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Sample records for neurolinguistic programming nlp

  1. Working Effectively with People: Contributions of Neurolinguistic Programming (NLP) to Visual Literacy.

    Science.gov (United States)

    Ragan, Janet M.; Ragan, Tillman J.

    1982-01-01

    Briefly summarizes history of neurolinguistic programing, which set out to model elements and processes of effective communication and to reduce these to formulas that can be taught to others. Potential areas of inquiry for neurolinguistic programers which should be of concern to visual literacists are discussed. (MBR)

  2. Neuro-Linguistic Programming and Learning: Teacher Case Studies on the Impact of NLP in Education

    Science.gov (United States)

    Carey, John; Churches, Richard; Hutchinson, Geraldine; Jones, Jeff; Tosey, Paul

    2010-01-01

    This research paper reports on evidence from 24 teacher-led action research case studies and builds on the 2008 CfBT Education Trust published paper by Richard Churches and John West-Burnham "Leading learning through relationships: the implications of Neurolinguistic programming for personalisation and the children's agenda in England".…

  3. The Effect of Neuro-Linguistic Programming (NLP on Reading Comprehension in English for Specific Purposes Courses

    Directory of Open Access Journals (Sweden)

    Fahimeh Farahani

    2018-01-01

    Full Text Available Neuro-Linguistic Programming (NLP has potential to help language learners; however, it has received scant attention. The present study was an attempt to investigate the effect of NLP techniques on reading comprehension of English as a Foreign Language (EFL learners at an English for Specific Purposes (ESP course. To achieve this goal, two intact classes of students were selected to form an experimental group (n=30 and a control group (n=30. A reading pretest (based on the course content was given to all participants. The sensory learning styles of the participants were diagnosed using Reid's (1987 leaning style questionnaire, and the participants in the experimental group were familiarized with NLP techniques to be able to implement these techniques in their reading. In the control group, the conventional approach to teach ESP reading was used. Considering the analysis of posttest results through ANCOVA, it was found that implementation of NLP techniques can have significant effect on reading comprehension of Iranian undergraduate EFL learners. Pedagogical implications are discussed.

  4. Effective Communication and Neurolinguistic Programming

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    Ahsan Bashir (Corresponding Author

    2012-06-01

    Full Text Available Importance of effective communication can hardly be ignored in any sphere of life. This is achieved through various means. One such instrument is Neurolinguistic Programming (NLP which has now taken roots in various aspects of learning and education. Its potential spans education and learning, language teaching, business management and marketing, psychology, law, and several other fields. In our work, we will briefly explore various facets of NLP with special reference to effective communication.

  5. Neurolinguistic Programming in the Context of Group Counseling.

    Science.gov (United States)

    Childers, John H. Jr.; Saltmarsh, Robert E.

    1986-01-01

    Describes neurolinguistic programming (NLP) in the context of group counseling. NLP is a model of communication that focuses on verbal and nonverbal patterns of behaviors as well as on the structures and processes of human subjectivity. Five stages of group development are described, and specific NLP techniques appropriate to the various stages…

  6. Improving English Instruction through Neuro-Linguistic Programming

    Science.gov (United States)

    Helm, David Jay

    2009-01-01

    This study examines the background information and numerous applications of neuro-linguistic programming as it applies to improving English instruction. In addition, the N.L.P. modalities of eye movement, the use of predicates, and posturing are discussed. Neuro-linguistic programming presents all students of English an opportunity to reach their…

  7. Teaching Assistants, Neuro-Linguistic Programming (NLP) and Special Educational Needs: "Reframing" the Learning Experience for Students with Mild SEN

    Science.gov (United States)

    Kudliskis, Voldis

    2014-01-01

    This study examines how an understanding of two NLP concepts, the meta-model of language and the implementation of reframing, could be used to help teaching assistants enhance class-based interactions with students with mild SEN. Participants (students) completed a pre-intervention and a post-intervention "Beliefs About my Learning…

  8. Neuro-Linguistic Programming: Developing Effective Communication in the Classroom.

    Science.gov (United States)

    Torres, Cresencio; Katz, Judy H.

    Neuro-Linguistic Programming (NLP) is a method that teachers can use to increase their communication effectiveness by matching their communication patterns with those of their students. The basic premise of NLP is that people operate and make sense of their experience through information received from the world around them. This information is…

  9. Neurolinguistic Programming Examined: Imagery, Sensory Mode, and Communication.

    Science.gov (United States)

    Fromme, Donald K.; Daniell, Jennifer

    1984-01-01

    Tested Neurolinguistic Programming (NLP) assumptions by examining intercorrelations among response times of students (N=64) for extracting visual, auditory, and kinesthetic information from alphabetic images. Large positive intercorrelations were obtained, the only outcome not compatible with NLP. Good visualizers were significantly better in…

  10. Observations concerning Research Literature on Neuro-Linguistic Programming.

    Science.gov (United States)

    Einspruch, Eric L.; Forman, Bruce D.

    1985-01-01

    Identifies six categories of design and methodological errors contained in the 39 empirical studies of neurolinguistic programming (NLP) documented through April 1984. Representative reports reflecting each category are discussed. Suggestions are offered for improving the quality of research on NLP. (Author/MCF)

  11. A Qualitative Investigation into the Experience of Neuro-Linguistic Programming Certification Training among Japanese Career Consultants

    Science.gov (United States)

    Kotera, Yasuhiro

    2018-01-01

    Although the application of neuro-linguistic programming (NLP) has been reported worldwide, its scientific investigation is limited. Career consulting is one of the fields where NLP has been increasingly applied in Japan. This study explored why career consultants undertake NLP training, and what they find most useful to their practice. Thematic…

  12. Neuro-Linguistic Programming as an Innovation in Education and Teaching

    Science.gov (United States)

    Tosey, Paul; Mathison, Jane

    2010-01-01

    Neuro-linguistic programming (NLP)--an emergent, contested approach to communication and personal development created in the 1970s--has become increasingly familiar in education and teaching. There is little academic work on NLP to date. This article offers an informed introduction to, and appraisal of, the field for educators. We review the…

  13. Research Findings on Neurolinguistic Programming: Nonsupportive Data or an Untestable Theory?

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    Sharpley, Christopher F.

    1987-01-01

    Examines the experimental literature on neurolinguistic programming (NLP). Sharpley (l984) and Einspruch and Forman (l985) concluded that the effectiveness of this therapy was yet to be demonstrated. Presents data from seven recent studies that further question the basic tenets of NLP and their application in counseling situations. (Author/KS)

  14. The Effects of Clinical Hypnosis versus Neurolinguistic Programming (NLP before External Cephalic Version (ECV: A Prospective Off-Centre Randomised, Double-Blind, Controlled Trial

    Directory of Open Access Journals (Sweden)

    Joscha Reinhard

    2012-01-01

    Full Text Available Objective. To examine the effects of clinical hypnosis versus NLP intervention on the success rate of ECV procedures in comparison to a control group. Methods. A prospective off-centre randomised trial of a clinical hypnosis intervention against NLP of women with a singleton breech fetus at or after 370/7 (259 days weeks of gestation and normal amniotic fluid index. All 80 participants heard a 20-minute recorded intervention via head phones. Main outcome assessed was success rate of ECV. The intervention groups were compared with a control group with standard medical care alone (=122. Results. A total of 42 women, who received a hypnosis intervention prior to ECV, had a 40.5% (=17, successful ECV, whereas 38 women, who received NLP, had a 44.7% (=17 successful ECV (>0.05. The control group had similar patient characteristics compared to the intervention groups (>0.05. In the control group (=122 27.3% (=33 had a statistically significant lower successful ECV procedure than NLP (=0.05 and hypnosis and NLP (=0.03. Conclusions. These findings suggest that prior clinical hypnosis and NLP have similar success rates of ECV procedures and are both superior to standard medical care alone.

  15. The Effects of Clinical Hypnosis versus Neurolinguistic Programming (NLP) before External Cephalic Version (ECV): A Prospective Off-Centre Randomised, Double-Blind, Controlled Trial.

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    Reinhard, Joscha; Peiffer, Swati; Sänger, Nicole; Herrmann, Eva; Yuan, Juping; Louwen, Frank

    2012-01-01

    Objective. To examine the effects of clinical hypnosis versus NLP intervention on the success rate of ECV procedures in comparison to a control group. Methods. A prospective off-centre randomised trial of a clinical hypnosis intervention against NLP of women with a singleton breech fetus at or after 37(0/7) (259 days) weeks of gestation and normal amniotic fluid index. All 80 participants heard a 20-minute recorded intervention via head phones. Main outcome assessed was success rate of ECV. The intervention groups were compared with a control group with standard medical care alone (n = 122). Results. A total of 42 women, who received a hypnosis intervention prior to ECV, had a 40.5% (n = 17), successful ECV, whereas 38 women, who received NLP, had a 44.7% (n = 17) successful ECV (P > 0.05). The control group had similar patient characteristics compared to the intervention groups (P > 0.05). In the control group (n = 122) 27.3% (n = 33) had a statistically significant lower successful ECV procedure than NLP (P = 0.05) and hypnosis and NLP (P = 0.03). Conclusions. These findings suggest that prior clinical hypnosis and NLP have similar success rates of ECV procedures and are both superior to standard medical care alone.

  16. Neurolinguistic programming: a systematic approach to change.

    Science.gov (United States)

    Steinbach, A M

    1984-01-01

    Neurolinguistic programming (NLP) integrates advances in cybernetics, psychophysiology, linguistics, and information services. It has been used in business, education, law, medicine and psychotherapy to alter people's responses to stimuli, so they are better able to regulate their environment and themselves. There are five steps to an effective NLP interaction. They include 1. establishing rapport; the therapist must match his verbal and non-verbal behaviors to the patient's, 2. gathering information about the patient's present problem and goals by noting his verbal patterns and non-verbal responses, 3. considering the impact that achieving the patient's goals will have on him, his work, family and friends, and retaining any positive aspects of his current situation, 4. helping the patient achieve his goals by using specific techniques to alter his responses to various stimuli, and 5. ensuring the altered responses achieved in therapy are integrated into the patient's daily life. NLP has been used to help patients with medical problems ranging from purely psychological to complex organic ones.

  17. Visual displays and Neuro-Linguistic Programming

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    Brown-VanHoozer, S.A. [Argonne National Lab., Idaho Falls, ID (United States); VanHoozer, W.R. [Tranceformations Unlimited, Rigby, ID (United States)

    1994-10-01

    Advancement of computer technology is forthcoming at such a rapid pace that the research concerning the interplay of humans and computer technology is lagging far behind. One area of particular concern is the design of visual displays that are pragmatic, ``user friendly,`` and ``user assisting.`` When engineers design visual displays, they generally do so methodically and logically, but only from within their own individual perspective or ``model of the world.`` They select the human aspects which make sense to them and not necessarily to non-engineers, operators, and others. The model design is what the engineer chooses to relate, based on his or her perspective of reality. These choices limit the model design thereby excluding the users` perspective. A set of techniques which can be used to assist the designers in expanding their choices and include the users` model is Neuro-Linguistic Programming (NLP).

  18. Neuro-linguistic programming and application in treatment of phobias.

    Science.gov (United States)

    Karunaratne, Mahishika

    2010-11-01

    Phobias are a prevalent and often debilitating mental health problem all over the world. This article aims to explore what is known about the use of Neuro-linguistic Programming (NLP) as a treatment for this condition. Whilst there is abundant experiential evidence from NLP practitioners attesting to the efficacy of this method as a treatment for phobias, experimental research in this area is somewhat limited. This paper reviews evidence available in literature produced in the UK and US and reveals that NLP is a successful treatment for phobias as well as being particularly efficient due to the relatively brief time period it takes to effect an improvement. Copyright © 2010 Elsevier Ltd. All rights reserved.

  19. Investigating the Relationship between Iranian EFL Teachers' Autonomy and Their Neuro-Linguistic Programming

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    Hosseinzadeh, Ehsan; Baradaran, Abdollah

    2015-01-01

    The present study was an attempt to investigate the relationship between English Language Teachers' autonomy and their Neuro-linguistic Programming (NLP). To this end, a group of 200 experienced English language teachers at various language schools in Tehran, inter alia, Asre Zaban Language Academy, were given two questionnaires namely Teaching…

  20. The Effect of Neurolinguistic Programming on Organisational and Individual Performance: A Case Study.

    Science.gov (United States)

    Thompson, John E.; Courtney, Lisa; Dickson, D.

    2002-01-01

    A longitudinal evaluation measured the effects of neurolinguistic programming (NLP) on 67 hospitality worker immediately before and after and 6 weeks and 6 months after training. Positive increases in interpersonal communication appeared after 6 weeks, leveling off or declining after 6 months. Self-efficacy, self-esteem, and adaptive selling…

  1. Gender Differences in the Primary Representational System according to Neurolinguistic Programming.

    Science.gov (United States)

    Cassiere, M. F.; And Others

    Neurolinguistic Programming (NLP) is a currently popular therapeutic modality in which individuals organize information through three basic sensory systems, one of which is the Primary Representational System (PRS). This study was designed to investigate gender differences in PRS according to the predicate preference method. It was expected that…

  2. Neurolinguistic programming: a systematic review of the effects on health outcomes.

    Science.gov (United States)

    Sturt, Jackie; Ali, Saima; Robertson, Wendy; Metcalfe, David; Grove, Amy; Bourne, Claire; Bridle, Chris

    2012-11-01

    Neurolinguistic programming (NLP) in health care has captured the interest of doctors, healthcare professionals, and managers. To evaluate the effects of NLP on health-related outcomes. Systematic review of experimental studies. The following data sources were searched: MEDLINE, PsycINFO, ASSIA, AMED, CINAHL, Web of Knowledge, CENTRAL, NLP specialist databases, reference lists, review articles, and NLP professional associations, training providers, and research groups. Searches revealed 1459 titles from which 10 experimental studies were included. Five studies were randomised controlled trials (RCTs) and five were pre-post studies. Targeted health conditions were anxiety disorders, weight maintenance, morning sickness, substance misuse, and claustrophobia during MRI scanning. NLP interventions were mainly delivered across 4-20 sessions although three were single session. Eighteen outcomes were reported and the RCT sample sizes ranged from 22 to 106. Four RCTs reported no significant between group differences with the fifth finding in favour of the NLP arm (F = 8.114, P<0.001). Three RCTs and five pre-post studies reported within group improvements. Risk of bias across all studies was high or uncertain. There is little evidence that NLP interventions improve health-related outcomes. This conclusion reflects the limited quantity and quality of NLP research, rather than robust evidence of no effect. There is currently insufficient evidence to support the allocation of NHS resources to NLP activities outside of research purposes.

  3. [Neurolinguistic programming in physician-patient communication. Basic principles of the procedure--examples for application in surgery].

    Science.gov (United States)

    Graf, U

    1995-09-20

    Neurolinguistic programming (NLP) is a means of improving physician-patient communication that can be learned by any doctor. The present article first describes some of the fundamentals of NLP and then provides examples taken from the field of surgery-in the first instance dealing with the treatment of painful conditions by means of trance or dissociation and, secondly, on the influencing of expectations and the restructuring (reframing) of doctrines in a patient with malignant disease.

  4. Validation of Eye Movements Model of NLP through Stressed Recalls.

    Science.gov (United States)

    Sandhu, Daya S.

    Neurolinguistic Progamming (NLP) has emerged as a new approach to counseling and psychotherapy. Though not to be confused with computer programming, NLP does claim to program, deprogram, and reprogram clients' behaviors with the precision and expedition akin to computer processes. It is as a tool for therapeutic communication that NLP has rapidly…

  5. Neurolinguistic Programming in Orientation and Mobility.

    Science.gov (United States)

    Williams, M. F.; Jacobson, W. H.

    1989-01-01

    The article describes the neurolinguistic programing model and applies it to teaching orientation and mobility skills to congenitally blind students, who have access to only the auditory and kinesthetic primary systems. Understanding the effects on thought of limited representational systems can help trainers teach more effective cane or dog guide…

  6. Sensory submodalities testing in neurolinguistic programming, part of mental training

    Directory of Open Access Journals (Sweden)

    Vlad Teodor GROSU

    2017-03-01

    Full Text Available Introduction: this study is part of a larger work, which involves increasing sporting performance by applying mental training techniques – special techniques of neurolinguistic programming. In this case we will discuss some aspects of the test application Jacobson S. (2011. Purpose of study and hypothesis: In neurolinguistic programming (NLP we have studied the relationship between sensory submodalities, in accordance with the Jacobson test (2011. We wanted to check the degree of significance of the mean difference parameters studied and if the materiality result falls within the objective parameters. If ideomotor representations of athletes are completed with multiple sensations of all sensory submodalities such as visual, auditory, kinesthetic, olfactory and gustatory, the possibility of applying the techniques of NLP (neurolinguistic programming will have more effective results. Methods and material: two records were made by using two tests, test1 and test2 on master students of the University “Babes-Bolyai” Cluj-Napoca, from FEFS from APS department (training and sports performance. The statistical indicators were calculated on elements of descriptive statistics and the data is presented using indicators of centrality, location and distribution. Statistical analysis of non-parametric Wilcoxon test was used for sample pairs (data uneven distribution/rank. Materiality tests used was α=0.05 (5%, α=0.01 (1% or α=0.001. Results and deliberations: to detect the correlation between the two variables we used the Spearman rank correlation coefficient (ρ. Statistical analysis was performed using the correlation coefficients Colton’s rule. It was found that no statistically significant differences were observed (p>0.05 in the statistical analysis of sample pairs Jacobson test values (times T1-T2. This is a result of the short timeframe – just one month – for objectives reasons. However, many of them appear in a good and a very good

  7. NLP

    DEFF Research Database (Denmark)

    Krogsdal, Iben

    2007-01-01

    Artiklen søger at problematisere forståelsen af terapiformen NLP (Neuro Linguistisk Programmering) som fremelsker af selvstyrende individer. Den viser, hvordan NLP - gennem sin underliggende fortælling om det autentiske menneske som ideal - fordrer et fortsat selvudviklingarbejde via terapeutisk...... intervention. NLP-praksis kan derfor anskues som en løbende bemyndigelsesproces, hvor klientens selvforståelse først afvises som uautentisk hvorefter en ny selvforståelse installeres gennem terapeutiske tolkninger af "det ubevidste"....

  8. Bibliography of Literature on Neuro-Linguistic Programming.

    Science.gov (United States)

    McCormick, Donald W.

    Two bibliographies on neurolinguistic programming are updates of an earlier literature review by the same compiler. The two lists contain citations of over 160 books, research reports, dissertations, journal articles, audio and video recordings, and research projects in progress on aspects of neurolinguistic programming. Appended notes suggest…

  9. Weight maintenance through behaviour modification with a cooking course or neurolinguistic programming.

    Science.gov (United States)

    Sørensen, Lone Brinkmann; Greve, Tine; Kreutzer, Martin; Pedersen, Ulla; Nielsen, Claus Meyer; Toubro, Søren; Astrup, Arne

    2011-01-01

    We compared the effect on weight regain of behaviour modification consisting of either a gourmet cooking course or neurolinguistic programming (NLP) therapy. Fifty-six overweight and obese subjects participated. The first step was a 12-week weight loss program. Participants achieving at least 8% weight loss were randomized to five months of either NLP therapy or a course in gourmet cooking. Follow-up occurred after two and three years. Forty-nine participants lost at least 8% of their initial body weight and were randomized to the next step. The NLP group lost an additional 1.8 kg and the cooking group lost 0.2 kg during the five months of weight maintenance (NS). The dropout rate in the cooking group was 4%, compared with 26% in the NLP group (p=0.04). There was no difference in weight maintenance after two and three years of follow-up. In conclusion, weight loss in overweight and obese participants was maintained equally efficiently with a healthy cooking course or NLP therapy, but the dropout rate was lower during the active cooking treatment.

  10. Training in Influencing Skills from Neuro-Linguistic Programming (Modelled from Hypnosis and Family Therapy), in Combination with Innovative Maths Pedagogy, Raises Maths Attainment in Adult Numeracy Learners

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    Allan, F.; Bourne, J.; Bouch, D.; Churches, R.; Dennison, J.; Evans, J.; Fowler, J.; Jeffers, A.; Prior, E.; Rhodes, L.

    2012-01-01

    Case study research suggests that NLP [neuro-linguistic programming] influencing strategies benefit teacher effectiveness. Maths pedagogy involving higher-order questioning, challenge, problem solving and collaborative working may be a way of improving attainment in adult numeracy learning, however, such strategies may be less effective if the…

  11. The Old Brain, the New Mirror: Matching Teaching and Learning Styles in Foreign Language Class (Based on Neuro-Linguistic Programming).

    Science.gov (United States)

    Knowles, John K.

    The process of matching teaching materials and methods to the student's learning style and ability level in foreign language classes is explored. The Neuro-Linguistic Programming (NLP) model offers a diagnostic process for the identification of style. This process can be applied to the language learning setting as a way of presenting material to…

  12. Using an imaginary scrapbook for neurolinguistic programming in the aftermath of a clinical depression: a case history.

    Science.gov (United States)

    Hossack, A; Standidge, K

    1993-04-01

    We employed neurolinguistic programming (NLP) principles to develop a positive self-identity in an elderly male patient in England recovering from clinical depression. This novel technique encouraged recall of intrinsically rewarding past experiences. Each experience was conceptualized in an image and compiled chronologically in an imaginary book, providing continuity to what were chaotic and fragmented recollections during the immediate postdepressive stage. The patient's anxiety and depression were alleviated and his own functional goals largely realized.

  13. The relationship between hypnotizability, internal imagery, and efficiency of neurolinguistic programming.

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    Kirenskaya, Anna V; Novototsky-Vlasov, Vladimir Y; Chistyakov, Andrey N; Zvonikov, Vyacheslav M

    2011-04-01

    Subjective scoring and autonomic variables (heart rate, skin conduction span) were used to verify the reality of inner experience during recollection of emotionally neutral, positive, and negative past events in 19 high (HH) and 12 low (LH) hypnotizable subjects in hypnotic and nonhypnotic experimental sessions. Also, the influence of hypnotizability on the effectiveness of an imagery-based neurolinguistic programming (NLP) technique was evaluated. Results demonstrated that subjective scores of image vividness and emotional intensity were significantly higher in the HH subjects compared to LH in both sessions. The past-events recollection was followed by increased autonomic activity only in the HH subjects. The NLP procedure was followed by decreased negative emotional intensity in both groups, but autonomic activity decline was observed in the HH subjects and not in the LH.

  14. Using Neurolinguistic Programming: Some Suggestions for the Remedial Teacher.

    Science.gov (United States)

    Burton, Grace M.

    1986-01-01

    The use of neurolinguistic programming techniques is suggested as a means of enhancing rapport with students. Mirroring, digital mirroring, analog mirroring, metaphors, knowing persons, and how these aid in presenting content are each discussed. (MNS)

  15. The bumper bundle book of modelling NLP modelling made simple

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    Burgess, Fran

    2014-01-01

    A Neurolinguistic Programming textbook which focusses on the core activity of NLP - modelling. It covers the thinking behind NLP modelling, presents an extensive range of modelling methodologies and skills, offers applications of modelling, and provides specific details for model and technique construction.

  16. The Role of NLP in Teachers' Classroom Discourse

    Science.gov (United States)

    Millrood, Radislav

    2004-01-01

    Neuro-linguistic programming (NLP) is an approach to language teaching which is claimed to help achieve excellence in learner performance. Yet there is little evidence of the impact that NLP techniques in teachers' discourse can have on learners. The article draws on workshops with teachers where classroom simulations were used to raise teachers'…

  17. The Eyes Don’t Have It: Lie Detection and Neuro-Linguistic Programming

    Science.gov (United States)

    Wiseman, Richard; Watt, Caroline; ten Brinke, Leanne; Porter, Stephen; Couper, Sara-Louise; Rankin, Calum

    2012-01-01

    Proponents of Neuro-Linguistic Programming (NLP) claim that certain eye-movements are reliable indicators of lying. According to this notion, a person looking up to their right suggests a lie whereas looking up to their left is indicative of truth telling. Despite widespread belief in this claim, no previous research has examined its validity. In Study 1 the eye movements of participants who were lying or telling the truth were coded, but did not match the NLP patterning. In Study 2 one group of participants were told about the NLP eye-movement hypothesis whilst a second control group were not. Both groups then undertook a lie detection test. No significant differences emerged between the two groups. Study 3 involved coding the eye movements of both liars and truth tellers taking part in high profile press conferences. Once again, no significant differences were discovered. Taken together the results of the three studies fail to support the claims of NLP. The theoretical and practical implications of these findings are discussed. PMID:22808128

  18. The eyes don't have it: lie detection and Neuro-Linguistic Programming.

    Directory of Open Access Journals (Sweden)

    Richard Wiseman

    Full Text Available Proponents of Neuro-Linguistic Programming (NLP claim that certain eye-movements are reliable indicators of lying. According to this notion, a person looking up to their right suggests a lie whereas looking up to their left is indicative of truth telling. Despite widespread belief in this claim, no previous research has examined its validity. In Study 1 the eye movements of participants who were lying or telling the truth were coded, but did not match the NLP patterning. In Study 2 one group of participants were told about the NLP eye-movement hypothesis whilst a second control group were not. Both groups then undertook a lie detection test. No significant differences emerged between the two groups. Study 3 involved coding the eye movements of both liars and truth tellers taking part in high profile press conferences. Once again, no significant differences were discovered. Taken together the results of the three studies fail to support the claims of NLP. The theoretical and practical implications of these findings are discussed.

  19. Efficacy of neurolinguistic programming training on mental health in nursing and midwifery students.

    Science.gov (United States)

    Sahebalzamani, Mohammad

    2014-09-01

    Neurolinguistic programming (NLP) refers to the science and art of reaching success and perfection. It is a collection of the skills based on human beings' psychological characteristics through which the individuals obtain the ability to use their personal capabilities as much as possible. This study aimed to investigate the efficacy of NLP training on mental health in nursing and midwifery students in Islamic Azad University Tehran Medical Sciences branch. In this quasi-experimental study, the study population comprised all nursing and midwifery students in Islamic Azad University, Tehran Medical branch, of whom 52 were selected and assigned to two groups through random sampling. Data collection tool was Goldberg General Health Questionnaire (28-item version). After primary evaluation, NLP training was given in five 120-min sessions and the groups were re-evaluated. The obtained data were analyzed. In the nursing group, paired t-test showed a significant difference in the scores of mental health (with 39 points decrease), physical signs (with 7.96 scores decrease), anxiety (with 10.75 scores decrease), social function (with 7.05 scores decrease) and depression (with 9.38 scores decrease). In the midwifery group, it showed a significant difference in mental health (with 22.63 scores decrease), physical signs (with 6.54 scores decrease), anxiety (with nine scores decrease), and depression (with 8.38 scores decrease). This study showed that NLP strategies are effective in the improvement of general health and its various dimensions. Therefore, it is essential to conduct structured and executive programs concerning NLP among the students.

  20. Neurolinguistic programming as an adjunct to other psychotherapeutic/hypnotherapeutic interventions.

    Science.gov (United States)

    Field, E S

    1990-01-01

    The therapeutic dissociative techniques of "anchoring" and "three-part dissociation," neurolinguistic programming (NLP) treatment paradigms incorporating the idea of division into ego states, are effective in crisis intervention and as a stimulus for catharsis. Using the anchoring technique in the first session, a patient with severe anxiety, manifested by episodes of hyperactivity, was able to superimpose inner resources upon the situations which led to the episodes. Utilizing three-part dissociation, the patient experienced the hyperactive episodes "for the very last time" and terminated them permanently. Hypnotic exploration and ideomotor signaling were used with a patient presenting with uncomfortable feelings associated with intense anger. After the origin of the anger was determined, a three-part dissociation produced an abreaction and catharsis. Interaction at a cognitive level integrated the feelings and knowledge into personal consciousness.

  1. Neuro-Linguistic Programming Treatment for Anxiety: Magic or Myth?

    Science.gov (United States)

    Krugman, Martin; And Others

    1985-01-01

    Compared neuro-linguistic programing treatment for anxiety with self-control desensitization of equal duration and a waiting-list control group in treating public speaking anxiety. Results indicated that neither treatment was more effective in reducing anxiety than merely waiting for one hour. (Author/MCF)

  2. Neuro-Linguistic Programming: Enhancing Teacher-Student Communications.

    Science.gov (United States)

    Childers, John H., Jr.

    1985-01-01

    Defines Neurolinguistic Programming (NCP) and discusses specific dimensions of the model that have applications for classroom teaching. Describes five representational systems individuals use to process information and gives examples of effective and ineffective teacher-student communication for each system. (MCF)

  3. Neuro-Linguistics Programming: Developing Effective Communication in the Classroom.

    Science.gov (United States)

    Torres, Cresencio; Katz, Judy H.

    1983-01-01

    Students and teachers experience the world primarily through visual, kinesthetic, or auditory representational systems. If teachers are aware of their own favored system and those of their students, classroom communication will improve. Neurolinguistic programing can help teachers become more effective communicators. (PP)

  4. Predicate Matching in NLP: A Review of Research on the Preferred Representational System.

    Science.gov (United States)

    Sharpley, Christopher F.

    1984-01-01

    Reviews 15 studies that have investigated the use of the Preferred Representational System (PRS) in Neurolinguistic Programming (NLP). Aspects of design, methodology, population and dependent measures are evaluated, with comments on the outcomes obtained. Results suggested that there is little supportive evidence for the use of PRS in the NLP.…

  5. Impact of the application of neurolinguistic programming to mothers of children enrolled in a day care center of a shantytown.

    Science.gov (United States)

    de Miranda, C T; de Paula, C S; Palma, D; da Silva, E M; Martin, D; de Nóbrega, F J

    1999-03-04

    Of the members of a family, the mother is without doubt the most important one, which provides justification for including an evaluation of her mental health as one of the variables to be considered as determining factors in each child's level of development. To assess the impact of the application of Neurolinguistic Programming (NLP) on child development, home environment and maternal mental health. Randomised controlled trial. The study included children enrolled in the municipal day care center of a shantytown in the City of São Paulo. 45 pairs of mothers and respective children between 18 and 36 months of age. Children's development (Bayley scales); home environment variation (HOME); and maternal mental health (SRQ). Comparison between before and after the intervention was made in terms of children's psychomotor development, home environment and maternal mental health. Application of the NLP technique to the experimental group and comparison with a control group. 1--Experimental (EG), consisting of 23 children submitted to intervention by NLP; and 2--Control (CG), with 22 children with no intervention. Length of intervention: 15 sessions of NLP. 37 children remained in the study (EG = 10, CG = 27). Variations in mental development (OR 1.21, IC 95% 0.0 to 23.08) in their home environment (Wilcoxon): p = 0.96 (before) and p = 0.09 (after); in maternal mental health: p = 0.26, 2 df. There was a trend that indicated positive effects on the home environment from the intervention.

  6. PENERAPAN HIPNOTEACHING MELALUI NEURO-LINGUISTIC PROGRAMMING DALAM PEMBELAJARAN KIMIA

    Directory of Open Access Journals (Sweden)

    S. Ismuzaroh

    2013-10-01

    Full Text Available Tujuan penerapan hypnoteaching melalui neuro linguistic programming (NLP dalam proses pembelajaran kimia adalah untuk menghilangkan pikiran negatif siswa terhadap pembelajaran kimia, yang selanjutnya meningkatkan minat, motivasi dan keaktifan belajar kimia siswa. Hasil penelitian menunjukkan siswa lebih terbuka, berani mengemukakan pendapat terhadap permasalahan kimia yang pelajari, siswa merasa fresh, dan nyaman. Hypnoteaching goals through the application of neuro linguistic programming (NLP is a chemical in the learning process to eliminate the negative thoughts of students towards learning chemistry, which further increase the interest, motivation and active learning chemistry students. Results showed students were more open, daring to express opinions on issues studied chemistry, students feel fresh, and comfortable.

  7. Neuro-Linguistic Programming: Human Technology for Today’s Air Force.

    Science.gov (United States)

    1986-04-01

    Part III, pp. 4-5. ’ 26. Ibid, p. 6. 27. Donald W. McCormick, " Neurolinguistic Programming: A Resource Guide and Review of the Research, The 1984...Carol Johnson, " Neurolinguistic Programming--Mystique or Mistake?" Army Organizational Effectiveness Journal, No. 1, 1985, pp. 74-80. 29. Dilts

  8. The effect of neuro-linguistic programming on occupational stress in critical care nurses

    National Research Council Canada - National Science Library

    HemmatiMaslakpak, Masumeh; Farhadi, Masumeh; Fereidoni, Javid

    2016-01-01

    .... Nero-linguistic programming (NLP) is one of the modern methods of psychotherapy. This study aimed to determine the effect of NLP on occupational stress in nurses working in critical care units of Urmia...

  9. Hypothesized eye movements of neurolinguistic programming: a statistical artifact.

    Science.gov (United States)

    Farmer, A; Rooney, R; Cunningham, J R

    1985-12-01

    Neurolinguistic programming's hypothesized eye-movements were measured independently from videotapes of 30 subjects, aged 15 to 76 yr., who were asked to recall visual pictures, recorded audio sounds, and textural objects. chi 2 indicated that subjects' responses were significantly different from those predicted. When chi 2 comparisons were weighted by number of eye positions assigned to each modality (3 visual, 3 auditory, 1 kinesthetic), subjects' responses did not differ significantly from the expected pattern. These data indicate that the eye-movement hypothesis may represent randomly occurring rather than sensory-modality-related positions.

  10. Neurolinguistic programming training, trait anxiety, and locus of control.

    Science.gov (United States)

    Konefal, J; Duncan, R C; Reese, M A

    1992-06-01

    Training in the neurolinguistic programming techniques of shifting perceptual position, visual-kinesthetic dissociation, timelines, and change-history, all based on experiential cognitive processing of remembered events, leads to an increased awareness of behavioral contingencies and a more sensitive recognition of environmental cues which could serve to lower trait anxiety and increase the sense of internal control. This study reports on within-person and between-group changes in trait anxiety and locus of control as measured on the Spielberger State-Trait Anxiety Inventory and Wallston, Wallston, and DeVallis' Multiple Health Locus of Control immediately following a 21-day residential training in neurolinguistic programming. Significant with-in-person decreases in trait-anxiety scores and increases in internal locus of control scores were observed as predicted. Chance and powerful other locus of control scores were unchanged. Significant differences were noted on trait anxiety and locus of control scores between European and U.S. participants, although change scores were similar for the two groups. These findings are consistent with the hypothesis that this training may lower trait-anxiety scores and increase internal locus of control scores. A matched control group was not available, and follow-up was unfortunately not possible.

  11. Impact of the application of neurolinguistic programming to mothers of children enrolled in a day care center of a shantytown

    Directory of Open Access Journals (Sweden)

    Cláudio Torres de Miranda

    1999-03-01

    Full Text Available CONTEXT: Of the members of a family, the mother is without doubt the most important one, which provides justification for including an evaluation of her mental health as one of the variables to be considered as determining factors in each child’s level of development. OBJECTIVE: To assess the impact of the application of Neurolinguistic Programming (NLP on child development, home environment and maternal mental health. DESIGN: Randomised controlled trial. SETTING: The study included children enrolled in the municipal day care center of a shantytown in the City of São Paulo. PARTICIPANTS: 45 pairs of mothers and respective children between 18 and 36 months of age. MAIN MEASUREMENTS: Children’s development (Bayley scales; home environment variation (HOME; and maternal mental health (SRQ. Comparison between before and after the intervention was made in terms of children’s psychomotor development, home environment and maternal mental health. INTERVENTION: Application of the NLP technique to the experimental group and comparison with a control group. 1 - Experimental (EG, consisting of 23 children submitted to intervention by NLP; and 2 - Control (CG, with 22 children with no intervention. Length of intervention: 15 sessions of NLP. RESULTS: 37 children remained in the study (EG = 10, CG = 27. Variations in mental development (OR 1.21, IC 95% 0.0 to 23.08 in their home environment (Wilcoxon: p = 0.96 (before and p = 0.09 (after; in maternal mental health: p = 0.26, 2 df. CONCLUSIONS: There was a trend that indicated positive effects on the home environment from the intervention.

  12. Neurolinguistic programming used to reduce the need for anaesthesia in claustrophobic patients undergoing MRI

    National Research Council Canada - National Science Library

    Bigley, J; Griffiths, P D; Prydderch, A; Romanowski, C A J; Miles, L; Lidiard, H; Hoggard, N

    2010-01-01

    The purpose of this study was to assess the success of neurolinguistic programming in reducing the need for general anaesthesia in claustrophobic patients who require MRI and to consider the financial...

  13. Neurolinguistic programming used to reduce the need for anaesthesia in claustrophobic patients undergoing MRI

    Science.gov (United States)

    Bigley, J; Griffiths, P D; Prydderch, A; Romanowski, C A J; Miles, L; Lidiard, H; Hoggard, N

    2010-01-01

    The purpose of this study was to assess the success of neurolinguistic programming in reducing the need for general anaesthesia in claustrophobic patients who require MRI and to consider the financial implications for health providers. This was a prospective study performed in 2006 and 2007 at a teaching hospital in England and comprised 50 adults who had unsuccessful MR examinations because of claustrophobia. The main outcome measures were the ability to tolerate a successful MR examination after neurolinguistic programming, the reduction of median anxiety scores produced by neurolinguistic programming, and models of costs for various imaging pathways. Neurolinguistic programming allowed 38/50 people (76%) to complete the MR examination successfully. Overall, the median anxiety score was significantly reduced following the session of neurolinguistic programming. In conclusion, neurolinguistic programming reduced anxiety and subsequently allowed MRI to be performed without resorting to general anaesthesia in a high proportion of claustrophobic adults. If these results are reproducible, there will be major advantages in terms of patient safety and costs. PMID:19505969

  14. Neurolinguistic programming used to reduce the need for anaesthesia in claustrophobic patients undergoing MRI.

    Science.gov (United States)

    Bigley, J; Griffiths, P D; Prydderch, A; Romanowski, C A J; Miles, L; Lidiard, H; Hoggard, N

    2010-02-01

    The purpose of this study was to assess the success of neurolinguistic programming in reducing the need for general anaesthesia in claustrophobic patients who require MRI and to consider the financial implications for health providers. This was a prospective study performed in 2006 and 2007 at a teaching hospital in England and comprised 50 adults who had unsuccessful MR examinations because of claustrophobia. The main outcome measures were the ability to tolerate a successful MR examination after neurolinguistic programming, the reduction of median anxiety scores produced by neurolinguistic programming, and models of costs for various imaging pathways. Neurolinguistic programming allowed 38/50 people (76%) to complete the MR examination successfully. Overall, the median anxiety score was significantly reduced following the session of neurolinguistic programming. In conclusion, neurolinguistic programming reduced anxiety and subsequently allowed MRI to be performed without resorting to general anaesthesia in a high proportion of claustrophobic adults. If these results are reproducible, there will be major advantages in terms of patient safety and costs.

  15. Applying "What Works" in Psychology to Enhancing Examination Success in Schools: The Potential Contribution of NLP

    Science.gov (United States)

    Kudliskis, Voldis; Burden, Robert

    2009-01-01

    The strengths and weaknesses of Neuro-Linguistic Programming (NLP) are described with reference to its origins, previous research and comments from critics and supporters. A case is made for this allegedly theoretical approach to provide the kind of outcomes focused intervention that psychology and psychologists can offer to schools. In…

  16. THE PROGRAMMING NEURO-LINGUISTICS AND THEIR APPLICABILITY IN THE PROCESS OF RECRUITMENT AND SELECTION

    Directory of Open Access Journals (Sweden)

    Gilma Álamo Sánchez

    2008-04-01

    Full Text Available He/she is carried out a study referred to tools of Programming Neuro-linguistics (PNL for the Selection, Employment and Training that allow choosing the appropriate personnel taking the language and the behavior as a result. For their development theories were revised referred to the PNL and the recruitment process and selection sustained in the process of the interview. The summations are oriented to the importance and convenience for the Management of Human resources of applying the Programming Neuro-linguistics as selection tool of personal. Finally it is recommended to apply the proposal inside the mark of adaptability according to the necessities and demands of each organization.

  17. Effect of neurolinguistic programming training on self-actualization as measured by the Personal Orientation Inventory.

    Science.gov (United States)

    Duncan, R C; Konefal, J; Spechler, M M

    1990-06-01

    Neurolinguistic programming training is based on principles that should enable the trainee to be more "present"-oriented, inner-directed, flexible, self-aware, and responsive to others, that is, more self-actualized. This study reports within-person changes on self-actualization measures of the Personal Orientation Inventory following a 24-day residential training in neurolinguistic programming. Significant positive mean changes were found for 18 master practitioners on nine of the 12 scales and for 36 practitioners on 10 of the 12 scales. Findings are consistent with the hypothesis that training increases individual self-actualization scores.

  18. Neurolinguistic Programming: Add It To Your Tool Chest of Interpretive Techniques.

    Science.gov (United States)

    Parratt, Smitty

    1997-01-01

    Highlights the importance of using verbal and nonverbal neurolinguistic programming to maximize the potential of interactions between interpreters and the general public and to improve long-term interactions. Discusses the power of mirroring and representational systems. Contains 29 references. (JRH)

  19. Assessment of Primary Representational Systems with Neurolinguistic Programming: Examination of Preliminary Literature.

    Science.gov (United States)

    Dorn, Fred J.; And Others

    1983-01-01

    Reviews the inconsistent findings of studies on neurolinguistic programing and recommends some areas that should be examined to verify various claims. Discusses methods of assessing client's primary representational systems, including predicate usage and eye movements, and suggests that more reliable methods of assessing PRS must be found. (JAC)

  20. Assessing Primary Representational System (PRS) Preference for Neurolinguistic Programming (NLP) Using Three Methods.

    Science.gov (United States)

    Dorn, Fred J.

    1983-01-01

    Considered three methods of identifying Primary Representational System (PRS)--an interview, a word list, and a self-report--in a study of 120 college students. Results suggested the three methods offer little to counselors either collectively or individually. Results did not validate the PRS construct, suggesting the need for further research.…

  1. THE PROGRAMMING NEURO-LINGUISTICS AND THEIR APPLICABILITY IN THE PROCESS OF RECRUITMENT AND SELECTION

    OpenAIRE

    Gilma Álamo Sánchez; Yuhane Sangronis

    2008-01-01

    He/she is carried out a study referred to tools of Programming Neuro-linguistics (PNL) for the Selection, Employment and Training that allow choosing the appropriate personnel taking the language and the behavior as a result. For their development theories were revised referred to the PNL and the recruitment process and selection sustained in the process of the interview. The summations are oriented to the importance and convenience for the Management of Human resources of applying the Progra...

  2. Comparison for aphasic and control subjects of eye movements hypothesized in neurolinguistic programming.

    Science.gov (United States)

    Dooley, K O; Farmer, A

    1988-08-01

    Neurolinguistic programming's hypothesized eye movements were measured independently using videotapes of 10 nonfluent aphasic and 10 control subjects matched for age and sex. Chi-squared analysis indicated that eye-position responses were significantly different for the groups. Although earlier research has not supported the hypothesized eye positions for normal subjects, the present findings support the contention that eye-position responses may differ between neurologically normal and aphasic individuals.

  3. MODEL PEMBELAJARAN NEUROLINGUISTIC PROGRAMMING BERORIENTASI KARAKTER BAGI PENINGKATAN KEMAMPUAN MENULIS SISWA SMP

    Directory of Open Access Journals (Sweden)

    Wikanengsih -

    2014-06-01

    Abstrak: Model Pembelajaran Neurolinguistic Programming Berorientasi Karakter untuk Mening­katkan Kemampuan Menulis Siswa. Penelitian ini bertujuan untuk mengetahui keefektifan model pem­belajaran neurolinguistik programming berorientasi karakter (MPNLPBK terhadap kemampuan menulis siswa. Metode penelitian yang digunakan metode penelitian kombinasi (mixed method jenis sequential exploratory strategy. Hasil penelitian tahap pertama (penelitian kualitatif menghasilkan model pembelajaran hipotetik. Penelitian tahap kedua merupakan uji coba penerapan model hipotetik (penelitian kuantitatif. Hasil pengujian menunjukkan bahwa pembelajaran menulis dengan menggunakan MPNLPBK dapat meningkatkan kemampuan menulis siswa kelompok eksperimen. Selain itu, berdasarkan hasil pengamatan terhadap aspek karakter komunikatif, toleran, tanggungjawab dan kreatif siswa, terdapat perkembangan pada diri siswa untuk setiap aspek tersebut.

  4. Wykorzystanie metod programowania neurolingwistycznego (NLP w kształtowaniu kultury organizacyjnej biblioteki

    Directory of Open Access Journals (Sweden)

    Katarzyna Pilitowska

    2007-01-01

    Full Text Available Neuro-linguistic programming is one of many methods used in the West to influence people’s attitudes towards work, their way of thinking and the motivation to work. Its originality stems from the fact that the method appeals in the main to non-material values such us: service orientation, social usefulness of one’s work, the sense of duty and satisfaction it gives, the resulting feeling of one’s high self-esteem. The NLP is included in the broadly-understood organizational culture applied in a given firm or an institution. The author maintains that thus understood neuro-linguistic programming can find its application in modem library practice and significantly improve modernization processes within its organizational culture.

  5. Speaker Recognition Through NLP and CWT Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Brown-VanHoozer, S.A.; Kercel, S.W.; Tucker, R.W.

    1999-06-16

    The objective of this research is to develop a system capable of identifying speakers on wiretaps from a large database (>500 speakers) with a short search time duration (<30 seconds), and with better than 90% accuracy. Much previous research in speaker recognition has led to algorithms that produced encouraging preliminary results, but were overwhelmed when applied to populations of more than a dozen or so different speakers. The authors are investigating a solution to the "large population" problem by seeking two completely different kinds of characterizing features. These features are he techniques of Neuro-Linguistic Programming (NLP) and the continuous wavelet transform (CWT). NLP extracts precise neurological, verbal and non-verbal information, and assimilates the information into useful patterns. These patterns are based on specific cues demonstrated by each individual, and provide ways of determining congruency between verbal and non-verbal cues. The primary NLP modalities are characterized through word spotting (or verbal predicates cues, e.g., see, sound, feel, etc.) while the secondary modalities would be characterized through the speech transcription used by the individual. This has the practical effect of reducing the size of the search space, and greatly speeding up the process of identifying an unknown speaker. The wavelet-based line of investigation concentrates on using vowel phonemes and non-verbal cues, such as tempo. The rationale for concentrating on vowels is there are a limited number of vowels phonemes, and at least one of them usually appears in even the shortest of speech segments. Using the fast, CWT algorithm, the details of both the formant frequency and the glottal excitation characteristics can be easily extracted from voice waveforms. The differences in the glottal excitation waveforms as well as the formant frequency are evident in the CWT output. More significantly, the CWT reveals significant detail of the glottal excitation

  6. Speaker recognition through NLP and CWT modeling.

    Energy Technology Data Exchange (ETDEWEB)

    Brown-VanHoozer, A.; Kercel, S. W.; Tucker, R. W.

    1999-06-23

    The objective of this research is to develop a system capable of identifying speakers on wiretaps from a large database (>500 speakers) with a short search time duration (<30 seconds), and with better than 90% accuracy. Much previous research in speaker recognition has led to algorithms that produced encouraging preliminary results, but were overwhelmed when applied to populations of more than a dozen or so different speakers. The authors are investigating a solution to the ''huge population'' problem by seeking two completely different kinds of characterizing features. These features are extracted using the techniques of Neuro-Linguistic Programming (NLP) and the continuous wavelet transform (CWT). NLP extracts precise neurological, verbal and non-verbal information, and assimilates the information into useful patterns. These patterns are based on specific cues demonstrated by each individual, and provide ways of determining congruency between verbal and non-verbal cues. The primary NLP modalities are characterized through word spotting (or verbal predicates cues, e.g., see, sound, feel, etc.) while the secondary modalities would be characterized through the speech transcription used by the individual. This has the practical effect of reducing the size of the search space, and greatly speeding up the process of identifying an unknown speaker. The wavelet-based line of investigation concentrates on using vowel phonemes and non-verbal cues, such as tempo. The rationale for concentrating on vowels is there are a limited number of vowels phonemes, and at least one of them usually appears in even the shortest of speech segments. Using the fast, CWT algorithm, the details of both the formant frequency and the glottal excitation characteristics can be easily extracted from voice waveforms. The differences in the glottal excitation waveforms as well as the formant frequency are evident in the CWT output. More significantly, the CWT reveals significant

  7. NLP as a communication strategy tool in libraries

    Science.gov (United States)

    Koulouris, Alexandros; Sakas, Damianos P.; Giannakopoulos, Georgios

    2015-02-01

    The role of communication is a catalyst for the proper function of an organization. This paper focuses on libraries, where the communication is crucial for their success. In our opinion, libraries in Greece are suffering from the lack of communication and marketing strategy. Communication has many forms and manifestations. A key aspect of communication is body language, which has a dominant communication tool the neuro-linguistic programming (NLP). The body language is a system that expresses and transfers messages, thoughts and emotions. More and more organizations in the public sector and companies in the private sector base their success on the communication skills of their personnel. The NLP suggests several methods to obtain excellent relations in the workplace and to develop ideal communication. The NLP theory is mainly based on the development of standards (communication model) that guarantees the expected results. This research was conducted and analyzed in two parts, the qualitative and the quantitative. The findings mainly confirm the need for proper communication within libraries. In the qualitative research, the interviewees were aware of communication issues, although some gaps in that knowledge were observed. Even this slightly lack of knowledge, highlights the need for constant information through educational programs. This is particularly necessary for senior executives of libraries, who should attend relevant seminars and refresh their knowledge on communication related issues.

