom cylindrical tanks. The analysis shows the effect of height-to-diameter ratio on tank instability and foundation loads

Hydrajet fracturing: an effective method for placing many fractures in openhole horizontal wells

Energy Technology Data Exchange (ETDEWEB)

Surjaatmadja, J. B.; Grundmann, S. R.; McDaniel, B.; Deeg, W. F. J.; Brumley, J. L.; Swor, L. C.

1998-12-31

A new method for openhole horizontal well fracturing that combines hydrajetting and fracturing techniques, which was developed on the basis of Bernoulli`s theorem, is described. This theorem has been effectively proven in many applications such as jet pumps, additive injection systems and jet aircraft engines. By using this method, operators can position a jetting tool, without the use of sealing elements, at the exact point where fracture is required. The method also permits the use of multiple fractures in the same well, which can be spaced evenly or unevenly as prescribed by the fracturing program. Damage can be avoided by placing hundreds of small fractures in a long horizontal section, or operators can use acid and/or propped sand techniques to place a combination of two fracture types in the well. The paper describes the basic principles of horizontal hydrajet fracturing, and elements of a laboratory model which was developed to demonstrate the effectiveness of the method.

Effect of metformin therapy on the levels of certain adipose tissue hormones and mediators of nonspecific generalized inflammation in patients with newly diagnosed type 2 diabetes

Directory of Open Access Journals (Sweden)

A.M. Urbanovych

2015-05-01

Full Text Available The aim of the study was to investigate the influence of the drug metformin on the levels of adipose tissue hormones and generalized nonspecific mediators of inflammation in type 2 diabetes. 38 patients with newly diagnosed type 2 diabetes were followed up before and after 12 months of hypoglycemic monotherapy with glucophage. The results indicate that the normalization of carbohydrate metabolism indices and decreased body weight of patients in the presence of the therapy is due not only to direct effects of metformin in improving glucose uptake by peripheral tissues, but by the ability of the drug to modulate adipocytokine secretion.

Spondylolysis and the sacro-horizontal angle in athletes

International Nuclear Information System (INIS)

Swaerd, L.; Hellstroem, M.; Jacobsson, B.; Peterson, L.; Sahlgrenska Sjukhuset, Goeteborg; King Faisal Specialist Hospital and Research Centre, Riyadh

1989-01-01

The frequency of spondylolysis and the relationship between spondylolysis and the sacro-horizontal angle in 143 athletes and 30 non-athletes is reported. Athletes had a larger sacro-horizontal angle than non-athletes. The sacro-horizontal angle was larger in athletes with spondylolysis as compared with those without. An increased incidence of spondylolysis with an increased angle was demonstrated. It is suggested that an increased sacro-horizontal angle may predispose to spondylolysis, especially in combination with the high mechanical loads sustained in certain sports. (orig.)

Spondylolysis and the sacro-horizontal angle in athletes

Energy Technology Data Exchange (ETDEWEB)

Swaerd, L.; Hellstroem, M.; Jacobsson, B.; Peterson, L. (Oestra Sjukhuset, Goeteborg (Sweden). Dept. of Orthopaedics; Sahlgrenska Sjukhuset, Goeteborg (Sweden). Dept. of Diagnostic Radiology; King Faisal Specialist Hospital and Research Centre, Riyadh (Saudi Arabia). Dept. of Radiology)

The frequency of spondylolysis and the relationship between spondylolysis and the sacro-horizontal angle in 143 athletes and 30 non-athletes is reported. Athletes had a larger sacro-horizontal angle than non-athletes. The sacro-horizontal angle was larger in athletes with spondylolysis as compared with those without. An increased incidence of spondylolysis with an increased angle was demonstrated. It is suggested that an increased sacro-horizontal angle may predispose to spondylolysis, especially in combination with the high mechanical loads sustained in certain sports. (orig.).

Modeling, design, packing and experimental analysis of liquid-phase shear-horizontal surface acoustic wave sensors

Science.gov (United States)

Pollard, Thomas B

using uniform-electrode and shear-horizontal mode configurations on potassium-niobate, langasite, and quartz substrates. Optimum configurations are determined yielding maximum sensitivity. Results show mode propagation-loss and sensitivity to viscosity are correlated by a factor independent of substrate material. The analysis is useful for designing devices meeting sensitivity and signal level requirements. A novel, rapid and precise microfluidic chamber alignment/bonding method was developed for SAW platforms. The package is shown to have little effect on device performance and permits simple macrofluidic interfacing. Lastly, prototypes were designed, fabricated, and tested for viscosity and biosensor applications; results show ability to detect as low as 1% glycerol in water and surface-bound DNA crosslinking.

Low serum cartonectin/CTRP3 concentrations in newly diagnosed type 2 diabetes mellitus: in vivo regulation of cartonectin by glucose.

Directory of Open Access Journals (Sweden)

Bo Ban

Full Text Available OBJECTIVES: Cartonectin is a novel adipokine of the C1q complement/TNF-related protein (CTRP superfamily, with glucose lowering effects, anti-inflammatory and cardio-protective properties. We sought to investigate circulating cartonectin concentrations in subjects with type 2 diabetes mellitus (T2DM as well as age and BMI matched control subjects. We also examined the effects of a 2 hour 75 g oral glucose tolerance test (OGTT on serum cartonectin concentrations in T2DM subjects. DESIGN: Cross-sectional study [newly diagnosed (first discovery, not on any treatments T2DM (n = 47 and control (n = 63 subjects]. Serum cartonectin was measured by ELISA. RESULTS: Serum cartonectin concentrations were significantly lower in patients with T2DM compared to controls (P0.05. There were no significant correlations in T2DM subjects (n = 47. In control subjects (n = 63, serum cartonectin was significantly negatively correlated with CRP, and significantly positively correlated with insulin, HOMA-IR and leptin. However, when subjected to multiple regression analysis, none of these variables were predictive of serum cartonectin (P>0.05. Finally, serum cartonectin concentrations were significantly lower in T2DM subjects after a 2 hour 75 g OGTT (P<0.01. CONCLUSIONS: Cartonectin may serve as a novel biomarker for the prediction and early diagnosis of T2DM patients. Furthermore, cartonectin and/or pharmacological agents that increase circulating cartonectin levels can represent a new therapeutic field in the treatment of T2DM patients. Further research is needed to clarify these points.

Drug usage patterns and treatment costs in newly-diagnosed type 2 diabetes mellitus cases, 2007 vs 2012: findings from a large US healthcare claims database analysis.

Science.gov (United States)

Weng, W; Liang, Y; Kimball, E S; Hobbs, T; Kong, S; Sakurada, B; Bouchard, J

2016-07-01

Objective To explore trends in demographics, comorbidities, anti-diabetic drug usage, and healthcare utilization costs in patients with newly-diagnosed type 2 diabetes mellitus (T2DM) using a large US claims database. Methods For the years 2007 and 2012, Truven Health Marketscan Research Databases were used to identify adults with newly-diagnosed T2DM and continuous 12-month enrollment with prescription benefits. Variables examined included patient demographics, comorbidities, inpatient utilization patterns, healthcare costs (inpatient and outpatient), drug costs, and diabetes drug claim patterns. Results Despite an increase in the overall database population between 2007-2012, the incidence of newly-diagnosed T2DM decreased from 1.1% (2007) to 0.65% (2012). Hyperlipidemia and hypertension were the most common comorbidities and increased in prevalence from 2007 to 2012. In 2007, 48.3% of newly-diagnosed T2DM patients had no claims for diabetes medications, compared with 36.2% of patients in 2012. The use of a single oral anti-diabetic drug (OAD) was the most common diabetes medication-related claim (46.2% of patients in 2007; 56.7% of patients in 2012). Among OAD monotherapy users, metformin was the most commonly used and increased from 2007 (74.7% of OAD monotherapy users) to 2012 (90.8%). Decreases were observed for sulfonylureas (14.1% to 6.2%) and thiazolidinediones (7.3% to 0.6%). Insulin, predominantly basal insulin, was used by 3.9% of patients in 2007 and 5.3% of patients in 2012. Mean total annual healthcare costs increased from $13,744 in 2007 to $15,175 in 2012, driven largely by outpatient services, although costs in all individual categories of healthcare services (inpatient and outpatient) increased. Conversely, total drug costs per patient were lower in 2012 compared with 2007. Conclusions Despite a drop in the rate of newly-diagnosed T2DM from 2007 to 2012 in the US, increased total medical costs and comorbidities per individual patient suggest that

comparative evaluation of pressure distribution between horizontal

African Journals Online (AJOL)

user

This paper presents comparative analysis between the pressure behavior of ... Green and source function were used to evaluate the performance of horizontal well and ..... Superscript. ' derivative. D = dimensionless. h = horizontal. = change.

Utility Independent Privacy Preserving Data Mining - Horizontally Partitioned Data

Directory of Open Access Journals (Sweden)

E Poovammal

2010-06-01

Full Text Available Micro data is a valuable source of information for research. However, publishing data about individuals for research purposes, without revealing sensitive information, is an important problem. The main objective of privacy preserving data mining algorithms is to obtain accurate results/rules by analyzing the maximum possible amount of data without unintended information disclosure. Data sets for analysis may be in a centralized server or in a distributed environment. In a distributed environment, the data may be horizontally or vertically partitioned. We have developed a simple technique by which horizontally partitioned data can be used for any type of mining task without information loss. The partitioned sensitive data at 'm' different sites are transformed using a mapping table or graded grouping technique, depending on the data type. This transformed data set is given to a third party for analysis. This may not be a trusted party, but it is still allowed to perform mining operations on the data set and to release the results to all the 'm' parties. The results are interpreted among the 'm' parties involved in the data sharing. The experiments conducted on real data sets prove that our proposed simple transformation procedure preserves one hundred percent of the performance of any data mining algorithm as compared to the original data set while preserving privacy.

Radon in soil gas in the metropolitan region of Belo Horizonte, Brazil

International Nuclear Information System (INIS)

Teixeira, Giane Gariglio; Rocha, Zildete

2007-01-01

Radon, the natural radioactive gas is produced by the radioactive decay of uranium and thorium which are ubiquitous, specially in rock and soil. By diffusion and convection. Radon migrate from the rocks and to the groundwater and to the soil and from them the radon migrate through fissures, pipes and hales to the surface. Measurements were carried out in the Metropolitan Region of Belo Horizonte, whose greatest part of the in habitants occupies the great pre cambrian unit of the Iron Quadrangle of Minas Gerais denominated 'Granitic Gneissic Complex', composed of Archean rocks of age between 3,2 Ga and 2,6 Ga. The part in which occurs in the municipal area of Belo Horizonte was denominated as Complexo Belo Horizonte, whose most characteristics rocks named Gneiss Belo Horizonte. The soil gas radon concentrations were determined by using a samples and a continuos flow through ionization chamber detector AlphaGUARD PQ2000PRO - Genitron Instruments GmbH in a Instrumental Neutron Activation Analysis). Most results of radon concentration soil gas were in the range 10 kBq/m 3 to 50 kBq/m 3 . This values, according to the established Swedish Criteria are normal risk values. For soils classified as normal risk require 'radon protective construction', but the necessity of mitigation actions will depend on other factors, for example the soil permeability and rock type. (author)

Patients newly diagnosed with clinical type 2 diabetes during oral glucocorticoid treatment and observed for 14 years: all-cause mortality and clinical developments

DEFF Research Database (Denmark)

Olivarius, Niels de Fine; Siersma, Volkert Dirk; Dyring-Andersen, B.

2011-01-01

and sex and to 1.39 (0.92-2.11, p = 0.12, n = 1086) when risk factors, complications and cancer were added to the model. Apart from differences in age and overweight, patients in this relatively small sample of those diagnosed with clinical type 2 diabetes during GC treatment were comparable at diagnosis...... treatment. A population-based sample of 1369 people newly diagnosed with clinical type 2 diabetes underwent a clinical examination at diagnosis, and surviving patients were followed up 6 and 14 years later. Patients receiving oral GC treatment at diagnosis were compared with the other patients. Of 1369......Chronic exposure to glucocorticoids (GCs) has many side effects including glucose intolerance and diabetes and may accelerate the occurrence of cardiovascular disease and increase mortality. We studied the 14-year clinical development of diabetes in patients diagnosed with diabetes during GC...

Optimal hydraulic design of new-type shaft tubular pumping system

International Nuclear Information System (INIS)

Zhu, H G; Zhang, R T; Zhou, J R

2012-01-01

Based on the characteristics of large flow rate, low-head, short annual operation time and high reliability of city flood-control pumping stations, a new-type shaft tubular pumping system featuring shaft suction box, siphon-type discharge passage with vacuum breaker as cutoff device was put forward, which possesses such advantages as simpler structure, reliable cutoff and higher energy performance. According to the design parameters of a city flood control pumping station, a numerical computation model was set up including shaft-type suction box, siphon-type discharge passage, pump impeller and guide vanes. By using commercial CFD software Fluent, RNG κ-ε turbulence model was adopted to close the three-dimensional time-averaged incompressible N-S equations. After completing optimal hydraulic design of shaft-type suction box, and keeping the parameters of total length, maximum width and outlet section unchanged, siphon-type discharge passages of three hump locations and three hump heights were designed and numerical analysis on the 9 hydraulic design schemes of pumping system were proceeded. The computational results show that the changing of hump locations and hump heights directly affects the internal flow patterns of discharge passages and hydraulic performances of the system, and when hump is located 3.66D from the inlet section and hump height is about 0.65D (D is the diameter of pump impeller), the new-type shaft tubular pumping system achieves better energy performances. A pumping system model test of the optimal designed scheme was carried out. The result shows that the highest pumping system efficiency reaches 75.96%, and when at design head of 1.15m the flow rate and system efficiency were 0.304m 3 /s and 63.10%, respectively. Thus, the validity of optimal design method was verified by the model test, and a solid foundation was laid for the application and extension of the new-type shaft tubular pumping system.

How should we discuss genetic testing with women newly diagnosed with breast cancer? Design and implementation of a randomized controlled trial of two models of delivering education about treatment-focused genetic testing to younger women newly diagnosed with breast cancer

Directory of Open Access Journals (Sweden)

Watts Kaaren J

2012-07-01

Full Text Available Abstract Background Germline BRCA1 and BRCA2 mutation testing offered shortly after a breast cancer diagnosis to inform women’s treatment choices - treatment-focused genetic testing ‘TFGT’ - has entered clinical practice in specialist centers and is likely to be soon commonplace in acute breast cancer management, especially for younger women. Yet the optimal way to deliver information about TFGT to younger women newly diagnosed with breast cancer is not known, particularly for those who were not suspected of having a hereditary breast cancer syndrome prior to their cancer diagnosis. Also, little is known about the behavioral and psychosocial impact or cost effectiveness of educating patients about TFGT. This trial aims to examine the impact and efficiency of two models of educating younger women newly diagnosed with breast cancer about genetic testing in order to provide evidence for a safe and effective future clinical pathway for this service. Design/methods In this non-inferiority randomized controlled trial, 140 women newly diagnosed with breast cancer (aged less than 50 years are being recruited from nine cancer centers in Australia. Eligible women with either a significant family history of breast and/or ovarian cancer or with other high risk features suggestive of a mutation detection rate of > 10% are invited by their surgeon prior to mastectomy or radiotherapy. After completing the first questionnaire, participants are randomized to receive either: (a an educational pamphlet about genetic testing (intervention or (b a genetic counseling appointment at a family cancer center (standard care. Each participant is offered genetic testing for germline BRCA mutations. Decision-related and psychosocial outcomes are assessed over 12 months and include decisional conflict (primary outcome;uptake of bilateral mastectomy and/or risk-reducing salpingo-oophorectomy; cancer-specific- and general distress; family involvement in decision

INVESTIGATION OF ADMIXTURE SEDIMENTATION IN THE HORIZONTAL SETTLER

Directory of Open Access Journals (Sweden)

V. A. Kozachyna

2016-08-01

Full Text Available Purpose.Sedimentation by gravity is the most common and extensively applied treatment process for the removal of solids from water and wastewater and it has been used for over one hundred years. Sedimentation tanks are one of the major parts of a treatment plant especially in purification of turbid flows. Horizontal settlers are mainly used for purification of high quantity of water. In these tanks, the low speed turbid water will flow through the length of the tank and suspended particle have enough time to settle. Finding new and useful methods for calculating and increasing hydraulic efficiency of horizontal settlers is the objective of many theoretical, experimental and numerical studies.But currently used models and methods in Ukraine do not allow taking into account geometrical form and various design features. In this paper the numerical model was developed to evaluate the effectiveness of horizontal settler with modified structure. Methodology. Numerical model is based on: 1 equation of viscous fluid dynamics; 2 mass transfer equation. For numerical simulation the finite difference schemes are used. The numerical calculation is carried out on a rectangular grid. For the formation of the computational domain markers are used. Findings.The model allows obtaining the purification process in the settler with different form and different configuration of baffles. Originality. A new approach to investigate the mass transfer process in horizontal settler was proposed. This approach is based on the developed CFD model. The fluid dynamics model was used for the numerical investigation of flows and waste waters purification. To investigate influence of baffles on settler efficiency physical experiment was carried out. Practical value.The developed model has more capacity than the existing models in Ukraine. The developed model allows computing quickly the efficiency of water purification in settlers. The model is not computationally expensive

Practicing on Newly Dead

Directory of Open Access Journals (Sweden)

Jewel Abraham

2015-07-01

Full Text Available A newly dead cadaver simulation is practiced on the physical remains of the dead before the onset of rigor mortis. This technique has potential benefits for providing real-life in-situ experience for novice providers in health care practices. Evolving ethical views in health care brings into question some of the ethical aspects associated with newly dead cadaver simulation in terms of justification for practice, autonomy, consent, and the need of disclosure. A clear statement of policies and procedures on newly dead cadaver simulation has yet to be implemented. Although there are benefits and disadvantages to an in-situ cadaver simulation, such practices should not be carried out in secrecy as there is no compelling evidence that suggests such training as imperative. Secrecy in these practices is a violation of honor code of nursing ethics. As health care providers, practitioners are obliged to be ethically honest and trustworthy to their patients. The author explores the ethical aspects of using newly dead cadaver simulation in training novice nursing providers to gain competency in various lifesaving skills, which otherwise cannot be practiced on a living individual. The author explores multiple views on cadaver simulation in relation to ethical theories and practices such as consent and disclosure to family.

