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Sample records for network kingston ri

  1. Kingston Soundpainting Ensemble

    OpenAIRE

    Minors, Helen Julia; Kingston Soundpainting Ensemble

    2012-01-01

    This performance is designed to introduce teachers and school musicians to this live multidisciplinary live composing sign language.\\ud \\ud Led by Dr. Helen Julia Minors (soundpainter, trumpet, voice), the Kingston Soundpainting Ensemble, led by Dr. Minors at Kington University, is representated by a section a varied set of performers, using woodwind, brass, voice and percussion, spanning popular, classical and world styles. This performance consists of:\\ud \\ud Philip Warda (electronic instru...

  2. Transcriptome networks in the mouse retina: An exon level BXD RI database.

    Science.gov (United States)

    King, Rebecca; Lu, Lu; Williams, Robert W; Geisert, Eldon E

    2015-01-01

    Differences in gene expression provide diverse retina phenotypes and may also contribute to susceptibility to injury and disease. The present study defines the transcriptome of the retina in the BXD RI strain set, using the Affymetrix Mouse Gene 2.0 ST array to investigate all exons of traditional protein coding genes, non-coding RNAs, and microRNAs. These data are presented in a highly interactive database on the GeneNetwork website. In the Normal Retina Database, the mRNA levels of the transcriptome from retinas was quantified using the Affymetrix Mouse Gene 2.0 ST array. This database consists of data from male and female mice. The data set includes a total of 52 BXD RI strains, the parental strains (C57BL/6J and DBA/2J), and a reciprocal cross. In combination with GeneNetwork, the Department of Defense (DoD) Congressionally Directed Medical Research Programs (CDMRP) Normal Retina Database provides a large resource for mapping, graphing, analyzing, and testing complex genetic networks. Protein-coding and non-coding RNAs can be used to map quantitative trait loci (QTLs) that contribute to expression differences among the BXD strains and to establish links between classical ocular phenotypes associated with differences in the genomic sequence. Using this resource, we extracted transcriptome signatures for retinal cells and defined genetic networks associated with the maintenance of the normal retina. Furthermore, we examined differentially expressed exons within a single gene. The high level of variation in mRNA levels found among the BXD RI strains makes it possible to identify expression networks that underline differences in retina structure and function. Ultimately, we will use this database to define changes that occur following blast injury to the retina.

  3. Key geophysical indicators of seismic vulnerability in Kingston, Jamaica

    Science.gov (United States)

    Brown, L. A.; Hornbach, M. J.; Salazar, W.; Kennedy, M.

    2012-12-01

    Kingston, the major city and hub of all commercial and industrial activity in Jamaica, has a history of moderate seismic activity; however, two significant (>Mw 6) earthquakes (1692 and 1907) caused major devastation resulting in thousands of casualties. Both the 1692 and 1907 events also triggered widespread liquefaction and tsunamis within Kingston Harbor. Kingston remains vulnerable to these earthquakes today because the city sits on 200-m to 600-m thick alluvial fan deposits adjacent to the Enriquillo-Plantain Garden Fault—the same fault system that activated during the Haiti 2010 earthquake. Recent GPS results suggest the potential for a Mw 7-7.5 earthquake near Kingston along the Enriquillo- Plantain Garden fault Zone (EPGFZ), the dominant east-west trending fault through Jamaica. Whether active strands EPGFZ extend through downtown Kingston remains unclear, however, recent sonar mapping in Kingston harbor show evidence for active faulting, with offshore faults connecting to proposed active on-land fault systems that extend through populated areas of the city. Seismic "Chirp" reflections also shows evidence for multiple recent (Holocene) submarine slide deposits in the harbor that may be associated with historic tsunamis. Using recently acquired chirp and sediment cores, we are currently studying the recurrence interval of earthquake events. We also recently performed a microtremor survey to identify areas prone to earthquake-induced ground shaking throughout the city of Kingston & St. Andrew parish. Data was collected at 200 points with a lateral spacing of 500 metres between each point. Our analysis shows significant variations in the fundamental frequency across the city and results clearly indicate areas of potential amplification, with areas surrounding Kingston harbor (much of which has been built on reclaimed land) showing the highest potential for ground amplification. The microtremor analysis suggests several high-density urban areas as well as key

  4. The fauna of the Port Royal mangal, Kingston, Jamaica

    NARCIS (Netherlands)

    Alleng, Gerard P.

    1997-01-01

    ALLENG, Gerard P., 1997. The fauna of the Port Royal mangal, Kingston, Jamaica. Studies Nat. Hist. Caribbean Region 73, Amsterdam 1997: 23-42. An analysis and a characterization are presented of the Port Royal mangrove fauna. The existing literature on the subject is extensively reviewed and a fauna

  5. Hazardous Waste Cleanup: IBM Corporation in Kingston, New York

    Science.gov (United States)

    This site, approximately 258 acres in size, is located at Neighborhood Road in Kingston, New York. The site was first developed in the 1950s. Activities in the past were the development, manufacture, and testing of computer systems and the manufacture of

  6. Sedimentation and Flood assessment for the expansion of Kingston Harbour, Jamaica

    NARCIS (Netherlands)

    Kerssens, P.; Verreijken, K.; Vermerris, P.; Wijs, J.

    2012-01-01

    Student project report, in cooperation with Smith-Warner International Ltd. (SWIL), Kingston, Jamaica. At this moment the shipping channels in Kingston Harbour, Jamaica, slowly accrete. When the harbour is expanded, the local and global sediment transport is likely to change. During this project it

  7. "Words So Strong": Maxine Hong Kingston's "No Name Woman" Introduces Students to the Power of Words.

    Science.gov (United States)

    Petit, Angela

    2003-01-01

    Presents a powerful story that helps students to realize that words can order the world around them and form realities of their own. Attempts to capture the rich reading experiences that Kingston's "No Name Woman" offers to students developing an understanding of words so strong. Concludes that reflecting on Kingston's experiences,…

  8. RIKEN RI Beam Factory project

    Energy Technology Data Exchange (ETDEWEB)

    Yano, Yasushige; Goto, Akira; Katayama, Takeshi [Institute of Physical and Chemical Research, Wako, Saitama (Japan)

    1997-03-01

    The RARF proposes `RIKEN RI Beam Factory` as a next facility-expanding project. The factory makes it the primary aim to provide RI (Radioactive Isotope) beams covering over the whole atomic-mass range with the world-highest intensity in a wide energy range up to several hundreds MeV/nucleon. These RI beams are generated by the fragmentation of high-intensity heavy-ion beams. For the efficient production heavy-ion energies will be boosted up to over 100 MeV/nucleon even for very heavy ions by a K2500-MeV superconducting ring cyclotron serving as a post accelerator of the existing K540-MeV ring cyclotron. A new type of experimental installation called `MUSES` (Multi-USe Experimental Storage rings) will be constructed as well. With MUSES, various types of unique colliding experiments will become possible. (author)

  9. Life, Writing, and Peace: Reading Maxine Hong Kingston's The Fifth Book of Peace

    Directory of Open Access Journals (Sweden)

    Te-Hsing Shan

    2009-02-01

    Full Text Available Unlike her former award-winning and critically acclaimed works, Maxine Hong Kingston's The Fifth Book of Peace has received little attention. This is an unthinkable phenomenon for a writer who has been hailed as one of the most widely taught authors living in the United States. One of the main reasons is that critics and reviewers do not know how to cope with this complicated, heterogeneous, and "weird" text that defies easy categorization. Nor do they know how to respond to the ways the author urges her readers to squarely face collective American traumas and symptoms through writing (especially the Vietnam War. This paper attempts to approach this intriguing text from the perspective of life writing. Part I points out the undue neglect of this book, refutes some serious misunderstandings, and offers "life writing" as a critical approach. Part II places this book in the context of Kingston's career and life trajectory in order to show that "peace" has always been her major concern. Part III argues that, whereas the 1991 Berkeley-Oakland fire destroyed the manuscript of her "Fourth Book of Peace" along with her house, this "baptism of fire" and its accompanying sense of devastation generated a special empathy, enabling her to better understand those who suffer, especially Vietnam War veterans. Part IV deals with both the subjects of writing trauma and trauma narrative and indicates how Kingston combines her writing expertise with the Buddhist mindfulness expounded by the Vietnamese monk Thich Nhat Hanh to lead the Veterans Writing Workshop. Finally, Part V stresses how Kingston and her writing community, by combining life, writing, and peace, tell their own stories and create new lives both personally and collectively.

  10. Selenium bioaccumulation in fish exposed to coal ash at the Tennessee Valley Authority Kingston spill site.

    Science.gov (United States)

    Mathews, Teresa J; Fortner, Allison M; Jett, R Trent; Morris, Jesse; Gable, Jennifer; Peterson, Mark J; Carriker, Neil

    2014-10-01

    In December 2008, 4.1 million cubic meters of coal ash were released into the Emory and Clinch Rivers by the Tennessee Valley Authority Kingston Fossil Plant. Coal ash contains several contaminants, including the bioaccumulative metalloid selenium (Se). Because Se is predominantly accumulated in aquatic organisms through dietary rather than aqueous exposure, tissue-based toxicity thresholds for Se are currently being considered. The proposed threshold concentrations range between 4 μg/g and 9 μg/g Se (dry wt.) in whole body fish, with a proposed fillet threshold of 11.8 μg/g. In the present study, the authors examined the spatial and temporal trends in Se bioaccumulation and examined the relationship between the Se content in fillets and in whole bodies of fish collected around the Kingston spill site to determine whether Se bioaccumulation was a significant concern at the ash spill site. Whereas Se concentrations in fish (whole bodies and fillets) were elevated at sampling locations affected by the Kingston ash spill relative to reference locations, concentrations do not appear to be above risk thresholds and have not been increasing over the 5-yr period since the spill. These findings are not only relevant to guiding the human health and ecological risk assessments at the Kingston ash spill site, but because of current national discussions on appropriate guidelines for Se in fish as well for the disposal of coal combustion wastes, the results are also relevant to the general understanding of Se bioaccumulation in contaminated water bodies. © 2014 SETAC.

  11. Indoor air quality in 300 homes in Kingston/Harriman, Tennessee: winter phase status report

    Energy Technology Data Exchange (ETDEWEB)

    Hawthorne, A.R.; Uziel, M.; Vo-Dinh, T.; Cohen, M.A.; Orebaugh, C.T.; Miller, G.H.; Ironsides, K.; Monar, K.P.; Dudney, C.S.; Tyndall, R.L.

    1986-10-01

    This report summarizes the status of the 300-Home Kingston/Harriman Indoor Air Quality Study at the end of the winter phase of monitoring. Plans for the summer monitoring phase are also presented. The report is organized by the major pollutants monitored. Reporting focuses on study protocols and summaries of winter monitoring activities. A minimum of results are presented since, for many pollutants, laboratory analyses are not yet complete.

  12. Outreach and Education with Europlanet 2020 RI

    Science.gov (United States)

    Heward, Anita R.; Barrosa, Mariana; Europlanet 2020 RI

    2016-10-01

    Since 2005, Europlanet has provided a framework to bring together Europe's widespread planetary science community. The project has evolved through a number of phases, and currently comprises a Research Infrastructure (RI) funded through the European Commission's Horizon 2020 program, as well as a self-sustaining membership organization. Launched in September 2015, Europlanet 2020 RI provides support, services, access to facilities, new research tools and a virtual planetary observatory. Europlanet 2020 RI's outreach and education program aims to engage members of the public, schools, teachers, policy makers and industrial partners across Europe with planetary science and the opportunities that it provides for innovation, inspiration and job creation. Europlanet's outreach and education activities are led by Science Office Ltd, a Portuguese-based SME, and a network of partners spread across nine countries including University College London, the University of Leiden, University of Latvia, Vilnius University, the Institute of Accelerating Systems and Applications, the Observatoire de Paris, CAB-INTA and the Austrian Space Forum.Europlanet supports educators and outreach providers within the planetary science community by organizing meetings, best practice workshops and communication training sessions, offering a seed-funding scheme for outreach activities, and awarding an annual prize for public engagement. Europlanet is also developing its own education and outreach resources, including an animation on 'Jupiter and its Icy Moons' (the first in a series of video "shorts") and kits for hands-on comparative planetology activities. The Europlanet Media Centre uses traditional and social media channels to communicate newsworthy results and activities to diverse audiences in Europe and worldwide. Using tools like Google Hangouts, the project connects planetary researchers directly with the public and school groups. In addition, Europlanet engages with policy makers in the

  13. RIKEN RI Beam Factory Project

    CERN Document Server

    Yano, Yasushige

    2005-01-01

    The world-top-class radioactive-isotope-beam (RIB) facility, which is called ?RI beam factory (RIBF)?, is under construction at RIKEN. This facility is based on the so-called ?in-flight RI beam separation? scheme. Late in 2006, a new high-power heavy-ion accelerator system consisting of a cascade of three ring cyclotrons with K=570 MeV (fixed frequency, fRC), 980 MeV (Intermediate stage, IRC) and 2500 MeV (superconducting, SRC), respectively, will be commissioned. This new accelerator system will boost energies of the output beams from the existing K540-MeV ring cyclotron up to 440 MeV/nucleon for light ions and 350 MeV/nucleon for very heavy ions. These energetic heavy-ion beams are converted into intense RI beams via the projectile fragmentation or in-flight fission of uranium ions by the superconducting isotope separator, BigRIPS, under construction. The combination of the SRC and BigRIPS will expand our nuclear world into presently unreachable region. Major experimental installations are under priority di...

  14. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells.

    Science.gov (United States)

    Budke, Brian; Logan, Hillary L; Kalin, Jay H; Zelivianskaia, Anna S; Cameron McGuire, William; Miller, Luke L; Stark, Jeremy M; Kozikowski, Alan P; Bishop, Douglas K; Connell, Philip P

    2012-08-01

    Homologous recombination serves multiple roles in DNA repair that are essential for maintaining genomic stability. We here describe RI-1, a small molecule that inhibits the central recombination protein RAD51. RI-1 specifically reduces gene conversion in human cells while stimulating single strand annealing. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319 that likely destabilizes an interface used by RAD51 monomers to oligomerize into filaments on DNA. Correspondingly, the molecule inhibits the formation of subnuclear RAD51 foci in cells following DNA damage, while leaving replication protein A focus formation unaffected. Finally, it potentiates the lethal effects of a DNA cross-linking drug in human cells. Given that this inhibitory activity is seen in multiple human tumor cell lines, RI-1 holds promise as an oncologic drug. Furthermore, RI-1 represents a unique tool to dissect the network of reaction pathways that contribute to DNA repair in cells.

  15. Presence of pRI1:

    DEFF Research Database (Denmark)

    Migura, Lourdes Garcia; Hasman, Henrik; Jensen, Lars Bogø

    2009-01-01

    This study focused on the molecular characterization of a small cryptic, mobilizable plasmid (6038 bp) sequenced from an E. faecium 9631160-1 of poultry origin. Sequence analysis of pRI1 revealed seven open reading frames. pRI1 contained an IS 100% identical to ISEfa4. This insertion element...... almost identical to the repA from the pEFNP1 and pKQ10 plasmids from E. faecium was also identified. Presence of the pRI1 replication initiation gene (rep) was analyzed in a panel of 159 E. faecium isolates of human and animal origin from different European countries, of which 60 tested positive...... for the presence of pRI1-rep. Conjugation experiments verified transfer of the pRI1 together with conjugative plasmids harboring resistance to vancomycin and streptogramin. The presence of pRI1 in enterococcal isolates geographically separated and from different origin demonstrates the ability of enterococci...

  16. ri Talveti luulevalimik hispaania keeles

    Index Scriptorium Estoniae

    2003-01-01

    Talvet, Jüri. Elegia Estonia y otros poemas : [luulevalimik] / tõlkinud Jüri Talvet ja Albert Lázaro Tinaut ; järelsõna Janika Kronberg. Valencia : Palmart Capitelum, 2002; Vt. ka Eesti Päevaleht, 13. jaan., lk. 16

  17. RI production plan using JMTR

    Energy Technology Data Exchange (ETDEWEB)

    Hori, Nao Hiko; Izumo, Hironobu; Kanno, Masaru; Nakagawa, Tetsuya; Kawamura, Hiro Shi [Japan Atomic Energy Agency, Ibaraki Ken (Japan)

    2008-11-15

    At Oarai Research and Development Center, Japan Atomic Energy Agency (JAEA) is advancing the plan of refurbishing Japan Materials Testing Reactor (JMTR) to start the operation from FY 2011. At the JMTR, the iridium-192 ({sup 192}Ir) source for the medical treatment as well as for the industrial using in the non destructive inspection has been irradiated. As one of effective use of the renewed JMTR, JAEA has a plan to product molybdenum-99 ({sup 99}Mo), a parent nuclide of technetium-99 ({sup 99m}Tc). {sup 99m}Tc is most commonly used as a radiopharmaceutical in the field of nuclear medicine. Furthermore, production of radioisotope (RI) for which increasing demand is expected, e.g. rhenium-188 ({sup 188}Re) which being expected as a cancer treatment medicine.

  18. Fish Health Studies Associated with the Kingston Fly Ash Spill, Spring 2009 - Fall 2010

    Energy Technology Data Exchange (ETDEWEB)

    Adams, Marshall [ORNL; Fortner, Allison M [ORNL

    2012-05-01

    On December 22, 2008, over 4 million cubic meters of fly ash slurry was released into the Emory River when a dike surrounding a solid waste containment area at the Tennessee Valley Authority's (TVA) Kingston Fossil Plant ruptured. One component of TVA's response to the spill is a biological monitoring program to assess short- and long-term ecological responses to the ash and associated chemicals, including studies on fish health and contaminant bioaccumulation. These studies were initiated in early Spring 2009 for the purposes of: (1) documenting the levels of fly ash-associated metals in various tissues of representative sentinel fish species in the area of the fly ash spill, (2) determining if exposure to fly ash-associated metals causes short, intermediate, or long-term health effects on these sentinel fish species, (3) assessing if there are causal relationships between exposure to metals and health effects on fish, (4) evaluating, along with information from other ecological and physicochemical studies, the nature and route of contaminant transfer though food chains into higher level consumers, (5) providing important information for the Ecological Risk Assessment (ERA) for the Kingston fly ash project, and (6) serving as an important technology information transfer or model study focused on how to best evaluate the environmental effects of fly ash (and related environmental stressors), not only at the Kingston site, but also at sites on other aquatic systems where coal-fired generating stations are located. This report presents the results of the first two years of the fish health study. To date, fish health and bioaccumulation studies have been conducted from Spring 2009 though Fall 2011 and includes 6 seasonal studies: Spring 2009, Fall 2009, Spring 2010, Fall 2010, Spring 2011, and Fall 2011. Both the Spring and Fall studies have focused on 3-4 sentinel fish species that represent different feeding habits, behaviors, and home ranges. In addition

  19. From WWII to Kingston, Ontario: The History of Queen's University School of Medicine, Division of Plastic and Reconstructive Surgery.

    Science.gov (United States)

    Chung, Karen; Wyllie, Kenneth; Davidson, John

    2016-01-01

    To describe the origin and development of the Division of Plastic and Reconstructive Surgery at the Queen's University School of Medicine (Kingston, Ontario). Resarch ethics board approval and privacy agreements from the Kingston General Hospital (KGH, Kingston, Ontario) medical archives were obtained. Primary and secondary data sources were identified. A systematic examination of newspaper archives, research literature, KGH medical advisory committee meeting minutes, and testimonies from Dr Kenneth Wyllie and Dr John Davidson were obtained. In 1949, Dr Albert Ross Tilley arrived at Queen's University in Kingston, Ontario. There, Tilley initiated the Burn Unit at the KGH and began monthly teaching during the academic semester. Ken Wyllie (Meds '55), Lloyd Carlson (Meds '57) and John Emery (Meds '57) were the notable progeny of his early initiatives. In 1963, Kenneth Wyllie founded the Division of Plastic and Reconstructive Surgery in Kingston, Ontario, having completed plastic surgery training in Toronto and Edinburgh with experiences in Stockholm (Sweden), Paris (France) and Baltimore (Maryland, USA). He was shortly joined by Pat Shoemaker (Meds '66). John Davidson (Meds '82) arrived in 1989, bringing an interest in microsurgery and critical inquiry to the division. Five notable surgeons, Cartotto (Meds '88), Watkins, Watters, Meathrel (Meds '03) and McKay, further enhanced the Division's clinical and academic mission. The collective activity of the Division of Plastic and Reconstructive Surgery at Queen's School of Medicine in its 66-year history has encouraged more than 40 others to pursue distinguished careers in the specialty throughout North America, including three past presidents of the Canadian Society of Plastic Surgeons.

  20. The lived experiences of adolescents with sickle cell disease in Kingston, Jamaica.

    Science.gov (United States)

    Forrester, Andrea Brown; Barton-Gooden, Antoinette; Pitter, Cynthia; Lindo, Jascinth L M

    2015-01-01

    To explore the lived experiences of adolescents with sickle cell disease, in Kingston, Jamaica. A descriptive qualitative design was used for this research. In-depth interviews were conducted with six adolescents with sickle cell disease at a Sickle Cell Unit operated by the University of the West Indies. Interviews were audiotaped, transcribed, and thematically analyzed. The majority of the adolescents demonstrated a positive self-concept. They reported strong family, school, and peer support which made them feel accepted. All were actively engaged in social activities such as parties, but had challenges participating in sporting activities. Various coping strategies were utilized to address challenges of the disease including praying, watching television, and surfing the Internet. Sickle cell disease can be very challenging for the adolescent, but with positive self-concept and increased social support, especially from family and peers, these adolescents were able to effectively cope with their condition and live productive lives.

  1. Stress, Burnout and Coping among Emergency Physicians at a Major Hospital in Kingston, Jamaica.

    Science.gov (United States)

    Hutchinson, T A; Haase, S; French, S; McFarlane, T A

    2014-06-01

    The study examined the prevalence of stress, burnout, and coping, and the relationship between these variables among emergency physicians at a teaching hospital in Kingston, Jamaica. Thirty out of 41 physicians in the Emergency Department completed the Maslach Burnout Inventory, Perceived Stress Scale, Ways of Coping Questionnaire, and a background questionnaire. Descriptive statistical analyses were conducted. Fifty per cent of study participants scored highly on emotional exhaustion; the scores of 53.3% also indicated that they were highly stressed. Stress correlated significantly with the emotional exhaustion and depersonalization components of burnout. Depersonalization was significantly correlated with two coping strategies: escape-avoidance and accepting responsibility; emotional exhaustion was also significantly correlated with escape-avoidance. Emergency physicians at the hospital scored high on stress and components of burnout. Interventions aimed at reducing the occupational contributors to stress and improving levels of coping will reduce the risk of burnout and enhance psychological well-being among emergency physicians.

  2. The Kingston Allergy Birth Cohort: Exploring parentally reported respiratory outcomes through the lens of the exposome.

    Science.gov (United States)

    North, Michelle L; Brook, Jeffrey R; Lee, Elizabeth Y; Omana, Vanessa; Daniel, Nadia M; Steacy, Lisa M; Evans, Greg J; Diamond, Miriam L; Ellis, Anne K

    2017-04-01

    The Kingston Allergy Birth Cohort (KABC) is a prenatally recruited cohort initiated to study the developmental origins of allergic disease. Kingston General Hospital was chosen for recruitment because it serves a population with notable diversity in environmental exposures relevant to the emerging concept of the exposome. To establish a profile of the KABC using the exposome framework and examine parentally reported respiratory symptoms to 2 years of age. Data on phase 1 of the cohort (n = 560 deliveries) were compiled, and multivariate Cox proportional hazards regression models were used to determine associations with respiratory symptoms. The KABC exhibits diversity within the 3 exposome domains of general external (socioeconomic status, rural or urban residence), specific external (cigarette smoke, breastfeeding, mold or dampness), and internal (respiratory health, gestational age), as well as significant associations between exposures from different domains. Significant associations emerged between parental reports of wheeze or cough without a cold and prenatal cigarette smoke exposure, mold or dampness in the home, and the use of air fresheners in the early-life home environment. Breastfeeding, older siblings, and increased gestational age were associated with decreased respiratory symptoms. The KABC is a unique cohort with diversity that can be leveraged for exposomics-based studies. This study found that all 3 domains of the exposome had effects on the respiratory health of KABC children. Ongoing studies using phase 1 of the KABC continue to explore the internal exposome through allergy skin testing and epigenetic analyses and the specific external domain through in-home environmental analyses, air pollution modeling, and ultimately potential convergences within and among domains. Copyright © 2017 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  3. Armsad vanad asjad / Jüri Kuuskemaa

    Index Scriptorium Estoniae

    Kuuskemaa, Jüri, 1942-

    2003-01-01

    Kunstiajaloolane Jüri Kuuskemaa hiina portselanist esemetest oma kollektsioonis - taldrik kolme Tao geeniusega 17. saj.lõpust, mütoloogiline viie olemusega loom Chilin ja tee transportimiseks mõeldud sinise maalinguga vaasid

  4. Richard Antiku kunstikiindumus / Jüri Hain

    Index Scriptorium Estoniae

    Hain, Jüri, 1941-

    2011-01-01

    Arvustus:Raamatu valgusel. Richard Antik 100. Artikleid ja bibliograafia. Koostanud Merike Kiipus ja Piret Noorhani. Tartu : Eesti Kirjandusmuuseum, 2001. Ka Richard Antiku tegevusest kollektsionääri, näitustekorraldaja, kunstikaupmehe ning kunstikriitikuna

  5. Domik Petra / Jüri Kuuskemaa

    Index Scriptorium Estoniae

    Kuuskemaa, Jüri, 1942-

    2006-01-01

    Kunstiajaloolane Jüri Kuuskemaa tutvustab Peeter I majamuuseumi Kadriorus. Maja ajaloost, sisustusest (mööbel, kunstiesemed). Keldriruumis eksponeeritud Salomon Zeltrechti ja tema abiliste poolt tehtud kivibüstidest

  6. Riñón supernumerario

    OpenAIRE

    María del Pilar Quesada Marrero; Pilar Laborí Quesada; Elizabeth Leonarda Cárdenas Quao

    2014-01-01

    El riñón supernumerario es una anomalía congénita rara, en la cual existe un tercer riñón pequeño y rudimentario, con su cápsula propia y con una vascularización independiente a la del riñón del mismo lado. Se presenta el caso de un paciente del sexo masculino de 58 años de edad con la presencia de riñón supernumerario, el mismo se detectó como hallazgo accidental en la realización de una ecografía renal, como examen de rutina. Los exámenes diagnósticos utilizados fueron ecografía renal y tom...

  7. Evaluating the Effects of the Kingston Fly Ash Release on Fish Reproduction: Spring 2009 - 2010 Studies

    Energy Technology Data Exchange (ETDEWEB)

    Greeley Jr, Mark Stephen [ORNL; Adams, Marshall [ORNL; McCracken, Kitty [ORNL

    2012-05-01

    On December 22, 2008, a dike containing fly ash and bottom ash at the Tennessee Valley Authority's (TVA) Kingston Fossil Plant in East Tennessee failed and released a large quantity of ash into the adjacent Emory River. Ash deposits from the spill extended 4 miles upstream of the facility to Emory River mile 6 and downstream to Tennessee River mile 564 ({approx}8.5 miles downstream of the confluence of the Emory River with the Clinch River, and {approx}4 miles downstream of the confluence of the Clinch River with the Tennessee River). A byproduct of coal combustion, fly ash contains a variety of metals and other elements which, at sufficient concentrations and in specific forms, can be harmful to biological systems. The ecological effects of fly ash contamination on exposed fish populations depend on the magnitude and duration of exposure, with the most significant risk considered to come from elevated levels of certain metals in the ash, particularly selenium, on fish reproduction and fish early life stages (Lemly 1993; Besser and others 1996). The ovaries of adult female fish in a lake contaminated by coal ash were reported to have an increased frequency of atretic oocytes (dead or damaged immature eggs) and reductions in the overall numbers of developing oocytes (Sorensen 1988) associated with elevated body burdens of selenium. Larval fish exposed to selenium through maternal transfer of contaminants to developing eggs in either contaminated bodies of water (Lemly 1999) or in experimental laboratory exposures (Woock and others 1987, Jezierska and others 2009) have significantly increased incidences of developmental abnormalities. Contact of fertilized eggs and developing embryos to ash in water and sediments may also pose an additional risk to the early life stages of exposed fish populations through direct uptake of metals and other ash constituents (Jezierska and others 2009). The establishment and maintenance of fish populations is intimately associated

  8. The Duchess of Kingston's Case, the ruling of Lord Mansfield and duty of medical confidentiality in court.

    Science.gov (United States)

    Mendelson, Danuta

    2012-01-01

    The aim of this article is to demonstrate that the ruling commonly cited as the original precedent(1) for the doctrine that, at common law, medical practitioners' duty of confidentiality to their patients does not apply to court testimony,(2) did not, in fact, establish any such theory. The ruling by Lord Mansfield was made in the context of cross-examination by the Crown of a medical witness in the course of the trial of the Duchess of Kingston (Duchess of Kingston's Case (1776) 20 Howell's State Trials 355; [1775-1802] All ER Rep 623; [1776] 1 Leach 146), and this article will look briefly at: (1) the fascinating life of Elizabeth Chudleigh, the Dowager Duchess of Kingston, and the main events that led to her trial for bigamy; (2) the cross-examination of Caesar Hawkins and the different perceptions of the scope of confidentiality held by 18th century lawyers on the one hand and medical practitioners on the other; (3) Lord Mansfield's ruling that witnesses cannot withhold from the court facts which the law considers to be in the public domain; (4) the subsequent wide interpretation, usually as judicial obiter dicta, of its final paragraph during the 19th century, including early jurisprudential responses to the principle of medical confidentiality; and (5) the influence of John Henry Wigmore's opposition to patients' evidentiary privilege at common law during the twentieth century. Copyright © 2012. Published by Elsevier Ltd.

  9. Family relations, peer influence, spirituality and drug use among students in one university in Kingston, Jamaica

    Directory of Open Access Journals (Sweden)

    Howard Gough

    2015-01-01

    Full Text Available Este estudio busca clarear la relacion entre las relaciones familiares, la influencia de los pares, la espiritualidad y el uso de drogas en estudiantes de una Universidad en Kingston, Jamaica. Es un estudio de corte transversal utilizando datos cuantitativos de 335 estudiantes del pregrado, utilizando un cuestionario llenado por los estudiantes. La muestra fue compuesta de 335 estudiantes (69% sexo masculino y 31% sexo femenino entre las idades de 18-24 anos. Los 77.6% de los estudiantes de la muestra informaran ter utilizado drogas en el ano anterior. Una correlaccion positiva fue identificada entre el uso de cannabis en el ano anterior y tener una relacion familiar disfunccional y estresante (p<.05; y correlaciones negativas entre el uso en el ano anterior de alcohol, fumar e cannabis y positive para influencia de pares (p<.05, bien como para niveles alto de espiritualidad (p<.01. Una relacion familiar buena fue un factor protetor contra el uso de cannabis, encuanto la influencia positiva de pares y alto nivel de espiritualidad fueran factores positivos contra el uso de alcohol, fumar, y cannabis entre estudiantes que participaran en la investigacion.

  10. Histological chorioamnionitis associated with preterm prelabour rupture of membranes at Kingston General Hospital: a practice audit.

    Science.gov (United States)

    Magee, Bryden; Smith, Graeme

    2013-12-01

    To determine the prevalence of histological chorioamnionitis associated with preterm prelabour rupture of membranes (PPROM) in women following spontaneous onset of labour, urgent delivery or planned delivery after 34 weeks' gestation. Charts of all women admitted to Kingston General Hospital with PPROM prior to 34 weeks' gestation over five years were collected. Obstetrical outcomes and histopathology reports were reviewed. Two hundred forty-four women with PPROM were identified and reviewed. The majority of women (169; 69%) went into spontaneous labour and, of those, 24 (14%) had clinical chorioamnionitis and 79 (47%) had histological chorioamnionitis. Of the 45 women (18%) who required urgent delivery, 27 (60%) had clinical chorioamnionitis and 31 (69%) had histological chorioamnionitis. Only 26 of the original 244 women with PPROM (11%) were managed expectantly until 34 weeks' gestation and then had a planned delivery. The prevalence of histological chorioamnionitis in this group whose placentas were sent for histopathologic review was 24%. Overall, the clinical suspicion of chorioamnionitis was found to be specific (91%) but not sensitive (37%) for identifying chorioamnionitis on the basis of histopathology. Histological chorioamnionitis complicates almost one half of all cases of PPROM that occur prior to 34 weeks' gestation. Most women will progress to spontaneous labour or require urgent delivery for clinical chorioamnionitis or other complications related to ruptured membranes before reaching 34 weeks' gestation. Only a subset of women remain pregnant long enough to have labour induced, but among those the prevalence of histological chorioamnionitis is lower (24%).

  11. MEMOIRS OF A GIRLHOOD AMONG GHOSTS WRITTEN BY MAXINE HONG KINGSTON

    Directory of Open Access Journals (Sweden)

    Desy Khrisdiyanti

    2017-04-01

    Full Text Available Every generation brings their own voice, no matter how rigorous the elderly retain the cultural values of their ancestors. A novel written by Maxine Hong Kingston –a Chinese American descent- entitled The Woman Warrior: Memoirs of a Girlhood among Ghosts, portraits her struggle to get her own identity between her Chinese and her American identity. A descriptive library research was conducted to reveal the reasons that the Chinese American descents struggled to survive in between both lives. Interdisciplinary approaches are employed to analyze the data in order to obtain comprehensive analysis, among others: psychological, sociological, and literary approaches. Psychological approach is to expound the emotional perspectives of the character shifts. Sociological approach is applied to discuss the socialization process and its connection to the character shift. Likewise, literary approach is to uncover the structure of the work which was the result of Kingston‘s experience and reflection of the phenomena in her real life. The research concludes that the personality change of the Chinese American descents is due to their historical, social, economical, and educational experience. Furthermore, the descents tend to transform their traits closer to the white‘s, which have been their counterpart in the new land, than to their ancestries‘.

  12. Bioaccumulation Studies Associated with the Kingston Fly Ash Spill, Spring 2009 - Fall 2010

    Energy Technology Data Exchange (ETDEWEB)

    Adams, Marshall [ORNL; Brandt, Craig C [ORNL; Fortner, Allison M [ORNL

    2012-05-01

    In December 2008, an ash dike at the Tennessee Valley Authority (TVA) Kingston Fossil Plant ruptured, releasing over one billion gallons of coal fly ash into the Emory and Clinch Rivers. Coal fly ash may contain several contaminants of concern, but of these selenium (Se) and arsenic (As) have been highlighted because of their toxicity and tendency to bioaccumulate in aquatic food chains. To assess the potential impact of the spilled fly ash on humans and the environment, a comprehensive biological and environmental monitoring program was established, for which resident aquatic organisms (among other sample media) are collected to determine contaminant exposure and evaluate the risk to humans and wildlife. Studies on bioaccumulation and fish health are major components of the TVA Biological Monitoring Program for the Kingston fly ash project. These studies were initiated in early Spring 2009 for the purposes of: (1) documenting the levels of fly ash-associated metals in various tissues of representative sentinel fish species in the area of the fly ash spill, (2) determining if exposure to fly ash-associated metals causes short, intermediate, or long-term health effects on these sentinel fish species, (3) assessing if there are causal relationships between exposure (to metals) and effects on fish, (4) evaluating, along with information regarding other ecological and physicochemical studies, the nature and route of contaminant transfer though food chains into higher level consumers, (5) providing important information for the Ecological Risk Assessment (ERA) for the Kingston fly ash project, and (6) serving as an important technology transfer or model study focused on how to best evaluate the environmental effects of fly ash, not only at the Kingston site, but also at sites on other aquatic systems where coal-fired generating stations are located. This report summarizes the bioaccumulation results from the first two years of study after the fly ash spill, including

  13. Gender differences in simultaneous polydrug use among undergraduate students of one university, Kingston - Jamaica

    Directory of Open Access Journals (Sweden)

    Patrice Whitehorne-Smith

    2012-01-01

    Full Text Available Este estudio tuvo como objetivo explorar el patrón comparativo de policonsumo simultáneo de drogas entre géneros, en estudiantes de 1º y 2º año de pregrado en una universidad en Kingston, Jamaica. Hubo 295 participantes en el estudio (58 hombres y 237 mujeres de la Facultad de Ciencias Médicas de esta universidad local. El estudio utilizó un cuestionario auto-administrado en el que se abordaron diversos aspectos del consumo y poli-consumo simultáneo de drogas. Los resultados no-ajustados revelaron un significativo mayor nivel de policonsumo simultaneo en hombres que en mujeres 40,9% y 14,3% respectivamente en los últimos 12 meses (x², p=0,009 y en los últimos 30 días 8,9% vs. 1,7% (x², p=0,014. Estos resultados sugieren un predominio en el comportamiento de policonsumo simultáneo de drogas entre hombres estudiantes de pregrado en esta población comparado con mujeres, aunque se refiere investigación adicional.

  14. Policy Activities in Europlanet 2020 RI

    Science.gov (United States)

    Giacomini, L.; Heward, A.; Mason, N.

    2017-09-01

    The Europlanet 2020 Research Infrastructure (RI) has received 9.945 million Euros from the European Commission to integrate planetary science across Europe, provide access to facilities, develop tools and build community cohesion. To help these processes and to increase engagement between our policy makers and the planetary science community, part of Europlanet 2020 RI's efforts are dedicated to building connections and organising activities for and within the European Parliament. Since September 2015, Europlanet 2020 RI has contacted all 134 Members of the European Parliament (MEPs) on the ITRE Committee. More than 20 individual briefings have been held to date with MEPS and/or their representatives. In November 2016, Europlanet 2020 RI organized a very successful exhibition in the European Parliament as part of the 8th European Innovation Summit and the STOA Annual Lecture, and a dinner debates was held in the on the 'Impact of the EU on planetary science' in April 2016. These events enable members of the Europlanet community, politicians and interested parties to come together and discuss views on topics of interest or concern to the space and planetary sectors. Efforts in recent years have led to important opportunities for our community to feed into reporting and consultative processes. In this talk we will discuss the results achieved in the last two years of activities and the next steps foreseen by Europlanet 2020 RI.

  15. Medical RI development plan of KOMAC

    Science.gov (United States)

    Kim, Kye-Ryung; Jung, Myung-Hwan; Yoon, Sang-Pil; Min, Yi-Sub; Cho, Yong-Sub

    2017-12-01

    Many kinds of radioisotopes (RIs) produced by the high energy (100 200 MeV) proton accelerators are developed by the foreign R&D institutes and the worldwide demands are being increased continuously. The RI production using high energy proton beam higher than 50 MeV was not considerable because of the limit of the proton beam energy from existing proton accelerator facilities in Korea before 2013. The available maximum proton energy was 50 MeV from MC-50 cyclotron of Korea Institute of Radiological and Medical Sciences (KIRAMS) at that time. After the construction of a 100 MeV high-current and high-energy proton accelerator and a new irradiation facility for the RI production in 2013 and 2016 by the Korea Multi-purpose Accelerator Complex (KOMAC) at Korea Atomic Energy Research Institute (KAERI), we can make a plan for the new RI production of Cu-67, Sr-82 and so on. In the medical application fields, the worldwide demand of Sr-82 is being increased rapidly during last several years and the domestic demand of Cu-67 is also expected to be increased in near future. And alpha-emitters, such as Ac-225 and Ra-223, are becoming attractive to the users in the medical science fields in the future. The RI development plan of KOMAC was specified recently reflecting the recent environment changes and requirements from the users. In this paper, the results and present status of RI production and R&D facilities, calculation results related to the RI production yields, and future plans is presented.

  16. Tüüri vioolakontserdi esiettekanne

    Index Scriptorium Estoniae

    2008-01-01

    24. okt. toovad Taanis Sonderborgis maailmaesiettekandele Erkki-Sven Tüüri Vioolakontserdi "Illuminatio" norra vioolamängija Lars Anders Tomter ja Lõuna- Jüütimaa Sümfooniaorkester, mida juhatab Vladimir Ziva. Evelyn Glennie ja New Jersey Sümfooniaorkester Neeme Järvi juhatusel esitavad 10. okt. USAs Newarkis ja 12. okt. New Brunswickis Tüüri 4. sümfoonia "Magma". Sellega seoses esineb Tüür loengutega oma loomingust järgmistes kõrgkoolides: New York Univerdity, Juilliard Scool of Music, Princeton University ja Montclair State University

  17. Intravaginal Cleansing among Women Attending a Sexually Transmitted Infection Clinic in Kingston, Jamaica

    Science.gov (United States)

    Carter, M; Gallo, M; Anderson, C; Snead, MC; Wiener, J; Bailey, A; Costenbader, E; Legardy-Williams, J; Hylton-Kong, T

    2015-01-01

    Objectives Although common worldwide, intravaginal cleansing is associated with poor health outcomes. We sought to describe intravaginal cleansing among women attending a sexually transmitted infection (STI) clinic in Jamaica. Methods We examined intravaginal cleansing (“washing up inside the vagina”, douching, and products or materials used) among 293 participants in a randomized trial of counselling messages at an STI clinic in Kingston. We focussed on information on intravaginal cleansing performed in the 30 days and three days preceding their baseline study visit. We describe reported cleansing behaviours and used logistic regression to identify correlates of intravaginal cleansing. Results Fifty-eight per cent of participants reported intravaginal cleansing in the previous 30 days, and 46% did so in the three days before baseline. Among those who cleansed in the previous 30 days, 88% reported doing so for hygiene unrelated to sex, and three-fourths reported generally doing so more than once per day. Soap (usually with water) and water alone were the most common products used for washing; commercial douches or detergents were reported infrequently. Intravaginal cleansing in the three days before the baseline visit was positively associated with having more than one sex partner in the previous three months (adjusted odds ratio [AOR], 1.9; 95% CI, 1.1, 3.2), and negatively associated with experiencing itching in the genital area at baseline (AOR, 0.6; 95% CI, 0.4, 1.0). Conclusions A large proportion of women attending STI clinics in Jamaica engage in frequent intravaginal cleansing, indicating a need for clinicians to discuss this topic with them accordingly. PMID:24171329

  18. Incidence of childhood cancer in Kingston and St Andrew, Jamaica, 1983-2002.

    Science.gov (United States)

    Bishop, K L; Hanchard, B; Gibson, T N; Lowe, D; McNaughton, D; Waugh, N; Akinbebe, A

    2013-09-01

    There have been several modifications to the classification of childhood cancers since the first report (1968-1981) specific to the Jamaican paediatric population was published in 1988. This paper reports on paediatric cancer incidence in Kingston and St Andrew, Jamaica, for the 20-year period 1983-2002 based on these modifications. All cases of cancer diagnosed in children (0-14 years), between 1983 and 2002 were extracted from the Jamaica Cancer Registry archives and classified using the International Classification of Childhood Cancer, third edition. Incidence figures were calculated as per the International Agency for Research on Cancer (IARC) reporting format for childhood cancer. There were 272 cases (133 males, 139 females) of childhood cancer identified in the 20-year period. The overall age standardized rate (ASR) was 69.4 per million; that for males was 67.8 per million, and for females, 70.9 per million. The three most common malignancies overall were leukaemia (21.3%), lymphoma (15.8%) and brain and spinal neoplasms (14.0%). In males, the highest ASRs were seen for leukaemia (14.8 per million), lymphoma (12.7 per million), and brain and spinal neoplasms (8.2 per million), and in females, leukaemia (14.4 per million), nephroblastoma (11.3 per million), and brain and spinal neoplasms (10.6 per million). The rankings of the most common childhood malignancies in Jamaica (leukaemia, brain and spinal neoplasms and lymphomas) have shown few changes since the last review. However, there are differences in frequency and gender distribution of nephroblastoma and brain and spinal neoplasms.

  19. Migratsioonipoliitika innovatsiooni heaks / Jüri Pihl

    Index Scriptorium Estoniae

    Pihl, Jüri, 1954-

    2008-01-01

    Ilmunud ka: Narvskaja Gazeta 17. apr. lk. 6, Den za Dnjom 18. apr. lk. 19. Siseminister Jüri Pihli arvates võib kvalifitseeritud tööjõu puudus ohustada Eesti majanduse jätkusuutlikkust ja heaolu kasvu ning Eesti võiks heade spetsialistide otsingul vaadata ka Euroopa Liidust väljapoole

  20. Rahutused Nõukogude Liidus / Jüri Liim

    Index Scriptorium Estoniae

    Liim, Jüri

    1999-01-01

    Järg Nov/30/Dec/7;14;21 Mihhail Gorbatshov andis 1988. aastal vastavale KGB osakonnale korralduse, et talle valmistataks ette materjalid massilistest vastuhakkudest riigis 1957.-1988. aastatel. Alates 14. dets. ajalehes näidatud autor : Jüri Liim

  1. 76 FR 59596 - Anchorage Regulations; Newport, RI

    Science.gov (United States)

    2011-09-27

    ... size of anchorage ``D'' west of Goat Island, Newport, RI, to safely accommodate up to three cruise... water, water-sheet area, and density of vessel traffic in the vicinity of Newport west of Goat Island... Federal Government and Indian tribes, or on the distribution of power and responsibilities between the...

  2. Mass, black carbon and elemental composition of PM{sub 2.5} at an industrial site in Kingston, Jamaica

    Energy Technology Data Exchange (ETDEWEB)

    Boman, Johan, E-mail: johan.boman@chem.gu.se; Gaita, Samuel M.

    2015-11-15

    An estimated three million premature deaths yearly can be attributed to ambient particulate pollution, a majority of them in low and middle income countries. The rapid increase in the vehicle fleet in urban areas of the Caribbean countries have experienced contributes to the bad urban air quality. In this study aerosol particles with an aerodynamic diameter smaller than, or equal to, 2.5 μm (PM{sub 2.5}) were collected over 24 h at a site along Spanish Town Road, one of the main commuter roads in Kingston, Jamaica. The study was aimed at determining the mass, black carbon and elemental composition of PM{sub 2.5} in Kingston. Although lead in the gasoline was phased out in the year 2000, up to 5000 ppm of sulfur is still allowed in the diesel, leading to an extensive secondary particle formation. PM{sub 2.5} samples were collected using a Mini-vol sampler between 12 December 2013 and 21 March 2014 and analyzed for trace elements using the Particle-Induced X-ray Emission (PIXE) facility at Lund University, Sweden. Concentrations of Si, S, Cl, K, Ca, Ti, V, Cr, Fe, Ni, Cu, Zn, Br and Pb were determined. Elemental concentrations showed a high temporal variation and the average PM{sub 2.5} concentration (44 μg m{sup −3}) is higher than the air quality standards that apply in the European Union (25 μg m{sup −3}) and in the USA (12 μg m{sup −3}). From this we can conclude that the air quality in the area is severely influenced by PM{sub 2.5} pollution and that there is a need to develop plans for improving the air quality in Kingston city.

  3. Mass, black carbon and elemental composition of PM2.5 at an industrial site in Kingston, Jamaica

    Science.gov (United States)

    Boman, Johan; Gaita, Samuel M.