  8. Cultural neurolinguistics

    OpenAIRE

    Chen, Chuansheng; Xue, Gui; Mei, Leilei; Chen, Chunhui; Dong, Qi

    2009-01-01

    As the only species that evolved to possess a language faculty, humans have been surprisingly generative in creating a diverse array of language systems. These systems vary in phonology, morphology, syntax, and written forms. Before the advent of modern brain-imaging techniques, little was known about how differences across languages are reflected in the brain. This chapter aims to provide an overview of an emerging area of research - cultural neurolinguistics - that examines systematic cross...

  9. Non Linear Programming (NLP) formulation for quantitative modeling of protein signal transduction pathways.

    Science.gov (United States)

    Mitsos, Alexander; Melas, Ioannis N; Morris, Melody K; Saez-Rodriguez, Julio; Lauffenburger, Douglas A; Alexopoulos, Leonidas G

    2012-01-01

    Modeling of signal transduction pathways plays a major role in understanding cells' function and predicting cellular response. Mathematical formalisms based on a logic formalism are relatively simple but can describe how signals propagate from one protein to the next and have led to the construction of models that simulate the cells response to environmental or other perturbations. Constrained fuzzy logic was recently introduced to train models to cell specific data to result in quantitative pathway models of the specific cellular behavior. There are two major issues in this pathway optimization: i) excessive CPU time requirements and ii) loosely constrained optimization problem due to lack of data with respect to large signaling pathways. Herein, we address both issues: the former by reformulating the pathway optimization as a regular nonlinear optimization problem; and the latter by enhanced algorithms to pre/post-process the signaling network to remove parts that cannot be identified given the experimental conditions. As a case study, we tackle the construction of cell type specific pathways in normal and transformed hepatocytes using medium and large-scale functional phosphoproteomic datasets. The proposed Non Linear Programming (NLP) formulation allows for fast optimization of signaling topologies by combining the versatile nature of logic modeling with state of the art optimization algorithms.

  10. Non Linear Programming (NLP formulation for quantitative modeling of protein signal transduction pathways.

    Directory of Open Access Journals (Sweden)

    Alexander Mitsos

    Full Text Available Modeling of signal transduction pathways plays a major role in understanding cells' function and predicting cellular response. Mathematical formalisms based on a logic formalism are relatively simple but can describe how signals propagate from one protein to the next and have led to the construction of models that simulate the cells response to environmental or other perturbations. Constrained fuzzy logic was recently introduced to train models to cell specific data to result in quantitative pathway models of the specific cellular behavior. There are two major issues in this pathway optimization: i excessive CPU time requirements and ii loosely constrained optimization problem due to lack of data with respect to large signaling pathways. Herein, we address both issues: the former by reformulating the pathway optimization as a regular nonlinear optimization problem; and the latter by enhanced algorithms to pre/post-process the signaling network to remove parts that cannot be identified given the experimental conditions. As a case study, we tackle the construction of cell type specific pathways in normal and transformed hepatocytes using medium and large-scale functional phosphoproteomic datasets. The proposed Non Linear Programming (NLP formulation allows for fast optimization of signaling topologies by combining the versatile nature of logic modeling with state of the art optimization algorithms.

  11. Neuro-Linguistic Programming: Improving Rapport between Track/Cross Country Coaches and Significant Others

    Science.gov (United States)

    Helm, David Jay

    2017-01-01

    This study examines the background information and the components of N.L.P., being eye movements, use of predicates, and posturing, as they apply to improving rapport and empathy between track/cross country coaches and their significant others in the arena of competition to help alleviate the inherent stressors.

  12. Neurolinguistic Applications for the Remediation of Reading Problems.

    Science.gov (United States)

    Arnold, Diane G.; Swaby, Barbara

    1984-01-01

    Notes that neurolinguistic programing, recently introduced in education, helps teachers analyze and overcome barriers to student achievement in reading. Presents applications and implications of the concept. (FL)

  13. Cultural neurolinguistics.

    Science.gov (United States)

    Chen, Chuansheng; Xue, Gui; Mei, Leilei; Chen, Chunhui; Dong, Qi

    2009-01-01

    As the only species that evolved to possess a language faculty, humans have been surprisingly generative in creating a diverse array of language systems. These systems vary in phonology, morphology, syntax, and written forms. Before the advent of modern brain-imaging techniques, little was known about how differences across languages are reflected in the brain. This chapter aims to provide an overview of an emerging area of research - cultural neurolinguistics - that examines systematic cross-cultural/crosslinguistic variations in the neural networks of languages. We first briefly describe general brain networks for written and spoken languages. We then discuss language-specific brain regions by highlighting differences in neural bases of different scripts (logographic vs. alphabetic scripts), orthographies (transparent vs. nontransparent orthographies), and tonality (tonal vs. atonal languages). We also discuss neural basis of second language and the role of native language experience in second-language acquisition. In the last section, we outline a general model that integrates culture and neural bases of language and discuss future directions of research in this area.

  14. Analisis Korelasi Antara Respon Mahasiswa Terhadap Pembelajaran Berbasis Neuro Linguistics Programming (Nlp) Tipe Reframing Dengan Motivasi Belajar Matematika Mahasiswa Semester VII Iain Syekh Nurjati Cirebon

    OpenAIRE

    sudjana, ade; Akbar, Reza Oktiana

    2014-01-01

    A fun learning is one of ways to increase students' learning motivation. Generally,students tend not to have learning motivation, because they do not understand delivered material. With a new learning, it will ease lecturers to deliver materials to students. One of ways which can be used in order to understand the materials is with re-framing perception activity based on neuro linguistics programming (NLP) reframing type. The goal of this research is to know the students' response towards lin...

  15. PROPOSAL FOR NEURAL-LINGUISTIC PROGRAMMING (N.L.P. INTHE ADMINISTRATIVE DEVELOPMENT OF LEADERSHIP SPORTS

    Directory of Open Access Journals (Sweden)

    Khalil Samira

    2010-08-01

    Full Text Available Neural-linguistic programming is an organised method to know the human self construction and dealing with it in fixed means and styles so as to decesisively affect the processes of perception, thinking, imaging, ideas,feeling and also in behavior, skills and the human body and mental performance (1 Neural-linguistic programming has a private nature because it is a group of mechanisms and practicaltechniques far from likeliness, so it enters in the circle of application and employment of the human abilities and possibilities. (9 Al Fiky (2001 points out that neural linguistic programming created the favourable environment to help individuals to get rid of their diseased fears and controlling in their negative reactions and thus improving communication with themselves and with others. He shows it took its way into the human life fields because itsways and strategies are used in the sectors of health, education, marketing and administration(2. The modern administration embarks on the human element that represents the most valuable elementsof administration and is the most effective on the productivity and with the increasing the effect of the human element in the efficacy of the administrative organizations, the need increased to consider the management of the human resources as an independent function of administrative functions that cancers the human element and onwhose efficiency, abilities, experience and zeal for work, the administration efficacy depends.

  16. Do HCI and NLP Interact?

    NARCIS (Netherlands)

    Karamanis, N.; Schneider, A.; van der Sluis, Ielka; Schlogl, S.; Doherty, G.; Luz, S.

    2009-01-01

    We examine the relationship between HCI and Natural Language Processing (NLP) by performing a bibliometric analysis and looking at the specific example of BioNLP. We identify opportunities for HCI to fertilise current NLP research and suggest that HCI will benefit from looking at advances in NLP

  17. Neurolinguistics, History of

    NARCIS (Netherlands)

    Eling, P.A.T.M.

    2015-01-01

    The history of neurolinguistics is described, starting with the modern period, beginning in the 1960s. Subsequently, an overview of studies and theories on the effects of brain lesions on language behavior is presented. Up to the nineteenth century, mainly single case descriptions have been

  18. [Aphasia and neurolinguistics].

    Science.gov (United States)

    Gloning, K

    1978-11-10

    General dominance is a basis of human language. Neurolinguistics deal with this phenomenon and with central language disturbances. Collaboration with general linguistics and neuropsychology is necessary. The most important symptoms of aphasia and the problems of classification and of speech therapy are discussed.

  19. Neuro Linguistic Programming

    Directory of Open Access Journals (Sweden)

    Suzana Padežanin

    1996-12-01

    Full Text Available The paper is in fact an introduction to the field known as neuro-linguistic programming or NLP. It describes the origins of thi s method and funda­ mental assumptions about NLP -current perception of reality, establishment of rapport, and  development of our unique potential in order to understand the world. The paper furthermore provides insight into how we use our inner senses for reflection , how language and thought interact, and how we can determine the way other people think. The NLP method simultaneousl y takes into consideration all of the personality signals - bod y a nd speech signals, and visua l pattems. NLP assumes tha t the usual framework of interpretation and criticism needs to be transcended in order for us to be able to see matters ina different light, and thus develop better al ternatives for achieving our original goals. The paper emphasizes the inner processing of information, which is captured by certain NLP diagnostic models, thus providing the starting point for change.

  20. [Neurolinguistic approaches to aphasia].

    Science.gov (United States)

    Bordas, Lluis Barraquer

    2007-09-01

    Aphasias are language pathologies, therefore the acquaintance of its structure is required for proper understanding. Language is a cultural interaction system, logical, set much above common natural. It separates the symbolic function, which establishes the distinction between significant and signification. We establish a neurolinguistic classification of aphasias, refuting improper expressions. We broach the wrongly called "conduction aphasia". We detach the unit of speech act and we distinguish the existence of a joint project that sheds light on all sentences brought forth. The complex texture of the "transcorticalism" qualify is analyzed. Aphasia field and some forms of its unfolding are questions aborded under the light of basic neurolinguistic concepts. We detach the unit of speech act and we distinguish the existence of a common project that sheds light on all sentences brought forth.

  1. An exploratory study of neuro linguistic programming and communication anxiety

    Science.gov (United States)

    Brunner, Lois M.

    1993-12-01

    This thesis is an exploratory study of Neuro-Linguistic Programming (NLP), and its capabilities to provide a technique or a composite technique that will reduce the anxiety associated with making an oral brief or presentation before a group, sometimes referred to as Communication Apprehension. The composite technique comes from NLP and Time Line Therapy, which is an extension to NLP. Student volunteers (17) from a Communications course given by the Administrative Sciences Department were taught this technique. For each volunteer, an informational oral presentation was made and videotaped before the training and another informational oral presentation made and videotaped following the training. The before and after training presentations for each individual volunteer were evaluated against criteria for communications anxiety and analyzed to determine if there was a noticeable reduction of anxiety after the training. Anxiety was reduced in all of the volunteers in this study.

  2. [Dyslexia: neuropsychological and neurolinguistic aspects].

    Science.gov (United States)

    Van Hout, A

    1991-01-01

    A brief review is given of the contribution of neuropsychological diagnostic methods and neurolinguistic diagnostic investigations. Through the analysis of errors, neurolinguistic examinations today make it possible to isolate in dyslexic populations at least three groups with clear-cut characteristics, requiring a distinct remedial approach. Neuropsychological investigations, and in particular their cross-matching with radiological neuro-imaging methods, serve to evidence the specificity of the cerebral organization of dyslexics.

  3. Assessing Question Quality Using NLP

    Science.gov (United States)

    Kopp, Kristopher J.; Johnson, Amy M.; Crossley, Scott A.; McNamara, Danielle S.

    2017-01-01

    An NLP algorithm was developed to assess question quality to inform feedback on questions generated by students within iSTART (an intelligent tutoring system that teaches reading strategies). A corpus of 4575 questions was coded using a four-level taxonomy. NLP indices were calculated for each question and machine learning was used to predict…

  4. Psychotic speech: a neurolinguistic perspective.

    Science.gov (United States)

    Anand, A; Wales, R J

    1994-06-01

    The existence of an aphasia-like language disorder in psychotic speech has been the subject of much debate. This paper argues that a discrete language disorder could be an important cause of the disturbance seen in psychotic speech. A review is presented of classical clinical descriptions and experimental studies that have explored the similarities between psychotic language impairment and aphasic speech. The paper proposes neurolinguistic tasks which may be used in future studies to elicit subtle language impairments in psychotic speech. The usefulness of a neurolinguistic model for further research in the aetiology and treatment of psychosis is discussed.

  5. GENERAL ASPECTS OF NLP IN TEACHING LANGUAGES

    Directory of Open Access Journals (Sweden)

    Clementina Niţă

    2011-11-01

    Full Text Available This article is focus on NLP as a tool helping to improve personal excellence in teaching languages. NLP states that learning begins in the students’ frame of reference and thus, it is important for teachers to increase their interpersonal skills and ability to recognize it. A map of how language operates is drawn by the Meta Model - a tool for a fuller understanding of what people say -, which deals with the concepts of surface structure and deep structure. The meta programs deal with deletions, distortions and generalisations which appear in language during communication. Establish rapport is a helpful method to create favourable teaching atmosphere and humanising teaching is a way to improve students’ performance.

  6. Using the Natural Language Paradigm (NLP) to Increase Vocalizations of Older Adults with Cognitive Impairments

    Science.gov (United States)

    LeBlanc, Linda A.; Geiger, Kaneen B.; Sautter, Rachael A.; Sidener, Tina M.

    2007-01-01

    The Natural Language Paradigm (NLP) has proven effective in increasing spontaneous verbalizations for children with autism. This study investigated the use of NLP with older adults with cognitive impairments served at a leisure-based adult day program for seniors. Three individuals with limited spontaneous use of functional language participated…

  7. Neurolinguistics Programming: Method or Myth?

    Science.gov (United States)

    Gumm, W. B.; And Others

    1982-01-01

    The preferred modality by which 50 right-handed female college students encoded experience was assessed by recordings of conjugate eye movements, content analysis of the subject's verbal report, and the subject's self-report. Kappa analyses failed to reveal any agreement of the three assessment methods. (Author)

  8. The Neurolinguistics of Second Language Learning.

    Science.gov (United States)

    Cohen, Andrew D., Ed.

    These proceedings are a collection of papers by researchers in neurology, bilingualism, linguistics, and the neurolinguistics of bilingualism. Topics are addressed using neurolinguistic data for second language learning, learning models for second language acquisition, and implications for teaching and research. Summaries of the following papers…

  9. Overexpression of the Maize ZmNLP6 and ZmNLP8 Can Complement the Arabidopsis Nitrate Regulatory Mutant nlp7 by Restoring Nitrate Signaling and Assimilation

    OpenAIRE

    Cao, Huairong; Qi, Shengdong; Sun, Mengwei; Li, Zehui; Yang, Yi; Crawford, Nigel M.; Wang, Yong

    2017-01-01

    Nitrate is a key nutrient that affects maize growth and yield, and much has yet to be learned about nitrate regulatory genes and mechanisms in maize. Here, we identified nine ZmNLP genes in maize and analyzed the functions of two ZmNLP members in nitrate signaling. qPCR results revealed a broad pattern of expression for ZmNLP genes in different stages and organs with the highest levels of transcript expression of ZmNLP6 and ZmNLP8. When ZmNLP6 and ZmNLP8 were overexpressed in the Arabidopsis ...

  10. An NLP-Based Programme for Developing EFL Student-Teachers ...

    African Journals Online (AJOL)

    ... using motivational language. Based on these findings, it was recommended that direct and explicit teaching of motivational language by using influential hypnotic language patterns should be integrated into EFL pre-service teacher training curricula. Keywords: Motivational language, Neuro-linguistic Programming, Milton ...

  11. Hierarchical semantic structures for medical NLP.

    Science.gov (United States)

    Taira, Ricky K; Arnold, Corey W

    2013-01-01

    We present a framework for building a medical natural language processing (NLP) system capable of deep understanding of clinical text reports. The framework helps developers understand how various NLP-related efforts and knowledge sources can be integrated. The aspects considered include: 1) computational issues dealing with defining layers of intermediate semantic structures to reduce the dimensionality of the NLP problem; 2) algorithmic issues in which we survey the NLP literature and discuss state-of-the-art procedures used to map between various levels of the hierarchy; and 3) implementation issues to software developers with available resources. The objective of this poster is to educate readers to the various levels of semantic representation (e.g., word level concepts, ontological concepts, logical relations, logical frames, discourse structures, etc.). The poster presents an architecture for which diverse efforts and resources in medical NLP can be integrated in a principled way.

  12. Computer Assisted Reading in German as a Foreign Language, Developing and Testing an NLP-Based Application

    Science.gov (United States)

    Wood, Peter

    2011-01-01

    "QuickAssist," the program presented in this paper, uses natural language processing (NLP) technologies. It places a range of NLP tools at the disposal of learners, intended to enable them to independently read and comprehend a German text of their choice while they extend their vocabulary, learn about different uses of particular words,…

  13. VnCoreNLP: A Vietnamese Natural Language Processing Toolkit

    OpenAIRE

    Vu, Thanh; Nguyen, Dat Quoc; Nguyen, Dai Quoc; Dras, Mark; Johnson, Mark

    2018-01-01

    We present an easy-to-use and fast toolkit, namely VnCoreNLP---a Java NLP annotation pipeline for Vietnamese. Our VnCoreNLP supports key natural language processing (NLP) tasks including word segmentation, part-of-speech (POS) tagging, named entity recognition (NER) and dependency parsing, and obtains state-of-the-art (SOTA) results for these tasks. We release VnCoreNLP to provide rich linguistic annotations to facilitate research work on Vietnamese NLP. Our VnCoreNLP is open-source under GPL...

  14. Sales Training for Army Recruiter Success: Modeling the Sales Strategies and Skills of Excellent Recruiters

    Science.gov (United States)

    1987-11-01

    Modeling ’Expert knowledge,, Neurolinguistics Knowledge engineering; Recruiting Sales, &’ Sales cycle Sales skills Sales strategies 20...strategies used by excellent Army recruiters. Neurolinguistic programming (NLP) was used as the protocol for modeling performance and acquiring

  15. A theory of neurolinguistic development.

    Science.gov (United States)

    Locke, J L

    1997-06-15

    This article offers a developmental theory of language and the neural systems that lead to and subserve linguistic capabilities. Early perceptual experience and discontinuities in linguistic development suggest that language develops in four phases that occur in a fixed, interdependent sequence. In each phase of language, a unique ontogenetic function is accomplished. These functions have proprietary neural systems that vary in their degree of specialization. Of particular interest is an analytical mechanism that is responsible for linguistic grammar. This mechanism is time-locked and can only be turned on in the third phase. Confirming evidence is provided by children who are delayed in the second phase of the language learning process. These children store insufficient lexical material to activate their analytic mechanism. Inactivation behaves like damage, shifting language functions to homologous mechanisms in the nondominant hemisphere, thereby increasing functional and anatomical symmetry across the hemispheres. This atypical assembly of neurolinguistic resources produces functional but imperfect command of spoken language and may complicate learning of written language. The theory thus offers a different role for genetics and early experience, and a different interpretation of neuroanatomic findings, from those entertained in most other proposals on developmental language disorders.

  16. Launch flexibility using NLP guidance and remote wind sensing

    Science.gov (United States)

    Cramer, Evin J.; Bradt, Jerre E.; Hardtla, John W.

    1990-01-01

    This paper examines the use of lidar wind measurements in the implementation of a guidance strategy for a nonlinear programming (NLP) launch guidance algorithm. The NLP algorithm uses B-spline command function representation for flexibility in the design of the guidance steering commands. Using this algorithm, the guidance system solves a two-point boundary value problem at each guidance update. The specification of different boundary value problems at each guidance update provides flexibility that can be used in the design of the guidance strategy. The algorithm can use lidar wind measurements for on pad guidance retargeting and for load limiting guidance steering commands. Examples presented in the paper use simulated wind updates to correct wind induced final orbit errors and to adjust the guidance steering commands to limit the product of the dynamic pressure and angle-of-attack for launch vehicle load alleviation.

  17. Current Trends in Neurolinguistic Studies of Bilingualism.

    Science.gov (United States)

    Kraetschmer, Kurt

    1986-01-01

    A review of current research in bilingualism reveals much attention being given to the role of the brain's right hemisphere in linguistic production. It is proposed that application of findings in second-language learning research and applied linguistics would give experimental support to the existing neurolinguistic theories. (MSE)

  18. Characterization of necrosis-inducing NLP proteins in Phytophthora capsici.

    Science.gov (United States)

    Feng, Bao-Zhen; Zhu, Xiao-Ping; Fu, Li; Lv, Rong-Fei; Storey, Dylan; Tooley, Paul; Zhang, Xiu-Guo

    2014-05-08

    Effector proteins function not only as toxins to induce plant cell death, but also enable pathogens to suppress or evade plant defense responses. NLP-like proteins are considered to be effector proteins, and they have been isolated from bacteria, fungi, and oomycete plant pathogens. There is increasing evidence that NLPs have the ability to induce cell death and ethylene accumulation in plants. We evaluated the expression patterns of 11 targeted PcNLP genes by qRT-PCR at different time points after infection by P. capsici. Several PcNLP genes were strongly expressed at the early stages in the infection process, but the expression of other PcNLP genes gradually increased to a maximum at late stages of infection. The genes PcNLP2, PcNLP6 and PcNLP14 showed the highest expression levels during infection by P. capsici. The necrosis-inducing activity of all targeted PcNLP genes was evaluated using heterologous expression by PVX agroinfection of Capsicum annuum and Nicotiana benthamiana and by Western blot analysis. The members of the PcNLP family can induce chlorosis or necrosis during infection of pepper and tobacco leaves, but the chlorotic or necrotic response caused by PcNLP genes was stronger in pepper leaves than in tobacco leaves. Moreover, PcNLP2, PcNLP6, and PcNLP14 caused the largest chlorotic or necrotic areas in both host plants, indicating that these three genes contribute to strong virulence during infection by P. capsici. This was confirmed through functional evaluation of their silenced transformants. In addition, we further verified that four conserved residues are putatively active sites in PcNLP1 by site-directed mutagenesis. Each targeted PcNLP gene affects cells or tissues differently depending upon the stage of infection. Most PcNLP genes could trigger necrotic or chlorotic responses when expressed in the host C. annuum and the non-host N. benthamiana. Individual PcNLP genes have different phytotoxic effects, and PcNLP2, PcNLP6, and PcNLP14 may

  19. An Implementation Guide for the Experimental Application of Suggestive-Accelerative Learning and Teaching to the Coast Guard Training Environment.

    Science.gov (United States)

    1986-06-01

    ht Brain, San Francisco: W.H. Freeman and Company, 1981. Stevens, John 0., " Neurolinguistic Programming (NLP) and Gestalt," The Journal of Gestalt...Stevens, John 0., - Neurolinguistic Programming (NLP) and Gestalt," The Journal of Gestalt, vol. 1, no.2. pp. 84-87, 1978. Tart, Charles T., ed., Ajtgr3

  20. Expletives: neurolinguistic and neurobehavioral perspectives on swearing.

    Science.gov (United States)

    Van Lancker, D; Cummings, J L

    1999-12-01

    Severe aphasia, adult left hemispherectomy, Gilles de la Tourette syndrome (GTS), and other neurological disorders have in common an increased use of swearwords. There are shared linguistic features in common across these language behaviors, as well as important differences. We explore the nature of swearing in normal human communication, and then compare the clinical presentations of selectively preserved, impaired and augmented swearing. These neurolinguistic observations, considered along with related neuroanatomical and neurochemical information, provide the basis for considering the neurobiological foundation of various types of swearing behaviors.

  1. Social anxiety and training in neurolinguistic programming.

    Science.gov (United States)

    Konefal, J; Duncan, R C

    1998-12-01

    The Liebowitz Social Phobia Scale measured the effect of training on social anxiety responses of 28 adults prior to and following a 21-day residential training, and at 6 mo. follow-up. Significant reductions posttraining and at follow-up were evident in the mean self-reported global scale scores on fear and avoidance behavior in social situations. The item scores, aggregated to reflect the situational domains of formal and informal speaking, being observed by others, and assertion, showed significant and continuing reduction from posttraining through follow-up. These findings are consistent with the hypothesis that this training may be associated with reduced responses to social anxiety, but as there was no formal control group, pretest scores from another study were used. Interpretation is limited.

  2. Estimating relative risks for common outcome using PROC NLP.

    Science.gov (United States)

    Yu, Binbing; Wang, Zhuoqiao

    2008-05-01

    In cross-sectional or cohort studies with binary outcomes, it is biologically interpretable and of interest to estimate the relative risk or prevalence ratio, especially when the response rates are not rare. Several methods have been used to estimate the relative risk, among which the log-binomial models yield the maximum likelihood estimate (MLE) of the parameters. Because of restrictions on the parameter space, the log-binomial models often run into convergence problems. Some remedies, e.g., the Poisson and Cox regressions, have been proposed. However, these methods may give out-of-bound predicted response probabilities. In this paper, a new computation method using the SAS Nonlinear Programming (NLP) procedure is proposed to find the MLEs. The proposed NLP method was compared to the COPY method, a modified method to fit the log-binomial model. Issues in the implementation are discussed. For illustration, both methods were applied to data on the prevalence of microalbuminuria (micro-protein leakage into urine) for kidney disease patients from the Diabetes Control and Complications Trial. The sample SAS macro for calculating relative risk is provided in the appendix.

  3. Neurolinguistics Aspects of Second Language Acquisition

    Directory of Open Access Journals (Sweden)

    Laleh Fakhraee Faruji

    2011-12-01

    Full Text Available   Fundamental breakthroughs in the neurosciences, combined with technical innovations for measuring brain activity, are shedding new light on the neural basis of second language (L2
    processing, and on its relationship to native language processing (L1 (Perani & Abutalebi, 2005.  Over the past two decades, a large body of neuroimaging studies has been devoted to the study of the neural organization of language (De´monet, Thierry, & Cardebat, 2005; Indefrey & Levelt, 2004; Price, 2000 as cited in Abutalebi, 2008. The value that functional neuroimaging adds to language research is to improve the perspective on the distributed anatomy of language. Thus, it can be used with considerable precision to identify the neural networks underlying the different domains of language processing. In this paper some main issues related to neurolinguistics and second language acquisition with a focus on bilingualism will be discussed.

  4. RNAi-mediated disruption of neuropeptide genes, nlp-3 and nlp-12, cause multiple behavioral defects in Meloidogyne incognita.

    Science.gov (United States)

    Dash, Manoranjan; Dutta, Tushar K; Phani, Victor; Papolu, Pradeep K; Shivakumara, Tagginahalli N; Rao, Uma

    2017-08-26

    Owing to the current deficiencies in chemical control options and unavailability of novel management strategies, root-knot nematode (M. incognita) infections remain widespread with significant socio-economic impacts. Helminth nervous systems are peptide-rich and appear to be putative drug targets that could be exploited by antihelmintic chemotherapy. Herein, to characterize the novel peptidergic neurotransmitters, in silico mining of M. incognita genomic and transciptomic datasets revealed the presence of 16 neuropeptide-like protein (nlp) genes with structural hallmarks of neuropeptide preproproteins; among which 13 nlps were PCR-amplified and sequenced. Two key nlp genes (Mi-nlp-3 and Mi-nlp-12) were localized to the basal bulb and tail region of nematode body via in situ hybridization assay. Mi-nlp-3 and Mi-nlp-12 were greatly expressed (in qRT-PCR assay) in the pre-parasitic juveniles and adult females, suggesting the association of these genes in host recognition, development and reproduction of M. incognita. In vitro knockdown of Mi-nlp-3 and Mi-nlp-12 via RNAi demonstrated the significant reduction in attraction and penetration of M. incognita in tomato root in Pluronic gel medium. A pronounced perturbation in development and reproduction of NLP-silenced worms was also documented in adzuki beans in CYG growth pouches. The deleterious phenotypes obtained due to NLP knockdown suggests that transgenic plants engineered to express RNA constructs targeting nlp genes may emerge as an environmentally viable option to manage nematode problems in crop plants. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. [Structuralization of digestive endoscopy report based on NLP].

    Science.gov (United States)

    Kong, Xiao-feng; Li, Ying; Li, Hao-min; Lu, Xu-dong

    2008-09-01

    This paper presents a method based on NLP to realize structuralization of digestive endoscopy reports. The method is taking advantage of existing NLP's processing technologies and introducing minimal standard terminology (MST) to transform a narrative gastroscopy report into the structuralization report based on MST, whose accuracy rate is 92.3%.

  6. Aurora B interaction of centrosomal Nlp regulates cytokinesis.

    Science.gov (United States)

    Yan, Jie; Jin, Shunqian; Li, Jia; Zhan, Qimin

    2010-12-17

    Cytokinesis is a fundamental cellular process, which ensures equal abscission and fosters diploid progenies. Aberrant cytokinesis may result in genomic instability and cell transformation. However, the underlying regulatory machinery of cytokinesis is largely undefined. Here, we demonstrate that Nlp (Ninein-like protein), a recently identified BRCA1-associated centrosomal protein that is required for centrosomes maturation at interphase and spindle formation in mitosis, also contributes to the accomplishment of cytokinesis. Through immunofluorescent analysis, Nlp is found to localize at midbody during cytokinesis. Depletion of endogenous Nlp triggers aborted division and subsequently leads to multinucleated phenotypes. Nlp can be recruited by Aurora B to the midbody apparatus via their physical association at the late stage of mitosis. Disruption of their interaction induces aborted cytokinesis. Importantly, Nlp is characterized as a novel substrate of Aurora B and can be phosphorylated by Aurora B. The specific phosphorylation sites are mapped at Ser-185, Ser-448, and Ser-585. The phosphorylation at Ser-448 and Ser-585 is likely required for Nlp association with Aurora B and localization at midbody. Meanwhile, the phosphorylation at Ser-185 is vital to Nlp protein stability. Disruptions of these phosphorylation sites abolish cytokinesis and lead to chromosomal instability. Collectively, these observations demonstrate that regulation of Nlp by Aurora B is critical for the completion of cytokinesis, providing novel insights into understanding the machinery of cell cycle progression.

  7. Aurora B Interaction of Centrosomal Nlp Regulates Cytokinesis*

    Science.gov (United States)

    Yan, Jie; Jin, Shunqian; Li, Jia; Zhan, Qimin

    2010-01-01

    Cytokinesis is a fundamental cellular process, which ensures equal abscission and fosters diploid progenies. Aberrant cytokinesis may result in genomic instability and cell transformation. However, the underlying regulatory machinery of cytokinesis is largely undefined. Here, we demonstrate that Nlp (Ninein-like protein), a recently identified BRCA1-associated centrosomal protein that is required for centrosomes maturation at interphase and spindle formation in mitosis, also contributes to the accomplishment of cytokinesis. Through immunofluorescent analysis, Nlp is found to localize at midbody during cytokinesis. Depletion of endogenous Nlp triggers aborted division and subsequently leads to multinucleated phenotypes. Nlp can be recruited by Aurora B to the midbody apparatus via their physical association at the late stage of mitosis. Disruption of their interaction induces aborted cytokinesis. Importantly, Nlp is characterized as a novel substrate of Aurora B and can be phosphorylated by Aurora B. The specific phosphorylation sites are mapped at Ser-185, Ser-448, and Ser-585. The phosphorylation at Ser-448 and Ser-585 is likely required for Nlp association with Aurora B and localization at midbody. Meanwhile, the phosphorylation at Ser-185 is vital to Nlp protein stability. Disruptions of these phosphorylation sites abolish cytokinesis and lead to chromosomal instability. Collectively, these observations demonstrate that regulation of Nlp by Aurora B is critical for the completion of cytokinesis, providing novel insights into understanding the machinery of cell cycle progression. PMID:20864540

  8. Syntactic dependency parsers for biomedical-NLP.

    Science.gov (United States)

    Cohen, Raphael; Elhadad, Michael

    2012-01-01

    Syntactic parsers have made a leap in accuracy and speed in recent years. The high order structural information provided by dependency parsers is useful for a variety of NLP applications. We present a biomedical model for the EasyFirst parser, a fast and accurate parser for creating Stanford Dependencies. We evaluate the models trained in the biomedical domains of EasyFirst and Clear-Parser in a number of task oriented metrics. Both parsers provide stat of the art speed and accuracy in the Genia of over 89%. We show that Clear-Parser excels at tasks relating to negation identification while EasyFirst excels at tasks relating to Named Entities and is more robust to changes in domain.

  9. Open Source Clinical NLP – More than Any Single System

    Science.gov (United States)

    Masanz, James; Pakhomov, Serguei V.; Xu, Hua; Wu, Stephen T.; Chute, Christopher G.; Liu, Hongfang

    2014-01-01

    The number of Natural Language Processing (NLP) tools and systems for processing clinical free-text has grown as interest and processing capability have surged. Unfortunately any two systems typically cannot simply interoperate, even when both are built upon a framework designed to facilitate the creation of pluggable components. We present two ongoing activities promoting open source clinical NLP. The Open Health Natural Language Processing (OHNLP) Consortium was originally founded to foster a collaborative community around clinical NLP, releasing UIMA-based open source software. OHNLP’s mission currently includes maintaining a catalog of clinical NLP software and providing interfaces to simplify the interaction of NLP systems. Meanwhile, Apache cTAKES aims to integrate best-of-breed annotators, providing a world-class NLP system for accessing clinical information within free-text. These two activities are complementary. OHNLP promotes open source clinical NLP activities in the research community and Apache cTAKES bridges research to the health information technology (HIT) practice. PMID:25954581

  10. Open Source Clinical NLP - More than Any Single System.

    Science.gov (United States)

    Masanz, James; Pakhomov, Serguei V; Xu, Hua; Wu, Stephen T; Chute, Christopher G; Liu, Hongfang

    2014-01-01

    The number of Natural Language Processing (NLP) tools and systems for processing clinical free-text has grown as interest and processing capability have surged. Unfortunately any two systems typically cannot simply interoperate, even when both are built upon a framework designed to facilitate the creation of pluggable components. We present two ongoing activities promoting open source clinical NLP. The Open Health Natural Language Processing (OHNLP) Consortium was originally founded to foster a collaborative community around clinical NLP, releasing UIMA-based open source software. OHNLP's mission currently includes maintaining a catalog of clinical NLP software and providing interfaces to simplify the interaction of NLP systems. Meanwhile, Apache cTAKES aims to integrate best-of-breed annotators, providing a world-class NLP system for accessing clinical information within free-text. These two activities are complementary. OHNLP promotes open source clinical NLP activities in the research community and Apache cTAKES bridges research to the health information technology (HIT) practice.

  11. Thirty years of research on developmental neurolinguistics.

    Science.gov (United States)

    Locke, J L

    1992-01-01

    A body of medically important work has accumulated in the field of developmental neurolinguistics in the 30 years since Lenneberg set forth a research agenda for that field, consisting of the following: (1) the physiologic specialization or endowment for speech; (2) the genetic origin or natural history of vocalization and speech; (3) the nature of prelinguistic behavior, making possible the detection of any environmental (social) influences; (4) the development of motor-speech organization from birth; and (5) the limiting effects of deficient intelligence, hearing, and environmental stimulation. Subsequent study of these questions has established a genetic, neuroanatomic, and functional basis for such outwardly disparate disorders as dyslexia, stuttering, autism, and delayed language. Studies of emergent motor behavior suggest that babbling may index a state of neural maturation favoring expression of spoken languages. Based on studies of the congenitally deaf, mentally retarded, and other clinical populations it is now considered possible to detect early warning signs of developmental language disorders during the first year of life based on analyses of vocal turn-taking, gesturing, and utterance complexity.

  12. Answer Extraction Towards better Evaluations of NLP Systems

    OpenAIRE

    Schwitter, R; Mollà, D; Fournier, R; Hess, M

    2000-01-01

    We argue that reading comprehension tests are not particularly suited for the evaluation of NLP systems. Reading comprehension tests are specifically designed to evaluate human reading skills, and these require vast amounts of world knowledge and common-sense reasoning capabilities. Experience has shown that this kind of full-fledged question answering (QA) over texts from a wide range of domains is so difficult for machines as to be far beyond the present state of the art of NLP. To advance ...

  13. Parallelization of Neural Network Training for NLP with Hogwild!

    Directory of Open Access Journals (Sweden)

    Deyringer Valentin

    2017-10-01

    Full Text Available Neural Networks are prevalent in todays NLP research. Despite their success for different tasks, training time is relatively long. We use Hogwild! to counteract this phenomenon and show that it is a suitable method to speed up training Neural Networks of different architectures and complexity. For POS tagging and translation we report considerable speedups of training, especially for the latter. We show that Hogwild! can be an important tool for training complex NLP architectures.

  14. Gene expression and pharmacology of nematode NLP-12 neuropeptides.

    Science.gov (United States)

    McVeigh, Paul; Leech, Suzie; Marks, Nikki J; Geary, Timothy G; Maule, Aaron G

    2006-05-31

    This study examines the biology of NLP-12 neuropeptides in Caenorhabditis elegans, and in the parasitic nematodes Ascaris suum and Trichostrongylus colubriformis. DYRPLQFamide (1 nM-10 microM; n > or =6) produced contraction of innervated dorsal and ventral Ascaris body wall muscle preparations (10 microM, 6.8+/-1.9 g; 1 microM, 4.6+/-1.8 g; 0.1 microM, 4.1+/-2.0 g; 10 nM, 3.8+/-2.0 g; n > or =6), and also caused a qualitatively similar, but quantitatively lower contractile response (10 microM, 4.0+/-1.5 g, n=6) on denervated muscle strips. Ovijector muscle displayed no measurable response (10 microM, n=5). nlp-12 cDNAs were characterised from A. suum (As-nlp-12) and T. colubriformis (Tc-nlp-12), both of which show sequence similarity to C. elegans nlp-12, in that they encode multiple copies of -LQFamide peptides. In C. elegans, reverse transcriptase (RT)-PCR analysis showed that nlp-12 was transcribed throughout the life cycle, suggesting that DYRPLQFamide plays a constitutive role in the nervous system of this nematode. Transcription was also identified in both L3 and adult stages of T. colubriformis, in which Tc-nlp-12 is expressed in a single tail neurone. Conversely, As-nlp-12 is expressed in both head and tail tissue of adult female A. suum, suggesting species-specific differences in the transcription pattern of this gene.

  15. Controlling the effect of crowd noisy annotations in NLP Tasks

    OpenAIRE

    Abad, Azad

    2017-01-01

    Natural Language Processing (NLP) is a sub-field of Artificial Intelligence and Linguistics, with the aim of studying problems in the automatic generation and understanding of natural language. It involves identifying and exploiting linguistic rules and variation with code to translate unstructured language data into information with a schema. Empirical methods in NLP employ machine learning techniques to automatically extract linguistic knowledge from big textual data instead of hard-c...

  16. HTP-NLP: A New NLP System for High Throughput Phenotyping.

    Science.gov (United States)

    Schlegel, Daniel R; Crowner, Chris; Lehoullier, Frank; Elkin, Peter L

    2017-01-01

    Secondary use of clinical data for research requires a method to quickly process the data so that researchers can quickly extract cohorts. We present two advances in the High Throughput Phenotyping NLP system which support the aim of truly high throughput processing of clinical data, inspired by a characterization of the linguistic properties of such data. Semantic indexing to store and generalize partially-processed results and the use of compositional expressions for ungrammatical text are discussed, along with a set of initial timing results for the system.

  17. Does Functional Neuroimaging Solve the Questions of Neurolinguistics?

    Science.gov (United States)

    Sidtis, Diana Van Lancker

    2006-01-01

    Neurolinguistic research has been engaged in evaluating models of language using measures from brain structure and function, and/or in investigating brain structure and function with respect to language representation using proposed models of language. While the aphasiological strategy, which classifies aphasias based on performance modality and a…

  18. Language and Cognition: interfaces between Psycholinguistics and Neurolinguistics

    OpenAIRE

    Scherer, Lilian Cristine; Jerônimo, Gislaine Machado; Aquino, Carla de

    2013-01-01

    Presentation of the issue: Language and Cognition: interfaces between Psycholinguistics and Neurolinguistics Apresentação do Dossiê de Linguística: Linguagem e Cognição: interfaces entre Psicolinguística e Neurolinguística

  19. Sign Languages: Contribution to Neurolinguistics from Cross-Modal Research.

    Science.gov (United States)

    Malaia, Evie; Wilbur, Ronnie

    2010-12-01

    Using sign language research as an example, we argue that both the cross-linguistic descriptive approach to data, advocated by Evans and Levinson (2009), as well as abstract ('formal') analyses are necessary steps towards the development of "neurolinguistic primitives" for investigating how human languages are instantiated in the brain.

  20. Dysarthric Bengali speech: a neurolinguistic study.

    Science.gov (United States)

    Chakraborty, N; Roy, T; Hazra, A; Biswas, A; Bhattacharya, K

    2008-01-01

    Dysarthria affects linguistic domains such as respiration, phonation, articulation, resonance and prosody due to upper motor neuron, lower motor neuron, cerebellar or extrapyramidal tract lesions. Although Bengali is one of the major languages globally, dysarthric Bengali speech has not been subjected to neurolinguistic analysis. We attempted such an analysis with the goal of identifying the speech defects in native Bengali speakers in various types of dysarthria encountered in neurological disorders. A cross-sectional observational study was conducted with 66 dysarthric subjects, predominantly middle-aged males, attending the Neuromedicine OPD of a tertiary care teaching hospital in Kolkata. After neurological examination, an instrument comprising commonly used Bengali words and a text block covering all Bengali vowels and consonants were used to carry out perceptual analysis of dysarthric speech. From recorded speech, 24 parameters pertaining to five linguistic domains were assessed. The Kruskal-Wallis analysis of variance, Chi-square test and Fisher's exact test were used for analysis. The dysarthria types were spastic (15 subjects), flaccid (10), mixed (12), hypokinetic (12), hyperkinetic (9) and ataxic (8). Of the 24 parameters assessed, 15 were found to occur in one or more types with a prevalence of at least 25%. Imprecise consonant was the most frequently occurring defect in most dysarthrias. The spectrum of defects in each type was identified. Some parameters were capable of distinguishing between types. This perceptual analysis has defined linguistic defects likely to be encountered in dysarthric Bengali speech in neurological disorders. The speech distortion can be described and distinguished by a limited number of parameters. This may be of importance to the speech therapist and neurologist in planning rehabilitation and further management.

  1. Dysarthric Bengali speech: A neurolinguistic study

    Directory of Open Access Journals (Sweden)

    Chakraborty N

    2008-01-01

    Full Text Available Background and Aims: Dysarthria affects linguistic domains such as respiration, phonation, articulation, resonance and prosody due to upper motor neuron, lower motor neuron, cerebellar or extrapyramidal tract lesions. Although Bengali is one of the major languages globally, dysarthric Bengali speech has not been subjected to neurolinguistic analysis. We attempted such an analysis with the goal of identifying the speech defects in native Bengali speakers in various types of dysarthria encountered in neurological disorders. Settings and Design: A cross-sectional observational study was conducted with 66 dysarthric subjects, predominantly middle-aged males, attending the Neuromedicine OPD of a tertiary care teaching hospital in Kolkata. Materials and Methods: After neurological examination, an instrument comprising commonly used Bengali words and a text block covering all Bengali vowels and consonants were used to carry out perceptual analysis of dysarthric speech. From recorded speech, 24 parameters pertaining to five linguistic domains were assessed. The Kruskal-Wallis analysis of variance, Chi-square test and Fisher′s exact test were used for analysis. Results: The dysarthria types were spastic (15 subjects, flaccid (10, mixed (12, hypokinetic (12, hyperkinetic (9 and ataxic (8. Of the 24 parameters assessed, 15 were found to occur in one or more types with a prevalence of at least 25%. Imprecise consonant was the most frequently occurring defect in most dysarthrias. The spectrum of defects in each type was identified. Some parameters were capable of distinguishing between types. Conclusions: This perceptual analysis has defined linguistic defects likely to be encountered in dysarthric Bengali speech in neurological disorders. The speech distortion can be described and distinguished by a limited number of parameters. This may be of importance to the speech therapist and neurologist in planning rehabilitation and further management.

  2. The neurolinguistic approach to awake surgery reviewed.

    Science.gov (United States)

    De Witte, Elke; Mariën, Peter

    2013-02-01

    Intraoperative direct electrical stimulation (DES) is increasingly used in patients operated on for tumours in critical language areas. Although a positive impact of DES on postoperative linguistic outcome is generally advocated, the literature is only scantily documented with information about the linguistic methods applied in awake surgery. This article critically reviews the neurolinguistic procedures currently used in awake studies. Based on an extensive review of the literature, an overview is given of the language mapping techniques applied in brain tumour surgery. Studies investigating linguistic testing and outcome in awake surgery were analysed. Information about the timing of the assessment(s), the linguistic tasks, the linguistic stimuli and the indication for awake surgery was also discussed. Intraoperative DES remains the 'gold standard' for language mapping, but pre- and postoperative non-invasive mapping methods are important adjuncts. In the pre- and postoperative phase, standardised linguistic test batteries are generally used to assess language function. In the intraoperative phase, only naming and number counting are commonly applied. Most often no detailed information about the linguistic stimuli is provided and no standardised protocols measuring different linguistic levels have been described. Awake surgery with DES is a useful tool for preserving linguistic functions in patients undergoing surgery in critical brain regions. However, no studies exist that apply a well-balanced and standardised linguistic protocol to reliably identify the critical language zones. The availability of a standardised linguistic protocol might substantially increase intraoperative comfort and might improve outcome and quality of life. Copyright © 2012 Elsevier B.V. All rights reserved.

  3. IMPROVING WRITING DESCRIPTIVE TEXT BY USING NLP STRATEGY AT VIII GRADE OF SMPN 11 DURI

    Directory of Open Access Journals (Sweden)

    Dahler Dahler

    2017-07-01

    Full Text Available This research is based on the problem faced by the students such as: difficulty inunderstanding the generic structures of descriptive text and the difficulties in developingparagraph. The purpose of this research was to improve the students’ writing skill by usingNeuro Linguistics Programming (NLP strategy at VIII grade of SMPN 11 Mandau Duri. Theresearch design was Classroom Action Research (CAR consisted of two cycles. The datawere collected by using test, field note, observation sheet, and interview. Then, the datacollected were analyzed by using scoring rubric of writing descriptive text. The result showedthat students’ ability in writing descriptive text could be improved. It could be seen frombased score of students writing skill was 38 (failed improve to 51 (failed in cycle 1 to 70(Pass in cycle II. It was caused by some factors, those were the teacher gave motivation,created enjoyfull experience, comfortable class and used various media. In conclusion, theuse of NLP strategy has many beneficial.Keywords:Writing skill, Descriptive Text and NLP strategy.

  4. Two Languages in One Brain: Recent Work in Neurolinguistics and Its Implications for Second Language Learning.

    Science.gov (United States)

    Soudek, Lev I.

    1981-01-01

    Briefly outlines progress in neurolinguistics including Broca's aphasia, multilingual aphasiacs, lateralization, and localization as possible explanations for problem of adult foreign language accent. (BK)

  5. Increased expression of Nlp, a potential oncogene in ovarian cancer, and its implication in carcinogenesis.

    Science.gov (United States)

    Qu, Danni; Qu, Hongyan; Fu, Ming; Zhao, Xuelian; Liu, Rong; Sui, Lihua; Zhan, Qimin

    2008-08-01

    Nlp (Ninein-like protein), a novel centrosome protein involved in microtubule nucleation, has been studied extensively in our laboratory, and its overexpression has been found in some human tumors. To understand the role of Nlp in human ovarian cancer development, we studied the correlation of Nlp expression with clinicopathological parameters and survival in epithelial ovarian cancer, and the impact of Nlp overexpression on ovarian cancer cells. Nlp expression in normal, borderline, benign and malignant epithelial ovarian tissues was examined by immunohistochemistry. The correlation between Nlp expression and tumor grade, FIGO stage and histological type was also evaluated. Survival was calculated using Kaplan-Meier estimates. Cell proliferation and apoptosis were assayed after stable transfection of pEGFP-C3-Nlp or empty vector in human ovarian cancer cell line SKOV3. Nlp was positive in 1 of 10 (10%) normal ovarian tissues, 5 of 34 (14.7%) benign tumors, 9 of 26 (34.6%) borderline tumors and 73 of 131 (56.0%) ovarian tumors. Nlp immunoreactivity intensity significantly correlated with tumor grade, but not with FIGO stage or histological type. Kaplan-Meier curves showed that Nlp overexpression was marginally associated with decreased overall survival. Overexpression of Nlp enhanced proliferation and inhibited apoptosis induced by paclitaxel in the SKOV3 cell line. Overexpression of Nlp in ovarian tumors raises the possibility that Nlp may play a role in ovarian carcinogenesis.

