A long-period analog integrator for magnetic measurements in Tore Supra

International Nuclear Information System (INIS)

Prou, M.; Barth, E.; Couturier, P.; Ouvrier-Buffet, P.

1998-01-01

A new analog integrator, called 'Integrateur 2000', has been developed for precise integration over long periods for the magnetic signals of Tore Supra with the aim of 1000 s discharges for the CIEL project. This new integrator is already in routine use for the present pulse lengths of up to 200 s in T-S, and tests have been carried out up to 1000 s with less than 2 mV of drift. (author)

Relational integration, inhibition, and analogical reasoning in older adults.

Science.gov (United States)

Viskontas, Indre V; Morrison, Robert G; Holyoak, Keith J; Hummel, John E; Knowlton, Barbara J

2004-12-01

The difficulty of reasoning tasks depends on their relational complexity, which increases with the number of relations that must be considered simultaneously to make an inference, and on the number of irrelevant items that must be inhibited. The authors examined the ability of younger and older adults to integrate multiple relations and inhibit irrelevant stimuli. Young adults performed well at all but the highest level of relational complexity, whereas older adults performed poorly even at a medium level of relational complexity, especially when irrelevant information was presented. Simulations based on a neurocomputational model of analogical reasoning, Learning and Inference with Schemas and Analogies (LISA), suggest that the observed decline in reasoning performance may be explained by a decline in attention and inhibitory functions in older adults. copyright (c) 2004 APA, all rights reserved.

A Novel Analog Integrated Circuit Design Course Covering Design, Layout, and Resulting Chip Measurement

Science.gov (United States)

Lin, Wei-Liang; Cheng, Wang-Chuan; Wu, Chen-Hao; Wu, Hai-Ming; Wu, Chang-Yu; Ho, Kuan-Hsuan; Chan, Chueh-An

2010-01-01

This work describes a novel, first-year graduate-level analog integrated circuit (IC) design course. The course teaches students analog circuit design; an external manufacturer then produces their designs in three different silicon chips. The students, working in pairs, then test these chips to verify their success. All work is completed within…

Integrated Circuits for Analog Signal Processing

CERN Document Server

2013-01-01

  This book presents theory, design methods and novel applications for integrated circuits for analog signal processing.  The discussion covers a wide variety of active devices, active elements and amplifiers, working in voltage mode, current mode and mixed mode.  This includes voltage operational amplifiers, current operational amplifiers, operational transconductance amplifiers, operational transresistance amplifiers, current conveyors, current differencing transconductance amplifiers, etc.  Design methods and challenges posed by nanometer technology are discussed and applications described, including signal amplification, filtering, data acquisition systems such as neural recording, sensor conditioning such as biomedical implants, actuator conditioning, noise generators, oscillators, mixers, etc.   Presents analysis and synthesis methods to generate all circuit topologies from which the designer can select the best one for the desired application; Includes design guidelines for active devices/elements...

Using crosscorrelation to mitigate analog/RF impairments for integrated spectrum analyzers

NARCIS (Netherlands)

Oude Alink, M.S.; Klumperink, Eric A.M.; Kokkeler, Andre B.J.; Ru, Z.; Cheng, W.; Nauta, Bram

2013-01-01

An integrated spectrum analyzer is useful for built-in self-test purposes, software-defined radios, or dynamic spectrum access in cognitive radio. The analog/RF performance is impaired by a number of factors, including thermal noise, phase noise, and nonlinearity. In this paper, we present an

Digitally controlled analog proportional-integral-derivative (PID) controller for high-speed scanning probe microscopy

Science.gov (United States)

Dukic, Maja; Todorov, Vencislav; Andany, Santiago; Nievergelt, Adrian P.; Yang, Chen; Hosseini, Nahid; Fantner, Georg E.

2017-12-01

Nearly all scanning probe microscopes (SPMs) contain a feedback controller, which is used to move the scanner in the direction of the z-axis in order to maintain a constant setpoint based on the tip-sample interaction. The most frequently used feedback controller in SPMs is the proportional-integral (PI) controller. The bandwidth of the PI controller presents one of the speed limiting factors in high-speed SPMs, where higher bandwidths enable faster scanning speeds and higher imaging resolution. Most SPM systems use digital signal processor-based PI feedback controllers, which require analog-to-digital and digital-to-analog converters. These converters introduce additional feedback delays which limit the achievable imaging speed and resolution. In this paper, we present a digitally controlled analog proportional-integral-derivative (PID) controller. The controller implementation allows tunability of the PID gains over a large amplification and frequency range, while also providing precise control of the system and reproducibility of the gain parameters. By using the analog PID controller, we were able to perform successful atomic force microscopy imaging of a standard silicon calibration grating at line rates up to several kHz.

Design of a long pulse and low drift analog integrator in HT-7

International Nuclear Information System (INIS)

Liu Dongmei; Wan Baonian; Shen Biao

2007-01-01

Magnetic measurements are a fundamental diagnostic system for Tokamak. Inductive magnetic coils are used on HT-7. So the integrator is required to determine the magnetic field strength. This paper discusses the traditional analog integrator, and introduces a new integrator based on real-time drift compensation schemes. This new design can significantly reduce the integral error caused by input offset, temperature-induced drift, noise and so on. Operation in the HT-7 Tokamak shows that very low drift and noise characteristics compatible of the now integrators can meet requirement of long pulse discharges. (authors)

AMIC: an expandable integrated analog front-end for light distribution moments analysis

Energy Technology Data Exchange (ETDEWEB)

Spaggiari, M; Herrero, V; Lerche, C W; Aliaga, R; Monzo, J M; Gadea, R, E-mail: michele.spaggiari@gmail.com [Instituto de Instrumentacion para Imagen Molecular (I3M), Universidad Politecnica de Valencia, Camino de Vera, 46022, Valencia (Spain)

2011-01-15

In this article we introduce AMIC (Analog Moments Integrated Circuit), a novel analog Application Specific Integrated Circuit (ASIC) front-end for Positron Emission Tomography (PET) applications. Its working principle is based on mathematical analysis of light distribution through moments calculation. Each moment provides useful information about light distribution, such as energy, position, depth of interaction, skewness (deformation due to border effect) etc. A current buffer delivers a copy of each input current to several processing blocks. The current preamplifier is designed in order to achieve unconditional stability under high input capacitance, thus allowing the use of both Photo-Multiplier Tubes (PMT) and Silicon Photo-Multipliers (SiPM). Each processing block implements an analog current filtering by multiplying each input current by a programmable 8-bit coefficient. The latter is implemented through a high linear MOS current divider ladder, whose high sensitivity to variations in output voltages requires the integration of an extremely stable fully differential current collector. Output currents are then summed and sent to the output stage, that provides both a buffered output current and a linear rail-to-rail voltage for further digitalization. Since computation is purely additive, the 64 input channels of AMIC do not represent a limitation in the number of the detector's outputs. Current outputs of various AMIC structures can be combined as inputs of a final AMIC, thus providing a fully expandable structure. In this version of AMIC, 8 programmable blocks for moments calculation are integrated, as well as an I2C interface in order to program every coefficient. Extracted layout simulation results demonstrate that the information provided by moment calculation in AMIC helps to improve tridimensional positioning of the detected event. A two-detector test-bench is now being used for AMIC prototype characterization and preliminary results are presented.

Integrated electrofluidic circuits: pressure sensing with analog and digital operation functionalities for microfluidics.

Science.gov (United States)

Wu, Chueh-Yu; Lu, Jau-Ching; Liu, Man-Chi; Tung, Yi-Chung

2012-10-21

Microfluidic technology plays an essential role in various lab on a chip devices due to its desired advantages. An automated microfluidic system integrated with actuators and sensors can further achieve better controllability. A number of microfluidic actuation schemes have been well developed. In contrast, most of the existing sensing methods still heavily rely on optical observations and external transducers, which have drawbacks including: costly instrumentation, professional operation, tedious interfacing, and difficulties of scaling up and further signal processing. This paper reports the concept of electrofluidic circuits - electrical circuits which are constructed using ionic liquid (IL)-filled fluidic channels. The developed electrofluidic circuits can be fabricated using a well-developed multi-layer soft lithography (MSL) process with polydimethylsiloxane (PDMS) microfluidic channels. Electrofluidic circuits allow seamless integration of pressure sensors with analog and digital operation functions into microfluidic systems and provide electrical readouts for further signal processing. In the experiments, the analog operation device is constructed based on electrofluidic Wheatstone bridge circuits with electrical outputs of the addition and subtraction results of the applied pressures. The digital operation (AND, OR, and XOR) devices are constructed using the electrofluidic pressure controlled switches, and output electrical signals of digital operations of the applied pressures. The experimental results demonstrate the designed functions for analog and digital operations of applied pressures are successfully achieved using the developed electrofluidic circuits, making them promising to develop integrated microfluidic systems with capabilities of precise pressure monitoring and further feedback control for advanced lab on a chip applications.

An integrated analog O/E/O link for multi-channel laser neurons

Energy Technology Data Exchange (ETDEWEB)

Nahmias, Mitchell A., E-mail: mnahmias@princeton.edu; Tait, Alexander N.; Tolias, Leonidas; Chang, Matthew P.; Ferreira de Lima, Thomas; Shastri, Bhavin J.; Prucnal, Paul R. [Electrical Engineering Department, Princeton University, 41 Olden St, Princeton, New Jersey 08540 (United States)

2016-04-11

We demonstrate an analog O/E/O electronic link to allow integrated laser neurons to accept many distinguishable, high bandwidth input signals simultaneously. This device utilizes wavelength division multiplexing to achieve multi-channel fan-in, a photodetector to sum signals together, and a laser cavity to perform a nonlinear operation. Its speed outpaces accelerated-time neuromorphic electronics, and it represents a viable direction towards scalable networking approaches.

Development of an exergy-electrical analogy for visualizing and modeling building integrated energy systems

International Nuclear Information System (INIS)

Saloux, E.; Teyssedou, A.; Sorin, M.

2015-01-01

Highlights: • The exergy-electrical analogy is developed for energy systems used in buildings. • This analogy has been developed for a complete set of system arrangement options. • Different possibilities of inter-connections are illustrated using analog switches. • Adaptability and utility of the diagram over traditional ones are emphasized. - Abstract: An exergy-electrical analogy, similar to the heat transfer electrical one, is developed and applied to the case of integrated energy systems operating in buildings. Its construction is presented for the case of space heating with electric heaters, heat pumps and solar collectors. The proposed analogy has been applied to a set of system arrangement options proposed for satisfying the building heating demand (space heating, domestic hot water); different alternatives to connect the units have been presented with switches in a visualization scheme. The analogy for such situation has been performed and the study of a solar assisted heat pump using ice storage has been investigated. This diagram directly permits energy paths and their associated exergy destruction to be visualized; hence, sources of irreversibility are identifiable. It can be helpful for the comprehension of the global process and its operation as well as for identifying exergy losses. The method used to construct the diagram makes it easily adaptable to others units or structures or to others models depending on the complexity of the process. The use of switches could be very useful for optimization purposes

An analog memory integrated circuit for waveform sampling up to 900 MHz

International Nuclear Information System (INIS)

Haller, G.M.; Wooley, B.A.

1994-01-01

The potential of switched-capacitor technology for acquiring analog signals in high-energy physics (HEP) applications has been demonstrated in a number of analog memory designs. The design and implementation of a switched-capacitor memory suitable for capturing high-speed analog waveforms is described. Highlights of the presented circuit are a 900 MHz sampling frequency (generated on chip), input signal independent cell pedestal and sampling instances, and cell gains that are insensitive to component sizes. A two-channel version of the memory with 32 cells for each channel has been integrate in a 2-μm complementary metal oxide semiconductor (CMOS) process with polysilicon-to-polysilicon capacitors. The measured rms cell response variation in a channel after cell pedestal subtraction is less than 0.3 mV across the full input signal range. The cell-to-cell gain matching is better than 0.01% rms, and the nonlinearity is less than 0.03% for a 2.5-V input range. The dynamic range of the memory exceeds 13 bits, and the peak signal-to-(noise + distortion) ratio for a 21.4 MHz sine wave sampled at 900 MHz is 59 dB

Analog storage integrated circuit

Science.gov (United States)

Walker, J.T.; Larsen, R.S.; Shapiro, S.L.

1989-03-07

A high speed data storage array is defined utilizing a unique cell design for high speed sampling of a rapidly changing signal. Each cell of the array includes two input gates between the signal input and a storage capacitor. The gates are controlled by a high speed row clock and low speed column clock so that the instantaneous analog value of the signal is only sampled and stored by each cell on coincidence of the two clocks. 6 figs.

A bilateral frontoparietal network underlies visuospatial analogical reasoning.

Science.gov (United States)

Watson, Christine E; Chatterjee, Anjan

2012-02-01

Our ability to reason by analogy facilitates problem solving and allows us to communicate ideas efficiently. In this study, we examined the neural correlates of analogical reasoning and, more specifically, the contribution of rostrolateral prefrontal cortex (RLPFC) to reasoning. This area of the brain has been hypothesized to integrate relational information, as in analogy, or the outcomes of subgoals, as in multi-tasking and complex problem solving. Using fMRI, we compared visuospatial analogical reasoning to a control task that was as complex and difficult as the analogies and required the coordination of subgoals but not the integration of relations. We found that analogical reasoning more strongly activated bilateral RLPFC, suggesting that anterior prefrontal cortex is preferentially recruited by the integration of relational knowledge. Consistent with the need for inhibition during analogy, bilateral, and particularly right, inferior frontal gyri were also more active during analogy. Finally, greater activity in bilateral inferior parietal cortex during the analogy task is consistent with recent evidence for the neural basis of spatial relation knowledge. Together, these findings indicate that a network of frontoparietal areas underlies analogical reasoning; we also suggest that hemispheric differences may emerge depending on the visuospatial or verbal/semantic nature of the analogies. Copyright © 2011 Elsevier Inc. All rights reserved.

ESD analog circuits and design

CERN Document Server

Voldman, Steven H

2014-01-01

A comprehensive and in-depth review of analog circuit layout, schematic architecture, device, power network and ESD design This book will provide a balanced overview of analog circuit design layout, analog circuit schematic development, architecture of chips, and ESD design.  It will start at an introductory level and will bring the reader right up to the state-of-the-art. Two critical design aspects for analog and power integrated circuits are combined. The first design aspect covers analog circuit design techniques to achieve the desired circuit performance. The second and main aspect pres

High-precision analog circuit technology for power supply integrated circuits; Dengen IC yo koseido anarogu kairo gijutsu

Energy Technology Data Exchange (ETDEWEB)

Nakamori, A.; Suzuki, T.; Mizoe, K. [Fuji Electric Corporate Research and Development,Ltd., Kanagawa (Japan)

2000-08-10

With the recent rapid spread of portable electronic appliances, specification requirements such as compact power supply and long operation with batteries have become severer. Power supply ICs (integrated circuits) are required to reduce power consumption in the circuit and perform high-precision control. To meet these requirements, Fuji Electric develops high-precision CMOS (complementary metal-oxide semiconductor) analog technology. This paper describes three analog circuit technologies of a voltage reference, an operational amplifier and a comparator as circuit components particularly important for the precision of power supply ICs. (author)

Design of an integrated analog controller for a Class-D Audio Amplifier

OpenAIRE

Verbrugghe, Jochen; De Bock, Maarten; Rombouts, Pieter

2009-01-01

An integrated analog controller for a self-oscillating class-D audio power amplifier is designed in a 0.35 μm CMOS technology for a 3.3 Volt power supply. It is intended to be used with an external output stage and passive filter, for medium power applications of upto a few 100 Watts. The controller was optimized with regard to its loop gain to suppress the distortion of the output stage. In typical commercially available output stages, the distortion is dominated by dead time effects and th...

Design and Analysis of Reconfigurable Analog System

Science.gov (United States)

2011-02-01

34010010" �" �" �" �" �" �" �±" N3 N2 N± P1 P2 P3 * Current sources $RR = 1; *Ramp Rate (slope of the...2008/12/12/31e83bac-500f-4182- acca -4d360295fd9c.pdf, Analog Devices, Analog Dialogue 39-06, June 2005. [15] D. A. Johns, K. Martin "Analog Integrated

Advances in Analog Circuit Design 2015

CERN Document Server

Baschirotto, Andrea; Harpe, Pieter

2016-01-01

This book is based on the 18 tutorials presented during the 24th workshop on Advances in Analog Circuit Design. Expert designers present readers with information about a variety of topics at the frontier of analog circuit design, including low-power and energy-efficient analog electronics, with specific contributions focusing on the design of efficient sensor interfaces and low-power RF systems. This book serves as a valuable reference to the state-of-the-art, for anyone involved in analog circuit research and development. ·         Provides a state-of-the-art reference in analog circuit design, written by experts from industry and academia; ·         Presents material in a tutorial-based format; ·         Includes coverage of high-performance analog-to-digital and digital to analog converters, integrated circuit design in scaled technologies, and time-domain signal processing.

Neural correlates of creativity in analogical reasoning.

Science.gov (United States)

Green, Adam E; Kraemer, David J M; Fugelsang, Jonathan A; Gray, Jeremy R; Dunbar, Kevin N

2012-03-01

Brain-based evidence has implicated the frontal pole of the brain as important for analogical mapping. Separately, cognitive research has identified semantic distance as a key determinant of the creativity of analogical mapping (i.e., more distant analogies are generally more creative). Here, we used functional magnetic resonance imaging to assess brain activity during an analogy generation task in which we varied the semantic distance of analogical mapping (as derived quantitatively from a latent semantic analysis). Data indicated that activity within an a priori region of interest in left frontopolar cortex covaried parametrically with increasing semantic distance, even after removing effects of task difficulty. Results implicate increased recruitment of frontopolar cortex as a mechanism for integrating semantically distant information to generate solutions in creative analogical reasoning. 2012 APA, all rights reserved

CMOS analog circuit design

CERN Document Server

Allen, Phillip E

1987-01-01

This text presents the principles and techniques for designing analog circuits to be implemented in a CMOS technology. The level is appropriate for seniors and graduate students familiar with basic electronics, including biasing, modeling, circuit analysis, and some familiarity with frequency response. Students learn the methodology of analog integrated circuit design through a hierarchically-oriented approach to the subject that provides thorough background and practical guidance for designing CMOS analog circuits, including modeling, simulation, and testing. The authors' vast industrial experience and knowledge is reflected in the circuits, techniques, and principles presented. They even identify the many common pitfalls that lie in the path of the beginning designer--expert advice from veteran designers. The text mixes the academic and practical viewpoints in a treatment that is neither superficial nor overly detailed, providing the perfect balance.

Structure problems in the analog computation

International Nuclear Information System (INIS)

Braffort, P.L.

1957-01-01

The recent mathematical development showed the importance of elementary structures (algebraic, topological, etc.) in abeyance under the great domains of classical analysis. Such structures in analog computation are put in evidence and possible development of applied mathematics are discussed. It also studied the topological structures of the standard representation of analog schemes such as additional triangles, integrators, phase inverters and functions generators. The analog method gives only the function of the variable: time, as results of its computations. But the course of computation, for systems including reactive circuits, introduces order structures which are called 'chronological'. Finally, it showed that the approximation methods of ordinary numerical and digital computation present the same structure as these analog computation. The structure analysis permits fruitful comparisons between the several domains of applied mathematics and suggests new important domains of application for analog method. (M.P.)

A bipolar analog front-end integrated circuit for the SDC silicon tracker

International Nuclear Information System (INIS)

Kipnis, I.; Spieler, H.; Collins, T.

1993-11-01

A low-noise, low-power, high-bandwidth, radiation hard, silicon bipolar-transistor full-custom integrated circuit (IC) containing 64 channels of analog signal processing has been developed for the SDC silicon tracker. The IC was designed and tested at LBL and was fabricated using AT ampersand T's CBIC-U2, 4 GHz f T complementary bipolar technology. Each channel contains the following functions: low-noise preamplification, pulse shaping and threshold discrimination. This is the first iteration of the production analog IC for the SDC silicon tracker. The IC is laid out to directly match the 50 μm pitch double-sided silicon strip detector. The chip measures 6.8 mm x 3.1 mm and contains 3,600 transistors. Three stages of amplification provide 180 mV/fC of gain with a 35 nsec peaking time at the comparator input. For a 14 pF detector capacitance, the equivalent noise charge is 1300 el. rms at a power consumption of 1 mW/channel from a single 3.5 V supply. With the discriminator threshold set to 4 times the noise level, a 16 nsec time-walk for 1.25 to 10fC signals is achieved using a time-walk compensation network. Irradiation tests at TRIUMF to a Φ=10 14 protons/cm 2 have been performed on the IC, demonstrating the radiation hardness of the complementary bipolar process

Low-voltage current-mode CMOS building blocks for field programmable analog arrays and application

International Nuclear Information System (INIS)

Madian, A.H.K.

2007-01-01

The role of analog integrated circuits in modem electronic systems remains important, even though digital circuits dominate the market for VLSI solutions. Analog systems have always played an essential role in interfacing digital electronics to the real world in applications such as analog signal processing and signal conditioning .Industrial process and motion control and biomedical measurements . In addition, analog solutions are becoming increasingly competitive with digital circuits for dense, low-power, high-speed applications in low-precision signal-processing. Because of the wide variety of analog functions required in electronic systems and the complexity of the signals (frequency, time, signal levels, parasitic), analog system design is very specialized and supported by a diverse set of CAD tools that are more difficult to integrate than those required for digital design. The drive towards shorter design cycles for analog integrated circuits has demanded the development of high performance analog circuits that are re configurable and suitable for CAD methodologies. the researcher here try to contribute in this filed

Analog-to-digital conversion using custom CMOS analog memory for the EOS time projection chamber

International Nuclear Information System (INIS)

Lee, K.L.; Arthur, A.A.; Jones, R.W.; Matis, H.S.; Nakamura, M.; Kleinfelder, S.A.; Ritter, H.G.; Wienman, H.H.

1990-01-01

This paper describes the multiplexing scheme of custom CMOS analog memory integrated circuits, 16 channels x 256 cells, into analog to digital converters (ADC's) to handle 15,360 signal channels of a time projection, chamber detector system. Primary requirements of this system are high density, low power and large dynamic range. The analog memory device multiplexing scheme was designed to digitize the information stored in the memory cells. The digitization time of the ADC's and the settling times for the memory unit were carefully interleaved to optimize the performance and timing during the multiplexing operation. This kept the total number of ADC's, a costly and power dissipative component, to an acceptable minimum

CMOS Analog IC Design: Fundamentals

OpenAIRE

Bruun, Erik

2018-01-01

This book is intended for use as the main textbook for an introductory course in CMOS analog integrated circuit design. It is aimed at electronics engineering students who have followed basic courses in mathematics, physics, circuit theory, electronics and signal processing. It takes the students directly from a basic level to a level where they can start working on simple analog IC design projects or continue their studies using more advanced textbooks in the field. A distinct feature of thi...

Computer-integrated environments for electronics problem by means of the analog simulator PSPICE; Komp`yuterno-integrirovannye sredy dlya problemnogo obucheniya po ehlektronike na osnove analogovogo simulyatora PSPICE

Energy Technology Data Exchange (ETDEWEB)

Mileva, I; Petrov, A; Pavlov, I [Plovdivskij Univ., Plovdiv (Bulgaria)

1996-12-31

For the problem teaching purpose the computer-integrated environments are developed for simulation of electronic circuits. CIE for study of typical analog electronic circuits called STUDENT`s MODULE are described. Simulation of electronic circuits carried out by means of the analog simulator PSPICE. 9 refs.; 3 figs.

23rd workshop on Advances in Analog Circuit Design

CERN Document Server

Baschirotto, Andrea; Makinwa, Kofi

2015-01-01

This book is based on the 18 tutorials presented during the 23rd workshop on Advances in Analog Circuit Design.  Expert designers present readers with information about a variety of topics at the frontier of analog circuit design, serving as a valuable reference to the state-of-the-art, for anyone involved in analog circuit research and development.    • Includes coverage of high-performance analog-to-digital and digital to analog converters, integrated circuit design in scaled technologies, and time-domain signal processing; • Provides a state-of-the-art reference in analog circuit design, written by experts from industry and academia; • Presents material in a tutorial-based format.

Analog and digital signal analysis from basics to applications

CERN Document Server

Cohen Tenoudji, Frédéric

2016-01-01

This book provides comprehensive, graduate-level treatment of analog and digital signal analysis suitable for course use and self-guided learning. This expert text guides the reader from the basics of signal theory through a range of application tools for use in acoustic analysis, geophysics, and data compression. Each concept is introduced and explained step by step, and the necessary mathematical formulae are integrated in an accessible and intuitive way. The first part of the book explores how analog systems and signals form the basics of signal analysis. This section covers Fourier series and integral transforms of analog signals, Laplace and Hilbert transforms, the main analog filter classes, and signal modulations. Part II covers digital signals, demonstrating their key advantages. It presents z and Fourier transforms, digital filtering, inverse filters, deconvolution, and parametric modeling for deterministic signals. Wavelet decomposition and reconstruction of non-stationary signals are also discussed...

Integrated Sedimentological Approach to Assess Reservoir Quality and Architecture of Khuff Carbonates: Outcrop Analog, Central Saudi Arabia

Science.gov (United States)

Osman, Mutsim; Abdullatif, Osman

2017-04-01

The Permian to Triassic Khuff carbonate reservoirs (and equivalents) in the Middle East are estimated to contain about 38.4% of the world's natural gas reserves. Excellent exposed outcrops in central Saudi Arabia provide good outcrop equivalents to subsurface Khuff reservoirs. This study conduct high resolution outcrop scale investigations on an analog reservoir for upper Khartam of Khuff Formation. The main objective is to reconstruct litho- and chemo- stratigraphic outcrop analog model that may serve to characterize reservoir high resolution (interwell) heterogeneity, continuity and architecture. Given the fact of the limitation of subsurface data and toolsin capturing interwell reservoir heterogeneity, which in turn increases the value of this study.The methods applied integrate sedimentological, stratigraphic petrographic, petrophysical data and chemical analyses for major, trace and rare earth elements. In addition, laser scanning survey (LIDAR) was also utilized in this study. The results of the stratigraphic investigations revealed that the lithofacies range from mudstone, wackestone, packestone and grainstone. These lithofacies represent environments ranging from supratidal, intertidal, subtidal and shoal complex. Several meter-scale and less high resolution sequences and composite sequences within 4th and 5th order cycles were also recognized in the outcrop analog. The lithofacies and architectural analysis revealed several vertically and laterally stacked sequences at the outcrop as revealed from the stratigraphic sections and the lidar scan. Chemostratigraphy is effective in identifying lithofacies and sequences within the outcrop analog. Moreover, different chemical signatures were also recognized and allowed establishing and correlating high resolution lithofacies, reservoir zones, layers and surfaces bounding reservoirs and non-reservoir zones at scale of meters or less. The results of this high resolution outcrop analog study might help to understand

Non-analog Monte Carlo estimators for radiation momentum deposition

International Nuclear Information System (INIS)

Hykes, Joshua M.; Densmore, Jeffery D.

2009-01-01

The standard method for calculating radiation momentum deposition in Monte Carlo simulations is the analog estimator, which tallies the change in a particle's momentum at each interaction with the matter. Unfortunately, the analog estimator can suffer from large amounts of statistical error. In this paper, we present three new non-analog techniques for estimating momentum deposition. Specifically, we use absorption, collision, and track-length estimators to evaluate a simple integral expression for momentum deposition that does not contain terms that can cause large amounts of statistical error in the analog scheme. We compare our new non-analog estimators to the analog estimator with a set of test problems that encompass a wide range of material properties and both isotropic and anisotropic scattering. In nearly all cases, the new non-analog estimators outperform the analog estimator. The track-length estimator consistently yields the highest performance gains, improving upon the analog-estimator figure of merit by factors of up to two orders of magnitude.

Technology under Moon and Mars Analog Missions Activities (MMAMA)

Data.gov (United States)

National Aeronautics and Space Administration — NASA Analog Missions research addresses the need for integrated interdisciplinary field experiments as an integral part of preparation for planned human and robotic...

Analog electronics for radiation detection

CERN Document Server

2016-01-01

Analog Electronics for Radiation Detection showcases the latest advances in readout electronics for particle, or radiation, detectors. Featuring chapters written by international experts in their respective fields, this authoritative text: Defines the main design parameters of front-end circuitry developed in microelectronics technologies Explains the basis for the use of complementary metal oxide semiconductor (CMOS) image sensors for the detection of charged particles and other non-consumer applications Delivers an in-depth review of analog-to-digital converters (ADCs), evaluating the pros and cons of ADCs integrated at the pixel, column, and per-chip levels Describes incremental sigma delta ADCs, time-to-digital converter (TDC) architectures, and digital pulse-processing techniques complementary to analog processing Examines the fundamental parameters and front-end types associated with silicon photomultipliers used for single visible-light photon detection Discusses pixel sensors ...

Silicon analog components device design, process integration, characterization, and reliability

CERN Document Server

El-Kareh, Badih

2015-01-01

This book covers modern analog components, their characteristics, and interactions with process parameters. It serves as a comprehensive guide, addressing both the theoretical and practical aspects of modern silicon devices and the relationship between their electrical properties and processing conditions. Based on the authors’ extensive experience in the development of analog devices, this book is intended for engineers and scientists in semiconductor research, development and manufacturing. The problems at the end of each chapter and the numerous charts, figures and tables also make it appropriate for use as a text in graduate and advanced undergraduate courses in electrical engineering and materials science.

Advances in analog and RF IC design for wireless communication systems

CERN Document Server

Manganaro, Gabriele

2013-01-01

Advances in Analog and RF IC Design for Wireless Communication Systems gives technical introductions to the latest and most significant topics in the area of circuit design of analog/RF ICs for wireless communication systems, emphasizing wireless infrastructure rather than handsets. The book ranges from very high performance circuits for complex wireless infrastructure systems to selected highly integrated systems for handsets and mobile devices. Coverage includes power amplifiers, low-noise amplifiers, modulators, analog-to-digital converters (ADCs) and digital-to-analog converters

High speed, wide dynamic range analog signal processing for avalanche photodiode

CERN Document Server

Walder, J P; Pangaud, P

2000-01-01

A wide dynamic range multi-gain analog transimpedance amplifier integrated circuit has been developed for avalanche photodiode signal processing. The 96 dB input dynamic range is divided into four ranges of 12-bits each in order to provide 40 MHz analog sampled data to a 12-bits ADC. This concept which has been integrated in both BiCMOS and full complementary bipolar technology along with fitted design techniques will be presented.

High speed, wide dynamic range analog signal processing for avalanche photodiode

International Nuclear Information System (INIS)

Walder, J.P.; El Mamouni, Houmani; Pangaud, Patrick

2000-01-01

A wide dynamic range multi-gain analog transimpedance amplifier integrated circuit has been developed for avalanche photodiode signal processing. The 96 dB input dynamic range is divided into four ranges of 12-bits each in order to provide 40 MHz analog sampled data to a 12-bits ADC. This concept which has been integrated in both BiCMOS and full complementary bipolar technology along with fitted design techniques will be presented

High speed, wide dynamic range analog signal processing for avalanche photodiode

Energy Technology Data Exchange (ETDEWEB)

Walder, J.P. E-mail: walder@in2p3.fr; El Mamouni, Houmani; Pangaud, Patrick

2000-03-11

A wide dynamic range multi-gain analog transimpedance amplifier integrated circuit has been developed for avalanche photodiode signal processing. The 96 dB input dynamic range is divided into four ranges of 12-bits each in order to provide 40 MHz analog sampled data to a 12-bits ADC. This concept which has been integrated in both BiCMOS and full complementary bipolar technology along with fitted design techniques will be presented.

Analogical reasoning: An incremental or insightful process? What cognitive and cortical evidence suggests.

Science.gov (United States)

Antonietti, Alessandro; Balconi, Michela

2010-06-01

Abstract The step-by-step, incremental nature of analogical reasoning can be questioned, since analogy making appears to be an insight-like process. This alternative view of analogical thinking can be integrated in Speed's model, even though the alleged role played by dopaminergic subcortical circuits needs further supporting evidence.

Detecting analogical resemblance without retrieving the source analogy.

Science.gov (United States)

Kostic, Bogdan; Cleary, Anne M; Severin, Kaye; Miller, Samuel W

2010-06-01

We examined whether people can detect analogical resemblance to an earlier experimental episode without being able to recall the experimental source of the analogical resemblance. We used four-word analogies (e.g., robin-nest/beaver-dam), in a variation of the recognition-without-cued-recall method (Cleary, 2004). Participants studied word pairs (e.g., robin-nest) and were shown new word pairs at test, half of which analogically related to studied word pairs (e.g., beaver-dam) and half of which did not. For each test pair, participants first attempted to recall an analogically similar pair from the study list. Then, regardless of whether successful recall occurred, participants were prompted to rate the familiarity of the test pair, which was said to indicate the likelihood that a pair that was analogically similar to the test pair had been studied. Across three experiments, participants demonstrated an ability to detect analogical resemblance without recalling the source analogy. Findings are discussed in terms of their potential relevance to the study of analogical reasoning and insight, as well as to the study of familiarity and recognition memory.

An analog front-end bipolar-transistor integrated circuit for the SDC silicon tracker

International Nuclear Information System (INIS)

Kipnis, I.; Spieler, H.; Collins, T.

1994-01-01

Since 1989 the Solenoidal Detector Collaboration (SDC) has been developing a general purpose detector to be operated at the Superconducting Super Collider (SSC). A low-noise, low-power, high-bandwidth, radiation hard, silicon bipolar-transistor full-custom integrated circuit (IC) containing 64 channels of analog signal processing has been developed for the SDS silicon tracker. The IC was designed and tested at LBL and was fabricated using AT and T's CBIC-U2, 4 GHz f T complementary bipolar technology. Each channel contains the following functions: low-noise preamplification, pulse shaping and threshold discrimination. This is the first iteration of the production analog IC for the SDC silicon tracker. The IC is laid out to directly match the 50 μm pitch double-sided silicon strip detector. The chip measures 6.8 mm x 3.1 mm and contains 3,600 transistors. Three stages of amplification provide 180 mV/fC of gain with a 35 nsec peaking time at the comparator input. For a 14 pF detector capacitance, the equivalent noise charge is 1300 el. rms at a power consumption of 1 mW/channel from a single 3.5 V supply. With the discriminator threshold set to 4 times the noise level, a 16nsec time-walk for 1.25 to 10 fC signals is achieved using a time-walk compensation network. Irradiation tests at TRIUMF to a φ = 10 14 protons/cm 2 have been performed on the JC, demonstrating the radiation hardness of the complementary bipolar process

Wafer-level chip-scale packaging analog and power semiconductor applications

CERN Document Server

Qu, Shichun

2015-01-01

This book presents a state-of-art and in-depth overview in analog and power WLCSP design, material characterization, reliability, and modeling. Recent advances in analog and power electronic WLCSP packaging are presented based on the development of analog technology and power device integration. The book covers in detail how advances in semiconductor content, analog and power advanced WLCSP design, assembly, materials, and reliability have co-enabled significant advances in fan-in and fan-out with redistributed layer (RDL) of analog and power device capability during recent years. Along with new analog and power WLCSP development, the role of modeling is a key to assure successful package design. An overview of the analog and power WLCSP modeling and typical thermal, electrical, and stress modeling methodologies is also provided. This book also: ·         Covers the development of wafer-level power discrete packaging with regular wafer-level design concepts and directly bumping technology ·    �...

An integrated multichannel neural recording analog front-end ASIC with area-efficient driven right leg circuit.

Science.gov (United States)

Tao Tang; Wang Ling Goh; Lei Yao; Jia Hao Cheong; Yuan Gao

2017-07-01

This paper describes an integrated multichannel neural recording analog front end (AFE) with a novel area-efficient driven right leg (DRL) circuit to improve the system common mode rejection ratio (CMRR). The proposed AFE consists of an AC-coupled low-noise programmable-gain amplifier, an area-efficient DRL block and a 10-bit SAR ADC. Compared to conventional DRL circuit, the proposed capacitor-less DRL design achieves 90% chip area reduction with enhanced CMRR performance, making it ideal for multichannel biomedical recording applications. The AFE circuit has been designed in a standard 0.18-μm CMOS process. Post-layout simulation results show that the AFE provides two gain settings of 54dB/60dB while consuming 1 μA per channel under a supply voltage of 1 V. The input-referred noise of the AFE integrated from 1 Hz to 10k Hz is only 4 μVrms and the CMRR is 110 dB.

Integrating Problem Solvers from Analogous Markets in New Product Ideation

DEFF Research Database (Denmark)

Franke, Nikolaus; Poetz, Marion; Schreier, Martin

2014-01-01

Who provides better inputs to new product ideation tasks, problem solvers with expertise in the area for which new products are to be developed or problem solvers from “analogous” markets that are distant but share an analogous problem or need? Conventional wisdom appears to suggest that target...... market expertise is indispensable, which is why most managers searching for new ideas tend to stay within their own market context even when they do search outside their firms' boundaries. However, in a unique symmetric experiment that isolates the effect of market origin, we find evidence...... for the opposite: Although solutions provided by problem solvers from analogous markets show lower potential for immediate use, they demonstrate substantially higher levels of novelty. Also, compared to established novelty drivers, this effect appears highly relevant from a managerial perspective: we find...

Development of reconfigurable analog and digital circuits for plasma diagnostics measurement systems

International Nuclear Information System (INIS)

Srivastava, Amit Kumar; Sharma, Atish; Raval, Tushar

2009-01-01

In long pulse discharge tokamak, a large number of diagnostic channels are being used to understand the complex behavior of plasma. Different diagnostics demand different types of analog and digital processing for plasma parameters measurement. This leads to variable requirements of signal processing for diagnostic measurement. For such types of requirements, we have developed hardware with reconfigurable electronic devices, which provide flexible solution for rapid development of measurement system. Here the analog processing is achieved by Field Programmable Analog Array (FPAA) integrated circuit while reconfigurable digital devices (CPLD/FPGA) achieve digital processing. FPAA's provide an ideal integrated platform for implementing low to medium complexity analog signal processing. With dynamic reconfigurability, the functionality of the FPAA can be reconfigured in-system by the designer or on the fly by a microprocessor. This feature is quite useful to manipulate the tuning or the construction of any part of the analog circuit without interrupting operation of the FPAA, thus maintaining system integrity. The hardware operation control logic circuits are configured in the reconfigurable digital devices (CPLD/FPGA) to control proper hardware functioning. These reconfigurable devices provide the design flexibility and save the component space on the board. It also provides the flexibility for various setting through software. The circuit controlling commands are either issued by computer/processor or generated by circuit itself. (author)

Electronic devices for analog signal processing

CERN Document Server

Rybin, Yu K

2012-01-01

Electronic Devices for Analog Signal Processing is intended for engineers and post graduates and considers electronic devices applied to process analog signals in instrument making, automation, measurements, and other branches of technology. They perform various transformations of electrical signals: scaling, integration, logarithming, etc. The need in their deeper study is caused, on the one hand, by the extension of the forms of the input signal and increasing accuracy and performance of such devices, and on the other hand, new devices constantly emerge and are already widely used in practice, but no information about them are written in books on electronics. The basic approach of presenting the material in Electronic Devices for Analog Signal Processing can be formulated as follows: the study with help from self-education. While divided into seven chapters, each chapter contains theoretical material, examples of practical problems, questions and tests. The most difficult questions are marked by a diamon...

Analogical scaffolding: Making meaning in physics through representation and analogy

Science.gov (United States)

Podolefsky, Noah Solomon

This work reviews the literature on analogy, introduces a new model of analogy, and presents a series of experiments that test and confirm the utility of this model to describe and predict student learning in physics with analogy. Pilot studies demonstrate that representations (e.g., diagrams) can play a key role in students' use of analogy. A new model of analogy, Analogical Scaffolding, is developed to explain these initial empirical results. This model will be described in detail, and then applied to describe and predict the outcomes of further experiments. Two large-scale (N>100) studies will demonstrate that: (1) students taught with analogies, according to the Analogical Scaffolding model, outperform students taught without analogies on pre-post assessments focused on electromagnetic waves; (2) the representational forms used to teach with analogy can play a significant role in student learning, with students in one treatment group outperforming students in other treatment groups by factors of two or three. It will be demonstrated that Analogical Scaffolding can be used to predict these results, as well as finer-grained results such as the types of distracters students choose in different treatment groups, and to describe and analyze student reasoning in interviews. Abstraction in physics is reconsidered using Analogical Scaffolding. An operational definition of abstraction is developed within the Analogical Scaffolding framework and employed to explain (a) why physicists consider some ideas more abstract than others in physics, and (b) how students conceptions of these ideas can be modeled. This new approach to abstraction suggests novel approaches to curriculum design in physics using Analogical Scaffolding.

Analogy, explanation, and proof

Science.gov (United States)

Hummel, John E.; Licato, John; Bringsjord, Selmer

2014-01-01

People are habitual explanation generators. At its most mundane, our propensity to explain allows us to infer that we should not drink milk that smells sour; at the other extreme, it allows us to establish facts (e.g., theorems in mathematical logic) whose truth was not even known prior to the existence of the explanation (proof). What do the cognitive operations underlying the inference that the milk is sour have in common with the proof that, say, the square root of two is irrational? Our ability to generate explanations bears striking similarities to our ability to make analogies. Both reflect a capacity to generate inferences and generalizations that go beyond the featural similarities between a novel problem and familiar problems in terms of which the novel problem may be understood. However, a notable difference between analogy-making and explanation-generation is that the former is a process in which a single source situation is used to reason about a single target, whereas the latter often requires the reasoner to integrate multiple sources of knowledge. This seemingly small difference poses a challenge to the task of marshaling our understanding of analogical reasoning to understanding explanation. We describe a model of explanation, derived from a model of analogy, adapted to permit systematic violations of this one-to-one mapping constraint. Simulation results demonstrate that the resulting model can generate explanations for novel explananda and that, like the explanations generated by human reasoners, these explanations vary in their coherence. PMID:25414655

Analogy, Explanation, and Proof

Directory of Open Access Journals (Sweden)

John eHummel

2014-11-01

Full Text Available People are habitual explanation generators. At its most mundane, our propensity to explain allows us to infer that we should not drink milk that smells sour; at the other extreme, it allows us to establish facts (e.g., theorems in mathematical logic whose truth was not even known prior to the existence of the explanation (proof. What do the cognitive operations underlying the (inductive inference that the milk is sour have in common with the (deductive proof that, say, the square root of two is irrational? Our ability to generate explanations bears striking similarities to our ability to make analogies. Both reflect a capacity to generate inferences and generalizations that go beyond the featural similarities between a novel problem and familiar problems in terms of which the novel problem may be understood. However, a notable difference between analogy-making and explanation-generation is that the former is a process in which a single source situation is used to reason about a single target, whereas the latter often requires the reasoner to integrate multiple sources of knowledge. This small-seeming difference poses a challenge to the task of marshaling our understanding of analogical reasoning in the service of understanding explanation. We describe a model of explanation, derived from a model of analogy, adapted to permit systematic violations of this one-to-one mapping constraint. Simulation results demonstrate that the resulting model can generate explanations for novel explananda and that, like the explanations generated by human reasoners, these explanations vary in their coherence.

An analog silicon retina with multichip configuration.

Science.gov (United States)

Kameda, Seiji; Yagi, Tetsuya

2006-01-01

The neuromorphic silicon retina is a novel analog very large scale integrated circuit that emulates the structure and the function of the retinal neuronal circuit. We fabricated a neuromorphic silicon retina, in which sample/hold circuits were embedded to generate fluctuation-suppressed outputs in the previous study [1]. The applications of this silicon retina, however, are limited because of a low spatial resolution and computational variability. In this paper, we have fabricated a multichip silicon retina in which the functional network circuits are divided into two chips: the photoreceptor network chip (P chip) and the horizontal cell network chip (H chip). The output images of the P chip are transferred to the H chip with analog voltages through the line-parallel transfer bus. The sample/hold circuits embedded in the P and H chips compensate for the pattern noise generated on the circuits, including the analog communication pathway. Using the multichip silicon retina together with an off-chip differential amplifier, spatial filtering of the image with an odd- and an even-symmetric orientation selective receptive fields was carried out in real time. The analog data transfer method in the present multichip silicon retina is useful to design analog neuromorphic multichip systems that mimic the hierarchical structure of neuronal networks in the visual system.

Performance of the Analog Moving Window Detector

DEFF Research Database (Denmark)

Hansen, V. Gregers

1970-01-01

A type of analog integrating moving window detector for use with a scanning pulse radar is examined. A performance analysis is carried out, which takes into account both the radiation pattern of the antenna and the dynamic character of the detection process due to the angular scanning...

Detecting analogies unconsciously

Directory of Open Access Journals (Sweden)

Thomas Peter Reber

2014-01-01

Full Text Available Analogies may arise from the conscious detection of similarities between a present and a past situation. In this functional magnetic resonance imaging study, we tested whether young volunteers would detect analogies unconsciously between a current supraliminal (visible and a past subliminal (invisible situation. The subliminal encoding of the past situation precludes awareness of analogy detection in the current situation. First, participants encoded subliminal pairs of unrelated words in either one or nine encoding trials. Later, they judged the semantic fit of supraliminally presented new words that either retained a previously encoded semantic relation (‘analog’ or not (‘broken analog’. Words in analogs versus broken analogs were judged closer semantically, which reflects unconscious analogy detection. Hippocampal activity associated with subliminal encoding correlated with the behavioral measure of unconscious analogy detection. Analogs versus broken analogs were processed with reduced prefrontal but enhanced medial temporal activity. We conclude that analogous episodes can be detected even unconsciously drawing on the episodic memory network.

The Feynman fluid analogy in e+e- annihilation

International Nuclear Information System (INIS)

Hegyi, S.; Krasznovszky, S.

1990-07-01

An analysis of the charged particle multiplicity distributions observed in e + e - annihilation is given using the generalized Feynman fluid analogy of multiparticle production. Only the two-and three-particle integrated correlation functions are included into the scheme. It is shown that the model correctly describes the available experimental data from the TASSO and HRS collaborations. Some properties of the fluid of the analogy are computed and a prediction is made for the multiplicity distribution at √s = 91 GeV. (author) 19 refs.; 5 figs.; 1 tab

Neuromimetic Circuits with Synaptic Devices Based on Strongly Correlated Electron Systems

Science.gov (United States)

Ha, Sieu D.; Shi, Jian; Meroz, Yasmine; Mahadevan, L.; Ramanathan, Shriram

2014-12-01

Strongly correlated electron systems such as the rare-earth nickelates (R NiO3 , R denotes a rare-earth element) can exhibit synapselike continuous long-term potentiation and depression when gated with ionic liquids; exploiting the extreme sensitivity of coupled charge, spin, orbital, and lattice degrees of freedom to stoichiometry. We present experimental real-time, device-level classical conditioning and unlearning using nickelate-based synaptic devices in an electronic circuit compatible with both excitatory and inhibitory neurons. We establish a physical model for the device behavior based on electric-field-driven coupled ionic-electronic diffusion that can be utilized for design of more complex systems. We use the model to simulate a variety of associate and nonassociative learning mechanisms, as well as a feedforward recurrent network for storing memory. Our circuit intuitively parallels biological neural architectures, and it can be readily generalized to other forms of cellular learning and extinction. The simulation of neural function with electronic device analogs may provide insight into biological processes such as decision making, learning, and adaptation, while facilitating advanced parallel information processing in hardware.

Analog Circuit Design Optimization Based on Evolutionary Algorithms

Directory of Open Access Journals (Sweden)

Mansour Barari

2014-01-01

Full Text Available This paper investigates an evolutionary-based designing system for automated sizing of analog integrated circuits (ICs. Two evolutionary algorithms, genetic algorithm and PSO (Parswal particle swarm optimization algorithm, are proposed to design analog ICs with practical user-defined specifications. On the basis of the combination of HSPICE and MATLAB, the system links circuit performances, evaluated through specific electrical simulation, to the optimization system in the MATLAB environment, for the selected topology. The system has been tested by typical and hard-to-design cases, such as complex analog blocks with stringent design requirements. The results show that the design specifications are closely met. Comparisons with available methods like genetic algorithms show that the proposed algorithm offers important advantages in terms of optimization quality and robustness. Moreover, the algorithm is shown to be efficient.

Digital redesign of anti-wind-up controller for cascaded analog system.

Science.gov (United States)

Chen, Y S; Tsai, J S H; Shieh, L S; Moussighi, M M

2003-01-01

The cascaded conventional anti-wind-up (CAW) design method for integral controller is discussed. Then, the prediction-based digital redesign methodology is utilized to find the new pulse amplitude modulated (PAM) digital controller for effective digital control of the analog plant with input saturation constraint. The desired digital controller is determined from existing or pre-designed CAW analog controller. The proposed method provides a novel methodology for indirect digital design of a continuous-time unity output-feedback system with a cascaded analog controller as in the case of PID controllers for industrial control processes with the presence of actuator saturations. It enables us to implement an existing or pre-designed cascaded CAW analog controller via a digital controller effectively.

Transistor analogs of emergent iono-neuronal dynamics.

Science.gov (United States)

Rachmuth, Guy; Poon, Chi-Sang

2008-06-01

Neuromorphic analog metal-oxide-silicon (MOS) transistor circuits promise compact, low-power, and high-speed emulations of iono-neuronal dynamics orders-of-magnitude faster than digital simulation. However, their inherently limited input voltage dynamic range vs power consumption and silicon die area tradeoffs makes them highly sensitive to transistor mismatch due to fabrication inaccuracy, device noise, and other nonidealities. This limitation precludes robust analog very-large-scale-integration (aVLSI) circuits implementation of emergent iono-neuronal dynamics computations beyond simple spiking with limited ion channel dynamics. Here we present versatile neuromorphic analog building-block circuits that afford near-maximum voltage dynamic range operating within the low-power MOS transistor weak-inversion regime which is ideal for aVLSI implementation or implantable biomimetic device applications. The fabricated microchip allowed robust realization of dynamic iono-neuronal computations such as coincidence detection of presynaptic spikes or pre- and postsynaptic activities. As a critical performance benchmark, the high-speed and highly interactive iono-neuronal simulation capability on-chip enabled our prompt discovery of a minimal model of chaotic pacemaker bursting, an emergent iono-neuronal behavior of fundamental biological significance which has hitherto defied experimental testing or computational exploration via conventional digital or analog simulations. These compact and power-efficient transistor analogs of emergent iono-neuronal dynamics open new avenues for next-generation neuromorphic, neuroprosthetic, and brain-machine interface applications.

Automatic activation of categorical and abstract analogical relations in analogical reasoning.

Science.gov (United States)

Green, Adam E; Fugelsang, Jonathan A; Dunbar, Kevin N

2006-10-01

We examined activation of concepts during analogical reasoning. Subjects made either analogical judgments or categorical judgments about four-word sets. After each four-word set, they named the ink color of a single word in a modified Stroop task. Words that referred to category relations were primed (as indicated by longer response times on Stroop color naming) subsequent to analogical judgments and categorical judgments. This finding suggests that activation of category concepts plays a fundamental role in analogical thinking. When colored words referred to analogical relations, priming occurred subsequent to analogical judgments, but not to categorical judgments, even though identical four-word stimuli were used for both types of judgments. This finding lends empirical support to the hypothesis that, when people comprehend the analogy between two items, they activate an abstract analogical relation that is distinct from the specific content items that compose the analogy.

Common and dissociable prefrontal loci associated with component mechanisms of analogical reasoning.

