WorldWideScience

Sample records for network tissues thomas

  1. Instructional Applications of Virginia's Public Education Network (VA PEN): Thomas Jefferson On-Line.

    Science.gov (United States)

    Willett-Smith, Stephanie

    The motivational value of Virginia's Public Education Network (VA PEN), specifically the Thomas Jefferson On-line discussion group, is examined in this study. The instructional value of the network with respect to student motivation in fourth grade students of varied ability was gauged through observation of actual hands-on network experience,…

  2. Thomas Aquinas

    DEFF Research Database (Denmark)

    Haaning, Aksel

    2011-01-01

    Artiklen præsenterer Thomas Aquinas i højmiddelalderens intellektuelle historie, reviderer den for tiden gældende historiegrafi og præsenterer Aquinas' erotiske mystik fra prologen til Sentenskommentaren (ca.1252) og diskuterer "Aurora consurgens" som et muligt sidste skrift af den berømte...

  3. NCI’s Cooperative Human Tissue Network

    Science.gov (United States)

    Quality biospecimens are a foundational resource for cancer research. One of NCI’s longest running biospecimen programs is the Cooperative Human Tissue Network, a resource mainly for basic discovery and early translational research.

  4. The reconstruction and analysis of tissue specific human metabolic networks.

    Science.gov (United States)

    Hao, Tong; Ma, Hong-Wu; Zhao, Xue-Ming; Goryanin, Igor

    2012-02-01

    Human tissues have distinct biological functions. Many proteins/enzymes are known to be expressed only in specific tissues and therefore the metabolic networks in various tissues are different. Though high quality global human metabolic networks and metabolic networks for certain tissues such as liver have already been studied, a systematic study of tissue specific metabolic networks for all main tissues is still missing. In this work, we reconstruct the tissue specific metabolic networks for 15 main tissues in human based on the previously reconstructed Edinburgh Human Metabolic Network (EHMN). The tissue information is firstly obtained for enzymes from Human Protein Reference Database (HPRD) and UniprotKB databases and transfers to reactions through the enzyme-reaction relationships in EHMN. As our knowledge of tissue distribution of proteins is still very limited, we replenish the tissue information of the metabolic network based on network connectivity analysis and thorough examination of the literature. Finally, about 80% of proteins and reactions in EHMN are determined to be in at least one of the 15 tissues. To validate the quality of the tissue specific network, the brain specific metabolic network is taken as an example for functional module analysis and the results reveal that the function of the brain metabolic network is closely related with its function as the centre of the human nervous system. The tissue specific human metabolic networks are available at .

  5. Vascularization and Angiogenesis in Tissue Engineering: Beyond Creating Static Networks

    NARCIS (Netherlands)

    Rouwkema, Jeroen; Khademhosseini, A.

    2016-01-01

    Engineered tissues need a vascular network to supply cells with nutrients and oxygen after implantation. A network that can connect to the vasculature of the patient after implantation can be included during in vitro culture. For optimal integration, this network needs to be highly organized,

  6. "Thomas Becket" Haapsalus

    Index Scriptorium Estoniae

    2002-01-01

    Haapslu Jaani kirikus esietendus 28. juunil EELK Haapsalu Püha Johannese koguduse ja teatri Randlane ühisprojektina "Thomas Becket" J. Anouilh' draama "Becket ehk Jumala au" järgi, lavastaja R. Tammet

  7. Exploring regulation in tissues with eQTL networks.

    Science.gov (United States)

    Fagny, Maud; Paulson, Joseph N; Kuijjer, Marieke L; Sonawane, Abhijeet R; Chen, Cho-Yi; Lopes-Ramos, Camila M; Glass, Kimberly; Quackenbush, John; Platig, John

    2017-09-12

    Characterizing the collective regulatory impact of genetic variants on complex phenotypes is a major challenge in developing a genotype to phenotype map. Using expression quantitative trait locus (eQTL) analyses, we constructed bipartite networks in which edges represent significant associations between genetic variants and gene expression levels and found that the network structure informs regulatory function. We show, in 13 tissues, that these eQTL networks are organized into dense, highly modular communities grouping genes often involved in coherent biological processes. We find communities representing shared processes across tissues, as well as communities associated with tissue-specific processes that coalesce around variants in tissue-specific active chromatin regions. Node centrality is also highly informative, with the global and community hubs differing in regulatory potential and likelihood of being disease associated.

  8. Thomas Jefferson's Academical Village

    DEFF Research Database (Denmark)

    Foote, Jonathan; Frohburg, Jan

    2017-01-01

    This is an essay written for the Festschrift of Karl-Heinz Schmitz, Professor at Bauhaus-Universität Weimar. It reflects on some aspects of Thomas Jefferson's design for the University of Virginia in relation to Professor's Schmitz' teachings and interests.......This is an essay written for the Festschrift of Karl-Heinz Schmitz, Professor at Bauhaus-Universität Weimar. It reflects on some aspects of Thomas Jefferson's design for the University of Virginia in relation to Professor's Schmitz' teachings and interests....

  9. Dynamics of HIV infection in lymphoid tissue network.

    Science.gov (United States)

    Nakaoka, Shinji; Iwami, Shingo; Sato, Kei

    2016-03-01

    Human immunodeficiency virus (HIV) is a fast replicating ribonucleic acid virus, which can easily mutate in order to escape the effects of drug administration. Hence, understanding the basic mechanisms underlying HIV persistence in the body is essential in the development of new therapies that could eradicate HIV infection. Lymphoid tissues are the primary sites of HIV infection. Despite the recent progress in real-time monitoring technology, HIV infection dynamics in a whole body is unknown. Mathematical modeling and simulations provide speculations on global behavior of HIV infection in the lymphatic system. We propose a new mathematical model that describes the spread of HIV infection throughout the lymphoid tissue network. In order to represent the volume difference between lymphoid tissues, we propose the proportionality of several kinetic parameters to the lymphoid tissues' volume distribution. Under this assumption, we perform extensive numerical computations in order to simulate the spread of HIV infection in the lymphoid tissue network. Numerical computations simulate single drug treatments of an HIV infection. One of the important biological speculations derived from this study is a drug saturation effect generated by lymphoid network connection. This implies that a portion of reservoir lymphoid tissues to which drug is not sufficiently delivered would inhibit HIV eradication despite of extensive drug injection.

  10. Hydrogel Bioprinted Microchannel Networks for Vascularization of Tissue Engineering Constructs

    Science.gov (United States)

    Bertassoni, Luiz E.; Cecconi, Martina; Manoharan, Vijayan; Nikkhah, Mehdi; Hjortnaes, Jesper; Cristino, Ana Luiza; Barabaschi, Giada; Demarchi, Danilo; Dokmeci, Mehmet R.; Yang, Yunzhi; Khademhosseini, Ali

    2014-01-01

    Vascularization remains a critical challenge in tissue engineering. The development of vascular networks within densely populated and metabolically functional tissues facilitate transport of nutrients and removal of waste products, thus preserving cellular viability over a long period of time. Despite tremendous progress in fabricating complex tissue constructs in the past few years, approaches for controlled vascularization within hydrogel based engineered tissue constructs have remained limited. Here, we report a three dimensional (3D) micromolding technique utilizing bioprinted agarose template fibers to fabricate microchannel networks with various architectural features within photo cross linkable hydrogel constructs. Using the proposed approach, we were able to successfully embed functional and perfusable microchannels inside methacrylated gelatin (GelMA), star poly (ethylene glycol-co-lactide) acrylate (SPELA), poly (ethylene glycol) dimethacrylate (PEGDMA) and poly (ethylene glycol) diacrylate (PEGDA) hydrogels at different concentrations. In particular, GelMA hydrogels were used as a model to demonstrate the functionality of the fabricated vascular networks in improving mass transport, cellular viability and differentiation within the cell-laden tissue constructs. In addition, successful formation of endothelial monolayers within the fabricated channels was confirmed. Overall, our proposed strategy represents an effective technique for vascularization of hydrogel constructs with useful applications in tissue engineering and organs on a chip. PMID:24860845

  11. The importance of establishing an international network of tissue banks and regional tissue processing centers.

    Science.gov (United States)

    Morales Pedraza, Jorge

    2014-03-01

    During the past four decades, many tissue banks have been established across the world with the aim of supplying sterilized tissues for clinical use and research purposes. Between 1972 and 2005, the International Atomic Energy Agency supported the establishment of more than sixty of these tissue banks in Latin America and the Caribbean, Asia and the Pacific, Africa and Eastern Europe; promoted the use of the ionizing radiation technique for the sterilization of the processed tissues; and encouraged cooperation between the established tissue banks during the implementation of its program on radiation and tissue banking at national, regional and international levels. Taking into account that several of the established tissue banks have gained a rich experience in the procurement, processing, sterilization, storage, and medical use of sterilized tissues, it is time now to strengthen further international and regional cooperation among interested tissue banks located in different countries. The purpose of this cooperation is to share the experience gained by these banks in the procurement, processing, sterilization, storage, and used of different types of tissues in certain medical treatments and research activities. This could be done through the establishment of a network of tissue banks and a limited number of regional tissue processing centers in different regions of the world.

  12. Morgan, Prof. Thomas Hunt

    Indian Academy of Sciences (India)

    Morgan, Prof. Thomas Hunt Nobel Laureate (Medicine) - 1933. Date of birth: 25 September 1866. Date of death: 4 December 1945. YouTube ... Posted on 21 December 2017. ASTROPHYSICS: An Observational View of the Universe. Math Art and Design: MAD about Math, Math Education and Outreach. Math and Finance ...

  13. Thomas Jefferson's Computer.

    Science.gov (United States)

    Smith, Catherine F.

    1996-01-01

    Notes that taken together, Thomas Jefferson's contributions to the history of writing technology demonstrate a virtual "computer." Links Jefferson's development of writing technology to his democratic political philosophy. Argues that this link should interest writing teachers. Suggests that Jeffersonian optimism effectively counters…

  14. Happy Birthday, Thomas Edison!

    Science.gov (United States)

    Dalton, Edward A.

    1997-01-01

    Discusses the work and inventions of Thomas Edison and their use in making teachers and students aware of the importance of electrotechnology in their lives and in their futures. Enables students to learn about science, experimentation, research, the process of invention, and the thrill of discovery. Describes educational resources available from…

  15. Thomas Mann som bibelfortolker

    DEFF Research Database (Denmark)

    Nielsen, Kirsten

    2007-01-01

    Artiklen beskæftiger sig med Thomas Manns reception og transformation af den gammeltestamentlige fortælling om Josef og hans brødre. Særlig interesse samler sig om de gudsbilleder, værket indeholder, herunder relationen til Satan. Det karakteristiske ved Manns gudsbillede er, at Gud ikke er tydelig...

  16. Practicing like Thomas Edison.

    Science.gov (United States)

    Baum, Neil; Ornstein, Hal

    2013-01-01

    For many centuries, medicine has practiced in a vacuum, and the healthcare profession has been isolated from other scientific disciplines. Beginning in the 20th century, doctors and scientists have looked to others for ideas, suggestions, innovations, and new technologies. Probably no one in the past hundred years has done so much to change the world than Thomas Edison. This article will discuss eight principles of Edison and how they may apply to our profession and our practices.

  17. Biofabricated soft network composites for cartilage tissue engineering.

    Science.gov (United States)

    Bas, Onur; De-Juan-Pardo, Elena M; Meinert, Christoph; D'Angella, Davide; Baldwin, Jeremy G; Bray, Laura J; Wellard, R Mark; Kollmannsberger, Stefan; Rank, Ernst; Werner, Carsten; Klein, Travis J; Catelas, Isabelle; Hutmacher, Dietmar W

    2017-05-12

    Articular cartilage from a material science point of view is a soft network composite that plays a critical role in load-bearing joints during dynamic loading. Its composite structure, consisting of a collagen fiber network and a hydrated proteoglycan matrix, gives rise to the complex mechanical properties of the tissue including viscoelasticity and stress relaxation. Melt electrospinning writing allows the design and fabrication of medical grade polycaprolactone (mPCL) fibrous networks for the reinforcement of soft hydrogel matrices for cartilage tissue engineering. However, these fiber-reinforced constructs underperformed under dynamic and prolonged loading conditions, suggesting that more targeted design approaches and material selection are required to fully exploit the potential of fibers as reinforcing agents for cartilage tissue engineering. In the present study, we emulated the proteoglycan matrix of articular cartilage by using highly negatively charged star-shaped poly(ethylene glycol)/heparin hydrogel (sPEG/Hep) as the soft matrix. These soft hydrogels combined with mPCL melt electrospun fibrous networks exhibited mechanical anisotropy, nonlinearity, viscoelasticity and morphology analogous to those of their native counterpart, and provided a suitable microenvironment for in vitro human chondrocyte culture and neocartilage formation. In addition, a numerical model using the p-version of the finite element method (p-FEM) was developed in order to gain further insights into the deformation mechanisms of the constructs in silico, as well as to predict compressive moduli. To our knowledge, this is the first study presenting cartilage tissue-engineered constructs that capture the overall transient, equilibrium and dynamic biomechanical properties of human articular cartilage.

  18. Classifications of multispectral colorectal cancer tissues using convolution neural network

    Directory of Open Access Journals (Sweden)

    Hawraa Haj-Hassan

    2017-01-01

    Full Text Available Background: Colorectal cancer (CRC is the third most common cancer among men and women. Its diagnosis in early stages, typically done through the analysis of colon biopsy images, can greatly improve the chances of a successful treatment. This paper proposes to use convolution neural networks (CNNs to predict three tissue types related to the progression of CRC: benign hyperplasia (BH, intraepithelial neoplasia (IN, and carcinoma (Ca. Methods: Multispectral biopsy images of thirty CRC patients were retrospectively analyzed. Images of tissue samples were divided into three groups, based on their type (10 BH, 10 IN, and 10 Ca. An active contour model was used to segment image regions containing pathological tissues. Tissue samples were classified using a CNN containing convolution, max-pooling, and fully-connected layers. Available tissue samples were split into a training set, for learning the CNN parameters, and test set, for evaluating its performance. Results: An accuracy of 99.17% was obtained from segmented image regions, outperforming existing approaches based on traditional feature extraction, and classification techniques. Conclusions: Experimental results demonstrate the effectiveness of CNN for the classification of CRC tissue types, in particular when using presegmented regions of interest.

  19. Deep convolutional neural network approach for forehead tissue thickness estimation

    Directory of Open Access Journals (Sweden)

    Manit Jirapong

    2017-09-01

    Full Text Available In this paper, we presented a deep convolutional neural network (CNN approach for forehead tissue thickness estimation. We use down sampled NIR laser backscattering images acquired from a novel marker-less near-infrared laser-based head tracking system, combined with the beam’s incident angle parameter. These two-channel augmented images were constructed for the CNN input, while a single node output layer represents the estimated value of the forehead tissue thickness. The models were – separately for each subject – trained and tested on datasets acquired from 30 subjects (high resolution MRI data is used as ground truth. To speed up training, we used a pre-trained network from the first subject to bootstrap training for each of the other subjects. We could show a clear improvement for the tissue thickness estimation (mean RMSE of 0.096 mm. This proposed CNN model outperformed previous support vector regression (mean RMSE of 0.155 mm or Gaussian processes learning approaches (mean RMSE of 0.114 mm and eliminated their restrictions for future research.

  20. Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease.

    Science.gov (United States)

    Talukdar, Husain A; Foroughi Asl, Hassan; Jain, Rajeev K; Ermel, Raili; Ruusalepp, Arno; Franzén, Oscar; Kidd, Brian A; Readhead, Ben; Giannarelli, Chiara; Kovacic, Jason C; Ivert, Torbjörn; Dudley, Joel T; Civelek, Mete; Lusis, Aldons J; Schadt, Eric E; Skogsberg, Josefin; Michoel, Tom; Björkegren, Johan L M

    2016-03-23

    Inferring molecular networks can reveal how genetic perturbations interact with environmental factors to cause common complex diseases. We analyzed genetic and gene expression data from seven tissues relevant to coronary artery disease (CAD) and identified regulatory gene networks (RGNs) and their key drivers. By integrating data from genome-wide association studies, we identified 30 CAD-causal RGNs interconnected in vascular and metabolic tissues, and we validated them with corresponding data from the Hybrid Mouse Diversity Panel. As proof of concept, by targeting the key drivers AIP, DRAP1, POLR2I, and PQBP1 in a cross-species-validated, arterial-wall RGN involving RNA-processing genes, we re-identified this RGN in THP-1 foam cells and independent data from CAD macrophages and carotid lesions. This characterization of the molecular landscape in CAD will help better define the regulation of CAD candidate genes identified by genome-wide association studies and is a first step toward achieving the goals of precision medicine. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  1. Thomas Kibble visits CERN

    CERN Multimedia

    Rosaria Marraffino

    2014-01-01

    Emeritus Professor Sir Thomas W.B. Kibble, from Imperial College London visited LHC for the first time last week and delivered a colloquium on the genesis of electroweak unification and the Brout-Englert-Higgs mechanism.   From left to right: Jim Virdee, Tiziano Camporesi, Tom Kibble and Austin Ball on the visit to CMS. On his way back from Trieste, where he received the Abdus Salam International Centre for Theoretical Physics' Dirac Medal, Tom Kibble stopped by CERN for his first visit to the LHC. Kibble had a standing invitation from Jim Virdee, former CMS spokesperson, who is also a researcher from Imperial College London. Peter Jenni (left) and Tom Kibble tour the ATLAS detector. (Image: Erwan Bertrand) Kibble made the trip to CERN a family outing and brought along 14 relatives,  including his children and grandchildren. He visited the ATLAS detector with Peter Jenni, its former spokesperson, on Friday 10 October. In the afternoon, Kibble delivered a colloquium in the...

  2. [Thomas Fincke and trigonometry].

    Science.gov (United States)

    Schönbeck, Jürgen

    2004-01-01

    Thomas Fincke (January 6th, 1561 - April 24th, 1650), born in Flensburg (Germany), was one of the very most important and significant scientists in Denmark during the seventeenth century, a mathematician and astrologer and physician in the beginning of modern science, a representative of humanism and an influentual academic organizer. He studied in Strasbourg (since 1577) and Padua (since 1583) and received his M.D. in Basel (1587), he practised as a physician throughtout his life (since 1587 or 1590) and became a professor at Copenhagen (1591). But he was best known because of his Geometriae rotundi libri XIIII (1583), a famous book on plane and spherical trigonometry, based not on Euclid but on Petrus Ramus. In this influentual work, in which Fincke introduced the terms tangent and secant and probable first noticed the Law of Tangents and the so-called Newton-Oppel-Mauduit-Simpson-Mollweide-Gauss-formula, he showed himself to be ,,abreast of the mathematics of his time".

  3. Liquid Crystalline Networks toward Regenerative Medicine and Tissue Repair.

    Science.gov (United States)

    Martella, Daniele; Paoli, Paolo; Pioner, Josè M; Sacconi, Leonardo; Coppini, Raffaele; Santini, Lorenzo; Lulli, Matteo; Cerbai, Elisabetta; Wiersma, Diederik S; Poggesi, Corrado; Ferrantini, Cecilia; Parmeggiani, Camilla

    2017-12-01

    The communication reports the use of liquid crystalline networks (LCNs) for engineering tissue cultures with human cells. Their ability as cell scaffolds for different cell lines is demonstrated. Preliminary assessments of the material biocompatibility are performed on human dermal fibroblasts and murine muscle cells (C2C12), demonstrating that coatings or other treatments are not needed to use the acrylate-based materials as support. Moreover, it is found that adherent C2C12 cells undergo differentiation, forming multinucleated myotubes, which show the typical elongated shape, and contain bundles of stress fibers. Once biocompatibility is demonstrated, the same LCN films are used as a substrate for culturing human induced pluripotent stem cell-derived cardiomyocites (hiPSC-CMs) proving that LCNs are capable to develop adult-like dimensions and a more mature cell function in a short period of culture in respect to standard supports. The demonstrated biocompatibility together with the extraordinary features of LCNs opens to preparation of complex cell scaffolds, both patterned and stimulated, for dynamic cell culturing. The ability of these materials to improve cell maturation and differentiation will be developed toward engineered heart and skeletal muscular tissues exploring regenerative medicine toward bioartificial muscles for injured sites replacement. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Thomas Jefferson and American Biology

    Science.gov (United States)

    Coonen, Lester P.; Porter, Charlotte M.

    1976-01-01

    Presented are the numerous contributions made by Thomas Jefferson to the fields of biological sciences. In addition to his actual contributions and discoveries, his extensive verbal and literacy support of the sciences is traced. (SL)

  5. Disease gene prioritization by integrating tissue-specific molecular networks using a robust multi-network model.

    Science.gov (United States)

    Ni, Jingchao; Koyuturk, Mehmet; Tong, Hanghang; Haines, Jonathan; Xu, Rong; Zhang, Xiang

    2016-11-10

    Accurately prioritizing candidate disease genes is an important and challenging problem. Various network-based methods have been developed to predict potential disease genes by utilizing the disease similarity network and molecular networks such as protein interaction or gene co-expression networks. Although successful, a common limitation of the existing methods is that they assume all diseases share the same molecular network and a single generic molecular network is used to predict candidate genes for all diseases. However, different diseases tend to manifest in different tissues, and the molecular networks in different tissues are usually different. An ideal method should be able to incorporate tissue-specific molecular networks for different diseases. In this paper, we develop a robust and flexible method to integrate tissue-specific molecular networks for disease gene prioritization. Our method allows each disease to have its own tissue-specific network(s). We formulate the problem of candidate gene prioritization as an optimization problem based on network propagation. When there are multiple tissue-specific networks available for a disease, our method can automatically infer the relative importance of each tissue-specific network. Thus it is robust to the noisy and incomplete network data. To solve the optimization problem, we develop fast algorithms which have linear time complexities in the number of nodes in the molecular networks. We also provide rigorous theoretical foundations for our algorithms in terms of their optimality and convergence properties. Extensive experimental results show that our method can significantly improve the accuracy of candidate gene prioritization compared with the state-of-the-art methods. In our experiments, we compare our methods with 7 popular network-based disease gene prioritization algorithms on diseases from Online Mendelian Inheritance in Man (OMIM) database. The experimental results demonstrate that our methods

  6. Principles of Biomimetic Vascular Network Design Applied to a Tissue-Engineered Liver Scaffold

    Science.gov (United States)

    Hoganson, David M.; Pryor, Howard I.; Spool, Ira D.; Burns, Owen H.; Gilmore, J. Randall

    2010-01-01

    Branched vascular networks are a central component of scaffold architecture for solid organ tissue engineering. In this work, seven biomimetic principles were established as the major guiding technical design considerations of a branched vascular network for a tissue-engineered scaffold. These biomimetic design principles were applied to a branched radial architecture to develop a liver-specific vascular network. Iterative design changes and computational fluid dynamic analysis were used to optimize the network before mold manufacturing. The vascular network mold was created using a new mold technique that achieves a 1:1 aspect ratio for all channels. In vitro blood flow testing confirmed the physiologic hemodynamics of the network as predicted by computational fluid dynamic analysis. These results indicate that this biomimetic liver vascular network design will provide a foundation for developing complex vascular networks for solid organ tissue engineering that achieve physiologic blood flow. PMID:20001254

  7. Thomas, Prof. Sir John Meurig

    Indian Academy of Sciences (India)

    Thomas, Prof. Sir John Meurig FRS. Date of birth: 15 December 1932. Address: Department of Materials Science and, Metallurgy, New Museums Site, 27, Babbage Road, Cambridge CB3 0FS, U.K.. Contact: Office: (+44-1223) 33 4300. Fax: (+44-1223) 33 4567. Email: jmt2@cam.ac.uk. YouTube; Twitter; Facebook; Blog ...

  8. The Vision of Thomas Jefferson.

    Science.gov (United States)

    Jones, Robert F.

    1993-01-01

    Contends that it was the blend of public service and public interests that distinguish the life of Thomas Jefferson. Discusses Jefferson's political philosophy found in his writings. Explains that nearly all of his writing was done to accomplish specific goals, although it had significance far beyond the immediate context. (CFR)

  9. Thomas Jefferson and the Constitution.

    Science.gov (United States)

    Peterson, Merrill D.

    1987-01-01

    Examines Thomas Jefferson's role in the making and interpretation of the United States Constitution. Discusses the dominant features of Jefferson's constitutional theory; the character of Jefferson's presidency; and Jefferson's ongoing concern about constitutional preservation and change. Lists important dates in the history of the constitution.…

  10. Thomas Moran: "The Grand Canyon."

    Science.gov (United States)

    Brubaker, Ann

    1986-01-01

    Presents a lesson plan for introducing students in grades four through six to Thomas Moran's painting, "The Grand Canyon." The goal of the lesson is to illustrate the importance of the American West as a subject for artists in the nineteenth century. (JDH)

  11. Confronting Thomas Jefferson, Slave Owner.

    Science.gov (United States)

    Blackman, James A.

    1992-01-01

    Although Thomas Jefferson's view of freedom was the cornerstone of the Declaration of Independence, this founding father owned 170 slaves to run his 5,000 acre plantation. This article describes a unit developed by the Monticello (Virginia) Education Department that teaches secondary students about slave Isaac Jefferson while exposing them to…

  12. Engineering reaction-diffusion networks with properties of neural tissue.

    Science.gov (United States)

    Litschel, Thomas; Norton, Michael M; Tserunyan, Vardges; Fraden, Seth

    2018-01-03

    We present an experimental system of networks of coupled non-linear chemical reactors, which we theoretically model within a reaction-diffusion framework. The networks consist of patterned arrays of diffusively coupled nanoliter-scale reactors containing the Belousov-Zhabotinsky (BZ) reaction. Microfluidic fabrication techniques are developed that provide the ability to vary the network topology and the reactor coupling strength and offer the freedom to choose whether an arbitrary reactor is inhibitory or excitatory coupled to its neighbor. This versatile experimental and theoretical framework can be used to create a wide variety of chemical networks. Here we design, construct and characterize chemical networks that achieve the complexity of central pattern generators (CPGs), which are found in the autonomic nervous system of a variety of organisms.

  13. Prediction of tissue-specific cis-regulatory modules using Bayesian networks and regression trees

    Directory of Open Access Journals (Sweden)

    Chen Xiaoyu

    2007-12-01

    Full Text Available Abstract Background In vertebrates, a large part of gene transcriptional regulation is operated by cis-regulatory modules. These modules are believed to be regulating much of the tissue-specificity of gene expression. Results We develop a Bayesian network approach for identifying cis-regulatory modules likely to regulate tissue-specific expression. The network integrates predicted transcription factor binding site information, transcription factor expression data, and target gene expression data. At its core is a regression tree modeling the effect of combinations of transcription factors bound to a module. A new unsupervised EM-like algorithm is developed to learn the parameters of the network, including the regression tree structure. Conclusion Our approach is shown to accurately identify known human liver and erythroid-specific modules. When applied to the prediction of tissue-specific modules in 10 different tissues, the network predicts a number of important transcription factor combinations whose concerted binding is associated to specific expression.

  14. Cellular neural network modelling of soft tissue dynamics for surgical simulation.

    Science.gov (United States)

    Zhang, Jinao; Zhong, Yongmin; Smith, Julian; Gu, Chengfan

    2017-07-20

    Currently, the mechanical dynamics of soft tissue deformation is achieved by numerical time integrations such as the explicit or implicit integration; however, the explicit integration is stable only under a small time step, whereas the implicit integration is computationally expensive in spite of the accommodation of a large time step. This paper presents a cellular neural network method for stable simulation of soft tissue deformation dynamics. The non-rigid motion equation is formulated as a cellular neural network with local connectivity of cells, and thus the dynamics of soft tissue deformation is transformed into the neural dynamics of the cellular neural network. Results show that the proposed method can achieve good accuracy at a small time step. It still remains stable at a large time step, while maintaining the computational efficiency of the explicit integration. The proposed method can achieve stable soft tissue deformation with efficiency of explicit integration for surgical simulation.

  15. New tools for non-invasive exploration of collagen network in cartilaginous tissue-engineered substitute.

    Science.gov (United States)

    Henrionnet, Christel; Dumas, Dominique; Hupont, Sébastien; Stoltz, Jean François; Mainard, Didier; Gillet, Pierre; Pinzano, Astrid

    2017-01-01

    In tissue engineering approaches, the quality of substitutes is a key element to determine its ability to treat cartilage defects. However, in clinical practice, the evaluation of tissue-engineered cartilage substitute quality is not possible due to the invasiveness of the standard procedure, which is to date histology. The aim of this work was to validate a new innovative system performed from two-photon excitation laser adapted to an optical macroscope to evaluate at macroscopic scale the collagen network in cartilage tissue-engineered substitutes in confrontation with gold standard histologic techniques or immunohistochemistry to visualize type II collagen. This system permitted to differentiate the quality of collagen network between ITS and TGF-β1 treatments. Multiscale large field imaging combined to multimodality approaches (SHG-TCSPC) at macroscopical scale represent an innovative and non-invasive technique to monitor the quality of collagen network in cartilage tissue-engineered substitutes before in vivo implantation.

  16. Deep tissue near-infrared imaging for vascular network analysis

    Directory of Open Access Journals (Sweden)

    Kübra Seker

    2017-05-01

    Full Text Available Subcutaneous vein network plays important roles to maintain microcirculation that is related to some diagnostic aspects. Despite developments of optical imaging technologies, still the difficulties about deep skin vascular imaging have been continued. On the other hand, since hemoglobin concentration of human blood has key role in the veins imaging by optical manner, the used wavelength in vascular imaging, must be chosen considering absorption of hemoglobin. In this research, we constructed a near infrared (NIR light source because of lower absorption of hemoglobin in this optical region. To obtain vascular image, reflectance geometry was used. Next, from recorded images, vascular network analysis, such as calculation of width of vascular of interest and complexity of selected region were implemented. By comparing with other modalities, we observed that proposed imaging system has great advantages including nonionized radiation, moderate penetration depth of 0.5–3mm and diameter of 1mm, cost-effective and algorithmic simplicity for analysis.

  17. THOMAS AQUINAS'TA MUTLULUK

    Directory of Open Access Journals (Sweden)

    Muammer İSKENDEROĞLU

    2005-06-01

    Full Text Available Thomas Aquinas is one of the greatest thinkers of Christianity. His ethical theory, togetherwith the theories of Augustine and Abelard, constitutes one of the main ethical theories ofMedieval Christianity. Aquinas develops his theory most extensively and systematically inthe Second Part of the Summa Theologica. For Aquinas ethics has two principal topics: first,what is the ultimate goal of human being, and second, how that goal is to be achieved. Theaim of this study is to present Aquinas' understanding of happiness in general. For thisreason it will discuss the following questions: What is the ultimate goal of human being?What constitutes man's happiness? What is happiness? What are the things required forhappiness? Whether happiness can be attained? The article concludes that Aquinas tries toharmonise Aristotelian ethics with Christianity, and in doing so he adds new dimensions tothe Aristotelian ethics.

  18. Thomas Bartholin. Domus Anatomica Hafniensis brevissima descripta

    DEFF Research Database (Denmark)

    Bruun, Niels W.; Fink-Jensen, Morten

    In 1662 Thomas Bartholin published A Short Description of the Anatomy House in Copenhagen, which describes the layout of the Anatomy House alongside the first eighteen years of its history.......In 1662 Thomas Bartholin published A Short Description of the Anatomy House in Copenhagen, which describes the layout of the Anatomy House alongside the first eighteen years of its history....

  19. Imaging regenerating bone tissue based on neural networks applied to micro-diffraction measurements

    Energy Technology Data Exchange (ETDEWEB)

    Campi, G.; Pezzotti, G. [Institute of Crystallography, CNR, via Salaria Km 29.300, I-00015, Monterotondo Roma (Italy); Fratini, M. [Centro Fermi -Museo Storico della Fisica e Centro Studi e Ricerche ' Enrico Fermi' , Roma (Italy); Ricci, A. [Deutsches Elektronen-Synchrotron DESY, Notkestraße 85, D-22607 Hamburg (Germany); Burghammer, M. [European Synchrotron Radiation Facility, B. P. 220, F-38043 Grenoble Cedex (France); Cancedda, R.; Mastrogiacomo, M. [Istituto Nazionale per la Ricerca sul Cancro, and Dipartimento di Medicina Sperimentale dell' Università di Genova and AUO San Martino Istituto Nazionale per la Ricerca sul Cancro, Largo R. Benzi 10, 16132, Genova (Italy); Bukreeva, I.; Cedola, A. [Institute for Chemical and Physical Process, CNR, c/o Physics Dep. at Sapienza University, P-le A. Moro 5, 00185, Roma (Italy)

    2013-12-16

    We monitored bone regeneration in a tissue engineering approach. To visualize and understand the structural evolution, the samples have been measured by X-ray micro-diffraction. We find that bone tissue regeneration proceeds through a multi-step mechanism, each step providing a specific diffraction signal. The large amount of data have been classified according to their structure and associated to the process they came from combining Neural Networks algorithms with least square pattern analysis. In this way, we obtain spatial maps of the different components of the tissues visualizing the complex kinetic at the base of the bone regeneration.

  20. Development of a transplantation transmission sentinel network to improve safety and traceability of organ and tissues.

    Science.gov (United States)

    Strong, D Michael; Seem, Debbie; Taylor, Gloria; Parker, Jory; Stewart, Darren; Kuehnert, Matthew J

    2010-11-01

    The US lags behind other developed countries in creating a system to monitor disease transmission and other complications from human allograft use, despite a pressing need. The risks of transmission are amplified in transplantation, since at least 8 organs and more than 100 tissues can be recovered from a single common organ and tissue donor. Moreover, since many allografts collected in the US are distributed internationally, tissue safety is a global concern. In June 2005, participants of a US government-sponsored workshop concluded that a communication network for the tracking and reporting of disease transmissions for tissues and organs was critically needed. The United Network for Organ Sharing (UNOS) entered into a cooperative agreement with the Centers for Disease Control and Prevention (CDC) in 2006 to develop a system prototype. Over the following 3 years, the Transplantation Transmission Sentinel Network (TTSN) was developed and piloted with the participation of organ procurement organizations, tissue banks and transplant centers. The prototype centered around three elements of data entry: (1) donation, (2) tissue implantation, and (3) adverse event. The pilot proved that a system can be built and operated successfully, but also suggested that users may be hesitant to report adverse events. CDC has requested further input on scope and cost to build a transplant surveillance infrastructure for a fully functional national system. For tissues however, in contrast to organs, tracking from recovery to implantation will be necessary before a system is operable, requiring common identifiers and nomenclature. Until a US sentinel network is operational, future transmission events that are preventable may result nationally and globally due to its absence.

  1. Towards Implantable Body Sensor Networks - Performance of MICS Band Radio Communication in Animal Tissue

    NARCIS (Netherlands)

    Karuppiah Ramachandran, Vignesh Raja; Meratnia, Nirvana; Zhang, Kui; Havinga, Paul J.M.

    Reliable wireless communication inside the human body is crucial for the design of implantable body sensor networks (IBSN). The tissues in human body are heterogeneous and have dierent conductivity and permitivity, which make the modeling of the wireless channel challenging. The design of upper

  2. Network-Based Method for Identifying Co- Regeneration Genes in Bone, Dentin, Nerve and Vessel Tissues.

    Science.gov (United States)

    Chen, Lei; Pan, Hongying; Zhang, Yu-Hang; Feng, Kaiyan; Kong, XiangYin; Huang, Tao; Cai, Yu-Dong

    2017-10-02

    Bone and dental diseases are serious public health problems. Most current clinical treatments for these diseases can produce side effects. Regeneration is a promising therapy for bone and dental diseases, yielding natural tissue recovery with few side effects. Because soft tissues inside the bone and dentin are densely populated with nerves and vessels, the study of bone and dentin regeneration should also consider the co-regeneration of nerves and vessels. In this study, a network-based method to identify co-regeneration genes for bone, dentin, nerve and vessel was constructed based on an extensive network of protein-protein interactions. Three procedures were applied in the network-based method. The first procedure, searching, sought the shortest paths connecting regeneration genes of one tissue type with regeneration genes of other tissues, thereby extracting possible co-regeneration genes. The second procedure, testing, employed a permutation test to evaluate whether possible genes were false discoveries; these genes were excluded by the testing procedure. The last procedure, screening, employed two rules, the betweenness ratio rule and interaction score rule, to select the most essential genes. A total of seventeen genes were inferred by the method, which were deemed to contribute to co-regeneration of at least two tissues. All these seventeen genes were extensively discussed to validate the utility of the method.

  3. Three-dimensional Organization of Layered Apical Cytoskeletal Networks Associated with Mouse Airway Tissue Development

    Science.gov (United States)

    Tateishi, Kazuhiro; Nishida, Tomoki; Inoue, Kanako; Tsukita, Sachiko

    2017-03-01

    The cytoskeleton is an essential cellular component that enables various sophisticated functions of epithelial cells by forming specialized subcellular compartments. However, the functional and structural roles of cytoskeletons in subcellular compartmentalization are still not fully understood. Here we identified a novel network structure consisting of actin filaments, intermediate filaments, and microtubules directly beneath the apical membrane in mouse airway multiciliated cells and in cultured epithelial cells. Three-dimensional imaging by ultra-high voltage electron microscopy and immunofluorescence revealed that the morphological features of each network depended on the cell type and were spatiotemporally integrated in association with tissue development. Detailed analyses using Odf2 mutant mice, which lack ciliary basal feet and apical microtubules, suggested a novel contribution of the intermediate filaments to coordinated ciliary beating. These findings provide a new perspective for viewing epithelial cell differentiation and tissue morphogenesis through the structure and function of apical cytoskeletal networks.

  4. Evaluation of Raman spectra of human brain tumor tissue using the learning vector quantization neural network

    Science.gov (United States)

    Liu, Tuo; Chen, Changshui; Shi, Xingzhe; Liu, Chengyong

    2016-05-01

    The Raman spectra of tissue of 20 brain tumor patients was recorded using a confocal microlaser Raman spectroscope with 785 nm excitation in vitro. A total of 133 spectra were investigated. Spectra peaks from normal white matter tissue and tumor tissue were analyzed. Algorithms, such as principal component analysis, linear discriminant analysis, and the support vector machine, are commonly used to analyze spectral data. However, in this study, we employed the learning vector quantization (LVQ) neural network, which is typically used for pattern recognition. By applying the proposed method, a normal diagnosis accuracy of 85.7% and a glioma diagnosis accuracy of 89.5% were achieved. The LVQ neural network is a recent approach to excavating Raman spectra information. Moreover, it is fast and convenient, does not require the spectra peak counterpart, and achieves a relatively high accuracy. It can be used in brain tumor prognostics and in helping to optimize the cutting margins of gliomas.

  5. Fermi-Walker transport and Thomas precession

    Science.gov (United States)

    Pastor Lambare, Justo

    2017-07-01

    An exact derivation of the Thomas precession formula is presented based on the Fermi-Walker transport equation. Given that the Thomas precession effect is not a particularly intuitive phenomenon, such that when discovered in 1925 it took by surprise even experts in relativity theory, Einstein included, an alternative perspective can be useful at an intermediate level for physics students. The existing literature linking the Thomas precession to Fermi-Walker transport use geometric algebra as mathematical tool. Here the mathematics is kept within the limits of the usual vector and tensor algebra commonly used in special relativity theory at a level appropriate for advanced undergraduate and beginning graduate students.

  6. Thomas Jefferson National Accelerator Facility

    Energy Technology Data Exchange (ETDEWEB)

    Grames, Joseph; Higinbotham, Douglas; Montgomery, Hugh

    2010-09-08

    The Thomas Jefferson National Accelerator Facility (Jefferson Lab) in Newport News, Virginia, USA, is one of ten national laboratories under the aegis of the Office of Science of the U.S. Department of Energy (DOE). It is managed and operated by Jefferson Science Associates, LLC. The primary facility at Jefferson Lab is the Continuous Electron Beam Accelerator Facility (CEBAF) as shown in an aerial photograph in Figure 1. Jefferson Lab was created in 1984 as CEBAF and started operations for physics in 1995. The accelerator uses superconducting radio-frequency (srf) techniques to generate high-quality beams of electrons with high-intensity, well-controlled polarization. The technology has enabled ancillary facilities to be created. The CEBAF facility is used by an international user community of more than 1200 physicists for a program of exploration and study of nuclear, hadronic matter, the strong interaction and quantum chromodynamics. Additionally, the exceptional quality of the beams facilitates studies of the fundamental symmetries of nature, which complement those of atomic physics on the one hand and of high-energy particle physics on the other. The facility is in the midst of a project to double the energy of the facility and to enhance and expand its experimental facilities. Studies are also pursued with a Free-Electron Laser produced by an energy-recovering linear accelerator.

  7. Multi-tissue omics analyses reveal molecular regulatory networks for puberty in composite beef cattle.

    Directory of Open Access Journals (Sweden)

    Angela Cánovas

    Full Text Available Puberty is a complex physiological event by which animals mature into an adult capable of sexual reproduction. In order to enhance our understanding of the genes and regulatory pathways and networks involved in puberty, we characterized the transcriptome of five reproductive tissues (i.e. hypothalamus, pituitary gland, ovary, uterus, and endometrium as well as tissues known to be relevant to growth and metabolism needed to achieve puberty (i.e., longissimus dorsi muscle, adipose, and liver. These tissues were collected from pre- and post-pubertal Brangus heifers (3/8 Brahman; Bos indicus x 5/8 Angus; Bos taurus derived from a population of cattle used to identify quantitative trait loci associated with fertility traits (i.e., age of first observed corpus luteum (ACL, first service conception (FSC, and heifer pregnancy (HPG. In order to exploit the power of complementary omics analyses, pre- and post-puberty co-expression gene networks were constructed by combining the results from genome-wide association studies (GWAS, RNA-Seq, and bovine transcription factors. Eight tissues among pre-pubertal and post-pubertal Brangus heifers revealed 1,515 differentially expressed and 943 tissue-specific genes within the 17,832 genes confirmed by RNA-Seq analysis. The hypothalamus experienced the most notable up-regulation of genes via puberty (i.e., 204 out of 275 genes. Combining the results of GWAS and RNA-Seq, we identified 25 loci containing a single nucleotide polymorphism (SNP associated with ACL, FSC, and (or HPG. Seventeen of these SNP were within a gene and 13 of the genes were expressed in uterus or endometrium. Multi-tissue omics analyses revealed 2,450 co-expressed genes relative to puberty. The pre-pubertal network had 372,861 connections whereas the post-pubertal network had 328,357 connections. A sub-network from this process revealed key transcriptional regulators (i.e., PITX2, FOXA1, DACH2, PROP1, SIX6, etc.. Results from these multi-tissue

  8. Tissue factor activates allosteric networks in factor VIIa through structural and dynamic changes

    DEFF Research Database (Denmark)

    Madsen, Jesper Jonasson; Persson, E.; Olsen, O. H.

    2015-01-01

    Background: Tissue factor (TF) promotes colocalization of enzyme (factorVIIa) and substrate (FX or FIX), and stabilizes the active conformation of FVIIa. Details on how TF induces structural and dynamic changes in the catalytic domain of FVIIa to enhance its efficiency remain elusive. Objective......: To elucidate the activation of allosteric networks in the catalytic domain of the FVIIa protease it is when bound to TF.MethodsLong-timescale molecular dynamics simulations of FVIIa, free and in complex with TF, were executed and analyzed by dynamic network analysis. Results: Allosteric paths of correlated...

  9. Thomas Jefferson and the Purposes of Education.

    Science.gov (United States)

    Jewett, Thomas O.

    1997-01-01

    Thomas Jefferson was the first conspicuous U.S. advocate of free education supported by local taxation and of state aid to higher education. He believed that only an educated citizenry could assume the responsibilities of self-government. (SK)

  10. Thomas Hart Benton's Home and Studio.

    Science.gov (United States)

    Herberholz, Barbara

    2000-01-01

    Focuses on Thomas Hart Benton, describing his house and studio in Kansas City, Missouri. Considers issues such as his life as the child of a congressman, his formal and informal art education, and his artwork. (CMK)

  11. Caribbean ST Thomas trap Logbook Survey (Vessels)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains catch (landed catch) and effort for fishing trips made by vessels fishing in St. Thomas. The catch and effort data for the entire trip are...

  12. Professionaalne marketing - edu pant / Thomas Westerberg

    Index Scriptorium Estoniae

    Westerberg, Thomas

    1999-01-01

    Majanduslanguse perioodil tuleb fokusseerida oma plaanid tulevikku, sel perioodil avalduvad turundusjuhtide tõelised ja varjatud professionaalsed oskused. Thomas Westerbergi, Coca-Cola Baltic Beverages Ltd. tegevdirektori ettekanne Majanduskonverentsil "Kuidas olla edukas majanduslanguse perioodil"

  13. Thomas Reid's Fundamental Rules of Eloquence.

    Science.gov (United States)

    Skopec, Eric W.

    1978-01-01

    Examines Thomas Reid's philosophy of rhetoric and identifies the principles to which he was committed, including his classification of knowledge, emphasis on artistic expression, and theory of natural signification. (JMF)

  14. [Thomas Addison and the adrenal gland].

    Science.gov (United States)

    Smans, Lisanne C C J; Zelissen, Pierre M J

    2012-01-01

    The famous and beautifully illustrated monograph "On the Constitutional and Local Effects of Disease of the Suprarenal Capsules" was published by Thomas Addison in 1855. This was the first description of the disease that now bears his name. Thomas Addison provided the first real contribution to the knowledge of adrenal function after three centuries of non-productive speculation and is one of the founders of modern endocrinology.

  15. A transportation network for human ovarian tissue is indispensable to success for fertility preservation.

    Science.gov (United States)

    Kyono, K; Hashimoto, T; Toya, M; Koizumi, M; Sasaki, C; Shibasaki, S; Aono, N; Nakamura, Y; Obata, R; Okuyama, N; Ogura, Y; Igarashi, H

    2017-09-02

    The purpose of this study was to examine the efficacy of an ovarian tissue transportation network for fertility preservation (FP) for cancer patients in Japan. PubMed was searched for papers on transportation of human ovarian tissue for FP. We analyzed population, area, number of cancer patients for ovarian tissue cryopreservation (OTC), quality control/assessment and safety, cost of a cryopreservation center for the building for 30 years, and medical fees of cancer patients (operation, cryopreservation, and storage of ovarian tissue). More than twenty babies have been born in Denmark and Germany through a transportation system. Up to 400 new patients a year need OTC. The fees for removal, cryopreservation, and storage for 5 years, and transplantation of ovarian tissue are around €5,000, €4,000, and €5,000, respectively. It costs more than €5 million to establish and maintain one cryopreservation center for 30 years. If we have a few cryopreservation centers in Japan, we can cryopreserve 400 patients' ovarian tissue per year by safer slow freezing and maintain quality control/assessment. We need to lighten the patients' burden for easy to use FP by a government subsidy and medical insurance coverage. This model has been termed the Danish model ("the woman stays - the tissue moves"). This is truly patient-centered medicine. We can have maximum effects with the minimum burden. A transportation network like those of Denmark and Germany is the best strategy for FP in Japan. It may be the best system for cancer patients, medical staff, and the Ministry of Health, Labor, and Welfare.

  16. Novel Discrete Compactness-Based Training for Vector Quantization Networks: Enhancing Automatic Brain Tissue Classification

    Directory of Open Access Journals (Sweden)

    Ricardo Pérez-Aguila

    2013-01-01

    Full Text Available An approach for nonsupervised segmentation of Computed Tomography (CT brain slices which is based on the use of Vector Quantization Networks (VQNs is described. Images are segmented via a VQN in such way that tissue is characterized according to its geometrical and topological neighborhood. The main contribution rises from the proposal of a similarity metric which is based on the application of Discrete Compactness (DC which is a factor that provides information about the shape of an object. One of its main strengths lies in the sense of its low sensitivity to variations, due to noise or capture defects, in the shape of an object. We will present, compare, and discuss some examples of segmentation networks trained under Kohonen’s original algorithm and also under our similarity metric. Some experiments are established in order to measure the effectiveness and robustness, under our application of interest, of the proposed networks and similarity metric.

  17. Singular structure of Mueller matrices images of biological crystal networks for diagnostic human tissues pathological changes

    Science.gov (United States)

    Sakhnovskiy, M. Y.; Ushenko, V. A.

    2013-09-01

    The process of converting of laser radiation by optically anisotropic crystals of biological networks are singular in the sense of total (simultaneous) of mechanisms of orientation and phase (birefringence) anisotropy the formation of polarization-inhomogeneous field of scattered radiation. This work is aimed at developing a method of polarization selection mechanisms of blood plasma polycrystalline networks anisotropy. The relationship between statistics, correlation and fractal parameters of polarization-inhomogeneous images of blood plasma and by linear dichroism and linear birefringence of polycrystalline networks albumin and globulin was found. The criteria of differentiation and diagnostic images of polarization-inhomogeneous plasma samples of the control group (donor) and a group of patients with malignant changes of breast tissue was identified.

  18. A network model of correlated growth of tissue stiffening in pulmonary fibrosis

    CERN Document Server

    Oliveira, Cláudio L N; Suki, Béla

    2013-01-01

    During the progression of pulmonary fibrosis, initially isolated regions of high stiffness form and grow in the lung tissue due to collagen deposition by fibroblast cells. We have previously shown that ongoing collagen deposition may not lead to significant increases in the bulk modulus of the lung until these local remodeled regions have become sufficiently numerous and extensive to percolate in a continuous path across the entire tissue [Bates {\\it et al.} 2007 {\\it Am. J. Respir. Crit. Care Med.} {\\bf 176} 617]. In the present study, we investigate whether spatial correlations influence the bulk modulus in a two-dimensional elastic network model of lung tissue. Random collagen deposition at a single site is modeled by increasing the elastic constant of the spring at that site by a factor of 100. By contrast, correlated collagen deposition is represented by stiffening the springs encountered along a random walk starting from some initial spring, the rationale being that excess collagen deposition is more li...

  19. Picrosirius red staining: a useful tool to appraise collagen networks in normal and pathological tissues.

    Science.gov (United States)

    Lattouf, Raed; Younes, Ronald; Lutomski, Didier; Naaman, Nada; Godeau, Gaston; Senni, Karim; Changotade, Sylvie

    2014-10-01

    Specific staining of the extracellular matrix components is especially helpful in studying tissue remodeling, particularly in the case of connective tissue pathologies. As developed by Junqueira and colleagues in 1979, specific staining by Picrosirius red is one of the most important stains to study collagen networks in different tissues. Under polarized light, collagen bundles appear green, red or yellow, and are easily differentiated from the black background, thus allowing for quantitative morphometric analysis. As Junqueira and colleagues point out, many studies use color staining to differentiate collagen bundles and to specify collagen types, yet other studies report that polarized colors only reflect fiber thickness and packing. Using a simple histological example, our study illustrates the inability of Picrosirius red staining to differentiate collagen types, since the absorbed amount of polarized light by this dye strictly depends on the orientation of the collagen bundles. © The Author(s) 2014.

  20. Binary tissue classification on wound images with neural networks and bayesian classifiers.

    Science.gov (United States)

    Veredas, Francisco; Mesa, Héctor; Morente, Laura

    2010-02-01

    A pressure ulcer is a clinical pathology of localized damage to the skin and underlying tissue caused by pressure, shear, or friction. Diagnosis, treatment, and care of pressure ulcers are costly for health services. Accurate wound evaluation is a critical task for optimizing the efficacy of treatment and care. Clinicians usually evaluate each pressure ulcer by visual inspection of the damaged tissues, which is an imprecise manner of assessing the wound state. Current computer vision approaches do not offer a global solution to this particular problem. In this paper, a hybrid approach based on neural networks and Bayesian classifiers is used in the design of a computational system for automatic tissue identification in wound images. A mean shift procedure and a region-growing strategy are implemented for effective region segmentation. Color and texture features are extracted from these segmented regions. A set of k multilayer perceptrons is trained with inputs consisting of color and texture patterns, and outputs consisting of categorical tissue classes which are determined by clinical experts. This training procedure is driven by a k-fold cross-validation method. Finally, a Bayesian committee machine is formed by training a Bayesian classifier to combine the classifications of the k neural networks. Specific heuristics based on the wound topology are designed to significantly improve the results of the classification. We obtain high efficiency rates from a binary cascade approach for tissue identification. Results are compared with other similar machine-learning approaches, including multiclass Bayesian committee machine classifiers and support vector machines. The different techniques analyzed in this paper show high global classification accuracy rates. Our binary cascade approach gives high global performance rates (average sensitivity =78.7% , specificity =94.7% , and accuracy =91.5% ) and shows the highest average sensitivity score ( =86.3%) when detecting

  1. Hydrogels of collagen/chondroitin sulfate/hyaluronan interpenetrating polymer network for cartilage tissue engineering.

    Science.gov (United States)

    Guo, Yan; Yuan, Tun; Xiao, Zhanwen; Tang, Pingping; Xiao, Yumei; Fan, Yujiang; Zhang, Xingdong

    2012-09-01

    The network structure of a three-dimensional hydrogel scaffold dominates its performance such as mechanical strength, mass transport capacity, degradation rate and subsequent cellular behavior. The hydrogels scaffolds with interpenetrating polymeric network (IPN) structure have an advantage over the individual component gels and could simulate partly the structure of native extracellular matrix of cartilage tissue. In this study, to develop perfect cartilage tissue engineering scaffolds, IPN hydrogels of collagen/chondroitin sulfate/hyaluronan were prepared via two simultaneous processes of collagen self-assembly and cross linking polymerization of chondroitin sulfate-methacrylate (CSMA) and hyaluronic acid-methacrylate. The degradation rate, swelling performance and compressive modulus of IPN hydrogels could be adjusted by varying the degree of methacrylation of CSMA. The results of proliferation and fluorescence staining of rabbit articular chondrocytes in vitro culture demonstrated that the IPN hydrogels possessed good cytocompatibility. Furthermore, the IPN hydrogels could upregulate cartilage-specific gene expression and promote the chondrocytes secreting glycosaminoglycan and collagen II. These results suggested that IPN hydrogels might serve as promising hydrogel scaffolds for cartilage tissue engineering.

  2. Evaluation of Fibrin-Based Interpenetrating Polymer Networks as Potential Biomaterials for Tissue Engineering

    Directory of Open Access Journals (Sweden)

    Olfat Gsib

    2017-12-01

    Full Text Available Interpenetrating polymer networks (IPNs have gained great attention for a number of biomedical applications due to their improved properties compared to individual components alone. In this study, we investigated the capacity of newly-developed naturally-derived IPNs as potential biomaterials for tissue engineering. These IPNs combine the biologic properties of a fibrous fibrin network polymerized at the nanoscale and the mechanical stability of polyethylene oxide (PEO. First, we assessed their cytotoxicity in vitro on L929 fibroblasts. We further evaluated their biocompatibility ex vivo with a chick embryo organotypic culture model. Subcutaneous implantations of the matrices were subsequently conducted on nude mice to investigate their biocompatibility in vivo. Our preliminary data highlighted that our biomaterials were non-cytotoxic (viability above 90%. The organotypic culture showed that the IPN matrices induced higher cell adhesion (across all the explanted organ tissues and migration (skin, intestine than the control groups, suggesting the advantages of using a biomimetic, yet mechanically-reinforced IPN-based matrix. We observed no major inflammatory response up to 12 weeks post implantation. All together, these data suggest that these fibrin-based IPNs are promising biomaterials for tissue engineering.