    2015-11-01

    An estimated three million premature deaths yearly can be attributed to ambient particulate pollution, a majority of them in low and middle income countries. The rapid increase in the vehicle fleet in urban areas of the Caribbean countries have experienced contributes to the bad urban air quality. In this study aerosol particles with an aerodynamic diameter smaller than, or equal to, 2.5 μm (PM2.5) were collected over 24 h at a site along Spanish Town Road, one of the main commuter roads in Kingston, Jamaica. The study was aimed at determining the mass, black carbon and elemental composition of PM2.5 in Kingston. Although lead in the gasoline was phased out in the year 2000, up to 5000 ppm of sulfur is still allowed in the diesel, leading to an extensive secondary particle formation. PM2.5 samples were collected using a Mini-vol sampler between 12 December 2013 and 21 March 2014 and analyzed for trace elements using the Particle-Induced X-ray Emission (PIXE) facility at Lund University, Sweden. Concentrations of Si, S, Cl, K, Ca, Ti, V, Cr, Fe, Ni, Cu, Zn, Br and Pb were determined. Elemental concentrations showed a high temporal variation and the average PM2.5 concentration (44 μg m-3) is higher than the air quality standards that apply in the European Union (25 μg m-3) and in the USA (12 μg m-3). From this we can conclude that the air quality in the area is severely influenced by PM2.5 pollution and that there is a need to develop plans for improving the air quality in Kingston city.

  4. ri Kraft / Jüri Kraft ; interv. Tiina Jõgeda

    Index Scriptorium Estoniae

    Kraft, Jüri, 1935-

    2004-01-01

    Autori meenutusi õpingutest Tartu Ülikooli majandusteaduskonnas, direktori ametist Sangaris ja Klementis, tööst kergetööstusministeeriumis ning ministrina. Lisatud Jüri Krafti olulisemad eluloolised andmed

  5. ri Ratas : Tallinnasse rahvuspark! / Jüri Ratas ; interv. Ilmar Palli

    Index Scriptorium Estoniae

    Ratas, Jüri, 1978-

    2005-01-01

    Tallinna uus linnapea Jüri Ratas rohelisest vööndist, keskkonnakaitsest, ohtlikest veostest, teede olukorrast, linna elukeskkonnast, asotsiaalide probleemist ning kohaliku omavalitsuse ja riigi koostööst

  6. ANALISIS FAKTOR-FAKTOR YANG MEMENGARUHI TRANSFORMASI KAPABILITAS ORGANISASI DAN PERAN BADAN PEMERIKSA KEUANGAN RI

    Directory of Open Access Journals (Sweden)

    Agus Joko Pramono

    2017-01-01

    Full Text Available ABSTRACT This study is aimed to study the influencing factors of the Audit Board of Republic Indonesia’s roles and capabilities transformation to meet the national development goals. This study use a qualitative approach with Analytic Network Process (ANP method, to map out the interrelated factors of nodes within 3 clusters, which are the external, internal, and supporting factors. Focus Group Discussion (FGD was conducted to design a Framework Analysis. The participants of the FGD were BPK RI officials and its stakeholders including relevant external experts. The FGD has made a quantification framework as an ideal approach to use for data processing on software superdecisions. This process has brought about the priorities as follows: external stakeholder engagement, leadership and governance system, communication and the management of information system. The research has found out that the most significant and urgent factor is the concern of, and support from, the external stakeholders for BPK RI. Therefore, BPK RI has to design a strategy and communication program that can effectively improve the external support and concern. Keywords: Transformation, organizational capability, organizational roles, The Audit  Board of Indonesia, Analytic Network Process. ABSTRAK Kajian ini bertujuan untuk mengkaji faktor-faktor yang berpengaruh terhadap transformasi kapabilitas dan peran Badan Pemeriksa Keuangan Republik Indonesia. Kajian ini menggunakan pendekatan kualitatif dengan metode Analytic Network Process (ANP untuk mendapatkan hubungan antar node dalam 3 cluster (faktor eksternal, internal dan penunjang yang bersifat network. Framework analysis disusun melalui FGD para pakar dari eksternal dan internal BPK RI. Kuantifikasi framework dihasilkan dari FGD para pakar internal BPK RI. Olah data pada software superdecisions menghasilkan prioritas-prioritas sebagai berikut: faktor eksternal prioritasnya Stakeholders Engagement; faktor internal

  7. 33 CFR 334.80 - Narragansett Bay, RI; restricted area.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Narragansett Bay, RI; restricted..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.80 Narragansett Bay, RI; restricted... regulations in this section shall be enforced by the Commander U.S. Naval Base, Newport, RI, and such agencies...

  8. The role of social factors in the use of licit drugs among university students from one university in Kingston, Jamaica

    Directory of Open Access Journals (Sweden)

    Rashalee Mitchell

    2015-01-01

    Full Text Available Investigación cuantitativa de tipo descriptiva-exploratoria, con diseño transversal que examinó el efecto moderador de ciertos factores socio-culturales en el consumo de drogas licitas entre estudiantes universitarios de una universidad en Kingston, Jamaica. La muestra non probabilistica fue conformada por 335 estudiantes de una universidad especifica de Kingston, Jamaica. Fue elaborado un cuestionario con cinco escalas ya validadas, que interrogaba sobre la influencia del grupo de pares, las relaciones familiares, el entretenimiento, la espiritualidad y el consumo de drogas. Se utilizó el programa SPSS versión 18 para el análisis estadística. Los datos indicaran que los respondientes con uno o mas anmigos que estaban involucrados con el uso de drogas eran 9.5 veces mas disponibles para fumar y dos veces mas para consumir alcole. Los respondientes que tinian baja espiritualidad eran dos veces mas proponientes para fumar y 1.3 veces mas proponientes de consumir alcole. Los datos indicaran haber asociacion significante entre los factores sociales y el consume de drogas licitas.

  9. Rembrandt Kadrioru lossis / Jüri Hain

    Index Scriptorium Estoniae

    Hain, Jüri, 1941-

    2000-01-01

    Kadrioru lossi kuppelsaali tundmatu meistri laemaali maalimise ajalugu. Maali aluseks on Rembrandti maal "Diana suplus". Laemaal on maalitud Magdalena de Passe (1600-1638) vasegravüüri põhjal, mis on tehtud Rembrandti maalist. Rembrandt on lähtunud Antonio Tempesta (1555-1630) kahest gravüürist, viimane on lähtunud Otto van Veeni (1556-1629) maalist

  10. EKSISTENSI DPR RI SETELAH AMANDEMEN UUD 1945

    Directory of Open Access Journals (Sweden)

    W.M. Herry Susilowati

    2006-01-01

    Full Text Available After the amendaments of UUD 1945 in 1999, 2000, 2001 and 2002, it is likely that Indonesia Parliament (DPR-RI has givers bord. It’s existence as an institution that has legislative, budget and control functions as well as interpellation, inquiry and expressing the opinions rights. Therefore, it is strongly expexted to be able to act as national institution that accomodates the people’s aspiration.

  11. A Study of RI Clusters Based on Symbiosis Theory

    Directory of Open Access Journals (Sweden)

    Wenchao Xu

    2017-03-01

    Full Text Available Research infrastructure (RI refers to a large and complex science research facility or system that conducts top-level science activities. In recent years, there has been a tendency toward geographical concentration of RIs and formation of RI clusters. Some of these RI clusters have become engines for regional social and economic development. It turns out that RI clusters present a new stage for RI sustainable development. The present paper tries to study RI clusters based on symbiosis theory in order to build an analytical framework for policy makers’ comprehensive understanding of RI clusters. Following the analytical framework, we study the symbiosis system and the symbiosis structures of an RI cluster by analyzing its major characteristics. In order to achieve a balanced symbiotic situation, a competitive model and a symbiosis model are proposed based on the Logistic Model. The analysis is grounded in the samples of China’s typical RI clusters and other cases in the world to give a vivid and convincing illustration. During the analysis process, an RI cluster is regarded as a complex ecological system and the organization and management of units in the cluster is the focus of the study. The authors hope that the paper will supplement the existing literature, which mainly focuses on the technological problems and the evaluation of RI’s socioeconomic effects, in the sense of a systematical analysis of the management problem of RI.

  12. Relationship between selenium body burdens and tissue concentrations in fish exposed to coal ash at the Tennessee Valley Authority Kingston spill site

    Energy Technology Data Exchange (ETDEWEB)

    Mathews, Teresa J [ORNL; Fortner, Allison M [ORNL; Jett, Robert T [ORNL; Peterson, Mark J [ORNL; Carriker, Neil [Tennessee Valley Authority (TVA); Morris, Jesse G [ORNL; Gable, Jennifer [Environmental Standards, Inc.

    2014-01-01

    In December 2008, 4.1 million m3 of coal ash were released into the Emory and Clinch Rivers by the Tennessee Valley Authority (TVA) Kingston Fossil Plant. Coal ash contains several contaminants, including the bioaccumulative metalloid selenium (Se). Because Se is predominantly accumulated in aquatic organisms through dietary, rather than aqueous exposure, tissue-based toxicity thresholds for Se are currently being considered. The proposed threshold concentrations range between 4-9 g/g Se (dry wt.) in whole body fish, with a proposed fillet threshold of 11.8 g/g. In the present study we examined the spatial and temporal trends in Se bioaccumulation and examined the relationship between the Se content in fillets and in whole bodies of fish collected around the Kingston spill site to determine whether Se bioaccumulation was a significant concern at the ash spill site. While Se concentrations in fish (whole bodies and fillets) were elevated at sampling locations affected by the Kingston ash spill relative to reference locations, concentrations do not appear to be above risk thresholds and have not been increasing over the five year period since the spill. Our results are not only relevant to guiding the human health and ecological risk assessments at the Kingston ash spill site, but because of current national discussions on appropriate guidelines for Se in fish as well for the disposal of coal combustion wastes, our results are also relevant to the general understanding of Se bioaccumulation in contaminated water bodies.

  13. Participants' perceptions of a lifestyle approach to promoting physical activity: targeting deprived communities in Kingston-Upon-Hull

    Directory of Open Access Journals (Sweden)

    Sleap Mike

    2006-08-01

    Full Text Available Abstract Background The health benefits of an active lifestyle have been extensively documented and generally accepted. In the UK, declining physical activity levels are a major contributing factor to a number of public health concerns such as obesity and coronary heart disease. Clearly, there is an urgent need to support people in developing sustainable active lifestyles. In 2003, a new lifestyle-based physical activity service called Active Lifestyles (AL was set up in Kingston-upon-Hull to help local residents to become more active and develop healthier lifestyles. The service targeted the most deprived communities in the city. The aim of the study was to explore participants' perceptions of the operation and effectiveness of the AL service. Methods Five focus groups were conducted in community centres and offices in the health promotion service in Kingston-upon-Hull. Sixteen white adult males (n = 5 and females (n = 11 participated in the study. Ages ranged from 15–73 years (mean age = 53 years. Data were analysed using a content analysis technique based on the 'framework' approach. Results Three broad themes emerged from the focus groups; the referral process; operational aspects of the AL service; and perceived benefits of the service. Overall, participants were extremely positive about the AL service. Many reported increased activity levels, modified eating habits, and enhanced awareness and education regarding healthier living. Most participants reported that local awareness of the AL service was low and greater promotion was required so more people could benefit. The success of the service was highly dependent upon the qualities and approach of the AL advisor. Conclusion The service appears to have filled a gap in service provision since it offered support to the most sedentary, older, unfit and overweight individuals, many of whom live in the most deprived parts of Kingston-upon-Hull. Traditional exercise referral schemes that focus

  14. Participants' perceptions of a lifestyle approach to promoting physical activity: targeting deprived communities in Kingston-upon-Hull.

    Science.gov (United States)

    Wormald, Helen; Waters, Heidi; Sleap, Mike; Ingle, Lee

    2006-08-04

    The health benefits of an active lifestyle have been extensively documented and generally accepted. In the UK, declining physical activity levels are a major contributing factor to a number of public health concerns such as obesity and coronary heart disease. Clearly, there is an urgent need to support people in developing sustainable active lifestyles. In 2003, a new lifestyle-based physical activity service called Active Lifestyles (AL) was set up in Kingston-upon-Hull to help local residents to become more active and develop healthier lifestyles. The service targeted the most deprived communities in the city. The aim of the study was to explore participants' perceptions of the operation and effectiveness of the AL service. Five focus groups were conducted in community centres and offices in the health promotion service in Kingston-upon-Hull. Sixteen white adult males (n = 5) and females (n = 11) participated in the study. Ages ranged from 15-73 years (mean age = 53 years). Data were analysed using a content analysis technique based on the 'framework' approach. Three broad themes emerged from the focus groups; the referral process; operational aspects of the AL service; and perceived benefits of the service. Overall, participants were extremely positive about the AL service. Many reported increased activity levels, modified eating habits, and enhanced awareness and education regarding healthier living. Most participants reported that local awareness of the AL service was low and greater promotion was required so more people could benefit. The success of the service was highly dependent upon the qualities and approach of the AL advisor. The service appears to have filled a gap in service provision since it offered support to the most sedentary, older, unfit and overweight individuals, many of whom live in the most deprived parts of Kingston-upon-Hull. Traditional exercise referral schemes that focus solely on facility-based exercise should be broadened to

  15. From WWII to Kingston, Ontario: The History of Queen’s University School of Medicine, Division of Plastic and Reconstructive Surgery

    Science.gov (United States)

    Chung, Karen; Wyllie, Kenneth; Davidson, John

    2016-01-01

    OBJECTIVE To describe the origin and development of the Division of Plastic and Reconstructive Surgery at the Queen’s University School of Medicine (Kingston, Ontario). METHODS Resarch ethics board approval and privacy agreements from the Kingston General Hospital (KGH, Kingston, Ontario) medical archives were obtained. Primary and secondary data sources were identified. A systematic examination of newspaper archives, research literature, KGH medical advisory committee meeting minutes, and testimonies from Dr Kenneth Wyllie and Dr John Davidson were obtained. RESULTS In 1949, Dr Albert Ross Tilley arrived at Queen’s University in Kingston, Ontario. There, Tilley initiated the Burn Unit at the KGH and began monthly teaching during the academic semester. Ken Wyllie (Meds ’55), Lloyd Carlson (Meds ’57) and John Emery (Meds ’57) were the notable progeny of his early initiatives. In 1963, Kenneth Wyllie founded the Division of Plastic and Reconstructive Surgery in Kingston, Ontario, having completed plastic surgery training in Toronto and Edinburgh with experiences in Stockholm (Sweden), Paris (France) and Baltimore (Maryland, USA). He was shortly joined by Pat Shoemaker (Meds ’66). John Davidson (Meds ’82) arrived in 1989, bringing an interest in microsurgery and critical inquiry to the division. Five notable surgeons, Cartotto (Meds ’88), Watkins, Watters, Meathrel (Meds ’03) and McKay, further enhanced the Division’s clinical and academic mission. CONCLUSIONS The collective activity of the Division of Plastic and Reconstructive Surgery at Queen’s School of Medicine in its 66-year history has encouraged more than 40 others to pursue distinguished careers in the specialty throughout North America, including three past presidents of the Canadian Society of Plastic Surgeons. PMID:28439504

  16. Radio Meteors Observations Techniques at RI NAO

    Science.gov (United States)

    Vovk, Vasyl; Kaliuzhnyi, Mykola

    2016-07-01

    The Solar system is inhabited with large number of celestial bodies. Some of them are well studied, such as planets and vast majority of big asteroids and comets. There is one group of objects which has received little attention. That is meteoroids with related to them meteors. Nowadays enough low-technology high-efficiency radio-technical solutions are appeared which allow to observe meteors daily. At RI NAO three methodologies for meteor observation are developed: single-station method using FM-receiver, correlation method using FM-receiver and Internet resources, and single-station method using low-cost SDR-receiver.

  17. Exploration of simultaneous polydrug use: risk and protective factors in undergraduate students in one university, Kingston - Jamaica

    Directory of Open Access Journals (Sweden)

    Carole Mitchell

    2012-01-01

    Full Text Available El policonsumo simultáneo de sustancias psicoactivas en estudiantes de una universidad fue estudiado en Kingston, Jamaica. El estudio fue de diseño transversal, y utilizó la modalidad de encueta para la recolección de datos. Examinamos factores de riesgo y de protección asociados al policonsumo simultáneo en una muestra de 295 estudiantes de pregrado de los departamentos de la salud y de la ciencia médica de la universidad participante. Nuestros resultados sugieren que la estancia continuada con la familia, el apoyo familiar, y el bienestar de los estudiantes son factores de riesgo. Por el contrario, la facilidad del acceso de las drogas y el apoyo emocional se podrían considerar como factores protectores. Estos hallazgos pueden informar programas preventivos, aunque se requiere investigación adicional.

  18. Absence of impact of aerial malathion treatment on Aedes aegypti during a dengue outbreak in Kingston, Jamaica

    Directory of Open Access Journals (Sweden)

    Trevor Castle

    1999-02-01

    Full Text Available During an outbreak of dengue fever in Jamaica from October to December 1995, a study was carried out to determine the impact of aerial ultra-low volume malathion treatment on adult Aedes aegypti. This was done by monitoring oviposition rates of the vector in three urban communities in Kingston and by exposing caged mosquitoes both directly and indirectly to the aerial malathion treatment. The insecticide was delivered at a rate of 219 mL/ha between 7:10 a.m. and 8:45 a.m. The results of the study clearly showed that the insecticide application was ineffective in interfering with Aedes aegypti oviposition, and adult mosquitoes held in cages inside dwellings were largely unaffected. Consequently, this type of intervention seemed to have little significant impact in arresting or abating dengue transmission.

  19. The Museum of Health Care at Kingston: its role in the preservation of the legacy of health care in Canada.

    Science.gov (United States)

    Low, James A

    2009-01-01

    Beginning in the 16th century, museums were an important resource for medical education. By the mid 20th century, however, the perceived educational value of museum collections declined and museums adopted the strategy of turning collections into publicly accessible medical history. The Museum of Health Care at Kingston, governed by a Board of Directors, began in 1991. The collection reflective of health care in Canada is available as a research resource through the Museum website and Artefacts Canada. The Museum communicates the history and science of health and health care as it has occurred in Canada to the general public by means of special events, exhibits and educational programs. The outstanding challenge for the Museum, as a not-for-profit institution, is to meet the increasing demands of the annual operating budget and to establish an Endowment Fund to assure long-term financial stability of the Museum.

  20. ri Talveti luulepiiriületamised / Jüri Talvet ; intervjueerinud Rein Veidemann

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    2010-01-01

    IX Moncayo luulefestivalist Aragoonias 10. aug. 2010 ja Jüri Talveti luule tõlgetest: Del sueno, de la nieve / tõlkinud Albert Lázaro Tinaut (Olifante, 2010) ; Of Snow, of Soul / tõlkinud H. L. Hix (Guernica, 2010)

  1. Earthquake forecast models for Italy based on the RI algorithm

    Directory of Open Access Journals (Sweden)

    Kazuyoshi Z. Nanjo

    2010-11-01

    Full Text Available This study provides an overview of relative-intensity (RI-based earthquake forecast models that have been submitted for the 5-year and 10-year testing classes and the 3-month class of the Italian experiment within the Collaboratory for the Study of Earthquake Predictability (CSEP. The RI algorithm starts as a binary forecast system based on the working assumption that future large earthquakes are considered likely to occur at sites of higher seismic activity in the past. The measure of RI is the simply counting of the number of past earthquakes, which is known as the RI of seismicity. To improve the RI forecast performance, we first expand the RI algorithm to become part of a general class of smoothed seismicity models. We then convert the RI representation from a binary system into a testable CSEP model that forecasts the numbers of earthquakes for the predefined magnitudes. Our parameter tuning for the CSEP models is based on the past seismicity. The final submission is a set of two numerical data files that were created by tuned 5-year and 10-year models and an executable computer code of a tuned 3-month model, to examine which testing class is more meaningful in terms of the RI hypothesis. The main purpose of our participation is to better understand the importance (or lack of importance of RI of seismicity for earthquake forecastability.

  2. 33 CFR 80.150 - Block Island, RI.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Block Island, RI. 80.150 Section... NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.150 Block Island, RI. The 72 COLREGS shall apply on the harbors of Block Island. ...

  3. RI-production plan using JMTR

    Energy Technology Data Exchange (ETDEWEB)

    Hori, Naohiko; Izumo, Hironobu; Kanno, Masaru; Nakagawa, Tetsuya; Kawamura, Hiroshi [Japan Atomic Energy Agency (JAEA), Ibaraki (Japan)

    2008-11-15

    At Oarai Research and Development Centre, Japan Atomic Energy Agency (JAEA) is advancing the plan of refurbishing Japan Materials Testing Reactor (JMTR) to start the operation from FY 2011. At the JMTR, the iridium-192 ({sup 192}Ir) source for the medical treatment as well as for the industrial using in the non-destructive inspection has been irradiated. As one of effective use of the renewed JMTR, JAEA has a plan to produce molybdenum-99 ({sup 99}Mo), a parent nuclide of technetium-99 ({sup 99m}Tc). {sup 99m}Tc is most commonly used as a radiopharmaceutical in the field of nuclear medicine. Furthermore, production of radioisotope (RI) for which increasing demand is expected, e.g. rhenium-188 ({sup 188}Re) which is being expected as a cancer treatment medicine.

  4. 76 FR 81999 - Submission for Review: Verification of Who Is Getting Payments, RI 38-107 and RI 38-147

    Science.gov (United States)

    2011-12-29

    ... MANAGEMENT Submission for Review: Verification of Who Is Getting Payments, RI 38-107 and RI 38-147 AGENCY: [email protected] or faxed to (202) 395-6974. SUPPLEMENTARY INFORMATION: RI 38-107, Verification of Who..., must verify that the entitled person is indeed receiving the monies payable. RI 38-147, Verification of...

  5. Spallation RI beam facility and heavy element nuclear chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Nagame, Yuichiro [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1997-11-01

    An outline of the spallation RI (Radioactive Ion) beam facility is presented. Neutron-rich nuclides are produced in the reaction of high intensity (10-1000 {mu}A) protons with energy of 1.5 GeV and an uranium carbide target. Produced nuclides are ionized in an isotope separator on-line (ISOL) and accelerated by the JAERI tandem and the booster linac. Current progress and a future project on the development of the RI beam facility are given. Studies of transactinide elements, including the synthesis of superheavy elements, nuclear structure far from stability, and RI-probed material science are planned with RI beams. An outlook of the transactinide nuclear chemistry studies using neutron-rich RI beams is described. (author)

  6. Interlaboratory Comparison for Digestion Methods, Analytical Methods, and Holding Times for the Analysis of Trace Elements in Biological Samples for the Kingston Fly Ash Recovery Project

    Energy Technology Data Exchange (ETDEWEB)

    Mathews, Teresa J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Rogers, William J [Tennessee Valley Authority (TVA), Knoxville, TN (United States); Vitale, Rock [Environmental Standards, Inc., Knoxville, TN (United States); Smith, John G. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Brandt, Craig C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Peterson, Mark J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Carriker, Neil [Tennessee Valley Authority (TVA), Knoxville, TN (United States)

    2013-05-01

    In December 2008, an ash dike at the Tennessee Valley Authority (TVA) Kingston Fossil Plant (KIF) ruptured, releasing over 1 billion gallons of coal ash into the Emory and Clinch Rivers. Coal ash may contain several contaminants of concern; of these, selenium (Se), arsenic (As), and mercury (Hg) have been highlighted in this work because of their toxicity and potential to bioaccumulate in aquatic food chains (Reash et al. 2006, Chapman et al. 2010). To assess the potential impact of the spilled coal ash on humans and the environment, a comprehensive monitoring program was established at the Kingston site, for which resident aquatic organisms (among other sample media) are collected to determine contaminant exposure and evaluate the risk to humans and wildlife.

  7. Näitus "Sajand eesti puugravüüri klotsidel" / Jüri Hain

    Index Scriptorium Estoniae

    Hain, Jüri, 1941-

    2007-01-01

    Eesti Rahvusraamatukogus 15. I-3. II eksponeeritud ja rahvusraamatukogu kollektsioonist koostatud näitusest "Sajand eesti puugravüüri klotsidel: 1840-1940". Järgmistest kunstnikest ja nende töödest: Aleksander Otto Gern, Bogdan Gottlieb Friedrich Kally, August Daugell, Hermann Eduard Hartmann, Eduard Magnus Jakobson, Mart Pukits, Andres Kuusk, Karl Friedrich Schnell, Anton Suurkask (1873-1965), Arkadio Laigo, Hando Mugasto, Eduard Järv, Richard Kaljo, Ott Kangilaski, Ants Puks (1918-?), Salome Trei

  8. Üksikud naljakad peaaegu kolmikud / Jüri Viikberg ; tlk. Jüri Viikberg

    Index Scriptorium Estoniae

    Viikberg, Jüri 1953-

    2005-01-01

    Arvustus: Punttila, Matti. Haaskannäköinen tyttö : kielikaskuista sanaleikkeihin. Helsinki, 1998 ; Punttila, Matti. Pilkettä silmäkulmaan : kielikaskuista sanaleikkeihin. Helsinki, 2001 ; Punttila, Matti. Poskettomia huulia : kielikaskuista sanaleikkeihin. Helsinki, 2004. Näiteid: Kui keel ei püsi hammaste taga ; Sõna keeles ja keel hammaste vahel / tõlkinud Jüri Viikberg // Oma Keel, 1995, nr. 1, lk. 55-56, 63-64

  9. Hydrogeology and Simulation of Groundwater Flow in the Plymouth-Carver-Kingston-Duxbury Aquifer System, Southeastern Massachusetts

    Science.gov (United States)

    Masterson, John P.; Carlson, Carl S.; Walter, Donald A.; Other contributing authors: Bent, Gardner C.; Massey, Andrew J.

    2009-01-01

    The glacial sediments that underlie the Plymouth-Carver-Kingston-Duxbury area of southeastern Massachusetts compose an important aquifer system that is the primary source of water for a region undergoing rapid development. Population increases and land-use changes in this area has led to two primary environmental effects that relate directly to groundwater resources: (1) increases in pumping that can adversely affect environmentally sensitive groundwater-fed surface waters, such as ponds, streams, and wetlands; and (2) adverse effects of land use on the quality of water in the aquifer. In response to these concerns, the U.S. Geological Survey, in cooperation with the Massachusetts Department of Environmental Protection, began an investigation in 2005 to improve the understanding of the hydrogeology in the area and to assess the effects of changing pumping and recharge conditions on groundwater flow in the Plymouth-Carver-Kingston-Duxbury aquifer system. A numerical flow model was developed based on the USGS computer program MODFLOW-2000 to assist in the analysis of groundwater flow. Model simulations were used to determine water budgets, flow directions, and the sources of water to pumping wells, ponds, streams, and coastal areas. Model-calculated water budgets indicate that approximately 298 million gallons per day (Mgal/d) of water recharges the Plymouth-Carver-Kingston-Duxbury aquifer system. Most of this water (about 70 percent) moves through the aquifer, discharges to streams, and then reaches the coast as surface-water discharge. Of the remaining 30 percent of flow, about 25 percent of the water that enters the aquifer as recharge discharges directly to coastal areas and 5 percent discharges to pumping wells. Groundwater withdrawals are anticipated to increase from the current (2005) rate of about 14 Mgal/d to about 21 Mgal/d by 2030. Pumping from large-capacity production wells decreases water levels and increases the potential for effects on surface

  10. Characterization of Three New Glutaredoxin Genes in the Arbuscular Mycorrhizal Fungus Rhizophagus irregularis: Putative Role of RiGRX4 and RiGRX5 in Iron Homeostasis

    Science.gov (United States)

    Tamayo, Elisabeth; Benabdellah, Karim; Ferrol, Nuria

    2016-01-01

    Glutaredoxins (GRXs) are small ubiquitous oxidoreductases involved in the regulation of the redox state in living cells. In an attempt to identify the full complement of GRXs in the arbuscular mycorrhizal (AM) fungus Rhizophagus irregularis, three additional GRX homologs, besides the formerly characterized GintGRX1 (renamed here as RiGRX1), were identified. The three new GRXs (RiGRX4, RiGRX5 and RiGRX6) contain the CXXS domain of monothiol GRXs, but whereas RiGRX4 and RiGRX5 belong to class II GRXs, RiGRX6 belongs to class I together with RiGRX1. By using a yeast expression system, we observed that the newly identified homologs partially reverted sensitivity of the GRX deletion yeast strains to external oxidants. Furthermore, our results indicated that RiGRX4 and RiGRX5 play a role in iron homeostasis in yeast. Gene expression analyses revealed that RiGRX1 and RiGRX6 were more highly expressed in the intraradical (IRM) than in the extraradical mycelium (ERM). Exposure of the ERM to hydrogen peroxide induced up-regulation of RiGRX1, RiGRX4 and RiGRX5 gene expression. RiGRX4 expression was also up-regulated in the ERM when the fungus was grown in media supplemented with a high iron concentration. These data indicate the two monothiol class II GRXs, RiGRX4 and RiGRX5, might be involved in oxidative stress protection and in the regulation of fungal iron homeostasis. Increased expression of RiGRX1 and RiGRX6 in the IRM suggests that these GRXs should play a key role in oxidative stress protection of R. irregularis during its in planta phase. PMID:26900849

  11. Assessing the phytoplankton and water quality of Kingston Harbour and Hellshire coast, Jamaica, after the implementation of a waste water treatment facility

    Directory of Open Access Journals (Sweden)

    Helen A. Liu

    2014-09-01

    Full Text Available Deteriorating water quality of Kingston Harbour, due primarily to sewage discharge and its effect on nearby Hellshire Coast, has been an issue since the 1970s. The implementation of a new sewage treatment facility in 2007 to receive the harbour’s waste at Soapberry was expected to make a positive difference. Physico-chemical and biological parameters were used to assess water quality to determine the effect of the facility. Eleven stations used in earlier studies (1990 to 1998 were re-sampled to represent Kingston, Hunts Bay and North East Hellshire coastline over a four week sampling regime between May and June 2011. While temperature, salinity, turbidity, dissolved oxygen and pH remained unchanged between the 1990’s and 2011, BOD5, faecal coliform and nitrate concentrations indicated that the water quality had improved minimally in Kinsgton and Hellshire,and deteriorated significantly in Hunts. Phytoplankton biomass decreased in Kingston (from 3.84 mg m-3 in 1998 to 2.81 mg m-3 in 2011 and increased significantly in Hunts (from 14.69 mg m-3 in 1998 to 24.17 mg m-3 in 2011. Biomass along Hellshire was similar (2.15 mg m-3 in 1998; 2.45 mg m-3 in 2011. In 1998 the nanoplankton biomass (2.7 to 20μm dominated throughout the Harbour. In 2011 Hunts Bay was dominated by net-plankton (>20μm, indicative of eutrophic waters.

  12. Caregiver knowledge, attitudes, and practices regarding childhood diarrhea and dehydration in Kingston, Jamaica Conocimientos, actitudes y prácticas de los cuidadores hacia la diarrea infantil y la deshidratación en Kingston, Jamaica

    Directory of Open Access Journals (Sweden)

    Lela Rose Bachrach

    2002-07-01

    Full Text Available Objective. To study the knowledge, attitudes, and practices of caregivers in Kingston, Jamaica, regarding childhood diarrhea and dehydration in order to determine if limited caregiver knowledge about the prevention and treatment of diarrhea and dehydration puts children at increased risk of presenting at the hospital for these concerns. Methods. The study was an observational case-control study conducted between February 1997 and May 1997 at Bustamante Hospital for Children in Kingston. Convenience sampling was used and data were collected by face-to-face interviews with two groups of caregivers of children under 5 years of age. One group (n = 117 presented with children with acute gastroenteritis, and the other group (n = 98 presented with acute concerns unrelated to gastroenteritis. While 197 of the 215 caregivers interviewed were the mother of a child, there were also 9 guardians, 5 fathers, and 4 grandmothers in the sample. Results. The mean caregiver age, level of education, and socioeconomic status were similar for the two groups. The caregivers in the gastroenteritis group were more likely to present with younger children and to have less convenient access to running water or a refrigerator. Children of caregivers who had never heard of oral rehydration therapy were at increased risk of presenting with gastroenteritis and dehydration (odds ratio [OR], 4.6; 95% confidence interval [CI], 1.8-11.7, as were children of caregivers with low knowledge scores about the prevention and treatment of diarrhea and dehydration (OR, 3.7; 95% CI, 1.6-8.8. Another independent risk factor was a caregiver's poor sense of self-reliance in managing a child's diarrhea (OR, 2.3; 95% CI, 1.1-4.9. Conclusions. These findings highlight a need to enhance educational efforts that will empower caregivers to protect their children from diarrhea-associated morbidity and mortality.Objetivos. Estudiar los conocimientos, actitudes y prácticas de los cuidadores hacia la

  13. The prevalence and associated demographic factors of dementia from a cross-sectional community survey in Kingston, Jamaica.

    Science.gov (United States)

    Neita, Susanne M; Abel, Wendel D; Eldemire-Shearer, Denise; James, Kenneth; Gibson, Roger C

    2014-01-01

    Using a cross-sectional community survey, the authors aimed to estimate the prevalence of dementia among a sample of older Jamaicans and to identify associated demographic factors. From February to July 2010, persons of age ≥60 years were randomly selected from two communities in Kingston, Jamaica and screened with the Mini Mental Status Examination (MMSE). All MMSE-positive participants and an equal number of matched MMSE-negative participants underwent definitive diagnostic evaluation for dementia using the Clinical and Diagnostic Assessment Procedure for Dementia. Subsequently derived MMSE sensitivity and specificity measures from the subsample were used to estimate the overall prevalence of dementia (primary outcome). Chi square, Fisher's Exact, Exact, Spearman's correlation and t-tests were used to explore associations of dementia with age, gender, educational level and socioeconomic status. Statistical significance was taken as p < 0.05. Two hundred participants were recruited. Age-standardized prevalence rates of dementia were 5.07% (standardized to the Jamaican population) and 5.32% (standardized to the West Europe population). Dementia was more prevalent among older persons (Spearman's rho = 0.31; p < 0.001); no other significant associations were found. Dementia prevalence found in this study is lower than figures from previous Caribbean reports. The older persons are disproportionately affected. Copyright © 2013 John Wiley & Sons, Ltd.

  14. The benefits of phone support and home visits: an evaluation of the City of Kingston's Breastfeeding Support Service.

    Science.gov (United States)

    Coffield, Karen

    2008-11-01

    This paper presents an evaluation of the City of Kingston Breastfeeding Support Service that was performed in 2006. The evaluation utilised a mail-out questionnaire designed to investigate mothers' breastfeeding expectations, experiences, issues and support received, in addition to their experience of using the Service. Seventy-seven percent of mothers contacted the service for support due primarily to problems with positioning and attachment, nipple pain or mastitis. Other reasons were also cited, reflecting that it takes time and experience for women to learn to breastfeed and to develop an understanding of their lactation. The study found that on discharge from the hospital, 59% of mothers were fully breastfeeding; this figure decreased to 32% at the time of contacting the service, but increased to 42% two weeks after contacting the service. Satisfaction with both the model of service and the support received was very high. Mothers were able to feel more comfortable with their breastfeeding (75%), to breastfeed for longer (59%) and with more confidence (71%) and greater knowledge (68%) about breastfeeding and lactation. The majority of mothers (96%) reported they would contact the service again if they needed further breastfeeding advice and support.

  15. Impact Through Outreach and Education with Europlanet 2020-RI

    Science.gov (United States)

    Heward, A.; Barrosa, M.; NA 2 Europlanet 2020 RI Outreach Team

    2017-09-01

    The Europlanet 2020 Research Infrastructure (RI), funded through the EC's Horizon 2020 programme, was launched in 2015 to support Europe's planetary science community and provide services, access to facilities, new research tools and a virtual planetary observatory. The exploration of our Solar System has long been recognised as a potential 'hook' for attracting people with many diverse backgrounds and interests into science. Europlanet 2020 RI's Impact Through Outreach and Education (IOE) activities aim to engage the widest possible community with the work of Europlanet 2020 RI, and to involve the public, the media, policy makers, educators and students with the ongoing adventure of planetary science and the people that work in the field.

  16. [Mihai Eminescu luulefestivalil osales Jüri Talvet

    Index Scriptorium Estoniae

    2014-01-01

    Mihai Eminescu luulefestivalil esitleti mahukat tõlkeantoloogiat "Antologia poeziei universal de astăzi" (Craiova: Editura Europa”, 2014), mille on koostanud Ion Deaconescu. Antoloogias on ka Jüri Talveti luulet

  17. Ühest avastamata illustreeritud raamatust / Jüri Hain

    Index Scriptorium Estoniae

    Hain, Jüri, 1941-

    2011-01-01

    Erick, Françoise. Heute / ill. Sergei Slastnikov. Tallinn : Tallinna Eesti Kirjastus-Ühisus, 1926. S. Slastnikovi puugravüüris illustratsioonidest, tema kunstialastest kirjutistest ja puugravüüri kasutuselevõtust eesti raamatukunstis

  18. Literature as a nation's emotional memory / Jüri Talvet

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    1998-01-01

    Bibliograafia, lk. 134-135. Autorist lk. 387. Juri Lotmani semiosfääri tõlgendamisest: "süntagmaatilised" struktuurid ja "perifeersed" kultuurid. Ka Friedebert Tuglase "Kalevipoja"-kriitikast ning Lydia Koidula ja Juhan Liivi luuletustest

  19. President vabastas Jüri Sakkarti kohtuniku ametist / Tanel Mazur

    Index Scriptorium Estoniae

    Mazur, Tanel, 1971-

    2010-01-01

    President Toomas Hendrik Ilves kirjutas 9. veebruaril 2010 alla otsusele vabastada Jüri Sakkart Viru Maakohtu kohtuniku ametist tema enda soovil. Kaitsepolitsei on J. Sakkarti kuriteokahtlustusega kinni pidanud

  20. Eestlased ARS BALTICA 08-l Austrias / Jüri Hain

    Index Scriptorium Estoniae

    Hain, Jüri, 1941-

    2008-01-01

    Rahvusvaheline kunstinäitus "ARS BALTICA 08" Salzburgi näitusehoones Berchtoldvilla, kuraator Peter Rieder. Osalesid kunstnikud Eestist (Mare Vint, Marje Üksine, Andres Tolts, Tiiu Kirsipuu, Jüri Hain), Lätist, Leedust ja Soomest

  1. Helilooja Jüri Dmitrievi loominguline õhtu / Vladislav Horuzhenko

    Index Scriptorium Estoniae

    Horuzhenko, Vladislav

    2006-01-01

    Viiuldajast, pianistist ja heliloojast Jüri Dmitrievist. Loomingulisest õhtust 8. okt. Pärnu raekojas Pärnumaa Rahvakultuuri Keskseltsi korraldatava projekti "Inimesed Pärnumaa kultuurimaastikul" raames

  2. Eurosib tuleb Eestisse laia teenustehulgaga / Jüri Ader

    Index Scriptorium Estoniae

    Ader, Jüri

    2005-01-01

    Venemaa viie juhtiva logistikafirma hulka kuuluva Eurosib SPb-TS-i Tallinna esinduse juhataja Jüri Ader vahendab peakorteri vastuseid küsimustele, mis puudutavad Eurosibi plaane ja teenuseid Eestis. Lisa: Eurosib leiab rakenduse 9000 raudteevagunile

  3. Pealinlased olid aktiivsemad valijad / Jüri Ratas

    Index Scriptorium Estoniae

    Ratas, Jüri, 1978-

    2007-01-01

    Ilmunud ka: Stolitsa, 14. märts 2007, lk. 2. Tallinna linnapea Jüri Ratas parlamendivalimiste tulemustest. Vt. samas: Kes Tallinnast riigikokku valiti?; Riigikogu valimise tulemused Tallinnas: diagramm

  4. Szathmári, a great documentary artist

    Directory of Open Access Journals (Sweden)

    Ionescu, Adrian-Silvan

    2014-01-01

    Full Text Available Carol Pop de Szathmári was born in Cluj, Transylvania, on 11 January 1812. His talent for painting shone out from an early age. Being a passionate traveller, Szathmári journeyed through Europe and often crossed the Carpathian Mountains to visit Wallachia and its capital, Bucharest, where he eventually settled in 1843. An accomplished landscape and portrait painter, at ease with both watercolours and oil paints, Szathmári obtained commissions from the wealthy Wallachian boyars. Szathmári kept up constant, good relations with the successive ruling princes of Wallachia for whom he painted portraits and various other compositions. By 1848, Szathmári began to experiment with photography. The outbreak of the Russian-Ottoman War in late June 1853 saw the Romanian principalities occupied by the Russian army. In April 1854, Szathmári filled a van with his cameras and glass plates and went to the Danube to document the fighting between the Russian and Turkish armies.The result of Szathmári's bravery and hard work was a photographic album. His album, containing some two hundred images, became famous due to its presentation at the 1855 Paris World's Fair and Szathmári was awarded the Second Class Medal for his work.From that time on, photography, painting and lithography were always closely connected in Szathmári's career. In 1864 he became a member of the Société Française de Photographie in Paris and in 1870 of the one in Vienna. In 1863, he was appointed Court Painter and Photographer, a position he held for the rest of his life. In that capacity, he followed his patron, Prince Carol I, on the battlefield during the Russian-Romanian-Ottoman War of 1877, which was waged south of the Danube. Alongside martial compositions and albums, Szathmári had long been attracted by folk types and produced a large series of pictures of peasants, gypsies, postillions, merchants and artisans. He toured the fairs and the crowded streets of the town in search

  5. Püha Jüri : raha- ja jumalateenija / Kadri Jakobson

    Index Scriptorium Estoniae

    Jakobson, Kadri, 1970-

    2007-01-01

    Maalehe nõukogu esimehel Jüri Ehasalul on osalus mitmetes äriühingutes, samuti on ta Toomkoguduse juhatuse aseesimees ja ajalehe Eesti Kirik nõukogu esimees. Vt. samas: Eesti Post - kannatuste jada. Lisa: Jüri Ehasalu. Kommenteerivad: Silja Lättemäe, Jüri Käsper, Toomas, Leito

  6. ri Lina kui tegelikkusele osutav Patagoonia šamaan / Jüri Lina ; intervjueerinud Ingrid Peek

    Index Scriptorium Estoniae

    Lina, Jüri, 1949-

    2011-01-01

    2.-5. juunini Tallinnas kinos Sõprus toimuva festivali "Hallo, Kosmos!" raames 2. juunil esilinastuvast Jüri Lina filmist "Täitmatu Uroboros. Massoonide salakaval taktika", tema uuringute põhjusest. Festivali "Hallo, Kosmos!" kavast

  7. Parent and caregiver knowledge, beliefs, and responses to convulsive seizures in children in Kingston, Jamaica - A hospital-based survey.

    Science.gov (United States)

    Hall-Parkinson, Debra; Tapper, Judy; Melbourne-Chambers, Roxanne

    2015-10-01

    The objective of this study was to determine the knowledge and beliefs about seizures and actions during seizures of parents/caregivers of Jamaican children hospitalized for convulsive seizures. This was a cross-sectional study of parents and caregivers of children with acute convulsive seizures hospitalized at the Bustamante Hospital, Kingston, Jamaica between May 1 and October 31, 2013. Subjects were identified by admission records. Parents/caregivers were invited to participate. A questionnaire on the demographics, knowledge, beliefs, and response of parents/caregivers during the child's current seizure episode was administered face to face. Data were analyzed for frequencies: groups were compared using chi-square analysis for categorical variables, Student's t-test for normally distributed data, and the Mann-Whitney U-test for data not normally distributed. There were fifty participants: 39 (78%) mothers, mean (SD) age - 33.8 (10.1) years. All sought medical care first. Twenty-two (44%) had plausible beliefs about the cause of seizures. Twenty-seven (54%) knew of appropriate actions during a seizure, 10 (20%) knew of appropriate precautions, and 11 (22%) responded appropriately during the seizure. Eleven (22%) reported receiving seizure education. Witnessing a previous seizure, education level, and seizure education were associated with knowledge of seizures (p<0.05). Socioeconomic status was higher in those with plausible beliefs about seizures and lower in those who took appropriate action during a seizure (p<0.05). Parents/caregivers of children with convulsive seizures have appropriate health-care seeking behavior, but most do not have appropriate knowledge about seizures. Few take appropriate action during the episode. A public education program is needed to improve parental knowledge of and response to convulsive seizures. Copyright © 2015 Elsevier Inc. All rights reserved.

  8. The incidence of emergence delirium and risk factors following sevoflurane use in pediatric patients for day case surgery, Kingston, Jamaica

    Directory of Open Access Journals (Sweden)

    Rachel Gooden

    2014-12-01

    Full Text Available Background and objectives: Emergence delirium is a distressing complication of the use of sevoflurane for general anesthesia. This study sought to determine the incidence of emergence delirium and risk factors in patients at a specialist pediatric hospital in Kingston, Jamaica. Methods: This was a cross-sectional, observational study including pediatric patients aged 3-10 years, ASA I and II, undergoing general anesthesia with sevoflurane for elective day-case procedures. Data collected included patients' level of anxiety pre-operatively using the modified Yale Preoperative Anxiety Scale, surgery performed, anesthetic duration and analgesics administered. Postoperatively, patients were assessed for emergence delirium, defined as agitation with non-purposeful movement, restlessness or thrashing; inconsolability and unresponsiveness to nursing and/or parental presence. The need for pharmacological treatment and post-operative complications related to emergence delirium episodes were also noted. Results: One hundred and forty-five (145 children were included, with emergence delirium occurring in 28 (19.3%. Emergence delirium episodes had a mean duration of 6.9±7.8 min, required pharmacologic intervention in 19 (67.8% children and were associated with a prolonged recovery time (49.4±11.9 versus 29.7± 10.8 min for non-agitated children; p<0.001. Factors positively associated with emergence delirium included younger age (p = 0.01, OR 3.3, 95% CI 1.2-8.6 and moderate and severe anxiety prior to induction (p <0.001, OR 5.6, 95% CI 2.3-13.0. Complications of emergence delirium included intravenous line removal (n = 1, and surgical site bleeding (n = 3. Conclusion: Children of younger age with greater preoperative anxiety are at increased risk of developing emergence delirium following general anesthesia with sevoflurane. The overall incidence of emergence delirium was 19%.