Comprehensive Deformation Analysis of a Newly Designed Ni-Free Duplex Stainless Steel with Enhanced Plasticity by Optimizing Austenite Stability

Science.gov (United States)

Moallemi, Mohammad; Zarei-Hanzaki, Abbas; Eskandari, Mostafa; Burrows, Andrew; Alimadadi, Hossein

2017-08-01

A new metastable Ni-free duplex stainless steel has been designed with superior plasticity by optimizing austenite stability using thermodynamic calculations of stacking fault energy and with reference to literature findings. Several characterization methods comprising optical microscopy, magnetic phase measurements, X-ray diffraction (XRD) and electron backscattered diffraction were employed to study the plastic deformation behavior and to identify the operating plasticity mechanisms. The results obtained show that the newly designed duplex alloy exhibits some extraordinary mechanical properties, including an ultimate tensile strength of 900 MPa and elongation to fracture of 94 pct due to the synergistic effects of transformation-induced plasticity and twinning-induced plasticity. The deformation mechanism of austenite is complex and includes deformation banding, strain-induced martensite formation, and deformation-induced twinning, while the ferrite phase mainly deforms by dislocation slip. Texture analysis indicates that the Copper and Rotated Brass textures in austenite (FCC phase) and {001} texture in ferrite and martensite (BCC phases) are the main active components during tensile deformation. The predominance of these components is logically related to the strain-induced martensite and/or twin formation.

Horizontally staggered lightguide solar concentrator with lateral displacement tracking for high concentration applications.

Science.gov (United States)

Ma, Hongcai; Wu, Lin

2015-07-10

We present the design of a horizontally staggered lightguide solar concentrator with lateral displacement tracking for high concentration applications. This solar concentrator consists of an array of telecentric primary concentrators, a horizontally staggered lightguide layer, and a vertically tapered lightguide layer. The primary concentrator is realized by two plano-aspheric lenses with lateral movement and maintains a high F-number over an angle range of ±23.5°. The results of the simulations show that the solar concentrator achieves a high concentration ratio of 500× with ±0.5° of acceptance angle by a single-axis tracker and dual lateral translation stages.

The horizontal plane appearances of scoliosis

DEFF Research Database (Denmark)

Illés, Tamás S.; Burkus, Máté; Somoskeőy, Szabolcs

2017-01-01

Purpose: A posterior-anterior vertebral vector is proposed to facilitate visualization and understanding of scoliosis. The aim of this study was to highlight the interest of using vertebral vectors, especially in the horizontal plane, in clinical practice. Methods: We used an EOS two-/three-dimen......Purpose: A posterior-anterior vertebral vector is proposed to facilitate visualization and understanding of scoliosis. The aim of this study was to highlight the interest of using vertebral vectors, especially in the horizontal plane, in clinical practice. Methods: We used an EOS two...... cases of a normal spine and a thoracic scoliosis are presented. Results: For a normal spine, vector projections in the transverse plane are aligned with the posterior-anterior anatomical axis. For a scoliotic spine, vector projections in the horizontal plane provide information on the lateral...... decompensation of the spine and the lateral displacement of vertebrae. In the horizontal plane view, vertebral rotation and projections of the sagittal curves can also be analyzed simultaneously. Conclusions: The use of posterior-anterior vertebral vector facilitates the understanding of the 3D nature...

Human Studies of Vertical and Horizontal Alveolar Ridge Augmentation Comparing Different Types of Bone Graft Materials: A Systematic Review.

Science.gov (United States)

Chavda, Suraj; Levin, Liran

2018-02-01

Alveolar ridge augmentation can be completed with various types of bone augmentation materials (autogenous, allograft, xenograft, and alloplast). Currently, autogenous bone is labeled as the "gold standard" because of faster healing times and integration between native and foreign bone. No systematic review has currently determined whether there is a difference in implant success between various bone augmentation materials. The purpose of this article was to systematically review comparative human studies of vertical and horizontal alveolar ridge augmentation comparing different types of bone graft materials (autogenous, allograft, xenograft, and alloplast). A MEDLINE search was conducted under the 3 search concepts of bone augmentation, dental implants, and alveolar ridge augmentation. Studies pertaining to socket grafts or sinus lifts were excluded. Case reports, small case series, and review papers were excluded. A bias assessment tool was applied to the final articles. Overall, 219 articles resulted from the initial search, and 9 articles were included for final analysis. There were no discernible differences in implant success between bone augmentation materials. Generally, patients preferred nonautogenous bone sources as there were fewer hospital days, less pain, and better recovery time. Two articles had industrial support; however, conclusions of whether that support influenced the outcomes could not be determined. Future comparative studies should compare nonautogenous bone sources and have longer follow-up times.

The physical environment and patients' activities and care: A comparative case study at three newly built stroke units.

Science.gov (United States)

Anåker, Anna; von Koch, Lena; Sjöstrand, Christina; Heylighen, Ann; Elf, Marie

2018-04-20

To explore and compare the impact of the physical environment on patients' activities and care at three newly built stroke units. Receiving care in a stroke unit instead of in a general ward reduces the odds of death, dependency and institutionalized care. In stroke units, the design of the physical environment should support evidence-based care. Studies on patients' activities in relation to the design of the physical environment of stroke units are scarce. This work is a comparative descriptive case study. Patients (N = 55) who had a confirmed diagnosis of stroke were recruited from three newly built stroke units in Sweden. The units were examined by non-participant observation using two types of data collection: behavioural mapping analysed with descriptive statistics and field note taking analysed with deductive content analysis. Data were collected from April 2013 - December 2015. The units differed in the patients' levels of physical activity, the proportion of the day that patients spent with health professionals and family presence. Patients were more physically active in a unit with a combination of single and multi-bed room designs than in a unit with an entirely single-room design. Stroke units that were easy to navigate and offered variations in the physical environment had an impact on patients' activities and care. Patients' activity levels and interactions appeared to vary with the design of the physical environments of stroke units. Stroke guidelines focused on health status assessments, avoidance of bed-rest and early rehabilitation require a supportive physical environment. © 2018 The Authors. Journal of Advanced Nursing Published by John Wiley & Sons Ltd.

Thermal performance of plate-type loop thermosyphon at sub-atmospheric pressures

International Nuclear Information System (INIS)

Tsoi, Vadim; Chang, Shyy Woei; Chiang Kuei Feng; Huang, Chuan Chin

2011-01-01

This experimental study examines the thermal performance of a newly devised plate-type two-phase loop thermosyphon with cooling applications to electronic boards of telecommunication systems. The evaporation section is configured as the inter-connected multi channels to emulate the bridging boiling mechanism in pulsating thermosyphon. Two thermosyphon plates using water as the coolant with filling ratios (FR) of 0.22 and 0.32 are tested at sub-atmospheric pressures. The vapor-liquid flow images as well as the thermal resistances and effective spreading thermal conductivities are individually measured for each thermosyphon test plate at various heating powers. The high-speed digital images of the vapor-liquid flow structures reveal the characteristic boiling phenomena and the vapor-liquid circulation in the vertical thermosyphon plate, which assist to explore the thermal physics for this type of loop thermosyphon. The bubble agglomeration and pumping action in the inter-connected boiling channels take place at metastable non-equilibrium conditions, leading to the intermittent slug flows with a pulsation character. Such hybrid loop-pulsating thermosyphon permits the vapor-liquid circulation in the horizontal plate. Thermal resistances and spreading thermal conductivities detected from the present thermosyphon plates; the vapor chamber flat plate heat pipe and the copper plate at free and forced convective cooling conditions with both vertical and horizontal orientations are cross-examined. In most telecommunication systems and units, the electrical boards are vertical so that the thermal performance data on the vertical thermosyphon are most relevant to this particular application. - Highlights: → We examine thermal performances of plate-type loop thermosyphon. → Thermal resistances and spreading conductivities are examined. → Bubble agglomeration in inter-connected boiling channels generates intermittent slug flows with pulsations. → Boiling instability

Bottom-type scattering layers and equatorial spread F

Directory of Open Access Journals (Sweden)

D. L. Hysell

2004-12-01

Full Text Available Jicamarca radar observations of bottom-type coherent scattering layers in the post-sunset bottomside F-region ionosphere are presented and analyzed. The morphology of the primary waves seen in radar images of the layers supports the hypothesis of kudeki+bhattacharyya-1999 that wind-driven gradient drift instabilities are operating. In one layer event when topside spread F did not occur, irregularities were distributed uniformly in space throughout the layers. In another event when topside spread F did eventually occur, the irregularities within the pre-existing bottom-type layers were horizontally clustered, with clusters separated by about 30km. The same horizontal periodicity was evident in the radar plumes and large-scale irregularities that emerged later in the event. We surmise that horizontal periodicity in bottom-type layer irregularity distribution is indicative of large-scale horizontal waves in the bottomside F-region that may serve as seed waves for large-scale Rayleigh Taylor instabilities. Key words. Ionosphere (equatorial ionosphere; ionospheric irregularties; plasma waves and instabilities

Prediction And Performance Assessments of External Horizontal Global Illuminance of Measured Data from Port-Harcourt, Nigeria

International Nuclear Information System (INIS)

Akingbade, F.O.A.

2002-01-01

This paper reports the measurements and analysis of external horizontal global illuminance for Port-Harcourt, Nigeria. A set of empirical expressions were derived from seasonal and yearly variations of horizontal global illuminance against solar altitude. The model derived from the study performed better compared with two other models proposed for the area from other studies conducted elsewhere. The results presented here serves to develop the base for reliable localized day lighting data to be used in building designs in the area

Horizontal drilling in Miocene thin sand of Lake Maracaibo

Energy Technology Data Exchange (ETDEWEB)

Partidas, C. [PDVSA Exploration and Production (Venezuela)

1998-12-31

Horizontal drilling in the mature Lake Maracaibo field in Venezuela as a means of stimulating production are discussed. The Miocene sand where the horizontal well technology was applied, presented a number of intervals of unconsolidated sand of varied continuity, pay intervals at ten to twenty feet thickness, and reservoir pressures mostly at hydrostatic or below hydrostatic values. This paper evaluates a horizontal drilling program in the Lagunallis Lago Production Unit of Maracaibo, involving 91 wells to date (since 1995). When assessed in economic terms, results indicate that horizontal wells are a better economic alternative than vertical wells. The same results also showed that drainage from thin sand reservoirs resulted in better production with horizontal well technology than production from vertical wells. Payout was less than two years for 50 per cent of the horizontal wells while 40 per cent had payouts of between two and four years. Profit to investment ratio was greater than two in the case of about 70 per cent of the horizontal wells drilled in 1996. 2 tabs., 10 figs.

Development of a large area, curved two-dimensional detector for single-crystal neutron diffraction studies

International Nuclear Information System (INIS)

Moon, Myung-Kook; Lee, Chang-Hee; Kim, Shin-Ae; Noda, Yukio

2013-01-01

A new type of two-dimensional curved position-sensitive neutron detector has been developed for a high-throughput single-crystal neutron diffractometer, which was designed to cover 110° horizontally and 56° vertically. The prototype curved detector covering 70° horizontally and 45° vertically was first developed to test the technical feasibility of the detector parameters, the internal anode and cathode structures for the curved shape, technical difficulties in the assembly procedure, and so on. Then, based on this experience, a full-scale curved detector with twice the active area of the prototype was fabricated with newly modified anode and cathode planes and optimized design parameters in terms of mechanical and electric properties. The detector was installed in a dedicated diffractometer at the ST3 beam port of the research reactor HANARO. In this paper, the fabrication and application of the prototype and a new larger-area curved position-sensitive neutron detector for single crystal diffraction is presented

The performance studies of DKDP crystals grown by a rapid horizontal growth method

Science.gov (United States)

Xie, Xiaoyi; Qi, Hongji; Wang, Bin; Wang, Hu; Chen, Duanyang; Shao, Jianda

2018-04-01

A deuterated potassium dihydrogen phosphate (DKDP) crystal with about 70% deuterium level was grown by a rapid horizontal growth method with independent design equipment, which includes a continuous filtration system. The cooling program during crystal growth was designed according to a self-developed software to catch the size of growing crystal in real time. The crystal structure, optical performance and laser induced damage threshold (LIDT) of this DKDP crystal were investigated in this paper. The deuterium concentration of the crystal was confirmed by the neutron diffraction technique, which was effective and available in determining a complete range of deuteration level. The dielectric property was measured to evaluate the perfection of the lattice. The transmittance and LIDT were carried out further to evaluate the optical and functional properties of this DKDP crystal grown in the rapid horizontal growth technique. All of the detailed characterization for DKDP figured out that the 70% deuterated KDP crystal grown in this way had relatively good qualities.

Upgraded Features of Newly Constructed Fuel Assembly Mechanical Characterization Test Facility in KAERI

Energy Technology Data Exchange (ETDEWEB)

Lee, Kang Hee; Kang, Heung Seok; Yoon, Kyung Ho; Kim, Hyung Kyu; Lee, Young Ho; Kim, Soo Ho; Yang, Jae Ho [KAERI, Daejeon (Korea, Republic of)

2016-05-15

Fuel assembly mechanical characterization test facility (FAMeCT) in KAERI is newly constructed with upgraded functional features such as increased loading capacity, under-water vibration testing and severe earthquake simulation for extended fuel design guideline. The facility building is compactly designed in the scale of 3rd floor building and has regions for assembly-wise mechanical test equipment, dynamic load (seismic) simulating test system, small scale hydraulic loop and component wise test equipment. Figure 1 shows schematic regional layout of the facility building. Mechanical test platform and system is designed to increase loading capacity for axial compression test. Structural stability of the support system of new upper core plate simulator is validated through a limit case functional test. Fuel assembly mechanical characterization test facility in KAERI is newly constructed and upgraded with advanced functional features such as uprated loading capacity, under-water vibration testing and severe earthquake simulation for extended fuel design guideline. This paper briefly introduce the test facility construction and scope of the facility and is focused on the upgraded design features of the facility. Authors hope to facilitate the facility more in the future and collaborate with the industry.

Horizontally-connected ZnO-graphene hybrid films for multifunctional devices

Energy Technology Data Exchange (ETDEWEB)

Lim, Yi Rang [Thin Film Materials Research Center, Korea Research Institute of Chemical Technology, Yuseong Post Office Box 107, Daejeon 305-600 (Korea, Republic of); School of Semiconductor and Chemical Engineering, Semiconductor Physics Research Center (SPRC), Chonbuk National University, Jeonju 561-756 (Korea, Republic of); Song, Wooseok; Lee, Young Bum; Kim, Seong Ku; Han, Jin Kyu; Myung, Sung; Lee, Sun Sook; An, Ki-Seok [Thin Film Materials Research Center, Korea Research Institute of Chemical Technology, Yuseong Post Office Box 107, Daejeon 305-600 (Korea, Republic of); Choi, Chel-Jong [School of Semiconductor and Chemical Engineering, Semiconductor Physics Research Center (SPRC), Chonbuk National University, Jeonju 561-756 (Korea, Republic of); Lim, Jongsun, E-mail: jslim@krict.re.kr [Thin Film Materials Research Center, Korea Research Institute of Chemical Technology, Yuseong Post Office Box 107, Daejeon 305-600 (Korea, Republic of)

2016-08-30

Highlights: • We designed horizontally-connected ZnO and graphene hybrid nanofilms with improved flexibility for multifunctional nanodevices including high performance TFTs. • The photocurrent on-off ratio, response time, and recovery time of the hybrid photodetectors were estimated to be 10{sup 2}, 34 s, and 27 s, respectively. The photocurrent from the hybrid photodetector decreased only by two-fold, whereas a significant decrease in photocurrent by two orders of magnitude was observed from the ZnO thin film based photodetectors after 10{sup 5} cycles of 5-mm radius bending. • The hybrid thin film transistors exhibited unipolar n-channel transistor behavior with electron mobility of 68.7 cm{sup 2}/V s and on-off ratio of 10{sup 7}. - Abstract: Here we designed horizontally-connected ZnO thin films and graphene in order to combine advantages of ZnO thin films, which are high on/off ratio and photo responsivity, and the superior mobility and sensitivity of graphene for applications in thin film transistors (TFTs) and flexible photodetectors. To synthesize the ZnO/graphene hybrid films, a 70-nm-thick ZnO thin film with a uniformly flat surface deposited by the atomic layer deposition process was horizontally connected with highly crystalline monolayer graphene grown by thermal chemical vapor deposition. The photocurrent on-off ratio, response time, and recovery time of the hybrid photodetectors were estimated to be 10{sup 2}, 34 s, and 27 s, respectively. The photocurrent from the hybrid photodetector decreased only by two-fold, whereas a significant decrease in photocurrent by two orders of magnitude was observed from the ZnO thin film based photodetectors after 10{sup 5} cycles of 5-mm radius bending. The hybrid TFT exhibited unipolar n-channel transistor behavior with electron mobility of 68.7 cm{sup 2}/V s and on-off ratio of 10{sup 7}.

Benefits of a horizontal well in sandstone waterflood

International Nuclear Information System (INIS)

Hansen, K.L.

1992-01-01

This is a case study which describes the planning and results of a horizontal well in a shallow Wilcox sandstone waterflood unit in central Louisiana. The Tremont H-13-1 was OXY USA Inc.'s first horizontal well. Analysis will include examination of the selection criteria, planning, execution, completion, and production. A variety of well and field data is presented and reviewed to access the value of this information as it applies towards other applications. The Cruse Waterflood Unit is a 2100 ft. Wilcox formation in central Louisiana. Production improvements have been 500% or greater for the horizontal well versus adjacent vertical wells. The horizontal well paid out in less than 4 months Results from this well indicate that not only was this project an economic success, but that other fields will similar conditions can be produced in a more profitable manner with horizontal wells

Newly graduated nurses' use of knowledge sources

DEFF Research Database (Denmark)

Voldbjerg, Siri Lygum; Grønkjaer, Mette; Sørensen, Erik Elgaard

2016-01-01

AIM: To advance evidence on newly graduated nurses' use of knowledge sources. BACKGROUND: Clinical decisions need to be evidence-based and understanding the knowledge sources that newly graduated nurses use will inform both education and practice. Qualitative studies on newly graduated nurses' use...... underscoring progression in knowledge use and perception of competence and confidence among newly graduated nurses. CONCLUSION: The transition phase, feeling of confidence and ability to use critical thinking and reflection, has a great impact on knowledge sources incorporated in clinical decisions....... The synthesis accentuates that for use of newly graduated nurses' qualifications and skills in evidence-based practice, clinical practice needs to provide a supportive environment which nurtures critical thinking and questions and articulates use of multiple knowledge sources....

Diabetic ketoacidosis characteristics and differences in type 1 versus type 2 diabetes patients

International Nuclear Information System (INIS)

Rashid, M.O.; Sheikh, A.; Salam, A.; Farooq, S.; Kiran, Z.; Islam, N.