Science.gov (United States)

Cho, Soohyun; Moody, Teena D; Fernandino, Leonardo; Mumford, Jeanette A; Poldrack, Russell A; Cannon, Tyrone D; Knowlton, Barbara J; Holyoak, Keith J

2010-03-01

The ability to draw analogies requires 2 key cognitive processes, relational integration and resolution of interference. The present study aimed to identify the neural correlates of both component processes of analogical reasoning within a single, nonverbal analogy task using event-related functional magnetic resonance imaging. Participants verified whether a visual analogy was true by considering either 1 or 3 relational dimensions. On half of the trials, there was an additional need to resolve interference in order to make a correct judgment. Increase in the number of dimensions to integrate was associated with increased activation in the lateral prefrontal cortex as well as lateral frontal pole in both hemispheres. When there was a need to resolve interference during reasoning, activation increased in the lateral prefrontal cortex but not in the frontal pole. We identified regions in the middle and inferior frontal gyri which were exclusively sensitive to demands on each component process, in addition to a partial overlap between these neural correlates of each component process. These results indicate that analogical reasoning is mediated by the coordination of multiple regions of the prefrontal cortex, of which some are sensitive to demands on only one of these 2 component processes, whereas others are sensitive to both.

Analog computing

CERN Document Server

Ulmann, Bernd

2013-01-01

This book is a comprehensive introduction to analog computing. As most textbooks about this powerful computing paradigm date back to the 1960s and 1970s, it fills a void and forges a bridge from the early days of analog computing to future applications. The idea of analog computing is not new. In fact, this computing paradigm is nearly forgotten, although it offers a path to both high-speed and low-power computing, which are in even more demand now than they were back in the heyday of electronic analog computers.

Project for a codable central unit for analog data acquisition

International Nuclear Information System (INIS)

Bouras, F.; Da Costa Vieira, D.; Sohier, B.

1974-07-01

The instrumentation for a 256 channel codable central processor intended for an operation in connection with a computer is presented. The computer indicates the adresses of the channels to be measured, orders the conversion, and acquires the results of measurements. The acquisition and computer coupling unit is located in a standard rock CAMAC (6 U 19inch., 25 positions); an example of configuration is given. The measurement velocity depends on the converter speed and dead time of analog circuits; for a ADC 1103 converter the total dead time is 6.5s min. The analog circuits are intended for +-10V range, the accuracy is 1/2n (2n is the number of bits). The result is acquired in words of 12 bits maximum. The information transfer and analog commutation (through integrated analog gates) are discussed [fr

Analog integrated circuit design automation placement, routing and parasitic extraction techniques

CERN Document Server

Martins, Ricardo; Horta, Nuno

2017-01-01

This book introduces readers to a variety of tools for analog layout design automation. After discussing the placement and routing problem in electronic design automation (EDA), the authors overview a variety of automatic layout generation tools, as well as the most recent advances in analog layout-aware circuit sizing. The discussion includes different methods for automatic placement (a template-based Placer and an optimization-based Placer), a fully-automatic Router and an empirical-based Parasitic Extractor. The concepts and algorithms of all the modules are thoroughly described, enabling readers to reproduce the methodologies, improve the quality of their designs, or use them as starting point for a new tool. All the methods described are applied to practical examples for a 130nm design process, as well as placement and routing benchmark sets. Introduces readers to hierarchical combination of Pareto fronts of placements; Presents electromigration-aware routing with multilayer multiport terminal structures...

Science Teachers' Analogical Reasoning

Science.gov (United States)

Mozzer, Nilmara Braga; Justi, Rosária

2013-08-01

Analogies can play a relevant role in students' learning. However, for the effective use of analogies, teachers should not only have a well-prepared repertoire of validated analogies, which could serve as bridges between the students' prior knowledge and the scientific knowledge they desire them to understand, but also know how to introduce analogies in their lessons. Both aspects have been discussed in the literature in the last few decades. However, almost nothing is known about how teachers draw their own analogies for instructional purposes or, in other words, about how they reason analogically when planning and conducting teaching. This is the focus of this paper. Six secondary teachers were individually interviewed; the aim was to characterize how they perform each of the analogical reasoning subprocesses, as well as to identify their views on analogies and their use in science teaching. The results were analyzed by considering elements of both theories about analogical reasoning: the structural mapping proposed by Gentner and the analogical mechanism described by Vosniadou. A comprehensive discussion of our results makes it evident that teachers' content knowledge on scientific topics and on analogies as well as their pedagogical content knowledge on the use of analogies influence all their analogical reasoning subprocesses. Our results also point to the need for improving teachers' knowledge about analogies and their ability to perform analogical reasoning.

Digitally-assisted analog and RF CMOS circuit design for software-defined radio

CERN Document Server

Okada, Kenichi

2011-01-01

This book describes the state-of-the-art in RF, analog, and mixed-signal circuit design for Software Defined Radio (SDR). It synthesizes for analog/RF circuit designers the most important general design approaches to take advantage of the most recent CMOS technology, which can integrate millions of transistors, as well as several real examples from the most recent research results.

Analog IC Design at the University of Twente

NARCIS (Netherlands)

Nauta, Bram

2007-01-01

This article describes some recent research results from the IC Design group of the University of Twente, located in Enschede, The Netherlands. Our research focuses on analog CMOS circuit design with emphasis on high frequency and broadband circuits. With the trend of system integration in mind, we

Analog synthetic biology.

Science.gov (United States)

Sarpeshkar, R

2014-03-28

We analyse the pros and cons of analog versus digital computation in living cells. Our analysis is based on fundamental laws of noise in gene and protein expression, which set limits on the energy, time, space, molecular count and part-count resources needed to compute at a given level of precision. We conclude that analog computation is significantly more efficient in its use of resources than deterministic digital computation even at relatively high levels of precision in the cell. Based on this analysis, we conclude that synthetic biology must use analog, collective analog, probabilistic and hybrid analog-digital computational approaches; otherwise, even relatively simple synthetic computations in cells such as addition will exceed energy and molecular-count budgets. We present schematics for efficiently representing analog DNA-protein computation in cells. Analog electronic flow in subthreshold transistors and analog molecular flux in chemical reactions obey Boltzmann exponential laws of thermodynamics and are described by astoundingly similar logarithmic electrochemical potentials. Therefore, cytomorphic circuits can help to map circuit designs between electronic and biochemical domains. We review recent work that uses positive-feedback linearization circuits to architect wide-dynamic-range logarithmic analog computation in Escherichia coli using three transcription factors, nearly two orders of magnitude more efficient in parts than prior digital implementations.

VHDL Implementation of Sigma-Delta Analog To Digital Converter

Science.gov (United States)

Chavan, R. N.; Chougule, D. G.

2010-11-01

Sigma-Delta modulation techniques provide a range of opportunities in a signal processing system for both increasing performance and data path optimization along the silicon area axis in the design space. One of the most challenging tasks in Analog to Digital Converter (ADC) design is to adapt the circuitry to ever new CMOS process technology. For digital circuits the number of gates per square mm app. doubles per chip generation. Integration of analog parts in newer deep submicron technologies is much more tough and additionally complicated because the usable voltage ranges are decreasing with every new integration step. This paper shows an approach which only uses 2 resistors and 1 capacitor which are located outside a pure digital chip. So all integration advantages of pure digital chips are preserved, there is no design effort for a new chip generation and the ADC also can be used for FPGAs. Resolutions of up to 16 bit are achievable. Sample rates in the 1 MHz region are feasible so that the approach is also useful for ADCs for xDSL technologies.

SEMICONDUCTOR INTEGRATED CIRCUITS: A reconfigurable analog baseband circuit for WLAN, WCDMA, and Bluetooth

Science.gov (United States)

Tao, Tong; Baoyong, Chi; Ziqiang, Wang; Ying, Zhang; Hanjun, Jiang; Zhihua, Wang

2010-05-01

A reconfigurable analog baseband circuit for WLAN, WCDMA, and Bluetooth in 0.35 μm CMOS is presented. The circuit consists of two variable gain amplifiers (VGA) in cascade and a Gm-C elliptic low-pass filter (LPF). The filter-order and the cut-off frequency of the LPF can be reconfigured to satisfy the requirements of various applications. In order to achieve the optimum power consumption, the bandwidth of the VGAs can also be dynamically reconfigured and some Gm cells can be cut off in the given application. Simulation results show that the analog baseband circuit consumes 16.8 mW for WLAN, 8.9 mW for WCDMA and only 6.5 mW for Bluetooth, all with a 3 V power supply. The analog baseband circuit could provide -10 to +40 dB variable gain, third-order low pass filtering with 1 MHz cut-off frequency for Bluetooth, fourth-order low pass filtering with 2.2 MHz cut-off frequency for WCDMA, and fifth-order low pass filtering with 11 MHz cut-off frequency for WLAN, respectively.

Configurable Analog-Digital Conversion Using the Neural EngineeringFramework

Directory of Open Access Journals (Sweden)

Christian G Mayr

2014-07-01

Full Text Available Efficient Analog-Digital Converters (ADC are one of the mainstays of mixed-signal integrated circuit design. Besides the conventional ADCs used in mainstream ICs, there have been various attempts in the past to utilize neuromorphic networks to accomplish an efficient crossing between analog and digital domains, i.e. to build neurally inspired ADCs. Generally, these have suffered from the same problems as conventional ADCs, that is they require high-precision, handcrafted analog circuits and are thus not technology portable. In this paper, we present an ADC based on the Neural Engineering Framework (NEF. It carries out a large fraction of the overall ADC process in the digital domain, i.e. it is easily portable across technologies. The analog-digital conversion takes full advantage of the high degree of parallelism inherent in neuromorphic networks, making for a very scalable ADC. In addition, it has a number of features not commonly found in conventional ADCs, such as a runtime reconfigurability of the ADC sampling rate, resolution and transfer characteristic.

A PURE NODAL-ANALYSIS METHOD SUITABLE FOR ANALOG CIRCUITS USING NULLORS

OpenAIRE

E. Tlelo-Cuautle; L.A. Sarmiento-Reyes

2003-01-01

A novel technique suitable for computer-aided analysis of analog integrated circuits (ICs) is introduced. This technique uses the features of both nodal-analysis (NA) and symbolic analysis, at nullor level. First, the nullor is used to model the ideal behavior of several analog devices, namely: transistors, opamps, OTAs, and current conveyors. From this modeling approach, it is shown how to transform circuits working in voltage-mode to current-mode and vice-versa. Second, it is demonstrated t...

Rhetoric and analogies

OpenAIRE

Aragonès, Enriqueta; Gilboa, Itzhak; Postlewaite, Andrew; Schmeidler, David; Universitat Autònoma de Barcelona. Unitat de Fonaments de l'Anàlisi Econòmica; Universitat Autònoma de Barcelona. Institut d'Anàlisi Econòmica

2013-01-01

The art of rhetoric may be defined as changing other people's minds (opinions, beliefs) without providing them new information. One tech- nique heavily used by rhetoric employs analogies. Using analogies, one may draw the listener's attention to similarities between cases and to re-organize existing information in a way that highlights certain reg- ularities. In this paper we offer two models of analogies, discuss their theoretical equivalence, and show that finding good analogies is a com- p...

Difference potentials analogous to Cauchy integrals

International Nuclear Information System (INIS)

Ryaben'kii, Viktor S

2012-01-01

This work presents the state of the art in the theory of potentials for the solutions of systems of linear difference equations, which was proposed by the author in 1969. The role played by difference potentials in the solution of linear difference schemes of general form is for the first time compared in detail to the role played by Cauchy-type integrals in the theory of analytic functions. New vistas are exposed, which are opened up by the theory of difference potentials and arise through combining the universality and algorithmicity of difference schemes with certain properties of Cauchy-type integrals. A brief bibliographical review covers some of the fundamental applications of the theory which have already been implemented. Bibliography: 61 titles.

Intuitive analog circuit design

CERN Document Server

Thompson, Marc

2013-01-01

Intuitive Analog Circuit Design outlines ways of thinking about analog circuits and systems that let you develop a feel for what a good, working analog circuit design should be. This book reflects author Marc Thompson's 30 years of experience designing analog and power electronics circuits and teaching graduate-level analog circuit design, and is the ideal reference for anyone who needs a straightforward introduction to the subject. In this book, Dr. Thompson describes intuitive and ""back-of-the-envelope"" techniques for designing and analyzing analog circuits, including transistor amplifi

Development of analog watch with minute repeater

Science.gov (United States)

Okigami, Tomio; Aoyama, Shigeru; Osa, Takashi; Igarashi, Kiyotaka; Ikegami, Tomomi

A complementary metal oxide semiconductor with large scale integration was developed for an electronic minute repeater. It is equipped with the synthetic struck sound circuit to generate natural struck sound necessary for the minute repeater. This circuit consists of an envelope curve drawing circuit, frequency mixer, polyphonic mixer, and booster circuit made by using analog circuit technology. This large scale integration is a single chip microcomputer with motor drivers and input ports in addition to the synthetic struck sound circuit, and it is possible to make an electronic system of minute repeater at a very low cost in comparison with the conventional type.

Structure problems in the analog computation; Problemes de structure dans le calcul analogique

Energy Technology Data Exchange (ETDEWEB)

Braffort, P.L. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1957-07-01

The recent mathematical development showed the importance of elementary structures (algebraic, topological, etc.) in abeyance under the great domains of classical analysis. Such structures in analog computation are put in evidence and possible development of applied mathematics are discussed. It also studied the topological structures of the standard representation of analog schemes such as additional triangles, integrators, phase inverters and functions generators. The analog method gives only the function of the variable: time, as results of its computations. But the course of computation, for systems including reactive circuits, introduces order structures which are called 'chronological'. Finally, it showed that the approximation methods of ordinary numerical and digital computation present the same structure as these analog computation. The structure analysis permits fruitful comparisons between the several domains of applied mathematics and suggests new important domains of application for analog method. (M.P.)

Structure problems in the analog computation; Problemes de structure dans le calcul analogique

Energy Technology Data Exchange (ETDEWEB)

Braffort, P L [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1957-07-01

The recent mathematical development showed the importance of elementary structures (algebraic, topological, etc.) in abeyance under the great domains of classical analysis. Such structures in analog computation are put in evidence and possible development of applied mathematics are discussed. It also studied the topological structures of the standard representation of analog schemes such as additional triangles, integrators, phase inverters and functions generators. The analog method gives only the function of the variable: time, as results of its computations. But the course of computation, for systems including reactive circuits, introduces order structures which are called 'chronological'. Finally, it showed that the approximation methods of ordinary numerical and digital computation present the same structure as these analog computation. The structure analysis permits fruitful comparisons between the several domains of applied mathematics and suggests new important domains of application for analog method. (M.P.)

Measurement and Analysis of Multiple Output Transient Propagation in BJT Analog Circuits

Science.gov (United States)

Roche, Nicolas J.-H.; Khachatrian, A.; Warner, J. H.; Buchner, S. P.; McMorrow, D.; Clymer, D. A.

2016-08-01

The propagation of Analog Single Event Transients (ASETs) to multiple outputs of Bipolar Junction Transistor (BJTs) Integrated Circuits (ICs) is reported for the first time. The results demonstrate that ASETs can appear at several outputs of a BJT amplifier or comparator as a result of a single ion or single laser pulse strike at a single physical location on the chip of a large-scale integrated BJT analog circuit. This is independent of interconnect cross-talk or charge-sharing effects. Laser experiments, together with SPICE simulations and analysis of the ASET's propagation in the s-domain are used to explain how multiple-output transients (MOTs) are generated and propagate in the device. This study demonstrates that both the charge collection associated with an ASET and the ASET's shape, commonly used to characterize the propagation of SETs in devices and systems, are unable to explain quantitatively how MOTs propagate through an integrated analog circuit. The analysis methodology adopted here involves combining the Fourier transform of the propagating signal and the current-source transfer function in the s-domain. This approach reveals the mechanisms involved in the transient signal propagation from its point of generation to one or more outputs without the signal following a continuous interconnect path.

Synthetic analog computation in living cells.

Science.gov (United States)

Daniel, Ramiz; Rubens, Jacob R; Sarpeshkar, Rahul; Lu, Timothy K

2013-05-30

A central goal of synthetic biology is to achieve multi-signal integration and processing in living cells for diagnostic, therapeutic and biotechnology applications. Digital logic has been used to build small-scale circuits, but other frameworks may be needed for efficient computation in the resource-limited environments of cells. Here we demonstrate that synthetic analog gene circuits can be engineered to execute sophisticated computational functions in living cells using just three transcription factors. Such synthetic analog gene circuits exploit feedback to implement logarithmically linear sensing, addition, ratiometric and power-law computations. The circuits exhibit Weber's law behaviour as in natural biological systems, operate over a wide dynamic range of up to four orders of magnitude and can be designed to have tunable transfer functions. Our circuits can be composed to implement higher-order functions that are well described by both intricate biochemical models and simple mathematical functions. By exploiting analog building-block functions that are already naturally present in cells, this approach efficiently implements arithmetic operations and complex functions in the logarithmic domain. Such circuits may lead to new applications for synthetic biology and biotechnology that require complex computations with limited parts, need wide-dynamic-range biosensing or would benefit from the fine control of gene expression.

Hardware Evolution of Analog Speed Controllers for a DC Motor

Science.gov (United States)

Gwaltney, David A.; Ferguson, Michael I.

2003-01-01

This viewgraph presentation provides information on the design of analog speed controllers for DC motors on aerospace systems. The presentation includes an overview of controller evolution, evolvable controller configuration, an emphasis on proportion integral (PI) controllers, schematic diagrams, and experimental results.

Education and Public Outreach and Engagement at NASA's Analog Missions in 2012

Science.gov (United States)

Watkins, Wendy L.; Janoiko, Barbara A.; Mahoney, Erin; Hermann, Nicole B.

2013-01-01

Analog missions are integrated, multi-disciplinary activities that test key features of future human space exploration missions in an integrated fashion to gain a deeper understanding of system-level interactions and operations early in conceptual development. These tests often are conducted in remote and extreme environments that are representative in one or more ways to that of future spaceflight destinations. They may also be conducted at NASA facilities, using advanced modeling and human-in-the-loop scenarios. As NASA develops a capability driven framework to transport crew to a variety of space environments, it will use analog missions to gather requirements and develop the technologies necessary to ensure successful exploration beyond low Earth orbit. NASA s Advanced Exploration Systems (AES) Division conducts these high-fidelity integrated tests, including the coordination and execution of a robust education and public outreach (EPO) and engagement program for each mission. Conducting these mission scenarios in unique environments not only provides an opportunity to test the EPO concepts for the particular future-mission scenario, such as the best methods for conducting events with a communication time delay, but it also provides an avenue to deliver NASA s human space exploration key messages. These analogs are extremely exciting to students and the public, and they are performed in such a way that the public can feel like part of the mission. They also provide an opportunity for crew members to obtain training in education and public outreach activities similar to what they would perform in space. The analog EPO team is responsible for the coordination and execution of the events, the overall social media component for each mission, and public affairs events such as media visits and interviews. They also create new and exciting ways to engage the public, manage and create website content, coordinate video footage for missions, and coordinate and integrate

High-speed and high-resolution analog-to-digital and digital-to-analog converters

NARCIS (Netherlands)

van de Plassche, R.J.

1989-01-01

Analog-to-digital and digital-to-analog converters are important building blocks connecting the analog world of transducers with the digital world of computing, signal processing and data acquisition systems. In chapter two the converter as part of a system is described. Requirements of analog

Analog integrated circuit for micro-gyro interface realized by multi-chip service in Japan; Multi chip service ni yoru micro gyro interface shuseki kairo no sekkei to shisaku

Energy Technology Data Exchange (ETDEWEB)

Maenaka, K.; Fujita, T.; Okamoto, K.; Maeda, M. [Himeji Institute of Technology, Hyogo (Japan)

1998-10-01

This paper deals with an analog integrated circuit for micro-machined gyroscopes with capacitive output. The Integrated circuit was fabricated as a part of the first project from the `Micromachining Multi-Chip Service Cooperative Re-search Committee` organized by The Institute of Electrical Engineers Japan. This multi-chip service project offers a master slice chip with an equivalent of 9 blocks of operational amplifier circuits. Our integrated circuit includes a modulator, demodulator and synchronous rectifier for detecting small changes in the capacitance of a silicon gyroscope. In the paper, the experimental results of fabricated samples will be described. 13 refs., 15 figs.

Morphometry of Left Frontal and Temporal Poles Predicts Analogical Reasoning Abilities.

Science.gov (United States)

Aichelburg, Clarisse; Urbanski, Marika; Thiebaut de Schotten, Michel; Humbert, Frederic; Levy, Richard; Volle, Emmanuelle

2016-03-01

Analogical reasoning is critical for making inferences and adapting to novelty. It can be studied experimentally using tasks that require creating similarities between situations or concepts, i.e., when their constituent elements share a similar organization or structure. Brain correlates of analogical reasoning have mostly been explored using functional imaging that has highlighted the involvement of the left rostrolateral prefrontal cortex (rlPFC) in healthy subjects. However, whether inter-individual variability in analogical reasoning ability in a healthy adult population is related to differences in brain architecture is unknown. We investigated this question by employing linear regression models of performance in analogy tasks and voxel-based morphometry in 54 healthy subjects. Our results revealed that the ability to reason by analogy was associated with structural variability in the left rlPFC and the anterior part of the inferolateral temporal cortex. Tractography of diffusion-weighted images suggested that these 2 regions have a different set of connections but may exchange information via the arcuate fasciculus. These results suggest that enhanced integrative and semantic abilities supported by structural variation in these areas (or their connectivity) may lead to more efficient analogical reasoning. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Two high accuracy digital integrators for Rogowski current transducers

Science.gov (United States)

Luo, Pan-dian; Li, Hong-bin; Li, Zhen-hua

2014-01-01

The Rogowski current transducers have been widely used in AC current measurement, but their accuracy is mainly subject to the analog integrators, which have typical problems such as poor long-term stability and being susceptible to environmental conditions. The digital integrators can be another choice, but they cannot obtain a stable and accurate output for the reason that the DC component in original signal can be accumulated, which will lead to output DC drift. Unknown initial conditions can also result in integral output DC offset. This paper proposes two improved digital integrators used in Rogowski current transducers instead of traditional analog integrators for high measuring accuracy. A proportional-integral-derivative (PID) feedback controller and an attenuation coefficient have been applied in improving the Al-Alaoui integrator to change its DC response and get an ideal frequency response. For the special design in the field of digital signal processing, the improved digital integrators have better performance than analog integrators. Simulation models are built for the purpose of verification and comparison. The experiments prove that the designed integrators can achieve higher accuracy than analog integrators in steady-state response, transient-state response, and temperature changing condition.

Structured Analog CMOS Design

CERN Document Server

Stefanovic, Danica

2008-01-01

Structured Analog CMOS Design describes a structured analog design approach that makes it possible to simplify complex analog design problems and develop a design strategy that can be used for the design of large number of analog cells. It intentionally avoids treating the analog design as a mathematical problem, developing a design procedure based on the understanding of device physics and approximations that give insight into parameter interdependences. The proposed transistor-level design procedure is based on the EKV modeling approach and relies on the device inversion level as a fundament

Analog and hybrid computing

CERN Document Server

Hyndman, D E

2013-01-01

Analog and Hybrid Computing focuses on the operations of analog and hybrid computers. The book first outlines the history of computing devices that influenced the creation of analog and digital computers. The types of problems to be solved on computers, computing systems, and digital computers are discussed. The text looks at the theory and operation of electronic analog computers, including linear and non-linear computing units and use of analog computers as operational amplifiers. The monograph examines the preparation of problems to be deciphered on computers. Flow diagrams, methods of ampl

Individual behavioral phenotypes: an integrative meta-theoretical framework. Why "behavioral syndromes" are not analogs of "personality".

Science.gov (United States)

Uher, Jana

2011-09-01

Animal researchers are increasingly interested in individual differences in behavior. Their interpretation as meaningful differences in behavioral strategies stable over time and across contexts, adaptive, heritable, and acted upon by natural selection has triggered new theoretical developments. However, the analytical approaches used to explore behavioral data still address population-level phenomena, and statistical methods suitable to analyze individual behavior are rarely applied. I discuss fundamental investigative principles and analytical approaches to explore whether, in what ways, and under which conditions individual behavioral differences are actually meaningful. I elaborate the meta-theoretical ideas underlying common theoretical concepts and integrate them into an overarching meta-theoretical and methodological framework. This unravels commonalities and differences, and shows that assumptions of analogy to concepts of human personality are not always warranted and that some theoretical developments may be based on methodological artifacts. Yet, my results also highlight possible directions for new theoretical developments in animal behavior research. Copyright © 2011 Wiley Periodicals, Inc.

Analog-to-digital conversion

CERN Document Server

Pelgrom, Marcel J M

2010-01-01

The design of an analog-to-digital converter or digital-to-analog converter is one of the most fascinating tasks in micro-electronics. In a converter the analog world with all its intricacies meets the realm of the formal digital abstraction. Both disciplines must be understood for an optimum conversion solution. In a converter also system challenges meet technology opportunities. Modern systems rely on analog-to-digital converters as an essential part of the complex chain to access the physical world. And processors need the ultimate performance of digital-to-analog converters to present the results of their complex algorithms. The same progress in CMOS technology that enables these VLSI digital systems creates new challenges for analog-to-digital converters: lower signal swings, less power and variability issues. Last but not least, the analog-to-digital converter must follow the cost reduction trend. These changing boundary conditions require micro-electronics engineers to consider their design choices for...

Context, cortex, and associations: a connectionist developmental approach to verbal analogies

Science.gov (United States)

Kollias, Pavlos; McClelland, James L.

2013-01-01

We present a PDP model of binary choice verbal analogy problems (A:B as C:[D1|D2], where D1 and D2 represent choice alternatives). We train a recurrent neural network in item-relation-item triples and use this network to test performance on analogy questions. Without training on analogy problems per se, the model explains the developmental shift from associative to relational responding as an emergent consequence of learning upon the environment's statistics. Such learning allows gradual, item-specific acquisition of relational knowledge to overcome the influence of unbalanced association frequency, accounting for association effects of analogical reasoning seen in cognitive development. The network also captures the overall degradation in performance after anterior temporal damage by deleting a fraction of learned connections, while capturing the return of associative dominance after frontal damage by treating frontal structures as necessary for maintaining activation of A and B while seeking a relation between C and D. While our theory is still far from being complete it provides a unified explanation of findings that need to be considered together in any integrated account of analogical reasoning. PMID:24312068

Context, cortex, and associations: a connectionist developmental approach to verbal analogies

Directory of Open Access Journals (Sweden)

Pavlos eKollias

2013-11-01

Full Text Available We present a PDP model of binary choice verbal analogy problems (A:B as C:[D1|D2], where D1 and D2 represent choice alternatives. We train a recurrent neural network in item-relation- item triples and use this network to test performance on analogy questions. Without training on analogy problems per se, the model explains the developmental shift from associative to relational responding as an emergent consequence of learning upon the environment’s statistics. Such learning allows gradual, item-specific acquisition of relational knowledge to overcome the influence of unbalanced association frequency, accounting for association effects of analogical reasoning seen in cognitive development. The network also captures the overall degradation in performance after anterior temporal damage by deleting a fraction of learned connections, while capturing the return of associative dominance after frontal damage by treating frontal structures as necessary for maintaining activation of A and B while seeking a relation between C and D. While our theory is still far from being complete it provides a unified explanation of findings that need to be considered together in any integrated account of analogical reasoning.

Context, cortex, and associations: a connectionist developmental approach to verbal analogies.

Science.gov (United States)

Kollias, Pavlos; McClelland, James L

2013-01-01

We present a PDP model of binary choice verbal analogy problems (A:B as C:[D1|D2], where D1 and D2 represent choice alternatives). We train a recurrent neural network in item-relation-item triples and use this network to test performance on analogy questions. Without training on analogy problems per se, the model explains the developmental shift from associative to relational responding as an emergent consequence of learning upon the environment's statistics. Such learning allows gradual, item-specific acquisition of relational knowledge to overcome the influence of unbalanced association frequency, accounting for association effects of analogical reasoning seen in cognitive development. The network also captures the overall degradation in performance after anterior temporal damage by deleting a fraction of learned connections, while capturing the return of associative dominance after frontal damage by treating frontal structures as necessary for maintaining activation of A and B while seeking a relation between C and D. While our theory is still far from being complete it provides a unified explanation of findings that need to be considered together in any integrated account of analogical reasoning.

Activity ranking of synthetic analogs targeting vascular endothelial growth factor receptor 2 by an integrated cell membrane chromatography system.

Science.gov (United States)

Wang, Dongyao; Lv, Diya; Chen, Xiaofei; Liu, Yue; Ding, Xuan; Jia, Dan; Chen, Langdong; Zhu, Zhenyu; Cao, Yan; Chai, Yifeng

2015-12-01

Evaluating the biological activities of small molecules represents an important part of the drug discovery process. Cell membrane chromatography (CMC) is a well-developed biological chromatographic technique. In this study, we have developed combined SMMC-7721/CMC and HepG2/CMC with high-performance liquid chromatography and time-of-flight mass spectrometry to establish an integrated screening platform. These systems was subsequently validated and used for evaluating the activity of quinazoline compounds, which were designed and synthesized to target vascular endothelial growth factor receptor 2. The inhibitory activities of these compounds towards this receptor were also tested using a classical caliper mobility shift assay. The results revealed a significant correlation between these two methods (R(2) = 0.9565 or 0.9420) for evaluating the activities of these compounds. Compared with traditional methods of evaluating the activities analogous compounds, this integrated cell membrane chromatography screening system took less time and was more cost effective, indicating that it could be used as a practical method in drug discovery. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Repository-analog experiments of nuclear waste leaching and migration

International Nuclear Information System (INIS)

Seitz, M.G.

1982-01-01

The potential for radionuclide migration from a breached nuclear-waste repository depends on the leaching and subsequent interaction of the leached radionuclides with materials in the groundwater flow path. An attempt is made to consider all interactions using experiments that integrate repository materials. Results of a repository-analog experiment using borosilicate glass, fissured granite, and flowing water suggest: (1) plutonium was immobile possibly because of its low solubility; (2) caesium migrated down slowly because of sorption; and (3) neptunium remained oxidized even in water of low oxidation potential. By summing the effects of all interactions, not just sorption, the repository-analog experiment produced radionuclide migration that could be expected from a breached repository. (author)

Analog earthquakes

International Nuclear Information System (INIS)

Hofmann, R.B.

1995-01-01

Analogs are used to understand complex or poorly understood phenomena for which little data may be available at the actual repository site. Earthquakes are complex phenomena, and they can have a large number of effects on the natural system, as well as on engineered structures. Instrumental data close to the source of large earthquakes are rarely obtained. The rare events for which measurements are available may be used, with modfications, as analogs for potential large earthquakes at sites where no earthquake data are available. In the following, several examples of nuclear reactor and liquified natural gas facility siting are discussed. A potential use of analog earthquakes is proposed for a high-level nuclear waste (HLW) repository

Property-Based Monitoring of Analog and Mixed-Signal Systems

Science.gov (United States)

Havlicek, John; Little, Scott; Maler, Oded; Nickovic, Dejan

In the recent past, there has been a steady growth of the market for consumer embedded devices such as cell phones, GPS and portable multimedia systems. In embedded systems, digital, analog and software components are combined on a single chip, resulting in increasingly complex designs that introduce richer functionality on smaller devices. As a consequence, the potential insertion of errors into a design becomes higher, yielding an increasing need for automated analog and mixed-signal validation tools. In the purely digital setting, formal verification based on properties expressed in industrial specification languages such as PSL and SVA is nowadays successfully integrated in the design flow. On the other hand, the validation of analog and mixed-signal systems still largely depends on simulation-based, ad-hoc methods. In this tutorial, we consider some ingredients of the standard verification methodology that can be successfully exported from digital to analog and mixed-signal setting, in particular property-based monitoring techniques. Property-based monitoring is a lighter approach to the formal verification, where the system is seen as a "black-box" that generates sets of traces, whose correctness is checked against a property, that is its high-level specification. Although incomplete, monitoring is effectively used to catch faults in systems, without guaranteeing their full correctness.

Analog circuit design

CERN Document Server

Dobkin, Bob

2012-01-01

Analog circuit and system design today is more essential than ever before. With the growth of digital systems, wireless communications, complex industrial and automotive systems, designers are being challenged to develop sophisticated analog solutions. This comprehensive source book of circuit design solutions aids engineers with elegant and practical design techniques that focus on common analog challenges. The book's in-depth application examples provide insight into circuit design and application solutions that you can apply in today's demanding designs. <

Modern analog filter analysis and design a practical approach

CERN Document Server

Raut, R

2011-01-01

Starting from the fundamentals, the present book describes methods of designing analog electronic filters and illustrates these methods by providing numerical and circuit simulation programs. The subject matters comprise many concepts and techniques that are not available in other text books on the market. To name a few - principle of transposition and its application in directly realizing current mode filters from well known voltage mode filters; an insight into the technological aspect of integrated circuit components used to implement an integrated circuit filter; a careful blending of basi

Design and implementation of a reconfigurable mixed-signal SoC based on field programmable analog arrays

Science.gov (United States)

Liu, Lintao; Gao, Yuhan; Deng, Jun

2017-11-01

This work presents a reconfigurable mixed-signal system-on-chip (SoC), which integrates switched-capacitor-based field programmable analog arrays (FPAA), analog-to-digital converter (ADC), digital-to-analog converter, digital down converter , digital up converter, 32-bit reduced instruction-set computer central processing unit (CPU) and other digital IPs on a single chip with 0.18 μm CMOS technology. The FPAA intellectual property could be reconfigured as different function circuits, such as gain amplifier, divider, sine generator, and so on. This single-chip integrated mixed-signal system is a complete modern signal processing system, occupying a die area of 7 × 8 mm 2 and consuming 719 mW with a clock frequency of 150 MHz for CPU and 200 MHz for ADC/DAC. This SoC chip can help customers to shorten design cycles, save board area, reduce the system power consumption and depress the system integration risk, which would afford a big prospect of application for wireless communication. Project supported by the National High Technology and Development Program of China (No. 2012AA012303).

Optical analogy. Synthesis report

International Nuclear Information System (INIS)

1965-01-01

The authors report the study of conditions under which light attenuation (reflection, diffusion, absorption) and the attenuation of some radiations (notably thermal neutrons) can be described with analogical calculations. The analogy between light physical properties and neutron properties is not searched for, but the analogy between their attenuation characteristics. After having discussed this possible analogy, they propose a mathematical formulation of neutron and optical phenomena which could theoretically justify the optical analogy. The second part reports a more practical study of optics problems such as the study of simple optics materials and illumination measurements, or more precisely the study of angular distributions of optical reflections, a determination of such angular distributions, and an experimental determination of the albedo

Are all analogies created equal? Prefrontal cortical functioning may predict types of analogical reasoning.

Science.gov (United States)

Chrysikou, Evangelia G; Thompson-Schill, Sharon L

2010-06-01

Abstract The proposed theory can account for analogies based on learned relationships between elements in the source and target domains. However, its explanatory power regarding the discovery of new relationships during analogical reasoning is limited. We offer an alternative perspective for the role of PFC in analogical thought that may better address different types of analogical mappings.

An Open-Source Tool Set Enabling Analog-Digital-Software Co-Design

Directory of Open Access Journals (Sweden)

Michelle Collins

2016-02-01

Full Text Available This paper presents an analog-digital hardware-software co-design environment for simulating and programming reconfigurable systems. The tool simulates, designs, as well as enables experimental measurements after compiling to configurable systems in the same integrated design tool framework. High level software in Scilab/Xcos (open-source programs similar to MATLAB/Simulink that converts the high-level block description by the user to blif format (sci2blif, which acts as an input to the modified VPR tool, including the code v p r 2 s w c s , encoding the specific platform through specific architecture files, resulting in a targetable switch list on the resulting configurable analog–digital system. The resulting tool uses an analog and mixed-signal library of components, enabling users and future researchers access to the basic analog operations/computations that are possible.

Children's Failure in Analogical Reasoning Tasks: A Problem of Focus of Attention and Information Integration?

Science.gov (United States)

Glady, Yannick; French, Robert M; Thibaut, Jean-Pierre

2017-01-01

Children's improved performance with age in analogy tasks has been explained by an increase in semantic knowledge of the items and the relations between them or by the development of an increased ability to inhibit irrelevant information. We tested the so-called "unbalanced attentional focus hypothesis" that claims that a failure to choose the "analogical" match can be the result of a difficulty to focus on all the relevant information available. Previous eye-tracking research has suggested, in analogies of the A:B::C:D format, that 5-6 year-olds organize their search around the C item. They focused significantly less than adults on the A:B pair, thereby hindering their discovering the relation(s) between A and B. We hypothesized that inducing them to focus their attention on the A:B pair at the beginning of the trial would affect their performance. In Experiment 1, increasing children's focus on the A:B pair did, indeed, lead to better performance. In contrast, in Experiment 2, focusing their attention on the A:B pair impaired performance when the most salient relation holding between A and B was, in fact, irrelevant for the analogy. By contrast, the obvious-but-irrelevant relation in the A:B pair had no negative effect on performance when no explicit A:B focusing was induced. These results are discussed in terms of the temporal organization of the task and availability of information, and of children's difficulties to disengage from the main goal of the task, when necessary.

Inferring principles for sustainable development of business through analogies from ecological systems

Directory of Open Access Journals (Sweden)

K. Sriram

2013-03-01

Full Text Available The literature in the field of sustainable development (SD of businesses is piecemeal and diverse. This paper identifies and integrates principles that businesses could use for transformation towards SD. This is done through analogical reasoning from the source context of ecological systems to the target contexts of business socio-economic systems and machine/technology systems. The methodologies of systems thinking and morphological analysis supplement the analogical reasoning. Based on this, twelve principles for sustainable development of business are inferred for business managers and policy makers.

Troubleshooting analog circuits

CERN Document Server

Pease, Robert A

1991-01-01

Troubleshooting Analog Circuits is a guidebook for solving product or process related problems in analog circuits. The book also provides advice in selecting equipment, preventing problems, and general tips. The coverage of the book includes the philosophy of troubleshooting; the modes of failure of various components; and preventive measures. The text also deals with the active components of analog circuits, including diodes and rectifiers, optically coupled devices, solar cells, and batteries. The book will be of great use to both students and practitioners of electronics engineering. Other

Reasoning by analogy requires the left frontal pole: lesion-deficit mapping and clinical implications.

Science.gov (United States)

Urbanski, Marika; Bréchemier, Marie-Laure; Garcin, Béatrice; Bendetowicz, David; Thiebaut de Schotten, Michel; Foulon, Chris; Rosso, Charlotte; Clarençon, Frédéric; Dupont, Sophie; Pradat-Diehl, Pascale; Labeyrie, Marc-Antoine; Levy, Richard; Volle, Emmanuelle

2016-06-01

SEE BURGESS DOI101093/BRAIN/AWW092 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE  : Analogical reasoning is at the core of the generalization and abstraction processes that enable concept formation and creativity. The impact of neurological diseases on analogical reasoning is poorly known, despite its importance in everyday life and in society. Neuroimaging studies of healthy subjects and the few studies that have been performed on patients have highlighted the importance of the prefrontal cortex in analogical reasoning. However, the critical cerebral bases for analogical reasoning deficits remain elusive. In the current study, we examined analogical reasoning abilities in 27 patients with focal damage in the frontal lobes and performed voxel-based lesion-behaviour mapping and tractography analyses to investigate the structures critical for analogical reasoning. The findings revealed that damage to the left rostrolateral prefrontal region (or some of its long-range connections) specifically impaired the ability to reason by analogies. A short version of the analogy task predicted the existence of a left rostrolateral prefrontal lesion with good accuracy. Experimental manipulations of the analogy tasks suggested that this region plays a role in relational matching or integration. The current lesion approach demonstrated that the left rostrolateral prefrontal region is a critical node in the analogy network. Our results also suggested that analogy tasks should be translated to clinical practice to refine the neuropsychological assessment of patients with frontal lobe lesions. © The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Analogical Reasoning in Geometry Education

Science.gov (United States)

Magdas, Ioana

2015-01-01

The analogical reasoning isn't used only in mathematics but also in everyday life. In this article we approach the analogical reasoning in Geometry Education. The novelty of this article is a classification of geometrical analogies by reasoning type and their exemplification. Our classification includes: analogies for understanding and setting a…

Wideband LTE power amplifier with integrated novel analog pre-distorter linearizer for mobile wireless communications.

Directory of Open Access Journals (Sweden)

Eswaran Uthirajoo

Full Text Available For the first time, a new circuit to extend the linear operation bandwidth of a LTE (Long Term Evolution power amplifier, while delivering a high efficiency is implemented in less than 1 mm2 chip area. The 950 µm × 900 µm monolithic microwave integrated circuit (MMIC power amplifier (PA is fabricated in a 2 µm InGaP/GaAs process. An on-chip analog pre-distorter (APD is designed to improve the linearity of the PA, up to 20 MHz channel bandwidth. Intended for 1.95 GHz Band 1 LTE application, the PA satisfies adjacent channel leakage ratio (ACLR and error vector magnitude (EVM specifications for a wide LTE channel bandwidth of 20 MHz at a linear output power of 28 dBm with corresponding power added efficiency (PAE of 52.3%. With a respective input and output return loss of 30 dB and 14 dB, the PA's power gain is measured to be 32.5 dB while exhibiting an unconditional stability characteristic from DC up to 5 GHz. The proposed APD technique serves to be a good solution to improve linearity of a PA without sacrificing other critical performance metrics.

Wideband LTE power amplifier with integrated novel analog pre-distorter linearizer for mobile wireless communications.

Science.gov (United States)

Uthirajoo, Eswaran; Ramiah, Harikrishnan; Kanesan, Jeevan; Reza, Ahmed Wasif

2014-01-01

For the first time, a new circuit to extend the linear operation bandwidth of a LTE (Long Term Evolution) power amplifier, while delivering a high efficiency is implemented in less than 1 mm2 chip area. The 950 µm × 900 µm monolithic microwave integrated circuit (MMIC) power amplifier (PA) is fabricated in a 2 µm InGaP/GaAs process. An on-chip analog pre-distorter (APD) is designed to improve the linearity of the PA, up to 20 MHz channel bandwidth. Intended for 1.95 GHz Band 1 LTE application, the PA satisfies adjacent channel leakage ratio (ACLR) and error vector magnitude (EVM) specifications for a wide LTE channel bandwidth of 20 MHz at a linear output power of 28 dBm with corresponding power added efficiency (PAE) of 52.3%. With a respective input and output return loss of 30 dB and 14 dB, the PA's power gain is measured to be 32.5 dB while exhibiting an unconditional stability characteristic from DC up to 5 GHz. The proposed APD technique serves to be a good solution to improve linearity of a PA without sacrificing other critical performance metrics.

Wideband LTE Power Amplifier with Integrated Novel Analog Pre-Distorter Linearizer for Mobile Wireless Communications

Science.gov (United States)

Uthirajoo, Eswaran; Ramiah, Harikrishnan; Kanesan, Jeevan; Reza, Ahmed Wasif

2014-01-01

For the first time, a new circuit to extend the linear operation bandwidth of a LTE (Long Term Evolution) power amplifier, while delivering a high efficiency is implemented in less than 1 mm2 chip area. The 950 µm × 900 µm monolithic microwave integrated circuit (MMIC) power amplifier (PA) is fabricated in a 2 µm InGaP/GaAs process. An on-chip analog pre-distorter (APD) is designed to improve the linearity of the PA, up to 20 MHz channel bandwidth. Intended for 1.95 GHz Band 1 LTE application, the PA satisfies adjacent channel leakage ratio (ACLR) and error vector magnitude (EVM) specifications for a wide LTE channel bandwidth of 20 MHz at a linear output power of 28 dBm with corresponding power added efficiency (PAE) of 52.3%. With a respective input and output return loss of 30 dB and 14 dB, the PA’s power gain is measured to be 32.5 dB while exhibiting an unconditional stability characteristic from DC up to 5 GHz. The proposed APD technique serves to be a good solution to improve linearity of a PA without sacrificing other critical performance metrics. PMID:25033049

Analog and mixed-signal electronics

CERN Document Server

Stephan, Karl

2015-01-01

A practical guide to analog and mixed-signal electronics, with an emphasis on design problems and applications This book provides an in-depth coverage of essential analog and mixed-signal topics such as power amplifiers, active filters, noise and dynamic range, analog-to-digital and digital-to-analog conversion techniques, phase-locked loops, and switching power supplies. Readers will learn the basics of linear systems, types of nonlinearities and their effects, op-amp circuits, the high-gain analog filter-amplifier, and signal generation. The author uses system design examples to motivate

Meat analog: a review.

Science.gov (United States)

Malav, O P; Talukder, S; Gokulakrishnan, P; Chand, S

2015-01-01

The health-conscious consumers are in search of nutritious and convenient food item which can be best suited in their busy life. The vegetarianism is the key for the search of such food which resembles the meat in respect of nutrition and sensory characters, but not of animal origin and contains vegetable or its modified form, this is the point when meat analog evolved out and gets shape. The consumers gets full satisfaction by consumption of meat analog due to its typical meaty texture, appearance and the flavor which are being imparted during the skilled production of meat analog. The supplement of protein in vegetarian diet through meat alike food can be fulfilled by incorporating protein-rich vegetative food grade materials in meat analog and by adopting proper technological process which can promote the proper fabrication of meat analog with acceptable meat like texture, appearance, flavor, etc. The easily available vegetables, cereals, and pulses in India have great advantages and prospects to be used in food products and it can improve the nutritional and functional characters of the food items. The various form and functional characters of food items are available world over and attracts the meat technologists and the food processors to bring some innovativeness in meat analog and its presentation and marketability so that the acceptability of meat analog can be overgrown by the consumers.

Digital and analog communication systems

Science.gov (United States)

Shanmugam, K. S.

1979-01-01

The book presents an introductory treatment of digital and analog communication systems with emphasis on digital systems. Attention is given to the following topics: systems and signal analysis, random signal theory, information and channel capacity, baseband data transmission, analog signal transmission, noise in analog communication systems, digital carrier modulation schemes, error control coding, and the digital transmission of analog signals.

Automatic analog IC sizing and optimization constrained with PVT corners and layout effects

CERN Document Server

Lourenço, Nuno; Horta, Nuno

2017-01-01

This book introduces readers to a variety of tools for automatic analog integrated circuit (IC) sizing and optimization. The authors provide a historical perspective on the early methods proposed to tackle automatic analog circuit sizing, with emphasis on the methodologies to size and optimize the circuit, and on the methodologies to estimate the circuit’s performance. The discussion also includes robust circuit design and optimization and the most recent advances in layout-aware analog sizing approaches. The authors describe a methodology for an automatic flow for analog IC design, including details of the inputs and interfaces, multi-objective optimization techniques, and the enhancements made in the base implementation by using machine leaning techniques. The Gradient model is discussed in detail, along with the methods to include layout effects in the circuit sizing. The concepts and algorithms of all the modules are thoroughly described, enabling readers to reproduce the methodologies, improve the qual...

Intensive fibrosarcoma-binding capability of the reconstituted analog and its antitumor activity.

Science.gov (United States)

Xu, Jian; Du, Yue; Liu, Wen-Juan; Li, Liang; Li, Yi; Wang, Xiao-Fei; Yi, Hong-Fei; Shan, Chuan-Kun; Xia, Gui-Min; Liu, Xiu-Jun; Zhen, Yong-Su

2018-11-01

Fibrosarcomas are highly aggressive malignant tumors. It is urgently needed to explore targeted drugs and modalities for more effective therapy. Matrix metalloproteinases (MMPs) play important roles in tumor progression and metastasis, while several MMPs are highly expressed in fibrosarcomas. In addition, tissue inhibitor of metalloproteinase 2 (TIMP2) displays specific interaction with MMPs. Therefore, TIMP2 may play an active role in the development of fibrosarcoma-targeting agents. In the current study, a TIMP2-based recombinant protein LT and its enediyne-integrated analog LTE were prepared; furthermore, the fibrosarcoma-binding intensity and antitumor activity were investigated. As shown, intense and selective binding capability of the protein LT to human fibrosarcoma specimens was confirmed by tissue microarray. Moreover, LTE, the enediyne-integrated analog of LT, exerted highly potent cytotoxicity to fibrosarcoma HT1080 cells, induced apoptosis, and caused G2/M arrest. LTE at 0.1 nM markedly suppressed the migration and invasion of HT1080 cells. LTE at tolerated dose of 0.6 mg/kg inhibited the tumor growth of fibrosarcoma xenograft in athymic mice. The study provides evidence that the TIMP2-based reconstituted analog LTE may be useful as a targeted drug for fibrosarcome therapy.

Children's Development of Analogical Reasoning: Insights from Scene Analogy Problems

Science.gov (United States)

Richland, Lindsey E.; Morrison, Robert G.; Holyoak, Keith J.

2006-01-01

We explored how relational complexity and featural distraction, as varied in scene analogy problems, affect children's analogical reasoning performance. Results with 3- and 4-year-olds, 6- and 7-year-olds, 9- to 11-year-olds, and 13- and 14-year-olds indicate that when children can identify the critical structural relations in a scene analogy…

Hydraulic Capacitor Analogy

Science.gov (United States)

Baser, Mustafa

2007-01-01

Students have difficulties in physics because of the abstract nature of concepts and principles. One of the effective methods for overcoming students' difficulties is the use of analogies to visualize abstract concepts to promote conceptual understanding. According to Iding, analogies are consistent with the tenets of constructivist learning…

Analog fourier transform channelizer and OFDM receiver

OpenAIRE

2007-01-01

An OFDM receiver having an analog multiplier based I-Q channelizing filter, samples and holds consecutive analog I-Q samples of an I-Q baseband, the I-Q basebands having OFDM sub-channels. A lattice of analog I-Q multipliers and analog I-Q summers concurrently receives the held analog I-Q samples, performs analog I-Q multiplications and analog I-Q additions to concurrently generate a plurality of analog I-Q output signals, representing an N-point discrete Fourier transform of the held analog ...

Plant a tree in cyberspace: metaphor and analogy as design elements in Web-based learning environments.

Science.gov (United States)

Wolfe, C R

2001-02-01

Analogy and metaphor are figurative forms of communication that help people integrate new information with prior knowledge to facilitate comprehension and appropriate inferences. The novelty and versatility of the Web place cognitive burdens on learners that can be overcome through the use of analogies and metaphors. This paper explores three uses of figurative communication as design elements in Web-based learning environments, and provides empirical illustrations of each. First, extended analogies can be used as the basis of cover stories that create an analogy between the learner's position and a hypothetical situation. The Dragonfly Web pages make extensive use of analogous cover stories in the design of interactive decision-making games. Feedback from visitors, patterns of usage, and external reviews provide evidence of effectiveness. A second approach is visual analogies based on the principles of ecological psychology. An empirical example suggests that visual analogies are most effective when there is a one-to-one correspondence between the base and visual target analogs. The use of learner-generated analogies is a third approach. Data from an offline study with undergraduate science students are presented indicating that generating analogies are associated with significant improvements in the ability to place events in natural history on a time line. It is concluded that cyberspace itself might form the basis of the next guiding metaphor of mind.

Ultra low-power biomedical signal processing : An analog wavelet filter approach for pacemakers

NARCIS (Netherlands)

Pavlík Haddad, S.A.