  9. FcR gamma-chain dependent signaling in immature Neutrophils is mediated by Fc alpha RI, but not by Fc gamma RI

    NARCIS (Netherlands)

    Otten, Marielle A.; Leusen, Jeanette H. W.; Rudolph, Esther; van der Linden, Joke A.; Beelen, Robert H. J.; de Winkel, Jan G. J. van; van Egmond, Marjolein

    2007-01-01

    Neutrophil-mediated tumor cell lysis is more efficiently triggered by Fc alpha RI (CD89), than by Fc gamma RI (CD64). This difference is most evident in immature neutrophils in which Fc gamma RI-mediated tumor cell lysis is absent. In this study, we show that FcR gamma-chain-dependent functions

  10. Riigi äriühingu juhtorgani liige: kas ametiisik või ärijuht? / Jüri Raidla, Toomas Vaher, Kristel Urke

    Index Scriptorium Estoniae

    Raidla, Jüri, 1957-

    2017-01-01

    Riigi äriühingu põhijoontest, riigi äriühingu juhtorgani liikme kohustustest ja nõuetest juhtorgani liikmetele. Riigi äriühingute juhtorganite liikmete pidamisest ametiisikuteks korruptsioonivastase seaduse § 2 lõike 1 ja karistusseadustiku § 288 lõike 1 mõttes. Sisaldab asjakohast kohtupraktikat

  11. Schedule Optimization Study, Hanford RI/FS Program

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-01

    A Schedule Optimization Study (SOS) of the US Department of Energy (DOE) Hanford Site Remedial Investigation/Feasibility Study (RI/FS) Program was conducted by an independent team of professionals from other federal agencies and the private sector experienced in environmental restoration. This team spent two weeks at Hanford in September 1992 examining the reasons for the lengthy RI/FS process at Hanford and developing recommendations to expedite the process. The need for the study arose out of a schedule dispute regarding the submission of the 1100-EM-1 Operable Unit RI/FS Work Plan. This report documents the study called for in the August 29, 1991, Dispute Resolution Committee Decision Statement. Battelle's Environmental Management Operations (EMO) coordinated the effort for DOE's Richland Field Office (RL).

  12. Midwives' knowledge and attitudes when encountering Gender-Based Violence in their practice at a maternity-hospital in Kingston, Jamaica.

    Science.gov (United States)

    Pitter, Cynthia Pearl

    2016-01-01

    Gender-based violence (GBV) can have devastating consequences for pregnancy because both mother and child are at risk. Midwives are in a strategic position to identify and empower pregnant women experiencing GBV; however, currently midwives in Jamaica are not required to screen for GBV, neither are they prepared to do so. This study forms the baseline of a larger study designed to improve the capacity of midwives to identify and treat pregnant women experiencing GBV in Jamaica. This specific component assessed midwives' knowledge and attitudes when encountering GBV in their practice in Kingston, Jamaica. A qualitative study design was used. Six practicing midwives were purposely selected to participate in a focus group discussion at the antenatal clinic of a hospital in Kingston, Jamaica. All six respondents said it was very important to screen for GBV among pregnant women in their care. The findings from their report revolved around six themes, namely midwives have suboptimal knowledge, are exposed to women experiencing GBV in pregnancy, lack professional preparedness, report gaps in the institutional framework to guide their practice, are concerned for their safety and security, and are willing to intervene. This study confirmed that midwives are aware of the problem and are willing to intervene but are faced with lack of formal procedures to detect and treat pregnant women who are experiencing GBV. Findings could be used to inform a protocol which is being developed to guide midwives' practice. Findings could also be incorporated in the national strategy to eliminate GBV.

  13. 76 FR 18811 - Submission for Review: Letter Reply To Request for Information (RI 20-64), Former Spouse Survivor...

    Science.gov (United States)

    2011-04-05

    ... MANAGEMENT Submission for Review: Letter Reply To Request for Information (RI 20-64), Former Spouse Survivor Annuity Election (RI 20-64A), Information on Electing a Survivor Annuity for Your Former Spouse (RI 20-64B... Reply to Request for Information, RI 20-64, and Former Spouse Survivor Annuity Election, RI 20-64A. As...

  14. Global Ear Kingston

    OpenAIRE

    Henriques, Julian F.

    2012-01-01

    "The spirit of music feeds the soul. You can distract the people for a while, but wheh they are filled with the gimmick, they go back to what's real," says schoolteacher Michael 'Ibo' Cooper, formerly the keyboard player of Third World...

  15. Eduard Vääri : [Wiedemanni keeleauhinna laureaat 2001

    Index Scriptorium Estoniae

    2005-01-01

    Sisu: Kogu elu eesti keele kaitsel : [F. J. Wiedemanni keeleauhinna vastuvõtmisel peetud kõne alusel] ; Laks, Meinhard. Liivi rannarahva lipp : [luuletus] = Livõ rńdarouv plaga / liivi keelde tõlkinud Eduard Vääri

  16. ri Reinvere "Reekviemi" Saksamaa esiettekanne / foto: Aaron Nace

    Index Scriptorium Estoniae

    2009-01-01

    modernne ja müstiline helitöö, kirjutatud sooloflöödile, episoodilisele neljale meeshäälele ja loetud tekstile, koos spetsiaalselt teose jaoks austraalia filmirežissööri Catherine Jarvis'e tehtud filmiga on pilk eestlaste ning eestluse minevikku, teose esmaettekanne toimus 23. märtsil 2009 Helsingis

  17. Võrguäri Eestis kiratseb / Indrek Kald

    Index Scriptorium Estoniae

    Kald, Indrek, 1974-

    2004-01-01

    Autor otsib põhjusi, miks tänavuse Interneti-kaupluste edetabeli koostamiseks saatis oma äritulemused vaid viis võrgukauplust. Zebra Infosüsteemide tegevjuhi Peeter Tamme arvamus e-äri kiratsemise põhjuste kohta

  18. Tartu kui märk / Jüri Talvet

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    1996-01-01

    Ilmus algkujul hispaania keeles Sevillas Andaluusia Semiootikaassotsiatsiooni ajakirja Discurso Tartu semiootikakoolkonnale pühendatud erinumbris (nr. 8, 1993). Ilmunud ka kogumikus: Talvet, Jüri. Ameerika märkmeid, ehk, Kaemusi Eestist. Tartu : Ilmamaa, 2000, lk. 62-71, pealk.: Tartu vaim

  19. Kalevipoeg kui Eesti lunastaja / Jüri Talvet

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    2003-01-01

    Ka rahvusvahelisest projektist "Cultos", milles osalenud Tartu Ülikooli kirjanduse ja rahvaluule osakonna töörühm (Marin Laak, Piret Viires) võttis audiovisuaalse arvutiprogrammi aluseks Fr. R. Kreutzwaldi "Kalevipoja". Ilmunud ka kogumikus: Talvet, Jüri. Tõrjumatu äär. Tartu : Ilmamaa, 2005, lk. 404-407

  20. Sonya Smith ja telenovela-äri / Tiina Lepiste

    Index Scriptorium Estoniae

    Lepiste, Tiina

    2006-01-01

    Telenovelade ärist ja fenomenist. Ka Venetsueela päritolu näitlejannast Sonya Smithist seriaalis "Armastuse jõud". Sama: Teleleht, 17. Jul. 2006, nr. 28, lk. 6-7 : ill pealkirjaga "Seebiäri vohab ja õitseb"

  1. Hispaania kirjanduse elav keha / Jüri Talvet

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    1996-01-01

    Keha ja kehatus hispaania kirjanduses (Cervantese Dulcinea, Sancho Panza, don Quijote) ja maailmakirjanduses esinevate tegelaskujude näiteil : Ka Tõnu Õnnepalu Joonatanist romaanis 'Hind'. Ilmunud ka kogumikus: Talvet, Jüri. Tõrjumatu äär. Tartu : Ilmamaa, 2005, lk. 469-473

  2. 75 FR 17178 - Rhode Island Disaster #RI-00006

    Science.gov (United States)

    2010-04-05

    ... From the Federal Register Online via the Government Publishing Office ] SMALL BUSINESS ADMINISTRATION Rhode Island Disaster RI-00006 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for the State of Rhode Island...

  3. 77 FR 70203 - Rhode Island Disaster #RI-00010

    Science.gov (United States)

    2012-11-23

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Rhode Island Disaster RI-00010 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for the State of Rhode Island...

  4. 75 FR 22872 - Rhode Island Disaster Number RI-00006

    Science.gov (United States)

    2010-04-30

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Rhode Island Disaster Number RI-00006 AGENCY: U.S. Small Business Administration. ACTION: Amendment 2. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State...

  5. 75 FR 19666 - Rhode Island Disaster #RI-00007

    Science.gov (United States)

    2010-04-15

    ... [Federal Register Volume 75, Number 72 (Thursday, April 15, 2010)] [Notices] [Pages 19666-19667] [FR Doc No: 2010-8615] SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12116 and 12117] Rhode Island Disaster RI-00007 AGENCY: Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice...

  6. 77 FR 69915 - Rhode Island Disaster Number RI-00011

    Science.gov (United States)

    2012-11-21

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Rhode Island Disaster Number RI-00011 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public...

  7. 75 FR 18554 - Rhode Island Disaster Number RI-00006

    Science.gov (United States)

    2010-04-12

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Rhode Island Disaster Number RI-00006 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State...

  8. 78 FR 21492 - Rhode Island Disaster #RI-00012

    Science.gov (United States)

    2013-04-10

    ... From the Federal Register Online via the Government Publishing Office ] SMALL BUSINESS ADMINISTRATION Rhode Island Disaster RI-00012 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the...

  9. 75 FR 22873 - Rhode Island Disaster Number RI-00007

    Science.gov (United States)

    2010-04-30

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Rhode Island Disaster Number RI-00007 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public...

  10. 77 FR 67857 - Rhode Island Disaster #RI-00011

    Science.gov (United States)

    2012-11-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Rhode Island Disaster RI-00011 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the...

  11. 78 FR 4967 - Rhode Island Disaster #RI-00010

    Science.gov (United States)

    2013-01-23

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Rhode Island Disaster RI-00010 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Rhode...

  12. 76 FR 61131 - Rhode Island Disaster #RI-00008

    Science.gov (United States)

    2011-10-03

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Rhode Island Disaster RI-00008 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the State of Rhode Island dated 09...

  13. Äri domeeninimedega kogub Ameerikas hoogu / Margus Mihkels

    Index Scriptorium Estoniae

    Mihkels, Margus

    2006-01-01

    2005. aastal müüdi Ameerikas 5851 domeeninime ja nimeäri käive ulatus 29 miljoni USA dollarini. 2006. aasta esimese kolme kuu jooksul on ajakirja Domain Name Journal andmetel müüdud 1949 veebiaadressi 14,2 miljoni dollari eest

  14. Rahvus, "glokaalsus" ja eesti kirjandusdiskursus aastatuhandevahetusel / Jüri Talvet

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    2001-01-01

    Bibliogr. joonealustes märkustes. Artikli aluseks on rahvusvahelisel konverentsil "Cultural Identity and Its Glocal Manifestations" (Joensuu, 14.-16. IX 2000) peetud ingliskeelne ettekanne. Artikkel on ilmunud ka kogumikus: Talvet, Jüri. Tõrjumatu äär. Tartu : Ilmamaa, 2005, lk. 31-45

  15. Arved Viirlaid teises kaanonis / Jüri Talvet

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    2002-01-01

    Arved Viirlaid 80. Ka tema juubeliks ilmunud ingliskeelsest luulekogust "Selected poems" (tlk. Taimi Ene Moks ja R. W. Stedingh). Ilmunud ka kogumikus: Talvet, Jüri. Tõrjumatu äär. Tartu : Ilmamaa, 2005, lk. 417-420, pealk.: Teises Kaanonis: Viirlaiu luule inglise keeles

  16. Mida me Tallinnas teinud oleme / Jüri Ratas

    Index Scriptorium Estoniae

    Ratas, Jüri, 1978-

    2006-01-01

    Tallinna linnapea Jüri Ratas annab ülevaate linnavalitsuse tegevusest esimese saja päeva jooksul. Linnavalitsuse tegevust hindavad Tallinna volikogu Isamaaliidu fraktsiooni esimees Toomas Tõniste, volikogu Reformierakonna esimees Keit Pentus ja volikogu sotsiaaldemokraatide fraktsiooni aseesimees Hannes Rumm

  17. Maurice Riès et ses fils

    Directory of Open Access Journals (Sweden)

    Lukian Prijac

    2004-12-01

    Full Text Available Maurice Riès [1858-1945], originaire de Marseille, arrive à Aden en 1876 comme employé de César Tian. Très vite, il s'impose dans l'entreprise et devient l'associé de son patron en 1891. M. Riès est le dernier associé d'Arthur Rimbaud, et est avant-tout un négociant spécialiste du commerce yéménite et plus particulièrement du café qu'il exporte en Europe. Mais c'est aussi un diplomate et dès 1897, il devient l'agent consulaire de France à Aden. Cette gérance, il l'effectue en collaboration avec ses fils Paul et Adolphe Riès jusqu'en 1920. Les Riès par leurs actions commerciales et diplomatiques surent contribuer au renom de la France au Yémen mais aussi dans la région (mer Rouge, péninsule Arabique et corne de l'Afrique, région où ils sont toujours présents aujourd'hui.

  18. Proceedings of the 2002 Annual Meeting of the Canadian Mathematics Education Study Group = Actes de la Rencontre Annuelle 2002 du Groupe Canadien d'Etude en Didactique des Mathematiques (26th, Kingston, Ontario, Canada, May 24-28, 2002)

    Science.gov (United States)

    Simmt, Elaine, Ed.; Davis, Brent, Ed.

    2003-01-01

    This submission contains the Proceedings of the 2002 Annual Meeting of the Canadian Mathematics Education Study Group (CMESG), held at Queen's University in Kingston, Ontario. The CMESG is a group of mathematicians and mathematics educators who meet annually to discuss mathematics education issues at all levels of learning. The aims of the Study…

  19. Anti-Ri antibody associated small cell lung carcinoma.

    Science.gov (United States)

    O'Leary, C G; Battley, J E; O'Reilly, S

    2017-05-01

    Anti-neuronal antibody Anti-Ri may be positive in patients with paraneoplastic syndrome associated with certain cancer subtypes. Anti-Ri positivity has been associated with breast, gynaecological and small cell lung cancers. A 69 year-old female presented with a sudden decline in cognition requiring hospital admission. She had an extensive medical history including a significant smoking history and bipolar affective disorder for which she was prescribed lithium. Her cognitive decline was initially attributed to diabetes insipidus secondary to lithium therapy. She made a slow but gradual recovery with treatment. Additional investigations revealed positive Anti-Ri antibody. An occult malignancy screen identified enlarged aorto-pulmonary lymph nodes of indeterminate significance. Following discussion at the regional cardiothoracic multidisciplinary team meeting, three monthly surveillance scans were performed. At month 6 an increase in thoracic adenopathy was seen however endobronchial ultrasound guided biopsy failed to identify malignant cells. Further progression with new supraclavicular adenopathy was seen on repeat imaging 6 months later. A fine need aspirate of an enlarged supraclavicular lymph node was diagnostic for small cell lung cancer, staged as TxN3M0 on positron emission tomography. The patient went on to receive sequential chemo-radiotherapy with a truncated course of carboplatin and etoposide and 50 Gy/25 fractions of thoracic radiotherapy. This case suggests that a positive Anti-Ri antibody may predate the development of clinical or radiological evidence of malignancy. If Anti-Ri positivity is identified, strong consideration should be given to screening for malignancy and regular surveillance. This approach may lead to earlier diagnosis and a better outcome for these patients.

  20. Structure of RiVax: a recombinant ricin vaccine

    Energy Technology Data Exchange (ETDEWEB)

    Legler, Patricia M. [Naval Research Laboratories, 4555 Overlook Avenue, Washington, DC 20375 (United States); Brey, Robert N. [Soligenix Inc., 29 Emmons Drive, Suite C-10, Princeton, NJ 08540 (United States); Smallshaw, Joan E.; Vitetta, Ellen S. [UT Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390-8576 (United States); Millard, Charles B., E-mail: charles.b.millard@us.army.mil [US Army Medical Research and Materiel Command, Frederick, MD 21702-5012 (United States); Naval Research Laboratories, 4555 Overlook Avenue, Washington, DC 20375 (United States)

    2011-09-01

    The X-ray crystal structure (at 2.1 Å resolution) of an immunogen under development as part of a ricin vaccine for humans is presented and structure-based analysis of the results was conducted with respect to related proteins and the known determinants for inducing or suppressing the protective immune response. RiVax is a recombinant protein that is currently under clinical development as part of a human vaccine to protect against ricin poisoning. RiVax includes ricin A-chain (RTA) residues 1–267 with two intentional amino-acid substitutions, V76M and Y80A, aimed at reducing toxicity. Here, the crystal structure of RiVax was solved to 2.1 Å resolution and it was shown that it is superposable with that of the ricin toxin A-chain from Ricinus communis with a root-mean-square deviation of 0.6 Å over 258 C{sup α} atoms. The RiVax structure is also compared with the recently determined structure of another potential ricin-vaccine immunogen, RTA 1–33/44–198 R48C/T77C. Finally, the locations and solvent-exposure of two toxin-neutralizing B-cell epitopes were examined and it was found that these epitopes are within or near regions predicted to be involved in catalysis. The results demonstrate the composition of the RiVax clinical material and will guide ongoing protein-engineering strategies to develop improved immunogens.

  1. ri Kraft : Eesti eksport nõuab Euroopa Liitu minekut / Jüri Kraft ; interv. Sulev Oll

    Index Scriptorium Estoniae

    Kraft, Jüri, 1935-

    2003-01-01

    Kahe kergetööstusettevõtte, Sangari ja Mivari nõukogu esimees, endine ENSV kergetööstusminister Jüri Kraft leiab, et kui Eesti ei astu EL-i ja loobub soodsast ekspordivõimalusest, kordub Eestis 1990. aastate alguse olukord

  2. The GPU-enabled divide-expand-consolidate RI-MP2 method (DEC-RI-MP2).

    Science.gov (United States)

    Bykov, Dmytro; Kjaergaard, Thomas

    2017-02-05

    We report porting of the Divide-Expand-Consolidate Resolution of the Identity second-order Møller-Plesset perturbation (DEC-RI-MP2) method to the graphic processing units (GPUs) using OpenACC compiler directives. It is shown that the OpenACC compiler directives implementation efficiently accelerates the rate-determining step of the DEC-RI-MP2 method with minor implementation effort. Moreover, the GPU acceleration results in a better load balance and thus in an overall scaling improvement of the DEC algorithm. The resulting cross-platform hybrid MPI/OpenMP/OpenACC implementation has scalable and portable performance on heterogeneous HPC architectures. The GPU-enabled code was benchmarked using a reduced version of the S12L test set of Stefan Grimme (Grimme, Chem. Eur. J. 2012, 18, 9955) consisting of supramolecular complexes up to 158 atoms and 4292 contracted basis functions (cc-pVTZ). The test set results demonstrate the general applicability of the DEC-RI-MP2 method showing results consistent with the DEC-RI-MP2 introductory paper (Baudin et al., J. Chem. Phys. 2016, 144, 054102) on molecules of complicated electronic structures. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  3. Euroopa äriühingu mudel ja selle rakendamine finantssektori äriühingute poolt / Ingrid Ulst

    Index Scriptorium Estoniae

    Ulst, Ingrid, 1977-

    2005-01-01

    SE (Euroopa äriühingu) mudeli olemusest ja SE regulatsiooni olulisematest aspektidest, põgusalt Nordea Bank AB praegusest grupistruktuurist ja võimalikust restruktureerimisest. Lisatud tabel: Nordea Bank AB olulisemad grupiettevõtted ja järelevalve (01/01/2004)

  4. Tallinna linnapea Jüri Ratas : Keskerakond ei ole maffia! / Jüri Ratas ; interv. Urmo Soonvald

    Index Scriptorium Estoniae

    Ratas, Jüri, 1978-

    2005-01-01

    Tallinna linnapea Jüri Ratas vastab küsimustele, mis puudutavad Rein Ratase Tallinna Vee nõukogu liikmeks määramist, K-kohukse reklaami seost Keskerakonna valimiskampaaniaga, linnapeaks saamist, koostööd teiste poliitikutega, Edgar Savisaare osa Tallinna linna juhtimises

  5. 33 CFR 100.119 - Newport-Bermuda Regatta, Narragansett Bay, Newport, RI

    Science.gov (United States)

    2010-07-01

    ..., Narragansett Bay, Newport, RI 100.119 Section 100.119 Navigation and Navigable Waters COAST GUARD, DEPARTMENT...-Bermuda Regatta, Narragansett Bay, Newport, RI (a) Regulated area. The regulated area includes all waters of Narragansett Bay, Newport, RI, within the following points (NAD 83): Latitude Longitude 41°27′51...

  6. 76 FR 82000 - Submission for Review: Request for Change to Unreduced Annuity, RI 20-120

    Science.gov (United States)

    2011-12-29

    ... MANAGEMENT Submission for Review: Request for Change to Unreduced Annuity, RI 20-120 AGENCY: U.S. Office of... Unreduced Annuity, RI 20-120. As required by the Paperwork Reduction Act of 1995, (Pub. L. 104-13, 44 U.S.C.... SUPPLEMENTARY INFORMATION: RI 20-120 is designed to collect information the Office of Personnel Management needs...

  7. 76 FR 82000 - Submission for Review: Marital Status Certification Survey, RI 25-7

    Science.gov (United States)

    2011-12-29

    ... MANAGEMENT Submission for Review: Marital Status Certification Survey, RI 25-7 AGENCY: U.S. Office of... Survey, RI 25-7. As required by the Paperwork Reduction Act of 1995, (Pub. L. 104-13, 44 U.S.C. chapter.... SUPPLEMENTARY INFORMATION: RI 25-7, Marital Status Certification Survey, is used to determine whether widows...

  8. 77 FR 28253 - Safety Zone; America's Cup World Series, East Passage, Narragansett Bay, RI

    Science.gov (United States)

    2012-05-14

    ..., Narragansett Bay, RI AGENCY: Coast Guard, DHS. ACTION: Final rule. SUMMARY: The Coast Guard is establishing two... Series, East Passage, Narragansett Bay, RI'' in the Federal Register (77 FR 7025). We received one... of Newport, RI. Discussion of Comments and Changes One comment was received, supporting this rule...

  9. 77 FR 27115 - Newport to Bermuda Regatta, Narragansett Bay, Newport, RI

    Science.gov (United States)

    2012-05-09

    ... SECURITY Coast Guard 33 CFR Part 100 Newport to Bermuda Regatta, Narragansett Bay, Newport, RI AGENCY... Bay, Newport, RI, from 10 a.m. to 3:30 p.m. on Friday, June 15, 2012. A portion of the navigable waters of the East Passage, Narragansett Bay, Newport, RI or its approaches will be closed during the...

  10. 76 FR 82001 - Submission for Review: Alternative Annuity Election, RI 20-80

    Science.gov (United States)

    2011-12-29

    ... MANAGEMENT Submission for Review: Alternative Annuity Election, RI 20-80 AGENCY: U.S. Office of Personnel... on a revised information collection request (ICR) 3206-0168, Alternative Annuity Election, RI 20-80.... SUPPLEMENTARY INFORMATION: RI 20-80 is used for individuals who are eligible to elect whether to receive a...

  11. Äriühingute vastastikune tunnustamine ja asukohavahetus Euroopa Liidus / Andres Vutt

    Index Scriptorium Estoniae

    Vutt, Andres, 1969-

    2007-01-01

    Äriühingute vastastikuse tunnustamise põhimõtetest ja võimalustest, kuidas saab Euroopa Liidus muuta äriühingu asukohta ühest riigist teise ning mida tuleb Eestil seoses sellega arvestada. Äriühingute asukohavahetusest Euroopa Kohtu lahendites. Artikkel on valminud ETF-i grandi 6747 abil

  12. Nooruslik kaupmeheemand kavatseb äri laiendada / Hille Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Hille, 1941-2014

    2006-01-01

    Vt. ka Postimees : na russkom jazõke 23. märts lk. 8. Tallinnas Vana-Kalamaja tänaval paikneva Alma Äri omanik Alma Sooäär avas oma esimese poe enam kui 15 aastat tagasi Nõmmel, praegu plaanib poeomanik majapidamistarvete äri laiendamist. Kaart: Alma Äri

  13. Bioaccumulation of metals in three freshwater mussel species exposed in situ during and after dredging at a coal ash spill site (Tennessee Valley Authority Kingston Fossil Plant).

    Science.gov (United States)

    Otter, Ryan R; McKinney, David; Brown, Bobby; Lainer, Susan; Monroe, William; Hubbs, Don; Read, Bob

    2015-06-01

    On December 22, 2008, a dike containing coal fly ash at the Tennessee Valley Authority Kingston Fossil Plant (TN, USA) failed, and within months, dredging operations began to remove ash-contaminated sediments. The purpose of this study was to investigate differences in the bioaccumulation of metals in three mussel species during and after dredging operations. Mussels were caged for approximately 1 year during dredging and after, and then mussel condition index values and As, Cd, Cr, Pb, Ni, Se, Hg, U, Fe, Mg, Al, Sb, Ba, Be, Co, Cu, Mn, Mo, Ag, Sr, Tl, V, and Zn concentrations in soft tissue were determined via inductively coupled plasma-mass spectrometery. Overall, the differences observed in metal bioaccumulation and mussel health suggest that mussels in the immediate downstream area of the dredging site may have been impacted, as evidenced by a significant decrease in mussel condition index values, but that this impact did not result in increased tissue concentrations of metals.

  14. Midwives’ knowledge and attitudes when encountering Gender-Based Violence in their practice at a maternity-hospital in Kingston, Jamaica

    Directory of Open Access Journals (Sweden)

    Cynthia Pearl Pitter

    2016-02-01

    Full Text Available Introduction: Gender-based violence (GBV can have devastating consequences for pregnancy because both mother and child are at risk. Midwives are in a strategic position to identify and empower pregnant women experiencing GBV; however, currently midwives in Jamaica are not required to screen for GBV, neither are they prepared to do so. Aim: This study forms the baseline of a larger study designed to improve the capacity of midwives to identify and treat pregnant women experiencing GBV in Jamaica. This specific component assessed midwives’ knowledge and attitudes when encountering GBV in their practice in Kingston, Jamaica. Methods: A qualitative study design was used. Six practicing midwives were purposely selected to participate in a focus group discussion at the antenatal clinic of a hospital in Kingston, Jamaica. Results: All six respondents said it was very important to screen for GBV among pregnant women in their care. The findings from their report revolved around six themes, namely midwives have suboptimal knowledge, are exposed to women experiencing GBV in pregnancy, lack professional preparedness, report gaps in the institutional framework to guide their practice, are concerned for their safety and security, and are willing to intervene. Conclusion: This study confirmed that midwives are aware of the problem and are willing to intervene but are faced with lack of formal procedures to detect and treat pregnant women who are experiencing GBV. Findings could be used to inform a protocol which is being developed to guide midwives’ practice. Findings could also be incorporated in the national strategy to eliminate GBV.

  15. Genetic transformation of Begonia tuberhybrida by Ri rol genes.

    Science.gov (United States)

    Kiyokawa, S; Kikuchi, Y; Kamada, H; Harada, H

    1996-04-01

    We have developed an Agrobacterium -mediated transformation system for commercial Begonia species. The leaf explants of Begonia semperflorens, Begonia x hiemalis and B. tuberhybrida were inoculated with Agrobacterium tumefaciens LBA4404 harboring a binary vector pBI121 which contains rolA, B and C genes of an agropine type Ri plasmid (pRiA4b). Kanamycin resistant shoots of B. tuberhybrida were obtained on MS agar medium supplemented with 0.1 mg/l NAA, 0.5 mg/l BA, 500 mg/l claforan and 100 mg/l kanamycin. These shoots exhibited GUS activity and Southern analysis showed a single copy insertion into the genome. When the transgenic plants were transferred to soil, they displayed the phenotype specific to the transgenic plants by A. rhizogenes such as dwarfness, delay of flowering, and wrinkled leaves and petals.

  16. Kolonel Jüri Kadaku uus missioon / Virkko Lepassalu

    Index Scriptorium Estoniae

    Lepassalu, Virkko, 1971-

    2009-01-01

    Eesti ja Aserbaidžaani suhetest ning kohalikust poliitilisest olukorrast. Kohalike oludega tuttav kaitsejõudude erukoloneli ja praeguse Euroülikooli professori Jüri Kadaku hinnangul on Eesti ettevõtjatel kõige otstarbekam teha investeeringuid ehitusmaterjalide müüki ja IT-sektorisse. Lisa: Ühe akna printsiip; Kuhu investeerida?. Lisatud foto: Mehed mustas: president Alijev ja president Ilves 13. jaanuaril Bakuus

  17. USA kahepaiksest mängust / Jüri Lina

    Index Scriptorium Estoniae

    Lina, Jüri, 1949-

    2000-01-01

    Sama artikkel on ilmunud ka Eesti 2000 : sõltumatu almanahh ühiskonna ja vaimuelu küsimustes nr. 4 ja nr. 6. Autori väitel on USA muu hulgas huvitatud maakera rahvastiku drastilisest vähendamisest, seepärast ongi pärast Teist maailmasõda kunstlikult lõkkele puhutud sadu sõjalisi konflikte. Lisatud Jüri Lina lühielulugu lk. 23

  18. Diurnal variations in brain iron concentrations in BXD RI mice.

    Science.gov (United States)

    Unger, E L; Jones, B C; Bianco, L E; Allen, R P; Earley, C J

    2014-03-28

    Under normal and dietary iron deficiency conditions, the BXD recombinant inbred (RI) strains of mice show large variations in regional brain iron concentration, particularly in the ventral midbrain (VMB). In a study utilizing just one of the BXD strains, diurnal changes in subregional brain iron concentration were found, which were dependent on the brain region and sex of the mice. The focus of this study was to determine if diurnal changes in VMB can be found across other BXD RI strains and whether a diurnal effect would be common to all strains or variable across strains similar to the large strain variability in iron concentrations determined during the first part of the light phase. Eight RI (BXD type) strains of mice of both sexes were selected for this study. Mice were sacrificed at postnatal day 120: half in the light phase (LP) and half in the dark phase (DP) of the light-dark cycle. Iron concentrations were determined in VMB, which was the primary region of interest, and five other brain regions. Exploratory analysis was also done on liver and spleen iron concentrations to assess for diurnal changes. Three strains showed clear diurnal variation in iron in the VMB and the others strains showed diurnal variations in other regions. These changes were not equally apparent in both sexes. Exploratory analysis also found strain×sex-dependent diurnal differences in spleen and liver iron. In conclusion, significant brain-regional-specific diurnal changes in total iron concentrations were found in a selection of BXD RI mice. Sex and strain are functional determinates of which regions will be affected and in what direction the affect will be. The study provides an animal model for future work into determining the biological and genetic basis of circadian influences on VMB iron homeostasis. Copyright © 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

  19. Uudised : Fääri ooper Tallinnas. Sigur Ros Tallinnas

    Index Scriptorium Estoniae

    2008-01-01

    10.-12. septembrini mängitakse Tallinnas Kultuurikatlas fääri helilooja Sunleif Rasmusseni ooperit "Hullu mehe aias", lavastajaks Robert Annus. 23. augustil annab Rock Cafés kontserdi Islandi eksperimentaalrocki ansambel Sigur Ros, kes esitleb oma viiendat albumit "Med sud i eyrum vid spilum endalaust" (mida võiks tõlkida "Mängime lõppematult, sumin kõrvus"

  20. Moskvast tuli Eestisse Hõbe-Jüri / Kristiina Davidjants

    Index Scriptorium Estoniae

    Davidjants, Kristiina, 1974-

    2004-01-01

    Moskvas lõppes XXVI rahvusvaheline filmifestival. Festivali programmi kuulus ka Renee Reinumäe, Jaak Kilmi noortefilm, mis sai žürii eripreemia, Hõbedase Püha Jüri. Peapreemia sai venelase Dmitri Meshijevi "Omad". Noorte lootustandvate režissööride programmis oli huvitav prantslase Christophe Honoré "Minu ema". Lisatud auhinnatute nimekiri ning nimekiri "Eesti filmide tähtsamaid autasusid"

  1. Development of a Bayesian Belief Network Runway Incursion Model

    Science.gov (United States)

    Green, Lawrence L.

    2014-01-01

    In a previous paper, a statistical analysis of runway incursion (RI) events was conducted to ascertain their relevance to the top ten Technical Challenges (TC) of the National Aeronautics and Space Administration (NASA) Aviation Safety Program (AvSP). The study revealed connections to perhaps several of the AvSP top ten TC. That data also identified several primary causes and contributing factors for RI events that served as the basis for developing a system-level Bayesian Belief Network (BBN) model for RI events. The system-level BBN model will allow NASA to generically model the causes of RI events and to assess the effectiveness of technology products being developed under NASA funding. These products are intended to reduce the frequency of RI events in particular, and to improve runway safety in general. The development, structure and assessment of that BBN for RI events by a Subject Matter Expert panel are documented in this paper.

  2. Preliminary Beam Irradiation Test for RI Production Targets at KOMAC

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Sang Pil; Kwon, Hyeok Jung; Kim, Han Sung; Cho, Yong Sub; Seol, Kyung Tae; Song, Young Gi; Kim, Dae Il; Jung, Myung Hwan; Kim, Kye Ryung; Min, Yi Sub [KAERI, Daejeon (Korea, Republic of)

    2016-05-15

    The new beamline and target irradiation facility has been constructed for the production of therapeutic radio-isotope. Sr-82 and Cu-67 were selected as the target isotope in this facility, they are promising isotope for the PET imaging and cancer therapy. For the facility commissioning, the irradiation test for the prototype-target was conducted to confirm the feasibility of radio-isotope production, the proto-type targets are made of RbCl pellet and the natural Zn metal for Sr-82 and Cu-67 production respectively, In this paper, an introduction to the RI production targetry system and the results of the preliminary beam irradiation test are discussed. the low-flux beam irradiation tests for proto-type RI target have been conducted. As a result of the beam irradiation tests, we could obtain the evidence of Sr-82 and Cu-67 production, have confirmed the feasibility of Sr-82 and Cu-67 production at KOMAC RI production facility.

  3. Quarry residuals RI/FS scoping document. [Weldon Spring quarry

    Energy Technology Data Exchange (ETDEWEB)

    1991-10-01

    The purpose of this document is to serve as a planning tool for the implementation of the Quarry Residual Remedial Investigation/Feasibility Study (RI/FS) process and to provide direct input to revising and updating the 1988 Work Plan for the Weldon Spring Site Remedial Action Project (WSSRAP) Remedial Investigation/Feasibility Study-Environmental Impact Statement for the Weldon Spring Site (RI/FS-EIS) (Peterson et al. 1988) for this effort. The scoping process is intended to outline the tasks necessary to develop and implement activities in compliance with the Comprehensive Environmental Response, Compensation and Liability Act-National Environmental Policy Act (CERCLA-NEPA) process from detailed planning through the appropriate decision document. In addition to scoping the entire process, this document will serve as the primary tool for planning and accomplishing all activities to be developed in the Quarry Residual RI/FS Work Plan. Subsequent tasks are difficult to plan at this time. 10 refs., 5 figs., 5 tabs.

  4. ri Pihl : Rahvale räägitakse valet, ilget valet / Jüri Pihl ; interv. Peeter Ernits

    Index Scriptorium Estoniae

    Pihl, Jüri, 1954-

    2005-01-01

    Justiitsministeeriumi kantsler Jüri Pihl kaitseb justiitsministeeriumi plaani korruptantide tabamiseks. Lisa: Justiitsminister Ken-Marti Vaheri nädal. Vt. ka: Kas justiitsminister Ken-Marti Vaheri korruptantide avastamise plaani varjutab stalinismi vari? Küsimusele vastavad Sotsiaaldemokraatliku erakonna esimees Ivari Padar, Keskerakonna liige Evelyn Sepp, Reformierakonna esimees Andrus Ansip, Rahvaliidu fraktsiooni esimees Jaanus Männik, sotsiaalliberaal Liina Tõnisson, Reformierakonna fraktsiooni esimees Peep Aru ja Isamaaliidu liige Mart Laar. Vastuseks vt. ka Ivar Tallo repliiki 7. apr. Maalehes

  5. Space and Salvation in Colette's Chéri and La Fin de Chéri

    Directory of Open Access Journals (Sweden)

    Ann Leone Philbrick

    1984-01-01

    Full Text Available Colette's critics often seem to dismiss all but her autobiographical creatures as whimsical and inarticulate. Her characters are frequently less eloquent than the spaces they create and inhabit; this observation offers an approach to Chéri and La Fin de Chéri that invites us to read them as two of Colette's most ambitious and authentic works. Here are stories of compromises with the containers of one's life and identity: streets, salons, boudoirs, and, ultimately, the body. Indeed, the self and its containers function symbiotically. Chéri makes no effort to direct this relationship, and kills himself when the world finally seems inscrutable and formless; his older mistress, Léa, responds joyfully—or with melancholic respect—to the surfaces and limits of her world. We are left with a harsher insight into Colette's vision than we are accustomed to. She suggests that survival lies not in the endless definition of one's place in the world, but in its recognition and a loving, even fearing, homage.

  6. 77 FR 5581 - Submission for Review: Financial Resources Questionnaire (RI 34-1, RI 34-17) and Notice of Amount...

    Science.gov (United States)

    2012-02-03

    ... information collection request (ICR) 3206-0167, Financial Resources Questionnaire (RI 34-1 and RI 34-17) and...; 3. Enhance the quality, utility, and clarity of the information to be collected; and 4. Minimize the... mail to [email protected] or faxed to (202) 395-6974. SUPPLEMENTARY INFORMATION: Financial...

  7. Improving Forecast Skill by Assimilation of AIRS Cloud Cleared Radiances RiCC

    Science.gov (United States)

    Susskind, Joel; Rosenberg, Robert I.; Iredell, Lena

    2015-01-01

    ECMWF, NCEP, and GMAO routinely assimilate radiosonde and other in-situ observations along with satellite IR and MW Sounder radiance observations. NCEP and GMAO use the NCEP GSI Data Assimilation System (DAS).GSI DAS assimilates AIRS, CrIS, IASI channel radiances Ri on a channel-by-channel, case-by-case basis, only for those channels i thought to be unaffected by cloud cover. This test excludes Ri for most tropospheric sounding channels under partial cloud cover conditions. AIRS Version-6 RiCC is a derived quantity representative of what AIRS channel i would have seen if the AIRS FOR were cloud free. All values of RiCC have case-by-case error estimates RiCC associated with them. Our experiments present to the GSI QCd values of AIRS RiCC in place of AIRS Ri observations. GSI DAS assimilates only those values of RiCC it thinks are cloud free. This potentially allows for better coverage of assimilated QCd values of RiCC as compared to Ri.

  8. Kinnisvaraäri Narva moodi / Koit Brinkmann

    Index Scriptorium Estoniae

    Brinkmann, Koit

    2008-01-01

    Ilmunud ka: Viru Prospekt 26. juuni lk. 9. Narva linna valitseb sõpruskond, kes ajab juba mitmeid aastaid kinnisvaraäri Narva linna varadega. Sõpruskonna tuumiku moodustavad Aleksandr Moissejev, Fjodor Ovsjannikov ja Stanislav Sorokin. Vt. samas: Narva linnal väga imelikud rendilepingud; Kes on kes Narvas; Kuidas müüdi ASi Narva Heakorrastus aktsiad; Enamus linnafirmade müüdud kinnistuid jõudis ühe sõpruskonna firmade valdusesse. Küsimustele vastavad Narva linnavolikogu juht Mihhail Stalnuhhin ja Narva linnavolikogu liige Aleksandr Moissejev. Kommenteerib Aivo Peterson

  9. Eesti estamp sisepaguluses : graafikatriennaal / Jüri Hain

    Index Scriptorium Estoniae

    Hain, Jüri, 1941-

    2004-01-01

    Graafikute grupinäitused G-galeriis (kuraator Loit Jõekalda, osalevad Vive Tolli, Vello Vinn, Silvi Liiva, Raul Meel, Mare Vint, Jüri Kass, Ülle Marks, Maria-Kristiina Ulas) kuni 25. IX, Aatriumi galeriis kuni 23. IX, Soome Instituudis kuni 30. IX, Vappu Thurlowi kureeritud näitus "Lähenemised" Estonia kontserdisaalis kuni 15. X, Virge Jõekalda näitus "Vaikus" Ungari Instituudis kuni 27. IX, Loit Jõekalda näitus "Must ja valge" galeriis 36 kuni 19. IX

  10. Barriers and facilitators to HIV testing among young men who have sex with men and transgender women in Kingston, Jamaica: a qualitative study.

    Science.gov (United States)

    Logie, Carmen H; Lacombe-Duncan, Ashley; Brien, Natasha; Jones, Nicolette; Lee-Foon, Nakia; Levermore, Kandasi; Marshall, Annecka; Nyblade, Laura; Newman, Peter A

    2017-04-04

    Young men who have sex with men (MSM) in Jamaica have the highest HIV prevalence in the Caribbean. There is little information about HIV among transgender women in Jamaica, who are also overrepresented in the Caribbean epidemic. HIV-related stigma is a barrier to HIV testing among Jamaica's general population, yet little is known of MSM and transgender women's HIV testing experiences in Jamaica. We explored perceived barriers and facilitators to HIV testing among young MSM and transgender women in Kingston, Jamaica. We implemented a community-based research project in collaboration with HIV and lesbian, gay, bisexual and transgender (LGBT) agencies in Kingston. We held two focus groups, one with young (aged 18-30 years) transgender women (n = 8) and one with young MSM (n = 10). We conducted 53 in-depth individual semi-structured interviews focused on HIV testing experiences with young MSM (n = 20), transgender women (n = 20), and community-based key informants (n = 13). We conducted thematic analysis to identify, analyze, and report themes. Participant narratives revealed social-ecological barriers and facilitators to HIV testing. Barriers included healthcare provider mistreatment, confidentiality breaches, and HIV-related stigma: these spanned interpersonal, community and structural levels. Healthcare provider discrimination and judgment in HIV testing provision presented barriers to accessing HIV services (e.g. treatment), and resulted in participants hiding their sexual orientation and/or gender identity. Confidentiality concerns included: clinic physical arrangements that segregated HIV testing from other health services, fear that healthcare providers would publicly disclose their status, and concerns at LGBT-friendly clinics that peers would discover they were getting tested. HIV-related stigma contributed to fear of testing HIV-positive; this intersected with the stigma of HIV as a "gay" disease. Participants also anticipated healthcare provider

  11. Analysis of MRI and RI defecogram for quantitative evaluation of defecation

    Energy Technology Data Exchange (ETDEWEB)

    Tsukahara, Yuuki; Ikawa, Hiromichi; Okamoto, Shinya; Masuyama, Hiroaki; Taniuchi, Mayumi; Okajima, Hideaki; Konuma, Kunio; Kohno, Miyuki [Kanazawa Medical Univ., Uchinada, Ishikawa (Japan)

    2001-12-01

    For quantitative analysis of the rectal emptying, RI defecogram was performed. The object were Hirschsprung's disease 9, anorectal anomary 6 patients. Evacuation time of Hirschsprung's disease group and anorectal anomary group were significantly prolonged compared with that of normal group. RI defecogram revealed that the rectal evacuation of Hirschsprung's disease group and anorectal anomary group were impaired. RI defecogram is useful for quantitative evacuation of defecation. (author)

  12. A role for accessory genes rI.-1 and rI.1 in the regulation of lysis inhibition by bacteriophage T4.

    Science.gov (United States)

    Golec, Piotr; Wiczk, Aleksandra; Majchrzyk, Anna; Łoś, Joanna M; Węgrzyn, Grzegorz; Łoś, Marcin

    2010-12-01

    Lysis inhibition (LIN) is a known feature of the T-even family of bacteriophages. Despite its historical role in the development of modern molecular genetics, many aspects of this phenomenon remain mostly unexplained. The key element of LIN is an interaction between two phage-encoded proteins, the T holin and the RI antiholin. This interaction is stabilized by RIII. In this report, we demonstrate the results of genetic experiments which suggest a synergistic action of two accessory proteins of bacteriophage T4, RI.-1, and RI.1 with RIII in the regulation of LIN.

  13. Ethanol Inhibits High-Affinity Immunoglobulin E Receptor (FcεRI) Signaling in Mast Cells by Suppressing the Function of FcεRI-Cholesterol Signalosome

    Science.gov (United States)

    Draberova, Lubica; Paulenda, Tomas; Halova, Ivana; Potuckova, Lucie; Bugajev, Viktor; Bambouskova, Monika; Tumova, Magda; Draber, Petr

    2015-01-01

    Ethanol has multiple effects on biochemical events in a variety of cell types, including the high-affinity immunoglobulin E receptor (FcεRI) signaling in antigen-activated mast cells. However, the underlying molecular mechanism remains unknown. To get better understanding of the effect of ethanol on FcεRI-mediated signaling we examined the effect of short-term treatment with non-toxic concentrations of ethanol on FcεRI signaling events in mouse bone marrow-derived mast cells. We found that 15 min exposure to ethanol inhibited antigen-induced degranulation, calcium mobilization, expression of proinflammatory cytokine genes (tumor necrosis factor-α, interleukin-6, and interleukin-13), and formation of reactive oxygen species in a dose-dependent manner. Removal of cellular cholesterol with methyl-β-cyclodextrin had a similar effect and potentiated some of the inhibitory effects of ethanol. In contrast, exposure of the cells to cholesterol-saturated methyl-β-cyclodextrin abolished in part the inhibitory effect of ethanol on calcium response and production of reactive oxygen species, supporting lipid-centric theories of ethanol action on the earliest stages of mast cell signaling. Further studies showed that exposure to ethanol and/or removal of cholesterol inhibited early FcεRI activation events, including tyrosine phosphorylation of the FcεRI β and γ subunits, SYK kinases, LAT adaptor protein, phospholipase Cγ, STAT5, and AKT and internalization of aggregated FcεRI. Interestingly, ethanol alone, and particularly in combination with methyl-β-cyclodextrin, enhanced phosphorylation of negative regulatory tyrosine 507 of LYN kinase. Finally, we found that ethanol reduced passive cutaneous anaphylactic reaction in mice, suggesting that ethanol also inhibits FcεRI signaling under in vivo conditions. The combined data indicate that ethanol interferes with early antigen-induced signaling events in mast cells by suppressing the function of FcεRI

  14. Ethanol Inhibits High-Affinity Immunoglobulin E Receptor (FcεRI) Signaling in Mast Cells by Suppressing the Function of FcεRI-Cholesterol Signalosome.