  6. A cloud-based approach to medical NLP.

    Science.gov (United States)

    Chard, Kyle; Russell, Michael; Lussier, Yves A; Mendonça, Eneida A; Silverstein, Jonathan C

    2011-01-01

    Natural Language Processing (NLP) enables access to deep content embedded in medical texts. To date, NLP has not fulfilled its promise of enabling robust clinical encoding, clinical use, quality improvement, and research. We submit that this is in part due to poor accessibility, scalability, and flexibility of NLP systems. We describe here an approach and system which leverages cloud-based approaches such as virtual machines and Representational State Transfer (REST) to extract, process, synthesize, mine, compare/contrast, explore, and manage medical text data in a flexibly secure and scalable architecture. Available architectures in which our Smntx (pronounced as semantics) system can be deployed include: virtual machines in a HIPAA-protected hospital environment, brought up to run analysis over bulk data and destroyed in a local cloud; a commercial cloud for a large complex multi-institutional trial; and within other architectures such as caGrid, i2b2, or NHIN.

  7. BRCA1 interaction of centrosomal protein Nlp is required for successful mitotic progression.

    Science.gov (United States)

    Jin, Shunqian; Gao, Hua; Mazzacurati, Lucia; Wang, Yang; Fan, Wenhong; Chen, Qiang; Yu, Wei; Wang, Mingrong; Zhu, Xueliang; Zhang, Chuanmao; Zhan, Qimin

    2009-08-21

    Breast cancer susceptibility gene BRCA1 is implicated in the control of mitotic progression, although the underlying mechanism(s) remains to be further defined. Deficiency of BRCA1 function leads to disrupted mitotic machinery and genomic instability. Here, we show that BRCA1 physically interacts and colocalizes with Nlp, an important molecule involved in centrosome maturation and spindle formation. Interestingly, Nlp centrosomal localization and its protein stability are regulated by normal cellular BRCA1 function because cells containing BRCA1 mutations or silenced for endogenous BRCA1 exhibit disrupted Nlp colocalization to centrosomes and enhanced Nlp degradation. Its is likely that the BRCA1 regulation of Nlp stability involves Plk1 suppression. Inhibition of endogenous Nlp via the small interfering RNA approach results in aberrant spindle formation, aborted chromosomal segregation, and aneuploidy, which mimic the phenotypes of disrupted BRCA1. Thus, BRCA1 interaction of Nlp might be required for the successful mitotic progression, and abnormalities of Nlp lead to genomic instability.

  8. Comparison of Caenorhabditis elegans NLP peptides with arthropod neuropeptides.

    Science.gov (United States)

    Husson, Steven J; Lindemans, Marleen; Janssen, Tom; Schoofs, Liliane

    2009-04-01

    Neuropeptides are small messenger molecules that can be found in all metazoans, where they govern a diverse array of physiological processes. Because neuropeptides seem to be conserved among pest species, selected peptides can be considered as attractive targets for drug discovery. Much can be learned from the model system Caenorhabditis elegans because of the availability of a sequenced genome and state-of-the-art postgenomic technologies that enable characterization of endogenous peptides derived from neuropeptide-like protein (NLP) precursors. Here, we provide an overview of the NLP peptide family in C. elegans and discuss their resemblance with arthropod neuropeptides and their relevance for anthelmintic discovery.

  9. Usability Evaluation of NLP-PIER: A Clinical Document Search Engine for Researchers.

    Science.gov (United States)

    Hultman, Gretchen; McEwan, Reed; Pakhomov, Serguei; Lindemann, Elizabeth; Skube, Steven; Melton, Genevieve B

    2017-01-01

    NLP-PIER (Natural Language Processing - Patient Information Extraction for Research) is a self-service platform with a search engine for clinical researchers to perform natural language processing (NLP) queries using clinical notes. We conducted user-centered testing of NLP-PIER's usability to inform future design decisions. Quantitative and qualitative data were analyzed. Our findings will be used to improve the usability of NLP-PIER.

  10. De la linguistique a la neurolinguistique: 1930-1976 (From Linguistics to Neurolinguistics: 1930-1976)

    Science.gov (United States)

    Dubois, Jean

    1977-01-01

    A survey of the historical developments of linguistic theories relating to aphasia. Some topics covered are: the breakdown of language as opposed to acquisition of language; functional structuralism basic to neurolinguistics; analysis of language disorders; neurolinguistics--models and typology; aphasia and agraphia. (Text is in French.) (AMH)

  11. NLP and the Humanities: The Revival of an Old Liaison

    NARCIS (Netherlands)

    de Jong, Franciska M.G.

    This paper presents an overview of some emerging trends in the application of NLP in the domain of the so-called Digital Humanities and discusses the role and nature of metadata, the annotation layer that is so characteristic of documents that play a role in the scholarly practises of the

  12. Overexpression of centrosomal protein Nlp confers breast carcinoma resistance to paclitaxel.

    Science.gov (United States)

    Zhao, Weihong; Song, Yongmei; Xu, Binghe; Zhan, Qimin

    2012-02-01

    Nlp (ninein-like protein), an important molecule involved in centrosome maturation and spindle formation, plays an important role in tumorigenesis and its abnormal expression was recently observed in human breast and lung cancers. In this study, the correlation between overexpression of Nlp and paclitaxel chemosensitivity was investigated to explore the mechanisms of resistance to paclitaxel and to understand the effect of Nlp upon apoptosis induced by chemotherapeutic agents. Nlp expression vector was stably transfected into breast cancer MCF-7 cells. With Nlp overexpression, the survival rates, cell cycle distributions and apoptosis were analyzed in transfected MCF-7 cells by MTT test and FCM approach. The immunofluorescent assay was employed to detect the changes of microtubule after paclitaxel treatment. Immunoblotting analysis was used to examine expression of centrosomal proteins and apoptosis associated proteins. Subsequently, Nlp expression was retrospectively examined with 55 breast cancer samples derived from paclitaxel treated patients. Interestingly, the survival rates of MCF-7 cells with Nlp overexpressing were higher than that of control after paclitaxel treatment. Nlp overexpression promoted G2-M arrest and attenuated apoptosis induced by paclitaxel, which was coupled with elevated Bcl-2 protein. Nlp expression significantly lessened the microtubule polymerization and bundling elicited by paclitaxel attributing to alteration on the structure or dynamics of β-tubulin but not on its expression. The breast cancer patients with high expression of Nlp were likely resistant to the treatment of paclitaxel, as the response rate in Nlp negative patients was 62.5%, whereas was 58.3 and 15.8% in Nlp (+) and Nlp (++) patients respectively (p = 0.015). Nlp expression was positive correlated with those of Plk1 and PCNA. These findings provide insights into more rational chemotherapeutic regimens in clinical practice, and more effective approaches might be

  13. Expression of an oxalate decarboxylase impairs the necrotic effect induced by Nep1-like protein (NLP) of Moniliophthora perniciosa in transgenic tobacco.

    Science.gov (United States)

    da Silva, Leonardo F; Dias, Cristiano V; Cidade, Luciana C; Mendes, Juliano S; Pirovani, Carlos P; Alvim, Fátima C; Pereira, Gonçalo A G; Aragão, Francisco J L; Cascardo, Júlio C M; Costa, Marcio G C

    2011-07-01

    Oxalic acid (OA) and Nep1-like proteins (NLP) are recognized as elicitors of programmed cell death (PCD) in plants, which is crucial for the pathogenic success of necrotrophic plant pathogens and involves reactive oxygen species (ROS). To determine the importance of oxalate as a source of ROS for OA- and NLP-induced cell death, a full-length cDNA coding for an oxalate decarboxylase (FvOXDC) from the basidiomycete Flammulina velutipes, which converts OA into CO(2) and formate, was overexpressed in tobacco plants. The transgenic plants contained less OA and more formic acid compared with the control plants and showed enhanced resistance to cell death induced by exogenous OA and MpNEP2, an NLP of the hemibiotrophic fungus Moniliophthora perniciosa. This resistance was correlated with the inhibition of ROS formation in the transgenic plants inoculated with OA, MpNEP2, or a combination of both PCD elicitors. Taken together, these results have established a pivotal function for oxalate as a source of ROS required for the PCD-inducing activity of OA and NLP. The results also indicate that FvOXDC represents a potentially novel source of resistance against OA- and NLP-producing pathogens such as M. perniciosa, the causal agent of witches' broom disease of cacao (Theobroma cacao L.).

  14. Development and evaluation of task-specific NLP framework in China.

    Science.gov (United States)

    Ge, Caixia; Zhang, Yinsheng; Huang, Zhenzhen; Jia, Zheng; Ju, Meizhi; Duan, Huilong; Li, Haomin

    2015-01-01

    Natural language processing (NLP) has been designed to convert narrative text into structured data. Although some general NLP architectures have been developed, a task-specific NLP framework to facilitate the effective use of data is still a challenge in lexical resource limited regions, such as China. The purpose of this study is to design and develop a task-specific NLP framework to extract targeted information from particular documents by adopting dedicated algorithms on current limited lexical resources. In this framework, a shared and evolving ontology mechanism was designed. The result has shown that such a free text driven platform will accelerate the NLP technology acceptance in China.

  15. Coordinate regulation of the mother centriole component nlp by nek2 and plk1 protein kinases.

    Science.gov (United States)

    Rapley, Joseph; Baxter, Joanne E; Blot, Joelle; Wattam, Samantha L; Casenghi, Martina; Meraldi, Patrick; Nigg, Erich A; Fry, Andrew M

    2005-02-01

    Mitotic entry requires a major reorganization of the microtubule cytoskeleton. Nlp, a centrosomal protein that binds gamma-tubulin, is a G(2)/M target of the Plk1 protein kinase. Here, we show that human Nlp and its Xenopus homologue, X-Nlp, are also phosphorylated by the cell cycle-regulated Nek2 kinase. X-Nlp is a 213-kDa mother centriole-specific protein, implicating it in microtubule anchoring. Although constant in abundance throughout the cell cycle, it is displaced from centrosomes upon mitotic entry. Overexpression of active Nek2 or Plk1 causes premature displacement of Nlp from interphase centrosomes. Active Nek2 is also capable of phosphorylating and displacing a mutant form of Nlp that lacks Plk1 phosphorylation sites. Importantly, kinase-inactive Nek2 interferes with Plk1-induced displacement of Nlp from interphase centrosomes and displacement of endogenous Nlp from mitotic spindle poles, while active Nek2 stimulates Plk1 phosphorylation of Nlp in vitro. Unlike Plk1, Nek2 does not prevent association of Nlp with gamma-tubulin. Together, these results provide the first example of a protein involved in microtubule organization that is coordinately regulated at the G(2)/M transition by two centrosomal kinases. We also propose that phosphorylation by Nek2 may prime Nlp for phosphorylation by Plk1.

  16. Phylogenetic, expression and functional characterizations of the maize NLP transcription factor family reveal a role in nitrate assimilation and signaling.

    Science.gov (United States)

    Wang, Zhangkui; Zhang, Lei; Sun, Ci; Gu, Riliang; Mi, Guohua; Yuan, Lixing

    2018-01-24

    Although nitrate represents an important nitrogen (N) source for maize, a major crop of dryland areas, the molecular mechanisms of nitrate uptake and assimilation remain poorly understood. Here, we identified nine maize NIN-like protein (ZmNLP) genes and analyzed the function of one member, ZmNLP3.1, in nitrate nutrition and signaling. The NLP family genes were clustered into three clades in a phylogenic tree. Comparative genomic analysis showed that most ZmNLP genes had collinear relationships to the corresponding NLPs in rice, and that the expansion of the ZmNLP family resulted from segmental duplications in the maize genome. Quantitative PCR analysis revealed the expression of ZmNLP2.1, ZmNLP2.2, ZmNLP3.1, ZmNLP3.2, ZmNLP3.3, and ZmNLP3.4 was induced by nitrate in maize roots. The function of ZmNLP3.1 was investigated by overexpressing it in the Arabidopsis nlp7-1 mutant, which is defective in the AtNLP7 gene for nitrate signaling and assimilation. Ectopic expression of ZmNLP3.1 restored the N-deficient phenotypes of nlp7-1 under nitrate-replete conditions in terms of shoot biomass, root morphology and nitrate assimilation. Furthermore, the nitrate induction of NRT2.1, NIA1, and NiR1 gene expression was recovered in the 35S::ZmNLP3.1/nlp7-1 transgenic lines, indicating that ZmNLP3.1 plays essential roles in nitrate signaling. Taken together, these results suggest that ZmNLP3.1 plays an essential role in regulating nitrate signaling and assimilation processes, and represents a valuable candidate for developing transgenic maize cultivars with high N-use efficiency. This article is protected by copyright. All rights reserved.

  17. A neurolinguistic longitudinal study of a pure motor aphasia.

    Science.gov (United States)

    Clouzet, O; Pollak, A; Bianco, E; Mendilaharsu, C

    1976-01-01

    We have made a detailed neurolinguistic study of a patient with motor aphasia. The method used for his reeducation and the variants found in his language from a linguistic point of view through the course of several months are described. During this study we have found similarities with cases studied by Marcie reached by him in the errors common in patients with motor aphasia. But, contrary to Marcies, findings, we have found phonemes and allophones outside of the phonological and/or dilectal system of the language in this area. These phonemes and allophones are described together with the environment in which they appear.

  18. The Influence of Neurolinguistic Applications on Second Language Research: Reviewing the Issues and Refocusing the Debate

    Directory of Open Access Journals (Sweden)

    Masoud Mahmoodzadeh

    2015-03-01

    Full Text Available The influence of neurolinguistic applications on second language pedagogy has often been a controversial subject of dispute. As such, researchers in this field have faced with some blurred and conflicting views in terms of the pedagogical applicability of neurological discoveries for second language instruction. In light of this research-based concern, the current short paper attempts to review the related issues and refocus the current direction of the neurolinguistic-second language pedagogy debate. The paper also concludes with some suggestions made in favor of an alternative neurolinguistic outlook for L2 researchers.

  19. The role of centrosomal Nlp in the control of mitotic progression and tumourigenesis.

    Science.gov (United States)

    Li, J; Zhan, Q

    2011-05-10

    The human centrosomal ninein-like protein (Nlp) is a new member of the γ-tubulin complexes binding proteins (GTBPs) that is essential for proper execution of various mitotic events. The primary function of Nlp is to promote microtubule nucleation that contributes to centrosome maturation, spindle formation and chromosome segregation. Its subcellular localisation and protein stability are regulated by several crucial mitotic kinases, such as Plk1, Nek2, Cdc2 and Aurora B. Several lines of evidence have linked Nlp to human cancer. Deregulation of Nlp in cell models results in aberrant spindle, chromosomal missegregation and multinulei, and induces chromosomal instability and renders cells tumourigenic. Overexpression of Nlp induces anchorage-independent growth and immortalised primary cell transformation. In addition, we first demonstrate that the expression of Nlp is elevated primarily due to NLP gene amplification in human breast cancer and lung carcinoma. Consistently, transgenic mice overexpressing Nlp display spontaneous tumours in breast, ovary and testicle, and show rapid onset of radiation-induced lymphoma, indicating that Nlp is involved in tumourigenesis. This review summarises our current knowledge of physiological roles of Nlp, with an emphasis on its potentials in tumourigenesis.

  20. Sales Training for Army Recruiter Success: Sales Strategies and Skills Used by Excellent U. S. Army Recruiters

    Science.gov (United States)

    1987-11-01

    kills -Linguistic pattern~ Sales cycle, Communica tion s trategies Mode-H.R-g. Sales skills, {:( ~Expert kn0\\vlc dge1 ’ Neurolinguist ic~ Sales...Army recruiters. Neurolinguistic programming (NLP) was used as the protocol for modeling performance and acquiring information on the communication

  1. A combined NLP-differential evolution algorithm approach for the optimization of looped water distribution systems

    Science.gov (United States)

    Zheng, Feifei; Simpson, Angus R.; Zecchin, Aaron C.

    2011-08-01

    This paper proposes a novel optimization approach for the least cost design of looped water distribution systems (WDSs). Three distinct steps are involved in the proposed optimization approach. In the first step, the shortest-distance tree within the looped network is identified using the Dijkstra graph theory algorithm, for which an extension is proposed to find the shortest-distance tree for multisource WDSs. In the second step, a nonlinear programming (NLP) solver is employed to optimize the pipe diameters for the shortest-distance tree (chords of the shortest-distance tree are allocated the minimum allowable pipe sizes). Finally, in the third step, the original looped water network is optimized using a differential evolution (DE) algorithm seeded with diameters in the proximity of the continuous pipe sizes obtained in step two. As such, the proposed optimization approach combines the traditional deterministic optimization technique of NLP with the emerging evolutionary algorithm DE via the proposed network decomposition. The proposed methodology has been tested on four looped WDSs with the number of decision variables ranging from 21 to 454. Results obtained show the proposed approach is able to find optimal solutions with significantly less computational effort than other optimization techniques.

  2. Discovery of nitrate-CPK-NLP signalling in central nutrient-growth networks.

    Science.gov (United States)

    Liu, Kun-Hsiang; Niu, Yajie; Konishi, Mineko; Wu, Yue; Du, Hao; Sun Chung, Hoo; Li, Lei; Boudsocq, Marie; McCormack, Matthew; Maekawa, Shugo; Ishida, Tetsuya; Zhang, Chao; Shokat, Kevan; Yanagisawa, Shuichi; Sheen, Jen

    2017-05-18

    Nutrient signalling integrates and coordinates gene expression, metabolism and growth. However, its primary molecular mechanisms remain incompletely understood in plants and animals. Here we report unique Ca 2+ signalling triggered by nitrate with live imaging of an ultrasensitive biosensor in Arabidopsis leaves and roots. A nitrate-sensitized and targeted functional genomic screen identifies subgroup III Ca 2+ -sensor protein kinases (CPKs) as master regulators that orchestrate primary nitrate responses. A chemical switch with the engineered mutant CPK10(M141G) circumvents embryo lethality and enables conditional analyses of cpk10 cpk30 cpk32 triple mutants to define comprehensive nitrate-associated regulatory and developmental programs. Nitrate-coupled CPK signalling phosphorylates conserved NIN-LIKE PROTEIN (NLP) transcription factors to specify the reprogramming of gene sets for downstream transcription factors, transporters, nitrogen assimilation, carbon/nitrogen metabolism, redox, signalling, hormones and proliferation. Conditional cpk10 cpk30 cpk32 and nlp7 mutants similarly impair nitrate-stimulated system-wide shoot growth and root establishment. The nutrient-coupled Ca 2+ signalling network integrates transcriptome and cellular metabolism with shoot-root coordination and developmental plasticity in shaping organ biomass and architecture.

  3. TRANSLATION VS INTERPRETING IN THE PERSPECTIVE OF NEUROLINGUISTICS

    Directory of Open Access Journals (Sweden)

    Rochmat Susanto

    2017-12-01

    Full Text Available The following article aims 1 to explain the process of translating and interpreting in the perspective of neurolinguistics (explaining the process underlying the complexity which occur in human brain when translating and interpreting are performed and 2 to compare or to find out the similarities and differences between translating and interpreting based on the point of view. The process of translation and interpreting are mostly different in terms of neurolinguistics perspective. Translation involves graphic channel (ST which is processed through the eyes while interpreting involves phonic channel (SE which is processed through the ears. However both meaning contained in ST and SE are transmitted to wernicke area where the act of re-expressing meaning through choosing appropriate lexicon into TT or TE occurred. Afterward brocca area activates the upper motor nerve to move translator‘s hand to re-express the meaning into TT while in interpreting, it activates the lower motor nerve to move interpreter‘s mouth and other related speech organs to re-express the meaning into TE.

  4. Ensembles of NLP Tools for Data Element Extraction from Clinical Notes.

    Science.gov (United States)

    Kuo, Tsung-Ting; Rao, Pallavi; Maehara, Cleo; Doan, Son; Chaparro, Juan D; Day, Michele E; Farcas, Claudiu; Ohno-Machado, Lucila; Hsu, Chun-Nan

    2016-01-01

    Natural Language Processing (NLP) is essential for concept extraction from narrative text in electronic health records (EHR). To extract numerous and diverse concepts, such as data elements (i.e., important concepts related to a certain medical condition), a plausible solution is to combine various NLP tools into an ensemble to improve extraction performance. However, it is unclear to what extent ensembles of popular NLP tools improve the extraction of numerous and diverse concepts. Therefore, we built an NLP ensemble pipeline to synergize the strength of popular NLP tools using seven ensemble methods, and to quantify the improvement in performance achieved by ensembles in the extraction of data elements for three very different cohorts. Evaluation results show that the pipeline can improve the performance of NLP tools, but there is high variability depending on the cohort.

  5. Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.

    Science.gov (United States)

    Casenghi, Martina; Meraldi, Patrick; Weinhart, Ulrike; Duncan, Peter I; Körner, Roman; Nigg, Erich A

    2003-07-01

    In animal cells, most microtubules are nucleated at centrosomes. At the onset of mitosis, centrosomes undergo a structural reorganization, termed maturation, which leads to increased microtubule nucleation activity. Centrosome maturation is regulated by several kinases, including Polo-like kinase 1 (Plk1). Here, we identify a centrosomal Plk1 substrate, termed Nlp (ninein-like protein), whose properties suggest an important role in microtubule organization. Nlp interacts with two components of the gamma-tubulin ring complex and stimulates microtubule nucleation. Plk1 phosphorylates Nlp and disrupts both its centrosome association and its gamma-tubulin interaction. Overexpression of an Nlp mutant lacking Plk1 phosphorylation sites severely disturbs mitotic spindle formation. We propose that Nlp plays an important role in microtubule organization during interphase, and that the activation of Plk1 at the onset of mitosis triggers the displacement of Nlp from the centrosome, allowing the establishment of a mitotic scaffold with enhanced microtubule nucleation activity.

  6. Eudicot plant-specific sphingolipids determine host selectivity of microbial NLP cytolysins.

    Science.gov (United States)

    Lenarčič, Tea; Albert, Isabell; Böhm, Hannah; Hodnik, Vesna; Pirc, Katja; Zavec, Apolonija B; Podobnik, Marjetka; Pahovnik, David; Žagar, Ema; Pruitt, Rory; Greimel, Peter; Yamaji-Hasegawa, Akiko; Kobayashi, Toshihide; Zienkiewicz, Agnieszka; Gömann, Jasmin; Mortimer, Jenny C; Fang, Lin; Mamode-Cassim, Adiilah; Deleu, Magali; Lins, Laurence; Oecking, Claudia; Feussner, Ivo; Mongrand, Sébastien; Anderluh, Gregor; Nürnberger, Thorsten

    2017-12-15

    Necrosis and ethylene-inducing peptide 1-like (NLP) proteins constitute a superfamily of proteins produced by plant pathogenic bacteria, fungi, and oomycetes. Many NLPs are cytotoxins that facilitate microbial infection of eudicot, but not of monocot plants. Here, we report glycosylinositol phosphorylceramide (GIPC) sphingolipids as NLP toxin receptors. Plant mutants with altered GIPC composition were more resistant to NLP toxins. Binding studies and x-ray crystallography showed that NLPs form complexes with terminal monomeric hexose moieties of GIPCs that result in conformational changes within the toxin. Insensitivity to NLP cytolysins of monocot plants may be explained by the length of the GIPC head group and the architecture of the NLP sugar-binding site. We unveil early steps in NLP cytolysin action that determine plant clade-specific toxin selectivity. Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

  7. Retrospective Review Article: The Contribution of Neurolinguistics to Second and Foreign Language Theory and Practice.

    Science.gov (United States)

    Danesi, Marcel

    1990-01-01

    A review of some of the major works in neurolinguistics published during the last decade extrapolates many implications for second and foreign language theory and practice, covering such issues as hemispheric dominance, language processing, and bilingualism. (35 references) (CB)

  8. Comment Dire: A Neurolinguistic Approach to Beckett’s Bilingual Writings

    NARCIS (Netherlands)

    Kager, A.M.W.|info:eu-repo/dai/nl/411258419

    2015-01-01

    Recent studies from the field of neurolinguistics and psycholinguistics suggest that bilinguals and multilinguals are in many ways fundamentally different from monolinguals, a difference that starts with a different cerebral structure for language. This difference will constitute the point of

  9. Cdc2/cyclin B1 regulates centrosomal Nlp proteolysis and subcellular localization.

    Science.gov (United States)

    Zhao, Xuelian; Jin, Shunqian; Song, Yongmei; Zhan, Qimin

    2010-11-01

    The formation of proper mitotic spindles is required for appropriate chromosome segregation during cell division. Aberrant spindle formation often causes aneuploidy and results in tumorigenesis. However, the underlying mechanism of regulating spindle formation and chromosome separation remains to be further defined. Centrosomal Nlp (ninein-like protein) is a recently characterized BRCA1-regulated centrosomal protein and plays an important role in centrosome maturation and spindle formation. In this study, we show that Nlp can be phosphorylated by cell cycle protein kinase Cdc2/cyclin B1. The phosphorylation sites of Nlp are mapped at Ser185 and Ser589. Interestingly, the Cdc2/cyclin B1 phosphorylation site Ser185 of Nlp is required for its recognition by PLK1, which enable Nlp depart from centrosomes to allow the establishment of a mitotic scaffold at the onset of mitosis . PLK1 fails to dissociate the Nlp mutant lacking Ser185 from centrosome, suggesting that Cdc2/cyclin B1 might serve as a primary kinase of PLK1 in regulating Nlp subcellular localization. However, the phosphorylation at the site Ser589 by Cdc2/cyclin B1 plays an important role in Nlp protein stability probably due to its effect on protein degradation. Furthermore, we show that deregulated expression or subcellular localization of Nlp lead to multinuclei in cells, indicating that scheduled levels of Nlp and proper subcellular localization of Nlp are critical for successful completion of normal cell mitosis, These findings demonstrate that Cdc2/cyclin B1 is a key regulator in maintaining appropriate degradation and subcellular localization of Nlp, providing novel insights into understanding on the role of Cdc2/cyclin B1 in mitotic progression.

  10. Experimenting with semantic web services to understand the role of NLP technologies in healthcare.

    Science.gov (United States)

    Jagannathan, V

    2006-01-01

    NLP technologies can play a significant role in healthcare where a predominant segment of the clinical documentation is in text form. In a graduate course focused on understanding semantic web services at West Virginia University, a class project was designed with the purpose of exploring potential use for NLP-based abstraction of clinical documentation. The role of NLP-technology was simulated using human abstractors and various workflows were investigated using public domain workflow and semantic web service technologies. This poster explores the potential use of NLP and the role of workflow and semantic web technologies in developing healthcare IT environments.

  11. Canary: An NLP Platform for Clinicians and Researchers.

    Science.gov (United States)

    Malmasi, Shervin; Sandor, Nicolae L; Hosomura, Naoshi; Goldberg, Matt; Skentzos, Stephen; Turchin, Alexander

    2017-05-03

    Information Extraction methods can help discover critical knowledge buried in the vast repositories of unstructured clinical data. However, these methods are underutilized in clinical research, potentially due to the absence of free software geared towards clinicians with little technical expertise. The skills required for developing/using such software constitute a major barrier for medical researchers wishing to employ these methods. To address this, we have developed Canary, a free and open-source solution designed for users without natural language processing (NLP) or software engineering experience. It was designed to be fast and work out of the box via a user-friendly graphical interface.

  12. [The language disorders in schizophrenia in neurolinguistic and psycholinguistic perspectives].

    Science.gov (United States)

    Piovan, Cristiano

    2012-01-01

    The descriptive psychopathology has classically equated the language with the formal aspects of thought. Recent developments in experimental and clinical research have emphasized the study of the language as a specific communicative ability. Within the framework of cognitive neuropsychology, the development of innovative research models, such as those based on the mentalizing ability, has allowed to formulate new hypotheses on the pathogenetic aspects of schizophrenia. Furthermore, mentalizing ability appears to be a basic skill for the pragmatic dimension of language. The author, after a brief description of the methods of investigation of neurolinguistics and psycholinguistics, presents a review of recent studies obtained by consulting the PubMed and PsycINFO databases. Finally, he focuses on the relationship between research findings and issues related to clinical practice.

  13. Aphasia diagrams: a new notational scheme for representing neurolinguistic deficits.

    Science.gov (United States)

    Westbury, C; Bub, D

    1998-01-01

    Models of language processing are becoming extremely complex. As a result, it has become very difficult to develop a thorough understanding of even a single patient's deficits, let alone to represent those deficits in a way which renders their significance apparent to others. In this paper, we describe and demonstrate the use of a notational system which has been developed specifically for representing the complexities of neurolinguistic deficits. The notational system is simple to learn and to use and may easily be extended and adapted to different models of language processing. It may also be used to represent the results from other nonlinguistic neuropsychological batteries which are composed of tightly interdependent subtests with many related factors included in each subtest. Despite its simplicity, the notational system has proven itself in the field as a useful tool for rendering complex deficits more easily interpretable.

  14. Neurolinguistic Relativity: How Language Flexes Human Perception and Cognition.

    Science.gov (United States)

    Thierry, Guillaume

    2016-09-01

    The time has come, perhaps, to go beyond merely acknowledging that language is a core manifestation of the workings of the human mind and that it relates interactively to all aspects of thinking. The issue, thus, is not to decide whether language and human thought may be ineluctably linked (they just are), but rather to determine what the characteristics of this relationship may be and to understand how language influences-and may be influenced by-nonverbal information processing. In an attempt to demystify linguistic relativity, I review neurolinguistic studies from our research group showing a link between linguistic distinctions and perceptual or conceptual processing. On the basis of empirical evidence showing effects of terminology on perception, language-idiosyncratic relationships in semantic memory, grammatical skewing of event conceptualization, and unconscious modulation of executive functioning by verbal input, I advocate a neurofunctional approach through which we can systematically explore how languages shape human thought.

  15. A neurolinguistic model for the study of aphasia.

    Science.gov (United States)

    Gainotti, G; Miceli, G; Caltagirone, C

    1977-01-01

    After having briefly discussed some of the most important models that are now used to understand or to classify the aphasic troubles, the authors explain the neurolinguistic model they are actually using to study some aspects of aphasics' verbal and nonverbal behavior. This theoretical model distinguishes proper linguistic from extralinguistic disturbances in the various clinical forms of aphasia. The existence in aphasia of extralinguistic components that might, in some way, influence verbal performances, is accepted by most authors. Much less obvious is the existence, at least in some clinical forms of aphasia, of proper linguistic (competence) disturbances. Our theoretical model assumes that in most clinical forms of aphasia some impairment of the semantic (lexical) structures of language exists, and it maintains that this trouble can be found both at the expressive and at the receptive level, both in verbal and in nonverbal tasks. Th results of some experimental investigations which give some support to this theoretical model, are briefly discussed.

  16. Neuro-Linguistic Programming for Leaders and Managers

    OpenAIRE

    Tosey, Paul

    2010-01-01

    On few occasions in the history of modern management have leadership skills been in such sharp focus as they are now. The ability to direct often very large and diverse organizations; to make sense of the complex and turbulent markets and environments in which you operate; and to adapt and learn seems at an all time premium. The premise behind the fifth edition of this influential Handbook is that leadership, management and organizational development are all parts of the same process; enhanci...

  17. Book review. Neurolinguistics. An Introduction to Spoken Language Processing and its Disorders, John Ingram. Cambridge University Press, Cambridge (Cambridge Textbooks in Linguistics) . xxi + 420 pp., ISBN 978-0-521-79640-8 (pb)

    NARCIS (Netherlands)

    Schiller, N.O.

    2009-01-01

    The present textbook is one of the few recent textbooks in the area of neurolinguistics and will be welcomed by teachers of neurolinguistic courses as well as researchers interested in the topic. Neurolinguistics is a huge area, and the boundaries between psycho- and neurolinguistics are not sharp.

  18. BRCA1 Interaction of Centrosomal Protein Nlp Is Required for Successful Mitotic Progression*♦

    Science.gov (United States)

    Jin, Shunqian; Gao, Hua; Mazzacurati, Lucia; Wang, Yang; Fan, Wenhong; Chen, Qiang; Yu, Wei; Wang, Mingrong; Zhu, Xueliang; Zhang, Chuanmao; Zhan, Qimin

    2009-01-01

    Breast cancer susceptibility gene BRCA1 is implicated in the control of mitotic progression, although the underlying mechanism(s) remains to be further defined. Deficiency of BRCA1 function leads to disrupted mitotic machinery and genomic instability. Here, we show that BRCA1 physically interacts and colocalizes with Nlp, an important molecule involved in centrosome maturation and spindle formation. Interestingly, Nlp centrosomal localization and its protein stability are regulated by normal cellular BRCA1 function because cells containing BRCA1 mutations or silenced for endogenous BRCA1 exhibit disrupted Nlp colocalization to centrosomes and enhanced Nlp degradation. Its is likely that the BRCA1 regulation of Nlp stability involves Plk1 suppression. Inhibition of endogenous Nlp via the small interfering RNA approach results in aberrant spindle formation, aborted chromosomal segregation, and aneuploidy, which mimic the phenotypes of disrupted BRCA1. Thus, BRCA1 interaction of Nlp might be required for the successful mitotic progression, and abnormalities of Nlp lead to genomic instability. PMID:19509300

  19. NLP is a novel transcription regulator involved in VSG expression site control in Trypanosoma brucei.

    Science.gov (United States)

    Narayanan, Mani Shankar; Kushwaha, Manish; Ersfeld, Klaus; Fullbrook, Alexander; Stanne, Tara M; Rudenko, Gloria

    2011-03-01

    Trypanosoma brucei mono-allelically expresses one of approximately 1500 variant surface glycoprotein (VSG) genes while multiplying in the mammalian bloodstream. The active VSG is transcribed by RNA polymerase I in one of approximately 15 telomeric VSG expression sites (ESs). T. brucei is unusual in controlling gene expression predominantly post-transcriptionally, and how ESs are mono-allelically controlled remains a mystery. Here we identify a novel transcription regulator, which resembles a nucleoplasmin-like protein (NLP) with an AT-hook motif. NLP is key for ES control in bloodstream form T. brucei, as NLP knockdown results in 45- to 65-fold derepression of the silent VSG221 ES. NLP is also involved in repression of transcription in the inactive VSG Basic Copy arrays, minichromosomes and procyclin loci. NLP is shown to be enriched on the 177- and 50-bp simple sequence repeats, the non-transcribed regions around rDNA and procyclin, and both active and silent ESs. Blocking NLP synthesis leads to downregulation of the active ES, indicating that NLP plays a role in regulating appropriate levels of transcription of ESs in both their active and silent state. Discovery of the unusual transcription regulator NLP provides new insight into the factors that are critical for ES control.

  20. Robo-Sensei's NLP-Based Error Detection and Feedback Generation

    Science.gov (United States)

    Nagata, Noriko

    2009-01-01

    This paper presents a new version of Robo-Sensei's NLP (Natural Language Processing) system which updates the version currently available as the software package "ROBO-SENSEI: Personal Japanese Tutor" (Nagata, 2004). Robo-Sensei's NLP system includes a lexicon, a morphological generator, a word segmentor, a morphological parser, a syntactic…

  1. Synthetic event-related potentials: a computational bridge between neurolinguistic models and experiments.

    Science.gov (United States)

    Barrès, Victor; Simons, Arthur; Arbib, Michael

    2013-01-01

    Our previous work developed Synthetic Brain Imaging to link neural and schema network models of cognition and behavior to PET and fMRI studies of brain function. We here extend this approach to Synthetic Event-Related Potentials (Synthetic ERP). Although the method is of general applicability, we focus on ERP correlates of language processing in the human brain. The method has two components: Phase 1: To generate cortical electro-magnetic source activity from neural or schema network models; and Phase 2: To generate known neurolinguistic ERP data (ERP scalp voltage topographies and waveforms) from putative cortical source distributions and activities within a realistic anatomical model of the human brain and head. To illustrate the challenges of Phase 2 of the methodology, spatiotemporal information from Friederici's 2002 model of auditory language comprehension was used to define cortical regions and time courses of activation for implementation within a forward model of ERP data. The cortical regions from the 2002 model were modeled using atlas-based masks overlaid on the MNI high definition single subject cortical mesh. The electromagnetic contribution of each region was modeled using current dipoles whose position and orientation were constrained by the cortical geometry. In linking neural network computation via EEG forward modeling to empirical results in neurolinguistics, we emphasize the need for neural network models to link their architecture to geometrically sound models of the cortical surface, and the need for conceptual models to refine and adopt brain-atlas based approaches to allow precise brain anchoring of their modules. The detailed analysis of Phase 2 sets the stage for a brief introduction to Phase 1 of the program, including the case for a schema-theoretic approach to language production and perception presented in detail elsewhere. Unlike Dynamic Causal Modeling (DCM) and Bojak's mean field model, Synthetic ERP builds on models of networks

  2. Language and human nature: Kurt Goldstein's neurolinguistic foundation of a holistic philosophy.

    Science.gov (United States)

    Ludwig, David

    2012-01-01

    Holism in interwar Germany provides an excellent example for social and political influences on scientific developments. Deeply impressed by the ubiquitous invocation of a cultural crisis, biologists, physicians, and psychologists presented holistic accounts as an alternative to the "mechanistic worldview" of the nineteenth century. Although the ideological background of these accounts is often blatantly obvious, many holistic scientists did not content themselves with a general opposition to a mechanistic worldview but aimed at a rational foundation of their holistic projects. This article will discuss the work of Kurt Goldstein, who is known for both his groundbreaking contributions to neuropsychology and his holistic philosophy of human nature. By focusing on Goldstein's neurolinguistic research, I want to reconstruct the empirical foundations of his holistic program without ignoring its cultural background. In this sense, Goldstein's work provides a case study for the formation of a scientific theory through the complex interplay between specific empirical evidences and the general cultural developments of the Weimar Republic. © 2012 Wiley Periodicals, Inc.

  3. Book review. Neurolinguistics. An Introduction to Spoken Language Processing and its Disorders, John Ingram. Cambridge University Press, Cambridge (Cambridge Textbooks in Linguistics) (2007). xxi + 420 pp., ISBN 978-0-521-79640-8 (pb)

    OpenAIRE

    Schiller, N.O.

    2009-01-01

    The present textbook is one of the few recent textbooks in the area of neurolinguistics and will be welcomed by teachers of neurolinguistic courses as well as researchers interested in the topic. Neurolinguistics is a huge area, and the boundaries between psycho- and neurolinguistics are not sharp. Often the term neurolinguistics is used to refer to research involving neuropsychological patients suffering from some sort of language disorder or impairment. Also, the term neuro- rather than psy...

  4. The NLP toxin family in Phytophthora sojae includes rapidly evolving groups that lack necrosis-inducing activity.

    Science.gov (United States)

    Dong, Suomeng; Kong, Guanghui; Qutob, Dinah; Yu, Xiaoli; Tang, Junli; Kang, Jixiong; Dai, Tingting; Wang, Hai; Gijzen, Mark; Wang, Yuanchao

    2012-07-01

    Necrosis- and ethylene-inducing-like proteins (NLP) are widely distributed in eukaryotic and prokaryotic plant pathogens and are considered to be important virulence factors. We identified, in total, 70 potential Phytophthora sojae NLP genes but 37 were designated as pseudogenes. Sequence alignment of the remaining 33 NLP delineated six groups. Three of these groups include proteins with an intact heptapeptide (Gly-His-Arg-His-Asp-Trp-Glu) motif, which is important for necrosis-inducing activity, whereas the motif is not conserved in the other groups. In total, 19 representative NLP genes were assessed for necrosis-inducing activity by heterologous expression in Nicotiana benthamiana. Surprisingly, only eight genes triggered cell death. The expression of the NLP genes in P. sojae was examined, distinguishing 20 expressed and 13 nonexpressed NLP genes. Real-time reverse-transcriptase polymerase chain reaction results indicate that most NLP are highly expressed during cyst germination and infection stages. Amino acid substitution ratios (Ka/Ks) of 33 NLP sequences from four different P. sojae strains resulted in identification of positive selection sites in a distinct NLP group. Overall, our study indicates that expansion and pseudogenization of the P. sojae NLP family results from an ongoing birth-and-death process, and that varying patterns of expression, necrosis-inducing activity, and positive selection suggest that NLP have diversified in function.

  5. Describing visual scenes: towards a neurolinguistics based on construction grammar.

    Science.gov (United States)

    Arbib, Michael A; Lee, Jinyong

    2008-08-15

    The present paper is part of a larger effort to locate the production and perception of language within the broader context of brain mechanisms for action and perception more generally. Here we model function in terms of the competition and cooperation of schemas. We use the task of describing visual scenes to explore the suitability of Construction Grammar as an appropriate framework for a schema-based linguistics. We recall the early VISIONS model of schema-based computer analysis of static visual scenes and then introduce SemRep as a graphical representation of dynamic visual scenes designed to support the generation of varied descriptions of episodes. We report preliminary results on implementing the production of sentences using Template Construction Grammar (TCG), a new form of construction grammar distinguished by its use of SemRep to express semantics. We summarize data on neural correlates relevant to future work on TCG within the context of neurolinguistics, and show how the relation between SemRep and TCG can serve as the basis for modeling language comprehension.

  6. Neurolinguistics: Structure, Function, and Connectivity in the Bilingual Brain.

    Science.gov (United States)

    Wong, Becky; Yin, Bin; O'Brien, Beth

    2016-01-01

    Advances in neuroimaging techniques and analytic methods have led to a proliferation of studies investigating the impact of bilingualism on the cognitive and brain systems in humans. Lately, these findings have attracted much interest and debate in the field, leading to a number of recent commentaries and reviews. Here, we contribute to the ongoing discussion by compiling and interpreting the plethora of findings that relate to the structural, functional, and connective changes in the brain that ensue from bilingualism. In doing so, we integrate theoretical models and empirical findings from linguistics, cognitive/developmental psychology, and neuroscience to examine the following issues: (1) whether the language neural network is different for first (dominant) versus second (nondominant) language processing; (2) the effects of bilinguals' executive functioning on the structure and function of the "universal" language neural network; (3) the differential effects of bilingualism on phonological, lexical-semantic, and syntactic aspects of language processing on the brain; and (4) the effects of age of acquisition and proficiency of the user's second language in the bilingual brain, and how these have implications for future research in neurolinguistics.

  7. Neurolinguistics: Structure, Function, and Connectivity in the Bilingual Brain

    Directory of Open Access Journals (Sweden)

    Becky Wong

    2016-01-01

    Full Text Available Advances in neuroimaging techniques and analytic methods have led to a proliferation of studies investigating the impact of bilingualism on the cognitive and brain systems in humans. Lately, these findings have attracted much interest and debate in the field, leading to a number of recent commentaries and reviews. Here, we contribute to the ongoing discussion by compiling and interpreting the plethora of findings that relate to the structural, functional, and connective changes in the brain that ensue from bilingualism. In doing so, we integrate theoretical models and empirical findings from linguistics, cognitive/developmental psychology, and neuroscience to examine the following issues: (1 whether the language neural network is different for first (dominant versus second (nondominant language processing; (2 the effects of bilinguals’ executive functioning on the structure and function of the “universal” language neural network; (3 the differential effects of bilingualism on phonological, lexical-semantic, and syntactic aspects of language processing on the brain; and (4 the effects of age of acquisition and proficiency of the user’s second language in the bilingual brain, and how these have implications for future research in neurolinguistics.

  8. A pragmatic approach to neurolinguistics: requests (re)considered.

    Science.gov (United States)

    Stemmer, B

    1994-05-01

    In recent years there has been a series of studies in the field of neurolinguistics and neuropsychology investigating the comprehension and interpretation of indirect requests predominantly in right brain-damaged individuals. Although the findings of these studies seem to suggest that indirect requests may be perceived, comprehended, judged, or interpreted differently by some right brain-damaged individuals, until today no coherent picture pertaining to the description of the phenomenon under investigation has emerged. One reason for this dissatisfying situation may be that the features contributing to the interpretation of a request in terms of its level of directness have not been sufficiently investigated. In addition, the stimuli on which the experiments were based are not always clear-cut or specific if viewed within the framework of pragmatic theory. The article provides an introduction to some aspects of pragmatic theory and discusses five major studies on request comprehension in brain-damaged patients with reference to the components relevant to the realization of requests. Finally, suggestions concerning future research are made.

  9. A neurolinguistic study of autistic children employing dichotic listening.

    Science.gov (United States)

    Hayashi, M; Takamura, I; Kohara, H; Yamazaki, K

    1989-09-01

    A neurolinguistic study of 20 high functioning right-handed autistic children (19 males and 1 female) was carried out using a dichotic listening test of two-syllabic meaningful words with which to detect the level of binaural separation ability and the condition of hemispheric lateralization of language by examining the degree of ear advantage. The autistic children ranged from 5 to 15 years in age. Their IQ ranged from mildly retarded to normal. (The mean IQ was 67.6 and the mean mental age was 5 yr. 9 mo.). We compared them with non-autistic mentally retarded and normal children as controls, being matched by mental age and right handedness. The autistic children were found to be significantly lower on the level of binaural separation ability than the controls and to have a clearly higher incidence of a left ear advantage than the controls. The autistic and mentally retarded children showed lower advantage than normal children. These results indicate that the autistic children have a dysfunction or immaturity of the central auditory nervous system and an abnormality in the process of hemispheric lateralization of language.

  10. Dyslexia, neurolinguistic ability, and anatomical variation of the planum temporale.

    Science.gov (United States)

    Morgan, A E; Hynd, G W

    1998-06-01

    This article addresses the relationship between patterns of planum temporale symmetry/asymmetry and dyslexia and neurolinguistic abilities. Considerable research indicates that dyslexic individuals typically do not display the predominant pattern of leftward planum temporale asymmetry. Variable findings on the structural basis of symmetry are due partially to measurement issues, which are examined in some detail in this critical review. The physiological basis of symmetry may be reduced neuronal elimination in the right planum, although other alternatives are offered. Theories are offered to explain how symmetrical plana are related to dyslexia, and it is evident that symmetrical plana are not sufficient to produce dyslexia. However, some evidence suggests that nonleftward plana asymmetry is associated with deficits in verbal comprehension, phonological decoding, and expressive language. It is concluded that nonleftward asymmetry is associated with linguistic deficits, but that explanatory theories need to be further developed. Among the many issues that need to be addressed, future research needs to determine whether the relationship between patterns of planum temporale symmetry/asymmetry and linguistic ability is specific to dyslexia or if asymmetry covaries lawfully with linguistic abilities in nondyslexic populations.

  11. Semantic characteristics of NLP-extracted concepts in clinical notes vs. biomedical literature.

    Science.gov (United States)

    Wu, Stephen; Liu, Hongfang

    2011-01-01

    Natural language processing (NLP) has become crucial in unlocking information stored in free text, from both clinical notes and biomedical literature. Clinical notes convey clinical information related to individual patient health care, while biomedical literature communicates scientific findings. This work focuses on semantic characterization of texts at an enterprise scale, comparing and contrasting the two domains and their NLP approaches. We analyzed the empirical distributional characteristics of NLP-discovered named entities in Mayo Clinic clinical notes from 2001-2010, and in the 2011 MetaMapped Medline Baseline. We give qualitative and quantitative measures of domain similarity and point to the feasibility of transferring resources and techniques. An important by-product for this study is the development of a weighted ontology for each domain, which gives distributional semantic information that may be used to improve NLP applications.

  12. v3NLP Framework: Tools to Build Applications for Extracting Concepts from Clinical Text.