2006-01-01

The purpose of this thesis is to describe novel signal processing methodologies and analog integrated circuit techniques for low-power biomedical systems. Physiological signals, such as the electrocardiogram (ECG), the electroencephalogram (EEG) and the electromyogram (EMG) are mostly

Outcropping analogs and multiscale fracture patterns in the Jandaíra formation

NARCIS (Netherlands)

Bertotti, G.; Bezerra, F.H.; Bisdom, K.; Cazarin, C.; Reijmer, J.

2013-01-01

Outcropping analogs can provide key information on the 3D organization of fracture networks affecting carbonate reservoirs. Such information, however, needs to be integrated in a consistent work flow which includes i) 3D geometric model of the reservoir architecture, ii) mechanic modeling to

Path probability distribution of stochastic motion of non dissipative systems: a classical analog of Feynman factor of path integral

International Nuclear Information System (INIS)

Lin, T.L.; Wang, R.; Bi, W.P.; El Kaabouchi, A.; Pujos, C.; Calvayrac, F.; Wang, Q.A.

2013-01-01

We investigate, by numerical simulation, the path probability of non dissipative mechanical systems undergoing stochastic motion. The aim is to search for the relationship between this probability and the usual mechanical action. The model of simulation is a one-dimensional particle subject to conservative force and Gaussian random displacement. The probability that a sample path between two fixed points is taken is computed from the number of particles moving along this path, an output of the simulation, divided by the total number of particles arriving at the final point. It is found that the path probability decays exponentially with increasing action of the sample paths. The decay rate increases with decreasing randomness. This result supports the existence of a classical analog of the Feynman factor in the path integral formulation of quantum mechanics for Hamiltonian systems

Inductive, Analogical, and Communicative Generalization

Directory of Open Access Journals (Sweden)

Adri Smaling

2003-03-01

Full Text Available Three forms of inductive generalization - statistical generalization, variation-based generalization and theory-carried generalization - are insufficient concerning case-to-case generalization, which is a form of analogical generalization. The quality of case-to-case generalization needs to be reinforced by setting up explicit analogical argumentation. To evaluate analogical argumentation six criteria are discussed. Good analogical reasoning is an indispensable support to forms of communicative generalization - receptive and responsive (participative generalization — as well as exemplary generalization.

An express method for optimally tuning an analog controller with respect to integral quality criteria

Science.gov (United States)

Golinko, I. M.; Kovrigo, Yu. M.; Kubrak, A. I.

2014-03-01

An express method for optimally tuning analog PI and PID controllers is considered. An integral quality criterion with minimizing the control output is proposed for optimizing control systems. The suggested criterion differs from existing ones in that the control output applied to the technological process is taken into account in a correct manner, due to which it becomes possible to maximally reduce the expenditure of material and/or energy resources in performing control of industrial equipment sets. With control organized in such manner, smaller wear and longer service life of control devices are achieved. A unimodal nature of the proposed criterion for optimally tuning a controller is numerically demonstrated using the methods of optimization theory. A functional interrelation between the optimal controller parameters and dynamic properties of a controlled plant is numerically determined for a single-loop control system. The results obtained from simulation of transients in a control system carried out using the proposed and existing functional dependences are compared with each other. The proposed calculation formulas differ from the existing ones by a simple structure and highly accurate search for the optimal controller tuning parameters. The obtained calculation formulas are recommended for being used by specialists in automation for design and optimization of control systems.

New technologies for radiation-hardening analog to digital converters

International Nuclear Information System (INIS)

Gauthier, M.K.

1982-12-01

Surveys of available Analog to Digital Converters (ADC) suitable for precision applications showed that none have the proper combination of accuracy and radiation hardness to meet space and/or strategic weapon requirements. A development program which will result in an ADC device which will serve a number of space and strategic applications. Emphasis was placed on approaches that could be integrated onto a single chip within three to five years

New technologies for radiation-hardening analog to digital converters

Science.gov (United States)

Gauthier, M. K.

1982-01-01

Surveys of available Analog to Digital Converters (ADC) suitable for precision applications showed that none have the proper combination of accuracy and radiation hardness to meet space and/or strategic weapon requirements. A development program which will result in an ADC device which will serve a number of space and strategic applications. Emphasis was placed on approaches that could be integrated onto a single chip within three to five years.

Space Medicine in the Human System Integration Process

Science.gov (United States)

Scheuring, Richard A.

2010-01-01

This slide presentation reviews the importance of integration of space medicine in the human system of lunar exploration. There is a review of historical precedence in reference to lunar surface operations. The integration process is reviewed in a chart which shows the steps from research to requirements development, requirements integration, design, verification, operations and using the lessons learned, giving more information and items for research. These steps are reviewed in view of specific space medical issues. Some of the testing of the operations are undertaken in an environment that is an analog to the exploration environment. Some of these analog environments are reviewed, and there is some discussion of the benefits of use of an analog environment in testing the processes that are derived.

Analogical Reasoning and Computer Programming.

Science.gov (United States)

Clement, Catherine A.; And Others

1986-01-01

A study of correlations between analogical reasoning and Logo programming mastery among female high school students related the results of pretests of analogical reasoning to posttests of programming mastery. A significant correlation was found between analogical reasoning and the ability to write subprocedures for use in several different…

An analysis of stripping to isolated analog resonances

International Nuclear Information System (INIS)

Pessoa, E.F.; Toledo Piza, A.F.R. de.

1983-04-01

The Feshbach projection formalism is used to calculate the form factors for the (d,n) stripping process to isolated analog resonances. These are used in a standard DWBA stripping calculation in which the radial integration over all space is accomplished by including outerspace contributions evaluated along the complex contours of Vincent and Fortune. It turns out that the shape and magnitude of the predicted cross section is quite insensitive to the continuum proton wave emanating from the resonant residual state. (Author) [pt

Optical modulation techniques for analog signal processing and CMOS compatible electro-optic modulation

Science.gov (United States)

Gill, Douglas M.; Rasras, Mahmoud; Tu, Kun-Yii; Chen, Young-Kai; White, Alice E.; Patel, Sanjay S.; Carothers, Daniel; Pomerene, Andrew; Kamocsai, Robert; Beattie, James; Kopa, Anthony; Apsel, Alyssa; Beals, Mark; Mitchel, Jurgen; Liu, Jifeng; Kimerling, Lionel C.

2008-02-01

Integrating electronic and photonic functions onto a single silicon-based chip using techniques compatible with mass-production CMOS electronics will enable new design paradigms for existing system architectures and open new opportunities for electro-optic applications with the potential to dramatically change the management, cost, footprint, weight, and power consumption of today's communication systems. While broadband analog system applications represent a smaller volume market than that for digital data transmission, there are significant deployments of analog electro-optic systems for commercial and military applications. Broadband linear modulation is a critical building block in optical analog signal processing and also could have significant applications in digital communication systems. Recently, broadband electro-optic modulators on a silicon platform have been demonstrated based on the plasma dispersion effect. The use of the plasma dispersion effect within a CMOS compatible waveguide creates new challenges and opportunities for analog signal processing since the index and propagation loss change within the waveguide during modulation. We will review the current status of silicon-based electrooptic modulators and also linearization techniques for optical modulation.

Integration of Biological, Physical/Chemical and Energy Efficient Systems in the CELSS Antarctic Analog: Performance of Prototype Systems and Issues for Life Support

Science.gov (United States)

Bubenheim, David L.; Flynn, Michael T.; Lamparter, Richard; Bates, Maynard; Kliss, Mark (Technical Monitor)

1998-01-01

The Controlled Ecological Life Support System (CELSS) Antarctic Analog Project (CAAP) is a joint endeavor between the National Science Foundation, Office of Polar Programs (NSF-OPP), and the National Aeronautics and Space Administration (NASA). The fundamental objective is to develop, deploy, and operate a testbed of advanced life support technologies at the Amundsen-Scott South Pole Station that enable the objectives of both the NSF and NASA. The functions of food production, water purification, and waste treatment, recycle, and reduction provided by CAAP will improve the quality of life for the South Pole inhabitants, reduce logistics dependence, enhance safety, and minimize environmental impacts associated with human presence on the polar plateau. Because of the analogous technical, scientific, and mission features with Planetary missions, such as a mission to Mars, CAAP provides NASA with a method for validating technologies and overall approaches to supporting humans. Prototype systems for waste treatment, water recycle, resource recovery and crop production are being evaluated in a testbed at Ames Research Center. The combined performance of these biological and physical/chemical systems as an integrated function in support of the human habitat will be discussed. Overall system performance will be emphasized. The effectiveness and efficiency of component technologies will be discussed in the context of energy and mass flow within the system and contribution to achieving a mass and energy conservative system. Critical to the discussion are interfaces with habitat functions outside of the closed-loop life support: the ability of the system to satisfy the life support requirements of the habitat and the ability to define input requirements. The significance of analog functions in relation to future Mars habitats will be discussed.

Analogical reasoning in children with specific language impairment: Evidence from a scene analogy task.

Science.gov (United States)

Krzemien, Magali; Jemel, Boutheina; Maillart, Christelle

2017-01-01

Analogical reasoning is a human ability that maps systems of relations. It develops along with relational knowledge, working memory and executive functions such as inhibition. It also maintains a mutual influence on language development. Some authors have taken a greater interest in the analogical reasoning ability of children with language disorders, specifically those with specific language impairment (SLI). These children apparently have weaker analogical reasoning abilities than their aged-matched peers without language disorders. Following cognitive theories of language acquisition, this deficit could be one of the causes of language disorders in SLI, especially those concerning productivity. To confirm this deficit and its link to language disorders, we use a scene analogy task to evaluate the analogical performance of SLI children and compare them to controls of the same age and linguistic abilities. Results show that children with SLI perform worse than age-matched peers, but similar to language-matched peers. They are more influenced by increased task difficulty. The association between language disorders and analogical reasoning in SLI can be confirmed. The hypothesis of limited processing capacity in SLI is also being considered.

PEMETAAN ANALOGI PADA KONSEP ABSTRAK FISIKA

Directory of Open Access Journals (Sweden)

Nyoto Suseno

2014-11-01

Full Text Available The research of any where founded majority students have common difficulties in abstract physics concept. The result of observation, lecturers have problem  in teaching implementation of abstract concepts on physics learning. The objective of this research is to find out the ways how to overcome this problem. The research place of  physics education programs and senior high school. The data are colected by quetionere, observation and interview. The lecturer behavior to making out this case is use of analogy to make concrete a abstract concept. This action is true, because the analogies are dynamic tools that facilitate understanding, rather than representations of the correct and static explanations. Using analogies not only promoted profound understanding of abstract concept, but also helped students overcome their misconceptions. However used analogy in teaching not yet planed with seriousness, analogy used spontanously with the result that less optimal. By planing and selecting right analogy, the role of analogy can be achieved the optimal result. Therefore, it is important to maping analogies of abstract consepts on physics learning.

Science Teachers' Analogical Reasoning

Science.gov (United States)

Mozzer, Nilmara Braga; Justi, Rosária

2013-01-01

Analogies can play a relevant role in students' learning. However, for the effective use of analogies, teachers should not only have a well-prepared repertoire of validated analogies, which could serve as bridges between the students' prior knowledge and the scientific knowledge they desire them to understand, but also know how to…

Analog circuits cookbook

CERN Document Server

Hickman, Ian

2013-01-01

Analog Circuits Cookbook presents articles about advanced circuit techniques, components and concepts, useful IC for analog signal processing in the audio range, direct digital synthesis, and ingenious video op-amp. The book also includes articles about amplitude measurements on RF signals, linear optical imager, power supplies and devices, and RF circuits and techniques. Professionals and students of electrical engineering will find the book informative and useful.

A behavioral simulator for switched-capacitor sigma-delta modulator analog-to-digital converter

International Nuclear Information System (INIS)

San, H. Y.; Rezaul Hasan, S. M.

1998-01-01

In this paper, a PC-based simulator for state of the art oversampled switched-capacitor sigma-delta analog-to-digital converters is presented. The proposed simulator employs behavioral model of switched-capacitor integrator and non-linear quantizer to stimulate the system. The behavioral simulation of the integrator is also verified with SPICE. The simulator is fully integrated and standalone. It integrates an input netlist file interpreter, a behavioral simulator, a generic part library and a powerful post-processor to evaluate the SNR, SDR And TSNR. Both passive and active sensitivities can be investigated by the proposed simulator. The simulator is coded in C++, and is very fast

A reconfigurable analog baseband circuit for WLAN, WCDMA, and Bluetooth

International Nuclear Information System (INIS)

Tong Tao; Chi Baoyong; Wang Ziqiang; Zhang Ying; Jiang Hanjun; Wang Zhihua

2010-01-01

A reconfigurable analog baseband circuit for WLAN, WCDMA, and Bluetooth in 0.35 μm CMOS is presented. The circuit consists of two variable gain amplifiers (VGA) in cascade and a G m -C elliptic low-pass filter (LPF). The filter-order and the cut-off frequency of the LPF can be reconfigured to satisfy the requirements of various applications. In order to achieve the optimum power consumption, the bandwidth of the VGAs can also be dynamically reconfigured and some G m cells can be cut off in the given application. Simulation results show that the analog baseband circuit consumes 16.8 mW for WLAN, 8.9 mW for WCDMA and only 6.5 mW for Bluetooth, all with a 3 V power supply. The analog baseband circuit could provide -10 to +40 dB variable gain, third-order low pass filtering with 1 MHz cut-off frequency for Bluetooth, fourth-order low pass filtering with 2.2 MHz cut-off frequency for WCDMA, and fifth-order low pass filtering with 11 MHz cut-off frequency for WLAN, respectively. (semiconductor integrated circuits)

A reconfigurable analog baseband circuit for WLAN, WCDMA, and Bluetooth

Energy Technology Data Exchange (ETDEWEB)

Tong Tao; Chi Baoyong; Wang Ziqiang; Zhang Ying; Jiang Hanjun; Wang Zhihua, E-mail: tongt05@gmail.co [Institute of Microelectronics, Tsinghua University, Beijing 100084 (China)

2010-05-15

A reconfigurable analog baseband circuit for WLAN, WCDMA, and Bluetooth in 0.35 {mu}m CMOS is presented. The circuit consists of two variable gain amplifiers (VGA) in cascade and a G{sub m}-C elliptic low-pass filter (LPF). The filter-order and the cut-off frequency of the LPF can be reconfigured to satisfy the requirements of various applications. In order to achieve the optimum power consumption, the bandwidth of the VGAs can also be dynamically reconfigured and some G{sub m} cells can be cut off in the given application. Simulation results show that the analog baseband circuit consumes 16.8 mW for WLAN, 8.9 mW for WCDMA and only 6.5 mW for Bluetooth, all with a 3 V power supply. The analog baseband circuit could provide -10 to +40 dB variable gain, third-order low pass filtering with 1 MHz cut-off frequency for Bluetooth, fourth-order low pass filtering with 2.2 MHz cut-off frequency for WCDMA, and fifth-order low pass filtering with 11 MHz cut-off frequency for WLAN, respectively. (semiconductor integrated circuits)

Students' Pre- and Post-Teaching Analogical Reasoning when They Draw Their Analogies

Science.gov (United States)

Mozzer, Nilmara Braga; Justi, Rosaria

2012-01-01

Analogies are parts of human thought. From them, we can acquire new knowledge or change that which already exists in our cognitive structure. In this sense, understanding the analogical reasoning process becomes an essential condition to understand how we learn. Despite the importance of such an understanding, there is no general agreement in…

Analogical proportions: another logical view

Science.gov (United States)

Prade, Henri; Richard, Gilles

This paper investigates the logical formalization of a restricted form of analogical reasoning based on analogical proportions, i.e. statements of the form a is to b as c is to d. Starting from a naive set theoretic interpretation, we highlight the existence of two noticeable companion proportions: one states that a is to b the converse of what c is to d (reverse analogy), while the other called paralogical proportion expresses that what a and b have in common, c and d have it also. We identify the characteristic postulates of the three types of proportions and examine their consequences from an abstract viewpoint. We further study the properties of the set theoretic interpretation and of the Boolean logic interpretation, and we provide another light on the understanding of the role of permutations in the modeling of the three types of proportions. Finally, we address the use of these proportions as a basis for inference in a propositional setting, and relate it to more general schemes of analogical reasoning. The differences between analogy, reverse-analogy, and paralogy is still emphasized in a three-valued setting, which is also briefly presented.

Disfigured anatomies and imperfect analogies: body integrity identity disorder and the supposed right to self-demanded amputation of healthy body parts.

Science.gov (United States)

Patrone, D

2009-09-01

Patients with the controversial diagnosis of body integrity identity disorder (BIID) report an emotional discomfort with having a body part (usually a limb) that they feel should not be there. This discomfort is so strong that it interferes with routine functioning and, in a majority of cases, BIID patients are motivated to seek amputation of the limb. Although patient requests to receive the best available treatment are generally respected, BIID demands for amputation, at present, are not. However, what little has been said in the ethics literature on the subject tends to favour doing so in cases of BIID. The general argument is that BIID demands should be respected, first, because of the importance that is already placed on respecting autonomy in medical decision-making contexts and second, because of the potential harm of not providing amputation coupled with the fact that no alternative means of relieving suffering exists. The defence of the right to self-demanded amputation is thus typically supported by the use of analogies with other unproblematical cases in order to show that the denial of BIID patient demands is inconsistent with conventional medical norms and practices. This paper criticises the appropriateness of the particular analogies that are thought to shed light on the allegedly unproblematical nature of BIID demands and argues that a proper understanding of the respect for autonomy in the medical decision-making context prohibits agreeing to BIID demands for amputation.

Analog circuit design art, science and personalities

CERN Document Server

Williams, Jim

1991-01-01

This book is far more than just another tutorial or reference guide - it's a tour through the world of analog design, combining theory and applications with the philosophies behind the design process. Readers will learn how leading analog circuit designers approach problems and how they think about solutions to those problems. They'll also learn about the `analog way' - a broad, flexible method of thinking about analog design tasks.A comprehensive and useful guide to analog theory and applications. Covers visualizing the operation of analog circuits. Looks at how to rap

Resistive RAMs as analog trimming elements

Science.gov (United States)

Aziza, H.; Perez, A.; Portal, J. M.

2018-04-01

This work investigates the use of Resistive Random Access Memory (RRAM) as an analog trimming device. The analog storage feature of the RRAM cell is evaluated and the ability of the RRAM to hold several resistance states is exploited to propose analog trim elements. To modulate the memory cell resistance, a series of short programming pulses are applied across the RRAM cell allowing a fine calibration of the RRAM resistance. The RRAM non volatility feature makes the analog device powers up already calibrated for the system in which the analog trimmed structure is embedded. To validate the concept, a test structure consisting of a voltage reference is evaluated.

Fast multichannel analog storage system

International Nuclear Information System (INIS)

Freytag, D.R.

1982-11-01

A Multichannel Analog Storage System based on a commercial 32-channel parallel in/serial out (PISO) analog shift register is described. The basic unit is a single width CAMAC module containing 512 analog cells and the associated logic for data storage and subsequent readout. At sampling rates of up to 30 MHz the signals are strobed directly into the PISO. At higher rates signals are strobed into a fast presampling stage and subsequently transferred in block form into an array of PISO's. Sampling rates of 300 MHz have been achieved with the present device and 1000 MHz are possible with improved signal drivers. The system is well suited for simultaneous handling of many signal channels with moderate numbers of samples in each channel. RMS noise over full scale signal has been measured as 1:3000 (approx. = 11 bit). However, nonlinearities in the response and differences in sensitivity of the analog cells require an elaborate calibration system in order to realize 11 bit accuracy for the analog information

Purification and partial characterization of analogous 26-kDa rat submandibular and parotid gland integral membrane phosphoproteins that may have a role in exocytosis.

Science.gov (United States)

Quissell, D O; Deisher, L M

1992-04-01

Rat submandibular and parotid gland exocytosis is primarily controlled by beta-adrenergic receptor stimulation. Although its precise role in the regulation of salivary gland exocytosis is not fully understood, protein phosphorylation, mediated by the activation of cAMP-dependent protein kinase, may be directly involved. Previous studies suggest that analogous 26-kDa integral membrane phosphoproteins may play a direct role in regulating exocytosis. Studies were here undertaken to purify and partially characterize both phosphoproteins. After endogenous phosphorylation with 32P, subcellular fraction and solubilization of the microsomal fraction in n-octyl beta-glucopyranoside, the 26-kDa integral membrane phosphoproteins were purified by high performance liquid chromatography (HPLC), followed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis and electroelution of the proteins. Amino acid analysis indicated a significant number of serine amino acids: N-terminal sequence data demonstrated a high level of homology; and trypsin digestion followed by reversed-phase HPLC indicated the possibility of multiple phosphorylation sites.

SSERVI Analog Regolith Simulant Testbed Facility

Science.gov (United States)

Minafra, Joseph; Schmidt, Gregory; Bailey, Brad; Gibbs, Kristina

2016-10-01

The Solar System Exploration Research Virtual Institute (SSERVI) at NASA's Ames Research Center in California's Silicon Valley was founded in 2013 to act as a virtual institute that provides interdisciplinary research centered on the goals of its supporting directorates: NASA Science Mission Directorate (SMD) and the Human Exploration & Operations Mission Directorate (HEOMD).Primary research goals of the Institute revolve around the integration of science and exploration to gain knowledge required for the future of human space exploration beyond low Earth orbit. SSERVI intends to leverage existing JSC1A regolith simulant resources into the creation of a regolith simulant testbed facility. The purpose of this testbed concept is to provide the planetary exploration community with a readily available capability to test hardware and conduct research in a large simulant environment.SSERVI's goals include supporting planetary researchers within NASA, other government agencies; private sector and hardware developers; competitors in focused prize design competitions; and academic sector researchers.SSERVI provides opportunities for research scientists and engineers to study the effects of regolith analog testbed research in the planetary exploration field. This capability is essential to help to understand the basic effects of continued long-term exposure to a simulated analog test environment.The current facility houses approximately eight tons of JSC-1A lunar regolith simulant in a test bin consisting of a 4 meter by 4 meter area, including dust mitigation and safety oversight.Facility hardware and environment testing scenarios could include, Lunar surface mobility, Dust exposure and mitigation, Regolith handling and excavation, Solar-like illumination, Lunar surface compaction profile, Lofted dust, Mechanical properties of lunar regolith, Surface features (i.e. grades and rocks)Numerous benefits vary from easy access to a controlled analog regolith simulant testbed, and

Analogy Lays the Foundation for Two Crucial Aspects of Symbolic Development: Intention and Correspondence.

Science.gov (United States)

Yuan, Lei; Uttal, David H

2017-07-01

We argue that analogical reasoning, particularly Gentner's (1983, 2010) structure-mapping theory, provides an integrative theoretical framework through which we can better understand the development of symbol use. Analogical reasoning can contribute both to the understanding of others' intentions and the establishment of correspondences between symbols and their referents, two crucial components of symbolic understanding. We review relevant research on the development of symbolic representations, intentionality, comparison, and similarity, and demonstrate how structure-mapping theory can shed light on several ostensibly disparate findings in the literature. Focusing on visual symbols (e.g., scale models, photographs, and maps), we argue that analogy underlies and supports the understanding of both intention and correspondence, which may enter into a reciprocal bootstrapping process that leads children to gain the prodigious human capacity of symbol use. Copyright © 2017 Cognitive Science Society, Inc.

General and specialized brain correlates for analogical reasoning: A meta-analysis of functional imaging studies.

Science.gov (United States)

Hobeika, Lucie; Diard-Detoeuf, Capucine; Garcin, Béatrice; Levy, Richard; Volle, Emmanuelle

2016-05-01

Reasoning by analogy allows us to link distinct domains of knowledge and to transfer solutions from one domain to another. Analogical reasoning has been studied using various tasks that have generally required the consideration of the relationships between objects and their integration to infer an analogy schema. However, these tasks varied in terms of the level and the nature of the relationships to consider (e.g., semantic, visuospatial). The aim of this study was to identify the cerebral network involved in analogical reasoning and its specialization based on the domains of information and task specificity. We conducted a coordinate-based meta-analysis of 27 experiments that used analogical reasoning tasks. The left rostrolateral prefrontal cortex was one of the regions most consistently activated across the studies. A comparison between semantic and visuospatial analogy tasks showed both domain-oriented regions in the inferior and middle frontal gyri and a domain-general region, the left rostrolateral prefrontal cortex, which was specialized for analogy tasks. A comparison of visuospatial analogy to matrix problem tasks revealed that these two relational reasoning tasks engage, at least in part, distinct right and left cerebral networks, particularly separate areas within the left rostrolateral prefrontal cortex. These findings highlight several cognitive and cerebral differences between relational reasoning tasks that can allow us to make predictions about the respective roles of distinct brain regions or networks. These results also provide new, testable anatomical hypotheses about reasoning disorders that are induced by brain damage. Hum Brain Mapp 37:1953-1969, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Analog front-end for pixel sensors in a 3D CMOS technology for the SuperB Layer0

International Nuclear Information System (INIS)

Manazza, A.; Gaioni, L.; Re, V.

2011-01-01

This work is concerned with the design of two different analog channels for hybrid and monolithic pixels readout in view of applications to the SVT at the SuperB Factory. The circuits have been designed in a 130nm CMOS, vertically integrated technology, which, among others, may provide some advantages in terms of functional density and electrical isolation between the analog and the digital sections of the front-end.

Electrical Circuits and Water Analogies

Science.gov (United States)

Smith, Frederick A.; Wilson, Jerry D.

1974-01-01

Briefly describes water analogies for electrical circuits and presents plans for the construction of apparatus to demonstrate these analogies. Demonstrations include series circuits, parallel circuits, and capacitors. (GS)

Producing and Recognizing Analogical Relations

Science.gov (United States)

Lipkens, Regina; Hayes, Steven C

2009-01-01

Analogical reasoning is an important component of intelligent behavior, and a key test of any approach to human language and cognition. Only a limited amount of empirical work has been conducted from a behavior analytic point of view, most of that within Relational Frame Theory (RFT), which views analogy as a matter of deriving relations among relations. The present series of four studies expands previous work by exploring the applicability of this model of analogy to topography-based rather than merely selection-based responses and by extending the work into additional relations, including nonsymmetrical ones. In each of the four studies participants pretrained in contextual control over nonarbitrary stimulus relations of sameness and opposition, or of sameness, smaller than, and larger than, learned arbitrary stimulus relations in the presence of these relational cues and derived analogies involving directly trained relations and derived relations of mutual and combinatorial entailment, measured using a variety of productive and selection-based measures. In Experiment 1 participants successfully recognized analogies among stimulus networks containing same and opposite relations; in Experiment 2 analogy was successfully used to extend derived relations to pairs of novel stimuli; in Experiment 3 the procedure used in Experiment 1 was extended to nonsymmetrical comparative relations; in Experiment 4 the procedure used in Experiment 2 was extended to nonsymmetrical comparative relations. Although not every participant showed the effects predicted, overall the procedures occasioned relational responses consistent with an RFT account that have not yet been demonstrated in a behavior-analytic laboratory setting, including productive responding on the basis of analogies. PMID:19230515

Challenges in Using Analogies

Science.gov (United States)

Lin, Shih-Yin; Singh, Chandralekha

2011-01-01

Learning physics requires understanding the applicability of fundamental principles in a variety of contexts that share deep features. One way to help students learn physics is via analogical reasoning. Students can be taught to make an analogy between situations that are more familiar or easier to understand and another situation where the same…

The Micro-Category Account of Analogy

Science.gov (United States)

Green, Adam E.; Fugelsang, Jonathan A.; Kraemer, David J. M.; Dunbar, Kevin N.

2008-01-01

Here, we investigate how activation of mental representations of categories during analogical reasoning influences subsequent cognitive processing. Specifically, we present and test the central predictions of the "Micro-Category" account of analogy. This account emphasizes the role of categories in aligning terms for analogical mapping. In a…

Priming analogical reasoning with false memories.

Science.gov (United States)

Howe, Mark L; Garner, Sarah R; Threadgold, Emma; Ball, Linden J

2015-08-01

Like true memories, false memories are capable of priming answers to insight-based problems. Recent research has attempted to extend this paradigm to more advanced problem-solving tasks, including those involving verbal analogical reasoning. However, these experiments are constrained inasmuch as problem solutions could be generated via spreading activation mechanisms (much like false memories themselves) rather than using complex reasoning processes. In three experiments we examined false memory priming of complex analogical reasoning tasks in the absence of simple semantic associations. In Experiment 1, we demonstrated the robustness of false memory priming in analogical reasoning when backward associative strength among the problem terms was eliminated. In Experiments 2a and 2b, we extended these findings by demonstrating priming on newly created homonym analogies that can only be solved by inhibiting semantic associations within the analogy. Overall, the findings of the present experiments provide evidence that the efficacy of false memory priming extends to complex analogical reasoning problems.

An emergent approach to analogical inference

Science.gov (United States)

Thibodeau, Paul H.; Flusberg, Stephen J.; Glick, Jeremy J.; Sternberg, Daniel A.

2013-03-01

In recent years, a growing number of researchers have proposed that analogy is a core component of human cognition. According to the dominant theoretical viewpoint, analogical reasoning requires a specific suite of cognitive machinery, including explicitly coded symbolic representations and a mapping or binding mechanism that operates over these representations. Here we offer an alternative approach: we find that analogical inference can emerge naturally and spontaneously from a relatively simple, error-driven learning mechanism without the need to posit any additional analogy-specific machinery. The results also parallel findings from the developmental literature on analogy, demonstrating a shift from an initial reliance on surface feature similarity to the use of relational similarity later in training. Variants of the model allow us to consider and rule out alternative accounts of its performance. We conclude by discussing how these findings can potentially refine our understanding of the processes that are required to perform analogical inference.

Children's analogical reasoning about natural phenomena.

Science.gov (United States)

Pauen, S; Wilkening, F

1997-10-01

This report investigates children's analogical reasoning in a physics task, using an analogy generated by the children rather than by the experimenter. A total of 127 elementary school children took part in three related studies. Children learned to predict the behavior of a balance scale. Later, they were asked to solve a force interaction problem. Two versions of the balance scale training were devised: version A suggested an incorrect solution to the target problem (negative analogy), and version B suggested a correct solution to the target problem (positive analogy). In Study 1, 9- to 10-year-olds showed spontaneous transfer in both training conditions. In Study 2, 7-year-olds did not show any transfer in the positive analogy condition. Study 3 revealed that the lack of transfer in younger children was not due to a failure either to notice the analogy or to perform the mapping. Instead, 7-year-olds transferred only selected aspects of the correct solution. Copyright 1997 Academic Press.

Working memory predicts children's analogical reasoning.

Science.gov (United States)

Simms, Nina K; Frausel, Rebecca R; Richland, Lindsey E

2018-02-01

Analogical reasoning is the cognitive skill of drawing relationships between representations, often between prior knowledge and new representations, that allows for bootstrapping cognitive and language development. Analogical reasoning proficiency develops substantially during childhood, although the mechanisms underlying this development have been debated, with developing cognitive resources as one proposed mechanism. We explored the role of executive function (EF) in supporting children's analogical reasoning development, with the goal of determining whether predicted aspects of EF were related to analogical development at the level of individual differences. We assessed 5- to 11-year-old children's working memory, inhibitory control, and cognitive flexibility using measures from the National Institutes of Health Toolbox Cognition battery. Individual differences in children's working memory best predicted performance on an analogical mapping task, even when controlling for age, suggesting a fundamental interrelationship between analogical reasoning and working memory development. These findings underscore the need to consider cognitive capacities in comprehensive theories of children's reasoning development. Copyright © 2017 Elsevier Inc. All rights reserved.

Process and circuiting arrangement for the conversion of analog signals to digital signals and digital signals to analog signals

International Nuclear Information System (INIS)

Wintzer, K.

1977-01-01

Process for analog-to-digital and digital-to-analog conversion in telecommunication systems whose outstations each have an analog transmitter and an analog receiver. The invention illustrates a method of reducing the power demand of the converters at times when no conversion processes take place. (RW) [de

A Mixed Analog-Digital Radiation Hard Technology for High Energy Physics Electronics: DMILL~(Durci~Mixte~sur~Isolant~Logico-Lineaire)

CERN Multimedia

Lugiez, F; Leray, J; Rouger, M; Fourches, N T; Musseau, O; Potheau, R

2002-01-01

%RD29 %title\\\\ \\\\Physics experiments under preparation with the future LHC require a fast, low noise, very rad-hard (>10 Mrad and >10$^{14}$ neutron/cm$^{2}$), mixed analog-digital microelectronics VLSI technology.\\\\ \\\\The DMILL microelectronics technology (RD29) was developed between 1990 and 1995 by a Consortium gathering the CEA and the firm Thomson-TCS, with the collaboration of IN2P3. The goal of the DMILL program, which is now completed, was to provide the High Energy Physics community, space industry, nuclear industry, and other applications, with an industrial very rad-hard mixed analog-digital microelectronics technology.\\\\ \\\\DMILL integrates mixed analog-digital very rad-hard (>10 Mrad and >10$^{14}$ neutron/cm$^{2}$) vertical bipolar, 0.8 $\\mu$m CMOS and 1.2 $\\mu$m PJFET transistors. Its SOI substrate and its dielectric trenches strongly reduce SEU sensitivity and completely eliminate any possibility of latch-up. Its four transistors are optimized to obtain low-noise features. DMILL also integrates...

Analogies and the 5E Model

Science.gov (United States)

Orgill, Mary Kay; Thomas, Megan

2007-01-01

Science classes are full of abstract or challenging concepts that are easier to understand if an analogy is used to illustrate the points. Effective analogies motivate students, clarify students' thinking, help students overcome misconceptions, and give students ways to visualize abstract concepts. When they are used appropriately, analogies can…

How Analogy Drives Physics

International Nuclear Information System (INIS)

Hofstadter, Doug

2004-01-01

Many new ideas in theoretical physics come from analogies to older ideas in physics. For instance, the abstract notion of 'isospin' (or isotopic spin) originated in the prior concept of 'spin' (quantized angular momentum); likewise, the concept of 'phonon' (quantum of sound, or quantized collective excitation of a crystal) was based on the prior concept of 'photon' (quantum of light, or quantized element of the electromagnetic field). But these two examples, far from being exceptions, in fact represent the bread and butter of inventive thinking in physics. In a nutshell, intraphysics analogy-making -- borrowing by analogy with something already known in another area of physics -- is central to the progress of physics. The aim of this talk is to reveal the pervasiveness -- indeed, the indispensability -- of this kind of semi-irrational, wholly intuitive type of thinking (as opposed to more deductive mathematical inference) in the mental activity known as 'doing physics'. Speculations as to why wild analogical leaps are so crucial to the act of discovery in physics (as opposed to other disciplines) will be offered.

Component Processes in Analogical Reasoning

Science.gov (United States)

Sternberg, Robert J.

1977-01-01

Describes alternative theoretical positions regarding (a) the component information processes used in analogical reasoning and (b) strategies for combining these processes. Also presents results from three experiments on analogical reasoning. (Author/RK)

Is the link from working memory to analogy causal? No analogy improvements following working memory training gains.

Directory of Open Access Journals (Sweden)

J Elizabeth Richey

Full Text Available Analogical reasoning has been hypothesized to critically depend upon working memory through correlational data, but less work has tested this relationship through experimental manipulation. An opportunity for examining the connection between working memory and analogical reasoning has emerged from the growing, although somewhat controversial, body of literature suggests complex working memory training can sometimes lead to working memory improvements that transfer to novel working memory tasks. This study investigated whether working memory improvements, if replicated, would increase analogical reasoning ability. We assessed participants' performance on verbal and visual analogy tasks after a complex working memory training program incorporating verbal and spatial tasks. Participants' improvements on the working memory training tasks transferred to other short-term and working memory tasks, supporting the possibility of broad effects of working memory training. However, we found no effects on analogical reasoning. We propose several possible explanations for the lack of an impact of working memory improvements on analogical reasoning.

Is the link from working memory to analogy causal? No analogy improvements following working memory training gains.

Science.gov (United States)

Richey, J Elizabeth; Phillips, Jeffrey S; Schunn, Christian D; Schneider, Walter

2014-01-01

Analogical reasoning has been hypothesized to critically depend upon working memory through correlational data, but less work has tested this relationship through experimental manipulation. An opportunity for examining the connection between working memory and analogical reasoning has emerged from the growing, although somewhat controversial, body of literature suggests complex working memory training can sometimes lead to working memory improvements that transfer to novel working memory tasks. This study investigated whether working memory improvements, if replicated, would increase analogical reasoning ability. We assessed participants' performance on verbal and visual analogy tasks after a complex working memory training program incorporating verbal and spatial tasks. Participants' improvements on the working memory training tasks transferred to other short-term and working memory tasks, supporting the possibility of broad effects of working memory training. However, we found no effects on analogical reasoning. We propose several possible explanations for the lack of an impact of working memory improvements on analogical reasoning.

Is the Link from Working Memory to Analogy Causal? No Analogy Improvements following Working Memory Training Gains

Science.gov (United States)

Richey, J. Elizabeth; Phillips, Jeffrey S.; Schunn, Christian D.; Schneider, Walter

2014-01-01

Analogical reasoning has been hypothesized to critically depend upon working memory through correlational data [1], but less work has tested this relationship through experimental manipulation [2]. An opportunity for examining the connection between working memory and analogical reasoning has emerged from the growing, although somewhat controversial, body of literature suggests complex working memory training can sometimes lead to working memory improvements that transfer to novel working memory tasks. This study investigated whether working memory improvements, if replicated, would increase analogical reasoning ability. We assessed participants’ performance on verbal and visual analogy tasks after a complex working memory training program incorporating verbal and spatial tasks [3], [4]. Participants’ improvements on the working memory training tasks transferred to other short-term and working memory tasks, supporting the possibility of broad effects of working memory training. However, we found no effects on analogical reasoning. We propose several possible explanations for the lack of an impact of working memory improvements on analogical reasoning. PMID:25188356

Hybrid integrated sensor for position measurement

International Nuclear Information System (INIS)

Schmidt, B.; Schott, H.; Just, H.-J.

1986-01-01

The design, fabrication and performance of an integrated two-dimensional position sensitive photodetector are presented. The optoelectronic device used as sensitive element in the circuit is a full area position sensitive photodiode (PPD) with high linearity over the full sensitive area. The PPD is integrated with the analog electronics in a hybrid circuit using thick film technology. The analog electronics includes the signal amplification and the signal conditioning to form the output signals proportional to the light beam center position at the sensor surface and an output signal proportional to the light beam intensity. Using hybrid integration a new position sensitive transducer is developed giving output signals, transmiting in large distances without problems and driving directly actuators in any control system

Beginning analog electronics through projects

CERN Document Server

Singmin, Andrew

2001-01-01

Analog electronics is the simplest way to start a fun, informative, learning program. Beginning Analog Electronics Through Projects, Second Edition was written with the needs of beginning hobbyists and students in mind. This revision of Andrew Singmin's popular Beginning Electronics Through Projects provides practical exercises, building techniques, and ideas for useful electronics projects. Additionally, it features new material on analog and digital electronics, and new projects for troubleshooting test equipment.Published in the tradition of Beginning Electronics Through Projects an

A language based on analogy to communicate cultural concepts in SETI

Science.gov (United States)

Musso, Paolo

2011-02-01

The present paper is a synthesis of three presentation given by myself at the Toulouse IAC 2001 ( Analogy as a tool to communicate abstract concepts in SETI), the Bremen IAC 2003 ( From maths to culture: towards an effective message), and the Vancouver IAC 2004 ( Philosophical and religious implications of extraterrestrial intelligent life). Its aim is to find a way to make our cultural concepts understandable to hypothetical extraterrestrials (ETs) in a SETI communication. First of all, I expose the reasons why I think that analogy could be a good tool for this purpose. Then, I try to show that this is possible only in the context of an integrated language, using both abstract symbols and pictures, also sketching two practical examples about some basic concepts of our moral and religious tradition. Further studies are required to determine whether this method could be extended to the higher-level abstract concepts in the other fields of our culture. Finally, I discuss the possible role of mathematics, logic and natural science in the construction of an analogy-based language for interstellar messages with a cultural content and a possible way of managing this matter from a social point of view.

The impact of semantic distance and induced stress on analogical reasoning: a neurocomputational account.

Science.gov (United States)

Vendetti, Michael; Knowlton, Barbara J; Holyoak, Keith J

2012-12-01

In a study of reasoning with four-term verbal analogy problems, we explored the relationship between the effects of an acute, mild stressor and the complexity of the reasoning process. Participants judged whether analogy problems in the form A:B :: C:D were valid or invalid, on the basis of whether the relation in the A:B term matched that in the C:D term. Half of the problems contained a C:D pair semantically near the A:B pair (e.g., NOSE:SCENT :: TONGUE:TASTE), and the other half contained ones semantically far from A:B (e.g., NOSE:SCENT :: ANTENNA:SIGNAL). After an initial block without stress, participants were randomly assigned to count backward by 13 s from 1,000 while being told to go faster, or to count forward by 1 s from 0. The stress-induced participants reported a significant increase in state anxiety as compared to controls immediately after the mental arithmetic task. Stressed participants performed less accurately (as measured by d') on both near and far analogy problems, mainly due to an increase in false alarms. We were able to model the influence of semantic distance using the "learning and inference with schemas and analogies" (LISA) model. Our findings indicated that even mild increases in stress impair analogical reasoning. However, the decrement does not seem to directly involve the integration of relations, but rather is due to a shift in decision strategy: Under stress, people show an increased tendency to endorse analogies as valid when the terms in the individual pairs are semantically related to each other, even if the overall analogical relationship is not valid.

Analog circuit design art, science, and personalities

CERN Document Server

Williams, Jim

1991-01-01

Analog Circuit Design: Art, Science, and Personalities discusses the many approaches and styles in the practice of analog circuit design. The book is written in an informal yet informative manner, making it easily understandable to those new in the field. The selection covers the definition, history, current practice, and future direction of analog design; the practice proper; and the styles in analog circuit design. The book also includes the problems usually encountered in analog circuit design; approach to feedback loop design; and other different techniques and applications. The text is

IAEA technical meeting on integrating analog and digital instrumentation and control systems in hybrid main control rooms at nuclear power plants. Book of abstracts

Energy Technology Data Exchange (ETDEWEB)

NONE

2007-07-01

that digital technology offers are needed to increase cost-effective electricity production. As an integral part of the I and C modernization program at a nuclear power plant, the control room and other human-system interfaces (HSIs) will also be modernized. To support safe and effective operation, it is critical to specify, design, implement, operate, and maintain, as well as train for, the control room and HSI changes to take advantage of human cognitive processing abilities. This consideration of human factors is essential to increase performance and to reduce the likelihood of human errors. The plant I and C and HSI modifications can affect personnel in various ways. They can impact the role of personnel, the tasks to be performed, the way tasks are performed, and the knowledge, skills and training required of personnel. As part of modernization, HSIs are becoming more computer-based, incorporating features such as soft controls and computerized procedures, touch-screen interfaces, sit-down workstations, and large-screen overview displays. As computer-based technologies are integrated into control rooms that were largely based on conventional technology, hybrid control rooms are created. The potential benefits of implementing digital technology include more efficient operations and maintenance, leading to improved power plant availability and safety through the avoidance of transients, forced outages, and unnecessary shutdowns. The potential benefits also include increased efficiency and power output as well as reduced operating costs. New digital systems provide the opportunity to give personnel information they did not have with conventional systems. The importance of these issues has led the IAEA to organize (in conjunction with AECL) an international forum for presentations and discussions on the potential benefits and challenges related to the integration of Analog and Digital Instrumentation and Control Systems in Hybrid Main Control Rooms. Many of these

On the analogy between thermally and irradiation induced creep

International Nuclear Information System (INIS)

Cozzarelli, F.A.; Huang, S.

1977-01-01

Employing an analogy between thermally induced and irradiation induced creep, physical arguments are used first to deduce a one-dimensional constitutive relation for metals under stress in a high temperature and high neutron flux field. This constitutive relation contains modified superposition integrals in which the temperature and flux dependence of the material parameters is included via the use of two reduced time scales; linear elastic, thermal expansion and swelling terms are also included. A systematic development based on thermodynamics, with the stress, temperature increment and defect density increment as independent variables in the Gibbs free energy, is then employed to obtain general three-dimensional memory integrals for strain; the entropy and coupled energy equation are also obtained. Modified superposition integrals similar to those previously obtained by physical argument are then obtained by substituting special functions into the results of the thermodynamic analysis, and the special case of an isotropic stress power law is examined in detail. (Auth.)

Synthetic Analogs of Phospholipid Metabolites as Antimalarials.

Science.gov (United States)

1979-07-01

phosphatidic acid analogs containing ether and phosphonate groups; completely non- hydrolyzable lecithin analogs containing phosphinate and ether groups...substance is a completely non- hydrolyzable analog of lecithin containing ether and phosphonate moieties instead of the normally labile carboxylic and...and also ant-i-phospholipase C (clostridial enzyme) activity. This substance Is a completely non- hydrolyzable analog of lecithin containing ether

FGF growth factor analogs

Science.gov (United States)

Zamora, Paul O [Gaithersburg, MD; Pena, Louis A [Poquott, NY; Lin, Xinhua [Plainview, NY; Takahashi, Kazuyuki [Germantown, MD

2012-07-24

The present invention provides a fibroblast growth factor heparin-binding analog of the formula: ##STR00001## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, X, Y and Z are as defined, pharmaceutical compositions, coating compositions and medical devices including the fibroblast growth factor heparin-binding analog of the foregoing formula, and methods and uses thereof.

A Transistor Sizing Tool for Optimization of Analog CMOS Circuits: TSOp

OpenAIRE

Y.C.Wong; Syafeeza A. R; N. A. Hamid

2015-01-01

Optimization of a circuit by transistor sizing is often a slow, tedious and iterative manual process which relies on designer intuition. It is highly desirable to automate the transistor sizing process towards being able to rapidly design high performance integrated circuit. Presented here is a simple but effective algorithm for automatically optimizing the circuit parameters by exploiting the relationships among the genetic algorithm's coefficient values derived from the analog circuit desig...

Molecular modeling of fentanyl analogs

Directory of Open Access Journals (Sweden)

LJILJANA DOSEN-MICOVIC

2004-11-01

Full Text Available Fentanyl is a highly potent and clinically widely used narcotic analgesic. A large number of its analogs have been synthesized, some of which (sufentanil and alfentanyl are also in clinical use. Theoretical studies, in recent years, afforded a better understanding of the structure-activity relationships of this class of opiates and allowed insight into the molecular mechanism of the interactions of fentanyl analogs with their receptors. An overview of the current computational techniques for modeling fentanyl analogs, their receptors and ligand-receptor interactions is presented in this paper.

Terrestrial Analogs to Mars

Science.gov (United States)

Farr, T. G.; Arcone, S.; Arvidson, R. W.; Baker, V.; Barlow, N. G.; Beaty, D.; Bell, M. S.; Blankenship, D. D.; Bridges, N.; Briggs, G.; Bulmer, M.; Carsey, F.; Clifford, S. M.; Craddock, R. A.; Dickerson, P. W.; Duxbury, N.; Galford, G. L.; Garvin, J.; Grant, J.; Green, J. R.; Gregg, T. K. P.; Guinness, E.; Hansen, V. L.; Hecht, M. H.; Holt, J.; Howard, A.; Keszthelyi, L. P.; Lee, P.; Lanagan, P. D.; Lentz, R. C. F.; Leverington, D. W.; Marinangeli, L.; Moersch, J. E.; Morris-Smith, P. A.; Mouginis-Mark, P.; Olhoeft, G. R.; Ori, G. G.; Paillou, P.; Reilly, J. F., II; Rice, J. W., Jr.; Robinson, C. A.; Sheridan, M.; Snook, K.; Thomson, B. J.; Watson, K.; Williams, K.; Yoshikawa, K.

2002-08-01

It is well recognized that interpretations of Mars must begin with the Earth as a reference. The most successful comparisons have focused on understanding geologic processes on the Earth well enough to extrapolate to Mars' environment. Several facets of terrestrial analog studies have been pursued and are continuing. These studies include field workshops, characterization of terrestrial analog sites, instrument tests, laboratory measurements (including analysis of Martian meteorites), and computer and laboratory modeling. The combination of all these activities allows scientists to constrain the processes operating in specific terrestrial environments and extrapolate how similar processes could affect Mars. The Terrestrial Analogs for Mars Community Panel has considered the following two key questions: (1) How do terrestrial analog studies tie in to the Mars Exploration Payload Assessment Group science questions about life, past climate, and geologic evolution of Mars, and (2) How can future instrumentation be used to address these questions. The panel has considered the issues of data collection, value of field workshops, data archiving, laboratory measurements and modeling, human exploration issues, association with other areas of solar system exploration, and education and public outreach activities.

Expert analogy use in a naturalistic setting

Science.gov (United States)

Kretz, Donald R.; Krawczyk, Daniel C.

2014-01-01

The use of analogy is an important component of human cognition. The type of analogy we produce and communicate depends heavily on a number of factors, such as the setting, the level of domain expertise present, and the speaker's goal or intent. In this observational study, we recorded economics experts during scientific discussion and examined the categorical distance and structural depth of the analogies they produced. We also sought to characterize the purpose of the analogies that were generated. Our results supported previous conclusions about the infrequency of superficial similarity in subject-generated analogs, but also showed that distance and depth characteristics were more evenly balanced than in previous observational studies. This finding was likely due to the nature of the goals of the participants, as well as the broader nature of their expertise. An analysis of analogical purpose indicated that the generation of concrete source examples of more general target concepts was most prevalent. We also noted frequent instances of analogies intended to form visual images of source concepts. Other common purposes for analogies were the addition of colorful speech, inclusion (i.e., subsumption) of a target into a source concept, or differentiation between source and target concepts. We found no association between depth and either of the other two characteristics, but our findings suggest a relationship between purpose and distance; i.e., that visual imagery typically entailed an outside-domain source whereas exemplification was most frequently accomplished using within-domain analogies. Overall, we observed a rich and diverse set of spontaneously produced analogical comparisons. The high degree of expertise within the observed group along with the richly comparative nature of the economics discipline likely contributed to this analogical abundance. PMID:25505437

Expert Analogy Use in a Naturalistic Setting

Directory of Open Access Journals (Sweden)

Donald R Kretz

2014-11-01

Full Text Available The use of analogy is an important component of human cognition. The type of analogy we produce and communicate depends heavily on a number of factors, such as the setting, the level of domain expertise present, and the speaker’s goal or intent. In this observational study, we recorded economics experts during scientific discussion and examined the categorical distance and structural depth of the analogies they produced. We also sought to characterize the purpose of the analogies that were generated. Our results supported previous conclusions about the infrequency of superficial similarity in subject-generated analogs, but also showed that distance and depth characteristics were more evenly balanced than in previous observational studies. This finding was likely due to the nature of the goals of the participants, as well as the broader nature of their expertise. An analysis of analogical purpose indicated that the generation of concrete source examples of more general target concepts was most prevalent. We also noted frequent instances of analogies intended to form visual images of source concepts. Other common purposes for analogies were the addition of colorful speech, inclusion (i.e., subsumption of a target into a source concept, or differentiation between source and target concepts. We found no association between depth and either of the other two characteristics, but our findings suggest a relationship between purpose and distance; i.e., that visual imagery typically entailed an outside-domain source whereas exemplification was most frequently accomplished using within-domain analogies. Overall, we observed a rich and diverse set of spontaneously produced analogical comparisons. The high degree of expertise within the observed group along with the richly comparative nature of the economics discipline likely contributed to this analogical abundance.