2017-01-01

Background: Diabetes is undoubtedly one of the most challenging health problems of the 21st century. It is well known that diabetes once develop can lead to several complications. Diabetic ketoacidosis (DKA) is one of the life-threatening complications of diabetes. This study was designed to determine the frequency of DKA in diabetes patients and find out the clinical and biochemical determinants of DKA. Methods: This descriptive study was conducted at Aga Khan University Hospital (AKUH) Karachi, Pakistan from January 2010 to February 2016. All known or newly diagnosed diabetic patients of >16 years of age irrespective of gender and type of diabetes were included. Information regarding patient’s demographics, presenting symptoms, precipitating causes of DKA, biochemical profiles and outcome at the time of discharge was collected. Results: Majority (54.7%) had moderate and 12.4% had severe DKA at presentation. Previous history of DKA was found higher in type 1 diabetes patients (T1DM) (14%) as compare to (4%) type 2 diabetes patients (T2DM) (p<0.05). DKA severity was observed more (12%) in newly diagnosed (T1DM) (p<0.05). Comorbidities were found more (81%) in (T2DM) (p<0.05) Mortality was also observed higher in Type 2 diabetes patients (p<0.05). Conclusion: Majority of the diabetics had moderate to severe DKA at presentation. Mortality and morbidity related with DKA was found considerably higher among patients with T2DM while infection, myocardial infarction and stroke found as triggering factors in these patients. (author)

Study on time properties of newly type inorganic scintillator cerium fluoride (CeF3)

International Nuclear Information System (INIS)

Hu Mengchun; Zhou Dianzhong; Guo Cun; Ye Wenying

2003-01-01

CeF 3 is a newly fast time response inorganic scintillator, the time characteristics of which, developed in recent country in nearly year were studied in our works. The time characteristics are rise time, FWHM time and fall time for fast pulse radiation source. As the same time, authors have calculated and used the formula of pulse method gain to the decay time constant of crystal shining, the decay time constant measured is the same to the results of foreign references

Comparison of Efficacy and Safety of Lispro and Aspart Evaluated by Continuous Glucose Monitoring System in Patients with Newly Diagnosed Type 2 Diabetes

Directory of Open Access Journals (Sweden)

Bing-li Liu

2018-01-01

Full Text Available Objective. To compare the effect of the rapid-acting insulin analogues (RAIAs aspart (NovoRapid and lispro (Prandilin on glycemic variations by continuous glucose monitoring system (CGMS in patients within newly diagnosed type 2 diabetes mellitus (T2DM receiving continuous subcutaneous insulin infusion (CSII and metformin intensive therapy. Methods. This is a single-blind randomized controlled trial. A total of 110 patients with newly diagnosed T2DM and with hemoglobin A1c (HbA1c% above 9% was hospitalized and randomly divided into two groups: group Asp (NovoRapid group and group Lis (Prandilin group. They all received CSII and metformin therapy. Treatments were maintained for 2-3 weeks after the glycaemic target was reached. C-peptide and insulin and fructosamine were determined. CGMS was continuously applied for 4 days after reaching the glycemic target. Results. There were no significant differences in daily dosages of insulin, fasting plasma C-P and 2 h postprandial C-P and insulin, and fructosamine at the baseline and endpoint between the groups Asp and Lis. No significant differences were seen in the 24 h mean amplitude of glycemic excursions (MAGE, 24 h mean blood glucose (MBG, the standard deviation of the MBG (SDBG, fasting blood glucose, number of glycemic excursion (NGE, and the incidence of hypoglycemia between the two groups. Similarly, no significant differences were found in areas under the curve (AUC of glucose above 10.0 mmol/L or the decremental area over the curve (AOC of glucose below 3.9 mmol/L between the two groups. Conclusions. Lispro and aspart had the similar ability to control the glycemic variations in patients with newly diagnosed T2DM. This study was registered with ClinicalTrials.gov, number ChiCTR-IPR-17010338.

Soliton wave model for simulating the slug formation in vertical-to-horizontal partially blocked pipes

International Nuclear Information System (INIS)

Nihan Onder; Alberto Teyssedou; Danila Roubtsov

2005-01-01

Full text of publication follows: In CANDU reactors the fuel channels are connected to inlet and outlet headers by feeder-pipes that consist of vertical and horizontal legs. In some feeders, orifices are installed for flow adjustment. During a postulated Loss of Coolant Accidents, the emergency cooling water injected into the inlet and outlet headers enters the fuel channels through the feeder pipes. Steam produced in the feeders and in the fuel channels may flow in the direction opposite to that of the water, thereby creating vertical to horizontal Counter-Current Flow (CCF). The rate at which the cooling water enters the fuel channel may be substantially limited by the flooding phenomena that entrains the water in the same direction as the steam flow. Steam flowing in the direction opposite to the cooling water can bring about the formation of slug flow. Long slugs of liquid moving at relatively high speed are transported back towards the headers by the steam. This phenomenon substantially reduces the amount of cooling water that can reach the reactor core. We conducted CCF experiments using a vertical-to-horizontal test section connected by 90 deg. elbows, with an orifice installed in the horizontal leg. Four different orifices were used to carry out the experiments. We have observed that soliton-type waves generated close to the elbow propagate in the horizontal leg towards the orifice, where a partial reflection takes place. Without an orifice, the soliton waves are reflected from the second elbow. The reflected waves move in the opposite direction to that of the incident wave. Since soliton-type waves are periodically generated, the incident and reflected waves interfere at some place in the horizontal leg. If the amplitude of the interference wave is high enough, the bridging of the tubes occur, which generates the slugs. During the experiments the water and air flow rates, pressures and void fraction distributions were measured. The slug propagation

Variability of the inclination of anatomic horizontal reference planes of the craniofacial complex in relation to the true horizontal line in orthognathic patients.

Science.gov (United States)

Zebeib, Ameen M; Naini, Farhad B

2014-12-01

The purpose of this study was to assess the reliability of the Frankfort horizontal (FH), sella-nasion horizontal, and optic planes in terms of their variabilities in relation to a true horizontal line in orthognathic surgery patients. Thirty-six consecutive presurgical orthognathic patients (13 male, 23 female; age range, 16-35 years; 30 white, 6 African Caribbean) had lateral cephalometric radiographs taken in natural head position, with a plumb line orientating the true vertical line, and the true horizontal line perpendicular to the true vertical. The inclinations of the anatomic reference planes were compared with the true horizontal. The FH plane was found to be on average closest to the true horizontal, with a mean of -1.6° (SD, 3.4°), whereas the sella-nasion horizontal and the optic plane had means of 2.1° (SD, 5.1°) and 3.2° (SD, 4.7°), respectively. The FH showed the least variability of the 3 anatomic planes. The ranges of variability were high for all anatomic planes: -8° to 8° for the FH, -8° to 15° for the sella-nasion horizontal, and -6° to 13° for the optic plane. No significant differences were found in relation to patients' sex, skeletal patterns, or ethnic backgrounds. The clinically significant variability in the inclinations of anatomic reference planes in relation to the true horizontal plane makes their use unreliable in orthognathic patients. Copyright © 2014 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.

Soot and liquid-phase fuel distributions in a newly designed optically accessible DI diesel engine

Science.gov (United States)

Dec, J. E.; Espey, C.

1993-10-01

Two-dimensional (2-D) laser-sheet imaging has been used to examine the soot and liquid-phase fuel distributions in a newly designed, optically accessible, direct-injection diesel engine of the heavy-duty size class. The design of this engine preserves the intake port geometry and basic dimensions of a Cummins N-series production engine. It also includes several unique features to provide considerable optical access. Liquid-phase fuel and soot distribution studies were conducted at a medium speed (1,200 rpm) using a Cummins closed-nozzle fuel injector. The scattering was used to obtain planar images of the liquid-phase fuel distribution. These images show that the leading edge of the liquid-phase portion of the fuel jet reaches a maximum length of 24 mm, which is about half the combustion bowl radius for this engine. Beyond this point virtually all the fuel has vaporized. Soot distribution measurements were made at a high load condition using three imaging diagnostics: natural flame luminosity, 2-D laser-induced incandescence, and 2-D elastic scattering. This investigation showed that the soot distribution in the combusting fuel jet develops through three stages. First, just after the onset of luminous combustion, soot particles are small and nearly uniformly distributed throughout the luminous region of the fuel jet. Second, after about 2 crank angle degrees a pattern develops of a higher soot concentration of larger sized particles in the head vortex region of the jet and a lower soot concentration of smaller sized particles upstream toward the injector. Third, after fuel injection ends, both the soot concentration and soot particle size increase rapidly in the upstream portion of the fuel jet.

Development of new type concrete for spent fuel storage cask

International Nuclear Information System (INIS)

Shimojo, J.; Mantani, K.; Owaki, E.; Sugihara, Y.; Hata, A.; Shimono, M.; Taniuchi, H.

2004-01-01

Heat resistant concrete has been developed to make it possible to design a new type cask that has been designed on the same concept of metal cask technologies for use in high temperature conditions. The allowable temperature of conventional concrete is limited to less than 100 degrees Celsius because most of its moisture is free water and therefore hydrogen, which is effective for neutron shielding, can be easily lost. Our newly developed concrete uses chemically bonded water and as a result can be used under high temperatures

Development of new type concrete for spent fuel storage cask

Energy Technology Data Exchange (ETDEWEB)

Shimojo, J.; Mantani, K. [Kobe Steel, Ltd., Hyogo (Japan); Owaki, E.; Sugihara, Y.; Hata, A.; Shimono, M. [Taisei Corp., Tokyo (Japan); Taniuchi, H. [Transnuclear, Ltd., Tokyo (Japan)

2004-07-01

Heat resistant concrete has been developed to make it possible to design a new type cask that has been designed on the same concept of metal cask technologies for use in high temperature conditions. The allowable temperature of conventional concrete is limited to less than 100 degrees Celsius because most of its moisture is free water and therefore hydrogen, which is effective for neutron shielding, can be easily lost. Our newly developed concrete uses chemically bonded water and as a result can be used under high temperatures.

Risk of newly detected infections and cervical abnormalities in women seropositive for naturally acquired human papillomavirus type 16/18 antibodies: analysis of the control arm of PATRICIA.

Science.gov (United States)

Castellsagué, Xavier; Naud, Paulo; Chow, Song-Nan; Wheeler, Cosette M; Germar, Maria Julieta V; Lehtinen, Matti; Paavonen, Jorma; Jaisamrarn, Unnop; Garland, Suzanne M; Salmerón, Jorge; Apter, Dan; Kitchener, Henry; Teixeira, Julio C; Skinner, S Rachel; Limson, Genara; Szarewski, Anne; Romanowski, Barbara; Aoki, Fred Y; Schwarz, Tino F; Poppe, Willy A J; Bosch, F Xavier; de Carvalho, Newton S; Peters, Klaus; Tjalma, Wiebren A A; Safaeian, Mahboobeh; Raillard, Alice; Descamps, Dominique; Struyf, Frank; Dubin, Gary; Rosillon, Dominique; Baril, Laurence

2014-08-15

We examined risk of newly detected human papillomavirus (HPV) infection and cervical abnormalities in relation to HPV type 16/18 antibody levels at enrollment in PATRICIA (Papilloma Trial Against Cancer in Young Adults; NCT00122681). Using Poisson regression, we compared risk of newly detected infection and cervical abnormalities associated with HPV-16/18 between seronegative vs seropositive women (15-25 years) in the control arm (DNA negative at baseline for the corresponding HPV type [HPV-16: n = 8193; HPV-18: n = 8463]). High titers of naturally acquired HPV-16 antibodies and/or linear trend for increasing antibody levels were significantly associated with lower risk of incident and persistent infection, atypical squamous cells of undetermined significance or greater (ASCUS+), and cervical intraepithelial neoplasia grades 1/2 or greater (CIN1+, CIN2+). For HPV-18, although seropositivity was associated with lower risk of ASCUS+ and CIN1+, no association between naturally acquired antibodies and infection was demonstrated. Naturally acquired HPV-16 antibody levels of 371 (95% confidence interval [CI], 242-794), 204 (95% CI, 129-480), and 480 (95% CI, 250-5756) EU/mL were associated with 90% reduction of incident infection, 6-month persistent infection, and ASCUS+, respectively. Naturally acquired antibodies to HPV-16, and to a lesser extent HPV-18, are associated with some reduced risk of subsequent infection and cervical abnormalities associated with the same HPV type. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.

Horizontal bridges in polar dielectric liquids

Science.gov (United States)

Woisetschläger, Jakob; Wexler, Adam D.; Holler, Gert; Eisenhut, Mathias; Gatterer, Karl; Fuchs, Elmar C.

2012-01-01

When a high-voltage direct-current is applied to two beakers filled with polar liquid dielectrica like water or methanol, a horizontal bridge forms between the two beakers. By repeating a version of Pellat's experiment, it is shown that a horizontal bridge is stable by the action of electrohydrodynamic pressure. Thus, the static and dynamic properties of the phenomenon called a `floating water bridge' can be explained by the gradient of Maxwell pressure, replenishing the liquid within the bridge against any drainage mechanism. It is also shown that a number of liquids can form stable and long horizontal bridges. The stability of such a connection, and the asymmetry in mass flow through such bridges caused by the formation of ion clouds in the vicinity of the electrodes, is also discussed by two further experiments.

Superiority of radiobinding assay over ELISA for detection of IAAs in newly diagnosed type I diabetic children

International Nuclear Information System (INIS)

Levy-Marchal, C.; Bridel, M.P.; Sodoyez-Goffaux, F.; Koch, M.; Tichet, J.; Czernichow, P.; Sodoyez, J.C.

1991-01-01

Liquid- or solid-phase assays have been used for insulin autoantibody (IAA) determination, and the method of IAA measurement has not been standardized. IAAs were determined by radiobinding assay (RBA) and enzyme-linked immunosorbent assay (ELISA) in two large age-matched groups of nondiabetic and newly diagnosed insulin-dependent (type I) diabetic children. Positivity for IAA by RBA (greater than or equal to nondiabetic mean + 3SD) was 2 of 178 (1.1%) and 55 of 173 (32%) in nondiabetic and diabetic children, respectively. Prevalence of IAA by RBA was significantly higher in the youngest age-group (63% between 0-4 yr). Positivity for IAA by ELISA was 1 of 178 (0.6%) and 8 of 169 (4.7%) in nondiabetic and diabetic children, respectively. Concordance rates between both assays were 0 of 3 (0%) in control subjects and 5 of 58 (8.6%) in diabetic children. We conclude that RBA is more appropriate than ELISA for IAA detection at the onset of the disease. In addition, because available data suggest that IAAs detected by RBA only are high-affinity antibodies, it is tempting to speculate that IAAs reflect a mature immune reaction against endogenous insulin

The successful use of transverse hydraulic fractures from horizontal wellbores

Energy Technology Data Exchange (ETDEWEB)

Crosby, D. G.; Yang, Z.; Rahman, S. S. [New South Wales Univ., NSW (Australia)

1998-12-31

Since a significant proportion of the world`s recoverable hydrocarbon resources exist in reservoirs possessing permeabilities of less than one milli-Darcy (mD), some form of permeability enhancement or stimulation is necessary if the hydrocarbons are to be exploited economically. Multi-stage, transversely fractured horizontal wellbores are shown to have the potential to greatly increase production from low permeability formations. To overcome the problems caused by near-wellbore tortuosity, common to wells with multiple fracturing from the same perforated interval, a criterion was devised which predicts the wellbore pressures to initiate secondary multiple transverse hydraulic fractures in close proximity to primary fractures. The criterion, confirmed by laboratory experiments, demonstrates that transversely fractured horizontal wellbores have limited capacities to resist the initiation of multiple fractures from adjacent perforations. This characteristic can be used in designing hydraulic fracture treatments to establish injection pressure limits or threshold pressures, above which additional multiple fractures will initiate and propagate from the wellbore. 23 refs., 1 tab., 10 figs.

Problems in the development of high-rank CBM horizontal wells in the Fanzhuang–Zhengzhuang Block in the Qinshui Basin and countermeasures

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Yongping Zhang

2017-11-01

Full Text Available Coal reservoirs in the Qinshui Basin are characterized by high thermal evolution degree, low permeability, low reservoir pressure, lower gas saturation and strong heterogeneity, so its coalbed methane (CBM development is quite difficult. In this paper, the development practice of high-rank CBM horizontal wells in the Fanzhuang–Zhengzhuang Block was analyzed in terms of geological and engineering factors to clarify the productivity influencing factors, suitable geological conditions and potential tapping countermeasures of multi-lateral horizontal wells. It is shown that the reasons for the low development efficiency of multi-lateral horizontal wells are divided into three types. The first one is geological factor, such as encountering low CBM content areas or faults. The second is engineering factor, such as drilling fluid plugging, drilling collapse, drainage collapse and dust coal blockage. The third is the combination of both factors. It is concluded that encountering low CBM content areas and faults, collapse and blockage are the main reasons for the low production of multi-lateral horizontal wells in the Zhengzhuang–Fanzhuang Block, with the CBM content higher than 20 m3/t, the ratio of critical desorption pressure and reservoir pressure higher than 0.7 and vitrinite reflectance (Ro higher than 3.8. The prerequisite for an open-hole horizontal well in this area to produce CBM at a high rate is that the well lies in the tensile stress zone. Finally, the countermeasures to tap the potential of some inefficient wells were put forward. First, the inefficient wells which are blocked with dust coal or collapsed in the later stage should be stimulated based on classifications. And second, it is necessary to explore new types of horizontal wells so as to deal with borehole collapse and continue the operation in the later stage by using tree-like roof horizontal wells, single-lateral horizontal wells with casing or screen completion and fish

Implementing vertical and horizontal engineering students' integration and assessment of consequence academic achievement

Science.gov (United States)

Al-Zubaidy, Sarim; Abdulaziz, Nidhal; Dashtpour, Reza

2012-08-01

Recent scholarship references indicate that integration of the student body can result in an enhanced learning experience for students and also greater satisfaction. This paper reports the results of a case study whereby mechanical engineering students studying at a newly established branch campus in Dubai of a British university were exposed to vertical and horizontal integration. Different activities have been embedded to ensure that students integrated and worked together with their peers and colleagues at different levels. The implemented processes and practices led to improved academic achievements, which were better than those of a similar cohort of students where no effort had been made to integrate. The analysis revealed that cooperative learning and the degree of academic support provided by teachers are positively and directly correlated with academic as well as the students' own sense of personal achievement. The results are discussed in light of previous research and with reference to the cultural context of the study.

Biomechanical Property of a Newly Designed Assembly Locking Compression Plate: Three-Dimensional Finite Element Analysis

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Jiang-Jun Zhou

2017-01-01

Full Text Available In this study, we developed and validated a refined three-dimensional finite element model of middle femoral comminuted fracture to compare the biomechanical stability after two kinds of plate fixation: a newly designed assembly locking compression plate (NALCP and a locking compression plate (LCP. CT data of a male volunteer was converted to middle femoral comminuted fracture finite element analysis model. The fracture was fixated by NALCP and LCP. Stress distributions were observed. Under slow walking load and torsion load, the stress distribution tendency of the two plates was roughly uniform. The anterolateral femur was the tension stress area, and the bone block shifted toward the anterolateral femur. Maximum stress was found on the lateral border of the number 5 countersink of the plate. Under a slow walking load, the NALCP maximum stress was 2.160e+03 MPa and the LCP was 8.561e+02 MPa. Under torsion load, the NALCP maximum stress was 2.260e+03 MPa and the LCP was 6.813e+02 MPa. Based on those results of finite element analysis, the NALCP can provide adequate mechanical stability for comminuted fractures, which would help fixate the bone block and promote bone healing.