    Science.gov (United States)

    Draberova, Lubica; Paulenda, Tomas; Halova, Ivana; Potuckova, Lucie; Bugajev, Viktor; Bambouskova, Monika; Tumova, Magda; Draber, Petr

    2015-01-01

    Ethanol has multiple effects on biochemical events in a variety of cell types, including the high-affinity immunoglobulin E receptor (FcεRI) signaling in antigen-activated mast cells. However, the underlying molecular mechanism remains unknown. To get better understanding of the effect of ethanol on FcεRI-mediated signaling we examined the effect of short-term treatment with non-toxic concentrations of ethanol on FcεRI signaling events in mouse bone marrow-derived mast cells. We found that 15 min exposure to ethanol inhibited antigen-induced degranulation, calcium mobilization, expression of proinflammatory cytokine genes (tumor necrosis factor-α, interleukin-6, and interleukin-13), and formation of reactive oxygen species in a dose-dependent manner. Removal of cellular cholesterol with methyl-β-cyclodextrin had a similar effect and potentiated some of the inhibitory effects of ethanol. In contrast, exposure of the cells to cholesterol-saturated methyl-β-cyclodextrin abolished in part the inhibitory effect of ethanol on calcium response and production of reactive oxygen species, supporting lipid-centric theories of ethanol action on the earliest stages of mast cell signaling. Further studies showed that exposure to ethanol and/or removal of cholesterol inhibited early FcεRI activation events, including tyrosine phosphorylation of the FcεRI β and γ subunits, SYK kinases, LAT adaptor protein, phospholipase Cγ, STAT5, and AKT and internalization of aggregated FcεRI. Interestingly, ethanol alone, and particularly in combination with methyl-β-cyclodextrin, enhanced phosphorylation of negative regulatory tyrosine 507 of LYN kinase. Finally, we found that ethanol reduced passive cutaneous anaphylactic reaction in mice, suggesting that ethanol also inhibits FcεRI signaling under in vivo conditions. The combined data indicate that ethanol interferes with early antigen-induced signaling events in mast cells by suppressing the function of FcεRI

  15. Kas e-äri võrdub pankrotiga / Priit Vaikmaa

    Index Scriptorium Estoniae

    Vaikmaa, Priit

    2001-01-01

    E-äride pankrotilaine aastal 2000. Firmadevaheline äri internetis - B2B (business-to-business). B2B ärikeskkondade kodulehekülgede aadressid. B2B ja e-äri lahenduste pakkujad Eestis. Diagramm: B2B e-kommertsi prognoositud käive 2004.a.

  16. Elagu eesti energia : Jaan ja Jüri Ojaver, Paul Rodgers / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    2001-01-01

    Paul Rodgersi, Jüri ja Jaan Ojaveri ühisnäitusest "Koostöö" Rakvere Kesklinna galeriis. P. Rodgersilt ja Jüri Ojaverilt on väljas Viinist "Eesti energia" näituselt naasnud tööd, Jaan Ojaverilt minimalistlikud tööriistad-objektid

  17. 78 FR 4172 - Submission for Review: RI 25-15, Notice of Change in Student's Status

    Science.gov (United States)

    2013-01-18

    ... From the Federal Register Online via the Government Publishing Office OFFICE OF PERSONNEL MANAGEMENT Submission for Review: RI 25-15, Notice of Change in Student's Status AGENCY: U.S. Office of.... SUPPLEMENTARY INFORMATION: RI 25-15, Notice of Change in Student's Status, is used to collect sufficient...

  18. 33 CFR 80.145 - Race Point, MA, to Watch Hill, RI.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Race Point, MA, to Watch Hill, RI. 80.145 Section 80.145 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY..., RI. (a) Except inside lines specifically described in this section, the 72 COLREGS shall apply on the...

  19. 33 CFR 100.112 - Swim the Bay, Narragansett Bay, Narragansett, RI.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Swim the Bay, Narragansett Bay, Narragansett, RI. 100.112 Section 100.112 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND..., Narragansett Bay, Narragansett, RI. (a) Regulated area. All waters of the East Passage of Narragansett Bay...

  20. 76 FR 39927 - Submission for Review: Marital Status Certification Survey, RI 25-7

    Science.gov (United States)

    2011-07-07

    ... From the Federal Register Online via the Government Publishing Office OFFICE OF PERSONNEL MANAGEMENT Submission for Review: Marital Status Certification Survey, RI 25-7 AGENCY: U.S. Office of... to (202) 606-0910. SUPPLEMENTARY INFORMATION: RI 25-7, Marital Status Certification Survey, is used...

  1. Data of evolutionary structure change: 1DEAA-2RI1A [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1DEAA-2RI1A 1DEA 2RI1 A A -MRLIPLTTAEQVGKWAARHIVNRINAFKPTADRPFVLG.../line> ASP CA 284 PHE CA 347 SER CA 228 1DEA... A 1DEAA ALVEMHKAGQVSFK 1DEA A 1DEAA GLU CA 160 ASP CA 224 VAL CA 284 1DEA

  2. Linnapea, keda rõõmustab titekisa / Jüri Ratas ; interv. Riina Luik

    Index Scriptorium Estoniae

    Ratas, Jüri, 1978-

    2006-01-01

    Tallinna linnapea vastab küsimustele, mis puudutavad tema suhtumist opositsiooni kriitikasse, linna juhtimist, perekonda, lapsepõlve, spordiga tegelemist, sõpruskonda, eraettevõtlusest loobumist ning suhteid kirikuga. Lisa: Jüri Ratas (27). Vt. samas lühiintervjuud linnapea abikaasa Karin Ratasega. Kommenteerib Jüri Ratase endine klassijuhataja Nõmme gümnaasiumist, võrkpallitreener Raimund Pundi

  3. 77 FR 43514 - Anchorage Regulations; Narragansett Bay and Rhode Island Sound, RI

    Science.gov (United States)

    2012-07-25

    ... Sound, RI AGENCY: Coast Guard, DHS. ACTION: Final rule. SUMMARY: The Coast Guard is removing an obsolete... Island Sound south of Brenton Point, Rhode Island, for use by vessels waiting to enter Narragansett Bay... Rhode Island Sound, RI,'' in the Federal Register (76 FR 15246). We received nine comments on the...

  4. Tüüri ava(sta)mas, kuid mitte ainult / Igor Garšnek

    Index Scriptorium Estoniae

    Garšnek, Igor, 1958-

    2011-01-01

    Kahest kontserdist Estonia kontserdisaalis - 4. märtsil ERSO ja Herbert Schuch (klaver) Olari Eltsi dirigeerimisel, kavas Tüüri Sümfoonia nr 8, Pärdi "Nekroloog" ja Ullmanni Klaverikontsert ning 10. märtsil Erkki-Sven Tüüri autorikontsert, kus esinesid Eesti Filharmoonia Kammerkoor ja Sinfonietta Riga Daniel Reussi juhatusel

  5. Usefulness of measurement of blood flow by RI plethysmography

    Energy Technology Data Exchange (ETDEWEB)

    Kawakami, Kenji; Ling, Qing Cheng; Mori, Yutaka; Tanaka, Uzuru; Shimada, Takao [Jikei Univ., Tokyo (Japan). School of Medicine

    1997-03-01

    We have developed the RI plethysmography, and have applied it to ordinary clinic diagnosis and the evaluation of treatment. The subjects were 58 cases (39 cases of the obstruction of the peripheral blood circulation: ASO 24 cases, TAO 4 cases and arterial sclerotic change 11 cases; the non-abnormal control was 19 cases). The clinical benefit of this method was evaluated. In the cases with 1 and 2 degrees of Fontaine`s classification and ASO and TAO, the blood flow of legs measured by our method significantly decreased in association with symptoms and angiographic findings. This method is suitable to the determination of angiography and evaluation of the effect of treatment. (author)

  6. Bir olgu nedeniyle klasik ksantinüri

    OpenAIRE

    Serdaroğlu, Erkin; Ural, Rana; Ağın, Hasan; Bak, Mustafa

    2003-01-01

    Pürin metabolizmasının kalıtsal bir bozukluğu olan ksantinüri, ürolitiyazisin nadir görülen bir nedenidir. Üç aylıktan itibaren kum dökme ve kanlı idrar yapma yakınmaları olan, ilk kez 9 aylıkken anuri ve böbrek yetmezliği bulguları ile başvurduğu bir merkezde, her iki böbreğinde çok sayıda opak olmayan taşlar saptanarak çift taraflı perkütan nefrostomi açılan ve tekrarlayan nefrolitiyazis nedeniyle iki kez nefrolitotomi uygulanan olgu, 30 aylıkken hastanemize başvurdu. Yapılan me...

  7. The Birth Satisfaction Scale-Revised Indicator (BSS-RI).

    Science.gov (United States)

    Martin, Colin R; Hollins Martin, Caroline; Redshaw, Maggie

    2017-08-29

    The current study sought to develop a short birth satisfaction indicator utilising items from the Birth Satisfaction Scale-Revised (BSS-R) for use as a brief measure of birth satisfaction and as a possible key performance indicator for perinatal service delivery evaluation. Building on the recently developed BSS-R, the study aimed to develop a simplified version of the instrument to assess birth satisfaction easily that could work as a short evaluative measure of clinical service delivery for labour and birth that is consistent with policy documents, placing women at the centre of the birth experience. The six item Birth Satisfaction Scale-Revised Indicator (BSS-RI) was embedded within the 2014 National Maternity Survey for England. A random selection of mothers who had given birth in a two week period in England were surveyed three months after the birth. Using a two-stage design and split-half dataset, exploratory factor analysis, confirmatory factor analysis, internal consistency, convergent, divergent and known-groups discriminant validity evaluation were conducted in a secondary analysis of the survey data. Using this large population based survey of recent mothers the short revised measure was found to comprise two distinct domains of birth satisfaction, 'stress and emotional response to labour and birth' and 'quality of care'. The psychometric qualities of the tool were robust as were the indices of validity and reliability evaluated. The BSS-RI represents a short easily administered and scored measure of women's satisfaction with care and the experience of labour and birth. The instrument is potentially useful for researchers, service evaluation and policy makers.

  8. Äriühingu juhatuse liikme teenistusalane suhe : [bakalaureusetöö] / Anneli Kiljako ; Tartu Ülikool, õigusteaduskond ; juhendaja: Inge-Maret Orgo

    Index Scriptorium Estoniae

    Kiljako, Anneli

    1999-01-01

    Äriühingu juhatuse liikme teenistusalase suhtega seonduvad probleemid, äriühingu juhatuse liikme ja ja äriühingu vahelise lepingu sõlmimine, poolte õigused, kohustused, vastutus; juhtimislepingu lõppemine

  9. Thirty-year trends in incidence and age-distribution of prostate cancer in Kingston and St Andrew, Jamaica, 1978-2007.

    Science.gov (United States)

    Gibson, T N; Hanchard, B; Waugh, N; McNaughton, D

    2011-01-01

    To investigate the trends in incidence and age-distribution of prostate cancer in Kingston and St Andrew (KSA), Jamaica, over the 30-year period 1978-2007. From published Jamaica Cancer Registry (JCR) data, we extracted age-standardized rates of prostate cancer for the six 5-year reporting periods that comprised the 30-year study span, and from the archived files of the JCR, the patient ages at diagnosis for all prostate cancer cases recorded over the 30-year period were extracted. The results were compared with data from other black populations. The incidence of prostate cancer in KSA, Jamaica, is lower than that in black men in the United States and United Kingdom. The KSA incidence showed a progressive increase since the 1983-1987 reporting period, and the greatest 5-year percentage increases were seen over the period 1983 to 1997. Men in the 60-74-year age group were the commonest contributors to prostate cancer total in all 5-year periods examined, and between 1988 and 2007, there were increases in the proportionate contributions from the 25-59 and 60-74-year age groups, and a decrease in contribution from men aged 75 years and older. The incidence of prostate cancer in KSA, Jamaica, has been progressively increasing since 1983, and there has been a concomitant increase in the proportionate contribution from younger men. Continued increase is likely over the next several years, but KSA currently appears to be a relatively low-risk region for prostate cancer, compared to black populations in developed Western countries.

  10. Äri- ja ettevõtluskeeldude piiriülene mõju / Maarja Torga, Juhan Sarv

    Index Scriptorium Estoniae

    Torga, Maarja, 1984-

    2017-01-01

    Eestis kohaldatud äri- ja ettevõtluskeeldude piiriülesest mõjust ning välisriigis kohaldatud äri- ja ettevõtluskeelu mõjust Eestis. Äri- ja ettevõtluskeeldude piiriülesest tsiviilõiguslikust ja karistusõiguslikust mõjust. Sisaldab asjakohast kohtupraktikat

  11. 76 FR 23193 - Traffic Separation Schemes: In the Approaches to Portland, ME; Boston, MA; Narragansett Bay, RI...

    Science.gov (United States)

    2011-04-26

    ... Portland, ME; Boston, MA; Narragansett Bay, RI and Buzzards Bay, MA; Chesapeake Bay, VA, and Cape Fear... Portland, ME; in the approaches to Boston, MA; in the approaches to Narragansett Bay, RI and Buzzards Bay... Portland, ME; Boston, MA; Narragansett Bay, RI and Buzzards Bay, MA; Chesapeake Bay, VA; and Cape Fear...

  12. Remedial Investigation/Feasibility Study (RI/FS) process, elements and techniques guidance

    Energy Technology Data Exchange (ETDEWEB)

    1993-12-01

    This manual provides detailed guidance on Remedial Investigation/Feasibility Studies (RI/FSs) conducted pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) at Department of Energy (DOE) facilities. The purpose of the RI/FS, to assess the risk posed by a hazardous waste site and to determine the best way to reduce that risk, and its structure (site characterization, risk assessment, screening and detailed analysis of alternatives, etc.) is defined in the National Oil and Hazardous Substances Pollution Contingency Plan (NCP) and further explained in the Environmental Protection Agency`s (EPA`s) Guidance for Conducting Remedial Investigations and Feasibility Studies Under CERCLA (Interim Final) 540/G-89/004, OSWER Directive 9355.3-01, October 1988. Though issued in 1988, the EPA guidance remains an excellent source of information on the conduct and structure of an RI/FS. This document makes use of supplemental RI/FS-related guidance that EPA has developed since its initial document was issued in 1988, incorporates practical lessons learned in more than 12 years of experience in CERCLA hazardous site remediation, and drawing on those lessons, introduces the Streamlined Approach For Environmental Restoration (SAFER), developed by DOE as a way to proceed quickly and efficiently through the RI/FS process at DOE facilities. Thus as its title implies, this guidance is intended to describe in detail the process and component elements of an RI/FS, as well as techniques to manage the RI/FS effectively.

  13. On the sequences ri, si, ti ∈ ℤ related to extended Euclidean algorithm and continued fractions

    Science.gov (United States)

    Muhammad, Khairun Nisak; Kamarulhaili, Hailiza

    2016-06-01

    The extended Euclidean Algorithm is a practical technique used in many cryptographic applications, where it computes the sequences ri, si, ti ∈ ℤ that always satisfy ri = si a+ tib. The integer ri is the remainder in the ith sequences. The sequences si and ti arising from the extended Euclidean algorithm are equal, up to sign, to the convergents of the continued fraction expansion of a/b. The values of (ri, si, ti) satisfy various properties which are used to solve the shortest vector problem in representing point multiplications in elliptic curves cryptography, namely the GLV (Gallant, Lambert & Vanstone) integer decomposition method and the ISD (integer sub decomposition) method. This paper is to extend the proof for each of the existing properties on (ri, si, ti). We also generate new properties which are relevant to the sequences ri, si, ti ∈ ℤ. The concepts of Euclidean algorithm, extended Euclidean algorithm and continued fractions are intertwined and the properties related to these concepts are proved. These properties together with the existing properties of the sequence (ri, si, ti) are regarded as part and parcel of the building blocks of a new generation of an efficient cryptographic protocol.

  14. Intrarenal resistance index (RI) as a predictor of early renal impairment in patients with liver cirrhosis.

    Science.gov (United States)

    Goyal, Sundeep; Dixit, V K; Jain, A K; Shukla, R C; Ghosh, Jayant; Kumar, Vinod

    2013-01-01

    Despite its functional nature, hepatorenal syndrome (HRS) is associated with a poor prognosis and the only effective treatment is liver transplantation. It is very important to diagnose renal impairment in cirrhosis patients at an early stage before overt HRS develops. In patients with cirrhosis the early renal impairment or renovascular vasoconstriction can be predicted by renal arterial resistance index (RI). Our study aimed to compare RI in healthy controls versus patients with liver cirrhosis with and without ascites and assess its value for predicting subsequent renal status. Patients were divided into 2 groups with 50 patients in each group. Group 1 contained patients with cirrhosis without ascites and group 2 contained cirrhosis patients with ascites. All patients were subjected to detailed clinical examination, laboratory investigations and abdominal doppler ultrasound with renal RI measurements. Patients were followed for 6 months. RI was significantly higher in cirrhotic patients as compared to healthy controls (0.62 vs. 0.52, pRI was significantly greater in patients with ascites than those without ascites (0.70 vs. 0.62, p RI >0.70 was significant independent predictor of subsequent HRS development (p = 0.006) CONCLUSIONS: Intrarenal RI measurement can be used as a predictor of HRS and may be further validated for regular monitoring of cirrhotic patients at risk of developing renal impairment.

  15. Yeast transformation mediated by Agrobacterium strains harboring an Ri plasmid: comparative study between GALLS of an Ri plasmid and virE of a Ti plasmid.

    Science.gov (United States)

    Kiyokawa, Kazuya; Yamamoto, Shinji; Sato, Yukari; Momota, Naoto; Tanaka, Katsuyuki; Moriguchi, Kazuki; Suzuki, Katsunori

    2012-07-01

    Agrobacterium strains containing a Ti plasmid can transfer T-DNA not only to plants but also to fungi, including the yeast Saccharomyces cerevisiae. However, no Agrobacterium strain harboring an Ri plasmid has been evaluated in fungal transformation. Some Ri plasmids have GALLS , instead of virE1 and virE2. GALLS protein can functionally substitute in plant transformation for a structurally different protein VirE2. In this study, we compared the yeast transformation ability among Agrobacterium donors: a strain containing a Ti plasmid, strains harboring either an agropine-type or a mikimopine-type Ri plasmid, and a strain having a modified Ri plasmid supplemented with a Ti plasmid type virE operon. Agrobacterium strains possessing GALLS transformed yeast cells far less efficiently than the strain containing virE operon. Production of GALLS in recipient yeast cells improved the yeast transformation mediated by an Agrobacterium strain lacking neither GALLS nor virE operon. A reporter assay to detect mobilization of the proteins fused with Cre recombinase revealed that VirE2 protein is much more abundant in yeast cells than GALLS. Based on these results, we concluded that the low yeast transformability mediated by Agrobacterium strains having the Ri plasmid is because of low amount of mobilized GALLS in yeast cells. © 2012 The Authors Journal compilation © 2012 by the Molecular Biology Society of Japan/Blackwell Publishing Ltd.

  16. Effect of nanoparticles on the RII -RI -RV rotator phase transitions of alkanes

    Science.gov (United States)

    Mukherjee, Prabir K.

    2017-08-01

    Experimental studies have shown that nanoparticles play an important role on the rotator phase transitions of n-alkanes. A phenomenological model for predicting the RII -RI -RV phase transitions in mixtures of alkanes and nanoparticles has been proposed by combining Flory-Huggins free energy of isotropic mixing and Landau free energy. The impact of nanoparticles on the RII -RI -RV phase transitions and their transition temperatures is discussed by means of phenomenological theory. The possibility of the tricritical behavior of the RI -RV phase transition in the mixtures of alkanes and nanoparticles is discussed. The theoretical predictions are in good qualitative agreement with available experimental results.

  17. ri Arraku kunstil on kaalu / Eero Epner, Andreas Trossek

    Index Scriptorium Estoniae

    Epner, Eero, 1978-

    2006-01-01

    Katkendid vestlusest, mis ilmub "Ilmamaa" kirjastatud Jüri Arraku monograafias, on valinud Eero Epner. Jüri Arraku 70. sünnipäeva tähistavad näitused: gobeläänide näitus Estonia Talveaias 3. X-5. XI; ühisnäitus Pamela June Crookiga Draakoni galeriis 17.-21. X; "Salastatud tekstid" G-galeriis 9.-28. X; "Graafika aastatest 1964-1974" Hausi galeriis kuni 24. XI; "Tagasivaatav mees. Jüri Arraku varane looming" Kumus 26. X-11. II 2007; eksliibriste näitus Tallinna keskraamatukogu peamaja näitusesaalis 3.-27. XI

  18. Riñón fetal hiperecogénico

    Directory of Open Access Journals (Sweden)

    Sandalio Durán Álvarez

    2011-12-01

    Full Text Available El hallazgo de riñones fetales hiperecogénicos es un problema de gran preocupación médica y de ansiedad familiar, porque casi siempre traduce una enfermedad renal importante. Cuando la hiperecogenicidad se acompaña de oligohidramnios, la mayoría de las veces estamos enfrentando una enfermedad poliquística; cuando no existe oligohidramnios, el diagnóstico probable es difícil. El objetivo de este reporte es la presentación de un niño con enfermedad poliquística autosómico recesiva. En los exámenes realizados a la madre, durante el embarazo, se encontró hiperecogenia renal y oligohidramnios. Se describe la evolución clínica, ultrasonográfica y gammagráfica de su enfermedad. Se revisa brevemente la literatura con relación al tema.

  19. Rae vald ja Jüri elanikud sõdivad tehnopargi ohtliku tehase vastu / Mari Kodres

    Index Scriptorium Estoniae

    Kodres, Mari

    2008-01-01

    Ettevõte Stainless Surface Technology OÜ soovib rajada Jüri tehnoparki metallide hapetega töötlemise tehase. Rae valla ehitusameti juhataja Enno Harmipaiga hinnangul on probleem tehase ja elumajade ühine kanalisatsioon

  20. Kalev ammendas Jüri aleviku kogu veevaru vaevu kahe kuuga / Askur Alas

    Index Scriptorium Estoniae

    Alas, Askur, 1973-

    2003-01-01

    Suurenenud veetarbimise tõttu taotleb Jüri alevik veelimiidi neljakordistamist. Tallinn uurib võimalusi võtta joogivee reservveevaruna kasutusele Raku ja Männiku järvistu. Kaart: Tööstus kolib Rae valda

  1. Erkki-Sven Tüüri vioolakontsert "Illuminatio" / Igor Grašnek

    Index Scriptorium Estoniae

    Grašnek, Igor, 1958-

    2009-01-01

    Erkki-Sven Tüüri vioolakontserdist "Illuminatio", mis tuli Eestis esiettekandele 20. veebruaril Estonia kontserdisaalis ja mida esitasid vioolamängija Lars Anders Tomter ning ERSO Olari Eltsi dirigeerimisel

  2. Aiandusäri jahtumismärke ei ilmuta / Aive Herja

    Index Scriptorium Estoniae

    Herja, Aive

    2008-01-01

    Haljastus- ja aiandusäri praegu veel jahtumismärke ei ilmuta. Arvamust avaldavad aiandusettevõtete juhid. Lk. 28 intervjuu maastikuarhitektuurifirma Artes Terrae OÜ juhatuse liikme Sulev Nurmega "Sulev Nurme: maastikuarhitektuuri turg on kasvutrendis"

  3. Johan Kõpp ja Jüri Uluots - õpetaja ja õpilane / Peeter Järvelaid

    Index Scriptorium Estoniae

    Järvelaid, Peeter, 1957-

    2009-01-01

    Kunagise Laiuse kirikuõpetaja, Tartu Ülikooli rektori ja Eesti Evangeelse Luterliku Kiriku peapiiskopi Johan Kõpu õpetajaametist Pärnu Poeglaste Gümnaasiumis ja selle mõjust õpilastele professor Jüri Uluotsa saatuse valgusel

  4. What Happened at No Gun Ri?: The Challenge of Civilians on the Battlefield

    National Research Council Canada - National Science Library

    Kuehl, Dale

    2003-01-01

    .... This story prompted an investigation by the Department of the Army Inspector General that found evidence of war crimes inconclusive, but acknowledged that Americans killed Korean civilians in the vicinity of No Gun Ri...

  5. Wear diagnostics of industrial material using RI beams of {sup 7}Be and {sup 22}Na

    Energy Technology Data Exchange (ETDEWEB)

    Yoshida, Atsushi, E-mail: ayoshida@ribf.riken.jp [Nishina Center (RNC), RIKEN (Japan); Kambara, Tadashi; Nakao, Aiko [Nishina Center (RNC), RIKEN (Japan); Uemoto, Ryuji; Uno, Hiroyuki; Nagano, Akira [S.H.I. Examination and Inspection Ltd. (Japan); Yamaguchi, Hidetoshi; Nakao, Taro; Kahl, Daid [Center for Nuclear Study (CNS), University of Tokyo (Japan); Yanagisawa, Yoshiyuki; Kameda, Daisuke; Ohnishi, Tetsuya; Fukuda, Naoki; Kubo, Toshiyuki [Nishina Center (RNC), RIKEN (Japan)

    2013-12-15

    As a possible example of radioactive ion (RI) beams for industrial application, intense beams of {sup 7}Be and {sup 22}Na used for wear diagnostics of mechanical parts is considered. For wear diagnostics, radioactive nuclei which have appropriate long life-time such as from several weeks to a few years are applicable. As those nuclei are located near the stable line, an in-flight RI beam separator can provide intense RI beams with enough high energy for implantation in atmosphere. Beam studies were performed to evaluate the intensity, uniformity, and depth profile of the implanted RI. We could achieve peak activity of 1.3 and 0.08 (kBq/μm)/(1 pμA × 1 h irradiation) at 13 and 50 μm peak depth with 20 and 150 μm maximum depth from the surface of an aluminum sample for {sup 7}Be and {sup 22}Na, respectively.

  6. Rein Kruus, Jüri Loigu ja igavene perifeeria / Toomas Haug

    Index Scriptorium Estoniae

    Haug, Toomas, 1956-

    2003-01-01

    Kirjandusteadlane Rein Kruus (1957-1992). Ilmunud ka kogumikus: Haug, Toomas. Troojamäe tõotus. Tallinn : Eesti Keele Sihtasutus, 2004, lk. 9-23, pealk.: Rein Kruus, Jüri Loigu ja igavene perifeeria : kirjanduslikku noorusromantikat

  7. Complete and Assembled Genome Sequence of Lactobacillus plantarum RI-113 Isolated from Salami.

    Science.gov (United States)

    Inglin, Raffael C; Meile, Leo; Klumpp, Jochen; Stevens, Marc J A

    2017-04-20

    We present here the complete genome sequence of Lactobacillus plantarum RI-113, a strain isolated from salami, which was determined using single-molecule real-time sequencing. Copyright © 2017 Inglin et al.

  8. 75 FR 77664 - Ananke, Inc., Providence, RI; Notice of Affirmative Determination Regarding Application for...

    Science.gov (United States)

    2010-12-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Ananke, Inc., Providence, RI; Notice of Affirmative Determination Regarding Application for Reconsideration By application dated October 25, 2010, a worker requested...

  9. 76 FR 65211 - Steiff North America, Lincoln, RI; Notice of Affirmative Determination Regarding Application for...

    Science.gov (United States)

    2011-10-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Steiff North America, Lincoln, RI; Notice of Affirmative Determination Regarding Application for Reconsideration By application received September 26, 2011, a worker requested...

  10. Inhibitory effects of phloroglucinol derivatives isolated from Ecklonia stolonifera on Fc(epsilon)RI expression.

    Science.gov (United States)

    Shim, Sun-Yup; Choi, Jae-Sue; Byun, Dae-Seok

    2009-07-01

    Two bioactive phloroglucinol derivatives, dioxinodehydroeckol (DHE) and phlorofucofuroeckol A (PFF-A) were isolated from edible marine brown alga, Ecklonia stolonifera, and evaluated for effects on cell surface Fc(epsilon)RI expression in KU812F cells. DHE and PFF-A were found to reduce the cell surface expression, and total cellular protein and mRNA levels for the Fc(epsilon)RI alpha chain. Moreover, both compounds exerted inhibitory effects against the elevation of intracellular calcium concentration [Ca(2+)](i) and histamine release from anti-Fc(epsilon)RI alpha chain antibody (CRA-1)-stimulated cells. These inhibitory effects were stronger for PFF-A than for DHE. These results show that two phloroglucinol derivatives, DHE and PFF-A, may exert anti-allergic effects via the inhibition of Fc(epsilon)RI expression, calcium influx, and degranulation in basophils, and contributes to the pharmacological activities of marine brown alga, including E. stolonifera.

  11. Piiratud vastutusega äriühingu juhatuse liikme lojaalsuskohustus / Tuuve Tiivel

    Index Scriptorium Estoniae

    Tiivel, Tuuve, 1977-

    2001-01-01

    Huvide konfliktist aktsiaseltsi ja selle juhatuse liikme vahelise tehingu puhul, sellise tehingu kehtivusest, juhatuse liikme tasust, laenu- ja konkurentsikeelust ning konfidentsiaalsuskohustusest Eesti ja Ameerika Ühendriikide äriõiguses

  12. R.I. Officials, EPA Celebrate Successful Climate Showcase Communities Partnership

    Science.gov (United States)

    RI's Congressional delegation today joined the EPA, elected officials, & community leaders to celebrate innovative work accomplished by 4 Ocean State communities to reduce energy consumption & greenhouse gas emissions in municipal & residential buildings.

  13. Data of evolutionary structure change: 1DKEC-2RI4J [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available --TKTYF >HH ----GGGG > ATOM 2438...hain> 2RI4J VVYPWTQRFFEHFG >HH GGG ... 1DKEC HFDLS--HGSAQ > -- HH...LSSADAVMNNAK re> HHHHH HHucture...entryIDChain> FWGKV--KVDEV >HH -- HHHH>

  14. Insights on copper coordination and reactivity of endonuclease EcoRI by ESR spectroscopy and modeling

    Science.gov (United States)

    Ji, Ming

    2009-03-01

    The cleavage of DNA by restriction endonuclease EcoRI is catalyzed by metal ions such as Mg^2+. However, Cu^2+ does not catalyze the cleavage of DNA by EcoRI. In order to understand the functional difference between Cu^2+ and Mg^2+, coordination of Cu^2+ in the EcoRI--DNA complex was clarified by ESR and MD simulation. There are two Cu^2+ components in the specific EcoRI-DNA complex. Each component has one N atom from histidine imidazole and one oxygen atom from the phosphate backbone of DNA coordinate to Cu^2+ based on the ESR experimental results. MD simulation further confirmed that the Nδ atom of His114 imidazole and one oxygen atom from the phosphate backbone of DNA coordinate to Cu^2+. Difference in the coordination of Cu^2+ and Mg^2+ explains their different functional behaviors.

  15. Abilinnapea Ratas pidas uputust paratamatuseks / Jüri Ratas ; interv. Piret Reiljan

    Index Scriptorium Estoniae

    Ratas, Jüri, 1978-

    2004-01-01

    Tallinna abilinnapea Jüri Ratas kommenteerib olukorda linnas, kus kahe päevaga sadas maha rohkem kui juulikuu sademete norm ette näeb. Vt. samas Meelis Eldermann. Miks veevärk vihmaga toime ei tulnud?

  16. Recent developments and research projects at the low-energy RI beam facility CRIB

    Energy Technology Data Exchange (ETDEWEB)

    Yamaguchi, H., E-mail: yamag@cns.s.u-tokyo.ac.jp [Center for Nuclear Study (CNS), University of Tokyo, RIKEN Campus, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Kahl, D.; Nakao, T. [Center for Nuclear Study (CNS), University of Tokyo, RIKEN Campus, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Wakabayashi, Y.; Kubono, S. [RIKEN Nishina Center, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Hashimoto, T. [Research Center for Nuclear Physics, Osaka University, 10-1 Mihogaoka, Ibaraki, Osaka 567-0047 (Japan); Hayakawa, S. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, 95125 Catania (Italy); Kawabata, T. [Department of Physics, Kyoto University, Kita-Shirakawa, Kyoto 606-8502,Japan (Japan); Iwasa, N. [Department of Physics, Tohoku University, Aoba, Sendai, Miyagi 980-8578 (Japan); Teranishi, T. [Department of Physics, Kyushu University, 6-10-1 Hakozaki, Fukuoka 812-8581 (Japan); Kwon, Y.K. [Institute for Basic Science, 70, Yuseong-daero 1689-gil, Yuseong-gu, Daejeon 305-811 (Korea, Republic of); Binh, D.N.; Khiem, L.H.; Duy, N.N. [Institute of Physics, Vietnam Academy of Science and Technology, 18 Hong Quoc Viet, Nghia do, HaNoi (Viet Nam)

    2013-12-15

    Highlights: • CRIB is a unique low-energy RI beam separator of the University of Tokyo. • CRIB has been produced various RI beams mainly on the proton-rich side. • The major topics studied at CRIB are resonant scatterings and (alpha, p) reactions. • Strong alpha resonances were observed with {sup 7}Be + alpha resonant scattering. -- Abstract: CRIB (CNS Radioactive Ion Beam separator) is a low-energy RI beam separator at the Center for Nuclear Study (CNS) of the University of Tokyo. An overview of the recent developments and status of CRIB, including a detailed summary of beam parameters, is presented. Studies on proton and α resonant scatterings, direct measurements of (α,p) reactions, and other types of measurements (β-decay lifetimes, etc.) have been performed using RI beams at CRIB, motivated by interests in astrophysical reactions and exotic nuclear structure. Among the studies at CRIB, the measurement of {sup 7}Be + α resonant scattering is discussed.

  17. Immunoglobulin A: Fc(alpha)RI interactions induce neutrophil migration through release of leukotriene B4.

    Science.gov (United States)

    van der Steen, Lydia; Tuk, Cornelis W; Bakema, Jantine E; Kooij, Gijs; Reijerkerk, Arie; Vidarsson, Gestur; Bouma, Gerd; Kraal, Georg; de Vries, Helga E; Beelen, Robert H J; van Egmond, Marjolein

    2009-12-01

    Exacerbations of ulcerative colitis (UC) are dominated by massive neutrophil influx in the lamina propria with concomitant mucosal ulceration. The prevalent antibody in this area is immunoglobulin A (IgA). Interestingly, the IgA Fc receptor (Fc(alpha)RI) potently activates neutrophils. As such, we investigated whether IgA-Fc(alpha)RI interaction contributes to tissue damage in UC. Response of neutrophils to bovine serum albumin-, IgG-, or IgA-coated beads and Escherichia coli was investigated with 3-dimensional culture systems, real-time video microscopy, and (fluorescence) microscopy. In vivo studies were performed using human Fc(alpha)RI transgenic mice or nontransgenic littermates. Microscopic slides of UC patients were stained for IgA, Fc(alpha)RI, and neutrophils. In vitro and in vivo cross-linking of Fc(alpha)RI on neutrophils by serum IgA or uptake of IgA-coated E coli led to neutrophil migration. The responsible chemotactic factor was identified as leukotriene B4. Moreover, dimeric IgA (dIgA), which is produced in the lamina propria, but neither secretory IgA nor IgG, was equally capable of inducing neutrophil recruitment. We furthermore showed that Fc(alpha)RI(+)-neutrophils in the colon of UC patients had phagocytosed IgA-antigen complexes. Neutrophils are the first cells that arrive at inflammatory sites once pathogens have crossed the epithelial barrier. Fc(alpha)RI-dIgA interactions therefore may constitute an essential activation step to recruit more neutrophils, hereby eradicating impending infections. However, excessive IgA-antigen complexes can sustain a perpetuating inflammatory loop in UC, hereby seriously aggravating morbidity. Novel therapeutic strategies that block dIgA-Fc(alpha)RI interactions, and therefore diminish neutrophil migration and activation, may dampen the uncontrolled inflammatory processes in these patients.

  18. Effects of extracorporeal shockwave lithotripsy on renal vasculature and renal resistive index (RI).

    Science.gov (United States)

    Hiros, Mustafa; Selimovic, Mirsad; Spahovic, Hajrudin; Sadovic, Sabina

    2009-01-01

    It is known that ESWL can promote acute renal injuries and long-term complications of renal vasculature. Effects on renal vasculature can be evaluated by color Doppler ultrasonography measuring renal resistive index (RI). This prospective study aimed to determine the influence of number of delivered SW-s, used kV and changes in renal resistive index. Total of 60 normotensive patients, 38 males (63%) and 22 females (37%), with renal stones 6-18 mm in size were included in this study. Median age was 42.3 years (range 22-55). RI was measured at interlobar artery before, 1, 3, 5 and 30 days after treatment on treated and contra lateral non-treated kidney. Patients were divided in two groups: Group I (N=25) received 2000 SWs; 0-2 units; (0.5 unit each 500 SWs) Group II (N=35) received 4000 SWs, 0-4 units; (0.5 unit each 500 SWs). In treated kidneys RI significantly increased first and second day after treatment from 0.62 +/- 0.05 at baseline to 0.67 +/- 0.05, p RI seven days after treatment is not significant (0.62 +/- 0.05). The contra lateral, non-treated kidney showed significant changes in RI only first day after treatment (0.64 +/- 0.05), p RI is on normal values in both kidneys. Resistive index-RI is important parameter in evaluation of renal vasculature. Patients treated by ESWL showed a temporary increase in RI two days after the treatment and only first day in contra lateral non-treated kidney--probably caused by release of substance with vasoconstriction properties (need further investigations).

  19. Functional Characteristics of the High Affinity IgG Receptor, Fc gamma RI

    NARCIS (Netherlands)

    van der Poel, Cees E.; Spaapen, Robbert M.; van de Winkel, Jan G. J.; Leusen, Jeanette H. W.

    2011-01-01

    IgG FcRs are important mediators of immunity and play a key role during Ab-based immunotherapy. Within the leukocyte IgG receptor family, only Fc gamma RI is capable of IgG binding with high affinity. Fc gamma RI exists as a complex of a ligand binding a-chain and an FcR gamma-chain. The receptors'

  20. President esines Jüri Gümnaasiumis kõnega / Juuli Laanemets

    Index Scriptorium Estoniae

    Laanemets, Juuli

    2010-01-01

    President Toomas Hendrik Ilves külastas 31. märtsil 2010 Rae valla Jüri Gümnaasiumi ning andis kooli ajaloo nädala raames tunni abiturientidele. Riigipea kohtus ka Rae vallavanema Veigo Gutmanni ja volikogu esimehe Agu Laiusega ning külastas ettevõtet UVIC AS. Tsitaat riigipea esinemisest Jüri Gümnaasiumis ilmunud ka: Hiiu Leht 6. apr. 2010, lk. 2

  1. Fast, accurate evaluation of exact exchange: The occ-RI-K algorithm.

    Science.gov (United States)

    Manzer, Samuel; Horn, Paul R; Mardirossian, Narbe; Head-Gordon, Martin

    2015-07-14

    Construction of the exact exchange matrix, K, is typically the rate-determining step in hybrid density functional theory, and therefore, new approaches with increased efficiency are highly desirable. We present a framework with potential for greatly improved efficiency by computing a compressed exchange matrix that yields the exact exchange energy, gradient, and direct inversion of the iterative subspace (DIIS) error vector. The compressed exchange matrix is constructed with one index in the compact molecular orbital basis and the other index in the full atomic orbital basis. To illustrate the advantages, we present a practical algorithm that uses this framework in conjunction with the resolution of the identity (RI) approximation. We demonstrate that convergence using this method, referred to hereafter as occupied orbital RI-K (occ-RI-K), in combination with the DIIS algorithm is well-behaved, that the accuracy of computed energetics is excellent (identical to conventional RI-K), and that significant speedups can be obtained over existing integral-direct and RI-K methods. For a 4400 basis function C68H22 hydrogen-terminated graphene fragment, our algorithm yields a 14× speedup over the conventional algorithm and a speedup of 3.3× over RI-K.

  2. Competency remodelling and application plans for development of job competency in RI-biomics

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Woo Ho; Park, Tai Jin [Korean Association for Radiation Application, Seoul (Korea, Republic of)

    2017-03-15

    RI-Biomics technology is advanced convergence technologies that can be measured in real time and track in vivo behavior and metabolism of substances using characteristics of the radioactive isotope. Its application fields are increasing such as drug development, agriculture, development of new materials and their utilization, etc. In addition, according to domestic and international developments and changes in the RI-Biomics environment, RI-Biomics professionals are needed to train continuously. To develop systematic human resources basement and competency-based curriculum, we perform competency modeling of pedagogical perspective to targeted at high-performance on RI-Biomics. Furthermore, we redefine the competency model and verified by industry experts with focus group interviews. In the result, two general competencies and three professional competencies were extracted by interview. Each competencies are organized six sub-competencies and nine sub-competencies. In the final steps, the same procedures were repeated to obtain the consensus of experts on derived competencies and behavioral objectives. The results of the study are applicable to enhance human resource management and to develop the curriculum for RI-Biomics expert training. It is expected to be used as reference material of long term-planning for RI-Biomics professional.

  3. A comparison of the structural requirements for DNA cleavage by the isoschizomers HaeIII, BspRI and BsuRI.

    Science.gov (United States)

    Wolfes, H; Fliess, A; Pingoud, A

    1985-07-01

    We have investigated the structural requirements for DNA cleavage by the isoschizomers HaeIII, BspRI and BsuRI which recognize the sequence -d(GGCC)-. For this purpose decadeoxynucleotides were synthesized by the solid-phase phosphotriester method and purified by high-performance liquid chromatography. The kinetics of cleavage of these oligodeoxynucleotides were determined for the three isoschizomers with the following results. The sequence adjacent to the recognition site strongly influences the rate of cleavage. The preference is qualitatively the same for all three enzymes: AGGCCT greater than TGGCCA greater than GGGCCC approximately equal to CGGCCG, and follows the thermal stability of the different decanucleotides. Substitutions within the recognition site, namely dI for dG and dU for dC, affect the rate of cleavage differently for the three enzymes. The results can be rationalized in terms of an interaction of HaeIII with the major and minor groove of the DNA, of BspRI mainly with the minor groove and of BsuRI with the major groove of DNA. It is obvious from our data that the mechanism of recognition of the same site is different for the three isoschizomers.

  4. ri Pihl : märatsemiste kõrgpunkt on möödas / Jüri Pihl ; interv. Lemmi Kann

    Index Scriptorium Estoniae

    Pihl, Jüri, 1954-

    2007-01-01

    Siseminister Jüri Pihl Tallinna rahutuste organiseeritusest, kurjategijate kinnipidamisest ja karistamisest ning edaspidistest turvameetmetest. Vt. samas: Piret Reiljan. Savisaar: valitsus ajab valet poliitikat; Pronkssõdur pannakse taas püsti enne 9. maid; Sten-Aleks Pihlak. Veebileht aitab kurjategijaid leida

  5. Examination of pattern of RI accumulation in thyroid cartilage on bone scintigraphy.

    Science.gov (United States)

    Kurooka, Hiroko; Kawabe, Joji; Tsumoto, Chikako; Hayashi, Takehiro; Oe, Ai; Kotani, Jin; Higashiyama, Shigeaki; Kawamura, Etsushi; Yamane, Hideo; Shiomi, Susumu

    2009-01-01

    In bone scintigraphy, abnormal RI accumulation in ossified thyroid cartilage is often noted. However, because similar accumulation is also seen in tumor-involved cartilage, distinction between these two lesions is sometimes difficult. We examined the differences in RI accumulation by ossification of the thyroid cartilage and cartilage invasion with anterior, posterior, and oblique views of bone scintigraphy in this study. This study included 120 patients (104 men, 16 women; mean age 67.8 +/- 9.6 years; range 48-90 years) with laryngeal or lower pharyngeal carcinoma. The patients had exhibited abnormal accumulation of RI on thyroid cartilage on bone scintigraphy between February 1999 and March 2007. We evaluated accumulation of thyroid cartilage in the anterior, posterior, and oblique views on bone scintigraphy. The presence/absence of tumor invasion of the thyroid cartilage was checked by comparing the findings of enhanced computed tomography and magnetic resonance imaging (MRI) as well as evaluating operative records. RI accumulation in thyroid cartilage was divided into four types (diffuse accumulation, intense diffuse accumulation, slight inhomogeneous accumulation, and intense inhomogeneous accumulation). Tumor invasion of thyroid cartilage was noted in 2 of the 42 patients with diffuse accumulation, 1 of the 18 patients with intense diffuse accumulation, 1 of the 38 patients with slight inhomogeneous accumulation, and 17 of 22 patients with intense inhomogeneous accumulation. Because the degree of tumor invasion was highest in cases in which bone scintigraphy revealed intense inhomogeneous accumulation of RI in the thyroid cartilage, we judged this pattern of RI accumulation to be an indicator of tumor invasion. When diagnosis was based on this criterion, positive predictive value, negative predictive value, and accuracy were 77%, 96%, and 93%, respectively (P RI accumulation in the thyroid cartilage in patients with head/neck cancer.

  6. Role of thymidine residues in DNA recognition by the EcoRI and EcoRV restriction endonucleases.

    Science.gov (United States)

    Fliess, A; Wolfes, H; Rosenthal, A; Schwellnus, K; Blöcker, H; Frank, R; Pingoud, A

    1986-04-25

    We have synthesized a series of oligonucleotides containing the EcoRI (GAATTC) or EcoRV (GATATC) recognition site within which or adjacent to which thymidine was substituted by uridine or derivatives of uridine. The effects of these substitutions on the rate of the EcoRI and EcoRV catalyzed cleavage reaction were investigated. Our results show that most of the substitutions within the site are quite well tolerated by EcoRI, not, however, by EcoRV. We conclude that the thymin residues most likely are not directly involved in the recognition process of the EcoRI reaction. In contrast, they are major points of contact, between substrate and enzyme in the EcoRV reaction. The effects of substitutions in the position adjacent to the recognition site is also markedly different for EcoRI and EcoRV. Here, EcoRI seems to be considerably more selective than EcoRV.

  7. Development of a Bayesian Belief Network Runway Incursion and Excursion Model

    Science.gov (United States)

    Green, Lawrence L.

    2014-01-01

    In a previous work, a statistical analysis of runway incursion (RI) event data was conducted to ascertain the relevance of this data to the top ten Technical Challenges (TC) of the National Aeronautics and Space Administration (NASA) Aviation Safety Program (AvSP). The study revealed connections to several of the AvSP top ten TC and identified numerous primary causes and contributing factors of RI events. The statistical analysis served as the basis for developing a system-level Bayesian Belief Network (BBN) model for RI events, also previously reported. Through literature searches and data analysis, this RI event network has now been extended to also model runway excursion (RE) events. These RI and RE event networks have been further modified and vetted by a Subject Matter Expert (SME) panel. The combined system-level BBN model will allow NASA to generically model the causes of RI and RE events and to assess the effectiveness of technology products being developed under NASA funding. These products are intended to reduce the frequency of runway safety incidents/accidents, and to improve runway safety in general. The development and structure of the BBN for both RI and RE events are documented in this paper.

  8. Endogenous IL-1 in cognitive function and anxiety: a study in IL-1RI-/- mice.

    Directory of Open Access Journals (Sweden)

    Carol L Murray

    Full Text Available Interleukin-1 (IL-1 is a key pro-inflammatory cytokine, produced predominantly by peripheral immune cells but also by glia and some neuronal populations within the brain. Its signalling is mediated via the binding of IL-1α or IL-1β to the interleukin-1 type one receptor (IL-1RI. IL-1 plays a key role in inflammation-induced sickness behaviour, resulting in depressed locomotor activity, decreased exploration, reduced food and water intake and acute cognitive deficits. Conversely, IL-1 has also been suggested to facilitate hippocampal-dependent learning and memory: IL-1RI(-/- mice have been reported to show deficits on tasks of visuospatial learning and memory. We sought to investigate whether there is a generalised hippocampal deficit in IL-1RI(-/- animals. Therefore, in the current study we compared wildtype (WT mice to IL-1RI(-/- mice using a variety of hippocampal-dependent learning and memory tasks, as well as tests of anxiety and locomotor activity. We found no difference in performance of the IL-1RI(-/- mice compared to WT mice in a T-maze working memory task. In addition, the IL-1RI(-/- mice showed normal learning in various spatial reference memory tasks including the Y-maze and Morris mater maze, although there was a subtle deficit in choice behaviour in a spatial discrimination, beacon watermaze task. IL-1RI(-/- mice also showed normal memory for visuospatial context in the contextual fear conditioning paradigm. In the open field, IL-1RI(-/- mice showed a significant increase in distance travelled and rearing behaviour compared to the WT mice and in the elevated plus-maze spent more time in the open arms than did the WT animals. The data suggest that, contrary to prior studies, IL-1RI(-/- mice are not robustly impaired on hippocampal-dependent memory and learning but do display open field hyperactivity and decreased anxiety compared to WT mice. The results argue for a careful evaluation of the roles of endogenous IL-1 in hippocampal

  9. AHP 10: "I, Ya ri a bsod, Am a Dog": The Life and Music of a Tibetan Mendicant Singer

    Directory of Open Access Journals (Sweden)

    Skal dbang skyid སྐལ་དབང་སྐྱིད།

    2011-06-01

    Full Text Available The life and music of Ya ri A bsod, a Tibetan composer and singer who lived in the early twentieth century, is described. Ya ri A bsod wandered through Tibetan nomad areas where contemporary Qinghai, Gansu, and Sichuan provinces meet in China. Texts and transcribed melodies of Ya ri A bsod songs are presented. These songs are contextualized in terms of their contemporary transmission, and the historical and autobiographical circumstances of their composition.