Intrinsic Hardware Evolution for the Design and Reconfiguration of Analog Speed Controllers for a DC Motor

Science.gov (United States)

Gwaltney, David A.; Ferguson, Michael I.

2003-01-01

Evolvable hardware provides the capability to evolve analog circuits to produce amplifier and filter functions. Conventional analog controller designs employ these same functions. Analog controllers for the control of the shaft speed of a DC motor are evolved on an evolvable hardware platform utilizing a second generation Field Programmable Transistor Array (FPTA2). The performance of an evolved controller is compared to that of a conventional proportional-integral (PI) controller. It is shown that hardware evolution is able to create a compact design that provides good performance, while using considerably less functional electronic components than the conventional design. Additionally, the use of hardware evolution to provide fault tolerance by reconfiguring the design is explored. Experimental results are presented showing that significant recovery of capability can be made in the face of damaging induced faults.

Using Visual Analogies To Teach Introductory Statistical Concepts

Directory of Open Access Journals (Sweden)

Jessica S. Ancker

2017-07-01

Full Text Available Introductory statistical concepts are some of the most challenging to convey in quantitative literacy courses. Analogies supplemented by visual illustrations can be highly effective teaching tools. This literature review shows that to exploit the power of analogies, teachers must select analogies familiar to the audience, explicitly link the analog with the target concept, and avert misconceptions by explaining where the analogy fails. We provide guidance for instructors and a series of visual analogies for use in teaching medical and health statistics.

The neuromechanism underlying verbal analogical reasoning of metaphorical relations: an event-related potentials study.

Science.gov (United States)

Zhao, Ming; Meng, Huishan; Xu, Zhiyuan; Du, Fenglei; Liu, Tao; Li, Yongxin; Chen, Feiyan

2011-11-24

Using event-related potentials (ERPs), this study investigated the neuromechanism underlying verbal analogical reasoning of two different metaphorical relations: attributive metaphor and relational metaphor. The analogical reasoning of attributive metaphor (AM-AR) involves a superficial similarity between analogues, while the analogical reasoning of relational metaphor (RM-AR) requires a structural similarity. Subjects were asked to judge whether one word pair was semantically analogous to another word pair. Results showed that the schema induction stage elicited a greater N400 component at the right anterior scalp for the AM-AR and RM-AR tasks, possibly attributable to semantic processing of metaphorical word pairs. The N400 was then followed by a widely distributed P300 and a late negative component (LNC1) at the left anterior scalp. The P300 was possibly related to the formation of a relational category, while the LNC1 was possibly related to the maintenance of a reasoning cue in working memory. The analogy mapping stage elicited broadly distributed N400 and LNC2, which might indicate the presence of semantic retrieval and analogical transfer. In the answer production stage, all conditions elicited the P2 component due to early stimulus encoding. The largest P2 amplitude was in the RM-AR task. The RM-AR elicited a larger LPC than did the AM-AR, even though the baseline correction was taken as a control for the differential P2 effect. The LPC effect might suggest that relational metaphors involved more integration processing than attributive metaphors. Copyright © 2011 Elsevier B.V. All rights reserved.

Lunar and Planetary Science XXXV: Mars: Remote Sensing and Terrestrial Analogs

Science.gov (United States)

2004-01-01

The session "Mars: Remote Sensing and Terrestrial Analogs" included the following:Physical Meaning of the Hapke Parameter for Macroscopic Roughness: Experimental Determination for Planetary Regolith Surface Analogs and Numerical Approach; Near-Infrared Spectra of Martian Pyroxene Separates: First Results from Mars Spectroscopy Consortium; Anomalous Spectra of High-Ca Pyroxenes: Correlation Between Ir and M ssbauer Patterns; THEMIS-IR Emissivity Spectrum of a Large Dark Streak near Olympus Mons; Geomorphologic/Thermophysical Mapping of the Athabasca Region, Mars, Using THEMIS Infrared Imaging; Mars Thermal Inertia from THEMIS Data; Multispectral Analysis Methods for Mapping Aqueous Mineral Depostis in Proposed Paleolake Basins on Mars Using THEMIS Data; Joint Analysis of Mars Odyssey THEMIS Visible and Infrared Images: A Magic Airbrush for Qualitative and Quantitative Morphology; Analysis of Mars Thermal Emission Spectrometer Data Using Large Mineral Reference Libraries ; Negative Abundance : A Problem in Compositional Modeling of Hyperspectral Images; Mars-LAB: First Remote Sensing Data of Mineralogy Exposed at Small Mars-Analog Craters, Nevada Test Site; A Tool for the 2003 Rover Mini-TES: Downwelling Radiance Compensation Using Integrated Line-Sight Sky Measurements; Learning About Mars Geology Using Thermal Infrared Spectral Imaging: Orbiter and Rover Perspectives; Classifying Terrestrial Volcanic Alteration Processes and Defining Alteration Processes they Represent on Mars; Cemented Volcanic Soils, Martian Spectra and Implications for the Martian Climate; Palagonitic Mars: A Basalt Centric View of Surface Composition and Aqueous Alteration; Combining a Non Linear Unmixing Model and the Tetracorder Algorithm: Application to the ISM Dataset; Spectral Reflectance Properties of Some Basaltic Weathering Products; Morphometric LIDAR Analysis of Amboy Crater, California: Application to MOLA Analysis of Analog Features on Mars; Airborne Radar Study of Soil Moisture at

The force of dissimilar analogies in bioethics.

Science.gov (United States)

Mertes, Heidi; Pennings, Guido

2011-04-01

Although analogical reasoning has long been a popular method of reasoning in bioethics, current literature does not sufficiently grasp its variety. We assert that the main shortcoming is the fact that an analogy's value is often judged on the extent of similarity between the source situation and the target situation, while in (bio)ethics, analogies are often used because of certain dissimilarities rather than in spite of them. We make a clear distinction between dissimilarities that aim to reinforce a similar approach in the source situation and the target situation and dissimilarities that aim to undermine or denounce a similar approach. The former kind of dissimilarity offers the analogy more normative force than if there were no dissimilarities present; this is often overlooked by authors who regard all relevant dissimilarities as detrimental to the analogy's strength. Another observation is that an evaluation of the normative force of an analogy cannot be made independently of moral principles or theories. Without these, one cannot select which elements in an analogy are morally relevant nor determine how they should be interpreted.

Anti-Plasmodium activity of ceramide analogs

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Gatt Shimon

2004-12-01

Full Text Available Abstract Background Sphingolipids are key molecules regulating many essential functions in eukaryotic cells and ceramide plays a central role in sphingolipid metabolism. A sphingolipid metabolism occurs in the intraerythrocytic stages of Plasmodium falciparum and is associated with essential biological processes. It constitutes an attractive and potential target for the development of new antimalarial drugs. Methods The anti-Plasmodium activity of a series of ceramide analogs containing different linkages (amide, methylene or thiourea linkages between the fatty acid part of ceramide and the sphingoid core was investigated in culture and compared to the sphingolipid analog PPMP (d,1-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol. This analog is known to inhibit the parasite sphingomyelin synthase activity and block parasite development by preventing the formation of the tubovesicular network that extends from the parasitophorous vacuole to the red cell membrane and delivers essential extracellular nutrients to the parasite. Results Analogs containing methylene linkage showed a considerably higher anti-Plasmodium activity (IC50 in the low nanomolar range than PPMP and their counterparts with a natural amide linkage (IC50 in the micromolar range. The methylene analogs blocked irreversibly P. falciparum development leading to parasite eradication in contrast to PPMP whose effect is cytostatic. A high sensitivity of action towards the parasite was observed when compared to their effect on the human MRC-5 cell growth. The toxicity towards parasites did not correlate with the inhibition by methylene analogs of the parasite sphingomyelin synthase activity and the tubovesicular network formation, indicating that this enzyme is not their primary target. Conclusions It has been shown that ceramide analogs were potent inhibitors of P. falciparum growth in culture. Interestingly, the nature of the linkage between the fatty acid part and the

The future of vitamin D analogs

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Carlien eLeyssens

2014-04-01

Full Text Available The active form of vitamin D3, 1,25-dihydroxyvitamin D3, is a major regulator of bone and calcium homeostasis. In addition, this hormone also inhibits the proliferation and stimulates the differentiation of normal as well as malignant cells. Supraphysiological doses of 1,25-dihydroxyvitamin D3 are required to reduce cancer cell proliferation. However, these doses will lead in vivo to calcemic side effects such as hypercalcemia and hypercalciuria. During the last 25 years, many structural analogs of 1,25-dihydroxyvitamin D3 have been synthesized by the introduction of chemical modifications in the A-ring, central CD-ring region or side chain of 1,25-dihydroxyvitamin D3 in the hope to find molecules with a clear dissociation between the beneficial antiproliferative effects and adverse calcemic side effects. One example of such an analog with a good dissociation ratio is calcipotriol (DaivonexR, which is clinically used to treat the hyperproliferative skin disease psoriasis. Other vitamin D analogs were clinically approved for the treatment of osteoporosis or secondary hyperparathyroidism. No vitamin D analog is currently used in the clinic for the treatment of cancer although several analogs have been shown to be potent drugs in animal models of cancer. Omics studies as well as in vitro cell biological experiments unraveled basic mechanisms involved in the antineoplastic effects of vitamin D and its analogs. 1,25-dihydroxyvitamin D3 and analogs act in a cell type- and tissue-specific manner. Moreover, a blockade in the transition of the G0/1 towards S phase of the cell cycle, induction of apoptosis, inhibition of migration and invasion of tumor cells together with effects on angiogenesis and inflammation have been implicated in the pleiotropic effects of 1,25-dihydroxyvitamin D3 and its analogs. In this review we will give an overview of the action of vitamin D analogs in tumor cells and look forward how these compounds could be introduced in the

Enhancing programming logic thinking using analogy mapping

Science.gov (United States)

Sukamto, R. A.; Megasari, R.

2018-05-01

Programming logic thinking is the most important competence for computer science students. However, programming is one of the difficult subject in computer science program. This paper reports our work about enhancing students' programming logic thinking using Analogy Mapping for basic programming subject. Analogy Mapping is a computer application which converts source code into analogies images. This research used time series evaluation and the result showed that Analogy Mapping can enhance students' programming logic thinking.

Gemini analogs of vitamin D.

Science.gov (United States)

Pazos, Gonzalo; Rivadulla, Marcos L; Pérez-García, Xenxo; Gandara, Zoila; Pérez, Manuel

2014-01-01

The Gemini analogs are the last significant contribution to the family of vitamin D derivatives in medicine, for the treatment of cancer. The first Gemini analog was characterized by two symmetric side chains at C-20. Following numerous modifications, the most active analog bears a C-23-triple bond, C-26, 27- hexafluoro substituents on one side chain and a terminal trideuteromethylhydroxy group on the other side chain. This progression was possible due to improvements in the synthetic methods for the preparation of these derivatives, which allowed for increasing molecular complexity and complete diastereoselective control at C-20 and the substituted sidechains.

A simple method to adapt time sampling of the analog signal

International Nuclear Information System (INIS)

Kalinin, Yu.G.; Martyanov, I.S.; Sadykov, Kh.; Zastrozhnova, N.N.

2004-01-01

In this paper we briefly describe the time sampling method, which is adapted to the speed of the signal change. Principally, this method is based on a simple idea--the combination of discrete integration with differentiation of the analog signal. This method can be used in nuclear electronics research into the characteristics of detectors and the shape of the pulse signal, pulse and transitive characteristics of inertial systems of processing of signals, etc

Children’s Failure in Analogical Reasoning Tasks: A Problem of Focus of Attention and Information Integration?

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Yannick Glady

2017-05-01

Full Text Available Children’s improved performance with age in analogy tasks has been explained by an increase in semantic knowledge of the items and the relations between them or by the development of an increased ability to inhibit irrelevant information. We tested the so-called “unbalanced attentional focus hypothesis” that claims that a failure to choose the “analogical” match can be the result of a difficulty to focus on all the relevant information available. Previous eye-tracking research has suggested, in analogies of the A:B::C:D format, that 5–6 year-olds organize their search around the C item. They focused significantly less than adults on the A:B pair, thereby hindering their discovering the relation(s between A and B. We hypothesized that inducing them to focus their attention on the A:B pair at the beginning of the trial would affect their performance. In Experiment 1, increasing children’s focus on the A:B pair did, indeed, lead to better performance. In contrast, in Experiment 2, focusing their attention on the A:B pair impaired performance when the most salient relation holding between A and B was, in fact, irrelevant for the analogy. By contrast, the obvious-but-irrelevant relation in the A:B pair had no negative effect on performance when no explicit A:B focusing was induced. These results are discussed in terms of the temporal organization of the task and availability of information, and of children’s difficulties to disengage from the main goal of the task, when necessary.

Children’s Failure in Analogical Reasoning Tasks: A Problem of Focus of Attention and Information Integration?

Science.gov (United States)

Glady, Yannick; French, Robert M.; Thibaut, Jean-Pierre

2017-01-01

Children’s improved performance with age in analogy tasks has been explained by an increase in semantic knowledge of the items and the relations between them or by the development of an increased ability to inhibit irrelevant information. We tested the so-called “unbalanced attentional focus hypothesis” that claims that a failure to choose the “analogical” match can be the result of a difficulty to focus on all the relevant information available. Previous eye-tracking research has suggested, in analogies of the A:B::C:D format, that 5–6 year-olds organize their search around the C item. They focused significantly less than adults on the A:B pair, thereby hindering their discovering the relation(s) between A and B. We hypothesized that inducing them to focus their attention on the A:B pair at the beginning of the trial would affect their performance. In Experiment 1, increasing children’s focus on the A:B pair did, indeed, lead to better performance. In contrast, in Experiment 2, focusing their attention on the A:B pair impaired performance when the most salient relation holding between A and B was, in fact, irrelevant for the analogy. By contrast, the obvious-but-irrelevant relation in the A:B pair had no negative effect on performance when no explicit A:B focusing was induced. These results are discussed in terms of the temporal organization of the task and availability of information, and of children’s difficulties to disengage from the main goal of the task, when necessary. PMID:28588516

A fast multichannel analog storage system

International Nuclear Information System (INIS)

Freytag, D.R.

1983-01-01

A Multichannel Analog Storage System based on a commercial 32-channel parallel in/serial out (PISO) analog shift register is described. The basic unit is a single width CAMAC module containing 512 analog cells and the associated logic for data storage and subsequent readout. At sampling rates of up to 30 MHz the signals are strobed directly into the PISO. At higher rates signals are strobed into a fast presampling stage and subsequently transferred in block form into an array of PISO's. Sampling rates of 300 MHz have been achieved with the present device and 1000 MHz are possible with improved signal drivers. The system is well suited for simultaneous handling of many signal channels with moderate numbers of samples in each channel. RMS noise over full scale signal has been measured as 1:3000 (approx. =11 bit). However, nonlinearities in the response and differences in sensitivity of the analog cells require an elaborate calibration system in order to realize 11 bit accuracy for the analog information

Atheism and Analogy: Aquinas Against the Atheists

OpenAIRE

Linford, Daniel J.

2014-01-01

In the 13th century, Thomas Aquinas developed two models for how humans may speak of God - either by the analogy of proportion or by the analogy of proportionality. Aquinas's doctrines initiated a theological debate concerning analogy that spanned several centuries. In the 18th century, there appeared two closely related arguments for atheism which both utilized analogy for their own purposes. In this thesis, I show that one argument, articulated by the French materialist Paul-Henri Thiry Bar...

Analog filters in nanometer CMOS

CERN Document Server

Uhrmann, Heimo; Zimmermann, Horst

2014-01-01

Starting from the basics of analog filters and the poor transistor characteristics in nanometer CMOS 10 high-performance analog filters developed by the authors in 120 nm and 65 nm CMOS are described extensively. Among them are gm-C filters, current-mode filters, and active filters for system-on-chip realization for Bluetooth, WCDMA, UWB, DVB-H, and LTE applications. For the active filters several operational amplifier designs are described. The book, furthermore, contains a review of the newest state of research on low-voltage low-power analog filters. To cover the topic of the book comprehensively, linearization issues and measurement methods for the characterization of advanced analog filters are introduced in addition. Numerous elaborate illustrations promote an easy comprehension. This book will be of value to engineers and researchers in industry as well as scientists and Ph.D students at universities. The book is also recommendable to graduate students specializing on nanoelectronics, microelectronics ...

Scientific Analogies and Their Use in Teaching Science

Science.gov (United States)

Kipnis, Nahum

Analogy in science knew its successes and failures, as illustrated by examples from the eighteenth-century physics. At times, some scientists abstained from using a certain analogy on the ground that it had not yet been demonstrated. Several false discoveries in the 18th and early 19th centuries appeared to support their caution. It is now clear that such a position reflected a methodological confusion that resulted from a failure to distinguish between particular and general analogies. Considering analogy as a hierarchical structure provides a new insight into "testing an analogy". While warning science teachers of dangers associated with use of analogy, historical cases and their analysis provided here may encourage them to use analogy more extensively while avoiding misconceptions. An argument is made that the history of science may be a better guide than philosophy of science and cognitive psychology when it concerns the role of analogy in science and in teaching science for understanding.

Method and apparatus for analog signal conditioner for high speed, digital x-ray spectrometer

International Nuclear Information System (INIS)

Warburton, W.K.; Hubbard, B.

1999-01-01

A signal processing system which accepts input from an x-ray detector-preamplifier and produces a signal of reduced dynamic range for subsequent analog-to-digital conversion is disclosed. The system conditions the input signal to reduce the number of bits required in the analog-to-digital converter by removing that part of the input signal which varies only slowly in time and retaining the amplitude of the pulses which carry information about the x-rays absorbed by the detector. The parameters controlling the signal conditioner's operation can be readily supplied in digital form, allowing it to be integrated into a feedback loop as part of a larger digital x-ray spectroscopy system. 13 figs

Drawing Analogies in Environmental Education

Science.gov (United States)

Affifi, Ramsey

2014-01-01

Reconsidering the origin, process, and outcomes of analogy-making suggests practices for environmental educators who strive to disengage humans from the isolating illusions of dichotomizing frameworks. We can view analogies as outcomes of developmental processes within which human subjectivity is but an element, threading our sense of self back…

A chopper-stabilized long pulse integrator with low drift

International Nuclear Information System (INIS)

Wei Yongqing; Xie Jikang; Wan Baonian; Shen Biao

2006-01-01

A chopper-stabilized integrator for tokamak with a digital signal processing unit to dynamically suppress the primary drift factors of analog integrator, has been designed. Long pulse integrations with low drift have been obtained with this apparatus in experiments. (authors)

How Four Scientists Integrate Thermodynamic and Kinetic Theory, Context, Analogies, and Methods in Protein-Folding and Dynamics Research: Implications for Biochemistry Instruction.

Science.gov (United States)

Jeffery, Kathleen A; Pelaez, Nancy; Anderson, Trevor R

2018-01-01

To keep biochemistry instruction current and relevant, it is crucial to expose students to cutting-edge scientific research and how experts reason about processes governed by thermodynamics and kinetics such as protein folding and dynamics. This study focuses on how experts explain their research into this topic with the intention of informing instruction. Previous research has modeled how expert biologists incorporate research methods, social or biological context, and analogies when they talk about their research on mechanisms. We used this model as a guiding framework to collect and analyze interview data from four experts. The similarities and differences that emerged from analysis indicate that all experts integrated theoretical knowledge with their research context, methods, and analogies when they explained how phenomena operate, in particular by mapping phenomena to mathematical models; they explored different processes depending on their explanatory aims, but readily transitioned between different perspectives and explanatory models; and they explained thermodynamic and kinetic concepts of relevance to protein folding in different ways that aligned with their particular research methods. We discuss how these findings have important implications for teaching and future educational research. © 2018 K. A. Jeffery et al. CBE—Life Sciences Education © 2018 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Conjecturing via Reconceived Classical Analogy

Science.gov (United States)

Lee, Kyeong-Hwa; Sriraman, Bharath

2011-01-01

Analogical reasoning is believed to be an efficient means of problem solving and construction of knowledge during the search for and the analysis of new mathematical objects. However, there is growing concern that despite everyday usage, learners are unable to transfer analogical reasoning to learning situations. This study aims at facilitating…

Integrating Gender and Group Differences into Bridging Strategy

Science.gov (United States)

Yilmaz, Serkan; Eryilmaz, Ali

2010-01-01

The main goal of this study was to integrate gender and group effect into bridging strategy in order to assess the effect of bridging analogy-based instruction on sophomore students' misconceptions in Newton's Third Law. Specifically, the authors developed and benefited from anchoring analogy diagnostic test to merge the effect of group and gender…

Effects of Analog-to-Digital Converter Nonlinearities on Radar Range-Doppler Maps

Energy Technology Data Exchange (ETDEWEB)

Doerry, Armin Walter [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Dubbert, Dale F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Tise, Bertice L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2014-07-01

Radar operation, particularly Ground Moving Target Indicator (GMTI) radar modes, are very sensitive to anomalous effects of system nonlinearities. These throw off harmonic spurs that are sometimes detected as false alarms. One significant source of nonlinear behavior is the Analog to Digital Converter (ADC). One measure of its undesired nonlinearity is its Integral Nonlinearity (INL) specification. We examine in this report the relationship of INL to GMTI performance.

Spectrometric analog-to-digital converter

International Nuclear Information System (INIS)

Ormandzhiev, S.I.; Jordanov, V.T.

1988-01-01

Converter of digit-by-digit counterbalancing with slipping dial with number of channels equal to total number of states of the main digital-to-analog converter of digit-by-digit counterbalancing systems is presented. Algorithm for selection of digital-to-analog converters, which must be used by means of computer is suggested

Relations as transformations: implications for analogical reasoning.

Science.gov (United States)

Leech, Robert; Mareschal, Denis; Cooper, Richard P

2007-07-01

We present two experiments assessing whether the size of a transformation instantiating a relation between two states of the world (e.g., shrinks) is a performance factor affecting analogical reasoning. The first experiment finds evidence of transformation size as a significant factor in adolescent analogical problem solving while the second experiment finds a similar effect on adult analogical reasoning using a markedly different analogical completion paradigm. The results are interpreted as providing evidence for the more general framework that cognitive representations of relations are best understood as mental transformations.

Fermilab accelerator control system: Analog monitoring facilities

International Nuclear Information System (INIS)

Seino, K.; Anderson, L.; Smedinghoff, J.

1987-10-01

Thousands of analog signals are monitored in different areas of the Fermilab accelerator complex. For general purposes, analog signals are sent over coaxial or twinaxial cables with varying lengths, collected at fan-in boxes and digitized with 12 bit multiplexed ADCs. For higher resolution requirements, analog signals are digitized at sources and are serially sent to the control system. This paper surveys ADC subsystems that are used with the accelerator control systems and discusses practical problems and solutions, and it describes how analog data are presented on the console system

Musik som analogi og metafor

DEFF Research Database (Denmark)

Bonde, Lars Ole

2014-01-01

Indeholder underkapitlerne: 2.5.1 Musik som analogi 2.5.2 Musik som metafor 2.5.3 Musikkens psykologiske funktioner - en taxonomi og metaforisk lytning til fire baroksatser......Indeholder underkapitlerne: 2.5.1 Musik som analogi 2.5.2 Musik som metafor 2.5.3 Musikkens psykologiske funktioner - en taxonomi og metaforisk lytning til fire baroksatser...

Integration of analog and digital instrumentation and control systems in hybrid control rooms

International Nuclear Information System (INIS)

2010-01-01

he IAEA's activities in the area of nuclear power plant operating performance and life cycle management are aimed at increasing Member State capabilities in utilizing good engineering and management practices as developed and transferred by the IAEA. In particular, the IAEA supports the improvement of nuclear power plant performance, plant life management, training, power uprating, operational license renewal, and the modernization of instrumentation and control (I and C) systems of plants. The issue of the integration of analog and digital I and C systems in hybrid control rooms was suggested by the IAEA Technical Working Group on Nuclear Power Plant Control and Instrumentation (TWG-NPPCI) at its meetings in 2003 and 2005. The subject was then approved by the IAEA and included in its work programmes for 2006-2009. The purpose of this report is to help nuclear utilities in planning control room and other human system interface (HSI) changes, making appropriate use of modern technologies. These technologies would aid in managing ageing and obsolescence, and facilitate improvements in plant performance and safety. This report covers a broad spectrum of potential changes to the control room ranging from the replacement of a few obsolete components with newer digital devices to a fully computerized control room. New digital technologies offer significant opportunities to improve access to and presentation of information to the user, e.g. operators, maintenance staff and management. However, this technology should be used prudently. In some cases, modernization is undertaken to resolve ageing and obsolescence or to meet regulatory requirements for license renewal. The integration of new technologies during main control room (MCR) modernizations should be performed cautiously and all affected aspects of plant maintenance, and operation should be carefully considered, paying particular attention to the human factors elements of these aspects. This report describes a

Towards a computational- and algorithmic-level account of concept blending using analogies and amalgams

Science.gov (United States)

Besold, Tarek R.; Kühnberger, Kai-Uwe; Plaza, Enric

2017-10-01

Concept blending - a cognitive process which allows for the combination of certain elements (and their relations) from originally distinct conceptual spaces into a new unified space combining these previously separate elements, and enables reasoning and inference over the combination - is taken as a key element of creative thought and combinatorial creativity. In this article, we summarise our work towards the development of a computational-level and algorithmic-level account of concept blending, combining approaches from computational analogy-making and case-based reasoning (CBR). We present the theoretical background, as well as an algorithmic proposal integrating higher-order anti-unification matching and generalisation from analogy with amalgams from CBR. The feasibility of the approach is then exemplified in two case studies.

A 6 device SOI new technology for mixed analog-digital and rad-hard applications

International Nuclear Information System (INIS)

Blanc, J.P.; Bonaime, J.; Delevoye, E.; Pontcharra, J. de; Gautier, J.; Truche, R.

1993-01-01

DMILL technology is being developed for very rad-hard analog-digital applications, such as space and military circuits or as electronics for the future generation of high energy collider (LHC, CERN, Geneva). Both CMOS and junction (JFET and bipolar) transistors are needed. A new process has been integrated, based on a 1.2μm thick silicon film on insulator (SIMOX plus epitaxy), a complete dielectric isolation and low temperature process. The mean feature is that six different components are fabricated on the same wafer, taking into account the 12 volts supply voltage constraint for some analog applications. The first electrical characteristics are presented in this paper. The optimization capabilities of such a hardened CBi-CJ-CMOS technology are discussed

Human Health Countermeasures - Partial-Gravity Analogs Workshop

Science.gov (United States)

Barr, Yael; Clement, Gilles; Norsk, Peter

2016-01-01

The experimental conditions that were deemed the most interesting by the HHC Element lead scientists are those permitting studies of the long-term effects of exposure to (a) chronic rotation when supine or in head down tilt (ground-based); and (b) long-radius centrifugation (space based). It is interesting to note that chronic ground based slow rotation room studies have not been performed since the 1960's, when the USA and USSR were investigating the potential use of AG for long-duration space missions. On the other hand, the other partial gravity analogs, i.e., parabolic flight, HUT, suspension, and short-radius centrifugation, have been regularly used in the last three decades (see review in Clément et al. 2015). Based on the workshop evaluations and the scores by the HHC scientific disciplines indicated in tables 3 and 4, simulation of partial G between 0 and 1 should be prioritized as follows: Priority 1. Chronic space-based partial-G analogs: a. Chronic space-based long-radius centrifugation. The ideal scenario would be chronic long-radius centrifugation of cells, animals and humans in a translational research approach - ideally beyond low earth orbit under deep space environmental effects and at various rotations - to obtain different G-effects. In this scenario, all physiological systems could be evaluated and the relationship between physiological response and G level established. This would be the most integrative way of defining, for the first time ever, G-thresholds for each physiological system. b. Chronic space-based centrifugation of animals. Chronic centrifugation of rodents at various G levels in space would allow for determination of AG thresholds of protection for each physiological system. In this case, all physiological systems will be of interest. Intermittent centrifugation will be of secondary interest. c. Chronic space-based centrifugation of cell cultures (RWV). Bioreactor studies of cells and cell cultures of various tissues at various G

NASA HRP Immunology Discipline - Use of Terrestrial Analogs

Science.gov (United States)

Crucian, Brian

2014-01-01

Due to the cost and operational constraints, as well as technical implementation limitations, it is desirous to perform relevant space physiology investigations first in terrestrial 'space analogs'. This is particularly true for initial investigations, which may then provide appropriate focus for subsequent flight investigations, or for mechanistic investigations that simply cannot be performed during spaceflight. Appropriate analog choice is extremely important. There are a wide variety of terrestrial space analogs, each relevant to a particular physiological discipline (or disciplines) and each with a particular fidelity (or lack thereof) to spaceflight, and each with unique operational constraints. The HRP Immunology Discipline is tasked with managing the HRP Risk concerning clinical risk for Astronaut crews related to spaceflight-associated immune dysregulation. Such dysregulation has been documented to occur during spaceflight, and found to persist for the duration of a 6-month ISS mission. Studies continue to characterize the onorbit phenomenon, but it generally consists of diminished immunocyte function, dysregulated cytokine profiles, and persistent herpesvirus reactivation. Causes are thought to synergistically include microgravity, psychological or physiological stress, radiation, and/or circadian misalignment. An appropriate terrestrial analog for immune dysregulation would replicate as many of these influences as possible. Such analogs may include clinostat or bioreactor cell culture (microgravity), hindlimb suspension (stress, fluid shifts, hypokinesis), or human deployment to remote or extreme environments (isolation, stress, circadian). Also, the laboratory setting may be used as an analog, or to augment analogs, such as sleep deprivation/misalignment or human centrifugation to replicate gravitational stress. As an appropriate example of a NASA Disciplines use of Terrestrial space analogs, this talk will discuss spaceflight associated immune

The Development of Analogical Reasoning Processes.

Science.gov (United States)

Sternberg, Robert J.; Rifkin, Bathsheva

1979-01-01

Two experiments were conducted to test the generalizability to children of a theory of analogical reasoning processes, originally proposed for adults, and to examine the development of analogical reasoning processes in terms of five proposed sources of cognitive development. (MP)

Command Interface ASIC - Analog Interface ASIC Chip Set

Science.gov (United States)

Ruiz, Baldes; Jaffe, Burton; Burke, Gary; Lung, Gerald; Pixler, Gregory; Plummer, Joe; Katanyoutanant,, Sunant; Whitaker, William

2003-01-01

A command interface application-specific integrated circuit (ASIC) and an analog interface ASIC have been developed as a chip set for remote actuation and monitoring of a collection of switches, which can be used to control generic loads, pyrotechnic devices, and valves in a high-radiation environment. The command interface ASIC (CIA) can be used alone or in combination with the analog interface ASIC (AIA). Designed primarily for incorporation into spacecraft control systems, they are also suitable for use in high-radiation terrestrial environments (e.g., in nuclear power plants and facilities that process radioactive materials). The primary role of the CIA within a spacecraft or other power system is to provide a reconfigurable means of regulating the power bus, actuating all valves, firing all pyrotechnic devices, and controlling the switching of power to all switchable loads. The CIA is a mixed-signal (analog and digital) ASIC that includes an embedded microcontroller with supporting fault-tolerant switch control and monitoring circuitry that is capable of connecting to a redundant set of interintegrated circuit (I(sup 2)C) buses. Commands and telemetry requests are communicated to the CIA. Adherence to the I(sup 2)C bus standard helps to reduce development costs by facilitating the use of previously developed, commercially available components. The AIA is a mixed-signal ASIC that includes the analog circuitry needed to connect the CIA to a custom higher powered version of the I(sup 2)C bus. The higher-powered version is designed to enable operation with bus cables longer than those contemplated in the I(sup 2)C standard. If there are multiple higher-power I(sup 2)C-like buses, then there must an AIA between the CIA and each such bus. The AIA includes two identical interface blocks: one for the side-A I(sup 2)C clock and data buses and the other for the side B buses. All the AIAs on each side are powered from a common power converter module (PCM). Sides A and B

Eksplorasi Desain Dasar (Nirmana melalui Kombinasi Media Grafis Analog dan Digital: Suatu Penelitian Kelas/Studio

Directory of Open Access Journals (Sweden)

Anita Rahardja

2013-10-01

Full Text Available This article is based on a research aiming to contextualize the fundamental principles of art and design to current setting in which analog media are no longer chosen as the ultimate hardware/tools. It is important considering digital hardware becomes more and more prevalent even preferred by students, whereas analog tools are getting harder to obtain, expensive and less ecological friendly. The goal of this research is to produce method analysis and the creation of two-dimensional basic design through digital media (Camera followed by conventional drawing tools, documented and conducted by the lecturers and the students. So far, almost 100% of the studies concerning basic design could only be found in foreign publications, with visual work examples that cannot be used freely in Indonesian local education due to copyright issue. Therefore, a literature study is conducted to examine the formal objects of this research which are the elements and fundamental principles in design, followed by ideation and visualization processes carried by the students in basic design classes through the semester. The visualization itself will integrate analog and digital media to generate the material objects of the research, which is a series of two dimensional design compositions. These compositions are then analyzed and classified to taxonomic category of fundamental principles of two-dimensional design as an integral part of teaching-learning process (self-evaluation class for future improvement. 

Computational approaches to analogical reasoning current trends

CERN Document Server

Richard, Gilles

2014-01-01

Analogical reasoning is known as a powerful mode for drawing plausible conclusions and solving problems. It has been the topic of a huge number of works by philosophers, anthropologists, linguists, psychologists, and computer scientists. As such, it has been early studied in artificial intelligence, with a particular renewal of interest in the last decade. The present volume provides a structured view of current research trends on computational approaches to analogical reasoning. It starts with an overview of the field, with an extensive bibliography. The 14 collected contributions cover a large scope of issues. First, the use of analogical proportions and analogies is explained and discussed in various natural language processing problems, as well as in automated deduction. Then, different formal frameworks for handling analogies are presented, dealing with case-based reasoning, heuristic-driven theory projection, commonsense reasoning about incomplete rule bases, logical proportions induced by similarity an...

Event-Based Computation of Motion Flow on a Neuromorphic Analog Neural Platform

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Massimiliano eGiulioni

2016-02-01

Full Text Available We demonstrate robust optical flow extraction with an analog neuromorphic multi-chip system. The task is performed by a feed-forward network of analog integrate-and-fire neurons whose inputs are provided by contrast-sensitive photoreceptors. Computation is supported by the precise time of spike emission and follows the basic theoretical principles presented in (Benosman et al. 2014: the extraction of the optical flow is based on time lag in the activation of nearby retinal neurons. The same basic principle is embedded in the architecture proposed by Barlow and Levick in 1965 to explain the spiking activity of the direction-selective ganglion cells in the rabbit's retina. Mimicking those cells our neuromorphic detectors encode the amplitude and the direction of the apparent visual motion in their output spiking pattern. We built a 3x3 test grid of independent detectors, each observing a different portion of the scene, so that our final output is a spike train encoding a 3x3 optical flow vector field. In this work we focus on the architectural aspects, and we demonstrate that a network of mismatched delicate analog elements can reliably extract the optical flow from a simple visual scene.

Crows spontaneously exhibit analogical reasoning.

Science.gov (United States)

Smirnova, Anna; Zorina, Zoya; Obozova, Tanya; Wasserman, Edward

2015-01-19

Analogical reasoning is vital to advanced cognition and behavioral adaptation. Many theorists deem analogical thinking to be uniquely human and to be foundational to categorization, creative problem solving, and scientific discovery. Comparative psychologists have long been interested in the species generality of analogical reasoning, but they initially found it difficult to obtain empirical support for such thinking in nonhuman animals (for pioneering efforts, see [2, 3]). Researchers have since mustered considerable evidence and argument that relational matching-to-sample (RMTS) effectively captures the essence of analogy, in which the relevant logical arguments are presented visually. In RMTS, choice of test pair BB would be correct if the sample pair were AA, whereas choice of test pair EF would be correct if the sample pair were CD. Critically, no items in the correct test pair physically match items in the sample pair, thus demanding that only relational sameness or differentness is available to support accurate choice responding. Initial evidence suggested that only humans and apes can successfully learn RMTS with pairs of sample and test items; however, monkeys have subsequently done so. Here, we report that crows too exhibit relational matching behavior. Even more importantly, crows spontaneously display relational responding without ever having been trained on RMTS; they had only been trained on identity matching-to-sample (IMTS). Such robust and uninstructed relational matching behavior represents the most convincing evidence yet of analogical reasoning in a nonprimate species, as apes alone have spontaneously exhibited RMTS behavior after only IMTS training. Copyright © 2015 Elsevier Ltd. All rights reserved.

Perceptions of Rebuttal Analogy: Politeness and Implications for Persuasion.

Science.gov (United States)

Whaley, Bryan B.

1997-01-01

States that recent theorizing about the role of analogy in persuasion suggests that "rebuttal" analogy addresses two communicative functions by serving as argument and a method of social attack. Examines message receivers' perceptions of rebuttal analogy and rebuttal analogy users. Finds that participants perceived the communicator using…

Elucidating the neurotoxic effects of MDMA and its analogs.

Science.gov (United States)

Karuppagounder, Senthilkumar S; Bhattacharya, Dwipayan; Ahuja, Manuj; Suppiramaniam, Vishnu; Deruiter, Jack; Clark, Randall; Dhanasekaran, Muralikrishnan

2014-04-17

There is a rapid increase in the use of methylenedioxymethamphetamine (MDMA) and its structural congeners/analogs globally. MDMA and MDMA-analogs have been synthesized illegally in furtive dwellings and are abused due to its addictive potential. Furthermore, MDMA and MDMA-analogs have shown to have induced several adverse effects. Hence, understanding the mechanisms mediating this neurotoxic insult of MDMA-analogs is of immense importance for the public health in the world. We synthesized and investigated the neurotoxic effects of MDMA and its analogs [4-methylenedioxyamphetamine (MDA), 2, 6-methylenedioxyamphetamine (MDMA), and N-ethyl-3, 4-methylenedioxyamphetamine (MDEA)]. The stimulatory or the dopaminergic agonist effects of MDMA and MDMA-analogs were elucidated using the established 6-hydroxydopamine lesioned animal model. Additionally, we also investigated the neurotoxic mechanisms of MDMA and MDMA-analogs on mitochondrial complex-I activity and reactive oxygen species generation. MDMA and MDMA-analogs exhibited stimulatory activity as compared to amphetamines and also induced several behavioral changes in the rodents. MDMA and MDMA-analogs enhanced the reactive oxygen generation and inhibited mitochondrial complex-I activity which can lead to neurodegeneration. Hence the mechanism of neurotoxicity, MDMA and MDMA-analogs can enhance the release of monoamines, alter the monoaminergic neurotransmission, and augment oxidative stress and mitochondrial abnormalities leading to neurotoxicity. Thus, our study will help in developing effective pharmacological and therapeutic approaches for the treatment of MDMA and MDMA-analog abuse. Copyright © 2014 Elsevier Inc. All rights reserved.

Ultra low-power biomedical signal processing: An analog wavelet filter approach for pacemakers

OpenAIRE

Pavlík Haddad, S.A.

2006-01-01

The purpose of this thesis is to describe novel signal processing methodologies and analog integrated circuit techniques for low-power biomedical systems. Physiological signals, such as the electrocardiogram (ECG), the electroencephalogram (EEG) and the electromyogram (EMG) are mostly non-stationary. The main difficulty in dealing with biomedical signal processing is that the information of interest is often a combination of features that are well localized temporally (e.g., spikes) and other...

Learning Plate Tectonics Using a Pre-Analogy Step

Science.gov (United States)

Glesener, G. B.; Sandoval, W. A.

2011-12-01

Previous research has shown that children tend to demonstrate lower performance on analogical reasoning tasks at a causal relations level compared to most adults (Gentner & Toupin, 1986). This tendency is an obstacle that geoscience educators must overcome because of the high frequency of analogies used in geoscience pedagogy. In particular, analog models are used to convey complex systems of non-everyday/non-observable events found in nature, such as plate tectonics. Key factors in successful analogical reasoning that have been suggested by researchers include knowledge of the causal relations in the base analog (Brown & Kane, 1988; Gentner, 1988; Gentner & Toupin, 1986), and development of learning strategies and metaconceptual competence(Brown & Kane, 1988). External factors, such as guiding cues and hints have been useful cognitive supports that help students reason through analogical problems (Gick & Holyoak, 1980). Cognitive supports have been seen by researchers to decrease processing demands on retrieval and working memory (Richland, Zur, & Holyoak, 2007). We observed third and fourth graders learning about plate tectonics beginning with a pre-analogy step-a cognitive support activity a student can do before working with an analogy to understand the target. This activity was designed to aid students in developing their understanding of object attributes and relations within an analog model so that more focus can be placed on mapping the corresponding higher-order relations between the base and target. Students learned targeted concepts of plate tectonics, as measured by pre to post gains on items adapted from the Geosciences Concept Inventory. Analyses of classroom interaction showed that students used the object attributes and higher-order relations highlighted in the pre-analogy activity as resources to reason about plate boundaries and plate movement during earthquakes.

Natural analogs for Yucca Mountain

International Nuclear Information System (INIS)

Murphy, W.M.

1995-01-01

High-level radioactive waste in the US, spent fuels from commercial reactors and nuclear materials generated by defense activities, will remain potentially hazardous for thousands of years. Demonstrable long-term stability of certain geologic and geochemical systems motivates and sustains the concept that high-level waste can be safely isolated in geologic repositories for requisite periods of time. Each geologic repository is unique in its properties and performance with reguard to isolation of nuclear wastes. Studies of processes analogous to waste-form alteration and radioelement transport in environments analogous to Yucca Mountain are being conducted at two sites, described in this article to illustrate uses of natural analog data: the Nopal I uranium deposit in the Sierra Pena Blanca, Mexico, and the Akrotiri archaeological site on the island of Santorini, Greece

Analogy-Enhanced Instruction: Effects on Reasoning Skills in Science

Science.gov (United States)

Remigio, Krisette B.; Yangco, Rosanelia T.; Espinosa, Allen A.

2014-01-01

The study examined the reasoning skills of first year high school students after learning general science concepts through analogies. Two intact heterogeneous sections were randomly assigned to Analogy-Enhanced Instruction (AEI) group and Non Analogy-Enhanced (NAEI) group. Various analogies were incorporated in the lessons of the AEI group for…

Uncertainty estimation of non-ideal analog switches using programmable Josephson voltage standards for mutual inductance measurement in the joule balance

International Nuclear Information System (INIS)

Wang, Gang; Zhang, Zhonghua; Li, Zhengkun; Xu, Jinxin; You, Qiang

2016-01-01

Measurement of the mutual inductance is one of the key techniques in the joule balance to determine the Planck constant h, where a standard-square-wave compensation method was proposed to accurately measure the dc value of the mutual inductance. With this method, analog switches are used to compose an analog-switch signal generator to synthesize the excitation and compensation voltages. However, the accuracy of the compensation voltage is influenced by the non-ideal behaviors of analog-switches. In this paper, the effect from these non-ideal switches is analyzed in detail and evaluated with the equivalent circuits. A programmable Josephson voltage standard (PJVS) is used to generate a reference compensation voltage to measure the time integration of the voltage waveform generated by the analog-switch signal generator. Moreover, the effect is also evaluated experimentally by comparing the difference between the mutual inductance measured with the analog-switch signal generator and the value determined by the PJVS-analog-switch generator alternately in the same mutual inductance measurement system. The result shows that the impact of analog switches is 1.97  ×  10 −7 with an uncertainty of 1.83  ×  10 −7 (k  =  1) and confirms that the analog switch method can be used regularly instead of the PJVS in the mutual inductance measurement for the joule balance experiment. (paper)

Epistemology of analogy: Knowledge, society and expression

Directory of Open Access Journals (Sweden)

Mauricio Beuchot

2017-06-01

Full Text Available In this article we expose the bases of analog epistemology. This theory of knowledge is between an extreme subjectivism and an extreme objectivism. Analog hermeneutics is a realistic hermeneutics. She seeks the truth, but incorporates the meaning and emotion. We have separated the reason from the experience, the praxis theory, the mind or the soul of the body. We have to get them back together, if we do not get lost in the rational (which says little of the human being, or we lose ourselves in the emotional (without logical consistency. The analogical hermeneutic realism is able, thanks to the analogy itself, to mediate in this way of union.

Integration of 128 channels for monitoring, acquisition and control with existing LHCD DAC system

International Nuclear Information System (INIS)

Joshi, Ramesh; Virani, Chetan; Wadhwani, Archana; Sharma, P.K.

2015-01-01

Lower Hybrid Current Drive (LHCD) data acquisition system needs to be upgraded for additional channel requirement. The existing VME based DAC has been used since long with 32 analog input channels for data monitoring and control. Additional 128 channels require integrating with existing DAC. There are four layers of waveguides which deliver final output power into tokamak. Each layer requires 32 channels for power measurement. For the same requirement 128 analog input channels have been integrated with the help of carrier board and IP modules. Acromag IP330 modules have been procured and finally integrated with additional carrier board with existing VME hardware. Each module provides 32 analog input channels. Device driver has been developed for each module and integrated with existing program. LHCD DAC system has been upgraded with additional 128 channels requirement. It has been successfully testing with recent SST-1 campaign. (author)

An Analog Correlator for Ultra-Wideband Receivers

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Tu Chunjiang

2005-01-01

Full Text Available We present a new analog circuit exhibiting high bandwidth and low distortion, specially designed for signal correlation in an ultra-wideband receiver front end. The ultra-wideband short impulse signals are correlated with a local pulse template by the correlator. A comparator then samples the output for signal detection. A typical Gilbert mixer core is adopted for multiplication of broadband signals up to . As a result of synchronization of the received signal and the local template, the output voltage level after integration and sampling can reach up to , which is sufficient for detection by the comparator. The circuit dissipates about from double voltage supplies of and using SiGe BiCMOS technology. Simulation results are presented to show the feasibility of this circuit design for use in ultra-wideband receivers.

Analog elements for transuranic chemistries

International Nuclear Information System (INIS)

Weimer, W.C.

1982-01-01

The analytical technique for measuring trace concentrations of the analog rare earth elements has been refined for optimal detection. The technique has been used to determine the rare earth concentrations in a series of geological and biological materials, including samples harvested from controlled lysimeter investigations. These studies have demonstrated that any of the trivalent rare earth elements may be used as analog elements for the trivalent transuranics, americium and curium

Insulin analogs with improved pharmacokinetic profiles.

Science.gov (United States)

Brange; Vølund

1999-02-01

The aim of insulin replacement therapy is to normalize blood glucose in order to reduce the complications of diabetes. The pharmacokinetics of the traditional insulin preparations, however, do not match the profiles of physiological insulin secretion. The introduction of the rDNA technology 20 years ago opened new ways to create insulin analogs with altered properties. Fast-acting analogs are based on the idea that an insulin with less tendency to self-association than human insulin would be more readily absorbed into the systemic circulation. Protracted-acting analogs have been created to mimic the slow, steady rate of insulin secretion in the fasting state. The present paper provides a historical review of the efforts to change the physicochemical and pharmacological properties of insulin in order to improve insulin therapy. The available clinical studies of the new insulins are surveyed and show, together with modeling results, that new strategies for optimal basal-bolus treatment are required for utilization of the new fast-acting analogs.

Los pasiegos. La analogía salvaje y lo salvaje de la analogía

Directory of Open Access Journals (Sweden)

JAIME DE LA CALLE VALVERDE

2007-01-01

-entendiendo salvaje como un pensamiento humano prístino-: por un lado en sus relaciones con el racionalismo (¿emerge la analogía desde el racionalismo?, ¿qué relación guarda con éste?, ¿su nacimiento es resultado de una función «natural»? y por otro sobre la naturaleza social de lo salvaje a partir de las bases sociales que lo producen. Es decir, se rastrea lo que de salvaje tiene la analogía, si la analogía es o no una función ahistórica y asocial del intelecto humano. No se examina todo el complejo analógico de los pasiegos, únicamente aquél que establece relaciones homólogas entre las vacas y el entorno.

How the creative use of analogies can shape medical practice.

Science.gov (United States)

Prasad, G V Ramesh

2015-06-01

Analogical reasoning is central to medical progress, and is either creative or conservative. According to Hofmann et al., conservative analogy relates concepts from old technology to new technologies with emphasis on preservation of comprehension and conduct. Creative analogy however brings new understanding to new technology, brings similarities existing in the source domain to a target domain where they previously had no bearing, and imports something entirely different from the content of the analogy itself. I defend the claim that while conservative analogies are useful by virtue of being comfortable to use from familiarity and experience, and are more easily accepted by society, they only lead to incremental advances in medicine. However, creative analogies are more exciting and productive because they generate previously unexpected associations across widely separated domains, emphasize relations over physical similarities, and structure over superficiality. I use kidney transplantation and anti-rejection medication development as an exemplar of analogical reasoning used to improve medical practice. Anti-rejection medication has not helped highly sensitized patients because of their propensity to rejecting most organs. I outline how conservative analogical reasoning led to anti-rejection medication development, but creative analogical reasoning helped highly sensitized and blood type incompatible patients through domino transplants, by which they obtain a kidney to which they are not sensitized. Creative analogical reasoning is more likely than conservative analogical reasoning to lead to revolutionary progress. While these analogies overlap and creative analogies eventually become conservative, progress is best facilitated by combining conservative and creative analogical reasoning. © 2015 John Wiley & Sons, Ltd.

SOI Fully complementary BI-JFET-MOS technology for analog-digital applications with vertical BJT's

International Nuclear Information System (INIS)

Delevoye, E.; Blanc, J.P.; Bonaime, J.; Pontcharra, J. de; Gautier, J.; Martin, F.; Truche, R.

1993-01-01

A silicon-on-insulator, fully complementary, Bi-JFET-MOS technology has been developed for realizing multi-megarad hardened mixed analog-digital circuits. The six different active components plus resistors and capacitors have been successfully integrated in a 25-mask process using SIMOX substrate and 1 μm thick epitaxial layer. Different constraints such as device compatibility, complexity not higher than BiCMOS technology and breakdown voltages suitable for analog applications have been considered. Several process splits have been realized and all the characteristics presented here have been measured on the same split. P + gate is used for PMOS transistor to get N and PMOST symmetrical characteristics. Both NPN and PNP vertical bipolar transistors with poly-emitters show f T > 5 GHz. 2-separated gate JFET's need no additional mask. (authors). 9 figs., 1 tab

Analogs for transuranic elements

International Nuclear Information System (INIS)

Weimer, W.C.; Laul, J.C.; Kutt, J.C.

1981-01-01

A combined theoretical and experimental approach is being used to estimate the long-term environmental and biogeochemical behaviors of selected transuranic elements. The objective of this research is to estimate the effect that long-term (hundreds of years) environmental weathering has on the behavior of the transuranic elements americium and curium. This is achieved by investigating the actual behavior of naturally occurring rare earth elements, especially neodymium, that serve as transuranic analogs. Determination of the analog element behavior provides data that can be used to estimate the ultimate availability to man of transuranic materials released into the environment

Bayesian analogy with relational transformations.