  3. THOMAS BERNHARD: DESTROYED THOUGHT AND REVIVED SUBJECT

    Directory of Open Access Journals (Sweden)

    Helano Jader Ribeiro

    2010-07-01

    Full Text Available This article aims to set a discussion about the book of Austrian writer Thomas Bernhard, Extinction, with regard to the legacy of the Nazi destruction of thought. The closing speech that Thomas Bernhard could also be read as an extinction of thought on behalf of a silence typical of those who survived and / or worked in concentration camps. Much has been written about Auschwitz, but the need to continue with all kinds of questions ethical, political or legal is an obligation of humanity itself.

  4. Human gene coexpression landscape: confident network derived from tissue transcriptomic profiles.

    Directory of Open Access Journals (Sweden)

    Carlos Prieto

    Full Text Available BACKGROUND: Analysis of gene expression data using genome-wide microarrays is a technique often used in genomic studies to find coexpression patterns and locate groups of co-transcribed genes. However, most studies done at global "omic" scale are not focused on human samples and when they correspond to human very often include heterogeneous datasets, mixing normal with disease-altered samples. Moreover, the technical noise present in genome-wide expression microarrays is another well reported problem that many times is not addressed with robust statistical methods, and the estimation of errors in the data is not provided. METHODOLOGY/PRINCIPAL FINDINGS: Human genome-wide expression data from a controlled set of normal-healthy tissues is used to build a confident human gene coexpression network avoiding both pathological and technical noise. To achieve this we describe a new method that combines several statistical and computational strategies: robust normalization and expression signal calculation; correlation coefficients obtained by parametric and non-parametric methods; random cross-validations; and estimation of the statistical accuracy and coverage of the data. All these methods provide a series of coexpression datasets where the level of error is measured and can be tuned. To define the errors, the rates of true positives are calculated by assignment to biological pathways. The results provide a confident human gene coexpression network that includes 3327 gene-nodes and 15841 coexpression-links and a comparative analysis shows good improvement over previously published datasets. Further functional analysis of a subset core network, validated by two independent methods, shows coherent biological modules that share common transcription factors. The network reveals a map of coexpression clusters organized in well defined functional constellations. Two major regions in this network correspond to genes involved in nuclear and mitochondrial

  5. In Vitro Construction of Scaffold-Free Bilayered Tissue-Engineered Skin Containing Capillary Networks

    Directory of Open Access Journals (Sweden)

    Yuan Liu

    2013-01-01

    Full Text Available Many types of skin substitutes have been constructed using exogenous materials. Angiogenesis is an important factor for tissue-engineered skin constructs. In this study, we constructed a scaffold-free bilayered tissue-engineered skin containing a capillary network. First, we cocultured dermal fibroblasts with dermal microvascular endothelial cells at a ratio of 2 : 1. A fibrous sheet was formed by the interactions between the fibroblasts and the endothelial cells, and capillary-like structures were observed after 20 days of coculture. Epithelial cells were then seeded on the fibrous sheet to assemble the bilayered tissue. HE staining showed that tissue-engineered skin exhibited a stratified epidermis after 7 days. Immunostaining showed that the epithelium promoted the formation of capillary-like structures. Transmission electron microscopy (TEM analysis showed that the capillary-like structures were typical microblood vessels. ELISA demonstrated that vascularization was promoted by significant upregulation of vascularization associated growth factors due to interactions among the 3 types of cells in the bilayer, as compared to cocultures of fibroblast and endothelial cells and monocultures.

  6. Dynamic Proteomic Characteristics and Network Integration Revealing Key Proteins for Two Kernel Tissue Developments in Popcorn.

    Directory of Open Access Journals (Sweden)

    Yongbin Dong

    Full Text Available The formation and development of maize kernel is a complex dynamic physiological and biochemical process that involves the temporal and spatial expression of many proteins and the regulation of metabolic pathways. In this study, the protein profiles of the endosperm and pericarp at three important developmental stages were analyzed by isobaric tags for relative and absolute quantification (iTRAQ labeling coupled with LC-MS/MS in popcorn inbred N04. Comparative quantitative proteomic analyses among developmental stages and between tissues were performed, and the protein networks were integrated. A total of 6,876 proteins were identified, of which 1,396 were nonredundant. Specific proteins and different expression patterns were observed across developmental stages and tissues. The functional annotation of the identified proteins revealed the importance of metabolic and cellular processes, and binding and catalytic activities for the development of the tissues. The whole, endosperm-specific and pericarp-specific protein networks integrated 125, 9 and 77 proteins, respectively, which were involved in 54 KEGG pathways and reflected their complex metabolic interactions. Confirmation for the iTRAQ endosperm proteins by two-dimensional gel electrophoresis showed that 44.44% proteins were commonly found. However, the concordance between mRNA level and the protein abundance varied across different proteins, stages, tissues and inbred lines, according to the gene cloning and expression analyses of four relevant proteins with important functions and different expression levels. But the result by western blot showed their same expression tendency for the four proteins as by iTRAQ. These results could provide new insights into the developmental mechanisms of endosperm and pericarp, and grain formation in maize.

  7. Dynamic Proteomic Characteristics and Network Integration Revealing Key Proteins for Two Kernel Tissue Developments in Popcorn.

    Science.gov (United States)

    Dong, Yongbin; Wang, Qilei; Zhang, Long; Du, Chunguang; Xiong, Wenwei; Chen, Xinjian; Deng, Fei; Ma, Zhiyan; Qiao, Dahe; Hu, Chunhui; Ren, Yangliu; Li, Yuling

    2015-01-01

    The formation and development of maize kernel is a complex dynamic physiological and biochemical process that involves the temporal and spatial expression of many proteins and the regulation of metabolic pathways. In this study, the protein profiles of the endosperm and pericarp at three important developmental stages were analyzed by isobaric tags for relative and absolute quantification (iTRAQ) labeling coupled with LC-MS/MS in popcorn inbred N04. Comparative quantitative proteomic analyses among developmental stages and between tissues were performed, and the protein networks were integrated. A total of 6,876 proteins were identified, of which 1,396 were nonredundant. Specific proteins and different expression patterns were observed across developmental stages and tissues. The functional annotation of the identified proteins revealed the importance of metabolic and cellular processes, and binding and catalytic activities for the development of the tissues. The whole, endosperm-specific and pericarp-specific protein networks integrated 125, 9 and 77 proteins, respectively, which were involved in 54 KEGG pathways and reflected their complex metabolic interactions. Confirmation for the iTRAQ endosperm proteins by two-dimensional gel electrophoresis showed that 44.44% proteins were commonly found. However, the concordance between mRNA level and the protein abundance varied across different proteins, stages, tissues and inbred lines, according to the gene cloning and expression analyses of four relevant proteins with important functions and different expression levels. But the result by western blot showed their same expression tendency for the four proteins as by iTRAQ. These results could provide new insights into the developmental mechanisms of endosperm and pericarp, and grain formation in maize.

  8. Tissue microstructure estimation using a deep network inspired by a dictionary-based framework.

    Science.gov (United States)

    Ye, Chuyang

    2017-12-01

    Diffusion magnetic resonance imaging (dMRI) captures the anisotropic pattern of water displacement in the neuronal tissue and allows noninvasive investigation of the complex tissue microstructure. A number of biophysical models have been proposed to relate the tissue organization with the observed diffusion signals, so that the tissue microstructure can be inferred. The Neurite Orientation Dispersion and Density Imaging (NODDI) model has been a popular choice and has been widely used for many neuroscientific studies. It models the diffusion signal with three compartments that are characterized by distinct diffusion properties, and the parameters in the model describe tissue microstructure. In NODDI, these parameters are estimated in a maximum likelihood framework, where the nonlinear model fitting is computationally intensive. Therefore, efforts have been made to develop efficient and accurate algorithms for NODDI microstructure estimation, which is still an open problem. In this work, we propose a deep network based approach that performs end-to-end estimation of NODDI microstructure, which is named Microstructure Estimation using a Deep Network (MEDN). MEDN comprises two cascaded stages and is motivated by the AMICO algorithm, where the NODDI microstructure estimation is formulated in a dictionary-based framework. The first stage computes the coefficients of the dictionary. It resembles the solution to a sparse reconstruction problem, where the iterative process in conventional estimation approaches is unfolded and truncated, and the weights are learned instead of predetermined by the dictionary. In the second stage, microstructure properties are computed from the output of the first stage, which resembles the weighted sum of normalized dictionary coefficients in AMICO, and the weights are also learned. Because spatial consistency of diffusion signals can be used to reduce the effect of noise, we also propose MEDN+, which is an extended version of MEDN. MEDN

  9. Thomas Jesse Jones, Social Studies, and Race.

    Science.gov (United States)

    Watkins, William H.

    1996-01-01

    Discusses the character and contributions of Thomas Jesse Jones, an early 20th-century educator and a pioneer in social studies and black education. Jones's inconsistent philosophy (he supported limited black education but believed in white supremacy) grew out of an unlikely combination of progressive Christianity and deep conservatism. (MJP)

  10. Thomas Jefferson and the Politics of Education.

    Science.gov (United States)

    Wagoner, Jennings L., Jr.

    Thomas Jefferson considered the founding of the University of Virginia one of the most important accomplishments of his life. So revered is Jefferson today that one might assume that Virginia legislators enthusiastically supported his suggestions for the founding of the university. Rather, his suggestions were resisted and it was necessary for him…

  11. Strategies: The Thomas Jefferson University Model.

    Science.gov (United States)

    Forrest, Jane L.

    1991-01-01

    Thomas Jefferson University (Pennsylvania) has two dental professional hygiene education programs, one a prelicensure, entry-level clinical education program and the other a postcertificate or baccalaureate degree completion program. Recruitment strategies include prerequisite restructuring and part-time programs, and retention efforts begin with…

  12. Thomas Jefferson versus Wellesley High School.

    Science.gov (United States)

    Loss, Richard

    1983-01-01

    One reason for the concern with high schools is that their performance limits, sometimes severely, what the colleges and universities can accomplish. Thomas Jefferson's views of education are used as criteria to judge the quality of liberal education the author received from Wellesley (Massachusetts) High School. (RM)

  13. Thomas Jefferson and Architecture. Lesson Plan.

    Science.gov (United States)

    Gabriel, Robin H.

    1994-01-01

    Discusses the importance of architecture in Thomas Jefferson's life. Presents a lesson plan based on Jefferson's Monticello and designed to encourage students to identify and understand elements of classical architecture in their local area. Includes a photograph of Monticello and six architectural illustrations. (CFR)

  14. A Model Technology Educator: Thomas A. Edison

    Science.gov (United States)

    Pretzer, William S.; Rogers, George E.; Bush, Jeffery

    2007-01-01

    Reflecting back over a century ago to the small village of Menlo Park, New Jersey provides insight into a remarkable visionary and an exceptional role model for today's problem-solving and design-focused technology educator: Thomas A. Edison, inventor, innovator, and model technology educator. Since Edison could not simply apply existing knowledge…

  15. New Jersey's Thomas Edison and the fluoroscope.

    Science.gov (United States)

    Tselos, G D

    1995-11-01

    Thomas Edison played a major role in the development of early x-ray technology in 1896, notably increasing tube power and reliability and making the fluoroscope a practical instrument. Eventually, Edison would move x-ray technology from the laboratory to the marketplace.

  16. To: Thomas Jefferson. Re: Your Proposal.

    Science.gov (United States)

    Deyoe-Chiullan, Rita M.

    1993-01-01

    A tongue-in-check response claimed to be from the prime minister of England to Thomas Jefferson regarding the "Declaration of Independence." Claims that the declaration fails to meet recently adopted specifications for proposals to the Crown and lacks a line-item budget, citations from recent literature, and measurable goals. (MLF)

  17. Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.

    Science.gov (United States)

    Inouye, Michael; Ripatti, Samuli; Kettunen, Johannes; Lyytikäinen, Leo-Pekka; Oksala, Niku; Laurila, Pirkka-Pekka; Kangas, Antti J; Soininen, Pasi; Savolainen, Markku J; Viikari, Jorma; Kähönen, Mika; Perola, Markus; Salomaa, Veikko; Raitakari, Olli; Lehtimäki, Terho; Taskinen, Marja-Riitta; Järvelin, Marjo-Riitta; Ala-Korpela, Mika; Palotie, Aarno; de Bakker, Paul I W

    2012-01-01

    Association testing of multiple correlated phenotypes offers better power than univariate analysis of single traits. We analyzed 6,600 individuals from two population-based cohorts with both genome-wide SNP data and serum metabolomic profiles. From the observed correlation structure of 130 metabolites measured by nuclear magnetic resonance, we identified 11 metabolic networks and performed a multivariate genome-wide association analysis. We identified 34 genomic loci at genome-wide significance, of which 7 are novel. In comparison to univariate tests, multivariate association analysis identified nearly twice as many significant associations in total. Multi-tissue gene expression studies identified variants in our top loci, SERPINA1 and AQP9, as eQTLs and showed that SERPINA1 and AQP9 expression in human blood was associated with metabolites from their corresponding metabolic networks. Finally, liver expression of AQP9 was associated with atherosclerotic lesion area in mice, and in human arterial tissue both SERPINA1 and AQP9 were shown to be upregulated (6.3-fold and 4.6-fold, respectively) in atherosclerotic plaques. Our study illustrates the power of multi-phenotype GWAS and highlights candidate genes for atherosclerosis.

  18. Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.

    Directory of Open Access Journals (Sweden)

    Michael Inouye

    Full Text Available Association testing of multiple correlated phenotypes offers better power than univariate analysis of single traits. We analyzed 6,600 individuals from two population-based cohorts with both genome-wide SNP data and serum metabolomic profiles. From the observed correlation structure of 130 metabolites measured by nuclear magnetic resonance, we identified 11 metabolic networks and performed a multivariate genome-wide association analysis. We identified 34 genomic loci at genome-wide significance, of which 7 are novel. In comparison to univariate tests, multivariate association analysis identified nearly twice as many significant associations in total. Multi-tissue gene expression studies identified variants in our top loci, SERPINA1 and AQP9, as eQTLs and showed that SERPINA1 and AQP9 expression in human blood was associated with metabolites from their corresponding metabolic networks. Finally, liver expression of AQP9 was associated with atherosclerotic lesion area in mice, and in human arterial tissue both SERPINA1 and AQP9 were shown to be upregulated (6.3-fold and 4.6-fold, respectively in atherosclerotic plaques. Our study illustrates the power of multi-phenotype GWAS and highlights candidate genes for atherosclerosis.

  19. Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice

    Directory of Open Access Journals (Sweden)

    Karl Andrew Rodriguez

    2014-11-01

    Full Text Available Rapamycin, an allosteric inhibitor of the mTOR kinase, increases longevity in mice in a sex-specific manner. In contrast to the widely accepted theory that a loss of proteasome activity is detrimental to both life- and healthspan, biochemical studies in vitro reveal that rapamycin inhibits 20S proteasome peptidase activity. We tested if this unexpected finding is also evident after chronic rapamycin treatment in vivo by measuring peptidase activities for both the 26S and 20S proteasome in liver, fat, and brain tissues of old, male and female mice fed encapsulated chow containing 2.24mg/kg (14 ppm rapamycin for 6 months. Further we assessed if rapamycin altered expression of the chaperone proteins known to interact with the proteasome-mediated degradation system (PMDS, heat shock factor 1 (HSF1, and the levels of key mTOR pathway proteins. Rapamycin had little effect on liver proteasome activity in either gender, but increased proteasome activity in female brain lysates and lowered its activity in female fat tissue. Rapamycin-induced changes in molecular chaperone levels were also more substantial in tissues from female animals. Furthermore, mTOR pathway proteins showed more significant changes in female tissues compared to those from males. These data show collectively that there are divergent tissue and sex effects of rapamycin on the proteasome-chaperone network and that these may be linked to the disparate effects of rapamycin on males and females. Further our findings suggest that rapamycin induces indirect regulation of the PMDS/heat-shock response through its modulation of the mTOR pathway rather than via direct interactions between rapamycin and the proteasome.

  20. RNA sequencing identifies gene regulatory networks controlling extracellular matrix synthesis in intervertebral disk tissues.

    Science.gov (United States)

    Riester, Scott M; Lin, Yang; Wang, Wei; Cong, Lin; Mohamed Ali, Abdel-Moneim; Peck, Sun H; Smith, Lachlan J; Currier, Bradford L; Clark, Michelle; Huddleston, Paul; Krauss, William; Yaszemski, Michael J; Morrey, Mark E; Abdel, Matthew P; Bydon, Mohamad; Qu, Wenchun; Larson, Annalise N; van Wijnen, Andre J; Nassr, Ahmad

    2017-12-11

    Degenerative disk disease of the spine is a major cause of back pain and disability. Optimization of regenerative medical therapies for degenerative disk disease requires a deep mechanistic understanding of the factors controlling the structural integrity of spinal tissues. In this investigation, we sought to identify candidate regulatory genes controlling extracellular matrix synthesis in spinal tissues. To achieve this goal we performed high throughput next generation RNA sequencing on 39 annulus fibrosus and 21 nucleus pulposus human tissue samples. Specimens were collected from patients undergoing surgical discectomy for the treatment of degenerative disk disease. Our studies identified associations between extracellular matrix genes, growth factors, and other important regulatory molecules. The fibrous matrix characteristic of annulus fibrosus was associated with expression of the growth factors platelet derived growth factor beta (PDGFB), vascular endothelial growth factor C (VEGFC), and fibroblast growth factor 9 (FGF9). Additionally we observed high expression of multiple signaling proteins involved in the NOTCH and WNT signaling cascades. Nucleus pulposus extracellular matrix related genes were associated with the expression of numerous diffusible growth factors largely associated with the transforming growth signaling cascade, including transforming factor alpha (TGFA), inhibin alpha (INHA), inhibin beta A (INHBA), bone morphogenetic proteins (BMP2, BMP6), and others. this investigation provides important data on extracellular matrix gene regulatory networks in disk tissues. This information can be used to optimize pharmacologic, stem cell, and tissue engineering strategies for regeneration of the intervertebral disk and the treatment of back pain. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

  1. LiDAR Relative Reflectivity Surface (2011) for the St. Thomas East End Reserve, St. Thomas

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a LiDAR (Light Detection & Ranging) 0.3x0.3 meter resolution relative seafloor reflectivity surface for the St. Thomas East End Reserve...

  2. Digital 3D reconstructions using histological serial sections of lung tissue including the alveolar capillary network.

    Science.gov (United States)

    Grothausmann, Roman; Knudsen, Lars; Ochs, Matthias; Mühlfeld, Christian

    2017-02-01

    Grothausmann R, Knudsen L, Ochs M, Mühlfeld C. Digital 3D reconstructions using histological serial sections of lung tissue including the alveolar capillary network. Am J Physiol Lung Cell Mol Physiol 312: L243-L257, 2017. First published December 2, 2016; doi:10.1152/ajplung.00326.2016-The alveolar capillary network (ACN) provides an enormously large surface area that is necessary for pulmonary gas exchange. Changes of the ACN during normal or pathological development or in pulmonary diseases are of great functional impact and warrant further analysis. Due to the complexity of the three-dimensional (3D) architecture of the ACN, 2D approaches are limited in providing a comprehensive impression of the characteristics of the normal ACN or the nature of its alterations. Stereological methods offer a quantitative way to assess the ACN in 3D in terms of capillary volume, surface area, or number but lack a 3D visualization to interpret the data. Hence, the necessity to visualize the ACN in 3D and to correlate this with data from the same set of data arises. Such an approach requires a large sample volume combined with a high resolution. Here, we present a technically simple and cost-efficient approach to create 3D representations of lung tissue ranging from bronchioles over alveolar ducts and alveoli up to the ACN from more than 1 mm sample extent to a resolution of less than 1 μm. The method is based on automated image acquisition of serially sectioned epoxy resin-embedded lung tissue fixed by vascular perfusion and subsequent automated digital reconstruction and analysis of the 3D data. This efficient method may help to better understand mechanisms of vascular development and pathology of the lung. Copyright © 2017 the American Physiological Society.

  3. Wideband phantoms of different body tissues for heterogeneous models in body area networks.

    Science.gov (United States)

    Castello-Palacios, Sergio; Garcia-Pardo, Concepcion; Fornes-Leal, Alejandro; Cardona, Narcis; Valles-Lluch, Ana

    2017-07-01

    One of the key issues about wireless technologies is their interaction with the human body. The so-called internet of things will comprise many devices that will transmit either around or through the human body. These devices must be tested either in their working medium, when possible, or in the most realistic one. For this purpose, tissue-like phantoms are the best alternative to carry out realistic analyses of the performance of body area networks. In addition, they are the conventional way to certify the compliance of commercial standards by these devices. However, the number of phantoms that work in large bandwidths is limited in literature. This work aims at presenting chemical solutions that will be useful to prepare a variety of wideband tissue phantoms. Besides, the colon was mimicked in two ways, the healthy tissue and the malignant one, taking into account studies that relate changes on the relative permittivity with cancer. They were designed on the basis of acetonitrile in aqueous solutions as described in a previous work. Thus, many scenarios could be developed such as multilayers which imitate parts of the heterogeneous body.

  4. Museum security and the Thomas Crown Affair.

    Energy Technology Data Exchange (ETDEWEB)

    Michaud, E. C. (Nuclear Engineering Division)

    2010-01-01

    unauthorized piece he created and placed in the British Museum known as 'Early Man Goes to Market' received different treatment when placed inside the walls. It was adopted into the permanent collection! I like his story because it's so counter-intuitive. Who would have thought that modern museum security might involve preventing people not just from stealing art, but from sneaking 'unauthorized' art into museums? What is next, tampering with the archive records in order to make it look like the piece in question has always been there? To learn more about museum security, I interviewed multiple experts in the field. It turns out that the glamorous lifestyle of Thomas Crown is not particularly relevant. In fact, usually nobody can point to a Mr. Big of the underworld coordinating thefts, though some organized crime families have been known to use stolen art as black market chips to trade. The common consensus among experts in the field of art theft is that, instead of most high-value pieces being stolen by outsiders with a blue print in hand and rappelling from a ceiling skylight, in reality, 80 percent of art thefts involve insiders or accomplices that execute the crime over a period of time while working or volunteering in the museum. Indeed, according to FBI statistics, between 70 and 80 percent of all solved art theft cases involve insider participation of some kind, yet according to Tom Cremers of the Musuem Security Network, 'Having been involved in risk assessments in over hundreds of museums over the past ten years, it is quite astonishing how rarely the risk of insider participation is discussed.' In regards to the insider threat, a museum is not much different from any corporation or other organization. There are directors, employees, interns, and cleaning staff (very often outsourced), security guards (again outsourced, typically with very high turnover rates). Unlike corporations, most museums also have volunteer staff, docents

  5. Rapid Alterations in Perirenal Adipose Tissue Transcriptomic Networks with Cessation of Voluntary Running.

    Directory of Open Access Journals (Sweden)

    Gregory N Ruegsegger

    Full Text Available In maturing rats, the growth of abdominal fat is attenuated by voluntary wheel running. After the cessation of running by wheel locking, a rapid increase in adipose tissue growth to a size that is similar to rats that have never run (i.e. catch-up growth has been previously reported by our lab. In contrast, diet-induced increases in adiposity have a slower onset with relatively delayed transcriptomic responses. The purpose of the present study was to identify molecular pathways associated with the rapid increase in adipose tissue after ending 6 wks of voluntary running at the time of puberty. Age-matched, male Wistar rats were given access to running wheels from 4 to 10 weeks of age. From the 10th to 11th week of age, one group of rats had continued wheel access, while the other group had one week of wheel locking. Perirenal adipose tissue was extracted, RNA sequencing was performed, and bioinformatics analyses were executed using Ingenuity Pathway Analysis (IPA. IPA was chosen to assist in the understanding of complex 'omics data by integrating data into networks and pathways. Wheel locked rats gained significantly more fat mass and significantly increased body fat percentage between weeks 10-11 despite having decreased food intake, as compared to rats with continued wheel access. IPA identified 646 known transcripts differentially expressed (p < 0.05 between continued wheel access and wheel locking. In wheel locked rats, IPA revealed enrichment of transcripts for the following functions: extracellular matrix, macrophage infiltration, immunity, and pro-inflammatory. These findings suggest that increases in visceral adipose tissue that accompanies the cessation of pubertal physical activity are associated with the alteration of multiple pathways, some of which may potentiate the development of pubertal obesity and obesity-associated systemic low-grade inflammation that occurs later in life.

  6. Rapid Alterations in Perirenal Adipose Tissue Transcriptomic Networks with Cessation of Voluntary Running.

    Science.gov (United States)

    Ruegsegger, Gregory N; Company, Joseph M; Toedebusch, Ryan G; Roberts, Christian K; Roberts, Michael D; Booth, Frank W

    2015-01-01

    In maturing rats, the growth of abdominal fat is attenuated by voluntary wheel running. After the cessation of running by wheel locking, a rapid increase in adipose tissue growth to a size that is similar to rats that have never run (i.e. catch-up growth) has been previously reported by our lab. In contrast, diet-induced increases in adiposity have a slower onset with relatively delayed transcriptomic responses. The purpose of the present study was to identify molecular pathways associated with the rapid increase in adipose tissue after ending 6 wks of voluntary running at the time of puberty. Age-matched, male Wistar rats were given access to running wheels from 4 to 10 weeks of age. From the 10th to 11th week of age, one group of rats had continued wheel access, while the other group had one week of wheel locking. Perirenal adipose tissue was extracted, RNA sequencing was performed, and bioinformatics analyses were executed using Ingenuity Pathway Analysis (IPA). IPA was chosen to assist in the understanding of complex 'omics data by integrating data into networks and pathways. Wheel locked rats gained significantly more fat mass and significantly increased body fat percentage between weeks 10-11 despite having decreased food intake, as compared to rats with continued wheel access. IPA identified 646 known transcripts differentially expressed (p rats, IPA revealed enrichment of transcripts for the following functions: extracellular matrix, macrophage infiltration, immunity, and pro-inflammatory. These findings suggest that increases in visceral adipose tissue that accompanies the cessation of pubertal physical activity are associated with the alteration of multiple pathways, some of which may potentiate the development of pubertal obesity and obesity-associated systemic low-grade inflammation that occurs later in life.

  7. 78 FR 23489 - Safety Zone; V.I. Carnival Finale, St. Thomas Harbor; St. Thomas, U.S.V.I.

    Science.gov (United States)

    2013-04-19

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; V.I. Carnival Finale, St. Thomas Harbor; St. Thomas, U.S.V.I. AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a safety zone on the waters of St. Thomas Harbor in St. Thomas, U.S. Virgin Islands during the V.I...

  8. St. Ap. Thomas and steps of faith

    Directory of Open Access Journals (Sweden)

    Nicolae Popescu

    2015-11-01

    Full Text Available There is, in folk tradition, an expression, “Doubting Thomas”, making an obvious allusion to doubts shown by St. Ap. Thomas against the other apostles’ testimonials of the resurrection of Jesus. But we prefer to say that St. Ap. Thomas doubted because he recognizes that the Saviour Himself “believed” only because he saw (Jn 20, 27. But pure faith denies doubt, (evidence shall rebuke the disciples of John, St. Ap. Thomas and the other apostles, who demanded an over-confirmation, and without guile, (showing the condemnation of the Pharisees, scribes and wicked generation, which together “sky sign”, and with aspects which the Saviour added:” Seeing, blessed are those who hear the word of God and obey it “(Lk 11: 28. The Beatitudes are the blessings of the Law of Love as the Commandments are applications of the Law of Moses. The doubt of St. Ap. Thomas, strikingly approaches the existential doubt of the whole being,(while the methodical doubt of Descartes was intellectual, scientists considered this the only legitimate way to access complete certainty. It is thrilling that Descartes wanted to be like a man, who moving through the darkness, and compelled to go slow and be circumspect in all things, as you would do to keep from falling. But he refused to accept any idea before it passed through his reason and without having sought simultaneously, a way to get to know everything that his spirit is capable of, and being like Adam, who wanted to reach deification by his own powers, without the gift of God.

  9. [Rezension zu:] Thomas Amos: Architectura cimmeria

    OpenAIRE

    Simonis, Annette

    2017-01-01

    Rezension zu Thomas Amos: Architectura cimmeria. Manie und Manier phantastischer Architektur in Jean Rays 'Malpertuis'. Heidelberg (Winter) 2006. 244 S. Die vorliegende Studie, eine Frankfurter Dissertation, beschäftigt sich mit der manieristischen Dimension von Jean Rays Roman 'Malpertuis' aus dem Jahre 1943 und beleuchtet dabei insbesondere die vielfaltigen Beziehungen des Textes zur bildenden Kunst und Architektur, die von der mittelalterlichen Baukunst über Piranesi bis Magritte reich...

  10. Prediction of disease-related genes based on weighted tissue-specific networks by using DNA methylation.

    Science.gov (United States)

    Li, Min; Zhang, Jiayi; Liu, Qing; Wang, Jianxin; Wu, Fang-Xiang

    2014-01-01

    Predicting disease-related genes is one of the most important tasks in bioinformatics and systems biology. With the advances in high-throughput techniques, a large number of protein-protein interactions are available, which make it possible to identify disease-related genes at the network level. However, network-based identification of disease-related genes is still a challenge as the considerable false-positives are still existed in the current available protein interaction networks (PIN). Considering the fact that the majority of genetic disorders tend to manifest only in a single or a few tissues, we constructed tissue-specific networks (TSN) by integrating PIN and tissue-specific data. We further weighed the constructed tissue-specific network (WTSN) by using DNA methylation as it plays an irreplaceable role in the development of complex diseases. A PageRank-based method was developed to identify disease-related genes from the constructed networks. To validate the effectiveness of the proposed method, we constructed PIN, weighted PIN (WPIN), TSN, WTSN for colon cancer and leukemia, respectively. The experimental results on colon cancer and leukemia show that the combination of tissue-specific data and DNA methylation can help to identify disease-related genes more accurately. Moreover, the PageRank-based method was effective to predict disease-related genes on the case studies of colon cancer and leukemia. Tissue-specific data and DNA methylation are two important factors to the study of human diseases. The same method implemented on the WTSN can achieve better results compared to those being implemented on original PIN, WPIN, or TSN. The PageRank-based method outperforms degree centrality-based method for identifying disease-related genes from WTSN.

  11. Active tension network model suggests an exotic mechanical state realized in epithelial tissues

    Science.gov (United States)

    Noll, Nicholas; Mani, Madhav; Heemskerk, Idse; Streichan, Sebastian J.; Shraiman, Boris I.

    2017-12-01

    Mechanical interactions play a crucial role in epithelial morphogenesis, yet understanding the complex mechanisms through which stress and deformation affect cell behaviour remains an open problem. Here we formulate and analyse the active tension network (ATN) model, which assumes that the mechanical balance of cells within a tissue is dominated by cortical tension and introduces tension-dependent active remodelling of the cortex. We find that ATNs exhibit unusual mechanical properties. Specifically, an ATN behaves as a fluid at short times, but at long times supports external tension like a solid. Furthermore, an ATN has an extensively degenerate equilibrium mechanical state associated with a discrete conformal--`isogonal'--deformation of cells. The ATN model predicts a constraint on equilibrium cell geometries, which we demonstrate to approximately hold in certain epithelial tissues. We further show that isogonal modes are observed in the fruit fly embryo, accounting for the striking variability of apical areas of ventral cells and helping understand the early phase of gastrulation. Living matter realizes new and exotic mechanical states, the study of which helps to understand biological phenomena.

  12. Bayesian state space models for dynamic genetic network construction across multiple tissues.

    Science.gov (United States)

    Liang, Yulan; Kelemen, Arpad

    2016-08-01

    Construction of gene-gene interaction networks and potential pathways is a challenging and important problem in genomic research for complex diseases while estimating the dynamic changes of the temporal correlations and non-stationarity are the keys in this process. In this paper, we develop dynamic state space models with hierarchical Bayesian settings to tackle this challenge for inferring the dynamic profiles and genetic networks associated with disease treatments. We treat both the stochastic transition matrix and the observation matrix time-variant and include temporal correlation structures in the covariance matrix estimations in the multivariate Bayesian state space models. The unevenly spaced short time courses with unseen time points are treated as hidden state variables. Hierarchical Bayesian approaches with various prior and hyper-prior models with Monte Carlo Markov Chain and Gibbs sampling algorithms are used to estimate the model parameters and the hidden state variables. We apply the proposed Hierarchical Bayesian state space models to multiple tissues (liver, skeletal muscle, and kidney) Affymetrix time course data sets following corticosteroid (CS) drug administration. Both simulation and real data analysis results show that the genomic changes over time and gene-gene interaction in response to CS treatment can be well captured by the proposed models. The proposed dynamic Hierarchical Bayesian state space modeling approaches could be expanded and applied to other large scale genomic data, such as next generation sequence (NGS) combined with real time and time varying electronic health record (EHR) for more comprehensive and robust systematic and network based analysis in order to transform big biomedical data into predictions and diagnostics for precision medicine and personalized healthcare with better decision making and patient outcomes.

  13. A network model of correlated growth of tissue stiffening in pulmonary fibrosis

    Science.gov (United States)

    Oliveira, Cláudio L. N.; Bates, Jason H. T.; Suki, Béla

    2014-06-01

    During the progression of pulmonary fibrosis, initially isolated regions of high stiffness form and grow in the lung tissue due to collagen deposition by fibroblast cells. We have previously shown that ongoing collagen deposition may not lead to significant increases in the bulk modulus of the lung until these local remodeled regions have become sufficiently numerous and extensive to percolate in a continuous path across the entire tissue (Bates et al 2007 Am. J. Respir. Crit. Care Med. 176 617). This model, however, did not include the possibility of spatially correlated deposition of collagen. In the present study, we investigate whether spatial correlations influence the bulk modulus in a two-dimensional elastic network model of lung tissue. Random collagen deposition at a single site is modeled by increasing the elastic constant of the spring at that site by a factor of 100. By contrast, correlated collagen deposition is represented by stiffening the springs encountered along a random walk starting from some initial spring, the rationale being that excess collagen deposition is more likely in the vicinity of an already stiff region. A combination of random and correlated deposition is modeled by performing random walks of length N from randomly selected initial sites, the balance between the two processes being determined by N. We found that the dependence of bulk modulus, B(N,c), on both N and the fraction of stiff springs, c, can be described by a strikingly simple set of empirical equations. For c0.8, B(N,c) is linear in c and independent of N, such that B(N,c)=100\\;{{B}_{0}}-100{{a}_{III}}(1-c){{B}_{0}}, where {{a}_{III}}=2.857. For small concentrations, the physiologically most relevant regime, the forces in the network springs are distributed according to a power law. When c = 0.3, the exponent of this power law increases from -4.5, when N = 1, and saturates to about -2, as N increases above 40. These results suggest that the spatial correlation of

  14. Discriminating solitary cysts from soft tissue lesions in mammography using a pretrained deep convolutional neural network.

    Science.gov (United States)

    Kooi, Thijs; van Ginneken, Bram; Karssemeijer, Nico; den Heeten, Ard

    2017-03-01

    It is estimated that 7% of women in the western world will develop palpable breast cysts in their lifetime. Even though cysts have been correlated with risk of developing breast cancer, many of them are benign and do not require follow-up. We develop a method to discriminate benign solitary cysts from malignant masses in digital mammography. We think a system like this can have merit in the clinic as a decision aid or complementary to specialized modalities. We employ a deep convolutional neural network (CNN) to classify cyst and mass patches. Deep CNNs have been shown to be powerful classifiers, but need a large amount of training data for which medical problems are often difficult to come by. The key contribution of this paper is that we show good performance can be obtained on a small dataset by pretraining the network on a large dataset of a related task. We subsequently investigate the following: (a) when a mammographic exam is performed, two different views of the same breast are recorded. We investigate the merit of combining the output of the classifier from these two views. (b) We evaluate the importance of the resolution of the patches fed to the network. (c) A method dubbed tissue augmentation is subsequently employed, where we extract normal tissue from normal patches and superimpose this onto the actual samples aiming for a classifier invariant to occluding tissue. (d) We combine the representation extracted using the deep CNN with our previously developed features. We show that using the proposed deep learning method, an area under the ROC curve (AUC) value of 0.80 can be obtained on a set of benign solitary cysts and malignant mass findings recalled in screening. We find that it works significantly better than our previously developed approach by comparing the AUC of the ROC using bootstrapping. By combining views, the results can be further improved, though this difference was not found to be significant. We find no significant difference between

  15. Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes

    DEFF Research Database (Denmark)

    Min, Josine L; Nicholson, George; Halgrimsdottir, Ingileif

    2012-01-01

    Metabolic Syndrome (MetS) is highly prevalent and has considerable public health impact, but its underlying genetic factors remain elusive. To identify gene networks involved in MetS, we conducted whole-genome expression and genotype profiling on abdominal (ABD) and gluteal (GLU) adipose tissue, ...

  16. Development of Electrically Conductive Double-Network Hydrogels via One-Step Facile Strategy for Cardiac Tissue Engineering.

    Science.gov (United States)

    Yang, Boguang; Yao, Fanglian; Hao, Tong; Fang, Wancai; Ye, Lei; Zhang, Yabin; Wang, Yan; Li, Junjie; Wang, Changyong

    2016-02-18

    Cardiac tissue engineering is an effective method to treat the myocardial infarction. However, the lack of electrical conductivity of biomaterials limits their applications. In this work, a homogeneous electronically conductive double network (HEDN) hydrogel via one-step facile strategy is developed, consisting of a rigid/hydrophobic/conductive network of chemical crosslinked poly(thiophene-3-acetic acid) (PTAA) and a flexible/hydrophilic/biocompatible network of photo-crosslinking methacrylated aminated gelatin (MAAG). Results suggest that the swelling, mechanical, and conductive properties of HEDN hydrogel can be modulated via adjusting the ratio of PTAA network to MAAG network. HEDN hydrogel has Young's moduli ranging from 22.7 to 493.1 kPa, and its conductivity (≈10(-4) S cm(-1)) falls in the range of reported conductivities for native myocardium tissue. To assess their biological activity, the brown adipose-derived stem cells (BADSCs) are seeded on the surface of HEDN hydrogel with or without electrical stimulation. Our data show that the HEDN hydrogel can support the survival and proliferation of BADSCs, and that it can improve the cardiac differentiation efficiency of BADSCs and upregulate the expression of connexin 43. Moreover, electrical stimulation can further improve this effect. Overall, it is concluded that the HEDN hydrogel may represent an ideal scaffold for cardiac tissue engineering. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Thomas Edison’s Poetry Machine

    OpenAIRE

    Rubery, Matthew

    2014-01-01

    The tradition of spoken-word recording began with Thomas Edison’s invention of the phonograph. Hence, this article makes the case that 1878 is a more important year to the history of literature than has yet been recognized for its experiments with verse and sound-recording technology. Although the tinfoil phonograph’s first decade has been well documented by media historians, literary critics have singled out 1888 as the noteworthy year since that is when Edison’s improved phonograph made it ...

  18. Localized Donaldson-Thomas theory of surfaces

    DEFF Research Database (Denmark)

    Gholampour, Amin; Sheshmani, Artan; Yau, Shing-Tung

    2017-01-01

    Let S be a projective simply connected complex surface and  be a line bundle on S. We study the moduli space of stable compactly supported 2-dimensional sheaves on the total spaces of . The moduli space admits a ℂ∗-action induced by scaling the fibers of . We identify certain components of the......  is the canonical bundle of S, the Vafa-Witten invariants defined recently by Tanaka-Thomas, can be extracted from these localized DT invariants. VW invariants are expected to have modular properties as predicted by S-duality....

  19. St. Thomas and the hilemorfic ontology

    Directory of Open Access Journals (Sweden)

    Lawrence Dewan, O.P.

    2009-06-01

    Full Text Available This article presents the relevancy of Aristotle’s hylemorphic ontology.Aristotle himself highlighted the importance and astonishing complexityof the problem of prime matter’s ontological status and he presenting thesolution in his doctrine of hylemorphism. As Saint Thomas Aquinasnoted, it is a crucial issue for philosophy because all four, hilemorfism,logic, physics and metaphysics, stand or fall depending on a correctunderstanding of the ontology of prime matter and of the kind of causalrelationship which exist between prime matter and substantial form ingenerable and corruptible substance.

  20. Advanced biomaterial strategies to transplant preformed micro-tissue engineered neural networks into the brain

    Science.gov (United States)

    Harris, J. P.; Struzyna, L. A.; Murphy, P. L.; Adewole, D. O.; Kuo, E.; Cullen, D. K.

    2016-02-01

    Objective. Connectome disruption is a hallmark of many neurological diseases and trauma with no current strategies to restore lost long-distance axonal pathways in the brain. We are creating transplantable micro-tissue engineered neural networks (micro-TENNs), which are preformed constructs consisting of embedded neurons and long axonal tracts to integrate with the nervous system to physically reconstitute lost axonal pathways. Approach. We advanced micro-tissue engineering techniques to generate micro-TENNs consisting of discrete populations of mature primary cerebral cortical neurons spanned by long axonal fascicles encased in miniature hydrogel micro-columns. Further, we improved the biomaterial encasement scheme by adding a thin layer of low viscosity carboxymethylcellulose (CMC) to enable needle-less insertion and rapid softening for mechanical similarity with brain tissue. Main results. The engineered architecture of cortical micro-TENNs facilitated robust neuronal viability and axonal cytoarchitecture to at least 22 days in vitro. Micro-TENNs displayed discrete neuronal populations spanned by long axonal fasciculation throughout the core, thus mimicking the general systems-level anatomy of gray matter—white matter in the brain. Additionally, micro-columns with thin CMC-coating upon mild dehydration were able to withstand a force of 893 ± 457 mN before buckling, whereas a solid agarose cylinder of similar dimensions was predicted to withstand less than 150 μN of force. This thin CMC coating increased the stiffness by three orders of magnitude, enabling needle-less insertion into brain while significantly reducing the footprint of previous needle-based delivery methods to minimize insertion trauma. Significance. Our novel micro-TENNs are the first strategy designed for minimally invasive implantation to facilitate nervous system repair by simultaneously providing neuronal replacement and physical reconstruction of long-distance axon pathways in the brain

  1. Principal Component Surface (2011) for St. Thomas East End Reserve, St. Thomas

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a 0.3x0.3 meter principal component analysis (PCA) surface for areas the St. Thomas East End Reserve (STEER) in the U.S. Virgin Islands (USVI)....

  2. Laser sintering fabrication of three-dimensional tissue engineering scaffolds with a flow channel network.

    Science.gov (United States)

    Niino, T; Hamajima, D; Montagne, K; Oizumi, S; Naruke, H; Huang, H; Sakai, Y; Kinoshita, H; Fujii, T

    2011-09-01

    The fabrication of tissue engineering scaffolds for the reconstruction of highly oxygen-dependent inner organs is discussed. An additive manufacturing technology known as selective laser sintering was employed to fabricate a highly porous scaffold with an embedded flow channel network. A porogen leaching system was used to obtain high porosity. A prototype was developed using the biodegradable plastic polycaprolactone and sodium chloride as the porogen. A high porosity of 90% was successfully obtained. Micro x-ray CT observation was carried out to confirm that channels with a diameter of approximately 1 mm were generated without clogging. The amount of residual salt was 930 µg while the overall volume of the scaffold was 13 cm(3), and it was confirmed that the toxicity of the salt was negligible. The hydrophilization of the scaffold to improve cell adhesion on the scaffold is also discussed. Oxygen plasma ashing and hydrolysis with sodium hydroxide, typically employed to improve the hydrophilicity of plastic surfaces, were tested. The improvement of hydrophilicity was confirmed by an increase in water retention by the porous scaffold from 180% to 500%.

  3. Active Tension Network model reveals an exotic mechanical state realized in epithelial tissues

    Science.gov (United States)

    Noll, Nicholas; Mani, Madhav; Heemskerk, Idse; Streicha, Sebastian; Shraiman, Boris

    Mechanical interactions play a crucial role in epithelial morphogenesis, yet understanding the complex mechanisms through which stress and deformation affect cell behavior remains an open problem. Here we formulate and analyze the Active Tension Network (ATN) model, which assumes that mechanical balance of cells is dominated by cortical tension and introduces tension dependent active remodeling of the cortex. We find that ATNs exhibit unusual mechanical properties: i) ATN behaves as a fluid at short times, but at long times it supports external tension, like a solid; ii) its mechanical equilibrium state has extensive degeneracy associated with a discrete conformal - ''isogonal'' - deformation of cells. ATN model predicts a constraint on equilibrium cell geometry, which we demonstrate to hold in certain epithelial tissues. We further show that isogonal modes are observed in a fruit fly embryo, accounting for the striking variability of apical area of ventral cells and helping understand the early phase of gastrulation. Living matter realizes new and exotic mechanical states, understanding which helps understand biological phenomena.

  4. The Pragmatics of Sir Thomas Bodley

    Directory of Open Access Journals (Sweden)

    Gabriella Mazzon

    2014-04-01

    Full Text Available The publication of the diplomatic correspondence of Sir Thomas Bodley online (Diplomatic Correspondence of Thomas Bodley, 1585 – 1597 offers a fine opportunity to study a text-type that is partly different from either business letters or personal correspondence. These texts lend themselves to be analysed from a sociopragmatic and discourse-analytic point of view, and this will be attempted in the paper by taking a closer look at the management of conflict, the degree of strength and directness of speech acts, and the ways in which social hierarchy is expressed. Several linguistic markers will be considered, in order to ascertain which elements can be seen as typically sensitive indicators in this particular text type, and how they relate to those found in other types of correspondence from the same period, which has been widely studied. In particular, the interplay between ‘diplomatic’ indirectness (also in the modern sense and direct reinforcement of personal bonds will be investigated; given the need to continuously express the element of personal trust, this type of correspondence seems particularly promising to analyse from this specific angle. Interesting insight can be gained by looking at the performing of specific acts or ‘moves’, for instance at the different levels of strength in directives, or at the linguistic means used to convey degrees of certainty in the reporting of information, both types of acts that figure prominently in these letters.

  5. MyProteinNet: build up-to-date protein interaction networks for organisms, tissues and user-defined contexts.

    Science.gov (United States)

    Basha, Omer; Flom, Dvir; Barshir, Ruth; Smoly, Ilan; Tirman, Shoval; Yeger-Lotem, Esti

    2015-07-01

    The identification of the molecular pathways active in specific contexts, such as disease states or drug responses, often requires an extensive view of the potential interactions between a subset of proteins. This view is not easily obtained: it requires the integration of context-specific protein list or expression data with up-to-date data of protein interactions that are typically spread across multiple databases. The MyProteinNet web server allows users to easily create such context-sensitive protein interaction networks. Users can automatically gather and consolidate data from up to 11 different databases to create a generic protein interaction network (interactome). They can score the interactions based on reliability and filter them by user-defined contexts including molecular expression and protein annotation. The output of MyProteinNet includes the generic and filtered interactome files, together with a summary of their network attributes. MyProteinNet is particularly geared toward building human tissue interactomes, by maintaining tissue expression profiles from multiple resources. The ability of MyProteinNet to facilitate the construction of up-to-date, context-specific interactomes and its applicability to 11 different organisms and to tens of human tissues, make it a powerful tool in meaningful analysis of protein networks. MyProteinNet is available at http://netbio.bgu.ac.il/myproteinnet. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  6. SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo.

    Science.gov (United States)

    Paul, Jonathan D; Coulombe, Kareen L K; Toth, Peter T; Zhang, Yanmin; Marsboom, Glenn; Bindokas, Vytas P; Smith, David W; Murry, Charles E; Rehman, Jalees

    2013-11-01

    Successful implantation and long-term survival of engineered tissue grafts hinges on adequate vascularization of the implant. Endothelial cells are essential for patterning vascular structures, but they require supportive mural cells such as pericytes/mesenchymal stem cells (MSCs) to generate stable, functional blood vessels. While there is evidence that the angiogenic effect of MSCs is mediated via the secretion of paracrine signals, the identity of these signals is unknown. By utilizing two functionally distinct human MSC clones, we found that so-called "pericytic" MSCs secrete the pro-angiogenic vascular guidance molecule SLIT3, which guides vascular development by directing ROBO4-positive endothelial cells to form networks in engineered tissue. In contrast, "non-pericytic" MSCs exhibit reduced activation of the SLIT3/ROBO4 pathway and do not support vascular networks. Using live cell imaging of organizing 3D vascular networks, we show that siRNA knockdown of SLIT3 in MSCs leads to disorganized clustering of ECs. Knockdown of its receptor ROBO4 in ECs abolishes the generation of functional human blood vessels in an in vivo xenogenic implant. These data suggest that the SLIT3/ROBO4 pathway is required for MSC-guided vascularization in engineered tissues. Heterogeneity of SLIT3 expression may underlie the variable clinical success of MSCs for tissue repair applications. © 2013. Published by Elsevier Ltd. All rights reserved.

  7. A facile one-step strategy for development of a double network fibrous scaffold for nerve tissue engineering.

    Science.gov (United States)

    Golafshan, Nasim; Gharibi, Hamidreza; Kharaziha, Mahshid; Fathi, Mohammadhossein

    2017-04-28

    The aim of this study was to develop a novel double network scaffold composed of polycaprolactone fumarate (PCLF) and eggshell membrane (ESM) (ESM:PCLF) by using the vacuum infiltration method. Compared to ESM, the mechanical properties of double network scaffold were significantly improved, depending on the solvents applied for double network scaffold formation; acetic acid and dichloromethane. Noticeably, the toughness and strength of double network scaffold prepared using acetic acid were significantly improved compared to ESM (26.6 and 25 times, respectively) attributed to the existence of hydrophilic functional groups in acetic acid which made ESM flexible to absorb further PCLF solution. To assess the effect of double network formation on the biological behavior of ESM, the attachment, proliferation and spreading of PC12 cells cultured on the ESM:PCLF scaffolds were evaluated. Results revealed that the number of cells attached on double network ESM:PCLF scaffold were nearly similar to ESM and significantly higher than that of on the tissue culture plate (2.6 times) and PCLF film (1.7 times). It is envisioned that the offered ESM:PCLF double network scaffold might have great potential to develop the constructs for nerve regeneration.

  8. Computational analysis of cartilage implants based on an interpenetrated polymer network for tissue repairing.

    Science.gov (United States)

    Manzano, Sara; Poveda-Reyes, Sara; Ferrer, Gloria Gallego; Ochoa, Ignacio; Hamdy Doweidar, Mohamed

    2014-10-01

    Interpenetrated polymer networks (IPNs), composed by two independent polymeric networks that spatially interpenetrate, are considered as valuable systems to control permeability and mechanical properties of hydrogels for biomedical applications. Specifically, poly(ethyl acrylate) (PEA)-poly(2-hydroxyethyl acrylate) (PHEA) IPNs have been explored as good hydrogels for mimicking articular cartilage. These lattices are proposed as matrix implants in cartilage damaged areas to avoid the discontinuity in flow uptake preventing its deterioration. The permeability of these implants is a key parameter that influences their success, by affecting oxygen and nutrient transport and removing cellular waste products to healthy cartilage. Experimental try-and-error approaches are mostly used to optimize the composition of such structures. However, computational simulation may offer a more exhaustive tool to test and screen out biomaterials mimicking cartilage, avoiding expensive and time-consuming experimental tests. An accurate and efficient prediction of material's permeability and internal directionality and magnitude of the fluid flow could be highly useful when optimizing biomaterials design processes. Here we present a 3D computational model based on Sussman-Bathe hyperelastic material behaviour. A fluid structure analysis is performed with ADINA software, considering these materials as two phases composites where the solid part is saturated by the fluid. The model is able to simulate the behaviour of three non-biodegradable hydrogel compositions, where percentages of PEA and PHEA are varied. Specifically, the aim of this study is (i) to verify the validity of the Sussman-Bathe material model to simulate the response of the PEA-PHEA biomaterials; (ii) to predict the fluid flux and the permeability of the proposed IPN hydrogels and (iii) to study the material domains where the passage of nutrients and cellular waste products is reduced leading to an inadequate flux

  9. Effect of vascular network and nanoparticles on heat transfer and intracellular ice formation in tumor tissues during cryosurgery.

    Science.gov (United States)

    Yu, Qianfeng; Yi, Jungru; Zhao, Gang; Zhang, Yuntian

    2014-01-01

    Cryosurgery is a physical therapy of tumor treatment which is welcome in clinics for its minimally invasive advantage. However, the high recurrence rate makes the conventional cryosurgery unsatisfactory, which needs adjuvant treatment such as introduction of nanoparticles. This study is to examine the effects of vascular network and MgO nanoparticles on heat transfer and intracellular ice formation in tumor tissues during cryosurgery. We developed a multi-scale model to study the efficiency of cryosurgery, including the macro-level (mass tumor tissue) heat transfer and the micro-level (tumor cells) probability of intracellular ice formation (PIF). The model is used to examine the effects of fractal vascular network (VN) and nanoparticles with different concentration on heat transfer and PIF during cryosurgery in the breast cancer tissue (MCF-7 cells). The nucleation rate kinetic parameter and the thermodynamic parameter of MCF-7 cells are determined by nonlinear curve-fitting the published experimental data, and then the probability of intracellular ice formation of the picked points in the tumor tissue are determined using the classic model for intracellular ice nucleation with the simulated thermal profiles at those points during cryosurgery. The introduction of nanoparticles have significantly enhanced the heat transfer in the mass tumor tissue and increased the PIF of tumor cells, indicating the nanocryosurgery is more efficient than conventional cryosurgery.

  10. Thomas K. Jeffers: pioneer of coccidiosis research.

    Science.gov (United States)

    Chapman, H D

    2012-01-01

    Thomas K. Jeffers has made many significant contributions to our understanding of the biology of the parasite Eimeria, the cause of coccidiosis in poultry. His work has had direct practical application for the control of this widespread disease. Topics discussed include Jeffers' pioneering work concerned with genetics of the host response to infection, the nature of biological and immunological intraspecific variation, drug resistance and discovery, field surveys of resistance, and his most recognized achievement-the demonstration that the lifecycle of coccidia may be altered by artificial selection. Parasites so modified are attenuated but retain their immunogenicity, a discovery that has led to the development of live vaccines that are inherently non-pathogenic. This article provides a brief biography and describes the contributions that Jeffers has made to our knowledge of coccidiosis.

  11. FRIEDMAN Thomas, La terre est plate

    OpenAIRE

    Kociemba, Valérie

    2008-01-01

    « L’Église dit que la terre est plate, mais j’ai vu l’ombre sur la lune et j’ai plus foi en l’ombre qu’en l’église. » (Ferdinand Magellan) Bien des siècles plus tard, Thomas Friedman réitère l’affirmation en titre de son dernier ouvrage : La terre est plate, Une brève histoire du xxie siècle. À quelle Église appartient donc ce brillant éditorialiste du « New York Times » ? À l’Église de la toute puissance des nouvelles technologies de l’information, et il n’en fait pas mystère puisqu’il décla...

  12. [Thomas Schwencke and Wolfgang Amadeus Mozart].