Newly graduated nurses' empowerment regarding professional competence and other work-related factors.

Science.gov (United States)

Kuokkanen, Liisa; Leino-Kilpi, Helena; Numminen, Olivia; Isoaho, Hannu; Flinkman, Mervi; Meretoja, Riitta

2016-01-01

Although both nurse empowerment and competence are fundamental concepts of describing newly graduated nurses' professional development and job satisfaction, only few studies exist on the relationship between these concepts. Therefore, the purpose of this study was to determine how newly graduated nurses assess their empowerment and to clarify professional competence compared to other work-related factors. A descriptive, cross-sectional and correlational design was applied. The sample comprised newly graduated nurses (n = 318) in Finland. Empowerment was measured using the 19-item Qualities of an Empowered Nurse scale and the Nurse Competence Scale measured nurses' self-assessed generic competence. In addition to demographic data, the background data included employment sector (public/private), job satisfaction, intent to change/leave job, work schedule (shifts/business hours) and assessments of the quality of care in the workplace. The data were analysed statistically by using Spearman's correlation coefficient as well as the One-Way and Multivariate Analysis of Variance. Cronbach's alpha coefficient was used to estimate the internal consistency. Newly graduated nurses perceived their level of empowerment and competence fairly high. The association between nurse empowerment and professional competence was statistically significant. Other variables correlating positively to empowerment included employment sector, age, job satisfaction, intent to change job, work schedule, and satisfaction with the quality of care in the work unit. The study indicates competence had the strongest effect on newly graduated nurses' empowerment. New graduates need support and career opportunities. In the future, nurses' further education and nurse managers' resources for supporting and empowering nurses should respond to the newly graduated nurses' requisites for attractive and meaningful work.

Type III CRISPR-Cas systems can provide redundancy to counteract viral escape from type I systems.

Science.gov (United States)

Silas, Sukrit; Lucas-Elio, Patricia; Jackson, Simon A; Aroca-Crevillén, Alejandra; Hansen, Loren L; Fineran, Peter C; Fire, Andrew Z; Sánchez-Amat, Antonio

2017-08-17

CRISPR-Cas-mediated defense utilizes information stored as spacers in CRISPR arrays to defend against genetic invaders. We define the mode of target interference and role in antiviral defense for two CRISPR-Cas systems in Marinomonas mediterranea . One system (type I-F) targets DNA. A second system (type III-B) is broadly capable of acquiring spacers in either orientation from RNA and DNA, and exhibits transcription-dependent DNA interference. Examining resistance to phages isolated from Mediterranean seagrass meadows, we found that the type III-B machinery co-opts type I-F CRISPR-RNAs. Sequencing and infectivity assessments of related bacterial and phage strains suggests an 'arms race' in which phage escape from the type I-F system can be overcome through use of type I-F spacers by a horizontally-acquired type III-B system. We propose that the phage-host arms race can drive selection for horizontal uptake and maintenance of promiscuous type III interference modules that supplement existing host type I CRISPR-Cas systems.

Integrated hydraulic booster/tool string technology for unfreezing of stuck downhole strings in horizontal wells

Science.gov (United States)

Tian, Q. Z.

2017-12-01

It is common to use a jarring tool to unfreeze stuck downhole string. However, in a horizontal well, influenced by the friction caused by the deviated section, jarring effect is poor; on the other hand, the forcing point can be located in the horizontal section by a hydraulic booster and the friction can be reduced, but it is time-consuming and easy to break downhole string using a large-tonnage and constant pull force. A hydraulic booster - jar tool string has been developed for unfreezing operation in horizontal wells. The technical solution involves three elements: a two-stage parallel spring cylinder structure for increasing the energy storage capacity of spring accelerators; multiple groups of spring accelerators connected in series to increase the working stroke; a hydraulic booster intensifying jarring force. The integrated unfreezing tool string based on these three elements can effectively overcome the friction caused by a deviated borehole, and thus unfreeze a stuck string with the interaction of the hydraulic booster and the mechanical jar which form an alternatively dynamic load. Experimental results show that the jarring performance parameters of the hydraulic booster-jar unfreezing tool string for the horizontal wells are in accordance with original design requirements. Then field technical parameters were developed based on numerical simulation and experimental data. Field application shows that the hydraulic booster-jar unfreezing tool string is effective to free stuck downhole tools in a horizontal well, and it reduces hook load by 80% and lessens the requirement of workover equipment. This provides a new technology to unfreeze stuck downhole string in a horizontal well.

Experimental determination of dosimetric characterization of a newly designed encapsulated interstitial brachytherapy source of 103Pd-model Pd-1

International Nuclear Information System (INIS)

Nath, Ravinder; Yue Ning; Roa, Eduardo

2002-01-01

A newly designed encapsulated 103 Pd source has been introduced (BrachySeed trade mark sign -Pd-103, also named Model Pd-1, manufactured by DRAXIMAGE Inc. and distributed by Cytogen Corp.) for interstitial brachytherapy to provide more isotropic dose distributions. In this work, the dosimetric characteristics of the 103 Pd source were measured with micro LiF TLD chips and dosimetry parameters were characterized based upon the American Association of Physicists in Medicine (AAPM) Task Group No. 43 formalism. The dose rate constant of the sources was determined to be 0.66±0.05 cGy h-1 U-1. The radial dose function was measured and was found to be similar to that of the Theragenics Model 200 103 Pd source. The anisotropy constant for the Model Pd-1 source was determined to be 1.03

Vertical-horizontal wells for depletion and sweep

Energy Technology Data Exchange (ETDEWEB)

Muraikhi, A. J.; Pham, T. R.; Liu, J. S.; Khatib, M. R.; Muhaish, A. S. [Saudi Aramco (Saudi Arabia)

1998-12-31

A well completion scheme currently in use in a thick, large, elongated carbonate anticline Middle-East oil reservoir is described. This method of well completion calls for a combination of an open hole horizontal section penetrating the top 10 feet of the reservoir and a cased or undisturbed vertical segment through the thick formation. The horizontal section is used for producing and the vertical segment is used for monitoring purposes. Field experience and supported reservoir simulation exercises have shown that the horizontal application is superior to conventional vertical completion both from the economic and from the sweep point of view. 4 refs., 12 figs.

Horizontal bridges in polar dielectric liquids

Energy Technology Data Exchange (ETDEWEB)

Woisetschlaeger, Jakob [Graz University of Technology, Experimental Turbomachinery Research and Optical Measurement Group, Institute for Thermal Turbomachinery and Machine Dynamics, Graz (Austria); Wexler, Adam D.; Fuchs, Elmar C. [Wetsus, Center of Excellence for Sustainable Water Technology, Leeuwarden (Netherlands); Holler, Gert [Graz University of Technology, Institute of Electrical Measurement and Measurement Signal Processing, Graz (Austria); Eisenhut, Mathias [Graz University of Technology, Institute of Analytical Chemistry and Food Chemistry, Graz (Austria); Gatterer, Karl [Graz University of Technology, Institute of Physical and Theoretical Chemistry, Graz (Austria)

2012-01-15

When a high-voltage direct-current is applied to two beakers filled with polar liquid dielectrica like water or methanol, a horizontal bridge forms between the two beakers. By repeating a version of Pellat's experiment, it is shown that a horizontal bridge is stable by the action of electrohydrodynamic pressure. Thus, the static and dynamic properties of the phenomenon called a 'floating water bridge' can be explained by the gradient of Maxwell pressure, replenishing the liquid within the bridge against any drainage mechanism. It is also shown that a number of liquids can form stable and long horizontal bridges. The stability of such a connection, and the asymmetry in mass flow through such bridges caused by the formation of ion clouds in the vicinity of the electrodes, is also discussed by two further experiments. (orig.)

Staged fracturing of horizontal shale gas wells with temporary plugging by sand filling

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Xing Liang

2017-03-01

Full Text Available Due to downhole complexities, shale-gas horizontal well fracturing in the Sichuan Basin suffered from casing deformation and failure to apply the technique of cable-conveyed perforation bridge plug. In view of these problems, a new technique of staged volume fracturing with temporary plugging by sand filling is employed. Based on theoretical analyses and field tests, a design of optimized parameters of coiled tubing-conveyed multi-cluster sand-blasting perforation and temporary plugging by sand filling was proposed. It was applied in the horizontal Well ZJ-1 in which casing deformation occurred. The following results are achieved in field operations. First, this technique enables selective staged fracturing in horizontal sections. Second, this technique can realize massive staged fracturing credibly without mechanical plugging, with the operating efficiency equivalent to the conventional bridge plug staged fracturing. Third, full-hole is preserved after fracturing, thus it is possible to directly conduct an open flow test without time consumption of a wiper trip. The staged volume fracturing with temporary plugging by sand filling facilitated the 14-stage fracturing in Well ZJ-1, with similar SRV to that achieved by conventional bridge plug staged fracturing and higher gas yield than neighboring wells on the same well pad. Thus, a new and effective technique is presented in multi-cluster staged volume fracturing of shale gas horizontal wells.

Bubble shape in horizontal and near horizontal intermittent flow

International Nuclear Information System (INIS)

Gu, Hanyang; Guo, Liejin

2015-01-01

Highlights: • The bubble shapes in intermittent flows are presented experimentally. • The nose-tail inversion phenomenon appears at a low Froude number in downward pipe. • Transition from plug to slug flow occurs when the bubble tail changes from staircase pattern to hydraulic jump. - Abstract: This paper presents an experimental study of the shape of isolated bubbles in horizontal and near horizontal intermittent flows. It is found that the shapes of the nose and body of bubble depend on the Froude number defined by gas/liquid mixture velocity in a pipe, whereas the shape of the back of bubble region depends on both the Froude number and bubble length. The photographic studies show that the transition from plug to slug flow occurs when the back of the bubble changes from staircase pattern to hydraulic jump with the increase of the Froude number and bubble length. The effect of pipe inclination on characteristics of bubble is significant: The bubble is inversely located in a downwardly inclined pipe when the Froude number is low, and the transition from plug flow to slug flow in an upward inclined pipe is more ready to occur compared with that in a downwardly inclined pipe

Widespread of horizontal gene transfer in the human genome.

Science.gov (United States)

Huang, Wenze; Tsai, Lillian; Li, Yulong; Hua, Nan; Sun, Chen; Wei, Chaochun

2017-04-04

A fundamental concept in biology is that heritable material is passed from parents to offspring, a process called vertical gene transfer. An alternative mechanism of gene acquisition is through horizontal gene transfer (HGT), which involves movement of genetic materials between different species. Horizontal gene transfer has been found prevalent in prokaryotes but very rare in eukaryote. In this paper, we investigate horizontal gene transfer in the human genome. From the pair-wise alignments between human genome and 53 vertebrate genomes, 1,467 human genome regions (2.6 M bases) from all chromosomes were found to be more conserved with non-mammals than with most mammals. These human genome regions involve 642 known genes, which are enriched with ion binding. Compared to known horizontal gene transfer regions in the human genome, there were few overlapping regions, which indicated horizontal gene transfer is more common than we expected in the human genome. Horizontal gene transfer impacts hundreds of human genes and this study provided insight into potential mechanisms of HGT in the human genome.

Optimal Design and Tuning of PID-Type Interval Type-2 Fuzzy Logic Controllers for Delta Parallel Robots

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Xingguo Lu

2016-05-01

Full Text Available In this work, we propose a new method for the optimal design and tuning of a Proportional-Integral-Derivative type (PID-type interval type-2 fuzzy logic controller (IT2 FLC for Delta parallel robot trajectory tracking control. The presented methodology starts with an optimal design problem of IT2 FLC. A group of IT2 FLCs are obtained by blurring the membership functions using a variable called blurring degree. By comparing the performance of the controllers, the optimal structure of IT2 FLC is obtained. Then, a multi-objective optimization problem is formulated to tune the scaling factors of the PID-type IT2 FLC. The Non-dominated Sorting Genetic Algorithm (NSGA-II is adopted to solve the constrained nonlinear multi-objective optimization problem. Simulation results of the optimized controller are presented and discussed regarding application in the Delta parallel robot. The proposed method provides an effective way to design and tune the PID-type IT2 FLC with a desired control performance.

Development and experiment of a 60 kW horizontal-axis marine current power system

International Nuclear Information System (INIS)

Xu, Quan-kun; Liu, Hong-wei; Lin, Yong-gang; Yin, Xiu-xing; Li, Wei; Gu, Ya-jing

2015-01-01

A 60 kW horizontal-axis marine current power system is designed, built and tested to provide potentially cost-competitive electrical power for residents in remote islands. This power system mainly consists of a three-bladed marine current turbine, a drive-train system, power electronics and a control console. The turbine blade parameters are reasonably calculated and optimized based on the blade element momentum theory. The hydrodynamic performances of this turbine are predicted over a wide range of operating conditions. An adequate drive-train system is carefully designed to make the marine power system work smoothly and quietly even under harsh marine current conditions. The control console is also developed to facilitate the condition monitoring and generator power and speed regulations for this power system by adequately controlling the onshore power electronics. This power system has been tested under real marine current conditions to thoroughly evaluate its dynamic characteristics and effectiveness. - Highlights: • A 60°kW horizontal-axis marine current power system is designed, built and tested. • Detailed design procedure and experimental data are provided. • Experimental results demonstrate high power convention efficiency of the system

Perfil epidemiológico da população idosa de Belo Horizonte, MG, Brasil Perfíl epidemológico de la población de ancianos de Belo Horizonte, MG, Brasil Epidemiological profile of the elderly population in Belo Horizonte, MG, Brazil

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Meire Chucre Tannure

2010-10-01

Belo Horizonte in 2000 represent 9.1% of total population residing therein. Population of elderly, 60.5% are women and 39.4% are men, 2.9% of the elderly had some type of physical disability, 16.4% have hearing loss, 23.5% find it hard to see, 24.1% have difficulty walking or climbing stairs, and that 3.8% had mental problems. It was concluded that the share of elderly people, weakened in Belo Horizonte was represented by less than one with good health. Aging is not synonymous with disability.

Prevalence of type 2 diabetes among newly detected pulmonary tuberculosis patients in China: a community based cohort study.

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Qiuzhen Wang

Full Text Available BACKGROUND: Patients with type 2 diabetes (DM have a higher risk of developing pulmonary tuberculosis (PTB; moreover, DM co-morbidity in PTB is associated with poor PTB treatment outcomes. Community based prevalence data on DM and prediabetes (pre-DM among TB patients is lacking, particularly from the developing world. Therefore we conducted a prospective study to investigate the prevalence of DM and pre-DM and evaluated the risk factors for the presence of DM among newly detected PTB patients in rural areas of China. METHODS AND FINDINGS: In a prospective community based study carried out from 2010 to 2012, a representative sample of 6382 newly detected PTB patients from 7 TB clinics in Linyi were tested for DM. A population of 6674 non-TB controls from the same community was similarly tested as well. The prevalence of DM in TB patients (6.3% was higher than that in non-TB controls (4.7%, p<0.05. PTB patients had a higher odds of DM than non-TB controls (adjusted OR 3.17, 95% CI 1.14-8.84. The prevalence of DM increased with age and was significantly higher in TB patients in the age categories above 30 years (p<0.05. Among TB patients, those with normal weight (BMI 18.5-23.9 had the lowest prevalence of DM (5.8%. Increasing age, family history of DM, positive sputum smear, cavity on chest X-ray and higher yearly income (≥10000 RMB yuan were positively associated and frequent outdoor activity was negatively associated with DM in PTB patients. CONCLUSIONS: The prevalence of DM in PTB patients was higher than in non-TB controls with a 3 fold higher adjusted odds ratio of having DM. Given the increasing DM prevalence and still high burden of TB in China, this association may represent a new public health challenge concerning the prevention and treatment of both diseases.

Design and optimization of membrane-type acoustic metamaterials

Science.gov (United States)

Blevins, Matthew Grant

One of the most common problems in noise control is the attenuation of low frequency noise. Typical solutions require barriers with high density and/or thickness. Membrane-type acoustic metamaterials are a novel type of engineered material capable of high low-frequency transmission loss despite their small thickness and light weight. These materials are ideally suited to applications with strict size and weight limitations such as aircraft, automobiles, and buildings. The transmission loss profile can be manipulated by changing the micro-level substructure, stacking multiple unit cells, or by creating multi-celled arrays. To date, analysis has focused primarily on experimental studies in plane-wave tubes and numerical modeling using finite element methods. These methods are inefficient when used for applications that require iterative changes to the structure of the material. To facilitate design and optimization of membrane-type acoustic metamaterials, computationally efficient dynamic models based on the impedance-mobility approach are proposed. Models of a single unit cell in a waveguide and in a baffle, a double layer of unit cells in a waveguide, and an array of unit cells in a baffle are studied. The accuracy of the models and the validity of assumptions used are verified using a finite element method. The remarkable computational efficiency of the impedance-mobility models compared to finite element methods enables implementation in design tools based on a graphical user interface and in optimization schemes. Genetic algorithms are used to optimize the unit cell design for a variety of noise reduction goals, including maximizing transmission loss for broadband, narrow-band, and tonal noise sources. The tools for design and optimization created in this work will enable rapid implementation of membrane-type acoustic metamaterials to solve real-world noise control problems.

The Rise of the Machines: Automation, Horizontal Innovation and Income Inequality

OpenAIRE

Morten Olsen; David Hemous

2014-01-01

We construct an endogenous growth model of directed technical change with automation (the introduction of machines which replace low-skill labor and complement high-skill labor) and horizontal innovation (the introduction of new products, which increases demand for both types of labor). For general processes of technical change, we demonstrate that although low-skill wages can drop during periods of increasing automation intensity, the asymptotic growth rate is weakly positive --- though lowe...

Réduction du nombre de puits par l'utilisation de forages horizontaux Reducing the Number of Wells by Using Horizontal Drilling

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Giger F.