    Science.gov (United States)

    Divita, Guy; Carter, Marjorie E; Tran, Le-Thuy; Redd, Doug; Zeng, Qing T; Duvall, Scott; Samore, Matthew H; Gundlapalli, Adi V

    2016-01-01

    Substantial amounts of clinically significant information are contained only within the narrative of the clinical notes in electronic medical records. The v3NLP Framework is a set of "best-of-breed" functionalities developed to transform this information into structured data for use in quality improvement, research, population health surveillance, and decision support. MetaMap, cTAKES and similar well-known natural language processing (NLP) tools do not have sufficient scalability out of the box. The v3NLP Framework evolved out of the necessity to scale-up these tools up and provide a framework to customize and tune techniques that fit a variety of tasks, including document classification, tuned concept extraction for specific conditions, patient classification, and information retrieval. Beyond scalability, several v3NLP Framework-developed projects have been efficacy tested and benchmarked. While v3NLP Framework includes annotators, pipelines and applications, its functionalities enable developers to create novel annotators and to place annotators into pipelines and scaled applications. The v3NLP Framework has been successfully utilized in many projects including general concept extraction, risk factors for homelessness among veterans, and identification of mentions of the presence of an indwelling urinary catheter. Projects as diverse as predicting colonization with methicillin-resistant Staphylococcus aureus and extracting references to military sexual trauma are being built using v3NLP Framework components. The v3NLP Framework is a set of functionalities and components that provide Java developers with the ability to create novel annotators and to place those annotators into pipelines and applications to extract concepts from clinical text. There are scale-up and scale-out functionalities to process large numbers of records.

  13. A pharmacological study of NLP-12 neuropeptide signaling in free-living and parasitic nematodes.

    Science.gov (United States)

    Peeters, Lise; Janssen, Tom; De Haes, Wouter; Beets, Isabel; Meelkop, Ellen; Grant, Warwick; Schoofs, Liliane

    2012-03-01

    NLP-12a and b have been identified as cholecystokinin/sulfakinin-like neuropeptides in the free-living nematode Caenorhabditis elegans. They are suggested to play an important role in the regulation of digestive enzyme secretion and fat storage. This study reports on the identification and characterization of an NLP-12-like peptide precursor gene in the rat parasitic nematode Strongyloides ratti. The S. ratti NLP-12 peptides are able to activate both C. elegans CKR-2 receptor isoforms in a dose-dependent way with affinities in the same nanomolar range as the native C. elegans NLP-12 peptides. The C-terminal RPLQFamide sequence motif of the NLP-12 peptides is perfectly conserved between free-living and parasitic nematodes. Based on systemic amino acid replacements the Arg-, Leu- and Phe- residues appear to be critical for high-affinity receptor binding. Finally, a SAR analysis revealed the essential pharmacophore in C. elegans NLP-12b to be the pentapeptide RPLQFamide. Copyright © 2011 Elsevier Inc. All rights reserved.

  14. Metonymy as Referential Dependency: Psycholinguistic and Neurolinguistic Arguments for a Unified Linguistic Treatment

    Science.gov (United States)

    Piñango, Maria M.; Zhang, Muye; Foster-Hanson, Emily; Negishi, Michiro; Lacadie, Cheryl; Constable, R. Todd

    2017-01-01

    We examine metonymy at psycho- and neurolinguistic levels, seeking to adjudicate between two possible processing implementations (one- vs. two-mechanism). We compare highly conventionalized "systematic metonymy" (producer-for-product: "All freshmen read 'O'Connell'") to lesser-conventionalized "circumstantial…

  15. Neurolinguistic Annotated Bibliography (Brain Research and Language Function) with Implications for Education.

    Science.gov (United States)

    Davis, Wesley K.

    This bibliography presents annotations of 91 journal articles, books, chapters in books, and conference papers dating from 1967 to 1984 concerning neurolinguistics, language processing, and educational implications of brain research. The annotated bibliography includes eight items on neuroanatomy and language function; 20 items on neurolinguistics…

  16. A Neuro-Linguistic Model for Speech Recognition in Tone Language

    African Journals Online (AJOL)

    Firstly, we identified and specify entities in the speech recognition process using a neuro-linguistic approach. This approach not only offers a non-conflict degree for different speech recognition situation, it also provide stable integration mechanism for various level of speech unit. Secondly, this work is the first to illustrate ...

  17. Comment Dire: a Neurolinguistic Approach to Beckett's Bilingual Writings

    Science.gov (United States)

    Kager, Maria

    2015-01-01

    Recent studies from the field of neurolinguistics and psycholinguistics suggest that bilinguals and multilinguals are in many ways fundamentally different from monolinguals, a difference that starts with a different cerebral structure for language. This difference will constitute the point of departure for my paper: If multilingual people are…

  18. Interacting TCP and NLP transcription factors control plant responses to nitrate availability.

    Science.gov (United States)

    Guan, Peizhu; Ripoll, Juan-José; Wang, Renhou; Vuong, Lam; Bailey-Steinitz, Lindsay J; Ye, Dening; Crawford, Nigel M

    2017-02-28

    Plants have evolved adaptive strategies that involve transcriptional networks to cope with and survive environmental challenges. Key transcriptional regulators that mediate responses to environmental fluctuations in nitrate have been identified; however, little is known about how these regulators interact to orchestrate nitrogen (N) responses and cell-cycle regulation. Here we report that teosinte branched1/cycloidea/proliferating cell factor1-20 (TCP20) and NIN-like protein (NLP) transcription factors NLP6 and NLP7, which act as activators of nitrate assimilatory genes, bind to adjacent sites in the upstream promoter region of the nitrate reductase gene, NIA1 , and physically interact under continuous nitrate and N-starvation conditions. Regions of these proteins necessary for these interactions were found to include the type I/II Phox and Bem1p (PB1) domains of NLP6&7, a protein-interaction module conserved in animals for nutrient signaling, and the histidine- and glutamine-rich domain of TCP20, which is conserved across plant species. Under N starvation, TCP20-NLP6&7 heterodimers accumulate in the nucleus, and this coincides with TCP20 and NLP6&7-dependent up-regulation of nitrate assimilation and signaling genes and down-regulation of the G 2 /M cell-cycle marker gene, CYCB1;1 TCP20 and NLP6&7 also support root meristem growth under N starvation. These findings provide insights into how plants coordinate responses to nitrate availability, linking nitrate assimilation and signaling with cell-cycle progression.

  19. Clinical documentation variations and NLP system portability: a case study in asthma birth cohorts across institutions.

    Science.gov (United States)

    Sohn, Sunghwan; Wang, Yanshan; Wi, Chung-Il; Krusemark, Elizabeth A; Ryu, Euijung; Ali, Mir H; Juhn, Young J; Liu, Hongfang

    2017-11-30

    To assess clinical documentation variations across health care institutions using different electronic medical record systems and investigate how they affect natural language processing (NLP) system portability. Birth cohorts from Mayo Clinic and Sanford Children's Hospital (SCH) were used in this study (n = 298 for each). Documentation variations regarding asthma between the 2 cohorts were examined in various aspects: (1) overall corpus at the word level (ie, lexical variation), (2) topics and asthma-related concepts (ie, semantic variation), and (3) clinical note types (ie, process variation). We compared those statistics and explored NLP system portability for asthma ascertainment in 2 stages: prototype and refinement. There exist notable lexical variations (word-level similarity = 0.669) and process variations (differences in major note types containing asthma-related concepts). However, semantic-level corpora were relatively homogeneous (topic similarity = 0.944, asthma-related concept similarity = 0.971). The NLP system for asthma ascertainment had an F-score of 0.937 at Mayo, and produced 0.813 (prototype) and 0.908 (refinement) when applied at SCH. The criteria for asthma ascertainment are largely dependent on asthma-related concepts. Therefore, we believe that semantic similarity is important to estimate NLP system portability. As the Mayo Clinic and SCH corpora were relatively homogeneous at a semantic level, the NLP system, developed at Mayo Clinic, was imported to SCH successfully with proper adjustments to deal with the intrinsic corpus heterogeneity.

  20. The neuropeptide NLP-22 regulates a sleep-like state in Caenorhabditis elegans.

    Science.gov (United States)

    Nelson, M D; Trojanowski, N F; George-Raizen, J B; Smith, C J; Yu, C-C; Fang-Yen, C; Raizen, D M

    2013-01-01

    Neuropeptides have central roles in the regulation of homoeostatic behaviours such as sleep and feeding. Caenorhabditis elegans displays sleep-like quiescence of locomotion and feeding during a larval transition stage called lethargus and feeds during active larval and adult stages. Here we show that the neuropeptide NLP-22 is a regulator of Caenorhabditis elegans sleep-like quiescence observed during lethargus. nlp-22 shows cyclical mRNA expression in synchrony with lethargus; it is regulated by LIN-42, an orthologue of the core circadian protein PERIOD; and it is expressed solely in the two RIA interneurons. nlp-22 and the RIA interneurons are required for normal lethargus quiescence, and forced expression of nlp-22 during active stages causes anachronistic locomotion and feeding quiescence. Optogenetic stimulation of the RIA interneurons has a movement-promoting effect, demonstrating functional complexity in a single-neuron type. Our work defines a quiescence-regulating role for NLP-22 and expands our knowledge of the neural circuitry controlling Caenorhabditis elegans behavioural quiescence.

  1. Expression of Caenorhabditis elegans antimicrobial peptide NLP-31 in Escherichia coli

    Science.gov (United States)

    Lim, Mei-Perng; Nathan, Sheila

    2014-09-01

    Burkholderia pseudomallei is the causative agent of melioidosis, a fulminant disease endemic in Southeast Asia and Northern Australia. The standardized form of therapy is antibiotics treatment; however, the bacterium has become increasingly resistant to these antibiotics. This has spurred the need to search for alternative therapeutic agents. Antimicrobial peptides (AMPs) are small proteins that possess broad-spectrum antimicrobial activity. In a previous study, the nematode Caenorhabditis elegans was infected by B. pseudomallei and a whole animal transcriptome analysis identified a number of AMP-encoded genes which were induced significantly in the infected worms. One of the AMPs identified is NLP-31 and to date, there are no reports of anti-B. pseudomallei activity demonstrated by NLP-31. To produce NLP-31 protein for future studies, the gene encoding for NLP-31 was cloned into the pET32b expression vector and transformed into Escherichia coli BL21(DE3). Protein expression was induced with 1 mM IPTG for 20 hours at 20°C and recombinant NLP-31 was detected in the soluble fraction. Taken together, a simple optimized heterologous production of AMPs in an E. coli expression system has been successfully developed.

  2. The NlpD lipoprotein is a novel Yersinia pestis virulence factor essential for the development of plague.

    Directory of Open Access Journals (Sweden)

    Avital Tidhar

    Full Text Available Yersinia pestis is the causative agent of plague. Previously we have isolated an attenuated Y. pestis transposon insertion mutant in which the pcm gene was disrupted. In the present study, we investigated the expression and the role of pcm locus genes in Y. pestis pathogenesis using a set of isogenic surE, pcm, nlpD and rpoS mutants of the fully virulent Kimberley53 strain. We show that in Y. pestis, nlpD expression is controlled from elements residing within the upstream genes surE and pcm. The NlpD lipoprotein is the only factor encoded from the pcm locus that is essential for Y. pestis virulence. A chromosomal deletion of the nlpD gene sequence resulted in a drastic reduction in virulence to an LD(50 of at least 10(7 cfu for subcutaneous and airway routes of infection. The mutant was unable to colonize mouse organs following infection. The filamented morphology of the nlpD mutant indicates that NlpD is involved in cell separation; however, deletion of nlpD did not affect in vitro growth rate. Trans-complementation experiments with the Y. pestis nlpD gene restored virulence and all other phenotypic defects. Finally, we demonstrated that subcutaneous administration of the nlpD mutant could protect animals against bubonic and primary pneumonic plague. Taken together, these results demonstrate that Y. pestis NlpD is a novel virulence factor essential for the development of bubonic and pneumonic plague. Further, the nlpD mutant is superior to the EV76 prototype live vaccine strain in immunogenicity and in conferring effective protective immunity. Thus it could serve as a basis for a very potent live vaccine against bubonic and pneumonic plague.

  3. Finding 'Evidence of Absence' in Medical Notes: Using NLP for Clinical Inferencing.

    Science.gov (United States)

    Carter, Marjorie E; Divita, Guy; Redd, Andrew; Rubin, Michael A; Samore, Matthew H; Gupta, Kalpana; Trautner, Barbara W; Gundlapalli, Adi V

    2016-01-01

    Extracting evidence of the absence of a target of interest from medical text can be useful in clinical inferencing. The purpose of our study was to develop a natural language processing (NLP) pipelineto identify the presence of indwelling urinary catheters from electronic medical notes to aid in detection of catheter-associated urinary tract infections (CAUTI). Finding clear evidence that a patient does not have an indwelling urinary catheter is useful in making a determination regarding CAUTI. We developed a lexicon of seven core concepts to infer the absence of a urinary catheter. Of the 990,391 concepts extractedby NLP from a large corpus of 744,285 electronic medical notes from 5589 hospitalized patients, 63,516 were labeled as evidence of absence.Human review revealed three primary causes for false negatives. The lexicon and NLP pipeline were refined using this information, resulting in outputs with an acceptable false positive rate of 11%.

  4. Scaling-up NLP Pipelines to Process Large Corpora of Clinical Notes.

    Science.gov (United States)

    Divita, G; Carter, M; Redd, A; Zeng, Q; Gupta, K; Trautner, B; Samore, M; Gundlapalli, A

    2015-01-01

    This article is part of the Focus Theme of Methods of Information in Medicine on "Big Data and Analytics in Healthcare". This paper describes the scale-up efforts at the VA Salt Lake City Health Care System to address processing large corpora of clinical notes through a natural language processing (NLP) pipeline. The use case described is a current project focused on detecting the presence of an indwelling urinary catheter in hospitalized patients and subsequent catheter-associated urinary tract infections. An NLP algorithm using v3NLP was developed to detect the presence of an indwelling urinary catheter in hospitalized patients. The algorithm was tested on a small corpus of notes on patients for whom the presence or absence of a catheter was already known (reference standard). In planning for a scale-up, we estimated that the original algorithm would have taken 2.4 days to run on a larger corpus of notes for this project (550,000 notes), and 27 days for a corpus of 6 million records representative of a national sample of notes. We approached scaling-up NLP pipelines through three techniques: pipeline replication via multi-threading, intra-annotator threading for tasks that can be further decomposed, and remote annotator services which enable annotator scale-out. The scale-up resulted in reducing the average time to process a record from 206 milliseconds to 17 milliseconds or a 12- fold increase in performance when applied to a corpus of 550,000 notes. Purposely simplistic in nature, these scale-up efforts are the straight forward evolution from small scale NLP processing to larger scale extraction without incurring associated complexities that are inherited by the use of the underlying UIMA framework. These efforts represent generalizable and widely applicable techniques that will aid other computationally complex NLP pipelines that are of need to be scaled out for processing and analyzing big data.

  5. Reaction times of moderate and severe stutterers to monaural verbal stimuli: some implications for neurolinguistic organization.

    Science.gov (United States)

    Rastatter, M P; Dell, C W

    1987-03-01

    Fourteen right-handed stutterers and 14 normal speakers (7 men & 7 women) responded to monaurally presented stimuli with their right and left hands. Results of an ANOVA with repeated measures showed that a significant ear-hand interaction existed in the normal subjects' data, with the right-ear, right-hand configuration producing the fastest responses. These findings were in concert with an efficiency model of neurolinguistic organization that suggests that the left hemisphere is dominant for language processing with the right hemisphere being capable of performing less efficient auditory-verbal analysis. Results of a similar ANOVA procedure showed that all main effects and interactions were nonsignificant for the stutterers. From these data a bilateral model of neurolinguistic organization was derived for the stutterers where both hemispheres must participate simultaneously in the decoding process. This held true regardless of sex or severity of stuttering.

  6. Nuclear retention of the transcription factor NLP7 orchestrates the early response to nitrate in plants.

    Science.gov (United States)

    Marchive, Chloé; Roudier, François; Castaings, Loren; Bréhaut, Virginie; Blondet, Eddy; Colot, Vincent; Meyer, Christian; Krapp, Anne

    2013-01-01

    Nitrate is both an important nutrient and a signalling molecule for plants. Although several components of the nitrate signalling pathway have been identified, their hierarchical organization remains unclear. Here we show that the localization of NLP7, a member of the RWP-RK transcription factor family, is regulated by nitrate via a nuclear retention mechanism. Genome-wide analyses revealed that NLP7 binds and modulates a majority of known nitrate signalling and assimilation genes. Our findings indicate that plants, like fungi and mammals, rely on similar nuclear retention mechanisms to instantaneously respond to the availability of key nutrients.

  7. NLP-12 engages different UNC-13 proteins to potentiate tonic and evoked release.

    Science.gov (United States)

    Hu, Zhitao; Vashlishan-Murray, Amy B; Kaplan, Joshua M

    2015-01-21

    A neuropeptide (NLP-12) and its receptor (CKR-2) potentiate tonic and evoked ACh release at Caenorhabditis elegans neuromuscular junctions. Increased evoked release is mediated by a presynaptic pathway (egl-30 Gαq and egl-8 PLCβ) that produces DAG, and by DAG binding to short and long UNC-13 proteins. Potentiation of tonic ACh release persists in mutants deficient for egl-30 Gαq and egl-8 PLCβ and requires DAG binding to UNC-13L (but not UNC-13S). Thus, NLP-12 adjusts tonic and evoked release by distinct mechanisms. Copyright © 2015 the authors 0270-6474/15/351038-05$15.00/0.

  8. Context and comprehension: a neurolinguistic and interactional approach to the understanding of semantic-pragmatic disorder.

    Science.gov (United States)

    Sahlén, B; Nettelbladt, U

    1993-01-01

    In the present study we provide thorough descriptions of two children with a semantic-pragmatic disorder, a subgroup within the group of specific and severe developmental language disorders, from a neurolinguistic and interactional perspective. We argue that the pragmatic problems, at least in these two girls, are most probably secondary to their semantic/conceptual deficit. If sufficient contextual cues are provided comprehension is improved and, as a consequence, the pragmatic problems are reduced.

  9. [Global aphasia. The clinical picture and a consideration of the neurolinguistic structure (author's transl)].

    Science.gov (United States)

    Stachowiak, F J; Huber, W; Kerschensteiner, M; Poeck, K; Weniger, D

    1977-01-13

    Global aphasia is described as a unitary syndrome which is characterized by a severe impairment of all linguistic capabilities. Speech production is extremely limited and consists of stereotyped phrases, recurring utterances or a few isolated words which are usually neologistically distorted. The patients are unable to express their thoughts in a situationally adequate manner. Language comprehension is restricted to simple questions and commands. A clinical description of the syndrome is given and the neurolinguistic structure of the disorders is discussed.

  10. Neurolinguistics and psycholinguistics as a basis for computer acquisition of natural language

    Energy Technology Data Exchange (ETDEWEB)

    Powers, D.M.W.

    1983-04-01

    Research into natural language understanding systems for computers has concentrated on implementing particular grammars and grammatical models of the language concerned. This paper presents a rationale for research into natural language understanding systems based on neurological and psychological principles. Important features of the approach are that it seeks to place the onus of learning the language on the computer, and that it seeks to make use of the vast wealth of relevant psycholinguistic and neurolinguistic theory. 22 references.

  11. DNA-targeted 2-nitroimidazoles: studies of the influence of the phenanthridine-linked nitroimidazoles, 2-NLP-3 and 2-NLP-4, on DNA damage induced by ionizing radiation.

    Science.gov (United States)

    Buchko, Garry W; Weinfeld, Michael

    2002-09-01

    The nitroimidazole-linked phenanthridines 2-NLP-3 (5-[3-(2-nitro-1-imidazoyl)-propyl]-phenanthridinium bromide) and 2-NLP-4 (5-[3-(2-nitro-1-imidazoyl)-butyl]-phenanthridinium bromide) are composed of the radiosensitizer, 2-nitroimidazole, attached to the DNA intercalator phenanthridine by a 3- and 4-carbon linker, respectively. Previous in vitro assays showed both compounds to be 10-100 times more efficient as hypoxic cell radiosensitizers (based on external drug concentrations) than the untargeted 2-nitroimidazole radiosensitizer, misonidazole (Cowan et al., Radiat. Res. 127, 81-89, 1991). Here we have used a (32)P postlabeling assay and 5'-end-labeled oligonucleotide assay to compare the radiation-induced DNA damage generated in the presence of 2-NLP-3, 2-NLP-4, phenanthridine and misonidazole. After irradiation of the DNA under anoxic conditions, we observed a significantly greater level of 3'-phosphoglycolate DNA damage in the presence of 2-NLP-3 or 2-NLP-4 compared to irradiation of the DNA in the presence of misonidazole. This may account at least in part for the greater cellular radiosensitization shown by the nitroimidazole-linked phenanthridines over misonidazole. Of the two nitroimidazole-linked phenanthridines, the better in vitro radiosensitizer, 2-NLP-4, generated more 3'-phosphoglycolate in DNA than did 2-NLP-3. At all concentrations, phenanthridine had little effect on the levels of DNA damage, suggesting that the enhanced radiosensitization displayed by 2-NLP-3 and 2-NLP-4 is due to the localization of the 2-nitroimidazole to the DNA by the phenanthridine substituent and not to radiosensitization by the phenanthridine moiety itself.

  12. Inappropriate Expression of an NLP Effector in Colletotrichum orbiculare Impairs Infection on Cucurbitaceae Cultivars via Plant Recognition of the C-Terminal Region.

    Science.gov (United States)

    Azmi, Nur Sabrina Ahmad; Singkaravanit-Ogawa, Suthitar; Ikeda, Kyoko; Kitakura, Saeko; Inoue, Yoshihiro; Narusaka, Yoshihiro; Shirasu, Ken; Kaido, Masanori; Mise, Kazuyuki; Takano, Yoshitaka

    2018-01-01

    The hemibiotrophic pathogen Colletotrichum orbiculare preferentially expresses a necrosis and ethylene-inducing peptide 1 (Nep1)-like protein named NLP1 during the switch to necrotrophy. Here, we report that the constitutive expression of NLP1 in C. orbiculare blocks pathogen infection in multiple Cucurbitaceae cultivars via their enhanced defense responses. NLP1 has a cytotoxic activity that induces cell death in Nicotiana benthamiana. However, C. orbiculare transgenic lines constitutively expressing a mutant NLP1 lacking the cytotoxic activity still failed to infect cucumber, indicating no clear relationship between cytotoxic activity and the NLP1-dependent enhanced defense. NLP1 also possesses the microbe-associated molecular pattern (MAMP) sequence called nlp24, recognized by Arabidopsis thaliana at its central region, similar to NLPs of other pathogens. Surprisingly, inappropriate expression of a mutant NLP1 lacking the MAMP signature is also effective for blocking pathogen infection, uncoupling the infection block from the corresponding MAMP. Notably, the deletion analyses of NLP1 suggested that the C-terminal region of NLP1 is critical to enhance defense in cucumber. The expression of mCherry fused with the C-terminal 32 amino acids of NLP1 was enough to trigger the defense of cucurbits, revealing that the C-terminal region of the NLP1 protein is recognized by cucurbits and, then, terminates C. orbiculare infection.

  13. CLAM : Quickly deploy NLP command-line tools on the web

    NARCIS (Netherlands)

    van Gompel, M.; Reynaert, M.W.C.

    2014-01-01

    In this paper we present the software CLAM; the Computational Linguistics Application Mediator. CLAM is a tool that allows you to quickly and transparently transform command-line NLP tools into fully-fledged RESTful webservices with which automated clients can communicate, as well as a generic

  14. NATURAL LANGUAGE PROCESSING (NLP UNTUK MENGETAHUI HUKUM BACAAN AL-QUR’AN

    Directory of Open Access Journals (Sweden)

    Heriyanto Heriyanto

    2015-04-01

    Full Text Available Natural Language Processing (NLP to know Al-Quran reading law can analyse text data input in the form of sentence with everyday human being Ianguage of process early by recognizing syntak order and existing production order through scanning, identifying token, result of from token will be conducted by parsing and processed later;then to be conducted by adaptation with existing production order. Result of adaptation will in accepting or is not accepted by if do not fulfill existing production order will emerge message of mistake. The result if as according to order produce hence will present as according to wanted sentence to present Al-Quran reading law. Knowing real correct Al-Quran reading law as according to tartil, its science of its law nya of kifayah fardhu, therefore in studying and knowing Al-Quran reading law by using Natural Language Processing (NLP can fulfill science procedures learn to read Al-Quran matching with tajwid science. NLP which can recognize wanted reading law by consumer for the letter of Al-Fatihah, Al-Baqarah Juz 1. made Application Software can give appearance result of Al-Quran reading laws, NLP which can analyse about wanted reading law with input pass text. Read text pursuant to used production order so that can know reading law which is pursuant to included text

  15. Applications of NLP Techniques to Computer-Assisted Authoring of Test Items for Elementary Chinese

    Science.gov (United States)

    Liu, Chao-Lin; Lin, Jen-Hsiang; Wang, Yu-Chun

    2010-01-01

    The authors report an implemented environment for computer-assisted authoring of test items and provide a brief discussion about the applications of NLP techniques for computer assisted language learning. Test items can serve as a tool for language learners to examine their competence in the target language. The authors apply techniques for…

  16. The Promise of NLP and Speech Processing Technologies in Language Assessment

    Science.gov (United States)

    Chapelle, Carol A.; Chung, Yoo-Ree

    2010-01-01

    Advances in natural language processing (NLP) and automatic speech recognition and processing technologies offer new opportunities for language testing. Despite their potential uses on a range of language test item types, relatively little work has been done in this area, and it is therefore not well understood by test developers, researchers or…

  17. Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans.

    Science.gov (United States)

    Park, Sang-Kyu; Link, Christopher D; Johnson, Thomas E

    2010-02-01

    Recent studies have shown that the rate of aging can be modulated by diverse interventions. Dietary restriction is the most widely used intervention to promote longevity; however, the mechanisms underlying the effect of dietary restriction remain elusive. In a previous study, we identified two novel genes, nlp-7 and cup-4, required for normal longevity in Caenorhabditis elegans. nlp-7 is one of a set of neuropeptide-like protein genes; cup-4 encodes an ion-channel involved in endocytosis by coelomocytes. Here, we assess whether nlp-7 and cup-4 mediate longevity increases by dietary restriction. RNAi of nlp-7 or cup-4 significantly reduces the life span of the eat-2 mutant, a genetic model of dietary restriction, but has no effect on the life span of long-lived mutants resulting from reduced insulin/IGF-1 signaling or dysfunction of the mitochondrial electron transport chain. The life-span extension observed in wild-type N2 worms by dietary restriction using bacterial dilution is prevented significantly in nlp-7 and cup-4 mutants. RNAi knockdown of genes encoding candidate receptors of NLP-7 and genes involved in endocytosis by coelomocytes also specifically shorten the life span of the eat-2 mutant. We conclude that two novel pathways, NLP-7 signaling and endocytosis by coelomocytes, are required for life extension under dietary restriction in C. elegans.

  18. Syndromes of nonfluent primary progressive aphasia: a clinical and neurolinguistic analysis.

    Science.gov (United States)

    Rohrer, Jonathan D; Rossor, Martin N; Warren, Jason D

    2010-08-17

    Despite recent work, the nosology of nonfluent primary progressive aphasia (PPA) remains unresolved. We describe a clinical and neurolinguistic cross-sectional analysis of a cohort of 24 patients with nonfluent PPA. Patients were initially classified based on analysis of spontaneous speech into 4 groups: apraxia of speech (AOS)/agrammatism (10 patients); AOS/no agrammatism (4 patients); no AOS/agrammatism (3 patients); no AOS/no agrammatism (7 patients). These groups were further characterized using a detailed neurolinguistic and neuropsychological battery. Parkinsonism was present in 3/10 patients in the AOS/agrammatism group. All patients in the no AOS/agrammatism group had mutations in the progranulin (GRN) gene, while 5/7 cases in the no AOS/no agrammatism group had CSF findings compatible with Alzheimer disease. The groups without AOS showed more severe neurolinguistic impairments for a given disease stage, and sentence comprehension, speech repetition, and reading were impaired in all groups. Prolonged word-finding pauses and impaired single word comprehension were salient features in the no AOS/agrammatism group. Additional impairments of executive function and praxis were present in both groups with agrammatism, and impaired episodic memory was a feature of the no AOS/no agrammatism group. PPA with AOS is aligned with the syndrome previously designated progressive nonfluent aphasia; agrammatism may emerge as the syndrome evolves, or alternatively, the pure AOS group may be pathophysiologically distinct. PPA without AOS resembles the syndrome designated logopenic/phonologic aphasia; however, there is evidence for a distinct subsyndrome of GRN-associated aphasia. The findings provide a rationale for further longitudinal studies with pathologic correlation.

  19. Neurolinguists, beware! The bilingual is not two monolinguals in one person.

    Science.gov (United States)

    Grosjean, F

    1989-01-01

    Two views of bilingualism are presented--the monolingual or fractional view which holds that the bilingual is (or should be) two monolinguals in one person, and the bilingual or wholistic view which states that the coexistence of two languages in the bilingual has produced a unique and specific speaker-hearer. These views affect how we compare monolinguals and bilinguals, study language learning and language forgetting, and examine the speech modes--monolingual and bilingual--that characterize the bilingual's everyday interactions. The implications of the wholistic view on the neurolinguistics of bilingualism, and in particular bilingual aphasia, are discussed.

  20. Neurolinguistic characteristics of language production in Huntington's disease: a preliminary report.

    Science.gov (United States)

    Gordon, W P; Illes, J

    1987-05-01

    Samples of spontaneous and descriptive speech were obtained from 12 patients with Huntington's disease (HD) and 24 at risk (AR) controls. The data were assessed according to a neurolinguistic protocol. HD was identified with a significant reduction in number of words produced, a diminished level of syntactic complexity, reductions of melodic line, phrase length, articulatory agility, and grammatical form, and increases in paraphasic errors and word-finding difficulty. The data were interpreted in support of the hypothesis that neostriatal pathology affects linguistic processing.

  1. Ground Truth Creation for Complex Clinical NLP Tasks – an Iterative Vetting Approach and Lessons Learned

    Science.gov (United States)

    Liang, Jennifer J.; Tsou, Ching-Huei; Devarakonda, Murthy V.

    2017-01-01

    Natural language processing (NLP) holds the promise of effectively analyzing patient record data to reduce cognitive load on physicians and clinicians in patient care, clinical research, and hospital operations management. A critical need in developing such methods is the “ground truth” dataset needed for training and testing the algorithms. Beyond localizable, relatively simple tasks, ground truth creation is a significant challenge because medical experts, just as physicians in patient care, have to assimilate vast amounts of data in EHR systems. To mitigate potential inaccuracies of the cognitive challenges, we present an iterative vetting approach for creating the ground truth for complex NLP tasks. In this paper, we present the methodology, and report on its use for an automated problem list generation task, its effect on the ground truth quality and system accuracy, and lessons learned from the effort. PMID:28815130

  2. UMLS content views appropriate for NLP processing of the biomedical literature vs. clinical text.

    Science.gov (United States)

    Demner-Fushman, Dina; Mork, James G; Shooshan, Sonya E; Aronson, Alan R

    2010-08-01

    Identification of medical terms in free text is a first step in such Natural Language Processing (NLP) tasks as automatic indexing of biomedical literature and extraction of patients' problem lists from the text of clinical notes. Many tools developed to perform these tasks use biomedical knowledge encoded in the Unified Medical Language System (UMLS) Metathesaurus. We continue our exploration of automatic approaches to creation of subsets (UMLS content views) which can support NLP processing of either the biomedical literature or clinical text. We found that suppression of highly ambiguous terms in the conservative AutoFilter content view can partially replace manual filtering for literature applications, and suppression of two character mappings in the same content view achieves 89.5% precision at 78.6% recall for clinical applications. Published by Elsevier Inc.

  3. The nucleoplasmin homolog NLP mediates centromere clustering and anchoring to the nucleolus.

    Science.gov (United States)

    Padeken, Jan; Mendiburo, María José; Chlamydas, Sarantis; Schwarz, Hans-Jürgen; Kremmer, Elisabeth; Heun, Patrick

    2013-04-25

    Centromere clustering during interphase is a phenomenon known to occur in many different organisms and cell types, yet neither the factors involved nor their physiological relevance is well understood. Using Drosophila tissue culture cells and flies, we identified a network of proteins, including the nucleoplasmin-like protein (NLP), the insulator protein CTCF, and the nucleolus protein Modulo, to be essential for the positioning of centromeres. Artificial targeting further demonstrated that NLP and CTCF are sufficient for clustering, while Modulo serves as the anchor to the nucleolus. Centromere clustering was found to depend on centric chromatin rather than specific DNA sequences. Moreover, unclustering of centromeres results in the spatial destabilization of pericentric heterochromatin organization, leading to partial defects in the silencing of repetitive elements, defects during chromosome segregation, and genome instability. Copyright © 2013 Elsevier Inc. All rights reserved.

  4. Identification of Patients with Family History of Pancreatic Cancer--Investigation of an NLP System Portability.

    Science.gov (United States)

    Mehrabi, Saeed; Krishnan, Anand; Roch, Alexandra M; Schmidt, Heidi; Li, DingCheng; Kesterson, Joe; Beesley, Chris; Dexter, Paul; Schmidt, Max; Palakal, Mathew; Liu, Hongfang

    2015-01-01

    In this study we have developed a rule-based natural language processing (NLP) system to identify patients with family history of pancreatic cancer. The algorithm was developed in a Unstructured Information Management Architecture (UIMA) framework and consisted of section segmentation, relation discovery, and negation detection. The system was evaluated on data from two institutions. The family history identification precision was consistent across the institutions shifting from 88.9% on Indiana University (IU) dataset to 87.8% on Mayo Clinic dataset. Customizing the algorithm on the the Mayo Clinic data, increased its precision to 88.1%. The family member relation discovery achieved precision, recall, and F-measure of 75.3%, 91.6% and 82.6% respectively. Negation detection resulted in precision of 99.1%. The results show that rule-based NLP approaches for specific information extraction tasks are portable across institutions; however customization of the algorithm on the new dataset improves its performance.

  5. Ground Truth Creation for Complex Clinical NLP Tasks - an Iterative Vetting Approach and Lessons Learned.

    Science.gov (United States)

    Liang, Jennifer J; Tsou, Ching-Huei; Devarakonda, Murthy V

    2017-01-01

    Natural language processing (NLP) holds the promise of effectively analyzing patient record data to reduce cognitive load on physicians and clinicians in patient care, clinical research, and hospital operations management. A critical need in developing such methods is the "ground truth" dataset needed for training and testing the algorithms. Beyond localizable, relatively simple tasks, ground truth creation is a significant challenge because medical experts, just as physicians in patient care, have to assimilate vast amounts of data in EHR systems. To mitigate potential inaccuracies of the cognitive challenges, we present an iterative vetting approach for creating the ground truth for complex NLP tasks. In this paper, we present the methodology, and report on its use for an automated problem list generation task, its effect on the ground truth quality and system accuracy, and lessons learned from the effort.

  6. Centrosomal Nlp is an oncogenic protein that is gene-amplified in human tumors and causes spontaneous tumorigenesis in transgenic mice.

    Science.gov (United States)

    Shao, Shujuan; Liu, Rong; Wang, Yang; Song, Yongmei; Zuo, Lihui; Xue, Liyan; Lu, Ning; Hou, Ning; Wang, Mingrong; Yang, Xiao; Zhan, Qimin

    2010-02-01

    Disruption of mitotic events contributes greatly to genomic instability and results in mutator phenotypes. Indeed, abnormalities of mitotic components are closely associated with malignant transformation and tumorigenesis. Here we show that ninein-like protein (Nlp), a recently identified BRCA1-associated centrosomal protein involved in microtubule nucleation and spindle formation, is an oncogenic protein. Nlp was found to be overexpressed in approximately 80% of human breast and lung carcinomas analyzed. In human lung cancers, this deregulated expression was associated with NLP gene amplification. Further analysis revealed that Nlp exhibited strong oncogenic properties; for example, it conferred to NIH3T3 rodent fibroblasts the capacity for anchorage-independent growth in vitro and tumor formation in nude mice. Consistent with these data, transgenic mice overexpressing Nlp displayed spontaneous tumorigenesis in the breast, ovary, and testicle within 60 weeks. In addition, Nlp overexpression induced more rapid onset of radiation-induced lymphoma. Furthermore, mouse embryonic fibroblasts (MEFs) derived from Nlp transgenic mice showed centrosome amplification, suggesting that Nlp overexpression mimics BRCA1 loss. These findings demonstrate that Nlp abnormalities may contribute to genomic instability and tumorigenesis and suggest that Nlp might serve as a potential biomarker for clinical diagnosis and therapeutic target.

  7. A DECADE OF USING HYBRID INFERENCE SYSTEMS IN NLP (2005 – 2015): A SURVEY

    OpenAIRE

    Ali Almiman

    2016-01-01

    In today’s world of digital media, connecting millions of users, large amounts of information is being generated. These are potential mines of knowledge and could give deep insights about the trends of both social and scientific value. However, owing to the fact that most of this is highly unstructured, we cannot make any sense of it. Natural language processing (NLP) is a serious attempt in this direction to organise the textual matter which is in a human understandable form (natural languag...

  8. Reprint of "Does Functional Neuroimaging Solve the Questions of Neurolinguistics?" [Brain and Language 98 (2006) 276-290

    Science.gov (United States)

    Van Lancker Sidtis, Diana

    2007-01-01

    Neurolinguistic research has been engaged in evaluating models of language using measures from brain structure and function, and/or in investigating brain structure and function with respect to language representation using proposed models of language. While the aphasiological strategy, which classifies aphasias based on performance modality and a…

  9. Mapping Partners Master Drug Dictionary to RxNorm using an NLP-based approach.

    Science.gov (United States)

    Zhou, Li; Plasek, Joseph M; Mahoney, Lisa M; Chang, Frank Y; DiMaggio, Dana; Rocha, Roberto A

    2012-08-01

    To develop an automated method based on natural language processing (NLP) to facilitate the creation and maintenance of a mapping between RxNorm and a local medication terminology for interoperability and meaningful use purposes. We mapped 5961 terms from Partners Master Drug Dictionary (MDD) and 99 of the top prescribed medications to RxNorm. The mapping was conducted at both term and concept levels using an NLP tool, called MTERMS, followed by a manual review conducted by domain experts who created a gold standard mapping. The gold standard was used to assess the overall mapping between MDD and RxNorm and evaluate the performance of MTERMS. Overall, 74.7% of MDD terms and 82.8% of the top 99 terms had an exact semantic match to RxNorm. Compared to the gold standard, MTERMS achieved a precision of 99.8% and a recall of 73.9% when mapping all MDD terms, and a precision of 100% and a recall of 72.6% when mapping the top prescribed medications. The challenges and gaps in mapping MDD to RxNorm are mainly due to unique user or application requirements for representing drug concepts and the different modeling approaches inherent in the two terminologies. An automated approach based on NLP followed by human expert review is an efficient and feasible way for conducting dynamic mapping. Copyright © 2011 Elsevier Inc. All rights reserved.

  10. NLP based congestive heart failure case finding: A prospective analysis on statewide electronic medical records.

    Science.gov (United States)

    Wang, Yue; Luo, Jin; Hao, Shiying; Xu, Haihua; Shin, Andrew Young; Jin, Bo; Liu, Rui; Deng, Xiaohong; Wang, Lijuan; Zheng, Le; Zhao, Yifan; Zhu, Chunqing; Hu, Zhongkai; Fu, Changlin; Hao, Yanpeng; Zhao, Yingzhen; Jiang, Yunliang; Dai, Dorothy; Culver, Devore S; Alfreds, Shaun T; Todd, Rogow; Stearns, Frank; Sylvester, Karl G; Widen, Eric; Ling, Xuefeng B

    2015-12-01

    In order to proactively manage congestive heart failure (CHF) patients, an effective CHF case finding algorithm is required to process both structured and unstructured electronic medical records (EMR) to allow complementary and cost-efficient identification of CHF patients. We set to identify CHF cases from both EMR codified and natural language processing (NLP) found cases. Using narrative clinical notes from all Maine Health Information Exchange (HIE) patients, the NLP case finding algorithm was retrospectively (July 1, 2012-June 30, 2013) developed with a random subset of HIE associated facilities, and blind-tested with the remaining facilities. The NLP based method was integrated into a live HIE population exploration system and validated prospectively (July 1, 2013-June 30, 2014). Total of 18,295 codified CHF patients were included in Maine HIE. Among the 253,803 subjects without CHF codings, our case finding algorithm prospectively identified 2411 uncodified CHF cases. The positive predictive value (PPV) is 0.914, and 70.1% of these 2411 cases were found to be with CHF histories in the clinical notes. A CHF case finding algorithm was developed, tested and prospectively validated. The successful integration of the CHF case findings algorithm into the Maine HIE live system is expected to improve the Maine CHF care. Copyright © 2015. Published by Elsevier Ireland Ltd.

  11. An early illness recognition framework using a temporal Smith Waterman algorithm and NLP.

    Science.gov (United States)

    Hajihashemi, Zahra; Popescu, Mihail

    2013-01-01

    In this paper we propose a framework for detecting health patterns based on non-wearable sensor sequence similarity and natural language processing (NLP). In TigerPlace, an aging in place facility from Columbia, MO, we deployed 47 sensor networks together with a nursing electronic health record (EHR) system to provide early illness recognition. The proposed framework utilizes sensor sequence similarity and NLP on EHR nursing comments to automatically notify the physician when health problems are detected. The reported methodology is inspired by genomic sequence annotation using similarity algorithms such as Smith Waterman (SW). Similarly, for each sensor sequence, we associate health concepts extracted from the nursing notes using Metamap, a NLP tool provided by Unified Medical Language System (UMLS). Since sensor sequences, unlike genomics ones, have an associated time dimension we propose a temporal variant of SW (TSW) to account for time. The main challenges presented by our framework are finding the most suitable time sequence similarity and aggregation of the retrieved UMLS concepts. On a pilot dataset from three Tiger Place residents, with a total of 1685 sensor days and 626 nursing records, we obtained an average precision of 0.64 and a recall of 0.37.

  12. Neurolinguistically constrained simulation of sentence comprehension: integrating artificial intelligence and brain theory

    Energy Technology Data Exchange (ETDEWEB)

    Gigley, H.M.

    1982-01-01

    An artificial intelligence approach to the simulation of neurolinguistically constrained processes in sentence comprehension is developed using control strategies for simulation of cooperative computation in associative networks. The desirability of this control strategy in contrast to ATN and production system strategies is explained. A first pass implementation of HOPE, an artificial intelligence simulation model of sentence comprehension, constrained by studies of aphasic performance, psycholinguistics, neurolinguistics, and linguistic theory is described. Claims that the model could serve as a basis for sentence production simulation and for a model of language acquisition as associative learning are discussed. HOPE is a model that performs in a normal state and includes a lesion simulation facility. HOPE is also a research tool. Its modifiability and use as a tool to investigate hypothesized causes of degradation in comprehension performance by aphasic patients are described. Issues of using behavioral constraints in modelling and obtaining appropriate data for simulated process modelling are discussed. Finally, problems of validation of the simulation results are raised; and issues of how to interpret clinical results to define the evolution of the model are discussed. Conclusions with respect to the feasibility of artificial intelligence simulation process modelling are discussed based on the current state of research.

  13. Mõisteid ja meetodeid kaasaegsetes pedagoogilistes süsteemides

    Index Scriptorium Estoniae

    1999-01-01

    Mõistete multiintelligentsus ja NLP - Neuro-Linguistic Programming tähendusest]; emotsionaalne intelligentsus : [mõiste emotsionaalne intelligentsus tähendusest]; konvergentne ja divergentne mõtlemine - inimese mõtlemisprotsessi 2 külge : [mõistete konvergentne ja divergentne mõtlemine tähendusest

  14. A different approach to designing visual displays and workstations

    Energy Technology Data Exchange (ETDEWEB)

    Brown-VanHoozer, S.A.

    1995-06-01

    The material presented in this paper is based on two studies involving the design of visual displays based on the user`s perspective model of a system. The studies involve a methodology known as Neuro-Linguistic Programming (NLP), and its use in expanding design choices from the user`s ``model of the world,`` and the use of virtual reality.

  15. Language in Frontotemporal Dementia: an analysis in light of Enunciative-Discursive Neurolinguistics.

    Science.gov (United States)

    Ucedo, Daniel de Martino; Santos, Karoline Pimentel Dos; Santana, Ana Paula de Oliveira

    2017-08-17

    The aim of this case study was to perform a cross-sectional analysis of spontaneous speech of a patient with Frontotemporal Dementia (FTD). For this purpose, four speech and language therapy episodes, from 2012 to 2014, were selected, transcribed and analyzed in light of Enunciative-Discursive Neurolinguistics. The analysis showed, as the patient's FTD status progressed, that he used different semiotic strategies, e.g., use of repetition and gesture during speech production. It also highlighted the importance of the interlocutor's role of prompting the patient to express verbal meaning. Thus, it can be concluded that the recognition of the strategies used by the patient in favor of his role as a speaker, during interactions, is what enables and legitimates his role.

  16. Neurolinguistic status and localization of lesion in aphasic patients with exclusively consonant-vowel recurring utterances.

    Science.gov (United States)

    Poeck, K; De Bleser, R; von Keyserlingk, D G

    1984-03-01

    Eight patients are presented whose speech production consisted exclusively of one and the same recurring consonant-vowel (CV) syllable, similar to Broca's first patient Leborgne ('Tan-tan'). Their neurolinguistic, aphasiological and localizational status was examined and compared with 32 patients with standard global aphasia and 15 with Broca's aphasia. Patients with exclusively CV speech production represent a variety of global aphasia, characterized by fluency of output and the preservation of some prosody. Localization of the CT lesion did not distinguish between the nonstandard fluent global aphasics described here and the well-known standard nonfluent global aphasics. The individual lesions in both subgroups show great variability in size and localization, which is not recognized in the usual cumulative representations of CT lesions.

  17. [The clinical picture and a consideration of the neurolinguistic structure (author's transl)].

    Science.gov (United States)

    Huber, W; Stachowiak, F J; Poeck, K; Kerschensteiner, M

    1975-09-01

    Despite the variability of its behavioral manifestations Wernicke's aphasia is considered to be a unitary syndrome. According to the criteria of intelligibility, phonemic and semantic paraphasias in spontaneous speech, 4 forms of Wernicke's aphasia are differentiated: 1) with predominantly semantic paraphasias, 2) with semantic jargon, 3) with predominantly phonemic paraphasias and 4) with phonemic jargon. A severe deficit in language understanding is common to all 4 forms. In addition to phonemic and semantic paraphasias paragrammatism is an outstanding feature of the language production in Wernicke's aphasia. After a survey of views about the localization of the lesion and of earlier descriptive models a neurolinguistic explantation of the characteristic symptoms of Wernicke's aphasia is suggested.

  18. A natural language processing program effectively extracts key pathologic findings from radical prostatectomy reports.

    Science.gov (United States)

    Kim, Brian J; Merchant, Madhur; Zheng, Chengyi; Thomas, Anil A; Contreras, Richard; Jacobsen, Steven J; Chien, Gary W

    2014-12-01

    Natural language processing (NLP) software programs have been widely developed to transform complex free text into simplified organized data. Potential applications in the field of medicine include automated report summaries, physician alerts, patient repositories, electronic medical record (EMR) billing, and quality metric reports. Despite these prospects and the recent widespread adoption of EMR, NLP has been relatively underutilized. The objective of this study was to evaluate the performance of an internally developed NLP program in extracting select pathologic findings from radical prostatectomy specimen reports in the EMR. An NLP program was generated by a software engineer to extract key variables from prostatectomy reports in the EMR within our healthcare system, which included the TNM stage, Gleason grade, presence of a tertiary Gleason pattern, histologic subtype, size of dominant tumor nodule, seminal vesicle invasion (SVI), perineural invasion (PNI), angiolymphatic invasion (ALI), extracapsular extension (ECE), and surgical margin status (SMS). The program was validated by comparing NLP results to a gold standard compiled by two blinded manual reviewers for 100 random pathology reports. NLP demonstrated 100% accuracy for identifying the Gleason grade, presence of a tertiary Gleason pattern, SVI, ALI, and ECE. It also demonstrated near-perfect accuracy for extracting histologic subtype (99.0%), PNI (98.9%), TNM stage (98.0%), SMS (97.0%), and dominant tumor size (95.7%). The overall accuracy of NLP was 98.7%. NLP generated a result in report. This novel program demonstrated high accuracy and efficiency identifying key pathologic details from the prostatectomy report within an EMR system. NLP has the potential to assist urologists by summarizing and highlighting relevant information from verbose pathology reports. It may also facilitate future urologic research through the rapid and automated creation of large databases.

  19. Direct transcriptional activation of BT genes by NLP transcription factors is a key component of the nitrate response in Arabidopsis.