    Science.gov (United States)

    Hillen, Harry F P

    2010-01-01

    Thomas Schwencke (1694-1767) was Professor of Anatomy and Surgery and Lecturer in Obstetrics at the Surgical School in The Hague, the Netherlands. In 1743 he published the very first textbook on haematology. Furthermore, he described his observations on the variolation of smallpox, and published the design of a new obstetric instrument. Schwencke was physician of the city of The Hague and also physician at the court of the princes van Nassau-Weilburg. In 1765 Princess Caroline of Nassau-Weilburg invited the young Wolfgang Amadeus Mozart to perform concerts. During his Dutch tour the young Mozart fell seriously ill, probably from typhoid fever. At the request of the court Mozart was seen for a second opinion and thereafter successfully treated by Schwencke. Mozart could continue his concert tour and Schwencke's reputation as Mozart's physician was established.

  13. Contributions of Thomas Jefferson to American medicine.

    Science.gov (United States)

    Cohn, L H

    1979-08-01

    Thomas Jefferson, the third president of the United States and author of the Declaration of Independence, had a consuming interest in all fields of education and science, including the practice of medicine and public health. He actively developed medical education, supported measures for public health, and encouraged scientific research supported by the government without policy intervention. Although a close friend of eminent physicians, his rationalism and scientific method placed him ahead of many practitioners of his time. He disparaged medical quackery but actively supported therapies such as vaccination that were based on research and careful observation. The School of Medicine at the University of Virginia was Jefferson's concrete contribution to the advancement of medical education in the United States and epitomized his preoccupation with medicine and science as important cornerstones of a healthy American nation.

  14. Thomas C. Schelling: la paradoja de un economista errante

    National Research Council Canada - National Science Library

    Salazar, Boris

    2007-01-01

    ..., puntos focales, heuristica, teoria de juegos, dinamica social, circuitos neurales; JEL: B31, B41, D83] Thomas C. Schelling: the Paradox of a Wandering Economist This article explains two enigmas related to the scientific career of Thomas C. Schelling, Nobel Price in Economics 2005: How to explain his capacity to always produce new ideas? Why h...

  15. Praost Thomas Vaga 70 / Juhan Simonson ; foto: Juhan Simonson

    Index Scriptorium Estoniae

    Simonson, Juhan, 1933-2012

    2008-01-01

    8. märtsil 70 aastaseks saavast üle 20 aasta kirikuõpetajana New Jerseys ja New Yorgis teeninud praost Thomas Vagast. President Toomas Hendrik Ilves annetas iseseisvuspäeva puhul Thomas Vagale kui eestluse hoidjale Ameerika Ühendriikides ja kirikuelu edendajale Valgetähe IV klassi teenetemärgi

  16. Bathymetry (2011) of the St. Thomas East End Reserve

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a LiDAR (Light Detection & Ranging) 0.3x0.3 meter resolution depth surface for the St. Thomas East End Reserve (STEER), St. Thomas in the...

  17. Orthophoto Mosaic (2012) of the St. Thomas East End Reserve

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 0.3x0.3 meter imagery mosaic of the St. Thomas East End Reserve (STEER), St. Thomas in the U.S. Virgin Islands was created by the National Oceanic and...

  18. A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology

    OpenAIRE

    Bordbar, Aarash; Feist, Adam M; Usaite-Black, Renata; Woodcock, Joseph; Palsson, Bernhard O; Famili, Iman

    2011-01-01

    Abstract Background Genome-scale metabolic reconstructions provide a biologically meaningful mechanistic basis for the genotype-phenotype relationship. The global human metabolic network, termed Recon 1, has recently been reconstructed allowing the systems analysis of human metabolic physiology and pathology. Utilizing high-throughput data, Recon 1 has recently been tailored to different cells and tissues, including the liver, kidney, brain, and alveolar macrophage. These models have shown ut...

  19. System model network for adipose tissue signatures related to weight changes in response to calorie restriction and subsequent weight maintenance.

    Science.gov (United States)

    Montastier, Emilie; Villa-Vialaneix, Nathalie; Caspar-Bauguil, Sylvie; Hlavaty, Petr; Tvrzicka, Eva; Gonzalez, Ignacio; Saris, Wim H M; Langin, Dominique; Kunesova, Marie; Viguerie, Nathalie

    2015-01-01

    Nutrigenomics investigates relationships between nutrients and all genome-encoded molecular entities. This holistic approach requires systems biology to scrutinize the effects of diet on tissue biology. To decipher the adipose tissue (AT) response to diet induced weight changes we focused on key molecular (lipids and transcripts) AT species during a longitudinal dietary intervention. To obtain a systems model, a network approach was used to combine all sets of variables (bio-clinical, fatty acids and mRNA levels) and get an overview of their interactions. AT fatty acids and mRNA levels were quantified in 135 obese women at baseline, after an 8-week low calorie diet (LCD) and after 6 months of ad libitum weight maintenance diet (WMD). After LCD, individuals were stratified a posteriori according to weight change during WMD. A 3 steps approach was used to infer a global model involving the 3 sets of variables. It consisted in inferring intra-omic networks with sparse partial correlations and inter-omic networks with regularized canonical correlation analysis and finally combining the obtained omic-specific network in a single global model. The resulting networks were analyzed using node clustering, systematic important node extraction and cluster comparisons. Overall, AT showed both constant and phase-specific biological signatures in response to dietary intervention. AT from women regaining weight displayed growth factors, angiogenesis and proliferation signaling signatures, suggesting unfavorable tissue hyperplasia. By contrast, after LCD a strong positive relationship between AT myristoleic acid (a fatty acid with low AT level) content and de novo lipogenesis mRNAs was found. This relationship was also observed, after WMD, in the group of women that continued to lose weight. This original system biology approach provides novel insight in the AT response to weight control by highlighting the central role of myristoleic acid that may account for the beneficial

  20. System model network for adipose tissue signatures related to weight changes in response to calorie restriction and subsequent weight maintenance.

    Directory of Open Access Journals (Sweden)

    Emilie Montastier

    2015-01-01

    Full Text Available Nutrigenomics investigates relationships between nutrients and all genome-encoded molecular entities. This holistic approach requires systems biology to scrutinize the effects of diet on tissue biology. To decipher the adipose tissue (AT response to diet induced weight changes we focused on key molecular (lipids and transcripts AT species during a longitudinal dietary intervention. To obtain a systems model, a network approach was used to combine all sets of variables (bio-clinical, fatty acids and mRNA levels and get an overview of their interactions. AT fatty acids and mRNA levels were quantified in 135 obese women at baseline, after an 8-week low calorie diet (LCD and after 6 months of ad libitum weight maintenance diet (WMD. After LCD, individuals were stratified a posteriori according to weight change during WMD. A 3 steps approach was used to infer a global model involving the 3 sets of variables. It consisted in inferring intra-omic networks with sparse partial correlations and inter-omic networks with regularized canonical correlation analysis and finally combining the obtained omic-specific network in a single global model. The resulting networks were analyzed using node clustering, systematic important node extraction and cluster comparisons. Overall, AT showed both constant and phase-specific biological signatures in response to dietary intervention. AT from women regaining weight displayed growth factors, angiogenesis and proliferation signaling signatures, suggesting unfavorable tissue hyperplasia. By contrast, after LCD a strong positive relationship between AT myristoleic acid (a fatty acid with low AT level content and de novo lipogenesis mRNAs was found. This relationship was also observed, after WMD, in the group of women that continued to lose weight. This original system biology approach provides novel insight in the AT response to weight control by highlighting the central role of myristoleic acid that may account for the

  1. System Model Network for Adipose Tissue Signatures Related to Weight Changes in Response to Calorie Restriction and Subsequent Weight Maintenance

    Science.gov (United States)

    Montastier, Emilie; Villa-Vialaneix, Nathalie; Caspar-Bauguil, Sylvie; Hlavaty, Petr; Tvrzicka, Eva; Gonzalez, Ignacio; Saris, Wim H. M.; Langin, Dominique; Kunesova, Marie; Viguerie, Nathalie

    2015-01-01

    Nutrigenomics investigates relationships between nutrients and all genome-encoded molecular entities. This holistic approach requires systems biology to scrutinize the effects of diet on tissue biology. To decipher the adipose tissue (AT) response to diet induced weight changes we focused on key molecular (lipids and transcripts) AT species during a longitudinal dietary intervention. To obtain a systems model, a network approach was used to combine all sets of variables (bio-clinical, fatty acids and mRNA levels) and get an overview of their interactions. AT fatty acids and mRNA levels were quantified in 135 obese women at baseline, after an 8-week low calorie diet (LCD) and after 6 months of ad libitum weight maintenance diet (WMD). After LCD, individuals were stratified a posteriori according to weight change during WMD. A 3 steps approach was used to infer a global model involving the 3 sets of variables. It consisted in inferring intra-omic networks with sparse partial correlations and inter-omic networks with regularized canonical correlation analysis and finally combining the obtained omic-specific network in a single global model. The resulting networks were analyzed using node clustering, systematic important node extraction and cluster comparisons. Overall, AT showed both constant and phase-specific biological signatures in response to dietary intervention. AT from women regaining weight displayed growth factors, angiogenesis and proliferation signaling signatures, suggesting unfavorable tissue hyperplasia. By contrast, after LCD a strong positive relationship between AT myristoleic acid (a fatty acid with low AT level) content and de novo lipogenesis mRNAs was found. This relationship was also observed, after WMD, in the group of women that continued to lose weight. This original system biology approach provides novel insight in the AT response to weight control by highlighting the central role of myristoleic acid that may account for the beneficial

  2. Reconstruction of enhancer-target networks in 935 samples of human primary cells, tissues and cell lines.

    Science.gov (United States)

    Cao, Qin; Anyansi, Christine; Hu, Xihao; Xu, Liangliang; Xiong, Lei; Tang, Wenshu; Mok, Myth T S; Cheng, Chao; Fan, Xiaodan; Gerstein, Mark; Cheng, Alfred S L; Yip, Kevin Y

    2017-10-01

    We propose a new method for determining the target genes of transcriptional enhancers in specific cells and tissues. It combines global trends across many samples and sample-specific information, and considers the joint effect of multiple enhancers. Our method outperforms existing methods when predicting the target genes of enhancers in unseen samples, as evaluated by independent experimental data. Requiring few types of input data, we are able to apply our method to reconstruct the enhancer-target networks in 935 samples of human primary cells, tissues and cell lines, which constitute by far the largest set of enhancer-target networks. The similarity of these networks from different samples closely follows their cell and tissue lineages. We discover three major co-regulation modes of enhancers and find defense-related genes often simultaneously regulated by multiple enhancers bound by different transcription factors. We also identify differentially methylated enhancers in hepatocellular carcinoma (HCC) and experimentally confirm their altered regulation of HCC-related genes.

  3. Interpenetrating networks based on gelatin methacrylamide and PEG formed using concurrent thiol click chemistries for hydrogel tissue engineering scaffolds.

    Science.gov (United States)

    Daniele, Michael A; Adams, André A; Naciri, Jawad; North, Stella H; Ligler, Frances S

    2014-02-01

    The integration of biological extracellular matrix (ECM) components and synthetic materials is a promising pathway to fabricate the next generation of hydrogel-based tissue scaffolds that more accurately emulate the microscale heterogeneity of natural ECM. We report the development of a bio/synthetic interpenetrating network (BioSINx), containing gelatin methacrylamide (GelMA) polymerized within a poly(ethylene glycol) (PEG) framework to form a mechanically robust network capable of supporting both internal cell encapsulation and surface cell adherence. The covalently crosslinked PEG network was formed by thiol-yne coupling, while the bioactive GelMA was integrated using a concurrent thiol-ene coupling reaction. The physical properties (i.e. swelling, modulus) of BioSINx were compared to both PEG networks with physically-incorporated gelatin (BioSINP) and homogenous hydrogels. BioSINx displayed superior physical properties and significantly lower gelatin dissolution. These benefits led to enhanced cytocompatibility for both cell adhesion and encapsulation; furthermore, the increased physical strength provided for the generation of a micro-engineered tissue scaffold. Endothelial cells showed extensive cytoplasmic spreading and the formation of cellular adhesion sites when cultured onto BioSINx; moreover, both encapsulated and adherent cells showed sustained viability and proliferation. Copyright © 2013 Elsevier Ltd. All rights reserved.

  4. Neural network-based brain tissue segmentation in MR images using extracted features from intraframe coding in H.264

    Science.gov (United States)

    Jafari, Mehdi; Kasaei, Shohreh

    2012-01-01

    Automatic brain tissue segmentation is a crucial task in diagnosis and treatment of medical images. This paper presents a new algorithm to segment different brain tissues, such as white matter (WM), gray matter (GM), cerebral spinal fluid (CSF), background (BKG), and tumor tissues. The proposed technique uses the modified intraframe coding yielded from H.264/(AVC), for feature extraction. Extracted features are then imposed to an artificial back propagation neural network (BPN) classifier to assign each block to its appropriate class. Since the newest coding standard, H.264/AVC, has the highest compression ratio, it decreases the dimension of extracted features and thus yields to a more accurate classifier with low computational complexity. The performance of the BPN classifier is evaluated using the classification accuracy and computational complexity terms. The results show that the proposed technique is more robust and effective with low computational complexity compared to other recent works.

  5. Cartilage oligomeric matrix protein (COMP)-mediated cell differentiation to proteolysis mechanism networks from human normal adjacent tissues to lung adenocarcinoma.

    Science.gov (United States)

    Wang, Lin; Huang, Juxiang; Jiang, Minghu; Diao, Haizhen; Zhou, Huilei; Li, Xiaohe; Chen, Qingchun; Jiang, Zhenfu; Feng, Haitao; Wolfl, Stefan

    2013-01-01

    To understand cartilage oligomeric matrix protein (COMP) mechanism network from human normal adjacent tissues to lung adenocarcinoma. COMP complete different activated (all no positive correlation, Pearson CC lung adenocarcinoma compared with lower human normal adjacent tissues from the corresponding COMP-stimulated (≥0.25) or inhibited (Pearson CC ≤ -0.25) overlapping molecules of Pearson correlation coefficient (CC) and GRNInfer, respectively. COMP complete different activated and inhibited (all no positive correlation, Pearson CC lung adenocarcinoma and lower human normal adjacent tissues were constructed by integration of Pearson CC, GRNInfer and GO. As visualized by integration of GO, KEGG, GenMAPP, BioCarta and Disease, we deduced COMP complete different activated and inhibited network in higher lung adenocarcinoma and lower human normal adjacent tissues. As visualized by GO, KEGG, GenMAPP, BioCarta and disease database integration, we proposed mainly that the mechanism and function of COMP complete different activated network in higher lung adenocarcinoma was involved in COMP activation with matrix-localized insulin-like factor coupling carboxypeptidase to metallopeptidase-induced proteolysis, whereas the corresponding inhibited network in lower human normal adjacent tissues participated in COMP inhibition with nucleus-localized vasculogenesis, B and T cell differentiation and neural endocrine factors coupling pyrophosphatase-mediated proteolysis. However, COMP complete different inhibited network in higher lung adenocarcinoma included COMP inhibition with nucleus-localized chromatin maintenance, licensing and assembly factors coupling phosphatase-inhibitor to cytokinesis regulators-mediated cell differentiation, whereas the corresponding activated network in lower human normal adjacent tissues contained COMP activation with cytolplasm-localized translation elongation factor coupling fucosyltransferase to ubiquitin-protein ligase-induced cell

  6. Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes.

    Directory of Open Access Journals (Sweden)

    Josine L Min

    Full Text Available Metabolic Syndrome (MetS is highly prevalent and has considerable public health impact, but its underlying genetic factors remain elusive. To identify gene networks involved in MetS, we conducted whole-genome expression and genotype profiling on abdominal (ABD and gluteal (GLU adipose tissue, and whole blood (WB, from 29 MetS cases and 44 controls. Co-expression network analysis for each tissue independently identified nine, six, and zero MetS-associated modules of coexpressed genes in ABD, GLU, and WB, respectively. Of 8,992 probesets expressed in ABD or GLU, 685 (7.6% were expressed in ABD and 51 (0.6% in GLU only. Differential eigengene network analysis of 8,256 shared probesets detected 22 shared modules with high preservation across adipose depots (D(ABD-GLU = 0.89, seven of which were associated with MetS (FDR P100,000 individuals; rs10282458, affecting expression of RARRES2 (encoding chemerin, was associated with body mass index (BMI (P = 6.0×10(-4; and rs2395185, affecting inter-depot differences of HLA-DRB1 expression, was associated with high-density lipoprotein (P = 8.7×10(-4 and BMI-adjusted waist-to-hip ratio (P = 2.4×10(-4. Since many genes and their interactions influence complex traits such as MetS, integrated analysis of genotypes and coexpression networks across multiple tissues relevant to clinical traits is an efficient strategy to identify novel associations.

  7. Implantable Body Sensor Network MAC Protocols Using Wake-up Radio – Evaluation in Animal Tissue

    NARCIS (Netherlands)

    Karuppiah Ramachandran, Vignesh Raja; van der Zwaag, B.J.; Meratnia, Nirvana; Havinga, Paul J.M.

    Applications of implantable sensor networks in the health-care industry have increased tremendously over the last decade. There are different types of medium access control (MAC) protocols that are designed for implantable body sensor networks, using different physical layer technologies such as

  8. Comparison of Metabolic Network between Muscle and Intramuscular Adipose Tissues in Hanwoo Beef Cattle Using a Systems Biology Approach

    Directory of Open Access Journals (Sweden)

    Hyun-Jeong Lee

    2014-01-01

    Full Text Available The interrelationship between muscle and adipose tissues plays a major role in determining the quality of carcass traits. The objective of this study was to compare metabolic differences between muscle and intramuscular adipose (IMA tissues in the longissimus dorsi (LD of Hanwoo (Bos taurus coreanae using the RNA-seq technology and a systems biology approach. The LD sections between the 6th and 7th ribs were removed from nine (each of three cows, steers, and bulls Hanwoo beef cattle (carcass weight of 430.2±40.66 kg immediately after slaughter. The total mRNA from muscle, IMA, and subcutaneous adipose and omental adipose tissues were isolated and sequenced. The reads that passed quality control were mapped onto the bovine reference genome (build bosTau6, and differentially expressed genes across tissues were identified. The KEGG pathway enrichment tests revealed the opposite direction of metabolic regulation between muscle and IMA. Metabolic gene network analysis clearly indicated that oxidative metabolism was upregulated in muscle and downregulated in IMA. Interestingly, pathways for regulating cell adhesion, structure, and integrity and chemokine signaling pathway were upregulated in IMA and downregulated in muscle. It is thus inferred that IMA may play an important role in the regulation of development and structure of the LD tissues and muscle/adipose communication.

  9. Comparison of Metabolic Network between Muscle and Intramuscular Adipose Tissues in Hanwoo Beef Cattle Using a Systems Biology Approach.

    Science.gov (United States)

    Lee, Hyun-Jeong; Park, Hye-Sun; Kim, Woonsu; Yoon, Duhak; Seo, Seongwon

    2014-01-01

    The interrelationship between muscle and adipose tissues plays a major role in determining the quality of carcass traits. The objective of this study was to compare metabolic differences between muscle and intramuscular adipose (IMA) tissues in the longissimus dorsi (LD) of Hanwoo (Bos taurus coreanae) using the RNA-seq technology and a systems biology approach. The LD sections between the 6th and 7th ribs were removed from nine (each of three cows, steers, and bulls) Hanwoo beef cattle (carcass weight of 430.2 ± 40.66 kg) immediately after slaughter. The total mRNA from muscle, IMA, and subcutaneous adipose and omental adipose tissues were isolated and sequenced. The reads that passed quality control were mapped onto the bovine reference genome (build bosTau6), and differentially expressed genes across tissues were identified. The KEGG pathway enrichment tests revealed the opposite direction of metabolic regulation between muscle and IMA. Metabolic gene network analysis clearly indicated that oxidative metabolism was upregulated in muscle and downregulated in IMA. Interestingly, pathways for regulating cell adhesion, structure, and integrity and chemokine signaling pathway were upregulated in IMA and downregulated in muscle. It is thus inferred that IMA may play an important role in the regulation of development and structure of the LD tissues and muscle/adipose communication.

  10. Donaldson-Thomas theory for Calabi-Yau 4-folds

    OpenAIRE

    Cao, Yalong; Leung, Naichung Conan

    2014-01-01

    Let $X$ be a compact complex Calabi-Yau 4-fold. Under certain assumptions, we define Donaldson-Thomas type deformation invariants ($DT_{4}$ invariants) by studying moduli spaces of solutions to the Donaldson-Thomas equations on $X$. We also study sheaves counting problems on local Calabi-Yau 4-folds. We relate $DT_{4}$ invariants of $K_{Y}$ to the Donaldson-Thomas invariants of the associated Fano 3-fold $Y$. When the Calabi-Yau 4-fold is toric, we adapt the virtual localization formula to de...

  11. Thomas Piketty’s capitalism revisited

    Directory of Open Access Journals (Sweden)

    Milovanović Milić

    2015-01-01

    Full Text Available Thomas Piketty’s international best selling Capital in the Twenty-First Century lays out his theory of a long-run rise in income inequality under capitalism. It is written as a manifesto urging reintegration of social sciences. A number of reviewers judged it on ideological grounds, labeling it either as a revolution in economic thinking, or dismissing it offhandedly. Piketty’s theory of rising inequality is based on the two Fundamental Laws of Capitalism, developed after the Solow growth model. However, this model is inconsistent with Piketty’s own characterization of modern capitalism. Moreover, his sole justification for the constant discrepancy between rate of return and rate of income growth (r > g is based on the high elasticity of substitution between capital and labor. However, that is just one factor that can have an influence on factor income shares. By failing to offer a consistent theory of rising inequality, his piece can hardly be considered as a useful founding stone for a new social science.

  12. KONSTRUKSI TEORI PARADIGMA THOMAS S. KUHN

    Directory of Open Access Journals (Sweden)

    Nurkhalis Nurkhalis

    2012-02-01

    Full Text Available Thomas Kuhn memberikan gambaran bahwa kebenaran sains akan ditemukan berkali-kali ataupun berganti-ganti bentuk ilmiahnya walaupun dari satu objek yang sama. Formulasi teori paradigma yang mencetuskan bahwa sebuah kebenaran sains (legatimed truth identik dalam target teleologis yang didasari pada detection dikenal sebagai final cause (end. Kebenaran sains bukan continuous (lanjutan, improvisasi, evolusi atau kumulatif, melainkan terjadi paradigm shift (pergeseran paradigma atau disebut juga dengan revolusi. Paradigma melalui shift moving (pergerakan pergeseran dipahami sama dengan gestalt switch (perpindahan secara keseluruhan atau tidak sama sekali. Di dalam gestalt switch yang diungkapkan adalah verifikasi terjadi sekaligus atau tidak sama sekali (all at once or not at all. Konsep paradigm shifts membuka kesadaran bersama bahwa para pengkaji sains tidak akan mungkin bekerja dalam suatu suasana objektivitas yang mapan. Paradigma men-design kerangka world view (pandangan dunia atau perspective (cara pandang untuk lebih important, legitimate, and reasonable. Hal ini membuat sebuah detection (target teleologis tidak akan terevolusi atau tereleminir karena kemampuan eksperimentalnya mengakomodir counterinstances (ketahanan berkompetisi teori. Paradigma yang bertahan merupakan winnowing (keunggulan baru dari sebuah discovery, supertitian (temuan besar atau novelty (terbaharukan. Paradigma bertahan akan tumbuh menguasai normal science selama belum eksisnya anomaly (ketimpangan. Paradigma baru memiliki kriteria neater (rapi, more suitable (lebih cocok, simpler (sederhana, or more elegant (lebih elegan. Paradigma akan terusbertransformatif dengan paradigma baru karena sistem bekerja paradigma mengalihkan padigma menuju revolusi ilmiah di mana revolusi ilmiah dengan perubahan fundamental akan meresap dalam metode dan pemahaman.

  13. Localized Donaldson-Thomas theory of surfaces

    DEFF Research Database (Denmark)

    Gholampour, Amin; Sheshmani, Artan; Yau, Shing-Tung

    2017-01-01

    of the fixed locus of the moduli space with the moduli space of torsion free sheaves and the nested Hilbert schemes on S. We define the localized Donaldson-Thomas invariants of  by virtual localization in the case that  twisted by the anti-canonical bundle of S admits a nonzero global section. When pg(S)>0......Let S be a projective simply connected complex surface and  be a line bundle on S. We study the moduli space of stable compactly supported 2-dimensional sheaves on the total spaces of . The moduli space admits a ℂ∗-action induced by scaling the fibers of . We identify certain components......, in combination with Mochizuki's formulas, we are able to express the localized DT invariants in terms of the invariants of the nested Hilbert schemes defined by the authors in [GSY17a], the Seiberg-Witten invariants of S, and the integrals over the products of Hilbert schemes of points on S. When...

  14. Thomas Edison’s Poetry Machine

    Directory of Open Access Journals (Sweden)

    Matthew Rubery

    2014-04-01

    Full Text Available The tradition of spoken-word recording began with Thomas Edison’s invention of the phonograph. Hence, this article makes the case that 1878 is a more important year to the history of literature than has yet been recognized for its experiments with verse and sound-recording technology. Although the tinfoil phonograph’s first decade has been well documented by media historians, literary critics have singled out 1888 as the noteworthy year since that is when Edison’s improved phonograph made it possible to record prominent figures including Alfred Tennyson and Robert Browning. Taking Edison’s original tinfoil phonograph as an alternative starting point reveals how the 1878 phonograph demonstrations, despite technological limitations, undertook acoustic experiments that enabled audiences to discern new forms of meaning, pleasure, and pathos in even the most well-known material. The recordings considered here include ‘Mary Had a Little Lamb’ as well as scripts by Tennyson, Caroline Norton, Edgar Allan Poe, Shakespeare, and others. Such recitals illustrate the extent to which Edison’s talking machine influenced the reception of texts while at the same time giving rise to performances unheard of in previous cultures.

  15. Thomas Walter Bannerman Kibble (1932 - 2016)

    CERN Multimedia

    2016-01-01

    Tom Kibble, an internationally-renowned theoretical physicist, passed away on Thursday 2 June.   Tom Kibble in the CMS cavern during a visit to CERN in 2014. (Photo: CMS/CERN) Professor Thomas Walter Bannerman Kibble passed away unexpectedly on 2 June at the age of 83. He was senior research investigator at the Blackett Laboratory and Emeritus Professor of Theoretical Physics at Imperial College, London. He made seminal contributions to our current understanding of symmetries and symmetry breaking in the Standard Model of particle physics. He was among those who, in 1964, proposed the mechanism of spontaneous symmetry breaking in gauge theories, together with G. Guralnik and C. Hagen in the autumn of that year, following the papers by R. Brout and F. Englert and by P. Higgs. When this new understanding was incorporated into a model proposed by S. Glashow in 1961, it led to the first formulations of the Standard Model by S. Weinberg and A. Salam. Kibble deepened our under...

  16. Health Care Ergonomics: Contributions of Thomas Waters.

    Science.gov (United States)

    Poole Wilson, Tiffany; Davis, Kermit G

    2016-08-01

    The aim of this study was to assess the contributions of Thomas Waters's work in the field of health care ergonomics and beyond. Waters's research of safe patient handling with a focus on reducing musculoskeletal disorders (MSDs) in health care workers contributed to current studies and prevention strategies. He worked with several groups to share his research and assist in developing safe patient handling guidelines and curriculum for nursing students and health care workers. The citations of articles that were published by Waters in health care ergonomics were evaluated for quality and themes of conclusions. Quality was assessed using the Mixed Methods Appraisal Tool and centrality to original research rating. Themes were documented by the type of population the citing articles were investigating. In total, 266 articles that referenced the top seven cited articles were evaluated. More than 95% of them were rated either medium or high quality. The important themes of these citing articles were as follows: (a) Safe patient handling is effective in reducing MSDs in health care workers. (b) Shift work has negative impact on nurses. (c) There is no safe way to manually lift a patient. (d) Nurse curriculums should contain safe patient handling. The research of Waters has contributed significantly to the health care ergonomics and beyond. His work, in combination with other pioneers in the field, has generated multiple initiatives, such as a standard safe patient-handling curriculum and safe patient-handling programs. © 2016, Human Factors and Ergonomics Society.

  17. Thomas Wolsey on stage and screen

    Directory of Open Access Journals (Sweden)

    Patrick Hornbeck

    2016-08-01

    Full Text Available Cardinal Thomas Wolsey, lord chancellor of England from 1515 to 1529, has played no small part in the many literary, historical and dramatic retellings of the reign of King Henry VIII. This article presents the first extended analysis of the way in which Wolsey has been represented by playwrights and, later, film and television writers during the years from his death in 1530 through the present. The article demonstrates that by the middle of the 16th century, two competing narratives about Wolsey had become entrenched historiographically, and nearly all subsequent accounts borrow substantially from the narratives of either Edward Hall (1550 or George Cavendish (1554–1558. How successive playwrights and screenwriters balanced the cardinal’s two archetypal personae has often depended, in no small part, on the concerns of their own day. In the 21st century, readings of the cardinal as crafty rather than callous, unlucky rather than unprincipled, have become more common, and with them have come more sympathetic portrayals of a traditional Tudor villain.

  18. Thomas Wolsey on stage and screen

    Directory of Open Access Journals (Sweden)

    Patrick Hornbeck

    2016-05-01

    Full Text Available Cardinal Thomas Wolsey, lord chancellor of England from 1515 to 1529, has played no small part in the many literary, historical and dramatic retellings of the reign of King Henry VIII. This article presents the first extended analysis of the way in which Wolsey has been represented by playwrights and, later, film and television writers during the years from his death in 1530 through the present. The article demonstrates that by the middle of the 16th century, two competing narratives about Wolsey had become entrenched historiographically, and nearly all subsequent accounts borrow substantially from the narratives of either Edward Hall (1550 or George Cavendish (1554–1558. How successive playwrights and screenwriters balanced the cardinal’s two archetypal personae has often depended, in no small part, on the concerns of their own day. In the 21st century, readings of the cardinal as crafty rather than callous, unlucky rather than unprincipled, have become more common, and with them have come more sympathetic portrayals of a traditional Tudor villain.

  19. Thomas Trotter's 'Essay on Drunkenness' appraised.

    Science.gov (United States)

    Edwards, Griffith

    2012-09-01

    In 1804 Thomas Trotter, a recently retired Physician to the Fleet, published his 'Essay on Drunkenness'. This was the first ever book-length consideration of the phenomenon of alcohol dependence and its treatment. The aim of this paper is to explore the impact of that treatise on the evolution of relevant ideas over the years that have followed. A factual analysis of the content of the Essay is the starting-point, followed by an examination of sequential published appraisals on the significance, or lack of significance, of this work. To the modern reader, Trotter is likely to be seen as prescient, with his assertion that 'the habit of drunkenness is a disease of the mind', setting the scene for two centuries of debate. The literature, however, seems to suggest that Trotter did not, in fact, achieve much impact either on professional opinion or on the emergent temperance movement. It was Benjamin Rush's 1785 pamphlet on 'Ardent Spirits' which achieved iconic status. Rush and Trotter, although in some ways overlapping in their ideas, differed in other respects. © 2012 The Author. Addiction © 2012 Society for the Study of Addiction.

  20. Cyclic deformation-induced solute transport in tissue scaffolds with computer designed, interconnected, pore networks: experiments and simulations.

    Science.gov (United States)

    Den Buijs, Jorn Op; Dragomir-Daescu, Dan; Ritman, Erik L

    2009-08-01

    Nutrient supply and waste removal in porous tissue engineering scaffolds decrease from the periphery to the center, leading to limited depth of ingrowth of new tissue into the scaffold. However, as many tissues experience cyclic physiological strains, this may provide a mechanism to enhance solute transport in vivo before vascularization of the scaffold. The hypothesis of this study was that pore cross-sectional geometry and interconnectivity are of major importance for the effectiveness of cyclic deformation-induced solute transport. Transparent elastic polyurethane scaffolds, with computer-programmed design of pore networks in the form of interconnected channels, were fabricated using a 3D printing and injection molding technique. The scaffold pores were loaded with a colored tracer for optical contrast, cyclically compressed with deformations of 10 and 15% of the original undeformed height at 1.0 Hz. Digital imaging was used to quantify the spatial distribution of the tracer concentration within the pores. Numerical simulations of a fluid-structure interaction model of deformation-induced solute transport were compared to the experimental data. The results of experiments and modeling agreed well and showed that pore interconnectivity heavily influences deformation-induced solute transport. Pore cross-sectional geometry appears to be of less relative importance in interconnected pore networks. Validated computer models of solute transport can be used to design optimal scaffold pore geometries that will enhance the convective transport of nutrients inside the scaffold and the removal of waste, thus improving the cell survivability deep inside the scaffold.

  1. Development of poly(trimethylene carbonate) network implants for annulus fibrosus tissue engineering.

    Science.gov (United States)

    Blanquer, Sébastien B G; Sharifi, Shahriar; Grijpma, Dirk W

    2012-01-01

    Intervertebral disk degeneration is the main cause of chronic back pain. Disk degeneration often leads to tearing of the annulus fibrosus (AF) and extrusion of the nucleus pulposus (NP), which compresses the nerves. Current treatment involves removing the herniated NP and suturing the damaged AF tissue. This surgical approach has several drawbacks. In this study, we designed a biodegradable AF closure system comprising a tissue engineering scaffold, a supporting membrane and an adhesive material, to not only restore the function of the herniated disc but also to promote tissue regeneration. Porous scaffolds with precisely defined architectures were built by stereolithography using resins based on poly(trimethylene carbonate) (PTMC) macromers functionalized with methacrylate endgroups. In addition, a porous photo-cross-linked PTMC membrane was developed that can be used to keep the scaffold in place in the AF tissue. After synthesis and characterization, the components of the implant are glued together and to the AF tissue using a diisocyanate glue based on polyethylene glycol-PTMC triblock copolymers. The adhesion strengths of the materials to each other and to AF tissue were determined in lap-shear tests. This study showed that a device for AF tissue engineering can be prepared from PTMC-based scaffolds, membranes and glues.

  2. Ado Vabbe preemia laureaat on Rauno Thomas Moss / Indrek Grigor

    Index Scriptorium Estoniae

    Grigor, Indrek

    2011-01-01

    2010. aasta Ado Vabbe preemia pälvinud Rauno Thomas Mossi loomingust, esinemisest näitustel. R. T. Moss on praegu TÜ semiootika ja maalikunsti osakonna õppejõud ning semiootika osakonna doktorant

  3. "I Cannot Live Without Books": Thomas Jefferson, Bibliophile

    Science.gov (United States)

    Ladenson, Alex

    1978-01-01

    The article discusses Thomas Jefferson's preoccupation with collecting books and some of his other intellectual pursuits, including the classification scheme he developed for his personal library. The sale of his personal library to the federal government is briefly described. (JPF)

  4. Thomas Jefferson, the Community College and the Pursuit of Education.

    Science.gov (United States)

    Vaughan, George B.

    1980-01-01

    Demonstrates the strong philosophical ties between Thomas Jefferson's views on public education and the modern day community college. Reviews Jefferson's proposals for publicly financed education and for increased access to education and discusses the mission of the community college. (AYC)

  5. Mission Specialist Donald A. Thomas prepares to enter Columbia

    Science.gov (United States)

    1997-01-01

    KENNEDY SPACE CENTER, FLA. -- STS-83 Mission Specialist Donald A. Thomas prepares to enter the Space Shuttle Columbia at Launch Pad 39A with assistance from white room closeout crew members (from left) Rick Welty, Bob Saulnier, and Rene Arriens.

  6. EAARL Topography-Thomas Stone National Historic Site

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — A first surface elevation map (also known as a Digital Elevation Model or DEM) of Thomas Stone National Historic Site was produced from remotely-sensed,...

  7. Biographical sketch: Thomas Callaway, FRCS (1822-1869).

    Science.gov (United States)

    Brand, Richard A

    2011-12-01

    This biographical sketch on Thomas Callaway corresponds to the historic text, The Classic: A Dissertation Upon Dislocations and Fractures of the Clavicle and Shoulder-Joint (1849) available at DOI 10.1007/s11999-011-2098-1 .

  8. St. Thomas and the Divine Origin of Law: Some Notes

    Directory of Open Access Journals (Sweden)

    Lawrence Dewan, O.P.

    2008-12-01

    Full Text Available This article presents a series of notes on the concept of Law and itsrelationship to God in Classical Antiquity, specifically taking into account the viewpoints of Aristotle and Saint Thomas Aquinas.

  9. Caribbean ST Thomas all gears Logbook Survey (Vessels)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains catch (landed catch) and effort for fishing trips made by vessels fishing in St. Thomas. The catch and effort data for the entire trip are...

  10. A fully-automated neural network analysis of AFM force-distance curves for cancer tissue diagnosis

    Science.gov (United States)

    Minelli, Eleonora; Ciasca, Gabriele; Sassun, Tanya Enny; Antonelli, Manila; Palmieri, Valentina; Papi, Massimiliano; Maulucci, Giuseppe; Santoro, Antonio; Giangaspero, Felice; Delfini, Roberto; Campi, Gaetano; De Spirito, Marco

    2017-10-01

    Atomic Force Microscopy (AFM) has the unique capability of probing the nanoscale mechanical properties of biological systems that affect and are affected by the occurrence of many pathologies, including cancer. This capability has triggered growing interest in the translational process of AFM from physics laboratories to clinical practice. A factor still hindering the current use of AFM in diagnostics is related to the complexity of AFM data analysis, which is time-consuming and needs highly specialized personnel with a strong physical and mathematical background. In this work, we demonstrate an operator-independent neural-network approach for the analysis of surgically removed brain cancer tissues. This approach allowed us to distinguish—in a fully automated fashion—cancer from healthy tissues with high accuracy, also highlighting the presence and the location of infiltrating tumor cells.

  11. Mueller-matrix mapping of biological tissues in differential diagnosis of optical anisotropy mechanisms of protein networks

    Energy Technology Data Exchange (ETDEWEB)

    Ushenko, V A; Sidor, M I [Yuriy Fedkovych Chernivtsi National University, Chernivtsi (Ukraine); Marchuk, Yu F; Pashkovskaya, N V; Andreichuk, D R [Bukovinian State Medical University, Chernivtsi (Ukraine)

    2015-03-31

    We report a model of Mueller-matrix description of optical anisotropy of protein networks in biological tissues with allowance for the linear birefringence and dichroism. The model is used to construct the reconstruction algorithms of coordinate distributions of phase shifts and the linear dichroism coefficient. In the statistical analysis of such distributions, we have found the objective criteria of differentiation between benign and malignant tissues of the female reproductive system. From the standpoint of evidence-based medicine, we have determined the operating characteristics (sensitivity, specificity and accuracy) of the Mueller-matrix reconstruction method of optical anisotropy parameters and demonstrated its effectiveness in the differentiation of benign and malignant tumours. (laser applications and other topics in quantum electronics)

  12. Tissue culture on a chip: Developmental biology applications of self-organized capillary networks in microfluidic devices.

    Science.gov (United States)

    Miura, Takashi; Yokokawa, Ryuji

    2016-08-01

    Organ culture systems are used to elucidate the mechanisms of pattern formation in developmental biology. Various organ culture techniques have been used, but the lack of microcirculation in such cultures impedes the long-term maintenance of larger tissues. Recent advances in microfluidic devices now enable us to utilize self-organized perfusable capillary networks in organ cultures. In this review, we will overview past approaches to organ culture and current technical advances in microfluidic devices, and discuss possible applications of microfluidics towards the study of developmental biology. © 2016 Japanese Society of Developmental Biologists.

  13. Tuning mechanical performance of poly(ethylene glycol) and agarose interpenetrating network hydrogels for cartilage tissue engineering.

    Science.gov (United States)

    Rennerfeldt, Deena A; Renth, Amanda N; Talata, Zsolt; Gehrke, Stevin H; Detamore, Michael S

    2013-11-01

    Hydrogels are attractive for tissue engineering applications due to their incredible versatility, but they can be limited in cartilage tissue engineering applications due to inadequate mechanical performance. In an effort to address this limitation, our team previously reported the drastic improvement in the mechanical performance of interpenetrating networks (IPNs) of poly(ethylene glycol) diacrylate (PEG-DA) and agarose relative to pure PEG-DA and agarose networks. The goal of the current study was specifically to determine the relative importance of PEG-DA concentration, agarose concentration, and PEG-DA molecular weight in controlling mechanical performance, swelling characteristics, and network parameters. IPNs consistently had compressive and shear moduli greater than the additive sum of either single network when compared to pure PEG-DA gels with a similar PEG-DA content. IPNs withstood a maximum stress of up to 4.0 MPa in unconfined compression, with increased PEG-DA molecular weight being the greatest contributing factor to improved failure properties. However, aside from failure properties, PEG-DA concentration was the most influential factor for the large majority of properties. Increasing the agarose and PEG-DA concentrations as well as the PEG-DA molecular weight of agarose/PEG-DA IPNs and pure PEG-DA gels improved moduli and maximum stresses by as much as an order of magnitude or greater compared to pure PEG-DA gels in our previous studies. Although the viability of encapsulated chondrocytes was not significantly affected by IPN formulation, glycosaminoglycan (GAG) content was significantly influenced, with a 12-fold increase over a three-week period in gels with a lower PEG-DA concentration. These results suggest that mechanical performance of IPNs may be tuned with partial but not complete independence from biological performance of encapsulated cells. © 2013 Elsevier Ltd. All rights reserved.

  14. Thomas Mann: um escritor contra o nazismo Thomas Mann: a writer against nazism

    Directory of Open Access Journals (Sweden)

    Sonia Dayan-Herzbrun

    1997-01-01

    Full Text Available O combate que Thomas Mann travou contra o nazismo a partir de 1922 é exemplar, pois é o de um escritor apaixonado pela liberdade e não o de um militante. Ele privilegia a ficção e o mito como meios de luta contra o fascínio exercido pelo nazismo e afirma a permanência de uma Alemanha cultural, cosmopolita, fonte de uma universalidade estranha a todos os particularismos étnicos. Goethe, com quem ele se identifica e no qual se projeta, é a figura de proa dessa Alemanha.Thomas Mann's attack, from 1922 onwards, against Nazism is exemplar in the sense that it was promoted by a writer committed to the defence of liberty and not by a militant. He underlines fiction and myth as ways of fighting against the charms of Nazism and proclaims the permanence of a cultural, cosmopolitan Germany, a source of a universality which is alien to all kinds of ethnic particularities. Goethe, someone he is identified with, is the prominent figure of this Germany.

  15. Relativistic finite-temperature Thomas-Fermi model

    Science.gov (United States)

    Faussurier, Gérald

    2017-11-01

    We investigate the relativistic finite-temperature Thomas-Fermi model, which has been proposed recently in an astrophysical context. Assuming a constant distribution of protons inside the nucleus of finite size avoids severe divergence of the electron density with respect to a point-like nucleus. A formula for the nuclear radius is chosen to treat any element. The relativistic finite-temperature Thomas-Fermi model matches the two asymptotic regimes, i.e., the non-relativistic and the ultra-relativistic finite-temperature Thomas-Fermi models. The equation of state is considered in detail. For each version of the finite-temperature Thomas-Fermi model, the pressure, the kinetic energy, and the entropy are calculated. The internal energy and free energy are also considered. The thermodynamic consistency of the three models is considered by working from the free energy. The virial question is also studied in the three cases as well as the relationship with the density functional theory. The relativistic finite-temperature Thomas-Fermi model is far more involved than the non-relativistic and ultra-relativistic finite-temperature Thomas-Fermi models that are very close to each other from a mathematical point of view.

  16. Functional and gene network analyses of transcriptional signatures characterizing pre-weaned bovine mammary parenchyma or fat pad uncovered novel inter-tissue signaling networks during development

    Directory of Open Access Journals (Sweden)

    Lewin Harris A

    2010-05-01

    Full Text Available Abstract Background The neonatal bovine mammary fat pad (MFP surrounding the mammary parenchyma (PAR is thought to exert proliferative effects on the PAR through secretion of local modulators of growth induced by systemic hormones. We used bioinformatics to characterize transcriptomics differences between PAR and MFP from ~65 d old Holstein heifers. Data were mined to uncover potential crosstalk through the analyses of signaling molecules preferentially expressed in one tissue relative to the other. Results Over 9,000 differentially expressed genes (DEG; False discovery rate ≤ 0.05 were found of which 1,478 had a ≥1.5-fold difference between PAR and MFP. Within the DEG highly-expressed in PAR vs. MFP (n = 736 we noted significant enrichment of functions related to cell cycle, structural organization, signaling, and DNA/RNA metabolism. Only actin cytoskeletal signaling was significant among canonical pathways. DEG more highly-expressed in MFP vs. PAR (n = 742 belong to lipid metabolism, signaling, cell movement, and immune-related functions. Canonical pathways associated with metabolism and signaling, particularly immune- and metabolism-related were significantly-enriched. Network analysis uncovered a central role of MYC, TP53, and CTNNB1 in controlling expression of DEG highly-expressed in PAR vs. MFP. Similar analysis suggested a central role for PPARG, KLF2, EGR2, and EPAS1 in regulating expression of more highly-expressed DEG in MFP vs. PAR. Gene network analyses revealed putative inter-tissue crosstalk between cytokines and growth factors preferentially expressed in one tissue (e.g., ANGPTL1, SPP1, IL1B in PAR vs. MFP; ADIPOQ, IL13, FGF2, LEP in MFP vs. PAR with DEG preferentially expressed in the other tissue, particularly transcription factors or pathways (e.g., MYC, TP53, and actin cytoskeletal signaling in PAR vs. MFP; PPARG and LXR/RXR Signaling in MFP vs. PAR. Conclusions Functional analyses underscored a reciprocal influence in

  17. Thomas Pavel, Come ascoltare la letteratura? Thomas Pavel, Come ascoltare la letteratura? Thomas Pavel, How Can We Listen to Literature

    Directory of Open Access Journals (Sweden)

    Antonio Sotgiu

    2009-06-01

    Full Text Available Nella prolusione al suo corso al Collège de France, pronunciata il 6 aprile 2006, Thomas Pavel si interroga sugli aspetti emotivi ed etici dell'attività della lettura, sull'“abbandonarsi” di chi legge all'opera letteraria. Come avviene la trasfigurazione del quotidiano nel mondo finzionale? Come si svolge il processo di identificazione dell'io nell'opera? Lo studioso rintraccia il fondamento di tale processo nella non coincidenza di principio tra io e vita, quindi nella facoltà del lettore di accogliere e riconoscere il senso dell'opera. Un senso che tuttavia non si palesa una volta per tutte nella sua interezza e trasparenza, ma che diviene oggetto di continuo dialogo fra i lettori, un senso quindi affidato alle loro cure.During the opening lecture of his course at Collège de France, held on April 6th 2006, Thomas Pavel talks about the emotional and ethical aspects of reading and about «completely surrending» to literature. How is everyday life transfigured into poetic invention? How is our ego identified in the literary work? The scholar traces the origin of this process to the radically different principles governing ego and life. Because of this, the reader is able to grasp and understand the real meaning of the book. This, however, is never completely revealed in a clear way. Instead, it becomes the object of a never-ending dialogue among the readers: it is therefore their care the meaning is entrusted to.Во вступлении к своему курсу лекций во Французском Колледже, произнесенном 6-го апреля 2006-го года, Томас Павел размышляет о эмоциональных и этических сторонах чтения, о том, как читатель «отдается» литературному произведению. Как

  18. Characterizing genes with distinct methylation patterns in the context of protein-protein interaction network: application to human brain tissues.

    Science.gov (United States)

    Li, Yongsheng; Xu, Juan; Chen, Hong; Zhao, Zheng; Li, Shengli; Bai, Jing; Wu, Aiwei; Jiang, Chunjie; Wang, Yuan; Su, Bin; Li, Xia

    2013-01-01

    DNA methylation is an essential epigenetic mechanism involved in transcriptional control. However, how genes with different methylation patterns are assembled in the protein-protein interaction network (PPIN) remains a mystery. In the present study, we systematically dissected the characterization of genes with different methylation patterns in the PPIN. A negative association was detected between the methylation levels in the brain tissues and topological centralities. By focusing on two classes of genes with considerably different methylation levels in the brain tissues, namely the low methylated genes (LMGs) and high methylated genes (HMGs), we found that their organizing principles in the PPIN are distinct. The LMGs tend to be the center of the PPIN, and attacking them causes a more deleterious effect on the network integrity. Furthermore, the LMGs express their functions in a modular pattern and substantial differences in functions are observed between the two types of genes. The LMGs are enriched in the basic biological functions, such as binding activity and regulation of transcription. More importantly, cancer genes, especially recessive cancer genes, essential genes, and aging-related genes were all found more often in the LMGs. Additionally, our analysis presented that the intra-classes communications are enhanced, but inter-classes communications are repressed. Finally, a functional complementation was revealed between methylation and miRNA regulation in the human genome. We have elucidated the assembling principles of genes with different methylation levels in the context of the PPIN, providing key insights into the complex epigenetic regulation mechanisms.

  19. Endothelial cells assemble into a 3-dimensional prevascular network in a bone tissue engineering construct

    NARCIS (Netherlands)

    Rouwkema, Jeroen; de Boer, Jan; van Blitterswijk, Clemens

    2006-01-01

    To engineer tissues with clinically relevant dimensions, one must overcome the challenge of rapidly creating functional blood vessels to supply cells with oxygen and nutrients and to remove waste products. We tested the hypothesis that endothelial cells, cocultured with osteoprogenitor cells, can

  20. Obituary: Thomas Robert Metcalf, 1961-2007

    Science.gov (United States)

    Leka, K. D.

    2007-12-01

    The astronomy community lost a good friend when Tom Metcalf was killed in a skiing accident on Saturday, 7 July 2007, in the mountains near Boulder, Colorado. Tom was widely known for prolific work on solar magnetic fields, hard-X-ray imaging of solar flares, and spectral line diagnostics. He was often characterized as "one of the nicest guys in science." Born October 5, 1961 in Cheverly, Maryland, to Fred and Marilyn, Thomas R. Metcalf joined his sister, Karen, two years his elder, in a close family that loved sailing, inquisitiveness, and the natural world. Sibling rivalry (usually a Tonka truck intruding on Barbie's sub-table "castle") melted when Tom and Karen collaborated on elaborately engineered room-sized blanket-forts. Tom confidently signed up at age of three to crew for his family's sailboat; when the family moved to California in 1966, as Tom's father took a Professor of Mathematics position at the University of California Riverside, Tom's love for sailing was well-established. Week-long cruises or short trips in the harbor were all fun; when school friends came aboard, it was even better--if "only slightly too crowded" from the adults' points of view. Tom's introduction to astronomy began one cold, very clear, December night in the early 1970s, on a family camping trip to Death Valley. The "Sidewalk Astronomers of San Francisco" had lined the sidewalk near the visitors' center with all sorts of telescopes for public viewing. Soon after, Tom and his boyhood friend Jim O'Linger were building their own scopes, attending "Amateur Telescope Makers" conferences, and Tom was setting up his scope on a sidewalk for public viewing. In 1986, Tom set up his telescope on the bluffs above Dana Point Harbor, and gave numerous strangers a stunning view of Halley's Comet. His interest in physics and mathematics became evident during Tom's last years in high school (Poly High in Riverside), and as a senior he qualified to take freshman Physics at the University of

  1. Transplantation of tissue engineering neural network and formation of neuronal relay into the transected rat spinal cord.

    Science.gov (United States)

    Lai, Bi-Qin; Che, Ming-Tian; Du, Bao-Ling; Zeng, Xiang; Ma, Yuan-Huan; Feng, Bo; Qiu, Xue-Chen; Zhang, Ke; Liu, Shu; Shen, Hui-Yong; Wu, Jin-Lang; Ling, Eng-Ang; Zeng, Yuan-Shan

    2016-12-01

    Severe spinal cord injury (SCI) causes loss of neural connectivity and permanent functional deficits. Re-establishment of new neuronal relay circuits after SCI is therefore of paramount importance. The present study tested our hypothesis if co-culture of neurotrophin-3 (NT-3) gene-modified Schwann cells (SCs, NT-3-SCs) and TrkC (NT-3 receptor) gene-modified neural stem cells (NSCs, TrkC-NSCs) in a gelatin sponge scaffold could construct a tissue engineering neural network for re-establishing an anatomical neuronal relay after rat spinal cord transection. Eight weeks after transplantation, the neural network created a favorable microenvironment for axonal regeneration and for survival and synaptogenesis of NSC-derived neurons. Biotin conjugates of cholera toxin B subunit (b-CTB, a transneuronal tracer) was injected into the crushed sciatic nerve to label spinal cord neurons. Remarkably, not only ascending and descending nerve fibers, but also propriospinal neurons, made contacts with b-CTB positive NSC-derived neurons. Moreover, b-CTB positive NSC-derived neurons extended their axons making contacts with the motor neurons located in areas caudal to the injury/graft site of spinal cord. Further study showed that NT-3/TrkC interactions activated the PI3K/AKT/mTOR pathway and PI3K/AKT/CREB pathway affecting synaptogenesis of NSC-derived neurons. Together, our findings suggest that NT-3-mediated TrkC signaling plays an essential role in constructing a tissue engineering neural network thus representing a promising avenue for effective exogenous neuronal relay-based treatment for SCI. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. Deep convolutional neural network and 3D deformable approach for tissue segmentation in musculoskeletal magnetic resonance imaging.

    Science.gov (United States)

    Liu, Fang; Zhou, Zhaoye; Jang, Hyungseok; Samsonov, Alexey; Zhao, Gengyan; Kijowski, Richard

    2017-07-21

    To describe and evaluate a new fully automated musculoskeletal tissue segmentation method using deep convolutional neural network (CNN) and three-dimensional (3D) simplex deformable modeling to improve the accuracy and efficiency of cartilage and bone segmentation within the knee joint. A fully automated segmentation pipeline was built by combining a semantic segmentation CNN and 3D simplex deformable modeling. A CNN technique called SegNet was applied as the core of the segmentation method to perform high resolution pixel-wise multi-class tissue classification. The 3D simplex deformable modeling refined the output from SegNet to preserve the overall shape and maintain a desirable smooth surface for musculoskeletal structure. The fully automated segmentation method was tested using a publicly available knee image data set to compare with currently used state-of-the-art segmentation methods. The fully automated method was also evaluated on two different data sets, which include morphological and quantitative MR images with different tissue contrasts. The proposed fully automated segmentation method provided good segmentation performance with segmentation accuracy superior to most of state-of-the-art methods in the publicly available knee image data set. The method also demonstrated versatile segmentation performance on both morphological and quantitative musculoskeletal MR images with different tissue contrasts and spatial resolutions. The study demonstrates that the combined CNN and 3D deformable modeling approach is useful for performing rapid and accurate cartilage and bone segmentation within the knee joint. The CNN has promising potential applications in musculoskeletal imaging. Magn Reson Med, 2017. © 2017 International Society for Magnetic Resonance in Medicine. © 2017 International Society for Magnetic Resonance in Medicine.

  3. Guest Foreword from Michael Thomas CMG QC

    Directory of Open Access Journals (Sweden)

    Michael Thomas

    2012-04-01

    precedents and thought in a unique legal market in which ideas drawn from Islamic law, civil law and common law can intermingle and blend. It is not surprising therefore to see that this new publication will be dedicated to the subject of international law, both public and private. Its laudable aim is to promote legal discourse around the world, and to promote a wider international understanding of contemporary legal issues for the common benefit. As an open access, bilingual journal, addressing topics concerning any jurisdiction, I hope it will reach a wide audience, and fulfil its aim of promoting understanding between different cultures. I am sure that the journal will not only benefit Qatar’s legal community by advancing academic and practice-based legal discussion. I am also confident that it will stimulate thought in the global legal community at large. May I wish it every success and a long life. Michael Thomas CMG QC

  4. Obituary: Thomas Michael Donahue, 1921-2004

    Science.gov (United States)

    Gombosi, Tamás I.