2006-11-01

Full Text Available L'un des intérêts du forage horizontal est le gain de productivité sur chaque puits. L'objet de cet article est de proposer des éléments d'analyse, comme la productivité surfacique, destinés à aider l'instance responsable du développement d'un champ confrontée au choix économique entre un schéma classique par puits verticaux et un autre schéma intégrant des puits d'un autre type, et notamment des drains horizontaux. Des méthodes de résolution approchées d'emploi simple sont proposées pour évaluer le nombre de puits verticaux que peut remplacer un drain ho-rizontal. One of the advantages of horizontal drilling is the increase in productivity of each well. The aim of this article is to propose bases for making an analysis, such as areal productivity, so as to help the decision-maker responsible for the development of a field when confronted with an economic choice between a conventional system using vertical wells and an alternative system including other types of wells, and in particular horizontal wells. Simple and approximate solutions are proposed for evaluating the number of vertical wells that can be replaced by a horizontal wells.

Horizontal biases in rats’ use of three-dimensional space

Science.gov (United States)

Jovalekic, Aleksandar; Hayman, Robin; Becares, Natalia; Reid, Harry; Thomas, George; Wilson, Jonathan; Jeffery, Kate

2011-01-01

Rodent spatial cognition studies allow links to be made between neural and behavioural phenomena, and much is now known about the encoding and use of horizontal space. However, the real world is three dimensional, providing cognitive challenges that have yet to be explored. Motivated by neural findings suggesting weaker encoding of vertical than horizontal space, we examined whether rats show a similar behavioural anisotropy when distributing their time freely between vertical and horizontal movements. We found that in two- or three-dimensional environments with a vertical dimension, rats showed a prioritization of horizontal over vertical movements in both foraging and detour tasks. In the foraging tasks, the animals executed more horizontal than vertical movements and adopted a “layer strategy” in which food was collected from one horizontal level before moving to the next. In the detour tasks, rats preferred the routes that allowed them to execute the horizontal leg first. We suggest three possible reasons for this behavioural bias. First, as suggested by Grobety and Schenk [5], it allows minimisation of energy expenditure, inasmuch as costly vertical movements are minimised. Second, it may be a manifestation of the temporal discounting of effort, in which animals value delayed effort as less costly than immediate effort. Finally, it may be that at the neural level rats encode the vertical dimension less precisely, and thus prefer to bias their movements in the more accurately encoded horizontal dimension. We suggest that all three factors are related, and all play a part. PMID:21419172

Design, fabrication, and evaluation of a wireless pull-type dynamometer

Directory of Open Access Journals (Sweden)

I Ahmadi

2016-09-01

Full Text Available Introduction Measurement of the draft force exerted from agricultural machineries to the tractor and the calculation of the implement power requirements is important for agriculturalists in terms of machine design and tractor-machine matching . Therefore, studies about this issue have been started from the 1950’s. Zoerbet al.,(1983 claimed that the first dynamometers have been made of spring and in reality, users had difficulties reading these dynamometers gauge due to the quick variations of the gauge pointer. Therefore the second stage was the development of the hydraulic-type dynamometers in which the oil pressure inside the hydraulic cylinder-piston set installed between machine and tractor that can be readable with a bourdontube gauge was considered as its indicator. From the first years of the 1960’s development of the strain-gauge pull-type dynamometers started. In this study, design, fabrication and evaluation of a pull-type tractor dynamometer is considered that can be used to measure and store tractor forward velocity, and horizontal component of draft force exerted from wheel-type towed implements to the tractor. Therefore, drawbar power needed to pull the machine through the soil can be calculated. This dynamometer can also be utilized to measure three-point-hitch implement’s draft force and power requirements in condition that the RNAM (1983 method was used. In addition to measure the tractor velocity with a GPS receiver instead of a fifth wheel, the other particular issue about this dynamometer is that a remote controller is used to order data acquisition commands such as starting, ending, pausing and time zeroing in the process of data gathering. Materials and Methods In this study an S-type strain gauge load cell (model: SS300 and a GPS receiver (model: Micro GPS antenna AGM-10 + NEO-6-M-0-001 ublox AG board were utilized to measure the draft force and forward velocity, respectively. To calibrate the load cell sensor, in an

Parallel kinematics type, kinematics, and optimal design

CERN Document Server

Liu, Xin-Jun

2014-01-01

Parallel Kinematics- Type, Kinematics, and Optimal Design presents the results of 15 year's research on parallel mechanisms and parallel kinematics machines. This book covers the systematic classification of parallel mechanisms (PMs) as well as providing a large number of mechanical architectures of PMs available for use in practical applications. It focuses on the kinematic design of parallel robots. One successful application of parallel mechanisms in the field of machine tools, which is also called parallel kinematics machines, has been the emerging trend in advanced machine tools. The book describes not only the main aspects and important topics in parallel kinematics, but also references novel concepts and approaches, i.e. type synthesis based on evolution, performance evaluation and optimization based on screw theory, singularity model taking into account motion and force transmissibility, and others.   This book is intended for researchers, scientists, engineers and postgraduates or above with interes...

A New Method for Horizontal Axis Wind Turbine (HAWT Blade Optimization

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Mohammadreza Mohammadi

2016-02-01

Full Text Available Iran has a great potential for wind energy. This paper introduces optimization of 7 wind turbine blades for small and medium scales in a determined wind condition of Zabol site, Iran, where the average wind speed is considered 7 m /s. Considered wind turbines are 3 bladed and radius of 7 case study turbine blades are 4.5 m, 6.5 m, 8 m, 9 m, 10 m, 15.5 m and 20 m. As the first step, an initial design is performed using one airfoil (NACA 63-215 across the blade. In the next step, every blade is divided into three sections, while the 20 % of first part of the blade is considered as root, the 5% of last the part is considered as tip and the rest of the blade as mid part. Providing necessary input data, suitable airfoils for wind turbines including 43 airfoils are extracted and their experimental data are entered in optimization process. Three variables in this optimization problem would be airfoil type, attack angle and chord, where the objective function is maximum output torque. A MATLAB code was written for design and optimization of the blade, which was validated with a previous experimental work. In addition, a comparison was made to show the effect of optimization with two variables (airfoil type and attack angle versus optimization with three variables (airfoil type, attack angle and chord on output torque increase. Results of this research shows a dramatic increase in comparison to initial designed blade with one airfoil where two variable optimization causes 7.7% to 22.27 % enhancement and three variable optimization causes 17.91% up to 24.48% rise in output torque .Article History: Received Oct 15, 2015; Received in revised form January 2, 2016; Accepted January 14, 2016; Available online How to Cite This Article: Mohammadi, M., Mohammadi, A. and Farahat, S. (2016 A New Method for Horizontal Axis Wind Turbine (HAWT Blade Optimization. Int. Journal of Renewable Energy Development, 5(1,1-8. http://dx.doi.org/10.14710/ijred.5.1.1-8

Design configurations affecting flow pattern and solids accumulation in horizontal free water and subsurface flow constructed wetlands.

Science.gov (United States)

Pedescoll, A; Sidrach-Cardona, R; Sánchez, J C; Carretero, J; Garfi, M; Bécares, E

2013-03-01

The aim of this study was to evaluate the effect of different horizontal constructed wetland (CW) design parameters on solids distribution, loss of hydraulic conductivity over time and hydraulic behaviour, in order to assess clogging processes in wetlands. For this purpose, an experimental plant with eight CWs was built at mesocosm scale. Each CW presented a different design characteristic, and the most common CW configurations were all represented: free water surface flow (FWS) with different effluent pipe locations, FWS with floating macrophytes and subsurface flow (SSF), and the presence of plants and specific species (Typha angustifolia and Phragmites australis) was also considered. The loss of the hydraulic conductivity of gravel was greatly influenced by the presence of plants and organic load (representing a loss of 20% and c.a. 10% in planted wetlands and an overloaded system, respectively). Cattail seems to have a greater effect on the development of clogging since its below-ground biomass weighed twice as much as that of common reed. Hydraulic behaviour was greatly influenced by the presence of a gravel matrix and the outlet pipe position. In strict SSF CW, the water was forced to cross the gravel and tended to flow diagonally from the top inlet to the bottom outlet (where the inlet and outlet pipes were located). However, when FWS was considered, water preferentially flowed above the gravel, thus losing half the effective volume of the system. Only the presence of plants seemed to help the water flow partially within the gravel matrix. Copyright © 2012 Elsevier Ltd. All rights reserved.

Nondestructive assay of plutonium residue in horizontal storage tanks

International Nuclear Information System (INIS)

Marsh, S.F.

1985-01-01

Aqueous plutonium recovery and purification processes often involve the temporary storage of plutonium solutions in holding tanks. Because plutonium is known to precipitate from aqueous solutions under certain conditions, there is a continuing need to assay emptied tanks for plutonium residue. A portable gamma spectrometer system, specifically designed for this purpose, provides rapid assay of such plutonium residues in horizontal storage tanks. A means is thus available for the nondestructive analysis of these tanks on a regular schedule to ensure that significant deposits of plutonium are not allowed to accumulate. 5 figs

Characteristics of Buoyancy Driven Natural Ventilation through Horizontal Openings

DEFF Research Database (Denmark)

Li, Zhigang

through horizontal openings. Two cases of full-scale measurements of buoyancy driven natural ventilation through horizontal openings are performed: one horizontal opening and one horizontal opening combined with one vertical opening. For the case of one horizontal opening, the measurements are made....... Computational fluid dynamics (CFD) are used to study these two air flow cases. The air flow rate and air flow pattern are predicted and compared with the full-scale measurements. The measurement data are used to compare two CFD models: standard k- ε model and large eddy simulation (LES) model. The cases...... transient, unstable and complex, and the air flow rates oscillate with time. Correlations between the Froude number Fr and the opening ratio L/D are obtained, which is reasonable agreement with Epstein's formula derived from brine-water measurements, but the obtained Fr values show considerable deviations...

Translocation of radiocesium from stems and leaves of plants and the effect on radiocesium concentrations in newly emerged plant tissues

International Nuclear Information System (INIS)

Tagami, Keiko; Uchida, Shigeo; Ishii, Nobuyoshi; Kagiya, Shigeo

2012-01-01

An accident occurred at the Fukushima Dai-ichi Nuclear Power Plant in March 2011 at which time large amounts of radionuclides were released into the atmosphere and the sea. In early May 2011, it was found that newly emerged tea (Camellia sinensis) leaves contained radiocesium, both 134 Cs and 137 Cs in some areas more than 300 km away from the Fukushima plant. To understand the mechanisms of radiocesium transfer to newly emerged tissues (shoots, leaves and fruits) of other plants in the future, radiocesium concentrations in newly emerged leaves of 14 plant species collected from the sampling areas in and near National Institute of Radiological Sciences in Chiba, Japan. The studied plant types were: (1) herbaceous plants, (2) woody plants with no old leaves at the time of the March accident, and (3) woody plants with old leaves out before the accident. About 40–50 d after the start of the accident, newly emerged leaves from woody plant with old leaves tended to show higher values than other woody or herbaceous plants. Concentrations of radiocesium in newly emerged tissues of trees decreased with time, but they did not decrease to the level of herbaceous plants. The type of the plant and presence of old leaves at the time of the heavy deposition period affected the radiocesium concentrations in newly emerged tissues.

Intra-Wellbore Head Losses in a Horizontal Well with both Kinematic and Frictional Effects in an Anisotropic Confined Aquifer between Two Streams

Science.gov (United States)

Wang, Q.; Zhan, H.

2017-12-01

Horizontal drilling becomes an appealing technology for water exploration or aquifer remediation in recent decades, due to the decreasing operational cost and many technical advantages over the vertical wells. However, many previous studies on the flow into horizontal wells were based on the uniform flux boundary condition (UFBC) for treating horizontal wells, which could not reflect the physical processes of flow inside the well accurately. In this study, we investigated transient flow into a horizontal well in an anisotropic confined aquifer between two streams for three types of boundary conditions of treating the horizontal well, including UFBC, uniform head boundary condition (UHBC), and mixed-type boundary condition (MTBC). The MTBC model considered both kinematic and frictional effects inside the horizontal well, in which the kinematic effect referred to the accelerational and fluid inflow effects. The new solution of UFBC was derived by superimposing the point sink/source solutions along the axis of the horizontal well with a uniform strength. The solutions of UHBC and MTBC were obtained by a hybrid analytical-numerical method, and an iterative method was proposed to determine the minimum well segment number required to yield sufficiently accurate answer. The results showed that the differences among the UFBC, UHBC, MTBCFriction and MTBC solutions were obvious, in which MTBCFriction represented the solutions considering the frictional effect but ignoring the kinematic effect. The MTBCFriction and MTBC solutions were sensitive to the flow rate, and the difference of these two solutions increases with the flow rate, suggesting that the kinematic effect could not be ignored for studying flow to a horizontal well, especially when the flow rate is great. The well specific inflow (WSI) (which is the inflow per unit screen length at a specified location of the horizontal well) increased with the distance along the wellbore for the MTBC model at early stage, while

Mechanical and mathematical models of multi-stage horizontal fracturing strings and their application

Directory of Open Access Journals (Sweden)

Zhanghua Lian

2015-03-01

Full Text Available Multi-stage SRV fracturing in horizontal wells is a new technology developed at home and abroad in recent years to effectively develop shale gas or low-permeability reservoirs, but on the other hand makes the mechanical environment of fracturing strings more complicated at the same time. In view of this, based on the loading features of tubing strings during the multi-stage fracturing of a horizontal well, mechanical models were established for three working cases of multiple packer setting, open differential-pressure sliding sleeve, and open ball-injection sliding sleeve under a hold-down packer. Moreover, mathematical models were respectively built for the above three cases. According to the Lame formula and Von Mises stress calculation formula for the thick-walled cylinder in the theory of elastic mechanics, a mathematical model was also established to calculate the equivalent stress for tubing string safety evaluation when the fracturing string was under the combined action of inner pressure, external squeezing force and axial stress, and another mathematical model was built for the mechanical strength and safety evaluation of multi-stage fracturing strings. In addition, a practical software was developed for the mechanical safety evaluation of horizontal well multi-stage fracturing strings according to the mathematical model developed for the mechanical calculation of the multi-packer string in horizontal wells. The research results were applied and verified in a gas well of Tahe Oilfield in the Tarim Basin with excellent effects, providing a theoretical basis and a simple and reliable technical means for optimal design and safety evaluation of safe operational parameters of multi-stage fracturing strings in horizontal wells.

Horizontal and vertical seismic isolation of a nuclear power plant

International Nuclear Information System (INIS)

Ikonomou, A.S.

1983-01-01

This paper presents a study for the horizontal and vertical seismic isolation of a nuclear power plant with a base isolation system, developed by the author, called the Alexisismon. This system -- which comprises different schemes for horizontal or vertical or both horizontal and vertical isolation -- is a linear system based on the principle of separation of functions. That is, horizontal and vertical isolation are realized through different components and act independently from each other. As far as horizontal isolation is concerned, the role of transmitting vertical loads is uncoupled from the role of inducing horizontal restoring forces so that both functions can be performed without instability. It is possible either to provide both horizontal and vertical isolation to the whole nuclear plant or to isolate the whole plant horizontally and to provide vertical isolation to sensitive and costly equipment only. When the fundamental period of the plant or equipment is 2 seconds and when the vertical displacements are of the order of + or - 20 inches, the structure or equipment are protected against earthquakes up to 1.10 and 1.30 g for actual and 0.60 and 1.50 g for artificial accelerograms. In both cases all the isolation elements behave elastically up to these acceleration limits as well as the superstructure and equipment

A newly developed snack effective for enhancing bone volume

Directory of Open Access Journals (Sweden)

Hayashi Hidetaka

2009-07-01

Full Text Available Abstract Background The incidence of primary osteoporosis is higher in Japan than in USA and European countries. Recently, the importance of preventive medicine has been gradually recognized in the field of orthopaedic surgery with a concept that peak bone mass should be increased in childhood as much as possible for the prevention of osteoporosis. Under such background, we have developed a new bean snack with an aim to improve bone volume loss. In this study, we examined the effects of a newly developed snack on bone volume and density in osteoporosis model mice. Methods Orchiectomy (ORX and ovariectomy (OVX were performed for C57BL/6J mice of twelve-week-old (Jackson Laboratory, Bar Harbar, ME, USA were used in this experiment. We prepared and given three types of powder diet e.g.: normal calcium diet (NCD, Ca: 0.9%, Clea Japan Co., Tokyo, Japan, low calcium diet (LCD, Ca: 0.63%, Clea Japan Co., and special diet (SCD, Ca: 0.9%. Eighteen weeks after surgery, all the animals were sacrified and prepared for histomorphometric analysis to quantify bone density and bone mineral content. Results As a result of histomorphometric examination, SCD was revealed to enhance bone volume irrespective of age and sex. The bone density was increased significantly in osteoporosis model mice fed the newly developmental snack as compared with the control mice. The bone mineral content was also enhanced significantly. These phenomena were revealed in both sexes. Conclusion It is shown that the newly developed bean snack is highly effective for the improvement of bone volume loss irrespective of sex. We demonstrated that newly developmental snack supplements may be a useful preventive measure for Japanese whose bone mineral density values are less than the ideal condition.

High levels of immunoglobulin E and a continuous increase in immunoglobulin G and immunoglobulin M by age in children with newly diagnosed type 1 diabetes

DEFF Research Database (Denmark)

Svensson, Jannet; Eising, Stefanie; Mortensen, Henrik Bindesbøl

2012-01-01

The incidence of type 1 diabetes (T1D) is increasing, either because of environmental factors accelerating onset of the disease or because of inducement of autoimmune diabetes in children who previously were at lower risk. High levels of immunoglobulin (Ig), specifically, IgM and IgA, and a low...... level of IgG were reported in adult patients; however no studies have analyzed the increasing incidence in relation to Ig levels. Our aim was to describe Ig in children newly diagnosed with diabetes and in their healthy siblings. Children with T1D expressed significantly lower IgG (p

Low attendance at structured education for people with newly diagnosed type 2 diabetes: General practice characteristics and individual patient factors predict uptake.

Science.gov (United States)

Winkley, Kirsty; Stahl, Daniel; Chamley, Mark; Stopford, Rosanna; Boughdady, Monica; Thomas, Stephen; Amiel, Stephanie A; Forbes, Angus; Ismail, Khalida

2016-01-01

The aims were to determine the association between individual and neighbourhood factors and attendance at structured education amongst people with newly diagnosed type 2 diabetes (T2DM). Multi-level analysis of questionnaire data from a prospective cohort of adults newly diagnosed T2DM. Setting was primary care, London, UK. Main outcome was attendance at structured education within 2 years. Of 1790 people recruited, attendance data were available for 1626 (91%). Only 22.4% (n=365/1626) attended education. Attendance was independently associated with female gender (OR 1.28, 95% CI 1.05-1.46), lower HbA1c (OR 0.98 mmol/mol 95% CI 0.97-0.99) and non-smoker status (OR 1.36, 95% CI 1.07-1.55). General practice covariates, achievement of primary care targets for glycaemic control (OR 1.05, 95% C.I. 1.01-1.08) and recording of retinal screening (OR 0.96, 95% C.I. 0.93-0.99) were independently associated with attendance but unexplained general practice clustering accounted for 17% of the variance. Education uptake is low amongst people with new onset T2DM. Attenders are more likely to be female, non-smokers with better HbA1c. General practices achieving glycaemic targets are more likely to have patients who attend education. Strategies are needed to improve attendance at structured diabetes education particularly amongst hard to reach groups. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Intensity-modulated radiation therapy followed by GDP chemotherapy for newly diagnosed stage I/II extranodal natural killer/T cell lymphoma, nasal type.