    Science.gov (United States)

    Sato, Takeo; Maekawa, Shugo; Konishi, Mineko; Yoshioka, Nozomi; Sasaki, Yuki; Maeda, Haruna; Ishida, Tetsuya; Kato, Yuki; Yamaguchi, Junji; Yanagisawa, Shuichi

    2017-01-29

    Nitrate modulates growth and development, functioning as a nutrient signal in plants. Although many changes in physiological processes in response to nitrate have been well characterized as nitrate responses, the molecular mechanisms underlying the nitrate response are not yet fully understood. Here, we show that NLP transcription factors, which are key regulators of the nitrate response, directly activate the nitrate-inducible expression of BT1 and BT2 encoding putative scaffold proteins with a plant-specific domain structure in Arabidopsis. Interestingly, the 35S promoter-driven expression of BT2 partially rescued growth inhibition caused by reductions in NLP activity in Arabidopsis. Furthermore, simultaneous disruption of BT1 and BT2 affected nitrate-dependent lateral root development. These results suggest that direct activation of BT1 and BT2 by NLP transcriptional activators is a key component of the molecular mechanism underlying the nitrate response in Arabidopsis. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. Mitotic regulator Nlp interacts with XPA/ERCC1 complexes and regulates nucleotide excision repair (NER) in response to UV radiation.

    Science.gov (United States)

    Ma, Xiao-Juan; Shang, Li; Zhang, Wei-Min; Wang, Ming-Rong; Zhan, Qi-Min

    2016-04-10

    Cellular response to DNA damage, including ionizing radiation (IR) and UV radiation, is critical for the maintenance of genomic fidelity. Defects of DNA repair often result in genomic instability and malignant cell transformation. Centrosomal protein Nlp (ninein-like protein) has been characterized as an important cell cycle regulator that is required for proper mitotic progression. In this study, we demonstrate that Nlp is able to improve nucleotide excision repair (NER) activity and protects cells against UV radiation. Upon exposure of cells to UVC, Nlp is translocated into the nucleus. The C-terminus (1030-1382) of Nlp is necessary and sufficient for its nuclear import. Upon UVC radiation, Nlp interacts with XPA and ERCC1, and enhances their association. Interestingly, down-regulated expression of Nlp is found to be associated with human skin cancers, indicating that dysregulated Nlp might be related to the development of human skin cancers. Taken together, this study identifies mitotic protein Nlp as a new and important member of NER pathway and thus provides novel insights into understanding of regulatory machinery involved in NER. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  1. Overview of the gene regulation network and the bacteria biotope tasks in BioNLP'13 shared task.

    OpenAIRE

    Bossy, Robert; Golik, Wiktoria; Ratkovic, Zorana; Valsamou, Dialekti; Bessieres, Philippe; Nédellec, Claire

    2015-01-01

    Informations auteurs : Robert Bossy, Philippe Bessières et Claire NédellecUnité MaIAGE - INRA UR1404 - F-78352 - Jouy-en-Josas - France; International audience; [b]Background[/b]: We present the two Bacteria Track tasks of BioNLP 2013 Shared Task (ST): Gene Regulation Network (GRN) and Bacteria Biotope (BB). These tasks were previously introduced in the 2011 BioNLP-ST Bacteria Track as Bacteria Gene Interaction (BI) and Bacteria Biotope (BB). The Bacteria Track was motivated by a need to deve...

  2. A Description Of Space Relations In An NLP Model: The ABBYY Compreno Approach

    Directory of Open Access Journals (Sweden)

    Aleksey Leontyev

    2015-12-01

    Full Text Available The current paper is devoted to a formal analysis of the space category and, especially, to questions bound with the presentation of space relations in a formal NLP model. The aim is to demonstrate how linguistic and cognitive problems relating to spatial categorization, definition of spatial entities, and the expression of different locative senses in natural languages can be solved in an artificial intelligence system. We offer a description of the locative groups in the ABBYY Compreno formalism – an integral NLP framework applied for machine translation, semantic search, fact extraction, and other tasks based on the semantic analysis of texts. The model is based on a universal semantic hierarchy of the thesaurus type and includes a description of all possible semantic and syntactic links every word can attach. In this work we define the set of semantic locative relations between words, suggest different tools for their syntactic presentation, give formal restrictions for the word classes that can denote spaces, and show different strategies of dealing with locative prepositions, especially as far as the problem of their machine translation is concerned.

  3. Assessment of commercial NLP engines for medication information extraction from dictated clinical notes.

    Science.gov (United States)

    Jagannathan, V; Mullett, Charles J; Arbogast, James G; Halbritter, Kevin A; Yellapragada, Deepthi; Regulapati, Sushmitha; Bandaru, Pavani

    2009-04-01

    We assessed the current state of commercial natural language processing (NLP) engines for their ability to extract medication information from textual clinical documents. Two thousand de-identified discharge summaries and family practice notes were submitted to four commercial NLP engines with the request to extract all medication information. The four sets of returned results were combined to create a comparison standard which was validated against a manual, physician-derived gold standard created from a subset of 100 reports. Once validated, the individual vendor results for medication names, strengths, route, and frequency were compared against this automated standard with precision, recall, and F measures calculated. Compared with the manual, physician-derived gold standard, the automated standard was successful at accurately capturing medication names (F measure=93.2%), but performed less well with strength (85.3%) and route (80.3%), and relatively poorly with dosing frequency (48.3%). Moderate variability was seen in the strengths of the four vendors. The vendors performed better with the structured discharge summaries than with the clinic notes in an analysis comparing the two document types. Although automated extraction may serve as the foundation for a manual review process, it is not ready to automate medication lists without human intervention.

  4. An RLP23-SOBIR1-BAK1 complex mediates NLP-triggered immunity.

    Science.gov (United States)

    Albert, Isabell; Böhm, Hannah; Albert, Markus; Feiler, Christina E; Imkampe, Julia; Wallmeroth, Niklas; Brancato, Caterina; Raaymakers, Tom M; Oome, Stan; Zhang, Heqiao; Krol, Elzbieta; Grefen, Christopher; Gust, Andrea A; Chai, Jijie; Hedrich, Rainer; Van den Ackerveken, Guido; Nürnberger, Thorsten

    2015-10-05

    Plants and animals employ innate immune systems to cope with microbial infection. Pattern-triggered immunity relies on the recognition of microbe-derived patterns by pattern recognition receptors (PRRs). Necrosis and ethylene-inducing peptide 1-like proteins (NLPs) constitute plant immunogenic patterns that are unique, as these proteins are produced by multiple prokaryotic (bacterial) and eukaryotic (fungal, oomycete) species. Here we show that the leucine-rich repeat receptor protein (LRR-RP) RLP23 binds in vivo to a conserved 20-amino-acid fragment found in most NLPs (nlp20), thereby mediating immune activation in Arabidopsis thaliana. RLP23 forms a constitutive, ligand-independent complex with the LRR receptor kinase (LRR-RK) SOBIR1 (Suppressor of Brassinosteroid insensitive 1 (BRI1)-associated kinase (BAK1)-interacting receptor kinase 1), and recruits a second LRR-RK, BAK1, into a tripartite complex upon ligand binding. Stable, ectopic expression of RLP23 in potato (Solanum tuberosum) confers nlp20 pattern recognition and enhanced immunity to destructive oomycete and fungal plant pathogens, such as Phytophthora infestans and Sclerotinia sclerotiorum. PRRs that recognize widespread microbial patterns might be particularly suited for engineering immunity in crop plants.

  5. A generalizable NLP framework for fast development of pattern-based biomedical relation extraction systems.

    Science.gov (United States)

    Peng, Yifan; Torii, Manabu; Wu, Cathy H; Vijay-Shanker, K

    2014-08-23

    Text mining is increasingly used in the biomedical domain because of its ability to automatically gather information from large amount of scientific articles. One important task in biomedical text mining is relation extraction, which aims to identify designated relations among biological entities reported in literature. A relation extraction system achieving high performance is expensive to develop because of the substantial time and effort required for its design and implementation. Here, we report a novel framework to facilitate the development of a pattern-based biomedical relation extraction system. It has several unique design features: (1) leveraging syntactic variations possible in a language and automatically generating extraction patterns in a systematic manner, (2) applying sentence simplification to improve the coverage of extraction patterns, and (3) identifying referential relations between a syntactic argument of a predicate and the actual target expected in the relation extraction task. A relation extraction system derived using the proposed framework achieved overall F-scores of 72.66% for the Simple events and 55.57% for the Binding events on the BioNLP-ST 2011 GE test set, comparing favorably with the top performing systems that participated in the BioNLP-ST 2011 GE task. We obtained similar results on the BioNLP-ST 2013 GE test set (80.07% and 60.58%, respectively). We conducted additional experiments on the training and development sets to provide a more detailed analysis of the system and its individual modules. This analysis indicates that without increasing the number of patterns, simplification and referential relation linking play a key role in the effective extraction of biomedical relations. In this paper, we present a novel framework for fast development of relation extraction systems. The framework requires only a list of triggers as input, and does not need information from an annotated corpus. Thus, we reduce the involvement of domain

  6. Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome.

    Science.gov (United States)

    Casenghi, Martina; Barr, Francis A; Nigg, Erich A

    2005-11-01

    When cells enter mitosis the microtubule (MT) network undergoes a profound rearrangement, in part due to alterations in the MT nucleating and anchoring properties of the centrosome. Ninein and the ninein-like protein (Nlp) are centrosomal proteins involved in MT organisation in interphase cells. We show that the overexpression of these two proteins induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery. The ability of Nlp and ninein to perturb the cytoplasmic distribution of these organelles depends on their ability to interact with the dynein-dynactin motor complex. Our data also indicate that dynactin is required for the targeting of Nlp and ninein to the centrosome. Furthermore, phosphorylation of Nlp by the polo-like kinase 1 (Plk1) negatively regulates its association with dynactin. These findings uncover a mechanism through which Plk1 helps to coordinate changes in MT organisation with cell cycle progression, by controlling the dynein-dynactin-dependent transport of centrosomal proteins.

  7. Overview of the gene regulation network and the bacteria biotope tasks in BioNLP'13 shared task.

    Science.gov (United States)

    Bossy, Robert; Golik, Wiktoria; Ratkovic, Zorana; Valsamou, Dialekti; Bessières, Philippe; Nédellec, Claire

    2015-01-01

    We present the two Bacteria Track tasks of BioNLP 2013 Shared Task (ST): Gene Regulation Network (GRN) and Bacteria Biotope (BB). These tasks were previously introduced in the 2011 BioNLP-ST Bacteria Track as Bacteria Gene Interaction (BI) and Bacteria Biotope (BB). The Bacteria Track was motivated by a need to develop specific BioNLP tools for fine-grained event extraction in bacteria biology. The 2013 tasks expand on the 2011 version by better addressing the biological knowledge modeling needs. New evaluation metrics were designed for the new goals. Moving beyond a list of gene interactions, the goal of the GRN task is to build a gene regulation network from the extracted gene interactions. BB'13 is dedicated to the extraction of bacteria biotopes, i.e. bacterial environmental information, as was BB'11. BB'13 extends the typology of BB'11 to a large diversity of biotopes, as defined by the OntoBiotope ontology. The detection of entities and events is tackled by distinct subtasks in order to measure the progress achieved by the participant systems since 2011. This paper details the corpus preparations and the evaluation metrics, as well as summarizing and discussing the participant results. Five groups participated in each of the two tasks. The high diversity of the participant methods reflects the dynamism of the BioNLP research community. The evaluation results suggest new research directions for the improvement and development of Information Extraction for molecular and environmental biology. The Bacteria Track tasks remain publicly open; the BioNLP-ST website provides an online evaluation service, the reference corpora and the evaluation tools.

  8. Tailoring vocabularies for NLP in sub-domains: a method to detect unused word sense.

    Science.gov (United States)

    Figueroa, Rosa L; Zeng-Treitler, Qing; Goryachev, Sergey; Wiechmann, Eduardo P

    2009-11-14

    We developed a method to help tailor a comprehensive vocabulary system (e.g. the UMLS) for a sub-domain (e.g. clinical reports) in support of natural language processing (NLP). The method detects unused sense in a sub-domain by comparing the relational neighborhood of a word/term in the vocabulary with the semantic neighborhood of the word/term in the sub-domain. The semantic neighborhood of the word/term in the sub-domain is determined using latent semantic analysis (LSA). We trained and tested the unused sense detection on two clinical text corpora: one contains discharge summaries and the other outpatient visit notes. We were able to detect unused senses with precision from 79% to 87%, recall from 48% to 74%, and an area under receiver operation curve (AUC) of 72% to 87%.

  9. NLP-PIER: A Scalable Natural Language Processing, Indexing, and Searching Architecture for Clinical Notes.

    Science.gov (United States)

    McEwan, Reed; Melton, Genevieve B; Knoll, Benjamin C; Wang, Yan; Hultman, Gretchen; Dale, Justin L; Meyer, Tim; Pakhomov, Serguei V

    2016-01-01

    Many design considerations must be addressed in order to provide researchers with full text and semantic search of unstructured healthcare data such as clinical notes and reports. Institutions looking at providing this functionality must also address the big data aspects of their unstructured corpora. Because these systems are complex and demand a non-trivial investment, there is an incentive to make the system capable of servicing future needs as well, further complicating the design. We present architectural best practices as lessons learned in the design and implementation NLP-PIER (Patient Information Extraction for Research), a scalable, extensible, and secure system for processing, indexing, and searching clinical notes at the University of Minnesota.

  10. Using NLP to identify cancer cases in imaging reports drawn from radiology information systems.

    Science.gov (United States)

    Patrick, Jon; Asgari, Pooyan; Li, Min; Nguyen, Dung

    2013-01-01

    A Natural Language processing (NLP) classifier has been developed for the Victorian and NSW Cancer Registries with the purpose of automatically identifying cancer reports from imaging services, transmitting them to the Registries and then extracting pertinent cancer information. Large scale trials conducted on over 40,000 reports show the sensitivity for identifying reportable cancer reports is above 98% with a specificity above 96%. Detection of tumour stream, report purpose, and a variety of extracted content is generally above 90% specificity. The differences between report layout and authoring strategies across imaging services appear to require different classifiers to retain this high level of accuracy. Linkage of the imaging data with existing registry records (hospital and pathology reports) to derive stage and recurrence of cancer has commenced and shown very promising results.

  11. Overexpression of Arabidopsis NLP7 improves plant growth under both nitrogen-limiting and -sufficient conditions by enhancing nitrogen and carbon assimilation

    Science.gov (United States)

    Yu, Lin-Hui; Wu, Jie; Tang, Hui; Yuan, Yang; Wang, Shi-Mei; Wang, Yu-Ping; Zhu, Qi-Sheng; Li, Shi-Gui; Xiang, Cheng-Bin

    2016-01-01

    Nitrogen is essential for plant survival and growth. Excessive application of nitrogenous fertilizer has generated serious environment pollution and increased production cost in agriculture. To deal with this problem, tremendous efforts have been invested worldwide to increase the nitrogen use ability of crops. However, only limited success has been achieved to date. Here we report that NLP7 (NIN-LIKE PROTEIN 7) is a potential candidate to improve plant nitrogen use ability. When overexpressed in Arabidopsis, NLP7 increases plant biomass under both nitrogen-poor and -rich conditions with better-developed root system and reduced shoot/root ratio. NLP7–overexpressing plants show a significant increase in key nitrogen metabolites, nitrogen uptake, total nitrogen content, and expression levels of genes involved in nitrogen assimilation and signalling. More importantly, overexpression of NLP7 also enhances photosynthesis rate and carbon assimilation, whereas knockout of NLP7 impaired both nitrogen and carbon assimilation. In addition, NLP7 improves plant growth and nitrogen use in transgenic tobacco (Nicotiana tabacum). Our results demonstrate that NLP7 significantly improves plant growth under both nitrogen-poor and -rich conditions by coordinately enhancing nitrogen and carbon assimilation and sheds light on crop improvement. PMID:27293103

  12. Neurolinguistic and follow-up study of an unusual pattern of recovery from bilingual subcortical aphasia.

    Science.gov (United States)

    Aglioti, S; Beltramello, A; Girardi, F; Fabbro, F

    1996-10-01

    We report on the neuropsychological and neurolinguistic features of a bilingual patient, E.M., who presented with an uncommon pattern of aphasic deficit consequent to subcortical lesions mainly involving the left basal ganglia. Not only are reports of bilingual subcortical aphasia rare, but E.M.'s deficit is particularly uncommon for it concerns the most used mother tongue (Venetian) much more than a less practiced second language (standard Italian). In this patient, the linguistic deficit in mother tongue production has been observed in spontaneous speech and in cross language translation tasks, where an asymmetrical paradoxical performance has been revealed. Indeed, unlike neurologically intact subjects, E.M. has more difficulties when translating into her mother tongue than into her second language. Although E.M.'s mother tongue is prevalently an oral language, the asymmetrical translation pattern is similar in written and oral translation tasks, thus ruling out the possibility that the deficit simply reflects differences between written and oral language codes. Finally, another remarkable feature of E.M.'s impairment is its stability over almost 5 years from the stroke. We propose that this unusual type of recovery in E.M. is related to the higher degree of automatization of the first language with respect to the second one. This proposal fits with the role of basal ganglia in automatized motor and cognitive performance.

  13. [Neurolinguistic features during recovery of a Chinese patient with pure alexia].

    Science.gov (United States)

    Chen, Chen; Liu, Xiaojia; Pan, Suyue; Wu, Xiaoqin; Wu, Jibao

    2013-05-01

    To analyze the neurolinguistic features of a Chinese patient with pure alexia in acute and convalescent stages. We assessed the reading and writing abilities of the patient with the Aphasia Battery of Chinese (ABC), the reading examination of Chinese characters (1999, Lin) and the Chinese agraphia battery (CAB). In the ABC examination in the acute phase, the patient performed well in oral expression and comprehension, and the prominent linguistic abnormalities were alexia and merging agraphia; in the convalescent phase, the recovery of alexia was better than that of agraphia. In reading examination of Chinese characters, shape errors were the main reading disorders in the acute phase with a few semantic errors, regularization errors and mistakes in pronunciation, but only shape errors reappeared in the recovery period. CAB examination showed impairment of writing for pictures and dictation abilities in the recovery period but recovery of other writing abilities. The writing disorder was manifested as aphasic agraphia, with obvious dysorthography and lexical errors; the patient was capable of spontaneous writing only after spontaneous speech, and was able to read the written words. The linguistic components of the Chinese patient with pure alexia showed different patterns of damage and recovery, suggesting the difference in their respective neuropsychological pathways.

  14. Neurolinguistic features of spontaneous language production dissociate three forms of neurodegenerative disease: Alzheimer's, Huntington's, and Parkinson's.

    Science.gov (United States)

    Illes, J

    1989-11-01

    An analysis of the temporal (prospective) form (silent and filled hesitations, repetitions, incomplete phrases, context-related comments, interjections), syntactic form, and lexical (retrospective) form (verbal deviations, open and closed class phrases) of spontaneous language production of early and middle stage Alzheimer's, Huntington's, and Parkinson's patients was made. Results showed that the language structure was disrupted in each disease, but in different ways. Temporal interruptions of varying types were frequent in the language of Alzheimer's and Huntington's Disease patients; only long-duration silent hesitations were frequent in Parkinson's language samples. Syntactic complexity was reduced in Huntington's Disease. Verbal paraphasias were found in both the language of Alzheimer's patients, as well as moderately advanced Huntington's patients. Closed class phrases were predominant in the language of Alzheimer's patients and Huntington's patients, and open class phrases in the language of Parkinson's patients. Taken together, the results suggest that (1) there is a unique neurolinguistic profile for spontaneous language production for each neurodegenerative disease, (2) pathology of the neostriatum disrupts syntactic organization, (3) adaptive strategies are used to cope with verbal and speech-motor difficulties, and (4) adaptive strategies fail to be effective with increasing disease severity.

  15. PLENATITUDE Teacher Education for Effectiveness and Well-Being with Neuro-Linguistic Programming

    Science.gov (United States)

    Vieira, Cristina Rocha; Gaspar, Maria Filomena

    2013-01-01

    The role and functioning of schools are changing as well as what is expected of teachers (who face growing and diversified challenges); consequentially, well-being at the schools is endangered. As teachers and teachers' educators concern is: How to improve schools' and teachers' effectiveness and promote well-being. Believing that the path to…

  16. Test of the neurolinguistic programming hypothesis that eye-movements relate to processing imagery.

    Science.gov (United States)

    Wertheim, E H; Habib, C; Cumming, G

    1986-04-01

    Bandler and Grinder's hypothesis that eye-movements reflect sensory processing was examined. 28 volunteers first memorized and then recalled visual, auditory, and kinesthetic stimuli. Changes in eye-positions during recall were videotaped and categorized by two raters into positions hypothesized by Bandler and Grinder's model to represent visual, auditory, and kinesthetic recall. Planned contrast analyses suggested that visual stimulus items, when recalled, elicited significantly more upward eye-positions and stares than auditory and kinesthetic items. Auditory and kinesthetic items, however, did not elicit more changes in eye-position hypothesized by the model to represent auditory and kinesthetic recall, respectively.

  17. Mental Imagery as Revealed by Eye Movements and Spoken Predicates: A Test of Neurolinguistic Programming.

    Science.gov (United States)

    Elich, Matthew; And Others

    1985-01-01

    Tested Bandler and Grinder's proposal that eye movement direction and spoken predicates are indicative of sensory modality of imagery. Subjects reported images in the three modes, but no relation between imagery and eye movements or predicates was found. Visual images were most vivid and often reported. Most subjects rated themselves as visual,…

  18. Neurolinguistic Programming: The Impact of Imagery Tasks on Sensory Predicate Usage.

    Science.gov (United States)

    Graunke, Bruce; Roberts, T. Kevin

    1985-01-01

    Investigated the impact of varied imagining tasks on individuals' use of sensory predicates. Results demonstrated that subjects were able to vary their type of sensory predicates according to the task demands or situational context. Findings are incongruent with Bandler and Grinder's (1979) conceptualization of representational systems.…

  19. Application of Neurolinguistic Programming for Treatment and Relapse Prevention of Addictive Behaviors.

    Science.gov (United States)

    Sandhu, Daya Singh

    The dilemma of relapse exists for a number of addictive behaviors, and mental health authorities agree that keeping addictive behaviors off permanently is much more difficult than treating the behaviors initially. Several relapse prevention models have been posited and environmental, physiological, behavioral, cognitive, and affective factors have…

  20. Insights into Substrate Specificity of NlpC/P60 Cell Wall Hydrolases Containing Bacterial SH3 Domains

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Qingping; Mengin-Lecreulx, Dominique; Liu, Xueqian W.; Patin, Delphine; Farr, Carol L.; Grant, Joanna C.; Chiu, Hsiu-Ju; Jaroszewski, Lukasz; Knuth, Mark W.; Godzik, Adam; Lesley, Scott A.; Elsliger, Marc-André; Deacon, Ashley M.; Wilson, Ian A.

    2015-09-15

    ABSTRACT

    Bacterial SH3 (SH3b) domains are commonly fused with papain-like Nlp/P60 cell wall hydrolase domains. To understand how the modular architecture of SH3b and NlpC/P60 affects the activity of the catalytic domain, three putative NlpC/P60 cell wall hydrolases were biochemically and structurally characterized. These enzymes all have γ-d-Glu-A2pm (A2pm is diaminopimelic acid) cysteine amidase (ordl-endopeptidase) activities but with different substrate specificities. One enzyme is a cell wall lysin that cleaves peptidoglycan (PG), while the other two are cell wall recycling enzymes that only cleave stem peptides with an N-terminall-Ala. Their crystal structures revealed a highly conserved structure consisting of two SH3b domains and a C-terminal NlpC/P60 catalytic domain, despite very low sequence identity. Interestingly, loops from the first SH3b domain dock into the ends of the active site groove of the catalytic domain, remodel the substrate binding site, and modulate substrate specificity. Two amino acid differences at the domain interface alter the substrate binding specificity in favor of stem peptides in recycling enzymes, whereas the SH3b domain may extend the peptidoglycan binding surface in the cell wall lysins. Remarkably, the cell wall lysin can be converted into a recycling enzyme with a single mutation.

    IMPORTANCEPeptidoglycan is a meshlike polymer that envelops the bacterial plasma membrane and bestows structural integrity. Cell wall lysins and recycling enzymes are part of a set of lytic enzymes that target covalent bonds connecting the amino acid and amino sugar building blocks of the PG network. These hydrolases are involved in processes such as cell growth and division, autolysis, invasion, and PG turnover and recycling. To avoid cleavage of unintended substrates, these enzymes have very selective substrate specificities. Our biochemical and structural

  1. A Sibling-Mediated Intervention for Children with Autism Spectrum Disorder: Using the Natural Language Paradigm (NLP).

    Science.gov (United States)

    Spector, Vicki; Charlop, Marjorie H

    2017-11-23

    We taught three typically developing siblings to occasion speech by implementing the Natural Language Paradigm (NLP) with their brothers with autism spectrum disorder (ASD). A non-concurrent multiple baseline design across children with ASD and sibling dyads was used. Ancillary behaviors of happiness, play, and joint attention for the children with ASD were recorded. Generalization of speech for the children with ASD across setting and peers was also measured. During baseline, the children with ASD displayed few target speech behaviors and the siblings inconsistently occasioned speech from their brothers. After sibling training, however, they successfully delivered NLP, and in turn, for two of the brothers with ASD, speech reached criterion. Implications of this research suggest the inclusion of siblings in interventions.

  2. Comparing ICD9-encoded diagnoses and NLP-processed discharge summaries for clinical trials pre-screening: a case study.

    Science.gov (United States)

    Li, Li; Chase, Herbert S; Patel, Chintan O; Friedman, Carol; Weng, Chunhua

    2008-11-06

    The prevalence of electronic medical record (EMR) systems has made mass-screening for clinical trials viable through secondary uses of clinical data, which often exist in both structured and free text formats. The tradeoffs of using information in either data format for clinical trials screening are understudied. This paper compares the results of clinical trial eligibility queries over ICD9-encoded diagnoses and NLP-processed textual discharge summaries. The strengths and weaknesses of both data sources are summarized along the following dimensions: information completeness, expressiveness, code granularity, and accuracy of temporal information. We conclude that NLP-processed patient reports supplement important information for eligibility screening and should be used in combination with structured data.

  3. Overview of the ID, EPI and REL tasks of BioNLP Shared Task 2011

    Directory of Open Access Journals (Sweden)

    Pyysalo Sampo

    2012-06-01

    Full Text Available Abstract We present the preparation, resources, results and analysis of three tasks of the BioNLP Shared Task 2011: the main tasks on Infectious Diseases (ID and Epigenetics and Post-translational Modifications (EPI, and the supporting task on Entity Relations (REL. The two main tasks represent extensions of the event extraction model introduced in the BioNLP Shared Task 2009 (ST'09 to two new areas of biomedical scientific literature, each motivated by the needs of specific biocuration tasks. The ID task concerns the molecular mechanisms of infection, virulence and resistance, focusing in particular on the functions of a class of signaling systems that are ubiquitous in bacteria. The EPI task is dedicated to the extraction of statements regarding chemical modifications of DNA and proteins, with particular emphasis on changes relating to the epigenetic control of gene expression. By contrast to these two application-oriented main tasks, the REL task seeks to support extraction in general by separating challenges relating to part-of relations into a subproblem that can be addressed by independent systems. Seven groups participated in each of the two main tasks and four groups in the supporting task. The participating systems indicated advances in the capability of event extraction methods and demonstrated generalization in many aspects: from abstracts to full texts, from previously considered subdomains to new ones, and from the ST'09 extraction targets to other entities and events. The highest performance achieved in the supporting task REL, 58% F-score, is broadly comparable with levels reported for other relation extraction tasks. For the ID task, the highest-performing system achieved 56% F-score, comparable to the state-of-the-art performance at the established ST'09 task. In the EPI task, the best result was 53% F-score for the full set of extraction targets and 69% F-score for a reduced set of core extraction targets, approaching a level

  4. Toward a Learning Health-care System - Knowledge Delivery at the Point of Care Empowered by Big Data and NLP.

    Science.gov (United States)

    Kaggal, Vinod C; Elayavilli, Ravikumar Komandur; Mehrabi, Saeed; Pankratz, Joshua J; Sohn, Sunghwan; Wang, Yanshan; Li, Dingcheng; Rastegar, Majid Mojarad; Murphy, Sean P; Ross, Jason L; Chaudhry, Rajeev; Buntrock, James D; Liu, Hongfang

    2016-01-01

    The concept of optimizing health care by understanding and generating knowledge from previous evidence, ie, the Learning Health-care System (LHS), has gained momentum and now has national prominence. Meanwhile, the rapid adoption of electronic health records (EHRs) enables the data collection required to form the basis for facilitating LHS. A prerequisite for using EHR data within the LHS is an infrastructure that enables access to EHR data longitudinally for health-care analytics and real time for knowledge delivery. Additionally, significant clinical information is embedded in the free text, making natural language processing (NLP) an essential component in implementing an LHS. Herein, we share our institutional implementation of a big data-empowered clinical NLP infrastructure, which not only enables health-care analytics but also has real-time NLP processing capability. The infrastructure has been utilized for multiple institutional projects including the MayoExpertAdvisor, an individualized care recommendation solution for clinical care. We compared the advantages of big data over two other environments. Big data infrastructure significantly outperformed other infrastructure in terms of computing speed, demonstrating its value in making the LHS a possibility in the near future.

  5. FIRST AND SECOND LANGUAGE DEVELOPMENT IN YOUNG CHILDREN AND BILINGUALISM IN LIGHT OF LINGUISTICS, NEUROLINGUISTICS AND FINDINGS FROM BRAIN RESEARCH

    Directory of Open Access Journals (Sweden)

    Yunus PINAR

    2015-10-01

    Full Text Available The present review shows that infants begin picking up elements of what will be their first language in the womb, and certainly long before their first coo according to the current guidelines and it presents a descriptive approach to bilingualism and multilingualism. This article is the outcome of a thorough survey of literature and primarily it aims to present the similarities and differences between the L1 and L2 acquisition in light of linguistics, neurolinguistics and findings from brain research. This Review will illustrate various thought and new hypotheses on first and second language development, bilingualism and multilingualism derived from studies in linguistics, neurolinguistics and brain research. In the context of our paper we shall try to describe aspects and stages of first language acquisition from even before birth especially the 20th week of the fetal development of the baby to 60th week of life, as well as the second language acquisition process, which is divided into three types: simultaneous, consecutive and adult. In particular, we will present and discuss some of the main results of the brain researchers like Franceschini and De Bleser and we shall interpret them.

  6. ONTOLOGY EXTRACTION FOR AGRICULTURE DOMAIN IN MARATHI LANGUAGE USING NLP TECHNIQUES

    Directory of Open Access Journals (Sweden)

    Prachi Dalvi

    2016-10-01

    Full Text Available Ontology is defined as shared specification of conceptual vocabulary used for formulating knowledge-level theories about a domain of discourse. Dataset is created by manually collecting information about different diseases related to crops. Ontology modeling is used for knowledge representation of various domains. India is an agricultural based economic country. Majority of Indian population relies on farming but the technologies are sparsely used for the aid of farmers. Ontology based modeling for agricultural knowledge can change this scenario. The farmers can understand it easily in their native language. We proposed a system which will model and extract knowledge in Marathi language. In this paper, we review various existing agriculture ontology’s along with some of Natural Language Processing (NLP models. Model ontology for agriculture domain system aims to retrieve relevant answers to the farmer’s query. We explored Rule-Based and Conditional Random Fields based models for Ontology extraction. The extraction methods and preprocessing phases of proposed system is discussed.

  7. Synthesis and characterization of Her2-NLP peptide conjugates targeting circulating breast cancer cells: cellular uptake and localization by fluorescent microscopic imaging.

    Science.gov (United States)

    Cai, Huawei; Singh, Ajay N; Sun, Xiankai; Peng, Fangyu

    2015-01-01

    To synthesize a fluorescent Her2-NLP peptide conjugate consisting of Her2/neu targeting peptide and nuclear localization sequence peptide (NLP) and assess its cellular uptake and intracellular localization for radionuclide cancer therapy targeting Her2/neu-positive circulating breast cancer cells (CBCC). Fluorescent Cy5.5 Her2-NLP peptide conjugate was synthesized by coupling a bivalent peptide sequence, which consisted of a Her2-binding peptide (NH2-GSGKCCYSL) and an NLP peptide (CGYGPKKKRKVGG) linked by a polyethylene glycol (PEG) chain with 6 repeating units, with an activated Cy5.5 ester. The conjugate was separated and purified by HPLC and then characterized by Maldi-MS. The intracellular localization of fluorescent Cy5.5 Her2-NLP peptide conjugate was assessed by fluorescent microscopic imaging using a confocal microscope after incubation of Cy5.5-Her2-NLP with Her2/neu positive breast cancer cells and Her2/neu negative control breast cancer cells, respectively. Fluorescent signals were detected in cytoplasm of Her2/neu positive breast cancer cells (SKBR-3 and BT474 cell lines), but not or little in cytoplasm of Her2/neu negative breast cancer cells (MDA-MB-231), after incubation of the breast cancer cells with Cy5.5-Her2-NLP conjugates in vitro. No fluorescent signals were detected within the nuclei of Her2/neu positive SKBR-3 and BT474 breast cancer cells, neither Her2/neu negative MDA-MB-231 cells, incubated with the Cy5.5-Her2-NLP peptide conjugates, suggesting poor nuclear localization of the Cy5.5-Her2-NLP conjugates localized within the cytoplasm after their cellular uptake and internalization by the Her2/neu positive breast cancer cells. Her2-binding peptide (KCCYSL) is a promising agent for radionuclide therapy of Her2/neu positive breast cancer using a β(-) or α emitting radionuclide, but poor nuclear localization of the Her2-NLP peptide conjugates may limit its use for eradication of Her2/neu-positive CBCC using I-125 or other Auger electron

  8. Event extraction of bacteria biotopes: a knowledge-intensive NLP-based approach.

    Science.gov (United States)

    Ratkovic, Zorana; Golik, Wiktoria; Warnier, Pierre

    2012-06-26

    Bacteria biotopes cover a wide range of diverse habitats including animal and plant hosts, natural, medical and industrial environments. The high volume of publications in the microbiology domain provides a rich source of up-to-date information on bacteria biotopes. This information, as found in scientific articles, is expressed in natural language and is rarely available in a structured format, such as a database. This information is of great importance for fundamental research and microbiology applications (e.g., medicine, agronomy, food, bioenergy). The automatic extraction of this information from texts will provide a great benefit to the field. We present a new method for extracting relationships between bacteria and their locations using the Alvis framework. Recognition of bacteria and their locations was achieved using a pattern-based approach and domain lexical resources. For the detection of environment locations, we propose a new approach that combines lexical information and the syntactic-semantic analysis of corpus terms to overcome the incompleteness of lexical resources. Bacteria location relations extend over sentence borders, and we developed domain-specific rules for dealing with bacteria anaphors. We participated in the BioNLP 2011 Bacteria Biotope (BB) task with the Alvis system. Official evaluation results show that it achieves the best performance of participating systems. New developments since then have increased the F-score by 4.1 points. We have shown that the combination of semantic analysis and domain-adapted resources is both effective and efficient for event information extraction in the bacteria biotope domain. We plan to adapt the method to deal with a larger set of location types and a large-scale scientific article corpus to enable microbiologists to integrate and use the extracted knowledge in combination with experimental data.

  9. Novel Use of Natural Language Processing (NLP to Predict Suicidal Ideation and Psychiatric Symptoms in a Text-Based Mental Health Intervention in Madrid

    Directory of Open Access Journals (Sweden)

    Benjamin L. Cook

    2016-01-01

    Full Text Available Natural language processing (NLP and machine learning were used to predict suicidal ideation and heightened psychiatric symptoms among adults recently discharged from psychiatric inpatient or emergency room settings in Madrid, Spain. Participants responded to structured mental and physical health instruments at multiple follow-up points. Outcome variables of interest were suicidal ideation and psychiatric symptoms (GHQ-12. Predictor variables included structured items (e.g., relating to sleep and well-being and responses to one unstructured question, “how do you feel today?” We compared NLP-based models using the unstructured question with logistic regression prediction models using structured data. The PPV, sensitivity, and specificity for NLP-based models of suicidal ideation were 0.61, 0.56, and 0.57, respectively, compared to 0.73, 0.76, and 0.62 of structured data-based models. The PPV, sensitivity, and specificity for NLP-based models of heightened psychiatric symptoms (GHQ-12 ≥ 4 were 0.56, 0.59, and 0.60, respectively, compared to 0.79, 0.79, and 0.85 in structured models. NLP-based models were able to generate relatively high predictive values based solely on responses to a simple general mood question. These models have promise for rapidly identifying persons at risk of suicide or psychological distress and could provide a low-cost screening alternative in settings where lengthy structured item surveys are not feasible.

  10. Novel Use of Natural Language Processing (NLP) to Predict Suicidal Ideation and Psychiatric Symptoms in a Text-Based Mental Health Intervention in Madrid.

    Science.gov (United States)

    Cook, Benjamin L; Progovac, Ana M; Chen, Pei; Mullin, Brian; Hou, Sherry; Baca-Garcia, Enrique

    2016-01-01

    Natural language processing (NLP) and machine learning were used to predict suicidal ideation and heightened psychiatric symptoms among adults recently discharged from psychiatric inpatient or emergency room settings in Madrid, Spain. Participants responded to structured mental and physical health instruments at multiple follow-up points. Outcome variables of interest were suicidal ideation and psychiatric symptoms (GHQ-12). Predictor variables included structured items (e.g., relating to sleep and well-being) and responses to one unstructured question, "how do you feel today?" We compared NLP-based models using the unstructured question with logistic regression prediction models using structured data. The PPV, sensitivity, and specificity for NLP-based models of suicidal ideation were 0.61, 0.56, and 0.57, respectively, compared to 0.73, 0.76, and 0.62 of structured data-based models. The PPV, sensitivity, and specificity for NLP-based models of heightened psychiatric symptoms (GHQ-12 ≥ 4) were 0.56, 0.59, and 0.60, respectively, compared to 0.79, 0.79, and 0.85 in structured models. NLP-based models were able to generate relatively high predictive values based solely on responses to a simple general mood question. These models have promise for rapidly identifying persons at risk of suicide or psychological distress and could provide a low-cost screening alternative in settings where lengthy structured item surveys are not feasible.

  11. Neurolinguistic analysis of the language abilities of a patient with a "double disconnection syndrome": a case of subangular alexia in the presence of mixed transcortical aphasia.

    Science.gov (United States)

    Pirozzolo, F J; Kerr, K L; Obrzut, J E; Morley, G K; Haxby, J V; Lundgren, S

    1981-01-01

    In contrast to the classic form of alexia without agraphia, subangular alexia results from a single lesion located deep in the white matter of the left parietal lobe. In the present report, a patient with subangular alexia and features of mixed transcortical aphasia is described. Neurolinguistic findings include: alexia without agraphia, paucity of spontaneous speech, moderate auditory comprehension difficulty, excellent repetition, echopraxia, colour agnosia, and naming disorder. Neurolinguistic tests revealed intact phonological organisation and grammatical filter." Our studies revealed a "double disconnection syndrome," the co-existence of two relatively rare neurobehavioural disorders. Furthermore, the studies reported here clearly show dissociations of language functions in both the visual and auditory modality, which demonstrates that the stages of language processing are separable. Images PMID:7217972

  12. Neurolinguistic analysis of the language abilities of a patient with a "double disconnection syndrome": a case of subangular alexia in the presence of mixed transcortical aphasia.

    Science.gov (United States)

    Pirozzolo, F J; Kerr, K L; Obrzut, J E; Morley, G K; Haxby, J V; Lundgren, S

    1981-02-01

    In contrast to the classic form of alexia without agraphia, subangular alexia results from a single lesion located deep in the white matter of the left parietal lobe. In the present report, a patient with subangular alexia and features of mixed transcortical aphasia is described. Neurolinguistic findings include: alexia without agraphia, paucity of spontaneous speech, moderate auditory comprehension difficulty, excellent repetition, echopraxia, colour agnosia, and naming disorder. Neurolinguistic tests revealed intact phonological organisation and grammatical filter." Our studies revealed a "double disconnection syndrome," the co-existence of two relatively rare neurobehavioural disorders. Furthermore, the studies reported here clearly show dissociations of language functions in both the visual and auditory modality, which demonstrates that the stages of language processing are separable.

  13. ’n Psigo-opvoedkundige ondersoek na enkele vooronderstellings en konsepte onderliggend aan die Neurolinguistiese Programmeringsmodel

    Directory of Open Access Journals (Sweden)

    C.M. Vorster

    2005-07-01

    Full Text Available A psycho-educational investigation into a few suppositions and concepts underlying the Neuro-linguistic Programming model In the early 1970s a model was developed to identify the therapeutic methods that were used by outstanding psychologists. Eventually the so-called Neuro-linguistic Programming (NLP model was introduced and this model is still used today in many fields such as in psychotherapy with children, in teaching, in the business world and so forth. The purpose of this article is to shed more light on the main presuppositions and concepts underlying the NLP model. This investigation will mainly be undertaken from a psycho-educational perspective. It will, however, also be attempted to concentrate on application possibilities (if any of NLP concepts, taking a Christian point of departure. The most important NPL concepts will be discussed in relation to children on their way to adulthood, whether they are in therapy or in a classroom situation. In conclusion, while referring to the relevance of NLP in psycho-education, certain transcendental-critical perspectives will be provided concerning the most important concepts and presuppositions of NLP.

  14. Natural Language Processing and Machine Learning (NLP/ML): Applying Advances in Biomedicine to the Earth Sciences

    Science.gov (United States)

    Duerr, R.; Myers, S.; Palmer, M.; Jenkins, C. J.; Thessen, A.; Martin, J.

    2015-12-01

    Semantics underlie many of the tools and services available from and on the web. From improving search results to enabling data mashups and other forms of interoperability, semantic technologies have proven themselves. But creating semantic resources, especially re-usable semantic resources, is extremely time consuming and labor intensive. Why? Because it is not just a matter of technology but also of obtaining rough consensus if not full agreement amongst community members on the meaning and order of things. One way to develop these resources in a more automated way would be to use NLP/ML techniques to extract the required resources from large corpora of subject-specific text such as peer-reviewed papers where presumably a rough consensus has been achieved at least about the basics of the particular discipline involved. While not generally applied to Earth Sciences, considerable resources have been spent in other fields such as medicine on these types of techniques with some success. The NSF-funded ClearEarth project is applying the techniques developed for biomedicine to the cryosphere, geology, and biology in order to spur faster development of the semantic resources needed in these fields. The first area being addressed by the project is the cryosphere, specifically sea ice nomenclature where an existing set of sea ice ontologies are being used as the "Gold Standard" against which to test and validate the NLP/ML techniques. The processes being used, lessons learned and early results will be described.

  15. Knowledge representation and management: benefits and challenges of the semantic web for the fields of KRM and NLP.

    Science.gov (United States)

    Rassinoux, A-M

    2011-01-01

    To summarize excellent current research in the field of knowledge representation and management (KRM). A synopsis of the articles selected for the IMIA Yearbook 2011 is provided and an attempt to highlight the current trends in the field is sketched. This last decade, with the extension of the text-based web towards a semantic-structured web, NLP techniques have experienced a renewed interest in knowledge extraction. This trend is corroborated through the five papers selected for the KRM section of the Yearbook 2011. They all depict outstanding studies that exploit NLP technologies whenever possible in order to accurately extract meaningful information from various biomedical textual sources. Bringing semantic structure to the meaningful content of textual web pages affords the user with cooperative sharing and intelligent finding of electronic data. As exemplified by the best paper selection, more and more advanced biomedical applications aim at exploiting the meaningful richness of free-text documents in order to generate semantic metadata and recently to learn and populate domain ontologies. These later are becoming a key piece as they allow portraying the semantics of the Semantic Web content. Maintaining their consistency with documents and semantic annotations that refer to them is a crucial challenge of the Semantic Web for the coming years.

  16. Klik-suri sa Online Community ng mga Lesbiyana sa Facebook Gamit ang Critical Discourse Analysis (CDA at Natural Language Processing (NLP (Click-analysis of a Lesbian Online Community in Facebook Using the CDA and NLP

    Directory of Open Access Journals (Sweden)

    Alona Jumaquio-Ardales

    2017-12-01

    Full Text Available This study aims to describe the discourse on the online community of lesbians in the Philippines. The organization of Lesbian Community or LESCOM was chosen as subject of the study based on high number of ‘likes’ they received in Facebook. The texts were automatically gathered, filtered, shortlisted, and harvested from their Facebook page using the Natural Language Processing (NLP. The theoretical framework of Critical Discourse Analysis (CDA was used in analysing the data in order to describe online discourses that reflect the identity and community of lesbians based in the Philippines. The result of analysis were the following: [1] the emotions projected by exclamatory mark displayed their identity; [2] some plural words served as their voice for being group-oriented; [3] frequent usage of personal names manifested their inclusive community; and [4] social consciousness was part of their organizational agenda.

  17. Drosophila TAP/p32 is a core histone chaperone that cooperates with NAP-1, NLP, and nucleophosmin in sperm chromatin remodeling during fertilization.

    Science.gov (United States)

    Emelyanov, Alexander V; Rabbani, Joshua; Mehta, Monika; Vershilova, Elena; Keogh, Michael C; Fyodorov, Dmitry V

    2014-09-15

    Nuclear DNA in the male gamete of sexually reproducing animals is organized as sperm chromatin compacted primarily by sperm-specific protamines. Fertilization leads to sperm chromatin remodeling, during which protamines are expelled and replaced by histones. Despite our increased understanding of the factors that mediate nucleosome assembly in the nascent male pronucleus, the machinery for protamine removal remains largely unknown. Here we identify four Drosophila protamine chaperones that mediate the dissociation of protamine-DNA complexes: NAP-1, NLP, and nucleophosmin are previously characterized histone chaperones, and TAP/p32 has no known function in chromatin metabolism. We show that TAP/p32 is required for the removal of Drosophila protamine B in vitro, whereas NAP-1, NLP, and Nph share roles in the removal of protamine A. Embryos from P32-null females show defective formation of the male pronucleus in vivo. TAP/p32, similar to NAP-1, NLP, and Nph, facilitates nucleosome assembly in vitro and is therefore a histone chaperone. Furthermore, mutants of P32, Nlp, and Nph exhibit synthetic-lethal genetic interactions. In summary, we identified factors mediating protamine removal from DNA and reconstituted in a defined system the process of sperm chromatin remodeling that exchanges protamines for histones to form the nucleosome-based chromatin characteristic of somatic cells. © 2014 Emelyanov et al.; Published by Cold Spring Harbor Laboratory Press.

  18. The Surface Sensor NlpE of Enterohemorrhagic Escherichia coli Contributes to Regulation of the Type III Secretion System and Flagella by the Cpx Response to Adhesion.

    Science.gov (United States)

    Shimizu, Takeshi; Ichimura, Kimitoshi; Noda, Masatoshi

    2015-12-07

    Although the adhesion of enterohemorrhagic Escherichia coli (EHEC) is central to the EHEC-host interaction during infection, it remains unclear how such adhesion regulates virulence factors. Adhesion to abiotic surfaces by E. coli has been reported to be an outer membrane lipoprotein NlpE-dependent activation cue of the Cpx pathway. Therefore, we investigated the role of NlpE in EHEC on the adhesion-mediated expression of virulence genes. NlpE in EHEC contributed to upregulation of the locus of enterocyte effacement (LEE) genes encoded type III secretion system and to downregulated expression of the flagellin gene by activation of the Cpx pathway during adherence to hydrophobic glass beads and undifferentiated Caco-2 cells. Moreover, LysR homologue A (LrhA) in EHEC was involved in regulating the expression of the LEE genes and flagellin gene in response to adhesion. Gel mobility shift analysis revealed that response regulator CpxR bound to the lrhA promoter region and thereby regulated expressions of the LEE genes and flagellin gene via the transcriptional regulator LrhA in EHEC. Therefore, these results suggest that the sensing of adhesion signals via NlpE is important for regulation of the expression of the type III secretion system and flagella in EHEC during infection. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

  19. Comparison of linear, mixed integer and non-linear programming methods in energy system dispatch modelling

    DEFF Research Database (Denmark)

    Ommen, Torben Schmidt; Markussen, Wiebke Brix; Elmegaard, Brian

    2014-01-01

    differences and differences between the solution found by each optimisation method. One of the investigated approaches utilises LP (linear programming) for optimisation, one uses LP with binary operation constraints, while the third approach uses NLP (non-linear programming). The LP model is used...

  20. Speech and language disorders secondary to diffuse subcortical vascular lesions: Neurolinguistic and acoustic analysis. A case report.