  10. Quantitative studies of the morphology of the south Poland using Relief Index (RI

    Directory of Open Access Journals (Sweden)

    Szypuła Bartłomiej

    2017-10-01

    Full Text Available The aim of this study was to introduce a new morphometric index named Relief Index (RI. RI is the ratio of the total length of the contour lines and the surface area at which they occur. This easily calculated index provides an objective quantitative measure of relief variability as an important feature in geomorphological studies. To achieve this goal, a highly detailed morphometric analysis was carried out using a high-resolution (1m×1m DEM. Twenty one sample areas in southern Poland were examined. These analyses showed RI, as a good tool for rapidly evaluating topography heterogeneity in division into relief classes. I distinguished 4 classes of the Relief Index that classify earth surface considering the variability of the relief. Results of the calculations demonstrated that there is a significant correlation between RI and the local relief and slopes, but there is no correlation between RI and planar curvatures and TWI. The relief of the sample areas were analysed using geomorphometric parameters (slopes, local relief, planar curvatures. Moreover the influence of the DEM resolution on Relief Index values was examined.

  11. RI-MP2 Gradient Calculation of Large Molecules Using the Fragment Molecular Orbital Method.

    Science.gov (United States)

    Ishikawa, Takeshi; Kuwata, Kazuo

    2012-02-02

    The second-order Møller-Plesset perturbation theory (MP2) gradient using resolution of the identity approximation (RI-MP2 gradient) was combined with the fragment molecular orbital (FMO) method to evaluate the gradient including electron correlation for large molecules. In this study, we adopted a direct implementation of the RI-MP2 gradient, in which a characteristic feature of the FMO scheme was utilized. Test calculations with a small peptide presented a computational advantage of the RI-MP2 gradient over the canonical MP2 gradient. In addition, it was shown that the error of the RI-MP2 gradient, caused by RI approximation, was negligible. As an illustrative example, we performed gradient calculations for two biomolecules-a prion protein with GN8 and a human immunodeficiency virus type 1 (HIV1) protease with lopinavir (LPV). These calculations demonstrated that the gradient including the correlation effect could be evaluated with only about twice the computational effort of the Hartree-Fock (HF) gradient.

  12. In-flight RI beam separator BigRIPS at RIKEN and elsewhere in Japan

    CERN Document Server

    Kubo, T

    2003-01-01

    Presented are features of the in-flight radioactive isotope (RI) beam separators in Japan as well as of a next-generation separator BigRIPS being built at RIKEN for the RI-beam factory project. Characteristic features and present status of the existing separators are reviewed for the RIPS at RIKEN, the Secondary Beam Line at RCNP, the Secondary Beam Course at NIRS, the CRIB at CNS and the RMS at JAERI. Design features are outlined for the BigRIPS, which is characterized by two major features: large acceptances and a tandem (or two-stage) separator scheme. The large acceptances allow one to produce RI beams efficiently by using in-flight fission of uranium ions, being achieved by using superconducting quadrupoles with a large aperture. The tandem separator scheme allows one to deliver tagged RI beam. The integrated capability of the BigRIPS and the accelerators of the project can significantly enlarge the scope of future RI-beam experiments. A low-energy course following the BigRIPS can provide energy-degraded...

  13. Insights on the Structural Details of Endonuclease EcoRI-DNA Complexes by Electron Spin Resonance

    Science.gov (United States)

    Sarver, Jessica

    2009-03-01

    Pulsed electron spin resonance (ESR) was used to probe the binding specificity of EcoRI, a restriction endonuclease. Using site-directed spin labeling, a nitroxide side chain was incorporated into the protein, enabling the use of ESR to study structural details of EcoRI. Distance measurements were performed on EcoRI mutants when bound to varying sequences of DNA using the Double Electron-Electron Resonance experiment. These distances demonstrated that the average structure in the arm regions of EcoRI, thought to play a major role in binding specificity, is the same when the protein binds to different sequences of DNA. Also, it was determined that the arms exhibit higher flexibility when bound to sequences other than the specific sequence due to the larger distance distributions acquired from these spin labeled complexes. Molecular dynamics (MD) simulations were performed on the spin-label-modified specific EcoRI-DNA crystal structure to model the average nitroxide orientation. The distance distributions from MD were found to be narrower than experiment, indicating the need for a more rigorous sampling of the nitroxide conformers in silico.

  14. BspRI restriction endonuclease: cloning, expression in Escherichia coli and sequential cleavage mechanism.

    Science.gov (United States)

    Raskó, Tamás; Dér, András; Klement, Eva; Slaska-Kiss, Krystyna; Pósfai, Eszter; Medzihradszky, Katalin F; Marshak, Daniel R; Roberts, Richard J; Kiss, Antal

    2010-11-01

    The GGCC-specific restriction endonuclease BspRI is one of the few Type IIP restriction endonucleases, which were suggested to be a monomer. Amino acid sequence information obtained by Edman sequencing and mass spectrometry analysis was used to clone the gene encoding BspRI. The bspRIR gene is located adjacently to the gene of the cognate modification methyltransferase and encodes a 304 aa protein. Expression of the bspRIR gene in Escherichia coli was dependent on the replacement of the native TTG initiation codon with an ATG codon, explaining previous failures in cloning the gene using functional selection. A plasmid containing a single BspRI recognition site was used to analyze kinetically nicking and second-strand cleavage under steady-state conditions. Cleavage of the supercoiled plasmid went through a relaxed intermediate indicating sequential hydrolysis of the two strands. Results of the kinetic analysis of the first- and second-strand cleavage are consistent with cutting the double-stranded substrate site in two independent binding events. A database search identified eight putative restriction-modification systems in which the predicted endonucleases as well as the methyltransferases share high sequence similarity with the corresponding protein of the BspRI system. BspRI and the related putative restriction endonucleases belong to the PD-(D/E)XK nuclease superfamily.

  15. Emdogain-regulated gene expression in palatal fibroblasts requires TGF-βRI kinase signaling.

    Directory of Open Access Journals (Sweden)

    Alexandra Stähli

    Full Text Available Genome-wide microarrays have suggested that Emdogain regulates TGF-β target genes in gingival and palatal fibroblasts. However, definitive support for this contention and the extent to which TGF-β signaling contributes to the effects of Emdogain has remained elusive. We therefore studied the role of the TGF-β receptor I (TGF-βRI kinase to mediate the effect of Emdogain on palatal fibroblasts. Palatal fibroblasts were exposed to Emdogain with and without the inhibitor for TGF-βRI kinase, SB431542. Emdogain caused 39 coding genes to be differentially expressed in palatal fibroblasts by microarray analysis (p10-fold. Importantly, in the presence of the TGF-βRI kinase inhibitor SB431542, Emdogain failed to cause any significant changes in gene expression. Consistent with this mechanism, three independent TGF-βRI kinase inhibitors and a TGF-β neutralizing antibody abrogated the increased expression of IL-11, a selected Emdogain target gene. The MAPK inhibitors SB203580 and U0126 lowered the impact of Emdogain on IL-11 expression. The data support that TGF-βRI kinase activity is necessary to mediate the effects of Emdogain on gene expression in vitro.

  16. Emdogain-regulated gene expression in palatal fibroblasts requires TGF-βRI kinase signaling.

    Science.gov (United States)

    Stähli, Alexandra; Bosshardt, Dieter; Sculean, Anton; Gruber, Reinhard

    2014-01-01

    Genome-wide microarrays have suggested that Emdogain regulates TGF-β target genes in gingival and palatal fibroblasts. However, definitive support for this contention and the extent to which TGF-β signaling contributes to the effects of Emdogain has remained elusive. We therefore studied the role of the TGF-β receptor I (TGF-βRI) kinase to mediate the effect of Emdogain on palatal fibroblasts. Palatal fibroblasts were exposed to Emdogain with and without the inhibitor for TGF-βRI kinase, SB431542. Emdogain caused 39 coding genes to be differentially expressed in palatal fibroblasts by microarray analysis (p10-fold). Importantly, in the presence of the TGF-βRI kinase inhibitor SB431542, Emdogain failed to cause any significant changes in gene expression. Consistent with this mechanism, three independent TGF-βRI kinase inhibitors and a TGF-β neutralizing antibody abrogated the increased expression of IL-11, a selected Emdogain target gene. The MAPK inhibitors SB203580 and U0126 lowered the impact of Emdogain on IL-11 expression. The data support that TGF-βRI kinase activity is necessary to mediate the effects of Emdogain on gene expression in vitro.

  17. The Fate of Integrated Ri T-DNA rol Genes during Regeneration via Somatic Embryogenesis in Tylophora indica

    Directory of Open Access Journals (Sweden)

    Dipasree Roychowdhury

    2015-01-01

    Full Text Available The fate of integrated Ri T-DNA rol genes during regeneration via indirect somatic embryogenesis and stability of its effect on morphology and tylophorine content of Ri-transformed plants have been studied in Tylophora indica. Integration and expression of Ri T-DNA genes in transformed embryogenic callus lines derived from transformed root lines, 300 Ri-transformed somatic embryos, and 23 Ri-transformed plant lines were analysed. Fifty root lines studied showed integration and expression of four rol genes of TL-DNA. Spontaneous regeneration via indirect somatic embryogenesis was obtained from root lines that were TL+/TR−. Stable integration and expression of rol genes were observed in root lines, embryogenic callus lines, and the spontaneously induced somatic embryos. Nineteen out of the 23 Ri-transformed plant lines and their clones showed phenotypic and genetic stability over the period of 3 years. Four Ri-transformed plants were morphologically similar to nontransformed plants but showed variation with the integration and expression of the rolA gene and absence of other rol genes. Variant Ri-transformed plant line A428#1-V showed highest tylophorine content (2.93±0.03 mg gDW−1 among plant lines studied. The effects of T-DNA genes on growth, morphology, and tylophorine content of the Ri-transformed plants were stable in the long term culture.

  18. ri Talvet Juhan Liivi radadel / Jüri Talvet on the Trails of Juhan Liiv

    Directory of Open Access Journals (Sweden)

    Tanar Kirs

    2016-12-01

    Full Text Available Teesid: Käesolev uurimus põhineb Jüri Talveti juubeliüritusel peetud ettekandel ning keskendub professori Liivi-alase tegevuse käsitlemisele. Artiklis tutvustan Talveti Liivi-tõlgenduse uudseid ja vähemärgatud detaile, mis kajastuvad tema koostatud Liivi luule väljaannetes ja nendega ühenduses olevates kriitilistes käsitlustes. Siinjuures tahan näidata, et Talvet avaldab Liivi luulet teistsuguses võtmes ja teisendab oluliselt seda normi, mille vahendusel Liivi luulet tänapäeval tuntakse.   The article addresses Jüri Talvet’s interpretation of poetry by Juhan Liiv (1864–1913. Its focus lies on a collection of Liiv’s poetry Snow Drifts, I Sing: Selected Poems (Lumi tuiskab, mina laulan: Valik luulet, 2013 compiled by Talvet. I shall compare this book with the most extensive volume of Liiv’s poetry of the previous century With and Without You (Sinuga ja sinuta, 1989 edited by Aarne Vinkel, which has had a major role in the shaping of the norms that serve as a basis for understanding Liiv’s work in recent times. The article observes how these volumes mediate Liiv’s poetry and the way Talvet transposes its earlier publishing standards. More particularly, I will analyse the poetry collection edited by Talvet from five perspectives: I will map the new texts and text fragments included in the work, discuss Talvet’s corrections and highlight the omitted fragments and full texts. Such specific treatment can be narrowed down to three broader topics: what new additions Talvet makes to the known textual body of Liiv’s poems (new texts; what changes he makes to previously published poems (textual additions, corrections and omissions; what he has left out (omitted texts. Talvet adds a great number of texts to the known body of Liiv’s poems. The poetry book Snow Drifts, I Sing contains over 20 poems that are not included in With and Without You; furthermore, Talvet publishes a number of new pieces of poetry. These texts have

  19. ri Talvet maailmaluule tõlgendajana / Jüri Talvet’s Interpretations of World Poetry

    Directory of Open Access Journals (Sweden)

    Lauri Pilter

    2016-12-01

    Full Text Available Teesid: Tartu Ülikooli maailmakirjanduse professori, luuletaja, kirjandusteadlase ja hispaaniakeelse kirjanduse spetsialisti Jüri Talveti tõlketegevuse viljade hulka kuulub luulet ja proosat nii sajandeid vanast Hispaania klassikast kui ka 20. sajandil või tänapäeval romaani keeltes või inglise keeles loodud teostest. Käesolev artikkel keskendub sellele, kuidas professor Talvet on tõlgendanud luule ja poeetika, kuid ka kirjandusajaloo, iseäranis barokk-kirjanduse alaseid küsimusi oma kirjandusteaduslikes esseedes. Vaadeldakse ka tema tõlketegevuse mahtu ja tõlketöö põhimõtteid.   Jüri Talvet (born in 1945 is a poet and a scholar of comparative literature, Chair Professor of World Literature at the University of Tartu. His numerous translations of poetry and poetical fiction from the Romance languages and, to a lesser extent, from English, reflect his views on world poetry. Those views are also expressed in his theoretical writings from the years of 1977 to 2015. Having studied English literature as the main subject at the University of Tartu, he early developed an interest in Spanish, in other Iberian languages, and in the Iberoamerican literatures. His translations from that area include works from medieval and early modern literature as well as notable literary achievements from the 20th century and the contemporary era. Talvet’s interpretations of Federico García Lorca and the “Latin American boom” authors are supported by profound insights into the philosophy, aesthetics, and poetics of the 17th century Spanish Baroque literature, known as the literary Golden Age of Spain. The influence which Talvet’s activities have exerted has widened the horizons of Estonia’s literary culture: while in the early 20th century, the previous German, Russian and Finnish leanings were supplemented by orientations to, and translations from, French and Italian literatures, Talvet has helped to enrich the Estonian literary landscape

  20. Schedule Optimization Study, Hanford RI/FS Program. Volume 2, Final report

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-01

    A Schedule Optimization Study (SOS) of the US Department of Energy (DOE) Hanford Site Remedial Investigation/Feasibility Study (RI/FS) Program was conducted by an independent team of professionals from other federal agencies and the private sector experienced in environmental restoration. This team spent two weeks at Hanford in September 1992 examining the reasons for the lengthy RI/FS process at Hanford and developing recommendations to expedite the process. The need for the study arose out of a schedule dispute regarding the submission of the 1100-EM-1 Operable Unit RI/FS Work Plan. This report documents the study called for in the August 29, 1991, Dispute Resolution Committee Decision Statement. Battelle`s Environmental Management Operations (EMO) coordinated the effort for DOE`s Richland Field Office (RL).

  1. The erudite humility of the historian: the 'critical epistemology' of Georges Lantéri-Laura.

    Science.gov (United States)

    Basso Lorini, Elisabetta

    2017-06-01

    This paper analyses the historical and epistemological work of the French psychiatrist Georges Lantéri-Laura (1930-2004) within the context of the French 'tradition' of history and philosophy of sciences, with special reference to Georges Canguilhem and Michel Foucault. After an introduction devoted to a critical survey of the most recent works on the history and historiography of psychiatry in French, the paper outlines Lantéri-Laura's approach by focusing especially on the role played by the methodological concept of 'semiology' as regards the relation between medicine and psychiatry. The last part of the paper draws attention to the relation between the history and philosophy of psychiatry in light of Lantéri-Laura's 'critical epistemology'.

  2. The value of RI scintigraphy and angiography in small intestinal bleeding; Report of eight cases

    Energy Technology Data Exchange (ETDEWEB)

    Kurosawa, Susumu; Kuwata, Hajime; Kushibiki, Kyoko; Akimoto, Kimihiko; Hashimoto, Toshiyuki; Kojima, Toshiya (Showa General Hospital, Kodaira, Tokyo (Japan))

    1991-07-01

    We retrospectively reviewed eight cases of small intestinal bleeding and assessed the value of RI scintigraphy and angiography in diagnosing the bleeding site. The patients' average age was 56.2 years. Chief complaint was melena of variable degree. In most cases neither upper endoscopy nor colonoscopy was diagnostic. RI scientigraphy (Tc-99 labeled human serum albumin) showed 75% of positive rate whereas angiography showed 66.7% (4/6) of positive rate. All four cases of leiomyosarcoma and leiomyoma demonstrated hypervascular stain and/or extra-vasation in angiography whereas RI scintigraphy failed to detect active gastrointestinal bleeding in 2 of the 4 cases. Therefore angiography was considered useful for the detection of bleeding from leiomyoma and leiomyosarcoma which are often hypervascular. Scintigraphy is thought of most value in the demonstration of small amount of bleeding with minimum vascular abnormality. (author).

  3. Development of RI-based real-time display technology of apoptotic cell death

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sang Hyun; Jagn, Beom Su; Hayu, Tyas Utami

    2012-01-15

    Apoptosis, or the programmed cell death, is the generally normal death of a cell in living organisms. Inappropriate apoptosis (either too little or too much) is a factor in many human disease including neurodegenerative diseases, autoimmune disorders and many types of cancer. Therefore, it is one of the most challenging and widely studied topics currently. Development of RI-based real-time display technology of apoptosis can be provided invaluable analysis data for diagnosis and treatment of various diseases. In this study, bifunctional chelator (BFC) for Tc-99m tricarbonyl was synthesized for ML-10 derivative radiolabeling. The formation of complexation of apoptotic cells was developed by combining the ML-10 moiety with the BFC for {sup 99m}Tc-tricarbonyl precursor. The results of this project will be utilized for the development of RI-Biomics Center-based Total Analysis System (TAS) through the optimization of equipment in the RI-Biomics Center.

  4. Yamaha esitles Venemaal elektritshellot Erkki-Sven Tüüri heliteosega

    Index Scriptorium Estoniae

    2002-01-01

    15. mail kõlas Moskva konservatooriumi suures saalis Erkki-Sven Tüüri "Tshellokontsert", elektritshellol soleeris David Geringas ja Vene Rahvusorkestrit juhatas Gintaras Rinkevicius. 28. mail tuleb ettekandele Birminghami Simphony Hallis E.-S. Tüüri "Aditus" ja "Viiulikontsert", solistiks Isabelle van Keulen ja dirigendiks Paavo Järvi. Järgnevalt toimub nimetatud teoste ja "Exoduse" plaadistamine firmale ECM. Zürichi ooperiteatris etendub ballett, kuhu on lülitatud neli pala E.-S. Tüürilt: "Insula deserta", "Searching for Roots", "Passion" ja "Crystallisatio"

  5. RFI/RI work plan for the Road A Chemical Basin 904-111G

    Energy Technology Data Exchange (ETDEWEB)

    Kmetz, T.F.

    2000-03-07

    This Resource Conservation and Recovery Act (RCRA) Facility Investigation (RFI)/Remedial Investigation (RI) Work Plan has been prepared for the Road A Chemical Basin Operable Unit (RdACB OU) (904-111G). This unit is subject to the requirements of both RCRA and the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). This Work Plan presents the initial evaluation of existing unit data, applicable background data, the regulatory framework for the unit investigation, and the evaluations and decisions made during the determination of the scope and objectives of the planned Remedial Investigation/Feasibility Study (RI/FS) activities.

  6. RiTE: Providing On-Demand Data for Right-Time Data Warehousing

    DEFF Research Database (Denmark)

    Thomsen, Christian; Pedersen, Torben Bach; Lehner, Wolfgang

    2008-01-01

    ). This is done using regular INSERT statements, resulting in too low insert speeds. There is thus a great need for a solution that makes inserted data available quickly, while still providing bulk-load insert speeds. This paper presents RiTE ("Right-Time ETL"), a middleware system that provides exactly that....... A data producer (ETL) can insert data that becomes available to data consumers on demand. RiTE includes an innovative main-memory based catalyst that provides fast storage and offers concurrency control. A number of policies controlling the bulk movement of data based on user requirements for persistency...

  7. Äriõigus 2006 : seaduste tekstid seisuga 01. 03. 2006 / koost. Andrus Lauren

    Index Scriptorium Estoniae

    2006-01-01

    Kaanel sisu: Äriseadustik. Tulundusühistuseadus. TsÜS. Euroopa äriühingu (SE) määrus. Euroopa äriühingu (SE) määruse RS. SE töötajate kaasamise seadus. Euroopa ühistu (SCE) määrus. Euroopa ühistu (SCE) määruse RS. EMHÜ määrus. EMHÜ määruse RS. Konkurentsiseadus. Majandustegevuse registri seadus. Väärtpaberite keskregistri seadus. - Kommentaarid lk. 256-276

  8. Sukupolvenvaihdoksen verosuunnittelu Autoväri Keijo Hirvonen Oy:ssä

    OpenAIRE

    Vauhkonen, Sanna

    2013-01-01

    Pretax Pohjois-Karjala Oy oli opinnäytetyön toimeksiantaja, jonka asiakasyritykselle Autoväri Keijo Hirvonen Oy:lle tehtiin opinnäytetyö. Sukupolvenvaihdos Autoväri Keijo Hirvonen Oy:ssä on tarkoitus toteuttaa kolmessa eri vaiheessa. Kaksi vaiheista on jo toteutettu ja viimeinen sukupolvenvaihdoksen vaihde ollaan toteuttamassa viiden vuoden sisällä. Opinnäytetyön tarkoituksena oli selvittää verotuksellisesti edullisin vastikkeeton suku-polvenvaihdoksen muoto. Opinnäytetyössä tutkittavia l...

  9. Emdogain-regulated gene expression in palatal fibroblasts requires TGF-βRI kinase signaling.

    OpenAIRE

    Stähli, Alexandra Beatrice; Bosshardt, Dieter; Sculean, Anton; Gruber, Reinhard

    2014-01-01

    Genome-wide microarrays have suggested that Emdogain regulates TGF-β target genes in gingival and palatal fibroblasts. However, definitive support for this contention and the extent to which TGF-β signaling contributes to the effects of Emdogain has remained elusive. We therefore studied the role of the TGF-β receptor I (TGF-βRI) kinase to mediate the effect of Emdogain on palatal fibroblasts. Palatal fibroblasts were exposed to Emdogain with and without the inhibitor for TGF-βRI kinase, SB43...

  10. Accuracy of the EcoRI restriction endonuclease: binding and cleavage studies with oligodeoxynucleotide substrates containing degenerate recognition sequences.

    Science.gov (United States)

    Thielking, V; Alves, J; Fliess, A; Maass, G; Pingoud, A

    1990-05-15

    We have synthesized a series of 18 nonpalindromic oligodeoxynucleotides that carry all possible base changes within the recognition sequence of EcoRI. These single strands can be combined with their complementary single strands to obtain all possible EcoRI sequences (left), or they can be combined with a single strand containing the canonical sequence to obtain double strands with all possible mismatches within the recognition sequence (right): (sequence; see text) The rate of phosphodiester bond cleavage of these oligodeoxynucleotides by EcoRI was determined in single-turnover experiments under normal buffer conditions in order to find out to what extent the canonical recognition site can be distorted and yet serve as a substrate for EcoRI. Our results show that oligodeoxynucleotides containing mismatch base pairs are in general more readily attacked by EcoRI than oligodeoxynucleotides containing EcoRI sites and that the rates of cleavage of the two complementary strands of degenerate oligodeoxynucleotides are quite different. We have also determined the affinities of these oligodeoxynucleotides to EcoRI. They are higher for oligodeoxynucleotides carrying a mismatch within the EcoRI recognition site than for oligodeoxynucleotides containing an EcoRI site but otherwise do not correlate with the rate with which these oligodeoxynucleotides are cleaved by EcoRI. Our results allow details to be given for the probability of EcoRI making mistakes in cleaving DNA not only in its recognition sequence but also in sequences closely related to it. Due to the fact that the rates of cleavage in the two strands of a degenerate sequence generally are widely different, these mistakes are most likely not occurring in vivo, since nicked intermediates can be repaired by DNA ligase.

  11. Bayesian network as a modelling tool for risk management in agriculture

    DEFF Research Database (Denmark)

    Rasmussen, Svend; Madsen, Anders L.; Lund, Mogens

    . In this paper we use Bayesian networks as an integrated modelling approach for representing uncertainty and analysing risk management in agriculture. It is shown how historical farm account data may be efficiently used to estimate conditional probabilities, which are the core elements in Bayesian network models....... We further show how the Bayesian network model RiBay is used for stochastic simulation of farm income, and we demonstrate how RiBay can be used to simulate risk management at the farm level. It is concluded that the key strength of a Bayesian network is the transparency of assumptions...

  12. Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in anaerobic bacteria.

    Science.gov (United States)

    Letzel, Anne-Catrin; Pidot, Sacha J; Hertweck, Christian

    2014-11-18

    Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a diverse group of biologically active bacterial molecules. Due to the conserved genomic arrangement of many of the genes involved in their synthesis, these secondary metabolite biosynthetic pathways can be predicted from genome sequence data. To date, however, despite the myriad of sequenced genomes covering many branches of the bacterial phylogenetic tree, such an analysis for a broader group of bacteria like anaerobes has not been attempted. We investigated a collection of 211 complete and published genomes, focusing on anaerobic bacteria, whose potential to encode RiPPs is relatively unknown. We showed that the presence of RiPP-genes is widespread among anaerobic representatives of the phyla Actinobacteria, Proteobacteria and Firmicutes and that, collectively, anaerobes possess the ability to synthesize a broad variety of different RiPP classes. More than 25% of anaerobes are capable of producing RiPPs either alone or in conjunction with other secondary metabolites, such as polyketides or non-ribosomal peptides. Amongst the analyzed genomes, several gene clusters encode uncharacterized RiPPs, whilst others show similarity with known RiPPs. These include a number of potential class II lanthipeptides; head-to-tail cyclized peptides and lactococcin 972-like RiPP. This study presents further evidence in support of anaerobic bacteria as an untapped natural products reservoir.

  13. 77 FR 73114 - Draft Written Re-Evaluation for Environmental Impact Statement: T.F. Green Airport, Warwick, RI

    Science.gov (United States)

    2012-12-07

    ... improvements at Theodore Francis Green Airport in Warwick, Rhode Island. The document will assist the FAA in... England, 16 New England Executive Park, Burlington, MA, 781- 238-7613; Warwick Central Library, 600 Sandy Lane, Warwick, RI, 401-739-5440; Warwick Library, Apponaug Branch, 3267 Post Road, Warwick, RI, 401...

  14. Tornide väljaku müüriäärse ala tulevik endiselt ebaselge / Askur Alas

    Index Scriptorium Estoniae

    Alas, Askur, 1973-

    2004-01-01

    Tallinna linna ja ehitusfirma Restor vaheline tüli linnamüüri äärse maa täisehitamise suhtes Suurtüki kvartalis pole lahendust leidnud. Linnaosavalitsus soovib müüri äärde parki ja tahab algatada ala detaiplaneeringut. Restoril on Plate ja Eppingi torni vahel ridaelamuboksid juba välja ehitatud

  15. 77 FR 71200 - Submission for Review: Initial Certification of Full-Time School Attendance, RI 25-41

    Science.gov (United States)

    2012-11-29

    ... MANAGEMENT Submission for Review: Initial Certification of Full-Time School Attendance, RI 25-41 AGENCY: U.S... Full-Time School Attendance. As required by the Paperwork Reduction Act of 1995, (Pub. L. 104-13, 44 U... to (202) 395-6974. SUPPLEMENTARY INFORMATION: RI 25-41, Initial Certification of Full-Time School...

  16. 76 FR 54810 - Submission for Review: 3206-0215, Verification of Full-Time School Attendance, RI 25-49

    Science.gov (United States)

    2011-09-02

    ... MANAGEMENT Submission for Review: 3206-0215, Verification of Full-Time School Attendance, RI 25-49 AGENCY: U..., Verification of Full-Time School Attendance. As required by the Paperwork Reduction Act of 1995 (Pub. L. 104-13... to (202) 395-6974. SUPPLEMENTARY INFORMATION: RI 25-49, Verification of Full-Time School Attendance...

  17. A comparative study of the FcepsilonRI molecule on human mast cell and basophil cell lines

    DEFF Research Database (Denmark)

    Jensen, Bettina Margrethe; Dissing, S; Skov, P S

    2005-01-01

    Mast cells and basophils express the high-affinity IgE receptor FcepsilonRI. We have analysed the human mast cell line LAD2 and four subclones of the basophil cell line KU812 in order to reveal possible differences concerning the FcepsilonRI surface regulation, anti-IgE-triggered activation, Fcep...

  18. A Complete Cleavage Map of Neurospora crassa mtDNA Obtained with Endonucleases Eco RI and Bam HI

    NARCIS (Netherlands)

    Terpstra, P.; Holtrop, M.

    1977-01-01

    A physical map of Neurospora crassa mitochondrial DNA has been constructed using specific fragments obtained with restriction endonucleases. The DNA has 5 cleavage sites for endonuclease Bam HI, 12 for endonuclease Eco RI and more than 30 for endonuclease Hind III. The sequence of the Eco RI and Bam

  19. Serine phosphorylation of FcγRI cytoplasmic domain directs lipid raft localization and interaction with protein 4.1G.

    Science.gov (United States)

    Gibson, Andrew W; Li, Xinrui; Wu, Jianming; Baskin, Julie G; Raman, Chander; Edberg, Jeffrey C; Kimberly, Robert P

    2012-01-01

    The high-affinity IgG receptor (CD64, FcγRI) has several special capacities, including the receptor-stimulated cleavage of the cell surface B cell-activating factor of the TNF superfamily (TNFSF13B). With the use of the yeast two-hybrid system, we and others have shown that FcγRI interacts with protein 4.1G (EPB41L2). Our mutational analyses identified two required 4.1G-interacting regions in the FcγRI CY and one FcγRI-interacting site in the C-terminus of protein 4.1G. Herein, we explore mechanism(s) that may regulate the interaction between protein 4.1G and FcγRI CY and influence FcγRI membrane mobility and function. We show that FcγRI CY interacts with protein 4.1G in vitro and that FcγRI coimmunoprecipitates protein 4.1G in freshly isolated human PBMC. With the use of immunostaining, we show that FcγRI colocalizes with protein 4.1G in unstimulated U937 cells, in which the FcγRI CY is constitutively serine-phosphorylated, but significant uncoupling occurs following FcγRI cross-linking, suggesting phosphoserine-regulated interaction. In vitro, protein 4.1G interacted preferentially with CK2-phosphorylated FcγRI CY, and compared with WT FcγRI, a nonphosphorylatable FcγRI mutant receptor was excluded from lipid rafts, suggesting a key role for protein 4.1G in targeting phosphorylated FcγRI to rafts. These data are consistent with a phosphoserine-dependent tethering role for protein 4.1G in maintaining FcγRI in lipid rafts and provide insight into the unique phosphoserine-based regulation of receptor signaling by FcγRI CY.

  20. Predictive Event Triggered Control based on Heuristic Dynamic Programming for Nonlinear Continuous Time Systems

    Science.gov (United States)

    2015-08-17

    Control based on Heuristic Dynamic Programming for Nonlinear Continuous-Time Systems In this paper, a novel predictive event-triggered control...method based on heuristic dynamic programming (HDP) algorithm is developed for nonlinear continuous-time systems. A model network is used to estimate...College Road, Suite II Kingston, RI 02881 -1967 ABSTRACT Predictive Event-Triggered Control based on Heuristic Dynamic Programming for Nonlinear

  1. Anti-ri-antibody-associated paraneoplastic syndrome in a man with breast cancer showing a reversible pontine lesion on MRI.

    Science.gov (United States)

    Kim, Heeyoung; Lim, Youngmin; Kim, Kwang-Kuk

    2009-09-01

    Paraneoplastic neurological disorders associated with anti-Ri-antibodies, which are typically present with opsoclonus-myoclonus-ataxia. Most cases with anti-Ri-antibodyassociated paraneoplastic syndrome due to breast cancer occur in women - its occurrence in men is extremely rare. We present herein the case of a male patient with breast cancer who had atypical anti-Ri-antibody-associated paraneoplastic syndrome presenting as complete horizontal ophthalmoplegia, left trigeminal sensory symptoms, and truncal ataxia. Following the diagnosis of paraneoplastic syndrome, chemotherapy and immunomodulating treatment including intravenous immunoglobulin and oral prednisolone were administered. Although the patient was negative for serum anti-Ri-antibodies 14 weeks later, his symptoms persisted. To our knowledge, this is the first case report of ophthalmoplegia without opsoclonus-myoclonus in a male anti-Ri-antibody-positive patient with breast cancer.

  2. Uudised : Tüüri Tshellokontsert Tokios. Robert Fripp tuleb Eestisse

    Index Scriptorium Estoniae

    2006-01-01

    Erkki-Sven Tüüri "Tshellokontserdi" esitusest 28. juunil Tokio Suntory Hallis ja 29. juunil Tokio Opera Hallis. Inglise rockkitarristi Robert Frippi kontsertidest 22. aug. Tallinna Pühavaimu kirikus, 23. aug. Pärnu Eliisabeti kirikus, 24. aug. Haapsalu Lossikirikus, 25. aug. Viljandi Jaani kirikus ja 26. aug. Tartu Jaani kirikus

  3. Tanel Saare omapärane duett Jüri Järvetiga / Tiiu Laks

    Index Scriptorium Estoniae

    Laks, Tiiu, 1984-

    2010-01-01

    VAT Teatri lavastusest "... viimane lint / Saare esimene lint", kus põimuvad Tanel Saare esitus ja Jüri Järvet vana Krappina ekraanil. Tanel Saar lindistab S. Becketti "Krappi viimase lindi" salvestatud osa, mille kuulamine taaslavastatakse 30 aasta pärast, kui T. Saar ise on juba vana Krappi eas

  4. Kahn : Vene nõuded on seotud tippkohtumisega / Jüri Kahn ; interv. Toomas Sildam

    Index Scriptorium Estoniae

    Kahn, Jüri, 1953-

    2002-01-01

    Aastatel 1992-1995 suursaadikuna Moskvas töötanud Jüri Kahn peab tõenäoliseks, et Venemaa asevälisministri Jevgeni Gussarovi Eestile esitatud nõudmised on presidentide Rüütli ja Putini võimaliku kohtumise Vene-poolne stsenaarium

  5. ÜRO peasekretäri Kofi Annani ähvardab tagandamine / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2004-01-01

    Väidetavalt on Iraagi toiduabiprogrammi raha saanud Iraagi toonane president Saddam Hussein ja Iraagi naftatehingutega seotud ärimehed, afääris on osalenud ÜRO peasekretäri Kofi Annani poeg Kojo. Lisa: Kofi Annan

  6. ri ja Pärnu panid kunstis seljad kokku / Kaarel Aluoja

    Index Scriptorium Estoniae

    Aluoja, Kaarel

    2000-01-01

    Pärnus Chaplini keskuses avati Türi kunstnike näitus, kus esinevad: Ülle Kuldkepp nahktaiestega, Resa Tiitsmaa tekstiilskulptuuridega, Kärt Putk joonistustega, Eve Sambla raamatuköidetaga, Priit Pajos ja Margus Sorge Tiitsmaa õlimaalidega ja Indrek Tegelmann joonistustega; Mark Soosaare kommentaar

  7. Puiduäri ajajad said Venemaal tüssata / Väinu Rozental

    Index Scriptorium Estoniae

    Rozental, Väinu, 1957-

    2008-01-01

    Tartumaal Rõngus asuva puidutöötlemisfirma ASi KR Priit omanikud alustasid kolm aastat tagasi koos ammuse tuttavaga Venemaa ühist äri, kuid said hoopis partnerilt häbematult petta. Lisatud: Vene toll ajab käed sissevedaja taskusse ; kronoloogia ning vandeadvokaadi Aivar Pilvi kommentaar

  8. Measuring and Monitoring in the South African "Kha Ri Gude" Mass Literacy Campaign

    Science.gov (United States)

    McKay, Veronica

    2015-01-01

    After many previous failed attempts to reach illiterate adults, the award-winning South African "Kha Ri Gude" mass literacy campaign, launched in 2008, undertook to ensure that learners seized the opportunity to learn--for many adults, this was a "last chance". Written from an insider perspective by the campaign's founding…

  9. Genealogy of gas cells for low-energy RI-beam production

    Energy Technology Data Exchange (ETDEWEB)

    Wada, Michiharu, E-mail: mw@riken.jp

    2013-12-15

    Highlights: • In order to overcome serious limitations in the universality of the traditional isotope separator on-line technique, various endeavors have been made on gas catcher cells for converting relativistic RI-beams from in-flight separators to low-energy RI-beams. • The origin of the gas catcher is found in the IGISOL (Ion guide isotope separator on-line) technique. • Many developments have been made over the years to overcome the various difficulties and drawbacks found in the IGISOL technique. -- Abstract: In order to overcome serious limitations in the universality of the traditional isotope separator on-line technique, various endeavors have been made on gas catcher cells for converting relativistic RI-beams from in-flight separators to low-energy RI-beams. The origin of the gas catcher is found in the IGISOL (Ion guide isotope separator on-line) technique. Many developments have been made over the years to overcome the various difficulties and drawbacks found in the IGISOL technique.

  10. Haud nr. 7583 / Alla Demidova ; tõlkinud Jüri Ojamaa

    Index Scriptorium Estoniae

    Demidova, Alla

    1993-01-01

    Näitlejanna meenutab oma koostööd režissöör A.Tarkovskiga ja režissööri hauaplatsi otsinguid Saint-Genevieve-des-Boiś linnas Prantsusmaal, tõlge raamatust "Mir i filmõ Andreja Tarkovskogo". 1991

  11. Kuidas õpilasmalevat laiendada? / Alli Lunter, Jüri Ginter, Lembit Jakobson ... [jt.

    Index Scriptorium Estoniae

    2012-01-01

    Küsimusele vastavad: Viljandi maagümnaasiumi õpetaja Alli Lunter, TÜ õppejõud Jüri Ginter, Unipiha kooli õpetaja Lembit Jakobson, riigikogu liige ja demokraatide ühenduse esimees Rainer Vakra ja TLÜ ajalooinstituudi teadur Ain Lavi

  12. Eesti kirjandus suure ilma äärel / Jüri Talvet

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    1999-01-01

    Eesti kirjanduse esindatusest teatmeteoses "Encyclopedia of world literature in the 20th century" (St. James Press, 1999) ja "Der Literatur Brockhaus" (München... [jt.] : B. I. Taschenbuchverlag, 1995). Ilmunud ka kogumikus: Talvet, Jüri. Ameerika märkmed, ehk, Kaemusi Eestist. Tartu : Ilmamaa, 2000, lk. 121-124

  13. Higher Loop Corrections to the Infrared Evolution of Fermionic Gauge Theories in the RI' Scheme

    DEFF Research Database (Denmark)

    Ryttov, Thomas

    2014-01-01

    We study the evolution of the gauge coupling and the anomalous dimension of the mass towards an infrared fixed point for non-supersymmetric gauge theories in the modified regularization invariant, RI', scheme. This is done at the three loop level where all the renormalization group functions have...

  14. Kas Orase Shelley või Shelley Oras? / Jüri Talvet

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    1999-01-01

    Arvustus: Shelley, Percy Bysshe. Valik lüürikat / tlk. Ants Oras; toim. Anne Lange. Tln. : Hortus Litterarum, 1998. Ants Orase ja Minni Nurme tõlgete võrdlus (P. B. Shelley. Luuletusi. Tln., 1960). Ilmunud ka kogumikus: Talvet, Jüri. Tõrjumatu äär. Tartu : Ilmamaa, 2005, lk. 408-416

  15. Jukose kriis toob äikesepilved vaguniäri kohale / Toivo Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Toivo

    2004-01-01

    Russian Estonian Rail Services AS - kõige konkurentsivõimelisem transpordi-, side- ja logistikaettevõtete hulgas, Hansapanga kõrgepalgalise eksportööri eriauhinna laureaat. Lisa: Russian Estonian Rail Services 2003. Kommenteerib Indrek Neivelt. Tabel: Transpordi-, side- ja logistikaettevõtted

  16. GarcÍa Lorca luulest ja Ain Kaalepi tõlkest / Jüri Talvet

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    1998-01-01

    Arvustus: GarcÍa Lorca, Federico. Mu kätes põleb tuli : valitud luuletused / tlk. ja saateks: Ain Kaalep. 2. tr. Tallinn : Vagabund, 1997. Ilmunud ka kogumikus: Talvet, Jüri. Tõrjumatu äär. Tartu : Ilmamaa, 2005, lk. 442-453

  17. Tere, kapten! Saame tuttavaks! / Jüri Bachman ; interv. Aare Tamm

    Index Scriptorium Estoniae

    Bachman, Jüri

    2009-01-01

    Kaitseliidu Lääne maleva väljaõppeülem kapten Jüri Bachman vastab küsimustele, mis puudutavad tema haridusteed, kutseliseks sõjaväelaseks ja hiljem ohvitseriks saamist, senist teenistuskäiku

  18. Assessing the Kha Ri Gude Mass Literacy Campaign: A Developmental Evaluation

    Science.gov (United States)

    Romm, Norma R. A.; Dichaba, Mpho M.

    2015-01-01

    In this article we explicate our way of assessing the South African Kha Ri Gude Mass Literacy Campaign, and in particular its impact in the Eastern Cape. We provide an account primarily of focus group sessions conducted in 2013 and again in 2014 with volunteer educators and past learners in the campaign. We concentrate on the way in which…

  19. 77 FR 20330 - Disestablishment of Restricted Area; Rhode Island Sound off Newport, RI

    Science.gov (United States)

    2012-04-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Department of the Army, Corps of Engineers 33 CFR Part 334 Disestablishment of Restricted Area; Rhode Island Sound off Newport, RI AGENCY: U.S. Army Corps of Engineers, DoD. ACTION: Proposed rule. SUMMARY: The U.S...

  20. Anti-Ri-associated paraneoplastic cerebellar degeneration. Report of a case and revision of the literature.

    Science.gov (United States)

    Mancuso, Michelangelo; Orsucci, Daniele; Bacci, Andrea; Caldarazzo Ienco, Elena; Siciliano, Gabriele

    2011-09-01

    Paraneoplastic cerebellar degeneration associated with anti-Ri antibodies mainly presents with opsoclonus-myoclonus-ataxia. We report here the case of a patient with anti-Ri-antibody paraneoplastic syndrome, who presented four years after treatment for small-cell lung cancer (SCLC) with oscillopsia and gait disorder. On neurological examination vertical nystagmus, ataxic gait and postural tremor of all four limbs was detected. He died one year after the onset of the symptoms because of a acute exacerbation of his severe chronic obstructive pulmonary disease. No SCLC relapse or new cancer has been detected during the one-year follow-up period.To our knowledge, our patient is the first case of anti-Ri associated disorder with oscillopsia and vertical nystagmus as the initially prominent clinical features. The findings of this case study support the variability of anti-Ri-antibody-associated paraneoplastic syndrome. Further studies must be directed to better characterize the mechanisms underlying this syndrome. Finally, paraneoplastic neurological syndromes should be kept in mind also when a neoplastic disease is not demonstrated.

  1. Filamin A stabilizes Fc gamma RI surface expression and prevents its lysosomal routing

    NARCIS (Netherlands)

    Beekman, Jeffrey M.; van der Poel, Cees E.; van der Linden, Joke A.; van den Berg, Debbie L. C.; van den Berghe, Peter V. E.; van de Winkel, Jan G. J.; Leusen, Jeanette H. W.

    2008-01-01

    Filamin A, or actin-binding protein 280, is a ubiquitously expressed cytosolic protein that interacts with intracellular domains of multiple receptors to control their subcellular distribution, and signaling capacity. In this study, we document interaction between Fc gamma RI, a high-affinity IgG

  2. 75 FR 47881 - Noise Exposure Map Notice, T.F.Green Airport, Warwick, RI

    Science.gov (United States)

    2010-08-09

    ... Federal Aviation Administration Noise Exposure Map Notice, T.F.Green Airport, Warwick, RI AGENCY: Federal... its determination that the noise exposure maps for T.F.Green Airport as submitted by the Rhode Island... Date: The effective date of the FAA's determination on the noise exposure maps is July 27, 2010. FOR...

  3. Kuidas käib kultuuri suurandmete äri maailmas? / Indrek Ibrus

    Index Scriptorium Estoniae

    Ibrus, Indrek

    2016-01-01

    Septembri lõpus Eestis toimuvast konverentsist "Culture 4D: Digitisation, Data, Disruptions, Diversity", mille korraldavad Euroopa Nõukogu, kultuuriministeerium ja Tallinna Ülikool. Konverentsi tähelepanu keskmes on kultuurivaldkonna suurandmete majandamine, suurandmete äri, andmete kasutamine üldiseks hüvanguks ning kultuuri digiteerimisega kaasnevad väljakutsed

  4. ri Pihl vstretilsja s Alfredom Perezom Rubalkaba / Kristina Kareva

    Index Scriptorium Estoniae

    Kareva, Kristina

    2008-01-01

    Siseminister Jüri Pihl kohtus Madridis Hispaania siseministri Alfredo Pérez Rubalcabaþga, et arutada politseiasutuste vahelist koostööd, küberkuritegevuse vastast võitlust ja Hispaania eesistumist Euroopa Liidus 2010. aastal

  5. Tagakiusamine ja kirjutamiskunst / Leo Strauss ; järelsõna Jüri Lipping

    Index Scriptorium Estoniae

    Strauss, Leo, 1899-1973

    2000-01-01

    Ajalooliste tekstide ridade vahele peidetud sõnumi lugemisest. Tsensuuri mõjust filosoofilistele tekstidele. Peidetud sõnumi lugemisest lähtuvast erinevusest eelmoodsate ja uusaegsete filosoofide teostes. Jüri Lipping'u järelsõna Leo Straussi filosoofilistest vaadetest.