    2004-12-01

    Thomas M. Donahue, one of the nation's leading space and planetary scientists and a pioneer of space exploration, died Saturday October 16, 2004, from complications following heart surgery. The Edward H. White II Distinguished University Professor of Planetary Science at the University of Michigan, Tom shaped space exploration through his scientific achievements and policy positions. His work started with the first use of sounding rockets following World War II and continued for almost 60 years. Tom was born in Healdton, Oklahoma on May 23, 1921 to Robert Emmet and Mary (Lyndon) Donahue. His father was a plumber in the oil fields when Tom was born (Healdton OK was an oil town) and worked as a plumber in Kansas City for a time. Tom grew up in Kansas City, graduating in 1942 from Rockhurst College in that city with degrees in classics and physics. His graduate work in physics at Johns Hopkins University was interrupted by service in the Army Signal Corps. He obtained his PhD degree in atomic physics from Hopkins in the fall of 1947. After three years as a post-doctoral research associate and assistant professor at Hopkins, Tom joined the University of Pittsburgh Physics Department in 1951. At Pittsburgh he organized an atomic physics and atmospheric science program that led to experimental and theoretical studies of the upper atmosphere of the Earth and other solar system planets with instruments flown on sounding rockets and spacecraft. He became Professor of Physics in 1959 and eventually Director of the Laboratory for Atmospheric and Space Sciences and the Space Research Coordination Center at the University. In 1960 he spent a sabbatical year on a Guggenheim Fellowship at the Service d'Aeronomie in Paris, which began collaborations with French colleagues that flourished for more than 40 years. In 1974 he became the Chairman of the Atmospheric and Oceanic Science Department, University of Michigan, a position he held until 1981. In 1986, he was named the Henry

  5. Rapid Alterations in Perirenal Adipose Tissue Transcriptomic Networks with Cessation of Voluntary Running

    OpenAIRE

    Ruegsegger, Gregory N.; Company, Joseph M.; Toedebusch, Ryan G.; Roberts, Christian K.; Roberts, Michael D.; Booth, Frank W.

    2015-01-01

    In maturing rats, the growth of abdominal fat is attenuated by voluntary wheel running. After the cessation of running by wheel locking, a rapid increase in adipose tissue growth to a size that is similar to rats that have never run (i.e. catch-up growth) has been previously reported by our lab. In contrast, diet-induced increases in adiposity have a slower onset with relatively delayed transcriptomic responses. The purpose of the present study was to identify molecular pathways associated wi...

  6. A heart-brain-kidney network controls adaptation to cardiac stress through tissue macrophage activation.

    Science.gov (United States)

    Fujiu, Katsuhito; Shibata, Munehiko; Nakayama, Yukiteru; Ogata, Fusa; Matsumoto, Sahohime; Noshita, Koji; Iwami, Shingo; Nakae, Susumu; Komuro, Issei; Nagai, Ryozo; Manabe, Ichiro

    2017-05-01

    Heart failure is a complex clinical syndrome characterized by insufficient cardiac function. In addition to abnormalities intrinsic to the heart, dysfunction of other organs and dysregulation of systemic factors greatly affect the development and consequences of heart failure. Here we show that the heart and kidneys function cooperatively in generating an adaptive response to cardiac pressure overload. In mice subjected to pressure overload in the heart, sympathetic nerve activation led to activation of renal collecting-duct (CD) epithelial cells. Cell-cell interactions among activated CD cells, tissue macrophages and endothelial cells within the kidney led to secretion of the cytokine CSF2, which in turn stimulated cardiac-resident Ly6Clo macrophages, which are essential for the myocardial adaptive response to pressure overload. The renal response to cardiac pressure overload was disrupted by renal sympathetic denervation, adrenergic β2-receptor blockade or CD-cell-specific deficiency of the transcription factor KLF5. Moreover, we identified amphiregulin as an essential cardioprotective mediator produced by cardiac Ly6Clo macrophages. Our results demonstrate a dynamic interplay between the heart, brain and kidneys that is necessary for adaptation to cardiac stress, and they highlight the homeostatic functions of tissue macrophages and the sympathetic nervous system.

  7. Tissue and cell-type co-expression networks of transcription factors and wood component genes in Populus trichocarpa.

    Science.gov (United States)

    Shi, Rui; Wang, Jack P; Lin, Ying-Chung; Li, Quanzi; Sun, Ying-Hsuan; Chen, Hao; Sederoff, Ronald R; Chiang, Vincent L

    2017-05-01

    Co-expression networks based on transcriptomes of Populus trichocarpa major tissues and specific cell types suggest redundant control of cell wall component biosynthetic genes by transcription factors in wood formation. We analyzed the transcriptomes of five tissues (xylem, phloem, shoot, leaf, and root) and two wood forming cell types (fiber and vessel) of Populus trichocarpa to assemble gene co-expression subnetworks associated with wood formation. We identified 165 transcription factors (TFs) that showed xylem-, fiber-, and vessel-specific expression. Of these 165 TFs, 101 co-expressed (correlation coefficient, r > 0.7) with the 45 secondary cell wall cellulose, hemicellulose, and lignin biosynthetic genes. Each cell wall component gene co-expressed on average with 34 TFs, suggesting redundant control of the cell wall component gene expression. Co-expression analysis showed that the 101 TFs and the 45 cell wall component genes each has two distinct groups (groups 1 and 2), based on their co-expression patterns. The group 1 TFs (44 members) are predominantly xylem and fiber specific, and are all highly positively co-expressed with the group 1 cell wall component genes (30 members), suggesting their roles as major wood formation regulators. Group 1 TFs include a lateral organ boundary domain gene (LBD) that has the highest number of positively correlated cell wall component genes (36) and TFs (47). The group 2 TFs have 57 members, including 14 vessel-specific TFs, and are generally less correlated with the cell wall component genes. An exception is a vessel-specific basic helix-loop-helix (bHLH) gene that negatively correlates with 20 cell wall component genes, and may function as a key transcriptional suppressor. The co-expression networks revealed here suggest a well-structured transcriptional homeostasis for cell wall component biosynthesis during wood formation.

  8. Convolutional neural networks for an automatic classification of prostate tissue slides with high-grade Gleason score

    Science.gov (United States)

    Jiménez del Toro, Oscar; Atzori, Manfredo; Otálora, Sebastian; Andersson, Mats; Eurén, Kristian; Hedlund, Martin; Rönnquist, Peter; Müller, Henning

    2017-03-01

    The Gleason grading system was developed for assessing prostate histopathology slides. It is correlated to the outcome and incidence of relapse in prostate cancer. Although this grading is part of a standard protocol performed by pathologists, visual inspection of whole slide images (WSIs) has an inherent subjectivity when evaluated by different pathologists. Computer aided pathology has been proposed to generate an objective and reproducible assessment that can help pathologists in their evaluation of new tissue samples. Deep convolutional neural networks are a promising approach for the automatic classification of histopathology images and can hierarchically learn subtle visual features from the data. However, a large number of manual annotations from pathologists are commonly required to obtain sufficient statistical generalization when training new models that can evaluate the daily generated large amounts of pathology data. A fully automatic approach that detects prostatectomy WSIs with high-grade Gleason score is proposed. We evaluate the performance of various deep learning architectures training them with patches extracted from automatically generated regions-of-interest rather than from manually segmented ones. Relevant parameters for training the deep learning model such as size and number of patches as well as the inclusion or not of data augmentation are compared between the tested deep learning architectures. 235 prostate tissue WSIs with their pathology report from the publicly available TCGA data set were used. An accuracy of 78% was obtained in a balanced set of 46 unseen test images with different Gleason grades in a 2-class decision: high vs. low Gleason grade. Grades 7-8, which represent the boundary decision of the proposed task, were particularly well classified. The method is scalable to larger data sets with straightforward re-training of the model to include data from multiple sources, scanners and acquisition techniques. Automatically

  9. Primary care clinicians' perspectives on management of skin and soft tissue infections: an Iowa Research Network study.

    Science.gov (United States)

    Daly, Jeanette M; Ely, John W; Levy, Barcey T; Smith, Tara C; Merchant, Mary L; Bergus, George R; Jogerst, Gerald J

    2011-01-01

    An estimated 95,000 people developed methicillin-resistant Staphylococcus aureus (MRSA) infections during 2005 of which 14% were community-associated and 85% were hospital or other health setting associated, and 19,000 Americans died from these infections that year. To explore health care providers' perspectives on management of skin and soft tissue infections to gain a better understanding of the problems faced by busy providers in primary care settings. Focus group meetings were held at 9 family physician offices in the Iowa Research Network. Seventy-eight clinicians including physicians, nurses, nurse practitioners, and house officers attended. Meeting audiotapes were transcribed and coded by 3 investigators, and a MRSA-management taxonomy was developed. The main themes that emerged from the focus groups included epidemiology, diagnosis, treatment, management, prevention, special populations, and public relations. The incidence of MRSA infections was perceived to have increased over the past decade. However, diagnosis and treatment protocols for physicians in the outpatient setting have lagged behind, and no well-accepted diagnostic or treatment algorithms were used by physicians attending the focus groups. The clinicians in this study noted considerable confusion and inconsistency in the management of skin and soft tissue infections, particularly those due to MRSA. © 2010 National Rural Health Association.

  10. Obituary: Thomas Julian Ahrens (1936-2010)

    Science.gov (United States)

    Jeanloz, Raymond; Asimow, Paul

    2011-12-01

    Thomas J. Ahrens, a leader in the use of shock waves to study planetary interiors and impact phenomena, died at his home in Pasadena, California on November 24, 2010, at the age of 74. He was the California Institute of Technology's Fletcher Jones Professor of Geophysics, formally emeritus since 2005 but professionally active to the end. Tom was a pioneer in experimental and numerical studies of the effects of hypervelocity impact, arguably the most important geophysical process in the formation, growth and - in many cases - surface evolution of planets. As a professor at Caltech, he established the foremost university laboratory for shock wave experiments, where students and research associates from around the world pursued basic research in geophysics, planetary science and other disciplines. Previously, high-pressure shock experiments were primarily conducted in national laboratories, where they were initially associated with development of nuclear weapons. The shock wave laboratory at Caltech was noted for key measurements addressing major questions in planetary geophysics. Equation-of-state studies on silicate melts showed that magma deep in Earth's mantle could be denser than the coexisting crystals, implying downward transport of melts (and associated heat) rather than the upward eruption of lavas observed in volcanic regions at Earth's surface. Shock-melting experiments on iron at pressures of Earth's core provide a crucial constraint on the temperature at the center of our planet. And studies of hydrous, carbonate and sulphate minerals under shock compression document how climate-altering molecules can be released by major impacts, such as the K/T event associated with the most recent mass extinction of biota in Earth history. In addition, Tom was a leader in numerical simulation of cratering, bringing the most recent laboratory measurements into the modeling of planetary impacts. Tom's training was in geophysics and applied experimental physics, as

  11. Transcriptional Networks in Single Perivascular Cells Sorted from Human Adipose Tissue Reveal a Hierarchy of Mesenchymal Stem Cells.

    Science.gov (United States)

    Hardy, W Reef; Moldovan, Nicanor I; Moldovan, Leni; Livak, Kenneth J; Datta, Krishna; Goswami, Chirayu; Corselli, Mirko; Traktuev, Dmitry O; Murray, Iain R; Péault, Bruno; March, Keith

    2017-05-01

    Adipose tissue is a rich source of multipotent mesenchymal stem-like cells, located in the perivascular niche. Based on their surface markers, these have been assigned to two main categories: CD31 - /CD45 - /CD34 + /CD146 - cells (adventitial stromal/stem cells [ASCs]) and CD31 - /CD45 - /CD34 - /CD146 + cells (pericytes [PCs]). These populations display heterogeneity of unknown significance. We hypothesized that aldehyde dehydrogenase (ALDH) activity, a functional marker of primitivity, could help to better define ASC and PC subclasses. To this end, the stromal vascular fraction from a human lipoaspirate was simultaneously stained with fluorescent antibodies to CD31, CD45, CD34, and CD146 antigens and the ALDH substrate Aldefluor, then sorted by fluorescence-activated cell sorting. Individual ASCs (n = 67) and PCs (n = 73) selected from the extremities of the ALDH-staining spectrum were transcriptionally profiled by Fluidigm single-cell quantitative polymerase chain reaction for a predefined set (n = 429) of marker genes. To these single-cell data, we applied differential expression and principal component and clustering analysis, as well as an original gene coexpression network reconstruction algorithm. Despite the stochasticity at the single-cell level, covariation of gene expression analysis yielded multiple network connectivity parameters suggesting that these perivascular progenitor cell subclasses possess the following order of maturity: (a) ALDH br ASC (most primitive); (b) ALDH dim ASC; (c) ALDH br PC; (d) ALDH dim PC (least primitive). This order was independently supported by specific combinations of class-specific expressed genes and further confirmed by the analysis of associated signaling pathways. In conclusion, single-cell transcriptional analysis of four populations isolated from fat by surface markers and enzyme activity suggests a developmental hierarchy among perivascular mesenchymal stem cells supported by markers and coexpression

  12. Bone cement with a modified polyphosphate network structure stimulates hard tissue regeneration.

    Science.gov (United States)

    Lee, Byung-Hyun; Hong, Min-Ho; Kim, Min-Chul; Kwon, Jae-Sung; Ko, Yeong-Mu; Choi, Heon-Jin; Lee, Yong-Keun

    2016-09-01

    In this study, a calcium polyphosphate cement (CpPC) consisting of basic components was investigated to assess its potential for hard tissue regeneration. The added basic components for improving the structural stability, which controlled the setting time, where the setting reaction resulted in the formation of amorphous structure with a re-constructed polyphosphate. Moreover, the characteristics were controlled by the composition, which determined the polyphosphate structure. CpPC exhibited outstanding dissolution rate compared with the common biodegradable cement, brushite cement (2.5 times). Despite high amounts of dissolution products, no significant cytotoxicity ensued. Induction of calcification in MG-63 cells treated with CpPC, the level of calcification increased with increasing CpPC dissolution rate. Induced calcification was observed also in CpPC-treated ST2 cells, in contrast with MG-63 and ST2 treated with brushite cement, for which no calcification was observed. In vivo tests using a rat calvarial defect model showed that resorbed CpPC resulted in favorable host responses and promoted bone formation. Additionally, there was a significant increase in defect closure, and new bone formation progressed from CpPC mid-sites as well as defect margins. From these results, CpPC exhibits significant potential as biodegradable bone substitute for bone regeneration. © The Author(s) 2016.

  13. Obituary: Thomas Gold, 1920-2004

    Science.gov (United States)

    Dermott, Stanley F.

    2004-12-01

    Thomas "Tommy" Gold died of heart disease at Cayuga Medical Center, Ithaca NY on 22 June 2004 at the age of 84. He will be remembered as one of the most interesting, dynamic and influential scientists of his generation. Tommy's paradigm-changing ideas in astronomy and planetary science, while original and bold, were also highly controversial. With his radical work on the origin of natural gas and petroleum, the controversy is likely to continue. Tommy was born in Vienna, Austria on 22 May 1920, moving with his family to Berlin at age 10 and then, after the rise of Hitler in 1933, to England. His parents were Josephine (nee Martin) and Maximillian Gold, a successful steel magnate. Tommy was educated at Zuoz College in Switzerland where he became an expert skier and developed an athletic prowess that he maintained throughout his life, winning a NASTAR gold medal for skiing at the age of 65. He studied Mechanical Sciences at Trinity College, Cambridge, but much to his disgust his education was interrupted because of internment by the British as a suspected enemy alien. That unfortunate period (I remember him saying to me "Can you believe the stupidity, interring people like me who had fled from Nazi Germany?") had one good outcome: on his first night in camp he met Hermann Bondi who had an important influence on his early development as a scientist. They were both born in Vienna, their parents knew each other, and they were fellow students at Trinity, but this was their first meeting. On release, he went immediately into top-secret radar research for the British Admiralty, working as a team with Bondi and Fred Hoyle in a farm cottage in Dunsfold, Surrey. Tommy's first published research, which was a Nature paper with R.J. Pumphrey in 1947, was not in astronomy but physiology. He applied his engineer's understanding of positive feedback to develop and test a resonance model for how the human ear determines pitch. His conclusion that pitch discrimination occurs

  14. Thomas Alva Edison-Contributions to Entertainment and ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 5; Issue 1. Thomas Alva Edison - Contributions to Entertainment and Communications. K D Pavate. General Article Volume 5 Issue 1 January 2000 pp 71-75. Fulltext. Click here to view fulltext PDF. Permanent link:

  15. Counseling Implications of Genetic Research: A Dialogue with Thomas Bouchard.

    Science.gov (United States)

    Skovholt, Thomas M.

    1990-01-01

    Presents interview with Thomas Bouchard, a leading researcher of identical twins reared apart. Describes major themes in the Minnesota twin research. Claims, although genetic influence is central, Bouchard pleas for the impact of environmental factors in optimal human development. Includes Bouchard's surprising experiences, current focus, and…

  16. Mind the Screen : Media Concepts According to Thomas Elsaesser

    NARCIS (Netherlands)

    2008-01-01

    Mind the Screen is een hommage aan Thomas Elsaesser, pionier en toonaangevend wetenschapper in film- en mediastudies. De bijdragen bestrijken een groot media gebied, variërend van melodrama, gemediatiseerde herinneringen, de "mind-game film"en Europese cinema tot avant garde kunst, media archeologie

  17. Thomas Jefferson: The Architect of Democracy. Classroom Focus.

    Science.gov (United States)

    Peterson, Merrill D.

    1994-01-01

    Presents a biographical sketch and teaching activities on the life of Thomas Jefferson. Asserts that the world's political geography changed dramatically during his lifetime and presents a classroom lesson on this topic. Includes a chronology of Jefferson's life and six quotations exemplifying his political and social views. (CFR)

  18. Thomas Jefferson and Slaves: Teaching an American Paradox. Lesson Plan.

    Science.gov (United States)

    Fehn, Bruce

    2000-01-01

    Provides 11 primary sources that enable students to contemplate how Thomas Jefferson and his slaves produced a culture and community at Monticello (Virginia) and his other plantations. Focuses on Jefferson's relationship with his slaves, particularly addressing Sally Hemming's relationship with Jefferson, in order to study the complicated history…

  19. The World of Thomas Jefferson: A Guide for Teachers.

    Science.gov (United States)

    Valand, Elisabeth, Ed.

    This teaching guide contains two essays about Thomas Jefferson, along with teaching activities, resources and organizations, a chronology, and quotes. The two essays are: (1) "The Architect of Democracy" (Merrill D. Peterson); and (2) "Jefferson's Legacy: Civic Learning in Public Education" (R. Freeman Butts). Teaching…

  20. M O Ikeke Appraisal of Thomas Berry's Idea of Technological ...

    African Journals Online (AJOL)

    Oduor

    The paper concludes that oil technology is not essentially undesirable, but can actually be used to positively transform the Niger Delta. The paper contributes to efforts at promoting ecological conservation. Key Words. Thomas Berry, Technology, Oil, Niger Delta, environment, philosophy. Introduction. Technology is a neutral ...

  1. The Invention Factory: Thomas Edison's Laboratories. Teaching with Historic Places.

    Science.gov (United States)

    Bolger, Benjamin

    This lesson explores the group of buildings in West Orange, New Jersey, built in 1887, that formed the core of Thomas Edison's research and development complex. They consisted of chemistry, physics, and metallurgy laboratories; machine shop; pattern shop; research library; and rooms for experiments. The lesson explains that the prototypes (ideas…

  2. Teaching with Purpose: An Interview with Thomas E. Ludwig

    Science.gov (United States)

    Ludwig, Timothy D.; Ludwig, David J.

    2010-01-01

    Thomas E. Ludwig is the John Dirk Werkman Professor of Psychology at Hope College, where he joined the faculty in 1977 after receiving his PhD in development and aging from Washington University in St. Louis. His research focuses on developmental issues in cognitive neuropsychology. He is also the author or coauthor of more than a dozen sets of…

  3. Thomas Secker M.D.: Archbishop and man-midwife.

    Science.gov (United States)

    Morgan-Guy, John

    2018-01-01

    This paper provides a biographical outline of the career of Thomas Secker, MD, who from 1758-68 was Archbishop of Canterbury. Although much has been written on Secker, this study seeks to highlight his training in medicine, which has been largely overlooked hitherto by historians.

  4. Towards silence: Thomas Mofolo, small literatures and poor translation

    African Journals Online (AJOL)

    Despite having written three novels in the first decade of the 20th century, Thomas Mofolo has been largely ignored by historians of literature. The story of the translations of his novels, from 1930 onwards is that of misconceptions and serious misunderstandings. The originality and the complexity of the works discouraged ...

  5. Pioneers in South African Anaesthesia: Thomas Voss and the ...

    African Journals Online (AJOL)

    Pioneers in South African Anaesthesia: Thomas Voss and the “Elephant Tube”. R Hofmeyr, PC Gordon. Abstract. South Afr J Anaesth Analg 2013;19(5):239-241. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.1080/22201173.2013.

  6. Biographical sketch: Thomas W. Huntington, MD (1849-1929).

    Science.gov (United States)

    Brand, Richard A

    2012-10-01

    This biographical sketch on Thomas Huntington corresponds to the historic text, The classic: case of bone transference. use of a segment of fibula to supply a defect in the tibia (1905), available at DOI 10.1007/s11999-012-2496-z .

  7. Thomas Hunt Morgan and the Rise of Genetics

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 11. Thomas Hunt Morgan and the Rise of Genetics. Amitabh Joshi. Article-in-a-Box Volume 8 ... Author Affiliations. Amitabh Joshi1. Animal Behaviour Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560 064. India.

  8. Retrospective: "Futki" and Some Other Elephants | Thomas | Uganda ...

    African Journals Online (AJOL)

    Retrospective: "Futki" and Some Other Elephants. HB Thomas. Abstract. No Abstract. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.4314/uj.v48i1.23010 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians ...

  9. Scientific Aspects of Two Theological Questions in Thomas Aquinas.

    Science.gov (United States)

    Lattis, James M.

    1984-01-01

    An examination of how St. Thomas Aquinas makes use of science in his theological works provides an understanding of the relations of medieval science and the Christian theology of the Middle Ages. Two issues are examined: the problem of the nature and existence of God and the question of the eternity of the world. (RM)

  10. Thomas Aquinas on the Beatitudes : Edition of the Basel Manuscript

    NARCIS (Netherlands)

    ten Klooster, Anton

    2017-01-01

    There is a renewed interest in Thomas Aquinas’ interpretation of the beatitudes. An important source for the study of the beatitudes is Aquinas’ commentary on the gospel of Matthew. However, the available editions of this commentary present a text that ignores the oldest manuscript, and has

  11. Insights into translation and the original text: Thomas Mofolo's Chaka

    African Journals Online (AJOL)

    This paper aims to explore the strategies applied during the translation of chosen passages from the original Sesotho text of Chaka by Thomas Mofolo into English. Insights expressed here originate from participation in the translation workshops during the conference on “Translating Mofolo”. Different stages of the ...

  12. Thomas Aquinas: On Law, Tyranny and Resistance | Swartz | Acta ...

    African Journals Online (AJOL)

    Thomas Aquinas's notion on law, tyranny and resistance served as a limitation on governmental powers. When those who bear the law command things which exceed the competence of such authority, the subject is free to obey or disobey. The function of the law culminates in two maxims: quantum ad vim coactivam legis ...

  13. The Fallacies of Flatness: Thomas Friedman's "The World Is Flat"

    Science.gov (United States)

    Abowitz, Kathleen Knight; Roberts, Jay

    2007-01-01

    Thomas Friedman's best-selling "The World is Flat" has exerted much influence in the west by providing both an accessible analysis of globalization and its economic and social effects, and a powerful cultural metaphor for globalization. In this review, we more closely examine Friedman's notion of the social contract, the moral center of his…

  14. Cross tissue trait-pathway network reveals the importance of oxidative stress and inflammation pathways in obesity-induced diabetes in mouse.

    Directory of Open Access Journals (Sweden)

    Shouguo Gao

    Full Text Available Complex disorders often involve dysfunctions in multiple tissue organs. Elucidating the communication among them is important to understanding disease pathophysiology. In this study we integrate multiple tissue gene expression and quantitative trait measurements of an obesity-induced diabetes mouse model, with databases of molecular interaction networks, to construct a cross tissue trait-pathway network. The animals belong to two strains of mice (BTBR or B6, of two obesity status (obese or lean, and at two different ages (4 weeks and 10 weeks. Only 10 week obese BTBR animals are diabetic. The expression data was first utilized to determine the state of every pathway in each tissue, which is subsequently utilized to construct a pathway co-expression network and to define trait-relevant and trait-linking pathways. Among the six tissues profiled, the adipose contains the largest number of trait-linking pathways. Among the eight traits measured, the body weight and plasma insulin level possess the most number of relevant and linking pathways. Topological analysis of the trait-pathway network revealed that the glycolysis/gluconeogenesis pathway in liver and the insulin signaling pathway in muscle are of top importance to the information flow in the network, with the highest degrees and betweenness centralities. Interestingly, pathways related to metabolism and oxidative stress actively interact with many other pathways in all animals, whereas, among the 10 week animals, the inflammation pathways were preferentially interactive in the diabetic ones only. In summary, our method offers a systems approach to delineate disease trait relevant intra- and cross tissue pathway interactions, and provides insights to the molecular basis of the obesity-induced diabetes.

  15. 78 FR 59955 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2013-09-30

    ... National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA; Correction AGENCY: National Park Service, Interior. ACTION: Notice; correction. SUMMARY: The Thomas Burke Memorial Washington State Museum, University of Washington (Burke...

  16. Oceanographic profile data collected from CTD and sound velocimeter - moving vessel profiler casts aboard NOAA Ship THOMAS JEFFERSON, NOAA Ship Thomas Jefferson Launch 3101 and NOAA Ship Thomas Jefferson Launch 3102 as part of project OPR-D302-TJ-15 in the North Atlantic Ocean from 2015-12-03 to 2015-12-17 (NCEI Accession 0148757)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0148757 includes physical and profile data collected aboard NOAA Ship THOMAS JEFFERSON, NOAA Ship Thomas Jefferson Launch 3101 and NOAA Ship Thomas...

  17. Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling.

    Science.gov (United States)

    Struzyna, Laura A; Adewole, Dayo O; Gordián-Vélez, Wisberty J; Grovola, Michael R; Burrell, Justin C; Katiyar, Kritika S; Petrov, Dmitriy; Harris, James P; Cullen, D Kacy

    2017-05-31

    Functional recovery rarely occurs following injury or disease-induced degeneration within the central nervous system (CNS) due to the inhibitory environment and the limited capacity for neurogenesis. We are developing a strategy to simultaneously address neuronal and axonal pathway loss within the damaged CNS. This manuscript presents the fabrication protocol for micro-tissue engineered neural networks (micro-TENNs), implantable constructs consisting of neurons and aligned axonal tracts spanning the extracellular matrix (ECM) lumen of a preformed hydrogel cylinder hundreds of microns in diameter that may extend centimeters in length. Neuronal aggregates are delimited to the extremes of the three-dimensional encasement and are spanned by axonal projections. Micro-TENNs are uniquely poised as a strategy for CNS reconstruction, emulating aspects of brain connectome cytoarchitecture and potentially providing means for network replacement. The neuronal aggregates may synapse with host tissue to form new functional relays to restore and/or modulate missing or damaged circuitry. These constructs may also act as pro-regenerative "living scaffolds" capable of exploiting developmental mechanisms for cell migration and axonal pathfinding, providing synergistic structural and soluble cues based on the state of regeneration. Micro-TENNs are fabricated by pouring liquid hydrogel into a cylindrical mold containing a longitudinally centered needle. Once the hydrogel has gelled, the needle is removed, leaving a hollow micro-column. An ECM solution is added to the lumen to provide an environment suitable for neuronal adhesion and axonal outgrowth. Dissociated neurons are mechanically aggregated for precise seeding within one or both ends of the micro-column. This methodology reliably produces self-contained miniature constructs with long-projecting axonal tracts that may recapitulate features of brain neuroanatomy. Synaptic immunolabeling and genetically encoded calcium

  18. An approach for tissue density classification in mammographic images using artificial neural network based on wavelet and curvelet transforms

    Science.gov (United States)

    Yaşar, Hüseyin; Ceylan, Murat

    2015-03-01

    Breast cancer is one of the types of cancer which is most commonly seen in women. Density of breast is an important indicator for the risk of cancer. In addition, densities of tissue may harden the diagnosis by hiding the abnormalities occurring on the breast. For this reason, during the process of diagnosis, the process of automatic classification of breast density has a significant importance. In this study, a new system with the base of Artificial Neural Network (ANN) and multiple resolution analysis is suggested. Wavelet and curvelet analyses having the most common use have been used as multi resolution analysis. 4 pieces of statistics which are minimum value, maximum value, mean value and standard deviation have been extracted from the images which have been eluted to their sub-bands via multi resolution analysis. For the purpose of testing the success of the system, 322 pieces of images which are in MIAS database have been used. The obtained results for different backgrounds are so satisfying; and the highest classification values have been obtained as 97.16 % with Wavelet transform and ANN for fatty background and 79.80 % with Wavelet transform and ANN for fatty-glanduar background. The same results have been obtained using Wavelet transform and ANN and Curvelet transform and ANN for dense background and accuracy rate of 84.82 % have been reached. The results of mean classification have been obtained, for three pieces of tissue types (fatty, fatty-glanduar, dense), in sequence as 84.47 % with the use of ANN, 85.71 % with the use of curvelet analysis and ANN; and 87.26 % with the use of wavelet analysis and ANN.

  19. Developmental engineering: a new paradigm for the design and manufacturing of cell-based products. Part II: from genes to networks: tissue engineering from the viewpoint of systems biology and network science.

    Science.gov (United States)

    Lenas, Petros; Moos, Malcolm; Luyten, Frank P

    2009-12-01

    The field of tissue engineering is moving toward a new concept of "in vitro biomimetics of in vivo tissue development." In Part I of this series, we proposed a theoretical framework integrating the concepts of developmental biology with those of process design to provide the rules for the design of biomimetic processes. We named this methodology "developmental engineering" to emphasize that it is not the tissue but the process of in vitro tissue development that has to be engineered. To formulate the process design rules in a rigorous way that will allow a computational design, we should refer to mathematical methods to model the biological process taking place in vitro. Tissue functions cannot be attributed to individual molecules but rather to complex interactions between the numerous components of a cell and interactions between cells in a tissue that form a network. For tissue engineering to advance to the level of a technologically driven discipline amenable to well-established principles of process engineering, a scientifically rigorous formulation is needed of the general design rules so that the behavior of networks of genes, proteins, or cells that govern the unfolding of developmental processes could be related to the design parameters. Now that sufficient experimental data exist to construct plausible mathematical models of many biological control circuits, explicit hypotheses can be evaluated using computational approaches to facilitate process design. Recent progress in systems biology has shown that the empirical concepts of developmental biology that we used in Part I to extract the rules of biomimetic process design can be expressed in rigorous mathematical terms. This allows the accurate characterization of manufacturing processes in tissue engineering as well as the properties of the artificial tissues themselves. In addition, network science has recently shown that the behavior of biological networks strongly depends on their topology and has

  20. Relativistic transformation of the frequency of Thomas precession

    Science.gov (United States)

    Kholmetskii, A. L.; Yarman, T.

    2017-09-01

    We analyze the relativistic transformation of the frequency of the Thomas precession and show that the known expression for this frequency, written for two different inertial observers, disagrees with the Doppler expression for the signal frequency fixed by these observers. We show that this paradox is inherently related to the known Bacry paradox, and both of them are resolved via the statement that the velocity parameter, entering into the expression for the frequency of the Thomas precession, always corresponds to a rotation-free Lorentz transformation between a set of rest frames of a particle with spin, moving along a curved path, and an inertial frame of observation. Some implications of this result are discussed.

  1. Thomas Hirschhorn, l’art et l’espace public.

    Directory of Open Access Journals (Sweden)

    Emmanuelle Cherel

    2007-04-01

    Full Text Available Ce catalogue relate la manière dont l’artiste Thomas Hirschhorn est intervenu dans le quartier du Landy à Aubervilliers pour réaliser un projet de sculpture dans l’espace public. Entre avril et juin 2004 s’est ouvert, rue Albinet sous l’impulsion conjuguée de Thomas Hirschhorn et des laboratoires d’Aubervilliers, un musée inhabituel, dont la vocation fut de « faire exister l’art au-delà des espaces qui lui sont consacrés ». Ce musée prit d’autant plus de poids pour ...

  2. Losing Thomas & Ella: A Father's Story (A Research Comic).

    Science.gov (United States)

    Weaver-Hightower, Marcus B

    2017-09-01

    "Losing Thomas & Ella" presents a research comic about one father's perinatal loss of twins. The comic recounts Paul's experience of the hospital and the babies' deaths, and it details the complex grieving process afterward, including themes of anger, distance, relationship stress, self-blame, religious challenges, and resignation. A methodological appendix explains the process of constructing the comic and provides a rationale for the use of comics-based research for illness, death, and grief among practitioners, policy makers, and the bereaved.

  3. Maintaining Royal Absolutism in Thomas Middleton's A Game at Chess

    OpenAIRE

    石橋, 敬太郎; Keitaro, ISHIBASHI; 岩手県立大学盛岡短期大学部

    2004-01-01

    At the time when Thomas Middleton was composing A Game at Chess, King James I's reliance upon Count Gondomar, the former Spanish Ambassador, made clear that the King had envisioned arranging a Catholic marriage for his heir and securing the restitution of the Palatine through the Spanish advice. But James's inability to recognize that his policy had become a real threat to the commonweal prompted his Parliament to make war against Spain. Despite conternporaries' perception of it as a politica...

  4. Thomas Kuhn e a nova historiografia da ciência

    Directory of Open Access Journals (Sweden)

    Bernardo Jefferson de Oliveira

    2002-01-01

    Full Text Available This article tries to show the Thomas Kuhn's critics to some conceptions of the contemporary historiography of science that became radical many of the positions formulated initially by Kuhn himself. It is still intended to show that the new orientation of Kuhn, starting from his critic to his successors, approaches him more of his initial influences, especially, Ludwig Wittgenstein and Ludwik Fleck.

  5. Thomas Alva Edison (170th Anniversary of His Birth)

    OpenAIRE

    V. P. Samokhin; E A. Tikhomirovа

    2017-01-01

    A brief overview of the major technical achievements of Thomas Edison, an outstanding American inventor, author of more than 1,000 US patents and several thousand patents in other countries, honorary academician of the USSR. Presents biographical information and details of the formation of Edison, his work as a telegrapher, organizing the world's first industrial research laboratory for the continuous development of technological innovations, as well as some interesting facts about his life a...

  6. Extended Thomas-Fermi expansion from nuclear linear response

    Energy Technology Data Exchange (ETDEWEB)

    Navarro, J. [IFIC, Centre Mixt CSIC, Universitat de Valencia, Avda Dr Moliner 50, E-46.100 Burjassot (Spain); Vinas, X. [Departamento Estructura i Constituents de la Materia, Facultat de Fisica, Universitat de Barcelona, Diagonal 645, E-08028 Barcelona (Spain)

    1996-09-01

    The coefficients of the successive h/2{pi}{sup 2} orders of the extended Thomas-Fermi expansion of the kinetic energy density are obtained to the leading order in the density inhomogeneities. This is done by comparing the corresponding static polarizability with the exact value in two cases: a non-interacting nuclear infinite system and symmetric nuclear matter with a Skyrme interaction. (author)

  7. Relativistic extended Thomas-Fermi calculations of finite nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Centelles, M.; Vinas, X.; Barranco, M. (Barcelona Univ. (Spain). Facultat de Fisica); Ohtsuka, N.; Faessler, Amand; Khoa, D.T.; Muether, H. (Tuebingen Univ. (Germany). Inst. fuer Theoretische Physik)

    1991-11-01

    We have used for the first time a relativistic extended Thomas-Fermi method which includes up to (h/2{pi}){sup 2}-corrective terms to study the structure of finite nuclei. The potential part has been obtained from a local density approximation to Dirac-Brueckner calculations carried out with a realistic nucleon-nucleon potential. Some applications to fission barriers and optical potentials for heavy ion scattering are presented. (author).

  8. Label-free LC-MSe in tissue and serum reveals protein networks underlying differences between benign and malignant serous ovarian tumors.

    Directory of Open Access Journals (Sweden)

    Wouter Wegdam

    Full Text Available PURPOSE: To identify proteins and (molecular/biological pathways associated with differences between benign and malignant epithelial ovarian tumors. EXPERIMENTAL PROCEDURES: Serum of six patients with a serous adenocarcinoma of the ovary was collected before treatment, with a control group consisting of six matched patients with a serous cystadenoma. In addition to the serum, homogeneous regions of cells exhibiting uniform histology were isolated from benign and cancerous tissue by laser microdissection. We subsequently employed label-free liquid chromatography tandem mass spectrometry (LC-MSe to identify proteins in these serum and tissues samples. Analyses of differential expression between samples were performed using Bioconductor packages and in-house scripts in the statistical software package R. Hierarchical clustering and pathway enrichment analyses were performed, as well as network enrichment and interactome analysis using MetaCore. RESULTS: In total, we identified 20 and 71 proteins that were significantly differentially expressed between benign and malignant serum and tissue samples, respectively. The differentially expressed protein sets in serum and tissue largely differed with only 2 proteins in common. MetaCore network analysis, however inferred GCR-alpha and Sp1 as common transcriptional regulators. Interactome analysis highlighted 14-3-3 zeta/delta, 14-3-3 beta/alpha, Alpha-actinin 4, HSP60, and PCBP1 as critical proteins in the tumor proteome signature based on their relative overconnectivity. The data have been deposited to the ProteomeXchange with identifier PXD001084. DISCUSSION: Our analysis identified proteins with both novel and previously known associations to ovarian cancer biology. Despite the small overlap between differentially expressed protein sets in serum and tissue, APOA1 and Serotransferrin were significantly lower expressed in both serum and cancer tissue samples, suggesting a tissue-derived effect in serum

  9. Knowledge Society and the flat World of Thomas L. Friedman

    Directory of Open Access Journals (Sweden)

    Dana Ramona ANDRISESCU

    2008-01-01

    Full Text Available The traditional society became lately the knowledge society. As the name states, knowledge is the most important asset of our times. There are different opinions on knowledge society and on globalization, but we will deal in this paper with Thomas Friedman’s flat world. The world got smaller with the developments in information and communication technology. Globalization has three periods and ten flatteners widely described by Friedman in his book. Technology changes the way we communicate, collaborate and share our knowledge.

  10. Nom comú i nom propi segons Thomas Hobbes

    Directory of Open Access Journals (Sweden)

    Josep Moran i Ocerinjauregui

    2014-01-01

    Full Text Available Thomas Hobbes (1588-1679 tracta el llenguatge humà, i més concretament els noms, des d’un punt de vista filosòfic. Per a Hobbes, els noms són designadors de conceptes: els noms propis designen una sola cosa mentre que els noms comuns en designen diverses. Aquestes idees van ser objecte de reflexió filosòfica i van tenir gran influència en altres filòsofs, com John Stuart Mill.

  11. Thomas Carlyle and the making of Frederick the Great

    OpenAIRE

    Stewart, Linda Clark

    2010-01-01

    Thomas Carlyle’s History of Friedrich II. of Prussia, called Frederick the Great was published in six volumes between 1858 and 1865 and was his last major work. Carlyle had a specific purpose in mind when he began writing Frederick. He believed that contemporary events had left Europe in disarray and the British nation fragmented. In his view, the nation needed to function as a family unit, with the older, more experienced members of the group instructing and educating the young. Carlyle’s at...

  12. Self-consistent extended Thomas-Fermi calculations in nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Centelles, M.; Pi, M.; Vinas, X. (Barcelona Univ. (Spain). Facultad de Fisica); Garcias, F.; Barranco, M. (Universidad de las Islas Baleares, Ciudad de Mallorca (Spain). Dept. de Fisica)

    1990-04-16

    We have solved the Euler-Lagrange (EL) equations corresponding to the {Dirac h}{sup 4}-order extended Thomas-Fermi model for external potentials and nuclear forces of Skyrme type. We analyze in detail the {Dirac h}{sup 2}- and {Dirac h}{sup 4}-order contributions of the non-local terms arising from the nucleon effective mass and the spin-orbit force. Our results are compared with others obtained using different semiclassical methods. Some useful approximations to the exact {Dirac h}{sup 4} EL equations are proposed in the case of general Skyrme forces. (orig.).

  13. Stefan Lang, Thomas Blaschke: Landscape Analysis with GIS

    Directory of Open Access Journals (Sweden)

    Nedjeljko Frančula

    2010-12-01

    Full Text Available The book Landscape Analysis with GIS by Stefan Lang and Thomas Blaschke is a translation of the German original Landschaftsanalyse mit GIS published in 2007. The book has been translated from German to Croatian by Tatjana Bekavac Bahorić. The Croatian edition editor has been Dr. Danko Marinković, the reviewers Assist. Prof. Vlado Cetl and Dr. Hrvoje Matijević, and the publisher – ITD Gaudeamus d.o.o. from Požega. The book was published in 2010, supported by the Croatian Ministry of Science, Education and Sports, and under the auspices of the Croatian Chamber of Licensed Geodesy Engineers.

  14. SOME ASPECTS OF CONTEMPORARY ATHEISM AND ST. THOMAS AQUINA

    Directory of Open Access Journals (Sweden)

    CH. MOREROD

    2010-10-01

    Full Text Available Atheism has become fashionable in the recent years. It has diff erent forms, but in many cases starts from the presupposition that the only rational approach is the one of natural sciences. Believers have the duty to provide some answers to the atheists, also at the philosophical level. St. Thomas Aquinas off ers several arguments that can be explained in contemporary terms: the Universe needs a fi rst cause, which acts also through created causes; our desire for the infi nite is a sign of God; the order of the Universe suggests and organizer

  15. Avi Sorting Network

    OpenAIRE

    Avinash Bansal; Kamal Gupta

    2012-01-01

    Sorting network is an abstract mathematical modelwhich can be used as a multiple-input, multiple-output switchingnetwork to sort the data in ascending or descending order [1].Sorting has been one of the most critical applications on parallelcomputing machines. Many classic textbooks on algorithms likeThomas H. Cormen, therefore consider this problem in greatdetail and list many sorting network for this purpose [2]. Thereare many sorting algorithms as the Bubble / Insertion sorter,Odd-Even sor...

  16. Primary Mucosa-Associated Lymphoid Tissue Lymphoma of the Salivary Glands: A Multicenter Rare Cancer Network Study

    Energy Technology Data Exchange (ETDEWEB)

    Anacak, Yavuz, E-mail: yavuz.anacak@ege.edu.tr [Department of Radiation Oncology, Ege University Medical School, Izmir (Turkey); Miller, Robert C. [Department of Radiation Oncology, Mayo Clinic, Rochester, MN (United States); Constantinou, Nikos [Department of Hematology, Theagenion Cancer Center, Thessaloniki (Greece); Mamusa, Angela M. [Division of Hematology, Armando Businco Cancer Center, Cagliari (Italy); Epelbaum, Ron [Department of Oncology, Rambam Medical Center, Haifa (Israel); Li Yexiong [Department of Radiation Oncology, Cancer Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China); Calduch, Anna Lucas [Servicio de Oncologia Radioterapica, Institut Catala d' Oncologia, Barcelona (Spain); Kowalczyk, Anna [Department of Oncology and Radiotherapy, Medical University of Gdansk (Poland); Weber, Damien C. [Department of Radiation Oncology, Geneva University Hospital (Switzerland); Kadish, Sidney P. [Department of Radiation Oncology, University of Massachusetts Medical School/Center, North Worcester, MA (United States); Bese, Nuran [Department of Radiation Oncology, Istanbul University Cerrahpasa Medical School, Istanbul (Turkey); Poortmans, Philip [Institute Verbeeten, Tilburg (Netherlands); Kamer, Serra [Department of Radiation Oncology, Ege University Medical School, Izmir (Turkey); Ozsahin, Mahmut [Department of Radiation Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne (Switzerland)

    2012-01-01

    Purpose: Involvement of salivary glands with mucosa-associated lymphoid tissue (MALT) lymphoma is rare. This retrospective study was performed to assess the clinical profile, treatment outcome, and prognostic factors of MALT lymphoma of the salivary glands. Methods and Materials: Thirteen member centers of the Rare Cancer Network from 10 countries participated, providing data on 63 patients. The median age was 58 years; 47 patients were female and 16 were male. The parotid glands were involved in 49 cases, submandibular in 15, and minor glands in 3. Multiple glands were involved in 9 patients. Staging was as follows: IE in 34, IIE in 12, IIIE in 2, and IV in 15 patients. Results: Surgery (S) alone was performed in 9, radiotherapy (RT) alone in 8, and chemotherapy (CT) alone in 4 patients. Forty-one patients received combined modality treatment (S + RT in 23, S + CT in 8, RT + CT in 4, and all three modalities in 6 patients). No active treatment was given in one case. After initial treatment there was no tumor in 57 patients and residual tumor in 5. Tumor progression was observed in 23 (36.5%) (local in 1, other salivary glands in 10, lymph nodes in 11, and elsewhere in 6). Five patients died of disease progression and the other 5 of other causes. The 5-year disease-free survival, disease-specific survival, and overall survival were 54.4%, 93.2%, and 81.7%, respectively. Factors influencing disease-free survival were use of RT, stage, and residual tumor (p < 0.01). Factors influencing disease-specific survival were stage, recurrence, and residual tumor (p < 0.01). Conclusions: To our knowledge, this report represents the largest series of MALT lymphomas of the salivary glands published to date. This disease may involve all salivary glands either initially or subsequently in 30% of patients. Recurrences may occur in up to 35% of patients at 5 years; however, survival is not affected. Radiotherapy is the only treatment modality that improves disease-free survival.

  17. Told by a myth: Thomas Mann’s Felix Krull

    Directory of Open Access Journals (Sweden)

    Montiel, Luis

    2013-12-01

    Full Text Available This article proposes an approach to the novel Bekenntnisse des Hochstaplers Felix Krull by Thomas Mann from the point of view of the imaginal psychology of James Hillman. From this perspective the novel seems to illustrate the most innovative thesis of that psychology, which is especially relevant for having been written prior to the formulation of Hillman’s theories. The unplanned correspondence between both ways of thinking furnishes a valuable argument that supports the new conception of human psyche introduced by Carl Gustav Jung and developed in this way by James Hillman.El presente artículo propone una lectura de la novela de Thomas Mann desde la óptica de la psicología imaginal de James Hillman. En esta perspectiva la novela parece ofrecer una ilustración de las tesis más innovadoras de dicha psicología, lo que resulta especialmente relevante por haber sido escrita con antelación a la formulación de las teorías del pensador estadounidense. La impremeditada correspondencia entre ambos pensamientos suministra un argumento digno de tenerse en cuenta a favor de la innovadora concepción de la psique humana inaugurada por Carl Gustav Jung y desarrollada en esta línea por James Hillman.

  18. Paradigms in epidemiology textbooks: in the footsteps of Thomas Kuhn.

    Science.gov (United States)

    Bhopal, R

    1999-01-01

    This article attempts to contribute to the debate on the future of epidemiology by combining Thomas Kuhn's ideas on scientific paradigms with the author's observations on some epidemiology textbooks. The author's interpretations were based on his readings of Kuhn's The Structure of Scientific Revolutions, epidemiology textbooks, and papers on the future of epidemiology. Thomas Kuhn's view is that sciences mostly work with a single paradigm driven by exemplars of successful work, and that proposals for paradigm change are resisted. Sciences that are maturing or changing do not have a dominant paradigm. Epidemiology textbooks showed diversity in their concepts, content, and approach. Most exemplars related to etiologic research rather than public health practice. One key focus of the recent controversy regarding the role of epidemiology has been the increasing inability of epidemiology to solve socially based public health problems. Kuhn's views help explain the polarization of views expressed. Kuhn's philosophy of science offers insights into controversies such as whether a paradigm shift is needed or imminent and the gap between epidemiology and public health practice. Interaction between science philosophers, epidemiologists, and public health practitioners may be valuable. PMID:10432899

  19. Instantons, quivers and noncommutative Donaldson-Thomas theory

    Energy Technology Data Exchange (ETDEWEB)

    Cirafici, Michele, E-mail: cirafici@math.ist.utl.pt [Centro de Analise Matematica, Geometria e Sistemas Dinamicos, Departamento de Matematica, Instituto Superior Tecnico, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Sinkovics, Annamaria, E-mail: A.Sinkovics@damtp.cam.ac.uk [Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA (United Kingdom); Szabo, Richard J., E-mail: R.J.Szabo@ma.hw.ac.uk [Department of Mathematics, Heriot-Watt University, Colin Maclaurin Building, Riccarton, Edinburgh EH14 4AS (United Kingdom); Maxwell Institute for Mathematical Sciences, Edinburgh (United Kingdom)

    2011-12-11

    We construct noncommutative Donaldson-Thomas invariants associated with abelian orbifold singularities by analyzing the instanton contributions to a six-dimensional topological gauge theory. The noncommutative deformation of this gauge theory localizes on noncommutative instantons which can be classified in terms of three-dimensional Young diagrams with a colouring of boxes according to the orbifold group. We construct a moduli space for these gauge field configurations which allows us to compute its virtual numbers via the counting of representations of a quiver with relations. The quiver encodes the instanton dynamics of the noncommutative gauge theory, and is associated to the geometry of the singularity via the generalized McKay correspondence. The index of BPS states which compute the noncommutative Donaldson-Thomas invariants is realized via topological quantum mechanics based on the quiver data. We illustrate these constructions with several explicit examples, involving also higher rank Coulomb branch invariants and geometries with compact divisors, and connect our approach with other ones in the literature.

  20. Vigencia de algunas de las ideas mercantilistas de Thomas Mun

    Directory of Open Access Journals (Sweden)

    Emmanuel Borgucci

    2011-01-01

    Full Text Available Generalmente cuando se aborda el mercantilismo se hace referencia a la acumulación de oro y plata, una balanza de pagos favorable o a la política económica de Jean Colbert. Pero poco se ha hablado del papel y condiciones necesarias del comerciante como agente que hizo posible que los primeros Estados-Nación se convirtieran en las futuras potencias económicas del mundo occidental. Thomas Mun fue uno de aquellos escritores mercantilistas que destacó el papel del comerciante en el auge del sistema mercantilista. El estudio de sus ideas permite concluir que sus recomendaciones acerca de lo que debería ser un comerciante de éxito siguen vigentes hoy en día. La razón de tal afirmación estriba en que sus recomendaciones eran adecuadas en un marco en que se estaba presentando una transformación significativa del sistema de organización comercial con la presencia de la Joint-Stock Company. Independientemente de que muchas de las funciones que Thomas Mun le atribuía al comerciante hoy en día son especializadas, su dominio sigue siendo la clave del éxito de una política comercial que emprenda cualquier nación.

  1. Philosophical Creationism: Thomas Aquinas’ Metaphysics of Creatio ex Nihilo

    Directory of Open Access Journals (Sweden)

    Andrzej Maryniarczyk

    2016-03-01

    Full Text Available All philosophers, beginning with the pre-Socratics, through Plato and Aristotle, and up to Thomas Aquinas, accepted as a certain that the world as a whole existed eternally. The foundation for the eternity of the world was the indestructible and eternal primal building material of the world, a material that existed in the form of primordial material elements (the Ionians, in the form of ideas (Plato, or in the form of matter, eternal motion, and the first heavens (Aristotle. The article outlines the main structure of the philosophical theory of creation ex nihilo developed by St. Thomas Aquinas and indebted to his metaphysical thought. It shows the wisdom-based and ratiocinative foundation of the rational cognition of reality—reality that comes from the personal creative act of God. It concludes that the perception that the beings called to existence by the personal act of God the Creator are intelligible is the ultimate rational justification for the fact that our human cognition, love, and spiritual creativity are rational.

  2. Multi-tissue analysis of co-expression networks by higher-order generalized singular value decomposition identifies functionally coherent transcriptional modules.

    Science.gov (United States)

    Xiao, Xiaolin; Moreno-Moral, Aida; Rotival, Maxime; Bottolo, Leonardo; Petretto, Enrico

    2014-01-01

    Recent high-throughput efforts such as ENCODE have generated a large body of genome-scale transcriptional data in multiple conditions (e.g., cell-types and disease states). Leveraging these data is especially important for network-based approaches to human disease, for instance to identify coherent transcriptional modules (subnetworks) that can inform functional disease mechanisms and pathological pathways. Yet, genome-scale network analysis across conditions is significantly hampered by the paucity of robust and computationally-efficient methods. Building on the Higher-Order Generalized Singular Value Decomposition, we introduce a new algorithmic approach for efficient, parameter-free and reproducible identification of network-modules simultaneously across multiple conditions. Our method can accommodate weighted (and unweighted) networks of any size and can similarly use co-expression or raw gene expression input data, without hinging upon the definition and stability of the correlation used to assess gene co-expression. In simulation studies, we demonstrated distinctive advantages of our method over existing methods, which was able to recover accurately both common and condition-specific network-modules without entailing ad-hoc input parameters as required by other approaches. We applied our method to genome-scale and multi-tissue transcriptomic datasets from rats (microarray-based) and humans (mRNA-sequencing-based) and identified several common and tissue-specific subnetworks with functional significance, which were not detected by other methods. In humans we recapitulated the crosstalk between cell-cycle progression and cell-extracellular matrix interactions processes in ventricular zones during neocortex expansion and further, we uncovered pathways related to development of later cognitive functions in the cortical plate of the developing brain which were previously unappreciated. Analyses of seven rat tissues identified a multi-tissue subnetwork of co

  3. Multi-tissue analysis of co-expression networks by higher-order generalized singular value decomposition identifies functionally coherent transcriptional modules.