    Science.gov (United States)

    Tomić, Gordana; Stojanović, Milena; Pavlović, Aleksandra; Stanković, Predrag; Zidverc-Trajković, Jasna; Pavlović, Dragan; Marković-Jovanović, Zagorka; Covicković-Sternić, Nadezda

    2009-08-15

    Subcortical white matter (WM) plays an important role in speech production and language processing. Most frequently, cerebral WM lesions are secondary to small vessel disease in patients with vascular risk factors. We report the case of a 53-year-old man with history of hypertension and ischemic subcortical lesions, who presented with speech difficulties and mild cognitive impairment. Language and cognitive assessment included Boston Diagnostic Aphasia Examination, Boston Naming Test, Rey Auditory-Verbal Learning Test, Rey-Osterrieth Complex Figure Test, Trail Making Test A and B, Wisconsin Card Sorting Test, Scale for Evaluation of Perceptive Characteristics of Voice and Speech, and Multidimensional Evaluation of Speech and Voice. Brain MRI showed ischemic WM lesions and lacunar infarcts in the brainstem and right cerebellum. Cognitive testing revealed mild cognitive impairment, predominantly affecting attention and executive functions. Speech and language analysis demonstrated dysarthria, dysphonia with hypophonia, and imprecise articulation, as well as short rushes of speech, palilalia and mild subcortical dysphasia. Neurolinguistic and acoustic analysis in patients with ischemic WM lesions can provide additional information in the understanding of language and speech disturbances, and can assist in patient management.

  1. Effect of electroacupuncture in patients with post-stroke motor aphasia : Neurolinguistic and neuroimaging characteristics.

    Science.gov (United States)

    Chang, Jingling; Zhang, Hua; Tan, Zhongjian; Xiao, Juan; Li, Shuren; Gao, Ying

    2017-02-01

    In this study we investigated the neurolinguistic and neuroimaging characteristics of post-stroke motor aphasia patients. The effects of acupuncture on cortex activation by using magnetic resonance imaging (MRI) in patients with motor aphasia were also studied. In this study 43 patients with motor aphasia after stroke were assessed according to Clinical Rehabilitation Research Center aphasia examination (CRRCAE) for linguistic evaluation and MRI and computed tomography (CT) were used for the analyses of brain lesions. The MRI imaging data were also examined using statistical parametric mapping (SPM8) software. Cortex activation images during acupuncture were analyzed using generalized linear model analysis. The results of MRI and CT showed diverse brain lesion regions of post-stroke motor aphasia including the cortex, subcortex and cortex together with the subcortex. The language-related brain areas are activated by acupuncture including frontal, temporal, parietal and occipital lobes as well as insula, precuneus and other wide range of brain function areas as shown by MRI. Our study showed that the brain lesion regions in post-stroke motor aphasia were not completely consistent with the classical motor speech center. By using MRI our study results suggest that the formation of cognitive language may be involved with the cortical-subcortical functional networks. Acupuncture may be useful for treatment of motor aphasia after stroke.

  2. Is a lone right hemisphere enough? Neurolinguistic architecture in a case with a very early left hemispherectomy.

    Science.gov (United States)

    Danelli, Laura; Cossu, Giuseppe; Berlingeri, Manuela; Bottini, Gabriella; Sberna, Maurizio; Paulesu, Eraldo

    2013-01-01

    We studied the linguistic profile and neurolinguistic organization of a 14-year-old adolescent (EB) who underwent a left hemispherectomy at the age of 2.5 years. After initial aphasia, his language skills recovered within 2 years, with the exception of some word finding problems. Over the years, the neuropsychological assessments showed that EB's language was near-to-normal, with the exception of lexical competence, which lagged slightly behind for both auditory and written language. Moreover, EB's accuracy and speed in both reading and writing words and non-words were within the normal range, whereas difficulties emerged in reading loan words and in tasks with homophones. EB's functional magnetic resonance imaging (fMRI) patterns for several linguistic and metalinguistic tasks were similar to those observed in the dominant hemisphere of controls, suggesting that his language network conforms to a left-like linguistic neural blueprint. However, a stronger frontal recruitment suggests that linguistic tasks are more demanding for him. Finally, no specific reading activation was found in EB's occipitotemporal region, a finding consistent with the surface dyslexia-like behavioral pattern of the patient. While a lone right hemisphere may not be sufficient to guarantee full blown linguistic competences after early hemispherectomy, EB's behavioral and fMRI patterns suggest that his lone right hemisphere followed a left-like blueprint of the linguistic network.

  3. Comparison of linear and nonlinear programming approaches for "worst case dose" and "minmax" robust optimization of intensity-modulated proton therapy dose distributions.

    Science.gov (United States)

    Zaghian, Maryam; Cao, Wenhua; Liu, Wei; Kardar, Laleh; Randeniya, Sharmalee; Mohan, Radhe; Lim, Gino

    2017-03-01

    Robust optimization of intensity-modulated proton therapy (IMPT) takes uncertainties into account during spot weight optimization and leads to dose distributions that are resilient to uncertainties. Previous studies demonstrated benefits of linear programming (LP) for IMPT in terms of delivery efficiency by considerably reducing the number of spots required for the same quality of plans. However, a reduction in the number of spots may lead to loss of robustness. The purpose of this study was to evaluate and compare the performance in terms of plan quality and robustness of two robust optimization approaches using LP and nonlinear programming (NLP) models. The so-called "worst case dose" and "minmax" robust optimization approaches and conventional planning target volume (PTV)-based optimization approach were applied to designing IMPT plans for five patients: two with prostate cancer, one with skull-based cancer, and two with head and neck cancer. For each approach, both LP and NLP models were used. Thus, for each case, six sets of IMPT plans were generated and assessed: LP-PTV-based, NLP-PTV-based, LP-worst case dose, NLP-worst case dose, LP-minmax, and NLP-minmax. The four robust optimization methods behaved differently from patient to patient, and no method emerged as superior to the others in terms of nominal plan quality and robustness against uncertainties. The plans generated using LP-based robust optimization were more robust regarding patient setup and range uncertainties than were those generated using NLP-based robust optimization for the prostate cancer patients. However, the robustness of plans generated using NLP-based methods was superior for the skull-based and head and neck cancer patients. Overall, LP-based methods were suitable for the less challenging cancer cases in which all uncertainty scenarios were able to satisfy tight dose constraints, while NLP performed better in more difficult cases in which most uncertainty scenarios were hard to meet

  4. Mass Spectrometry of Single GABAergic Somatic Motorneurons Identifies a Novel Inhibitory Peptide, As-NLP-22, in the Nematode Ascaris suum

    Science.gov (United States)

    Konop, Christopher J.; Knickelbine, Jennifer J.; Sygulla, Molly S.; Wruck, Colin D.; Vestling, Martha M.; Stretton, Antony O. W.

    2015-12-01

    Neuromodulators have become an increasingly important component of functional circuits, dramatically changing the properties of both neurons and synapses to affect behavior. To explore the role of neuropeptides in Ascaris suum behavior, we devised an improved method for cleanly dissecting single motorneuronal cell bodies from the many other cell processes and hypodermal tissue in the ventral nerve cord. We determined their peptide content using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS). The reduced complexity of the peptide mixture greatly aided the detection of peptides; peptide levels were sufficient to permit sequencing by tandem MS from single cells. Inhibitory motorneurons, known to be GABAergic, contain a novel neuropeptide, As-NLP-22 (SLASGRWGLRPamide). From this sequence and information from the A. suum expressed sequence tag (EST) database, we cloned the transcript ( As-nlp-22) and synthesized a riboprobe for in situ hybridization, which labeled the inhibitory motorneurons; this validates the integrity of the dissection method, showing that the peptides detected originate from the cells themselves and not from adhering processes from other cells (e.g., synaptic terminals). Synthetic As-NLP-22 has potent inhibitory activity on acetylcholine-induced muscle contraction as well as on basal muscle tone. Both of these effects are dose-dependent: the inhibitory effect on ACh contraction has an IC50 of 8.3 × 10-9 M. When injected into whole worms, As-NLP-22 produces a dose-dependent inhibition of locomotory movements and, at higher levels, complete paralysis. These experiments demonstrate the utility of MALDI TOF/TOF MS in identifying novel neuromodulators at the single-cell level.

  5. Performance of a Natural Language Processing (NLP) Tool to Extract Pulmonary Function Test (PFT) Reports from Structured and Semistructured Veteran Affairs (VA) Data.

    Science.gov (United States)

    Sauer, Brian C; Jones, Barbara E; Globe, Gary; Leng, Jianwei; Lu, Chao-Chin; He, Tao; Teng, Chia-Chen; Sullivan, Patrick; Zeng, Qing

    2016-01-01

    Pulmonary function tests (PFTs) are objective estimates of lung function, but are not reliably stored within the Veteran Health Affairs data systems as structured data. The aim of this study was to validate the natural language processing (NLP) tool we developed-which extracts spirometric values and responses to bronchodilator administration-against expert review, and to estimate the number of additional spirometric tests identified beyond the structured data. All patients at seven Veteran Affairs Medical Centers with a diagnostic code for asthma Jan 1, 2006-Dec 31, 2012 were included. Evidence of spirometry with a bronchodilator challenge (BDC) was extracted from structured data as well as clinical documents. NLP's performance was compared against a human reference standard using a random sample of 1,001 documents. In the validation set NLP demonstrated a precision of 98.9 percent (95 percent confidence intervals (CI): 93.9 percent, 99.7 percent), recall of 97.8 percent (95 percent CI: 92.2 percent, 99.7 percent), and an F-measure of 98.3 percent for the forced vital capacity pre- and post pairs and precision of 100 percent (95 percent CI: 96.6 percent, 100 percent), recall of 100 percent (95 percent CI: 96.6 percent, 100 percent), and an F-measure of 100 percent for the forced expiratory volume in one second pre- and post pairs for bronchodilator administration. Application of the NLP increased the proportion identified with complete bronchodilator challenge by 25 percent. This technology can improve identification of PFTs for epidemiologic research. Caution must be taken in assuming that a single domain of clinical data can completely capture the scope of a disease, treatment, or clinical test.

  6. Volar locking plate (VLP) versus non-locking plate (NLP) in the treatment of die-punch fractures of the distal radius, an observational study.

    Science.gov (United States)

    Zhang, Xiong; Hu, Chunhe; Yu, Kunlun; Bai, Jiangbo; Tian, Dehu; Xu, Yi; Zhang, Bing

    2016-10-01

    This study aims to evaluate whether volar locking plate was superior over non-locking plate in the treatment of die-punch fractures of the distal radius. A total of 57 patients with closed die-punch fractures of the distal radius were included and analyzed. Of them, 32 were treated by non-locking plate (NLP) and the remaining 25 were treated by volar locking plate (VLP). Preoperative radiographs, computer tomographs and three-dimensional reconstruction, radiographs taken at immediate postoperation and at last follow-up were extracted and evaluated. Patients' electronic medical records were inquired and related demographic and medical data were documented. The documented contents were volar tilt, radial inclination, ulnar variance, grip strength, Disabilities of the Arm, Shoulder, and Hand (DASH) and visual analog scale (VAS) scores and complications. VLP group demonstrated a significantly reduced radial subsidence of 1.5 mm (0.7 versus 2.2 mm), during the interval of bony union (P NLP group. Larger proportion of patients (88% versus 62.5%) in VLP group gained acceptable joint congruity (step-off NLP groups, although the difference did not approach to significance (P = 0.339, 0.372). VLP leaded to significantly better results of reduction maintainance and the final joint congruity than NLP, while reducing overall and major complications. However, the results should be treated in the context of limitations and the clinical significance of the difference required further studies to investigate. Copyright © 2016 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.

  7. Structural Analysis of Papain-Like NlpC/P60 Superfamily Enzymes with a Circularly Permuted Topology Reveals Potential Lipid Binding Sites

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Qingping; Rawlings, Neil D.; Chiu, Hsiu-Ju; Jaroszewski, Lukasz; Klock, Heath E.; Knuth, Mark W.; Miller, Mitchell D.; Elsliger, Marc-Andre; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A. (SG); (Wellcome)

    2012-07-11

    NlpC/P60 superfamily papain-like enzymes play important roles in all kingdoms of life. Two members of this superfamily, LRAT-like and YaeF/YiiX-like families, were predicted to contain a catalytic domain that is circularly permuted such that the catalytic cysteine is located near the C-terminus, instead of at the N-terminus. These permuted enzymes are widespread in virus, pathogenic bacteria, and eukaryotes. We determined the crystal structure of a member of the YaeF/YiiX-like family from Bacillus cereus in complex with lysine. The structure, which adopts a ligand-induced, 'closed' conformation, confirms the circular permutation of catalytic residues. A comparative analysis of other related protein structures within the NlpC/P60 superfamily is presented. Permutated NlpC/P60 enzymes contain a similar conserved core and arrangement of catalytic residues, including a Cys/His-containing triad and an additional conserved tyrosine. More surprisingly, permuted enzymes have a hydrophobic S1 binding pocket that is distinct from previously characterized enzymes in the family, indicative of novel substrate specificity. Further analysis of a structural homolog, YiiX (PDB 2if6) identified a fatty acid in the conserved hydrophobic pocket, thus providing additional insights into possible function of these novel enzymes.

  8. Toward a Learning Health-care System – Knowledge Delivery at the Point of Care Empowered by Big Data and NLP

    Science.gov (United States)

    Kaggal, Vinod C.; Elayavilli, Ravikumar Komandur; Mehrabi, Saeed; Pankratz, Joshua J.; Sohn, Sunghwan; Wang, Yanshan; Li, Dingcheng; Rastegar, Majid Mojarad; Murphy, Sean P.; Ross, Jason L.; Chaudhry, Rajeev; Buntrock, James D.; Liu, Hongfang

    2016-01-01

    The concept of optimizing health care by understanding and generating knowledge from previous evidence, ie, the Learning Health-care System (LHS), has gained momentum and now has national prominence. Meanwhile, the rapid adoption of electronic health records (EHRs) enables the data collection required to form the basis for facilitating LHS. A prerequisite for using EHR data within the LHS is an infrastructure that enables access to EHR data longitudinally for health-care analytics and real time for knowledge delivery. Additionally, significant clinical information is embedded in the free text, making natural language processing (NLP) an essential component in implementing an LHS. Herein, we share our institutional implementation of a big data-empowered clinical NLP infrastructure, which not only enables health-care analytics but also has real-time NLP processing capability. The infrastructure has been utilized for multiple institutional projects including the MayoExpertAdvisor, an individualized care recommendation solution for clinical care. We compared the advantages of big data over two other environments. Big data infrastructure significantly outperformed other infrastructure in terms of computing speed, demonstrating its value in making the LHS a possibility in the near future. PMID:27385912

  9. Using NLP meta, Milton, metaphor models, for improving the activity of the organization

    Directory of Open Access Journals (Sweden)

    Cornel Marian IOSIF

    2010-12-01

    Full Text Available The objective of this paper is the improving of the three methods from the neuro- linguistic programming – metaphor, Milton model and the meta-model, so by using this in daily activities by an organization to improve the activities witch, are performed and to have a more efficient allocation of the available resources.

  10. Neuro-Linguistic Programming and Altered States: Encouraging Preparation for Learning in the Classroom for Students with Special Educational Needs

    Science.gov (United States)

    Kudliskis, Voldis

    2013-01-01

    In seeking to identify the processes associated with the immediate engagement of learning for students with mild special educational needs, this study examined the responses of an extraction group (n = 7) of 11- to 13-year-old students who participated in a number of lessons in which the opening episode involved the use of visualisation techniques…

  11. Plant Omics Data Center: an integrated web repository for interspecies gene expression networks with NLP-based curation.

    Science.gov (United States)

    Ohyanagi, Hajime; Takano, Tomoyuki; Terashima, Shin; Kobayashi, Masaaki; Kanno, Maasa; Morimoto, Kyoko; Kanegae, Hiromi; Sasaki, Yohei; Saito, Misa; Asano, Satomi; Ozaki, Soichi; Kudo, Toru; Yokoyama, Koji; Aya, Koichiro; Suwabe, Keita; Suzuki, Go; Aoki, Koh; Kubo, Yasutaka; Watanabe, Masao; Matsuoka, Makoto; Yano, Kentaro

    2015-01-01

    Comprehensive integration of large-scale omics resources such as genomes, transcriptomes and metabolomes will provide deeper insights into broader aspects of molecular biology. For better understanding of plant biology, we aim to construct a next-generation sequencing (NGS)-derived gene expression network (GEN) repository for a broad range of plant species. So far we have incorporated information about 745 high-quality mRNA sequencing (mRNA-Seq) samples from eight plant species (Arabidopsis thaliana, Oryza sativa, Solanum lycopersicum, Sorghum bicolor, Vitis vinifera, Solanum tuberosum, Medicago truncatula and Glycine max) from the public short read archive, digitally profiled the entire set of gene expression profiles, and drawn GENs by using correspondence analysis (CA) to take advantage of gene expression similarities. In order to understand the evolutionary significance of the GENs from multiple species, they were linked according to the orthology of each node (gene) among species. In addition to other gene expression information, functional annotation of the genes will facilitate biological comprehension. Currently we are improving the given gene annotations with natural language processing (NLP) techniques and manual curation. Here we introduce the current status of our analyses and the web database, PODC (Plant Omics Data Center; http://bioinf.mind.meiji.ac.jp/podc/), now open to the public, providing GENs, functional annotations and additional comprehensive omics resources. © The Author 2014. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists.

  12. Limited parsing of notational text visit notes: ad-hoc vs. NLP approaches.

    Science.gov (United States)

    Barrows Jr, R C; Busuioc, M; Friedman, C

    2000-01-01

    This paper describes the extraction of structured data relevant to glaucoma diagnosis and progression from visit notes typed as "notational text" by ophthalmologists during patient encounters. We compared two text processing systems: a limited pattern matching system called GDP (Glaucoma Dedicated Parser) and MedLEE, a proven natural language processing system which is in routine use encoding findings from chest radiograph and mammogram reports at the New York-Presbyterian hospital's Columbia-Presbyterian Center. We also evaluated the use of GDP as a preprocessor program to transform notational text into constructions recognizable by MedLEE. These systems have been evaluated according to their recall and precision in the particular task of processing a corpus of "notational text" documents to extract information related to glaucoma disease.

  13. Using NLP Reframing, Metaprograme Methods for Improving the Activity of the Organization

    Directory of Open Access Journals (Sweden)

    Iosif Cornel Marian

    2011-12-01

    Full Text Available The new method by increasing the adaptation speed to a context, through a slight transformation of the contextual meaning of words and by the optimization of the phases in which the actual process of reframing provides a closer connection between the person and context, a better adaptation to the language contextual requirements, but also to reduce the steps in which the process of reframing is done, which is a higher efficiency of it and a lower consumption of resources. By improving the programs and filters that are serving to metaprograms, the environmental information will be obtained at a high quality, the redundancy will decrease, and the consumption of resources needed to perform the filtering of information will also be reduced.Keywords: optimization, efficient, reduce, improve, communication

  14. Neurolinguistic measures of typological effects in multilingual transfer: Introducing an ERP methodology

    Directory of Open Access Journals (Sweden)

    Jason eRothman

    2015-08-01

    Full Text Available This article has two main objectives. First, we offer an introduction to the subfield of generative third language (L3 acquisition. Concerned primarily with modeling initial stages transfer of morphosyntax, one goal of this program is to show how initial stages L3 data make significant contributions towards a better understanding of how the mind represents language and how (cognitive economy constrains acquisition processes more generally. Our second objective is to argue for and demonstrate how this subfield will benefit from a neuro/psycholinguistic methodological approach, such as event related potential (ERP experiments, to complement the claims currently made on the basis of exclusively behavioral experiments.

  15. Neurolinguistic measures of typological effects in multilingual transfer: introducing an ERP methodology.

    Science.gov (United States)

    Rothman, Jason; Alemán Bañón, José; González Alonso, Jorge

    2015-01-01

    This article has two main objectives. First, we offer an introduction to the subfield of generative third language (L3) acquisition. Concerned primarily with modeling initial stages transfer of morphosyntax, one goal of this program is to show how initial stages L3 data make significant contributions toward a better understanding of how the mind represents language and how (cognitive) economy constrains acquisition processes more generally. Our second objective is to argue for and demonstrate how this subfield will benefit from a neuro/psycholinguistic methodological approach, such as event-related potential experiments, to complement the claims currently made on the basis of exclusively behavioral experiments.

  16. Towards a computational(ist) neurobiology of language: Correlational, integrated, and explanatory neurolinguistics*

    Science.gov (United States)

    Poeppel, David

    2014-01-01

    We outline what an integrated approach to language research that connects experimental, theoretical, and neurobiological domains of inquiry would look like, and ask to what extent unification is possible across domains. At the center of the program is the idea that computational/representational (CR) theories of language must be used to investigate its neurobiological (NB) foundations. We consider different ways in which CR and NB might be connected. These are (1) A Correlational way, in which NB computation is correlated with the CR theory; (2) An Integrated way, in which NB data provide crucial evidence for choosing among CR theories; and (3) an Explanatory way, in which properties of NB explain why a CR theory is the way it is. We examine various questions concerning the prospects for Explanatory connections in particular, including to what extent it makes sense to say that NB could be specialized for particular computations. PMID:25914888

  17. Aproximaciones lingüísticas a la afasiología en torno a la repetición Neurolinguistic approaches about aphasia

    Directory of Open Access Journals (Sweden)

    Lluis Barraquer Bordas

    2007-09-01

    Full Text Available Las afasias son una patología del lenguaje y éste es un sistema de mediación cultural lógica, situado netamente por encima de lo meramente natural. Arranca de la función simbólica, que establece la distinción y el nexo entre significante y significado. Se establece, a grandes rasgos, una clasificación neurolingüística de las afasias, rechazando las expresiones inadecuadas de sensitiva o sensorial y motora. Se insiste particularmente aquí sobre la cuestión de la "repetición" en la semiología afásica, tanto en lo que se refiere a su pérdida como a su "exaltación". Ello conduce a una revisión de la mal llamada afasia "de conducción" y del "transcorticalismo".Aphasias are language pathologies, therefore the acquaintance of its structure is required for proper understanding. Language is a cultural interaction system, logical, set much above common natural. It separates the symbolic function, which establishes the distinction between significant and signification. We establish a neurolinguistic classification of aphasias, refuting improper expressions. We broach the wrongly called "conduction aphasia". We detach the unit of speech act and we distinguish the existence of a joint project that sheds light on all sentences brought forth. The complex texture of the "transcorticalism" qualify is analyzed. Aphasia field and some forms of its unfolding are questions aborded under the light of basic neurolinguistic concepts. We detach the unit of speech act and we distinguish the existence of a common project that sheds light on all sentences brought forth.

  18. Comparison of batch cultivation strategies for cost-effective biomass production of Micractinium inermum NLP-F014 using a blended wastewater medium.

    Science.gov (United States)

    Park, Seonghwan; Kim, Jeongmi; Park, Younghyun; Son, Suyoung; Cho, Sunja; Kim, Changwon; Lee, Taeho

    2017-06-01

    Two competitive strategies, fed-batch and sequencing-batch cultivation, were compared in cost-effective biomass production of a high lipid microalgae, Micractinium inermum NLP-F014 using a blended wastewater medium. For fed-batch cultivations, additional nutrient was supplemented at day 2 (FB1) or consecutively added at day 2 and 4 (FB2). Through inoculum size test, 1.0g-DCWL -1 was selected for the sequencing-batch cultivation (SB) where about 65% of culture was replaced with fresh medium every 2days. Both fed-batch cultivations showed the maximum biomass productivity of 0.95g-DCWL -1 d -1 , while average biomass productivity in SB was slightly higher as 0.96±0.08g-DCWL -1 d -1 . Furthermore, remained concentrations of organics (426mg-CODL -1 ), total nitrogen (15.4mg-NL -1 ) and phosphorus (0.6mg-PL -1 ) in SB were much lower than those of fed-batch conditions. The results suggested that SB could be a promising strategy to cultivate M. inermum NLP-F014 with the blended wastewater medium. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Neurolinguistic Aspects of Bilingualism.

    Science.gov (United States)

    Goral, Mira; Levy, Erika S.; Obler, Loraine K.

    2002-01-01

    Discusses aphasia, the language deficit resulting from damage to the language centers of the brain, in order to evaluate how research on bilingual and polyglot aphasic individuals has contributed to our knowledge of the representation of language and languages in neurologically intact humans' brains. Examines the literature on treating lateral…

  20. How Did an Antismoking Campaign with a Neuro Linguistic Program Work out? A Case Study of Secondary School Students' Experiences in One Finnish School

    Science.gov (United States)

    Sahi, Salme; Maatta, Kaarina

    2013-01-01

    This article describes the use of a Neuro Linguistic Program (NLP) in an antismoking campaign and studies how successful this campaign was according to secondary school students. This campaign was carried out in a small town in northern Finland as an intensive three-day-long campaign. The data consisted of the essays and interviews of those…

  1. Natural Language Processing Using Spreading Activation and Lateral Inhibition.

    Science.gov (United States)

    1982-08-01

    system; and by Gigley, [1982J who has built a neurolinguistically -inspirod NLP system capable of simulating aphasia behavior. I. E~~using Soredas...Fahlan, S.E., MM: A irem J RegresenL Ing A U-ing. ksj-][zrld Kwledg.e. MIT Press, 1979. Gisley, H., A Computational Neurolinguistic Approach to

  2. Solutions manual to accompany Nonlinear programming

    CERN Document Server

    Bazaraa, Mokhtar S; Shetty, C M

    2014-01-01

    As the Solutions Manual, this book is meant to accompany the main title, Nonlinear Programming: Theory and Algorithms, Third Edition. This book presents recent developments of key topics in nonlinear programming (NLP) using a logical and self-contained format. The volume is divided into three sections: convex analysis, optimality conditions, and dual computational techniques. Precise statements of algortihms are given along with convergence analysis. Each chapter contains detailed numerical examples, graphical illustrations, and numerous exercises to aid readers in understanding the concepts a

  3. The method of global learning in teaching foreign languages

    Directory of Open Access Journals (Sweden)

    Tatjana Dragovič

    2001-12-01

    Full Text Available The authors describe the method of global learning of foreign languages, which is based on the principles of neurolinguistic programming (NLP. According to this theory, the educator should use the method of the so-called periphery learning, where students learn relaxation techniques and at the same time they »incidentally « or subconsciously learn a foreign language. The method of global learning imitates successful strategies of learning in early childhood and therefore creates a relaxed attitude towards learning. Global learning is also compared with standard methods.

  4. Developing safer systems in a NPP environment using the operator`s comfort parameters and virtual reality

    Energy Technology Data Exchange (ETDEWEB)

    Brown-VanHoozer, S.A.

    1995-07-01

    The contents of this paper is based on two studies involving the design of visual displays from the operator`s point of view, and the utilization of virtual reality for operations, training and maintenance repairs. The studies involve a methodology known as Neuro-Linguistic Programming (NLP), and its use in strengthening design choices from the user`s perspective model of the environment. The contents of this paper focuses on the results which may be implemented in nuclear power plants for the purpose of providing systems which are less inherently error prone.

  5. Evidence-based Neuro Linguistic Psychotherapy: a meta-analysis.

    Science.gov (United States)

    Zaharia, Cătălin; Reiner, Melita; Schütz, Peter

    2015-12-01

    Neuro Linguistic Programming (NLP) Framework has enjoyed enormous popularity in the field of applied psychology. NLP has been used in business, education, law, medicine and psychotherapy to identify people's patterns and alter their responses to stimuli, so they are better able to regulate their environment and themselves. NLP looks at achieving goals, creating stable relationships, eliminating barriers such as fears and phobias, building self-confidence, and self-esteem, and achieving peak performance. Neuro Linguistic Psychotherapy (NLPt) encompasses NLP as framework and set of interventions in the treatment of individuals with different psychological and/or social problems. We aimed systematically to analyse the available data regarding the effectiveness of Neuro Linguistic Psychotherapy (NLPt). The present work is a meta-analysis of studies, observational or randomized controlled trials, for evaluating the efficacy of Neuro Linguistic Programming in individuals with different psychological and/or social problems. The databases searched to identify studies in English and German language: CENTRAL in the Cochrane Library; PubMed; ISI Web of Knowledge (include results also from Medline and the Web of Science); PsycINFO (including PsycARTICLES); Psyndex; Deutschsprachige Diplomarbeiten der Psychologie (database of theses in Psychology in German language), Social SciSearch; National library of health and two NLP-specific research databases: one from the NLP Community (http://www.nlp.de/cgi-bin/research/nlprdb.cgi?action=res_entries) and one from the NLP Group (http://www.nlpgrup.com/bilimselarastirmalar/bilimsel-arastirmalar-4.html#Zweig154). From a total number of 425 studies, 350 were removed and considered not relevant based on the title and abstract. Included, in the final analysis, are 12 studies with numbers of participants ranging between 12 and 115 subjects. The vast majority of studies were prospective observational. The actual paper represents the first

  6. Die meting van neurolinguistiese programmering se verteenwoordigende stelsels: 'n Eksploratiewe studie

    Directory of Open Access Journals (Sweden)

    P. C. Bester

    2000-06-01

    Full Text Available The measurement of neurolinguistic programming's representative systems: an Exploratory study. An overview of Psychology literature indicates that various authors have agreed upon the existence of Neurolinguistic Programming's (NLP representative systems. Until recently, no study has been reported in the literature that offers a comprehensive measuring instrument for these constructs. The principal aim of this study was to determine the desirability of measuring NLPs representative systems with a comprehensive normative questionnaire. Three theoretical constructs were hypothesized and a "Questionnaire on Sensory Modalities" consisting of 84 items was developed. This questionnaire was administered to students (N=338 from three different tertiary institutions. A second factor analysis on the 18 subscores of a first factor analysis, yielded two factors that did not reflect the three representative systems. The implications of these findings are discussed.Opsomming 'n Oorsig van die Sielkunde-literatuur wys daarop dat verskeie outeurs saamstem oor die bestaan van Neurolinguistiese Programmering (NLP se verteenwoordigende stelsels. Tot onlangs toe is geen studie oor die bestaan van n omvattende meetinstrument vir NLP se verteenwoordigende stelsels in die literatuur gerapporteer nie. Die hoofdoel van die onderhawige studie was om vas te stel of dit wenslik is om NLP se verteenwoordigende stelsels met 'n omvattende normatiewe vraelys te meet. Drie konstrukte is voorveronderstel en 'n "Vraelys oor Sensoriese Modaliteite", bestaande uit 84 items, is gekonstrueer. Hierdie vraelys is afgeneem op studente (N=338 van drie verskillende tersiere instellings. hTweede faktorontleding op die 18 subtellings van n eerste faktorontleding, het twee faktore opgelewer wat nie die drie verteenwoordigende stelsels suiwer weergee nie. Die implikasies van hierdie bevindinge word bespreek.

  7. Blending water- and nutrient-source wastewaters for cost-effective cultivation of high lipid content microalgal species Micractinium inermum NLP-F014.

    Science.gov (United States)

    Park, Seonghwan; Kim, Jeongmi; Yoon, Youngjin; Park, Younghyun; Lee, Taeho

    2015-12-01

    The possibility of utilizing blended wastewaters from different streams was investigated for cost-efficient microalgal cultivation. The influent of a domestic wastewater treatment plant and the liquid fertilizer from a swine wastewater treatment plant were selected as water- and nutrient-source wastewaters, respectively. The growth of Micractinium inermum NLP-F014 in the blended wastewater medium without any pretreatment was comparable to that in Bold's Basal Medium. The optimum blending ratio of 5-15% (vv(-1)) facilitated biomass production up to 5.7 g-dry cell weight (DCW) L(-1), and the maximum biomass productivity (1.03 g-DCWL(-1)d(-1)) was achieved after three days of cultivation. Nutrient depletion induced lipid accumulation in the cell up to 39.1% (ww(-1)) and the maximum lipid productivity was 0.19 g-FAMEL(-1)d(-1). These results suggest that blending water- and nutrient-source wastewaters at a proper ratio without pretreatment can significantly cut costs in microalgae cultivation for biodiesel production. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. Dense Annotation of Free-Text Critical Care Discharge Summaries from an Indian Hospital and Associated Performance of a Clinical NLP Annotator.

    Science.gov (United States)

    Ramanan, S V; Radhakrishna, Kedar; Waghmare, Abijeet; Raj, Tony; Nathan, Senthil P; Sreerama, Sai Madhukar; Sampath, Sriram

    2016-08-01

    Electronic Health Record (EHR) use in India is generally poor, and structured clinical information is mostly lacking. This work is the first attempt aimed at evaluating unstructured text mining for extracting relevant clinical information from Indian clinical records. We annotated a corpus of 250 discharge summaries from an Intensive Care Unit (ICU) in India, with markups for diseases, procedures, and lab parameters, their attributes, as well as key demographic information and administrative variables such as patient outcomes. In this process, we have constructed guidelines for an annotation scheme useful to clinicians in the Indian context. We evaluated the performance of an NLP engine, Cocoa, on a cohort of these Indian clinical records. We have produced an annotated corpus of roughly 90 thousand words, which to our knowledge is the first tagged clinical corpus from India. Cocoa was evaluated on a test corpus of 50 documents. The overlap F-scores across the major categories, namely disease/symptoms, procedures, laboratory parameters and outcomes, are 0.856, 0.834, 0.961 and 0.872 respectively. These results are competitive with results from recent shared tasks based on US records. The annotated corpus and associated results from the Cocoa engine indicate that unstructured text mining is a viable method for cohort analysis in the Indian clinical context, where structured EHR records are largely absent.

  9. A la Recherche du Temps Perdu: extracting temporal relations from medical text in the 2012 i2b2 NLP challenge.

    Science.gov (United States)

    Cherry, Colin; Zhu, Xiaodan; Martin, Joel; de Bruijn, Berry

    2013-01-01

    An analysis of the timing of events is critical for a deeper understanding of the course of events within a patient record. The 2012 i2b2 NLP challenge focused on the extraction of temporal relationships between concepts within textual hospital discharge summaries. The team from the National Research Council Canada (NRC) submitted three system runs to the second track of the challenge: typifying the time-relationship between pre-annotated entities. The NRC system was designed around four specialist modules containing statistical machine learning classifiers. Each specialist targeted distinct sets of relationships: local relationships, 'sectime'-type relationships, non-local overlap-type relationships, and non-local causal relationships. The best NRC submission achieved a precision of 0.7499, a recall of 0.6431, and an F1 score of 0.6924, resulting in a statistical tie for first place. Post hoc improvements led to a precision of 0.7537, a recall of 0.6455, and an F1 score of 0.6954, giving the highest scores reported on this task to date. Methods for general relation extraction extended well to temporal relations, and gave top-ranked state-of-the-art results. Careful ordering of predictions within result sets proved critical to this success.

  10. NLP techniques associated with the OpenGALEN ontology for semi-automatic textual extraction of medical knowledge: abstracting and mapping equivalent linguistic and logical constructs.

    Science.gov (United States)

    do Amaral, M B; Roberts, A; Rector, A L

    2000-01-01

    This research project presents methodological and theoretical issues related to the inter-relationship between linguistic and conceptual semantics, analysing the results obtained by the application of a NLP parser to a set of radiology reports. Our objective is to define a technique for associating linguistic methods with domain specific ontologies for semi-automatic extraction of intermediate representation (IR) information formats and medical ontological knowledge from clinical texts. We have applied the Edinburgh LTG natural language parser to 2810 clinical narratives describing radiology procedures. In a second step, we have used medical expertise and ontology formalism for identification of semantic structures and abstraction of IR schemas related to the processed texts. These IR schemas are an association of linguistic and conceptual knowledge, based on their semantic contents. This methodology aims to contribute to the elaboration of models relating linguistic and logical constructs based on empirical data analysis. Advance in this field might lead to the development of computational techniques for automatic enrichment of medical ontologies from real clinical environments, using descriptive knowledge implicit in large text corpora sources.

  11. An Evaluative Review of Hemispheric Learning Potential

    Science.gov (United States)

    1985-10-01

    abilities of both the hemispheres. Specific learning gains on standardized tests have been reported. Neurolinguistic programing is a technique...transformed into possibilities; problems into creative opportunities (U.K. Training Centre broadsheet). Neurolinguistic programing can even be employed to...also draw on suggestopedia and neurolinguistic programing, together with yoga. Inner Track Learning suggests that Recent research has shown that

  12. Theoretical and algorithmic advances in multi-parametric programming and control

    KAUST Repository

    Pistikopoulos, Efstratios N.

    2012-04-21

    This paper presents an overview of recent theoretical and algorithmic advances, and applications in the areas of multi-parametric programming and explicit/multi-parametric model predictive control (mp-MPC). In multi-parametric programming, advances include areas such as nonlinear multi-parametric programming (mp-NLP), bi-level programming, dynamic programming and global optimization for multi-parametric mixed-integer linear programming problems (mp-MILPs). In multi-parametric/explicit MPC (mp-MPC), advances include areas such as robust multi-parametric control, multi-parametric nonlinear MPC (mp-NMPC) and model reduction in mp-MPC. A comprehensive framework for multi-parametric programming and control is also presented. Recent applications include a hydrogen storage device, a fuel cell power generation system, an unmanned autonomous vehicle (UAV) and a hybrid pressure swing adsorption (PSA) system. © 2012 Springer-Verlag.

  13. Anadilden Sonra Öğrenilen Dilde Dilbilgisel İşlemleme: Geç İkidilliliğin Beyindilbilimi Açısından Değerlendirilmesi (Processing in The Late-Learned Language: A Neurolinguistic Approach To Late Bilingualism

    Directory of Open Access Journals (Sweden)

    Filiz MERGEN

    2011-10-01

    Full Text Available Language acquisition is a natural process which proceeds remarkably easily for children. The late-learned language, however, especially when it is learned formally in the classroom poses serious problems for many individuals who fail to learn grammatical structures and use and comprehend them in communicative settings. Whereas production and comprehension of some grammatical structures can be mastered easily, others are hard to learn and rarely do they reach native-like levels. This paper looks into the processing difficulties of the late-learned language from a neurolinguistic perspective and evaluates comprehension studies in the literature which investigated grammatical processing.

  14. A tulajdonnevek pszicho- és neurolingvisztikája. Vizsgálati szempontok és modellek a tulajdonnevek feldolgozásáról [The psycho- and neurolinguistics of proper names. Aspects and models of analysis on processing proper names

    Directory of Open Access Journals (Sweden)

    Reszegi, Katalin

    2014-12-01

    Full Text Available This paper provides an overview of the results of psycho- and neurolinguistic examinations into the mental processes involving proper names (i.e. storing, processing, retrieving proper names. We can denote entities of various types with the help of proper names, and although most of these types are universal, there are in fact some cultural differences. In the fields of science concerned, that is, in psycho- and neurolinguistics and in neuropsychology, attention is given almost exclusively to anthroponyms; mental and neurological features of toponyms and other name types are much less examined. Processing names is generally believed to display more difficulties than processing common nouns, and these difficulties present themselves more and more strongly with age. In connection with the special identifying function and semantic features of proper names, many researchers assume that we process the two groups of words in different ways. This paper, reflecting also on these assumptions, summarizes and explains the results of research into a selective anomia affecting monolingual speakers (word-finding disturbances; b localization; c reaction time measurement; and d speech disfluency concerning proper names (especially the “tip of the tongue phenomenon”. The author also presents the models of processing proper names, examining to what degree these models can be reconciled with our knowledge of the acquisition of proper names. Finally, the results and possible explanations of the small amount of research into the representation and processing of proper names by bilingual speakers are discussed.

  15. NLP modeling for the optimization of LiBr-H2O absorption refrigeration systems with exergy loss rate, heat transfer area, and cost as single objective functions

    DEFF Research Database (Denmark)

    Mussati, Sergio F.; Gernaey, Krist; Morosuk, Tatiana

    2016-01-01

    Based on a nonlinear mathematical programming model, the sizes and operating conditions of the process units of single-effect absorption refrigeration systems operating with a LiBr–H2O solution are optimized for a specified cooling capacity by minimizing three single objective functions: the tota...

  16. Extraction of Static and Dynamic Reservoir Operation Rules by Genetic Programming

    Directory of Open Access Journals (Sweden)

    Habib Akbari Alashti

    2014-11-01

    Full Text Available Considering the necessity of desirable operation of limited water resources and assuming the significant role of dams in controlling and consuming the surface waters, highlights the advantageous of suitable operation rules for optimal and sustainable operation of dams. This study investigates the hydroelectric supply of a one-reservoir system of Karoon3 using nonlinear programming (NLP, genetic algorithm (GA, genetic programming (GP and fixed length gen GP (FLGGP in real-time operation of dam considering two approaches of static and dynamic operation rules. In static operation rule, only one rule curve is extracted for all months in a year whereas in dynamic operation rule, monthly rule curves (12 rules are extracted for each month of a year. In addition, nonlinear decision rule (NLDR curves are considered, and the total deficiency function as the target (objective function have been used for evaluating the performance of each method and approach. Results show appropriate efficiency of GP and FLGGP methods in extracting operation rules in both approaches. Superiority of these methods to operation methods yielded by GA and NLP is 5%. Moreover, according to the results, it can be remarked that, FLGGP method is an alternative for GP method, whereas the GP method cannot be used due to its limitations. Comparison of two approaches of static and dynamic operation rules demonstrated the superiority of dynamic operation rule to static operation rule (about 10% and therefore this method has more capabilities in real-time operation of the reservoirs systems.

  17. Fuzzy physical programming for Space Manoeuvre Vehicles trajectory optimization based on hp-adaptive pseudospectral method

    Science.gov (United States)

    Chai, Runqi; Savvaris, Al; Tsourdos, Antonios

    2016-06-01

    In this paper, a fuzzy physical programming (FPP) method has been introduced for solving multi-objective Space Manoeuvre Vehicles (SMV) skip trajectory optimization problem based on hp-adaptive pseudospectral methods. The dynamic model of SMV is elaborated and then, by employing hp-adaptive pseudospectral methods, the problem has been transformed to nonlinear programming (NLP) problem. According to the mission requirements, the solutions were calculated for each single-objective scenario. To get a compromised solution for each target, the fuzzy physical programming (FPP) model is proposed. The preference function is established with considering the fuzzy factor of the system such that a proper compromised trajectory can be acquired. In addition, the NSGA-II is tested to obtain the Pareto-optimal solution set and verify the Pareto optimality of the FPP solution. Simulation results indicate that the proposed method is effective and feasible in terms of dealing with the multi-objective skip trajectory optimization for the SMV.

  18. The ClearEarth Project: Preliminary Findings from Experiments in Applying the CLEARTK NLP Pipeline and Annotation Tools Developed for Biomedicine to the Earth Sciences

    Science.gov (United States)

    Duerr, R.; Thessen, A.; Jenkins, C. J.; Palmer, M.; Myers, S.; Ramdeen, S.

    2016-12-01

    The ability to quickly find, easily use and effortlessly integrate data from a variety of sources is a grand challenge in Earth sciences, one around which entire research programs have been built. A myriad of approaches to tackling components of this challenge have been demonstrated, often with some success. Yet finding, assessing, accessing, using and integrating data remains a major challenge for many researchers. A technology that has shown promise in nearly every aspect of the challenge is semantics. Semantics has been shown to improve data discovery, facilitate assessment of a data set, and through adoption of the W3C's Linked Data Platform to have improved data integration and use at least for data amenable to that paradigm. Yet the creation of semantic resources has been slow. Why? Amongst a plethora of other reasons, it is because semantic expertise is rare in the Earth and Space sciences; the creation of semantic resources for even a single discipline is labor intensive and requires agreement within the discipline; best practices, methods and tools for supporting the creation and maintenance of the resources generated are in flux; and the human and financial capital needed are rarely available in the Earth sciences. However, other fields, such as biomedicine, have made considerable progress in these areas. The NSF-funded ClearEarth project is adapting the methods and tools from these communities for the Earth sciences in the expectation that doing so will enhance progress and the rate at which the needed semantic resources are created. We discuss progress and results to date, lessons learned from this adaptation process, and describe our upcoming efforts to extend this knowledge to the next generation of Earth and data scientists.

  19. Visual imagery and the user model applied to fuel handling at EBR-II

    Energy Technology Data Exchange (ETDEWEB)

    Brown-VanHoozer, S.A.

    1995-06-01

    The material presented in this paper is based on two studies involving visual display designs and the user`s perspective model of a system. The studies involved a methodology known as Neuro-Linguistic Programming (NLP), and its use in expanding design choices which included the ``comfort parameters`` and ``perspective reality`` of the user`s model of the world. In developing visual displays for the EBR-II fuel handling system, the focus would be to incorporate the comfort parameters that overlap from each of the representation systems: visual, auditory and kinesthetic then incorporate the comfort parameters of the most prominent group of the population, and last, blend in the other two representational system comfort parameters. The focus of this informal study was to use the techniques of meta-modeling and synesthesia to develop a virtual environment that closely resembled the operator`s perspective of the fuel handling system of Argonne`s Experimental Breeder Reactor - II. An informal study was conducted using NLP as the behavioral model in a v reality (VR) setting.

  20. La programación neurolingüística como herramienta estratégica para el gerente negociador

    National Research Council Canada - National Science Library

    Torres Amaya, Edith J

    2006-01-01

    ... to effective communication, where the neurolinguistic programming, the body and oral language become very important allowing to define the dynamics where the organizational relations will be developed...

  1. MODERN THAMIZH SANDHI RULES GENERATOR IN NLP

    Directory of Open Access Journals (Sweden)

    K. Nirmala

    2015-10-01

    Full Text Available Thamizh sandhi rules generator deals with addition, deletion, getting changes with existing Information and this adjoining letters/sandhi grammar rules processing with indirect/bi-lingual machine translation. This Modern Thamizh Sandhi Rules Generator is implemented under Unicode based Indic Script. Modern Thamizh sandhi generation is the initial stage of developing the Word Formation rules in Thamizh computational method.

  2. Dictionaries of Mexican Sexual Slang for NLP

    Directory of Open Access Journals (Sweden)

    Roberto Villarejo-Martínez

    2017-04-01

    Full Text Available In this paper the creation of two relevant resources for the double entendre and humour recognition problem in Mexican Spanish is described: a morphological dictionary and a semantic dictionary. These were created from two sources: a corpus of albures (drawn from “Antología del albur” book and a Mexican slang dictionary (“El chilangonario”. The morphological dictionary consists of 410 forms of words that corresponds to 350 lemmas. The semantic dictionary consists of 27 synsets that are associated to lemmas of morphological dictionary. Since both resources are based on Freeling library, they are easy to implement for tasks in Natural Language Processing. The motivation for this work comes from the need to address problems such as double entendre and computational humour. The usefulness of these disciplines has been discussed many times and it has been shown that they have a direct impact on user interfaces and, mainly, in human-computer interaction. This work aims to promote that the scientific community generates more resources about informal language in Spanish and other languages.

  3. Psycholinguistic and Neurolinguistic Investigations of Scalar Implicature

    Science.gov (United States)

    Politzer-Ahles, Stephen

    2013-01-01

    The present study examines the representation and composition of meaning in scalar implicatures. Scalar implicature is the phenomenon whereby the use of a less informative term (e.g., "some") is inferred to mean the negation of a more informative term (e.g., to mean "not all"). The experiments reported here investigate how the…

  4. Neurolinguistics: structural plasticity in the bilingual brain.

    Science.gov (United States)

    Mechelli, Andrea; Crinion, Jenny T; Noppeney, Uta; O'Doherty, John; Ashburner, John; Frackowiak, Richard S; Price, Cathy J

    2004-10-14

    Humans have a unique ability to learn more than one language--a skill that is thought to be mediated by functional (rather than structural) plastic changes in the brain. Here we show that learning a second language increases the density of grey matter in the left inferior parietal cortex and that the degree of structural reorganization in this region is modulated by the proficiency attained and the age at acquisition. This relation between grey-matter density and performance may represent a general principle of brain organization.

  5. Neurolinguistic Studies of Reading in Chinese

    Science.gov (United States)

    Tzeng, Ovid J. L.; Lee, Chia Ying; Lee, Jun Ren; Wu, Denise H.; Lee, Rose R.-W.; Hung, Daisy L.

    2017-01-01

    Using the Chinese writing system, which is unique with respect to the composition of each character in terms of its graphic shape, as an example, this chapter addresses the neurobiological underpinnings of reading and writing and how these brain circuits are used in different languages.

  6. A Minimal Neurolinguistic Model and Its Lessons

    Science.gov (United States)

    Gordon, Barry

    1985-01-01

    Impairments in object naming have contributed to a view held in Neurology that many higher brain functions can be understood as the result of sequential stages of processing connected by limited-channel pathways. However, this standard model cannot readily account for some specific types of impairments, nor for important variables such as speed. We reinterpreted the classic functional/neuroanatomic stages as examples of distributed, parallel processing in neural networks with massively parallel interconnections. Simulated “lesions” between the stages of this model could reproduce the impairments of real patients with such (presumed) lesions. Such models have to be strongly considered in understanding higher cerebral function and its disorders; empirical testing and future directions will be discussed.