Science.gov (United States)

Huang, Yu; Yang, Jianliang; Liu, Peng; Zhou, Shengyu; Gui, Lin; He, Xiaohui; Qin, Yan; Zhang, Changgong; Yang, Sheng; Xing, Puyuan; Sun, Yan; Shi, Yuankai

2017-09-01

Extranodal natural killer (NK)/T cell lymphoma, nasal type (ENKTL) is an aggressive non-Hodgkin lymphoma and the majority of ENKTL cases are diagnosed at the localized stage. Radiotherapy in combination with chemotherapy has been used for localized ENKTL, but the optimal combination treatment modality and the best first-line chemotherapy regimen have not been defined. In this retrospective study, 44 patients with newly diagnosed, stages I/II ENKTL were enrolled and received intensity-modulated radiation therapy (IMRT, 50-56 Gy) followed by GDP (gemcitabine, dexamethasone, and cisplatin) chemotherapy. The median number of chemotherapy cycles per patient was 4 (range, 2-6 cycles). At the end of treatment, the overall response rate was 95% (42/44), including 39 patients (89%) who attained complete response. Two patients developed systemic progression after IMRT. With a median follow-up of 37.5 months, the 3-year overall survival (OS) rate and progression-free survival (PFS) rate were 85% (95% CI, 74 to 96%) and 77% (95% CI, 64 to 91%), respectively. Locoregional and systemic failure rates for this treatment were 9% (4/44) and 14% (6/44), respectively. The most common grades 3 to 4 adverse events included leukopenia (37%), neutropenia (34%), and mucositis (25%). No treatment-related deaths were observed. This study suggested high efficacy and low toxicity of IMRT followed by GDP regimen chemotherapy for newly diagnosed stage I/II ENKTL patients. These results require further investigation in prospective trials.

Design method for strut-beam connection in hinged frames

OpenAIRE

Cardenal Basté, Joan

2011-01-01

Glulam is almost exclusively the chosen material of timber frame structures. Of those, three-hinged (three-pin) portal frames are incomparably the most common type. Being both statically determinate and stable against horizontal forces in its own plane o er both practical (basic constructive details) and economical bene ts. The design of the haunch allows for various solutions: it can be curved with continuous laminates, nger jointed, jointed with steel dowels and slotted-i...

Guidelines adherence in the treatment of patients with newly diagnosed type 2 diabetes: a historical cohort comparing the use of metformin in Quebec pre and post-Canadian Diabetes Association guidelines.

Science.gov (United States)

Wang, Ting-Yu; Eguale, Tewodros; Tamblyn, Robyn

2013-10-25

Given the high prevalence of diabetes, guidelines are updated frequently to reflect optimal treatment recommendations. Our study aims to measure the response of primary care physicians to changes in choice of initial therapy for patients with type 2 diabetes in relationship to a change in Canadian Diabetes Association (CDA) Guidelines in 2008. We also assessed patients' and physicians' factors which may affect this change. Historical cohort study of primary care physicians' participating in an electronic medical record research network in Quebec, Canada. 111 primary care physicians and 1279 newly treated patients with diabetes with a prescription of an oral hypoglycemic agent (OHA) between January 20 2003 and December 29 2011 were included. Multivariate GEE logistic regression was used to estimate the impact of guideline change on treatment choice controlling for patients' and physicians' characteristics. After the new CDA guidelines, there was an increase in incident use of metformin from 89.7% to 94.6% (OR 1.86, 95% CI 1.20-2.90) with an accompanying reduction in the use of thiazolidinediones (OR 0.21, 95% CI 0.08-0.55), and reduction in the initiation of sulfonylureas (OR 0.78, 95% CI 0.43-1.09). Physicians' attitudes to evidence-based practice did not significantly modify response to a change in guidelines recommendations. However, older patients and those with renal failure were less likely to receive metformin. Metformin initiation in newly diagnosed diabetes patients has increased post 2008 CDA guidelines. However, due to the nature of the study design, we can not determine whether the observed change in metformin prescribing was causally related to the change in the guideline.

Vertical vs. Horizontal Integration: Pre-emptive Merging.

OpenAIRE

Colangelo, Giuseppe

1995-01-01

Preemption plays a crucial role in arms merger decisions. The author studies whether and under which circumstances preemptive merging occurs in vertically related industries. He finds that vertical mergers often preempt horizontal mergers and are dominant outcomes. Preempting the threat of a detrimental horizontal integration may be the main reason for vertically integrating. Copyright 1995 by Blackwell Publishing Ltd.

Effect of weed control methods on some soil properties of a newly ...

African Journals Online (AJOL)

Weed control constitutes a high percentage of the total field maintenance cost of newly planted cocoa. Soil samples were collected from an experiment that was designed to evaluate some weed control methods during cocoa establishment. The objective of the experiment was to assess the effect of the weed control ...

Innovation pressure : service companies race to improve their horizontal multi-frac completion tools and techniques

Energy Technology Data Exchange (ETDEWEB)

Chandler, G.

2010-11-15

This article described innovations in horizontal multi-frac completion tools and techniques that service companies are providing in the field. BJ Services has developed coiled tubing technology for annular fracing in cased-hole horizontal wells, which enables producers to complete with closer spacing, and frac sleeves that form an integral part of the casing string. Trican Well Service Ltd. recommends pumping through casing to create an unobstructed conduit, reducing friction and allowing the high pressure needed to create complex fractures. The Burst Port System is designed for selective fracturing: integrated casing collars that contain pre-milled ports are placed into the horizontal well casing; the C2C, a selective fracturing cup tool with a unique pressure equalization valve, straddles the port; and pressure is built up the designated burst point, leaving an isolated conduit to the formation. Recent chemical innovations include ecologically safe frac fluids and fluids designed to work in cold temperatures. The Viking PW (produced water) system can accommodate produced water, recycled water, and recycled oil-based frac systems and tolerates other contaminants. Non-toxic EcoClean fluids protect water wells and aquifers during treatments. A new frac fluid modifies the surface property of proppant, allowing deeper penetration with less settling and banking. Advances in well simulation technology, micro-seismic techniques that can listen and locate fracing events in real time, and directional drillers were also described. Low gas prices are inspiring companies to improve efficiency ad lower costs, which is creating a greater emphasis on development. 2 figs.

Analytical, numerical and experimental investigations of transverse fracture propagation from horizontal wells

Energy Technology Data Exchange (ETDEWEB)

Rahman, M.M.; Hossain, M.M.; Crosby, D.G.; Rahman, M.K.; Rahman, S.S. [School of Petroleum Engineering, The University of New South Wales, 2052 Sydney (Australia)

2002-08-01

This paper presents results of a comprehensive study involving analytical, numerical and experimental investigations into transverse fracture propagation from horizontal wells. The propagation of transverse hydraulic fractures from horizontal wells is simulated and investigated in the laboratory using carefully designed experimental setups. Closed-form analytical theories for Mode I (opening) stress intensity factors for idealized fracture geometries are reviewed, and a boundary element-based model is used herein to investigate non-planar propagation of fractures. Using the mixed mode fracture propagation criterion of the model, a reasonable agreement is found with respect to fracture geometry, net fracture pressures and fracture propagation paths between the modeled fractures and the laboratory tested fractures. These results suggest that the propagation of multiple fractures requires higher net pressures than a single fracture, the underlying reason of which is theoretically justified on the basis of local stress distribution.

A Case Study of Horizontal Reuse in a Project-Driven Organisation

DEFF Research Database (Denmark)

Christensen, Henrik Bærbak; Røn, Henrik

2000-01-01

This experience paper presents observations, lessons learned, and recommendations based on a case study of reuse. The case study is concerned with the development, maturation, and reuse of a business domain independent software component (horizontal reuse) in a project-driven organisation that has...... knowledge is transferred within an organisation; (c) design patterns can be as risky as they can be beneficial; and (d) there is more to architectural mismatch than “merely ” packaging mismatch....

Assessment of Newly Proposed Clinical Criteria to Identify HNF1A MODY in Patients with an Initial Diagnosis of Type 1 or Type 2 Diabetes Mellitus

Directory of Open Access Journals (Sweden)

Malgorzata Grzanka

2016-01-01

Full Text Available The most common form of maturity-onset diabetes of the young (MODY is caused by mutations in the hepatocyte nuclear factor 1A (HNF1A gene. However, most HNF1A mutation-carriers are initially misdiagnosed with type 1 (T1DM or type 2 (T2DM diabetes mellitus; hence, they often receive nonoptimal treatment. The aim of our study was to test newly proposed clinical criteria for the identification of HNF1A MODY in patients with a diagnosis of T1DM or T2DM. To achieve this, the following criteria to preselect patients for screening were used: for T1DM: TDIR (total daily insulin requirement > 0.3 IU of insulin/kg and the percentage of basal insulin > 30% of TDIR; for T2DM: sulphonylurea- (SU- based oral treatment (monotherapy or combined with Metformin > 15 years and BMI < 30 kg/m2. We reviewed the clinical data of 140 patients with T1DM and 524 clinically diagnosed with T2DM. On the basis of these criteria, we found a HNF1A mutation in 1 out of 2 individuals with a diagnosis of T1DM and 1 out of 11 selected individuals with a diagnosis of T2DM. We believe that the simplicity of the proposed criteria might prove useful in clinical practice, as an alternative to more time-consuming classical diagnostic techniques.

Assessment of Newly Proposed Clinical Criteria to Identify HNF1A MODY in Patients with an Initial Diagnosis of Type 1 or Type 2 Diabetes Mellitus.

Science.gov (United States)

Grzanka, Malgorzata; Matejko, Bartlomiej; Szopa, Magdalena; Kiec-Wilk, Beata; Malecki, Maciej T; Klupa, Tomasz

2016-01-01

The most common form of maturity-onset diabetes of the young (MODY) is caused by mutations in the hepatocyte nuclear factor 1A (HNF1A) gene. However, most HNF1A mutation-carriers are initially misdiagnosed with type 1 (T1DM) or type 2 (T2DM) diabetes mellitus; hence, they often receive nonoptimal treatment. The aim of our study was to test newly proposed clinical criteria for the identification of HNF1A MODY in patients with a diagnosis of T1DM or T2DM. To achieve this, the following criteria to preselect patients for screening were used: for T1DM: TDIR (total daily insulin requirement) > 0.3 IU of insulin/kg and the percentage of basal insulin > 30% of TDIR; for T2DM: sulphonylurea- (SU-) based oral treatment (monotherapy or combined with Metformin) > 15 years and BMI < 30 kg/m(2). We reviewed the clinical data of 140 patients with T1DM and 524 clinically diagnosed with T2DM. On the basis of these criteria, we found a HNF1A mutation in 1 out of 2 individuals with a diagnosis of T1DM and 1 out of 11 selected individuals with a diagnosis of T2DM. We believe that the simplicity of the proposed criteria might prove useful in clinical practice, as an alternative to more time-consuming classical diagnostic techniques.

GABA sensitivity of spectrally classified horizontal cells in goldfish retina

NARCIS (Netherlands)

Verweij, J.; Kamermans, M.; Negishi, K.; Spekreijse, H.

1998-01-01

We studied the GABA sensitivity of horizontal cells in the isolated goldfish retina. After the glutamatergic input to the horizontal cells was blocked with DNQX, GABA depolarized the monophasic and biphasic horizontal cells. The pharmacology of these GABA-induced depolarizations was tested with the

New airfoils for small horizontal axis wind turbines

Energy Technology Data Exchange (ETDEWEB)

Giguere, P.; Selig, M.S. [Univ. of Illinois, Urbana, IL (United States)

1997-12-31

In a continuing effort to enhance the performance of small energy systems, one root airfoil and three primary airfoils were specifically designed for small horizontal axis wind turbines. These airfoils are intended primarily for 1-10 kW variable-speed wind turbines for both conventional (tapered/twisted) or pultruded blades. The four airfoils were wind-tunnel tested at Reynolds numbers between 100,000 and 500,000. Tests with simulated leading-edge roughness were also conducted. The results indicate that small variable-speed wind turbines should benefit from the use of the new airfoils which provide enhanced lift-to-drag ratio performance as compared with previously existing airfoils.

The design of high-speed windmills suitable for driving electric generators

Energy Technology Data Exchange (ETDEWEB)

Klein, G J

1975-01-01

A simple windmill theory is presented for designing a small, horizontal axis windmill for powering an automobile-type generator used along with a storage battery. Windmills designed by the method presented in this paper have maximum efficiencies in the order of 0.40 to 0.45, which approaches 75% of the theoretical maximum. Wind tunnel tests were performed on a two-bladed unit designed for a tip speed/wind speed ratio of 7. Maximum efficiency was close to 0.45 at a tip speed/wind speed ratio of slightly over 6. This windmill, if fitted directly to a specially wound three-brush automobile type generator, wil begin to charge a 6-volt battery at a wind speed of 7.5-8 mph. 2 refs., 7 figs., 1 tab.

Increased alanine aminotransferase levels and associated characteristics among newly diagnosed type 2 diabetes patients: Results from the DD2 study

DEFF Research Database (Denmark)

Mor, Anil; Thomsen, Reimar W.; Rungby, Jørgen

Objectives: Elevated levels of serum alanine aminotransferase (ALAT) have been linked with non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), insulin resistance and the metabolic syndrome in type 2 diabetes (T2D) patients. We examined ALAT levels in newly diagnosed T2D...... quartile (>32IU/L / >41IU/L for women/men). As compared to people with ALAT values in the lowest quartile, those with high ALAT were younger (median age 57 vs. 64 years, pobese (median BMI 31.2 vs. 29.1 kg/m2, p=0.004), and had a larger waist circumference (111 vs. 101 cm, p....0001) and higher median CRP levels (2.8 vs. 1.8 mg/L, p=0.0147). They also had substantially poorer glucose control (HbA1c 7.40 vs. 6.90%, p=0.084; fasting blood glucose 7.56 vs. 6.86 mmol/L, pvs. 4.15 mmol/L, p=0.006), whereas blood pressure was similar...

Management of Newly Diagnosed Atrial Fibrillation in an Outpatient Clinic Setting

DEFF Research Database (Denmark)

Thrysoee, Lars; Strömberg, Anna; Brandes, Axel

2018-01-01

fibrillation is not a fatal disease in itself was very important for patients. At the same time, visiting the clinic was overwhelming, information was difficult to understand, and patients found it difficult to be involved in decision-making. CONCLUSIONS: This study indicates that patients were uncertain......AIMS: To gain in-depth knowledge of patients' experiences of the consultation processes at a multidisciplinary atrial fibrillation outpatient clinic in a university hospital in Denmark. BACKGROUND: Atrial fibrillation is the most common cardiac arrhythmia associated with morbidity and mortality...... if not diagnosed and treated as recommended. Patients with newly diagnosed atrial fibrillation preferably should be managed in an outpatient setting which includes medical examination, patient education and decision making on medical therapy. DESIGN: This is a qualitative study of 14 patients newly diagnosed...

Cross-Linking Mast Cell Specific Gangliosides Stimulates the Release of Newly Formed Lipid Mediators and Newly Synthesized Cytokines

Directory of Open Access Journals (Sweden)

Edismauro Garcia Freitas Filho

2016-01-01

Full Text Available Mast cells are immunoregulatory cells that participate in inflammatory processes. Cross-linking mast cell specific GD1b derived gangliosides by mAbAA4 results in partial activation of mast cells without the release of preformed mediators. The present study examines the release of newly formed and newly synthesized mediators following ganglioside cross-linking. Cross-linking the gangliosides with mAbAA4 released the newly formed lipid mediators, prostaglandins D2 and E2, without release of leukotrienes B4 and C4. The effect of cross-linking these gangliosides on the activation of enzymes in the arachidonate cascade was then investigated. Ganglioside cross-linking resulted in phosphorylation of cytosolic phospholipase A2 and increased expression of cyclooxygenase-2. Translocation of 5-lipoxygenase from the cytosol to the nucleus was not induced by ganglioside cross-linking. Cross-linking of GD1b derived gangliosides also resulted in the release of the newly synthesized mediators, interleukin-4, interleukin-6, and TNF-α. The effect of cross-linking the gangliosides on the MAP kinase pathway was then investigated. Cross-linking the gangliosides induced the phosphorylation of ERK1/2, JNK1/2, and p38 as well as activating both NFκB and NFAT in a Syk-dependent manner. Therefore, cross-linking the mast cell specific GD1b derived gangliosides results in the activation of signaling pathways that culminate with the release of newly formed and newly synthesized mediators.

Students' perceptions of vertical and horizontal integration in a discipline-based dental school.

Science.gov (United States)

Postma, T C; White, J G

2017-05-01

Integration is a key concern in discipline-based undergraduate dental curricula. Therefore, this study compared feedback on integration from students who participated in different instructional designs in a Comprehensive Patient Care course. The study was conducted at the University of Pretoria (2009-2011). Third-year cohorts (Cohorts A, B and C) participated in pre-clinical case-based learning, whilst fourth-year cohorts (Cohorts D and E) received didactic teaching in Comprehensive Patient Care. Cohorts A, D and E practised clinical Comprehensive Patient Care in a discipline-based clinic. Cohort B conducted their Comprehensive Patient Care patient examinations in a dedicated facility supervised by dedicated faculty responsible to teach integration. Students had to indicate on visual analogue scales whether the way they were taught at the school helped them to integrate knowledge from the same (horizontal integration) and preceding (vertical integration) year of study. The end-points of the scales were defined as 'definitely' and 'not at all'. Analysis of variance (ANOVA) was employed to measure the differences between cohorts according to the year of study. Third-year case-based learning cohorts rated the horizontal integration close to 80/100 and vertical integration ranging from 64 to 71/100. In year four, Cohort B rated vertical and horizontal integration 9-15% higher (ANOVA, P horizontal integration 11-18% higher (ANOVA, P integration in the discipline-based undergraduate dental curriculum. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Critical thinking dispositions among newly graduated nurses

Science.gov (United States)

Wangensteen, Sigrid; Johansson, Inger S; Björkström, Monica E; Nordström, Gun

2010-01-01

wangensteen s., johansson i.s., björkström m.e. & nordström g. (2010) Critical thinking dispositions among newly graduated nurses. Journal of Advanced Nursing66(10), 2170–2181. Aim The aim of the study was to describe critical thinking dispositions among newly graduated nurses in Norway, and to study whether background data had any impact on critical thinking dispositions. Background Competence in critical thinking is one of the expectations of nursing education. Critical thinkers are described as well-informed, inquisitive, open-minded and orderly in complex matters. Critical thinking competence has thus been designated as an outcome for judging the quality of nursing education programmes and for the development of clinical judgement. The ability to think critically is also described as reducing the research–practice gap and fostering evidence-based nursing. Methods A cross-sectional descriptive study was performed. The data were collected between October 2006 and April 2007 using the California Critical Thinking Disposition Inventory. The response rate was 33% (n= 618). Pearson’s chi-square tests were used to analyse the data. Results Nearly 80% of the respondents reported a positive disposition towards critical thinking. The highest mean score was on the Inquisitiveness subscale and the lowest on the Truth-seeking subscale. A statistically significant higher proportion of nurses with high critical thinking scores were found among those older than 30 years, those with university education prior to nursing education, and those working in community health care. Conclusion Nurse leaders and nurse teachers should encourage and nurture critical thinking among newly graduated nurses and nursing students. The low Truth-seeking scores found may be a result of traditional teaching strategies in nursing education and might indicate a need for more student-active learning models. PMID:20384637

Horizontal transfer of miR-106a/b from cisplatin resistant hepatocarcinoma cells can alter the sensitivity of cervical cancer cells to cisplatin.