Science.gov (United States)

Lu, Hongjing; Chen, Dawn; Holyoak, Keith J

2012-07-01

How can humans acquire relational representations that enable analogical inference and other forms of high-level reasoning? Using comparative relations as a model domain, we explore the possibility that bottom-up learning mechanisms applied to objects coded as feature vectors can yield representations of relations sufficient to solve analogy problems. We introduce Bayesian analogy with relational transformations (BART) and apply the model to the task of learning first-order comparative relations (e.g., larger, smaller, fiercer, meeker) from a set of animal pairs. Inputs are coded by vectors of continuous-valued features, based either on human magnitude ratings, normed feature ratings (De Deyne et al., 2008), or outputs of the topics model (Griffiths, Steyvers, & Tenenbaum, 2007). Bootstrapping from empirical priors, the model is able to induce first-order relations represented as probabilistic weight distributions, even when given positive examples only. These learned representations allow classification of novel instantiations of the relations and yield a symbolic distance effect of the sort obtained with both humans and other primates. BART then transforms its learned weight distributions by importance-guided mapping, thereby placing distinct dimensions into correspondence. These transformed representations allow BART to reliably solve 4-term analogies (e.g., larger:smaller::fiercer:meeker), a type of reasoning that is arguably specific to humans. Our results provide a proof-of-concept that structured analogies can be solved with representations induced from unstructured feature vectors by mechanisms that operate in a largely bottom-up fashion. We discuss potential implications for algorithmic and neural models of relational thinking, as well as for the evolution of abstract thought. Copyright 2012 APA, all rights reserved.

A Coral Reef as an Analogical Model to Promote Collaborative Learning on Cultural & Ethnic Diversity in Science

Science.gov (United States)

Yost, Robert W.; Gonzalez, Edward L. F.

2008-01-01

Analogical reasoning is integral to everyday living. The diversity associated with a coral reef provides a familiar model for initiating discussions focusing on cultural diversity and gender of past and present scientists with non-western science endeavors. These concepts are strengthened through the use of scientific biographical and historical…

Analogical reasoning for reliability analysis based on generic data

Energy Technology Data Exchange (ETDEWEB)

Kozin, Igor O

1996-10-01

The paper suggests using the systemic concept 'analogy' for the foundation of an approach to analyze system reliability on the basis of generic data, describing the method of structuring the set that defines analogical models, an approach of transition from the analogical model to a reliability model and a way of obtaining reliability intervals of analogous objects.

Analogical reasoning for reliability analysis based on generic data

International Nuclear Information System (INIS)

Kozin, Igor O.

1996-01-01

The paper suggests using the systemic concept 'analogy' for the foundation of an approach to analyze system reliability on the basis of generic data, describing the method of structuring the set that defines analogical models, an approach of transition from the analogical model to a reliability model and a way of obtaining reliability intervals of analogous objects

Low-voltage analog front-end processor design for ISFET-based sensor and H+ sensing applications

Science.gov (United States)

Chung, Wen-Yaw; Yang, Chung-Huang; Peng, Kang-Chu; Yeh, M. H.

2003-04-01

This paper presents a modular-based low-voltage analog-front-end processor design in a 0.5mm double-poly double-metal CMOS technology for Ion Sensitive Field Effect Transistor (ISFET)-based sensor and H+ sensing applications. To meet the potentiometric response of the ISFET that is proportional to various H+ concentrations, the constant-voltage and constant current (CVCS) testing configuration has been used. Low-voltage design skills such as bulk-driven input pair, folded-cascode amplifier, bootstrap switch control circuits have been designed and integrated for 1.5V supply and nearly rail-to-rail analog to digital signal processing. Core modules consist of an 8-bit two-step analog-digital converter and bulk-driven pre-amplifiers have been developed in this research. The experimental results show that the proposed circuitry has an acceptable linearity to 0.1 pH-H+ sensing conversions with the buffer solution in the range of pH2 to pH12. The processor has a potential usage in battery-operated and portable healthcare devices and environmental monitoring applications.

An updated program-controlled analog processor, model AP-006, for semiconductor detector spectrometers

International Nuclear Information System (INIS)

Shkola, N.F.; Shevchenko, Yu.A.

1989-01-01

An analog processor, model AP-006, is reported. The processor is a development of a series of spectrometric units based on a shaper of the type 'DL dif +TVS+gated ideal integrator'. Structural and circuits design features are described. The results of testing the processor in a setup with a Si(Li) detecting unit over an input count-rate range of up to 5x10 5 cps are presented. Processor applications are illustrated. (orig.)

Analogical Matrices in Young Children and Students with Intellectual Disability: Reasoning by Analogy or Reasoning by Association?

Science.gov (United States)

Denaes, Caroline

2012-01-01

Background: Analogical reasoning (AR) is renowned for being a complex activity. Young children tend to reason by association, rather by analogy, and people with intellectual disability present problems of memorization. Both these populations usually show low performances in AR. The present author investigated whether familiar material and external…

Neurotoxic Alkaloids: Saxitoxin and Its Analogs

Directory of Open Access Journals (Sweden)

Troco K. Mihali

2010-07-01

Full Text Available Saxitoxin (STX and its 57 analogs are a broad group of natural neurotoxic alkaloids, commonly known as the paralytic shellfish toxins (PSTs. PSTs are the causative agents of paralytic shellfish poisoning (PSP and are mostly associated with marine dinoflagellates (eukaryotes and freshwater cyanobacteria (prokaryotes, which form extensive blooms around the world. PST producing dinoflagellates belong to the genera Alexandrium, Gymnodinium and Pyrodinium whilst production has been identified in several cyanobacterial genera including Anabaena, Cylindrospermopsis, Aphanizomenon Planktothrix and Lyngbya. STX and its analogs can be structurally classified into several classes such as non-sulfated, mono-sulfated, di-sulfated, decarbamoylated and the recently discovered hydrophobic analogs—each with varying levels of toxicity. Biotransformation of the PSTs into other PST analogs has been identified within marine invertebrates, humans and bacteria. An improved understanding of PST transformation into less toxic analogs and degradation, both chemically or enzymatically, will be important for the development of methods for the detoxification of contaminated water supplies and of shellfish destined for consumption. Some PSTs also have demonstrated pharmaceutical potential as a long-term anesthetic in the treatment of anal fissures and for chronic tension-type headache. The recent elucidation of the saxitoxin biosynthetic gene cluster in cyanobacteria and the identification of new PST analogs will present opportunities to further explore the pharmaceutical potential of these intriguing alkaloids.

A hierarchical spatiotemporal analog forecasting model for count data.

Science.gov (United States)

McDermott, Patrick L; Wikle, Christopher K; Millspaugh, Joshua

2018-01-01

Analog forecasting is a mechanism-free nonlinear method that forecasts a system forward in time by examining how past states deemed similar to the current state moved forward. Previous applications of analog forecasting has been successful at producing robust forecasts for a variety of ecological and physical processes, but it has typically been presented in an empirical or heuristic procedure, rather than as a formal statistical model. The methodology presented here extends the model-based analog method of McDermott and Wikle (Environmetrics, 27, 2016, 70) by placing analog forecasting within a fully hierarchical statistical framework that can accommodate count observations. Using a Bayesian approach, the hierarchical analog model is able to quantify rigorously the uncertainty associated with forecasts. Forecasting waterfowl settling patterns in the northwestern United States and Canada is conducted by applying the hierarchical analog model to a breeding population survey dataset. Sea surface temperature (SST) in the Pacific Ocean is used to help identify potential analogs for the waterfowl settling patterns.

Molecular interactions between (--epigallocatechin gallate analogs and pancreatic lipase.

Directory of Open Access Journals (Sweden)

Shihui Wang

Full Text Available The molecular interactions between pancreatic lipase (PL and four tea polyphenols (EGCG analogs, like (--epigallocatechin gallate (EGCG, (--gallocatechin gallate (GCG, (--epicatechin gallate (ECG, and (--epigallocatechin (EC, were studied from PL activity, conformation, kinetics and thermodynamics. It was observed that EGCG analogs inhibited PL activity, and their inhibitory rates decreased by the order of EGCG>GCG>ECG>EC. PL activity at first decreased rapidly and then slowly with the increase of EGCG analogs concentrations. α-Helix content of PL secondary structure decreased dependent on EGCG analogs concentration by the order of EGCG>GCG>ECG>EC. EGCG, ECG, and EC could quench PL fluorescence both dynamically and statically, while GCG only quenched statically. EGCG analogs would induce PL self-assembly into complexes and the hydrodynamic radii of the complexes possessed a close relationship with the inhibitory rates. Kinetics analysis showed that EGCG analogs non-competitively inhibited PL activity and did not bind to PL catalytic site. DSC measurement revealed that EGCG analogs decreased the transition midpoint temperature of PL enzyme, suggesting that these compounds reduced PL enzyme thermostability. In vitro renaturation through urea solution indicated that interactions between PL and EGCG analogs were weak and non-covalent.

Functional DNA: Teaching Infinite Series through Genetic Analogy

Science.gov (United States)

Kowalski, R. Travis

2011-01-01

This article presents an extended analogy that connects infinite sequences and series to the science of genetics, by identifying power series as "DNA for a function." This analogy allows standard topics such as convergence tests or Taylor approximations to be recast in a "forensic" light as mathematical analogs of genetic concepts such as DNA…

Evaluation and comparison of bisphenol A analog activity ...

Science.gov (United States)

Bisphenol A (BPA) is used in consumer products and industrial applications, primarily in plastics, and has been detected in the environment, human urine, blood, and breast milk. Mainly studied as an endocrine disruptor, other toxicities, including obesity, metabolic conditions such as diabetes, and neurodevelopmental effects have also been associated with exposure to BPA, indicating that its effects may not be limited to estrogenicity. In addition, a number of BPA analogs are in use and may exhibit other additional toxicities. To address these unknowns, we examined the bioactivity of 21 BPA analogs across a selection of ToxCast/Tox21 assays grouped by 7 gene sets including estrogen receptor (ER), androgen receptor (AR), thyroid receptor (TR), peroxisome proliferator-activated receptor (PPAR), pregnane x receptor (PXR), aromatase (AROM), and aryl hydrocarbon receptor (AHR). The most active compounds were bisphenol AF (BPAF) (ER, AR, AROM, AHR), bisphenol A glycidyl methacrylate (TR), 3,3’,5,5’-tetrabromobisphenol A (PPAR) and bisphenol B (BPB) (PXR). We used these data to produce toxicological prioritization index (ToxPi) scores and images to integrate and visually compare the toxicity profiles across all gene sets. The compounds with highest ToxPi scores were BPAF, BPA and BPB. We also mapped the intended gene targets for all ToxCast assays to their associated KEGG BRITE protein families in order to characterize their toxicity profiles on a broader spectr

Analog techniques in CEBAF's RF control system

International Nuclear Information System (INIS)

Hovater, C.; Fugitt, J.

1989-01-01

Recent developments in high-speed analog technology have progressed into the areas of traditional RF technology. Diode related devices are being replaced by analog IC's in the CEBAF RF control system. Complex phase modulators and attenuators have been successfully tested at 70 MHz. They have three advantages over existing technology: lower cost, less temperature sensitivity, and more linearity. RF signal conditioning components and how to implement the new analog IC's will be covered in this paper. 4 refs., 5 figs

Analog techniques in CEBAF'S RF control system

International Nuclear Information System (INIS)

Hovater, C.; Fugitt, J.

1989-01-01

Recent developments in high-speed analog technology have progressed into the areas of traditional rf technology. Diode-related devices are being replaced by analog IC's in the CEBAF rf control system. Complex phase modulators and attenuators have been successfully tested at 70 MHz. They have three advantages over existing technology: lower cost, less temperature sensitivity, and more linearity. Rf signal conditioning components and how to implement the new analog IC's will be covered in this paper. 4 refs., 5 figs

Forecasting telecommunication new service demand by analogy method and combined forecast

Directory of Open Access Journals (Sweden)

Lin Feng-Jenq

2005-01-01

Full Text Available In the modeling forecast field, we are usually faced with the more difficult problems of forecasting market demand for a new service or product. A new service or product is defined as that there is absence of historical data in this new market. We hardly use models to execute the forecasting work directly. In the Taiwan telecommunication industry, after liberalization in 1996, there are many new services opened continually. For optimal investment, it is necessary that the operators, who have been granted the concessions and licenses, forecast this new service within their planning process. Though there are some methods to solve or avoid this predicament, in this paper, we will propose one forecasting procedure that integrates the concept of analogy method and the idea of combined forecast to generate new service forecast. In view of the above, the first half of this paper describes the procedure of analogy method and the approach of combined forecast, and the second half provides the case of forecasting low-tier phone demand in Taiwan to illustrate this procedure's feasibility.

Benefit of Analog, Programmable and Digital Hearing Aids

Directory of Open Access Journals (Sweden)

Jamileh Fatahi

2006-12-01

Full Text Available Background and Aims: As the hearing aid technology progressively promotes toward replacing analog hearing aids with digital and programmable ones, comparison of the patient satisfaction of those kinds of hearing aids by means of a valuable tool seems so necessary. So, the aim of this study was to compare self-reported benefit of analog, digitally controlled programmable and digital hearing aids for reducing disability caused by hearing impairment in mild to severe sensorineural hearing impaired persons. Materials and Methods: This cross-sectional study was performed on 90 persons with mild to severe sensorineural hearing loss dividing into three groups: 43 subjects were fitted with digital, 15 with programmable, 32 with analog hearing aids. After pure tone audiometry, Abbreviated profile of hearing aid benefit (APHAB was completed before and one month after using hearing aids to determine the benefit of them. Results: Global APHAB mean scores for digital, programmable and analog hearing aids were 49.05, 33.19 and 39.53, respectively. Ease of Communication subscale mean scores were 53.46 for digitals, 37.66 for programmables and 39.09 for analogs. Background noise subscale mean scores for digital programmable and analog hearing aids were 46.36, 25.53 and 35.31, respectively. Global and also both subscale mean scores showed significant difference between digital hearing aids and programmable and analog ones. There was no significant difference between reverberation subscale mean scores of three groups. Conclusion: It seems digital hearing aids may be more beneficial to reduce disability caused by hearing loss than analog and programmable hearing aids are.

ANALOGICAL REASONING USING TRANSFORMATIONS OF RULES

OpenAIRE

Haraguchi, Makoto; 原口, 誠

1986-01-01

A formalism of analogical reasoning is presented. The analogical reasoning can be considered as a deduction with a function of transforming logical rules. From this viewpoint, the reasoning is defined in terms of deduction, and is therefore realized in a logic programming system. The reasoning system is described as an extension of Prolog interpreter.

Automating analog design: Taming the shrew

Science.gov (United States)

Barlow, A.

1990-01-01

The pace of progress in the design of integrated circuits continues to amaze observers inside and outside of the industry. Three decades ago, a 50 transistor chip was a technological wonder. Fifteen year later, a 5000 transistor device would 'wow' the crowds. Today, 50,000 transistor chips will earn a 'not too bad' assessment, but it takes 500,000 to really leave an impression. In 1975 a typical ASIC device had 1000 transistors, took one year to first samples (and two years to production) and sold for about 5 cents per transistor. Today's 50,000 transistor gate array takes about 4 months from spec to silicon, works the first time, and sells for about 0.02 cents per transistor. Fifteen years ago, the single most laborious and error prone step in IC design was the physical layout. Today, most IC's never see the hand of a layout designer: and automatic place and route tool converts the engineer's computer captured schematic to a complete physical design using a gate array or a library of standard cells also created by software rather than by designers. CAD has also been a generous benefactor to the digital design process. The architect of today's digital systems creates the design using an RTL or other high level simulator. Then the designer pushes a button to invoke the logic synthesizer-optimizer tool. A fault analyzer checks the result for testability and suggests where scan based cells will improve test coverage. One obstinate holdout amidst this parade of progress is the automation of analog design and its reduction to semi-custom techniques. This paper investigates the application of CAD techniques to analog design.

Towards new analog read-out electronics for the HADES drift chamber system

Energy Technology Data Exchange (ETDEWEB)

Wiebusch, Michael [Goethe-Universitaet, Frankfurt (Germany); Collaboration: HADES-Collaboration

2016-07-01

Track reconstruction in HADES is realized with 24 planar, low-mass drift chambers (MDC). About 27000 drift cells provide precise spatial information of track hit points together with energy loss information, serving for particle ID. In order to handle high rates and track densities required at the future SIS100 accelerator at FAIR, an upgrade of the MDC system is necessary, i.e. by receiving additional redundant layers of drift cells in front of the magnet. This involves new front-end electronics, as the original analog read-out ASIC (ASD8) is no longer in stock and cannot be produced due to its legacy silicon process. Employing new FEE would allow to further increase the sensitivity, e.g. providing additional valuable information for the analysis. This contribution presents a market analysis of alternative state-of-the-art technologies for the analog read-out of drift chambers. Test procedures to evaluate the suitability for the HADES MDCs are discussed and preliminary results are shown. Emphasis is put on the benefits and possible implementations of using two separate analog channels for reading out a sense wire, i.e. a fast amplifier with a discriminator for recording the arrival time of the signal pulse and a slow integrating amplifier with a time-over-threshold discriminator to measure the total charge of the pulse.

COGMIR: A computer model for knowledge integration

Energy Technology Data Exchange (ETDEWEB)

Chen, Z.X.

1988-01-01

This dissertation explores some aspects of knowledge integration, namely, accumulation of scientific knowledge and performing analogical reasoning on the acquired knowledge. Knowledge to be integrated is conveyed by paragraph-like pieces referred to as documents. By incorporating some results from cognitive science, the Deutsch-Kraft model of information retrieval is extended to a model for knowledge engineering, which integrates acquired knowledge and performs intelligent retrieval. The resulting computer model is termed COGMIR, which stands for a COGnitive Model for Intelligent Retrieval. A scheme, named query invoked memory reorganization, is used in COGMIR for knowledge integration. Unlike some other schemes which realize knowledge integration through subjective understanding by representing new knowledge in terms of existing knowledge, the proposed scheme suggests at storage time only recording the possible connection of knowledge acquired from different documents. The actual binding of the knowledge acquired from different documents is deferred to query time. There is only one way to store knowledge and numerous ways to utilize the knowledge. Each document can be represented as a whole as well as its meaning. In addition, since facts are constructed from the documents, document retrieval and fact retrieval are treated in a unified way. When the requested knowledge is not available, query invoked memory reorganization can generate suggestion based on available knowledge through analogical reasoning. This is done by revising the algorithms developed for document retrieval and fact retrieval, and by incorporating Gentner's structure mapping theory. Analogical reasoning is treated as a natural extension of intelligent retrieval, so that two previously separate research areas are combined. A case study is provided. All the components are implemented as list structures similar to relational data-bases.

Josephson junction analog and quasiparticle-pair current

DEFF Research Database (Denmark)

Bak, Christen Kjeldahl; Pedersen, Niels Falsig

1973-01-01

A close analogy exists between a Josephson junction and a phase-locked loop. A new type of electrical analog based on this principle is presented. It is shown that the inclusion in this analog of a low-pass filter gives rise to a current of the same form as the Josephson quasiparticle-pair current....... A simple picture of the quasiparticle-pair current, which gives the right dependences, is obtained by assuming a junction cutoff frequency to be at the energy gap. ©1973 American Institute of Physics...

Fast parallel-series analog-to-digital converter

International Nuclear Information System (INIS)

Pogosov, A.Yu.

1987-01-01

Fast analog-to-digital converters are used in systems for detection of rapid processes, nuclear spectroscopy. A 12-digit analog-to-digital converter with conversion time of 160 ns and conversion frequency of 8.3 MHz is described; a segmented digital-to-analog converter with differential non-linearity of < 0.01% and a differential amplifier-limiter with setting time of 80 ns at the error of 0.2% are utilized in the converter; a control device is based on the chain of flip-flop circuit

Cyclopentanoid analogs of phosphatidylcholine: susceptibility to phospholipase A2.

Science.gov (United States)

Lister, M D; Hancock, A J

1988-10-01

Six isomers of dipalmitoylcyclopentanetriol phosphocholine (cyclopentano-lecithin) were tested as potential substrates for phospholipase A2. Since each of these analogs possesses a configuration that mimics a narrow range of conformations of a glycerophospholipid molecule, the analogs were used to assess the enzyme's conformational requirements. Studies showed that all of the analogs containing the phosphocholine at the C-1 (or C-3) position could be hydrolyzed, while only one of the three analogs that contains the polar head group at the C-2 position was susceptible. Kinetic studies, however, revealed that only the all-trans-(1,3/2-1P)-cyclopentano-lecithin gave initial rates of hydrolysis that were measurable by pH-stat. Acyl group specificity of the enzyme towards the all-trans isomer was determined with an analog was acyl groups were distinguishable. The synthesis of this mixed-acid-cyclopentano-PC is described herein. When this analog was enzymatically assayed, results unequivocally showed the enzyme to be specific for C-2 acyl hydrolysis. This specificity, and data showing that the all-trans analog is stereospecifically hydrolyzed, indicate that it is acted on in an analogous manner to dipalmitoylphosphatidylcholine. These studies indicate that although the configuration of the analog is not necessarily a prerequisite for hydrolysis, there does appear to be an optimal spatial orientation for enzymatic activity. The analogy between the susceptibilities of all-trans-(1,3/2-1P)-cyclopentano-lecithin and glycero-lecithin suggests that the conformation of the glycero-lecithin during phospholipase A2-mediated hydrolysis may be best simulated by the all-trans orientation of C-O bonds in the artificial substrate.

NaturAnalogs for the Unsaturated Zone

Energy Technology Data Exchange (ETDEWEB)

A. Simmons; A. Unger; M. Murrell

2000-03-08

The purpose of this Analysis/Model Report (AMR) is to document natural and anthropogenic (human-induced) analog sites and processes that are applicable to flow and transport processes expected to occur at the potential Yucca Mountain repository in order to build increased confidence in modeling processes of Unsaturated Zone (UZ) flow and transport. This AMR was prepared in accordance with ''AMR Development Plan for U0135, Natural Analogs for the UZ'' (CRWMS 1999a). Knowledge from analog sites and processes is used as corroborating information to test and build confidence in flow and transport models of Yucca Mountain, Nevada. This AMR supports the Unsaturated Zone (UZ) Flow and Transport Process Model Report (PMR) and the Yucca Mountain Site Description. The objectives of this AMR are to test and build confidence in the representation of UZ processes in numerical models utilized in the UZ Flow and Transport Model. This is accomplished by: (1) applying data from Boxy Canyon, Idaho in simulations of UZ flow using the same methodologies incorporated in the Yucca Mountain UZ Flow and Transport Model to assess the fracture-matrix interaction conceptual model; (2) Providing a preliminary basis for analysis of radionuclide transport at Pena Blanca, Mexico as an analog of radionuclide transport at Yucca Mountain; and (3) Synthesizing existing information from natural analog studies to provide corroborating evidence for representation of ambient and thermally coupled UZ flow and transport processes in the UZ Model.

Analogy, higher order thinking, and education.

Science.gov (United States)

Richland, Lindsey Engle; Simms, Nina

2015-01-01

Analogical reasoning, the ability to understand phenomena as systems of structured relationships that can be aligned, compared, and mapped together, plays a fundamental role in the technology rich, increasingly globalized educational climate of the 21st century. Flexible, conceptual thinking is prioritized in this view of education, and schools are emphasizing 'higher order thinking', rather than memorization of a cannon of key topics. The lack of a cognitively grounded definition for higher order thinking, however, has led to a field of research and practice with little coherence across domains or connection to the large body of cognitive science research on thinking. We review literature on analogy and disciplinary higher order thinking to propose that relational reasoning can be productively considered the cognitive underpinning of higher order thinking. We highlight the utility of this framework for developing insights into practice through a review of mathematics, science, and history educational contexts. In these disciplines, analogy is essential to developing expert-like disciplinary knowledge in which concepts are understood to be systems of relationships that can be connected and flexibly manipulated. At the same time, analogies in education require explicit support to ensure that learners notice the relevance of relational thinking, have adequate processing resources available to mentally hold and manipulate relations, and are able to recognize both the similarities and differences when drawing analogies between systems of relationships. © 2015 John Wiley & Sons, Ltd.

Analog forecasting with dynamics-adapted kernels

Science.gov (United States)

Zhao, Zhizhen; Giannakis, Dimitrios

2016-09-01

Analog forecasting is a nonparametric technique introduced by Lorenz in 1969 which predicts the evolution of states of a dynamical system (or observables defined on the states) by following the evolution of the sample in a historical record of observations which most closely resembles the current initial data. Here, we introduce a suite of forecasting methods which improve traditional analog forecasting by combining ideas from kernel methods developed in harmonic analysis and machine learning and state-space reconstruction for dynamical systems. A key ingredient of our approach is to replace single-analog forecasting with weighted ensembles of analogs constructed using local similarity kernels. The kernels used here employ a number of dynamics-dependent features designed to improve forecast skill, including Takens’ delay-coordinate maps (to recover information in the initial data lost through partial observations) and a directional dependence on the dynamical vector field generating the data. Mathematically, our approach is closely related to kernel methods for out-of-sample extension of functions, and we discuss alternative strategies based on the Nyström method and the multiscale Laplacian pyramids technique. We illustrate these techniques in applications to forecasting in a low-order deterministic model for atmospheric dynamics with chaotic metastability, and interannual-scale forecasting in the North Pacific sector of a comprehensive climate model. We find that forecasts based on kernel-weighted ensembles have significantly higher skill than the conventional approach following a single analog.

Natural Analogs for the Unsaturated Zone

International Nuclear Information System (INIS)

Simmons, A.; Unger, A.; Murrell, M.

2000-01-01

The purpose of this Analysis/Model Report (AMR) is to document natural and anthropogenic (human-induced) analog sites and processes that are applicable to flow and transport processes expected to occur at the potential Yucca Mountain repository in order to build increased confidence in modeling processes of Unsaturated Zone (UZ) flow and transport. This AMR was prepared in accordance with ''AMR Development Plan for U0135, Natural Analogs for the UZ'' (CRWMS 1999a). Knowledge from analog sites and processes is used as corroborating information to test and build confidence in flow and transport models of Yucca Mountain, Nevada. This AMR supports the Unsaturated Zone (UZ) Flow and Transport Process Model Report (PMR) and the Yucca Mountain Site Description. The objectives of this AMR are to test and build confidence in the representation of UZ processes in numerical models utilized in the UZ Flow and Transport Model. This is accomplished by: (1) applying data from Boxy Canyon, Idaho in simulations of UZ flow using the same methodologies incorporated in the Yucca Mountain UZ Flow and Transport Model to assess the fracture-matrix interaction conceptual model; (2) Providing a preliminary basis for analysis of radionuclide transport at Pena Blanca, Mexico as an analog of radionuclide transport at Yucca Mountain; and (3) Synthesizing existing information from natural analog studies to provide corroborating evidence for representation of ambient and thermally coupled UZ flow and transport processes in the UZ Model

Circuit with a successive approximation analog to digital converter

NARCIS (Netherlands)

Louwsma, S.M.; Vertregt, Maarten

2011-01-01

During successive approximation analog to digital conversion a series of successive digital reference values is selected that converges towards a digital representation of an analog input signal. An analog reference signal is generated dependent on the successive digital reference values and

Circuit with a successive approximation analog to digital converter

NARCIS (Netherlands)

Louwsma, S.M.; Vertregt, Maarten

2010-01-01

During successive approximation analog to digital conversion a series of successive digital reference values is selected that converges towards a digital representation of an analog input signal. An analog reference signal is generated dependent on the successive digital reference values and

16-channel analog store and multiplexer unit

Energy Technology Data Exchange (ETDEWEB)

Brossard, M; Kulka, Z [Clermont-Ferrand-2 Univ., 63 - Aubiere (France). Lab. de Physique Corpusculaire

1979-03-15

A 16-channel analog store and multiplexer unit is described. The unit enables storing and selection of analog information which is then digitally encoded by single ADC. This solution becomes economically attractive particularly in multidetector pulse height analysis systems.

High-yield production of herbicidal thaxtomins and analogs in a nonpathogenic Streptomyces strain.

Science.gov (United States)

Jiang, Guangde; Zhang, Yucheng; Powell, Magan M; Zhang, Peilan; Zuo, Ran; Zhang, Yi; Kallifidas, Dimitrios; Tieu, Albert M; Luesch, Hendrik; Loria, Rosemary; Ding, Yousong

2018-03-30

Thaxtomins are virulence factors of most plant pathogenic Streptomyces strains. Due to their potent herbicidal activity, attractive environmental compatibility and inherent biodegradability, thaxtomins are key active ingredients of bioherbicides approved by the United States Environmental Protection Agency. However, the low yield of thaxtomins in native Streptomyces producers limits their wide agricultural applications. Here, we describe the high-yield production of thaxtomins in a heterologous host. The thaxtomin gene cluster from S. scabiei 87.22 was cloned and expressed in S. albus J1074 after chromosomal integration. The production of thaxtomins and nitro-tryptophan analogs were observed using LC-MS analysis. When culturing the engineered S. albus J1074 in the minimal medium TMDc, the yield of the most abundant and herbicidal analog, thaxtomin A, was 10 times higher than S. scabiei 87.22, and optimization of the medium resulted in the highest yield of thaxtomin analogs at about 222 mg/L. Further engineering of the thaxtomin biosynthetic gene cluster through gene deletion led to the production of multiple biosynthetic intermediates important to the chemical synthesis of new analogs. Additionally, the versatility of the thaxtomin biosynthetic system in S. albus J1074 was capitalized to produce one unnatural fluorinated analog 5-F-thaxtomin A, whose structure was elucidated by a combination of MS and 1D and 2D NMR analyses. Natural and unnatural thaxtomins demonstrated potent herbicidal activity in radish seedling assays. These results indicated that S. albus J1074 has the potential to produce thaxtomins and thereof with high yield, fostering their agricultural applications. IMPORTANCE Thaxtomins are agriculturally valuable herbicidal natural products but the productivity of native producers is limiting. Heterologous expression of thaxtomin gene cluster in S. albus J1074 resulted in the highest yield of thaxtomins ever reported, representing a significant leap

Aida-CMK multi-algorithm optimization kernel applied to analog IC sizing

CERN Document Server

Lourenço, Ricardo; Horta, Nuno

2015-01-01

This work addresses the research and development of an innovative optimization kernel applied to analog integrated circuit (IC) design. Particularly, this works describes the modifications inside the AIDA Framework, an electronic design automation framework fully developed by at the Integrated Circuits Group-LX of the Instituto de Telecomunicações, Lisbon. It focusses on AIDA-CMK, by enhancing AIDA-C, which is the circuit optimizer component of AIDA, with a new multi-objective multi-constraint optimization module that constructs a base for multiple algorithm implementations. The proposed solution implements three approaches to multi-objective multi-constraint optimization, namely, an evolutionary approach with NSGAII, a swarm intelligence approach with MOPSO and stochastic hill climbing approach with MOSA. Moreover, the implemented structure allows the easy hybridization between kernels transforming the previous simple NSGAII optimization module into a more evolved and versatile module supporting multiple s...

10 K gate I(2)L and 1 K component analog compatible bipolar VLSI technology - HIT-2

Science.gov (United States)

Washio, K.; Watanabe, T.; Okabe, T.; Horie, N.

1985-02-01

An advanced analog/digital bipolar VLSI technology that combines on the same chip 2-ns 10 K I(2)L gates with 1 K analog devices is proposed. The new technology, called high-density integration technology-2, is based on a new structure concept that consists of three major techniques: shallow grooved-isolation, I(2)L active layer etching, and I(2)L current gain increase. I(2)L circuits with 80-MHz maximum toggle frequency have developed compatibly with n-p-n transistors having a BV(CE0) of more than 10 V and an f(T) of 5 GHz, and lateral p-n-p transistors having an f(T) of 150 MHz.

High-speed photonically assisted analog-to-digital conversion using a continuous wave multiwavelength source and phase modulation.

Science.gov (United States)

Bortnik, Bartosz J; Fetterman, Harold R

2008-10-01

A more simple photonically assisted analog-to-digital conversion system utilizing a cw multiwavelength source and phase modulation instead of a mode-locked laser is presented. The output of the cw multiwavelength source is launched into a dispersive device (such as a single-mode fiber). This fiber creates a pulse train, where the central wavelength of each pulse corresponds to a spectral line of the optical source. The pulses can then be either dispersed again to perform discrete wavelength time stretching or demultiplexed for continuous time analog-to-digital conversion. We experimentally demonstrate the operation of both time stretched and interleaved systems at 38 GHz. The potential of integrating this type of system on a monolithic chip is discussed.

An analog integrated front-end amplifier for neural applications

OpenAIRE

Zhou, Zhijun; Warr, Paul

2017-01-01

The front-end amplifier forms the critical element for signal detection and pre-processing within neural monitoring systems. It determines not only the fidelity of the biosignal, but also impacts power consumption and detector size. In this paper, a combined feedback loop-controlled approach is proposed to neutralize for the input leakage currents generated by low noise amplifiers when in integrated circuit form, alongside signal leakage into the input bias network. Significantly, this loop t...

Analogical Reasoning in the Engineering Design Process and Technology Education Applications

OpenAIRE

2008-01-01

This synthesis paper discusses the research exploring analogical reasoning, the role of analogies in the engineering design process, and educational applications for analogical reasoning. Researchers have discovered that analogical reasoning is often a fundamental cognitive tool in design problem solving. Regarding the possible role of analogical reasoning in the context of technology education; analogies may be a useful tool to develop student’s design skills, teach abstract or complex conce...

Eye Movements Reveal Optimal Strategies for Analogical Reasoning.

Science.gov (United States)

Vendetti, Michael S; Starr, Ariel; Johnson, Elizabeth L; Modavi, Kiana; Bunge, Silvia A

2017-01-01

Analogical reasoning refers to the process of drawing inferences on the basis of the relational similarity between two domains. Although this complex cognitive ability has been the focus of inquiry for many years, most models rely on measures that cannot capture individuals' thought processes moment by moment. In the present study, we used participants' eye movements to investigate reasoning strategies in real time while solving visual propositional analogy problems (A:B::C:D). We included both a semantic and a perceptual lure on every trial to determine how these types of distracting information influence reasoning strategies. Participants spent more time fixating the analogy terms and the target relative to the other response choices, and made more saccades between the A and B items than between any other items. Participants' eyes were initially drawn to perceptual lures when looking at response choices, but they nonetheless performed the task accurately. We used participants' gaze sequences to classify each trial as representing one of three classic analogy problem solving strategies and related strategy usage to analogical reasoning performance. A project-first strategy, in which participants first extrapolate the relation between the AB pair and then generalize that relation for the C item, was both the most commonly used strategy as well as the optimal strategy for solving visual analogy problems. These findings provide new insight into the role of strategic processing in analogical problem solving.

Eye Movements Reveal Optimal Strategies for Analogical Reasoning

Directory of Open Access Journals (Sweden)

Michael S. Vendetti

2017-06-01

Full Text Available Analogical reasoning refers to the process of drawing inferences on the basis of the relational similarity between two domains. Although this complex cognitive ability has been the focus of inquiry for many years, most models rely on measures that cannot capture individuals' thought processes moment by moment. In the present study, we used participants' eye movements to investigate reasoning strategies in real time while solving visual propositional analogy problems (A:B::C:D. We included both a semantic and a perceptual lure on every trial to determine how these types of distracting information influence reasoning strategies. Participants spent more time fixating the analogy terms and the target relative to the other response choices, and made more saccades between the A and B items than between any other items. Participants' eyes were initially drawn to perceptual lures when looking at response choices, but they nonetheless performed the task accurately. We used participants' gaze sequences to classify each trial as representing one of three classic analogy problem solving strategies and related strategy usage to analogical reasoning performance. A project-first strategy, in which participants first extrapolate the relation between the AB pair and then generalize that relation for the C item, was both the most commonly used strategy as well as the optimal strategy for solving visual analogy problems. These findings provide new insight into the role of strategic processing in analogical problem solving.

An Analog Computer for Electronic Engineering Education

Science.gov (United States)

Fitch, A. L.; Iu, H. H. C.; Lu, D. D. C.

2011-01-01

This paper describes a compact analog computer and proposes its use in electronic engineering teaching laboratories to develop student understanding of applications in analog electronics, electronic components, engineering mathematics, control engineering, safe laboratory and workshop practices, circuit construction, testing, and maintenance. The…

The interplay of conflict and analogy in multidisciplinary teams.

Science.gov (United States)

Paletz, Susannah B F; Schunn, Christian D; Kim, Kevin H

2013-01-01

Creative teamwork in multidisciplinary teams is a topic of interest to cognitive psychologists on the one hand, and to both social and organizational psychologists on the other. However, the interconnections between cognitive and social layers have been rarely explored. Drawing on mental models and dissonance theories, the current study takes a central variable studied by cognitive psychologists-analogy-and examines its relationship to a central variable examined by social psychologists-conflict. In an observational, field study, over 11h of audio-video data from conversations of the Mars Exploration Rover scientists were coded for different types of analogy and micro-conflicts that reveal the character of underlying psychological mechanisms. Two different types of time-lagged logistic models applied to these data revealed asymmetric patterns of associations between analogy and conflict. Within-domain analogies, but not within-discipline or outside-discipline analogies, preceded science and work process conflicts, suggesting that in multidisciplinary teams, representational gaps in very close domains will be more likely to spark conflict. But analogies also occurred in reaction to conflict: Process and negative conflicts, but not task conflicts, preceded within-discipline analogies, but not to within-domain or outside-discipline analogies. This study demonstrates ways in which cognition can be bidirectionally tied to social processes and discourse. Copyright © 2012 Elsevier B.V. All rights reserved.

Compressional effects in nonneutral plasmas, a shallow water analogy and m=1 instability

International Nuclear Information System (INIS)

Finn, J.M.; Del-Castillo-Negrete, D.; Barnes, D.C.

1999-01-01

Diocotron instabilities form an important class of ExB shear flow instabilities which occur in nonneutral plasmas. The case of a single-species plasma confined in a cylindrical Penning trap, with an axisymmetric, hollow (nonmonotonic) density profile is studied. According to the standard linear theory, the m=1, k z =0 diocotron mode is always stable. On the other hand, experiments by Driscoll [Phys. Rev. Lett. 64, 645 (1990)] show a robust exponential growth of m=1 diocotron perturbations in hollow density profiles. The apparent contradiction between these experimental results and linear theory has been an outstanding problem in the theory of nonneutral plasmas. A new instability mechanism due to the radial variation of the equilibrium plasma length is proposed in this paper. This mechanism involves the compression of the plasma parallel to the magnetic field and implies the conservation of the line integrated density. The predicted growth rate, frequency, and mode structure are in reasonable agreement with the experiment. The effect of a linear perturbation of the plasma length is also shown to give instability with a comparable growth rate. The conservation of the line integrated density in the plasma is analogous to the conservation of the potential vorticity in the shallow water equations used in geophysical fluid dynamics. In particular, there is an analog of Rossby waves in nonneutral plasmas. copyright 1999 American Institute of Physics

Fluorinated analogs of malachite green: synthesis and toxicity.

Science.gov (United States)

Kraus, George A; Jeon, Insik; Nilsen-Hamilton, Marit; Awad, Ahmed M; Banerjee, Jayeeta; Parvin, Bahram

2008-04-27

A series of fluorinated analogs of malachite green (MG) have been synthesized and their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell line examined. The toxicity profiles were found to be different for these two species. Two analogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem to be the most promising analogs because they showed the lowest toxicity to the human cells.

Analogies between classical statistical mechanics and quantum mechanics

International Nuclear Information System (INIS)

Uehara, M.

1986-01-01

Some analogies between nonequilibrium classical statistical mechanics and quantum mechanics, at the level of the Liouville equation and at the kinetic level, are commented on. A theorem, related to the Vlasov equation applied to a plasma, is proved. The theorem presents an analogy with Ehrenfest's theorem of quantum mechanics. An analogy between the plasma kinetic theory and Bohm's quantum theory with 'hidden variables' is also shown. (Author) [pt

Tracking cognitive phases in analogical reasoning with event-related potentials.

Science.gov (United States)

Maguire, Mandy J; McClelland, M Michelle; Donovan, Colin M; Tillman, Gail D; Krawczyk, Daniel C

2012-03-01

Analogical reasoning consists of multiple phases. Four-term analogies (A:B::C:D) have an encoding period in which the A:B pair is evaluated prior to a mapping phase. The electrophysiological timing associated with analogical reasoning has remained unclear. We used event-related potentials to identify neural timing related to analogical reasoning relative to perceptual and semantic control conditions. Spatiotemporal principal-components analyses revealed differences primarily in left frontal electrodes during encoding and mapping phases of analogies relative to the other conditions. The timing of the activity differed depending upon the phase of the problem. During the encoding of A:B terms, analogies elicited a positive deflection compared to the control conditions between 400 and 1,200 ms, but for the mapping phase analogical processing elicited a negative deflection that occurred earlier and for a shorter time period, between 350 and 625 ms. These results provide neural and behavioral evidence that 4-term analogy problems involve a highly active evaluation phase of the A:B pair. 2012 APA, all rights reserved

HAPS, a Handy Analog Programming System

DEFF Research Database (Denmark)

Højberg, Kristian Søe

1975-01-01

HAPS (Hybrid Analog Programming System) is an analog compiler that can be run on a minicomputer in an interactive mode. Essentially HAPS is written in FORTRAN. The equations to be programmed for an ana log computer are read in by using a FORTRAN-like notation. The input must contain maximum...... and emphasizes the limitations HAPS puts on equation structure, types of computing circuit, scaling, and static testing....

The use of analogy in pro-life argumentation

Directory of Open Access Journals (Sweden)

Simona Mazilu

2012-11-01

Full Text Available The paper is concerned with how analogy is strategically used in pro-life argumentation on abortion. Pragma-dialectics (van Eemeren and Grootendorst 1992 offers a set of critical questions by means of which I will evaluate the use of the argumentation based on a relation of analogy in terms of dialectical soundness. Examining various pro-life texts, I have noticed that the analogies employed remain unexplained. Therefore, despite the apparent similarities between abortion and the German holocaust or slavery, for instance, there are essential differences which are not mentioned. I claim that these analogies mainly have a rhetorical function, to operate what has been called by Micheli (2007: 960 “a transfer of emotional consensus”.

Patterns of Analogical Reasoning among Beginning Readers

Science.gov (United States)

Farrington-Flint, Lee; Wood, Clare; Canobi, Katherine H.; Faulkner, Dorothy

2004-01-01

Despite compelling evidence that analogy skills are available to beginning readers, few studies have actually explored the possibility of identifying individual differences in young children's analogy skills in early reading. The present study examined individual differences in children's use of orthographic and phonological relations between…

Single-event transients (SET) in analog circuits

International Nuclear Information System (INIS)

Chen Panxun; Zhou Kaiming

2006-01-01

A new phenomenon of single- event upset is introduced. The transient signal is produced in the output of analog circuits after a heavy ion strikes. The transient upset can influence the circuit connected with the output of analog circuits. For example, the output of operational amplifier can be connected with the input of a digital counter, and the pulse of sufficiently high transient output induced by an ion can increase counts of the counter. On the other hand, the transient voltage signal at the output of analog circuits can change the stage of other circuits. (authors)

A novel analog/digital reconfigurable automatic gain control with a novel DC offset cancellation circuit

Energy Technology Data Exchange (ETDEWEB)

He Xiaofeng; Ye Tianchun [Institute of Microelectronics, Chinese Academy of Science, Beijing 100029 (China); Mo Taishan; Ma Chengyan, E-mail: hexiaofeng@casic.ac.cn [Hangzhou Zhongke Microelectronics Co, Ltd, Hangzhou 310053 (China)

2011-02-15

An analog/digital reconfigurable automatic gain control (AGC) circuit with a novel DC offset cancellation circuit for a direct-conversion receiver is presented. The AGC is analog/digital reconfigurable in order to be compatible with different baseband chips. What's more, a novel DC offset cancellation (DCOC) circuit with an HPCF (high pass cutoff frequency) less than 10 kHz is proposed. The AGC is fabricated by a 0.18 {mu}m CMOS process. Under analog control mode, the AGC achieves a 70 dB dynamic range with a 3 dB-bandwidth larger than 60 MHz. Under digital control mode, through a 5-bit digital control word, the AGC shows a 64 dB gain control range by 2 dB each step with a gain error of less than 0.3 dB. The DC offset cancellation circuits can suppress the output DC offset voltage to be less than 1.5 mV, while the offset voltage of 40 mV is introduced into the input. The overall power consumption is less than 3.5 mA, and the die area is 800 x 300 {mu}m{sup 2}. (semiconductor integrated circuits)

Reynolds analogy for the Rayleigh problem at various flow modes.

Science.gov (United States)

Abramov, A A; Butkovskii, A V

2016-07-01

The Reynolds analogy and the extended Reynolds analogy for the Rayleigh problem are considered. For a viscous incompressible fluid we derive the Reynolds analogy as a function of the Prandtl number and the Eckert number. We show that for any positive Eckert number, the Reynolds analogy as a function of the Prandtl number has a maximum. For a monatomic gas in the transitional flow regime, using the direct simulation Monte Carlo method, we investigate the extended Reynolds analogy, i.e., the relation between the shear stress and the energy flux transferred to the boundary surface, at different velocities and temperatures. We find that the extended Reynolds analogy for a rarefied monatomic gas flow with the temperature of the undisturbed gas equal to the surface temperature depends weakly on time and is close to 0.5. We show that at any fixed dimensionless time the extended Reynolds analogy depends on the plate velocity and temperature and undisturbed gas temperature mainly via the Eckert number. For Eckert numbers of the order of unity or less we generalize an extended Reynolds analogy. The generalized Reynolds analogy depends mainly only on dimensionless time for all considered Eckert numbers of the order of unity or less.

Two analogy strategies: the cases of mind metaphors and introspection

Science.gov (United States)

Fischer, Eugen

2018-04-01

Analogical reasoning is often employed in problem-solving and metaphor interpretation. This paper submits that, as a default, analogical reasoning addressing these different tasks employs different mapping strategies. In problem-solving, it employs analogy-maximising strategies (like structure mapping, Gentner, D., & Markman, A. B. (1997). Structure mapping in analogy and similarity. American Psychologist, 52, 45-56); in metaphor interpretation, analogy-minimising strategies (like ATT-Meta, Barnden, J. A. (2015). Open-ended elaborations in creative metaphor. In T. R. Besold, M. Schorlemmer, & A. Smaill (Eds.), Computational creativity research: Towards creative machines (pp. 217-242). Berlin: Springer). The two strategies interact in analogical reasoning with conceptual metaphors. This interaction leads to predictable fallacies. The paper supports these hypotheses through case-studies on "mind" metaphors from ordinary discourse, and abstract problem-solving in the philosophy of mind, respectively. It shows that (1) default metaphorical interpretations for vision- and space-cognition metaphors can be derived with a variant of the analogy-minimising ATT-Meta approach, (2) philosophically influential introspective conceptions of the mind can be derived with conceptual metaphors only through an analogy-maximising strategy, and (3) the interaction of these strategies leads to hitherto unrecognised fallacies in analogical reasoning with metaphors. This yields a debunking explanation of introspective conceptions.

25th workshop on Advances in Analog Circuit Design

CERN Document Server

Harpe, Pieter; Makinwa, Kofi

2017-01-01

This book is based on the 18 tutorials presented during the 25th workshop on Advances in Analog Circuit Design. Expert designers present readers with information about a variety of topics at the frontier of analog circuit design, including low-power and energy-efficient analog electronics, with specific contributions focusing on the design of continuous-time sigma-delta modulators, automotive electronics, and power management. This book serves as a valuable reference to the state-of-the-art, for anyone involved in analog circuit research and development.

Integrating Computational Thinking into Technology and Engineering Education

Science.gov (United States)

Hacker, Michael

2018-01-01

Computational Thinking (CT) is being promoted as "a fundamental skill used by everyone in the world by the middle of the 21st Century" (Wing, 2006). CT has been effectively integrated into history, ELA, mathematics, art, and science courses (Settle, et al., 2012). However, there has been no analogous effort to integrate CT into…

The mixed analog/digital shaper of the LHCb preshower

CERN Document Server

Lecoq, J; Cornat, R; Perret, P; Trouilleau, C

2001-01-01

The LHCb preshower signals show so many fluctuations at low energy that a classical shaping is not usable at all. Thanks to the fact that the fraction of the collected energy during a whole LHC beam crossing time is 85%, we studied the special solution we presented at Snowmass 1999 workshop. This solution consists of 2 interleaved fast integrators, one being in integrate mode when the other is digitally reset. Two track-and-hold systems and an analog multiplexer are used to give at the output 85% of the signal plus 15% of the previous one. These 15% are digitally computed from the previous sample, and subtracted. A completely new design of this solution had to be made. This new design is described, including new methods to decrease the supply voltage and the noise, as well as to increase the quality of the reset and the linearity. An output stage, consisting of an AB class push-pull using only NPN transistors is also described. Laboratory and beam test results are given. (5 refs).

Is the Link from Working Memory to Analogy Causal? No Analogy Improvements following Working Memory Training Gains

OpenAIRE

Richey, J. Elizabeth; Phillips, Jeffrey S.; Schunn, Christian D.; Schneider, Walter

2014-01-01

Analogical reasoning has been hypothesized to critically depend upon working memory through correlational data [1], but less work has tested this relationship through experimental manipulation [2]. An opportunity for examining the connection between working memory and analogical reasoning has emerged from the growing, although somewhat controversial, body of literature suggests complex working memory training can sometimes lead to working memory improvements that transfer to novel working mem...

Selective termination, fetal reduction and analogical reasoning.

Science.gov (United States)

Pennings, G

2013-06-01

Analogical reasoning is a basic method in bioethics. Its main purpose is to transfer the rule from an existing or known situation to a new and problematic situation. This commentary applies the lifeboat analogy to the context of selective termination and fetal reduction. It turns out that the analogy is only partially helpful as the main principle in the case of selective termination is the procreative beneficence principle. However, the wide person-affecting form of this principle doubly justifies selective termination: i.e. one prevents the harm caused by the birth of an affected child and one increases the life chances of the remaining fetuses. I conclude, however, that all analogies are basically flawed since they assume that fetuses as such have interests. I argue that fetuses only have interests to the extent that they are potential future persons. Copyright © 2013 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

The design analogy : a model for moral problem solving

NARCIS (Netherlands)

Dorst, C.H.; Royakkers, L.M.M.

2006-01-01

In this paper we explore an analogy between design and ethics, first drawn by Whitbeck. We investigate her claim that such an analogy can help to understand moral problems and aid us in dealing with them by suggesting strategies for addressing moral problems. We explore the nature of analogies, and

Path integral for relativistic particle theory

International Nuclear Information System (INIS)

Fradkin, E.S.; Gitman, D.M.; Shvartsman, Sh.M.

1990-06-01

An action for a relativistic spinning particle interacting with external electromagnetic field is considered in reparametrization and local supergauge invariant form. It is shown that various path integral representations derived for the causal Green function correspond to the different forms of the relativistic particle action. The analogy of the path integral derived with the Lagrangian path integral of the field theory is discussed. It is shown that to obtain the causal propagator, the integration over the null mode of the Lagrangian multiplier corresponding to the reparametrization invariance, has to be performed in the (0,+infinity) limits. (author). 23 refs

Analog Electronic Filters Theory, Design and Synthesis

CERN Document Server

Dimopoulos, Hercules G

2012-01-01

Filters are essential subsystems in a huge variety of electronic systems. Filter applications are innumerable; they are used for noise reduction, demodulation, signal detection, multiplexing, sampling, sound and speech processing, transmission line equalization and image processing, to name just a few. In practice, no electronic system can exist without filters. They can be found in everything from power supplies to mobile phones and hard disk drives and from loudspeakers and MP3 players to home cinema systems and broadband Internet connections. This textbook introduces basic concepts and methods and the associated mathematical and computational tools employed in electronic filter theory, synthesis and design.  This book can be used as an integral part of undergraduate courses on analog electronic filters. Includes numerous, solved examples, applied examples and exercises for each chapter. Includes detailed coverage of active and passive filters in an independent but correlated manner. Emphasizes real filter...