  7. Neurolinguistic & psycholinguistic investigations on evidentiality in Turkish

    NARCIS (Netherlands)

    Arslan, Seckin

    2016-01-01

    Evidentialiteit is het linguïstisch uitdrukken van informatiebronnen die markeren hoe de spreker van een gebeurtenis afweet. In het Turks zijn er twee manieren om gebeurtenissen uit het verleden uit te drukken: de directe (-dI) of de indirecte evidentiële (-mIș) vorm moet als suffix worden

  8. Foreign Accent Syndrome: A Neurolinguistic Analysis

    NARCIS (Netherlands)

    Keulen, Stefanie Agnes Marino Theo

    2017-01-01

    Foreign Accent Syndrome, in het Nederlands ook wel het "buitenlandsaccentsyndroom" genoemd, is een motorische spraakstoornis waardoor patiënten hun moedertaal gaan spreken met een accent dat buitenlands klinkt in de oren van luisteraars. In dit proefschrift geven we een duidelijke neurolinguïstische

  9. A neurolinguistic model of grammatical construction processing.

    Science.gov (United States)

    Dominey, Peter Ford; Hoen, Michel; Inui, Toshio

    2006-12-01

    One of the functions of everyday human language is to communicate meaning. Thus, when one hears or reads the sentence, "John gave a book to Mary," some aspect of an event concerning the transfer of possession of a book from John to Mary is (hopefully) transmitted. One theoretical approach to language referred to as construction grammar emphasizes this link between sentence structure and meaning in the form of grammatical constructions. The objective of the current research is to (1) outline a functional description of grammatical construction processing based on principles of psycholinguistics, (2) develop a model of how these functions can be implemented in human neurophysiology, and then (3) demonstrate the feasibility of the resulting model in processing languages of typologically diverse natures, that is, English, French, and Japanese. In this context, particular interest will be directed toward the processing of novel compositional structure of relative phrases. The simulation results are discussed in the context of recent neurophysiological studies of language processing.

  10. Russian and Chinese Information Warfare: Theory and Practice

    Science.gov (United States)

    2004-06-01

    Integral neurolinguistic programming •Placing essential programs into the conscious or sub- conscious mind •Subconscious suggestions that modify human...Generators of special rays •Optical systems • Neurolinguistic programming •Computer psychotechnology •The mass media •Audiovisual effects •Special effects

  11. 47 CFR Appendix to Part 216 - NCS Directives

    Science.gov (United States)

    2010-10-01

    ... Telecommunications Program (NLP) Funding NCS Directive 3-1—Telecommunications Operations—Telecommunications Service... Program (NLP) Funding,” November 30, 1987. c. “National Security Emergency Preparedness (NSEP.... Definitions. a. The National Level NSEP Telecommunications Program (NLP). Those NSEP telecommunications...

  12. The Humanistic Psychology Movement and the Teaching of Chemistry.

    Science.gov (United States)

    Battino, Rubin

    1983-01-01

    Describes how several areas of humanistic psychology can be applied to college level chemistry in particular and teaching in general, focusing on confluent education in chemistry and neurolinguistic programing (including representational systems, anchoring, and neurolinguistic programing strategies). Comments on the author's participation in the…

  13. Infusing Counseling Skills in Test Interpretation.

    Science.gov (United States)

    Rawlins, Melanie E.; And Others

    1991-01-01

    Presents an instructional model based on Neurolinguistic Programming that links counseling student course work in measurement and test interpretation with counseling techniques and theory. A process incorporating Neurolinguistic Programming patterns is outlined for teaching graduate students the counseling skills helpful in test interpretation.…

  14. A Semi-Infinite Programming based algorithm for determining T-optimum designs for model discrimination.

    Science.gov (United States)

    Duarte, Belmiro P M; Wong, Weng Kee; Atkinson, Anthony C

    2015-03-01

    T-optimum designs for model discrimination are notoriously difficult to find because of the computational difficulty involved in solving an optimization problem that involves two layers of optimization. Only a handful of analytical T-optimal designs are available for the simplest problems; the rest in the literature are found using specialized numerical procedures for a specific problem. We propose a potentially more systematic and general way for finding T-optimal designs using a Semi-Infinite Programming (SIP) approach. The strategy requires that we first reformulate the original minimax or maximin optimization problem into an equivalent semi-infinite program and solve it using an exchange-based method where lower and upper bounds produced by solving the outer and the inner programs, are iterated to convergence. A global Nonlinear Programming (NLP) solver is used to handle the subproblems, thus finding the optimal design and the least favorable parametric configuration that minimizes the residual sum of squares from the alternative or test models. We also use a nonlinear program to check the global optimality of the SIP-generated design and automate the construction of globally optimal designs. The algorithm is successfully used to produce results that coincide with several T-optimal designs reported in the literature for various types of model discrimination problems with normally distributed errors. However, our method is more general, merely requiring that the parameters of the model be estimated by a numerical optimization.

  15. Optimal UAS Assignments and Trajectories for Persistent Surveillance and Data Collection from a Wireless Sensor Network

    Science.gov (United States)

    2015-12-24

    40 NLP Non-Linear Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 GPOPS-II General Purpose...Horn says, “this method removes the need for col- location and thus reduces the Non-Linear Program ( NLP ) size [41].” The method has been extended to...determined outside the NLP and then quickly queried in the NLP for path constraint evaluation [105].” Given the x and y position coordinates of the UAS

  16. A Nonlinear Model Predictive Control Algorithm for Obstacle Avoidance in Autonomous Ground Vehicles within Unknown Environments

    Science.gov (United States)

    2015-04-24

    achieved by formulating the obstacle avoidance problem into an optimal control problem (OCP), which is then converted into a nonlinear programming ( NLP ...time OCP is transcribed into to a nonlinear programming ( NLP ) problem using a direct method called hp-pseudospectral method [29], [30], [31]. Second...the resulting NLP problem is solved using the interior point method [32]. The hp-pseudospectral method discretizes a continuous-time OCP into an NLP

  17. HYPNOTEACHING IN HISTORY LESSON

    Directory of Open Access Journals (Sweden)

    Agus Budianto

    2017-07-01

    Full Text Available Abstract: Hypnoteaching in History Lesson. Historical learning is a science that can’t be separated in educating the younger generation. Through this lesson, teachers in secondary schools can provide the foundation of nationality through important events in the study of the social sciences. Many of the problems that occur in learning history, such as the boring and make sleepy. Everyone must have heard the term hypnosis, hypnotism, or hypnotherapy. Each person must also have a different view or understanding when hearing these terms. Hypnoteaching is one of the learning methods by using the art of communicating to influence learners. Hypnoteaching is a combination of five teaching-learning methods such as quantum learning, accelerate learning, power teaching, neuro-linguistic programming (NLP and hypnosis. Hypnoteaching can be done using informal hypnosis as well as formal hypnosis. Informal hypnosis is also called indirect hypnosis ie teachers can naturally make the Critical Area learners become no longer critical, through a very persuasive communication pattern. Here's what the teacher can do in Informal hypnosis: (1 get attention; (2 establishing Themes; (3 presenting the structure and regulations; (4 building relationships. If the learners are already comfortable and interested, the next step is to do a formal hypnosis before the lesson begins. Here are the steps that must be done: (1 Induction; (2 Deepening; (3 Deep level test; (4 Suggestion, and; (5 Termination.   Keywords: Historical learning, hypnoteaching, hypnosis, hypnotism, hypnotherapy, history Abstrak: Hipnoteaching dalam Pembelajaran Sejarah. Pelajaran sejarah tidak bisa dihilangkan dalam mendidik para generasi muda. Melalui pembelajaran ini, guru pada sekolah menengah pertama dapat memberikan pondasi rasa nasionalisme melalui peristiwa peristiwa penting dalam pelajaran ilmu pengetahuan social. Masalah yang sering muncul pada pembelajaran ini adalah kebosanan siswa dan

  18. THE MODEL OF MANAGEMENT OF THE INTERNAL MARKETING OF HIGHER EDUCATION INSTITUTE

    Directory of Open Access Journals (Sweden)

    Yuliya Viktorovna Naurazbaeva

    2015-12-01

    Full Text Available The main purpose of the research is the development of methods and models of management of the internal marketing of a higher education institute based on complex approach that includes strategic management methods and staff marketing and also technologies of Neuro-Linguistic Programming (NLP.Method or methodology of the research. Adapted models and methods of Neuro-Linguistic Programming, strategic management and marketing to management of marketing of the university which are presented as a complex of models that are reveling through the interrelation «external labor-market – higher education institute – internal labor-market».Results:1. The mechanism of management of the internal marketing of higher education institute based on the interrelation «external labor – market – higher education institute – internal labor-market» is offered that assumes solving problem of miscomparison between market conditions, university’s opportunities and demands of an employee of this educational institute.2. Methodical bases of formation of NLP-model that coordinates the requirements of labor collective as internal consumers of the educational service and needs of higher education institute in order to provide high quality services at all stages of creation and realization of an educational service are developed.3. The infological model of construction and choosing the strategy of the internal marketing of educational institute is presented.Practical implications. The received results can be used in practical management of higher education institute when forming the strategy of the internal marketing taking into account the specific features of concrete university.

  19. The 16th IFAC Workshop on Control Applications of Optimization

    Science.gov (United States)

    2015-10-09

    infinite optimal control problem is transformed to finite dimensional Nonlinear Programming Problem ( NLP ) (Betts, 1998) . The resulting NLP can be...solved using state-of-the-art structure exploit- ing NLP solvers . This enables easier handling of inequality path constraints in comparison to...1, direct opt imal control methods and hence NLP solvers shall be used as optimizat ion solvers. Direct methods use a finite dimensional control

  20. Program specialization

    CERN Document Server

    Marlet, Renaud

    2013-01-01

    This book presents the principles and techniques of program specialization - a general method to make programs faster (and possibly smaller) when some inputs can be known in advance. As an illustration, it describes the architecture of Tempo, an offline program specializer for C that can also specialize code at runtime, and provides figures for concrete applications in various domains. Technical details address issues related to program analysis precision, value reification, incomplete program specialization, strategies to exploit specialized program, incremental specialization, and data speci

  1. TRIANGULATION OF METHODS OF CAREER EDUCATION

    Directory of Open Access Journals (Sweden)

    Marija Turnsek Mikacic

    2015-09-01

    Full Text Available This paper is an overview of the current research in the field of career education and career planning. Presented results constitute a model based on the insight into different theories and empirical studies about career planning as a building block of personal excellence. We defined credibility, transferability and reliability of the research by means of triangulation. As sources of data of triangulation we included essays of participants of education and questionnaires. Qualitative analysis represented the framework for the construction of the paradigmatic model and the formulation of the final theory. We formulated a questionnaire on the basis of our own experiences in the area of the education of individuals. The quantitative analysis, based on the results of the interviews, confirms the following three hypotheses: The individuals who elaborated a personal career plan and acted accordingly, changed their attitudes towards their careers and took control over their lives; in addition, they achieved a high level of self-esteem and self-confidence, in tandem with the perception of personal excellence, in contrast to the individuals who did not participate in career education and did not elaborate a career plan. We used the tools of NLP (neurolinguistic programming as an additional technique at learning.

  2. Parenting Programs

    Directory of Open Access Journals (Sweden)

    Juan Carlos Martín-Quintana

    2010-01-01

    Full Text Available This paper was aimed at emphasizing the importance of using parenting programs to promote parental competences. There is a need for this support taking into account the complexity of the parenting task in our modern societies. Following the European recommendation on positive parenting, those parenting programs are considered important measures to support parents in their educational role. Forward, several generations of parenting programs at the international context were briefly described and some examples of programs within the national context, as well. This paper provides some reflection on three models of parental education, and shows the results of an experiential parenting programs addressed to parents in psychosocial risk situation in two Spanish communities. A new program “Crecer felices en familia”, still in the implementation phase, was also described. As a conclusion, the paper emphasized the importance of evaluating programs in order to know more about their efficacy and to improve the way of implementation in real settings.

  3. Material Programming

    DEFF Research Database (Denmark)

    Vallgårda, Anna; Boer, Laurens; Tsaknaki, Vasiliki

    2017-01-01

    , and color, but additionally being capable of sensing, actuating, and computing. Indeed, computers will not be things in and by themselves, but embedded into the materials that make up our surroundings. This also means that the way we interact with computers and the way we program them, will change....... Consequently we ask what the practice of programming and giving form to such materials would be like? How would we be able to familiarize ourselves with the dynamics of these materials and their different combinations of cause and effect? Which tools would we need and what would they look like? Will we program...... these computational composites through external computers and then transfer the code them, or will the programming happen closer to the materials? In this feature we outline a new research program that floats between imagined futures and the development of a material programming practice....

  4. Effective Programming

    DEFF Research Database (Denmark)

    Frost, Jacob

    To investigate the use of VTLoE as a basis for formal derivation of functional programs with effects. As a part of the process, a number of issues central to effective formal programming are considered. In particular it is considered how to develop a proof system suitable for pratical reasoning......, how to implement this system in the generic proof assistant Isabelle and finally how to apply the logic and the implementation to programming....

  5. Program Fullerene

    DEFF Research Database (Denmark)

    Wirz, Lukas; Peter, Schwerdtfeger,; Avery, James Emil

    2013-01-01

    Fullerene (Version 4.4), is a general purpose open-source program that can generate any fullerene isomer, perform topological and graph theoretical analysis, as well as calculate a number of physical and chemical properties. The program creates symmetric planar drawings of the fullerene graph......-Fowler, and Brinkmann-Fowler vertex insertions. The program is written in standard Fortran and C++, and can easily be installed on a Linux or UNIX environment....

  6. Programming Interactivity

    CERN Document Server

    Noble, Joshua

    2009-01-01

    Make cool stuff. If you're a designer or artist without a lot of programming experience, this book will teach you to work with 2D and 3D graphics, sound, physical interaction, and electronic circuitry to create all sorts of interesting and compelling experiences -- online and off. Programming Interactivity explains programming and electrical engineering basics, and introduces three freely available tools created specifically for artists and designers: Processing, a Java-based programming language and environment for building projects on the desktop, Web, or mobile phonesArduino, a system t

  7. Programming F#

    CERN Document Server

    Smith, Chris

    2009-01-01

    Why learn F#? This multi-paradigm language not only offers you an enormous productivity boost through functional programming, it also lets you develop applications using your existing object-oriented and imperative programming skills. With Programming F#, you'll quickly discover the many advantages of Microsoft's new language, which includes access to all the great tools and libraries of the .NET platform. Learn how to reap the benefits of functional programming for your next project -- whether it's quantitative computing, large-scale data exploration, or even a pursuit of your own. With th

  8. Computer Programs.

    Science.gov (United States)

    Anderson, Tiffoni

    This module provides information on development and use of a Material Safety Data Sheet (MSDS) software program that seeks to link literacy skills education, safety training, and human-centered design. Section 1 discusses the development of the software program that helps workers understand the MSDSs that accompany the chemicals with which they…

  9. Choreographic Programming

    DEFF Research Database (Denmark)

    Montesi, Fabrizio

    , as they offer a concise view of the message flows enacted by a system. For this reason, in the last decade choreographies have been used in the development of programming languages, giving rise to a programming paradigm that in this dissertation we refer to as Choreographic Programming. Recent studies show...... endpoint described in a choreography can then be automatically generated, ensuring that such implementations are safe by construction. However, current formal models for choreographies do not deal with critical aspects of distributed programming, such as asynchrony, mobility, modularity, and multiparty...... sessions; it remains thus unclear whether choreographies can still guarantee safety when dealing with such nontrivial features. This PhD dissertation argues for the suitability of choreographic programming as a paradigm for the development of safe distributed systems. We proceed by investigating its...

  10. Combining Different NLP Methods for HUMINT Report Analysis

    Science.gov (United States)

    2009-10-01

    JENGE, Silverius KAWALETZ, Ulrich SCHADE Fraunhofer-Institut für Kommunikation , Informationsverarbeitung und Ergonomie (FKIE) Neuenahrer Str. 20 53343...ES) Fraunhofer-Institut für Kommunikation , Informationsverarbeitung und Ergonomie (FKIE) Neuenahrer Str. 20 53343 Wachtberg-Werthhoven Germany 8

  11. Methodology to develop and evaluate a semantic representation for NLP.

    Science.gov (United States)

    Irwin, Jeannie Y; Harkema, Henk; Christensen, Lee M; Schleyer, Titus; Haug, Peter J; Chapman, Wendy W

    2009-11-14

    Natural language processing applications that extract information from text rely on semantic representations. The objective of this paper is to describe a methodology for creating a semantic representation for information that will be automatically extracted from textual clinical records. We illustrate two of the four steps of the methodology in this paper using the case study of encoding information from dictated dental exams: (1) develop an initial representation from a set of training documents and (2) iteratively evaluate and evolve the representation while developing annotation guidelines. Our approach for developing and evaluating a semantic representation is based on standard principles and approaches that are not dependent on any particular domain or type of semantic representation.

  12. CLOSED DOMAIN QUESTION ANSWERING SYSTEM USING NLP TECHNIQUES

    OpenAIRE

    Sweta P. Lende*; M. M. Raghuwanshi

    2016-01-01

    Question Answering (QA) system in information retrieval is a task of automatically answering a correct answer to the questions asked by human in natural language using either a pre-structured database or a collection of natural language documents. It presents only the requested information instead of searching full documents like search engine. This paper presents the implementation methods and experimental result with analysis for closed domain QA System which handle only documents related t...

  13. NLP viestinnän lähestymistapana

    OpenAIRE

    Malmelin, Karoliina

    2001-01-01

    Endast sammandrag. Inbundna avhandlingar kan sökas i Helka-databasen (http://www.helsinki.fi/helka). Elektroniska kopior av avhandlingar finns antingen öppet på nätet eller endast tillgängliga i bibliotekets avhandlingsterminaler. Only abstract. Paper copies of master’s theses are listed in the Helka database (http://www.helsinki.fi/helka). Electronic copies of master’s theses are either available as open access or only on thesis terminals in the Helsinki University Library. Vain tiivi...

  14. Efficient Encoding of Inflection Rules in NLP Systems

    Directory of Open Access Journals (Sweden)

    Péter BARABÁSS

    2012-12-01

    Full Text Available The grammatical parsing unit is a core module in natural language processing engines. This unit determines the grammatical roles of the incoming words and it converts the sentences into semantic models. A special grammar rule in agglutinative languages is the inflection rule. The traditional, automata-based parsers are usually not very effective in the parsing of inflection transformations. The paper presents implementation alternatives and compares them from the viewpoint of time efficiency and accuracy. The prototype system was tested with examples from Hungarian.

  15. Designing Rules for Accounting Transaction Identification based on Indonesian NLP

    Science.gov (United States)

    Iswandi, I.; Suwardi, I. S.; Maulidevi, N. U.

    2017-03-01

    Recording accounting transactions carried out by the evidence of the transactions. It can be invoices, receipts, letters of intent, electricity bill, telephone bill, etc. In this paper, we proposed design of rules to identify the entities located on the sales invoice. There are some entities identified in a sales invoice, namely : invoice date, company name, invoice number, product id, product name, quantity and total price. Identification this entities using named entity recognition method. The entities generated from the rules used as a basis for automation process of data input into the accounting system.

  16. Improving passage retrieval in question answering using NLP

    NARCIS (Netherlands)

    Tiedemann, J; Bento, C; Cardoso, A; Dias, G

    2005-01-01

    This paper describes an approach for the integration of linguistic information in passage retrieval in an open-source question answering system for Dutch. Annotation produced by the wide-coverage dependency parser Alpino is stored in multiple index layers to be matched with natural language question

  17. Programming Python

    CERN Document Server

    Lutz, Mark

    2011-01-01

    If you've mastered Python's fundamentals, you're ready to start using it to get real work done. Programming Python will show you how, with in-depth tutorials on the language's primary application domains: system administration, GUIs, and the Web. You'll also explore how Python is used in databases, networking, front-end scripting layers, text processing, and more. This book focuses on commonly used tools and libraries to give you a comprehensive understanding of Python's many roles in practical, real-world programming. You'll learn language syntax and programming techniques in a clear and co

  18. Neurolinguistic Foundations to Methods of Teaching a Second Language.

    Science.gov (United States)

    Walsh, Terrence M.; Diller, Karl C.

    Applied linguistic theory is examined in light of neuroscientific knowledge, especially in regard to the structure and function of the cerebral cortex, in order to illuminate the process and methods of teaching or learning language. Wernicke's Area and Broca's Area are parts of the brain that have been associated with language function.…

  19. Birdsong neurolinguistics: songbird context-free grammar claim is premature.

    Science.gov (United States)

    Beckers, Gabriël J L; Bolhuis, Johan J; Okanoya, Kazuo; Berwick, Robert C

    2012-02-15

    There are remarkable behavioral, neural, and genetic similarities between song learning in songbirds and speech acquisition in human infants. Previously, we have argued that this parallel cannot be extended to the level of sentence syntax. Although birdsong can indeed have a complex structure, it lacks the combinatorial complexity of human language syntax. Recently, this conclusion has been challenged by a report purporting to show that songbirds can learn so-called context-free syntactic rules and then use them to discriminate particular syllable patterns. Here, we demonstrate that the design of this study is inadequate to draw such a conclusion, and offer alternative explanations for the experimental results that do not require the acquisition and use of context-free grammar rules or a grammar of any kind, only the simpler hypothesis of acoustic similarity matching. We conclude that the evolution of vocal learning involves both neural homologies and behavioral convergence, and that human language reflects a unique cognitive capacity.

  20. Neurolinguistics of Linguistic Perseveration: Evidences from Clinical Population

    Science.gov (United States)

    Rao, Prema K. S.

    2007-01-01

    It is generally well known that linguistic perseveration is a common symptom in individuals with brain damage and that its manifestation may be at the phonological, syntactic and/or semantic levels. The influence of perseveratory behavior on a subject's response to test stimuli and in therapeutic process has triggered the interests of the speech…

  1. About the neurolinguistics of the implicatures: abstract of a study

    Directory of Open Access Journals (Sweden)

    Juliano Luís Fontanari

    1989-06-01

    Full Text Available Taking into account recent data on linguistics of production and comprehension in aphasia, a protocol was executed including the several types of implicatures. The protocol was applied to 90 subjects classified according to the localization of cerebral lesions, as shown by CT. Results are discussed in report to clinical manifestations of brain lesions, as aphasia, apraxia, agnosia, and intelligence and pragmatics disturbances. Discussion supports the impression that there is a mechanism that correlates extra-linguistics contexts with the 'said' at the right hemisphere.

  2. Neurolinguistics and Second Language Teaching: A View from the Crossroads

    Science.gov (United States)

    Rastelli, Stefano

    2018-01-01

    The topic of this article is the link between research on the neurocognition of the teaching--acquisition interface and research on second language teaching. This recent scientific enterprise investigates whether and how different aspects of second language instruction may change both the anatomy and the functioning of an adult learner's brain…

  3. [Tributes to Macdonald Critchley and his achievements in neurolinguistics].

    Science.gov (United States)

    Hung, Tsu-Pei

    2008-06-01

    Macdonald Critchley, a world renowned neurologist, is best remembered as the person who challenged to solve the mystery and enigma of higher cerebral functions. He was the author of over 200 published articles and 20 books on neurology including his pioneer work on developmental dyslexia, the parietal lobe, cerebral hemisphere dominance and aphasiology. He also published articles on migraine, epilepsy, dementia, visual perseveration, anterior cerebral artery syndromes, indifference to pain, sleep disorders, movement disorders, and myotonia. He was very erudite and talented in linguistics; his interests were broad and eclectic. He wrote extensively on non-medical topics, such as plays, horror stories, mythology, and biographies of distinguished neuroscientists, philosophers or artists. His articles were written in the elegant prose style with thorough reference citations and extensive reviews of the literature worldwide. He was born in Bristol in 1900. From an early age, he was fascinated with the functioning brain and retained a life-long interest in languages. He was appointed to the Consultant staff of the National Hospital, Queen Square, and to King's College Hospital at the age of 27, and was elected to become FRCP at 30. He was Dean of the Institute of Neurology from 1948 to 1953. When I was studying advanced neurology at Queen Square in 1960-1961, I was fascinated by his outstanding lectures on Huntington's Disease and Non-verbal Communication. Although he did not read the manuscripts and used only a few slides for illustrations in his lectures, he could describe the details of historical accounts and relevant figures. He was an altruistic, instructive teacher with keen attention to responses from the audience. His clinical demonstrations, teaching rounds and tutorials were hugely popular among postgraduate students from all over the world. He emphasized the importance of shrewd observation and careful history taking in neurological practice. Macdonald Critchley was President of the World Federation of Neurology (1965-1973) and Editor of Journal of the Neurological Sciences. I met him at the 2nd Asian and Oceanian Congress of Neurology held in Melbourne in 1967. He was interested to know more about aphasia and dyslexia among people speaking and reading Chinese. He kindly invited me to speak on 'Linguistic Implications of Chinese Characters' at the meeting of the Research Group on Developmental Dyslexia in Dallas. Critchley's prominent achievements in teaching, writings and research on neurology derived from his creative thinking, powers of shrewd observation, wide knowledge of literature, and indefatigable assiduity in scientific pursuits. He died peacefully at home at the age of 97 and entered the pantheon of distinguished neuroscientists of the 20th century.

  4. [Neurolinguistic analysis of a case of pure agraphia].

    Science.gov (United States)

    Petrillo, S; Poli, R; Piccirilli, M

    1990-01-01

    A patient with a pure acquired dysgraphia is reported. The pattern of the patient's performance is discussed in relation to current functional models of writing. The case may be interpreted by assuming a selective impairment to the graphemic buffer.

  5. Intraoperative mapping of language functions: a longitudinal neurolinguistic analysis.

    Science.gov (United States)

    Ilmberger, Josef; Ruge, Maximilian; Kreth, Friedrich-Wilhelm; Briegel, Josef; Reulen, Hans-Juergen; Tonn, Joerg-Christian

    2008-10-01

    This prospective longitudinally designed study was conducted to evaluate language functions pre- and postoperatively in patients who underwent microsurgical treatment of tumors in close proximity to or within language areas and to detect those patients at risk for a postoperative aphasic disturbance. Between 1991 and 2005, 153 awake craniotomies with subsequent cortical mapping of language functions were performed in 149 patients. Language functions were assessed using a standardized test battery. Risk factors were obtained from multivariate logistic regression models. Language mapping was able to be performed in all patients, and complete tumor resection was achieved in 48.4%. Within 21 days after surgery a new language deficit (aphasic disturbance) was observed in 41 (32%) of the 128 cases without preoperative deficits. There were a total of 60 cases involving postoperative aphasic disturbances, including cases both with and without preoperative disturbances. Risk factors for postoperative aphasic disturbance were preoperative aphasia (p40 years, p<0.02) and preoperative aphasia (p<0.001). Every attempt should be undertaken to preserve language-relevant areas intraoperatively, even when they are located within the tumor. New postoperative deficits resolve in the majority of patients, which may be a result of cortical mapping as well as functional reorganization.

  6. [Neurolinguistic aspects in autism spectrum disorders. Neuroanatomical and functional relations].

    Science.gov (United States)

    Palau-Baduell, M; Valls-Santasusana, A; Salvadó-Salvadó, B

    2010-03-03

    Impairments in language and communication are a defining feature of autism spectrum disorders. There is significant variability in linguistic abilities in autism spectrum disorders. They have difficulties with certain aspects of language such as semantics functions, syntax, prosody and phonology, although the most evident language deficits concern to pragmatics functioning. These language difficulties can cause serious problems in social interaction. The neural bases underlying this failure to develop language are unknown. Several functional and structural imaging studies have identified irregularities in language-related regions in autism spectrum disorders, such as morphometric differences in Broca's area and Wernicke's area, and patterns of reduced or reversed laterality in frontal and temporal cortex. There is also decreased functional connectivity between anterior and posterior language regions.

  7. On the neurolinguistic nature of language abnormalities in Huntington's disease.

    Science.gov (United States)

    Wallesch, C W; Fehrenbach, R A

    1988-03-01

    Spontaneous language of 18 patients suffering from Huntington's disease and 15 dysarthric controls suffering from Friedreich's ataxia were investigated. In addition, language functions in various modalities were assessed with the Aachen Aphasia Test (AAT). The Huntington patients exhibited deficits in the syntactical complexity of spontaneous speech and in the Token Test, confrontation naming, and language comprehension subtests of the AAT, which are interpreted as resulting from their dementia. Errors affecting word access mechanisms and production of syntactical structures as such were not encountered.

  8. Neurolinguistic differentiation of children with subtypes of dyslexia.

    Science.gov (United States)

    Masutto, C; Bravar, L; Fabbro, F

    1994-10-01

    A detailed analysis of the types of childhood dyslexia proposed by Boder (1973) and Bakker (1990) revealed characteristic patterns of organization of intellectual functions, of hemispheric specialization, and of reading errors in right-handed children with dyslexia. Children with L-type dyslexia (10 subjects) evidenced a large number of reading errors (e.g., substitutions of nouns and verbs), low scores in verbal short-term memory, and right-ear advantage (REA) in dichotic listening. Children with P-dyslexia (18 subjects) evidenced few reading errors, a short attention span, low performance in visual-motor coordination (WISC-R coding), and an absence of REA in dichotic listening. Children with M-type dyslexia (10 subjects) showed numerous reading errors (e.g., substitution of syllables and words), low performance in visual-motor coordination items (coding), and REA in dichotic listening.

  9. Neurolinguistic processing when the brain matures without language.

    Science.gov (United States)

    Mayberry, Rachel I; Davenport, Tristan; Roth, Austin; Halgren, Eric

    2018-02-01

    The extent to which development of the brain language system is modulated by the temporal onset of linguistic experience relative to post-natal brain maturation is unknown. This crucial question cannot be investigated with the hearing population because spoken language is ubiquitous in the environment of newborns. Deafness blocks infants' language experience in a spoken form, and in a signed form when it is absent from the environment. Using anatomically constrained magnetoencephalography, aMEG, we neuroimaged lexico-semantic processing in a deaf adult whose linguistic experience began in young adulthood. Despite using language for 30 years after initially learning it, this individual exhibited limited neural response in the perisylvian language areas to signed words during the 300-400 ms temporal window, suggesting that the brain language system requires linguistic experience during brain growth to achieve functionality. The present case study primarily exhibited neural activations in response to signed words in dorsolateral superior parietal and occipital areas bilaterally, replicating the neural patterns exhibited by two previously case studies who matured without language until early adolescence (Ferjan Ramirez N, Leonard MK, Torres C, Hatrak M, Halgren E, Mayberry RI. 2014). The dorsal pathway appears to assume the task of processing words when the brain matures without experiencing the form-meaning network of a language. Copyright © 2018 Elsevier Ltd. All rights reserved.

  10. Development of the Lurian approach: a cultural neurolinguistic perspective.

    Science.gov (United States)

    Kotik-Friedgut, Bella

    2006-03-01

    This article presents a discussion of the principle of extracortical organization of higher mental functions and its significance for the development of contemporary neuropsychology. The role of external factors (stimulus-mediator, symbol) in establishing functional connections between various brain systems is, in principle, universal. However, inasmuch as differing mediators and means, or significantly different details within them (direction of writing, orientation by maps or by the behavior of sea birds, etc.) may and in fact do develop in different cultures, neuropsychological analysis must take into account cross-cultural differences. Diagnostic tools must also be adapted to differing cultural contexts. The efficacy of this principle for the analysis of bilingual aphasia and of mental organization of speech, including the effect of acquisition of literacy in native language, is demonstrated. The importance of this principle for the development of new directions in applied neuropsychology is also discussed.

  11. Programming Python

    National Research Council Canada - National Science Library

    Lutz, Mark

    2006-01-01

    ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 3 3 8 9 15 17 20 22 2. A Sneak Preview "Programming Python: The Short Story" The Task Step 1: Representing Records Step 2: Storing Records Persistently Step 3...

  12. Linear programming

    CERN Document Server

    Solow, Daniel

    2014-01-01

    This text covers the basic theory and computation for a first course in linear programming, including substantial material on mathematical proof techniques and sophisticated computation methods. Includes Appendix on using Excel. 1984 edition.

  13. Systematic Computer-Aided Framework for Sustainable Chemical Product Design

    DEFF Research Database (Denmark)

    Cignitti, Stefano; Zhang, Lei; Kalakul, Sawitree

    into a sub-set of programs to manage the complexity: mixed-integer linear program (MILP) for molecular generation, linear program (LP) for property constraints, non-linear program (NLP) for mixture/blend property constraints, and NLP for process constraints and objective function. This approach ensures...

  14. Army Programs: Army Energy Program

    Science.gov (United States)

    1997-02-03

    the Energy Program. o Expands the responsibilities of the Assistant Chief of Staff for Installation Management (para 1-4). o Includes ridesharing as...not been highlighted. Summary. This regulation establishes poli- cies, procedures, and responsibilities for the Army Energy Program. Applicability ...Energy Technology Service (FETS) • 3–13, page 6 Energy Surveys • 3–14, page 6 Army Energy Awareness Seminars • 3–15, page 6 Army ridesharing • 3–16

  15. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Program Commission on Cancer National Accreditation Program for Breast Centers National Cancer Database National Accreditation Program for Rectal Cancer Oncology Medical Home Accreditation Program Stereotactic Breast Biopsy Accreditation Program Cancer Programs Staff Information Children's ...

  16. Programming Algol

    CERN Document Server

    Malcolme-Lawes, D J

    2014-01-01

    Programming - ALGOL describes the basics of computer programming using Algol. Commands that could be added to Algol and could increase its scope are described, including multiplication and division and the use of brackets. The idea of labeling or naming a command is also explained, along with a command allowing two alternative results. Most of the important features of Algol syntax are discussed, and examples of compound statements (that is, sets of commands enclosed by a begin ... end command) are given.Comprised of 11 chapters, this book begins with an introduction to the digital computer an

  17. Programming Interactivity

    CERN Document Server

    Noble, Joshua

    2012-01-01

    Ready to create rich interactive experiences with your artwork, designs, or prototypes? This is the ideal place to start. With this hands-on guide, you'll explore several themes in interactive art and design-including 3D graphics, sound, physical interaction, computer vision, and geolocation-and learn the basic programming and electronics concepts you need to implement them. No previous experience is necessary. You'll get a complete introduction to three free tools created specifically for artists and designers: the Processing programming language, the Arduino microcontroller, and the openFr

  18. ICD programming

    OpenAIRE

    Biffi, Mauro

    2014-01-01

    Background: Appropriate ICD programming is the key to prevent inappropriate shock delivery, that is closely associated to a negative patients' outcome. Methods: Review of the literature on ICD therapy to generate ICD programmings that can be applied to the broad population of ICD and CRT-D carriers. Results: Arrhythmia detection should occur with a detection time ranging 9″–12″ in the VF zone, and 15″–60″ in the VT zone. Discriminator should be applied at least up to 200 bpm. ATP therap...

  19. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Safety Conference Registry Login SCR Training and Testing Cancer Cancer Programs Cancer Programs Overview of Cancer Programs Cancer Programs News American Joint Committee on ...

  20. Program Proposal

    Science.gov (United States)

    Baskas, Richard S.

    2012-01-01

    A study was conducted to determine if a deficiency, or learning gap, existed in a particular working environment. To determine if an assessment was to be conducted, a program proposal would need to be developed to explore this situation. In order for a particular environment to react and grow with other environments, it must be able to take on…

  1. Sprego Programming

    Directory of Open Access Journals (Sweden)

    Maria Csernoch

    2015-02-01

    Full Text Available Spreadsheet management is a border-land between office applications and programming, however, it is rather communicated that spreadsheet is nothing more than an easily handled fun piece. Consequently, the complexity of spreadsheet handling, the unprepared end-users, their problem solving abilities and approaches do not match. To overcome these problems we have developed and introduced Sprego (Spreadsheet Lego. Sprego is a simplified functional programming language in spreadsheet environment, and such as can be used both as introductory language and the language of end-user programmers. The essence of Sprego is that we use as few and simple functions as possible and based on these functions build multilevel formulas. With this approach, similar to high level programming, we are able solve advanced problems, developing algorithmic skills, computational thinking. The advantage of Sprego is the simplicity of the language, when the emphasis is not on the coding but on the problem. Beyond that spreadsheets would provide real life problems with authentic data and tables which students are more interested in than the artificial environment and semi-authentic problems of high level programming languages.

  2. Constraint Programming versus Mathematical Programming

    DEFF Research Database (Denmark)

    Hansen, Jesper

    2003-01-01

    Constraint Logic Programming (CLP) is a relatively new technique from the 80's with origins in Computer Science and Artificial Intelligence. Lately, much research have been focused on ways of using CLP within the paradigm of Operations Research (OR) and vice versa. The purpose of this paper...

  3. Linear programming

    CERN Document Server

    Karloff, Howard

    1991-01-01

    To this reviewer’s knowledge, this is the first book accessible to the upper division undergraduate or beginning graduate student that surveys linear programming from the Simplex Method…via the Ellipsoid algorithm to Karmarkar’s algorithm. Moreover, its point of view is algorithmic and thus it provides both a history and a case history of work in complexity theory. The presentation is admirable; Karloff's style is informal (even humorous at times) without sacrificing anything necessary for understanding. Diagrams (including horizontal brackets that group terms) aid in providing clarity. The end-of-chapter notes are helpful...Recommended highly for acquisition, since it is not only a textbook, but can also be used for independent reading and study. —Choice Reviews The reader will be well served by reading the monograph from cover to cover. The author succeeds in providing a concise, readable, understandable introduction to modern linear programming. —Mathematics of Computing This is a textbook intend...

  4. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Inspiring Quality Initiative Resources Continuous Quality Improvement ACS Clinical Scholars in Residence AHRQ Safety Program for ISCR ... Advocacy Efforts Cancer Liaison Program Cancer Programs Conference Clinical Research Program Commission on Cancer National Accreditation Program ...

  5. Programming Pig

    CERN Document Server

    Gates, Alan

    2011-01-01

    This guide is an ideal learning tool and reference for Apache Pig, the open source engine for executing parallel data flows on Hadoop. With Pig, you can batch-process data without having to create a full-fledged application-making it easy for you to experiment with new datasets. Programming Pig introduces new users to Pig, and provides experienced users with comprehensive coverage on key features such as the Pig Latin scripting language, the Grunt shell, and User Defined Functions (UDFs) for extending Pig. If you need to analyze terabytes of data, this book shows you how to do it efficiently

  6. Programming Razor

    CERN Document Server

    Chadwick, Jess

    2011-01-01

    Take Razor for a test drive and discover first hand how this scripting syntax simplifies the way you create dynamic, data-driven websites. With this concise guide, you'll work with Razor syntax by building example websites with Microsoft WebMatrix and ASP.NET MVC. You'll quickly learn how Razor lets you combine code and content in a fluid and expressive manner on Windows-based servers. Programming Razor also explores components of the Razor API, and shows you how Razor templates are turned into rendered HTML. By the end of this book, you'll be able to create Razor-based websites with custom

  7. Numerical Nonlinear Robust Control with Applications to Humanoid Robots

    Science.gov (United States)

    2015-07-01

    transcribes a continuous-time optimal control problem directly into an equivalent nonlinear programming problem ( NLP ) [94]. This is done by...established approximate method. The use of collocation in optimal control is a a NLP problem, which can in turn, be converted to a sequential...equivalent condition to the first order KKT conditions of the NLP , which can be solved by a MCP solver such as KNITRO [134]. 4.4 Example - two-dimensional

  8. Geothermal Technologies Program Overview - Peer Review Program

    Energy Technology Data Exchange (ETDEWEB)

    Milliken, JoAnn [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2011-06-06

    This Geothermal Technologies Program presentation was delivered on June 6, 2011 at a Program Peer Review meeting. It contains annual budget, Recovery Act, funding opportunities, upcoming program activities, and more.

  9. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Accreditation Program Stereotactic Breast Biopsy Accreditation Program Cancer Programs Staff Information Children's Surgery Children's Surgery Children's Surgery Children's Surgery Verification ...

  10. Annotated Answer Set Programming

    OpenAIRE

    Straccia, Umberto

    2005-01-01

    We present Annotated Answer Set Programming, that extends the ex pressive power of disjunctive logic programming with annotation terms, taken from the generalized annotated logic programming framework.

  11. Functional Python programming

    CERN Document Server

    Lott, Steven

    2015-01-01

    This book is for developers who want to use Python to write programs that lean heavily on functional programming design patterns. You should be comfortable with Python programming, but no knowledge of functional programming paradigms is needed.

  12. Human Reliability Program Overview

    Energy Technology Data Exchange (ETDEWEB)

    Bodin, Michael

    2012-09-25

    This presentation covers the high points of the Human Reliability Program, including certification/decertification, critical positions, due process, organizational structure, program components, personnel security, an overview of the US DOE reliability program, retirees and academia, and security program integration.

  13. Vehicle Technologies Program Overview

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2006-09-05

    Overview of the Vehicle Technologies Program including external assessment and market view; internal assessment, program history and progress; program justification and federal role; program vision, mission, approach, strategic goals, outputs, and outcomes; and performance goals.

  14. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Quality Improvement Program About Standards Apply Participant Use Data File (PUF) Resources & FAQs Find a MBSAQIP Center ... Programs BleedingControl.org Trauma Quality Programs National Trauma Data Bank Trauma Quality Improvement Program Mentoring for Excellence ...

  15. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Overview of Cancer Programs Cancer Programs News American Joint Committee on Cancer Cancer Advocacy Efforts Cancer Liaison ... Validation Programs Accredited Education Institutes CME Accreditation CME Joint Providership Program Verification of Knowledge and Skills Resources ...

  16. Behavioral program synthesis with genetic programming

    CERN Document Server

    Krawiec, Krzysztof

    2016-01-01

    Genetic programming (GP) is a popular heuristic methodology of program synthesis with origins in evolutionary computation. In this generate-and-test approach, candidate programs are iteratively produced and evaluated. The latter involves running programs on tests, where they exhibit complex behaviors reflected in changes of variables, registers, or memory. That behavior not only ultimately determines program output, but may also reveal its `hidden qualities' and important characteristics of the considered synthesis problem. However, the conventional GP is oblivious to most of that information and usually cares only about the number of tests passed by a program. This `evaluation bottleneck' leaves search algorithm underinformed about the actual and potential qualities of candidate programs. This book proposes behavioral program synthesis, a conceptual framework that opens GP to detailed information on program behavior in order to make program synthesis more efficient. Several existing and novel mechanisms subs...

  17. NASA's educational programs

    Science.gov (United States)

    Brown, Robert W.

    1990-01-01

    The educational programs of NASA's Educational Affairs Division are examined. The problem of declining numbers of science and engineering students is reviewed. The various NASA educational programs are described, including programs at the elementary and secondary school levels, teacher education programs, and undergraduate, graduate, and university faculty programs. The coordination of aerospace education activities and future plans for increasing NASA educational programs are considered.

  18. An Intelligent Robot Programing

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Seong Yong

    2012-01-15

    This book introduces an intelligent robot programing with background of the begging, introduction of VPL, and SPL, building of environment for robot platform, starting of robot programing, design of simulation environment, robot autonomy drive control programing, simulation graphic. Such as SPL graphic programing graphical image and graphical shapes, and graphical method application, application of procedure for robot control, robot multiprogramming, robot bumper sensor programing, robot LRF sencor programing and robot color sensor programing.

  19. System programming languages

    OpenAIRE

    Šmit, Matej

    2016-01-01

    Most operating systems are written in the C programming language. Similar is with system software, for example, device drivers, compilers, debuggers, disk checkers, etc. Recently some new programming languages emerged, which are supposed to be suitable for system programming. In this thesis we present programming languages D, Go, Nim and Rust. We defined the criteria which are important for deciding whether programming language is suitable for system programming. We examine programming langua...

  20. Operations Program Executive

    Science.gov (United States)

    Fague, M. A.

    1982-01-01

    Ground Resource Operations Program executive (GROPE) is control program for binding system of programs into single, easily operated entity. It relieves user from complexity arising from decomposition of large application into number of interacting program units. System simplifies job control, data management, and recordkeeping for interacting programs.

  1. Lippincott Basic Reading Program.

    Science.gov (United States)

    Monterey Peninsula Unified School District, Monterey, CA.

    This program, included in "Effective Reading Programs...," serves 459 students in grades 1-3 at 15 elementary schools. The program employs a diagnostic-prescriptive approach to instruction in a nongraded setting through the use of the Lippincott Basic Reading program. When a child enters the program, he is introduced to a decoding…

  2. Structured Programming: An Introduction.

    Science.gov (United States)

    Moulton, Peter

    Designed for use by computer programming teachers, this booklet presents the concepts of structured programming and provides examples of how to implement this methodology, which provides a systematic way of organizing programs so that even large and complex programs are easier to understand and modify than unstructured programs. After a brief…

  3. The effect of career planning education

    Directory of Open Access Journals (Sweden)

    Marija Turnšek Mikačič

    2015-09-01

    Full Text Available Research Question (RQ: We employed a qualitative approach to study the effects of career planning education, perceiving it as an effective way to gain a deeper understanding of introductorily-organised career education. Purpose: We researched important areas to formulate a questionnaire for quantitative analysis. Method: We used a qualitative research approach in order to develop a theoretical framework for the exploration, interpretation and identification of the impact of education on career plans, on the changing attitudes towards careers, the raising of self-esteem and perception of personal growth. We used Neuro-linguistic programming as a tool to develop and achieve personal excellence within the career planning. Results: We constructed a paradigmatic model and developed the final theory. By means of qualitative analysis, we identified the elements of design criteria for the construction of the questionnaire; we measured the effects of education on career plans. Organization: The findings of the research will prove useful in personal management and career management in the process of planning and organizing the promotion of individuals within the organizations in accordance with the needs of those organizations. Originality: A career plan as a building block of personal growth, based on the model of career education with the in-built elements and tools of NLP, has been confirmed by the most recent studies in neuroscience. This represents a novelty, and, therefore, this study offers a genuine contribution, and is an indicator of contemporary knowledge, based on the results of the research. Limitations/Future Research: The model of career education and the results of this study open new directions for further research of the influence of career planning on the organisation of companies and their success, which is the phase of the study which was not carried out.

  4. Delivery mode and neonatal outcome after a trial of external cephalic version (ECV): a prospective trial of vaginal breech versus cephalic delivery.

    Science.gov (United States)

    Reinhard, Joscha; Sänger, Nicole; Hanker, Lars; Reichenbach, Lena; Yuan, Juping; Herrmann, Eva; Louwen, Frank

    2013-04-01

    To examine the delivery mode and neonatal outcome after a trial of external cephalic version (ECV) procedures. This is an interim analysis of an ongoing larger prospective off-centre randomised trial, which compares a clinical hypnosis intervention against neuro-linguistic programming (NLP) of women with a singleton breech foetus at or after 37(0/7) (259 days) weeks of gestation and normal amniotic fluid index. Main outcome measures were delivery mode and neonatal outcome. On the same day after the ECV procedure two patients (2 %), who had unsuccessful ECVs, had Caesarean sections (one due to vaginal bleeding and one due to pathological CTG). After the ECV procedure 40.4 % of women had cephalic presentation (n = 38) and 58.5 % (n = 55) remained breech presentation. One patient remained transverse presentation (n = 1; 1.1 %). Vaginal delivery was observed by 73.7 % of cephalic presentation (n = 28), whereas 26.3 % (n = 10) had in-labour Caesarean sections. Of those, who selected a trial of vaginal breech delivery, 42.4 % (n = 14) delivered vaginally and 57.6 % (n = 19) delivered via Caesarean section. There is a statistically significant difference between the rate of vaginal birth between cephalic presentation and trial of vaginal breech delivery (p = 0.009), however, no difference in neonatal outcome was observed. ECV is a safe procedure and can reduce not only the rate of elective Caesarean sections due to breech presentation but also the rate of in-labour Caesarean sections even if a trial of vaginal breech delivery is attempted.

  5. Energy Technology Programs: program summaries for 1979

    Energy Technology Data Exchange (ETDEWEB)

    1979-12-01

    The Energy Technology Programs in the BNL Department of Energy and Environment cover a broad range of activities, namely: electrochemical research, chemical energy storage, chemical heat pumps, solar technology, fossil technology, catalytic systems development, space-conditioning technology, and technical support/program management. Summaries of the individual tasks associated with these activities along with publications, significant accomplishments, and program funding levels are presented.