    Directory of Open Access Journals (Sweden)

    Xiaolin Xiao

    2014-01-01

    Full Text Available Recent high-throughput efforts such as ENCODE have generated a large body of genome-scale transcriptional data in multiple conditions (e.g., cell-types and disease states. Leveraging these data is especially important for network-based approaches to human disease, for instance to identify coherent transcriptional modules (subnetworks that can inform functional disease mechanisms and pathological pathways. Yet, genome-scale network analysis across conditions is significantly hampered by the paucity of robust and computationally-efficient methods. Building on the Higher-Order Generalized Singular Value Decomposition, we introduce a new algorithmic approach for efficient, parameter-free and reproducible identification of network-modules simultaneously across multiple conditions. Our method can accommodate weighted (and unweighted networks of any size and can similarly use co-expression or raw gene expression input data, without hinging upon the definition and stability of the correlation used to assess gene co-expression. In simulation studies, we demonstrated distinctive advantages of our method over existing methods, which was able to recover accurately both common and condition-specific network-modules without entailing ad-hoc input parameters as required by other approaches. We applied our method to genome-scale and multi-tissue transcriptomic datasets from rats (microarray-based and humans (mRNA-sequencing-based and identified several common and tissue-specific subnetworks with functional significance, which were not detected by other methods. In humans we recapitulated the crosstalk between cell-cycle progression and cell-extracellular matrix interactions processes in ventricular zones during neocortex expansion and further, we uncovered pathways related to development of later cognitive functions in the cortical plate of the developing brain which were previously unappreciated. Analyses of seven rat tissues identified a multi-tissue

  4. Gene expression profile of the cartilage tissue spontaneously regenerated in vivo by using a novel double-network gel: Comparisons with the normal articular cartilage

    Directory of Open Access Journals (Sweden)

    Kurokawa Takayuki

    2011-09-01

    Full Text Available Abstract Background We have recently found a phenomenon that spontaneous regeneration of a hyaline cartilage-like tissue can be induced in a large osteochondral defect by implanting a double-network (DN hydrogel plug, which was composed of poly-(2-Acrylamido-2-methylpropanesulfonic acid and poly-(N, N'-Dimetyl acrylamide, at the bottom of the defect. The purpose of this study was to clarify gene expression profile of the regenerated tissue in comparison with that of the normal articular cartilage. Methods We created a cylindrical osteochondral defect in the rabbit femoral grooves. Then, we implanted the DN gel plug at the bottom of the defect. At 2 and 4 weeks after surgery, the regenerated tissue was analyzed using DNA microarray and immunohistochemical examinations. Results The gene expression profiles of the regenerated tissues were macroscopically similar to the normal cartilage, but showed some minor differences. The expression degree of COL2A1, COL1A2, COL10A1, DCN, FMOD, SPARC, FLOD2, CHAD, CTGF, and COMP genes was greater in the regenerated tissue than in the normal cartilage. The top 30 genes that expressed 5 times or more in the regenerated tissue as compared with the normal cartilage included type-2 collagen, type-10 collagen, FN, vimentin, COMP, EF1alpha, TFCP2, and GAPDH genes. Conclusions The tissue regenerated by using the DN gel was genetically similar but not completely identical to articular cartilage. The genetic data shown in this study are useful for future studies to identify specific genes involved in spontaneous cartilage regeneration.

  5. Organ and Tissue-specific Sucrose Transporters. Important Hubs in Gene and Metabolite Networks Regulating Carbon Use in Wood-forming Tissues of Populus

    Energy Technology Data Exchange (ETDEWEB)

    Harding, Scott A. [Univ. of Georgia, Athens, GA (United States); Tsai, Chung-Jui [Univ. of Georgia, Athens, GA (United States)

    2016-01-04

    The overall project objective was to probe the relationship between sucrose transporters and plant productivity in the biomass for biofuels woody perennial, Populus. At the time the proposal was written, sucrose transporters had already been investigated in many plant model systems, primarily with respect to the export of photosynthate sucrose from source leaves, and the uptake of sucrose in storage organs and seeds. Preliminary findings by the PI found that in Populus, sucrose transporter genes (SUTs) were well expressed in wood-forming tissues that comprise the feedstock for biofuels production. Because sucrose comprises by far the predominant form in which photosynthate is delivered from source organs to sink organs like roots and wood-forming tissues, SUTs control a gate that nominally at least could impact the allocation or partitioning of sucrose for potentially competing end uses like growth (stem biomass) and storage. In addition, water use might be conditioned by the way in which sucrose is distributed throughout the plant, and/or by the way in which sucrose is partitioned intracellularly. Several dozen transgenic lines were produced in year 1 of the project to perturb the expression ratio of multiple plasma membrane (PM) SUTs (intercellular trafficking), versus the single tonoplast membrane (TM) sucrose transporter that effectively regulates intracellular trafficking of sucrose. It was possible to obtain transgenic lines with dual SUT gene knockdown using the 35S promoter, but not the wood-specific TUA1 promoter. By the end of project year 2, a decision was made to work with the 35S plants while archiving the TUA1 plants. The PhD candidate charged with producing the transgenic lines abandoned the project during its second year, substantially contributing to the decision to operate with just the 35S lines. That student’s interests ranged more toward evolutionary topics, and a report on SUT gene evolution was published (Peng et al 2014).

  6. The correspondence of Thomas Dale (1700-1750): Botany in the transatlantic Republic of Letters.

    Science.gov (United States)

    Cook, William J

    2012-03-01

    This paper seeks to provide a full account of the life and career of Dr. Thomas Dale (1700-1750), with particular reference to his botanical works and correspondence. Born in Hoxton, London, Dale studied medicine at Leiden and engaged fully in the social, literary and epistolary network in which botany was practised in eighteenth-century England. In 1730, however, Dale relocated to the British colonial port of Charles Town, South Carolina. Here he continued to engage in a transatlantic network of botanical exchange and discussion, corresponding on equal and reciprocal terms with his former colleagues in England. Where Dale differs from naturalists in South Carolina before him is that his motives for pursuing botany and for corresponding with English naturalists were located firmly in the New World. Such a conclusion forms a valuable, albeit small contribution to models for the development of national scientific cultures in the imperial world. Similarly, Dale's pursuit of botanical information in South Carolina provides a small amount of material with which to illustrate currently fashionable models for the mediated exchange and circulation of scientific knowledge. Copyright © 2011 Elsevier Ltd. All rights reserved.

  7. Thomas Hobbes: la resistencia política al Leviatán || Thomas Hobbes: Political Resistance To Leviathan

    Directory of Open Access Journals (Sweden)

    Diego Alejandro Fernández Peychaux

    2013-12-01

    Full Text Available RESUMEN En el presente artículo se presentan cuatro claves de lectura de la obra de Thomas Hobbes desde las que fundamentar una noción de resistencia. Este aporte busca, en otras palabras, crear las condiciones de posibilidad de un debate filosófico ofuscado por el mito recurrente sobre el supuesto monstruo de Malmesbury. Una vez hecho esto, se propone delinear las bases de un enfoque metodológico que parta de dicha noción de resistencia. De ese modo, se fundamentaría el primer paso hacia una apropiación ?o expropiación? contemporánea de la matriz hobbesiana de la relación obediencia-seguridad   ABSTRACT This article presents four key of readings about Thomas Hobbes's work, from which it supports a particular notion of resistance. In others words, this contribution searches to create the conditions of posibility for a philosophical debate obfuscated by the recurrent myth about the monster of Malmesbury. Once done that, I offer setting the bases of a metodological aproach which stars from this notion of resistance. Thus, I would back the first step towards a contemporary appropriation ?or expropriation? of the obedience-security relationship within the Hobbesian matrix.  

  8. The search for the true self in the Gospel of Thomas, the Book of Thomas and the Hymn of the Pearl

    Directory of Open Access Journals (Sweden)

    Patrick J. Hartin

    1999-12-01

    Full Text Available At the heart of the Gospel of Thomas lies the call to achieve an understanding of one's self (Logia 67-70. This call focuses the struggle of Thomas Christians by turning it inward as a challenge to understand their own true identity. Through this struggle they come to a knowledge of the Father. The significance of this theme of the search for the true self is examined further in the context of the Gospel of Thomas (Logia 3; 58; 111. From this study, it emerges that Thomas Christians experienced that they were strangers in a hostile world. Feeling alienated, they wished to escape rom the world. The positive outcome of this experience was a deeper self-understanding. This study culminates in an examination of this theme of the search for one's self in two other writings at home within early Syrian Christianity. In the Hymn of the Pearl (Acts of Thomas 108-113 the theme emerges in the allegory of the soul's quest for self-knowledge. The path to salvation is a search that ultimately takes one rom the world. In the Book of Thomas the Contender the same search for one's identity is emphasised (138:15-20 and 145:1-15. Finally, it is argued that this search for one's true identity is appropriate to the historical and sociological context of the Syrian Church in Edessa.

  9. Improving access: modifying Penchansky and Thomas's Theory of Access.

    Science.gov (United States)

    Saurman, Emily

    2016-01-01

    Access is defined as the degree of fit between the user and the service; the better the fit, the better the access. Using the theory developed by Penchansky and Thomas, access is optimized by accounting for the different dimensions of access: accessibility; availability; acceptability; affordability; and adequacy in service design, implementation and evaluation. These dimensions are independent yet interconnected and each is important to assess the achievement of access. However, I argue that one dimension is missing - awareness. I propose that awareness is integral to access, that it should become a permanent part of the theory, and be applied whenever using the theory to develop, implement, or evaluate health care services and access more generally. © The Author(s) 2015.

  10. Thomas Merton: The true self and the quest for justice

    Directory of Open Access Journals (Sweden)

    Susan Rakoczy

    2016-05-01

    Full Text Available The year 2015 marked the 100th anniversary of the birth of Thomas Merton who was born on31 January 1915. His writings cover diverse themes, which are of value to a myriad of faithtraditions. This article will trace his understanding of holiness and the way in which Mertonemphasised participation in the transformation of the world. It commences with a biographicaloverview of Merton and then Merton’s understanding of ‘holiness’ as growth of the ‘true self’in God is discussed. His work as social critic is outlined and the article ends with a reflectionof Merton’s understanding of ‘love’ and ‘compassion’ – a life before God.

  11. A Tony Thomas-Inspired Guide to INSPIRE

    Energy Technology Data Exchange (ETDEWEB)

    O' Connell, Heath B.; /Fermilab

    2010-04-01

    The SPIRES database was created in the late 1960s to catalogue the high energy physics preprints received by the SLAC Library. In the early 1990s it became the first database on the web and the first website outside of Europe. Although indispensible to the HEP community, its aging software infrastructure is becoming a serious liability. In a joint project involving CERN, DESY, Fermilab and SLAC, a new database, INSPIRE, is being created to replace SPIRES using CERN's modern, open-source Invenio database software. INSPIRE will maintain the content and functionality of SPIRES plus many new features. I describe this evolution from the birth of SPIRES to the current day, noting that the career of Tony Thomas spans this timeline.

  12. Las revoluciones de Thomas Kuhn, una mirada discontinuista

    Directory of Open Access Journals (Sweden)

    Pablo Melogno

    Full Text Available Resumen Se discuten algunas divergencias entre La revolución copernicana (1957 y La estructura de las revoluciones científicas (1962, de Thomas Kuhn. Se muestra que presentan una consideración diferente de los factores extracientíficos, que tienen en la primera un peso explicativo mayor. Se propone que en 1957 Kuhn maneja una historiografía casuística, centrada en la revolución copernicana, y en 1962 una historiografía estructural, centrada en los rasgos invariantes de las revoluciones científicas. Se concluye que las diferencias entre las dos obras son lo suficientemente profundas como para no considerarlas expresión de una misma visión de la ciencia.

  13. Focus on: Thomas Jefferson University Hospital, Department of Biomedical Instrumentation.

    Science.gov (United States)

    Tackel, I S; Bell, D; Edelson, R C

    1993-01-01

    Technology management services at Thomas Jefferson University Hospital are provided by two distinct cost centers: The Department of Biomedical Instrumentation and Jefferson Biomedical Shared Services. The in-house division of the Department of Biomedical Instrumentation (BMI) provides clinical engineering services to the hospital, a 717-bed, tertiary care facility. BMI supports traditional patient care instrumentation, as well as dialysis machines, anesthesia machines, lasers, and the neonatal extracorporeal membrane oxygenation (ECMO) systems. In addition, the department supports over 3,000 personal computers and associated peripherals, and provides research, design, database support, device evaluation, incident investigation, and product problem investigation services. Jefferson Biomedical Shared Services, an integral component of the Department of Biomedical Instrumentation, offers a shared services program to local area hospitals. It has a current client list of 11 major healthcare institutions with annual revenues approaching $3,000,000 per year.

  14. Thomas Mofolo: the man, the writer and his contexts | Gill | Tydskrif ...

    African Journals Online (AJOL)

    For example, as a boy, we learn that Thomas imbibed a great deal from his father Abner Ramofolo Mofolo, a very hard-working and practically-oriented man, who was himself a gifted storyteller. Given the possibility of pursuing higher studies through the Protestant PEMS Mission, Thomas grabbed this opportunity and came ...

  15. Thomas Jefferson's Plan for the University of Virginia: Lessons from the Lawn. Teaching with Historic Places.

    Science.gov (United States)

    Hughes, Mary; Wilson, Sara

    This lesson is based on the National Register of Historic Places registration file, "University of Virginia Historic District," and other primary and secondary materials about Thomas Jefferson and the ctreation of the University of Virginia. Thomas Jefferson did not begin the effort of designing the University of Virginia…

  16. Thomas Hiärne - nimi Rootsi Läänemereprovintside varasest ajalookirjutusest / Piret Lotman

    Index Scriptorium Estoniae

    Lotman, Piret, 1950-

    2008-01-01

    Thomase isa Erlandi karjäärist. Thomas Hiärne headest suhetest Eestimaa kindralkuberneri Bengt Horniga. Thomas Hiärne kandideerimisest Ingerimaa rüütelkonna sekretäri kohale. Tema tegevusest Virtsu mõisa inspektorina. Hiärne kroonikast ja ajalookäsitlusest

  17. 78 FR 64006 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2013-10-25

    ... National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Thomas Burke Memorial Washington State Museum, University of Washington (Burke Museum), has completed an...

  18. 75 FR 36672 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2010-06-28

    ... National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA AGENCY: National Park Service, Interior. ACTION: Notice. Notice is here.... 3003, of the completion of an inventory of human remains in the possession of the Thomas Burke Memorial...

  19. 78 FR 65511 - Death of Thomas S. Foley Former Speaker of the House of Representatives

    Science.gov (United States)

    2013-10-31

    ... From the Federal Register Online via the Government Publishing Office ] Vol. 78 Thursday, No. 211 October 31, 2013 Part IV The President Proclamation 9046--Death of Thomas S. Foley Former Speaker of the... ] Proclamation 9046 of October 28, 2013 Death of Thomas S. Foley Former Speaker of the House of Representatives...

  20. 77 FR 51564 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2012-08-24

    ... National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum... Thomas Burke Memorial Washington State Museum (Burke Museum), University of Washington, has completed an... contact the Burke Museum. Repatriation of the human remains to the tribe named below may occur if no...

  1. 78 FR 11675 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2013-02-19

    ... National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum... Thomas Burke Memorial Washington State Museum (Burke Museum) has completed an inventory of human remains... believes itself to be culturally affiliated with the human remains may contact the Burke Museum...

  2. Contributions to the knowledge of Banasa Stål (Hemiptera, Heteroptera, Pentatomidae: Banasa chaca Thomas

    Directory of Open Access Journals (Sweden)

    Thereza de Almeida Garbelotto

    2011-09-01

    Full Text Available Contributions to the knowledge of Banasa Stål (Hemiptera, Heteroptera, Pentatomidae: Banasa chaca Thomas. The male of Banasa chaca Thomas is described with emphasis on external and internal genitalia and the female internal genitalia is described. Banasa chaca is newly recorded from Buenos Aires Province (Argentina.

  3. ThomAs AquinAs: on LAW, TyrAnny And resisTAnce

    African Journals Online (AJOL)

    Thomas Aquinas's notion on law, tyranny and resistance served as a limitation on gov ernmental powers. When those ... sult of and divine remedy for sin. for Thomas Aquinas, the idea of sin and its con sequences remained a .... is obliged to disobey it, as did the holy martyrs who suffered death rather than obey the impious ...

  4. Thomas Young's investigations in gradient-index optics.

    Science.gov (United States)

    Atchison, David A; Charman, W Neil

    2011-05-01

    James Clerk Maxwell is usually recognized as being the first, in 1854, to consider using inhomogeneous media in optical systems. However, some 50 years earlier, Thomas Young, stimulated by his interest in the optics of the eye and accommodation, had already modeled some applications of gradient-index optics. These applications included using an axial gradient to provide spherical aberration-free optics and a spherical gradient to describe the optics of the atmosphere and the eye lens. We evaluated Young's contributions. We attempted to derive Young's equations for axial and spherical refractive index gradients. Raytracing was used to confirm accuracy of formula. We did not confirm Young's equation for the axial gradient to provide aberration-free optics but derived a slightly different equation. We confirmed the correctness of his equations for deviation of rays in a spherical gradient index and for the focal length of a lens with a nucleus of fixed index surrounded by a cortex of reducing index toward the edge. Young claimed that the equation for focal length applied to a lens with part of the constant index nucleus of the sphere removed, such that the loss of focal length was a quarter of the thickness removed, but this is not strictly correct. Young's theoretical work in gradient-index optics received no acknowledgment from either his contemporaries or later authors. Although his model of the eye lens is not an accurate physiological description of the human lens, with the index reducing least quickly at the edge, it represented a bold attempt to approximate the characteristics of the lens. Thomas Young's work deserves wider recognition.

  5. Physical data from CTD casts in the North Pacific Ocean from the THOMAS G. THOMPSON and the THOMAS WASHINGTON in support of the Marathon 2 Project from 05 May 1985 to 07 September 1987 (NODC Accession 9400131)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature and salinity profiles were collected from CTD casts in the North Pacific Ocean from the THOMAS G. THOMPSON and the THOMAS WASHINGTON. Data were collected...

  6. Is Your Biobank Up to Standards? A Review of the National Canadian Tissue Repository Network Required Operational Practice Standards and the Controlled Documents of a Certified Biobank.

    Science.gov (United States)

    Hartman, Victoria; Castillo-Pelayo, Tania; Babinszky, Sindy; Dee, Simon; Leblanc, Jodi; Matzke, Lise; O'Donoghue, Sheila; Carpenter, Jane; Carter, Candace; Rush, Amanda; Byrne, Jennifer; Barnes, Rebecca; Mes-Messons, Anne-Marie; Watson, Peter

    2017-11-17

    Ongoing quality management is an essential part of biobank operations and the creation of high quality biospecimen resources. Adhering to the standards of a national biobanking network is a way to reduce variability between individual biobank processes, resulting in cross biobank compatibility and more consistent support for health researchers. The Canadian Tissue Repository Network (CTRNet) implemented a set of required operational practices (ROPs) in 2011 and these serve as the standards and basis for the CTRNet biobank certification program. A review of these 13 ROPs covering 314 directives was conducted after 5 years to identify areas for revision and update, leading to changes to 7/314 directives (2.3%). A review of all internal controlled documents (including policies, standard operating procedures and guides, and forms for actions and processes) used by the BC Cancer Agency's Tumor Tissue Repository (BCCA-TTR) to conform to these ROPs was then conducted. Changes were made to 20/106 (19%) of BCCA-TTR documents. We conclude that a substantial fraction of internal controlled documents require updates at regular intervals to accommodate changes in best practices. Reviewing documentation is an essential aspect of keeping up to date with best practices and ensuring the quality of biospecimens and data managed by biobanks.

  7. Hybrid alginate-polyester bimodal network hydrogel for tissue engineering--Influence of structured water on long-term cellular growth.

    Science.gov (United States)

    Finosh, G T; Jayabalan, M; Vandana, S; Raghu, K G

    2015-11-01

    The development of biodegradable scaffolds (which promote cell-binding, proliferation, long-term cell viability and required biomechanical stability) for cardiac tissue engineering is a challenge. In this study, biosynthetic amphiphilic hybrid hydrogels were prepared using a graft comacromer of natural polysaccharide alginate and synthetic polyester polypropylene fumarate (PPF). Monomodal network hydrogel (HPAS-NO) and bimodal network hydrogel (HPAS-AA) were prepared. Between the two hydrogels, HPAS-AA hydrogel excels over the HPAS-NO hydrogel. HPAS-AA hydrogel is mechanically more stable in the culture medium and undergoes gradual degradation in vitro in PBS (phosphate buffered saline). HPAS-AA contains nano-porous structure and acquires structured water (non-freezing-bound water) (53.457%) along with free water (11.773%). It absorbs more plasma proteins and prevents platelet adsorption and hemolysis when contacted with blood. HPAS-AA hydrogel is cytocompatible and promote 3D cell growth (≈ 70%) of L929 fibroblast even after 18 days and H9C2 cardiomyoblasts. The enhanced and long-term cellular growth of HPAS-AA hydrogel is attributed to the cell responsive features of structured water. HPAS-AA hydrogel can be a better candidate for cardiac tissue engineering applications. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. Nests of the Brazilian squirrel Sciurus ingrami Thomas (Rodentia, Sciuridae Ninhos do esquilo brasileiro Sciurus ingrami Thomas (Rodentia, Sciuridae

    Directory of Open Access Journals (Sweden)

    Cibele A. Alvarenga

    2005-09-01

    Full Text Available Descriptions of Sciurus ingrami Thomas, 1901 nests are not available in the literature. In this study, a survey was made of the distribution of S. ingrami nests in a woodlot located near to the headquarters of the Serra do Caraça Reserve, in state of Minas Gerais, where there is a high concentration of Syagrus romanzoffiana (Chamisso Glassman palm tree, among other exotic tree species. The nest-building behaviour and the nest characteristics, such as height from the ground, total circumference, diameter of the entrance, and the position of the nest in the tree - in the crown, along the trunk or in a side branch, were described.Não existe na literatura a descrição de ninhos de Sciurus ingrami Thomas, 1901. Neste estudo, foi examinada a distribuição espacial de ninhos desta espécie, localizados em área de vegetação de crescimento secundário, próxima a área construída da Reserva Particular do Patrimônio Natural Serra do Caraça, Minas Gerais, onde há grande concentração da palmeira Syagrus romanzoffiana (Chamisso Glassman, entre outras espécies exóticas de árvores. O comportamento de construção e as características dos ninhos, tais como, altura em relação ao solo, circunferência total, diâmetro da entrada e a posição dos ninhos na árvore foram descritos.

  9. The light bulb, cystoscopy, and Thomas Alva Edison.

    Science.gov (United States)

    Moran, Michael E

    2010-09-01

    Thomas Alva Edison was an icon of American achievement who literally invented the 20th century. Although best known as the inventor of the electric light bulb, the phonograph, and motion pictures, he also left a lasting legacy via peripheral developmental applications, such as endoscopes. A review of published urologic writings about incandescent cystoscopes was cross-referenced to writings about or from Edison. Important events that allowed transference of technology from the Edison laboratory to clinical practice were emphasized. Edison was born in 1847 while Lincoln was serving in Congress; he died in 1931 when Hoover struggled with the Great Depression. Edison's life spanned the formative period of America that Henry Adams called the "coming of age." Edison received a Sprengel vacuum device in late 1879, and as usual, he was able to tweak the machine to better performance. For 5 days in October, 16 to 21, he improved the vacuum from 1/100,000 to 1/1,000,000 atm, and his first incandescent bulb burned softly. On December 21, 1879, he leaked the story to N.Y. Herald journalist Marshall Fox, and the world was notified of the light bulb. Special Christmas light visits started in Menlo Park just 4 days later. Edison patented the screw cap for easy changes, and the first bulbs sold for 40 cents (cost $1.40). 100,000 bulbs sold in 1882, 4 million by 1892, and 45 million in 1903. Immediately, competitors and specialty manufacturers entered the market. Dr. Henry Koch and Charles Preston in Rochester, N.Y., developed a smaller, low amperage bulb that could be fitted to medical devices. No discussion of electricity and modern applications would be complete without some discussion of Thomas Alva Edison and his sentinel contributions. The first church, post office, and ship were illuminated in 1892. The first hotel, theater, and electric sign were in 1893. The rapidity of dispersal and secondary applications of Edison's inventions is typified by the rise of cystoscopes

  10. American Connections: The Early Works of Thomas Bang

    Directory of Open Access Journals (Sweden)

    Ring Petersen, Anne

    2015-09-01

    Full Text Available The Danish artist Thomas Bang spent his early years in the USA. The works he created in this formative period were thus profoundly shaped by the contemporary movements in American art of the 1960s and 1970s when sculpture, or to be more precise, three-dimensional work became a hotbed of expansive experiments. This article traces how Bang made a radical move from painting to sculpture, which was characteristic of that time, and how he developed his artistic idiom by taking an active part in some of the seminal new departures in American art, in particular process art and post-minimalism. By leaping forward to Bang's later works produced after his return to Denmark, the article also demonstrates how the sculptural syntax and working principles developed in the early works still underlie and structure the artist's more allegorical sculptures and installations from the 2000s, thus testifying to the lasting impact of Bang's American period, which remains the key to understanding his works.

  11. Thomas Willis, the Restoration and the First Works of Neurology.

    Science.gov (United States)

    Caron, Louis

    2015-10-01

    This article provides a new consideration of how Thomas Willis (1621-75) came to write the first works of 'neurology', which was in its time a novel use of cerebral and neural anatomy to defend philosophical claims about the mind. Willis's neurology was shaped by the immediate political and religious contexts of the English Civil War and Restoration. Accordingly, the majority of this paper is devoted to uncovering the political necessities Willis faced during the Restoration of the English monarchy in 1660, with particular focus on the significance of Willis's dedication of his neurology and natural philosophy to the Archbishop of Canterbury, Gilbert Sheldon. Because the Restoration of Charles II brought only a semblance of order and peace, Willis and his allies understood the need for a coherent defense of the authority of the English church and its liturgy. Of particular importance to Sheldon and Willis (and to others in Sheldon's circle) were the specific ceremonies described in the Book of Common Prayer, a manual that directed the congregation to assume various postures during public worship. This article demonstrates that Willis's neurology should be read as an intervention in these debates, that his neurology would have been read at the time as an attempt to ground orthodox worship in the structure of the brain and nerves. The political necessities that helped to shape Willis's project also help us to better understand Willis's innovative insistence that philosophical statements about the mind should be formulated only after a comprehensive anatomical investigation of the brain and nerves.

  12. Nietzche's echo--a dialogue with Thomas Altizer.

    Science.gov (United States)

    Moss, David M

    2010-03-01

    Prophets provoke psychological unrest, especially when exposing accepted beliefs as profound deceptions. The biblical prophets exemplify such confrontation as do certain atheists ardently opposed to the images of God created by those seers. The German philosopher Friedrich Nietzsche dramatically illustrates this type of counterforce to the Judeo-Christian tradition. His prophet Zarathustra is intended to be a model for the modern mind, one free of superstitions inflicted by antiquated religious dogma. Nietzsche's credo "God is dead" served as a declaration for the nineteenth century. In the twentieth century, it became a theological diagnosis. As a "movement," or "tenor," the death of God or radical theology was spearheaded by Thomas Altizer, a well-published young professor center-staged during the turbulent 1960s. His work foreshadows a new strain of atheism currently represented by biologist Richard Dawkins (2006, The God delusion. New York: Houghton Mifflin), philosopher Daniel Dennett (2006, Breaking the spell. New York: Penquin), neuroscientist Sam Harris (2004, The end of faith. New York: W.W. Norton; 2008, Letter to a Christian nation. New York: Vintage), journalist Christopher Hitchens (2007, God is not great. New York: Twelve), and mathematician John Allen Paulos (Paulos 2008, Irreligion. New York: Hill & Wang). This twenty-first century crusade against belief in God is best understood as a psychodynamic ignited by Altizer's Christian atheism. The present dialogue reflects that dynamic while the prologue and epilogue reveal evidence of Providence amidst claims of God's demise in contemporary history.

  13. Thomas Alva Edison (170th Anniversary of His Birth

    Directory of Open Access Journals (Sweden)

    V. P. Samokhin

    2017-01-01

    Full Text Available A brief overview of the major technical achievements of Thomas Edison, an outstanding American inventor, author of more than 1,000 US patents and several thousand patents in other countries, honorary academician of the USSR. Presents biographical information and details of the formation of Edison, his work as a telegrapher, organizing the world's first industrial research laboratory for the continuous development of technological innovations, as well as some interesting facts about his life and work. This includes pioneering work on the creation of Edison incandescent lighting, the distribution system for their power and cinema. Edison can be considered the founder of the multimedia technology, as it was the beginning of the invention of the phonograph of phonics and disc phonograph recording of depth was the basis of mechanical recording. Name Edison are geographic features, a lot of companies and educational institutions. He was a member of many Academies of Sciences and entered the list of "100 most outstanding people for 1,000 years." Bust open in the Hall of Fame of great Americans, and a bronze statue - sculptures at the National Hall on Capitol Hill.

  14. THEOLOGY AS CREATIVE LANGUAGE. THE CASE OF THOMAS BROOKS

    Directory of Open Access Journals (Sweden)

    Ciprian SIMUȚ

    2015-12-01

    Full Text Available The problem of theological language has been a hindrance in coming closer to God, ever since complex patterns of thought have combined with the theological inquiry. The conclusion that helped Protestantism gain ground was bringing the theological message of the Bible to the understanding of every-day believer. An effort was made to explain how God works in history, and how to become more like Christ in one’s every-day life. However, mere copying was not the foundation of Christianity. Inner conviction born out of understanding the explanation from the Biblical message was crucial. Thomas Brooks was one of the protestant theologians who aimed to explain how the Devil and evil work against the believer, in order to create chaos, disorder, sorrow, hatred, deception, and ignorance. He did this by transforming the theological message into creative language, using every-day images in order to create a relation between theology and praxis. This paper will analyze some of the aspects found in Brooks’ theological presentation, in order to show how theology could be used for the benefit of the individual believer, as well as for the benefit of society.

  15. The many encounters of Thomas Kuhn and French epistemology.

    Science.gov (United States)

    Simons, Massimiliano

    2017-02-01

    The work of Thomas Kuhn has been very influential in Anglo-American philosophy of science and it is claimed that it has initiated the historical turn. Although this might be the case for English speaking countries, in France an historical approach has always been the rule. This article aims to investigate the similarities and differences between Kuhn and French philosophy of science or 'French epistemology'. The first part will argue that he is influenced by French epistemologists, but by lesser known authors than often thought. The second part focuses on the reactions of French epistemologists on Kuhn's work, which were often very critical. It is argued that behind some superficial similarities there are deep disagreements between Kuhn and French epistemology. This is finally shown by a brief comparison with the reaction of more recent French philosophers of science, who distance themselves from French epistemology and are more positive about Kuhn. Based on these diverse appreciations of Kuhn, a typology of the different positions within the philosophy of science is suggested. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Thomas Vincent McEvilly (1934-2002)

    Science.gov (United States)

    Bolt, Bruce A.

    On 22 February 2002, the seismological community lost one of its most engaging and distinguished members, Thomas McEvilly (or Tom as he was known to all), professor emeritus of geophysics at the University of California, Berkeley He was undergoing treatment at St. Anthony's Medical Center in St. Louis, the city of his birth. McEvilly was an AGU Fellow, and a member of the Seismology Section (1957).His contributions to geophysics ranged widely particularly in seismology. His many publications investigated, among other topics, seismic crustal profiling, earthquake source properties, test-ban treaty verification methods, earthquake prediction, and seismographic instrumentation. He was also a Fellow of the American Association for the Advancement of Science, and an honorary member of the Seismological Society of America. McEvilly served on many scientific advisory committees for government, university and professional organizations, including UNESCO, the National Science Foundation, the U.S. Geological Survey and the Department of Energy he also held the notable position of chairman of the Committee of Seismology of the National Academy of Science/National Research Council from 1981 to 1983.

  17. Thomas Hardy, Provincial Geology and the Material Imagination

    Directory of Open Access Journals (Sweden)

    Adelene Buckland

    2008-04-01

    Full Text Available This essay explores the nineteenth-century traffic and exchange of fossils and natural-historical objects between province and metropolis as represented by two very different geological writers of the period, the fossil collector Gideon Mantell and the novelist Thomas Hardy. The men are connected through Mantell's 'The Wonders of Geology', the sixth edition of which (1848 Hardy read and utilised for his descriptions of the geological past in his third novel, 'A Pair of Blue Eyes' (1873. These two texts demonstrate a powerful investment in determining the meaning of the geological object according to the social and geographical spaces in which it is discovered, displayed, and discussed, so that the scientific object becomes the site around which complex cultural politics coalesce and sit in tension. In its consideration of the relationship between place and meaning in science, and in its focus on scientific material culture, this essay attempts to disrupt the current spotlight on the interrelationships between scientific law and narrative pattern in Victorian literary studies. Instead, it hopes to contribute to a discussion of the ways in which the novel's attention to scientific objects rather than narratives made it an important site of epistemological enquiry into the basis of scientific knowledge and the inseparability of that knowledge from the discourses and spaces which produced it.

  18. Tragic Richness in the Major Novels of Thomas Hardy

    Directory of Open Access Journals (Sweden)

    V. Sudhakar Naidu

    2013-12-01

    Full Text Available Thomas Hardy is a poet, short story writer and novelist of eminence. He has freely adopted ideas from classical drama, Christian tragic element and Shakespearean tragedy and framed his own tragic pattern. He has explored the depth of silent sorrow and suffering in all his great tragedies. His heroes and heroines are all star-crossed souls, struggling against the powerful cosmic forces. Henchard, Giles Winterborne, Clym, Eustacia Vye, Tess, Jude, Sue and the other characters of Hardy meet with an end that is tragic or miserable. For them, happiness is an interlude in the general drama of pain. It is seen that the wrong choices and temperamental differences led to tragic gloom in love and marriage. The elements of chance, fate or coincidence also play a vital role in creating tragedy. To him, life is a struggle between man and impersonal forces and life is a fruitless effort of man. This tragic content in his major novels, which is considered as an important aspect of his novels by many critics, has been investigated and explored from a critical perspective in the present article.

  19. Tacit knowledge in philosophy of science of Thomas Kuhn

    Directory of Open Access Journals (Sweden)

    Cristian Norambuena Ureta

    2011-10-01

    Full Text Available The article focuses on a fundamental piece of the theoretical framework where the work ofThomas Kuhn develops, tacit knowledge. The importance of such a kind of knowledge, that is notpossible (nor necessary to reduce into rules and definitions, and that is not acquired with exclusiverecourse to logic is essential for Kuhn within Science. The article investigates the origins of this idea inkuhnian work, searching for influences exerted by Gestalt psychology and the second Wittgenstein. Itexamines the relation between this idea and Kuhn’s most known and important philosophicalcontributions, the concept of paradigm (exemplar and the incommensurability of scientific theories;confirming that without the utilization of a kind of knowledge of this nature such ideas would not havehad the necessary support to be stated. At the end of the article, the importance of tacit knowledgethrough the use of metaphor and thought experiments is revised, as vehicles through which the scientistcan put himself in touch with this dimension of knowledge.

  20. Publish or Perish: The Case of Thomas Harriot

    Science.gov (United States)

    Gingerich, Owen

    2007-12-01

    In 1585 the 25-year old Thomas Harriot set foot on Roanoke Island, just inside the barrier island of what is now North Carolina but what was then called Virginia. Harriot, under the patronage of Sir Walter Raleigh, was the cartographer and navigational expert on a colonizing expedition, and he was perhaps the first scientist to take up temporary residence in North America. On his return to Britain he published, at the insistence of Raleigh, a now quite rare promotional pamphlet, A briefe and true report of the New Found Land of Virginia (1588). This was the only thing he published in his lifetime, so his reputation virtually perished. Centuries later his 10,000 pages of manuscripts began to be investigated, so we now know that he anticipated Galileo in the discovery of sunspots, though his telescopic drawings of the moon were strongly influenced by what he saw in Galileo's Sidereus nuncius. Harriot corresponded briefly with Kepler, and had he shared his optical observations, the law of refraction might have become available much earlier. Harriot died in 1621 of cancer of the nose, possibly exacerbated by a habit he helped to import from America, "drinking” tobacco fumes.

  1. A Comparison of MullÁ Sadra\\\\\\'s and Thomas Aquinas’ Spiritual Psychology Centering on the Structure of

    Directory of Open Access Journals (Sweden)

    Reza Rezazadeh

    2013-03-01

    Full Text Available Spiritual psychology has a special status and essential role in philosophical theology of Thomas Aquinas and Mulla Sadra. Characteristics of such status and role can be clearly found in compiling structure of “Summa Theologiae” of Aquinas and “Asfar” of Sadra. A Comparative survey of this fundamental element in two systematical structures indicates that these philosophers has so similarly regarded spiritual psychology in networks of metaphysical teachings and doctrines that considered both ontological aspect of human being as caused/creature and his epistemological statue or situation about God, himself and world. But the issue of the way of human beings toward God in two mentioned systems has provided two different types of justification and compiling structure, because of different Christian background of Aquinas’ thought and Islamic background of Sadra's thought.

  2. NANOG Plays a Hierarchical Role in the Transcription Network Regulating the Pluripotency and Plasticity of Adipose Tissue-Derived Stem Cells.

    Science.gov (United States)

    Pitrone, Maria; Pizzolanti, Giuseppe; Tomasello, Laura; Coppola, Antonina; Morini, Lorenzo; Pantuso, Gianni; Ficarella, Romina; Guarnotta, Valentina; Perrini, Sebastio; Giorgino, Francesco; Giordano, Carla

    2017-05-23

    The stromal vascular cell fraction (SVF) of visceral and subcutaneous adipose tissue (VAT and SAT) has increasingly come into focus in stem cell research, since these compartments represent a rich source of multipotent adipose-derived stem cells (ASCs). ASCs exhibit a self-renewal potential and differentiation capacity. Our aim was to study the different expression of the embryonic stem cell markers NANOG (homeobox protein NANOG), SOX2 (SRY (sex determining region Y)-box 2) and OCT4 (octamer-binding transcription factor 4) and to evaluate if there exists a hierarchal role in this network in ASCs derived from both SAT and VAT. ASCs were isolated from SAT and VAT biopsies of 72 consenting patients (23 men, 47 women; age 45 ± 10; BMI between 25 ± 5 and 30 ± 5 range) undergoing elective open-abdominal surgery. Sphere-forming capability was evaluated by plating cells in low adhesion plastic. Stem cell markers CD90, CD105, CD29, CD31, CD45 and CD146 were analyzed by flow cytometry, and the stem cell transcription factors NANOG, SOX2 and OCT4 were detected by immunoblotting and real-time PCR. NANOG, SOX2 and OCT4 interplay was explored by gene silencing. ASCs from VAT and SAT confirmed their mesenchymal stem cell (MSC) phenotype expressing the specific MSC markers CD90, CD105, NANOG, SOX2 and OCT4. NANOG silencing induced a significant OCT4 (70 ± 0.05%) and SOX2 (75 ± 0.03%) downregulation, whereas SOX2 silencing did not affect NANOG gene expression. Adipose tissue is an important source of MSC, and siRNA experiments endorse a hierarchical role of NANOG in the complex transcription network that regulates pluripotency.

  3. Thomas M. Prymak. Gathering a Heritage: Ukrainian, Slavonic, and Ethnic Canada and the USA

    Directory of Open Access Journals (Sweden)

    Danielle Morrissette

    2017-03-01

    Full Text Available Book review of Thomas M. Prymak. Gathering a Heritage: Ukrainian, Slavonic, and Ethnic Canada and the USA. U of Toronto P, 2015. xiv, 370 pp. Illustrations. Tables. Appendix. Notes. Index. $29.95, paper.

  4. NOAA TIFF Graphic- 0.5m Backscatter Mosaic of St. Thomas, US Virgin Islands, 2004

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a 0.5 meter resolution backscatter mosaic of the south shore of St. Thomas, US Virgin Islands.NOAA's NOS/NCCOS/CCMA Biogeography Team and...

  5. Backscatter 0.5m TIFF Mosaic of St. Thomas, US Virgin Islands, 2004

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a 0.5 meter resolution backscatter mosaic of the south shore of St. Thomas, US Virgin Islands. NOAA's NOS/NCCOS/CCMA Biogeography Team and...

  6. WATER TEMPERATURE and Other Data from THOMAS G. THOMPSON from 19920323 to 19921020 (NODC Accession 9700194)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Oxygen production, abundance of marine snow, and other data were collected from bottle and video camera casts in the Pacific Ocean from the THOMAS G. THOMPSON from...

  7. National Status and Trends: Bioeffects Program - St. Thomas East End Reserves (STEER) Database

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The purpose of this effort was to characterize the extent and magnitude of chemical contamination in the St. Thomas East End Reserves or STEER, as part of a larger...

  8. Tartu ehk unbewusste Ängste / Rauno Thomas Moss ; interv. Harry Liivrand

    Index Scriptorium Estoniae

    Moss, Rauno Thomas, 1977-

    2008-01-01

    Rauno Thomas Mossi (1977) näitus "Silent Tartu aka Clinical" Vaal galeriis. Kunstniku eluloolisi andmeid, loomingust, alasti mehekeha kujutamisest. Töötab Tartu Ülikoolis joonistamise ja plastilise anatoomia õppejõuna. Tema lemmikkunstnikud

  9. EAARL-B Submerged Topography—Saint Thomas, U.S. Virgin Islands, 2014

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — ASCII XYZ point cloud data for a portion of the submerged environs of Saint Thomas, U.S. Virgin Islands, was produced from remotely sensed, geographically referenced...

  10. EAARL-B Submerged Topography--Saint Thomas, U.S. Virgin Islands, 2014

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — A submerged topography Digital Elevation Model (DEM) mosaic for a portion of the submerged environs of Saint Thomas, U.S. Virgin Islands, was produced from remotely...

  11. Contributions to the knowledge of Banasa Stål (Hemiptera, Heteroptera, Pentatomidae: Banasa chaca Thomas

    Directory of Open Access Journals (Sweden)

    Thereza de Almeida Garbelotto

    2011-09-01

    Full Text Available Contributions to the knowledge of Banasa Stål (Hemiptera, Heteroptera, Pentatomidae: Banasa chaca Thomas. The male of Banasa chaca Thomas is described with emphasis on external and internal genitalia and the female internal genitalia is described. Banasa chaca is newly recorded from Buenos Aires Province (Argentina.Contribuições ao conhecimento de Banasa Stål (Hemiptera: Heteroptera: Pentatomidae: Pentatominae: Banasa chaca Thomas. O macho de Banasa chaca Thomas é descrito com ênfase na genitália externa e interna, também é descrita a genitália interna da fêmea. Banasa chaca é registrada pela primeira vez na província de Buenos Aires (Argentina.

  12. EAARL-B Submerged Topography - Saint Croix and Saint Thomas, U.S. Virgin Islands, 2014

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Binary point-cloud data for part of the submerged environs of Saint Croix and Saint Thomas, U.S. Virgin Islands, were produced from remotely sensed, geographically...

  13. Thomas Carlyle and the Characteristics of Nineteenth-Century English Literature

    DEFF Research Database (Denmark)

    Schatz-Jakobsen, Claus

    2001-01-01

    Artiklen diskuterer den skotske forfatter Thomas Carlyles plads i den engelske litteraturs historie og argumenterer for at hans skrift, "Characteristics" (1831), selv dramatiserer og dekonstruerer litteraturhistoriske grænsedragninger....

  14. Corpus Areopagiticum dans l’interprétation de saint Thomas d’Aquin

    Directory of Open Access Journals (Sweden)

    Florin Crîşmăreanu

    2011-06-01

    Full Text Available In this article I intend to highlight a fundamental difference that I have seized between Dionysius interpreted by Thomas of Aquinas and the author of Corpus Areopagiticum. In the first stage, I will present the way in which Thomas understands Dionysius as a simple Aristotelian, then the confession of faith of saint Thomas regarding that particular Dionysius from The Acts of Apostles 17, 34, without, however, noticing the fact that Dionysius invokes the Holy Trinity in his texts, a dogma established only in the first Ecumenical Council of Nicaea (325. However, the most obvious issue that radically separates the two thinkers (Dionysius and Thomas is their way of understanding theology (θεολογία.

  15. Bathymetry 1m GRID of St. Thomas, US Virgin Islands, 2004, UTM 20 WGS84

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains an ESRI Grid with 1 meter cell size representing the bathymetry of the south shore of St. Thomas, US Virgin Islands. NOAA's NOS/NCCOS/CCMA...

  16. Astronaut Andy Thomas holds facsimile Olympic torch like one to fly on STS-101

    Science.gov (United States)

    2000-01-01

    Astronaut Andy Thomas holds a facsimile of the Olympic torch that is being carried on Space Shuttle Atlantis during mission STS- 101. Thomas is from Australia, which is the site of the 2000 Olympics. He coordinated the effort to have the torch added to the manifest so that it would truly circle the Earth in the spirit of the worldwide sporting event. The Sydney Olympic Torch Relay will arrive in Australia on June 8. The games begin Sept. 1.

  17. Questions and Answers for Ken Thomas' "Intra-Extra Vehicular Activity Russian and Gemini Spacesuits" Presentation

    Science.gov (United States)

    Thomas, Kenneth S.

    2016-01-01

    Kenneth Thomas will discuss the Intra-Extra Vehicular Activity Russian & Gemini spacesuits. While the United States and Russia adapted to existing launch- and reentry-type suits to allow the first human ventures into the vacuum of space, there were differences in execution and capabilities. Mr. Thomas will discuss the advantages and disadvantages of this approach compared to exclusively intravehicular or extra-vehicular suit systems.

  18. Characterization of Sequential Collagen-Poly(ethylene glycol) Diacrylat Interpenetrating Networks and Initial Assessment of their Potential for Vascular Tissue Engineering

    Science.gov (United States)

    Munoz-Pinto, Dany J.; Jimenez-Vergara, Andrea Carolina; Gharat, Tanmay; Hahn, Mariah S.

    2014-01-01

    Collagen hydrogels have been widely investigated as scaffolds for vascular tissue engineering due in part to the capacity of collagen to promote robust cell adhesion and elongation. However, collagen hydrogels display relatively low stiffness and strength, are thrombogenic, and are highly susceptible to cell-mediated contraction. In the current work, we develop and characterize a sequentially-formed interpenetrating network (IPN) that retains the benefits of collagen, but which displays enhanced mechanical stiffness and strength, improved thromboresistance, high physical stability and resistance to contraction. In this strategy, we first form a collagen hydrogel, infuse this hydrogel with poly(ethylene glycol) diacrylate (PEGDA), and subsequently crosslink the PEGDA by exposure to longwave UV light. These collagen-PEGDA IPNs allow for cell encapsulation during the fabrication process with greater than 90% cell viability via inclusion of cells within the collagen hydrogel precursor solution. Furthermore, the degree of cell spreading within the IPNs can be tuned from rounded to fully elongated by varying the time delay between the formation of the cell-laden collagen hydrogel and the formation of the PEGDA network. We also demonstrate that these collagen-PEGDA IPNs are able to support the initial stages of smooth muscle cell lineage progression by elongated human mesenchymal stems cells. PMID:25433604

  19. Scheduling and Topology Design in Networks with Directional Antennas

    Science.gov (United States)

    2017-05-19

    Wireless Mesh Networks , IEEE ICC 2006. [7] E. Gelal, et. al., “Topology Management in Directional Antenna-Equipped Ad Hoc Networks , IEEE Trans. Mobile...Scheduling and Topology Design in Networks with Directional Antennas Thomas Stahlbuhk, Nathaniel M. Jones, Brooke Shrader Lincoln Laboratory...Massachusetts Institute of Technology Lexington, Massachusetts 02420–9108 Abstract—In multihop wireless networks equipped with direc- tional antennas, network

  20. Automated cancer stem cell recognition in H and E stained tissue using convolutional neural networks and color deconvolution

    Science.gov (United States)

    Aichinger, Wolfgang; Krappe, Sebastian; Cetin, A. Enis; Cetin-Atalay, Rengul; Üner, Aysegül; Benz, Michaela; Wittenberg, Thomas; Stamminger, Marc; Münzenmayer, Christian

    2017-03-01

    The analysis and interpretation of histopathological samples and images is an important discipline in the diagnosis of various diseases, especially cancer. An important factor in prognosis and treatment with the aim of a precision medicine is the determination of so-called cancer stem cells (CSC) which are known for their resistance to chemotherapeutic treatment and involvement in tumor recurrence. Using immunohistochemistry with CSC markers like CD13, CD133 and others is one way to identify CSC. In our work we aim at identifying CSC presence on ubiquitous Hematoxilyn and Eosin (HE) staining as an inexpensive tool for routine histopathology based on their distinct morphological features. We present initial results of a new method based on color deconvolution (CD) and convolutional neural networks (CNN). This method performs favorably (accuracy 0.936) in comparison with a state-of-the-art method based on 1DSIFT and eigen-analysis feature sets evaluated on the same image database. We also show that accuracy of the CNN is improved by the CD pre-processing.

  1. The Reverend Thomas Bayes, FRS: A Biography to Celebrate the Tercentenary of His Birth

    Science.gov (United States)

    Bellhouse, D. R.

    2004-07-01

    Thomas Bayes, from whom Bayes theorem takes its name, was probably born in 1701, so the year 2001 marked the 300th anniversary of his birth. This biography was written to celebrate this anniversary. The current sketch of his life includes his family background and education, as well as his scientific and theological work. In contrast to some, but not all, biographies of Bayes, the current biography is an attempt to cover areas beyond Bayes' scientific work. When commenting on the writing of scientific biography, Pearson [(1978). The History of Statistics in the 17th and 18th Centuries.... Charles Griffin and Company, London] stated, "it is impossible to understand a man's work unless you understand something of his character and unless you understand something of his environment. And his environment means the state of affairs social and political of his own age." The intention here is to follow this general approach to biography. There is very little primary source material on Bayes and his work. For example, only three of his letters and a notebook containing some sketches of his own work, almost all unpublished, as well as notes on the work of others are known to have survived. Neither the letters nor the notebook is dated, and only one of the letters can be dated accurately from internal evidence. This biography contains new information about Bayes. In particular, among the papers of the 2nd Earl Stanhope, letters and papers of Bayes have been uncovered that previously were not known to exist. The letters indirectly confirm the centrality of Stanhope in Bayes' election to the Royal Society. They also provide evidence that Bayes was part of a network of mathematicians initially centered on Stanhope. In addition, the letters shed light on Bayes' work in infinite series.

  2. Poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate)-poly(vinyl alcohol)/poly(acrylic acid) interpenetrating polymer networks for improving optrode-neural tissue interface in optogenetics.

    Science.gov (United States)

    Lu, Yi; Li, Yanling; Pan, Jianqing; Wei, Pengfei; Liu, Nan; Wu, Bifeng; Cheng, Jinbo; Lu, Caiyi; Wang, Liping

    2012-01-01

    The field of optogenetics has been successfully used to understand the mechanisms of neuropsychiatric diseases through the precise spatial and temporal control of specific groups of neurons in a neural circuitry. However, it remains a great challenge to integrate optogenetic modulation with electrophysiological and behavioral read out methods as a means to explore the causal, temporally precise, and behaviorally relevant interactions of neurons in the specific circuits of freely behaving animals. In this study, an eight-channel chronically implantable optrode array was fabricated and modified with poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate)-poly(vinyl alcohol)/poly(acrylic acid) interpenetrating polymer networks (PEDOT/PSS-PVA/PAA IPNs) for improving the optrode-neural tissue interface. The conducting polymer-hydrogel IPN films exhibited a significantly higher capacitance and lower electrochemical impedance at 1 kHz as compared to unmodified optrode sites and showed significantly improved mechanical and electrochemical stability as compared to pure conducting polymer films. The cell attachment and neurite outgrowth of rat pheochromocytoma (PC12) cells on the IPN films were clearly observed through calcein-AM staining. Furthermore, the optrode arrays were chronically implanted into the hippocampus of SD rats after the lentiviral expression of synapsin-ChR2-EYFP, and light-evoked, frequency-dependant action potentials were obtained in freely moving animals. The electrical recording results suggested that the modified optrode arrays showed significantly reduced impedance and RMS noise and an improved SNR as compared to unmodified sites, which may have benefited from the improved electrochemical performance and biocompatibility of the deposited IPN films. All these characteristics are greatly desired in optogenetic applications, and the fabrication method of conducting polymer-hydrogel IPNs can be easily integrated with other modification methods to build a

  3. Llewellyn Hilleth Thomas: An appraisal of an under-appreciated polymath

    Science.gov (United States)

    Jackson, John David

    2010-02-01

    Llewellyn Hilleth Thomas was born in 1903 and died in 1992 at the age of 88. His name is known by most for only two things, Thomas precession and the Thomas-Fermi atom. The many other facets of his career - astrophysics, atomic and molecular physics, nonlinear problems, accelerator physics, magnetohydrodynamics, computer design principles and software and hardware - are largely unknown or forgotten. I review his whole career - his early schooling, his time at Cambridge, then Copenhagen in 1925-26, and back to Cambridge, his move to the US as an assistant professor at Ohio State University in 1929, his wartime years at the Ballistic Research Laboratory, Aberdeen Proving Grounds, then in 1946 his new career as a unique resource at IBM's Watson Scientific Computing Laboratory and Columbia University until his first retirement in 1968, and his twilight years at North Carolina State University. Although the Thomas precession and the Thomas-Fermi atom may be the jewels in his crown, his many other accomplishments add to our appreciation of this consummate applied mathematician and physicist. )

  4. Obituary: Thomas C. Van Flandern (1940-2009)

    Science.gov (United States)

    Dunham, David; Slabinski, Victor

    2011-12-01

    Dr. Thomas Charles Van Flandern, an expert in celestial mechanics and cosmology, died January 9, 2009 in Seattle, Washington, of colon cancer. He was 68. Van Flandern was an astronomer at the U.S. Naval Observatory from 1963 to 1983. He developed software to predict and analyze lunar occultations to improve lunar orbital and fundamental star catalog data. In later years he championed increasingly controversial theories. But his 1978 prediction that some asteroids have natural satellites, which was almost universally rejected, was verified when the Galileo spacecraft photographed Dactyl, a satellite of (243) Ida, during its flyby in 1993. Besides astronomy and computers, he had strong interests in biochemistry and nutrition, and he ran a business selling personal computers in the 1980s. Tom Van Flandern was born June 26, 1940 in Cleveland, Ohio, the first child of Robert F. Van Flandern and Anna Mary Haley. His father, a police officer, left the family when Tom Van Flandern was 5. His mother died when he was 16; he and his siblings then lived with their grandmother, Margery Jobe, until he went to college. Tom Van Flandern became interested in astronomy as a child. He used his first telescope, purchased with newspaper delivery earnings, to observe lunar occultations, and then learned how to predict them, sparking a life-long passion for dynamical astronomy. While attending St. Ignatius High School, Van Flandern and fellow student Thomas Petrie organized the Cleveland Moonwatch team to observe the first artificial satellites, the only team without an adult organizer. In 1958, Tom Van Flandern entered Xavier University where he led the Cincinnati Moonwatch team. He learned computer programming at a summer job with General Electric and wrote software to calculate "look angles" from orbital elements. The Cincinnati team became a top producer of observations using these predictions. Tom obtained a B.S. in mathematics from Xavier in 1962. He spent the next year at

  5. Incomensurabilidade sem paradigmas: a revolução epistemológica de Thomas Kuhn

    OpenAIRE

    Wolff Neto, Carlos Gustavo

    2007-01-01

    O cenário geral da filosofia da ciência no século XX foi principalmente desenhado pelos traços epistemológicos do Positivismo Lógico e seu verificacionismo, pelo falsificacionismo popperiano, pelos programas de pesquisa lakatianos, pelo anarquismo epistemológico de Paul Feyerabend e pela filosofia da ciência de Thomas Kuhn. A partir desse cenário geral, esta dissertação analisa os aspectos principais da filosofia da ciência de Thomas Kuhn, o espectro das críticas que recebeu, as respostas que...

  6. Thomas George Lee - Implantation and early development of North American rodents

    DEFF Research Database (Denmark)

    Carter, Anthony Michael

    2011-01-01

    A century ago Thomas G. Lee amassed an unparalleled collection of developmental series of North American rodents such as the thirteen-lined ground squirrel, the Plains pocket gopher and Merriam's kangaroo rat. He was the first to describe the initial attachment of the squirrel blastocyst to the a......A century ago Thomas G. Lee amassed an unparalleled collection of developmental series of North American rodents such as the thirteen-lined ground squirrel, the Plains pocket gopher and Merriam's kangaroo rat. He was the first to describe the initial attachment of the squirrel blastocyst...