Modern Communication: Exploring Physiological Transmission through Tech-Savvy Analogies

Science.gov (United States)

Hollabaugh, Christopher R.; Milanick, Mark A.

2014-01-01

Analogies are often helpful for students to grasp key physiological concepts; sometimes the technical jargon makes the concept seem more complex than it actually is. In this article the authors provide several analogies for information transfer processes that sometimes confuse students. For an analogy to be useful, of course, it needs to be…

AnalogRF and mixed-signal circuit systematic design

CERN Document Server

Tlelo-Cuautle, Esteban; Castro-Lopez, Rafael

2013-01-01

Despite the fact that in the digital domain, designers can take full benefits of IPs and design automation tools to synthesize and design very complex systems, the analog designers’ task is still considered as a ‘handcraft’, cumbersome and very time consuming process. Thus, tremendous efforts are being deployed  to develop new design methodologies in the analog/RF and mixed-signal domains. This book collects 16 state-of-the-art contributions devoted to the topic of systematic design of analog, RF and mixed signal circuits. Divided in the two parts Methodologies and Techniques recent theories, synthesis techniques and design methodologies, as well as new sizing approaches in the field of robust analog and mixed signal design automation are presented for researchers and R/D engineers.  

Proportional and functional analogical reasoning in normal and language-impaired children.

Science.gov (United States)

Nippold, M A; Erskine, B J; Freed, D B

1988-11-01

Teachers often use analogies in classroom settings to clarify new concepts for their students. However, analogies may inadvertently confuse the youngster who has difficulty identifying the one-to-one comparisons underlying them. Although analogical reasoning has been studied extensively in normal children, no information was available concerning this construct in children having a specific language impairment. Thus, it was unknown to what extent they might be deficient in analogical reasoning. Therefore, in the present study, 20 children ages 6-8 years (mean age = 7:6) having normal nonverbal intelligence but deficits in language comprehension were administered tasks of verbal and perceptual proportional analogical reasoning and a problem-solving task of functional analogical reasoning. Compared to a normal-language control group matched on the basis of chronological age and sex, the language-impaired group was deficient in all three tasks of analogical reasoning. However, when the factor of nonverbal intelligence was controlled statistically, the differences between the groups on each of the tasks were removed. Additional findings were that verbal proportional analogical reasoning was significantly correlated to perceptual proportional analogical reasoning and to functional analogical reasoning. Implications for assessment and intervention with young school-age language-impaired children are discussed.

Analogical reasoning and aging: the processing speed and inhibition hypothesis.

Science.gov (United States)

Bugaiska, Aurélia; Thibaut, Jean-Pierre

2015-01-01

This study was designed to investigate the effect of aging on analogical reasoning by manipulating the strength of semantic association (LowAssoc or HighAssoc) and the number of distracters' semantic analogies of the A:B::C:D type and to determine which factors might be responsible for the age-related differences on analogical reasoning by testing two different theoretical frameworks: the inhibition hypothesis and the speed mediation hypothesis. We compared young adults and two groups of aging people (old and old-old) with word analogies of the A:B::C:D format. Results indicate an age-related effect on analogical reasoning, this effect being greatest with LowAssoc analogies. It was not associated with the presence of semantic distractors. Moreover, the results show that the variance part of the analogy task due to age was mainly explained by processing speed (rather than by inhibition) in the case of old participants and by both processing speed and inhibition in the old-old group. These results are discussed in relation to current models of aging and their interaction with the processes involved in analogical reasoning.

Analogy as a means of theoretical adoption of pedagogical disciplines

Directory of Open Access Journals (Sweden)

Solovcova Irina A.

2006-01-01

Full Text Available The paper considers an application of analogy in the initial-teacher training as a tool of approaching pedagogical disciplines. The author proposes a classification of pedagogical analogies which provides choices of the most efficient model for a specific didactic situation. The article clarifies the model of the theoretical approach to pedagogical disciplines through active use of analogy, which contributes to a higher efficiency in a teacher and student interaction. The model consists of three stages: training (the stage of acquiring analogy model, the analytical stage (acquisition of pedagogical concepts, phenomena and systems through the application of analogy, and the stage of self-realization (the application of analogy method in students’ scientific-research activities considering external and internal didactic conditions which transform analogy from a teaching method into a tool for the acquisition of pedagogical disciplines. The author demonstrates that the application of analogy has a positive effect not only on the acquisition of pedagogical knowledge (especially methodic and the development of heuristic skills in students, but also on motivation for the study of pedagogical disciplines (cognitive aspect and professional pedagogical activity (formation of an individual-pedagogical attitude. .

Synthetic Biology: A Unifying View and Review Using Analog Circuits.

Science.gov (United States)

Teo, Jonathan J Y; Woo, Sung Sik; Sarpeshkar, Rahul

2015-08-01

We review the field of synthetic biology from an analog circuits and analog computation perspective, focusing on circuits that have been built in living cells. This perspective is well suited to pictorially, symbolically, and quantitatively representing the nonlinear, dynamic, and stochastic (noisy) ordinary and partial differential equations that rigorously describe the molecular circuits of synthetic biology. This perspective enables us to construct a canonical analog circuit schematic that helps unify and review the operation of many fundamental circuits that have been built in synthetic biology at the DNA, RNA, protein, and small-molecule levels over nearly two decades. We review 17 circuits in the literature as particular examples of feedforward and feedback analog circuits that arise from special topological cases of the canonical analog circuit schematic. Digital circuit operation of these circuits represents a special case of saturated analog circuit behavior and is automatically incorporated as well. Many issues that have prevented synthetic biology from scaling are naturally represented in analog circuit schematics. Furthermore, the deep similarity between the Boltzmann thermodynamic equations that describe noisy electronic current flow in subthreshold transistors and noisy molecular flux in biochemical reactions has helped map analog circuit motifs in electronics to analog circuit motifs in cells and vice versa via a `cytomorphic' approach. Thus, a body of knowledge in analog electronic circuit design, analysis, simulation, and implementation may also be useful in the robust and efficient design of molecular circuits in synthetic biology, helping it to scale to more complex circuits in the future.

Abstract analogical reasoning in high-functioning children with autism spectrum disorders.

Science.gov (United States)

Green, Adam E; Kenworthy, Lauren; Mosner, Maya G; Gallagher, Natalie M; Fearon, Edward W; Balhana, Carlos D; Yerys, Benjamin E

2014-12-01

Children with autism spectrum disorders (ASD) exhibit a deficit in spontaneously recognizing abstract similarities that are crucial for generalizing learning to new situations. This may contribute to deficits in the development of appropriate schemas for navigating novel situations, including social interactions. Analogical reasoning is the central cognitive mechanism that enables typically developing children to understand abstract similarities between different situations. Intriguingly, studies of high-functioning children with ASD point to a relative cognitive strength in basic, nonabstract forms of analogical reasoning. If this analogical reasoning ability extends to abstract analogical reasoning (i.e., between superficially dissimilar situations), it may provide a bridge between a cognitive capability and core ASD deficits in areas such as generalization and categorization. This study tested whether preserved analogical reasoning abilities in ASD can be extended to abstract analogical reasoning, using photographs of real-world items and situations. Abstractness of the analogies was determined via a quantitative measure of semantic distance derived from latent semantic analysis. Children with ASD performed as well as typically developing children at identifying abstract analogical similarities when explicitly instructed to apply analogical reasoning. Individual differences in abstract analogical reasoning ability predicted individual differences in a measure of social function in the ASD group. Preliminary analyses indicated that children with ASD, but not typically developing children, showed an effect of age on abstract analogical reasoning. These results provide new evidence that children with ASD are capable of identifying abstract similarities through analogical reasoning, pointing to abstract analogical reasoning as a potential lever for improving generalization skills and social function in ASD. © 2014 International Society for Autism Research, Wiley

Quantum Analog Computing

Science.gov (United States)

Zak, M.

1998-01-01

Quantum analog computing is based upon similarity between mathematical formalism of quantum mechanics and phenomena to be computed. It exploits a dynamical convergence of several competing phenomena to an attractor which can represent an externum of a function, an image, a solution to a system of ODE, or a stochastic process.

Fast event recorder utilizing a CCD analog shift register

International Nuclear Information System (INIS)

Ducar, R.J.; McIntyre, P.M.

1978-01-01

A system of electronics has been developed to allow the capture and recording of relatively fast, low-amplitude analog events. The heart of the system is a dual 455-cell analog shift register charge-coupled device, Fairchild CCD321ADC-3. The CCD is operated in a dual clock mode. The input is sampled at a selectable clock rate of .25-20 MHz. The stored analog data is then clocked out at a slower rate, typically about .25 MHz. The time base expansion of the analog data allows for analog-to-digital conversion and memory storage using conventional medium-speed devices. The digital data is sequentially loaded into a static RAM and may then be block transferred to a computer. The analog electronics are housed in a single-width NIM module, and the RAM memory in a single-width CAMAC module. Each pair of modules provides six parallel channels. Cost is about $200.00 per channel. Applications are described for ionization imaging (TPC, IRC) and long-drift calorimetry in liquid argon

Changes in analogical reasoning in adulthood.

Science.gov (United States)

Clark, E; Gardner, M K; Brown, G; Howell, R J

1990-01-01

This study sought to investigate adult intellectual development through an analysis of a particular type of cognitive ability, verbal analogical reasoning. The performance of 60 individuals between the ages of 20 and 79 was compared on 100 verbal analogies. The subjects consisted of six groups of ten individuals each (five males and five females), matched as a group for education and gender. Solution times and error rates served as the dependent measures. Results showed that there was a significant trend for the older subjects (60- and 70-year-olds) to be slower than the young subjects (20-, 30-, 40-, and 50-year-olds), but not necessarily more error prone. These data suggest that verbal analogical reasoning changes with age. Supplemental data demonstrated a change in other abilities as well (i.e., decline in perceptual-motor speed and spatial skill).

Electrical analog of a Josephson junction

International Nuclear Information System (INIS)

Goldman, A.M.

1979-01-01

It is noted that a mathematical description of the phase-coupling of two oscillators synchronized by a phase-lock-loop under the influence of thermal white noise is analogous to that of the phase coupling of two superconductors in a Josephson junction also under the influence of noise. This analogy may be useful in studying threshold instabilities of the Josephson junction in regimes not restricted to the case of large damping. This is of interest because the behavior of the mean voltage near the threshold current can be characterized by critical exponents which resemble those exhibited by an order parameter of a continuous phase transition. As it is possible to couple a collection of oscillators together in a chain, the oscillator analogy may also be useful in exploring the dynamics and statistical mechanics of coupled junctions

Understanding the generative capacity of analogies as a tool for explanation

Science.gov (United States)

Wong, E. David

1993-12-01

Psychological studies have typically portrayed analogical reasoning as a process of schema transfer from a familiar domain of understanding to a problem situation. These studies have usually examined analogical reasoning in contexts where (a) individuals possess or have been provided with appropriate, problem-specific schema, (b) the nature of the problem and/or solution is fairly well defined, and (c) ideal analogies are provided or suggested by an outside source. This study examines analogical reasoning in contexts where understanding is generated from loosely organized, incomplete prior knowledge rather than transferred from a well-structured domain of understanding. In addition, participants were asked to create, apply, and modify their own analogies - as opposed to applying a given analogy - as a heuristic for constructing, evaluating, and modifying their explanations for a particular scientific phenomena. The results provide empirical support for the generative properties of analogies; that is, analogies can stimulate new inferences and insight. Furthermore, under specific conditions, individuals can productively harness the generative capacity of their own analogies to advance their conceptual understanding of scientific phenomena.

NASA Software Cost Estimation Model: An Analogy Based Estimation Model

Science.gov (United States)

Hihn, Jairus; Juster, Leora; Menzies, Tim; Mathew, George; Johnson, James

2015-01-01

The cost estimation of software development activities is increasingly critical for large scale integrated projects such as those at DOD and NASA especially as the software systems become larger and more complex. As an example MSL (Mars Scientific Laboratory) developed at the Jet Propulsion Laboratory launched with over 2 million lines of code making it the largest robotic spacecraft ever flown (Based on the size of the software). Software development activities are also notorious for their cost growth, with NASA flight software averaging over 50% cost growth. All across the agency, estimators and analysts are increasingly being tasked to develop reliable cost estimates in support of program planning and execution. While there has been extensive work on improving parametric methods there is very little focus on the use of models based on analogy and clustering algorithms. In this paper we summarize our findings on effort/cost model estimation and model development based on ten years of software effort estimation research using data mining and machine learning methods to develop estimation models based on analogy and clustering. The NASA Software Cost Model performance is evaluated by comparing it to COCOMO II, linear regression, and K-­ nearest neighbor prediction model performance on the same data set.

Emergent Explorations: Analog and Digital Scripting

OpenAIRE

Worden, Alexander

2011-01-01

This book documents an exploration of emergent and linear modes of defining space, form, and structure. The thesis highlights a dialog between analog and digital modeling techniques, in concept and project development. It identifies that analog modeling techniques, coupled with judgment, can be used to develop complex forms. The thesis project employs critical judgment and the textile techniques of crochet as a vehicle generate form. Crochet lends itself to this investigation because it ...

Design of CMOS analog integrated fractional-order circuits applications in medicine and biology

CERN Document Server

Tsirimokou, Georgia; Elwakil, Ahmed

2017-01-01

This book describes the design and realization of analog fractional-order circuits, which are suitable for on-chip implementation, capable of low-voltage operation and electronic adjustment of their characteristics. The authors provide a brief introduction to fractional-order calculus, followed by design issues for fractional-order circuits of various orders and types. The benefits of this approach are demonstrated with current-mode and voltage-mode filter designs. Electronically tunable emulators of fractional-order capacitors and inductors are presented, where the behavior of the corresponding chips fabricated using the AMS 0.35um CMOS process has been experimentally verified. Applications of fractional-order circuits are demonstrated, including a pre-processing stage suitable for the implementation of the Pan-Tompkins algorithm for detecting the QRS complexes of an electrocardiogram (ECG), a fully tunable implementation of the Cole-Cole model used for the modeling of biological tissues, and a simple, non-i...

Young Children's Analogical Reasoning in Science Domains

Science.gov (United States)

Haglund, Jesper; Jeppsson, Fredrik; Andersson, Johanna

2012-01-01

This exploratory study in a classroom setting investigates first graders' (age 7-8 years, N = 25) ability to perform analogical reasoning and create their own analogies for two irreversible natural phenomena: mixing and heat transfer. We found that the children who contributed actively to a full-class discussion were consistently successful at…

Children's Use of Analogy during Collaborative Reasoning

Science.gov (United States)

Lin, Tzu-Jung; Anderson, Richard C.; Hummel, John E.; Jadallah, May; Miller, Brian W.; Nguyen-Jahiel, Kim; Morris, Joshua A.; Kuo, Li-Jen; Kim, Il-Hee; Wu, Xiaoying; Dong, Ting

2012-01-01

This microgenetic study examined social influences on children's development of analogical reasoning during peer-led small-group discussions of stories about controversial issues. A total of 277 analogies were identified among 7,215 child turns for speaking during 54 discussions from 18 discussion groups in 6 fourth-grade classrooms (N = 120; age…

Bioprinting of Micro-Organ Tissue Analog for Drug Metabolism Study

Science.gov (United States)

Sun, Wei

An evolving application of tissue engineering is to develop in vitro 3D cell/tissue models for drug screening and pharmacological study. In order to test in space, these in vitro models are mostly manufactured through micro-fabrication techniques and incorporate living cells with MEMS or microfluidic devices. These cell-integrated microfluidic devices, or referred as microorgans, are effective in furnishing reliable and inexpensive drug metabolism and toxicity studies [1-3]. This paper will present an on-going research collaborated between Drexel University and NASA JSC Radiation Physics Laboratory for applying a direct cell printing technique to freeform fabrication of 3D liver tissue analog in drug metabolism study. The paper will discuss modeling, design, and solid freeform fabrication of micro-fluidic flow patterns and bioprinting of 3D micro-liver chamber that biomimics liver physiological microenvironment for enhanced drug metabolization. Technical details to address bioprinting of 3D liver tissue analog, integration with a microfluidic device, and basic drug metabolism study for NASA's interests will presented. 1. Holtorf H. Leslie J. Chang R, Nam J, Culbertson C, Sun W, Gonda S, "Development of a Three-Dimensional Tissue-on-a-Chip Micro-Organ Device for Pharmacokinetic Analysis", the 47th Annual Meeting of the American Society for Cell Biology, Washington, DC, December 1-5, 2007. 2. Chang, R., Nam, J., Culbertson C., Holtorf, H., Jeevarajan, A., Gonda, S. and Sun, W., "Bio-printing and Modeling of Flow Patterns for Cell Encapsulated 3D Liver Chambers For Pharmacokinetic Study", TERMIS North America 2007 Conference and Exposition, Westin Harbour Castle, Toronto, Canada, June 13-16, 2007. 3.Starly, B., Chang, R., Sun, W., Culbertson, C., Holtorf, H. and Gonda, S., "Bioprinted Tissue-on-chip Application for Pharmacokinetic Studies", Proceedings of World Congress on Tissue Engineering and Regenerative Medicine, Pittsburgh, PA, USA, April 24-27, 2006.

Model, analysis, and evaluation of the effects of analog VLSI arithmetic on linear subspace-based image recognition.

Science.gov (United States)

Carvajal, Gonzalo; Figueroa, Miguel

2014-07-01

Typical image recognition systems operate in two stages: feature extraction to reduce the dimensionality of the input space, and classification based on the extracted features. Analog Very Large Scale Integration (VLSI) is an attractive technology to achieve compact and low-power implementations of these computationally intensive tasks for portable embedded devices. However, device mismatch limits the resolution of the circuits fabricated with this technology. Traditional layout techniques to reduce the mismatch aim to increase the resolution at the transistor level, without considering the intended application. Relating mismatch parameters to specific effects in the application level would allow designers to apply focalized mismatch compensation techniques according to predefined performance/cost tradeoffs. This paper models, analyzes, and evaluates the effects of mismatched analog arithmetic in both feature extraction and classification circuits. For the feature extraction, we propose analog adaptive linear combiners with on-chip learning for both Least Mean Square (LMS) and Generalized Hebbian Algorithm (GHA). Using mathematical abstractions of analog circuits, we identify mismatch parameters that are naturally compensated during the learning process, and propose cost-effective guidelines to reduce the effect of the rest. For the classification, we derive analog models for the circuits necessary to implement Nearest Neighbor (NN) approach and Radial Basis Function (RBF) networks, and use them to emulate analog classifiers with standard databases of face and hand-writing digits. Formal analysis and experiments show how we can exploit adaptive structures and properties of the input space to compensate the effects of device mismatch at the application level, thus reducing the design overhead of traditional layout techniques. Results are also directly extensible to multiple application domains using linear subspace methods. Copyright © 2014 Elsevier Ltd. All rights

Radio-frequency integrated-circuit engineering

CERN Document Server

Nguyen, Cam

2015-01-01

Radio-Frequency Integrated-Circuit Engineering addresses the theory, analysis and design of passive and active RFIC's using Si-based CMOS and Bi-CMOS technologies, and other non-silicon based technologies. The materials covered are self-contained and presented in such detail that allows readers with only undergraduate electrical engineering knowledge in EM, RF, and circuits to understand and design RFICs. Organized into sixteen chapters, blending analog and microwave engineering, Radio-Frequency Integrated-Circuit Engineering emphasizes the microwave engineering approach for RFICs. Provide

Fully integrated digital GAMMA camera-computer system

International Nuclear Information System (INIS)

Berger, H.J.; Eisner, R.L.; Gober, A.; Plankey, M.; Fajman, W.

1985-01-01

Although most of the new non-nuclear imaging techniques are fully digital, there has been a reluctance in nuclear medicine to abandon traditional analog planar imaging in favor of digital acquisition and display. The authors evaluated a prototype digital camera system (GE STARCAM) in which all of the analog acquisition components are replaced by microprocessor controls and digital circuitry. To compare the relative effects of acquisition matrix size on image quality and to ascertain whether digital techniques could be used in place of analog imaging, Tc-99m bone scans were obtained on this digital system and on a comparable analog camera in 10 patients. The dedicated computer is used for camera setup including definition of the energy window, spatial energy correction, and spatial distortion correction. The display monitor, which is used for patient positioning and image analysis, is 512/sup 2/ non-interlaced, allowing high resolution imaging. Data acquisition and processing can be performed simultaneously. Thus, the development of a fully integrated digital camera-computer system with optimized display should allow routine utilization of non-analog studies in nuclear medicine and the ultimate establishment of fully digital nuclear imaging laboratories

Analogical Reasoning in the Engineering Design Process and Technology Education Applications

Science.gov (United States)

Daugherty, Jenny; Mentzer, Nathan

2008-01-01

This synthesis paper discusses the research exploring analogical reasoning, the role of analogies in the engineering design process, and educational applications for analogical reasoning. Researchers have discovered that analogical reasoning is often a fundamental cognitive tool in design problem solving. Regarding the possible role of analogical…

Complete integrability of the difference evolution equations

International Nuclear Information System (INIS)

Gerdjikov, V.S.; Ivanov, M.I.; Kulish, P.P.

1980-01-01

The class of exactly solvable nonlinear difference evolution equations (DEE) related to the discrete analog of the one-dimensional Dirac problem L is studied. For this starting from L we construct a special linear non-local operator Λ and obtain the expansions of w and σ 3 deltaw over its eigenfunctions, w being the potential in L. This allows us to obtain compact expressions for the integrals of motion and to prove that these DEE are completely integrable Hamiltonian systems. Moreover, it is shown that there exists a hierarchy of Hamiltonian structures, generated by Λ, and the action-angle variables are explicity calculated. As particular cases the difference analog of the non-linear Schroedinger equation and the modified Korteweg-de-Vries equation are considered. The quantization of these Hamiltonian system through the use of the quantum inverse scattering method is briefly discussed [ru

A 16 b 2 GHz digital-to-analog converter in 0.18 μm CMOS with digital calibration technology

International Nuclear Information System (INIS)

Yang Weidong; Pu Jie; Zhang Ruitao; Chen Chao; Zang Jiandong; Li Tiehu; Luo Pu

2015-01-01

This paper presents a 16-bit 2 GSPS digital-to-analog converter (DAC) in 0.18 μm CMOS technology. This DAC is implemented using time division multiplex access system architecture in the digital domain. The input data is received with a two-channel LVDS interface. The DLL technology is introduced to meet the timing requirements between phases of the LVDS data and the data sampling clock. A FIFO is designed to absorb the phase difference between the data clock and DAC system clock. A delay controller is integrated to adjust the phase relationship between the high speed digital clock and analog clock, obtaining a sampling rate of 2 GSPS. The current source mismatch at higher bits is calibrated in the digital domain. Test results show that the DAC achieves 74.02 dBC SFDR at analog output of 36 MHz, and DNL less than ±2.1 LSB and INL less than ±4.3 LSB after the chip is calibrated. (paper)

Global orbit feedback utilizing analog and digital technologies

International Nuclear Information System (INIS)

Singh, O.; Tang, Y.; Ramamoorthy, S.; Krinsky, S.; Yu, L.H.

1997-01-01

At the NSLS, an analog global orbit feedback system is used in regular operations, and a digital global orbit feedback system is available in machine physics studies on the X-Ray Ring. Here, the authors discuss the relative merits of utilizing analog and digital technology in orbit feedback. Results of experiments are reported characterizing the performance of the analog and digital systems when operated individually or together. They give their thoughts on plans for future development of the orbit feedback systems at the NSLS

Effects of Multimedia and Schema Induced Analogical Reasoning on Science Learning

Science.gov (United States)

Zheng, R. Z.; Yang, W.; Garcia, D.; McCadden, E. P.

2008-01-01

The present study investigates the effects of multimedia and schema induced analogical reasoning on science learning. It involves 89 fourth grade elementary students in the north-east of the United States. Participants are randomly assigned into four conditions: (a) multimedia with analogy; (b) multimedia without analogy; (c) analogy without…

Integrating holism and reductionism in the science of art perception.

Science.gov (United States)

Graham, Daniel J

2013-04-01

The contextualist claim that universalism is irrelevant to the proper study of art can be evaluated by examining an analogous question in neuroscience. Taking the reductionist-holist debate in visual neuroscience as a model, we see that the analog of orthodox contextualism is untenable, whereas integrated approaches have proven highly effective. Given the connection between art and vision, unified approaches are likewise more germane to the scientific study of art.

On Lovelock analogs of the Riemann tensor

Science.gov (United States)

Camanho, Xián O.; Dadhich, Naresh

2016-03-01

It is possible to define an analog of the Riemann tensor for Nth order Lovelock gravity, its characterizing property being that the trace of its Bianchi derivative yields the corresponding analog of the Einstein tensor. Interestingly there exist two parallel but distinct such analogs and the main purpose of this note is to reconcile both formulations. In addition we will introduce a simple tensor identity and use it to show that any pure Lovelock vacuum in odd d=2N+1 dimensions is Lovelock flat, i.e. any vacuum solution of the theory has vanishing Lovelock-Riemann tensor. Further, in the presence of cosmological constant it is the Lovelock-Weyl tensor that vanishes.

Development of an integrated filing system for endoscopic images.

Science.gov (United States)

Fujino, M A; Ikeda, M; Yamamoto, Y; Kinose, T; Tachikawa, H; Morozumi, A; Sano, S; Kojima, Y; Nakamura, T; Kawai, T

1991-01-01

A new integrated filing system for endoscopic images has been developed, comprising a main image filing system and subsystems located at different stations. A hybrid filing system made up of both digital and analog filing devices was introduced to construct this system that combines the merits of the two filing methods. Each subsystem provided with a video processor, is equipped with a digital filing device, and routine images were recorded in the analog image filing device of the main system. The use of a multi-input adapter enabled simultaneous input of analog images from up to 8 video processors. Recorded magneto-optical disks make it possible to recall the digital images at any station in the hospital; the disks are copied without image degradation and also utilised for image processing. This system promises reliable storage and integrated, efficient management of endoscopic information. It also costs less to install than the so-called PACS (picture archiving and communication system), which connects all the stations of the hospital using optical fiber cables.

Analogies in high school Brazilian chemistry textbooks

Directory of Open Access Journals (Sweden)

Rosária Justi

2000-05-01

Full Text Available This paper presents and discusses an analysis of the analogies presented by Brazilian chemistry textbooks for the medium level. The main aim of the analysis is to discuss whether such analogies can be said good teaching models. From the results, some aspects concerning with teachers' role are discussed. Finally, some new research questions are emphasised.

Analogy, an Alternative Model.
 Critics to the standard model of analogical problems solving and proposals for an alternative one

Directory of Open Access Journals (Sweden)

Ricardo A. Minervino

2016-02-01

Full Text Available The authors made an extension of Hofstadter‘s criticisms against the standard approach in analogical thinking represented by the structure-mapping theory of Gentner and the multiconstraint theory of Holyoak and Thagard. Based on this extension, they proposed a non-serial model of analogical problem solving. Against the standard approach, the model postulates that: (a people detect and evaluate differences between mapped elements before the subprocess of inference generation and consider them in order to control it, and (b properties of an element that explain why the element could fill a certain role in the base problem resolution (PERs play a crucial role in these detection and evaluation operations, and also in post-inferences subprocesses. An experiment showed that: (a people detect and evaluate the relevance of differences between mapped elements before inference generation, (b that they inhibit the generation of literal inferences when they face relevant differences, and (c that they stop the subprocess when they recognize insuperable ones. The results also showed that base PERs are reactivated at different moments of analogical transfer. The data obtained are incompatible with the standard theories of analogical thinking, which treat inference generation as a syntactic mechanism and exclude contextual semantic analysis from the study of analogy. 

The making of analog module for gamma camera interface

International Nuclear Information System (INIS)

Yulinarsari, Leli; Rl, Tjutju; Susila, Atang; Sukandar

2003-01-01

The making of an analog module for gamma camera has been conducted. For computerization of planar gamma camera 37 PMT it has been developed interface hardware technology and software between the planar gamma camera with PC. With this interface gamma camera image information (Originally analog signal) was changed to digital single, therefore processes of data acquisition, image quality increase and data analysis as well as data base processing can be conducted with the help of computers, there are three gamma camera main signals, i.e. X, Y and Z . This analog module makes digitation of analog signal X and Y from the gamma camera that conveys position information coming from the gamma camera crystal. Analog conversion to digital was conducted by 2 converters ADC 12 bit with conversion time 800 ns each, conversion procedure for each coordinate X and Y was synchronized using suitable strobe signal Z for information acceptance

Design of integrated all optical digital to analog converter (DAC) using 2D photonic crystals

Science.gov (United States)

Moniem, Tamer A.; El-Din, Eman S.

2017-11-01

A novel design of all optical 3 bit digital to analog (DAC) converter will be presented in this paper based on 2 Dimension photonic crystals (PhC). The proposed structure is based on the photonic crystal ring resonators (PCRR) with combining the nonlinear Kerr effect on the PCRR. The total size of the proposed optical 3 bit DAC is equal to 44 μm × 37 μm of 2D square lattice photonic crystals of silicon rods with refractive index equal to 3.4. The finite different time domain (FDTD) and Plane Wave Expansion (PWE) methods are used to back the overall operation of the proposed optical DAC.

Children's analogical reasoning in a third-grade science discussion

Science.gov (United States)

May, David B.; Hammer, David; Roy, Patricia

2006-03-01

Expert scientific inquiry involves the generation and use of analogies. How and when students might develop this aspect of expertise has implications for understanding how and when instruction might facilitate that development. In a study of K-8 student inquiry in physical science, we are examining cases of spontaneous analogy generation. In the case we present here, a third-grader generates an analogy and modifies it to reconcile his classmates' counterarguments, allowing us to identify in these third-graders specific aspects of nascent expertise in analogy use. Promoting abilities and inclinations such as these children display requires that educators recognize and respond to them.

Leibniz y el concepto de analogía

Directory of Open Access Journals (Sweden)

Oscar Miguel Esquisabel

2008-11-01

Full Text Available In this paper an analysis of the leibnizian applications of conceptof analogy as well as the analogical reasoning is approached. Thus, the analysis tries to show that the leibnizian concept of analogy is based on the idea of structural similarity. As a consequence of such consideration,two basic ways in which Leibniz applies analogical reasoning are examined. The first way has a conjectural character and is rather heuristic, whereas the second constitutes, at least in intention, a kind of demonstrative analogicalreasoning, since it tries to prove its conclusions for a determined theoreticaldomain by applying a transfer principle, which is itself founded on the identity of structural properties.This procedure is exemplified by outlining the leibnizian view on contingent truths. In this way, the paper concludesby pointing out the theoretical relevance of the concept of similarity in theleibnizian thought.

75 FR 16514 - Maxim Integrated Products, Formerly Known as Dallas Semiconductor, Dallas, TX; Amended...

Science.gov (United States)

2010-04-01

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-70,291] Maxim Integrated Products... Worker Adjustment Assistance on July 8th, 2009, applicable to workers of Maxim Integrated Products.... The workers produced integrated circuits (analog and mixed signal). Information shows that Maxim...

Active pixel sensor having intra-pixel charge transfer with analog-to-digital converter

Science.gov (United States)

Fossum, Eric R. (Inventor); Mendis, Sunetra K. (Inventor); Pain, Bedabrata (Inventor); Nixon, Robert H. (Inventor); Zhou, Zhimin (Inventor)

2003-01-01

An imaging device formed as a monolithic complementary metal oxide semiconductor integrated circuit in an industry standard complementary metal oxide semiconductor process, the integrated circuit including a focal plane array of pixel cells, each one of the cells including a photogate overlying the substrate for accumulating photo-generated charge in an underlying portion of the substrate, a readout circuit including at least an output field effect transistor formed in the substrate, and a charge coupled device section formed on the substrate adjacent the photogate having a sensing node connected to the output transistor and at least one charge coupled device stage for transferring charge from the underlying portion of the substrate to the sensing node and an analog-to-digital converter formed in the substrate connected to the output of the readout circuit.

The Discourse on Printed and Electronic Books: Analogies, Oppositions, and Perspectives

Science.gov (United States)

Velagic, Zoran

2014-01-01

Introduction: The point of departure for this paper is the twofold analogy (analogy of content, analogy of medium) between printed and electronic books, the aim being to draw attention to the usual perception of their capacities and relationships, to provide a rather detailed analysis of the outcome and sustainability of such analogies and…

Source selection for analogical reasoning an empirical approach

Energy Technology Data Exchange (ETDEWEB)

Stubblefield, W.A. [Sandia National Labs., Albuquerque, NM (United States); Luger, G.F. [Univ. of New Mexico, Albuquerque, NM (United States)

1996-12-31

The effectiveness of an analogical reasoner depends upon its ability to select a relevant analogical source. In many problem domains, however, too little is known about target problems to support effective source selection. This paper describes the design and evaluation of SCAVENGER, an analogical reasoner that applies two techniques to this problem: (1) An assumption-based approach to matching that allows properties of candidate sources to match unknown target properties in the absence of evidence to the contrary. (2) The use of empirical learning to improve memory organization based on problem solving experience.

Creative Analogy Use in a Heterogeneous Design Team

DEFF Research Database (Denmark)

Christensen, Bo; Ball, Linden J.

2016-01-01

the design dialogue derived from team members with highly disparate educational backgrounds. Our analyses revealed that analogies that matched (versus mismatched) educational backgrounds were generated and revisited more frequently, presumably because they were more accessible. Matching analogies were also...

Path integrals for arbitrary canonical transformations

International Nuclear Information System (INIS)

Oliveira, L.A.R. de.

1980-01-01

Some aspects of the path integral formulation of quantum mechanics are studied. This formalism is generalized to arbitrary canonical transformations, by means of an association between path integral probalility amplitudes and classical generators of transformations, analogous to the usual Hamiltonian time development phase space expression. Such association turns out to be equivalent to the Weyl quantization rule, and it is also shown that this formalism furnishes a path integral representation for a Lie algebra of a given set of classical generators. Some physical considerations about the path integral quantization procedure and about the relationship between classical and quantum dynamical structures are also discussed. (Author) [pt

An experimental device for characterizing degassing processes and related elastic fingerprints: Analog volcano seismo-acoustic observations

Science.gov (United States)

Spina, Laura; Morgavi, Daniele; Cannata, Andrea; Campeggi, Carlo; Perugini, Diego

2018-05-01

A challenging objective of modern volcanology is to quantitatively characterize eruptive/degassing regimes from geophysical signals (in particular seismic and infrasonic), for both research and monitoring purposes. However, the outcomes of the attempts made so far are still considered very uncertain because volcanoes remain inaccessible when deriving quantitative information on crucial parameters such as plumbing system geometry and magma viscosity. In order to improve our knowledge of volcanic systems, a novel experimental device, which is capable of mimicking volcanic degassing processes with different regimes and gas flow rates, and allowing for the investigation of the related seismo-acoustic emissions, was designed and developed. The benefits of integrating observations on real volcanoes with seismo-acoustic signals generated in laboratory are many and include (i) the possibility to fix the controlling parameters such as the geometry of the structure where the gas flows, the gas flow rate, and the fluid viscosity; (ii) the possibility of performing acoustic measurements at different azimuthal and zenithal angles around the opening of the analog conduit, hence constraining the radiation pattern of different acoustic sources; (iii) the possibility to measure micro-seismic signals in distinct points of the analog conduit; (iv) finally, thanks to the transparent structure, it is possible to directly observe the degassing pattern through the optically clear analog magma and define the degassing regime producing the seismo-acoustic radiations. The above-described device represents a step forward in the analog volcano seismo-acoustic measurements.

The neural basis of analogical reasoning: an event-related potential study.

Science.gov (United States)

Qiu, Jiang; Li, Hong; Chen, Antao; Zhang, Qinglin

2008-10-01

The spatiotemporal analysis of brain activation during the execution of easy analogy (EA) and difficult analogy (DA) tasks was investigated using high-density event-related brain potentials (ERPs). Results showed that reasoning tasks (schema induction) elicited a more negative ERP deflection (N500-1000) than did the baseline task (BS) between 500 and 1000 ms. Dipole source analysis of difference waves (EA-BS and DA-BS) indicated that the negative components were both localized near the left thalamus, possibly associated with the retrieval of alphabetical information. Furthermore, DA elicited a more positive ERP component (P600-1000) than did EA in the same time window. Two generators of P600-1000 were located in the medial prefrontal cortex (BA10) and the left frontal cortex (BA6) which was possibly involved in integrating information in schema abstraction. In the stage of analogy mapping, a greater negativity (N400-600) in the reasoning tasks as compared to BS was found over fronto-central scalp regions. A generator of this effect was located in the left fusiform gyrus and was possibly related to associative memory and activation of schema. Then, a greater negativity in the reasoning tasks, in comparison to BS task, developed between 900-1200 ms (LNC1) and 2000-2500 ms (LNC2). Dipole source analysis (EA-BS) localized the generator of LNC1 in the left prefrontal cortex (BA 10) which was possibly related to mapping the schema to the target problem, and the generator of LNC2 in the left prefrontal cortex (BA 9) which was possibly related to deciding whether a conclusion correctly follows from the schema.

Progress in the optoelectronic analog signal transfer for high energy particle detectors

International Nuclear Information System (INIS)

Tsang, T.; Radeka, V.

1992-05-01

We report the progress in the development of a radiation hard Optoelectronic analog system to transfer particle detector signals with high accuracy. We will present the motivation of this study, the operating principle of the optoelectronic system, the system noise study, the recent R ampersand D efforts on radiation effect, temperature stability, and the realization of an integrated l x l6 optical modulator. The issue of photon source for driving such a large-scale optoelectronic modulators is a major concern. We will address this problem by examining different possible photon sources and comment on other possible alternative for signal transfer

Military Importance of Natural Toxins and Their Analogs

Directory of Open Access Journals (Sweden)

Vladimír Pitschmann

2016-04-01

Full Text Available Toxin weapon research, development, production and the ban on its uses is an integral part of international law, with particular attention paid to the protection against these weapons. In spite of this, hazards associated with toxins cannot be completely excluded. Some of these hazards are also pointed out in the present review. The article deals with the characteristics and properties of natural toxins and synthetic analogs potentially constituting the basis of toxin weapons. It briefly describes the history of military research and the use of toxins from distant history up to the present age. With respect to effective disarmament conventions, it mentions certain contemporary concepts of possible toxin applications for military purposes and the protection of public order (suppression of riots; it also briefly refers to the question of terrorism. In addition, it deals with certain traditional as well as modern technologies of the research, synthesis, and use of toxins, which can affect the continuing development of toxin weapons. These are, for example, cases of new toxins from natural sources, their chemical synthesis, production of synthetic analogs, the possibility of using methods of genetic engineering and modern biotechnologies or the possible applications of nanotechnology and certain pharmaceutical methods for the effective transfer of toxins into the organism. The authors evaluate the military importance of toxins based on their comparison with traditional chemical warfare agents. They appeal to the ethics of the scientific work as a principal condition for the prevention of toxin abuse in wars, military conflicts, as well as in non-military attacks.

Military Importance of Natural Toxins and Their Analogs.

Science.gov (United States)

Pitschmann, Vladimír; Hon, Zdeněk

2016-04-28

Toxin weapon research, development, production and the ban on its uses is an integral part of international law, with particular attention paid to the protection against these weapons. In spite of this, hazards associated with toxins cannot be completely excluded. Some of these hazards are also pointed out in the present review. The article deals with the characteristics and properties of natural toxins and synthetic analogs potentially constituting the basis of toxin weapons. It briefly describes the history of military research and the use of toxins from distant history up to the present age. With respect to effective disarmament conventions, it mentions certain contemporary concepts of possible toxin applications for military purposes and the protection of public order (suppression of riots); it also briefly refers to the question of terrorism. In addition, it deals with certain traditional as well as modern technologies of the research, synthesis, and use of toxins, which can affect the continuing development of toxin weapons. These are, for example, cases of new toxins from natural sources, their chemical synthesis, production of synthetic analogs, the possibility of using methods of genetic engineering and modern biotechnologies or the possible applications of nanotechnology and certain pharmaceutical methods for the effective transfer of toxins into the organism. The authors evaluate the military importance of toxins based on their comparison with traditional chemical warfare agents. They appeal to the ethics of the scientific work as a principal condition for the prevention of toxin abuse in wars, military conflicts, as well as in non-military attacks.

Synthesis and anti-inflammatory activity of phenylbutenoid dimer analogs

International Nuclear Information System (INIS)

Kim, Sung Soo; Fang, Yuan Ying; Park, Hae Eil

2015-01-01

Several phenylbutenoid dimer (PBD) analogs were synthesized and evaluated for their inhibitory activities against nitric oxide (NO) production and TNF-α release. The PBD analogs were synthesized via Diels–Alder and subsequent Schlosser reactions as key steps. Among the tested compounds, two analogs (8c, 8f) exhibited much stronger inhibitory activity against LPS-stimulated NO production and TNF-α release in RAW 264.7 cells than that of wogonin

BERAS ANALOG SEBAGAI PANGAN FUNGSIONAL DENGAN INDEKS GLIKEMIK RENDAH

Directory of Open Access Journals (Sweden)

Santi Noviasari

2016-04-01

Full Text Available ABSTRACTThe objective of this research was to produce rice analogue as functional food with low glycemic index. The rice was made from white corn and sorghum with additional soybean flour. The physicochemical properties of rice analogue being analysed were resistant starch content, total phenolic content, dietary fiber, color (L*, +a, +b values and whiteness (oHue. Rice analogue was potentially used as functional food indicated by high level of resistant starch 2.59%-3.31%, total phenolic content 0.18-0.25 mg GAE/g sample and dietary fiber 5.35%-6.14%. Rice analogue from white corn with and without soybean flour was further tested for glycemic index. Rice analogue from white corn has 69 GI value, while rice analogue from white corn with 10% soybean flour addition has 50 GI value.Keywords: functional food, glycemic index, rice analogueABSTRAKTujuan penelitian ini adalah untuk mendapatkan beras analog yang berpotensi sebagai pangan fungsional dan bernilai indeks glikemik rendah. Beras analog dibuat dari bahan baku jagung putih dan sorgum dengan penambahan tepung kedelai. Sifat fisiko kimia beras analog yang dianalisis adalah pati resisten, total fenol, serat pangan, warna (nilai L*, +a, +b dan derajat putih (oHue. Beras analog berpotensi sebagai pangan fungsional, yang ditunjukkan dengan tingginya kadar pati resisten yaitu sebanyak 2,59%-3,31%, total fenol sekitar 0,18-0,25 mg GAE/g sampel dan serat pangan antara 5,35%-6,14%. Beras analog berbahan baku jagung putih dengan dan tanpa penambahan kedelai dipilih untuk uji indeks glikemik. Beras analog dari jagung putih memiliki nilai IG 69 sedangkan beras analog dari jagung putih dengan penambahan tepung kedelai 10% memiliki nilai IG 50.Kata kunci: beras analog, indeks glikemik, pangan fungsional

Nitrate analogs as attractants for soybean cyst nematode.

Science.gov (United States)

Hosoi, Akito; Katsuyama, Tsutomu; Sasaki, Yasuyuki; Kondo, Tatsuhiko; Yajima, Shunsuke; Ito, Shinsaku

2017-08-01

Soybean cyst nematode (SCN) Heterodera glycines Ichinohe, a plant parasite, is one of the most serious pests of soybean. In this paper, we report that SCN is attracted to nitrate and its analogs. We performed attraction assays to screen for novel attractants for SCN and found that nitrates were attractants for SCN and SCN recognized nitrate gradients. However, attraction of SCN to nitrates was not observed on agar containing nitrate. To further elucidate the attraction mechanism in SCN, we performed attraction assays using nitrate analogs ([Formula: see text], [Formula: see text], [Formula: see text]). SCN was attracted to all nitrate analogs; however, attraction of SCN to nitrate analogs was not observed on agar containing nitrate. In contrast, SCN was attracted to azuki root, irrespective of presence or absence of nitrate in agar media. Our results suggest that the attraction mechanisms differ between plant-derived attractant and nitrate.

Reference-Free CMOS Pipeline Analog-to-Digital Converters

CERN Document Server

Figueiredo, Michael; Evans, Guiomar

2013-01-01

This book shows that digitally assisted analog-to-digital converters are not the only way to cope with poor analog performance caused by technology scaling. It describes various analog design techniques that enhance the area and power efficiency without employing any type of digital calibration circuitry. These techniques consist of self-biasing for PVT enhancement, inverter-based design for improved speed/power ratio, gain-of-two obtained by voltage sum instead of charge redistribution, and current-mode reference shifting instead of voltage reference shifting. Together, these techniques allow enhancing the area and power efficiency of the main building blocks of a multiplying digital-to-analog converter (MDAC) based stage, namely, the flash quantizer, the amplifier, and the switched capacitor network of the MDAC. Complementing the theoretical analyses of the various techniques, a power efficient operational transconductance amplifier is implemented and experimentally characterized. Furthermore, a medium-low ...

ALMA 1.3 Millimeter Map of the HD 95086 System -- A Young Analog of the HR 8799 System

Science.gov (United States)

Su, Kate; MacGregor, Meredith Ann; Booth, Mark; Wilner, David; Malhotra, Renu; Morrison, Sarah; OST STDT

2018-01-01

Planets and minor bodies such as asteroids, Kuiper-belt objects and comets are integral components of a planetary system. Interactions among them leave clues about the formation process of a planetary system. The signature of such interactions is best illustrated through resolved observations of its debris disk. Here we present ALMA 1.3 mm observations of HD 95086, a young analog of the HR 8799 system, that hosts a directly imaged giant planet b and a massive debris disk with both asteroid- and Kuiper-belt analogs. The location of the Kuiper-belt analog is resolved for the first time. Our deep ALMA map also reveals a bright source located near the edge of the ring. The properties of the source, based on limited data, are consistent with it being a luminous star-forming galaxy at high redshift. We will discuss future, resolved observations of debris disks, highlighting the potential of the Origins Space Telescope (OST), one of the four science and technology definition studies commissioned by NASA Headquarters for the 2020 Astronomy and Astrophysics Decadal survey.

Event-Based Computation of Motion Flow on a Neuromorphic Analog Neural Platform.

Science.gov (United States)

Giulioni, Massimiliano; Lagorce, Xavier; Galluppi, Francesco; Benosman, Ryad B

2016-01-01

Estimating the speed and direction of moving objects is a crucial component of agents behaving in a dynamic world. Biological organisms perform this task by means of the neural connections originating from their retinal ganglion cells. In artificial systems the optic flow is usually extracted by comparing activity of two or more frames captured with a vision sensor. Designing artificial motion flow detectors which are as fast, robust, and efficient as the ones found in biological systems is however a challenging task. Inspired by the architecture proposed by Barlow and Levick in 1965 to explain the spiking activity of the direction-selective ganglion cells in the rabbit's retina, we introduce an architecture for robust optical flow extraction with an analog neuromorphic multi-chip system. The task is performed by a feed-forward network of analog integrate-and-fire neurons whose inputs are provided by contrast-sensitive photoreceptors. Computation is supported by the precise time of spike emission, and the extraction of the optical flow is based on time lag in the activation of nearby retinal neurons. Mimicking ganglion cells our neuromorphic detectors encode the amplitude and the direction of the apparent visual motion in their output spiking pattern. Hereby we describe the architectural aspects, discuss its latency, scalability, and robustness properties and demonstrate that a network of mismatched delicate analog elements can reliably extract the optical flow from a simple visual scene. This work shows how precise time of spike emission used as a computational basis, biological inspiration, and neuromorphic systems can be used together for solving specific tasks.

Memristor-Based Analog Computation and Neural Network Classification with a Dot Product Engine.

Science.gov (United States)

Hu, Miao; Graves, Catherine E; Li, Can; Li, Yunning; Ge, Ning; Montgomery, Eric; Davila, Noraica; Jiang, Hao; Williams, R Stanley; Yang, J Joshua; Xia, Qiangfei; Strachan, John Paul

2018-03-01

Using memristor crossbar arrays to accelerate computations is a promising approach to efficiently implement algorithms in deep neural networks. Early demonstrations, however, are limited to simulations or small-scale problems primarily due to materials and device challenges that limit the size of the memristor crossbar arrays that can be reliably programmed to stable and analog values, which is the focus of the current work. High-precision analog tuning and control of memristor cells across a 128 × 64 array is demonstrated, and the resulting vector matrix multiplication (VMM) computing precision is evaluated. Single-layer neural network inference is performed in these arrays, and the performance compared to a digital approach is assessed. Memristor computing system used here reaches a VMM accuracy equivalent of 6 bits, and an 89.9% recognition accuracy is achieved for the 10k MNIST handwritten digit test set. Forecasts show that with integrated (on chip) and scaled memristors, a computational efficiency greater than 100 trillion operations per second per Watt is possible. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

When Reasoning Modifies Memory: Schematic Assimilation Triggered by Analogical Mapping

Science.gov (United States)

Vendetti, Michael S.; Wu, Aaron; Rowshanshad, Ebi; Knowlton, Barbara J.; Holyoak, Keith J.

2014-01-01

Analogical mapping highlights shared relations that link 2 situations, potentially at the expense of information that does not fit the dominant pattern of correspondences. To investigate whether analogical mapping can alter subsequent recognition memory for features of a source analog, we performed 2 experiments with 4-term proportional analogies…

A heat exchanger analogy of automotive paint ovens

International Nuclear Information System (INIS)

Rao, Preetham P.

2013-01-01

Computational prediction of vehicle temperatures in an automotive paint oven is essential to predict paint quality and manufacturability. The complex geometry of vehicles, varying scales in the flow, transient nature of the process, and the tightly coupled conjugate heat transfer render the numerical models computationally very expensive. Here, a novel, simplified model of the oven is developed using an analogy to a three-stream cross flow heat exchanger that transfers heat from air to a series of moving bodies and supporting carriers. The analogous heat exchanger equations are developed and solved numerically. Steady state Computational Fluid Dynamics (CFD) simulations are carried out to model the flow field and to extract the heat transfer coefficients around the body and carriers. The air temperature distribution from the CFD models is used as a boundary condition in the analogous model. Correction coefficients are used in the analogy to take care of various assumptions. These are determined from existing test data. The same corrections are used to predict air temperatures for a modified configuration of the oven and a different vehicle. The method can be used to conduct control volume analysis of ovens to determine energy efficiency, and to study new vehicle or oven designs. -- Highlights: • Analogy of an automotive paint oven as a three stream cross flow heat exchanger. • The three streams are vehicle bodies, carriers and hot air. • Convection coefficients and inlet air stream temperatures from steady CFD simulations. • Analogy useful for overall energy efficiency analysis of conveyor ovens in general

Real-time compression of analog-to-digital converter outputs

International Nuclear Information System (INIS)

Okumura, Haruhiko

1997-01-01

We describe a fast lossless data compression algorithm suitable for digitized data taken at regular time intervals, such as outputs from analog-to-digital converters (ADCs). It is designed on the assumptions that the present value can be predicted approximately from the past values, and that the distribution of the prediction error is approximately Gaussian with zero mean and small and slowly changing standard deviation. Unlike many offline compression tools such as LHA and gzip, our algorithm does not need future values to encode the present value. This property is important for real-time transmission of compressed data on the network. The algorithm is to be integrated into our data acquisition system for the Large Helical Device (LHD) experiments at the National Institute for Fusion Science (NIFS). (author)

Analogical Reasoning in Children with Specific Language Impairment

Science.gov (United States)

Leroy, Sandrine; Parisse, Christophe; Maillart, Christelle

2012-01-01

Usage-based theory considers analogical reasoning as a cognitive process required in language development. We hypothesized that difficulties with analogical reasoning could hinder the abstraction of construction schemas, thus slowing down morphosyntactic development for children with specific language impairment (SLI). We also hypothesized, in…

Analogies in Medicine: Valuable for Learning, Reasoning, Remembering and Naming

Science.gov (United States)

Pena, Gil Patrus; Andrade-Filho, Jose de Souza

2010-01-01

Analogies are important tools in human reasoning and learning, for resolving problems and providing arguments, and are extensively used in medicine. Analogy and similarity involve a structural alignment or mapping between domains. This cognitive mechanism can be used to make inferences and learn new abstractions. Through analogies, we try to…

Spanish Velar-Insertion and Analogy: A Usage-Based Diachronic Analysis

Science.gov (United States)

Fondow, Steven Richard

2010-01-01

The theory of Analogical and Exemplar Modeling (AEM) suggests renewed discussion of the formalization of analogy and its possible incorporation in linguistic theory. AEM is a usage-based model founded upon Exemplar Modeling (Bybee 2007, Pierrehumbert 2001) that utilizes several principles of the Analogical Modeling of Language (Skousen 1992, 1995,…

FPGA implementation of a single-input fuzzy logic controller for boost converter with the absence of an external analog-to-digital converter

DEFF Research Database (Denmark)

Taeed, Fazel; Salam, Z.; Ayob, S.