Science.gov (United States)

Raji, Grace R; Sruthi, T V; Edatt, Lincy; Haritha, K; Sharath Shankar, S; Sameer Kumar, V B

2017-10-01

Recent studies indicate that horizontal transfer of genetic material can act as a communication tool between heterogenous populations of tumour cells, thus altering the chemosensitivity of tumour cells. The present study was designed to check whether the horizontal transfer of miRNAs released by cisplatin resistant (Cp-r) Hepatocarcinoma cells can alter the sensitivity of cervical cancer cells. For this exosomes secreted by cisplatin resistant and cisplatin sensitive HepG2 cells (EXres and EXsen) were isolated and characterised. Cytotoxicity analysis showed that EXres can make Hela cells resistant to cisplatin. Analysis of miR-106a/b levels in EXres and EXsen showed that their levels vary. Mechanistic studies showed that miR-106a/b play an important role in EXsen and EXres mediated change in chemosensitivity of Hela cells to cisplatin. Further SIRT1 was identified as a major target of miR-106a/b using in silico tools and this was proved by experimentation. Also the effect of miR-106a/b in chemosensitivity was seen to be dependent on regulation of SIRT1 by miR-106a/b. In brief, this study brings into light, the SIRT1 dependent mechanism of miR-106a/b mediated regulation of chemosensitivity upon the horizontal transfer from one cell type to another. Copyright © 2017 Elsevier Inc. All rights reserved.

Newly Homeless Youth Typically Return Home

OpenAIRE

Milburn, Norweeta G.; Rosenthal, Doreen; Rotheram-Borus, Mary Jane; Mallett, Shelley; Batterham, Philip; Rice, Eric; Solorio, Rosa

2007-01-01

165 newly homeless adolescents from Melbourne, Australia and 261 from Los Angeles, United States were surveyed and followed for two years. Most newly homeless adolescents returned home (70% U.S., 47% Australia) for significant amounts of time (39% U.S., 17% Australia more than 12 months) within two years of becoming homeless.

Numerical investigation of supercritical water-cooled nuclear reactor in horizontal rod bundles

Energy Technology Data Exchange (ETDEWEB)

Shang Zhi, E-mail: shangzhi@tsinghua.org.c [Faculty of Engineering, Kingston University, London SW15 3DW (United Kingdom); Science and Technology Facilities Council, Daresbury Laboratory, Warrington WA4 4AD (United Kingdom); Lo, Simon, E-mail: simon.lo@uk.cd-adapco.co [CD-adapco, Trident House, Basil Hill Road, Didcot OX11 7HJ (United Kingdom)

2010-04-15

The commercial CFD code STAR-CD v4.02 is used as a numerical simulation tool for flows in the supercritical water-cooled nuclear reactor (SCWR). The basic heat transfer element in the reactor core can be considered as round rods and rod bundles. Reactors with vertical or horizontal flow in the core can be found. In vertically oriented core, symmetric characters of flow and heat transfer can be found and two-dimensional analyses are often performed. However, in horizontally oriented core the flow and heat transfer are fully three-dimensional due to the buoyancy effect. In this paper, horizontal rods and rod bundles at SCWR conditions are studied. Special STAR-CD subroutines were developed by the authors to correctly represent the dramatic change in physical properties of the supercritical water with temperature. In the rod bundle simulations, it is found that the geometry and orientation of the rod bundle have strong effects on the wall temperature distributions and heat transfers. In one orientation the square bundle has a higher wall temperature difference than other bundles. However, when the bundles are rotated by 90 deg. the highest wall temperature difference is found in the hexagon bundle. Similar analysis could be useful in design and safety studies to obtain optimum fuel rod arrangement in a SCWR.

Horizontal beam tubes in FRM-II

International Nuclear Information System (INIS)

Coors, D.; Vanvor, D.

2001-01-01

The new research reactor in Garching FRM-II is equipped with 10 leak tight horizontal beam tubes (BT1 - BT10), each of them consisting of a beam tube structure taking an insert with neutron channels. The design of all beam tube structures is similar whereas the inserts are adapted to the special requirements of the using of each beam tube. Inside the reflector tank the beam tube structures are shaped by the inner cones which are made of Al-alloy with circular and rectangular cross sections. They are located in the region of maximum neutron flux (exception BT10), they are directly connected to the flanges of the reflector tank, their lengths are about 1.5 m (exception BT10) and their axes are directed tagentially to the core centre thus contributing to a low γ-noise at the experiments. (orig.)

Measurements of Convective Heat Transfer from a Horizontal Cylinder Rotating in a Pool of Water

International Nuclear Information System (INIS)

Becker, Kurt M.

1963-05-01

The present paper deals with measurements of heat transfer from a horizontal cylinder rotating in water. The experimental results have been correlated by the equation Nu = 0.11.Re 0.68 .Pr 0.4 for a range of rotating Reynolds numbers from 1000 to 46000, and Prandtl numbers from 2.2 to 6.4, This equation compares very well with the experimental and theoretical information available for air in published works. The analogy suggested by Anderson and Saunders between natural convection from a horizontal plate and the present type of flow has been used to predict the Nusselt numbers. Analytical and experimental results have been found to compare very well with each other

Measurements of Convective Heat Transfer from a Horizontal Cylinder Rotating in a Pool of Water

Energy Technology Data Exchange (ETDEWEB)

Becker, Kurt M

1963-05-15

The present paper deals with measurements of heat transfer from a horizontal cylinder rotating in water. The experimental results have been correlated by the equation Nu = 0.11.Re{sup 0.68}.Pr{sup 0.4} for a range of rotating Reynolds numbers from 1000 to 46000, and Prandtl numbers from 2.2 to 6.4, This equation compares very well with the experimental and theoretical information available for air in published works. The analogy suggested by Anderson and Saunders between natural convection from a horizontal plate and the present type of flow has been used to predict the Nusselt numbers. Analytical and experimental results have been found to compare very well with each other.

Design patterns for digital item types in higher education

NARCIS (Netherlands)

Draaijer, S.; Hartog, R.J.M.

2007-01-01

A set of design patterns for digital item types has been developed in response to challenges identified in various projects by teachers in higher education. The goal of the projects in question was to design and develop formative and summative tests, and to develop interactive learning material in

Hope, emotion regulation, and psychosocial well-being in patients newly diagnosed with cancer.

Science.gov (United States)

Peh, Chao Xu; Kua, Ee Heok; Mahendran, Rathi

2016-05-01

Patients newly diagnosed with cancer are often confronted with feelings of uncertainty and life threat. A significant proportion may report impairments in psychosocial well-being. Previous studies examining protective psychological factors such as hope and emotion regulation (ER) have yet to investigate these processes concurrently within a common self-regulation framework and/or focus on newly diagnosed patients. The present study aimed to examine how hope and ER may relate to psychosocial outcomes of patients newly diagnosed with cancer. The present study used a cross-sectional design with self-report questionnaires. Participants were newly diagnosed patients (N = 101) recruited from three cancer therapy clinics in a hospital. Patients completed measures of hope, ER (cognitive reappraisal and expressive suppression), and psychosocial well-being (life satisfaction and negative affectivity). Findings showed that (1) hope and reappraisal, but not suppression, were associated with well-being and (2) the interaction between hope and reappraisal was associated with well-being; reappraisal was not associated with well-being in high hope patients, while high reappraisal was associated with better well-being in low hope patients. Individual differences in hope and reappraisal appeared to be associated with psychosocial outcomes in newly diagnosed cancer patients. Hopeful thinking appeared to benefit patients' psychosocial well-being. In addition, an interaction effect between hope and reappraisal suggested that reappraisal as an ER strategy may be particularly adaptive for patients with low hope.

Evaluation of SKB/Posiva's report on the horizontal alternative of the KBS-3 method

International Nuclear Information System (INIS)

Apted, Michael J.; Bennet, David G.; Saario, Timtetr; Savage, David

2009-10-01

The KBS-3 method, based on multiple barriers, is the proposed spent fuel disposal method both in Sweden and Finland. The method has two design alternatives: the vertical (KBS-3V) and the horizontal (KBS-3H). In the KBS-3H concept, copper canisters loaded with spen nuclear fuel are encased in a compacted bentonite buffer with an outer supporting supercontainer composed of a mild steel basket, and the entire supercontainer is emplaced horizontally in long emplacement drifts. SKB and Posiva have conducted a joint research, development and demonstration (RDandD) programme in 2002-2007 with the overall aim of establishing whether the KBS-3H represents a feasible alternative to the reference alternative KBS-3V. The objectives have been to demonstrate that the horizontal deposition alternative is technically feasible and that it fulfils the same long-term safety requirement as the KBS-3V. Swedish Radiation Safety Authority (SSM) considers that it is a proper time to evaluate the work carried by SKB and Posiva when this period of joint research is ended and a relatively complete set of reporting is available. SSM therefore required its external expert group BRITE (the Barrier Review, Integration, Tracking and Evaluation) to evaluate the reporting. The aims of the evaluation are to investigate the differences between the horizontal and vertical design alternatives with respect to: Completeness: has SKB/Posiva identified the full set of key topics, and if not, what additional specific key topics should be evaluated; Depth-of-treatment: has SKB/Posiva analysed the key topics in sufficient depth, and if not, on what specific aspects in more detailed consideration required; Status of information: has SKB/ Posiva provided enough information on the current status of knowledge and uncertainties that impact the understanding of each key topic, and if not, what further information should be cited; Feasibility and practicality: for key issues related to the fabrication and

Circulating Levels of MicroRNA from Children with Newly Diagnosed Type 1 Diabetes and Healthy Controls: Evidence That miR-25 Associates to Residual Beta-Cell Function and Glycaemic Control during Disease Progression

DEFF Research Database (Denmark)

Nielsen, Lotte B.; Wang, Cheng; Sorensen, Kaspar

2012-01-01

This study aims to identify key miRNAs in circulation, which predict ongoing beta-cell destruction and regeneration in children with newly diagnosed Type 1 Diabetes (T1D). We compared expression level of sera miRNAs from new onset T1D children and age-matched healthy controls and related the miRN...

In situ bioremediation via horizontal wells

International Nuclear Information System (INIS)

Hazen, T.C.; Looney, B.B.; Enzien, M.; Dougherty, J.M.; Wear, J.; Fliermans, C.B.; Eddy, C.A.

1993-01-01

The test consisted of methane mixed with air into the contaminated aquifer via a horizontal well and extraction from the vadose zone via a parallel horizontal well. This configuration has the advantage of simultaneously stimulating methanotrophic activity in both the groundwater and vadose zone, and inhibiting spread of the contaminant plume. Groundwater was monitored biweekly from 13 wells for a variety of chemical and microbiological parameters. Groundwater from wells in affected areas showed increases in methanotrophs of more than 1 order of magnitude every 2 weeks for several weeks after 1% methane-in-air injection was started. Some wells had increases as much as 7 orders of magnitude. Simultaneous with the increase in methanotrophs was a decrease in water and soil gas concentrations of trichloroethylene (TCE) and tetrachloroethane (PCE). Two wells declined in TCE/PCE concentration in the water by more than 90% to below 2 ppb. All of the wells in the affected zone showed significant decreases in contaminants in less than one month. Chloride concentrations in the water were inversely correlated with TCE/PCE concentration. Four of five vadose zone piezometers declined from concentration as high as 10,000 ppm to less than 5 ppm in less than 6 weeks. The fifth cluster also declined by more than 95%. After only three months on injection, a decline in TCE/PCE in the sediment of more than 30% was also observed, with TCE/PCE being undetectable in most sediments at the end of the 14-month test. Gene probes and direct isolation from the water and sediment revealed that the right types of methanotrophs were being stimulated and that isolates could degrade TCE at a high rate

Guided self-determination improves life skills with Type 1 diabetes and A1C in randomized controlled trial

DEFF Research Database (Denmark)

Zoffmann, Vibeke; Lauritzen, Torsten

2006-01-01

Objective To report 1-year results of newly developed method, guided self-determination (GSD), applied in group training (GSD-GT) for Type 1 diabetes patients with persistent poor glycaemic control. Methods GSD was designed on the basis of qualitative research to help patients develop life skills...... is a worthy candidate for further research. We consider it adjustable to people with type 2 diabetes and other chronic conditions....

Widespread of horizontal gene transfer in the human genome

OpenAIRE

Huang, Wenze; Tsai, Lillian; Li, Yulong; Hua, Nan; Sun, Chen; Wei, Chaochun

2017-01-01

Background A fundamental concept in biology is that heritable material is passed from parents to offspring, a process called vertical gene transfer. An alternative mechanism of gene acquisition is through horizontal gene transfer (HGT), which involves movement of genetic materials between different species. Horizontal gene transfer has been found prevalent in prokaryotes but very rare in eukaryote. In this paper, we investigate horizontal gene transfer in the human genome. Results From the pa...

Age vs. experience : evaluation of a video feedback intervention for newly licensed teen drivers.

Science.gov (United States)

2013-02-06

This project examines the effects of age, experience, and video-based feedback on the rate and type of safety-relevant events captured on video event : recorders in the vehicles of three groups of newly licensed young drivers: : 1. 14.5- to 15.5-year...

Perceived Stress and Coping Strategies among Newly Nurse Students in Clinical Practice

Science.gov (United States)

Mahfouz, Rasha; Alsahli, Haya

2016-01-01

The present study aimed at assessing the stress level and coping strategies among students who were newly in Practicing the clinical training in different hospitals, at the Nursing College, Princess Nourah University. The study design was a descriptive analytical one. The study was conducted at the beginning of second semester in the academic year…

Problems in the wellbore integrity of a shale gas horizontal well and corresponding countermeasures

Directory of Open Access Journals (Sweden)

Zhonglan Tian

2015-12-01

Full Text Available In the Changning–Weiyuan national shale gas demonstration area, SW Sichuan Basin, the wellbore integrity damage occurs in some shale gas wells and has direct effect on the gas production rate of single shale gas horizontal well. After statistics analysis was performed on the problems related with wellbore integrity, such as casing damage, casing running difficulty and cement sheath blow-by, the multi-factor coupling casing stress calculation and evaluation mode laws established. Then study was conducted on the influential mechanism of multi-factor coupling (temperature effect, casing bending and axial pressure on casing damage. The shale slip mechanism and its relationship with casing sheared formation were analyzed by using the Mohr–Coulomb criterion. Inversion analysis was performed on the main controlling factors of casing friction by using the developed casing hook load prediction and friction analysis software. And finally, based on the characteristics of shale gas horizontal wells, wellbore integrity control measures were proposed in terms of design and construction process, so as to improve the drilling quality (DQ. More specifically, shale gas well casing design calculation method and check standard were modified, well structure and full bore hole trajectory design were optimized, drilling quality was improved, cement properties were optimized and cement sealing integrity during fracturing process was checked. These research findings are significant in the design and management of future shale gas borehole integrity.

Sidewall containment of liquid metal with horizontal alternating magnetic fields

Science.gov (United States)

Pareg, Walter F.

1990-01-01

An apparatus for confining molten metal with a horizontal alternating magnetic field. In particular, this invention employs a magnet that can produce a horizontal alternating magnetic field to confine a molten metal at the edges of parallel horizontal rollers as a solid metal sheet is cast by counter-rotation of the rollers.

Influence of facing vertical stiffness on reinforced soil wall design

OpenAIRE

Puig Damians, Ivan; Bathurst, Richard; Josa Garcia-Tornel, Alejandro; Lloret Morancho, Antonio

2013-01-01

Current design practices for reinforced soil walls typically ignore the influence of facing type and foundation compressibility on the magnitude and distribution of reinforcement loads in steel reinforced soil walls under operational conditions. In this paper, the effect of the facing vertical stiffness (due to elastomeric bearing pads placed in the horizontal joints between panels) on load capacity of steel reinforced soil walls is examined in a systematic manner using a numerical modelli...

A horizontal well analysis from a view of its productivity

Directory of Open Access Journals (Sweden)

Lucia Sciranková

2006-10-01

Full Text Available The 1990s may become known in the oil field as the decade of the horizontal well. Horizontal wells can increase the production rate and the ultimate recovery, and can reduce the number of platforms on wells required to develop a reservoir.An empirical equation to calculate the inflow performance of two-phase flow for a vertical and a horizontal well in regime of dissolved gas presented by Vogel in 1968. His equation was based on the results of reservoir simulation. The created model whore result (output is the ratio of the productivity of a horizontal well to the productivity of a vertical well for a given area expressed by anumber of vertical wells the replaced by one horizontal well. The model is applied for a concrete ideological model.

A horizontal dilution refrigerator for polarized target

International Nuclear Information System (INIS)

Isagawa, S.; Ishimoto, S.; Masaike, A.; Morimoto, K.

1978-01-01

A horizontal dilution refrigerator was constructed with a view to the spin frozen target and the deuteron polarized target. High cooling power at high temperature such as 3.7 mW at 400 mK serves for overcoming a heat load of microwave to polarize the nuclear spins in the target material. The cooling power at 50 mK was 50 μW, which is sufficient to hold the high nuclear polarization for long time. The lowest temperature reached was 26 mK. The refrigerator has rather simple heat exchangers, a long stainless steel double tube heat exchanger and two coaxial type heat exchangers with sintered copper. The mixing chamber is made of polytetrafluoroethylene (TFE) and demountable so that the target material can be easily put into it. (Auth.)