  6. Tüüri "Magma" kuuplaat. Pärt Saksa romaani kangelasena

    Index Scriptorium Estoniae

    2007-01-01

    Erkki-Sven Tüüri heliplaat "Magma" oli kuuplaat nii BBC Music Magazine'is kui ka Gramophone'is. Saksa kirjanik Adam Thorpe avaldas romaani "Taktverschiebung" ("Taktimuutus"), mille peategelast, inglise heliloojat Jack Middletoni iseloomustatakse Arvo Pärdi suure austajana

  7. Nõukogu kinnitas Türi kolledži õppetöö kolimise Tartusse

    Index Scriptorium Estoniae

    2010-01-01

    Novembrikuu istungil otsustas TÜ nõukogu Türi kolledžis oleva keskkonnakorralduse ja planeerimise õppekava liita Tartus loodus- ja tehnoloogiateaduskonna (LOTE) juurde. TÜ peahoone ees protestisid selle kava vastu kolledži üliõpilased

  8. IRL-i juhtkonna eest hoiti Hansoni pedofiiliaafääri kaua saladuses / Holger Roonemaa

    Index Scriptorium Estoniae

    Roonemaa, Holger

    2009-01-01

    Mitu IRL-i erakonna liiget teadis Kaur Hansoni vahistamisest juba kevadel, kuid erakonnast visati Hanson välja alles tema pedofiiliaafääri avalikustamise järel. Ott Lumi hinnangul olid Hansoni juhtumiga kursis tõenäoliselt pigem Res Publica taustaga inimesed

  9. ri Talvet võeti ida-lääne akadeemia liikmeks

    Index Scriptorium Estoniae

    2011-01-01

    Rumeenias ilmus Jüri Talveti luulekogu "De din somn, de din zapada" ("Unest lumest"), mida autor Curtea de Argese luulefestivalil esitlemas käis. Lisaks pühitseti ta rahvusvahelise ida-lääne akadeemia tegevliikmeks

  10. Meie ühine mure on tervishoid / Jüri Ratas

    Index Scriptorium Estoniae

    Ratas, Jüri, 1978-

    2008-01-01

    Ilmunud ka: Den za Dnjom 1. veebr. lk. 18. Põhjarannik 18. jaan. 2008, lk. 2, Severnoje Poberezhje 18. jaan. 2008, lk. 2, Den za Dnjom 18. jaan. 2008, lk. 2. Riigikogu aseesimees Jüri Ratas tunneb muret Eesti elanike tervise pärast

  11. Kapo uurib Toomas Vitsuti laevaafääri / Mikk Salu, Gert D. Hankewitz

    Index Scriptorium Estoniae

    Salu, Mikk, 1975-

    2011-01-01

    Kaitsepolitseiamet ja Põhja ringkonnaprokuratuur uurivad Tallinna linnavolikogu juhi Toomas Vitsuti ja linnaplaneerimise ameti juhi Toomas Õispuu ühist relva- ja laevaäri Vahemerel. Arco Vara juhtide seotusest linnaaametnikega. Kes on kes Vahemere lõhkeianeäris?

  12. 21 ideed, millest võiks saada monument või skulptuur / Jüri Saar

    Index Scriptorium Estoniae

    Saar, Jüri, 1973-

    2008-01-01

    Tartu linnavalitsus kogus kokku 21 skulptuuride, monumentide ja mälestustahvlite ideed, et esile tõsta auväärseid kaaslinlasi ning ehitisi. Valmis dokument "Tartu linna monumentide ja skulptuuride rajamise kava aastateks 2008-2013". Kommenteerivad Tiit Kaunissaare ja Jüri Sasi

  13. Viru kaevanduse endine juht Jüri Reiska : "Pidime valimiskampaaniaks 100 00 krooni hankima!" / Erik Gamzejev

    Index Scriptorium Estoniae

    Gamzejev, Erik, 1967-

    2007-01-01

    Ilmunud ka: Severnoje Poberezhje, 7. veebr. 2007, lk. 1,4. Jüri Reiska kinnitab, et lasi osa endise Tammiku kaevanduse hooneid 2003. a. fiktiivselt teist korda lammutada, et täita Lembit Kaljuvee antud ülesannet tuua Mati Jostovi Riigikogu valimiskampaania kuludeks ligemale 100 000 krooni. Lembit Kaljuvee eitab väidet

  14. Venemaa vehib Kyoto trumpässaga / Jüri Piirisild

    Index Scriptorium Estoniae

    Piirisild, Jüri

    2004-01-01

    1997. aastal vastuvõetud Kyoto protokoll, mis peaks panema piiri Maa atmosfääri saastamisele ja sellega otseselt seotud kliima soojenemisele, pole siiani vajalikku arvu ratifitseerimisallkirju saanud. Kui Venemaa lepingule alla kirjutab, saab vajalik arv allkirju kokku ning Kyoto lepingu täitmine muutub kohustuslikuks

  15. Vallavanemate hinnang aastatele 2008 ja 2009 / Jüri Lillsoo, Kalmer Märtson, Andre Sepp

    Index Scriptorium Estoniae

    Lillsoo, Jüri, 1943-

    2009-01-01

    Milline oli aasta 2008 Teie valla jaoks, kui silmas pidada kiiret süvenevat majanduslangust? Mida oodata aastast 2009?Küsimustele vastavad Anija vallavanem Jüri Lillsoo, Kuusalu vallavanem Kalmer Märtson ja Raasiku vallavanem Andre Sepp

  16. Tulevane linnapea kavandab kainestusmaja ja Kalevipoega / Jüri Ratas ; interv. Urmas Seaver

    Index Scriptorium Estoniae

    Ratas, Jüri, 1978-

    2005-01-01

    Ilmunud ka: Postimees : na russkom jazõke 14. nov., lk 6. Tõenäoline Tallinna linnapea kandidaat vastab küsimustele, mis puudutavad uue linnavalitsuse esimest istungit, pealinna 2006. aasta eelarvet ning Keskerakonna valimislubadusi linna valitsemisel. Lisa: Jüri Ratas

  17. 76 FR 15246 - Anchorage Regulations; Narragansett Bay and Rhode Island Sound, RI

    Science.gov (United States)

    2011-03-21

    ... Sound, RI AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast Guard... an offshore anchorage in Rhode Island Sound south of Brenton Point, Rhode Island, for use by vessels... Sound that under current informal practice is routinely used by mariners as an anchorage while waiting...

  18. The FcεRI Signaling Cascade and Integrin Trafficking Converge at Patterned Ligand Surfaces.

    Science.gov (United States)

    Wakefield, Devin L; Holowka, David; Baird, Barbara

    2017-08-09

    We examined the spatial targeting of early and downstream signaling mediated by the IgE receptor (FcεRI) in RBL mast cells utilizing surface-patterned 2,4 dinitrophenyl (DNP) ligands. Micron-sized features of DNP are presented as densely immobilized conjugates of bovine serum albumin (DNP-BSA) or mobile in a supported lipid bilayer (DNP-SLB). Although soluble anti-DNP IgE binds uniformly across features for both pattern types, IgE bound to FcεRI on cells shows distinctive distributions: uniform for DNP-SLB and edge-concentrated for DNP-BSA. These distributions of IgE-FcεRI propagate to the spatial recruitment of early signaling proteins, including spleen tyrosine kinase (Syk), linker for activation of T cells (LAT), and activated phospholipase C gamma 1 (PLCγ1), which all localize with engaged receptors. We found stimulated polymerization of F-actin is not required for Syk recruitment but is progressively involved in the recruitment of LAT and PLCγ1. We further found β1- and β3-integrins colocalize with IgE-FcεRI at patterned ligand surfaces as cells spread. This recruitment corresponds to directed exocytosis of recycling endosomes (REs) containing these integrins and their fibronectin ligand. Together, our results show targeting of signaling components, including integrins, to regions of clustered IgE-FcεRI in processes that depend on stimulated actin polymerization and outward trafficking of REs. © 2017 by The American Society for Cell Biology.

  19. The first transmembrane region of the beta-chain stabilizes the tetrameric Fc epsilon RI complex.

    Science.gov (United States)

    Singleton, Theresa E; Platzer, Barbara; Dehlink, Eleonora; Fiebiger, Edda

    2009-07-01

    The family of activating immune receptors stabilizes via the 3-helix assembly principle. A charged basic transmembrane residue interacts with two charged acidic transmembrane residues and forms a 3-helix interface to stabilize receptor complexes in the lipid bilayer. One family member, the high affinity receptor for IgE, Fc epsilon RI, is a key regulator of immediate allergic responses. Tetrameric Fc epsilon RI consists of the IgE-binding alpha-chain, the multimembrane-spanning beta-chain and a dimer of the gamma-subunit (Fc epsilon R gamma). Comparative analysis of these seven transmembrane regions indicates that Fc epsilon RI does not meet the charge requirements for the 3-helix assembly mechanism. We performed alanine mutagenesis to show that the only basic amino acid in the transmembrane regions, beta K97, is not involved in Fc epsilon RI stabilization or surface upregulation, a hallmark function of the beta-chain. Even a beta K97E mutant is functional despite four negatively charged acidic amino acids in the transmembrane regions. Using truncation mutants, we demonstrate that the first uncharged transmembrane domain of the beta-chain contains the interface for receptor stabilization. In vitro translation experiments depict the first transmembrane region as the internal signal peptide of the beta-chain. We also show that this beta-chain domain can function as a cleavable signal peptide when used as a leader peptide for a Type I protein. Our results provide evidence that tetrameric Fc epsilon RI does not assemble according to the 3-helix assembly principle. We conclude that receptors formed with multispanning proteins use different mechanisms of shielding transmembrane charged amino acids.

  20. Fc(epsilon)RI and FcgammaRIII/CD16 differentially regulate atopic dermatitis in mice.

    Science.gov (United States)

    Abboud, Georges; Staumont-Sallé, Delphine; Kanda, Akira; Roumier, Thomas; Deruytter, Nathalie; Lavogiez, Céline; Fleury, Sébastien; Rémy, Patrick; Papin, Jean-Paul; Capron, Monique; Dombrowicz, David

    2009-05-15

    The high-affinity IgE receptor Fc(epsilon)RI and, in some models, the low-affinity IgG receptor Fc(epsilon)RIIII/CD16 play an essential role in allergic diseases. In human skin, they are present on APCs and effector cells recruited into the inflamed dermis. FcRgamma is a subunit shared, among other FcRs, by Fc(epsilon)RI and CD16 and is essential to their assembly and signal transduction. Using an experimental model reproducing some features of human atopic dermatitis and specific FcR-deficient mice, we have herein delineated the respective contribution of Fc(epsilon)RIand Fc(epsilon)RIII/CD16 to the pathology. We demonstrate that symptoms of atopic dermatitis are completely absent in FcRgamma-deficient animals but only partially inhibited in either Fc(epsilon)RI- or FcgammaRIII/CD16-deficient animals. Absence or attenuation of the pathology is correlated to increased skin expression of regulatory IL-10 and Foxp3. While Fc(epsilon)RI controls both Th1 and Th2 skin response, mast cell recruitment into draining lymph nodes and IgE production, CD16 regulates only Th2 skin response, as well as T cell proliferation and IgG1 production. This isotype-specific regulation by the cognate FcR is associated to a differential regulation of IL-4 and IL-21 expression in the draining lymph nodes. Fc(epsilon)RIand CD16 thus contribute to atopic dermatitis but differentially regulate immune responses associated with the disease. Targeting both IgE/Fc(epsilon)RI and IgG/CD16 interactions might represent an efficient therapeutic strategy for allergic diseases.

  1. The Ri chicken breed and livelihoods in North Vietnam: characterization and prospects

    Directory of Open Access Journals (Sweden)

    Pascal Leroy

    2011-06-01

    Full Text Available For the last twenty years, the consumption of poultry meat has boomed in Vietnam as in the rest of the developing world. Capital-intensive production has grown rapidly to satisfy this demand. Based on a few numbers of genetically uniform strains, these systems threaten biodiversity. In Vietnam, both rural and urban households still keep indigenous chickens as part of a diversified livelihood portfolio. In line with the national in situ conservation strategy, this study approached the context of local poultry keeping in two rural and one suburban districts of Northern Vietnam. It aimed at understanding households’ willingness, constraints and opportunities for practice improvement, including breeds’ management. As the Ri chicken constitutes the large majority of backyard flocks, two particular objectives of this study are the morpho-biometric characterisation of phenotypic diversity among individuals classified as Ri by farmers and an assessment of their productive potential. Chicken was found to hold a different place in livelihoods of the three districts with consequences on the management of genetic resources. The most favourable conditions for improvement of the Ri breed was found in the rural district of Luong-Son, due to market integration. In the more remote district of Ky-Son, living standards were lower and much would be gained from Ri conservation. Ri breed was the most threatened in the suburban Gia-Lam district, where poultry was a minor side-activity, lacking incentive for genetic management. From motives and constraints, tracks about breeding goals are suggested. Further considerations about conservation, improvement, market integration and livelihoods are proposed.

  2. Sugar exchanges in arbuscular mycorrhiza: RiMST5 and RiMST6, two novel Rhizophagus irregularis monosaccharide transporters, are involved in both sugar uptake from the soil and from the plant partner.

    Science.gov (United States)

    Ait Lahmidi, Nassima; Courty, Pierre-Emmanuel; Brulé, Daphnée; Chatagnier, Odile; Arnould, Christine; Doidy, Joan; Berta, Graziella; Lingua, Guido; Wipf, Daniel; Bonneau, Laurent

    2016-10-01

    Arbuscular mycorrhizal (AM) fungi are associated with about 80% of land plants. AM fungi provide inorganic nutrients to plants and in return up to 20% of the plant-fixed CO2 is transferred to the fungal symbionts. Since AM fungi are obligate biotrophs, unraveling how sugars are provided to the fungus partner is a key for understanding the functioning of the symbiosis. In this study, we identified two new monosaccharide transporters from Rhizophagus irregularis (RiMST5 and RiMST6) that we characterized as functional high affinity monosaccharide transporters. RiMST6 was characterized as a glucose specific, high affinity H(+) co-transporter. We provide experimental support for a primary role of both RiMST5 and RiMST6 in sugar uptake directly from the soil. The expression patterns of RiMSTs in response to partial light deprivation and to interaction with different host plants were investigated. Expression of genes coding for RiMSTs was transiently enhanced after 48 h of shading and was unambiguously dependent on the host plant species. These results cast doubt on the 'fair trade' principle under carbon-limiting conditions. Therefore, in light of these findings, the possible mechanisms involved in the modulation between mutualism and parasitism in plant-AM fungus interactions are discussed. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  3. 76 FR 18812 - Submission for Review: We Need the Social Security Number of the Person Named Below, RI 38-45

    Science.gov (United States)

    2011-04-05

    ... MANAGEMENT Submission for Review: We Need the Social Security Number of the Person Named Below, RI 38-45... the Social Security Number of the Person Named Below, RI 38-45. As required by the Paperwork Reduction... Number of the Person Named Below, RI 38-45, is used by the Civil Service Retirement System and the...

  4. Ääremärkused diagnoosiks : Imagosfäär tulgu I = Remarks for diagnosis : Imagosphere Come I / Jüri Soolep

    Index Scriptorium Estoniae

    Soolep, Jüri, 1962-

    2008-01-01

    Imagosfääri empiiriline kehtestumine: meedia, Gutenbergi galaktika, isiklik imagosfäär. Imagosfääri teoreetiline konstitutsioon: simulaakrumid ja hüperreaalsus. Imagosfääri praktiline realisatsioon: Putini Venemaa. Artikkel põhineb Eesti Kunstiakadeemias 2007. a. sügissemestril peetud loengukursusel "Linnaehituse nüüdisaegsed probleemid". Bibliograafia lk. 38

  5. Estudio de reduccio?n de consumo de energi?a de las refrigeradoras RI-390 y RI-480 de “Indurama”

    OpenAIRE

    Minchala Chumbi, Wilson; Castillo, Fausto Orlando

    2012-01-01

    El sistema de refrigeracio?n es parte fundamental en la conservacio?n de alimentos y por eso existe una creciente demanda en la produccio?n de refrigeradoras dome?sticas, de ahi? que sea necesario un compromiso de calidad, ahorro energe?tico y disen?o, estando a la vanguardia de nuevas tecnologi?as y estrategias para el mejoramiento de los materiales, la eficiencia energe?tica, los costos, etc. Para desarrollar el presente tema se han tomado datos te?cnicos de las refrigeradoras RI-390 fro...

  6. Massively parallel algorithm and implementation of RI-MP2 energy calculation for peta-scale many-core supercomputers.

    Science.gov (United States)

    Katouda, Michio; Naruse, Akira; Hirano, Yukihiko; Nakajima, Takahito

    2016-11-15

    A new parallel algorithm and its implementation for the RI-MP2 energy calculation utilizing peta-flop-class many-core supercomputers are presented. Some improvements from the previous algorithm (J. Chem. Theory Comput. 2013, 9, 5373) have been performed: (1) a dual-level hierarchical parallelization scheme that enables the use of more than 10,000 Message Passing Interface (MPI) processes and (2) a new data communication scheme that reduces network communication overhead. A multi-node and multi-GPU implementation of the present algorithm is presented for calculations on a central processing unit (CPU)/graphics processing unit (GPU) hybrid supercomputer. Benchmark results of the new algorithm and its implementation using the K computer (CPU clustering system) and TSUBAME 2.5 (CPU/GPU hybrid system) demonstrate high efficiency. The peak performance of 3.1 PFLOPS is attained using 80,199 nodes of the K computer. The peak performance of the multi-node and multi-GPU implementation is 514 TFLOPS using 1349 nodes and 4047 GPUs of TSUBAME 2.5. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  7. A comparative study of the FcepsilonRI molecule on human mast cell and basophil cell lines

    DEFF Research Database (Denmark)

    Jensen, Bettina Margrethe; Dissing, S; Skov, P S

    2005-01-01

    Mast cells and basophils express the high-affinity IgE receptor FcepsilonRI. We have analysed the human mast cell line LAD2 and four subclones of the basophil cell line KU812 in order to reveal possible differences concerning the FcepsilonRI surface regulation, anti-IgE-triggered activation, Fcep......, FcepsilonRIalpha protein stability and the mRNA level of FcepsilonRIalpha-, beta- and the truncated beta-chain (beta(T)), and thereby determine the utility of these cell lines in investigations of the FcepsilonRI biology....

  8. Preoperative tumor localization of primary hyperparathyroidism. Comprehensive study of ultrasonography (US), scintigraphy (RI), arteriography (AG) and venous sampling (VS)

    Energy Technology Data Exchange (ETDEWEB)

    Morita, Yutaka; Shinohara, Masahiro; Ito, Kazuo; Imamura, Fumimoto; Kasai, Yoichi (Hokkaido Univ., Sapporo (Japan). School of Medicine); Ishizuka, Reiki

    1983-02-01

    The diagnostic rate of each methods were discussed in thirty six cases and the following conclusions were made. (1.) The diagnostic rate of US, RI, AG and VS was 64.7%, 50%, 57.9%, 60.7% respectively. (2.) Ultrasonography and subtruction-scintigraphy were useful for screening examination for localization of parathyroid tumor. (3.) The reasonable diagnostic procedures were as follows: (1) In the cases of palpable, reno-uretrolithiasic type, and biochemical type: US ..-->.. RI ..-->.. VS. (2) In the cases of nonpalpable osteolytic type, and previous neck surgery: US ..-->.. RI ..-->.. AG ..-->.. VS. These results indicate that the systemic diagnoses are useful to predict localization of parathyroid tumors.

  9. Nuclear astrophysics projects at the low-energy RI beam separator CRIB

    Science.gov (United States)

    Yamaguchi, H.; Kahl, D.; Hayakawa, S.; Yang, L.; Shimizu, H.; Sakaguchi, Y.; Abe, K.; Nakao, T.; Suhara, T.; Iwasa, N.; Kim, A.; Kim, D. H.; Cha, S. M.; Kwag, M. S.; Lee, J. H.; Lee, E. J.; Chae, K. Y.; Wakabayashi, Y.; Imai, N.; Kitamura, N.; Lee, P.; Moon, J. Y.; Lee, K. B.; Akers, C.; Jung, H. S.; Duy, N. N.; Khiem, L. H.; Lee, C. S.; Hashimoto, T.; Kubono, S.; Kawabata, T.; Teranishi, T.; Kwon, Y. K.; Binh, D. N.

    2018-01-01

    Studies on nuclear reactions relevant for astrophysics have been performed using the radioactive-isotope (RI) beams at the low-energy RI beam separator CRIB, operated by Center for Nuclear Study (CNS), the University of Tokyo. A type of measurement to study astrophysical reactions at CRIB is by the elastic resonant scattering with the thick-target method in inverse kinematics. We introduce the α resonant scattering with 7Be beam, related to the astrophysical 7Be(α, γ) reactions, which is relevant in the hot p-p chain and νp-process in supernovae. Other α resonant scattering measurements with 30S, 10Be, 15O, and 18Ne beams have been performed at CRIB, using the thick-target method.

  10. RI-MP2: optimized auxiliary basis sets and demonstration of efficiency

    Science.gov (United States)

    Weigend, Florian; Häser, Marco; Patzelt, Holger; Ahlrichs, Reinhart

    1998-09-01

    Applications of the RI-MP2 method require high-quality auxiliary basis sets employed to approximate charge distributions. A variational procedure is proposed and applied to optimize auxiliary bases for main group and transition metal atoms which are tested for more than 350 molecules. The RI approximation affects molecular MP2 energies by less than 60 μ Eh per atom and equilibrium distances by less than 0.2 pm. We further comment on the extension from RHF to UHF and the exploitation of molecular symmetry. Applications to (Cu 2S) n clusters and hydrocarbons C nH 2 n+2 document a significant reduction of computation times which allows for calculations with up to 1000 basis functions in C 1 symmetry.

  11. DETERMINATION OF ATTENUATION INDEX CURVE "Ri(f" FOR HOMOGENEOUS DOUBLE LOCKING ELEMENTS

    Directory of Open Access Journals (Sweden)

    BUZATU G. C.

    2016-12-01

    Full Text Available The paper is structured in three parts. In the first part of the paper, are presented some theoretical notions regarding the sound, noise, the sound insulations materials. Also in the first part of the paper are presented some characteristic regarding the insulation materials and there effects. In the second part it is described an calculation example for a homogeneous wall with double structure in order to determine the attenuation index curve "Ri(f". The example calculation contains 10 steps that must be followed and the final results are presented in table 7 and figure 3. The last part of the paper is represented by conclusions, where the authors tried to explain the importance of the curve "Ri(f" for reducing the noise in the buildings.

  12. Correlated genetic and EcoRI cleavage map of Bacillus subtilis bacteriophage phi105 DNA.

    Science.gov (United States)

    Scher, B M; Law, M F; Garro, A J

    1978-10-01

    The seven previously identified EcoRI cleavage fragments of phi 105 DNA were ordered with respect to their sites of origin on the phage genome by marker rescue. One fragment, H, did not carry any determinants essential for replication. This fragment was totally missing in a deletion mutant which exhibited a lysogenization-defective phenotype. There is a nonessential region on the phi 105 genome which begins in fragment B, spans fragment H, and ends in fragment F. The size of the nonessential region, as estimated by alterations observed in the fragmentation patterns of deletion mutant DNAs, is approximately 2.7 X 10(6) daltons. Two new EcoRI cleavage fragments with molecular weights of approximately 0.2 X 10(6) were detected by autoradiography of 32P-labeled DNA. These small fragments were not located on the cleavage map.

  13. Simulasi Dampak Liberalisasi Perdagangan Bilateral RI-China terhadap Perekonomian Indonesia: Sebuah Pendekatan SMART Model

    Directory of Open Access Journals (Sweden)

    Sulthon Sjahril Sabaruddin

    2013-12-01

    Full Text Available This paper attempts to evaluate the impact of trade liberalization between Indonesia and China to the Indonesian economy. In order to evaluate the impact on the Indonesian economy,the study uses a method of model analysis so-called Software for Market Analysis and Restrictions on Trade (SMART. The implications of the impact RI-China trade liberalization analysis in 2009 with a complete tariff dismantlement are the welfare of the Indonesian society, by utilizing the analysis of change in Consumer Surplus and a decrease in Deadweighted Loss. The paperconcludes that trade liberalization RI-China with zero tariffs results in a positive impact on the welfare of the Indonesian society.

  14. RiSA: A Science Festival for the Bilingual and Bicultural Rio Grande Valley

    Science.gov (United States)

    Key, Joey Shapiro; Torres, Cristina; Stone, Robert

    2014-03-01

    The Rio Grande Science and Arts (RiSA) Festival organized by the Center for Gravitational Wave Astronomy (CGWA) at the University of Texas at Brownsville (UTB) will use a wide variety of artforms to bring physics and science topics to the bilingual and bicultural population of the Rio Grande Valley of South Texas. The science and art faculty at UTB will partner with art and education professionals to create an annual community event celebrating science though art. Music, dance, poetry, and visual arts will headline the festival activities. Festival events and products will be produced in both English and Spanish to attract and inform the bilingual local community. The RiSA Festival is supported by the Science Festival Alliance and the Sloan Foundation. Supported by the Science Festival Alliance and the Sloan Foundation.

  15. Perkembangan Daya Saing Ekspor Ri-China Selama Periode 1985-2010: suatu Pelajaran Bagi Indonesia

    OpenAIRE

    sabaruddin, sulthon sjahril

    2013-01-01

    RI-China Export Competitivess Development during 1985-2010 : A Lesson for IndonesiaThis paper is intended to evaluate the development and changes in the structure of the Indonesian and China exports comparative advantage (the competitiveness of exports) during the period of 1985-2010. The results of the empirical analysis for the exports comparative advantage shows thatduring the period of 1985-2010, the trend of structure development of the competitiveness of Indonesian exports is now more d...

  16. Professor Jüri Talvetist sai Ida-Lääne akadeemia liige / intervjueerinud Rein Veidemann

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    2011-01-01

    Intervjuu Tartu ülikooli maailmakirjanduse professori Jüri Talvetiga luulefestivalist Curtea de Argeş ("Nopţile de Poezie de la Curtea de Argeş") ja tema rumeenia keelde tõlgitud luulekogust „Unest, lumest” ("De din somn, de din zăpadă" - tõlkija Dumitru M. Ion), mida autor seal esitlemas käis ning Ida-Lääne akadeemiast (Academia Internationala Orient-Occident), mille tegevliikmeks ta valiti

  17. ri Kasel on väljas kaks suurt näitust : ...

    Index Scriptorium Estoniae

    2005-01-01

    Kuni 6. I 2006 saab Belgias Liege'i kaasaegse kunsti keskuses vaadata Jüri Kase suuri maale, paarisadat joonistust ning objekti ja kuni 12. XII Inglismaal Oxfordi Jacqueline du Pre muusikahoones maale. Liege'i näitusel on väljas ka Jaanus Miku tehtud video "Pinta pilte". 22.-26. XI Eesti kultuuripäevadel Oxfordis esines Weekend Guitar Trio, Kristiina Ehin luges luulet, näidati Priit Tenderi ja Ülo Pikkovi animafilme

  18. Sarviline must Gulliver heledate kääbikute keskel / Jüri Kuuskemaa

    Index Scriptorium Estoniae

    Kuuskemaa, Jüri, 1942-

    2009-01-01

    Arhitektuuribüroo Kosmos arhitektide Villem Tomiste, Ott Kadariku ja Mihkel Tüüri kavandatud valmimisjärgus äripindadega kortermaja Aia ja Vana-Viru t. nurgal Tallinna vanalinnas ei sulandu traditsioonilisse keskkonda. Eesti Muinsuskaitse Selts andis sümboolselt Karuteene medali isikutele ja institutsioonidele, kelle tõttu sai võimalikuks selle mastaabilt ja kujunduselt sobimatu uusehitise püstitamine vanalinna. Vastuseks Liina Tamme artiklile (Eesti Päevaleht, 2009, 16. juuli, lk. 7)

  19. XX sajandi hispaania teater : peamärgid / Jüri Talvet

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    1998-01-01

    Hispaania ja ladinaameerika näitekirjandusest. Ka näidendite lavastamisest eesti teatrites. Põhjalikumalt Ram̤n MarÍa del Valle-Incl{u00E1ni (1866-1936), Federico GarcÍa Lorca (1898-1936) ja Antonio Buero Vallejo (sünd. 1916) loomingust. Ilmunud ka kogumikus: Talvet, Jüri. Tõrjumatu äär. Tartu : Ilmamaa, 2005, lk. 234-250

  20. Pronkssõduri valvaja äri ebaõnnestus / Koit Brinkmann

    Index Scriptorium Estoniae

    Brinkmann, Koit

    2007-01-01

    Turvafirma Legion Security maksis 2006. aastal oma töötajatele raha palkadeks rohkem kui oli ettevõtte käive, aasta lõpetas turvafirma 2,94 miljoni krooni suuruse kahjumiga. Firma omanik Denis Vassiljev põhjendas kahjumit äriprojekti ebaõnnestumisega. Lisa: Vassiljev ajab hoogsalt kinnisvaraäri; Palgakulu ületab käibe; Taust

  1. Uudised : Eesti muusikalistaarid Euroopas. Tüüri 5.sümfoonia Tallinnas

    Index Scriptorium Estoniae

    2005-01-01

    Koit Toome, Ele Millistver ja Lauri Liiv alustavad 1. detsembril Brnos rahvusvahelises muusikalitrupis "Hairi" proovidega. Esietendus on 26. dets. Iserlohni linnas Saksamaal ning etendusi antakse järgmise aasta 16. aprillini Saksa linnades, Austrias, Šveitsis ja Taanis. Erkki-Sven Tüüri 5. sümfoonia tuleb Eestis esiettekandele 10. dets. Estonia Kontserdisaalis, teose esiettekannet selle aasta veebruaris Stuttgardis dirigeeris Olari Elts

  2. Riigikohus arutleb autode üle / Ranno Tingas, Lemmi Kann ; kommenteerinud Jüri Allikalt

    Index Scriptorium Estoniae

    Tingas, Ranno, 1976-

    2009-01-01

    Riigikohtu lahenditest 3-3-1-93-08, 3-3-1-44-00, Tallinna Ringkonnakohtu lahendist 2-3-143/2002 sõiduautode erisoodustuse küsimuses. Kommenteerib Maksukonsultandi UÜ jurist, Eesti Maksumaksjate Liidu (EML) juhatuse liige Jüri Allikalt. Lisa: Maksuamet: sõidupäevikud ei kao kuhugi / Lemmi Kann (ÄP Online, 05.03.2009) ; MTA pressiteade ; EML teabenõue ; MTA vastus

  3. ri viin : aasta jagu pohmellita võidujoovastust / Cathryne Davis ; interv. Neeme Raud

    Index Scriptorium Estoniae

    Davis, Cathryne

    2003-01-01

    Ameerika Ühendriikides müüdavatest Eesti viinadest on kõige suurema edu saavutanud Türi vodka. New-Yorgi suhtekorraldusfirma Deussen Global Comunications'i esindaja Cathryne Davis näeb müügiedu põhjustena viina kõrget kvaliteeti, turundusalast koostööd rahvusvaheliselt tuntud Bacardi'ga, eliidile suunatud sponsorlust, ulatuslikku müügivõrku ja edukat reklaamikampaaniat

  4. Trasplante de riñones embrionarios: una alternativa a la escasez de donantes

    OpenAIRE

    GARCÍA DOMÍNGUEZ, XIMO

    2014-01-01

    [ES] Actualmente, la prevalencia de las enfermedades renales crónicas “ERC” sigue Superando el desarrollo de estrategias de tratamiento eficaces, por lo que Aquellos pacientes con enfermedades avanzadas deben a recurrir a terapias De remplazo renal, como la hemodiálisis o la diálisis peritoneal. El presente trabajo tiene como objetivo comprobar la capacidad de desarrollo De los metanefros (riñones embrionarios) al ser implantados en un organismo Adulto sin necesidad de inmun...

  5. Vettus üritas äri ka koos tuntud nimedega / Villy Paimets

    Index Scriptorium Estoniae

    Paimets, Villy, 1972-

    2006-01-01

    Einar Vettus üritas maavahetusäri Otepää Looduspargis ajada ka koos Oliver Kruuda, Margus Kanguri ja Toomas Kõuhknaga, kuid tehing ebaõnnestus. Küsimustele vastab Margus Kangur. Vt. samas: Seitsmel omanikul tihedad ärisidemed; Kesklinna krundid tulid kätte; Siim Kallas: hea, et Eestis korruptandid kätte saadakse; Anne Oja. Kinnisvarahai ja advokaadi tandem võlus majanduskeelud elamumaaks

  6. Euroopa firmad on asunud oma äri ümber korraldama / Ralph Atkins, Peggy Hollinger

    Index Scriptorium Estoniae

    Atkins, Ralph

    2004-01-01

    Euroopa Liidu juhtide sõnul liigutakse aeglaselt 2000. aastal Lissaboni tippkohtumisel seatud sihtidele viia Euroopa majandus konkurentsivõimelt esikohale maailmas. Euroopa ettevõtted on asunud äri ümberstruktureerima eesmärgiga kärpida kulusid ja leida firmade konkurentsieeliseid. Lisad: Muundumine nagu õpikus; Ümberkorraldamise tulemused siiani teadmata; Erik Aru. Eestis on eduka restruktureerimise näiteks Baltika ja Harju Elekter

  7. Uudised : Tüüri esiettekanne Frankfurdis. Corelli Musicult "Jõulud mõisas"

    Index Scriptorium Estoniae

    2006-01-01

    22., 23. ja 24. nov. Frankfurdi Alte Operis esiettekandele tulevast Erkki-Sven Tüüri uuest "Klaverikontserdist". Eesti-Tšiili trio Raivo Tafenau - Meelis Vind - Ricardo Padilla kontsertidest sarja "Mõisaromantika" raames 25. nov. Taagepera lossis Valgamaal, 26. nov. Tõstamaa mõisas Pärnumaal ja 16. dets. Vihterpalu mõisas Harjumaal. Hans Neuenfelsi lavastatud Mozarti ooperist "Idemeneo" Deutsche Operis Berliinis. Inglise ansambli Procol Harumi hiti "A Whiter Shade of Pale" autoriõigustest

  8. Pelaksanaan PP RI No.19/2008 Sebagai Acuan Kinerja Camat pada Aspek Pemerintahan dan Pendidikan

    Directory of Open Access Journals (Sweden)

    Merry Chairina DM. Sinaga

    2015-06-01

    Full Text Available This study aims to determine the performance camat in the governance and education, which refers to PP RI No.19 / 2008. Researchers used descriptive method implemented in the District Percut Sei Tuan. The sample was the whole population is with 37 employees and only have a single variable: the implementation of PP RI No.19 / 2008 as a reference to the performance of district head in the governance and education in the District Percut Sei Tuan, Deli Serdang regency. Data collection techniques by observation through the observation either directly or indirectly to the subject under study. In this study the authors conducted interviews with respondents who considered berkopetensi in this study. The results showed that the performance camat in the governance and education, which refers to PP RI No.19 / 2008 can be categorized as good, such as the active role undertaken whenever a meeting / conference with employees and citizens. Often talked about the problem of improving the quality of work and education, an invitation to attend the big day, receiving the proposal / opinion of the district head in the field of government development issues of education, accepted the proposal of the villagers regarding the development of education, and play an active role in. arrangements regarding the education in collaboration with third parties.

  9. Dating the Bibong-ri Neolithic site in Korea: Excavating the oldest ancient boat

    Energy Technology Data Exchange (ETDEWEB)

    Park, Gyujun, E-mail: danielp@kigam.re.k [Geochemical Analysis Center, Geologic Environment Division, Korea Institute of Geoscience and Mineral Resources 305-350 (Korea, Republic of); Kim, Jong-Chan [Department of Physics and Astronomy, Seoul National University, Seoul 151-742 (Korea, Republic of); Youn, Minyoung; Yun, Chongcheol; Kang, Jin; Song, Yong-Mi; Song, Su-Jin; Noh, Hye-Jin [Electrostatic Accelerator Research Center, NCIRF, Seoul National University, Seoul 151-742 (Korea, Republic of); Kim, Do-Kyun [Department of Physics and Astronomy, Seoul National University, Seoul 151-742 (Korea, Republic of); Im, Hack-Jong [Gimhae National Museum, Gimhae, Gyeongsangnam-do 621-060 (Korea, Republic of)

    2010-04-15

    The remains of an ancient wooden boat were unearthed at the Bibong-ri shell mound site. The site was located at Bibong-ri, Bugog-myeon, Changnyeong-gun, Gyeongsangnam-do in South Korea. A substantial fragment of the vessel was discovered in the lowest layer of the site. We collected 17 samples of charcoal and wood from pebble, sand, and shell layers. Sample preparation extracted the carbon from each sample material and converted it into graphite for AMS radiocarbon dating. Radiocarbon dates of the samples indicate that they belong to the Neolithic period and that the boat dates from ca. 5700 BC. To this point, the oldest known boat in the world has been a wooden boat dating from ca. 5500 BC in China. Other ancient boats from around the world include a logboat dating from ca. 3600 BC in Japan and a fleet of wooden boats dating from ca. 3000 BC in Egypt. The Bibong-ri boat is the first boat from the Neolithic period ever found in South Korea and must represent one of the world's oldest known boats.

  10. [Paraneoplastic limbic encephalitis with positive anti-RI antibodies and mediastinal seminoma].

    Science.gov (United States)

    Launay, M; Bozzolo, E; Venissac, N; Delmont, E; Fredenrich, A; Thomas, P

    2008-01-01

    We report the case of a 49-year-old man who was admitted for progressive behaviorial disorders with frontal elements. There was no sensorial nor motor deficiency. Clinical examination revealed android obesity, cutaneous and mucous paleness, pubic and axillary depilation and gynecomastia. Encephalic MRI found a lesion of the left amygdalian region with high T2 intensity and low T1 intensity associated with gadolinium-enhancement. Cerebrospinal fluid analysis showed a lymphocytic meningitis. Panhypopituitarism was found on the endocrine investigations. Anti-RI antibodies were positive, leading to the diagnosis of paraneoplastic limbic encephalitis. The CT-scan showed a node of the lower part of the thymic area. Surgical resection revealed an ectopic mediastinal seminoma. The evolution consisted of paraneoplastic fever and crossed-syndrome with right hemiparesia and left common oculomotor nerve paralysis. Treatment was completed by two cycles of carboplatin, corticosteroids and substitutive opotherapy. Paraneoplastic fever disappeared, but behavioral disorders and palsy remain unchanged. The patient died two years later in a bedridden state. This case of paraneoplastic limbic encephalitis associated with positive anti-RI antibodies and mediastinal seminoma is exceptional and has not to our knowledge been described in the literature. Cancers usually associated with anti-RI antibody are breast and lung cancer. Paraneoplastic limbic encephalitis is not the classical clinical presentation, which usually is brainstem encephalitis. Hypothalamic involvement, uncommon in paraneoplastic limbic encephalitis is mainly associated with positive antineuronal anti-Ma2 antibodies. Finally, the gadolinium enhancement on encephalic MRI is unusual in paraneoplastic limbic encephalitis.

  11. The importance of human FcgammaRI in mediating protection to malaria.

    Directory of Open Access Journals (Sweden)

    Richard S McIntosh

    2007-05-01

    Full Text Available The success of passive immunization suggests that antibody-based therapies will be effective at controlling malaria. We describe the development of fully human antibodies specific for Plasmodium falciparum by antibody repertoire cloning from phage display libraries generated from immune Gambian adults. Although these novel reagents bind with strong affinity to malaria parasites, it remains unclear if in vitro assays are predictive of functional immunity in humans, due to the lack of suitable animal models permissive for P. falciparum. A potentially useful solution described herein allows the antimalarial efficacy of human antibodies to be determined using rodent malaria parasites transgenic for P. falciparum antigens in mice also transgenic for human Fc-receptors. These human IgG1s cured animals of an otherwise lethal malaria infection, and protection was crucially dependent on human FcgammaRI. This important finding documents the capacity of FcgammaRI to mediate potent antimalaria immunity and supports the development of FcgammaRI-directed therapy for human malaria.

  12. Studying astrophysical reactions with low-energy RI beams at CRIB

    Directory of Open Access Journals (Sweden)

    Yamaguchi H.

    2016-01-01

    Full Text Available Studies on nuclear astrophysics, nuclear structure, and other interests have been performed using the radioactive-isotope (RI beams at the low-energy RI beam separator CRIB, operated by Center for Nuclear Study (CNS, the University of Tokyo. A typical measurement performed at CRIB is the elastic resonant scattering with the inverse kinematics. One recent experiment was on the α resonant scattering with 7Li and 7Be beams. This study is related to the astrophysical 7Li/7Be(α,γ reactions, important at hot p-p chain and νp-process in supernovae. There have also been measurements based on other experimental methods. The first THM measurement using an RI beam has been performed at CRIB, to study the 18F(p, α15O reaction at astrophysical energies via the three body reaction 2H(18F, α15On. The 18F(p, α 15O reaction rate is crucial to understand the 511-keV γ-ray production in nova explosion phenomena, and we successfully evaluated the reaction cross section at novae temperature and below experimentally for the first time.

  13. TGF-βRI kinase activity mediates Emdogain-stimulated in vitro osteoclastogenesis.

    Science.gov (United States)

    Gruber, Reinhard; Roos, Gilles; Caballé-Serrano, Jordi; Miron, Rick; Bosshardt, Dieter D; Sculean, Anton

    2014-07-01

    Emdogain, containing an extract of fetal porcine enamel matrix proteins, is a potent stimulator of in vitro osteoclastogenesis. The underlying molecular mechanisms are, however, unclear. Here, we have addressed the role of transforming growth factor-beta receptor type 1 (TGF-βRI) kinase activity on osteoclastogenesis in murine bone marrow cultures. Inhibition of TGF-βRI kinase activity with SB431542 abolished the effect of Emdogain on osteoclastogenesis induced by receptor activator of nuclear factor kappa-B ligand or tumor necrosis factor-alpha. SB431542 also suppressed the Emdogain-mediated increase of OSCAR, a co-stimulatory protein, and dendritic cell-specific transmembrane protein and Atp6v0d2, the latter two being involved in cell fusion. Similar to transforming growth factor-beta1 (TGF-β), Emdogain could not compensate for the inhibition of IL-4 and IFNγ on osteoclast formation. When using the murine macrophage cell line RAW246.7, SB431542 and the smad-3 inhibitor SIS3 blocked Emdogain-stimulated expression of the transcription factor NFATc1. Taken together, the data suggest that TGF-βRI kinase activity is necessary to mediate in vitro effects of Emdogain on osteoclastogenesis. Based on these in vitro data, we can speculate that at least part of the clinical effects of Emdogain on osteoclastogenesis is mediated via TGF-β signaling.

  14. Experimental Studies of Light-Ion Nuclear Reactions Using Low-Energy RI Beams

    Science.gov (United States)

    Yamaguchi, H.; Kahl, D.; Hayakawa, S.; Sakaguchi, Y.; Abe, K.; Shimuzu, H.; Wakabayashi, Y.; Hashimoto, T.; Cherubini, S.; Gulino, M.; Spitaleri, C.; Rapisarda, G. G.; La Cognata, M.; Lamia, L.; Romano, S.; Kubono, S.; Iwasa, N.; Teranishi, T.; Kawabata, T.; Kwon, Y. K.; Binh, D. N.; Khiem, L. H.; Duy, N. N.; Kato, S.; Komatsubara, T.; Coc, A.; de Sereville, N.; Hammache, F.; Kiss, G.; Bishop, S.

    CRIB (CNS Radio-Isotope Beam separator) is a low-energy RI beam separator of Center for Nuclear Study (CNS), the University of Tokyo. Studies on nuclear astrophysics, nuclear structure, and other interests have been performed using the RI beams at CRIB, forming international collaborations. A striking method to study astrophyiscal reactions involving radioactive nuclei is the thick-target method in inverse kinematics. Several astrophysical alpha-induced reactions have been be studied with that method at CRIB. A recent example is on the α resonant scattering with a radioactive 7Be beam. This study is related to the astrophysical 7Be(α , γ ) reactions, important at hot p-p chain and ν p-process in supernovae. There have been measurements based on several indirect methods, such as the asymptotic normalization coefficient (ANC) and Trojan horse method (THM). The first THM measurement using an RI beam has been performed at CRIB, to study the 18F(p, α )15O reaction at astrophysical energies via the three body reaction 2H(18F, α 15O)n. The 18F(p, α )15O reaction rate is crucial to understand the 511-keV γ -ray production in nova explosion phenomena, and we successfully evaluated the reaction cross section at novae temperature and below experimentally for the first time.

  15. Studying astrophysical reactions with low-energy RI beams at CRIB

    Science.gov (United States)

    Yamaguchi, H.; Kahl, D.; Hayakawa, S.; Sakaguchi, Y.; Wakabayashi, Y.; Hashimoto, T.; Cherubini, S.; Gulino, M.; Spitaleri, C.; Rapisarda, G. G.; La Cognata, M.; Lamia, L.; Romano, S.; Kubono, S.; Iwasa, N.; Teranishi, T.; Kawabata, T.; Kwon, Y. K.; Binh, D. N.; Khiem, L. H.; Duy, N. N.; Kato, S.; Komatsubara, T.; Coc, A.; De Sereville, N.; Hammache, F.; Kiss, G.; Bishop, S.

    2016-05-01

    Studies on nuclear astrophysics, nuclear structure, and other interests have been performed using the radioactive-isotope (RI) beams at the low-energy RI beam separator CRIB, operated by Center for Nuclear Study (CNS), the University of Tokyo. A typical measurement performed at CRIB is the elastic resonant scattering with the inverse kinematics. One recent experiment was on the α resonant scattering with 7Li and 7Be beams. This study is related to the astrophysical 7Li/7Be(α,γ) reactions, important at hot p-p chain and νp-process in supernovae. There have also been measurements based on other experimental methods. The first THM measurement using an RI beam has been performed at CRIB, to study the 18F(p, α)15O reaction at astrophysical energies via the three body reaction 2H(18F, α15O)n. The 18F(p, α) 15O reaction rate is crucial to understand the 511-keV γ-ray production in nova explosion phenomena, and we successfully evaluated the reaction cross section at novae temperature and below experimentally for the first time.

  16. Isamaaline tundmus : Eesti ja Soome kirjamees Jüri Tilk ehk Yrjö Virula / Anu Pallas

    Index Scriptorium Estoniae

    Pallas, Anu, 1960-

    2010-01-01

    Avaliku elu tegelasest, ajakirjanikust ja karskuskirjanduse rajajast Jüri Tilgast, kes 19. sajandi lõpul töötas aktiivselt üldtuntud rahvajuhtide kõrval, olles ka Ado Grenzsteini lähim aatekaaslane

  17. Metoodika väljatöötamine konfliktide uurimiseks äriühingute valitsemisel / Kristo Viksi

    Index Scriptorium Estoniae

    Viksi, Kristo

    2005-01-01

    2004. a. Eesti erialases ajakirjanduses ilmunud artiklite analüüsist, millest selgus, millised konfliktid esinevad Eesti äriühingute valitsemises, millised on nende tunnused ja kuidas neid on lahendatud

  18. Uudised : Lassmann Konservatooriumide Assotsiatsiooni juhatuses. Algab "Con brio 2000". Erkki-Sven Tüüri autorikontsert / Annika Koppel

    Index Scriptorium Estoniae

    Koppel, Annika

    2000-01-01

    P. Lassmann valiti Euroopa Konservatooriumide Assotsiatsiooni juhatuse liikmeks. Eesti noorte interpreetide konkurssfestivalist "Con brio 2000". Tallinna metodisti kirikus toimub 24. nov. E.-S. Tüüri autorikontsert

  19. Interferons modulate Fc epsilon RI-dependent production of autoregulatory IL-10 by circulating human monocytoid dendritic cells.