2012-01-01

converter (ADC). Instead, a simple analog-to-digital conversion scheme is implemented using the FPGA itself. Due to the simplicity of the SIFLC algorithm and the absence of an external ADC, the overall implementation requires only 408 logic elements and five input-output pins of the FPGA.......) and applied on a 50-W boost converter. The SIFLC is compared to the proportional-integral controller; the simulation and practical results indicate that SIFLC exhibits excellent performance for step load and input reference changes. Another feature of this work is the absence of an external analog-to-digital...

Multilateral Research Opportunities in Ground Analogs

Science.gov (United States)

Corbin, Barbara J.

2015-01-01

The global economy forces many nations to consider their national investments and make difficult decisions regarding their investment in future exploration. International collaboration provides an opportunity to leverage other nations' investments to meet common goals. The Humans In Space Community shares a common goal to enable safe, reliable, and productive human space exploration within and beyond Low Earth Orbit. Meeting this goal requires efficient use of limited resources and International capabilities. The International Space Station (ISS) is our primary platform to conduct microgravity research targeted at reducing human health and performance risks for exploration missions. Access to ISS resources, however, is becoming more and more constrained and will only be available through 2020 or 2024. NASA's Human Research Program (HRP) is actively pursuing methods to effectively utilize the ISS and appropriate ground analogs to understand and mitigate human health and performance risks prior to embarking on human exploration of deep space destinations. HRP developed a plan to use ground analogs of increasing fidelity to address questions related to exploration missions and is inviting International participation in these planned campaigns. Using established working groups and multilateral panels, the HRP is working with multiple Space Agencies to invite International participation in a series of 30- day missions that HRP will conduct in the US owned and operated Human Exploration Research Analog (HERA) during 2016. In addition, the HRP is negotiating access to Antarctic stations (both US and non-US), the German :envihab and Russian NEK facilities. These facilities provide unique capabilities to address critical research questions requiring longer duration simulation or isolation. We are negotiating release of international research opportunities to ensure a multilateral approach to future analog research campaigns, hoping to begin multilateral campaigns in the

A CMOS integrated timing discriminator circuit for fast scintillation counters

International Nuclear Information System (INIS)

Jochmann, M.W.

1998-01-01

Based on a zero-crossing discriminator using a CR differentiation network for pulse shaping, a new CMOS integrated timing discriminator circuit is proposed for fast (t r ≥ 2 ns) scintillation counters at the cooler synchrotron COSY-Juelich. By eliminating the input signal's amplitude information by means of an analog continuous-time divider, a normalized pulse shape at the zero-crossing point is gained over a wide dynamic input amplitude range. In combination with an arming comparator and a monostable multivibrator this yields in a highly precise timing discriminator circuit, that is expected to be useful in different time measurement applications. First measurement results of a CMOS integrated logarithmic amplifier, which is part of the analog continuous-time divider, agree well with the corresponding simulations. Moreover, SPICE simulations of the integrated discriminator circuit promise a time walk well below 200 ps (FWHM) over a 40 dB input amplitude dynamic range

SSERVI Analog Regolith Simulant Testbed Facility

Science.gov (United States)

Minafra, J.; Schmidt, G. K.

2016-12-01

SSERVI's goals include supporting planetary researchers within NASA, other government agencies; private sector and hardware developers; competitors in focused prize design competitions; and academic sector researchers. The SSERVI Analog Regolith Simulant Testbed provides opportunities for research scientists and engineers to study the effects of regolith analog testbed research in the planetary exploration field. This capability is essential to help to understand the basic effects of continued long-term exposure to a simulated analog test environment. The current facility houses approximately eight tons of JSC-1A lunar regolith simulant in a test bin consisting of a 4 meter by 4 meter area. SSERVI provides a bridge between several groups, joining together researchers from: 1) scientific and exploration communities, 2) multiple disciplines across a wide range of planetary sciences, and 3) domestic and international communities and partnerships. This testbed provides a means of consolidating the tasks of acquisition, storage and safety mitigation in handling large quantities of regolith simulant Facility hardware and environment testing scenarios include, but are not limited to the following; Lunar surface mobility, Dust exposure and mitigation, Regolith handling and excavation, Solar-like illumination, Lunar surface compaction profile, Lofted dust, Mechanical properties of lunar regolith, and Surface features (i.e. grades and rocks) Numerous benefits vary from easy access to a controlled analog regolith simulant testbed, and planetary exploration activities at NASA Research Park, to academia and expanded commercial opportunities in California's Silicon Valley, as well as public outreach and education opportunities.

Neuroscientific Insights into the Development of Analogical Reasoning

Science.gov (United States)

Whitaker, Kirstie J.; Vendetti, Michael S.; Wendelken, Carter; Bunge, Silvia A.

2018-01-01

Analogical reasoning, or the ability to find correspondences between entities based on shared relationships, supports knowledge acquisition. As such, the development of this ability during childhood is thought to promote learning. Here, we sought to better understand the mechanisms by which analogical reasoning about semantic relations improves…

Cross-Domain Analogies as Relating Derived Relations among Two Separate Relational Networks

Science.gov (United States)

Ruiz, Francisco J; Luciano, Carmen

2011-01-01

Contemporary behavior analytic research is making headway in analyzing analogy as the establishment of a relation of coordination among common types of trained or derived relations. Previous studies have been focused on within-domain analogy. The current study expands previous research by analyzing cross-domain analogy as relating relations among separate relational networks and by correlating participants' performance with a standard measure of analogical reasoning. In two experiments, adult participants first completed general intelligence and analogical reasoning tests. Subsequently, they were exposed to a computerized conditional discrimination training procedure designed to create two relational networks, each consisting of two 3-member equivalence classes. The critical test was a two-part analogical test in which participants had to relate combinatorial relations of coordination and distinction between the two relational networks. In Experiment 1, combinatorial relations for each network were individually tested prior to analogical testing, but in Experiment 2 they were not. Across both experiments, 65% of participants passed the analogical test on the first attempt. Moreover, results from the training procedure were strongly correlated with the standard measure of analogical reasoning. PMID:21547072

MENUMBUHKAN DAYA NALAR ( POWER OF REASON SISWA MELALUI PEMBELAJARAN ANALOGI MATEMATIKA

Directory of Open Access Journals (Sweden)

Rahayu Kariadinata

2012-02-01

Full Text Available Learning mathematical analogy is one alternative learning that can be applied in order to cultivate the power of reason (power of reason students. Through mathematical analogy students are required to be able to look for similarities or relationship nature of the two concepts are the same or different by comparison, then draw a conclusion from the similitude. Thus the analogy can be used as an explanation or as the basis of reasoning. Before starting the analogy of learning mathematics, teachers should examine the ability of understanding mathematical concepts of students, because of the level of understanding of students will affect the power of reason. Tasks (problems mathematical analogy included non-routine matter, therefore the required readiness of teachers to make it. In each question contained mathematical analogy same or different concepts, so it takes quite a lot of material. Steps to make about the mathematical analogy, are: a assemble all the concepts in mathematics student has learned; b Similarly stacking properties / relationships contained in any concept, and c select materials that have a nature / relationship analogous. In this paper is given two forms of matter of mathematical analogy is the analogy of mathematical models and mathematical analogy 1 models 2. Learning mathematical analogy should be carried out after a number of concepts learned. It is better to be given in classes end for many of the concepts that have been learned by the students. Reasoning power (power of reason the student becomes an important part in the process of learning to drive them toward their future as citizens are intelligent, which will be led by the power of reason (the brain and not by the strength (muscle only. As noted by former US President Thomas Jefferson (in Copi, 1978: vii, which states: "In a republican nation, Whose citizens are to be led by reason and persuasion and not by force, the art of reasoning Becomes of first importance"

Software approach to automatic patching of analog computer

Science.gov (United States)

1973-01-01

The Automatic Patching Verification program (APV) is described which provides the hybrid computer programmer with a convenient method of performing a static check of the analog portion of his study. The static check insures that the program is patched as specified, and that the computing components being used are operating correctly. The APV language the programmer uses to specify his conditions and interconnections is similar to the FORTRAN language in syntax. The APV control program reads APV source program statements from an assigned input device. Each source program statement is processed immediately after it is read. A statement may select an analog console, set an analog mode, set a potentiometer or DAC, or read from the analog console and perform a test. Statements are read and processed sequentially. If an error condition is detected, an output occurs on an assigned output device. When an end statement is read, the test is terminated.

Mars for Earthlings: an analog approach to Mars in undergraduate education.

Science.gov (United States)

Chan, Marjorie; Kahmann-Robinson, Julia

2014-01-01

Mars for Earthlings (MFE) is a terrestrial Earth analog pedagogical approach to teaching undergraduate geology, planetary science, and astrobiology. MFE utilizes Earth analogs to teach Mars planetary concepts, with a foundational backbone in Earth science principles. The field of planetary science is rapidly changing with new technologies and higher-resolution data sets. Thus, it is increasingly important to understand geological concepts and processes for interpreting Mars data. MFE curriculum is topically driven to facilitate easy integration of content into new or existing courses. The Earth-Mars systems approach explores planetary origins, Mars missions, rocks and minerals, active driving forces/tectonics, surface sculpting processes, astrobiology, future explorations, and hot topics in an inquiry-driven environment. Curriculum leverages heavily upon multimedia resources, software programs such as Google Mars and JMARS, as well as NASA mission data such as THEMIS, HiRISE, CRISM, and rover images. Two years of MFE class evaluation data suggest that science literacy and general interest in Mars geology and astrobiology topics increased after participation in the MFE curriculum. Students also used newly developed skills to create a Mars mission team presentation. The MFE curriculum, learning modules, and resources are available online at http://serc.carleton.edu/marsforearthlings/index.html.

Analog lightwave links for detector front-ends at the LHC

International Nuclear Information System (INIS)

Baird, A.; Dowell, J.; Duthie, P.

1995-01-01

Lightwave links are being developed for volume application in the transfer of analog signals from the tracking detector front-ends to the readout electronics. The links are based on electro-optic intensity modulators which are mounted on detectors and connected by optical fibers to remotely located transceivers (lasers and photoreceivers). The modulators are 3--5 semiconductor reflective devices based on multi-quantum well structures. The transceivers will be integrated devices of a novel design. Modulator prototypes have been fabricated and tested. Neutron and γ-ray irradiation studies have been performed on modulators and fibers. The main results achieved so far are reported and key system issues are reviewed. This work is part of the CERN DRDC project RD23 project RD23

Natural analogs in the host rock salt. Pt. 1. General study (2011). Pt. 2. Detail studies (2012-2013); Natuerliche Analoga im Wirtsgestein Salz. T. 1. Generelle Studie (2011). T. 2. Detailstudien (2012-2013)

Energy Technology Data Exchange (ETDEWEB)

Brasser, Thomas; Fahrenholz, Christine; Kull, Herbert; Meleshyn, Artur; Moenig, Heike; Noseck, Ulrich; Schoenwiese, Dagmar; Wolf, Jens

2014-12-15

The first part of the project ISIBELII on natural analogs in the host rock salt included a summary of available studies on the topic to be used in a safety analysis for a final repository for heat generating radioactive waste. In 2012 the results of the preliminary safety analysis Gorleben was available, including results on the fracturing of anhydrite, the formation of cryogenic gaps and the influence of earthquakes. The requirements for the barrier system have been modified due to the safety requirements for the final disposal of heat-generating radioactive wastes valid since 2010. For containers the functionality gas to be demonstrated for 500 years. The following issues are covered: natural analogs for the integrity demonstration of the geological barrier, natural analogs for the integrity demonstration of geotechnical barriers, natural analogs for the evaluation of release scenarios. The detail studies include anhydrite fracturing, salt grit compaction, chemical composition of fluid inclusions, thermal stability of salt rock, mechanical stability of salt rock, influence of earthquakes, qualified closures, iron corrosion, and microbial processes.

Synthesis and structure-distribution study of radioiodinated norepinephrine storage analogs

Energy Technology Data Exchange (ETDEWEB)

Wieland, D.M.; Inbasekaran, M.; Brown, L.E.; Marsh, D.D.; Beierwaltes, W.H. (Michigan Univ., Ann Arbor (USA). Medical Center)

Unlabelled analogs of norepinephrine have been synthesised and then labelled with /sup 125/I in an attempt to find an agent with heart uptake and neuronal specificity greater than metaiodobenzylguanidine (MIBG). The analogs of norepinephrine were injected intravenously into dogs and showed a heart concentration similar to MIBG. Neuronal specificity of some analogs is being evaluated in rat heart.

How to Implement an Experimental Course on Analog IC design in a Standard Semester Schedule

DEFF Research Database (Denmark)

Jørgensen, Ivan Harald Holger; Marker-Villumsen, Niels

2013-01-01

how the sequences of courses in integrated analog electronics at the Technical University of Denmark have been modified to enable this. It is outlined how a course can be designed using the three elements in constructive alignment: intended learning objectives, teaching activities and assessment....... As an example it is described in detail how a new course is designed. The course is the first of two new courses and the scope of the course is to teach the students the flow an IC designer has to go through when designing analog circuits. Additionally the course has a large focus on strengthening the generic...... engineering competences of the students. This is achieved by running the course as a project in a company with status meetings and a review meeting where the teacher acts as a manager. Finally, the course evaluation based on the Course Evaluation Questionnaire (CEQ) is presented and based on this future...

Beuchot’s formal analogism within Peter Singer’s philosophy

Directory of Open Access Journals (Sweden)

José Barrientos-Rastrojo

2015-01-01

Full Text Available This paper analyses an analogic reading of singerian ethics. Firstly, it studies Mauricio Beuchot’s analogical hermeneutics grounds. Then, it takes them to each of the Peter Singer’s ethical universes. Finally, it reveals the scheme of his ethic that will be followed in his future works. Therefore, this article has a prospective mission related to Professor Singer and it has an practical mission related to Mauricio Beuchot because it determines a practical performance to his analogical hermeneutics.

A dark business, full of shadows: analogy and theology in William Harvey.

Science.gov (United States)

Goldberg, Benjamin

2013-09-01

In a short work called De conceptione appended to the end of his Exercitationes de generatione animalium (1651), William Harvey developed a rather strange analogy. To explain how such marvelous productions as living beings were generated from the rather inauspicious ingredients of animal reproduction, Harvey argued that conception in the womb was like conception in the brain. It was mostly rejected at the time; it now seems a ludicrous theory based upon homonymy. However, this analogy offers insight into the structure and function of analogies in early modern natural philosophy. In this essay I hope to not only describe the complex nature of Harvey's analogy, but also offer a novel interpretation of his use of analogical reasoning, substantially revising the account offered by Guido Giglioni (1993). I discuss two points of conceptual change and negotiation in connection with Harvey's analogy, understanding it as both a confrontation between the border of the natural and the supernatural, as well as a moment in the history of psychology. My interpretation touches upon a number of important aspects, including why the analogy was rejected, how Harvey systematically deployed analogies according to his notions of natural philosophical method, how the analogy fits into contemporary discussions of analogies in science, and finally, how the analogy must be seen in the context of changing Renaissance notions of the science of the soul, ultimately confronting the problem of how to understand final causality in Aristotelian science. In connection with the last, I conclude the essay by turning to how Harvey embeds the analogy within a natural theological cosmology. Copyright © 2013. Published by Elsevier Ltd.

Membrane Affinity of Platensimycin and Its Dialkylamine Analogs

Directory of Open Access Journals (Sweden)

Ian Rowe

2015-08-01

Full Text Available Membrane permeability is a desired property in drug design, but there have been difficulties in quantifying the direct drug partitioning into native membranes. Platensimycin (PL is a new promising antibiotic whose biosynthetic production is costly. Six dialkylamine analogs of PL were synthesized with identical pharmacophores but different side chains; five of them were found inactive. To address the possibility that their activity is limited by the permeation step, we calculated polarity, measured surface activity and the ability to insert into the phospholipid monolayers. The partitioning of PL and the analogs into the cytoplasmic membrane of E. coli was assessed by activation curve shifts of a re-engineered mechanosensitive channel, MscS, in patch-clamp experiments. Despite predicted differences in polarity, the affinities to lipid monolayers and native membranes were comparable for most of the analogs. For PL and the di-myrtenyl analog QD-11, both carrying bulky sidechains, the affinity for the native membrane was lower than for monolayers (half-membranes, signifying that intercalation must overcome the lateral pressure of the bilayer. We conclude that the biological activity among the studied PL analogs is unlikely to be limited by their membrane permeability. We also discuss the capacity of endogenous tension-activated channels to detect asymmetric partitioning of exogenous substances into the native bacterial membrane and the different contributions to the thermodynamic force which drives permeation.

Overview of the Human Exploration Research Analog (HERA)

Science.gov (United States)

Neigut, J.

2015-01-01

In 2013, the Human Research Program at NASA began developing a new confinement analog specifically for conducting research to investigate the effects of confinement on the human system. The HERA (Human Exploration Research Analog) habitat has been used for both 7 and 14 day missions to date to examine and mitigate exploration risks to enable safe, reliable and productive human space exploration. This presentation will describe how the Flight Analogs Project developed the HERA facility and the infrastructure to suit investigator requirements for confinement research and in the process developed a new approach to analog utilization and a new state of the art analog facility. Details regarding HERA operations will be discussed including specifics on the mission simulation utilized for the current 14-day campaign, the specifics of the facility (total volume, overall size, hardware), and the capabilities available to researchers. The overall operational philosophy, mission fidelity including timeline, schedule pressures and cadence, and development and implementation of mission stressors will be presented. Research conducted to date in the HERA has addressed risks associated with behavioral health and performance, human physiology, as well as human factors. This presentation will conclude with a discussion of future research plans for the HERA, including infrastructure improvements and additional research capabilities planned for the upcoming 30-day missions in 2016.

Reasoning through Instructional Analogies

Science.gov (United States)

Kapon, Shulamit; diSessa, Andrea A.

2012-01-01

This article aims to account for students' assessments of the plausibility and applicability of analogical explanations, and individual differences in these assessments, by analyzing properties of students' underlying knowledge systems. We developed a model of explanation and change in explanation focusing on knowledge elements that provide a…

Albert Einstein, Analogizer Extraordinaire

CERN Multimedia

CERN. Geneva

2007-01-01

Where does deep insight in physics come from? It is tempting to think that it comes from the purest and most precise of reasoning, following ironclad laws of thought that compel the clear mind completely rigidly. And yet the truth is quite otherwise. One finds, when one looks closely at any major discovery, that the greatest of physicists are, in some sense, the most crazily daring and irrational of all physicists. Albert Einstein exemplifies this thesis in spades. In this talk I will describe the key role, throughout Albert Einstein's fabulously creative life, played by wild guesses made by analogy lacking any basis whatsoever in pure reasoning. In particular, in this year of 2007, the centenary of 1907, I will describe how over the course of two years (1905 through 1907) of pondering, Einstein slowly came, via analogy, to understand the full, radical consequences of the equation that he had first discovered and published in 1905, arguably the most famous equation of all time: E = mc2.

Analog-to-digital conversion

CERN Document Server

Pelgrom, Marcel

2017-01-01

This textbook is appropriate for use in graduate-level curricula in analog-to-digital conversion, as well as for practicing engineers in need of a state-of-the-art reference on data converters. It discusses various analog-to-digital conversion principles, including sampling, quantization, reference generation, nyquist architectures and sigma-delta modulation. This book presents an overview of the state of the art in this field and focuses on issues of optimizing accuracy and speed, while reducing the power level. This new, third edition emphasizes novel calibration concepts, the specific requirements of new systems, the consequences of 22-nm technology and the need for a more statistical approach to accuracy. Pedagogical enhancements to this edition include additional, new exercises, solved examples to introduce all key, new concepts and warnings, remarks and hints, from a practitioner’s perspective, wherever appropriate. Considerable background information and practical tips, from designing a PCB, to lay-o...

Analog-to-digital conversion

CERN Document Server

Pelgrom, Marcel J. M

2013-01-01

This textbook is appropriate for use in graduate-level curricula in analog to digital conversion, as well as for practicing engineers in need of a state-of-the-art reference on data converters.  It discusses various analog-to-digital conversion principles, including sampling, quantization, reference generation, nyquist architectures and sigma-delta modulation.  This book presents an overview of the state-of-the-art in this field and focuses on issues of optimizing accuracy and speed, while reducing the power level. This new, second edition emphasizes novel calibration concepts, the specific requirements of new systems, the consequences of 45-nm technology and the need for a more statistical approach to accuracy.  Pedagogical enhancements to this edition include more than twice the exercises available in the first edition, solved examples to introduce all key, new concepts and warnings, remarks and hints, from a practitioner’s perspective, wherever appropriate.  Considerable background information and pr...

Terrestrial Spaceflight Analogs: Antarctica

Science.gov (United States)

Crucian, Brian

2013-01-01

Alterations in immune cell distribution and function, circadian misalignment, stress and latent viral reactivation appear to persist during Antarctic winterover at Concordia Station. Some of these changes are similar to those observed in Astronauts, either during or immediately following spaceflight. Others are unique to the Concordia analog. Based on some initial immune data and environmental conditions, Concordia winterover may be an appropriate analog for some flight-associated immune system changes and mission stress effects. An ongoing smaller control study at Neumayer III will address the influence of the hypoxic variable. Changes were observed in the peripheral blood leukocyte distribution consistent with immune mobilization, and similar to those observed during spaceflight. Alterations in cytokine production profiles were observed during winterover that are distinct from those observed during spaceflight, but potentially consistent with those observed during persistent hypobaric hypoxia. The reactivation of latent herpesviruses was observed during overwinter/isolation, that is consistently associated with dysregulation in immune function.

Synthesis and structure-distribution study of radioiodinated norepinephrine storage analogs

International Nuclear Information System (INIS)

Wieland, D.M.; Inbasekaran, M.; Brown, L.E.; Marsh, D.D.; Beierwaltes, W.H.

1982-01-01

Unlabelled analogs of norepinephrine have been synthesised and then labelled with 125 I in an attempt to find an agent with heart uptake and neuronal specificity greater than metaiodobenzylguanidine (MIBG). The analogs of norepinephrine were injected intravenously into dogs and showed a heart concentration similar to MIBG. Neuronal specificity of some analogs is being evaluated in rat heart. (U.K.)

The Development of Verbal Relations in Analogical Reasonings.

Science.gov (United States)

Sternberg, Robert J.; Nigro, Georgia

A six-process theory of analogical reasoning was tested by administering verbal analogy items to students in grades 3 through college. The items were classified according to five verbal relations: synonyms, antonyms, functional, linear ordering, and class membership. A new method of componential analysis that does not require precueing was used to…

Using Analogies to Prevent Misconceptions about Chemical Equilibrium

Science.gov (United States)

Sahin Pekmez, Esin

2010-01-01

The main purpose of this study was to find the effectiveness of using analogies to prevent misconceptions about chemical equilibrium. Nineteen analogies, which were based on dynamic aspects of chemical equilibrium and application of Le Chatelier's principle, were developed. The participations of this study consisted of 11th grade students (n: 151)…

Generation of multiple analog pulses with different duty cycles within VME control system for ICRH Aditya system

International Nuclear Information System (INIS)

Joshi, Ramesh; Singh, Manoj; Jadav, H M; Misra, Kishor; Kulkarni, S V

2010-01-01

Ion Cyclotron Resonance Heating (ICRH) is a promising heating method for a fusion device due to its localized power deposition profile, a direct ion heating at high density, and established technology for high RF power generation and transmission at low cost. Multiple analog pulse with different duty cycle in master of digital pulse for Data acquisition and Control system for steady state RF ICRH System(RF ICRH DAC) to be used for operating of RF Generator in Aditya to produce pre ionization and second analog pulse will produce heating. The control system software is based upon single digital pulse operation for RF source. It is planned to integrate multiple analog pulses with different duty cycle in master of digital pulse for Data acquisition and Control system for RF ICRH System(RF ICRH DAC) to be used for operating of RF Generator in Aditya tokamak. The task of RF ICRH DAC is to control and acquisition of all ICRH system operation with all control loop and acquisition for post analysis of data with java based tool. For pre ionization startup as well as heating experiments using multiple RF Power of different powers and duration. The experiment based upon the idea of using single RF generator to energize antenna inside the tokamak to radiate power twice, out of which first analog pulse will produce pre ionization and second analog pulse will produce heating. The whole system is based on standard client server technology using tcp/ip protocol. DAC Software is based on linux operating system for highly reliable, secure and stable system operation in failsafe manner. Client system is based on tcl/tk like toolkit for user interface with c/c++ like environment which is reliable programming languages widely used on stand alone system operation with server as vxWorks real time operating system like environment. The paper is focused on the Data acquisition and monitoring system software on Aditya RF ICRH System with analog pulses in slave mode with digital pulse in

Generation of multiple analog pulses with different duty cycles within VME control system for ICRH Aditya system

Science.gov (United States)

Joshi, Ramesh; Singh, Manoj; Jadav, H. M.; Misra, Kishor; Kulkarni, S. V.; ICRH-RF Group

2010-02-01

Ion Cyclotron Resonance Heating (ICRH) is a promising heating method for a fusion device due to its localized power deposition profile, a direct ion heating at high density, and established technology for high RF power generation and transmission at low cost. Multiple analog pulse with different duty cycle in master of digital pulse for Data acquisition and Control system for steady state RF ICRH System(RF ICRH DAC) to be used for operating of RF Generator in Aditya to produce pre ionization and second analog pulse will produce heating. The control system software is based upon single digital pulse operation for RF source. It is planned to integrate multiple analog pulses with different duty cycle in master of digital pulse for Data acquisition and Control system for RF ICRH System(RF ICRH DAC) to be used for operating of RF Generator in Aditya tokamak. The task of RF ICRH DAC is to control and acquisition of all ICRH system operation with all control loop and acquisition for post analysis of data with java based tool. For pre ionization startup as well as heating experiments using multiple RF Power of different powers and duration. The experiment based upon the idea of using single RF generator to energize antenna inside the tokamak to radiate power twise, out of which first analog pulse will produce pre ionization and second analog pulse will produce heating. The whole system is based on standard client server technology using tcp/ip protocol. DAC Software is based on linux operating system for highly reliable, secure and stable system operation in failsafe manner. Client system is based on tcl/tk like toolkit for user interface with c/c++ like environment which is reliable programming languages widely used on stand alone system operation with server as vxWorks real time operating system like environment. The paper is focused on the Data acquisition and monitoring system software on Aditya RF ICRH System with analog pulses in slave mode with digital pulse in

Generation of multiple analog pulses with different duty cycles within VME control system for ICRH Aditya system

Energy Technology Data Exchange (ETDEWEB)

Joshi, Ramesh; Singh, Manoj; Jadav, H M; Misra, Kishor; Kulkarni, S V, E-mail: rjoshi@ipr.res.i [Institute for plasma research, Bhat, Gandhinagar- 382428 (India)

2010-02-01

Ion Cyclotron Resonance Heating (ICRH) is a promising heating method for a fusion device due to its localized power deposition profile, a direct ion heating at high density, and established technology for high RF power generation and transmission at low cost. Multiple analog pulse with different duty cycle in master of digital pulse for Data acquisition and Control system for steady state RF ICRH System(RF ICRH DAC) to be used for operating of RF Generator in Aditya to produce pre ionization and second analog pulse will produce heating. The control system software is based upon single digital pulse operation for RF source. It is planned to integrate multiple analog pulses with different duty cycle in master of digital pulse for Data acquisition and Control system for RF ICRH System(RF ICRH DAC) to be used for operating of RF Generator in Aditya tokamak. The task of RF ICRH DAC is to control and acquisition of all ICRH system operation with all control loop and acquisition for post analysis of data with java based tool. For pre ionization startup as well as heating experiments using multiple RF Power of different powers and duration. The experiment based upon the idea of using single RF generator to energize antenna inside the tokamak to radiate power twice, out of which first analog pulse will produce pre ionization and second analog pulse will produce heating. The whole system is based on standard client server technology using tcp/ip protocol. DAC Software is based on linux operating system for highly reliable, secure and stable system operation in failsafe manner. Client system is based on tcl/tk like toolkit for user interface with c/c++ like environment which is reliable programming languages widely used on stand alone system operation with server as vxWorks real time operating system like environment. The paper is focused on the Data acquisition and monitoring system software on Aditya RF ICRH System with analog pulses in slave mode with digital pulse in

Soil Structure Interaction for Integral Abutment Bridge Using Spring Analogy Approach

International Nuclear Information System (INIS)

Thanoon, W A; Abdulrazeg, A A; Jaafar, M S; Kohnehpooshi, O; Noorzaei, J

2011-01-01

The reaction of the backfill behind the abutments and adjacent to the piles plays a significant role in the behavior of the Integral bridge. The handling of soil-structure interaction in the analysis and design of integral abutment bridges has always been problematic due to its complexity. This study describes the implementation of a 2-D finite element model of IAB system which explicitly incorporates the soil response. The superstructure members and the pile have been represented by means of three-node isoperimetric beam elements with three degree of freedom per node. The Eight node isoperimetric quadrilateral element has been used to model the abutment. The backfill was idealized by uncoupled 'Winkler' spring. The applic1ability of this model is demonstrated by analyzing a single span IA bridge. The results have shown that the shear forces at the tops of the supported piles were only 12% to 16% of the load which at the top of abutment.

Soil Structure Interaction for Integral Abutment Bridge Using Spring Analogy Approach

Energy Technology Data Exchange (ETDEWEB)

Thanoon, W A [Faculty Engineering, Nizwa University (Oman); Abdulrazeg, A A; Jaafar, M S; Kohnehpooshi, O [Department of Civil Engineering, University Putra Malaysia, 43400 Serdang, Selangor (Malaysia); Noorzaei, J, E-mail: jamal@eng.upm.edu.my [Institute of Advance Technology, University Putra Malaysia, 43400 Serdang, Selangor (Malaysia)

2011-02-15

The reaction of the backfill behind the abutments and adjacent to the piles plays a significant role in the behavior of the Integral bridge. The handling of soil-structure interaction in the analysis and design of integral abutment bridges has always been problematic due to its complexity. This study describes the implementation of a 2-D finite element model of IAB system which explicitly incorporates the soil response. The superstructure members and the pile have been represented by means of three-node isoperimetric beam elements with three degree of freedom per node. The Eight node isoperimetric quadrilateral element has been used to model the abutment. The backfill was idealized by uncoupled 'Winkler' spring. The applic1ability of this model is demonstrated by analyzing a single span IA bridge. The results have shown that the shear forces at the tops of the supported piles were only 12% to 16% of the load which at the top of abutment.

Analysis of Recurrent Analog Neural Networks

Directory of Open Access Journals (Sweden)

Z. Raida

1998-06-01

Full Text Available In this paper, an original rigorous analysis of recurrent analog neural networks, which are built from opamp neurons, is presented. The analysis, which comes from the approximate model of the operational amplifier, reveals causes of possible non-stable states and enables to determine convergence properties of the network. Results of the analysis are discussed in order to enable development of original robust and fast analog networks. In the analysis, the special attention is turned to the examination of the influence of real circuit elements and of the statistical parameters of processed signals to the parameters of the network.

Analogy Mapping Development for Learning Programming

Science.gov (United States)

Sukamto, R. A.; Prabawa, H. W.; Kurniawati, S.

2017-02-01

Programming skill is an important skill for computer science students, whereas nowadays, there many computer science students are lack of skills and information technology knowledges in Indonesia. This is contrary with the implementation of the ASEAN Economic Community (AEC) since the end of 2015 which is the qualified worker needed. This study provided an effort for nailing programming skills by mapping program code to visual analogies as learning media. The developed media was based on state machine and compiler principle and was implemented in C programming language. The state of every basic condition in programming were successful determined as analogy visualization.

Data input from an analog-to-digital converter into the M-6000 computer

International Nuclear Information System (INIS)

Kalashnikov, A.M.; Sheremet'ev, A.K.

1978-01-01

A device for spectrometric data input from the ADC-4096 into the M-6000 computer memory operating in the information storage regime is described. The input device made on integrated circuits coordinates signal levels of the fast response analog-to-digital converter and computer with the help of resistors and inverters. Besides, the input forms a strobe to trigger an increment channel used to record information into the computer memory. The use of the input device permits to get rid of the intermediate information storage in the analyzer memory and ensures fast response of the devices

Analogical study of the servo-control of a reactivity modulator

International Nuclear Information System (INIS)

Le Bot, Michel

1969-03-01

In the context of the study of the transfer functions related to the Cabri reactor, this paper presents: the objective of the servo-control (reactivity modulator, reasons for the analogical study), the principles of the servo-control (description of the servo-controlled system, elaboration of the error signal, principles of the phase meter, critical analysis of different types of phase meters), the analogical formulation (transfer diagram of the process, analogical simulation of the process, analogical realization of the phase meter, simulation of the Low Frequency generator), study of the controlled system and results (system responses to echelon and ramp signals, responses of the controlled system with the phase meter in feedback)

Acoustic analog computing based on a reflective metasurface with decoupled modulation of phase and amplitude

Science.gov (United States)

Zuo, Shu-Yu; Tian, Ye; Wei, Qi; Cheng, Ying; Liu, Xiao-Jun

2018-03-01

The use of metasurfaces has allowed the provision of a variety of functionalities by ultrathin structures, paving the way toward novel highly compact analog computing devices. Here, we conceptually realize analog computing using an acoustic reflective computational metasurface (RCM) that can independently manipulate the reflection phase and amplitude of an incident acoustic signal. This RCM is composed of coating unit cells and perforated panels, where the first can tune the transmission phase within the full range of 2π and the second can adjust the reflection amplitude in the range of 0-1. We show that this RCM can achieve arbitrary reflection phase and amplitude and can be used to realize a unique linear spatially invariant transfer function. Using the spatial Fourier transform (FT), an acoustic analog computing (AAC) system is proposed based on the RCM together with a focusing lens. Based on numerical simulations, we demonstrate that this AAC system can perform mathematical operations such as spatial differentiation, integration, and convolution on an incident acoustic signal. The proposed system has low complexity and reduced size because the RCM is able to individually adjust the reflection phase and amplitude and because only one block is involved in performing the spatial FT. Our work may offer a practical, efficient, and flexible approach to the design of compact devices for acoustic computing applications, signal processing, equation solving, and acoustic wave manipulations.

VME Switch for CERN's PS Analog Video System

CERN Document Server

Acebes, I; Heinze, W; Lewis, J; Serrano, J

2003-01-01

Analog video signal switching is used in CERN's Proton Synchrotron (PS) complex to route the video signals coming from Beam Diagnostics systems to the Meyrin Control Room (MCR). Traditionally, this has been done with custom electromechanical relay-based cards controlled serially via CAMAC crates. In order to improve the robustness and maintainability of the system, while keeping it analog to preserve the low latency, a VME card based on Analog Devices' AD8116 analog matrix chip has been developed. Video signals go into the front panel and exit the switch through the P2 connector of the VME backplane. The module is a 16 input, 32 output matrix. Larger matrices can be built using more modules and bussing their outputs together, thanks to the high impedance feature of the AD8116. Another VME module takes the selected signals from the P2 connector and performs automatic gain to send them at nominal output level through its front panel. This paper discusses both designs and presents experimental test results.

Analogical reasoning in a capuchin monkey (Cebus apella).

Science.gov (United States)

Kennedy, Erica Hoy; Fragaszy, Dorothy M

2008-05-01

Previous evidence has suggested that analogical reasoning (recognizing similarities among object relations when the objects themselves are dissimilar) is limited to humans and apes. This study investigated whether capuchin monkeys (Cebus apella) can use analogical reasoning to solve a 3-dimensional search task. The task involved hiding a food item under 1 of 2 or 3 plastic cups of different sizes and then allowing subjects to search for food hidden under the cup of analogous size in their own set of cups. Four monkeys were exposed to a series of relational matching tasks. If subjects reached criterion on these tasks, they were exposed to relational transfer tasks involving novel stimuli. Three of the monkeys failed to reach criterion on the basic relational matching tasks and therefore were not tested further. One monkey, however, revealed above-chance performance on a series of transfer tasks with 3 novel stimuli. This evidence suggests that contrary to previous arguments, a member of a New World monkey species can solve an analogical problem. PsycINFO Database Record (c) 2008 APA, all rights reserved.

Community Decadal Panel for Terrestrial Analogs to Mars

Science.gov (United States)

Barlow, N. G.; Farr, T.; Baker, V. R.; Bridges, N.; Carsey, F.; Duxbury, N.; Gilmore, M. S.; Green, J. R.; Grin, E.; Hansen, V.; Keszthelyi, L.; Lanagan, P.; Lentz, R.; Marinangeli, L.; Morris, P. A.; Ori, G. G.; Paillou, P.; Robinson, C.; Thomson, B.

2001-11-01

It is well recognized that interpretations of Mars must begin with the Earth as a reference. The most successful comparisons have focused on understanding geologic processes on the Earth well enough to extrapolate to Mars' environment. Several facets of terrestrial analog studies have been pursued and are continuing. These studies include field workshops, characterization of terrestrial analog sites for Mars, instrument tests, laboratory measurements (including analysis of martian meteorites), and computer and laboratory modeling. The combination of all these activities allows scientists to constrain the processes operating in specific terrestrial environments and extrapolate how similar processes could affect Mars. The Terrestrial Analogs for Mars Community Panel is considering the following two key questions: (1) How do terrestrial analog studies tie in to the MEPAG science questions about life, past climate, and geologic evolution of Mars, and (2) How can future instrumentation be used to address these questions. The panel is considering the issues of data collection, value of field workshops, data archiving, laboratory measurements and modeling, human exploration issues, association with other areas of solar system exploration, and education and public outreach activities.

Antimicrobial and cell-penetrating properties of penetratin analogs

DEFF Research Database (Denmark)

Bahnsen, Jesper Søborg; Franzyk, Henrik; Sandberg-Schaal, Anne

2013-01-01

Cell-penetrating peptides (CPPs) and antimicrobial peptides (AMPs) show great potential as drug delivery vectors and new antibiotic drug entities, respectively. The current study deals with the properties of a variety of peptide analogs derived from the well-known CPP penetratin as well as octaar......Cell-penetrating peptides (CPPs) and antimicrobial peptides (AMPs) show great potential as drug delivery vectors and new antibiotic drug entities, respectively. The current study deals with the properties of a variety of peptide analogs derived from the well-known CPP penetratin as well...... as octaarginine and different Tat sequences. The effects of peptide length, guanidinium content, and sequence of non-cationic residues were assessed in mammalian and bacterial cells. The arginine (Arg) content in the penetratin analogs was found to influence eukaryotic cell uptake efficiency, antimicrobial...... was similar, the eukaryotic cellular uptake of the shuffled analogs was noticeably lower than for native penetratin. Moreover, a point substitution of Met to Leu in native penetratin had no influence on eukaryotic cellular uptake and antimicrobial effect, and only a minor effect on cytotoxicity, in contrast...

The use of analogies in forecasting ecological and societal responses to global warming

Energy Technology Data Exchange (ETDEWEB)

Glantz, M.H. (National Center for Atmospheric Research, Boulder CO (USA). Environmental Research and Societal Impacts Group)

1991-06-01

Due to the limitations of general circulation models, researchers use analogies to look at future climatic change and its effects. Analogies used include the greenhouse, the Altithermal period, regional climates and summertime. Analogical reasoning is a prominent part of general circulation modeling of the atmosphere. Analogies are useful for generating hypotheses and improving understanding, but not as forecasts. The use of an analogy to develop specific policies related to global warming is risky. Historical analogies can provide a first approach to ascertaining the level of societal preparedness for the impacts of a global warming. Each analogy provides additional information about the target problem. 63 refs., 3 figs., 1 tab.

The use of analogies in forecasting ecological and societal responses to global warming

International Nuclear Information System (INIS)

Glantz, M.H.

1991-01-01

Due to the limitations of general circulation models, researchers use analogies to look at future climatic change and its effects. Analogies used include the greenhouse, the Altithermal period, regional climates and summertime. Analogical reasoning is a prominent part of general circulation modeling of the atmosphere. Analogies are useful for generating hypotheses and improving understanding, but not as forecasts. The use of an analogy to develop specific policies related to global warming is risky. Historical analogies can provide a first approach to ascertaining the level of societal preparedness for the impacts of a global warming. Each analogy provides additional information about the target problem. 63 refs., 3 figs., 1 tab

Electrostatic analogy for symmetron gravity

Science.gov (United States)

Ogden, Lillie; Brown, Katherine; Mathur, Harsh; Rovelli, Kevin

2017-12-01

The symmetron model is a scalar-tensor theory of gravity with a screening mechanism that suppresses the effect of the symmetron field at high densities characteristic of the Solar System and laboratory scales but allows it to act with gravitational strength at low density on the cosmological scale. We elucidate the screening mechanism by showing that in the quasistatic Newtonian limit there are precise analogies between symmetron gravity and electrostatics for both strong and weak screening. For strong screening we find that large dense bodies behave in a manner analogous to perfect conductors in electrostatics. Based on this analogy we find that the symmetron field exhibits a lightning rod effect wherein the field gradients are enhanced near the ends of pointed or elongated objects. An ellipsoid placed in a uniform symmetron gradient is shown to experience a torque. By symmetry there is no gravitational torque in this case. Hence this effect unmasks the symmetron and might serve as the basis for future laboratory experiments. The symmetron force between a point mass and a large dense body includes a component corresponding to the interaction of the point mass with its image in the larger body. None of these effects have counterparts in the Newtonian limit of Einstein gravity. We discuss the similarities between symmetron gravity and the chameleon model as well as the differences between the two.

Introduction to engineering a starter's guide with hands-on analog multimedia explorations

CERN Document Server

Karam, Lina

2008-01-01

This lecture provides a hands-on glimpse of the field of electrical engineering. The introduced applications utilize the NI ELVIS hardware and software platform to explore concepts such as circuits, power, analog sensing, and introductory analog signal processing such as signal generation, analog filtering, and audio and music processing. These principals and technologies are introduced in a very practical way and are fundamental to many of the electronic devices we use today. Some examples include photodetection, analog signal (audio, light, temperature) level meter, and analog music equalize

The Description of Problems Relating to Analogies Used in Science and Technology Textbooks

Directory of Open Access Journals (Sweden)

Rahmi YAĞBASAN

2008-01-01

Full Text Available The aim of this study was to determine the problems concerning the use of analogies ingeneral and analogies used in primary school science and technology lessons inparticular. In this study, descriptive method was used. 4th, 5th, and 8th classes Scienceand Technology course books; 7 th, 8 th classes Science Books were used as a source.Analogies in the course books were classified according to the literature and theproblems found related to the analogies are pointed out in the study. In this study itwas seen that eighty-nine analogies were used in Science and Technology and inScience course books. These analogies were used in descending order as 8, 4, 6, 7, 5class groups. Also it was seen that these analogies were generally at simple andpictorial analogies.

A digital calibration technique for an ultra high-speed wide-bandwidth folding and interpolating analog-to-digital converter in 0.18-{mu}m CMOS technology

Energy Technology Data Exchange (ETDEWEB)

Yu Jinshan; Zhang Ruitao; Zhang Zhengping; Wang Yonglu; Zhu Can; Zhang Lei; Yu Zhou; Han Yong, E-mail: yujinshan@yeah.net [National Laboratory of Analog IC' s, Chongqing 400060 (China)

2011-01-15

A digital calibration technique for an ultra high-speed folding and interpolating analog-to-digital converter in 0.18-{mu}m CMOS technology is presented. The similar digital calibration techniques are taken for high 3-bit flash converter and low 5-bit folding and interpolating converter, which are based on well-designed calibration reference, calibration DAC and comparators. The spice simulation and the measured results show the ADC produces 5.9 ENOB with calibration disabled and 7.2 ENOB with calibration enabled for high-frequency wide-bandwidth analog input. (semiconductor integrated circuits)

Associative memory in an analog iterated-map neural network

Science.gov (United States)

Marcus, C. M.; Waugh, F. R.; Westervelt, R. M.

1990-03-01

The behavior of an analog neural network with parallel dynamics is studied analytically and numerically for two associative-memory learning algorithms, the Hebb rule and the pseudoinverse rule. Phase diagrams in the parameter space of analog gain β and storage ratio α are presented. For both learning rules, the networks have large ``recall'' phases in which retrieval states exist and convergence to a fixed point is guaranteed by a global stability criterion. We also demonstrate numerically that using a reduced analog gain increases the probability of recall starting from a random initial state. This phenomenon is comparable to thermal annealing used to escape local minima but has the advantage of being deterministic, and therefore easily implemented in electronic hardware. Similarities and differences between analog neural networks and networks with two-state neurons at finite temperature are also discussed.

Some aspects of analogical reasoning in mathematical creativity

OpenAIRE

Pease, Alison; Guhe, Markus; Smaill, Alan

2010-01-01

Analogical reasoning can shed light on both of the two key processes of creativity– generation and evaluation. Hence, it is a powerful tool for creativity. We illustrate this with three historical case studies of creative mathematical conjectures which were either found or evaluated via analogies. We conclude by describing our ongoing efforts to build computational realisations of these ideas.

Functional-integral formulations for plasma instabilities and turbulence; analogies with phase-transition phenomena

International Nuclear Information System (INIS)

Arnold, R.C.

1977-06-01

The formalism of Martin, Siggia and Rose is utilized to write a functional-integral representation for generating functionals in plasma transport theory, following Nakayama and Dawson. Parallel treatments of Navier-Stokes turbulence (attempted by Rosen) and of critical dynamics, by Kawasaki, are compared to illustrate the application of common field-theory techniques, such as the effective action. Quasi-classical methods for functional integrals are discussed

Analogies as Creative Inspiration Sources in the Design Studio : The Teamwork

NARCIS (Netherlands)

Casakin, H.; Van Timmeren, A.

2014-01-01

Analogical reasoning can be seen as an important aid in problem solving, and architectural design problem solving in particular. Analogical reasoning was found to be an important aid supporting architectural education. In this paper we explored the use of visual and verbal analogies in the early

C–H-Functionalization logic guides the synthesis of a carbacyclopamine analog

Directory of Open Access Journals (Sweden)

Sebastian Rabe

2014-07-01

Full Text Available The chemical synthesis of carbacyclopamine analog 2, a cyclopamine analog with an all-carbon E-ring, is reported. The use of C–H-functionalization logic and further metal-catalyzed transformations allows for a concise entry to this new class of acid-stable cyclopamine analogs.

Analogy as a strategy for supporting complex problem solving under uncertainty.

Science.gov (United States)

Chan, Joel; Paletz, Susannah B F; Schunn, Christian D

2012-11-01

Complex problem solving in naturalistic environments is fraught with uncertainty, which has significant impacts on problem-solving behavior. Thus, theories of human problem solving should include accounts of the cognitive strategies people bring to bear to deal with uncertainty during problem solving. In this article, we present evidence that analogy is one such strategy. Using statistical analyses of the temporal dynamics between analogy and expressed uncertainty in the naturalistic problem-solving conversations among scientists on the Mars Rover Mission, we show that spikes in expressed uncertainty reliably predict analogy use (Study 1) and that expressed uncertainty reduces to baseline levels following analogy use (Study 2). In addition, in Study 3, we show with qualitative analyses that this relationship between uncertainty and analogy is not due to miscommunication-related uncertainty but, rather, is primarily concentrated on substantive problem-solving issues. Finally, we discuss a hypothesis about how analogy might serve as an uncertainty reduction strategy in naturalistic complex problem solving.

Analogical processes in children's understanding of spatial representations.

Science.gov (United States)

Yuan, Lei; Uttal, David; Gentner, Dedre

2017-06-01

We propose that map reading can be construed as a form of analogical mapping. We tested 2 predictions that follow from this claim: First, young children's patterns of performance in map reading tasks should parallel those found in analogical mapping tasks; and, second, children will benefit from guided alignment instructions that help them see the relational correspondences between the map and the space. In 4 experiments, 3-year-olds completed a map reading task in which they were asked to find hidden objects in a miniature room, using a corresponding map. We manipulated the availability of guided alignment (showing children the analogical mapping between maps and spaces; Experiments 1, 2, and 3a), the format of guided alignment (gesture or relational language; Experiment 2), and the iconicity of maps (Experiments 3a and 3b). We found that (a) young children's difficulties in map reading follow from known patterns of analogical development-for example, focusing on object similarity over relational similarity; and (b) guided alignment based on analogical reasoning led to substantially better performance. Results also indicated that children's map reading performance was affected by the format of guided alignment, the iconicity of the maps, and the order of tasks. The results bear on the developmental mechanisms underlying young children's learning of spatial representations and also suggest ways to support this learning. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

IADE: a system for intelligent automatic design of bioisosteric analogs

Science.gov (United States)

Ertl, Peter; Lewis, Richard

2012-11-01

IADE, a software system supporting molecular modellers through the automatic design of non-classical bioisosteric analogs, scaffold hopping and fragment growing, is presented. The program combines sophisticated cheminformatics functionalities for constructing novel analogs and filtering them based on their drug-likeness and synthetic accessibility using automatic structure-based design capabilities: the best candidates are selected according to their similarity to the template ligand and to their interactions with the protein binding site. IADE works in an iterative manner, improving the fitness of designed molecules in every generation until structures with optimal properties are identified. The program frees molecular modellers from routine, repetitive tasks, allowing them to focus on analysis and evaluation of the automatically designed analogs, considerably enhancing their work efficiency as well as the area of chemical space that can be covered. The performance of IADE is illustrated through a case study of the design of a nonclassical bioisosteric analog of a farnesyltransferase inhibitor—an analog that has won a recent "Design a Molecule" competition.

Componential Analysis of Analogical-Reasoning Performance of High and Low Achievers.

Science.gov (United States)

Armour-Thomas, Eleanor; Allen, Brenda A.

1990-01-01

Assessed analogical reasoning in high- and low-achieving students at the high school level and determined whether analogical reasoning was related to academic achievement in ninth grade students (N=54). Results indicated that high achievers performed better than low achievers on all types of analogical-reasoning processes. (Author/ABL)

Final report of the AECL/SKB Cigar Lake analog study

International Nuclear Information System (INIS)

Cramer, J.