Optimization model for rotor blades of horizontal axis wind turbines

Institute of Scientific and Technical Information of China (English)

LIU Xiong; CHEN Yan; YE Zhiquan

2007-01-01

This paper presents an optimization model for rotor blades of horizontal axis wind turbines. The model refers to the wind speed distribution function on the specific wind site, with an objective to satisfy the maximum annual energy output. To speed up the search process and guarantee a global optimal result, the extended compact genetic algorithm (ECGA) is used to carry out the search process.Compared with the simple genetic algorithm, ECGA runs much faster and can get more accurate results with a much smaller population size and fewer function evaluations. Using the developed optimization program, blades of a 1.3 MW stall-regulated wind turbine are designed. Compared with the existing blades, the designed blades have obviously better aerodynamic performance.

Ethical climate and nurse competence - newly graduated nurses' perceptions.

Science.gov (United States)

Numminen, Olivia; Leino-Kilpi, Helena; Isoaho, Hannu; Meretoja, Riitta

2015-12-01

Nursing practice takes place in a social framework, in which environmental elements and interpersonal relations interact. Ethical climate of the work unit is an important element affecting nurses' professional and ethical practice. Nevertheless, whatever the environmental circumstances, nurses are expected to be professionally competent providing high-quality care ethically and clinically. This study examined newly graduated nurses' perception of the ethical climate of their work environment and its association with their self-assessed professional competence, turnover intentions and job satisfaction. Descriptive, cross-sectional, correlational research design was applied. Participants consisted of 318 newly graduated nurses. Data were collected electronically and analysed statistically. Ethical approval and permissions to use instruments and conduct the study were obtained according to required procedures. Data were rendered anonymous to protect participant confidentiality. Completing the questionnaire was interpreted as consent to participate. Nurses' overall perception of the ethical climate was positive. More positive perceptions related to peers, patients and physicians, and less positive to hospitals and managers. Strong associations were found between perceived ethical climate and self-assessed competence, turnover intentions in terms of changing job, and job satisfaction in terms of quality of care. Nurses at a higher competence level with positive views of job satisfaction and low turnover intentions perceived the climate significantly more positively. Nursing management responsible for and having the power to implement changes should understand their contribution in ethical leadership, as well as the multidimensional nature of nurses' work environment and the interaction between work-related factors in planning developmental measures. Future research should focus on issues in nurse managers' ethical leadership in creating ethical work environments. There

Increased plasma dipeptidyl peptidase-4 activities are associated with high prevalence of subclinical atherosclerosis in Chinese patients with newly diagnosed type 2 diabetes: a cross-sectional study.

Science.gov (United States)

Zheng, T P; Liu, Y H; Yang, L X; Qin, S H; Liu, H B

2015-10-01

Hyperglycemia, insulin resistance, dislipidemia, oxidative stress and inflammation are well-documented risk factors for subclinical atherosclerosis. Dipeptidyl peptidase-4(DPP4) is a newly identified adipokine related to these risk factors. Hence, we aimed to investigate the association between plasma DPP4 activities and subclinical atherosclerosis in type 2 diabetes. A total of 985 newly diagnosed type 2 diabetic subjects were studied. Plasma DPP4 activity, mannose 6-phosphate receptor (M6P-R), oxidative stress parameters, inflammatory markers and common carotid artery Intima-Media Thickness (c-IMT) were measured in all participants. Participants in the highest quartile of DPP4 activity had higher HbA1c, homeostatic model assessment of insulin resistance(HOMA-IR), triglyceride, low-density lipoprotein cholesterol(LDL-C), oxidized LDL, nitrotyrosine, 8-iso-PGF2a, interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), M6P-R, c-IMT compared with participants in the lowest quartile (all P dislipidemia, oxidative stress and inflammation were higher with increasing DPP4 quartiles (P < 0.001 for trend). In the highest DPP4 quartile, subclinical atherosclerosis risk was significantly higher (OR 4.97; 95% CI 3.03-8.17) than in the lowest quartile. This association remained strong (2.17; 1.21-3.89) after further controlling for HbA1c, HOMA-IR, triglyceride, oxidized LDL, nitrotyrosine, and IL-6. This study shows that increased DPP4 activities are positively and independently associated with subclinical atherosclerosis in type 2 diabetes. Our findings suggest of potential role of DPP4 in the pathogenesis of subclinical atherosclerosis and in the prevention and management of this disease. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

PARTITION EFFICIENCY OF NEWLY DESIGNED LOCULAR MULTILAYER COIL FOR COUNTERCURRENT CHROMATOGRAPHIC SEPARATION OF PROTEINS USING SMALL-SCALE CROSS-AXIS COIL PLANET CENTRIFUGE WITH AQUEOUS-AQUEOUS POLYMER PHASE SYSTEMS.

Science.gov (United States)

Shinomiya, Kazufusa; Ito, Yoichiro

2009-01-01

Countercurrent chromatographic performance of the locular multilayer coil separation column newly designed in our laboratory was evaluated in terms of theoretical plate number, peak resolution and retention of the stationary phase in protein separation with an aqueous polymer phase system using the small-scale cross-axis coil planet centrifuge (X-axis CPC) fabricated in our laboratory. The locular column was made from 1.0 mm I.D., 2.0 mm O.D. or 1.5 mm I.D., 2.5 mm O.D. PTFE tubing compressed with a pair of hemostat at 2 or 4 cm intervals. The protein separation was performed using a set of stable proteins including cytochrome C, myoglobin and lysozyme with the 12.5% (w/w) polyethylene glycol 1000 and 12.5% (w/w) dibasic potassium phosphate system under 1000 rpm of column revolution. The 1.5 mm I.D., 2.5 mm O.D. locular tubing compressed at 2 cm intervals yielded better partition efficiencies than the non-clamped tubing using both lower and upper mobile phases with satisfactory retention of the stationary phase. The overall results suggest that the newly designed locular multilayer coil is useful to the preparative separation of proteins with aqueous-aqueous polymer phase system using our small-scale X-axis CPC.

Accidental genetic engineers: horizontal sequence transfer from parasitoid wasps to their Lepidopteran hosts.

Directory of Open Access Journals (Sweden)

Sean E Schneider

Full Text Available We show here that 105 regions in two Lepidoptera genomes appear to derive from horizontally transferred wasp DNA. We experimentally verified the presence of two of these sequences in a diverse set of silkworm (Bombyx mori genomes. We hypothesize that these horizontal transfers are made possible by the unusual strategy many parasitoid wasps employ of injecting hosts with endosymbiotic polydnaviruses to minimize the host's defense response. Because these virus-like particles deliver wasp DNA to the cells of the host, there has been much interest in whether genetic information can be permanently transferred from the wasp to the host. Two transferred sequences code for a BEN domain, known to be associated with polydnaviruses and transcriptional regulation. These findings represent the first documented cases of horizontal transfer of genes between two organisms by a polydnavirus. This presents an interesting evolutionary paradigm in which host species can acquire new sequences from parasitoid wasps that attack them. Hymenoptera and Lepidoptera diverged ∼300 MYA, making this type of event a source of novel sequences for recipient species. Unlike many other cases of horizontal transfer between two eukaryote species, these sequence transfers can be explained without the need to invoke the sequences 'hitchhiking' on a third organism (e.g. retrovirus capable of independent reproduction. The cellular machinery necessary for the transfer is contained entirely in the wasp genome. The work presented here is the first such discovery of what is likely to be a broader phenomenon among species affected by these wasps.

Korea's Horizontal and Vertical Intra-Industry Trade and FDI in Trade with East Asian Countries

Directory of Open Access Journals (Sweden)

Taegi Kim

2007-06-01

Full Text Available This paper examines Korea's intra-industry trade (IIT by disentangling vertical from horizontal IIT, and analyzes the determinants of both IIT types in trade with East Asian countries during the period of 1991-2005. Korea's IIT with East Asian countries has increased rapidly, especially its high quality IIT, which has increased faster than horizontal IIT and low quality IIT, implying that Korea's product quality has improved over time. Korea's high quality IIT is larger in trade with developing countries, but its low quality IIT is larger in trade with Japan. The regression results show that the income differences between countries have a negative effect on horizontal IIT, and that Korea's high quality IIT becomes larger when Korea's income is higher than the income of partner countries. This supports the theory of IIT. Foreign direct investment (FDI inflow has had a positive effect on increases in IIT, but the effects of FDI outflow are not certain. This suggests a policy implication that FDI inflow has a more positive effect on IIT than FDI outflow.

TU-FG-201-12: Designing a Risk-Based Quality Assurance Program for a Newly Implemented Y-90 Microspheres Procedure

Energy Technology Data Exchange (ETDEWEB)

Vile, D; Zhang, L; Cuttino, L; Kim, S; Palta, J [Virginia Commonwealth University, Richmond, VA (United States)

2016-06-15

Purpose: To create a quality assurance program based upon a risk-based assessment of a newly implemented SirSpheres Y-90 procedure. Methods: A process map was created for a newly implemented SirSpheres procedure at a community hospital. The process map documented each step of this collaborative procedure, as well as the roles and responsibilities of each member. From the process map, different potential failure modes were determined as well as any current controls in place. From this list, a full failure mode and effects analysis (FMEA) was performed by grading each failure mode’s likelihood of occurrence, likelihood of detection, and potential severity. These numbers were then multiplied to compute the risk priority number (RPN) for each potential failure mode. Failure modes were then ranked based on their RPN. Additional controls were then added, with failure modes corresponding to the highest RPNs taking priority. Results: A process map was created that succinctly outlined each step in the SirSpheres procedure in its current implementation. From this, 72 potential failure modes were identified and ranked according to their associated RPN. Quality assurance controls and safety barriers were then added for failure modes associated with the highest risk being addressed first. Conclusion: A quality assurance program was created from a risk-based assessment of the SirSpheres process. Process mapping and FMEA were effective in identifying potential high-risk failure modes for this new procedure, which were prioritized for new quality assurance controls. TG 100 recommends the fault tree analysis methodology to design a comprehensive and effective QC/QM program, yet we found that by simply introducing additional safety barriers to address high RPN failure modes makes the whole process simpler and safer.

TU-FG-201-12: Designing a Risk-Based Quality Assurance Program for a Newly Implemented Y-90 Microspheres Procedure

International Nuclear Information System (INIS)

Vile, D; Zhang, L; Cuttino, L; Kim, S; Palta, J

2016-01-01

Purpose: To create a quality assurance program based upon a risk-based assessment of a newly implemented SirSpheres Y-90 procedure. Methods: A process map was created for a newly implemented SirSpheres procedure at a community hospital. The process map documented each step of this collaborative procedure, as well as the roles and responsibilities of each member. From the process map, different potential failure modes were determined as well as any current controls in place. From this list, a full failure mode and effects analysis (FMEA) was performed by grading each failure mode’s likelihood of occurrence, likelihood of detection, and potential severity. These numbers were then multiplied to compute the risk priority number (RPN) for each potential failure mode. Failure modes were then ranked based on their RPN. Additional controls were then added, with failure modes corresponding to the highest RPNs taking priority. Results: A process map was created that succinctly outlined each step in the SirSpheres procedure in its current implementation. From this, 72 potential failure modes were identified and ranked according to their associated RPN. Quality assurance controls and safety barriers were then added for failure modes associated with the highest risk being addressed first. Conclusion: A quality assurance program was created from a risk-based assessment of the SirSpheres process. Process mapping and FMEA were effective in identifying potential high-risk failure modes for this new procedure, which were prioritized for new quality assurance controls. TG 100 recommends the fault tree analysis methodology to design a comprehensive and effective QC/QM program, yet we found that by simply introducing additional safety barriers to address high RPN failure modes makes the whole process simpler and safer.

Experimental study of improved HAWT performance in simulated natural wind by an active controlled multi-fan wind tunnel

Science.gov (United States)

Toshimitsu, Kazuhiko; Narihara, Takahiko; Kikugawa, Hironori; Akiyoshi, Arata; Kawazu, Yuuya

2017-04-01

The effects of turbulent intensity and vortex scale of simulated natural wind on performance of a horizontal axis wind turbine (HAWT) are mainly investigated in this paper. In particular, the unsteadiness and turbulence of wind in Japan are stronger than ones in Europe and North America in general. Hence, Japanese engineers should take account of the velocity unsteadiness of natural wind at installed open-air location to design a higher performance wind turbine. Using the originally designed five wind turbines on the basis of NACA and MEL blades, the dependencies of the wind frequency and vortex scale of the simulated natural wind are presented. As the results, the power coefficient of the newly designed MEL3-type rotor in the simulated natural wind is 130% larger than one in steady wind.

Low Carbon Design Research on the Space Layout Types of Office Buildings

Science.gov (United States)

Xia, Bing

2018-01-01

It is beneficial to find out the relationship of the spatial layout and low-carbon design in order to reduce buildings’ carbon emissions in the conceptual design phase. This paper analyzes and compares shape coefficient values, annual energy consumption and lighting performance of office buildings of different space layout types in Shanghai. Based on morphological characteristics of different types, the study also analyzes and presents low-carbon design strategies for each single type. This study assumes that architects should conduct passive and active design according to the specific building space layout, so that to make best use of the advantages and bypassing the disadvantages, in order to maximally reduce buildings’ carbon emissions.

Study on the relationship between changes of serum, adiponectin some inflammatory cytokines levels and insulin resistance in newly diagnosed type 2 diabetes mellitus patients

International Nuclear Information System (INIS)

Feng Kun; Wng Dan; Duan Binhong; Yang Yuzhi

2009-01-01

Objective: To study the relationship between changes of serum adiponectin,interleukin-6 (IL-6)tumor necrosis factor-α (TNF-α) levels and insulin resistance (IR), obesity parameters in newly diagnosed type 2 diabetes mellitus (DM2) patients. Methods: Serum adiponectin (with RIA), IL-6, TNF-α (with ELISA) levels as well as fBG, 2hPG, fasting insulin, 2h insulin, lipid profile were measured in 42 obese newly diagnosed DM2 patients (BMI>25), 50 non-obese DM2 patients (BMI<25) and 40 controls. Results: The levels of adiponectin obese group were significantly those in the other groups (P<0.05 and P<0.01), while levels in non-obese group were significantly lower than those in controls (P<0.01). The levels of IL-6 and TNF-α in obese group were significantly higher than those in the other groups (P<0.05 and P<0.01), while the levels in non-obese group were significantly higher than the levels in controls (P<0.01). The adiponectin levels were negatively correlated with insulin resistance(HOMA-IR) and BMI, while the cytokines levels were posisitively correlated with HOMA-IR and BMI. Conclusion: Adiponectin, IL-6 and TNF-α are closely related with insulin resistance, and take parts in development of the abnormal glucose metabolism. (authors)

The Danish Centre for Strategic Research in Type 2 Diabetes (DD2) Project

DEFF Research Database (Denmark)

Steffensen, Maria Charlotte; Thomsen, Reimar W; Vaag, Allan

2012-01-01

guidelines for maintaining metabolic control in newly diagnosed type 2 diabetes (T2D) patients to prevent diabetic complications and improve quality of life. The DD2 is designed as a prospective cohort study (collection of epidemiological data) supplemented by randomized clinical intervention trials (on...... physical exercise and individualized pharmacological treatment) and the establishment of a biobank comprised of material from a large number of newly diagnosed T2D patients. Inclusion of the majority of newly diagnosed T2D patients as they are diagnosed at their general practitioner or diabetes hospital...... outpatient clinics and entered into the DD2 cohort will establish a nationwide database comprising a large number of future incident cases of T2D in Denmark. These cases will form the project cohort of the DD2. Within the first 6 months of diagnosis, all patients will be invited to contribute to a biobank...

Horizontal impact testing of quarter scale flasks using masonry targets

International Nuclear Information System (INIS)

Tufton, E.P.S.

1985-01-01

The programme leading up to the Train Crash Demonstration included investigation of flask impacts, in horizontal motion, against masonry targets representing abutment structures. An outline is given of a series of eight tests, of which five are described in detail. All the tests used quarter-scale flasks, and the design and construction of the appropriate brick and stone masonry targets is described. A summary of results is given in terms of damage to the model flask compared with the more severe damage seen in regulatory drop tests. (author)

DOT-7A Type A packaging design guide

International Nuclear Information System (INIS)

Kelly, D.L.

1995-01-01

The purpose of this Design Guide is to provide instruction for designing a U.S. Department of Transportation Specification 7A (DOT-7A) Type A packaging. Another purpose for this Design Guide is to support the evaluation and testing activities that are performed on new designs by a U.S. Department of Energy (DOE) test facility. This evaluation and testing program is called the DOT-7A Program. When an applicant has determined that a DOT-7A packaging is needed and not commercially available, a design may be created according to this document. The design should include a packaging drawing, specifications, analysis report, operating instructions, and a Packaging Qualification Checklist; all of which should be forwarded to a DOE/HQ approved test facility for evaluation and testing. This report is being submitted through the Engineering Documentation System so that it may be used for reference and information purposes

Optimum Safety Levels and Design Rules for the Icelandic Type Berm Breakwater

DEFF Research Database (Denmark)

Sigurdarson, Sigurdur; van der Meer, Jentsje W.; Burcharth, Hans F.

2007-01-01

Guidance on selection of breakwater types and related design safety levels for breakwaters are almost non-existent, which is the reason that PIANC has initiated working group 47 on this subject. This paper presents ongoing work particulary on the Icelandic type berm breakwater within the PIANC...... working group. It will concentrate on design guidance and on the optimum safety levels for this type of structure....

Influence of pavement condition on horizontal curve safety.

Science.gov (United States)

Buddhavarapu, Prasad; Banerjee, Ambarish; Prozzi, Jorge A

2013-03-01

Crash statistics suggest that horizontal curves are the most vulnerable sites for crash occurrence. These crashes are often severe and many involve at least some level of injury due to the nature of the collisions. Ensuring the desired pavement surface condition is one potentially effective strategy to reduce the occurrence of severe accidents on horizontal curves. This study sought to develop crash injury severity models by integrating crash and pavement surface condition databases. It focuses on developing a causal relationship between pavement condition indices and severity level of crashes occurring on two-lane horizontal curves in Texas. In addition, it examines the suitability of the existing Skid Index for safety maintenance of two-lane curves. Significant correlation is evident between pavement condition and crash injury severity on two-lane undivided horizontal curves in Texas. Probability of a crash becoming fatal is appreciably sensitive to certain pavement indices. Data suggested that road facilities providing a smoother and more comfortable ride are vulnerable to severe crashes on horizontal curves. In addition, the study found that longitudinal skid measurement barely correlates with injury severity of crashes occurring on curved portions. The study recommends exploring the option of incorporating lateral friction measurement into Pavement Management System (PMS) databases specifically at curved road segments. Copyright © 2012 Elsevier Ltd. All rights reserved.

Immunoparesis in newly diagnosed Multiple Myeloma patients

DEFF Research Database (Denmark)