  7. Maximizing Interconnectedness and Availability in Directional Airborne RangeExtension Networks

    Science.gov (United States)

    2017-10-25

    surveyed advances in directional networking , noting much work in topology management , medium access control algorithms, aircraft-based directional... networks . Other issues, such as topology management and spectrum management , also require further research and development to enable high-quality...Maximizing Interconnectedness and Availability in Directional Airborne Range Extension Networks Thomas Shake, Rahul Amin MIT Lincoln Laboratory

  8. Peakonsul Jaanus Kirikmäe andis teenetemärgi praost Thomas Vagale / Airi Vaga ; foto: Harold Karu

    Index Scriptorium Estoniae

    Vaga, Airi, 1940-

    2008-01-01

    President Toomas Hendrik Ilves annetas iseseisvuspäeva puhul USA I praostkonna praostile Thomas Vagale Valgetähe IV klassi teenetemärgi. Teenetemärgi andis Thomas Vagale üle Eesti Vabariigi peakonsul Jaanus Kirikmäe

  9. Women's Perceptions and Labeling of Sexual Harassment in Academia before and after the Hill-Thomas Hearings.

    Science.gov (United States)

    Jaschik-Herman, Mollie L.; Fisk, Alene

    1995-01-01

    Investigated the effects of the Hill-Thomas hearings on changing sexual-harassment perceptions of female college students. Sixty-two students evaluated a video depicting a sexual harassment incident and provided their perceptions. Compared to a study conducted before the Hill-Thomas hearings, results indicate that publicity about the hearings…

  10. Planck constant/sup 4/-order variational Thomas-Fermi calculations of finite nuclei: The local case

    Energy Technology Data Exchange (ETDEWEB)

    Pi, M.; Vinas, X.; Garcias, F.; Barranco, M.

    1988-12-08

    We have solved the Planck constant/sup 4/-order Thomas-Fermi equations for a system of A nucleons in an external local potential. We present the results corresponding to Woods-Saxon and harmonic oscillator potentials for which the Thomas-Fermi results can be compared with Wigner-Kirkwood and Strutinsky averaged calculations.

  11. A two-step convolutional neural network based computer-aided detection scheme for automatically segmenting adipose tissue volume depicting on CT images.

    Science.gov (United States)

    Wang, Yunzhi; Qiu, Yuchen; Thai, Theresa; Moore, Kathleen; Liu, Hong; Zheng, Bin

    2017-06-01

    Accurately assessment of adipose tissue volume inside a human body plays an important role in predicting disease or cancer risk, diagnosis and prognosis. In order to overcome limitation of using only one subjectively selected CT image slice to estimate size of fat areas, this study aims to develop and test a computer-aided detection (CAD) scheme based on deep learning technique to automatically segment subcutaneous fat areas (SFA) and visceral fat areas (VFA) depicting on volumetric CT images. A retrospectively collected CT image dataset was divided into two independent training and testing groups. The proposed CAD framework consisted of two steps with two convolution neural networks (CNNs) namely, Selection-CNN and Segmentation-CNN. The first CNN was trained using 2,240 CT slices to select abdominal CT slices depicting SFA and VFA. The second CNN was trained with 84,000pixel patches and applied to the selected CT slices to identify fat-related pixels and assign them into SFA and VFA classes. Comparing to the manual CT slice selection and fat pixel segmentation results, the accuracy of CT slice selection using the Selection-CNN yielded 95.8%, while the accuracy of fat pixel segmentation using the Segmentation-CNN was 96.8%. This study demonstrated the feasibility of applying a new deep learning based CAD scheme to automatically recognize abdominal section of human body from CT scans and segment SFA and VFA from volumetric CT data with high accuracy or agreement with the manual segmentation results. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. A Possible Source For Sir Thomas More’s ‘Mountainish Inhumanity’

    NARCIS (Netherlands)

    Steenbergh, Kristine

    2017-01-01

    Shakespeare’s authorship of a scene in Sir Thomas More has been established as highly probable on the basis of an analysis of the handwriting, vocabulary, and collocations stylistics. His addition to the play was long believed to have been written soon after publication of the original play, in

  13. A Nobel Prize for empirical macroeconometrics: assessing the contributions of Thomas Sargent and Christopher Sims

    NARCIS (Netherlands)

    Boumans, M.; Sent, E.M.

    2013-01-01

    This paper provides an assessment of the contributions of the 2011 Nobel Prize winners, Thomas Sargent and Christopher Sims. They received the prize ‘for their empirical research on cause and effect in the macroeconomy’. The paper illustrates that Sargent entertained different interpretations of

  14. Music in a Flat World: Thomas L. Friedman's Ideas and Your Program

    Science.gov (United States)

    Beckmann-Collier, Aimee

    2009-01-01

    In his bestseller "The World is Flat," Pulitzer-winning author Thomas L. Friedman discusses the concept of globalization and its "flattening" effect on the world. Globalization is a hugely controversial and complex issue, and the effects of globalization and the new needs of a global society may be especially important to music educators. By…

  15. Jesus en geweld: Markus 12:1-12 (en par) en Thomas 65 | van Eck ...

    African Journals Online (AJOL)

    Jesus and violence: Mark 12:1-12 (and par) and. Thomas 65. As an advanced agrarian (aristocratic) society, first-century Palestine's social fabric was built on systemic tensions and conflicts between the elite (rulers) and the peasantry (the ruled). At the root of these conflicts were incompatible values (ideologies) and

  16. History of Science and Technology through Primary Sources: Thomas Jefferson's "Notes on the State of Virginia."

    Science.gov (United States)

    Mutchler, Kent D.

    1989-01-01

    Advocates the use of primary source materials in the classroom. Describes a lesson based on Thomas Jefferson's "Notes on the State of Virginia" in which students consider Jefferson's ideas on science and technology in the United States and Europe. Explores the links among science, technology, politics and social issues. (RW)

  17. The Reverend Thomas Jefferson Bowen: An Introductory Background to His Linguistic Works, 1850-1856

    Science.gov (United States)

    Awoniyi, Timothy A.

    1974-01-01

    A historical narrative background for the linguistic works of Thomas Jefferson Bowen, an American missionary who was the first non-Nigerian to publish a grammar of Yoruba (1858). The author points up a need for further scholarly review of Bowen's pioneering work and contribution to Yoruba studies. (JT)

  18. Thomas Merton’s poetics of translation in his letters to writers

    Directory of Open Access Journals (Sweden)

    Marcela María Raggio

    2016-08-01

    Full Text Available This article explores Thomas Merton’s poetics of translation as reflected in his letters to writers. There, Merton expresses his ideas on poetic translation, the methods and the experience of approaching foreign literature through translation. Then, a translation analysis of a sample revises the connection between Merton’s poetics and practice of translation.

  19. Electrical Connections: Letters to Thomas Edison in Response to His Claim of Solving Incandescent Lighting, 1878.

    Science.gov (United States)

    Bazerman, Charles

    1994-01-01

    Discusses the way in which letters sent to Thomas Edison following the report that he had solved the problem of incandescent lighting reveal the many discursive worlds that Edison's work touched. Claims these letters indicate how a technological accomplishment is also a multiple, complex social, and communicative accomplishment, creating place and…

  20. Thomas Edison's Inventions in the 1900s and Today: From "New" to You! [Lesson Plan].

    Science.gov (United States)

    2002

    The purpose of this lesson is to familiarize students with life and technology around 1900 so that they can better understand how Thomas Edison and his many inventions influenced both. Without some understanding of Edison's time, it is unclear just how significant an impact Edison had on the world, both then and now. While the incandescent light…

  1. the use of scripture in the imitation of christ by thomas a kempis 1.

    African Journals Online (AJOL)

    Thomas's critique was that, while the gospel, in material terms, was much read, little or no contact was made on the level of the spirit. The inner orientation of the gospel is geared to awakening the longings of the spirit. This demands of us as readers, that we yield to this natu- ral dynamic of the gospel. The full meaning of the ...

  2. Thomas Pringle's “The Emigrant's Cabin” and the Invention of Settler ...

    African Journals Online (AJOL)

    Although Thomas Pringle produced a significant body of work during his residence in the Cape Colony, he also wrote extensively about this experience from a metropolitan vantage heavily invested in his public role as the secretary of the Anti-Slavery Society and an active campaigner in parliamentary pressure groups ...

  3. Competing Conceptions of Citizenship Education: Thomas Jesse Jones and Carter G. Woodson

    Science.gov (United States)

    Dilworth, Paullette Patterson

    2004-01-01

    In this article, the author synthesizes a collection of scholarship done by, and on, Thomas Jesse Jones and Carter G. Woodson as a source for understanding historical conceptions of citizenship education for African Americans. The author contends that Jones and Woodson played central roles in constructing competing conceptions of citizenship…

  4. Charting the Course: Four Years of the Thomas W. Payzant School on the Move Prize

    Science.gov (United States)

    d'Entremont, Chad; Norton, Jill; Bennett, Michael; Piazza, Peter

    2012-01-01

    Since 2006, the Thomas W. Payzant School on the Move (SOM) Prize has been awarded annually to a Boston public school that has made significant progress in improving student achievement. This case study identifies the structures and strategies that best serve students in prizewinning schools, provides a profile of each of the four winning schools…

  5. E.E.L.K. Peapiiskopi valimised / Thomas Vaga, Ivar Nippak

    Index Scriptorium Estoniae

    Vaga, Thomas, 1938-

    2007-01-01

    21. detsembril teatas häältelugemiskomisjon, et kaks enam hääli saanud kandidaati on Thomas Vaga ja Andres Taul. Samade kandidaatide vahel toimub korduv hääletus. Uued valimismaterjalid saadetakse välja 2007. aasta jaanuaris

  6. Collective excitations of a 87Rb Bose condensate in the Thomas-Fermi regime

    Science.gov (United States)

    Fort, C.; Prevedelli, M.; Minardi, F.; Cataliotti, F. S.; Ricci, L.; Tino, G. M.; Inguscio, M.

    2000-01-01

    Collective excitations have been observed in a 87Rb Bose condensate, confined in a magneto-static, elongated, harmonic trap. We have measured the frequency of two different modes with zero angular momentum along the symmetry axis of the trap. Both the frequencies are in good agreement with the values predicted by the hydrodynamic theory of superfluids holding in the Thomas-Fermi regime.

  7. From pioneering to implementing automated blood pressure measurement in clinical practice: Thomas Pickering's legacy

    DEFF Research Database (Denmark)

    Stolarz-Skrzypek, Katarzyna; Thijs, Lutgarde; Wizner, Barbara

    2010-01-01

    Thomas G. Pickering spent most of his scientific career in carrying out research on clinical hypertension and blood pressure (BP) measurement. In our review of Pickering's seminal work, we first focused on white-coat hypertension and masked hypertension, two terms that he had introduced. Next, we...

  8. 75 FR 36671 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2010-06-28

    ... National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA; Correction AGENCY: National Park Service, Interior. ACTION: Notice... Act (NAGPRA), 25 U.S.C. 3003, of the completion of an inventory of human remains and associated...

  9. St. Thomas and St. John, U.S. Virgin Islands Coastal Digital Elevation Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The 1/3 arc-second St. Thomas and St. John, U.S. Virgin Islands Coastal Digital Elevation Model will be used to support NOAA's tsunami forecast system and for...

  10. "Mens Sana in Corpore Sano": Human Values in Thomas Wilson's "The Arte of Rhetorique."

    Science.gov (United States)

    Luehring, Janet

    In 1553 the work that is touted as the first complete book written in English on rhetoric was published, Thomas Wilson's "Arte of Rhetorique." It became so popular it enjoyed eight printings within its century. Wilson was not a person to translate and read just for knowledge; he believed that knowledge should be imparted to the general…

  11. Chip Frazier named Thomas M. Brooks Professor of Wood Science and Forest Products

    OpenAIRE

    Davis, Lynn

    2007-01-01

    Charles E. "Chip" Frazier of Blacksburg, professor of wood science and forest products in the College of Natural Resources at Virginia Tech, has been appointed the Thomas M. Brooks Professor of Wood Science and Forest Products by the Virginia Tech Board of Visitors during the board's quarterly meeting March 26.

  12. The post-modern scientific thoughts of Thomas Kuhn and Paul ...

    African Journals Online (AJOL)

    Postmodernism is like a spectre hunting the intellectual world, and there is a sense in which the attitude is, first and foremost, against modern science. This essay is, therefore, an expository analysis of the thoughts of Thomas Kuhn and Paul Feyerabend, as classical representations of the postmodern reaction against ...

  13. Fission of hot rotating nuclei: A selfconsistent Thomas-Fermi calculation

    Energy Technology Data Exchange (ETDEWEB)

    Garcias, F.; Barranco, M.; Nemeth, J.; Ngo, C.; Vinas, X.

    1989-05-01

    We have studied the symmetric fission of excited nuclei within an axially deformed Thomas-Fermi model that incorporates selfconsistently the effect of rotation and temperature. We have used a realistic Skyrme force and included up to Planck constant/sup 2/ correction terms in the kinetic energy density.

  14. Planck constant/sup 4/-order Thomas-Fermi variational calculations of finite nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Vinas, X.; Pi, M.; Garcias, F.; Serra, L.; Barranco, M.

    1989-05-01

    We have solved the Planck constant/sup 4/ order Thomas-Fermi equations for external potentials and for nuclear forces of Skyrme type without effective mass. We present some applications to the description of giant resonances and hot systems with especial emphasis in the comparison between different semiclassical methods.

  15. Dalit humanization: A Quest based on M.M. Thomas' theology of salvation and humanization

    NARCIS (Netherlands)

    Rajaiah, J.

    2016-01-01

    Chapter one states the central quest of this thesis: to develop a Dalit theology on the basis of the concepts salvation and humanization of M.M. Thomas. Chapter two elucidates the socio- political and religious milieu which influenced his theology. Thomas’ theology has evolved and developed in

  16. Thomas Merton Goes to Class: Pedagogy on the Borders of the Short Story

    Science.gov (United States)

    Callaghan, Michael J.

    2011-01-01

    Our thesis is more finely tuned to Thomas Merton (1915-68) the writer, more specifically, the poet/artist/writer and thinker. These are the components of the "Merton" voice. Merton senses the quality of innocence as the "sine qua non" of the poet or writer's vocation: "His art depends on an ingrained innocence which he would lose in business, in…

  17. 77 FR 46117 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2012-08-02

    ...-1100-665] Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of... Memorial Washington State Museum (Burke Museum) has completed an inventory of human remains and associated... Museum. Disposition of the human remains and the associated funerary object to the Indian tribes stated...

  18. A Critical Feminist and Race Critique of Thomas Piketty's "Capital in the Twenty-First Century"

    Science.gov (United States)

    Moeller, Kathryn

    2016-01-01

    Thomas Piketty's "Capital in the Twenty-first Century" documents the foreboding nature of rising wealth inequality in the twenty-first century. In an effort to promote a more just and democratic global society and rein in the unfettered accumulation of wealth by the few, Piketty calls for a global progressive annual tax on corporate…

  19. USA saadik loodab võita eestlaste poolehoiu / Joseph M. DeThomas

    Index Scriptorium Estoniae

    DeThomas, Joseph M.

    2003-01-01

    USA suursaadik Eestis Joseph DeThomas vastab on-line intervjuus Eesti Päevalehe lugejate küsimustele Iraagi ründamise, USA ja Euroopa vahelise lõhe, USA Eesti saatkonna võimaliku ümberkolimise kohta

  20. Erindringens poetik. William Wordsworth, S.T. Coleridge, Thomas De Quincey

    DEFF Research Database (Denmark)

    Møller, Lis

    Erindringens poetik tegner et litteratur- og idéhistorisk portræt af erindringen hos tre af den engelske romantiks største forfattere: William Wordsworth, S.T. Coleridge og Thomas De Quincey. I receptionen af de tre digtere, og af romantikken generelt, har erindringsmotivet stået i skyggen af...

  1. The Two Hands of Thomas Aquinas : The Reportationes of the Commentary on Matthew

    NARCIS (Netherlands)

    ten Klooster, Anton

    2014-01-01

    The gospel of Matthew is more important to the theology of Thomas Aquinas than most scholars have realised. Access to his commentary on this gospel is impeded by the lack of a critical edition. Moreover, we have only two reportationes of the text. In order to establish the value of these texts, I

  2. Why heaven kissed earth : the christology of Thomas Goodwin (1600-1680)

    NARCIS (Netherlands)

    Jones, Mark

    2009-01-01

    My dissertation, “Why Heaven Kissed Earth”, looks at the Christology of the Reformed theologian and English Puritan, Thomas Goodwin (1600-1680). The thesis attempts to answer a question first posed by St. Anselm of Cantebury, namely, Cur Deus Homo (“Why did God become man?). Goodwin answers that

  3. Elementary Analysis of the Special Relativistic Combination of Velocities, Wigner Rotation and Thomas Precession

    Science.gov (United States)

    O'Donnell, Kane; Visser, Matt

    2011-01-01

    The purpose of this paper is to provide an elementary introduction to the qualitative and quantitative results of velocity combination in special relativity, including the Wigner rotation and Thomas precession. We utilize only the most familiar tools of special relativity, in arguments presented at three differing levels: (1) utterly elementary,…

  4. some aspects of fisheries ecology in thomas dam, kano nigeria 192

    African Journals Online (AJOL)

    userpc

    SOME ASPECTS OF FISHERIES ECOLOGY IN THOMAS DAM, KANO NIGERIA. 1*Nafiu, S. A., 1Badamasi, I., 2Ahmad, M. K., 1Abdullahi, M. T., 3Yelwa, S. I. and 1Ibrahim,. B.A.. 1Department of Science Laboratory Technology, Kano State Polytechnic, Kano. 2Department of Biological Sciences, Bayero University Kano.

  5. Thomas Merton’s poetics of translation in his letters to writers

    Directory of Open Access Journals (Sweden)

    Marcela María Raggio

    2016-05-01

    Full Text Available This article explores Thomas Merton’s poetics of translation as reflected in his letters to writers. There, Merton expresses his ideas on poetic translation, the methods and the experience of approaching foreign literature through translation. Then, a translation analysis of a sample revises the connection between Merton’s poetics and practice of translation.

  6. Thomas Merton’s poetics of translation in his letters to writers

    OpenAIRE

    Marcela María Raggio

    2016-01-01

    This article explores Thomas Merton’s poetics of translation as reflected in his letters to writers. There, Merton expresses his ideas on poetic translation, the methods and the experience of approaching foreign literature through translation. Then, a translation analysis of a sample revises the connection between Merton’s poetics and practice of translation.

  7. The poor in the Epistle of James and the Gospel of Thomas

    Directory of Open Access Journals (Sweden)

    Patrick J. Hartin

    1997-12-01

    Full Text Available This study explores similarities in the thought world of the Epistle of James and the Gospel of Thomas. Particular attention is devoted to the role that the 'poor' and 'poverty' play in both documents. For the Epistle of James it is 'the poor in the world that God has chosen to be rich in faith and heirs of the kingdom' (Ja 2:5.  In a similar vein, in the Gospel of Thomas the kingdom is promised to those who have embraced the poverty of a radical life-style: 'Blessed are the poor, for yours is the kingdom of heaven' (GTh 54. This outlook betrays a basic ethos adopted toward the world. In both the Epistle of James and the Gospel of Thomas the relationship to the world ultimately determines one's relationship to the kingdom or to God. For the Epistle of James the very definition of religion demands that one keep 'oneself unstained from  the world' (Ja 1 :27 and that 'friendship with the world' is enmity with God (Ja 4:4. For the Gospel of Thomas the rejection of the world involves a radical ethos that embraces an intinerant life ('Be passersby' [GTh 42J, which includes a rejection of wealth (GTh 63.'If you do not abstain from the world, you will not find the kingdom' (GTh 27. It is argued that the Gospel of Thomas and the Epistle of James reflect traditional sayings that endorse a similar ethos of radical discipleship.

  8. Topology Design for Directional Range Extension Networks with Antenna Blockage

    Science.gov (United States)

    2016-11-01

    Topology Design for Directional Range Extension Networks with Antenna Blockage Thomas Shake MIT Lincoln Laboratory shake@ll.mit.edu Abstract...associated electronics into small aircraft to perform such range extension. In particular, the paper examines trade-offs in network topology design...aircraft, and the topology characteristics of the aerial relay network. The analysis suggests that low-degree air topologies such as rings and strings

  9. del Nido versus St. Thomas Cardioplegia Solutions: A Single-Center Retrospective Analysis of Post Cross-Clamp Defibrillation Rates.

    Science.gov (United States)

    Buel, Shane T; Striker, Carrie Whittaker; O'Brien, James E

    2016-06-01

    There are many cardioplegia solutions currently in use for pediatric cardiopulmonary bypass (CPB). The most common being del Nido solution. Another common cardioplegia solution used for pediatric CPB is St. Thomas. In October 2014, Children's Mercy Kansas City changed from the use of modified St. Thomas to del Nido. This study compared rates of post cross-clamp fibrillation requiring defibrillation between del Nido solution and modified St. Thomas solution stratified by weight at Children's Mercy Kansas City. This retrospective study consisted of 394 patients who underwent cardiac surgery requiring cardioplegia between January 1, 2014 and July 31, 2015. The outcome measured was defibrillation upon cross-clamp removal. Statistical significance was determined using Fishers exact test with a two-sided significance level of .05. Incidence of defibrillation post cross-clamp removal was 4.4% in the del Nido group and 26.8% in the St. Thomas group (p defibrillation rates in groups using the del Nido solution. The 0- to 6-kg category had an incidence of fibrillation of 1.23% in the del Nido group and 17.5% in the St. Thomas group (p defibrillation of 1.82% in the del Nido group and 14% in the St. Thomas group (p defibrillation of 8.9% in the del Nido group and 61% in the St. Thomas group (p 60-kg category had an incidence of defibrillation of 16.7% in the del Nido group and 63% in the St. Thomas group (p defibrillation post cross-clamp removal between St. Thomas and del Nido cardioplegia solutions. Analyses of weight stratifications demonstrate a decrease in the rate of defibrillation post cross-clamp removal in all categories within the del Nido group.

  10. Bypassing damaged nervous tissue

    CERN Document Server

    Shneider, M N

    2016-01-01

    We show the principal ability of bypassing damaged demyelinated portions of nervous tissue, thereby restoring its normal function for the passage of action potentials. We carry out a theoretical analysis on the basis of the synchronization mechanism of action potential propagation along a bundle of neurons, proposed recently in [1]. And we discuss the feasibility of implement a bypass to restore damaged nervous tissue and creating an artificial neuron network.

  11. Locality of the Thomas-Fermi-von Weizsäcker Equations

    Science.gov (United States)

    Nazar, F. Q.; Ortner, C.

    2017-06-01

    We establish a pointwise stability estimate for the Thomas-Fermi-von Weiz-säcker (TFW) model, which demonstrates that a local perturbation of a nuclear arrangement results also in a local response in the electron density and electrostatic potential. The proof adapts the arguments for existence and uniqueness of solutions to the TFW equations in the thermodynamic limit by Catto et al. (The mathematical theory of thermodynamic limits: Thomas-Fermi type models. Oxford mathematical monographs. The Clarendon Press, Oxford University Press, New York, 1998). To demonstrate the utility of this combined locality and stability result we derive several consequences, including an exponential convergence rate for the thermodynamic limit, partition of total energy into exponentially localised site energies (and consequently, exponential locality of forces), and generalised and strengthened results on the charge neutrality of local defects.

  12. Nekrasov's Partition Function and Refined Donaldson-Thomas Theory: the Rank One Case

    Directory of Open Access Journals (Sweden)

    Balázs Szendrői

    2012-11-01

    Full Text Available This paper studies geometric engineering, in the simplest possible case of rank one (Abelian gauge theory on the affine plane and the resolved conifold. We recall the identification between Nekrasov's partition function and a version of refined Donaldson-Thomas theory, and study the relationship between the underlying vector spaces. Using a purity result, we identify the vector space underlying refined Donaldson-Thomas theory on the conifold geometry as the exterior space of the space of polynomial functions on the affine plane, with the (Lefschetz SL(2-action on the threefold side being dual to the geometric SL(2-action on the affine plane. We suggest that the exterior space should be a module for the (explicitly not yet known cohomological Hall algebra (algebra of BPS states of the conifold.

  13. Thomas Alva Edison, el más grande inventor y bienhechor de la humanidad

    OpenAIRE

    Arias Arroyo, Gladys C.

    2014-01-01

    Thomas Alva Edison, el más grande inventor, cambió la vida de la gente en todos los lugares del mundo con inventos tales como la luz eléctrica y el fonógrafo. Patentó 1,093 inventos de su creación y mejoró los inventos de muchas otras personas, tales como el teléfono, la máquina de escribir, el generador eléctrico y las imágenes en movimiento. Quizás lo más importante de todo, es que fue el primero en organizar la investigación. Thomas Alva Edison, el más grande inventor, cambió la vida de...

  14. Thomas Edison, le magicien de Menlo Park la vie lumineuse d'un inventeur insatiable

    CERN Document Server

    Reyners, Benjamin; Klein-Scholz, Christelle

    2015-01-01

    Découvrez enfin tout ce qu'il faut savoir sur Thomas Edison et ses inventions en moins d'une heure ! Inventeur de génie, Thomas Edison est aussi l'un des plus prolifiques de tous les temps. Pourtant, rien ne laissait présager un tel destin... Peu scolarisé, il est d'abord vendeur de journaux à 12 ans, puis télégraphiste à 15, avant de devenir l'un des meilleurs ingénieurs de Wall Street à seulement 22 ans. Il ne cesse dès lors d'accumuler les succès. Doté d'une curiosité insatiable et passionné depuis l'enfance par les expériences en tous genres, il crée coup sur coup les plus grandes inventio

  15. Thomas Kuhn's revolutions a historical and an evolutionary philosophy of science?

    CERN Document Server

    Marcum, James A

    2015-01-01

    This new edition of Thomas Kuhn's Revolution marks the 50th anniversary of the publication of Kuhn's most influential work. Drawing on the rich archival sources at MIT, and engaging fully with current scholarship, James Marcum provides the historical background to the development of The Structure of Scientific Revolutions. Exploring the shift Kuhn makes from a historical to an evolutionary philosophy of science and examining Kuhn's legacy in depth, Marcum answers key questions: What exactly was Kuhn's historiographic revolution and how did it come about? Why did it have the impact it did? What will its future impact be for both academia and society? Marcum's answers build a new portrait of Kuhn: his personality, his pedagogical style and the intellectual and social context in which he practiced his trade. Thomas Kuhn's Revolution shows how Kuhn transcends the boundaries of the philosophy of science, influencing sociologists, economists, theologians and even policy makers and politicians. This is a comprehensi...

  16. Thomas-Fermi approximation to pairing in finite Fermi systems. The weak coupling regime

    Energy Technology Data Exchange (ETDEWEB)

    Vinas, X [Departament d' Estructura i Constituents de la Materia and Institut de Ciencies del Cosmos, Facultat de Fisica, Universitat de Barcelona, Diagonal 647, E-08028 Barcelona (Spain); Schuck, P [Institut de Physique Nucleaire, IN2P3-CNRS, Universite Paris-Sud, F-91406 Orsay-Cedex (France); Farine, M, E-mail: xavier@ecm.ub.es [Ecole des Mines de Nantes, Universite Nantes, 4, rue Alfred Kastler B.P. 20722 44307 Nantes-Cedex 3 (France)

    2011-09-16

    We present a new semiclassical theory for describing pairing in finite Fermi systems. It is based on taking the h {yields} 0, i.e. Thomas-Fermi, limit of the gap equation written in the basis of the mean field (weak coupling). In addition to the position dependence of the Fermi momentum, the size dependence of the pairing force is also taken into account in this theory. Along isotopic chains the Thomas-Fermi gaps average the well known arch structure shown by the quantal gaps. This structure can be almost recovered in our formalism if some shell fluctuations are included in the level density. We point out that at the drip line nuclear pairing is strongly reduced. This fact is illustrated with the behaviour of the gap in the inner crust of neutron stars.

  17. Extended Thomas-Fermi approximation to the one-body density matrix

    Energy Technology Data Exchange (ETDEWEB)

    Soubbotin, V.B.; Vinas, X

    2000-02-28

    The one-body density matrix is derived within the Extended Thomas-Fermi approximation. This has been done starting from the Wigner-Kirkwood distribution function for a non-local single-particle potential. The links between this new approximation to the density matrix with former approaches available in the literature are widely discussed. The semiclassical counterpart of the Hartree-Fock energy at the Extended Thomas-Fermi level is also obtained in the case of a non-local one-body Hamiltonian. The semiclassical binding energies and root mean square radii are compared with those obtained using the Strutinsky averaged method. The full Hartree-Fock values are compared with those obtained using the Kohn-Sham scheme based on the different approximations to the density matrix considered in the text. Numerical applications are performed using the Gogny, Brink-Boeker and BDM3Y1{sup *} effective interactions.

  18. Metaphysics as the Science of Essence: E. J. Lowe and Thomas Aquinas

    Directory of Open Access Journals (Sweden)

    Alejandro Pérez

    2013-12-01

    Full Text Available Metaphysics after being ignored for years has returned to the center of the stage in contemporary philosophy. Thomas Aquinas has lived a very similar story, which gave birth to analytical Thomism. Despite the work done in this line of research, the metaphysics of Aquinas has been heavily ignored. However, the metaphysics of Thomas Aquinas has an advantage, little discussed among Thomists and “Tomasinos”, and it is the fact that it is essentialist metaphysics. So, in keeping with the work of metaphysical E. J. Lowe, who presents his metaphysics as “serious essentialist” it is shown here that the metaphysics of Aquinas has the same virtues of “serious essentialism”, which allows to postulate it as a valid and plausible position for contemporary metaphysics.

  19. The infancy Gospel of Thomas: Allegory or myth � Gnostic or Ebionite?

    Directory of Open Access Journals (Sweden)

    A G van Aarde

    2005-10-01

    Full Text Available The aim of this article is to show that scholars assess the Infancy Gospel of Thomas disparagingly as �illogical�, �un-Christian� and �banal�. A more positive judgment is� that it is either �Gnostic� or �purified of Gnosticism�, or merely one of many ancient tales in the form of a historical allegory about Jesus as a child.� The article argues that the author of the Greek version of the Infancy Gospel of Thomas in Codex Sinaiticus (Gr 453 describes the miracles of Jesus in a positive and negative light as if he were an adult.� This phenomenon should be understood against the background that this second-century gospel is presented not so much in the genre of a Gnostic redeemer myth, but rather as a god-child myth that has neither an Orthodox nor a Gnostic orientation. Its context is rather early Ebionite Christianity.

  20. Teamplayer, keine Einzelkämpfer : Thomas Beschorner und Florian Wettstein im Interview

    OpenAIRE

    Beschorner, Thomas; Wettstein, Florian

    2011-01-01

    Wie sieht verantwortliches, unternehmerisches Handeln aus? Warum braucht es ein Institut für Wirtschaftsethik, und wie unterscheiden sich wirtschaftsethische Fragestellungen in den USA von denen in Europa? Prof. Dr. Thomas Beschorner und Prof Dr. Florian Wettstein, die seit diesem Sommer das Institut für Wirtschaftsethik (IWE-HSG) leiten, sprechen im Experten-Interview über den Zusammenghang von Gerechtigkeit und Verantwortung.

  1. Nonexistence in Thomas-Fermi-Dirac-von Weizsäcker Theory with Small Nuclear Charges

    Energy Technology Data Exchange (ETDEWEB)

    Nam, Phan Thành, E-mail: pnam@ist.ac.at [Institute of Science and Technology Austria (Austria); Den Bosch, Hanne Van, E-mail: hannevdbosch@fis.puc.cl [Pontificia Universidad Católica de Chile, Instituto de Física (Chile)

    2017-06-15

    We study the ionization problem in the Thomas-Fermi-Dirac-von Weizsäcker theory for atoms and molecules. We prove the nonexistence of minimizers for the energy functional when the number of electrons is large and the total nuclear charge is small. This nonexistence result also applies to external potentials decaying faster than the Coulomb potential. In the case of arbitrary nuclear charges, we obtain the nonexistence of stable minimizers and radial minimizers.

  2. Briti teadlane: kübersõda ei tule / Thomas Rid ; intervjueerinud Raimo Poom

    Index Scriptorium Estoniae

    Rid, Thomas

    2013-01-01

    Sõjauuringute õppejõud Thomas Rid leiab, et internetis on palju ohte, kuid kübersõda ei ole üks neist. Ridi arvates on äärmiselt ebatõenäoline, et NATO käivitaks kunagi küberrünnaku tõttu 5. artikli. Interneti kõige suuremaks ohustajaks pole NSA, vaid vabadust piirata soovivad autoritaarsed riigid

  3. Social practices transformation: Peter Berger’s and Thomas Luckmann’s theory in crisis society

    OpenAIRE

    E. D. Osipova

    2015-01-01

    The article is devoted to Peter Berger’s and Thomas Luckmann’s theory of the construction of reality in the context of social practices transformation in the risk society. According to this theory, daily routine appears to be the basis of social reality that is interpreted as the result of the interaction processes. The article considers the fundamental procedures of the social reality construction - institutionalization and legitimization; such an analysis proves the famous sociologists idea...

  4. Physician/chemist/geologist: Charles Thomas Jackson's life of conflict and controversy

    Science.gov (United States)

    Landa, E.R.

    1995-01-01

    After a brief medical career, Charles Thomas Jackson (1805-1880) began work as a consulting chemist and geologist in Boston. He serves as State Geologist in Maine, Rhode Island, and New Hampshire from 1837 to 1884, and completed geological surveys of those States. In 1847, he was appointed United States Geologist to undertake a survey of the public lands of the Lake Superior region of Michigan. This survey was beset by strife, and Jackson was forced to resign in 1849. -from Author

  5. Thomas H. Shepard, M.D., pioneer in embryology and teratology.

    Science.gov (United States)

    Fantel, Alan G; Polifka, Janine E; Oakley, Godfrey P

    2017-06-01

    Dr. Thomas H. Shepard died on October 3, 2016 at the age of 93. He was a major figure in the fields of teratology, embryonic and fetal pathology, and pediatrics. He was beloved by his colleagues as he was by the many students and fellows whom he taught, mentored and befriended. His contributions to teratology are extraordinary and he is greatly missed. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  6. A Strange Case of Hero-Worship: John Mitchel and Thomas Carlyle

    OpenAIRE

    Michael Huggins

    2013-01-01

    The Scottish essayist Thomas Carlyle might be considered a surprising influence on the Young Ireland movement of the 1840s and its most militant leader, John Mitchel. Carlyle has become notorious for his anti-Irish sentiments, expressed most forcefully in his Reminiscences of my Irish journey in 1849. Yet his critique of the Benthamite and liberal Zeitgeist was a significant influence on Mitchel. This article examines what it was in Carlyle’s thought that appealed to Mitchel. Carlyle’s antago...

  7. All But Forgotten: Thomas Jefferson's Contribution to the Development of Public Administration in the United States

    OpenAIRE

    Newbold, Stephanie P

    2006-01-01

    Thomas Jefferson's contribution to the development of public administration in the United States has been largely neglected. When we think of Jefferson our minds naturally reflect back to his authorship of the Declaration of American Independence, his commitment to religious freedom, his unwavering support for universal education at all levels of instruction, his establishment of the University of Virginia, and his public service as Foreign Minister to France, Secretary of State, Vice Presid...

  8. Thomas Mann: Vascular Fatal Illness of the Writer Who Mastered Disease Through Literary Fiction.

    Science.gov (United States)

    Silvestri, Valeria

    2018-01-01

    Ruptured iliac artery may initially clinically mimic an isolated inferior limb venous involvement. It was indeed an acute iliac artery dissection complicated by contained rupture and misdiagnosed as inferior limb venous thrombosis that led to the death of Thomas Mann in 1955. The details of the complex case are analyzed. Considerations of medical interest and on actuality of his work are also added. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Thomas Mann e a cena intelectual no Brasil: encontros e desencontros

    Directory of Open Access Journals (Sweden)

    Sibele Paulino

    2009-12-01

    Full Text Available A origem brasileira de Thomas Mann, por parte de sua mãe, Julia da Silva Bruhns, deu ocasião, na maturidade do escritor, a seu contato com intelectuais brasileiros ou estrangeiros ligados à cena cultural do Brasil. No primeiro grupo, tem-se Gilberto Freyre, Sérgio Buarque de Holanda e Erico Verissimo. Residentes no Brasil, Karl Lustig-Prean, que posteriormente retornará à Europa, e o tradutor Herbert Caro, que se radica em definitivo no Brasil. Também o contato direto ou indireto com pensadores e escritores como Karl Loewenstein, Heinrich Eduard Jacob, Marte Brill e Stefan Zweig colaboraram para a aproximação de Thomas Mann ao universo brasileiro. Estes e outros pontos de contato são descritos no presente artigo, que pretende difundir dados e documentos há muito inacessíveis ou inéditos, no sentido de contribuir com abordagens atualizadas da obra de Thomas Mann e oferecer à pesquisa especializada a indicação de dados biográficos e documentais relacionados ao escritor, no que concerne à sua relação com o Brasil.

  10. The mask of Thomas Mann (1875-1955): medical insights and last illness.

    Science.gov (United States)

    Carter, R

    1998-02-01

    Thomas Mann, German novelist and essayist, was awarded the Nobel Prize for literature in 1929 for his masterpiece, The Buddenbrooks, aided by his much acclaimed The Magic Mountain, which depicts life in a tuberculosis sanitorium. One of the most medically perceptive writers of the century, Mann was obsessed by illness and disease and produced works that reflect penetrating observation of medicine. When Hitler seized power, Mann fled Germany and entered Switzerland in forced exile. Mann later moved to the United States, becoming an American citizen in 1944. He became embroiled in political turmoil during the red-baiting era; disenchanted with this country, he returned to Switzerland in 1952 and died in Zürich in 1955. This vignette lifts the veil revealing the Mann behind the mask, tormented by life-long homoerotic tendencies that were confirmed by his unexpurgated diaries, published in 1979. I interviewed Professor Christoph Hedinger, who performed the autopsy on Thomas Mann. Professor Hedinger's protocol formed the primary source material for this study and clarified the exact cause of the Nobelist's death. Magisterial, with robust self-regard, Thomas Mann led a life that lends itself as a great human interest story. He was a highly intelligent, complex person whose sexual inversion provides some insight into the person but is irrelevant in assessing his artistic achievements. Mann's defiant stance against the Nazis and his masterful contributions to world literature assure him an enduring and unassailable role in world history.

  11. Ethics in the medieval university: the importance of classics reading for the elaboration of Thomas Aquinas

    Directory of Open Access Journals (Sweden)

    Tatyana Murer Cavalcante

    2012-05-01

    Full Text Available This paper aims to present some considerations about the importance of reading to the development of the ethics conceptions of Thomas Aquinas (1224 - 5? / 1274. At the dawn of the thirteenth century, the townspeople of Medieval West created a new institution designed for knowledge and education: the University. In it, teachers and disciples were debating key issues for the new society using mainly texts of Ancient Philosophy and Christians, but also Arab and Jewish writings. The literacy forms used encompassed mainly lectio and disputatio , and counteracted by distinct theoretical bases, those thinkers eventually recreated the summa , in a original and fundamental form to the philosophical elaboration of that time. To discuss the importance of reading in the formulation of the concept of ethics in the medieval university, we will present some characteristics of the production of knowledge in the thirteenth century linked to its historical context and then discuss some ethical considerations of Thomas Aquinas, one of the most prominent authors of that period. Considering the limits of this article, only one text, “The object of charity” based on Aquinas major work, the Summa of Theology, will be discussed in depth. Preliminarily, it is possible to state that as well as the reading of classical authors by Thomas Aquinas and other masters of the thirteenth century, helped them develop knowledge about ethics conforming to their time, historical reading of these authors helps in the understanding of today.

  12. Combined Use of Tissue Morphology, Neural Network Analysis of Chromatin Texture and Clinical Variables to Predict Prostate Cancer Agressiveness from Biopsy Water

    National Research Council Canada - National Science Library

    Partin, Alan

    2000-01-01

    Purpose: To combine clinical, serum, pathologic and computer derived information into an artificial neural network to develop/validate a model to predict prostate cancer tumor aggressiveness in both a...

  13. Combined Use of Tissue Morphology, Neural Network Analysis of Chromatin Texture & Clinical Variables to Predict Prostate Cancer Agressiveness from Biopsy Material

    National Research Council Canada - National Science Library

    Partin, Alan

    1999-01-01

    the purpose of this report is to combine clinical, serum, pathological and computer derived information into an artificial neural network to develop/validate a model to predict prostate cancer tumor...

  14. NOAA ESRI Geotiff- 1m Bathymetry of St. Thomas, US Virgin Islands, 2004, UTM 20 WGS84

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains an ESRI Geotiff with 1 meter cell size representing the bathymetry of the south shore of St. Thomas, US Virgin Islands.NOAA's NOS/NCCOS/CCMA...

  15. GeoTIFF of 3x3 m Bathymetry for St. Thomas & St. John, 2011, UTM 20N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a LiDAR (Light Detection & Ranging) 3x3 meter resolution bathymetric surface for an area of shallow seabed surrounding St. Thomas and St....

  16. EAARL-B Submerged Topography–—Saint Thomas, U.S. Virgin Islands, 2014

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — ASCII XYZ point cloud data for a portion of the submerged environs of Saint Thomas, U.S. Virgin Islands, was produced from remotely sensed, geographically referenced...

  17. Zooplankton data collected from THOMAS G. THOMPSON in Arabian Sea; 18 September 1994 to 27 December 1995 (NODC Accession 9800077)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Zooplankton data were collected using zooplankton net casts in Arabian Sea from THOMAS G. THOMPSON. Data were collected from 18 September 1994 to 27 December 1995 by...

  18. NOBLE, Thomas F. X. Images, iconoclasm, and the carolingians. Filadélfia: University of Pennsylvania Press, 2009, 488 p

    DEFF Research Database (Denmark)

    Petersen, Nils Holger

    2011-01-01

    A review and contextualization (concerning music writing in the ninth century) of Thomas F. Noble's magisterial account of the iconoclastic controversy in the eighth and ninth centuries and its impact in the Carolingian kingdom (and empire) in the same period....

  19. Thomas Crombez, Luk van den Dries (eds., Mass Theatre in Interwar Europe: Flanders and the Netherlands in an International Perspective

    Directory of Open Access Journals (Sweden)

    Maartje Abbenhuis

    2015-09-01

    Full Text Available Thomas Crombez, Luk van den Dries (eds., Mass Theatre in Interwar Europe: Flanders and the Netherlands in an International Perspective (Leuven: Universitaire pers Leuven, 2014, 164 pp., ISBN 978 90 5867 992 5.

  20. Oceanographic profile data collected from CTD casts aboard Thomas Jefferson Launch 3101 and Thomas Jefferson Launch 3102 as part of project OPR-B370-TJ-15 in the North Atlantic Ocean from 2014-05-01 to 2014-10-30 (NCEI Accession 0148756)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0148756 includes physical and profile data collected aboard the Thomas Jefferson Launch 3101 and Thomas Jefferson Launch 3102 during project...

  1. The modified Thomas test is not a valid measure of hip extension unless pelvic tilt is controlled.

    Science.gov (United States)

    Vigotsky, Andrew D; Lehman, Gregory J; Beardsley, Chris; Contreras, Bret; Chung, Bryan; Feser, Erin H

    2016-01-01

    The modified Thomas test was developed to assess the presence of hip flexion contracture and to measure hip extensibility. Despite its widespread use, to the authors' knowledge, its criterion reference validity has not yet been investigated. The purpose of this study was to assess the criterion reference validity of the modified Thomas test for measuring peak hip extension angle and hip extension deficits, as defined by the hip not being able to extend to 0º, or neutral. Twenty-nine healthy college students (age = 22.00 ± 3.80 years; height = 1.71 ± 0.09 m; body mass = 70.00 ± 15.60 kg) were recruited for this study. Bland-Altman plots revealed poor validity for the modified Thomas test's ability to measure hip extension, which could not be explained by differences in hip flexion ability alone. The modified Thomas test displayed a sensitivity of 31.82% (95% CI [13.86-54.87]) and a specificity of 57.14% (95% CI [18.41-90.10]) for testing hip extension deficits. It appears, however, that by controlling pelvic tilt, much of this variance can be accounted for (r = 0.98). When pelvic tilt is not controlled, the modified Thomas test displays poor criterion reference validity and, as per previous studies, poor reliability. However, when pelvic tilt is controlled, the modified Thomas test appears to be a valid test for evaluating peak hip extension angle.

  2. The modified Thomas test is not a valid measure of hip extension unless pelvic tilt is controlled

    Directory of Open Access Journals (Sweden)

    Andrew D. Vigotsky

    2016-08-01

    Full Text Available The modified Thomas test was developed to assess the presence of hip flexion contracture and to measure hip extensibility. Despite its widespread use, to the authors’ knowledge, its criterion reference validity has not yet been investigated. The purpose of this study was to assess the criterion reference validity of the modified Thomas test for measuring peak hip extension angle and hip extension deficits, as defined by the hip not being able to extend to 0º, or neutral. Twenty-nine healthy college students (age = 22.00 ± 3.80 years; height = 1.71 ± 0.09 m; body mass = 70.00 ± 15.60 kg were recruited for this study. Bland–Altman plots revealed poor validity for the modified Thomas test’s ability to measure hip extension, which could not be explained by differences in hip flexion ability alone. The modified Thomas test displayed a sensitivity of 31.82% (95% CI [13.86–54.87] and a specificity of 57.14% (95% CI [18.41–90.10] for testing hip extension deficits. It appears, however, that by controlling pelvic tilt, much of this variance can be accounted for (r = 0.98. When pelvic tilt is not controlled, the modified Thomas test displays poor criterion reference validity and, as per previous studies, poor reliability. However, when pelvic tilt is controlled, the modified Thomas test appears to be a valid test for evaluating peak hip extension angle.

  3. Thomas Piketty

    DEFF Research Database (Denmark)

    Rendtorff, Jacob Dahl; Larsen, Øjvind

    2014-01-01

    Piketty’s book, Capital in the Twenty-First Century (2014) has become a bestseller in the world. Two month after its publication, it had sold more than 200.000 copies, and this success will surely continue for a long time. Piketty has established a new platform to discuss political economy....

  4. Classification of Laser Induced Fluorescence Spectra from Normal and Malignant bladder tissues using Learning Vector Quantization Neural Network in Bladder Cancer Diagnosis

    DEFF Research Database (Denmark)

    Karemore, Gopal Raghunath; Mascarenhas, Kim Komal; Patil, Choudhary

    2008-01-01

    In the present work we discuss the potential of recently developed classification algorithm, Learning Vector Quantization (LVQ), for the analysis of Laser Induced Fluorescence (LIF) Spectra, recorded from normal and malignant bladder tissue samples. The algorithm is prototype based and inherently...

  5. Cognitive Radio for Tactical Wireless Communication Networks

    Science.gov (United States)

    2011-10-09

    12:10:41 6 Michael B. Pursley, Thomas C. Royster. Adaptive-rate nonbinary LDPC coding for frequency-hop communications, MILCOM 2008 - 2008 IEEE...interference in a frequency-hop (FH) packet radio network. Performance results are given in [PuR08] for irregular low-density parity-check ( LDPC ) codes in...FH spread-spectrum systems with nonbinary orthogonal modulation. Two adaptive LDPC coding protocols are devised and evaluated. Each employs

  6. Comparison Study for Whitney (Raviart-Thomas)-Type Source Models in Finite-Element-Method-Based EEG Forward Modeling.

    Science.gov (United States)

    Bauer, Martin; Pursiainen, Sampsa; Vorwerk, Johannes; Kostler, Harald; Wolters, Carsten H

    2015-11-01

    This study concentrates on finite-element-method (FEM)-based electroencephalography (EEG) forward simulation in which the electric potential evoked by neural activity in the brain is to be calculated at the surface of the head. The main advantage of the FEM is that it allows realistic modeling of tissue conductivity inhomogeneity. However, it is not straightforward to apply the classical model of a dipolar source with the FEM, due to its strong singularity and the resulting irregularity. The focus of this study is on comparing different methods to cope with this problem. In particular, we evaluate the accuracy of Whitney (Raviart-Thomas)-type dipole-like source currents compared to two reference dipole modeling methods: the St. Venant and partial integration approach. Common to all these methods is that they enable direct approximation of the potential field utilizing linear basis functions. In the present context, Whitney elements are particularly interesting, as they provide a simple means to model a divergence-conforming primary current vector field satisfying the square integrability condition. Our results show that a Whitney-type source model can provide simulation accuracy comparable to the present reference methods. It can lead to superior accuracy under optimized conditions with respect to both source location and orientation in a tetrahedral mesh. For random source orientations, the St. Venant approach turns out to be the method of choice over the interpolated version of the Whitney model. The overall moderate differences obtained suggest that practical aspects, such as the focality, should be prioritized when choosing a source model.

  7. Donaldson-Thomas Invariants of 2-Dimensional sheaves inside threefolds and modular forms

    DEFF Research Database (Denmark)

    Gholampour, Amin; Sheshmani, Artan

    2018-01-01

    Motivated by the S-duality conjecture, we study the Donaldson-Thomas invariants of the 2 dimensional Gieseker stable sheaves on a threefold. These sheaves are supported on the fibers of a nonsingular threefold X fibered over a nonsingular curve. In the case where X is a K3 fibration, we express t...... these invariants in terms of the Euler characteristic of the Hilbert scheme of points on the K3 fiber and the Noether-Lefschetz numbers of the fibration. We prove that a certain generating function of these invariants is a vector modular form of weight -3/2 as predicted in S-duality....

  8. Shaping the Living Body: paradigms of soma and authority in Thomas Hanna’s writings

    Directory of Open Access Journals (Sweden)

    Margherita De

    2014-12-01

    Full Text Available This article outlines some features of the discursive strategies adopted by Thomas Hanna in order to legitimate Somatics – as well as his own method – in the eyes of the scientific community. The notion of soma and the representations of its functions will be recognized at the core of this issue. In order to stress the enduring risk of dogmatism of the scientific rhetoric to our days, as well as their influence on the configuration of somatic discourses, I will be mainly referring to Isabelle Ginot’s radical epistemology and Martha Eddy’s critical perspective.

  9. Modified Thomas splint-cast combination for the management of limb fractures in small equids

    DEFF Research Database (Denmark)

    Ladefoged, Søren; Grulke, Sigrid; Busoni, V.

    2017-01-01

    Objective: To describe the management and outcome of limb fractures in small domestic equids treated with a modified Thomas splint-cast combination (MTSCC). Study Design: Retrospective case series. Animals: Client owned horses and donkeys. Methods: Medical records, including radiographs, were...... reviewed for details of animals diagnosed with a limb fracture and treated by external coaptation using a MTSCC (2001-2012). Follow-up >6 months after discharge was obtained via telephone consultation with owners or veterinarians. Results: Nine horses and 4 donkeys were identified with fractures...

  10. Extended Thomas-Fermi density functionals in the presence of a tensor interaction in spherical symmetry

    Science.gov (United States)

    Bartel, J.; Bencheikh, K.; Meyer, J.

    2008-02-01

    For a one-body Hamiltonian obtained from the energy-density functional associated with a Skyrme effective interaction, including a tensor force, semiclassical functional densities are derived in the framework of the Extended Thomas-Fermi method, in spherical symmetry, for the kinetic energy and spin-orbit density. The structure of the self-consistent mean-field potentials constructed with such semiclassical functionals is studied. The impact of the tensor force in particular on the spin-orbit form factor clearly indicates the necessity of including such tensor-force terms in the theoretical description of atomic nuclei and their possible influence on the shell structure of exotic nuclei.

  11. Profiles in medical courage: Thomas Kummet and the courage to fight burearcracy

    Directory of Open Access Journals (Sweden)

    Robbins RA

    2013-01-01

    Full Text Available Thomas Kummet was an oncologist wrongly accused in his mind of delivering substandard care. His fight for correcting what he believed to be a mistake illustrates the difficulty physicians face when challenging the current peer review system. In an attempt to defend his reputation he filed suit which was eventually dismissed by a Federal Court. His frustration over the futility of his fight is illustrative of the difficulties many physicians have faced in fighting a large bureaucracy and an unsympathetic justice system.

  12. GUERRA E PAZ NA TEORIA POLÍTICA DE THOMAS HOBBES

    Directory of Open Access Journals (Sweden)

    Lígia Pavan Baptista

    2014-08-01

    Full Text Available Este artigo tem o objetivo de analisar em que medida a teoria política moderna, tal como apresentada por Thomas Hobbes, expondo um novo paradigma na análise de questões como a origem do Estado e do poder político, assim como, definindo, por meio de metodologia científica, conceitos tais como guerra, paz, soberania, justiça, igualdade e liberdade, podem estabelecer as raízes de questões das relações internacionais, apesar de não ser o principal objetivo do autor.

  13. An essay concerning human understanding: how the cerebri anatome of Thomas Willis influenced John Locke.

    Science.gov (United States)

    Lega, Bradley C

    2006-03-01

    Neurosurgeons are familiar with the anatomic investigations of Thomas Willis, but his intellectual legacy actually extends into the arena of philosophy. John Locke was a student of Willis while at Oxford, and this essay explores how some of Willis's anatomic discoveries might have influenced the ideas Locke expressed in his Essay Concerning Human Understanding. It also includes historical information about 17th century England and the group of men (including Christopher Wren and Robert Boyle) who worked with Willis and founded the Oxford Experimental Philosophy Club, which became the Royal Society.

  14. Thomas Scharping, Birth Control in China, 1949-2000. Population policy and demographic development

    OpenAIRE

    Allès, Élisabeth

    2007-01-01

    Family policy and the growth of the population in China have been the subject of continuous attention for many years, but there was no research which provided an overall view of the policies and outcomes for these areas. This remarkable work by the German demographer Thomas Scharping, on birth control and demography in China from 1949 to 2000, fills this gap. It recounts and analyses demographic growth, the policies of the Chinese state in this field and the reactions of the population over t...

  15. Relativistic Thomas-Fermi description of collective modes in droplets of nuclear matter

    Energy Technology Data Exchange (ETDEWEB)

    da Providencia, C.; Brito, L.; da Providencia, J. [Centro de Fisica Teorica, Universidade de Coimbra, 3000 - Coimbra (Portugal); Nielsen, M. [Instituto de Fisica, Universidade de Sao Paulo, Caixa Postal 66318 - 5389-970 Sao Paulo, Sao Paulo (Brazil); Vinas, X. [Department ECM, Facultat de Fisica, Universitat de Barcelona, Diagonal 647, E-08028 Barcelona (Spain)

    1996-11-01

    Isoscalar collective modes in a relativistic meson-nucleon system are investigated in the framework of the time-dependent Thomas-Fermi method. The energies of the collective modes are determined by solving consistently the dispersion relations and the boundary conditions. The energy weighted sum rule satisfied by the models considered allows the identification of the giant resonances. The percentage of the energy weighted sum rule exhausted by the collective modes is in agreement with experimental data, but the agreement with the energy of the modes depends on the model considered. {copyright} {ital 1996 The American Physical Society.}

  16. Thomas J. Sugrue, Not even Past. Barack Obama and the Burden of Race.

    OpenAIRE

    Wekker, Gloria

    2010-01-01

    With the title “Not even Past,” historian and sociologist Thomas J. Sugrue alludes to a motto used by Barack Obama in his most famous speech “A more perfect union,” held in Philadelphia on March 18, 2008, when, pressured by the uproar around the sermons of his pastor, the Reverend Jeremiah Wright, he positioned himself with regard to race. Obama himself borrowed the phrase from William Faulkner, who wrote “The past is not dead. In fact, it’s not even past.” The title also serves as an apt ban...