1994-05-01

The Cigar Lake uranium deposit is located in northern Saskatchewan, Canada. The 1.3-billion-year-old deposit is located at a depth of about 450 m below surface in a water-saturated sandstone at the unconformity contact with the high-grade metamorphic rocks of the Canadian Shield. The Cigar Lake deposit has many features that parallel those being considered within the Canadian concept for disposal of nuclear fuel waste. The study of these natural structures and processes provides valuable insight toward the eventual design and site selection of a nuclear fuel waste repository. The main feature of this analog is the absence of any indication on the surface of the rich uranium ore 450 m below. This indicates that the combination of natural barriers has been effective in isolating the uranium ore from the surface environment. More specifically, the deposit provides analog information relevant to the stability of UO 2 fuel waste, the performance of clay-based barriers, radionuclide migration, colloid formation, radiolysis, fission-product geochemistry and general aspects of water-rock interaction. The main geochemical studies on this deposit focus on the evolution of groundwater compositions in the deposit and on their redox chemistry with respect to the uranium, iron and sulphide systems. Since 1984, through cooperation from the owners of the Cigar Lake deposit, analog studies have been conducted. AECL, with support from Ontario Hydro under the auspices of the CANDU Owners Group, initiated international participation in 1989 through collaboration with the Swedish Nuclear Fuel and Waste Management Company (SKB) and, more recently, with the Los Alamos National Laboratory (LANL). This report gives the results of the various studies carried out during the 3-year collaboration between AECL and SKB, as well as a summery of the LANL study. It provides detailed information on the generated databases and models, and integrates this information into conclusions for use in safety

An fMRI investigation of cognitive stages in reasoning by analogy.

Science.gov (United States)

Krawczyk, Daniel C; McClelland, M Michelle; Donovan, Colin M; Tillman, Gail D; Maguire, Mandy J

2010-06-25

We compared reasoning about four-term analogy problems in the format (A:B::C: D) to semantic and perceptual control conditions that required matching without analogical mapping. We investigated distinct phases of the problem solving process divided into encoding, mapping/inference, and response. Using fMRI, we assessed the brain activation relevant to each of these phases with an emphasis on achieving a better understanding of analogical reasoning relative to these other matching conditions. We predicted that the analogical condition would involve the most cognitive effort in the encoding and mapping/inference phases, while the control conditions were expected to engage greater prefrontal cortex (PFC) activation at the response period. Results showed greater activation for the analogical condition relative to the control conditions at the encoding phase in several predominantly left lateralized and medial areas of the PFC. Similar results were observed for the mapping/inference phase, though this difference was limited to the left PFC and rostral PFC. The response phase resulted in the fastest and most accurate responses in the analogy condition relative to the control conditions. This was accompanied by greater processing within the left lateral and the medial PFC for the control conditions relative to the analogy condition, consistent with most of the cognitive processing of the analogy condition having occurred in the prior task phases. Overall we demonstrate that the left ventral and dorsal lateral, medial, and rostral PFC are important in both the encoding of relational information, mapping and inference processes, and verification of semantic and perceptual responses in four term analogical reasoning. Copyright 2010 Elsevier B.V. All rights reserved.

Mixed signal custom integrated circuit development for physics instrumentation

International Nuclear Information System (INIS)

Britton, C.L. Jr.; Bryan, W.L.; Emery, M.S.

1998-01-01

The Monolithic Systems Development Group at the Oak Ridge National Laboratory has been greatly involved in custom mixed-mode integrated circuit development for the PHENIX detector at the Relativistic Heavy Ion collider (RHIC) at Brookhaven National Laboratory and position-sensitive germanium spectrometer front-ends for the Naval Research Laboratory (NRL). This paper will outline the work done for both PHENIX and the Naval Research Laboratory in the area of full-custom, mixed-signal CMOS integrated electronics. This paper presents the architectures chosen for the various PHENIX detectors which include position-sensitive silicon, capacitive pixel, and phototube detectors, and performance results for the subsystems as well as a system description of the NRL germanium strip system and its performance. The performance of the custom preamplifiers, discriminators, analog memories, analog-digital converters, and control circuitry for all systems will be presented

Mixed signal custom integrated circuit development for physics instrumentation

Energy Technology Data Exchange (ETDEWEB)

Britton, C.L. Jr.; Bryan, W.L.; Emery, M.S. [and others

1998-10-01

The Monolithic Systems Development Group at the Oak Ridge National Laboratory has been greatly involved in custom mixed-mode integrated circuit development for the PHENIX detector at the Relativistic Heavy Ion collider (RHIC) at Brookhaven National Laboratory and position-sensitive germanium spectrometer front-ends for the Naval Research Laboratory (NRL). This paper will outline the work done for both PHENIX and the Naval Research Laboratory in the area of full-custom, mixed-signal CMOS integrated electronics. This paper presents the architectures chosen for the various PHENIX detectors which include position-sensitive silicon, capacitive pixel, and phototube detectors, and performance results for the subsystems as well as a system description of the NRL germanium strip system and its performance. The performance of the custom preamplifiers, discriminators, analog memories, analog-digital converters, and control circuitry for all systems will be presented.

Analog and digital dividers for mass spectrometers

International Nuclear Information System (INIS)

Osipov, A.K.

1980-01-01

Errors of four different types of stress dividers used in statical mass-spectrometers for determination of mass number by accelerating stress are analyzed. The simplest flowsheet of the analog divider comprises operation amplifier, in the chain of the negative feedback of which a multiplication device on differential cascade is switched- in. This analog divider has high sensitivity to temperature and high error approximately 5%. Application of the multiplier on differential cascade with normalization permits to increase temperature stability and decrease the error up to 1%. Another type of the analog divider is a logarithmic divider the error of which is constant within the whole operation range and it constitutes 1-5%. The digital divider with a digital-analog transformer (DAT) has the error of +-0.015% which is determined by the error of detectors and resistance of keys in the locked state. Considered is the design of a divider based on transformation of the inlet stress into the time period. The error of the divider is determined in this case mainly by stress of the zero shift of the operation amplifier (it should be compensated) and relative threshold stability of the comparator triggering which equals (2-3)x10 -4 . It is noted that the divider with DAT application and the divider with the use of stress transformation within the time period are most perspective ones for statical mass-spectrometers [ru

The neural substrate of analogical reasoning: an fMRI study.

Science.gov (United States)

Luo, Qian; Perry, Conrad; Peng, Danling; Jin, Zhen; Xu, Duo; Ding, Guosheng; Xu, Shiyong

2003-10-01

This study investigated the anatomical substrate of analogical reasoning using functional magnetic resonance imaging. In the study, subjects performed a verbal analogy task (e.g., soldier is to army as drummer is to band) and, to control for activation caused by purely semantic access, a semantic judgment task. Significant activation differences between the verbal analogy and the semantic judgment task were found bilaterally in the prefrontal cortex (right BA 11/BA 47 and left BA45), the fusiform gyrus, and the basal ganglia; left lateralized in the postero-superior temporal gyrus (BA 22) and the (para) hippocampal region; and right lateralized in the anterior cingulate. The role of these areas in analogical reasoning is discussed.

SEAS: A simulated evolution approach for analog circuit synthesis

NARCIS (Netherlands)

Ning, Zhen-Qiu; Ning, Zhen-Qiu; Mouthaan, A.J.; Wallinga, Hans

1991-01-01

The authors present a simulated evolution approach for analog circuit synthesis based on an analogy with the natural selection process in biological environments and on the iterative improvements in solving engineering problems. A prototype framework based on this idea, called SEAS, has been

Generalized Tensor Analysis Model for Multi-Subcarrier Analog Optical Systems

DEFF Research Database (Denmark)

Zhao, Ying; Yu, Xianbin; Zheng, Xiaoping

2011-01-01

We propose and develop a general tensor analysis framework for a subcarrier multiplex analog optical fiber link for applications in microwave photonics. The goal of this work is to construct an uniform method to address nonlinear distortions of a discrete frequency transmission system. We employ....... In addition, it is demonstrated that each corresponding tensor is formally determined by device structures, which allows for a synthesized study of device combinations more systematically. For implementing numerical methods, the practical significance of the tensor model is it simplifies the derivation...... details compared with series-based approaches by hiding the underlying multi-fold summation and index operation. The integrity of the proposed methodology is validated by investigating the classical intensity modulated system. Furthermore, to give an application model of the tensor formalism, we make...

21 CFR 582.5477 - Methionine hydroxy analog and its calcium salts.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Methionine hydroxy analog and its calcium salts... Nutrients and/or Dietary Supplements 1 § 582.5477 Methionine hydroxy analog and its calcium salts. (a) Product. Methionine hydroxy analog and its calcium salts. (b) [Reserved] (c) Limitations, restrictions, or...

Chimpanzee (Pan troglodytes) relational matching: playing by their own (analogical) rules.

Science.gov (United States)

Flemming, Timothy M; Kennedy, Erica Hoy

2011-05-01

Chimpanzees (Pan troglodytes) have been known to exhibit rudimentary abilities in analogical reasoning (Flemming, Beran, Thompson, Kleider, & Washburn, 2008; Gillian, Premack, & Woodruff, 1981; Haun & Call, 2009; Thompson & Oden, 2000; Thompson, Oden, & Boysen, 1997). With a wide array of individual differences, little can be concluded about the species' capacity for analogies, much less their strategies employed for solving such problems. In this study, we examined analogical strategies in 3 chimpanzees using a 3-dimensional search task (e.g., Kennedy & Fragaszy, 2008). Food items were hidden under 1 of 2 or 3 plastic cups of varying sizes. Subsequently, chimpanzees searched for food under the cup of the same relative size in their own set of cups--reasoning by analogy. Two chimpanzees initially appeared to fail the first relational phase of the task. Meta-analyses revealed, however, that they were instead using a secondary strategy not rewarded by the contingencies of the task--choosing on the basis of the same relative position in the sample. Although this was not the intended strategy of the task, it was nonetheless analogical. In subsequent phases of the task, chimpanzees eventually learned to shift their analogical reasoning strategy to match the reward contingencies of the task and successfully choose on the basis of relative size. This evidence not only provides support for the analogical ape hypothesis (Thompson & Oden, 2000), but also exemplifies how foundational conceptually mediated analogical behavior may be for the chimpanzee. 2011 APA, all rights reserved

A CMOS Integrating Amplifier for the PHENIX Ring Imaging Cherenkov detector

International Nuclear Information System (INIS)

Wintenberg, A.L.; Jones, J.P. Jr.; Young, G.R.; Moscone, C.G.

1997-11-01

A CMOS integrating amplifier has been developed for use in the PHENIX Ring Imaging Cherenkov (RICH) detector. The amplifier, consisting of a charge-integrating amplifier followed by a variable gain amplifier (VGA), is an element of a photon measurement system comprising a photomultiplier tube, a wideband, gain of 10 amplifier, the integrating amplifier, and an analog memory followed by an ADC and double correlated sampling implemented in software. The integrating amplifier is designed for a nominal full scale input of 160 pC with a gain of 20 mV/pC and a dynamic range of 1000:1. The VGA is used for equalizing gains prior to forming analog sums for trigger purposes. The gain of the VGA is variable over a 3:1 range using a 5 bits digital control, and the risetime is held to approximately 20 ns using switched compensation in the VGA. Details of the design and results from several prototype devices fabricated in 1.2 microm Orbit CMOS are presented. A complete noise analysis of the integrating amplifier and the correlated sampling process is included as well as a comparison of calculated, simulated and measured results

A CMOS Integrating Amplifier for the PHENIX Ring Imaging Cherenkov detector

Energy Technology Data Exchange (ETDEWEB)

Wintenberg, A.L.; Jones, J.P. Jr.; Young, G.R. [Oak Ridge National Lab., TN (United States); Moscone, C.G. [Tennessee Univ., Knoxville, TN (United States)

1997-11-01

A CMOS integrating amplifier has been developed for use in the PHENIX Ring Imaging Cherenkov (RICH) detector. The amplifier, consisting of a charge-integrating amplifier followed by a variable gain amplifier (VGA), is an element of a photon measurement system comprising a photomultiplier tube, a wideband, gain of 10 amplifier, the integrating amplifier, and an analog memory followed by an ADC and double correlated sampling implemented in software. The integrating amplifier is designed for a nominal full scale input of 160 pC with a gain of 20 mV/pC and a dynamic range of 1000:1. The VGA is used for equalizing gains prior to forming analog sums for trigger purposes. The gain of the VGA is variable over a 3:1 range using a 5 bits digital control, and the risetime is held to approximately 20 ns using switched compensation in the VGA. Details of the design and results from several prototype devices fabricated in 1.2 {micro}m Orbit CMOS are presented. A complete noise analysis of the integrating amplifier and the correlated sampling process is included as well as a comparison of calculated, simulated and measured results.

22nd Workshop on Advances in Analog Circuit Design

CERN Document Server

Makinwa, Kofi; Harpe, Pieter

2014-01-01

This book is based on the 18 tutorials presented during the 22nd workshop on Advances in Analog Circuit Design.  Expert designers present readers with information about a variety of topics at the frontier of analog circuit design, including frequency reference, power management for systems-on-chip, and smart wireless interfaces.  This book serves as a valuable reference to the state-of-the-art, for anyone involved in analog circuit research and development.    ·         Provides a state-of-the-art reference in analog circuit design, written by experts from industry and academia; ·         Presents material in a tutorial-based format; ·         Includes coverage of frequency reference, power management for systems-on-chip, and smart wireless interfaces.

Analogy in systems management: a theoretical inquiry

Energy Technology Data Exchange (ETDEWEB)

Silverman, B.G.

1983-11-01

This theoretical analysis of the intuitive and diffuse characteristics of analogical reasoning processes is the first step in a research effort intended to lead to: understanding of common (and possibly costly) errors, pitfalls, travails, and problem-solving impediments; possible recommendations for improvements to organizational structures, control and coordination processes, and management information flows, and guidelines for a generalized analogical reasoning support framework (e.g., a handbook, a knowledge bank design, and/or even a software package/artificial intelligence program). 233 references.

Analogical reasoning abilities of recovering alcoholics.

Science.gov (United States)

Gardner, M K; Clark, E; Bowman, M A; Miller, P J

1989-08-01

This study investigated analogical reasoning abilities of alcoholics who had been abstinent from alcohol for at least 1 year. Their performance was compared to that of nonalcoholic controls matched as a group for education, age, and gender. Solution times and error rates were modeled using a regression model. Results showed a nonsignificant trend for alcoholics to be faster, but more error prone, than controls. The same componential model applied to both groups, and fit them equally well. Although differences have been found in analogical reasoning ability between controls and alcoholics immediately following detoxification, we find no evidence of differences after extended periods of sobriety.

Terrestrial Analogs to Mars: NRC Community Panel Decadal Report

Science.gov (United States)

Farr, T. G.

2002-12-01

A report was completed recently by a Community Panel for the NRC Decadal Study of Solar System Exploration. The desire was for a review of the current state of knowledge and for recommendations for action over the next decade. The topic of this panel, Terrestrial Analogs to Mars, was chosen to bring attention to the need for an increase in analog studies in support of the increased pace of Mars exploration. It is well recognized that interpretations of Mars must begin with the Earth as a reference. The most successful comparisons have focused on understanding geologic processes on the Earth well enough to extrapolate to Mars' environment. Several facets of terrestrial analog studies have been pursued and are continuing. These studies include field workshops, characterization of terrestrial analog sites, instrument tests, laboratory measurements (including analysis of martian meteorites), and computer and laboratory modeling. The combination of all of these activities allows scientists to constrain the processes operating in specific terrestrial environments and extrapolate how similar processes could affect Mars. The Terrestrial Analogs for Mars Community Panel has considered the following two key questions: (1) How do terrestrial analog studies tie in to the overarching science questions about life, past climate, and geologic evolution of Mars, and (2) How can future instrumentation be used to address these questions. The panel considered the issues of data collection and archiving, value of field workshops, laboratory measurements and modeling, human exploration issues, association with other areas of solar system exploration, and education and public outreach activities. Parts of this work were performed under contract to NASA.

How do Analogizing and Mental Simulation Influence Team Dynamics in Innovative Product Design?

DEFF Research Database (Denmark)

Casakin, Hernan; Ball, Linden J.; Christensen, Bo T.

2015-01-01

association with team cohesion, whereas solution generation and function finding had a stronger association with team collaboration. We propose that analogizing and mental simulations are strategies that serve valuable functions in engendering enhanced cohesion and collaboration, which might be expected...... and team collaboration. Analogies were coded for “analogical distance” (i.e., within domain or between domain) and “analogical purpose” (i.e., problem identification, function finding, solution generation, and explanation). The results indicated that the presence of either analogizing or mental simulation...... was related to team cohesion and team collaboration, with mental simulation having an especially marked association with team collaboration. Within-domain analogizing was found to enhance team collaboration, but it did not influence team cohesion. Furthermore, all types of analogical purpose showed a similar...

PENALARAN ANALOGI SISWA DALAM MENYELESAIKAN MASALAH LUAS DAN KELILING SEGITIGA DAN SEGIEMPAT

Directory of Open Access Journals (Sweden)

Dyah Ayu Pramoda Wardhani

2016-09-01

Penalaran analogi adalah proses penarikan kesimpulan dengan menggunakan kesamaan sifat dan struktur hubungan dari permasalahan sumber untuk diaplikasikan pada permasalahan target. Penelitian ini bertujuan untuk mendeskripsikan penalaran analogi siswa kelas VIII dalam menyelesaikan masalah luas dan keliling segitiga dan segiempat. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan kualitatif dengan jenis penelitian deskriptif. Hasil penelitian ini menunjukkan penalaran analogi siswa kemampuan tinggi terjadi dengan baik. Penalaran analogi siswa kelompok sedang cenderung terjadi cukup baik. Ada beberapa hambatan yang dialami siswa kelompok sedang, yaitu pada proses mapping. Penalaran analogi siswa kemampuan rendah menunjukkan bahwa subjek tidak dapat memahami masalah yang diberikan.

Precision analog signal processor for beam position measurements in electron storage rings

International Nuclear Information System (INIS)

Hinkson, J.A.; Unser, K.B.

1995-05-01

Beam position monitors (BPM) in electron and positron storage rings have evolved from simple systems composed of beam pickups, coaxial cables, multiplexing relays, and a single receiver (usually a analyzer) into very complex and costly systems of multiple receivers and processors. The older may have taken minutes to measure the circulating beam closed orbit. Today instrumentation designers are required to provide high-speed measurements of the beam orbit, often at the ring revolution frequency. In addition the instruments must have very high accuracy and resolution. A BPM has been developed for the Advanced Light Source (ALS) in Berkeley which features high resolution and relatively low cost. The instrument has a single purpose; to measure position of a stable stored beam. Because the pickup signals are multiplexed into a single receiver, and due to its narrow bandwidth, the receiver is not intended for single-turn studies. The receiver delivers normalized measurements of X and Y position entirely by analog means at nominally 1 V/mm. No computers are involved. No software is required. Bergoz, a French company specializing in precision beam instrumentation, integrated the ALS design m their new BPM analog signal processor module. Performance comparisons were made on the ALS. In this paper we report on the architecture and performance of the ALS prototype BPM

Further evaluation of the tropane analogs of haloperidol.

Science.gov (United States)

Sampson, Dinithia; Bricker, Barbara; Zhu, Xue Y; Peprah, Kwakye; Lamango, Nazarius S; Setola, Vincent; Roth, Bryan L; Ablordeppey, Seth Y

2014-09-01

Previous work from our labs has indicated that a tropane analog of haloperidol with potent D2 binding but designed to avoid the formation of MPP(+)-like metabolites, such as 4-(4-chlorophenyl)-1-(4-(4-fluorophenyl)-4-oxobutyl)pyridin-1-ium (BCPP(+)) still produced catalepsy, suggesting a strong role for the D2 receptor in the production of catalepsy in rats, and hence EPS in humans. This study tested the hypothesis that further modifications of the tropane analog to produce compounds with less potent binding to the D2 receptor than haloperidol, would produce less catalepsy. These tests have now revealed that while haloperidol produced maximum catalepsy, these compounds produced moderate to low levels of catalepsy. Compound 9, with the least binding affinity to the D2R, produced the least catalepsy and highest Minimum Adverse Effective Dose (MAED) of the analogs tested regardless of their affinities at other receptors including the 5-HT1AR. These observations support the hypothesis that moderation of the D2 binding of the tropane analogs could reduce catalepsy potential in rats and consequently EPS in man. Published by Elsevier Ltd.

Varieties of noise: analogical reasoning in synthetic biology.

Science.gov (United States)

Knuuttila, Tarja; Loettgers, Andrea

2014-12-01

The picture of synthetic biology as a kind of engineering science has largely created the public understanding of this novel field, covering both its promises and risks. In this paper, we will argue that the actual situation is more nuanced and complex. Synthetic biology is a highly interdisciplinary field of research located at the interface of physics, chemistry, biology, and computational science. All of these fields provide concepts, metaphors, mathematical tools, and models, which are typically utilized by synthetic biologists by drawing analogies between the different fields of inquiry. We will study analogical reasoning in synthetic biology through the emergence of the functional meaning of noise, which marks an important shift in how engineering concepts are employed in this field. The notion of noise serves also to highlight the differences between the two branches of synthetic biology: the basic science-oriented branch and the engineering-oriented branch, which differ from each other in the way they draw analogies to various other fields of study. Moreover, we show that fixing the mapping between a source domain and the target domain seems not to be the goal of analogical reasoning in actual scientific practice.

Metabolomic Discovery of Novel Urinary Galabiosylceramide Analogs as Fabry Disease Biomarkers

Science.gov (United States)

Boutin, Michel; Auray-Blais, Christiane

2015-03-01

Fabry disease is an X-linked, complex, multisystemic lysosomal storage disorder presenting marked phenotypic and genotypic variability among affected male and female patients. Glycosphingolipids, mainly globotriaosylceramide (Gb3) isoforms/analogs, globotriaosylsphingosine (lyso-Gb3) and analogs, as well as galabiosylceramide (Ga2) isoforms/analogs accumulate in the vascular endothelium, nerves, cardiomyocytes, renal glomerular and tubular epithelial cells, and biological fluids. The search for biomarkers reflecting disease severity and progression is still on-going. A metabolomic study using quadrupole time-of-flight mass spectrometry has revealed 22 galabiosylceramide isoforms/analogs in urine of untreated Fabry patients classified in seven groups according to their chemical structure: (1) Saturated fatty acid; (2) one extra double bond; (3) two extra double bonds; (4) hydroxylated saturated fatty acid; (5) hydroxylated fatty acid and one extra double bond; (6) hydrated sphingosine and hydroxylated fatty acid; (7) methylated amide linkage. Relative quantification of both Ga2 and Gb3 isoforms/analogs was performed. All these biomarkers are significantly more abundant in urine samples from untreated Fabry males compared with healthy male controls. A significant amount of Ga2 isoforms/analogs, accounting for 18% of all glycosphingolipids analyzed (Ga2 + Gb3 and respective isoforms/analogs), were present in urine of Fabry patients. Gb3 isoforms containing saturated fatty acids are the most abundant (60.9%) compared with 26.3% for Ga2. A comparison between Ga2 isoforms/analogs and their Gb3 counterparts also showed that the proportion of analogs with hydroxylated fatty acids is significantly greater for Ga2 (35.8%) compared with Gb3 (1.9%). These results suggest different biological pathways involved in the synthesis and/or degradation of Gb3 and Ga2 metabolites.

Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells

Directory of Open Access Journals (Sweden)

Madácsi Ramóna

2010-06-01

Full Text Available Abstract Background Cytoplasmic lipid-droplets are common inclusions of eukaryotic cells. Lipid-droplet binding thalidomide analogs (2,6-dialkylphenyl-4/5-amino-substituted-5,6,7-trifluorophthalimides with potent anticancer activities were synthesized. Results Cytotoxicity was detected in different cell lines including melanoma, leukemia, hepatocellular carcinoma, glioblastoma at micromolar concentrations. The synthesized analogs are non-toxic to adult animals up to 1 g/kg but are teratogenic to zebrafish embryos at micromolar concentrations with defects in the developing muscle. Treatment of tumor cells resulted in calcium release from the endoplasmic reticulum (ER, induction of reactive oxygen species (ROS, ER stress and cell death. Antioxidants could partially, while an intracellular calcium chelator almost completely diminish ROS production. Exogenous docosahexaenoic acid or eicosapentaenoic acid induced calcium release and ROS generation, and synergized with the analogs in vitro, while oleic acid had no such an effect. Gene expression analysis confirmed the induction of ER stress-mediated apoptosis pathway components, such as GADD153, ATF3, Luman/CREB3 and the ER-associated degradation-related HERPUD1 genes. Tumor suppressors, P53, LATS2 and ING3 were also up-regulated in various cell lines after drug treatment. Amino-phthalimides down-regulated the expression of CCL2, which is implicated in tumor metastasis and angiogenesis. Conclusions Because of the anticancer, anti-angiogenic action and the wide range of applicability of the immunomodulatory drugs, including thalidomide analogs, lipid droplet-binding members of this family could represent a new class of agents by affecting ER-membrane integrity and perturbations of ER homeostasis.

Real time event selection and flash analog-to-digital converters

International Nuclear Information System (INIS)

Imori, Masatosi

1983-01-01

In high-energy particle experiments, high-speed analog logic is employed to select events on a real-time basis. Flash analog-to-digital converters replace the high-speed analog logic with digital logic. The digital logic gives great flexibility to the scheme for real-time event selection. This paper proposes the use of flash A/D converters for the logic used to obtain the total sum of the energy deposited in individual counters in a shower detector. (author)

Analog circuit design a tutorial guide to applications and solutions

CERN Document Server

Williams, Jim

2011-01-01

* Covers the fundamentals of linear/analog circuit and system design to guide engineers with their design challenges. * Based on the Application Notes of Linear Technology, the foremost designer of high performance analog products, readers will gain practical insights into design techniques and practice. * Broad range of topics, including power management tutorials, switching regulator design, linear regulator design, data conversion, signal conditioning, and high frequency/RF design. * Contributors include the leading lights in analog design, Robert Dobkin, Jim Willia

Programs for control of an analog-signal switching network

International Nuclear Information System (INIS)

D'Ottavio, T.; Enriquez, R.; Katz, R.; Skelly, J.

1989-01-01

A suite of programs has been developed to control the network of analog-signal switching multiplexers in the AGS complex. The software is driven by a relational database which describes the architecture of the multiplexer tree and the set of available analog signals. Signals are routed through a three-layer multiplexer tree, to be made available at four consoles each with three 4-trace oscilloscopes. A menu-structured operator interface program is available at each console, to accept requests to route any available analog signal to any of that console's 12 oscilloscope traces. A common routing-server program provides automatic routing-server program provides automatic routing of requested signals through the layers of multiplexers, maintaining a reservation database to denote free and in-use trunks. Expansion of the analog signal system is easily accommodated in software by adding new signals, trunks, multiplexers, or consoles to the database. Programmatic control of the triggering signals for each of the oscilloscopes is also provided. 3 refs., 4 figs., 3 tabs

Concept Confusion and Concept Discernment in Basic Magnetism Using Analogical Reasoning

Science.gov (United States)

Lemmer, Miriam; Morabe, Olebogeng Nicodimus

2017-01-01

Analogical reasoning is central to all learning, whether in daily life situations, in the classroom or while doing research. Although analogies can aid the learning process of making sense of phenomena and understanding new ideas in terms of known ideas, these should be used with care. This article reports a study of the use of analogies and the…

Connecting long distance: semantic distance in analogical reasoning modulates frontopolar cortex activity.

Science.gov (United States)

Green, Adam E; Kraemer, David J M; Fugelsang, Jonathan A; Gray, Jeremy R; Dunbar, Kevin N

2010-01-01

Solving problems often requires seeing new connections between concepts or events that seemed unrelated at first. Innovative solutions of this kind depend on analogical reasoning, a relational reasoning process that involves mapping similarities between concepts. Brain-based evidence has implicated the frontal pole of the brain as important for analogical mapping. Separately, cognitive research has identified semantic distance as a key characteristic of the kind of analogical mapping that can support innovation (i.e., identifying similarities across greater semantic distance reveals connections that support more innovative solutions and models). However, the neural substrates of semantically distant analogical mapping are not well understood. Here, we used functional magnetic resonance imaging (fMRI) to measure brain activity during an analogical reasoning task, in which we parametrically varied the semantic distance between the items in the analogies. Semantic distance was derived quantitatively from latent semantic analysis. Across 23 participants, activity in an a priori region of interest (ROI) in left frontopolar cortex covaried parametrically with increasing semantic distance, even after removing effects of task difficulty. This ROI was centered on a functional peak that we previously associated with analogical mapping. To our knowledge, these data represent a first empirical characterization of how the brain mediates semantically distant analogical mapping.

Modeling selective attention using a neuromorphic analog VLSI device.

Science.gov (United States)

Indiveri, G

2000-12-01

Attentional mechanisms are required to overcome the problem of flooding a limited processing capacity system with information. They are present in biological sensory systems and can be a useful engineering tool for artificial visual systems. In this article we present a hardware model of a selective attention mechanism implemented on a very large-scale integration (VLSI) chip, using analog neuromorphic circuits. The chip exploits a spike-based representation to receive, process, and transmit signals. It can be used as a transceiver module for building multichip neuromorphic vision systems. We describe the circuits that carry out the main processing stages of the selective attention mechanism and provide experimental data for each circuit. We demonstrate the expected behavior of the model at the system level by stimulating the chip with both artificially generated control signals and signals obtained from a saliency map, computed from an image containing several salient features.

Barrier analogs: Long-term performance issues, preliminary studies, and recommendations

Energy Technology Data Exchange (ETDEWEB)

Waugh, W.J. [Rust Geotech, Inc., Grand Junction, CO (United States). Environmental Sciences Lab.; Chatters, J.C.; Last, G.V.; Bjornstad, B.N.; Link, S.O. [Pacific Northwest Lab., Richland, WA (United States); Hunter, C.R. [Cascade Earth Sciences, La Grande, OR (United States)

1994-02-01

The US Department of Energy`s Hanford Protective Barrier Development Program is funding studies of natural analogs of the long-term performance of waste site covers. Natural-analog studies examine past environments as evidence for projecting the future performance of engineered structures. The information generated by analog studies is needed to (1) evaluate the designs and results of short term experiments and demonstrations, (2) formulate performance-modeling problems that bound expected changes in waste site environments, and (3) understand emergent system attributes that cannot be evaluated with short-term experiments or computer models. Waste site covers will be part of dynamic environmental systems with attributes that transcend the traits of engineered components. This report discusses results of the previously unreported preliminary studies conducted in 1983 and 1984. These results indicate that analogs could play an important role in predicting the long-term behavior of engineered waste covers. Layered exposures of glacial-flood-deposited gravels mantled with silt or sand that resemble contemporary barrier designs were examined. Bergmounds, another anomaly left by cataclysmic glacial floods, were also examined as analogs of surface gravel.

Effect of curcumin analogs onα-synuclein aggregation and cytotoxicity

Science.gov (United States)

Jha, Narendra Nath; Ghosh, Dhiman; Das, Subhadeep; Anoop, Arunagiri; Jacob, Reeba S.; Singh, Pradeep K.; Ayyagari, Narasimham; Namboothiri, Irishi N. N.; Maji, Samir K.

2016-01-01

Alpha-synuclein (α-Syn) aggregation into oligomers and fibrils is associated with dopaminergic neuron loss occurring in Parkinson’s disease (PD) pathogenesis. Compounds that modulate α-Syn aggregation and interact with preformed fibrils/oligomers and convert them to less toxic species could have promising applications in the drug development efforts against PD. Curcumin is one of the Asian food ingredient which showed promising role as therapeutic agent against many neurological disorders including PD. However, the instability and low solubility makes it less attractive for the drug development. In this work, we selected various curcumin analogs and studied their toxicity, stability and efficacy to interact with different α-Syn species and modulation of their toxicity. We found a subset of curcumin analogs with higher stability and showed that curcumin and its various analogs interact with preformed fibrils and oligomers and accelerate α-Syn aggregation to produce morphologically different amyloid fibrils in vitro. Furthermore, these curcumin analogs showed differential binding with the preformed α-Syn aggregates. The present data suggest the potential role of curcumin analogs in modulating α-Syn aggregation. PMID:27338805

Using Analogies in Teaching Physics: A Study on Latvian Teachers' Views and Experience

Science.gov (United States)

Jonane, Lolita

2015-01-01

The role of analogies as tools for teaching difficult science concepts has been widely discussed in science education. The application of analogies in the context of sustainable education involves richer potential. The purposeful use of appropriate analogies can facilitate analogical thinking and transfer skills, as well as develop abilities which…

47 CFR 74.705 - TV broadcast analog station protection.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 4 2010-10-01 2010-10-01 false TV broadcast analog station protection. 74.705... EXPERIMENTAL RADIO, AUXILIARY, SPECIAL BROADCAST AND OTHER PROGRAM DISTRIBUTIONAL SERVICES Low Power TV, TV Translator, and TV Booster Stations § 74.705 TV broadcast analog station protection. (a) The TV broadcast...

Verbal Analogical Reasoning in Children with Language-Learning Disabilities.

Science.gov (United States)

Masterson, Julie J.; And Others

1993-01-01

Children (ages 9-13) with language-learning disabilities were administered 5 types of verbal analogies: synonyms, antonyms, linear order, category membership, and functional relationship. Subjects performed worse than mental age-matched children on all types of analogies and performed worse than language age-matched children on all types except…

Analog capacitance ROM with IGFET bucket-brigade shift register

DEFF Research Database (Denmark)

Bruun, Erik; Olesen, Ole

1975-01-01

A new type of monolithic analog read-out memory is described. It consists of a memory element and associated on-chip readout circuitry. The memory can be used for storing sample values of time-varying analog signals. The memory element is a matrix of MOS capacitors, preprogrammed in size...

Electrochemical deposition of magnesium from analogous ionic liquid based on dimethylformamide

International Nuclear Information System (INIS)

Wang, Huaiyou; Jia, Yongzhong; Wang, Xiaohua; Yao, Ying; Yue, Duyuan; Jing, Yan

2013-01-01

In this paper, a homogeneous, colorless analogous ionic liquid containing dimethylformamide (DMF) and magnesium chloride hexahydrate is synthesized. The conductivity of analogous ionic liquid is measured as a function of temperature and composition. Irreversible electrochemical behavior was generally observed by cyclic voltammetry (CV) in the analogous ionic liquid based electrolytes containing simple Mg salt. CV also shows that the reducing reaction of Mg 2+ is a diffusion control process. Electrochemical impedance spectroscopy (EIS) of analogous ionic liquid was measured at 20 °C, 40 °C and 60 °C. Electrodeposition of magnesium metal from analogous ionic liquid has been studied. The Mg deposits are also systematically characterized by the techniques of powder X-ray diffraction (XRD), scanning electron microscope (SEM) and energy dispersive spectroscopy (EDS). Results showed that magnesium was found in the deposited film

Analog Integrated Circuit Design for Spike Time Dependent Encoder and Reservoir in Reservoir Computing Processors

Science.gov (United States)

2018-01-01

HAS BEEN REVIEWED AND IS APPROVED FOR PUBLICATION IN ACCORDANCE WITH ASSIGNED DISTRIBUTION STATEMENT. FOR THE CHIEF ENGINEER : / S / / S...bridged high-performance computing, nanotechnology , and integrated circuits & systems. 15. SUBJECT TERMS neuromorphic computing, neuron design, spike...multidisciplinary effort encompassed high-performance computing, nanotechnology , integrated circuits, and integrated systems. The project’s architecture was

UV IRRADIATION OF AROMATIC NITROGEN HETEROCYCLES IN INTERSTELLAR ICE ANALOGS

Science.gov (United States)

Elsila, J. E.; Bernstein, M. P.; Sanford, S. A.

2005-01-01

Here, we present information on the properties of the ANH quinoline frozen in interstellar water-ice analogs. Quinoline is a two-ring compound structurally analogous to the PAH naphthalene. In this work, binary mixtures of water and quinoline were frozen to create interstellar ice analogs, which were then subjected to ultraviolet photolysis. We will present the infrared spectra of the resulting ices at various temperatures, as well as chromatographic analysis of the residues remaining upon warm-up of these ices to room temperature.

The analogic model ''RIC'' of thermal behaviour of mass concrete

International Nuclear Information System (INIS)

Gonzalez Redondo, M.; Gonzalez de Posada, F.; Plana Claver, J.

1997-01-01

In order to study the thermal field and calorific flows in heat sources (i.e. mass concrete during setting) we have conceived, built and experimented with an analogical electric model. This model, named RIC, consists of resistors (R) and capacitors (C) in which nodes an electric current (I) has been injected. Several analogical constants were used for the mathematical approximation. Thus, this paper describes the analogical RIC model, simulating heat generation, boundary and initial conditions and concreting. (Author) 4 refs

Analog data transmission via fiber optics

International Nuclear Information System (INIS)

Cisneros, E.L.; Burgueno, G.F.

1987-01-01

In the SLAC Linear Collider Detector (SLD), as in most high-energy particle detectors, the electromagnetic noise environment is the limiting factor in electronic readout performance. Front-end electronics are particularly susceptible to electromagnetic interference (EMI), and great care has been taken to minimize its effects. The transfer of preprocessed analog signals from the detector environs, to the remote digital processing electronics, by conventional means (via metal conductors), may ultimately limit the performance of the system. Because it is highly impervious to EMI and ground loops, a fiber-optic medium has been chosen for the transmission of these signals. This paper describes several fiber-optic transmission schemes which satisfy the requirements of the SLD analog data transmission

Analog data transmission via fiber optics

International Nuclear Information System (INIS)

Cisneros, E.L.; Burgueno, G.F.

1986-10-01

In the SLAC Linear Collider Detector (SLD), as in most high-energy particle detectors, the electromagnetic noise environment is the limiting factor in electronic readout performance. Front-end electronics are particulary susceptible to electromagnetic interference (EMI), and great care has been taken to minimize its effects. The transfer of preprocessed analog signals from the detector environs, to the remote digital processing electronics, by conventional means (via metal conductors), may ultimately limit the performance of the system. Because it is highly impervious to EMI and ground loops, a fiber-optic medium has been chosen for the transmission of these signals. This paper describes several fiber-optic transmission schemes which satisfy the requirements of the SLD analog data transmission

An analogy strategy for transformation optics

International Nuclear Information System (INIS)

Yao, Kan; Liu, Yongmin; Chen, Huanyang; Jiang, Xunya

2014-01-01

We introduce an analogy strategy to design transformation optical devices. Based on the similarities between field lines in different physical systems, the trajectories of light can be intuitively determined to curve in a gentle manner, and the resulting materials are isotropic and nonmagnetic. Furthermore, the physical meaning of the analogue problems plays a key role in the removal of dielectric singularities. We illustrate this approach by creating two designs of carpet cloak and a collimating lens as representative examples in two- and three-dimensional spaces, respectively. The analogy strategy not only reveals the intimate connections between different physical disciplines, such as optics, fluid mechanics and electrostatics, but also provides a heuristic pathway to designing advanced photonic systems

The optical analogy for vector fields

Science.gov (United States)

Parker, E. N. (Editor)

1991-01-01

This paper develops the optical analogy for a general vector field. The optical analogy allows the examination of certain aspects of a vector field that are not otherwise readily accessible. In particular, in the cases of a stationary Eulerian flow v of an ideal fluid and a magnetostatic field B, the vectors v and B have surface loci in common with their curls. The intrinsic discontinuities around local maxima in absolute values of v and B take the form of vortex sheets and current sheets, respectively, the former playing a fundamental role in the development of hydrodyamic turbulence and the latter playing a major role in heating the X-ray coronas of stars and galaxies.

On automatic synthesis of analog/digital circuits

Energy Technology Data Exchange (ETDEWEB)

Beiu, V.

1998-12-31

The paper builds on a recent explicit numerical algorithm for Kolmogorov`s superpositions, and will show that in order to synthesize minimum size (i.e., size-optimal) circuits for implementing any Boolean function, the nonlinear activation function of the gates has to be the identity function. Because classical and--or implementations, as well as threshold gate implementations require exponential size, it follows that size-optimal solutions for implementing arbitrary Boolean functions can be obtained using analog (or mixed analog/digital) circuits. Conclusions and several comments are ending the paper.

Kinematics and age of 15 stars-photometric solar analogs

Science.gov (United States)

Galeev, A. I.; Shimansky, V. V.

2008-03-01

The radial and space velocities are inferred for 15 stars that are photometric analogs of the Sun. The space velocity components (U, V, W) of most of these stars lie within the 10-60 km/s interval. The star HD 225239, which in our previous papers we classified as a subgiant, has a space velocity exceeding 100 km/s, and belongs to the thick disk. The inferred fundamental parameters of the atmospheres of solar analogs are combined with published evolutionary tracks to estimate the masses and ages of the stars studied. The kinematics of photometric analogs is compared to the data for a large group of solar-type stars.

Analogical Reasoning in the Classroom: Insights from Cognitive Science

Science.gov (United States)

Vendetti, Michael S.; Matlen, Bryan J.; Richland, Lindsey E.; Bunge, Silvia A.

2015-01-01

Applying knowledge from one context to another is a notoriously difficult problem, both for children and adults, but lies at the heart of educational endeavors. Analogical reasoning is a cognitive underpinning of the ability to notice and draw similarities across contexts. Reasoning by analogy is especially challenging for students, who must…

Young Children's Analogical Reasoning across Cultures: Similarities and Differences

Science.gov (United States)

Richland, Lindsey Engle; Chan, Tsz-Kit; Morrison, Robert G.; Au, Terry Kit-Fong

2010-01-01

A cross-cultural comparison between U.S. and Hong Kong preschoolers examined factors responsible for young children's analogical reasoning errors. On a scene analogy task, both groups had adequate prerequisite knowledge of the key relations, were the same age, and showed similar baseline performance, yet Chinese children outperformed U.S. children…

Fluorinated Analogs of Malachite Green: Synthesis and Toxicity

Directory of Open Access Journals (Sweden)

Bahram Parvin

2008-04-01

Full Text Available A series of fluorinated analogs of malachite green (MG have been synthesizedand their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell lineexamined. The toxicity profiles were found to be different for these two species. Twoanalogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem tobe the most promising analogs because they showed the lowest toxicity to the human cells.

Analog Organic Electronics Building Blocks for Organic Smart Sensor Systems on Foil

CERN Document Server

Marien, Hagen; Heremans, Paul

2013-01-01

 This book provides insight into organic electronics technology and in analog circuit techniques that can be used to increase the performance of both analog and digital organic circuits. It explores the domain of organic electronics technology for analog circuit applications, specifically smart sensor systems.  It focuses on all the building blocks in the data path of an organic sensor system between the sensor and the digital processing block. Sensors, amplifiers, analog-to-digital converters and DC-DC converters are discussed in detail. Coverage includes circuit techniques, circuit implementation, design decisions and measurement results of the building blocks described. Offers readers the first book to focus on analog organic circuit design; Discusses organic electronics technology for analog circuit applications in the context of smart sensor systems; Describes all building blocks necessary for an organic sensor system between the sensor and the digital processing block; Includes circuit techniques, cir...

Integral equations for free-molecule ow in MEMS: recent advancements

Directory of Open Access Journals (Sweden)

Fedeli Patrick

2017-03-01

Full Text Available We address a Boundary Integral Equation (BIE approach for the analysis of gas dissipation in near-vacuum for Micro Electro Mechanical Systems (MEMS. Inspired by an analogy with the radiosity equation in computer graphics, we discuss an efficient way to compute the visible domain of integration. Moreover, we tackle the issue of near singular integrals by developing a set of analytical formulas for planar polyhedral domains. Finally a validation with experimental results taken from the literature is presented.

A Alternative Analog Circuit Design Methodology Employing Integrated Artificial Intelligence Techniques

Science.gov (United States)

Tuttle, Jeffery L.

In consideration of the computer processing power now available to the designer, an alternative analog circuit design methodology is proposed. Computer memory capacities no longer require the reduction of the transistor operational characteristics to an imprecise formulation. Therefore, it is proposed that transistor modelling be abandoned in favor of fully characterized transistor data libraries. Secondly, availability of the transistor libraries would facilitate an automated selection of the most appropriate device(s) for the circuit being designed. More specifically, a preprocessor computer program to a more sophisticated circuit simulator (e.g. SPICE) is developed to assist the designer in developing the basic circuit topology and the selection of the most appropriate transistor. Once this is achieved, the circuit topology and selected transistor data library would be downloaded to the simulator for full circuit operational characterization and subsequent design modifications. It is recognized that the design process is enhanced by the use of heuristics as applied to iterative design results. Accordingly, an artificial intelligence (AI) interface is developed to assist the designer in applying the preprocessor results. To demonstrate the retrofitability of the AI interface to established programs, the interface is specifically designed to be as non-intrusive to the host code as possible. Implementation of the proposed methodology offers the potential to speed the design process, since the preprocessor both minimizes the required number of simulator runs and provides a higher acceptance potential of the initial and subsequent simulator runs. Secondly, part count reductions may be realizable since the circuit topologies are not as strongly driven by transistor limitations. Thirdly, the predicted results should more closely match actual circuit operations since the inadequacies of the transistor models have been virtually eliminated. Finally, the AI interface

49205 ANALOGE OG DIGITALE FILTRE

DEFF Research Database (Denmark)

Gaunholt, Hans

1997-01-01

Theese lecture notes treats the fundamental theory and the most commonly used design methods for passive- active and digital filters with special emphasis on microelectronic realizations. The lecture notes covers 75% of the material taught in the course 49205 Analog and Digital Filters...

A Kolmogorov Complexity View of Analogy: From Logical Modeling to Experimentations

Science.gov (United States)

Bayoudh, Meriam; Prade, Henri; Richard, Gilles

Analogical reasoning is considered as one of the main mechanisms underlying human intelligence and creativity, allowing the paradigm shift essential to a creative process. More specific is the notion of analogical proportion like "2 is to 4 as 5 is to 10" or "read is to reader as lecture is to lecturer": such statements can be precisely described within an algebraic framework. When the proportion holds between concepts as in "engine is to car as heart is to human" or "wine is to France as beer is to England", applying an algebraic framework is less straightforward and a new way to understand analogical proportions on the basis of Kolmogorov complexity theory may seem more appropriate. This viewpoint has been used to develop a classifier detecting analogies in natural language. Despite their apparent difference, it is quite clear that the two viewpoints should be strongly related. In this paper, we investigate the link between a purely abstract view of analogical proportions and a definition based on Kolmogorov complexity theory. This theory is used as a backbone to experiment a classifier of natural language analogies whose results are consistent with the abstract setting.

Neuromimetic Sound Representation for Percept Detection and Manipulation

Directory of Open Access Journals (Sweden)

Chi Taishih

2005-01-01

Full Text Available The acoustic wave received at the ears is processed by the human auditory system to separate different sounds along the intensity, pitch, and timbre dimensions. Conventional Fourier-based signal processing, while endowed with fast algorithms, is unable to easily represent a signal along these attributes. In this paper, we discuss the creation of maximally separable sounds in auditory user interfaces and use a recently proposed cortical sound representation, which performs a biomimetic decomposition of an acoustic signal, to represent and manipulate sound for this purpose. We briefly overview algorithms for obtaining, manipulating, and inverting a cortical representation of a sound and describe algorithms for manipulating signal pitch and timbre separately. The algorithms are also used to create sound of an instrument between a "guitar" and a "trumpet." Excellent sound quality can be achieved if processing time is not a concern, and intelligible signals can be reconstructed in reasonable processing time (about ten seconds of computational time for a one-second signal sampled at . Work on bringing the algorithms into the real-time processing domain is ongoing.

Integrated multimedia information system on interactive CATV network

Science.gov (United States)

Lee, Meng-Huang; Chang, Shin-Hung

1998-10-01

In the current CATV system architectures, they provide one- way delivery of a common menu of entertainment to all the homes through the cable network. Through the technologies evolution, the interactive services (or two-way services) can be provided in the cable TV systems. They can supply customers with individualized programming and support real- time two-way communications. With a view to the service type changed from the one-way delivery systems to the two-way interactive systems, `on demand services' is a distinct feature of multimedia systems. In this paper, we present our work of building up an integrated multimedia system on interactive CATV network in Shih Chien University. Besides providing the traditional analog TV programming from the cable operator, we filter some channels to reserve them as our campus information channels. In addition to the analog broadcasting channel, the system also provides the interactive digital multimedia services, e.g. Video-On- Demand (VOD), Virtual Reality, BBS, World-Wide-Web, and Internet Radio Station. These two kinds of services are integrated in a CATV network by the separation of frequency allocation for the analog broadcasting service and the digital interactive services. Our ongoing work is to port our previous work of building up a VOD system conformed to DAVIC standard (for inter-operability concern) on Ethernet network into the current system.

The Paradox of Analogy

Directory of Open Access Journals (Sweden)

David Botting

2012-03-01

Full Text Available I will show that there is a type of analogical reasoning that instantiates a pattern of reasoning in confirmation theory that is considered at best paradoxical and at worst fatal to the entire syntactical approach to confirmation and explanation. However, I hope to elaborate conditions under which this is a sound (although not necessarily strong method of reasoning.

Development of readout electronics for monolithic integration with diode strip detectors

International Nuclear Information System (INIS)

Hosticka, B.J.; Wrede, M.; Zimmer, G.; Kemmer, J.; Hofmann, R.; Lutz, G.

1984-03-01

Parallel in - serial out analog readout electronics integrated with silicon strip detectors will bring a reduction of two orders of magnitude in external electronics. The readout concept and the chosen CMOS technology solve the basic problem of low noise and low power requirements. A hybrid solution is an intermediate step towards the final goal of monolithic integration of detector and electronics. (orig.)

Therapy with radiolabelled somatostatin analogs in neuroendocrine tumors

International Nuclear Information System (INIS)

Kunikowska, J.; Krolicki, L.

2007-01-01

In the 80's the discovery of somatostatin receptors expression on NET cells enabled the application of somatostatin analogues in diagnosis and therapy. Initially, 'cold' somatostatin analogs were used for therapeutical purpose, with overall good clinical response, but with minimal anti-proliferation effect. Furthermore, radiolabelled receptor-binding peptides have been shown to be an important class of radiopharmaceuticals for tumor diagnosis and therapy with minimal side-effects. Specific binding between receptor on tumor cell and peptide with beta emitting radionuclide act not only on tumor related symptoms but also on tumor cell via radiotoxic effect of beta radiation. Discoveries of next receptor combinations, allow the work over synthesis and applications of next receptors' analogs both in diagnosis and in therapy. Due to complex characteristics of NET's, the use therapeutic 'cocktail' containing the variety analogs may be of great importance. (author)

Using analogs to generate production forecasts in Faja

Energy Technology Data Exchange (ETDEWEB)

Garcia Lugo, Rolando A. [Repsol (Canada)

2011-07-01

In the Carabobol Block, extra heavy oil will be produced by cold production from Miocene Morical Member sands. Many parameters such as pressure, temperature, solution gas oil ratio and viscosity variation significantly impact well productivity; unfortunately little information is available on the Carabobol Block. The aim of this paper is to provide a new methodology for using analog data to develop fluid properties correlations and a future production profile. Data from the analog neighbour field in the Orinoco oil belt was used. A methodology using scatter data was successfully applied for the Carabobol Block and fluid composition, a complete PVT and an analytical forecast were found and confirmed with actual laboratory data and a gross numerical model. This study showed that analog data can be used as a first approach to assess initial reservoir conditions and fluid properties and to generate production forecasts.

Sensing Methods for Detecting Analog Television Signals