  6. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Trauma Quality Programs National Trauma Data Bank Trauma Quality Improvement Program Mentoring for Excellence in Trauma Surgery Advanced Trauma Life Support Verification, Review, and Consultation Program for Hospitals ...

  7. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... 2016 Annual Meeting Women's Committee Mentorship Program Outside Activities ACS Archives Contact Us Quality Programs Quality Programs ... Quality in Geriatric Surgery Project Project Goals and Activities Stakeholder Organizations Project Team Resources News Contact Us ...

  8. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Accreditation Program for Breast Centers About NAPBC Accreditation Education NAPBC Standards Cancer Programs News Quality in Geriatric ... 4 and Recertification SSR Login MIPS Resources and Education Quality and Safety Conference Trauma Trauma Programs Trauma ...

  9. New Parent Support Program

    Science.gov (United States)

    ... preparation and guidance. View More Search All Installation Program Directory Find programs and services at your local installation. View a directory of installations Select a program or service Enter the name of an installation ...

  10. National Toxicology Program

    Science.gov (United States)

    ... at NTP Study Types Nominations to the Testing Program Study Results & Research Projects Areas of Research Data & ... on for decisions that matter. The National Toxicology Program provides the scientific basis for programs, activities, and ...

  11. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Meeting Women's Committee Mentorship Program Outside Activities ACS Archives Contact Us Quality Programs Quality Programs Overview About ... The Hartford Consensus News Coverage Stop the Bleed Archives and History Archives and History Archives and History ...

  12. Stop smoking support programs

    Science.gov (United States)

    Smokeless tobacco - stop smoking programs; Stop smoking techniques; Smoking cessation programs; Smoking cessation techniques ... You can find out about smoking cessation programs from: Your ... Your employer Your local health department The National Cancer ...

  13. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Conference Publications and Posters National Trauma System Injury Prevention and Control Quality and Safety Conference Quality and ... Safety Resources About the Patient Education Program The Recovery Room Choosing Wisely Educational Programs Educational Programs Educational ...

  14. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Data Bank Trauma Quality Improvement Program Mentoring for Excellence in Trauma Surgery Advanced Trauma Life Support Verification, ... Patients Medical Professionals Skills Programs Find a Treatment Center Patient Safety Resources About the Patient Education Program ...

  15. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Shop ( 0 ) Cart Donate American College of Surgeons Education Patients and Family Skills Programs Ostomy Home Skills Program Ostomy Home Skills Program Adult Ostomy Pediatric Ostomy Programa de Destrezas para manejo ...

  16. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... ACS Careers at ACS About ACS Career Types Working at ACS ... Education Patients and Family Skills Programs Ostomy Home Skills Program Ostomy Home Skills Program Adult Ostomy ...

  17. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... of Education ACS Education and Training Courses Publications Education Program Videos Contact Us Clinical Congress Clinical Congress 2017 ... Treatment Center Patient Safety Resources About the Patient Education Program The Recovery Room Choosing Wisely Educational Programs Educational ...

  18. modeling and optimization of an electric power distribution network

    African Journals Online (AJOL)

    user

    distribution systems including distributed generation. A constructive heuristic algorithm (CHA) is proposed in [5] for the EDNEPP. In that work, the binary decision variables of the mixed binary integer non-linear problem. (MBINLP) are relaxed making the problem a nonlinear programming (NLP) problem. The NLP problem is ...

  19. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Program for Hospitals Trauma Systems Consultation Program Trauma Education Achieving Zero Preventable Deaths Conference Publications and Posters National Trauma System Injury ...

  20. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Life Support Verification, Review, and Consultation Program for Hospitals Trauma Systems Consultation Program Trauma Education Achieving Zero Preventable Deaths Conference Publications and Posters ...

  1. LANL Meteorology Program

    Energy Technology Data Exchange (ETDEWEB)

    Dewart, Jean Marie [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-02-09

    The goal of the Meteorology Program is to provide all routine meteorology measurements for LANL operational requirements. This report discusses the program, its routine operations, and other services.

  2. About the Clusters Program

    Science.gov (United States)

    The Environmental Technology Innovation Clusters Program advises cluster organizations, encourages collaboration between clusters, tracks U.S. environmental technology clusters, and connects EPA programs to cluster needs.

  3. [PIC Program Evaluation Forms.

    Science.gov (United States)

    Short, N. J.

    These 4 questionnaires are designed to elicit teacher and parent evaluations of the Prescriptive Instruction Center (PIC) program. Included are Teacher Evaluation of Program Effectiveness (14 items), M & M Evaluation of Program Implementation (methods and materials specialists; 11 items), Teacher Evaluation of Program Effectiveness--Case Study…

  4. Derivation of sorting programs

    Science.gov (United States)

    Varghese, Joseph; Loganantharaj, Rasiah

    1990-01-01

    Program synthesis for critical applications has become a viable alternative to program verification. Nested resolution and its extension are used to synthesize a set of sorting programs from their first order logic specifications. A set of sorting programs, such as, naive sort, merge sort, and insertion sort, were successfully synthesized starting from the same set of specifications.

  5. Stochastic Constraint Programming

    OpenAIRE

    Walsh, Toby

    2009-01-01

    To model combinatorial decision problems involving uncertainty and probability, we introduce stochastic constraint programming. Stochastic constraint programs contain both decision variables (which we can set) and stochastic variables (which follow a probability distribution). They combine together the best features of traditional constraint satisfaction, stochastic integer programming, and stochastic satisfiability. We give a semantics for stochastic constraint programs, and propose a number...

  6. Laser Programs Highlights 1998

    Energy Technology Data Exchange (ETDEWEB)

    Lowdermilk, H.; Cassady, C.

    1999-12-01

    This report covers the following topics: Commentary; Laser Programs; Inertial Confinement Fusion/National Ignition Facility (ICF/NIF); Atomic Vapor Laser Isotope Separation (AVLIS); Laser Science and Technology (LS&T); Information Science and Technology Program (IS&T); Strategic Materials Applications Program (SMAP); Medical Technology Program (MTP) and Awards.

  7. Program refinement in UNITY

    NARCIS (Netherlands)

    Vos, T.E.J.; Swierstra, S.D.

    2001-01-01

    Program refinement has received a lot of attention in the context of stepwise development of correct programs, since the introduction of transformational programming techniques by [Wir71, Hoa72, Ger75, BD77] in the seventies. This report presents a new framework of program refinement, that is

  8. Programs as Data Objects

    DEFF Research Database (Denmark)

    This book constitutes the refereed proceedings of the Second Symposium on Programs as Data Objects, PADO 2001, held in Aarhus, Denmark, in May 2001. The 14 revised full papers presented were carefully reviewed and selected from 30 submissions. Various aspects of looking at programs as data objects...... are covered from the point of view of program analysis, program transformation, computational complexity, etc....

  9. C++ Programming Language

    Science.gov (United States)

    Shaykhian, Gholam Ali

    2007-01-01

    C++ Programming Language: The C++ seminar covers the fundamentals of C++ programming language. The C++ fundamentals are grouped into three parts where each part includes both concept and programming examples aimed at for hands-on practice. The first part covers the functional aspect of C++ programming language with emphasis on function parameters and efficient memory utilization. The second part covers the essential framework of C++ programming language, the object-oriented aspects. Information necessary to evaluate various features of object-oriented programming; including encapsulation, polymorphism and inheritance will be discussed. The last part of the seminar covers template and generic programming. Examples include both user defined and standard templates.

  10. Generating Consistent Program Tutorials

    DEFF Research Database (Denmark)

    Vestdam, Thomas

    2002-01-01

    In this paper we present a tool that supports construction of program tutorials. A program tutorial provides the reader with an understanding of an example program by interleaving fragments of source code and explaining text. An example program can for example illustrate how to use a library...... or a framework. We present a means for specifying the fragments of a program that are to be in-lined in the tutorial text. These in-line fragments are defined by addressing named syntactical elements, such as classes and methods, but it is also possible to address individual code lines by labeling them...... with source markers. The tool helps ensuring consistency between program tutorial and example programs by extracting fragments of source code based on the fragment specifications and by detecting when a program tutorial is addressing program fragments that do not exist. The program tutorials are presented...

  11. Federal Wind Energy Program. Program summary. [USA

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-01-01

    The objective of the Federal Wind Energy Program is to accelerate the development of reliable and economically viable wind energy systems and enable the earliest possible commercialization of wind power. To achieve this objective for small and large wind systems requires advancing the technology, developing a sound industrial technology base, and addressing the non-technological issues which could deter the use of wind energy. This summary report outlines the projects being supported by the program through FY 1977 toward the achievement of these goals. It also outlines the program's general organization and specific program elements.

  12. Technology Commercialization Program 1991

    Energy Technology Data Exchange (ETDEWEB)

    1991-11-01

    This reference compilation describes the Technology Commercialization Program of the Department of Energy, Defense Programs. The compilation consists of two sections. Section 1, Plans and Procedures, describes the plans and procedures of the Defense Programs Technology Commercialization Program. The second section, Legislation and Policy, identifies legislation and policy related to the Program. The procedures for implementing statutory and regulatory requirements are evolving with time. This document will be periodically updated to reflect changes and new material.

  13. Multiobjective programming and planning

    CERN Document Server

    Cohon, Jared L

    2004-01-01

    This text takes a broad view of multiobjective programming, emphasizing the methods most useful for continuous problems. It reviews multiobjective programming methods in the context of public decision-making problems, developing each problem within a context that addresses practical aspects of planning issues. Topics include a review of linear programming, the formulation of the general multiobjective programming problem, classification of multiobjective programming methods, techniques for generating noninferior solutions, multiple-decision-making methods, multiobjective analysis of water reso

  14. Evaluasi Program English Club

    OpenAIRE

    Kurniawan, Mirdan; Herpratiwi, Herpratiwi; Purnomo, Eddy

    2015-01-01

    The purposes of this study were to 1) reveal students' perceptions about instructional English club program 2) reveal the students' perceptions about instructional English fun day program 3) reveal perception of students about instructional English wall magazine program. From the results of the study it was concluded that 1) students' perceptions of the instructional English club program was less advantages for students, 2) students' perceptions of instructional English fun day program have ...

  15. Inductive Temporal Logic Programming

    OpenAIRE

    Kolter, Robert

    2009-01-01

    We study the extension of techniques from Inductive Logic Programming (ILP) to temporal logic programming languages. Therefore we present two temporal logic programming languages and analyse the learnability of programs from these languages from finite sets of examples. In first order temporal logic the following topics are analysed: - How can we characterize the denotational semantics of programs? - Which proof techniques are best suited? - How complex is the learning task? In propositional ...

  16. Teaching Programming with Scratch

    OpenAIRE

    MIHALIČ, PETRA

    2014-01-01

    There are quite a few good programing languages and environments for teaching kids how to program. They help beginners learn basic programming constructs usually with help of interactive environment. In this thesis I will describe and compare a few of those languages and environments. Scratch is a language and programming environment that is also intended for learning programming using blocks that make writing complicated instructions easier and reduce beginners' difficulties with syntax erro...

  17. Programming Models in HPC

    Energy Technology Data Exchange (ETDEWEB)

    Shipman, Galen M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-06-13

    These are the slides for a presentation on programming models in HPC, at the Los Alamos National Laboratory's Parallel Computing Summer School. The following topics are covered: Flynn's Taxonomy of computer architectures; single instruction single data; single instruction multiple data; multiple instruction multiple data; address space organization; definition of Trinity (Intel Xeon-Phi is a MIMD architecture); single program multiple data; multiple program multiple data; ExMatEx workflow overview; definition of a programming model, programming languages, runtime systems; programming model and environments; MPI (Message Passing Interface); OpenMP; Kokkos (Performance Portable Thread-Parallel Programming Model); Kokkos abstractions, patterns, policies, and spaces; RAJA, a systematic approach to node-level portability and tuning; overview of the Legion Programming Model; mapping tasks and data to hardware resources; interoperability: supporting task-level models; Legion S3D execution and performance details; workflow, integration of external resources into the programming model.

  18. Analyzing Array Manipulating Programs by Program Transformation

    Science.gov (United States)

    Cornish, J. Robert M.; Gange, Graeme; Navas, Jorge A.; Schachte, Peter; Sondergaard, Harald; Stuckey, Peter J.

    2014-01-01

    We explore a transformational approach to the problem of verifying simple array-manipulating programs. Traditionally, verification of such programs requires intricate analysis machinery to reason with universally quantified statements about symbolic array segments, such as "every data item stored in the segment A[i] to A[j] is equal to the corresponding item stored in the segment B[i] to B[j]." We define a simple abstract machine which allows for set-valued variables and we show how to translate programs with array operations to array-free code for this machine. For the purpose of program analysis, the translated program remains faithful to the semantics of array manipulation. Based on our implementation in LLVM, we evaluate the approach with respect to its ability to extract useful invariants and the cost in terms of code size.

  19. Revealing the programming process

    DEFF Research Database (Denmark)

    Bennedsen, Jens; Caspersen, Michael Edelgaard

    2005-01-01

    One of the most important goals of an introductory programming course is that the students learn a systematic approach to the development of computer programs. Revealing the programming process is an important part of this; however, textbooks do not address the issue -- probably because...... the textbook medium is static and therefore ill-suited to expose the process of programming. We have found that process recordings in the form of captured narrated programming sessions are a simple, cheap, and efficient way of providing the revelation.We identify seven different elements of the programming...

  20. The CHROME Honors Program

    Science.gov (United States)

    Wilson, Eleanor

    2002-01-01

    The CHROME Honors Program was designed as a two-week residential program for 9th and 1Oth grade students participating in CHROME clubs. The curriculum focused on the health sciences with instruction from: (1) the science and health curriculum of the Dozoretz National Program for Minorities in Applied Sciences (DNIMAS) Program of Norfolk State University (NSU); (2) the humanities curriculum of the NSU Honors Program; (3) NASA-related curriculum in human physiology. An Advisory Committee was formed to work with the Project Coordinator in the design of the summer program.

  1. Parallel programming with PCN

    Energy Technology Data Exchange (ETDEWEB)

    Foster, I.; Tuecke, S.

    1991-09-01

    PCN is a system for developing and executing parallel programs. It comprises a high-level programming language, a set of tools for developing and debugging programs in this language, and interfaces to Fortran and C that allow the reuse of existing code in multilingual parallel programs. Programs developed using PCN are portable across many different workstations, networks, and parallel computers. This document provides all the information required to develop parallel programs with the PCN programming system. It includes both tutorial and reference material. It also presents the basic concepts that underlie PCN, particularly where these are likely to be unfamiliar to the reader, and provides pointers to other documentation on the PCN language, programming techniques, and tools. PCN is in the public domain. The latest version of both the software and this manual can be obtained by anonymous FTP from Argonne National Laboratory at info.mcs.anl.gov.

  2. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Stereotactic Breast Biopsy Accreditation Program Cancer Programs Staff Information Children's Surgery Children's Surgery Children's Surgery Children's Surgery Verification ACS NSQIP Pediatric Fees and Invoices Quality and ...

  3. Health Programs for Veterans

    Science.gov (United States)

    ... Health Administration » Health Programs for Veterans Veterans Health Administration Health Programs for Veterans Beyond the doctors and ... families of patients receiving medical care at major military and VA medical centers Geriatrics & Extended Care Geriatric ...

  4. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... entire surgical team with quality, comprehensive education. The standardized interactive program has been developed by the American ... Ostomy Home Skills Hospital Quality Improvement Package The standardized interactive program has been developed by the American ...

  5. LOADING SIMULATION PROGRAM C

    Data.gov (United States)

    U.S. Environmental Protection Agency — LSPC is the Loading Simulation Program in C++, a watershed modeling system that includes streamlined Hydrologic Simulation Program Fortran (HSPF) algorithms for...

  6. Social marketing program sales.

    Science.gov (United States)

    1987-01-01

    This table presents data on social marketing program sales for projects that provide more than 5000 couple-years of protection. Cited are social marketing programs in Bangladesh, Costa Rica, Egypt, El Salvador, Guatemala, Honduras, India, Indonesia, Jamaica, Nepal, Pakistan, Peru, and Sri Lanka. Included in the table are data on program funding, product sales (generally condoms, pills, and foaming tablets), and couple-years of protection provided. Among the social marketing programs reporting particularly high couple-years of protection levels are the Bangladesh Family Planning Social Marketing Program (1,165,100), the Egyptian Family Planning Association's Family for the Future Program (732,200), India's Nirodh Marketing Program (2,225,000), and Pakistan's Social Marketing Contraceptive Program (280,000).

  7. Daily bowel care program

    Science.gov (United States)

    ... gov/ency/patientinstructions/000133.htm Daily bowel care program To use the sharing features on this page, ... Work with your health care provider. Basic Bowel Program Keeping active helps prevent constipation. Try to walk, ...

  8. NCLOS program 2010 update.

    Science.gov (United States)

    2013-06-01

    The North Carolina Level of Service (NCLOS) program is a planning-level highway capacity analysis tool : developed for NCDOT under a previous project. The program uses the operational methodologies in the 2010 : Highway Capacity Manual (HCM), along w...

  9. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... ACS Insurance Programs ACS Discount Programs FACS Resources Career Connection Update Your Profile Member Communities Leadership Opportunities ... Group Icons in Surgery Archives Catalog Contact Us Careers at ACS Careers at ACS Careers at ACS ...

  10. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... and Safety Conference Upcoming Educational Opportunities MBSAQIP News Contact Us Breast Disease National Accreditation Program for Breast Centers National Accreditation Program for Breast Centers About NAPBC ...

  11. Advanced General Dentistry Program.

    Science.gov (United States)

    Barnes, Douglas M.; And Others

    1988-01-01

    A description of the University of Maryland at Baltimore's one-year postdoctoral program in advanced general dentistry focuses on its goals and objectives, curriculum design, patient population, faculty and staff, finances, and program evaluation measures. (MSE)

  12. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... System Strategic Partnership Military Health System Strategic Partnership Military Health System Strategic Partnership About Excelsior Surgical Society ... Quality Programs Overview About Quality Programs ACS Leadership in Quality ACS Leadership in Quality Setting the ...

  13. Intergenerational Programs in Schools.

    Science.gov (United States)

    Cohen-Mansfield, Jiska; Jensen, Barbara

    2017-03-01

    This study examined the prevalence, types, and perceived impact of intergenerational programs in schools. Programs involving senior volunteers assisting children, or children participating in activities with older people were considered. Of the schools reached, 47% reported intergenerational programming. Thirty-three schools in the Tel-Aviv region participated in the study. Data were collected from 85 seniors, 26 teachers, and 20 coordinators. Assessments included program characteristics, program preparation, and perceived benefits and difficulties. Both programs were reported to have beneficial effects for seniors and to benefit children in the academic, social, and emotional domains. However, programs appeared to attract different types of volunteers and different degrees of volunteer commitment. Findings suggest that there is a need to pay additional attention to both participants' specific requests and needs and to the allocation of resources to improve the design and implementation of intergenerational programs.

  14. Modeling EERE deployment programs

    Energy Technology Data Exchange (ETDEWEB)

    Cort, K. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hostick, D. J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Belzer, D. B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Livingston, O. V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2007-11-01

    The purpose of the project was to identify and characterize the modeling of deployment programs within the EERE Technology Development (TD) programs, address possible improvements to the modeling process, and note gaps in knowledge for future research.

  15. LOADING SIMULATION PROGRAM C

    Science.gov (United States)

    LSPC is the Loading Simulation Program in C++, a watershed modeling system that includes streamlined Hydrologic Simulation Program Fortran (HSPF) algorithms for simulating hydrology, sediment, and general water quality

  16. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Accreditation Program for Breast Centers About NAPBC Accreditation Education NAPBC Standards News Quality in Geriatric Surgery Coalition ... 4 and Recertification SSR Login MIPS Resources and Education Quality and Safety Conference Trauma Trauma Programs Trauma ...

  17. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... and Invoices Quality and Safety Conference Bariatric Surgery Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program ...

  18. Superfund Contract Laboratory Program

    Science.gov (United States)

    The Contract Laboratory Program (CLP) is a national network of EPA personnel, commercial laboratories, and support contractors whose primary mission is to provide data of known and documented quality to the Superfund program.

  19. Automated preventive maintenance program

    Science.gov (United States)

    Cea, E. J.; Grieger, T. H.

    1971-01-01

    Maintenance program which is concise and inexpensive to operate adapts to almost any system that has a FORTRAN compiler. Program operates on a stored data base with an output consisting of scheduling information and various management reports.

  20. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Education Cancer Education Cancer Programs Conference: Creating a Culture of Quality CoC Events Quality Education Quality Education ... OR EHR Incentive Program Global Codes and Data Collection New Medicare Card Project Medicare Enrollment and Participation ...

  1. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... About Trauma Programs BleedingControl.org Trauma Quality Programs Violence Prevention National Trauma Data Bank Trauma Quality Improvement ... Benefits Current Openings Newsroom Newsroom Newsroom Press Releases Media Resources The FIRST Trial ACS Publications ACS in ...

  2. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Associate Fellows Residents Medical Students Affiliate Members ACS Insurance Programs ACS Discount Programs FACS Resources Career Connection ... and Awards Overview Scholarships, Fellowships, and Awards Overview Health Policy Scholarships Scholarships for International Surgeons Research Scholarships ...

  3. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... and Canada) International Fellows Associate Fellows Residents Medical Students Affiliate Members ACS Insurance Programs ACS Discount Programs FACS Resources Career Connection Update Your Profile Member Communities Leadership Opportunities ...

  4. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Medical Professionals Skills Programs Find a Treatment Center Patient Safety Resources About the Patient Education Program The Recovery ... Trauma CME Nora Institute Nora Institute for Surgical Patient Safety Nora Institute for Surgical Patient Safety Advanced Skills ...

  5. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Be a YFA Leader Meetings and Events YFA Mentor Programs Top 10 Reasons to Participate Resources Webinars ... National Trauma Data Bank Trauma Quality Improvement Program Mentoring for Excellence in Trauma Surgery Advanced Trauma Life ...

  6. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... My OR EHR Incentive Program Global Codes and Data Collection New Medicare Card Project Medicare Enrollment and Participation ... self-care checklist Evaluation (Complete the Ostomy Patient Survey . We need your opinion!) Program outcomes The ACS ...

  7. ICASE Computer Science Program

    Science.gov (United States)

    1985-01-01

    The Institute for Computer Applications in Science and Engineering computer science program is discussed in outline form. Information is given on such topics as problem decomposition, algorithm development, programming languages, and parallel architectures.

  8. Entrez Programming Utilities

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Entrez Programming Utilities (E-utilities) are a set of eight server-side programs that provide a stable interface into the Entrez query and database system at...

  9. Veterans Choice Program

    Data.gov (United States)

    Department of Veterans Affairs — If you are already enrolled in VA health care, the Choice Program allows you to receive health care within your community. Using this program does NOT impact your...

  10. Crab Rationalization Permit Program

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Crab Rationalization Program (Program) allocates BSAI crab resources among harvesters, processors, and coastal communities. The North Pacific Fishery Management...

  11. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Member Fellows International Fellows Associate Fellows Residents Medical Students Affiliate Members Fees and Dues Realize the Potential ... and Canada) International Fellows Associate Fellows Residents Medical Students Affiliate Members ACS Insurance Programs ACS Discount Programs ...

  12. Coalbed Methane Outreach Program

    Science.gov (United States)

    Coalbed Methane Outreach Program, voluntary program seeking to reduce methane emissions from coal mining activities. CMOP promotes profitable recovery/use of coal mine methane (CMM), addressing barriers to using CMM instead of emitting it to atmosphere.

  13. HUD Program Income Limits

    Data.gov (United States)

    Department of Housing and Urban Development — Income limits used to determine the income eligibility of applicants for assistance under three programs authorized by the National Housing Act. These programs are...

  14. Astrophysics Program Overview; Briefing

    National Research Council Canada - National Science Library

    1998-01-01

    This is an overview briefing of the NAS Astrophysics programs. These program should lead the opening scientific frontiers and disseminate new knowledge, as the Hubble Space Telescope and Compton Gamma Ray Observatory are currently doing...

  15. Python to learn programming

    Science.gov (United States)

    Bogdanchikov, A.; Zhaparov, M.; Suliyev, R.

    2013-04-01

    Today we have a lot of programming languages that can realize our needs, but the most important question is how to teach programming to beginner students. In this paper we suggest using Python for this purpose, because it is a programming language that has neatly organized syntax and powerful tools to solve any task. Moreover it is very close to simple math thinking. Python is chosen as a primary programming language for freshmen in most of leading universities. Writing code in python is easy. In this paper we give some examples of program codes written in Java, C++ and Python language, and we make a comparison between them. Firstly, this paper proposes advantages of Python language in relation to C++ and JAVA. Then it shows the results of a comparison of short program codes written in three different languages, followed by a discussion on how students understand programming. Finally experimental results of students' success in programming courses are shown.

  16. Materials Sciences Programs

    Energy Technology Data Exchange (ETDEWEB)

    1977-01-01

    A compilation and index of the ERDA materials sciences program is presented. This compilation is intended for use by administrators, managers, and scientists to help coordinate research and as an aid in selecting new programs. (GHT)

  17. Parallel programming with PCN

    Energy Technology Data Exchange (ETDEWEB)

    Foster, I.; Tuecke, S.

    1991-12-01

    PCN is a system for developing and executing parallel programs. It comprises a high-level programming language, tools for developing and debugging programs in this language, and interfaces to Fortran and C that allow the reuse of existing code in multilingual parallel programs. Programs developed using PCN are portable across many different workstations, networks, and parallel computers. This document provides all the information required to develop parallel programs with the PCN programming system. In includes both tutorial and reference material. It also presents the basic concepts that underly PCN, particularly where these are likely to be unfamiliar to the reader, and provides pointers to other documentation on the PCN language, programming techniques, and tools. PCN is in the public domain. The latest version of both the software and this manual can be obtained by anonymous FTP from Argonne National Laboratory in the directory pub/pcn at info.mcs.anl.gov (c.f. Appendix A).

  18. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... for Excellence in Trauma Surgery Advanced Trauma Life Support Verification, Review, and Consultation Program for Hospitals Trauma Systems Consultation Program Trauma Education Achieving Zero Preventable Deaths ...

  19. Korea space program

    Science.gov (United States)

    Hong, Jai-Hak

    Though Korea's space activities are just in the infant stage, we are looking forward to joining the advanced countries in the space field. We have three on-going space programs: the KOREASAT Program, a sounding rocket program, and the KITSAT Program. And, we have three more programs that we are in the process of formulating: a small remote sensing satellite program, a data receiving station construction program, and the second generation KOREASAT program. We have several organizations which are involved with space-related activities: KARI, ETRI, SERI, and KAIST. KARI was founded in 1989 in accordance with the Aerospace Industry Development & Promotion Act for the purpose of conducting research on aicraft, satellites and scientific rockets, and supporting national aerospace development projects.

  20. NASA's Technology Utilization Program.

    Science.gov (United States)

    Farley, C. F.

    1972-01-01

    NASA's Technology Utilization Program is described, illustrating how it can be useful in achieving improved productivity, providing more jobs, solving public sector challenges, and strengthening the international competitive situation. Underlying the program is the fact that research and development conducted in NASA's aeronautics and space programs have generated much technical information concerning processes, products, or techniques which may be useful to engineers, doctors, or to others. The program is based on acquisition and publication, working with the user, and applications engineering.

  1. Reactive Programming in Java

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    Reactive Programming in gaining a lot of excitement. Many libraries, tools, and frameworks are beginning to make use of reactive libraries. Besides, applications dealing with big data or high frequency data can benefit from this programming paradigm. Come to this presentation to learn about what reactive programming is, what kind of problems it solves, how it solves them. We will take an example oriented approach to learning the programming model and the abstraction.

  2. Photovoltaic systems. Program summary

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-12-01

    Each of the Department of Energy's Photovoltaic Systems Program projects funded and/or in existence during fiscal year 1978 (October 1, 1977 through September 30, 1978) are described. The project sheets list the contractor, principal investigator, and contract number and funding and summarize the programs and status. The program is divided into various elements: program assessment and integration, research and advanced development, technology development, system definition and development, system application experiments, and standards and performance criteria. (WHK)

  3. Joint Program Management Handbook

    Science.gov (United States)

    1994-12-01

    by that Service. The Program/Product Manger, the Program / Project Management Office , and, in turn, the functional elements of each Participating...manning document for the Program/ Project Management Office which will incorporate the positions to be occupied by representatives of the Participating...Participating Service Senior Representative(s) within the Program/ Project Management Office will: (1) Speak for his parent Service in all matters

  4. Building Technologies Program Multi-Year Program Plan Program Portfolio Management 2008

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2008-01-01

    Building Technologies Program Multi-Year Program Plan 2008 for program portfolio management, including the program portfolio management process, program analysis, performance assessment, stakeholder interactions, and cross-cutting issues.

  5. Recommendation: Comprehensive Programming.

    Science.gov (United States)

    Kelly, Judith

    1989-01-01

    This article summarizes recommendations of the Richardson Study regarding a comprehensive approach to programing for gifted students. Basic components of comprehensive programing are outlined, and seven steps deemed essential to program development and implementation are described, as implemented by the Pyramid Project in four school districts in…

  6. Modern programming language

    Science.gov (United States)

    Feldman, G. H.; Johnson, J. A.

    1980-01-01

    Structural-programming language is especially-tailored for producing assembly language programs for MODCOMP II and IV mini-computes. Modern programming language consists of set of simple and powerful control structures that include sequencing alternative selection, looping, sub-module linking, comment insertion, statement continuation, and compilation termination capabilities.

  7. Pressure simulation program

    NARCIS (Netherlands)

    Knoll, B.; Phaff, J.C.; Gids, W.F. de

    1995-01-01

    A computer program has been developed to predict the wind pressure coefficients Cp on facades and roofs of block shaped buildings. The program is based on fits of measured data, including wind shielding by obstacles and terrain roughness. Main advantages of the program are: it needs no expertise of

  8. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Ostomy Home Skills Program Ostomy Home Skills Program Adult Ostomy Pediatric Ostomy Programa de Destrezas para manejo Doméstico de Ostomía Ostomy Home Skills Program Adult Ostomy Pediatric Ostomy Programa de Destrezas para manejo ...

  9. Programming the BBC micro

    CERN Document Server

    Ferguson, John D; Macari, Louie; Williams, Peter H

    1983-01-01

    Programming the BBC Micro is a 12-chapter book that begins with a description of the BBC microcomputer, its peripheral, and faults. Subsequent chapters focus on practice in programming, program development, graphics, words, numbers, sound, bits, bytes, and assembly language. The interfacing, file handling, and detailed description of BBC microcomputer are also shown.

  10. Linear Projective Program Syntax

    NARCIS (Netherlands)

    Bergstra, J.A.; Bethke, I.

    2004-01-01

    Based on an extremely simple program notation more advanced program features can be developed in linear projective program syntax such as conditional statements, while loops, recursion, use of an evaluation stack, object classes, method calls etc. Taking care of a cumulative and bottom up

  11. Surgical Technology Program Guide.

    Science.gov (United States)

    Georgia Univ., Athens. Dept. of Vocational Education.

    This surgical technology program guide presents the standard curriculum for technical institutes in Georgia. The curriculum addresses the minimum competencies for a surgical technology program. The program guide is designed to relate primarily to the development of those skills needed by individuals in the field to provide services in the…

  12. Volunteer Mother Program.

    Science.gov (United States)

    Castellucci, Arthur, Ed.

    Five members of a school library administration class developed guidelines for a Volunteer Mother Program in public school libraries. Guidelines were stated for the following aspects of volunteer programs: (1) reasons for using volunteers; (2) introduction to the program; (3) recruitment; (4) qualifications; (5) amount of help needed; (6)…

  13. Engineering honours program

    NARCIS (Netherlands)

    Ir Antoine waal; Ir. Peter van Kollenburg

    2011-01-01

    In September 2009 the department of Engineering of Fontys University of Applied Sciences in the Netherlands has started a pilot honours program for excellent engineering students called PRogram OUstanding Development (PROUD). Aim of this program is to give those engineering students, who have the

  14. Special Milk Program

    Science.gov (United States)

    US Department of Agriculture, 2009

    2009-01-01

    The Special Milk Program provides milk to children in schools, child care institutions and eligible camps that do not participate in other Federal child nutrition meal service programs. The program reimburses schools and institutions for the milk they serve. In 2008, 4,676 schools and residential child care institutions participated, along with…

  15. Programming Languages RESONAN

    Indian Academy of Sciences (India)

    In this article we will briefly review various programming lan- ... notation should also match the type of algorithm. For example, programming languages to solve science and engineering problems should support arithmetic using wide ranging, high .... programs using a library of reusable 'components' was imperative.

  16. Customer Service Programming

    Science.gov (United States)

    1982-01-01

    Use of computer program STRCMACS has enabled Illinois Bell Telephone, a subsidiary of American Telephone and Telegraph to cut software development costs about 10 percent by reducing program maintenance and by allowing the department to bring other software into operation more quickly. It has also been useful in company training of programming staff.

  17. Weatherization and Intergovernmental Program - Weatherization Assistance Program

    Energy Technology Data Exchange (ETDEWEB)

    None

    2010-06-01

    The U.S. Department of Energy’s (DOE) Weatherization Assistance Program reduces energy costs for low-income households by increasing the energy efficiency of their homes, while ensuring their health and safety.

  18. Clean Coal Technology Programs: Program Update 2009

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-10-01

    The purpose of the Clean Coal Technology Programs: Program Update 2009 is to provide an updated status of the U.S. Department of Energy (DOE) commercial-scale demonstrations of clean coal technologies (CCT). These demonstrations have been performed under the Clean Coal Technology Demonstration Program (CCTDP), the Power Plant Improvement Initiative (PPII), and the Clean Coal Power Initiative (CCPI). Program Update 2009 provides: (1) a discussion of the role of clean coal technology demonstrations in improving the nation’s energy security and reliability, while protecting the environment using the nation’s most abundant energy resource—coal; (2) a summary of the funding and costs of the demonstrations; and (3) an overview of the technologies being demonstrated, along with fact sheets for projects that are active, recently completed, or recently discontinued.

  19. Scallop License Limitation Program (SLLP) Permit Program

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A federal Scallop License Limitation Program (SLLP) license is required onboard any vessel deployed in scallop fisheries in Federal waters off Alaska (except for...

  20. Fuels from biomass program. Program summary

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-01-01

    An overview of the ongoing research, development, and demonstration efforts of the period Oct. 1, 1976--Sept. 30, 1977 is presented. Accomplishments are highlighted and plans for continued activities are included. Discussion is presented under the following section headings: the Fuels from Biomass Program; organizational and functional responsibilities; program funding; fiscal year 1977 summary tables; current projects: production and collection of biomass and conversion of biomass; bibliography; index of contractors; and, appendix--unsolicited proposal requirements. (JGB)

  1. Beginning programming for dummies

    CERN Document Server

    Wang, Wallace

    2011-01-01

    Do you think the programmers who work at your office are magical wizards who hold special powers that manipulate your computer? Believe it or not, anyone can learn how to write programs, and it doesn't take a higher math and science education to start. Beginning Programming for Dummies shows you how computer programming works without all the technical details or hard programming language. It explores the common parts of every computer programming language and how to write for multiple platforms like Windows, Mac OS X, or Linux. This easily accessible guide provides you with the tools

  2. C++ how to program

    CERN Document Server

    Deitel, Paul J

    2014-01-01

    This best-selling comprehensive text is aimed at readers with little or no programming experience. It teaches programming by presenting the concepts in the context of full working programs and takes an early-objects approach. The authors emphasize achieving program clarity through structured and object-oriented programming, software reuse and component-oriented software construction. The Ninth Edition encourages students to connect computers to the community, using the Internet to solve problems and make a difference in our world. All content has been carefully fine-tuned in response to a team of distinguished academic and industry reviewers.

  3. Programming in COBOL

    CERN Document Server

    Lancaster, G T

    2014-01-01

    Programming in COBOL is a simple yet concise how-to book that teaches the programming language in a short yet effective step-by-step manner, which can be easily understood by anyone with sufficient knowledge in information technology. Covering first the advantages of COBOL over other programming languages, the book discusses COBOL's divisions - identification, environment, procedure, and data, and then describes the testing of the COBOL source programs and program questions. The book is valuable for those who wish to learn basic COBOL language, but do not have the time to take manufacturers' o

  4. Program enhancements demonstrated

    Energy Technology Data Exchange (ETDEWEB)

    1980-08-11

    Enhancements to the Gastran Program for simulation of steady-state gathering systems are outlined. The operation of the modifications, as well as 2 new major engineering programs (Pipetran and Matbal), is discussed as an example of useable software programs to assist oil and gas production. Pipetran is a program that utilizes the best available multiphase flow correlations in a network structure for design and analysis of multiphase flow gathering systems. Matbal is a general purpose oil material balance program for obtaining reservoir performance information at a reasonable cost for all reservoirs with pressure below the bubble point.

  5. Mini Project Programming Exams

    DEFF Research Database (Denmark)

    Nørmark, Kurt; Thomsen, Lone Leth; Torp, Kristian

    2008-01-01

    A number of different types of final programming exams used or considered at the Department of Computer Science, Aalborg University, are identified and analyzed. Based on this analysis, a new type of programming exam is introduced called a Mini Project Programming (MIP) exam. MIP is a group......-based programming assignment that is intended as a medium-scale programming effort followed by a final oral exam. MIP is characterized and compared to existing types of final programming exams by use of a number of independent criteria. The paper motivates the MIP approach and reports on our experience over four...... years. The MIP exam is a compromise between (1) a long problem-based project exam and (2) a short oral or written programming exam. It is concluded that the strengths of MIP are the high degree of realism in the exam assignment and comprehensiveness relative to the course syllabus. The main challenge...

  6. Functional Programming in R

    DEFF Research Database (Denmark)

    Mailund, Thomas

    2017-01-01

    Master functions and discover how to write functional programs in R. In this book, you'll make your functions pure by avoiding side-effects; you’ll write functions that manipulate other functions, and you’ll construct complex functions using simpler functions as building blocks. In Functional...... Programming in R, you’ll see how we can replace loops, which can have side-effects, with recursive functions that can more easily avoid them. In addition, the book covers why you shouldn't use recursion when loops are more efficient and how you can get the best of both worlds. Functional programming...... is a style of programming, like object-oriented programming, but one that focuses on data transformations and calculations rather than objects and state. Where in object-oriented programming you model your programs by describing which states an object can be in and how methods will reveal or modify...

  7. Functional Programming in R

    DEFF Research Database (Denmark)

    Mailund, Thomas

    Master functions and discover how to write functional programs in R. In this book, you'll make your functions pure by avoiding side-effects; you’ll write functions that manipulate other functions, and you’ll construct complex functions using simpler functions as building blocks. In Functional...... Programming in R, you’ll see how we can replace loops, which can have side-effects, with recursive functions that can more easily avoid them. In addition, the book covers why you shouldn't use recursion when loops are more efficient and how you can get the best of both worlds. Functional programming...... is a style of programming, like object-oriented programming, but one that focuses on data transformations and calculations rather than objects and state. Where in object-oriented programming you model your programs by describing which states an object can be in and how methods will reveal or modify...

  8. Functional Programming in R

    DEFF Research Database (Denmark)

    Mailund, Thomas

    is a style of programming, like object-oriented programming, but one that focuses on data transformations and calculations rather than objects and state. Where in object-oriented programming you model your programs by describing which states an object can be in and how methods will reveal or modify......Master functions and discover how to write functional programs in R. In this book, you'll make your functions pure by avoiding side-effects; you’ll write functions that manipulate other functions, and you’ll construct complex functions using simpler functions as building blocks. In Functional...... Programming in R, you’ll see how we can replace loops, which can have side-effects, with recursive functions that can more easily avoid them. In addition, the book covers why you shouldn't use recursion when loops are more efficient and how you can get the best of both worlds. Functional programming...

  9. Utility Green Pricing Programs: A Statistical Analysis of Program Effectiveness

    Energy Technology Data Exchange (ETDEWEB)

    Wiser, R.; Olson, S.; Bird, L.; Swezey, B.

    2004-02-01

    This report analyzes actual utility green pricing program data to provide further insight into which program features might help maximize both customer participation in green pricing programs and the amount of renewable energy purchased by customers in those programs.

  10. Aspect-Oriented Programming

    Science.gov (United States)

    Elrad, Tzilla (Editor); Filman, Robert E. (Editor); Bader, Atef (Editor)

    2001-01-01

    Computer science has experienced an evolution in programming languages and systems from the crude assembly and machine codes of the earliest computers through concepts such as formula translation, procedural programming, structured programming, functional programming, logic programming, and programming with abstract data types. Each of these steps in programming technology has advanced our ability to achieve clear separation of concerns at the source code level. Currently, the dominant programming paradigm is object-oriented programming - the idea that one builds a software system by decomposing a problem into objects and then writing the code of those objects. Such objects abstract together behavior and data into a single conceptual and physical entity. Object-orientation is reflected in the entire spectrum of current software development methodologies and tools - we have OO methodologies, analysis and design tools, and OO programming languages. Writing complex applications such as graphical user interfaces, operating systems, and distributed applications while maintaining comprehensible source code has been made possible with OOP. Success at developing simpler systems leads to aspirations for greater complexity. Object orientation is a clever idea, but has certain limitations. We are now seeing that many requirements do not decompose neatly into behavior centered on a single locus. Object technology has difficulty localizing concerns invoking global constraints and pandemic behaviors, appropriately segregating concerns, and applying domain-specific knowledge. Post-object programming (POP) mechanisms that look to increase the expressiveness of the OO paradigm are a fertile arena for current research. Examples of POP technologies include domain-specific languages, generative programming, generic programming, constraint languages, reflection and metaprogramming, feature-oriented development, views/viewpoints, and asynchronous message brokering. (Czarneclu and

  11. Report on ONR Conference on ’Dolphin Behavior and Cognition: Comparative and Ecological Aspects’, Hubbs-Sea World Research Institute, San Diego, California, 92109, July 6-9, 1983.

    Science.gov (United States)

    1983-11-01

    Brookfield Zoo Brookfield, IL 60513 Robert Buhr Animal communication and cognition; Department of Linguistics neurolinguistics and neuropsychology Brown...Rockefeller University 1230 York Avenue New York, NY 10021 Henry Halff (observer) Personnel and Training Research Program .,,; Code 442 PT Arlington, VA 22212...observer) Physiology and Neurobiology Research Program Code 441 NP e., Office of Naval Research Arlington, VA 22217 Bernd Wursig Cetacean behavior

  12. Programming Scala Scalability = Functional Programming + Objects

    CERN Document Server

    Wampler, Dean

    2009-01-01

    Learn how to be more productive with Scala, a new multi-paradigm language for the Java Virtual Machine (JVM) that integrates features of both object-oriented and functional programming. With this book, you'll discover why Scala is ideal for highly scalable, component-based applications that support concurrency and distribution. Programming Scala clearly explains the advantages of Scala as a JVM language. You'll learn how to leverage the wealth of Java class libraries to meet the practical needs of enterprise and Internet projects more easily. Packed with code examples, this book provides us

  13. Programming in biomolecular computation

    DEFF Research Database (Denmark)

    Hartmann, Lars Røeboe; Jones, Neil; Simonsen, Jakob Grue

    2011-01-01

    Our goal is to provide a top-down approach to biomolecular computation. In spite of widespread discussion about connections between biology and computation, one question seems notable by its absence: Where are the programs? We identify a number of common features in programming that seem...... conspicuously absent from the literature on biomolecular computing; to partially redress this absence, we introduce a model of computation that is evidently programmable, by programs reminiscent of low-level computer machine code; and at the same time biologically plausible: its functioning is defined...... by a single and relatively small set of chemical-like reaction rules. Further properties: the model is stored-program: programs are the same as data, so programs are not only executable, but are also compilable and interpretable. It is universal: all computable functions can be computed (in natural ways...

  14. Programming in biomolecular computation

    DEFF Research Database (Denmark)

    Hartmann, Lars Røeboe; Jones, Neil; Simonsen, Jakob Grue

    2010-01-01

    Our goal is to provide a top-down approach to biomolecular computation. In spite of widespread discussion about connections between biology and computation, one question seems notable by its absence: Where are the programs? We introduce a model of computation that is evidently programmable......, by programs reminiscent of low-level computer machine code; and at the same time biologically plausible: its functioning is defined by a single and relatively small set of chemical-like reaction rules. Further properties: the model is stored-program: programs are the same as data, so programs are not only...... in a strong sense: a universal algorithm exists, that is able to execute any program, and is not asymptotically inefficient. A prototype model has been implemented (for now in silico on a conventional computer). This work opens new perspectives on just how computation may be specified at the biological level....

  15. MIDI Programming in Scheme

    DEFF Research Database (Denmark)

    Nørmark, Kurt

    2010-01-01

    makes it possible to carry out systematic modifications and transformations of MIDI contents with use of pure functional programming. Side by side with the XML-inspired MIDI language, the paper describes an Emacs-based, textual programming environment that supports the MIDI programming process....... The programming environment also supports a variety of interactive features - similar to MIDI sequencers - but restricted to a textual representation of the music. The main contributions of the work are considered to be (1) An accumulated MIDI function library, which can transform MIDI files in many non......-trivial ways; (2) A proposed working process alternating between creative mode and programmatic editing mode within a MIDI programming environment; and (3) A textual MIDI programming environment with embedded support of many interactive, MIDI-related functionalities....

  16. Functional Programming in R

    DEFF Research Database (Denmark)

    Mailund, Thomas

    that state, in functional programming you model programs by describing how functions translate input data to output data. Functions themselves are considered to be data you can manipulate and much of the strength of functional programming comes from manipulating functions; that is, building more complex......Master functions and discover how to write functional programs in R. In this book, you'll make your functions pure by avoiding side-effects; you’ll write functions that manipulate other functions, and you’ll construct complex functions using simpler functions as building blocks. In Functional...... Programming in R, you’ll see how we can replace loops, which can have side-effects, with recursive functions that can more easily avoid them. In addition, the book covers why you shouldn't use recursion when loops are more efficient and how you can get the best of both worlds. Functional programming...

  17. A nursing bioethics program.

    Science.gov (United States)

    Albrizio, M A; Ozuna, J; Mattheis, R; Saunders, J

    1992-01-01

    In 1985 the Seattle Veterans' Administration Medical Center nursing service implemented a nursing program for bioethics with three goals: (1) to expand the nurse's knowledge of bioethical principles, (2) to develop the nurse's ability and confidence in analyzing bioethical dilemmas, and (3) to increase bioethical application at the bedside. Two psychosocial clinical nurse specialists (CNSs) led this highly successful nursing program that prepared nurses to more actively and responsibly participate in bioethical decision making within the medical center. The program offers an annual workshop for new members, holds a monthly discussion group, conducts a yearly enrichment program, and completes an annual evaluation report. This article describes nursing service bioethics program from planning through evaluation and the role of the CNS as program coordinator, facilitator, and educator in the expanding field of bioethics.

  18. Test-driven programming

    Science.gov (United States)

    Georgiev, Bozhidar; Georgieva, Adriana

    2013-12-01

    In this paper, are presented some possibilities concerning the implementation of a test-driven development as a programming method. Here is offered a different point of view for creation of advanced programming techniques (build tests before programming source with all necessary software tools and modules respectively). Therefore, this nontraditional approach for easier programmer's work through building tests at first is preferable way of software development. This approach allows comparatively simple programming (applied with different object-oriented programming languages as for example JAVA, XML, PYTHON etc.). It is predictable way to develop software tools and to provide help about creating better software that is also easier to maintain. Test-driven programming is able to replace more complicated casual paradigms, used by many programmers.

  19. Meteorological Monitoring Program

    Energy Technology Data Exchange (ETDEWEB)

    Hancock, H.A. Jr. [ed.; Parker, M.J.; Addis, R.P.

    1994-09-01

    The purpose of this technical report is to provide a comprehensive, detailed overview of the meteorological monitoring program at the Savannah River Site (SRS) near Aiken, South Carolina. The principle function of the program is to provide current, accurate meteorological data as input for calculating the transport and diffusion of any unplanned release of an atmospheric pollutant. The report is recommended for meteorologists, technicians, or any personnel who require an in-depth understanding of the meteorological monitoring program.

  20. Programming Language Pragmatics

    CERN Document Server

    Scott, Michael L

    2009-01-01

    Programming Language Pragmatics is the most comprehensive programming language textbook available today. Taking the perspective that language design and language implementation are tightly interconnected, and that neither can be fully understood in isolation, this critically acclaimed and bestselling book has been thoroughly updated to cover the most recent developments in programming language design. With a new chapter on run-time program management and expanded coverage of concurrency, this new edition provides both students and professionals alike with a solid understanding of the most impo