  17. Elementary analysis of the special relativistic combination of velocities, Wigner rotation and Thomas precession

    Energy Technology Data Exchange (ETDEWEB)

    O' Donnell, Kane; Visser, Matt, E-mail: kco61@uclive.ac.nz, E-mail: matt.visser@msor.vuw.ac.nz [School of Mathematics, Statistics, and Operations Research, Victoria University of Wellington, Wellington (New Zealand)

    2011-07-15

    The purpose of this paper is to provide an elementary introduction to the qualitative and quantitative results of velocity combination in special relativity, including the Wigner rotation and Thomas precession. We utilize only the most familiar tools of special relativity, in arguments presented at three differing levels: (1) utterly elementary, which will suit a first course in relativity; (2) intermediate, to suit a second course; and (3) advanced, to suit higher level students. We then give a summary of useful results and suggest further reading in this often obscure field.

  18. Edward Gantt (1742-1837): US senate chaplain and first White House physician to Thomas Jefferson.

    Science.gov (United States)

    Cavanagh, Harrison Dwight

    2017-08-01

    In his long and eventful life, Edward Gantt (1742-1837) made important contributions to the newly independent American Republic, as well as to the development of scientific evidence-based American medicine. Unfortunately, his achievements have gone unrecognized and unreported in mainstream historical publications. Specifically, his service as the first designated White House doctor, and personal physician to President Thomas Jefferson from 1801 to 1809 has not been reported. The purpose of this paper is to document the biographical and scientific details of his extraordinary life and notable contributions.

  19. Thomas Merton: itinerarium da vida contemplativa no tempo e na história

    OpenAIRE

    Pereira, Sibélius Cefas

    2012-01-01

    O trabalho propõe-se a aprofundar o tema da vida contemplativa em Thomas Merton, reconhecendo que a categoria contemplação, mais do que um tema foi um eixo em torno do qual girou toda a sua obra. A tese central é a de que Merton reinaugura um caminho místico e contemplativo de busca e encontro com Deus no tempo e na história. A Realidade divina e a realidade humana como realidades convergentes. Na primeira parte abordou-se o tema da contemplação como experiência de plenitude de vida em três d...

  20. Argumen Eksistensi Tuhan Dalam Metafisika Ibn Rusyd Dan St. Thomas Aquinas

    Directory of Open Access Journals (Sweden)

    Wardani Wardani

    2015-06-01

    Full Text Available Abstract : To establish an argumentation for the existence of God is properly the most crucial as well as complicated effort in the life of religion and faith of human being. There are various approaches and methods have been applicated to reach it by theologians, thinkers, and scientists, including philosophers with their demonstrative-philosophical method. Some arguments which were initiated by Aristotle are ones of the most popular and have been adopted and improved as well by many thinkers and philosophers after him, some arguments which proposed by Ibn Rusyd and St. Thomas Aquinas with some modifications and improvisations are the best examples of it. In the case of elaboration and analysis toward those arguments for the existence of God, this article attempts to compare between metaphysical thought of Ibn Rushd (well-known in the West as Averroës and St. Thomas Aquinas. There is no doubt that both are Aristotelian in their philosophy. Therefore, to seek the similarities and differences, and to analyze the influence of Aristotle on their modes of thought, especially in argumentation for the existence of God, are an urgent point in the way to find more stronger and relevant arguments.Keywords: argument of creation (dalīl al-ikhtirā`, teleological argument (dalīl al-‘ināyah, unmoved mover, prime cause, influence, parallelism.Abstrak : Menggagas argumentasi tentang eksistensi Tuhan sejatinya merupakan upaya yang paling krusial sekaligus pelik dalam kehidupan beragama dan kepercayaan umat manusia. Berbagai pendekatan dan metode telah ditempuh untuk meraihnya oleh para teolog, pemikir, dan ilmuwan, termasuk para filsuf dengan pendekatan dan metode demonstratif-filosofisnya. Argumen-argumen yang diprakarsai oleh Aristoteles adalah diantara yang paling populer dan telah diadopsi serta dikembangkan oleh para pemikir dan filsuf setelahnya, tak terkecuali argumen-argumen yang Ibn Rusyd dan St. Thomas Aquinas kemukakan dengan segenap modifikasi

  1. Thomas J. Sugrue, Not even Past. Barack Obama and the Burden of Race.

    Directory of Open Access Journals (Sweden)

    Gloria Wekker

    2010-11-01

    Full Text Available With the title “Not even Past,” historian and sociologist Thomas J. Sugrue alludes to a motto used by Barack Obama in his most famous speech “A more perfect union,” held in Philadelphia on March 18, 2008, when, pressured by the uproar around the sermons of his pastor, the Reverend Jeremiah Wright, he positioned himself with regard to race. Obama himself borrowed the phrase from William Faulkner, who wrote “The past is not dead. In fact, it’s not even past.” The title also serves as an apt ban...

  2. Thomas Digges and Giordano Bruno: 400 Years of Plurality of Worlds

    Science.gov (United States)

    Corbally, C. J.

    1999-05-01

    Some four hundred years ago was the fascinating era when modern astronomy began. Its ``beginning" came with the establishment of the heliocentric universe in people's minds. From Nicolaus Copernicus, through Thomas Digges, to Giordano Bruno we can trace how the Copernican system progressed to the idea of an infinite universe, and how this gave birth to a new tradition in thinking about the plurality of worlds. While this progression does not appear to have been by direct encounter between the principal players, the vision of one was incorporated into the thought of the next. Such progression in our understanding of the universe continues today -- and presumably tomorrow.

  3. Thermal contribution to thermodynamic functions in the Thomas-Fermi model

    Energy Technology Data Exchange (ETDEWEB)

    Shemyakin, O P; Levashov, P R; Obruchkova, L R; Khishchenko, K V, E-mail: shemyakin@ihed.ras.r [Joint Institute for High Temperatures, Russian Academy of Sciences, Izhorskaya 13 Bldg 2, Moscow 125412 (Russian Federation)

    2010-08-20

    We propose a method of calculation of thermodynamic functions in the Thomas-Fermi model at finite temperature {theta}. Expressions for first and second derivatives of the free energy are analytically obtained in the framework of the model. A special treatment of thermodynamic functions at low temperatures is provided by asymptotic series expansion at {theta} {yields} 0. A special algorithm is used to ensure required accuracy for all values in a wide range of volumes and temperatures. We compare the results of our computations with ideal Boltzmann and Fermi gas models.

  4. Tissue tests

    NARCIS (Netherlands)

    Sonneveld, C.; Voogt, W.

    2009-01-01

    Tissue tests are widely used in horticulture practice and have in comparison with soil or substrate testing advantages as well disadvantages in comparison with soil testing. One of the main advantages of tissue tests is the certainty that analysed nutrients in plant tissues are really present in the

  5. Self-Securing Network Interfaces: What, Why and How?

    Science.gov (United States)

    2002-05-01

    G. Anagnostakis, William A. Arbaugh, Angelos D. Keromytis, and Jonathan M. Smith. The price of safety in an active network. MS–CIS–99–04. Depart- ment...of Computer and Information Science, University of Pennsylvania, 1999. [4] Thomas E. Anderson, David E. Culler , and David A. Patterson. A case for...NOW (networks of workstations). IEEE Micro, 15(1):54–64, February 1995. [5] William A. Arbaugh, David J. Farber, and Jonathan M. Smith. A secure and

  6. Topology Optimization for Energy Management in Underwater Sensor Networks

    Science.gov (United States)

    2015-02-01

    and communication. This multi-objective cost functional leads to non-dominant optimization. Such a problem is formulated as a Pareto -optimal trade...K. Jha1 Thomas A. Wettergren2 Asok Ray1 Kushal Mukherjee3 Keywords: Underwater Sensor Network, Energy Management, Pareto Optimization, Adaptation...communication models for under- water environment. The approximate Pareto -optimal surface is obtained as a trade-off between network lifetime and probability

  7. Tissue segmentation-assisted analysis of fMRI for human motor response: an approach combining artificial neural network and fuzzy C means

    OpenAIRE

    Chiu, MJ; Lin, CC; Chuang, KH; Chen, JH; Huang, KM

    2001-01-01

    The authors have developed an automated algorithm for segmentation of magnetic resonance images (MRI) of the human brain. They investigated the quantitative analysis of tissue-specific human motor response through an approach combining gradient echo functional MRI and automated segmentation analysis. Fifteen healthy volunteers, placed in a 1.5 T clinical MR imager, performed a self-paced finger opposition throughout the activation periods. T1-weighted images (WI), T2WI, and proton density WI ...

  8. Tissue segmentation-assisted analysis of fMRI for human motor response: an approach combining artificial neural network and fuzzy C means.

    Science.gov (United States)

    Chiu, M J; Lin, C C; Chuang, K H; Chen, J H; Huang, K M

    2001-03-01

    The authors have developed an automated algorithm for segmentation of magnetic resonance images (MRI) of the human brain. They investigated the quantitative analysis of tissue-specific human motor response through an approach combining gradient echo functional MRI and automated segmentation analysis. Fifteen healthy volunteers, placed in a 1.5 T clinical MR imager, performed a self-paced finger opposition throughout the activation periods. T1-weighted images (WI), T2WI, and proton density WI were acquired for segmentation analysis. Single-slice axial T2* fast low-angle shot (FLASH) images were obtained during the functional study. Pixelwise cross-correlation analysis was performed to obtain an activation map. A cascaded algorithm, combining Kohonen feature maps and fuzzy C means, was applied for segmentation. After processing, masks for gray matter, white matter, small vessels, and large vessels were generated. Tissue-specific analysis showed a signal change rate of 4.53% in gray matter, 2.98% in white matter, 5.79% in small vessels, and 7.24% in large vessels. Different temporal patterns as well as different levels of activation were identified in the functional response from various types of tissue. High correlation exists between cortical gray matter and subcortical white matter (r = 0.957), while the vessel behaves somewhat different temporally. The cortical gray matter fits best to the assumed input function (r = 0.957) followed by subcortical white matter (r = 0.829) and vessels (r = 0.726). The automated algorithm of tissue-specific analysis thus can assist functional MRI studies with different modalities of response in different brain regions.

  9. Military Transformation and the Defense Industry After Next: The Defense Industrial Implications of Network-Centric Warfare

    Science.gov (United States)

    2002-09-01

    and Manuel Castells , The Rise of the Network Society, 2nd ed. (Oxford: Blackwell, 2000). For popular treatments, see Thomas L. Friedman, The Lexus and...American Military Styles in Strategy and Analysis. Bal- timore: Johns Hopkins University Press, 1989. Castells , Manuel . The Rise of the Network Soci- ety

  10. Cutting the Gordian knot of world poverty: Thomas Pogge’s Alexandrian solution

    Directory of Open Access Journals (Sweden)

    Konjović Marko

    2014-01-01

    Full Text Available In this paper, the author analyzes Thomas Pogge’s thesis that citizens of affluent countries are violating the negative right of the global poor not to be harmed by lending their support to the current global institutional order. The author argues, however, that Pogge’s argument is unsatisfactory because he makes an unjustified leap from collective to individual responsibility. The author begins by assessing Pogge’s argument so as to elucidate the leap. Subsequently, the author examines two proposals which could complete his argument; nonetheless, the author argues that both proposals are unsatisfactory. The first suggestion - the participation argument - contains two conceptual inadequacies; moreover, if we were to accept this argument, we would also be committed to accepting an unsavory implication. Taking cue from Thomas Nagel’s „rule in our name“ argument, the author develops Pogge’s second suggestion - the political representation argument - that promises to bridge the gap in Pogge’s thinking. The issues of misrepresentation and of underrepresentation, however, undermine this proposal too.

  11. The conversion of the cardinal? Pride and penitence in some Tudor histories of Thomas Wolsey

    Directory of Open Access Journals (Sweden)

    Patrick Hornbeck

    2016-05-01

    Full Text Available The life of Cardinal Thomas Wolsey, lord chancellor of England from 1515 to 1529, has inspired no small number of literary, historical, and dramatic retellings. A comprehensive study of these texts remains to be written, but this article seeks to make a start by examining how Tudor writers portrayed the cardinal’s response to his deposition and subsequent disgrace. For some authors, Wolsey’s fall only made him more proud, and he began to act erratically and disloyally, confirming the wisdom of the king’s decision to relieve him of office. For others, deposition moved Wolsey to become philosophical and penitent, and some such writers depict a cardinal who at the end of his life underwent nothing short of a conversion. This article traces both of these historiographical trajectories from their origins in writings of the late 1540s and 1550s through a range of late Tudor chronicle accounts. Elements of both narratives about the cardinal appear, prominently if not always congruously, in one of the best-known theatrical works about the events of the reign of Henry VIII, the play King Henry VIII (All Is True by William Shakespeare and John Fletcher. Understanding the interrelationships between the Tudor texts presented here is essential to grasping later portrayals of Wolsey and his contemporaries. Keywords: Thomas Wolsey; Henry VIII; English Reformation; conversion; historiography

  12. Globe Event | Lecture by Hervé Dessimoz and Thomas Büchi | 14 May

    CERN Multimedia

    Globe Info

    2013-01-01

    At the summit of Sustainable Development, by Hervé Dessimoz and Thomas Büchi.   Globe de la science et de l'innovation Route de Meyrin, 1211 Genève Tuesday 14 May 2013 at 8:30 p.m. The lecture will be in French Refuge du Goûter. Hervé Dessimoz and Thomas Büchi have been committed to sustainable development since the 2000s. They created the Palais de l’Équilibre at Expo.02. They designed an exhibition in conjunction with the Cité de la Science et de l’Industrie (Paris) to educate visitors about sustainable development. The pavilion was donated to CERN by the Swiss Confederation and rebuilt on the CERN site in 2004. It is now known as the Globe of Science and Innovation. The Refuge du Goûter, on the slopes of Mont Blanc, is the culmination of their research into sustainable development, with the aim of demonstrating that if we can construct a building at 3835 m which is a...

  13. The «Heterenomy» of Kantian Will. A Comparison with Thomas Aquinas

    Directory of Open Access Journals (Sweden)

    María Elton

    2013-05-01

    Full Text Available The Kantian ideal is to establish a rational foundation of morality, accessible to everybody, independently of each own religiuos beliefs or even in absence of these beliefs. However, the Kantian practical reason does not ultimately fulfill this ideal, because the subject must have rational faith in the existence of God in order to promote its object, the supreme good, that is, the union between morality and its proportional happiness. God is the cause of this harmony in the afterlife. The cause of this reason’s «heteronomy» is precisely Kant’s foundation of the autonomy of will. At the bottom of this problem lies the question of how moral law influences man’s desire in order that his reason could be really practical. Thomas Aquinas has this problem resolved thanks to his metaphysical anthropology. According to Thomas, the origin of human acts resides in the agent, who moves himself for an end not only known, but also desired, being thus the owner of his actions with a kind of «personal autonomy»

  14. The conversion of the cardinal? Pride and penitence in some Tudor histories of Thomas Wolsey

    Directory of Open Access Journals (Sweden)

    Patrick Hornbeck

    2016-02-01

    Full Text Available The life of Cardinal Thomas Wolsey, lord chancellor of England from 1515 to 1529, has inspired no small number of literary, historical, and dramatic retellings. A comprehensive study of these texts remains to be written, but this article seeks to make a start by examining how Tudor writers portrayed the cardinal’s response to his deposition and subsequent disgrace. For some authors, Wolsey’s fall only made him more proud, and he began to act erratically and disloyally, confirming the wisdom of the king’s decision to relieve him of office. For others, deposition moved Wolsey to become philosophical and penitent, and some such writers depict a cardinal who at the end of his life underwent nothing short of a conversion. This article traces both of these historiographical trajectories from their origins in writings of the late 1540s and 1550s through a range of late Tudor chronicle accounts. Elements of both narratives about the cardinal appear, prominently if not always congruously, in one of the best-known theatrical works about the events of the reign of Henry VIII, the play King Henry VIII (All Is True by William Shakespeare and John Fletcher. Understanding the interrelationships between the Tudor texts presented here is essential to grasping later portrayals of Wolsey and his contemporaries.Keywords: Thomas Wolsey; Henry VIII; English Reformation; conversion; historiography

  15. Wind Power Opportunities in St. Thomas, USVI: A Site-Specific Evaluation and Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Lantz, E.; Warren, A.; Roberts, J. O.; Gevorgian, V.

    2012-09-01

    This NREL technical report utilizes a development framework originated by NREL and known by the acronym SROPTTC to assist the U.S. Virgin Islands in identifying and understanding concrete opportunities for wind power development in the territory. The report covers each of the seven components of the SROPTTC framework: Site, Resource, Off-take, Permitting, Technology, Team, and Capital as they apply to wind power in the USVI and specifically to a site in Bovoni, St. Thomas. The report concludes that Bovoni peninsula is a strong candidate for utility-scale wind generation in the territory. It represents a reasonable compromise in terms of wind resource, distance from residences, and developable terrain. Hurricane risk and variable terrain on the peninsula and on potential equipment transport routes add technical and logistical challenges but do not appear to represent insurmountable barriers. In addition, integration of wind power into the St. Thomas power system will present operational challenges, but based on experience in other islanded power systems, there are reasonable solutions for addressing these challenges.

  16. From pioneering to implementing automated blood pressure measurement in clinical practice: Thomas Pickering's legacy

    DEFF Research Database (Denmark)

    Stolarz-Skrzypek, Katarzyna; Thijs, Lutgarde; Wizner, Barbara

    2010-01-01

    Thomas G. Pickering spent most of his scientific career in carrying out research on clinical hypertension and blood pressure (BP) measurement. In our review of Pickering's seminal work, we first focused on white-coat hypertension and masked hypertension, two terms that he had introduced. Next, we...... involving white-coat hypertension and masked hypertension, diurnal BP variability, and self-measured BP. Recent studies validated Pickering's observations in terms of cardiovascular outcome and bridged the path from concept to application in clinical practice....... highlighted the early publications of Pickering on diurnal BP variability and on the clinical application of self-measured BP. Pickering's work inspired many investigators worldwide and constituted a solid basis for further research. Pickering's original ideas led to algorithms for risk stratification......Thomas G. Pickering spent most of his scientific career in carrying out research on clinical hypertension and blood pressure (BP) measurement. In our review of Pickering's seminal work, we first focused on white-coat hypertension and masked hypertension, two terms that he had introduced. Next, we...

  17. Thomas Mann, leitor de Goethe: O fardo da naturalidade em Viagem à Itália e Morte em Veneza

    Directory of Open Access Journals (Sweden)

    Pedro Caldas

    2007-04-01

    Full Text Available Este ensaio pretende compreender o papel da idéia de naturalidade na moderna cultura literária alemã. Para chegar a este objetivo, faremos a comparação entre Viagem à Itália, de Goethe, e Morte em Veneza, de Thomas Mann, de modo a ficar claro que, através da representação de Veneza (Itália, feita por Thomas Mann, podemos identificar, baseados na teoria da influência desenvolvida por Harold Bloom, uma concepção de artista que revela a interpretação de Thomas Mann a respeito dos dilemas da cultura alemã.

  18. EXISTENCE AS «THE HIGHEST PERFECTION AMONG OF ALL PERFECTIONS» IN THOMAS AQUINE’S PHILOSOPHY

    Directory of Open Access Journals (Sweden)

    V. KOVREVSKAYA

    2008-11-01

    Full Text Available There is a tradition in the history of philosophy to perceive the concept of being (esse in the language of Thomas Aquinas mainly as actuality, real existence without paying proper attention to the texts, where being is described as «the highest perfection» and «the perfection of all perfections», that is especially in the latest works of Thomas Aquinas. The «existential» interpretation of Aquinas is also incorrect. Being in Thomas Aquinas is a complex, multilevel and analogical concept. It is applied to the world, man and God not in the same meaning, but analogically. Being in minimum is merely exist-ing, universal connection of all and everything, universal world base. Being in maxi-mum is the absolute plenitude and perfection of the Creator.

  19. Tissue types (image)

    Science.gov (United States)

    ... are 4 basic types of tissue: connective tissue, epithelial tissue, muscle tissue, and nervous tissue. Connective tissue supports ... binds them together (bone, blood, and lymph tissues). Epithelial tissue provides a covering (skin, the linings of the ...

  20. Topology Management Algorithms for Large Scale Aerial High Capacity Directional Networks

    Science.gov (United States)

    2016-11-01

    Topology Management Algorithms for Large-Scale Aerial High Capacity Directional Networks Joy Wang, Thomas Shake, Patricia Deutsch, Andrea Coyle, Bow...airborne backbone network is large- scale topology management of directional links in a dynamic environment. In this paper, we present several... topology manage- ment algorithms for large scale airborne networks and evaluate the performance of these algorithms under various scenarios. In each case

  1. In vivo genome-wide analysis of multiple tissues identifies gene regulatory networks, novel functions and downstream regulatory genes for Bapx1 and its co-regulation with Sox9 in the mammalian vertebral column.

    Science.gov (United States)

    Chatterjee, Sumantra; Sivakamasundari, V; Yap, Sook Peng; Kraus, Petra; Kumar, Vibhor; Xing, Xing; Lim, Siew Lan; Sng, Joel; Prabhakar, Shyam; Lufkin, Thomas

    2014-12-05

    Vertebrate organogenesis is a highly complex process involving sequential cascades of transcription factor activation or repression. Interestingly a single developmental control gene can occasionally be essential for the morphogenesis and differentiation of tissues and organs arising from vastly disparate embryological lineages. Here we elucidated the role of the mammalian homeobox gene Bapx1 during the embryogenesis of five distinct organs at E12.5 - vertebral column, spleen, gut, forelimb and hindlimb - using expression profiling of sorted wildtype and mutant cells combined with genome wide binding site analysis. Furthermore we analyzed the development of the vertebral column at the molecular level by combining transcriptional profiling and genome wide binding data for Bapx1 with similarly generated data sets for Sox9 to assemble a detailed gene regulatory network revealing genes previously not reported to be controlled by either of these two transcription factors. The gene regulatory network appears to control cell fate decisions and morphogenesis in the vertebral column along with the prevention of premature chondrocyte differentiation thus providing a detailed molecular view of vertebral column development.

  2. La suerte de un clásico: el caso de Thomas Humphrey Marshall

    Directory of Open Access Journals (Sweden)

    Rafael Silva Vega

    2014-06-01

    Full Text Available Este artículo tiene como propósito fundamental revisitar el clásico ensayo “Ciudadanía y clase social” de Thomas Humphrey Marshall, publicado por primera vez en 1950. El objetivode este trabajo consiste en escrutar cuáles pueden ser los aportes o contribuciones de Marshall a los problemas de la ciudadanía en las sociedades actuales. En este sentido, la pregunta que se quiere responder es si Marshall y su obra tienen un espacio en los debates actuales sobre la ciudadanía, pese a que estos están siendo dominados por problemas de frontera tales como la participación política, el reconocimiento, la construcción de identidades,la diferencia y discriminación cultural o de género.

  3. Thomas Kuhn: Hacia una metateoría unificada de la ciencia

    Directory of Open Access Journals (Sweden)

    Estany, Anna

    1998-04-01

    Full Text Available Not available.La muerte de Thomas Kuhn el verano de 1996 ha supuesto una pérdida para la comunidad filosófica y científica. Kuhn propuso una teoría sobre las revoluciones científicas en su obra La estructura de las revoluciones científicas, publicada en 1962. El aspecto más novedoso de la obra de Kuhn es su propuesta de un análisis global de la ciencia, teniendo en cuenta tanto los factores internos como externos. Una buena parte de las corrientes en filosofía de la ciencia que en la última década se han desarrollado están presentes en la obra de Kuhn.

  4. Thomas Paytherus (1752-1828): Entrepreneurial surgeon-apothecary and ardent Jennerian.

    Science.gov (United States)

    Connor, Henry; Clark, David M

    2013-08-01

    Thomas Paytherus was born in Fownhope and apprenticed in Gloucester. He practised there and in Ross-on-Wye where he and Edward Jenner undertook an autopsy on a patient with angina that they linked causally to coronary artery ossification. In 1794 Paytherus moved to London and opened a highly successful pharmacy that he later sold to his partners Savory and Moore. Paytherus was among those who advised Jenner on the publication of his work on vaccination. Then he acted as an intermediary in the dispute between Jenner and Ingen-Housz and also alerted Jenner to Pearson's claims as a pioneer of vaccination. In 1800 he published a detailed analysis of the dispute between Jenner and Woodville whose patients had developed variola-like lesions following vaccination. Their correspondence shows that Paytherus, Jenner and their families remained firm friends. Paytherus and his family moved to Abergavenny where he died in 1828.

  5. A Utopia de Thomas More e o destino de sua leitura em seus 500 anos

    Directory of Open Access Journals (Sweden)

    Gleyton Trindade

    2016-11-01

    Full Text Available Este artigo procura analisar o significado da obra Utopia de Thomas More passados 500 anos de sua publicação. Adotando um ponto de vista crítico em relação as leituras liberais desta obra, o artigo procura destacar os avanços do que estamos designando como leituras republicanas em seu esforço de inserir a obra de More nos debates de seu tempo. Concluímos que a grande contribuição da Utopia para pensar os desafios do mundo político, inclusive no mundo contemporâneo, não no que ela prefiguraria de um possível regime totalitário, mas na necessidade de refletir sobre as condições da constituição de uma república de homens livres.

  6. Thomas Hardy and His Readers: Contradictions of the Rebellious Serial Writer

    Directory of Open Access Journals (Sweden)

    Adelina Sánchez Espinosa

    2016-12-01

    Full Text Available This contribution explores the relationship between Thomas Hardy and his contemporary readers from The Poor Man and the Lady, his first, unpublished, novel, to The Well- Beloved, his last one. It discovers a writer split into two, with Hardy, the artist, striving to cohabitate with Hardy-the serial writer for the three decades his career as a novelist lasted. In order to fully appreciate Hardy's novels as they have reached us nowadays, after the 1912 Wessex edition, we should focus on the contradictions between their initial manuscripts, their edited versions for the family magazines and their final reconstructions into volume forms. Although Hardy certainly wanted quick success with the Victorian masses he never let go of his "higher aspirations" to be received differently by a more select readership, even if this alternative reading had to be done between the lines at a later stage.

  7. The structure of scientific revolutions, according to Thomas Kuhn, on the analysis of art history

    Directory of Open Access Journals (Sweden)

    María Eugenia Rabadán Villalpando

    2017-07-01

    Full Text Available This article offers some solutions to problems relating to the theory and methodology of a particular piece of research into modern and contemporary landscaping. It concerns the dynamic processes of theoretical, epistemological and formal changes in the visual arts in the 20th and 21st centuries. The analysis, based on the structuralism of scientific revolutions first published by Thomas Kuhn, offers some answers to the debate on the articulation of paradigms in the history of science, according to Kuhn, instead of the articulation of styles in art history, according to Heinrich Wölfflin, Meyer Shapiro and Ernst Gombrich, among others, considering science and art as entities of a different nature. Kuhn’s approach to art history, particularly to the work of Gombrich, leads us to draw a parallel between science and art in Kuhn’s work, where he attempted to articulate paradigms in art history.

  8. The African Well Woman's Clinic at Guy's and St Thomas' Hospital Trust.

    Science.gov (United States)

    Momoh, C

    1998-03-01

    In September 1997, the Guy's and St. Thomas' Hospital Trust opened its African Well Woman's Clinic to provide counseling and support to pregnant survivors of female genital mutilation. The clinic offers deinfibulation to women at 18-20 weeks' gestation. The clinic is operated by a qualified specialist midwife with the support of a female obstetrician/gynecologist. While it is only open the first Monday of every month, the clinic has already served 33 infibulated immigrants from Somalia, one from Ethiopia, three from Sudan, and three from Eritrea. In addition, the clinic has seen five women from Nigeria and four from Sierra Leone with clitoridectomy. A December 1997 survey conducted by clinic staff revealed that health care workers felt they needed more information about female genital mutilation. Therefore, the clinic organizes lectures for medical and midwifery students and other health care workers.

  9. Notas de la Dirección: Dr. Thomas Harper Goodspeed

    Directory of Open Access Journals (Sweden)

    Revista Caldasia

    1946-08-01

    Full Text Available Invitado de manera especial por el Ministerio de Educación y la Universidad Nacional, visito recientemente a Bogotá el distinguido profesor Dr. Thomas Harper Goodspeed, director del Jardín Botánico de la Universidad de California, en compañia de su esposa, la señora Florence de Goodspeed. Nuestro ilustre huésped es bien conocido en el mundo científico por sus estudios sobre Citología y Genética y sus profundas investigaciones en el genero Nicotiana, así como por su dirección de las expediciones botánicas enviadas por la Universidad de California a los Andes, desde Colombia hasta la Tierra del Fuego.

  10. Super-size caricature: Thomas Rowlandson's Place des Victoires at the Society of Artists in 1783

    Directory of Open Access Journals (Sweden)

    Kate Grandjouan

    2016-11-01

    Full Text Available This article re-examines an ambitious caricature of the French that Thomas Rowlandson (1757–1827 exhibited in London in 1783. Recent research has confirmed that the artist undertook training at the Académie Royale in Paris while still a student at the Royal Academy in London. In the following essay, I argue that this double professional route into comic art can be related to his conception of the Place des Victoires. The broader context for this discussion is provided by several ideas that have been important to recent histories of British art, notably the rise of the public exhibition and the vigorous market for caricature prints. As what I call a “super-size” caricature, the drawing highlights how comic art could take on dimensions and appearances that suited exhibition contexts.

  11. Scaling calculation of isoscalar giant resonances in relativistic Thomas-Fermi theory

    Energy Technology Data Exchange (ETDEWEB)

    Patra, S.K.; Vinas, X.; Centelles, M. E-mail: mario@ecm.ub.es; Del Estal, M

    2002-05-20

    We derive analytical expressions for the excitation energy of the isoscalar giant monopole and quadrupole resonances in finite nuclei, by using the scaling method and the extended Thomas-Fermi approach to relativistic mean-field theory. We study the ability of several nonlinear {sigma}-{omega} parameter sets of common use in reproducing the experimental data. For monopole oscillations the calculations agree better with experiment when the nuclear matter incompressibility of the relativistic interaction lies in the range 220-260 MeV. The breathing-mode energies of the scaling method compare satisfactorily with those obtained in relativistic RPA and time-dependent mean-field calculations. For quadrupole oscillations, all the analyzed nonlinear parameter sets reproduce the empirical trends reasonably well.

  12. A brief history of macular grids: from Thomas Reid to Edvard Munch and Marc Amsler.

    Science.gov (United States)

    Marmor, M F

    2000-01-01

    Metamorphopsia is a symptom of retinal distortion from intrinsic retinal disease. It has undoubtedly been experienced for millennia, but its clinical significance has been appreciated only in modern times. The Norwegian painter Edvard Munch recognized scotomas and metamorphopsia after suffering an intraocular hemorrhage in his 60th year. Drawings made during this illness show his changing perceptions, and also his attempts to document them with a grid of lines. The Scottish philosopher Thomas Reid may have been the first to write about metamorphopsia. He described distortion of his vision in 1764, after an episode of sungazing, and recognized that the problem was probably of retinal origin. Lines or grids to document metamorphopsia have appeared in ophthalmology textbooks for more than 100 years, but testing for macular degeneration did not become routine until the dissemination of Amsler's grids in the middle of the 20th century. This is in large measure a result of developments in ophthalmology that made therapy for macular disease possible.

  13. Perish, then publish: Thomas Harriot and the sine law of refraction.

    Science.gov (United States)

    Fishman, R S

    2000-03-01

    A talented young scientist, Thomas Harriot, wrote the first English account of the New World, "A Briefe and True Report of the New Found Land of Virginia," distinguished by its serious effort to describe and understand the American Indian. Harriot went on to make innovations in mathematics and was one of the first astronomers to use the telescope. His largely unappreciated contribution to the history of ophthalmology was the first formulation of the sine law of refraction of light, found in his unpublished papers long after his death in 1621. Willebrord Snell discovered the sine law in Holland in 1621 but also died without formally publishing it. Rene Descartes first published the sine law in 1637. The sine law of refraction became not only the prime law of all lens systems but ushered in a new world of physical laws.

  14. FILSAFAT ILMU KARL R. POPPER DAN THOMAS S. KUHN SERTA IMPLIKASINYA DALAM PENGAJARAN ILMU

    Directory of Open Access Journals (Sweden)

    Slamet Subekti

    2016-04-01

    Full Text Available This article discusses about philosophy of science according to Karl R. Popper and Thomas S. Kuhn. There are similarities and differences between their views about how progress and what function of science.Apparently both Popper and Kuhn agree that science does not proceed by induction. However Kuhn disagrees with the view that science progresses by falsifiability through conjectures and refutations, but occurance by paradigm shift. Popper and Kuhn’s disagreement amounted to a distinction between two functions within the practice of science, one of criticism (Popper and one of puzzle solving (Kuhn.Science education implies the teaching and learning of science interesting and fruitful in one hand, and teachers should be role models to students in the other hand

  15. Hermeneutic and Teleology in Ethics across Denominations—Thomas Aquinas and Karl Barth

    Directory of Open Access Journals (Sweden)

    Jacqueline Stewart

    2017-09-01

    Full Text Available This study arises from the context of current debates in the Catholic Church on the place of rule and law in moral reasoning. I suggest that ethics may be best served by approaches that place the human subject in a teleogical context and that recognise the need for interpretation of circumstances surrounding actions to be evaluated. This is in contrast to normative rule approaches. The insights retrieved from the account of moral reasoning in Thomas Aquinas by Joseph Selling are compared with an account of the ethical implications of Karl Barth’s theology of hope as expressed in Volume Four of the Church Dogmatics. It is concluded that, in an ecumenical convergence, neither propose a normative rule approach. Rather both use a teleological context and require a hermeneutic of evaluation.

  16. Towards a Wise Despotism: Traces of Thomas Carlyle in the BBC North and South (2004

    Directory of Open Access Journals (Sweden)

    Mark Wallace

    2012-12-01

    Full Text Available Thomas Carlyle was among the most influential writers in the English language during the 19th century, but is now ostensibly absent from cultural memory. Nevertheless, his ideas may be seen to live on indirectly in the works of the writers he influenced, one of whom is Elizabeth Gaskell. The 2004 adaptation of Gaskell’s North and South provides an instance of a modern approach to Carlylean ideas embodied in the source text. The adaptation finds itself in dialogue with Carlylean notions of heroism and leadership, modifying these notions for acceptance with a 21st century audience. The treatment of the Carlylean content of Gaskell’s novel is both revealing of socio-political ideals latent in modern audiences and a demonstration of the transmission and transmutation of ideologies through narrative and across media.

  17. David Thomas: Out in the Redwoods, Documenting Gay, Lesbian, Bisexual, Transgender History at the University of California, Santa Cruz, 1965-2003

    OpenAIRE

    Reti, Irene H.; Thomas, David

    2004-01-01

    David Thomas was interviewed on November 8, 2001 at the Regional History office in McHenry Library. Thomas was a professor of politics at UCSC from 1966 to 1999. He taught Sexual Politics: Gay Politics , the first regular gay course taught by a faculty member at UCSC, and one of the first in the United States.

  18. Biological aspects and life table of Uroleucon ambrosiae (Thomas, 1878 as a function of temperature

    Directory of Open Access Journals (Sweden)

    Auad Alexander Machado

    2003-01-01

    Full Text Available The aphid Uroleucon ambrosiae (Thomas is considered a pest of hidroponically-grown lettuce, but basic and applied information on its control are scarce in Brazil. The aim of this study was to determine the effect of different temperatures on biological aspects and life history of U. ambrosiae (Thomas developing on hydroponic lettuce (Lactuca sativa L. crop. Newly emerged nymphs were placed on 4-cm discs of hydroponic lettuce, var. Verônica, which were maintained on 5-cm Petri dishes, at temperatures of 15, 20 and 25ºC and 14 h photophase, and inside a greenhouse, within micro-cages at room temperature. The duration of development in all nymphal stages varied inversely to temperature. Nymphs maintained at 20ºC and 25ºC, had similar development period. However, at fluctuating greenhouse temperatures (daily mean = 21ºC, different results were obtained, which was also true for the pre-reproductive, reproductive and post-reproductive periods. Daily and total fertilities at 20ºC were better in comparison to the other treatments. The highest mortality rate of aphids occurred under greenhouse conditions. The production of 1.28 nymphs per female per day, the time needed for the population to double in size (TD=2.77days, and the intrinsic rate of population increase (r m=0.25, were similar for in insects maintained at 20 and 25ºC. On the other hand, time interval between generations (T and the net reproductive rate (Ro were higher at 20ºC. In the greenhouse, even though T was similar to laboratory conditions at 20 and 25ºC, the R0, r m and l parameters were lower and TD was higher. Based on biological aspects, fertility and life expectancy tables, constant temperature of 20ºC is the most suitable for U. ambrosiae.

  19. Integration versus apartheid in post-Roman Britain: a response to Thomas et Al. (2008).

    Science.gov (United States)

    Pattison, John E

    2011-12-01

    The genetic surveys of the population of Britain conducted by Weale et al. and Capelli et al. produced estimates of the Germani immigration into Britain during the early Anglo-Saxon period, c.430-c.730. These estimates are considerably higher than the estimates of archaeologists. A possible explanation suggests that an apartheid-like social system existed in the early Anglo-Saxon kingdoms resulting in the Germani breeding more quickly than the Britons. Thomas et al. attempted to model this suggestion and showed that it was a possible explanation if all Anglo-Saxon kingdoms had such a system for up to 400 years. I noted that their explanation ignored the probability that Germani have been arriving in Britain for at least the past three millennia, including Belgae and Roman soldiers, and not only during the early Anglo-Saxon period. I produced a population model for Britain taking into account this long term, low level migration that showed that the estimates could be reconciled without the need for introducing an apartheid-like system. In turn, Thomas et al. responded, criticizing my model and arguments, which they considered persuasively written but wanting in terms of methodology, data sources, underlying assumptions, and application. Here, I respond in detail to those criticisms and argue that it is still unnecessary to introduce an apartheid-like system in order to reconcile the different estimates of Germani arrivals. A point of confusion is that geneticists are interested in ancestry, while archaeologists are interested in ethnicity: it is the bones, not the burial rites, which are important in the present context.

  20. Gene network and pathway analysis of bovine mammary tissue challenged with Streptococcus uberis reveals induction of cell proliferation and inhibition of PPARγ signaling as potential mechanism for the negative relationships between immune response and lipid metabolism

    Directory of Open Access Journals (Sweden)

    Rodriguez-Zas Sandra L

    2009-11-01

    Full Text Available Abstract Background Information generated via microarrays might uncover interactions between the mammary gland and Streptococcus uberis (S. uberis that could help identify control measures for the prevention and spread of S. uberis mastitis, as well as improve overall animal health and welfare, and decrease economic losses to dairy farmers. The main objective of this study was to determine the most affected gene networks and pathways in mammary tissue in response to an intramammary infection (IMI with S. uberis and relate these with other physiological measurements associated with immune and/or metabolic responses to mastitis challenge with S. uberis O140J. Results Streptococcus uberis IMI resulted in 2,102 (1,939 annotated differentially expressed genes (DEG. Within this set of DEG, we uncovered 20 significantly enriched canonical pathways (with 20 to 61 genes each, the majority of which were signaling pathways. Among the most inhibited were LXR/RXR Signaling and PPARα/RXRα Signaling. Pathways activated by IMI were IL-10 Signaling and IL-6 Signaling which likely reflected counter mechanisms of mammary tissue to respond to infection. Of the 2,102 DEG, 1,082 were up-regulated during IMI and were primarily involved with the immune response, e.g., IL6, TNF, IL8, IL10, SELL, LYZ, and SAA3. Genes down-regulated (1,020 included those associated with milk fat synthesis, e.g., LPIN1, LPL, CD36, and BTN1A1. Network analysis of DEG indicated that TNF had positive relationships with genes involved with immune system function (e.g., CD14, IL8, IL1B, and TLR2 and negative relationships with genes involved with lipid metabolism (e.g., GPAM, SCD, FABP4, CD36, and LPL and antioxidant activity (SOD1. Conclusion Results provided novel information into the early signaling and metabolic pathways in mammary tissue that are associated with the innate immune response to S. uberis infection. Our study indicated that IMI challenge with S. uberis (strain O140J elicited

  1. Tissue Classification

    DEFF Research Database (Denmark)

    Van Leemput, Koen; Puonti, Oula

    2015-01-01

    Computational methods for automatically segmenting magnetic resonance images of the brain have seen tremendous advances in recent years. So-called tissue classification techniques, aimed at extracting the three main brain tissue classes (white matter, gray matter, and cerebrospinal fluid), are now...... well established. In their simplest form, these methods classify voxels independently based on their intensity alone, although much more sophisticated models are typically used in practice. This article aims to give an overview of often-used computational techniques for brain tissue classification...

  2. Bioprinting: Functional droplet networks

    Science.gov (United States)

    Durmus, Naside Gozde; Tasoglu, Savas; Demirci, Utkan

    2013-06-01

    Tissue-mimicking printed networks of droplets separated by lipid bilayers that can be functionalized with membrane proteins are able to spontaneously fold and transmit electrical currents along predefined paths.

  3. Livets febrile hemmeligheder. Et litterært slægtskab mellem Henrik Pontoppidan og Thomas Mann

    DEFF Research Database (Denmark)

    Vangshardt, Rasmus

    filosofferne Arthur Schopenhauer og Friedrich Nietzsche – og med Thomas Mann. Det giver samtidig anledning til en revurdering af De Dødes Riges slutning: Siden bogens udgivelse har litterater diskuteret, hvorvidt dens slut-utopi er beundringsværdig eller tynd. Men Livets febrile hemmeligheder påpeger noget...

  4. "Vältimatud nuhtlused" : August Komendant, Louis I. Kahn ja arhitektuuri ning insenerikunsti keerulised suhted / Thomas Leslie

    Index Scriptorium Estoniae

    Leslie, Thomas

    2006-01-01

    Artikkel põhineb Thomas Leslie Kuressaares Louis Kahni päevadel peetud ettekandel. Louis Kahni koostöös August Komendandiga projekteeritud hoonetest pikemalt Richardsi Meditsiiniliste Uuringute laboratooriumist, Salki bioloogianistituudist (1959-1965, La Jolla, Kalifornia) ja Kimbelli kunstimuuseumist (1966-1972, Texas, Fort Worth). Bibl. lk. 75

  5. Thomas Edison State College and Colorado State University: Using Cutting-Edge Technology to Enhance CE Unit Success

    Science.gov (United States)

    van Zyl, Henry; Powell, Albert, Jr.

    2012-01-01

    Thomas Edison State College (TESC) and Colorado State University (CSU) offer significant contrasts in institutional culture, student demographics, faculty and institutional priorities and approaches to distance education course development and delivery. This article offers case studies showing that widely disparate program design and delivery…

  6. A farewell to Dr Thomas Knacker (* 29.04.1951 - 30.10.2011): scientific contributions and personal memories

    DEFF Research Database (Denmark)

    Römbke, Jörg; Coors, Anja; Fenner, Kathrin

    2012-01-01

    On October 30, 2011 we lost Dr. Thomas Knacker, a much valued and loved colleague, research partner and friend. We deeply regret the loss of an internationally honoured ecotoxicologist. The colleagues and friends that wish to express their sorrow in this contribution include individuals from...

  7. Psychiatrists' assessments of mental illness. A comparison of some aspects of Thomas Scheff's approach to labelling theory.

    Science.gov (United States)

    Bean, P

    1979-08-01

    The labelling theory of mental illness and particularly that version formulated by Thomas Scheff has been applied to psychiatry. Studies completed by Scheff have produced considerable evidence to support labelling theory. An attempt is made here to determine to what extent labelling theory applies to a group of British psychiatrists. The results give little support to Scheff's position.

  8. Thomas DaCosta Kaufmann and Michael North (eds., Mediating Netherlandish Art and Material Culture in Asia

    Directory of Open Access Journals (Sweden)

    Claartje Rasterhoff

    2015-12-01

    Full Text Available Book notice of: Thomas DaCosta Kaufmann and Michael North (eds., Mediating Netherlandish Art and Material Culture in Asia (Amsterdam Studies in the Dutch Golden Age Amsterdam, Amsterdam University Press, 2014. 348 pp. ISBN 978-90-8964-569-2. € 99,00.

  9. Electrostatic interactions between ions near Thomas-Fermi substrates and the surface energy of ionic crystal at imperfect metals

    Science.gov (United States)

    Kaiser, V.; Comtet, J.; Niguès, A.; Siria, A.; Coasne, B.; Bocquet, L.

    2017-01-01

    The electrostatic interaction between two charged particles is strongly modified in the vicinity of a metal. This situation is usually accounted for by the celebrated image charges approach, which was further extended to account for the electronic screening properties of the metal at the level of the Thomas-Fermi description. In this paper we build upon the approach by [Kornyshev et al. Zh. Eksp. Teor. Fiz., 78(3):1008–1019, 1980] and successive works to calculate the 1-body and 2-body electrostatic energy of ions near a metal in terms of the Thomas-Fermi screening length. We propose workable approximations suitable for molecular simulations of ionic systems close to metallic walls. Furthermore, we use this framework to calculate analytically the electrostatic contribution to the surface energy of a one dimensional crystal at a metallic wall and its dependence on the Thomas-Fermi screening length. These calculations provide a simple interpretation for the surface energy in terms of image charges, which allow for an estimate of interfacial properties in more complex situations of a disordered ionic liquid close to a metal surface. A counterintuitive outcome is that electronic screening, as characterized by a molecular Thomas-Fermi length ℓTF, profoundly affects the wetting of ionic systems close to a metal, in line with the recent experimental observation of capillary freezing of ionic liquids in metallic confinement. PMID:28436506

  10. Electrostatic interactions between ions near Thomas-Fermi substrates and the surface energy of ionic crystals at imperfect metals.

    Science.gov (United States)

    Kaiser, V; Comtet, J; Niguès, A; Siria, A; Coasne, B; Bocquet, L

    2017-07-01

    The electrostatic interaction between two charged particles is strongly modified in the vicinity of a metal. This situation is usually accounted for by the celebrated image charges approach, which was further extended to account for the electronic screening properties of the metal at the level of the Thomas-Fermi description. In this paper we build upon a previous approach [M. A. Vorotyntsev and A. A. Kornyshev, Zh. Eksp. Teor. Fiz., 1980, 78(3), 1008-1019] and successive works to calculate the 1-body and 2-body electrostatic energy of ions near a metal in terms of the Thomas-Fermi screening length. We propose workable approximations suitable for molecular simulations of ionic systems close to metallic walls. Furthermore, we use this framework to calculate analytically the electrostatic contribution to the surface energy of a one dimensional crystal at a metallic wall and its dependence on the Thomas-Fermi screening length. These calculations provide a simple interpretation for the surface energy in terms of image charges, which allows for an estimation of the interfacial properties in more complex situations of a disordered ionic liquid close to a metal surface. The counter-intuitive outcome is that electronic screening, as characterized by a molecular Thomas-Fermi length lTF, profoundly affects the wetting of ionic systems close to a metal, in line with the recent experimental observation of capillary freezing of ionic liquids in metallic confinement.

  11. Lübecki filmipäevad 1999 ja Thomas Manni ekraniseering 1923 / Lauri Kärk

    Index Scriptorium Estoniae

    Kärk, Lauri, 1954-

    1999-01-01

    4.-7. novembrini Lübeckis toimunud Põhjamaade filmipäevade 41. Nordische Filmtage huvitavamatest filmidest, nagu Thomas Manni "Buddenbrookide" ekraniseering 1923. aastast (režissöör Gerhard Lamprecht) ja Rasmus Gerlachi dokumentaal "Operaator Kaufman" Dziga Vertovist ja tema kahest, samuti kino alal tegutsenud vennast

  12. Rotation of the swing plane of Foucault's pendulum and Thomas spin precession: two sides of one coin

    Energy Technology Data Exchange (ETDEWEB)

    Krivoruchenko, Mikhail I [Alikhanov Institute for Theoretical and Experimental Physics, Russian Federation State Scientific Center, Moscow (Russian Federation)

    2009-08-31

    Using elementary geometric tools, we apply essentially the same methods to derive expressions for the rotation angle of the swing plane of Foucault's pendulum and the rotation angle of the spin of a relativistic particle moving in a circular orbit (the Thomas precession effect). (methodological notes)

  13. “A Syriac Original for the Acts of Thomas? The Theory of the Syriac Priority Revisited, Evaluated and Rejected”

    NARCIS (Netherlands)

    Roig Lanzillotta, Lautaro; Ramelli, Ilaria; Perkins, Judith

    2015-01-01

    According to general consensus, the Acts of Thomas (ATh) were composed in third-century Eastern Syria. This theory not only relies on a rather shaky foundation but also places the ATh in a very discordant position within the context of the Apocryphal Acts of Apostles (AAA), all of them written in

  14. A Post-Colonial Dilemma Tale from the Harbour of St. Thomas in the US Virgin Islands

    DEFF Research Database (Denmark)

    Brichet, Nathalia Sofie

    2017-01-01

    The port of Charlotte Amalie on St Thomas has long been a vibrant centre for ship trafficking in the Caribbean, also during Danish colonial rule starting in 1672. In 1917, Denmark officially sold and left what came to be the US Virgin Islands. Not everybody left, though. The Danish owned business...

  15. Nutrients, sedimentation and total suspended solids in the St. Thomas East End Reserves in the Caribbean Sea from 2012-01-16 to 2013-11-25 (NCEI Accession 0139480)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains the results from monitoring in the St. Thomas East End Reserves (STEER) in St. Thomas, USVI, from January 2012 to November 2013. The...

  16. KANTIAN'S ETHICS AND THE POSSIBILITY OF ALTRUISM (THOMAS NAGEL A ÉTICA KANTIANA E A POSSIBILIDADE DO ALTRUÍSMO (THOMAS NAGEL

    Directory of Open Access Journals (Sweden)

    Jürgen Stolzenberg

    2010-12-01

    Full Text Available The present article discusses the relation of Th. Nagel’s ethics of altruism with kantian ethics. According to Nagel himself, his position resembles that of Kant in two respects: it defends the thesis of the autonomy of moral motivation, and it bases moral on a determinate self-conception of persons. However, differently from Kant, the principle of Nagel’s ethics is just the modest presupposition that persons essentially understand themselves as being one among a plurality of other persons. Starting from the nagelian argument in The Possibility of Altruism (1970, but contemplating also Nagel’s more recent position in The Last Word (1999, it is argued that in order to defend his conception of a rational ethics in a convincing way, Nagel has to approximate himself more to the kantian foundation of ethics than he wants to admit.O presente artigo discute a relação da ética do altruísmo, defendida por Thomas Nagel, com a ética kantiana. Segundo o próprio Nagel, sua posição é semelhante à de Kant sob dois aspectos: ela defende a tese da autonomia da motivação moral, e ela funda a moral numa determinada autoconcepção da pessoa. No entanto, diferentemente de Kant, o princípio da ética nageliana é apenas o pressuposto modesto de que uma pessoa essencialmente considera a si mesma como sendo uma numa pluralidade de pessoas. Partindo do argumento nageliano em The Possibility of Altruísmo (1970, mas contemplando também a posição mais recente de Nagel em The Last Word (1999, argumenta-se que Nagel só pode defender sua concepção de uma ética racional de modo convincente, se ele se aproximar mais da fundamentação kantiana da ética do que ele pretende.

  17. Doctrine of "Fair Price” by Thomas Aquinas: background, laws of development and specific interpretation

    Directory of Open Access Journals (Sweden)

    Nureev Rustem, M.

    2015-03-01

    Full Text Available The paper is dedicated premises of origin and patterns of development of the doctrine of “fair price” Aquinas. Showing contradictions exchange of agricultural products to urban goods and services, resulting in a developed feudalism. For agricultural products incoming to the city market, the situation was characterized as the free competition, while medieval guild tried to create a monopoly conditions for the production and sale of its products, which objectively leads to distortion of prices. Under these conditions, the development of the problem of "fair price" becomes extremely important. The paper shows how scholasticism using theological methodology, trying to solve this problem. Greed condemned, was considered evil and sin of avarice considered the source of all evils. This tradition goes back to the interpretation of the Gospel of Matthew John Chrysostom. Alexander Halensis one of the first attempted rehabilitation of commercial activities and even tried to criticize the position of the Pseudo-Chrysostom that the merchant is not pleasing to God. In the "sum of all theology" Alexander Halensis wrote that moral qualities profits depend on the circumstances of 6: 1. From the person selling (which allowed the laity, the monks are not allowed; 2. His intentions (satisfaction or desire for profit; 3. The method of sale (by fair means or fraud; 4. Time of trade (on weekdays or holidays, designed for prayer or service of God; 5. Selling place (in the market or in holy places; 6. Relationship to the buyers (which is expressed in the level - excessive or normal - the selling price. Analyzes the rationale arguments to grounding the doctrine of "fair price", show the evolution of the concept during XII - XIV centuries, as well as its relationship with the teachings of the scholastics on the percentage. The paper deals with various estimates of the concept of "fair value" of Thomas Aquinas, resulting in the history of economic thought. Critically

  18. Modeling semiflexible polymer networks

    OpenAIRE

    Broedersz, Chase P.; MacKintosh, Fred C.

    2014-01-01

    Here, we provide an overview of theoretical approaches to semiflexible polymers and their networks. Such semiflexible polymers have large bending rigidities that can compete with the entropic tendency of a chain to crumple up into a random coil. Many studies on semiflexible polymers and their assemblies have been motivated by their importance in biology. Indeed, crosslinked networks of semiflexible polymers form a major structural component of tissue and living cells. Reconstituted networks o...

  19. Tissue Classification

    Energy Technology Data Exchange (ETDEWEB)

    Robinson, David Gerald [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-01-01

    The project began as a e ort to support InLight and Lumidigm. With the sale of the companies to a non-New Mexico entity, the project then focused on supporting a new company Medici Technologies. The Small Business (SB) is attempting to quantify glucose in tissue using a series of short interferometer scans of the nger. Each scan is produced from a novel presentation of the nger to the device. The intent of the project is to identify and, if possible, implement improved methods for classi cation, feature selection, and training to improve the performance of predictive algorithms used for tissue classi cation.

  20. Application of the Thomas-Fermi statistical model to the thermodynamics of high density matter; Aplicacion del modelo estadistico de Thomas-Fermi a la termodinamica de medios ultradensos

    Energy Technology Data Exchange (ETDEWEB)

    Martin, R.

    1977-07-01

    The Thomas-Fermi statistical model, from the N-body point of view is used in order to have systematic corrections to the T-Fermis equation. Approximate calculus methods are found from analytic study of the T-Fermis equation for non zero temperature. T-Fermis equation is solved with the code GOLEM written in FORTRAN V (UNIVAC). It also provides the thermodynamical quantities and a new method to calculate several isothermal tables. (Author) 24 refs.