    Science.gov (United States)

    Le, Trong; Tversky, Jody; Chichester, Kristin L; Bieneman, Anja P; Huang, Shau-Ku; Wood, Robert A; Schroeder, John T

    2009-01-01

    Immature human blood monocytoid dendritic cells (mDCs) express high-affinity receptors for IgE (Fc epsilon RI), yet their exact function and regulation remain poorly understood. We sought to characterize Fc epsilon RI-dependent cytokine responses and their regulation in circulating human blood mDCs. Fc epsilon RI-dependent cytokine responses of circulating mDCs were studied by using anti-Fc epsilon RI alpha stimulation. Plasmacytoid dendritic cell (pDC) cross-regulation through Toll-like receptor 9 on these responses was investigated by examining the effects of exogenous IFN-alpha pretreatment and by coculturing pDCs and mDCs stimulated with CpG. Culture supernatants were analyzed by means of ELISA to determine cytokine levels. Cell markers were determined by means of flow cytometry. mDCs express marked levels of Fc epsilon RI (net mean fluorescence intensity, 196 +/- 49; n = 4). After Fc epsilon RI-dependent activation in mDCs, TNF-alpha (2189 +/- 864 pg/10(6) mDCs, n = 3) levels were upregulated within 4 hours, whereas IL-10 (112 +/- 47 pg/10(6) mDCs, n = 3) levels were detectable only after 24 hours of incubation. After adding IL-10-neutralizing antibody, TNF-alpha Fc epsilon RI-dependent responses were significantly augmented (3903 +/- 197 pg/10(6) mDCs, P RI-mediated TNF-alpha responses up to 86% +/- 3% (n = 3, P RI-dependent secretion of IL-10 by 3.2-fold (183 +/- 11 pg/10(6) mDCs, n = 4) compared with that seen in untreated cells (57 +/- 33 pg/10(6) mDCs, P RI-dependent IL-10 secretion by mDCs was similarly augmented by 3-fold. Autocrine secretion of IL-10, a critical autoregulator of Fc epsilon RI-dependent proinflammatory responses in mDCs, is cross-regulated by IFN-alpha, a major product of Toll-like receptor 9 responses in pDCs that normally promotes T(H)1 immunity.

  20. Analysis of Degree 5 Chordal Rings for Network Topologies

    DEFF Research Database (Denmark)

    Riaz, M. Tahir; Pedersen, Jens Myrup; Bujnowski, Sławomir

    2011-01-01

    This paper presents an analysis of degree 5 chordal rings, from a network topology point of view. The chordal rings are mainly evaluated with respect to average distance and diameter. We derive approximation expressions for the related ideal graphs, and show that these matches the real chordal ri...

  1. Functional characterization of the high affinity IgG Receptor : making heads and tails of FcγRI

    NARCIS (Netherlands)

    van der Poel, C.E.

    2011-01-01

    This thesis focuses on human FcγRI, a high affinity receptor for antibodies of the IgG isotype. IgG is the most abundant antibody type in blood and all currently FDA approved therapeutic antibodies are of the IgG isotype. FcγRI, a member of the activating Fcγ receptors, exists as a complex of a

  2. Orai and TRPC channel characterization in FcεRI-mediated calcium signaling and mediator secretion in human mast cells.

    Science.gov (United States)

    Wajdner, Hannah E; Farrington, Jasmine; Barnard, Claire; Peachell, Peter T; Schnackenberg, Christine G; Marino, Joseph P; Xu, Xiaoping; Affleck, Karen; Begg, Malcolm; Seward, Elizabeth P

    2017-03-01

    Inappropriate activation of mast cells via the FcεRI receptor leads to the release of inflammatory mediators and symptoms of allergic disease. Calcium influx is a critical regulator of mast cell signaling and is required for exocytosis of preformed mediators and for synthesis of eicosanoids, cytokines and chemokines. Studies in rodent and human mast cells have identified Orai calcium channels as key contributors to FcεRI-initiated mediator release. However, until now the role of TRPC calcium channels in FcεRI-mediated human mast cell signaling has not been published. Here, we show evidence for the expression of Orai 1,2, and 3 and TRPC1 and 6 in primary human lung mast cells and the LAD2 human mast cell line but, we only find evidence of functional contribution of Orai and not TRPC channels to FcεRI-mediated calcium entry. Calcium imaging experiments, utilizing an Orai selective antagonist (Synta66) showed the contribution of Orai to FcεRI-mediated signaling in human mast cells. Although, the use of a TRPC3/6 selective antagonist and agonist (GSK-3503A and GSK-2934A, respectively) did not reveal evidence for TRPC6 contribution to FcεRI-mediated calcium signaling in human mast cells. Similarly, inactivation of STIM1-regulated TRPC1 in human mast cells (as tested by transfecting cells with STIM1-KK684-685EE - TRPC1 gating mutant) failed to alter FcεRI-mediated calcium signaling in LAD2 human mast cells. Mediator release assays confirm that FcεRI-mediated calcium influx through Orai is necessary for histamine and TNFα release but is differentially involved in the generation of cytokines and eicosanoids. © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

  3. Qualitative evidence of Ri specific IgG-synthesis in the cerebrospinal fluid from patients with paraneoplastic neurological syndromes.

    Science.gov (United States)

    Jarius, S; Stich, O; Rasiah, C; Voltz, R; Rauer, S

    2008-05-15

    The presence of Ri-specific oligoclonal IgG bands in the CSF was investigated in five patients with paraneoplastic anti-Ri associated neurological syndromes (PNS) and six controls. In 4/5 CSF samples reactivity of IgG bands with recombinant Ri antigen was found using isoelectrofocusing combined with affinity blotting; in one patient with absence of oligoclonal bands of total IgG in CSF Ri-specific oligoclonal bands were detected with the same sample, indicating a higher sensitivity of Ri-specific affinity blotting as compared to affinity blotting with anti-human IgG antibodies. Our results confirm previous studies demonstrating IgG synthesis against onconeuronal antigens by intrathecal B-cell clones in PNS and extend this observation to patients with anti-Ri syndrome. The pathogenic relevance of these antibodies, however, is further challenged by the finding that specific intrathecal IgG synthesis might not be a prerequisite of CNS involvement, because it was missed in one of our patients.

  4. Eluruumi üürniku õiguste kaitse üüri ühepoolse suurendamise ja ebamõistliku suuruse korral : [bakalaureusetöö] / Martin Kalberg ; Tartu Ülikooli Õigusinstituut ; juhendaja: Kalev Saare

    Index Scriptorium Estoniae

    Kalberg, Martin

    2006-01-01

    Üüri suuruse ajalooline ülevaade ja võrdlus, üüri suurus eluruumi üürilepingu olulise osana, üüri ühepoolse suurendamise võimalused, üürniku vaidlustamisvõimalused üüri suurendamise korral

  5. Probing the function of individual amino acid residues in the DNA binding site of the EcoRI restriction endonuclease by analysing the toxicity of genetically engineered mutants.

    Science.gov (United States)

    Oelgeschläger, T; Geiger, R; Rüter, T; Alves, J; Fliess, A; Pingoud, A

    1990-04-30

    We have developed an assay that allows analysis of the activity of EcoRI restriction endonuclease (ENase) and its mutants in vivo. This assay is based on the fact that wild type (wt) EcoRI ENase is toxic for Escherichia coli cells not expressing the EcoRI methyltransferase (MTase). The viability factor defined by the ratio of the viable counts of E. coli cultures having or not having expressed the ecoRIR gene for a defined time is 10(-6) for wt EcoRI ENase and close to one for a totally inactive EcoRI ENase mutant. While the EcoRI MTase (M.EcoRI) provides substantial protection against the toxic effects of the wt EcoRI ENase and several of the mutants, some mutants become more toxic in the presence of M.EcoRI. Twenty-four different DNA-binding-site mutants of EcoRI ENase were characterized in their activity in vivo with this assay. The results obtained allow us to conclude that the structural integrity of the region at and around aa 200 seems to be very critical for the enzymatic function of EcoRI ENase: nonconservative replacements there lead to viability factors of 1-10(-2). While our results indicate that the region around aa 144 and 145 is also involved in the EcoRI ENase-catalyzed reaction, it is also evident that the effects of mutation there are not as large: viability factors of approx. 10(-3) are obtained even for drastic replacements. These results are discussed in the light of the x-ray structure analysis of an EcoRI ENase-DNA recognition complex.

  6. Asia Rice Crop Estimation and Monitoring (Asia-RiCE) for GEOGLAM

    Science.gov (United States)

    Oyoshi, K.; Tomiyama, N.; Okumura, T.; Sobue, S.

    2013-12-01

    Food security is a critical issue for the international community because of rapid population and economic growth, and climate change. In June 2011, the meeting of G20 agriculture ministers was held to discuss food security and food price volatility, and they agreed on an 'Action Plan on Food Price Volatility and Agriculture'. This plan includes a GEO Global Agricultural Monitoring (GEOGLAM) initiative. The aim of GEOGLAM is to reinforce the international community's ability to produce and disseminate relevant, timely, and accurate forecasts of agricultural production on regional, national, and global scales by utilizing remote sensing technology. GEOGLAM focused on four major grain crops, wheat, maize, soybeans and rice. In particular, Asian countries are responsible for approximately 90% of the world rice production and consumption, rice is the most significant cereal crop in Asian region. Hence, Asian space and agricultural agencies with an interest in the development of rice crop monitoring technology launched an Asia-Rice Crop Estimation & Monitoring (Asia-RiCE) component for the GEOGLAM initiative. In Asian region, rice is mainly cultivated in rainy season, and a large amount of cloud limits rice crop monitoring with optical sensors. But, Synthetic Aperture RADAR (SAR) is all-weather sensor and can observe land surface even if the area is covered by cloud. Therefore, SAR technology would be powerful tool to monitor rice crop in Asian region. Asia-RiCE team required mainly SAR observation data including ALOS-2, RISAT-1, Sentinel-1 and RADARSAT, TerraSAR-X, COSMO-SkyMed for Asia-RiCE GEOGLAM Phase 1 implementation (2013-2015) to the Committee on Earth Observations (CEOS) in the GEOGLAM-CEOS Global Agricultural Monitoring Co-community Meeting held in June 2013. And also, rice crop has complicated cropping systems such as rein-fed or irrigated cultivation, single, double or sometimes triple cropping. In addition, each agricultural field is smaller than that of

  7. ANALISA PENERIMAAN PENERAPAN TEKNIK AUDIT BERBANTUAN KOMPUTER (TABK DENGAN MENGGUNAKAN TECHNOLOGY ACCEPTANCE MODEL (TAM PADA BADAN PEMERIKSA KEUANGAN (BPK RI

    Directory of Open Access Journals (Sweden)

    Natalia Tangke

    2004-01-01

    Full Text Available This research intends to reveal factors that influence the auditor of BPK RI to accept the apllying of Computer Assisted Audit Techniques (CAATs, if evaluated by using Technology Acceptance Model (TAM. Statistical tools used in this research is Structural Equation Model (SEM. Data are anayzed by using statistical software LISREL 8.30. This research proved that factor influenced the acceptance of applying TABK in BPK RI is perceived usefulness of TABK (PU and perceived ease of use of TABK (PEOU indirectly influenced the acceptance of applying TABK in BPK RI. From this research it was also proved that the attitude factor toward using TABK (ATT do not influence the decision of auditor of BPK RI to accept the applying of TABK. and attitude toward using TABK (ATT is not influenced by perceived usefulness of TABK (PU. Abstract in Bahasa Indonesia : Penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi penerimaan auditor BPK RI terhadap penerapan Teknik Audit Berbantuan Komputer (TABK, dengan menggunakan Technology Acceptance Model (TAM. Uji statistik yang digunakan adalah Structural Equation Model (SEM. Data dianalisis dengan menggunakan bantuan perangkat lunak LISREL 8.30. Penelitian ini berhasil membuktikan bahwa faktor yang mempengaruhi penerimaan penerapan TABK di BPK RI adalah persepsi pengguna tentang kegunaan TABK (PU dan secara tidak langsung oleh persepsi pengguna tentang kemudahan dalam menggunakan TABK (PEOU. Penelitian ini juga membuktikan, faktor sikap pengguna terhadap penggunaan TABK (ATT tidak mempengaruhi keputusan auditor BPK RI untuk menerima penerapan TABK dan sikap pengguna terhadap penggunaan TABK (ATT tidak dipengaruhi oleh persepsi pengguna tentang kegunaan TABK (PU. Kata kunci: Teknik Audit Berbantuan Komputer (TABK, Technology Acceptance Model (TAM, persepsi pengguna, sikap pengguna terhadap penggunaan (ATT, dan penerimaan pengguna (ACC.

  8. Fyn kinase controls Fc{epsilon}RI receptor-operated calcium entry necessary for full degranulation in mast cells

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez-Miranda, Elizabeth; Ibarra-Sanchez, Alfredo [Departamento de Farmacobiologia, Centro de Investigacion y de Estudios Avanzados (Cinvestav), Sede Sur, Calzada de los Tenorios 235, Col. Granjas Coapa, CP 14330 Mexico City (Mexico); Gonzalez-Espinosa, Claudia, E-mail: cgonzal@cinvestav.mx [Departamento de Farmacobiologia, Centro de Investigacion y de Estudios Avanzados (Cinvestav), Sede Sur, Calzada de los Tenorios 235, Col. Granjas Coapa, CP 14330 Mexico City (Mexico)

    2010-01-22

    IgE-antigen-dependent crosslinking of the high affinity IgE receptor (Fc{epsilon}RI) on mast cells leads to degranulation, leukotriene synthesis and cytokine production. Calcium (Ca{sup 2+}) mobilization is a sine qua non requisite for degranulation, allowing the rapid secretion of stored pro-inflammatory mediators responsible for allergy symptoms. Fyn is a Src-family kinase that positively controls Fc{epsilon}RI-induced mast cell degranulation. However, our understanding of the mechanism connecting Fyn activation to secretion of pre-synthesized mediators is very limited. We analyzed Fc{epsilon}RI-dependent Ca{sup 2+} mobilization in bone marrow-derived mast cells (BMMCs) differentiated from WT and Fyn -/- knock out mice. Fyn -/- BMMCs showed a marked defect in extracellular Ca{sup 2+} influx after Fc{epsilon}RI crosslinking but not after thapsigargin addition. High concentrations of Gadolinium (Gd{sup 3+}) partially blocked Fc{epsilon}RI-induced Ca{sup 2+} influx in WT cells but, in contrast, completely inhibited Ca{sup 2+} mobilization in Fyn -/- cells. Low concentrations of an inhibitor of the canonical transient receptor potential (TRPC) Ca{sup 2+} channels (2-aminoethoxyphenyl-borane, 2-APB) blocked Fc{epsilon}RI-induced maximal Ca{sup 2+} rise in WT but not in Fyn -/- cells. Ca{sup 2+} entry through Fyn-controlled, 2-APB sensitive channels was found to be important for full degranulation and IL-2 mRNA accumulation in WT cells. Immunoprecipitation assays showed that Fyn kinase interacts with TRPC 3/6/7 channels after IgE-antigen stimulation, but its association is not related to protein tyrosine phosphorylation. Results indicate Fyn kinase mediates the receptor-dependent activation of TRPC channels that contribute to degranulation in Fc{epsilon}RI-stimulated mast cells.

  9. t-Darpp stimulates protein kinase A activity by forming a complex with its RI regulatory subunit.

    Science.gov (United States)

    Theile, Dirk; Geng, Shuhui; Denny, Erin C; Momand, Jamil; Kane, Susan E

    2017-12-01

    t-Darpp is the truncated form of the dopamine- and cAMP-regulated phosphoprotein of 32kDa (Darpp-32) and has been demonstrated to confer resistance to trastuzumab, a Her2-targeted anticancer agent, via sustained signaling through the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/Akt pathway and activation of protein kinase A (PKA). The mechanism of t-Darpp-mediated PKA activation is poorly understood. In the PKA holoenzyme, when the catalytic subunits are bound to regulatory subunits RI or RII, kinase activity is inhibited. We investigated PKA activity and holoenzyme composition in cell lines overexpressing t-Darpp (SK.tDp) or a T39A phosphorylation mutant (SK.tDpT39A), as well as an empty vector control cell line (SK.empty). We also evaluated protein-protein interactions between t-Darpp and PKA catalytic (PKAc) or regulatory subunits RI and RII in those cell lines. SK.tDp cells had elevated PKA activity and showed diminished association of RI with PKAc, whereas SK.tDpT39A cells did not have these properties. Moreover, wild type t-Darpp associates with RI. Concurrent expression of Darpp-32 reversed t-Darrp's effects on PKA holoenzyme state, consistent with earlier observations that Darpp-32 reverses t-Darpp's activation of PKA. Together, t-Darpp phosphorylation at T39 seems to be crucial for t-Darpp-mediated PKA activation and this activation appears to occur through an association with RI and sequestering of RI away from PKAc. The t-Darpp-RI interaction could be a druggable target to reduce PKA activity in drug-resistant cancer. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. Päästjate palk tõuseb nii nagu lubatud / Jüri Pihl

    Index Scriptorium Estoniae

    Pihl, Jüri, 1954-

    2007-01-01

    Ilmunud ka: Järva Teataja, 6. nov. 2007, lk. 2; Valgamaalane, 6. nov. 2007, lk. 2; Vooremaa, 6. nov. 2007, lk. 2; Põhjarannik, 6. nov. 2007, lk. 4; Vali Uudised, 7. nov. 2007, lk. 2; Sakala, 8. nov. 2007, lk. 2; Severnoje Poberezhje, 8. nov. 2007, lk. 2; Koit, 8. nov. 2007, lk. 6; Sõnumitooja, 14. nov. 2007, lk. 2. Siseminister Jüri Pihl lükkab ümber Keskerakonna väited, et päästeametnike palk ei tõuse ja kinnitab palgatõusu toimumist vastavalt riigieelarve seaduse eelnõule

  11. Äriõigus 2008 : seaduste tekstid seisuga 01. 09. 2008 / koost. ja komment. Andrus Lauren

    Index Scriptorium Estoniae

    2008-01-01

    Kaanel sisu: Äriseadustik. Tulundusühistuseadus. TsÜS. Euroopa äriühingu (SE) määrus. SE määruse RS. Töötajate kaasamise seadus. Euroopa ühistu (SCE) määrus. SCE määruse RS. EMHÜ määrus. EMHÜ määruse RS. Konkurentsiseadus. Majandustegevuse registri seadus. Väärtpaberite keskregistri seadus. Raamatupidamise seadus. Rahapesu tõkestamise seadus. Audiitortegevuse seadus. Pankrotiseadus. - Kommentaarid lk. 365-388

  12. RI plethysmography in the early evaluation of preoperative treatment for malignant bone tumors

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Seiichi; Kawaguchi, Tomoyoshi; Manabe, Jun; Kuroda, Hiroshi; Oyamada, Hiyoshimaru; Yamada, Yasuhiko (Japanese Foundation for Cancer Research, Tokyo (Japan). Hospital); Furuya, Kotaro; Isobe, Yasushi

    1992-01-01

    RI plethysmography with Tc-99m human serum albumin was performed to determine the effectiveness of preoperative chemotherapy performed in 14 patients with malignant bone tumor. It failed to detect blood changes before and after chemotherapy in 2 patients with bone tumor of telangiectatic type. In the other 12 patients, changes in blood flow during the process of treatment were depicted on plethysmograms. It preceded the other techniques for chemotherapeutic evaluation in 2 patients. It was considered useful in the early evaluation of chemotherapy, if combined with other imaging examinations to detect morphological changes. (N.K.).

  13. Cardiomyopathie du péri-partum prise en charge en milieu ...

    African Journals Online (AJOL)

    Cardiomyopathie du péri-partum prise en charge en milieu Hospitalier Universitaire de Bobo-Dioulasso : aspects thérapeutiques et évolutifs. S. J-B. Tougouma, A.A. Yaméogo, A. Dembélé, G. Kinda, N.V. Yaméogo, G.R.C. Millogo, J.K. Kologo, A. Héma, Y. Kambiré, L. Savadogo, M.S. Ouédraogo, P. Zabsonré ...

  14. Puugravüüriklotsid kõnelevad / Jüri Hain

    Index Scriptorium Estoniae

    Hain, Jüri, 1941-

    2007-01-01

    Näitus "Sajand eesti puugravüüri klotsidel Eesti Rahvusraamatukogu kollektsioonist" rahvusraamatukogus 15. I - 3. II. Näitusel on vanim klots aastast 1842, noorim 1941. aastast. Kunstnikest (Aleksander Otto Gern, Bogdan Gottlieb Friedrich Kally, August Daugell, Eduard Magnus Jakobson, Mart Pukits, Andres Kuusk, Anton Suurkask, Arkadio Laigo, Hando Mugasto, Eduard Järv, Paul Liivak, Salome Trei, Ott Kangilaski), töödest. Näitust täiendavad Eduard Wiiralti "Tüdruku pea" (1919) kaks linoollõikeplaati

  15. Turvalist kooliaastat - koolis, tänaval ja internetis / Jüri Pihl

    Index Scriptorium Estoniae

    Pihl, Jüri, 1954-

    2008-01-01

    Ilmunud ka: Molodjozh Estonii 1. sept. lk. 4-5, Sakala 2. sept., lk. 2, Virumaa Teataja 2. sept., lk. 11, Oma Saar 2. sept., lk. 5, Tartu Postimees 2. sept., lk. 2, Hiiu Leht 2. sept., lk. 2, Pärnu Postimees 2. sept., lk. 15, Koit 2. sept. lk. 6, Sõnumitooja 3. sept. lk. 2, Vooremaa 4. sept. lk. 2. Siseminister Jüri Pihl esitab kolm suuremat probleemi, mis vähendavad turvalisust koolis ja kooliteel: ohud liikluses, kasvav meelemürkide tarvitamine ning koolivägivald

  16. Interjööri kujunduse ja moekunsti seosed ja vastasmõjud / Jane Kukk

    Index Scriptorium Estoniae

    Kukk, Jane

    2011-01-01

    Teoreetilise uurimuse eesmärgiks oli vaadelda disaini laiemalt, kõrvutades moe- ja interjööridisaini, looduskeskkonna, sotsiaalpoliitilise ja kultuuriruumi mõjutusi sellele ning jõudes järeldusele, et kõik disaini valdkonnad on tänu disainimise protsessi samale mudelile sarnased, on omavahel seotud ja võivad üksteist mõjutada, eriti tingimustes, kus moetööstus on laiendanud oma tegevust interjööri valdkonda, soovides luua terviklikku elustiili paketti tänapäeva tarbimisühiskonnas

  17. O movimento RastafÃri: da Jamaica para identidade e cultura em Fortaleza.

    OpenAIRE

    DÃbora Andrade Pamplona Bezerra

    2012-01-01

    Esta pesquisa explora e descreve como o movimento RastafÃri tem se manifestado em Fortaleza, CearÃ. ApÃs um abrangente panorama do movimento conforme se originou na Jamaica, busquei caracterizar a diversidade da cultura e da organizaÃÃo do viver de alguns adeptos residentes em Fortaleza, comparando-os com aspectos gerais do movimento na Jamaica. Busquei tambÃm apontar para traÃos das suas vivÃncias que possam ter sido influenciados pela cultura e identidade brasileiras e cearenses. Adotando c...

  18. Genetic characterization and ligand specificity of the ovine Fc gamma receptor I (ovFc gamma RI).

    Science.gov (United States)

    Qiao, Songlin; Liu, Yunchao; Zhang, Jiuliang; Yang, Suzhen; Wan, Bo; Shi, Pingling; Zhang, Hong; Guo, Junqing; Zhang, Gaiping

    2010-10-15

    Receptors for the Fc region of IgG (Fc gamma Rs) play a critical role in the immune system and host protection against infection. In this study, we describe the cloning, mRNA expression and IgG subclass specificity of ovine Fc gamma receptor I (ovFc gamma RI). The ovFc gamma RI cDNA contains a 1047bp open-reading frame, and is predicted to encode a 349 amino acid trans-membrane glycoprotein composed of three immunoglobulin-like domains, a trans-membrane region and a short cytoplasmic tail. The overall identity of the ovine Fc gamma RI to its cattle, human and mouse counterparts at the level of the amino acid sequence was 92%, 61% and 54%, respectively. Rosetting analysis shows that COS-7 cells were transfected with an expressional vector carrying the cDNA open-reading frame of ovFc gamma RI and expressed this receptor on the surface. Identification of ovine Fc gamma RI will aid in the understanding of molecular basis of the ovine immune system and further studies of the receptor function. (c) 2010 Elsevier B.V. All rights reserved.

  19. Protein 4.1G binds to a unique motif within the Fc gamma RI cytoplasmic tail.

    Science.gov (United States)

    Beekman, Jeffrey M; Bakema, Jantine E; van der Poel, Cees E; van der Linden, Joke A; van de Winkel, Jan G J; Leusen, Jeanette H W

    2008-04-01

    The C-terminal domain of protein 4.1G was identified to interact with the cytosolic tail of the high affinity IgG receptor, Fc gamma RI, in yeast two-hybrid screens. Proteins of the 4.1 family have previously been found to mediate receptor/cytoskeleton interactions. In the study presented here, we show an alternatively spliced 4.1G product to be associated with increased Fc gamma RI binding in yeast two-hybrid assays, and to be selectively enriched in most immune cells at the transcript level. In addition, a detailed analysis of the 4.1G 'docking site' within Fc gamma RI is provided by examining Fc gamma RI-CY-truncated and alanine-substituted mutants. These pointed to an Fc gamma RI membrane-proximal core motif of HxxBxxxBB (H represents hydrophobic residues, B basic residues and x represents any residue), followed by hydrophobic and (potentially) negatively charged residues to be central for interaction with protein 4.1G.

  20. Ion-optical studies of BigRIPS separator and ZeroDegree spectrometer at RIKEN RI Beam Factory

    Science.gov (United States)

    Takeda, Hiroyuki; Kubo, Toshiyuki; Ohnishi, Tetsuya; Fukuda, Naoki; Kameda, Daisuke; Kusaka, Kensuke; Yoshida, Atsushi; Yoshida, Koichi; Ohtake, Masao; Inabe, Naohito; Yanagisawa, Yoshiyuki; Tanaka, Kanenobu; Matsushita, Masafumi

    2009-10-01

    The BigRIPS in-flight separator[1] and the ZeroDegree spectrometer (ZDS) have been commissioned at RIKEN RI Beam Factory (RIBF) recently. Intense radioactive isotope (RI) beams are produced, separated and analyzed by the BigRIPS and the ZDS. Both of them are operated in several optical modes according to experimental conditions. For particle identifications of RI beams, it is essentially important to achieve high resolutions in A/Q ratio because RI beams are produced in several charge states in our energy region especially for heavy RI beams. Ion optical calculation with realistic magnetic field maps is indispensable for our purpose and we use COSY INFINITY[2] for that. Measured field maps are incorporated in the COSY calculations. In 2008, the ZDS was commissioned for the first time in three different modes. Experimental results and comparison with the COSY calculations will be presented in this report. [1]T. Kubo: Nucl. Instr. Meth. B204, 97 (2003). [2]K. Makino, M. Berz: Nucl. Instr. Meth. A558, 346 (2006).

  1. Püha Jüri võitlus kapitalistliku hüdraga / Priit Hõbemägi, Andrei Hvostov

    Index Scriptorium Estoniae

    Hõbemägi, Priit, 1957-

    2009-01-01

    SDE uus esimees Jüri Pihl teatas, et sotsiaaldemokraatidel on alternatiiv seni valitsenud neoliberaalsele ideoloogiale. Autorite hinnangul hakkab J. Pihli vastasseis Reformierakonnaga olema hoopis teistsugune kui Keskerakonnaga

  2. Evaluation of RI images of hepatic blood flow using Tc-99m PMT

    Energy Technology Data Exchange (ETDEWEB)

    Fujiwara, Hiromichi; Iwasaki, Naoya; Ichikawa, Kesato

    1988-03-01

    To evaluate the clinical significance of RI images of hepatic blood flow using Tc-99m-PMT, analysis of the RI images and estimation of hepatic blood flow were carried out in patients with various liver diseases (37 cases). After intravenous injection of Tc-99m-PMT, hepatic accumulation curve of ROI positioned at whole liver area and time activity curve of ROI positioned at celiac artery were obtained through scintillation camera images with the computer-analysed system. Hepatic blood flow coefficient (K) was calculated from the hepatic accumulation curve. Based on the differential curve calculated from the time activity curve, chronological images of arterial, portal, parenchymal and saturated parenchymal phases were obtained. Results ; 1) K was 0.50 + 0.04, 0.35 + 0.02 and 0.26 + 0.04/min in normal type, CH type and LC type respectively. These coefficients well correlated with clinical severity of hepatic diseases. 2) Perfusional phase images of the liver became poorer in accordance with progression of liver disease, while images of spleen, portal venous system and collateral channels were more clearly obtained in liver cirrhosis. This method was shown to have a potential to understanding of severity of liver disease and hepatic blood flow dynamics.

  3. Feasibility study on RI biochip Application to detection of risk factors of atherosclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Ko, Kyong Cheol; Choi, Mi Hee; Park, Sang Hyun [Korea Atomic Energy Research Institte, Jeongeup (Korea, Republic of); Cho, Kyung Hyun [Yeungnam University, Gyeongsan (Korea, Republic of); Lee, Ki Teak [Chungnam National University, Daejeon (Korea, Republic of)

    2009-03-15

    Microarrays can be used to screen thousands of binding events in a parallel and high throughput fashion and are of major importance in discase diagnosis and drug discovery. The use of radioisotope is conventionally regarded as one of the most sensitive detection methods. Atherosclerosis is a common disorder affecting arterial blood vessels. It happens when fat, cholesterol, and other substances made in the arterial blood vessels form a hard substances called plaque. Lipoprotein-associated phospholipase A{sub 2} (Lp-PLA{sub 2}), a phospholipase A{sub 2} enzyme, is used as a marker for cardiac disease. The detection of Lp-PLA{sub 2} was accomplished by using radioactive [{sup 3}H-acetyl] PAF as a substrate and a feasibility study on RI biochip application to detection of Lp-PLA{sub 2}, a risk factors of atherosclerosis was performed. Inhibitive activity of a native plant extract was also determined by using the RI biochip. It was found to be applicable to a high-throughput screening of inhibitors for developing atherosclerosis therapeutic agents.

  4. Strongyloides ratti: implication of mast cell-mediated expulsion through FcεRI-independent mechanisms

    Directory of Open Access Journals (Sweden)

    Watanabe K.

    2009-09-01

    Full Text Available In order to examine whether FcεRI-dependent degranulation of intestinal mast cells is required for expulsion of intestinal nematode Strongyloides ratti, CD45 exon6-deficient (CD45-/- mice were inoculated with S. ratti. In CD45-/- mice, egg excretion in feces persisted for more than 30 days following S. ratti larvae inoculation, whereas in wild-type (CD45+/+ mice, the eggs completely disappeared by day 20 post-infection. The number of intestinal mucosal mast cells, which are known effector cells for the expulsion of S. ratti, was 75% lower in CD45-/- mice compared with that in CD45+/+ mice. Adoptive transfer of wild-type T cells from CD45+/+ mice into CD45-/- mice reduced the duration of S. ratti infection to comparable levels observed in CD45+/+ mice, with concomitant increases in intestinal mucosal mast cells. These results showed that CD45 is not involved in the effector function of intestinal mucosal mast cells against S. ratti infection. Since FcεRI-dependent degranulation of mast cells is completely impaired in these CD45 knockout mice, we conclude that FcεRIdependent degranulation is not required in the protective function of intestinal mucosal mast cells against primary infection of S. ratti.

  5. Insights into copper coordination in the EcoRI-DNA complex by ESR spectroscopy

    Science.gov (United States)

    Ji, Ming; Tan, Likun; Jen-Jacobson, Linda; Saxena, Sunil

    2014-12-01

    The EcoRI restriction endonuclease requires one divalent metal ion in each of two symmetrical and identical catalytic sites to catalyse double-strand DNA cleavage. Recently, we showed that Cu2+ binds outside the catalytic sites to a pair of new sites at H114 in each sub-unit, and inhibits Mg2+-catalysed DNA cleavage. In order to provide more detailed structural information on this new metal ion binding site, we performed W-band (∼94 GHz) and X-band (∼9.5 GHz) electron spin resonance spectroscopic measurements on the EcoRI-DNA-(Cu2+)2 complex. Cu2+ binding results in two distinct components with different gzz and Azz values. X-band electron spin echo envelope modulation results indicate that both components arise from a Cu2+ coordinated to histidine. This observation is further confirmed by the hyperfine sub-level correlation results. W-band electron nuclear double resonance spectra provide evidence for equatorial coordination of water molecules to the Cu2+ ions.

  6. Time-of-flight detector applied to mass measurements in Rare-RI Ring

    Energy Technology Data Exchange (ETDEWEB)

    Nagae, D., E-mail: nagae@tac.tsukuba.ac.jp [Institute of Physics, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571 (Japan); Abe, Y. [Institute of Physics, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571 (Japan); RIKEN Nishina Center, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Okada, S.; Ozawa, A. [Institute of Physics, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571 (Japan); Yamaguchi, T. [Department of Physics, Saitama University, Shimo-Okubo 255, Sakura-ku Saitama-shi, 338-8570 (Japan); Suzuki, H.; Moriguchi, T. [Institute of Physics, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571 (Japan); Ishibashi, Y. [Institute of Physics, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571 (Japan); RIKEN Nishina Center, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Fukuoka, S.; Nishikiori, R.; Niwa, T. [Institute of Physics, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571 (Japan); Suzuki, T.; Suzaki, F.; Sato, K.; Furuki, H.; Ichihashi, N.; Miyazawa, S. [Department of Physics, Saitama University, Shimo-Okubo 255, Sakura-ku Saitama-shi, 338-8570 (Japan); Yamaguchi, Y.; Uesaka, T.; Wakasugi, M. [RIKEN Nishina Center, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)

    2013-12-15

    Highlights: • We have developed Time-of-flight detectors for the Rare-RI Ring. • Measurements to evaluate a time resolution and a detection efficiency have been performed using alpha particle and heavy ion beams. • Preliminary time resolution is about 130 ps and detection efficiency is about 56% for the heavy ion beams. -- Abstract: A large time-of-flight (TOF) detector has been developed for the Rare-RI Ring. This detector consists of a Multi Channel Plate (MCP) and a carbon foil. Secondary electrons from the carbon foil are transported to the MCP by crossed electric and magnetic fields. In order to cover the beam size of the ring, a large and thin carbon foil (100 mm × 50 mm{sup 2} and 60 μg/cm{sup 2}) is used as a sensitive material. The time resolution of σ≈130 ps, the detection efficiency about 56% and a position dependence of the TOF about 1 ns are obtained. A calculated position dependence of TOF adopting experimental (inhomogeneous) electric field and a homogeneous magnetic field is in agreement with the experimental one. These results suggest that the homogeneity of electric field is important to improve the time resolution in the large size detector.

  7. Feasibility Study of Economics and Performance of Solar Photovoltaics at the TechCity East Campus Resource Conservation and Recovery Act Site in Kingston, New York. A Study Prepared in Partnership with the Environmental Protection Agency for the RE-Powering America's Land Initiative: Siting Renewable Energy on Potentially Contaminated Land and Mine Sites

    Energy Technology Data Exchange (ETDEWEB)

    Salasovich, James [National Renewable Energy Lab. (NREL), Golden, CO (United States); Geiger, Jesse W. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Mosey, Gail [National Renewable Energy Lab. (NREL), Golden, CO (United States); Healey, Victoria [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2014-01-01

    The U.S. Environmental Protection Agency (EPA), in accordance with the RE-Powering America's Land initiative, selected the TechCity East Campus site in Kingston, New York, for a feasibility study of renewable energy production. The National Renewable Energy Laboratory (NREL) provided technical assistance for this project. The purpose of this study is to assess the site for a possible photovoltaic (PV) system installation and estimate the cost, performance, and site impacts of different PV options. In addition, the report recommends financing options that could assist in the implementation of a PV system at the site.

  8. Substance P downregulates expression of the high affinity IgE receptor (FcepsilonRI) by human mast cells.

    Science.gov (United States)

    McCary, Christine; Tancowny, Brian P; Catalli, Adriana; Grammer, Leslie C; Harris, Kathleen E; Schleimer, Robert P; Kulka, Marianna

    2010-03-30

    The effect of the neuropeptide substance P (SP) on human mast cell (MC) phenotype is poorly understood. In this study, SP effects on human MC expression of the high affinity IgE receptor (FcepsilonRI) were characterized. SP downregulated expression of FcepsilonRI mRNA and protein by approximately 50% and in a concentration dependent manner, the effect was partially mediated by engagement of the neurokinin-1 receptor (NK1R) and resulted in reduced mast cell activation. Sensitization of MC with IgE prior to SP exposure protected MC from SP-mediated FcepsilonRI downregulation. SP release may inhibit MC responses to allergens and these results may have implications in neuroinflammatiion and stress. Crown Copyright 2010. Published by Elsevier B.V. All rights reserved.

  9. Substance P downregulates expression of the high affinity IgE receptor (FcεRI) by human mast cells

    Science.gov (United States)

    McCary, Christine; Tancowny, Brian P.; Catalli, Adriana; Grammer, Leslie C.; Harris, Kathleen E.; Schleimer, Robert P.; Kulka, Marianna

    2013-01-01

    The effect of the neuropeptide substance P (SP) on human mast cell (MC) phenotype is poorly understood. In this study, SP effects on human MC expression of the high affinity IgE receptor (FcεRI) were characterized. SP downregulated expression of FcεRI mRNA and protein by approximately 50% and in a concentration dependent manner, the effect was partially mediated by engagement of the neurokinin-1 receptor (NK1R) and resulted in reduced mast cell activation. Sensitization of MC with IgE prior to SP exposure protected MC from SP-mediated FcεRI downregulation. SP release may inhibit MC responses to allergens and these results may have implications in neuroinflammatiion and stress. PMID:20117843

  10. RiVax, a recombinant ricin subunit vaccine, protects mice against ricin delivered by gavage or aerosol

    Science.gov (United States)

    Smallshaw, Joan E.; Richardson, James A.; Vitetta, Ellen S.

    2007-01-01

    Ricin is a plant toxin that is a CDC level B biothreat. Our recombinant ricin A chain vaccine (RiVax), which contains mutations in both known toxic sites, has no residual toxicity at doses at least 800 times the immunogenic dose. RiVax without adjuvant given intramuscularly (i.m.) protected mice against intraperitoneally administered ricin. Furthermore the vaccine without alum was safe and immunogenic in human volunteers. Here we describe the development of gavage and aerosol ricin challenge models in mice and demonstrate that i.m. vaccination protects mice against ricin delivered by either route. Also RiVax protects against aerosol-induced lung damage as determined by histology and lung function tests. PMID:17875350

  11. The WD40 Domain of HIRA Is Essential for RI-nucleosome Assembly in Xenopus Egg Extracts.

    Science.gov (United States)

    Zhu, Ruibin; Iwabuchi, Mari; Ohsumi, Keita

    2017-01-01

    Histone chaperones are a group of histone-binding proteins that facilitate the assembly of nucleosomes, the fundamental structural units of chromatin in eukaryotes. In nucleosome assembly, deposition of a histone H3-H4 tetramer onto DNA is the first and critical step, which is mediated by the histone chaperones HIRA and CAF-1. HIRA and CAF-1 are reportedly involved in DNA replication independent (RI) and replication coupled nucleosome assembly, respectively. However, the mechanisms by which they mediate histone deposition remain unclear. In this study, we focused on the mechanism by which HIRA induces RI-nucleosome assembly. We looked for HIRA domains that are required for nucleosome assembly and its localization to chromatin. We used cell-free extracts from Xenopus eggs that carry out RI-nucleosome assembly of plasmid DNA. We confirmed that HIRA formed stable complexes with Asf1, another histone H3-H4 chaperone, and the HIRA-Asf1 complex was solely responsible for RI-nucleosome assembly in egg extracts. We further demonstrated that the HIRA N-terminus containing the WD40 domain, which comprises seven WD40 repeats, and the B domain, to which Asf1 binds, were essential for RI-nucleosome assembly; the three WD40 repeats from the N-terminus were especially critical. Using egg extracts that reproduce nuclear formation accompanying the duplication of chromatin, we also demonstrated that the Hir domain was indispensable for the binding of HIRA to chromatin. Thus, the WD40 and B domains are the core elements for inducing RI-nucleosome assembly. Hir domain regulates the binding to chromatin. Based on these findings, similarities and differences between HIRA and CAF-1 are discussed.

  12. The Rhode Island Consortium for Autism Research and Treatment (RI-CART): a new statewide autism collaborative.

    Science.gov (United States)

    Gerber, Alan; Morrow, Eric; Sheinkopf, Stephen J; Anders, Thomas

    2014-05-01

    Autism is a neurodevelopmental disorder characterized by core deficits in social interaction, language and repetitive behaviors. The need for services is rising sharply as the number of children identified with autism increases. The Rhode Island Consortium for Autism Research and Treatment (RI-CART) was founded in 2009 with the goal of increasing communication among autism researchers throughout the state and improving treatment for children with autism. RI-CART members have several exciting projects in progress, with its larger aim being the creation of a statewide research registry. A statewide registry would benefit research in Rhode Island and allow for larger collaborations nationally.

  13. Research on treatment and disposal of RI and Research Institute Waste. Progress in Department of Fuel Cycle Safety Research

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    Department of Fuel Cycle Safety Research, JAERI, has been carrying out research on safe and rational disposal systems of radioactive wastes arising from medical activities and research institutes (RI and Research Institute Waste). The research area includes a study on molten solidified waste form, a geological survey on Japan, a proposal on integrated disposal systems, data acquisition for safety evaluation, and a safety analysis of disposal systems. This report introduces progress and future works for the treatment and disposal of RI and Research Institute Waste. (author)

  14. Study on α-cluster levels in non-4n nuclei using low-energy RI beams

    Science.gov (United States)

    Yamaguchi, H.; Kahl, D.; Hayakawa, S.; Sakaguchi, Y.; Abe, K.; Nakao, T.; Suhara, T.; Iwasa, N.; Kim, A.; Kim, D. H.; Cha, S. M.; Kwag, M. S.; Lee, J. H.; Lee, E. J.; Chae, K. Y.; Wakabayashi, Y.; Imai, N.; Kitamura, N.; Lee, P.; Moon, J. Y.; Lee, K. B.; Akers, C.; Jung, H. S.; Duy, N. N.; Khiem, L. H.; Lee, C. S.

    2017-06-01

    Alpha resonant scattering is a simple and promising method to study α-cluster structure in nuclei. It has several good features which enable us to perform measurements with short-lived and relatively low-intense RI beams. Several measurements on alpha resonant scattering have been carried out at CRIB (CNS Radioactive Ion Beam separator), which is a low-energy RI beam separator at Center for Nuclear Study (CNS) of the University of Tokyo. Recent α resonant scattering studies at CRIB, using7Li,7Be and10Be beams with a helium gas target, are discussed.

  15. ri Sillart: Hea film on kui õhkõrn orhidee või maavillane parmupill : [2003. a. ilmunud artikli oluliselt täiendatud versioon] / Jüri Sillart ; intervjueerinud Margus Mikomägi

    Index Scriptorium Estoniae

    Sillart, Jüri, 1943-2011

    2013-01-01

    Filmirežissöör, -operaator ja Tallinna Ülikooli filmipedagoog eesti filmist ja enda omadest veidi lähemalt. 29. mail oleks Jüri Sillart saanud 70-aastaseks. Ka tema endiste õpilaste Elari Lendi ja Madis Reimundi meenutused

  16. Development of new auxiliary basis functions of the Karlsruhe segmented contracted basis sets including diffuse basis functions (def2-SVPD, def2-TZVPPD, and def2-QVPPD) for RI-MP2 and RI-CC calculations.

    Science.gov (United States)

    Hellweg, Arnim; Rappoport, Dmitrij

    2015-01-14

    We report optimized auxiliary basis sets for use with the Karlsruhe segmented contracted basis sets including moderately diffuse basis functions (Rappoport and Furche, J. Chem. Phys., 2010, 133, 134105) in resolution-of-the-identity (RI) post-self-consistent field (post-SCF) computations for the elements H-Rn (except lanthanides). The errors of the RI approximation using optimized auxiliary basis sets are analyzed on a comprehensive test set of molecules containing the most common oxidation states of each element and do not exceed those of the corresponding unaugmented basis sets. During these studies an unsatisfying performance of the def2-SVP and def2-QZVPP auxiliary basis sets for Barium was found and improved sets are provided. We establish the versatility of the def2-SVPD, def2-TZVPPD, and def2-QZVPPD basis sets for RI-MP2 and RI-CC (coupled-cluster) energy and property calculations. The influence of diffuse basis functions on correlation energy, basis set superposition error, atomic electron affinity, dipole moments, and computational timings is evaluated at different levels of theory using benchmark sets and showcase examples.

  17. Äriühingute rahvusvaheline ühinemine : [bakalaureusetöö] / Anu Tehver ; Tartu Ülikool, õigusteaduskond ; juhendaja: Andres Vutt

    Index Scriptorium Estoniae

    Tehver, Anu

    2000-01-01

    Ühinemine ja ülevõtmine ühe äriühingu poolt teises äriühingus kontrolli omandamise viisidena, ühinemise rahvusvaheline regulatsioon - Euroopa Liidu direktiivid, reguleerimine Eestis, rahvusvahelise ühinemise läbiviimine, maksustamine, töötajate õigused, ühinemise kontroll

  18. Cytokine-induced immune complex binding to the high-affinity IgG receptor, FcγRI, in the presence of monomeric IgG

    NARCIS (Netherlands)

    van der Poel, C.E.; Karssemeijer, R.A.; Boross, P.; van der Linden, J.A.; Blokland - Fromme, M.; van de Winkel, J.G.J.; Leusen, J.H.W.

    2010-01-01

    FcγRI is the sole high-affinity immunoglobulin G (IgG) receptor on leukocytes. Its role in immunity and the clearance of opsonized particles has been challenged, as the receptor function may well be hindered by serum IgG. Here, we document immune complex binding by FcγRI to be readily enhanced by

  19. 78 FR 19024 - Submission for Review: It's Time to Sign Up for Direct Deposit or Direct Express, RI 38-128

    Science.gov (United States)

    2013-03-28

    ... From the Federal Register Online via the Government Publishing Office OFFICE OF PERSONNEL MANAGEMENT Submission for Review: It's Time to Sign Up for Direct Deposit or Direct Express, RI 38-128 AGENCY... INFORMATION: RI 38-128 is primarily used by OPM to give recent retirees the opportunity to waive Direct...