  1. Implementation of the Polarized HD target at the Thomas Jefferson National Accelerator Facility

    Energy Technology Data Exchange (ETDEWEB)

    Chaden Djalali; David Tedeschi

    2007-01-30

    The original goal of this proposal was to study frozen spin polarized targets (HD target and other technologies) and produce a conceptual design report for the implementation of such a target in the HALL B detector of the Thomas Jefferson National Accelerator Facility (JLab). During the first two years of the proposal, we came to the conclusion that the best suited target for JLab was a frozen spin target and helped with the design of such a target. We have not only achieved our original goal but have exceeded it by being involved in the actual building and testing of parts the target. The main reason for this success has been the hiring of a senior research associate, Dr. Oleksandr Dzyubak, who had more than 10 years of experience in the field of frozen spin polarized targets. The current grant has allowed the USC nuclear physics group to strengthen its role in the JLab collaboration and make important contribution to both the detector development and the scientific program.

  2. Self-Gravitating Bose-Einstein Condensates and the Thomas-Fermi Approximation

    Directory of Open Access Journals (Sweden)

    Viktor T. Toth

    2016-08-01

    Full Text Available Self-gravitating Bose-Einstein condensates (BEC have been proposed in various astrophysical contexts, including Bose-stars and BEC dark matter halos. These systems are described by a combination of the Gross-Pitaevskii and Poisson equations (the GPP system. In the analysis of these hypothetical objects, the Thomas-Fermi (TF approximation is widely used. This approximation is based on the assumption that in the presence of a large number of particles, the kinetic term in the Gross-Pitaevskii energy functional can be neglected, yet it is well known that this assumption is violated near the condensate surface. We also show that the total energy of the self-gravitating condensate in the TF-approximation is positive. The stability of a self-gravitating system is dependent on the total energy being negative. Therefore, the TF-approximation is ill suited to formulate initial conditions in numerical simulations. As an alternative, we offer an approximate solution of the full GPP system.

  3. On Speech, Print, and New Media: Thomas Nashe and Marshall McLuhan

    Directory of Open Access Journals (Sweden)

    Neil Rhodes

    2009-10-01

    Full Text Available Marshall McLuhan, pioneer of modern media studies, wrote his Ph.D. thesis on the Elizabethan writer Thomas Nashe and the history of the classical trivium. This essay shows how McLuhan’s early exposure to Nashe influenced his later work on speech, print, and modern media. It argues that Nashe’s use of print to re-create oral conditions and his invention of personae drawn from fairground and marketplace helped shape McLuhan’s response to media and popular culture. Rhodes goes on to argue that it was Nashe’s attack on Ramus, to which McLuhan gave particular emphasis, that was the source of the idea that print promotes linear thinking and closure at the expense of the very different qualities associated with oral culture. He ends by countering some of the charges made against McLuhan that he sentimentalizes the oral by using it to represent an ideal of human wholeness.

  4. Which Way Is Up? Thomas S. Kuhn's Analogy to Conceptual Development in Childhood

    Science.gov (United States)

    Levine, Alexander T.

    In the Preface to his Structure Of Scientific Revolutions, Thomas S. Kuhn let it be known that his view of scientific development was indebted to the work of pioneering developmental psychologist Jean Piaget. Piaget's model of conceptual development in childhood, on which the child passes through several discontinuous stages, served as the template for Kuhn's reading of the history of a scientific discipline, on which mutually incommensurable periods of normal science are separated by scientific revolutions. The analogy to conceptual change in childhood pervades Kuhn's corpus, serving as the central motif in his well-known essays, A Function for Thought Experiments and Second Thoughts on Paradigms. But it is deeply problematic. For as a careful student of Piaget might note, Piaget, and the developmental psychologists he inspired, relied on the same analogy, but with the order of epistemic dependencies reversed. One begins to worry that Kuhn's use of the analogy, and its subsequent re-use by developmental psychologists, sneaks a vicious circularity into our understanding of important processes. This circularity is grounds for some concern on the part of science educators accustomed to employing such Kuhnian notions as incommensurability and paradigm.

  5. Thomas Alva Edison—battery and device innovation in response to application's needs

    Science.gov (United States)

    Salkind, Alvin J.; Israel, Paul

    Thomas Alva Edison, the most prolific inventor in North America, with over 1000 patents, was the descendant of early settlers from the Netherlands to the Hudson Valley region of New York/New Jersey. However, his genealogical trail encompasses many cities, provinces, states, and countries, including Holland, France, Scotland, New Amsterdam, New York, New Jersey, Nova Scotia, Ontario, Ohio, and Michigan. He was motivated to develop and invent in response to perceived needs of commercial devices and was the creator of the concept of an industrial research laboratory. His activities covered a wide-range of chemical, electrical, medical, metallurgical, entertainment, and communication devices and led to the creation of major worldwide industries. However, his expressed underlying concern was the "service it might give others". This presentation reviews commercial developments in comparison with the technologies and motivations of the time and is illustrated by material from the Rutgers University 'Edison Papers Project', Edison's personal notes found in the Edison Battery Factory and preserved by Professor Salkind, and records of The Electrochemical Society.

  6. Social practices transformation: Peter Berger’s and Thomas Luckmann’s theory in crisis society

    Directory of Open Access Journals (Sweden)

    E D Osipova

    2015-12-01

    Full Text Available The article is devoted to Peter Berger’s and Thomas Luckmann’s theory of the construction of reality in the context of social practices transformation in the risk society. According to this theory, daily routine appears to be the basis of social reality that is interpreted as the result of the interaction processes. The article considers the fundamental procedures of the social reality construction - institutionalization and legitimization; such an analysis proves the famous sociologists idea that the daily routine is the foundation of social world. However, while analyzing daily routine practices we can see that the habitual behavior patterns are changing and new types of action are developing in the situation of the unstable and unpredictable crisis society. In the contemporary world, the habitual rational logic that we traditionally followed in everyday life to organize our behavior does not fulfill its functions. As a result, a special type of social consciences named catastrophic thinking is developing. Referring to the data of sociological studies the article considers the most striking examples of the social practices transformation and the new type of rational logic development, such as the changing attitudes to the health and the reviving interest to making a will in the contemporary world.

  7. [Universal elixir of Thomas-Nicolas Larcheret (1819) and his elixirian and normal doctrine].

    Science.gov (United States)

    Bonnemain, Bruno

    2014-06-01

    Thomas-Nicolas Larcheret, teacher in singing, declamation, guitar or lyre and violin, author of music and books, but also inventor of the universal elixir by his name, is a good example of quack of the 19th century. His book Larcheregium ou Dictionnaires spéciaux de mon élixir, ainsi que toute ma doctrine et de mes adhérens (Larcheregium or special Dictionaries of my elixir, as well as all my doctrine and my adherents), published in 1819, deserves a deep study to show the most frequently used arguments by the ones who emphasize the value of their secret remedy. The opportunities are there to present themselves as victims of medical authorities, experts and authorities as a whole, that do not recognize the value of their product. The only acceptable judge for them is the experience reported by the patients who are able to demonstrate the efficacy of the product since they do buy it (probably at a very high price). From this viewpoint, the book of Larcheret is a good example of turning the authorities down and of diatribe against physicians and pharmacists. It is also the demonstration that, even with the Empire's new regulations against secret remedies and quacks, they will still persist for a large part of the 19th century in France.

  8. Book Review - CAPITAL IN THE 21ST CENTURY, BY THOMAS PIKETTY

    Directory of Open Access Journals (Sweden)

    Elena Gurgu

    2016-07-01

    Full Text Available Only few books of economy in the recent past years have had a similar effect on public opinion as the work of Professor Thomas Piketty from Paris School of Economics, in which he attempts to explain the dynamics of the last two centuries income inequality in developed countries. Shortly after the release of the English version, appeared excellent reviews from some major economists like Robert Solow, Paul Krugman, Robert Shiller, all three Nobel Prize winners, as we all know.             "It is the most important book of the century" concluded Esquire magazine, and Paul Krugman, Nobel Prize winner for Economics, described it as "a volume really superb" and "an extraordinary work [...] certainly the most economic important book of the year if not the decade."             In turn, Martin Wolf, one of the most influential writers on economic issues worldwide, says that the work of Piketty is "extremely important" and Branko Milanovic, a former World Bank economist, said it is "one of the primary work of economic thought ".

  9. Employment contracts and marriage settlements in Thomas Mann's The Tales of Jacob

    Directory of Open Access Journals (Sweden)

    Elisabetta Abignente

    2012-04-01

    Full Text Available Together with the representation of the justice court, the pact scene is one of the narrative elements that are more interesting for ‘Law in Literature’ studies. The pact, in his double meaning of ‘horizontal’ agreement between two people and ‘vertical’ alliance between a man and a supreme divine or diabolical being, is particularly present in the narrative work of Thomas Mann. The tale of the seven years biblical waiting of Jacob and Rachel that is told in the first volume of Joseph tetralogy, Die Geschichten Jaakobs, gives one of the most significant examples in this sense. This is the series of three contracts signed by Jacob and Laban, Rachel’s father, which are anomalous because they are employment contracts and marriage settlements at the same time. By a careful rereading of this scene, the paper aims to investigate which is the main narrative function of the scene of the pact in the fictional context. Totally absent from the biblical source, the scene of the contract becomes the instrument, inside the novel, of that process of ‘dilatation’ and ‘humanization’ of the myth on which Mann’s monumental rewriting is found.

  10. The Secret Life of Archives: Sally Siddons, Sir Thomas Lawrence, and The Material of Memory

    Directory of Open Access Journals (Sweden)

    Laura Engel

    2014-03-01

    Full Text Available This essay is in two parts, in the first I attempt to map out strategies for considering archival materials through the lens of performance, and in the second I enact or perform some of those strategies through a close reading of a letter from Sally Siddons, daughter of the famous actress Sarah Siddons, to the renown portrait painter and rakish bad boy, Sir Thomas Lawrence. I present a methodology that considers archival researchers as tourists who approach archival objects and images as material for curating a virtual exhibition. I argue that this strategy allows us to recognize and attempt to envision the interdisciplinary relationship amongst archival materials in order to imagine them in spatial, theatrical, and visual proximity to one another. In this way as researchers we are performing a kind of re-enactment, an animation, of the secret life of archives, which attempts to account the embodied traces of the past by providing an accessible thought provoking map for audiences.

  11. The Roman Catholic Tradition in Conversation with Thomas Berry’s Fourfold Wisdom

    Directory of Open Access Journals (Sweden)

    Simon Appolloni

    2015-07-01

    Full Text Available Taking the threatening anthropogenic global environmental destruction—the anthropocene—as a starting point, this paper examines the Catholic tradition, which has remained relatively indifferent to this looming crisis, asking what might help it to change its focus from a decided human ecology to one that counts the human as an integral part of the larger natural ecology. Thomas Berry, whose teachings underlie this work, suggests that since the tradition has grown out of a cosmological perspective that places the human being at the center of ethical deliberations and separate from the natural world, it needs to rely on other Earth-centered and ecological expressions to help Catholics to discover more harmonious avenues of being on Earth, which he describes as a fourfold wisdom—the wisdoms of indigenous peoples, classical traditions, women, and science. Through a critical weaving of these wisdoms into a conversation with the Catholic tradition, this article examines the efficacy of the fourfold wisdom to transform the tradition into a more Earth-honoring expression. While this work concludes that the fourfold wisdom is effecting change where engaged, it also reflects on the challenges and opportunities this engagement faces in light of current realities within the Catholic tradition.

  12. Écrire, habiter, penser autour de l’oeuvre de Thomas Bernhard

    Directory of Open Access Journals (Sweden)

    Frédéric Marteau

    2008-04-01

    Full Text Available Les romans et récits de Thomas Bernhard tournent souvent autour d’un lieu spécifique ; plus généralement, la thématique de l’habiter hante son oeuvre; car penser, c’est-à-dire aussi écrire, nécessite un lieu de recueillement. Mais ce lieu de pensée s’avère être un lieu d’enfermement, qui mène à la destruction et à l’anéantissement. Digne héritier de Kafka, Bernhard entremêle différents types de constructions : des constructions d’habitats, des constructions de pensées et des constructions verbales. Tentative paradoxale de construction/destruction de et dans la langue, l’oeuvre de Bernhard éclaire les relations entre la maison et le livre, l’écrire et l’habiter, l’extinction des lieux et le surgissement paradoxal de l’oeuvre.

  13. The Development of Genetics in the Light of Thomas Kuhn's Theory of Scientific Revolutions.

    Science.gov (United States)

    Portin, Petter

    2015-01-01

    The concept of a paradigm is in the key position in Thomas Kuhn's theory of scientific revolutions. A paradigm is the framework within which the results, concepts, hypotheses and theories of scientific research work are understood. According to Kuhn, a paradigm guides the working and efforts of scientists during the time period which he calls the period of normal science. Before long, however, normal science leads to unexplained matters, a situation that then leads the development of the scientific discipline in question to a paradigm shift--a scientific revolution. When a new theory is born, it has either gradually emerged as an extension of the past theory, or the old theory has become a borderline case in the new theory. In the former case, one can speak of a paradigm extension. According to the present author, the development of modern genetics has, until very recent years, been guided by a single paradigm, the Mendelian paradigm which Gregor Mendel launched 150 years ago, and under the guidance of this paradigm the development of genetics has proceeded in a normal fashion in the spirit of logical positivism. Modern discoveries in genetics have, however, created a situation which seems to be leading toward a paradigm shift. The most significant of these discoveries are the findings of adaptive mutations, the phenomenon of transgenerational epigenetic inheritance, and, above all, the present deeply critical state of the concept of the gene.

  14. The mine and the furnace: Francis Bacon, Thomas Russell, and early Stuart mining culture.

    Science.gov (United States)

    Pastorino, Cesare

    2009-01-01

    Notwithstanding Francis Bacon's praise for the philosophical role of the mechanical arts, historians have often downplayed Bacon's connections with actual artisans and entrepreneurs. Addressing the specific context of mining culture, this study proposes a rather different picture. The analysis of a famous mining metaphor in The Advancement of Learning shows us how Bacon's project of reform of knowledge could find an apt correspondence in civic and entrepreneurial values of his time. Also, Bacon had interesting and so far unexplored links with the early modern English mining enterprises, like the Company of Mineral and Battery Works, ofwhich he was a shareholder. Moreover, Bacon's notes in a private notebook, Commentarius Solutus, and records of patents of invention, allow us to start grasping Bacon's connections with the metallurgist and entrepreneur Thomas Russell. Lastly, this paper argues that, to fully understand Bacon's links with the world of Stuart technicians and entrepreneurs, it is necessary to consider a different and insufficiently studied aspect of Bacon's interests, namely his work as patents referee while a Commissioner of Suits.

  15. Tunicates: exploring the sea shores and roaming the open ocean. A tribute to Thomas Huxley

    Science.gov (United States)

    Lemaire, Patrick; Piette, Jacques

    2015-01-01

    This review is a tribute to the remarkable contributions of Thomas Huxley to the biology of tunicates, the likely sister group of vertebrates. In 1851, the great biologist and philosopher published two landmark papers on pelagic tunicates in the Philosophical Transactions of the Royal Society. They were dedicated to the description of the adult anatomy and life cycle of thaliaceans and appendicularians, the pelagic relatives of ascidians. In the first part of this review, we discuss the novel anatomical observations and evolutionary hypotheses made by Huxley, which would have a lasting influence on tunicate biology. We also briefly comment on the more philosophical reflections of Huxley on individuality. In the second part, we stress the originality and relevance of past and future studies of tunicates in the resolution of major biological issues. In particular, we focus on the complex relationship between genotype and phenotype and the phenomenon of developmental system drift. We propose that more than 150 years after Huxley's papers, tunicate embryos are still worth studying in their own right, independently of their evolutionary proximity to vertebrates, as they provide original and crucial insights into the process of animal evolution. Tunicates are still at the forefront of biological research. PMID:26085517

  16. Friendship in the shadow of death. Reflections on the prose of Thomas Bernhard

    Directory of Open Access Journals (Sweden)

    Agata Barełkowska

    2010-01-01

    Full Text Available The bond of friendship becomes in a number of novels by Thomas Bernhard increasingly important and one of the planes or realms of existence, more often than not inescapably related to some kind of an entanglement, and almost the most precious relation in one’s life — at least one of the most important frames of reference. The chronological order of the texts in which friendship plays a significant role is as follows: Korrektur (Correction, 1975, Wittgenstein’s Nephew (1982, The Loser (1983, Holzfaellen (Cutting Timber, 1984, Extinction (1986. The novelistic worlds created in Extinction and Holzfaellen could not have existed without friendship. However, in Bernhard’s discussion on friendship, the most interesting moments happen when it becomes not only a sanctuary or grievance, but rather when provides inspiration for new escapades of the mind and is an equivocal force (however miraculous and containing traces of genius and madness portraying vague relationships that sometimes almost cross the border of friendship. Additionally, particular strains carrying the stigma of absence of a friend, so distinctive for the whole of the literary output of Bernhard, are notable — the author usually writes about friendship from within the perspective of death or, as in the case of Wittgenstein’s Nephew, from the perspective of dying.

  17. Relativistic extended Thomas-Fermi calculations of finite nuclei with realistic nucleon-nucleon interactions

    Energy Technology Data Exchange (ETDEWEB)

    Centelles, M.; Vinas, X.; Barranco, M. (Departament d' Estructura i Constituents de la Materia, Facultat de Fisica, Universitat de Barcelona, Diagonal 647, E-08028 Barcelona (Spain)); Ohtsuka, N.; Faessler, A.; Khoa, D.T.; Muether, H. (Institut fuer Theoretische Physik, Universitaet Tuebingen, Auf der Morgenstelle 14, D-7400 Tuebingen (Germany))

    1993-03-01

    A relativistic energy density functional is constructed to investigate the Dirac effects on different properties of the structure and scattering of finite nuclei. The kinetic energy density has been derived within a relativistic extended Thomas-Fermi model and includes gradient corrections to second order in [h bar]. The effective mass and the volume term of the potential energy density have been obtained from a local density approximation to Dirac-Brueckner calculations of nuclear matter carried out with a realistic nucleon-nucleon interaction. This volume term is supplemented by the Coulomb energy and by conventional phenomenological surface and symmetry terms, and the few free parameters of the functional are suitably adjusted. Attention is then focused on the calculation of fission barriers of rotating nuclei and of the complex optical potential for heavy ion collisions at intermediate energies. It turns out that the effects of the density-dependent Dirac spinor which have been incorporated in this approach allow for a reasonable description of the investigated properties.

  18. [Painting realism and medicine: the two surgical clinics of Thomas Eakins].

    Science.gov (United States)

    Cabello, Felipe

    2015-06-01

    Realism is a painting style that began with Millet and Courbet in politically convulsed France in the middle of the nineteenth century. In the second half of that century, the pragmatic and democratic tradition of the United States fostered the careers of many realist painters, including that of Thomas Eakins. Eakins, trained in France, developed his career completely associated with Philadelphia at a time when this city was in the vanguard of American emerging industry, culture and medicine. Eakins "The clinic of Dr. Gross" and the "The clinic of Dr. Agnew" are icons of these developments and symbolize a perfect union of art and medicine. Both paintings permit the viewer to appreciate the artist's mastery, originality and Americanism while simultaneously tracking the progress of surgery as evidenced by the introduction of asepsis, anesthesia and nursing. Eakins mastery is revealed by its use of some European Old Masters approaches to portray medical professionals undertaking their daily duties in their work environments with critical and unadorned vision. This combination of vision and skills led Eakins to create a highly original yet analytical art. Unfortunately, his representations were far ahead of his time and resulted in under appreciation of his paintings and a censorious reaction to their content. His contemporaries rejection of Eakins work negatively affected his career as a painter, as a teacher and even his private life. This judgment was overturned in subsequent years and by the twentieth century Eakins was recognized as an American master without parallel.

  19. Logic of Leadership Research: A Reflective Review of Geeks & Geezers by Bennis and Thomas

    Directory of Open Access Journals (Sweden)

    D. P. Dash

    2005-01-01

    Full Text Available [First two paragraphs] Leadership has turned out to be one of those topics, which persistently slip out of scientific hands. The field of leadership research should be of interest to researchers in various other disciplines, because it serves as a source of examples of many common difficulties faced by researchers in general. These relate to difficulties in defining a research task, specifying quality criteria, choosing methods, ensuring that the research programme remains progressive (the criterion is from Lakatos, see Science and Pseudoscience, 2004; Worrall & Currie, 1978, etc. The book by well-known leadership researchers, Bennis and Thomas, gives us an occasion to critically appreciate the practice of leadership research so far and assess the book’s potential contribution. This will be done by first outlining the developments in leadership research since the 1930s. It will be shown that although the book’s focus is interestingly different, it does not go so far as to reframe the logic of research in the field.

  20. Venous thromboembolism capture on electronic systems in obstetrics patients at St Thomas' Hospital.

    Science.gov (United States)

    Ahmad, Aminah Noor; Byrne, Megan Leyla; Imambaccus, Nazia; Hubert, Dawid; Gateley, Anna; Abdullahi Idle, Salwa; Lloyd, Jilly

    2016-01-01

    Venous thromboembolism (VTE) is one of the leading causes of maternal mortality in the UK. Therefore, timely VTE risk assessment is essential in all obstetrics patients. The Commissioning for Quality and Innovation (CQUIN) payment framework set a target for trusts to complete a VTE risk assessment within 24 hours of admission for 95% of patients. A combination of factors, including lack of integration between multiple IT systems, means that this CQUIN target is currently not being met for obstetric patients in the Hospital Birth Centre at Guys and St Thomas' NHS Trust. This project aims to increase staff awareness of this issue and educate them regarding the correct procedure for VTE assessment. Trialled methods included reminders at staff handovers, use of magnets on the patient whiteboard, posters and stickers displayed around the unit and a loyalty card scheme as incentive to complete assessments. Initial average completion rate was 20.7%, which increased to 67.5% after the first plan, do, study, act (PDSA) cycle with a slight drop to 65.7% after the second cycle. Completion rates increased to 92.3% on the last day of the third PDSA cycle. Although we did not reach the 95% target, we have raised awareness of the importance of recording VTE assessment on electronic systems, and hope we have created sustainable change.

  1. Modified Thomas splint-cast combination for the management of limb fractures in small equids.

    Science.gov (United States)

    Ladefoged, Søren; Grulke, Sigrid; Busoni, Valeria; Serteyn, Didier; Salciccia, Alexandra; Verwilghen, Denis

    2017-04-01

    To describe the management and outcome of limb fractures in small domestic equids treated with a modified Thomas splint-cast combination (MTSCC). Retrospective case series. Client owned horses and donkeys. Medical records, including radiographs, were reviewed for details of animals diagnosed with a limb fracture and treated by external coaptation using a MTSCC (2001-2012). Follow-up >6 months after discharge was obtained via telephone consultation with owners or veterinarians. Nine horses and 4 donkeys were identified with fractures of the tibial diaphysis (n = 4), ulna (n = 3), distal metatarsus (n = 2), proximal metacarpus (n = 1), radial diaphysis (n = 1), calcaneus (n = 1), and distal femoral physis (n = 1). Follow-up was available for 12 equids, of which 8 (67%) recovered from the fracture and became pasture sound. Six equids developed obvious external deformation of the affected limb. Selected small equids with long bone fractures, and without athletic expectations, can be managed with external coaptation using an MTSCC. The owner should be informed that the treatment is considered a salvage procedure. © 2017 The American College of Veterinary Surgeons.

  2. Tomás de Aquino: filosofia e pedagogia = Thomas Aquinas:philosophy and pedagogy

    Directory of Open Access Journals (Sweden)

    Luiz Jean Lauand

    2012-01-01

    Full Text Available O artigo discute a conexão ente filosofia e educação em Tomás de Aquino. Em sua antropologia filosófica, destacam-se três aspectos de grande atualidade para a educação hoje: a valorização da matéria no ser do homem, a primazia da virtude da prudência entre as virtudes cardeais e a philosophia negativa (e theologia negativa. A intrínseca união entre espírito e matéria, anima forma corporis tem também importantes consequências pedagógicas, tanto para a educação intelectual quanto para a moral. E está na base de seu De prudentia, que pressupõe também sua perspectiva negativa.This article discusses the connection between philosophy and education in Thomas Aquinas. In his Philosophical Anthropology there are three aspects very important for education today: the affirmation of matter as an essential in human being, the primacy of prudentia over the cardinal virtues and his philosophia negativa (and theologia negativa. The intrinsec union spirit-matter, anima forma corporis has important pedagogical consequences, both in intellectual and in moral education. And it is the basis for his Treatise On Prudence, which presupposes his negative perspective too.

  3. A Strange Case of Hero-Worship: John Mitchel and Thomas Carlyle

    Directory of Open Access Journals (Sweden)

    Michael Huggins

    2013-03-01

    Full Text Available The Scottish essayist Thomas Carlyle might be considered a surprising influence on the Young Ireland movement of the 1840s and its most militant leader, John Mitchel. Carlyle has become notorious for his anti-Irish sentiments, expressed most forcefully in his Reminiscences of my Irish journey in 1849. Yet his critique of the Benthamite and liberal Zeitgeist was a significant influence on Mitchel. This article examines what it was in Carlyle’s thought that appealed to Mitchel. Carlyle’s antagonism to liberal conceptions of progress informed Mitchel’s intellectual development and prompted specific political perspectives that can in some measure be viewed as a Carlylean response to Ireland’s crisis in the 1840s. Mitchel made many of the same historic and philosophical assumptions as Carlyle, legitimising the present struggle for Irish nationality via a critique of contemporary laissez-faire doctrine. Thus, Swift’s saeva indignatio was inflected in Mitchel by his encounter with Carlyle’s work, shaping Mitchel’s anger in terms of the spiritual-material polarity at the heart of Carlyle’s Signs of the Times (1829. This ‘sacred wrath’ helps explain why Mitchel is often seen as someone who hated England more than he loved Ireland.

  4. Seafloor elevation change in Maui, St. Croix, St. Thomas, and the Florida Keys

    Science.gov (United States)

    Yates, Kimberly K.; Zawada, David G.; Smiley, Nathan A.; Range, Ginger; Resnick, Jessica

    2017-01-01

    The U.S. Geological Survey (USGS) St. Petersburg Coastal and Marine Science Center conducted research to quantify the combined effect of all constructive and destructive processes on modern coral reef ecosystems by measuring regional-scale changes in seafloor elevation. USGS staff assessed five coral reef ecosystems in the Atlantic Ocean (Upper and Lower Florida Keys), Caribbean Sea (U.S. Virgin Islands: St. Thomas and Buck Island, St. Croix), and Pacific Ocean (Maui, Hawaii), including both coral-dominated and adjacent, non-coral dominated habitats. Scientists used historical bathymetric data from the 1930s to 1980s and contemporary light detection and ranging (lidar) digital elevation models (DEMs) from the late 1990s to 2000s to calculate changes in seafloor elevation for each study site over time periods reflecting low to high anthropogenic impacts. This data release contains the location, elevation, and elevation change data used in this study. Using these changes in elevation, further analysis was done to calculate corresponding changes in seafloor volume for all study areas and habitat types within each site.For further information regarding data analysis methods refer to DOI: 10.5194/bg-14-1739-2017

  5. The 24th annual meeting of the European Tissue Repair Society (ETRS) in Edinburgh, Scotland.

    Science.gov (United States)

    Shaw, Tanya J; Lippens, Evi

    2014-01-01

    From the 10th to 12th of September 2014, in the midst of the Scottish Independence debate, the European Tissue Repair Society descended on Edinburgh for their 24th Annual Meeting. In the beautiful and historic setting of the Royal College of Surgeons of Scotland, Professors David Thomas (Chair), Phil Stephens, Chris Lloyd, and their teams from Cardiff hosted an educational and inspiring program. © 2015 by the Wound Healing Society.

  6. Hans Thomae: The Individual and His/Her World in the Flux of Time: History and Biography in Psychological Research

    Directory of Open Access Journals (Sweden)

    Jürgen Straub

    2004-09-01

    Full Text Available The interview explores the important academic experiences with mentors and intellectual impulses which have supported and guided the psychological thinking of Hans THOMAE, especially in his approach to "biographical method." Questions about motivation in human activity, consciousness and life history are impulses that—mediated and guided by NIETZSCHE, HERDER, MORITZ, SPRANGER, ROTHACKER, LERSCH and KLAGES among others—finally led THOMAE to the development and shaping of a "biographical method" in psychology; a method which propagates the inclusion of the individual's life-story, the openness and clarity of the survey, as well as a synthesis of nomological and ideographical approaches to qualitative and quantitative research. URN: urn:nbn:de:0114-fqs040368

  7. Addressing the underlying issues of Romantic elegy — Thomas Gray’s Elegy written in a country churchyard

    Directory of Open Access Journals (Sweden)

    Piotr Śniedziewski

    2011-01-01

    Full Text Available From the beginning of his literary career, Thomas Gray consciously and consistently created a lyric with a poetic effect quite of its own in which a personal element (death of a friend kept on vanishing, toposes and literary allusions overlapped (e.g. images of melancholy inspired by works of John Milton and Thomas Warton and in which bitter philosophical reflection on life and death mounted in time. It is this reflection that predestined the groundbreaking character of Elegy written in a country churchyard and determined its popularity in English literature and beyond. The interpretation of space, the reflection on the subjectivity and the role of the epitaph (constituting at the same time a structural part of Elegy..., as well as the funeral genre that is thematically related to the Gray’s poem have made it possible to show the poem written in mid-eighteenth century as a substantial reference point for Romantic authors transforming the genre.

  8. The Legacy of Thomas Hodgkin Is Still Relevant 150 Years After His Death. Nothing of Humanity Was Foreign to Him

    Directory of Open Access Journals (Sweden)

    Eldad J. Dann

    2017-01-01

    Full Text Available Current leading figures in medical science usually focus on very specific topics and use cutting-edge technologies to broaden our knowledge in the field. The working environment of the nineteenth century was very different. Medical giants of that time such as Rudolph Virchow and Thomas Hodgkin had a wide-ranging scope of research and humanitarian interests and made enormous contributions to a variety of core areas of medicine and the well-being of mankind. The year 2016 marked the 150th anniversary of the death of Dr Thomas Hodgkin. Even a brief review of his life and work proves the current relevance of the outstanding deeds of this exceptional physician, medical educator, and defender of human rights for the poor and underprivileged; his vision was far ahead of his time.

  9. Sub-saturation matter in compact stars: Nuclear modelling in the framework of the extended Thomas-Fermi theory

    Energy Technology Data Exchange (ETDEWEB)

    Aymard, François; Gulminelli, Francesca [CNRS and ENSICAEN, UMR6534, LPC, 14050 Caen cédex (France); Margueron, Jérôme [Institut de Physique Nucléaire de Lyon, Université Claude Bernard Lyon 1, IN2P3-CNRS, F-69622 Villeurbanne Cedex (France)

    2015-02-24

    A recently introduced analytical model for the nuclear density profile [1] is implemented in the Extended Thomas-Fermi (ETF) energy density functional. This allows to (i) shed a new light on the issue of the sign of surface symmetry energy in nuclear mass formulas, as well as to (ii) show the importance of the in-medium corrections to the nuclear cluster energies in thermodynamic conditions relevant for the description of core-collapse supernovae and (proto)-neutron star crust.

  10. An Analysis on the Images of the Devils in the Works of Geothe, Bulgakov and Thomas Mann

    Directory of Open Access Journals (Sweden)

    Jie CHANG

    2013-10-01

    Full Text Available Starting from the analysis on the devils in the Bible stories, the writer of this article makes an analysis on Mephistopheles in Faust by JohannEolfgang von Goethe (1749-1832 Woland in The Master and Margarita by Mikhaíl Afanasyevich Bulgakov (1891-1940, and a Mephistopheles figure in Doctor Faustus by Thomas Mann (1875-1955. The origin, characteristics and changes of the images of these devils shall be discussed in this article.

  11. Towards a Wise Despotism: Traces of Thomas Carlyle in the BBC North and South (2004)

    OpenAIRE

    Mark Wallace

    2012-01-01

    Thomas Carlyle was among the most influential writers in the English language during the 19th century, but is now ostensibly absent from cultural memory. Nevertheless, his ideas may be seen to live on indirectly in the works of the writers he influenced, one of whom is Elizabeth Gaskell. The 2004 adaptation of Gaskell’s North and South provides an instance of a modern approach to Carlylean ideas embodied in the source text. The adaptation finds itself in dialogue with Carlylean notions ...

  12. NOAA TIFF Image- 0.5 meter Backscatter Mosaic of Mid Shelf Reef (St. Thomas), US Virgin Islands, Project NF-05-05, 2005, UTM 20 NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a 0.5 meter resolution backscatter mosaic of the Mid Shelf Reef south of St. Thomas, US Virgin IslandsNOAA's NOS/NCCOS/CCMA Biogeography Team,...

  13. Thomas Armstrong (2012: El poder de la neurodiversidad. Las extraordinarias capacidades que se ocultan tras el autismo, la hiperactividad, la dislexia y otras diferencias cerebrales. Barcelona: Espasa Libros.

    Directory of Open Access Journals (Sweden)

    Ángela María Lopera Murcia

    2017-06-01

    Full Text Available Reseña de la obra 'El poder de la neurodiversidad. Las extraordinarias capacidades que se ocultan tras el autismo, la hiperactividad, la dislexia y otras diferencias cerebrales' (2012 de Thomas Armstrong.

  14. Thomas Armstrong (2012): El poder de la neurodiversidad. Las extraordinarias capacidades que se ocultan tras el autismo, la hiperactividad, la dislexia y otras diferencias cerebrales. Barcelona: Espasa Libros.

    OpenAIRE

    Ángela María Lopera Murcia

    2017-01-01

    Reseña de la obra 'El poder de la neurodiversidad. Las extraordinarias capacidades que se ocultan tras el autismo, la hiperactividad, la dislexia y otras diferencias cerebrales' (2012) de Thomas Armstrong.

  15. Thomas Jefferson, I dilemmi della democrazia americana, translated and edited by Alberto Giordano, with a preface by Dino Cofrancesco (Novi Ligure: Città del Silenzio, 2007

    Directory of Open Access Journals (Sweden)

    Pierluigi Chiassoni

    2010-03-01

    Full Text Available A review of Thomas Jefferson, I dilemmi della democrazia americana, translated and edited by Alberto Giordano, with a preface by Dino Cofrancesco (Novi Ligure: Città del Silenzio, 2007

  16. NOAA TIFF Image- 0.5 meter Backscatter Mosaic of Grammanik Bank - East (St. Thomas), US Virgin Islands, Project NF-05-05, 2005, UTM 20 NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a 0.5 meter resolution backscatter mosaic of Grammanik Bank, south of St. Thomas, US Virgin Islands.NOAA's NOS/NCCOS/CCMA Biogeography Team, in...

  17. Chemical data collected from THOMAS G. THOMPSON using CTD and bottle casts in Arabian Sea from 08 January 1995 to 26 November 1995 (NODC Accession 9800161)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Chemical data were collected using CTD and bottle casts in the Arabian Sea from THOMAS G. THOMPSON. Data were collected from 08 January 1995 to 26 November 1995 by...

  18. Interbasin groundwater flow in south central Nevada: A further comment on the discussion between Davisson et. al.. [1999a, 1999b] and Thomas [1999

    National Research Council Canada - National Science Library

    Winograd, Isaac J

    2001-01-01

    In their response to the comments by Thomas [1999], Davisson et al. [1999a] dismiss a large set of potentiometric measurements pertinent to an understanding of the hydrogeology of Yucca and Frenchman Flats in southcentral Nevada...

  19. WATER TEMPERATURE and Other Data from THOMAS G. THOMPSON From TOGA Area - Pacific (30 N to 30 S) from 19920130 to 19921021 (NODC Accession 9700049)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hydrochemical, hydrophysical, and other data were collected from the THOMAS G. THOMPSON from January 30, 1992 to October 21, 1992. Data were submitted by Dr. Robert...

  20. ZOOPLANKTON SPECIES IDENTITIES and Other Data from THOMAS G. THOMPSON From TOGA Area - Pacific (30 N to 30 S) from 19920203 to 19921021 (NODC Accession 9700062)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Abundance, biovolume, and biomass of (Cyanobacteria, phototrophic, heterotrophic eucaryotic pico and nanoplanktons) were collected from the THOMAS G. THOMPSON from...

  1. GeoTIFF of 3x3 m Bathymetry for St. Thomas & St. John, 2011, UTM 20N NAD83 (NCEI Accession 0131858)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a LiDAR (Light Detection & Ranging) 3x3 meter resolution bathymetric surface for an area of shallow seabed surrounding St. Thomas and St....

  2. Book Review: Jandl, Thomas, Vietnam in the Global Economy – The Dy-namics of Integration, Decentralization and Contested Politics

    Directory of Open Access Journals (Sweden)

    Adam Fforde

    2014-01-01

    Full Text Available Book Review of the Monograph: Thomas Jandl (2013, Vietnam in the Global Economy – The Dynamics of Integration, Decentralization and Contested Politics. Plymouth: Lexington Books, ISBN 978-0-7391-7786-0, 312 pages

  3. ZOOPLANKTON SPECIES IDENTITIES and Other Data from THOMAS G. THOMPSON From TOGA Area - Pacific (30 N to 30 S) from 19920203 to 19921021 (NODC Accession 9700058)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Depth, abundance and biomass of (Radiolarians, Formainiferans, Acantharians) were collected from the THOMAS G. THOMPSON from February 3, 1992 to October 21, 1992....

  4. Profile data collected from CTD casts aboard the Thomas G. Thompson in the Northeast Pacific from 20060803 to 20060816 (NODC Accession 0043455)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These profile data were collected from CDT casts aboard the Thomas G. Thompson in the Northeast Pacific as part of an effort to understand the cause of the...

  5. Rezension: Die Tode in Venedig/Morte a Venezia. Thomas Mann/Luchino Visconti: un confronto von Francesco Bono, Luigi Cimmino und Giorgio Pangaro (Hg.

    Directory of Open Access Journals (Sweden)

    Valerio Furneri

    2014-12-01

    Full Text Available Valerio Furneri rezensiert einen schönen, soeben in Italien erschienenen Band zum 'Tod in Venedig' bei Thomas Mann und Luchino Visconti, der erneut das interessante Forschungsfeld zwischen Kino und Literatur zum Gegenstand hat ...

  6. Multiscale mechanical modeling of soft biological tissues

    Science.gov (United States)

    Stylianopoulos, Triantafyllos

    2008-10-01

    Soft biological tissues include both native and artificial tissues. In the human body, tissues like the articular cartilage, arterial wall, and heart valve leaflets are examples of structures composed of an underlying network of collagen fibers, cells, proteins and molecules. Artificial tissues are less complex than native tissues and mainly consist of a fiber polymer network with the intent of replacing lost or damaged tissue. Understanding of the mechanical function of these materials is essential for many clinical treatments (e.g. arterial clamping, angioplasty), diseases (e.g. arteriosclerosis) and tissue engineering applications (e.g. engineered blood vessels or heart valves). This thesis presents the derivation and application of a multiscale methodology to describe the macroscopic mechanical function of soft biological tissues incorporating directly their structural architecture. The model, which is based on volume averaging theory, accounts for structural parameters such as the network volume fraction and orientation, the realignment of the fibers in response to strain, the interactions among the fibers and the interactions between the fibers and the interstitial fluid in order to predict the overall tissue behavior. Therefore, instead of using a constitutive equation to relate strain to stress, the tissue microstructure is modeled within a representative volume element (RVE) and the macroscopic response at any point in the tissue is determined by solving a micromechanics problem in the RVE. The model was applied successfully to acellular collagen gels, native blood vessels, and electrospun polyurethane scaffolds and provided accurate predictions for permeability calculations in isotropic and oriented fiber networks. The agreement of model predictions with experimentally determined mechanical properties provided insights into the mechanics of tissues and tissue constructs, while discrepancies revealed limitations of the model framework.

  7. Surgeon Major Thomas Heazle Parke (1857-1893): Irish doctor, soldier and explorer.

    Science.gov (United States)

    Parke, Andrew

    2017-08-08

    Surgeon Major Thomas Heazle Parke (1857-1893) was a doctor from Drumsna, County Roscommon, who after completing his education at the Royal College of Surgeons in Ireland joined the British army as a medical officer. After several years of serving in Ireland and Egypt, he volunteered to be medical officer of the Emin Pasha Relief Expedition of 1887-1889. This was to become Henry Morton Stanley's largest, longest and most controversial African expedition. The epic journey saw Stanley, his eight European officers and 800 African porters take almost 3 years to cross the African continent from West to East via the Congo River, Southern Sudan and Uganda. During this time, Parke had to single-handedly deal with the myriad diseases and injuries that beset the expedition's members. Barely 200 of the Zanzibari, Sudanese and Somali porters survived, and two British officers also perished. In completing the expedition, Parke became the first Irishman to cross Africa, and he had also become the first European to lay eyes on the ' Mountains of the Moon ' or ' Ruwenzori '. He returned home to great acclaim, and was bestowed copious honours and fellowships. His account of the expedition, My Experiences in Equatorial Africa , was a bestseller. However, his own health never recovered from the hardships of his time in Africa, and he died suddenly in 1893. His statue stands outside the Natural History Museum in Dublin. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  8. Musicality as an Aesthetic Process of Filtering in Thomas W. Shapcott's Poetry

    Directory of Open Access Journals (Sweden)

    Muslim Abbas Eidan Al-Ta'an

    2017-11-01

    Full Text Available How does music transcend individual experience? Is music the filter to purify everything? How does everything in the poet become music? Such questions are raised, now and then, by the conscious reader of poetry in general and that of the Australian poet Thomas W. Shapcott in particular. My present research-paper attempts to present an answer for these questions via probing the individuality of Shapcott's poetic experience and how does the poet's personal and experimental musicality as an artistic motif and aesthetic perspective play a key role in purifying language of its lies and its daily impurities. In the first place, my account is apt to find an aesthetic meaning for the action of transcending the individual experience in selected poems written by Shapcott. The philosophical and ritual thought of musicality is interplayed with the aesthetic power of poetry. Both aesthetic energies stem from the individual experience of the poet to transcend the borders of individuality and being absorbed and saturated in the wide pot of human universality. In other words, the poem after being filtered and purified musically and aesthetically is no longer an individual experience owned by its producer only, rather it becomes a human experience for its conscious readers. Music as a motif and meaning, regardless of its technical significance, is controversial in Shapcott's poetic diction. Music, here, is not a mere artistic genre; rather it is a ritualistic and philosophical thought. The paper is to investigate how Shapcott's musicality is constructed on aesthetics of balance and conformity in poetry and life.

  9. Thomas Graham Brown (1882--1965), Anders Lundberg (1920-), and the neural control of stepping.

    Science.gov (United States)

    Stuart, Douglas G; Hultborn, Hans

    2008-11-01

    Thomas Graham Brown (1882--1965) undertook experiments on the neural control of stepping in the University of Liverpool laboratory of Charles Sherrington (1857--1952) in 1910--13 and his own laboratory in 1913--15 at the University of Manchester. His results revealed the intrinsic capability of the spinal cord in the guinea pig and cat to generate a stepping output pattern whose timing did not depend upon descending or sensory inputs. This idea was then revolutionary because the prevailing viewpoint was that the stepping rhythm was generated by spinal reflexes. Sadly, Graham Brown's GBR peers gave little credence to this seminal accomplishment, except perhaps Sherrington, who waxed but largely waned on the potential significance of the work. It remained for the Swedish neuroscientist, Anders Lundberg (1920-), to rescue Graham Brown's concepts from obscurity: in seminars presented in several countries between 1957 and 1980, and in widely read articles and reviews (1965--1981). Graham Brown had proposed mutually inhibitory connections between a pair of intrinsically active flexor and extensor "half-centers" on each side of the spinal cord, with the rhythmic output modulated by sensory proprioceptive input. Lundberg, Elzbieta Jankowska (1930-), and their colleagues provided seminal, compelling evidence for spinal half-center interneuronal circuitry implicated in the control of stepping and Lundberg and Ingemar Engberg (1935--2005) made behavioral EMG observations on unrestrained cats that supported a central generation of the rhythm. Subsequently, models of the spinal pattern generators for mammalian locomotion have become progressively more complex but they mostly still include a half-center component.

  10. The botanical legacy of Thomas Hardwicke’s journey to Srinagar in 1796

    Directory of Open Access Journals (Sweden)

    Ian M. Turner

    2015-01-01

    Full Text Available In 1796, Thomas Hardwicke travelled through northern India between what is now Fatehgarh in Uttar Pradesh and Srinagar in Uttarakhand. Hardwicke collected and described plants encountered and had many of the plants illustrated from life. He published an account of the journey in 1799 including a list of plant species. I review the names validated in the original paper, and also those published subsequently by Sir James Edward Smith and William Roxburgh based partly or wholly on the material or drawings acquired by Hardwicke on the journey to Srinagar. The large collection of Hardwicke plant drawings now held in the British Library, and a smaller set in the Botany Library of the Natural History Museum, are considered in relation to the application and typification of plant names related to Hardwicke’s botanical exploration in India. The names of seven plant species were validly published in the 1799 paper (Androsace rotundifolia Hardw., Ficus laminosa Hardw., Justicia thyrsiformis Roxb. ex Hardw., Linum trigynum Roxb. ex Hardw., Lonicera quinquelocularis Hardw., Salvia integrifolia Roxb. ex Hardw. and Volkameria bicolor Hardw., plus one new combination (Echites antidysentericus (L. Roxb. ex Hardw.. As concluded by Britten more than a century ago, Ficus laminosa is the correct name for the fig variously referred to F. saemocarpa Miq. or F. squamosa Roxb. Smith based Rhododendron arboreum Sm. and Bignonia undulata Sm. on Hardwicke plants. At least a dozen Roxburgh names, including Crataegus integrifolia Roxb., Gardenia tetrasperma Roxb. and Morus serrata Roxb., are based, at least partly, on Hardwicke’s collections. In total, 23 names are lectotypified here and one neotype is designated.

  11. TOMÁS DE AQUINO Y LA TEOLOGÍA POSITIVA THOMAS AQUINAS AND POSITIVE THEOLOGY

    Directory of Open Access Journals (Sweden)

    Julio Antonio Castello Dubra

    2011-09-01

    Full Text Available A lo largo de su obra Tomás es coherente en sostener que no conocemos acerca de Dios qué es, sino más bien qué no es. No tenemos un conocimiento directo de la esencia divina en esta vida. Sin embargo, a partir del De potentia y en la Suma teológica, Tomás argumenta que los nombres que designan las perfecciones divinas –ser, bondad, sabiduría, etc.– no son términos meramente negativos o relacionales, sino que se dicen substantialiter de Dios, esto es, que significan la sustancia divina misma, aunque imperfectamente. El trabajo intenta analizar cuál es el status del tipo de conocimiento que presupone esa atribución, y qué implicancias tiene para la evaluación del carácter negativo o positivo de la teología natural de Tomás.Throughout his work Aquinas is consistent in holding that, about God, we do not know what He is but rather what He is not. We do not have a direct knowledge of divine essence in this life. However, from his De potentia onwards, and in the Summa theologiae, Thomas argues that the names which mean divine perfections –being, goodness, wisdom and the like– are not merely negative or relational terms, but are predicated substantialiter of God. That means they signify the very divine substance, though imperfectly. The paper tries to analyze what type of knowledge this attribution presupposes, and according to this, to what extent his natural theology can be assessed as negative or positive.

  12. Hardwiring Stem Cell Communication through Tissue Structure.

    Science.gov (United States)

    Xin, Tianchi; Greco, Valentina; Myung, Peggy

    2016-03-10

    Adult stem cells across diverse organs self-renew and differentiate to maintain tissue homeostasis. How stem cells receive input to preserve tissue structure and function largely relies on their communication with surrounding cellular and non-cellular elements. As such, how tissues are organized and patterned not only reflects organ function, but also inherently hardwires networks of communication between stem cells and their environment to direct tissue homeostasis and injury repair. This review highlights how different methods of stem cell communication reflect the unique organization and function of diverse tissues. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Hardwiring stem cell communication through tissue structure

    Science.gov (United States)

    Xin, Tianchi; Greco, Valentina; Myung, Peggy

    2016-01-01

    Adult stem cells across diverse organs self-renew and differentiate to maintain tissue homeostasis. How stem cells receive input to preserve tissue structure and function largely relies on their communication with surrounding cellular and non-cellular elements. As such, how tissues are organized and patterned not only reflects organ function but also inherently hardwires networks of communication between stem cells and their environment to direct tissue homeostasis and injury repair. This review highlights how different methods of stem cell communication reflect the unique organization and function of diverse tissues. PMID:26967287

  14. Learning Networks, Networked Learning

    NARCIS (Netherlands)

    Sloep, Peter; Berlanga, Adriana

    2010-01-01

    Sloep, P. B., & Berlanga, A. J. (2011). Learning Networks, Networked Learning [Redes de Aprendizaje, Aprendizaje en Red]. Comunicar, XIX(37), 55-63. Retrieved from http://dx.doi.org/10.3916/C37-2011-02-05

  15. Antoine Thomas, SI as a «Patient» of the Kangxi Emperor (r. 1662-1722: A Case Study on the Appropriation of Theriac at the Imperial Court

    Directory of Open Access Journals (Sweden)

    Puente-Ballesteros, Beatriz

    2012-06-01

    Full Text Available In this article I shall concentrate on Antoine Thomas’ illness and death (July 28, 1709 in Peking. This will serve as a case study to elucidate certain aspects of the role played by Jesuit medicine, i.e. Jesuit physicians and Jesuit drugs, at the court of the Kangxi emperor (r. 1662-1722, the first of the three great rulers of the Qing dynasty (1644-1911. As a first step the network of power, as reflected in the so-called medical palace memorials, will be presented in order to arrive at a more comprehensive evaluation of the medical involvement of the Jesuits, as practising physicians, suppliers of foreign drugs and as patients. It will be shown that the circumstances of Thomas’ illness and death must be based on a political and social analysis of the role of court medicine as patronised by the Kangxi emperor. Secondly, the case study of Antoine Thomas will also allow us to reflect on the delocalisation and appropriation of theriac at the Chinese court - one of the foreign drugs in the supply of which Jesuits might have been participated. Last but not least, I shall introduce a number of references in archival documents which throw some additional light on Thomas’ illness and death, and how they were perceived and dealt with in the imperial court.

    En el presente artículo me centro en la enfermedad y muerte de Antoine Thomas (28 de Julio, 1709 en Beijing. Lo cual servirá como estudio para aclarar ciertos aspectos del papel jugado por la medicina Jesuita, es decir, médicos Jesuitas y medicinas Jesuitas en la corte del emperador Kangxi (r. 1662-1722, el primero de los tres grandes emperadores de la dinastía Qing (1644-1911. Primero se presentará la red de poder, según se ve reflejada en los llamados memoriales de palacio de medicina, para poder llegar a una evaluación más profunda de la involucración médica de los Jesuitas, como médicos practicantes, proveedores de medicamentos extranjeros y como pacientes. Se demostrar

  16. Hydrodynamic theory of tissue shear flow

    CERN Document Server

    Popović, Marko; Merkel, Matthias; Etournay, Raphaël; Eaton, Suzanne; Jülicher, Frank; Salbreux, Guillaume

    2016-01-01

    We propose a hydrodynamic theory to describe shear flows in developing epithelial tissues. We introduce hydrodynamic fields corresponding to state properties of constituent cells as well as a contribution to overall tissue shear flow due to rearrangements in cell network topology. We then construct a constitutive equation for the shear rate due to topological rearrangements. We identify a novel rheological behaviour resulting from memory effects in the tissue. We show that anisotropic deformation of tissue and cells can arise from two distinct active cellular processes: generation of active stress in the tissue, and actively driven cellular rearrangements. These two active processes result in distinct cellular and tissue shape changes, depending on boundary conditions applied on the tissue. Our findings have consequences for the understanding of tissue morphogenesis during development.

  17. A network of networks.

    Science.gov (United States)

    Iedema, Rick; Verma, Raj; Wutzke, Sonia; Lyons, Nigel; McCaughan, Brian

    2017-04-10

    Purpose To further our insight into the role of networks in health system reform, the purpose of this paper is to investigate how one agency, the NSW Agency for Clinical Innovation (ACI), and the multiple networks and enabling resources that it encompasses, govern, manage and extend the potential of networks for healthcare practice improvement. Design/methodology/approach This is a case study investigation which took place over ten months through the first author's participation in network activities and discussions with the agency's staff about their main objectives, challenges and achievements, and with selected services around the state of New South Wales to understand the agency's implementation and large system transformation activities. Findings The paper demonstrates that ACI accommodates multiple networks whose oversight structures, self-organisation and systems change approaches combined in dynamic ways, effectively yield a diversity of network governances. Further, ACI bears out a paradox of "centralised decentralisation", co-locating agents of innovation with networks of implementation and evaluation expertise. This arrangement strengthens and legitimates the role of the strategic hybrid - the healthcare professional in pursuit of change and improvement, and enhances their influence and impact on the wider system. Research limitations/implications While focussing the case study on one agency only, this study is unique as it highlights inter-network connections. Contributing to the literature on network governance, this paper identifies ACI as a "network of networks" through which resources, expectations and stakeholder dynamics are dynamically and flexibly mediated and enhanced. Practical implications The co-location of and dynamic interaction among clinical networks may create synergies among networks, nurture "strategic hybrids", and enhance the impact of network activities on health system reform. Social implications Network governance requires more

  18. The Art of the Encounter, an Art of Distance: from Thomas Richards and Mario Biagini to Jerzy Grotowski

    Directory of Open Access Journals (Sweden)

    Yannick Butel

    2013-03-01

    Full Text Available This text presents the theatrical act as a passage, based on the observation of the actions of Thomas Richards and Mario Biagini that belong to a work protocol left by Jerzy Grotowski. This is the moment in which art as a vehicle, as Peter Brook wrote, merges with the art of the encounter. It is also the moment in which the experience transmitted by theatre causes the disappearance of boundaries and limits between scene, actor and spectator. The art of the encounter corresponds, then, to the inclusion of the spectator into the theatrical process which favours a return of the presence of oneself, the disappearance of self-estrangement.

  19. Fundamentación fitchteana de la ética y el problema del altruismo (Thomas Nagel)

    OpenAIRE

    Stolzenberg, Jürgen

    2007-01-01

    Este artículo confronta la fundamentación fichteana de la filosofía práctica con la ética del altruismo de Thomas Nagel. El esbozo que hace Nagel de una ética del altruismo parte de la evidencia que tiene una persona de ser sólo una entre otras, y de ahí deduce la exigencia de hacer el bien a los otros, sin poner en juego intereses propios. Este punto de vista universal presupone la decisión de orientarse conforme a normas universales. Esta decisión encuentra fundamentación suficien...

  20. BDDC Algorithms with deluxe scaling and adaptive selection of primal constraints for Raviart-Thomas vector fields

    KAUST Repository

    Oh, Duk-Soon

    2017-06-13

    A BDDC domain decomposition preconditioner is defined by a coarse component, expressed in terms of primal constraints, a weighted average across the interface between the subdomains, and local components given in terms of solvers of local subdomain problems. BDDC methods for vector field problems discretized with Raviart-Thomas finite elements are introduced. The methods are based on a deluxe type of weighted average and an adaptive selection of primal constraints developed to deal with coefficients with high contrast even inside individual subdomains. For problems with very many subdomains, a third level of the preconditioner is introduced.