  20. RI-002, an intravenous immunoglobulin containing high titer neutralizing antibody to RSV and other respiratory viruses for use in primary immunodeficiency disease and other immune compromised populations.

    Science.gov (United States)

    Wasserman, Richard L; Greener, Benjamin N; Mond, James

    2017-10-16

    Novel immune globulin (IG) products (RI-002, RI-001) have been designed to provide protection against respiratory syncytial virus (RSV) mediated respiratory illness while at the same time meeting the manufacturing requirements established by FDA for antibody supplementation in immunocompromised subjects. Areas covered: This review covers the manufacture and development of both RI-001 and RI-002, including the selection of plasma donors for IG preparation with high-titers of anti-RSV antibody, in vitro, and preclinical data in the cotton rat model S. hispidus, and clinical trials including Phase II and compassionate use studies of RI-001 and a multi-center, pivotal Phase III study of RI-002 in PIDD patients. Expert commentary: The data demonstrate that RI-002 is efficacious in the prevention and treatment of RSV in preclinical normal and immune suppressed animal models and is safe and efficacious in the treatment of patients with various forms of primary immunodeficiency disease (PIDD). This product offers potential advantages over other available IG's for prophylaxis in immunocompromised patients requiring polyclonal immunoglobulin supplementation because of its unique antibody composition. In addition to its enhanced neutralizing anti-RSV activity and its polyclonal IG composition, there is preclinical data to support the use of RI-002 for humoral protection against other respiratory pathogens.

  1. Aktsionäri infoõigus : [bakalaureusetöö] / Henri Parisalu ; Tartu Ülikool, õigusteaduskond ; juhendaja: Andres Vutt

    Index Scriptorium Estoniae

    Parisalu, Henri

    2009-01-01

    Aktsionäri infoõiguse eesmärkidest ja funktsioonidest, olemusest ja sisust mittebörsiühingutes ning börsiühingutes, siseriiklike ja rahvusvaheliste organisatsioonide mõjust aktsionäri infoõigusele

  2. Riigieksamitulemuste kümneprotsendine vahe - on seda vähe või palju? / Ellu Rusi, Lauri Leesi, Jüri Vanajuur, Heikki Järlik

    Index Scriptorium Estoniae

    2012-01-01

    Küsimusele vastasid Türi ühisgümnaasiumi direktori kt Ellu Rusi, Tallinna prantsuse lütseumi direktor Lauri Leesi, Vinni-Pajusti gümnaasiumi direktor Jüri Vanajuur, Tsirguliina keskkooli direktor Heikki Järlik

  3. Design and construction of drift tube linac cavities for RIKEN RI Beam Factory

    Science.gov (United States)

    Suda, K.; Sakamoto, N.; Yamada, K.; Arai, S.; Chiba, Y.; Kase, M.; Okuno, H.; Watanabe, Y.; Kamigaito, O.

    2013-09-01

    A new injector linac "RILAC2", has recently been constructed at the RIKEN RI Beam Factory. The main part of the RILAC2 is a drift tube linac that consists of three newly designed cavities. These cavities operate in continuous wave (CW) mode at a fixed frequency of 36.5 MHz. Their structure is based on a quarter-wavelength resonator because this is the smallest resonator available in this frequency range among the available structures. We adopted the direct coupling method in the construction of these cavities. A power amplifier was directly coupled to the cavity without a long transmission line to reduce the installation area and simultaneously reduce construction cost. A detailed cavity and coupler design was carried out via simulation. Our work also describes the design process using three-dimensional electromagnetic simulation software. Construction and operation tests are also shown.

  4. 7th International Conference on Robotics in Education (RiE)

    CERN Document Server

    Lepuschitz, Wilfried; Koppensteiner, Gottfried; Balogh, Richard

    2017-01-01

    This proceedings volume showcases the latest achievements in research and development in Educational Robotics presented at the 7th International Conference on Robotics in Education (RiE) held in Vienna, Austria, during April 14-15, 2016. The book offers a range of methodologies for teaching robotics and presents various educational robotics curricula. It includes dedicated chapters for the design and analysis of learning environments as well as evaluation means for measuring the impact of robotics on the students’ learning success. Moreover, the book presents interesting programming approaches as well as new applications, the latest tools, systems and components for using robotics. The presented applications cover the whole educative range, from elementary school to high school, college, university and beyond, for continuing education and possibly outreach and workforce development. The book provides a framework involving two complementary kinds of contributions: on the one hand on technical aspects and on ...

  5. Concurrent inhibition of kit- and FcepsilonRI-mediated signaling: coordinated suppression of mast cell activation

    DEFF Research Database (Denmark)

    Jensen, Bettina M; Beaven, Michael A; Iwaki, Shoko

    2008-01-01

    Although primarily required for the growth, differentiation, and survival of mast cells, Kit ligand (stem cell factor) is also required for optimal antigen-mediated mast cell activation. Therefore, concurrent inhibition of Kit- and FcepsilonRI-mediated signaling would be an attractive approach...... for targeting mast cell-driven allergic reactions. To explore this concept, we examined the effects of hypothemycin, a molecule that we identified as having such properties, in human and mouse mast cells. Hypothemycin blocked Kit activation and Kit-mediated mast cell adhesion in a similar manner to the well...... for a coordinated approach for the suppression of mast cell activation and provide a rationale for the development of compounds with a similar therapeutic profile....

  6. The mosaic genome structure of the Wolbachia wRi strain infecting Drosophila simulans

    DEFF Research Database (Denmark)

    Klasson, Lisa; Westberg, Joakim; Sapountzis, Panagiotis

    2009-01-01

    genome of W. pipientis strain wRi that induces very strong cytoplasmic incompatibility in its natural host Drosophila simulans. A comparison with the previously sequenced genome of W. pipientis strain wMel from Drosophila melanogaster identified 35 breakpoints associated with mobile elements and repeated......-group Wolbachia strains uncovered the most highly recombining intracellular bacterial genomes known to date. This was manifested in a 500-fold variation in sequence divergences at synonymous sites, with different genes and gene segments supporting different strain relationships. The substitution-frequency profile...... of horizontal gene transfer across A- and B-group strains that infect D. simulans. These results suggest that the transmission dynamics of Wolbachia and the opportunity for coinfections have created a freely recombining intracellular bacterial community with mosaic genomes....

  7. Strengthening the infrastructure for RI applications in cooperation with the IAEA

    Energy Technology Data Exchange (ETDEWEB)

    Park, Kyung Bae; Hong, Young Don; Kim, Seung Yun; Kim, Kyoung Pyo; Lee, Jeong Kong

    2000-12-01

    The future direction for nuclear cooperation should be implemented with the aim of enhancing the status of Korea within the international society as well as carrying out the established national nuclear policy goal. Strategies for implementing cooperation with the IAEA were described into four separate parts; 'strategies for strengthening cooperation in general areas', 'strategies for implementing IAEA technical cooperation programs', 'strategies for implementing IAEA CRP programs' and 'Strategies for effective participation in the area of radiation and RI application'. As for strategies for implementing IAEA technical cooperation programs, i) expanding domestic personnel's entering into the IAEA ii) establishment of a liaison office for support of IAEA technical cooperation iii) expanding domestic experts entering into member of consultation group for a director-general of the IAEA and more participation in the international meetings iv) cooperation with IAEA's Seibersdorf Laboratories. For the strengthening of IAEA technical cooperation, strategies for effective implementation of technical cooperation programs such as i) strengthening role of national TC liaison officer ii) strengthening application of Model Project concept iii) Implementing End-user oriented programs iv) Establishment of measure to increase the TC implementation rate v) hosting of fellowship, scientific visitors, support for expert mission, were presented. Strategies for expanding domestic participation in the IAEA technical cooperation programs were also described for producing the benefits from implementing the IAEA technical cooperation programs. As for strategies for implementing the IAEA CRP programs, i) measures for active participation in the IAEA CRP programs and ii) measures for gradual participation in the IAEA CRP programs were separately described. To maximize the utilization of HANARO, a multi-purpose research reactor, the on

  8. Pulmonary blood volume measured by RI angiocardiography. Comparison between mitral valve disease and other diseases

    Energy Technology Data Exchange (ETDEWEB)

    Ono, Kazuo (Fukushima Medical Coll. (Japan))

    1982-08-01

    RI angiocardiography (RACG) was performed in 81 patients with heart disease without congestive heart failure at the time, and the results were compared between the groups with mitral valve disease and other diseases. Cardiac output (CO) and pulmonary mean transit time (PMTT) were compared with the results from the dye dilution method in the same patients. PMTT directly measured by RACG was also compared with the peak to peak time (P-PT). P-PT was expressed as the distance from the right to the left peak time in radiocardiography (RCG). There were good correlations between the CO and PMTT obtained from the RI method and those of the dye dilution method (r = 0.90, r = 0.84). The relationship between PMTT and P-PT in mitral valve disease was different from that of other diseases. The average value of PMTT was 5.2 +- 1.0 seconds, and pulmonary blood volume (PBV) was 315 +- 57 ml/m/sup 2/ in the control group. The PBV values were markedly increased in patients with mitral stenosis (558 +- 132 ml/m/sup 2/) and mitral regurgitation (444 +- 119 ml/m/sup 2/), and were slightly increased in aortic valve disease, congenital shunt disease and cardiomyopathy. The patients with ischemic heart disease had normal PBV. In mitral valve disease, the direct method using PMTT of RACG is more accurate than the presumption method using P-PT of RCG. The determination of PBV by this method is very important to observe hemodynamic states in mitral valve disease.

  9. Research reactor systems for the stable and efficient supply of RI

    Energy Technology Data Exchange (ETDEWEB)

    Lim, In Choel; Oh, Sooy Oul; Lee, Choong Sung; Jun, Byung Jin [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2009-04-15

    The supply of medical isotopes has relied on the major four research reactors over the world and an unavailability of some of these reactors caused a problem in the stable supply of medical isotopes, especially {sup 9}9{sup M}o. There are several ways to produce {sup 9}9{sup M}o but is is believed that the use of a research reactor is the most efficient way. There are two ways to produce {sup 9}9{sup M}o in a research reactor; they are the separation of {sup 9}9{sup M}o from the fission product and the use of neutron capture reaction of {sup 9}8{sup M}o. For the former, various ways are available depending on the target morphology and the enrichment of uranium in the target. The efficiency of the neutron capture method depends on the available neutron flux, the enrichment of {sup 9}8{sup M}o in the target and the efficiency of the adsorption column. Besides these nuclear engineering aspects, other issues affect the use of the research reactor and they include the following; the on power loading of the target, the methods to reduce the cost for the production of RI in research reactors, the logistics between the producer and the consumer, and the coalition of research reactors. In addition, the producers of RI products or the distributors should become the prosumers in the production of sources. The stable and efficient supply of medical isotopes is believed to depend on all these factors and the future options on the use of a research reactor in Korea for the medical isotope supply should consider these.

  10. An integration-free, virus-free rhesus macaque induced pluripotent stem cell line (riPSC89 from embryonic fibroblasts

    Directory of Open Access Journals (Sweden)

    Enrique Sosa

    2016-09-01

    Full Text Available We generated a rhesus macaque induced pluripotent stem cell (riPSC line, riPSC89, from rhesus embryonic fibroblasts (REFs. Fibroblasts were expanded from the skin of a rhesus macaque embryo at embryonic day 47. REFs and riPSCs had a normal male (42, XY karyotype. The riPSC89 line was positive for markers of self-renewal including OCT4, NANOG, TRA-1-81 and SSEA4. Pluripotency was demonstrated through the generation of teratomas using transplantation into immunocompromised mice. The riPSC89 line may be a useful non-human primate resource to uncover developmental origins of disease, or used as a basic model to understand lineage specification in the primate embryo.

  11. Performance on the RI-48 Cued Recall Test Best Predicts Conversion to Dementia at the 5- and 10-Year Follow-Ups.

    Science.gov (United States)

    Hanseeuw, Bernard; Ivanoiu, Adrian

    2011-01-01

    TheRI-48 cued recall test was devised to discriminate between healthy elderly and patients with mild cognitive impairment who are at risk of developing Alzheimer's disease (AD). However, no long-term follow-up studies have been conducted using this test. We analyzed the predictive power of the RI-48 test for determining the patients who will convert to AD dementia within the decade after testing. During 10 years, we followed up 40 non-demented patients who attended our Memory Clinic and underwent complete neuropsychological evaluation including the RI-48. Of the 40 patients, 21 developed dementia (converters, CO) and 19 remained stable patients (SP). Of the tests performed at inclusion, only the RI-48 (p RI-48 had the best overall diagnostic accuracy at 5- and at 10-year follow-ups.

  12. Kaug-Ida autoäri eripärast - sae kas või maastur pooleks / Jaanus Piirsalu

    Index Scriptorium Estoniae

    Piirsalu, Jaanus, 1973-

    2010-01-01

    2009. a. tõsteti Venemaal sisseveetavate kasutatud autode tollimakse. Nüüd saetakse Vladivostokki teel olevad kasutatud autod Jaapanis pooleks ja tuuakse üle piiri kui varuosad. Poolitatud autod keevitatakse Vladivostokis taas kokku. Kasutatud autode äri on Kaug-Idas vähenenud kümneid kordi

  13. 77 FR 14032 - John H. Chafee Coastal Barrier Resources System; Lee County, FL, and Newport County, RI...

    Science.gov (United States)

    2012-03-08

    ... Service received a request in 2004 to review CBRS Unit RI-05P. When the Service finds a technical mapping... to revisit the same map in the future. In accordance with this comprehensive mapping approach, the... stakeholders concerning the availability of the draft revised maps: the Chair and Ranking Member of the House...

  14. Optimaalse haridusmudeli poole / Tõnis Lukas, Andres Jõgar, Jüri Ojamaa...[jt.] ; üles kirjutanud Karl Kello

    Index Scriptorium Estoniae

    2009-01-01

    Tartus 3. aprillil toimunud ümarlaua vestlusest, millest võttis osa haridus- ja teadusminister Tõnis Lukas, Kõrvküla Põhikooli direktor Andres Jõgar, Abja Gümnaasiumi direktor Jüri Ojamaa, Nõo vallavanem Rain Sangernebo ja Tartu haridusosakonna juhataja Boris Goldman

  15. Pihl : joobes autojuhtimised pole liikluses probleem number üks / Jüri Pihl ; interv. Peeter Kuimet

    Index Scriptorium Estoniae

    Pihl, Jüri, 1954-

    2007-01-01

    Siseminister Jüri Pihl vastab küsimustele liiklusõnnetuste ja -surmade põhjuste kohta, pidades suurimaks põhjuseks kiiruseületamist ja lahtisi turvavöid. Rikkujate karistamisest ja alkoholimüügi piirangutest. Lisa: Kurb statistika

  16. Consideration of the direction for improving RI-biomics information system for using big data in radiation field

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seung Hyun; Kim, Joo Yeon; Park, Tai Jin [Korean Association for Radiation Application, Seoul (Korea, Republic of); Lim, Young Khi [Dept. of Radiological Science, Gachon University, Incheon (Korea, Republic of)

    2017-03-15

    RI-Biomics is a fusion technology in radiation felds for evaluating in-vivo dynamics such as absorption, distribution, metabolism and excretion (RI-ADME) of new drugs and materials using radioisotopes and quantitative evaluation of their effcacy. RI-Biomics information is being provided by RIBio-Info developed as information system for distributing its information and three requirements for improving RIBio-Info system have been derived through reviewing recent big data trends in this study. Three requirements are defined as resource, technology and manpower, and some reviews for applying big data in RIBio-In system are suggested. Fist, applicable external big data have to be obtained, second, some infrastructures for realizing applying big data to be expanded, and finally, data scientists able to analyze large scale of information to be trained. Therefore, an original technology driven to analyze for atypical and large scale of data can be created and this stated technology can contribute to obtain a basis to create a new value in RI-Biomics feld.

  17. Narratives of Agency: The Experiences of Braille Literacy Practitioners in the "Kha Ri Gude" South African Mass Literacy Campaign

    Science.gov (United States)

    McKay, Veronica I.; Romm, Norma R. A.

    2015-01-01

    In this article, we locate the "Kha Ri Gude" South African Mass Literacy Campaign within the context of the problem of illiteracy and exclusion in South Africa, while concentrating on various post-apartheid initiatives designed to give visually challenged adults the opportunity to become literate. We shall provide a detailed account of…

  18. Millega seostub teil sõna "integratsioon"? / Olev Lipp, Sergei Ptšjolkin, Jüri Toit...[jt.

    Index Scriptorium Estoniae

    2009-01-01

    Küsimusele vastavad: Kunda Ühisgümnaasiumi direktor Olev Lipp, Mustjõe Gümnaasiumi füüsikaõpetaja Sergei Ptšjolkin, Jõgeva Ühisgümnaasiumi direktor Jüri Toit, Helsingi Ülikooli doktorant Ivar Tröner, Tallinna Tõnismäe Reaalkooli matemaatikaõpetaja Mihhail Gusev

  19. Uudised : Hooaja lõppkontsert. Tallinna Kammerorkester lõpetab hooaja. Tüüri autorikontsert New Yorgis / Leelo Kõlar

    Index Scriptorium Estoniae

    Kõlar, Leelo, 1927-

    2000-01-01

    Täna toimuvast Eesti Kontserdi hooaja lõppkontserdist, kus tuleb ettekandele G. Mahleri 3. sümfoonia. Tallinna Kammerorkestri hooaja viimasest kontserdist sarjas "Mozart +" 20. ja 21. mail. 12. mail andis Absolute Ensemble K. Järvi juhatusel sarja "Heliloojate portreed" raames kontserdi E.-S. Tüüri loomingust

  20. Vil! Jüri Uluotsa ümbermatmine : Kirbla kirikus ja kalmistul 31. augustil 2008 / Rein Grabbi

    Index Scriptorium Estoniae

    Grabbi, Rein, 1934-

    2009-01-01

    Eesti peaministri presidendi ülesannetes eksiilis Jüri Uluotsa ja tema lähedaste põrmud toodi Eestisse ja maeti 31. augustil 2008 auavalduste saatel perekonna hauaplatsile Kirblasse. Matusetalitusel pidas kõne president Toomas Hendrik Ilves

  1. Fluorescence stopped-flow kinetics of the cleavage of synthetic oligodeoxynucleotides by the EcoRI restriction endonuclease.

    Science.gov (United States)

    Alves, J; Urbanke, C; Fliess, A; Maass, G; Pingoud, A

    1989-09-19

    We have investigated in fluorescence stopped-flow and temperature-jump experiments the EcoRI-catalyzed cleavage of synthetic palindromic tridecadeoxynucleotides which contain the EcoRI site but differ in the flanking sequences. The overall reaction can be resolved in several reactions which were analyzed by a nonlinear least-squares fitting procedure on the experimental data. The result of this analysis is a minimal scheme that describes the overall reaction in terms of the rate constants of the individual reactions. According to this scheme EcoRI and the tridecadeoxynucleotide substrates associate in the presence of Mg2+ in a nearly diffusion-controlled process. This is followed by a reaction which is or includes the cleavage of the first phosphodiester bond. There is no indication for a time-resolved conformational transition prior to catalysis. After cleavage of the first strand, dissociation of the nicked double strand can occur, which then rearranges to the original palindromic double-stranded substrate and is bound again by the enzyme. Alternatively, the nicked double strand can be cleaved in the second strand. This reaction is followed by product release from the enzyme. The magnitude of the individual rate constants depends on the substrate used; the differences explain the preference of EcoRI for substrates that contain AT as compared to GC base pairs next to the recognition site.

  2. Aktsionäri kahju hüvitamise nõue aktsiaseltsi ja selle juhtorgani liikmete vastu / Margit Vutt

    Index Scriptorium Estoniae

    Vutt, Margit, 1968-

    2012-01-01

    Aktsionäri kahju hüvitamise nõudest rahalise jm kohustuse rikkumise korral. Aktsiaseltsi ja juhtorgani liikmete deliktiõiguslikust vastutusest. Juhtorgani liikmete vastutusest ühinemisel ja jagunemisel. Eesti ja Saksa õiguse ja kohtupraktika võrdlev analüüs

  3. Üle 36 000 pensionäri ei ole saanud 856 eurot, millele neil oleks õigus / Tuuli Jõesaar

    Index Scriptorium Estoniae

    Jõesaar, Tuuli

    2011-01-01

    36 273 mittetöötavat pensionäri pole esitanud avaldust tulumaksuvabastuse saamiseks, seetõttu on neilt 2010. a. ebaõiglaselt sisse kasseeritud kokku vähemalt 10 mln. eurot tulumaksu. Paljud pensionärid pole tulumaksuvabastuse võimalusest teadlikud. Diagramm

  4. 76 FR 50771 - Submission for Review: RI 25-37, Evidence To Prove Dependency of a Child, 3206-0206

    Science.gov (United States)

    2011-08-16

    ... MANAGEMENT Submission for Review: RI 25-37, Evidence To Prove Dependency of a Child, 3206-0206 AGENCY: U.S... Dependency of a Child. As required by the Paperwork Reduction Act of 1995 (Pub. L. 104-13, 44 U.S.C. chapter.... SUPPLEMENTARY INFORMATION: Evidence to Prove Dependency of a Child is designed to collect sufficient information...

  5. Maarjamäe loss (Marienberg) / Robert Gödicke, Nikolai vanem Thamm, Jüri Renter

    Index Scriptorium Estoniae

    Gödicke, Robert

    2004-01-01

    5 välisvaadet, üks 1930. aastast; mõisa ajaloost, omanikest, lossi arhitektuurist, interjöörist, pargist; 1975. a. anti loss üle Eesti Ajaloomuuseumile; hoone restaureeriti aastatel 1983-88 (arhitekt Jüri Renter, sisearhitekt Helle Gans)

  6. Baltische Rechtswissenschaftsgeschichte : Professor Jüri Uluots (1890-1945) in seiner und unserer Zeit = Baltijas tiesibu vestures zinatne : profesors Jiri Uluotss (1890-1945) toreiz un musu laikos = The scholarship of history of law in the Baltics

    Index Scriptorium Estoniae

    Järvelaid, Peeter, 1957-

    2008-01-01

    Lisatud: Publikationen von Professor Jüri Uluots / koost. Maia Ruttu, Karmen Visnapuu, lk. 86-91 ; Publikationen über Professor Jüri Uluots 1925-2000 / koost. Maia Ruttu, Karmen Visnapuu, lk. 91-93

  7. Functional Proteomic Analysis of Signaling Networks and Response to Targeted Therapy

    Science.gov (United States)

    2009-03-01

    Jordan JD, Landau EM, Iyengar R (2000) Signaling networks: the origins of cellular multitasking. Cell 103: 193–200. 53. Eungdamrong NJ, Iyengar R...I, Shamir R (2009) Identifying functional modules using expression profiles and confidence-scored protein interactions. Bioinformatics 25: 1158–1164

  8. Sammas ja labürint: Jüri Ehlvesti tekstuaalsest ruumist. Column and Labyrinth: On Jüri Ehlvest’s Textual Space

    Directory of Open Access Journals (Sweden)

    Virve Sarapik

    2012-04-01

    Full Text Available The purpose of this article is to analyze the connections of spatial relations and settings with narrative, and the presentation of these relations in Jüri Ehlvest’s texts. Distinctions are made between textual space (as designation, description, or rhetorical presentation and fictional space (the space in which narrative action takes place and the site of the denouement of events. Fictional space can be expressed as textual space in one of the four following ways: (a perceived space (b experienced space (c logical space (d alogical space. The multilayeredness of Ehlvest’s texts, their fragmentariness and dislocated reality, entail a complicated reception. In contrast, however, the geographical space represented in the texts is generally quite clear and accessible, with the effect of seeming real and humanly possible. Indeed, specific spatial elements are one of the sources of the verisimilitude and plausibility of Ehlvest’s texts. For the most part, the place where ehlvestian narrative plays itself out is a clear topographical environment, usually an interior; the textual representation of spaces is minimalist, avoiding descriptions, and with practically no impression of movement. In addition to representation of places, rooms, houses, and open space using ordinary, direct, (yet very minimalist means, several more indirect strategies of creating space can be found in Ehlvest’s texts. This article calls attention to some characteristic devices from this indirect repertoire, grouping them as follows: things; window and picture; repetition, fragment, and mirror; body and emptiness. Of the four types of textual space mentioned above, the one most characteristic of Ehlvest’s stories is experienced space, which could also be described as haptic space of experience. However, due to the fragmentariness and bricolage typical of Ehlvest, there are certainly also plenty of examples of the other types, particularly perceived and alogical space

  9. Äriühinguõiguse ühtlustamine Euroopa Liidus ja selle mõju Eesti õigusele : [magistritöö] / Greete-Kristiine Kuru ; Tartu Ülikool, õigusteaduskond ; juhendaja: Andres Vutt

    Index Scriptorium Estoniae

    Kuru, Greete-Kristiine, 1989-

    2013-01-01

    Äriühinguõiguse ühtlustamise alustest ja läbiviimisest Euroopa Liidus, äriühingute piiriülesest asukohavahetusest Euroopa Liidus, äriühingute piiriülese ühinemise regulatsioonist Euroopa Liidus

  10. Europlanet-RI: Access to Planetary Data, Tools, Models and Support Information

    Science.gov (United States)

    Schmidt, W.; Capria, M. T.; Chanteur, G.

    2012-04-01

    information is collected in the data access system of IDIS. By the end of the project in 2012 data from most planetary missions can be accessed, combined and correlated with spectral data bases for atmospheric gases and solids, laboratory measurements related to space observations and the results of model runs simulating the observations of different parameters around and at planets under various boundary conditions. The VO-structure will allow the access to these data through graphical interfaces including optimized visualization tools or alternatively through a command interface for further integration into other applications. Reference: [1] Details to IDIS and the Europlanet-RI via Web-site: http://www.idis.europlanet-ri.eu/ [2] Demonstrator implementation for Plasma-VO AMDA: http://cdpp-amda.cesr.fr/DDHTML/index.html [3] Demonstrator implementation for the IDIS-VO: http://www.idis-dyn.europlanet-ri.eu/vodev.shtml

  11. Characterization of dendritic cell phenotype in allergic conjunctiva: increased expression of Fc(epsilon)RI, the high-affinity receptor for immunoglobulin E.

    Science.gov (United States)

    Manzouri, B; Ohbayashi, M; Leonardi, A; Larkin, D F P; Ono, S J

    2009-11-01

    Dendritic cells (DCs) express the high-affinity receptor for IgE (Fc(epsilon)RI) on their surface, which may enhance their ability to capture and internalize antigens for presentation to T-lymphocytes. The aim of this study was to determine if expression of Fc(epsilon)RI(+) DCs is increased in the conjunctivae of vernal keratoconjunctivitis (VKC) patients compared with those of normal controls. Conjunctival biopsies were obtained from non-atopic and VKC patients. Double immunohistochemical staining was carried out using antibodies against Fc(epsilon)RI and the CD1a antigen, a DC marker. The double-positive cells were counted in five representative fields of view for each conjunctival sample. Fc(epsilon)RI(+) CD1a(+) cells were present in significantly higher numbers in VKC conjunctivae compared with normal controls (mean cell count of 21.3 in VKC vs5.0 in controls, PRI-expressing DCs tended to be confined to the epithelial layer or the superficial substantia propria, but in the VKC samples these Fc(epsilon)RI(+) cells were mainly concentrated in the deeper substantia propria. Fc(epsilon)RI(+) DC numbers are elevated in the conjunctivae of VKC patients, a finding consistent with the results of other studies focusing on atopic conditions. Elevated expression of Fc(epsilon)RI on DCs would facilitate antigen presentation and enhance T-cell priming, thereby contributing to ocular symptoms.

  12. 3-D Modeling and Resources Estimation of Ilmenite Ore Bodies in Jikjeon-Ri, Hadong, Korea

    Science.gov (United States)

    Kwak, J.; Choi, J.; Cho, H.

    2013-12-01

    The Hadong area, located in central south of Korea, is famous for well-developed ilmenite ores deposited in the Precambrian anorthositic rocks. Ti ores are several lodes of vein types which discontinuously extend few kilometers along NNE in strike and NW in dip. For efficient exploitation of the mineral resources, 3D modeling of ore bodies are relevantly required to evaluate the exact amount of resources. This study aims at description and 3D representation of ilmenite ore bodies in Jikjeon-Ri, Hadong, using GOCAD software. To facilitate 3D model construction, initial datasets consist of a contour map, well-logging data, and Ti grades of 50 cm interval of wells. Ilmenite shows 1.5~25.1 wt% of Ti in composition. These datasets are imported into GOCAD, where construction of ore bodies are built in 3D. Geostatistics is a common tool for resouces estimation. Kriging method, one of the geostatistics, is applied to 3D modeling and resources estimation of ilmenite ores in the study area, for kriging is very effective in resources. For further calculation, two variogram models (spherical and exponential) are considered and more fitting variogram models are selected to estimate ilmenite resources correctly. The results of 3D construction show five lodes of ilmenite bodies developed in Jikjeon-Ri area as stratiform vein types. Top ilmenite lode (designated as 1st ore body) is estimated 1,393,730 m3 in volume and 2.56 wt% of average Ti grade. The 2nd ore body is smallest and 181,260 m3 in volume and 2.68 wt% in average Ti grade. The others are 186,700 m3 and 4.73 wt%, 209,260 m3 and 3.17 wt%, and 527,180 m3 and 3.81 wt% in volume and average Ti grades, respectively. From these calculations, resources of total ilmenite ores in the study area are estimated 228,261 tons of Ti, which has a value of 1,552.2 million in US (6.8 US/kg).

  13. On preparatory causal factors, initiating the prehistoric Tsergo Ri landslide (Langthang Himal, Nepal)

    Science.gov (United States)

    Weidinger, Johannes Thomas; Schramm, Josef-Michael; Surenian, Rouben

    1996-07-01

    The most probable series of causal factors and their complexity make analysis and synthesis of the Tsergo Ri landslide (Langthang Himal, central-north Nepal) restricted, especially in this case of a prehistoric event with a spread of age data. Interpreting morphologic, lithologic, structural and engineering-geologic aspects in relation to preparatory causal factors and subsequent processes will therefore be only an approach. The solid basement and the broken crest of the landslide, as well as the surrounding areas of the upper section of Langthang valley, are to be included in the High Himalayan Crystalline: leucogranitic dikes (dipping towards the southwest) intruded gneisses and migmatites (primary foliation towards the northeast). Formation of these dikes caused one of many factors or preexisting structures, leading to the development of the landslide. In addition, subsequent tectonic movements and related seismicity forced specific deformation of metamorphic rocks: ultramylonites, two generations of faults with striated slickensides, and pseudotachylites degraded to substantial horizons of weakness. The spatial orientation enabled predetermination of subsequent morphologic processes (e.g., slope destabilising forces, trend and dip of sliding). In association with leucogranitic intrusions, a disseminated mineralized, extensive sulphidic ore structure outcrops at the broken crest of the landslide. Due to brittle rheologic behaviour and poor weathering resistance this ore-bearing horizon (parallel to the main sliding plane) also made the slopes susceptible to sliding. Material displaced from the scarp by landsliding, was mixed up with rocks from undisturbed ground and subsequently cemented by secondary ore mineralization, thus forming ore-breccias at the top of the surface of rupture. Neotectonic structures, caused by stress release associated with erosional processes and similarly oriented as the existing zones of weakness, may have acted as a preparatory and

  14. Common solutions for power, communication and robustness in operations of large measurement networks within Research Infrastructures

    Science.gov (United States)

    Huber, Robert; Beranzoli, Laura; Fiebig, Markus; Gilbert, Olivier; Laj, Paolo; Mazzola, Mauro; Paris, Jean-Daniel; Pedersen, Helle; Stocker, Markus; Vitale, Vito; Waldmann, Christoph

    2017-04-01

    European Environmental Research Infrastructures (RI) frequently comprise in situ observatories from large-scale networks of platforms or sites to local networks of various sensors. Network operation is usually a cumbersome aspect of these RIs facing specific technological problems related to operations in remote areas, maintenance of the network, transmission of observation values, etc.. Robust inter-connection within and across these networks is still at infancy level and the burden increases with remoteness of the station, harshness of environmental conditions, and unavailability of classic communication systems, which is a common feature here. Despite existing RIs having developed ad-hoc solutions to overcome specific problems and innovative technologies becoming available, no common approach yet exists. Within the European project ENVRIplus, a dedicated work package aims to stimulate common network operation technologies and approaches in terms of power supply and storage, robustness, and data transmission. Major objectives of this task are to review existing technologies and RI requirements, propose innovative solutions and evaluate the standardization potential prior to wider deployment across networks. Focus areas within these efforts are: improving energy production and storage units, testing robustness of RI equipment towards extreme conditions as well as methodologies for robust data transmission. We will introduce current project activities which are coordinated at various levels including the engineering as well as the data management perspective, and explain how environmental RIs can benefit from the developments.

  15. Bayesian network as a modelling tool for risk management in agriculture

    DEFF Research Database (Denmark)

    Rasmussen, Svend; Madsen, Anders Læsø; Lund, Mogens

    The importance of risk management increases as farmers become more exposed to risk. But risk management is a difficult topic because income risk is the result of the complex interaction of multiple risk factors combined with the effect of an increasing array of possible risk management tools....... In this paper we use Bayesian networks as an integrated modelling approach for representing uncertainty and analysing risk management in agriculture. It is shown how historical farm account data may be efficiently used to estimate conditional probabilities, which are the core elements in Bayesian network models....... We further show how the Bayesian network model RiBay is used for stochastic simulation of farm income, and we demonstrate how RiBay can be used to simulate risk management at the farm level. It is concluded that the key strength of a Bayesian network is the transparency of assumptions...

  16. Surface Disturbances at the Punggye-ri Nuclear Test Site: Another Indicator of Nuclear Testing?

    Energy Technology Data Exchange (ETDEWEB)

    Pabian, Frank V. [Los Alamos National Laboratory; Coblentz, David [Los Alamos National Laboratory

    2017-02-03

    A review of available very high-resolution commercial satellite imagery (bracketing the time of North Korea’s most recent underground nuclear test on 9 September 2016 at the Punggye-ri Underground Nuclear Test Site) has led to the detection and identification of several minor surface disturbances on the southern flank of Mt. Mantap. These surface disturbances occur in the form of small landslides, either alone or together with small zones of disturbed bare rock that appear to have been vertically lofted (“spalled”) as a result of the most recent underground explosion. Typically, spall can be uniquely attributed to underground nuclear testing and is not a result of natural processes. However, given the time gap of up to three months between images (pre- and post-event), which was coincident with a period of heavy typhoon flooding in the area1, it is not possible to determine whether the small landslides were exclusively explosion induced, the consequence of heavy rainfall erosion, or some combination of the two.

  17. Study on the pulmonary mean transit time and the pulmonary blood volume by RI-cardiogram

    Energy Technology Data Exchange (ETDEWEB)

    Ushio, N.

    1987-03-01

    The pulmonary mean transit time and the pulmonary blood volume in cases of cardio-pulmonary disease were measured using Giuntini's method which is considered the most appropriate among radiocardiographic methods. The errors in this method were confirmed to be almost negligible. The results obtained were as follows: 1) The pulmonary mean transit time was related to the systemic mean transit time and markedly prolonged in left heart failure. On the other hand, it was markedly shortened in some cases of chronic pulmonary disease, particularly pulmonary emphysema. 2) The pulmonary blood volume tended to increase in left heart disorders and mitral valve disease and tended to decrease in the chronic pulmonary disease. The decrease was conspicuous particularly in some cases of pulmonary emphysema. 3) A structural change of the pulmonary vascular system in the chronic pulmonary disease appeared to bring about shortening of the pulmonary mean transit time and a decrease in the pulmonary blood volume. The pathophysiology of cardio-pulmonary disease can be more clarified by the RI-cardiogram used in this study, in which the pulmonary mean transit time and the pulmonary blood volume are used as the indicator.

  18. Construction of high resolution beam line for SHARAQ spectrometer at RIKEN RI Beam Factory

    Science.gov (United States)

    Yanagisawa, Yoshiyuki; Kubo, Toshiyuki; Kusaka, Kensuke; Ohtake, Masao; Yoshida, Koichi; Ohnishi, Tetsuya; Sasamoto, Yoshiko; Saito, Akito; Uesaka, Tomohiro; Shimoura, Susumu; Kawabata, Takahiro; Noji, Shumpei; Sakai, Hideyuki

    2009-10-01

    A high resolution beam line [1] has been constructed for the SHARAQ spectrometer [2] at RIKEN RI Beam Factory (RIBF), in order to achieve dispersion matching that allows high resolution measurement at the focal plane of the spectrometer. This beam line is formed by the existing BigRIPS separator [3] at RIBF and a newly constructed beam line that diverges from BigRIPS and leads to the target position of SHARAQ. The ion optics is so designed that it can be operated in the dispersion matching mode. The new part of the beam line consists of two 30-degree bend dipoles, three quadrupole singlets and three superconducting quadrupole triplets. Recently the beam line has been successfully commissioned together with the SHARAQ spectrometer. Overview of the beam line will be reported. [1] T. Kawabata et al.: Nucl. Instr. and Meth. B 266 (2008) 4201. [2] T. Uesaka et al.: Nucl. Instr. and Meth. B 266 (2008) 4218. [3] T. Kubo: Nucl. Instr. and Meth. B 204 (2003) 97.

  19. Rod al unor căutări ştiinţifice de valoare

    Directory of Open Access Journals (Sweden)

    Sergiu VLĂDICĂ

    2017-06-01

    Full Text Available În fiecare an, Secția activitate editorială a Academiei de Administrare Publică editează în volum aparte materialele conferinţelor ştiinţifico-practice cu participare internațională „Teoria şi practica administrării publice”. Culegerea din acest an conține 120 de materiale, semnate de cercetători ai Academiei, altor instituții de învățământ superior din țară şi din instituții similare din străinătate, ai autorităților administrației publice centrale şi locale. În articol sunt evidențiate cele mai relevante cercetări ştiințifice prezentate în şedința plenară a Conferinței, precum şi în cadrul celor şase ateliere de lucru.

  20. INTERVIUL RADIOFONIC CU TEMATICĂ POLITICĂ: ABORDĂRI TEORETICE ŞI PRACTICI OPERAȚIONALE

    Directory of Open Access Journals (Sweden)

    Mariana MARCU

    2017-07-01

    Full Text Available Noile realităţi politice conturate după declararea independenţei Republicii Moldova au generat schimbări importante şi în profilul genurilor radiofonice. Abordarea teoretică a interviului radiofonic cu tematică politică, dar şi exerciţiul practic creează o nouă viziune asupra interviului atât sub aspectul relaţiei dintre participanţii la dialog, cât şi sub aspectul naturii mesajului transmis.RADIO INTERVIEW ON POLITICAL ISSUES: THEORETICAL APPROACH AND OPERATIONAL PRACTICIESThe new political outlined realities after Moldova's independence declaration led to important changes in the profile of radio genres. The theoretical approach of political-themed radio interview, as well as the practical exercise creates a new vision of the interview both in terms of the relationship between dialogue participants and in terms of the type of the message sent.

  1. SERS nanosensors that report pH of endocytic compartments during FcεRI transit

    Science.gov (United States)

    Nowak-Lovato, K.L.; Wilson, Bridget S.; Rector, K.D.

    2011-01-01

    Recently, the development of an IgE receptor (FcεRI)-targeted, pH sensitive, surface-enhanced Raman spectroscopy (SERS) nanosensor has been demonstrated [1]. The targeted nanosensor enables spatial and temporal pH measurements as internalized receptors progress through endosomal compartments in live cells. Trafficking of receptor-bound nanosensors was compared at physiological temperature (37°C) versus room temperature (25°C). As expected, we observed markedly slower progression of receptors through low pH endocytic compartments at the lower temperature. We also demonstrate the utility of the nanosensors to measure directly changes in the pH of intracellular compartments after treatment with bafilomycin or amiloride. We report an increase in endosome compartment pH after treatment with bafilomycin, an H+ ATPase pump inhibitor. Decreased endosomal luminal pH was measured in cells treated with amiloride, an inhibitor of Na+/H+ exchange. The decrease in amiloride-treated cells was transient, followed by a recovery period of approximately 15–20 minutes to restore endosomal pH. These experiments demonstrate the novel application of Raman spectroscopy to monitor local pH environment in live cells with the use of targeted SERS nanosensors. PMID:20842349

  2. Development of RI protein chip system for measurement of ADMA as risk factor of liver disease, cardiovascular disease and diabetes

    Energy Technology Data Exchange (ETDEWEB)

    Park, Gil Hong; An, Sin Ae; Choi, Hyun Mi; Cheong, Kyung Ah; Chang, Yeon Soo [Korea University, Seoul (Korea, Republic of)

    2010-05-15

    ADMA (asymmetric dimethylarginine) is an endogenous competitive NOS (nitric oxide synthase) inhibitor. Elevation of ADMA level in body fluid is related to various diseases including diabetes mellitus, atherosclerosis, hypercholesterolemia, chronic heart failure, and hypertension. Our goal was to elucidate the role for ADMA and protein arginine methylation in the pathogenesis of diabetes and develop RI protein chip system for easy determination of ADMA levels in blood or tissues. As a result, ADMA regulated by protein arginine methylation, DDAH1, and NOS was demonstrated to play some role in the pathogenesis of diabetes mellitus, and arginine methylation of some proteins indicated their possible involvement in the change in ADMA levels. The concept of the RI protein chip system was devised such that firstly, ADMA was acylated by radio-labelled succinic acid, and followed by binding of the complex to anti-acyl ADMA-specific antibody coated on chip. Acylation condition of ADMA with radio-labelled succinic acid was established

  3. Validated HPLC-RI Method for the Determination of Lactulose and its Process Related Impurities in Syrup.

    Science.gov (United States)

    Nelofar, A; Laghari, A H; Yasmin, A

    2010-03-01

    A simple, swift with good sensitivity and reproducibility, HPLC-RI method has been developed for the quantification of lactulose and related compounds (fructose, galactose, epilactose and lactose) in oral suspension formulation. The analysis was carried out by using mobile phase (water and acetonitrile 75:25) at the flow rate of 1.0 ml/min. on isocratic HPLC-RI system. After manipulating mobile phase composition and mobile phase flow rate a good separation of five components was achieved within 15 minutes of run time. This study is beneficial to determine the active ingredient as well as related compounds simultaneously, without using buffer in mobile phase which causes bad resolution and has limitation to analyze on other hyphenated techniques such as LC-MS.

  4. Cross-linking of bromodeoxyuridine-substituted oligonucleotides to the EcoRI and EcoRV restriction endonucleases.

    Science.gov (United States)

    Wolfes, H; Fliess, A; Winkler, F; Pingoud, A

    1986-09-01

    We have synthesized several self-complementary oligodeoxynucleotides which contain bromodeoxyuridine in various positions within and outside of the recognition sequence for the EcoRI and EcoRV restriction endonucleases. These oligodeoxynucleotides are cleaved in the presence of Mg2+ by their respective enzyme. Upon irradiation by long-wavelength ultraviolet light and in the absence of Mg2+ they are cross-linked in low yield to their enzymes, forming 1:1 and 1:2 (oligodeoxynucleotide:enzyme subunit) adducts. Cross-linking occurs with both specific and non-specific complexes. With EcoRI the site of cross-linking was determined to be at or close to Met-137, i.e. in a region of the molecule implicated by other studies from our laboratory [Scholtissek et al. (1986) J. Biol. Chem. 261, 2228-2234] in the binding and cleavage of the substrate.

  5. Intrinsic vulnerability assessment of the aquifer in the Rižana spring chatcment by method SINTACS

    Directory of Open Access Journals (Sweden)

    2002-12-01

    Full Text Available In this paper is presented intrinsic vulnerability assessment of the aquifer in the Rižana spring chatcment by the method SINTACS. It is parametric method that takes into consideration seven parameters (depth to ground water, effective infiltration action, unsaturatedzone attenuation capacity, soil/overburden attenuation capacity, hydrogeological characteristics of the aquifer, hydraulic conductivity range of aquifer, hydrologic role of the topographic slope. Parameters are presented in grid information layers that wereelaborated on the basis of interpretation and GIS processing of geological, hydrogeological,speleological, topographical, meteorological and pedological data. According to the parametersimportance for vulnerability assessment, a multiplier (importance weight was assigned to each parameter. Final map of vulnerability is a result of overlaying (summing of weighted information layers (parameters and shows the catchment area of the Rižanaspring subdivided into six vulnerability classes.

  6. Carboplatin-induced severe hypersensitivity reaction: Role of IgE-dependent basophil activation and FcεRI

    OpenAIRE

    Iwamoto, Takuya; Hirai, Hiroyuki; Yamaguchi, Nozomi; Kobayashi, Natsuki; Sugimoto, Hiroko; Tabata, Tsutomu; Okuda, Masahiro

    2014-01-01

    Basophil activation was observed in patients with a history of carboplatin-induced severe hypersensitivity reaction (HR). However, the precise mechanism by which carboplatin induces basophil activation and the associated surrogate markers remains to be elucidated. To investigate whether IgE-dependent mechanisms, including the overexpression of FcεRI, participate in carboplatin-induced basophil activation, 13 ovarian cancer patients were enrolled: 5 with a history of carboplatin-induced severe...

  7. Tallinn-London-Newcastle, vahepeatusega Äksis / Jüri Kermik ; interv. Tõnu Kaalep ja Harry Liivrand

    Index Scriptorium Estoniae

    Kermik, Jüri, 1957-

    2002-01-01

    Disainer räägib oma tööst õppejõuna ja mööblidisainerina Londonis ning äsjailmunud monograafiast "A. M. Luther (1877-1940). Materjalist võrsunud vormiuuendus". Käsitletakse ka inglise ja eesti mööblidisaini momendiolukorda ning viimase aja tööd, Äksi tooli. Jüri Kermiku (s. 1957) biograafilised lühiandmed

  8. Dental caries prevalence as a product of agriculture and subsistence pattern at the Yean-ri site, South Korea.

    Science.gov (United States)

    Fujita, H; Hashimoto, H; Shoda, S; Suzuki, T

    2011-01-01

    Yean-ri human skeletal remains from South Korea have been dated to the fourth to seventh century AD. They have morphological similarities to immigrants of the Yayoi period excavated in northern Kyushu and Yamaguchi prefecture in Japan. The overall dental caries prevalence was 8.1% in the Yean-ri skeletal remains, indicating a much lower prevalence than that of most Yayoi immigrant skeletal remains from Japan, although similar to that of the Kofun people (8.3%) in Japan. There was no significant difference in the dental caries prevalence between the males and females of the same age group, but there were differences in the prevalence by age. The late middle age and elderly males and females had significantly higher dental caries prevalence than the early middle age males and females, indicating increased prevalence with age. Root caries prevalence tended to increase in old age. The percentage of root caries increased, accounting for 80% of all caries in Yean-ri human skeletal remains. Agriculture is believed to have arisen approximately 3,000 years ago in Korea. Therefore, agriculture was practiced during this period, but since the Yean-ri tumuli are from coastal areas, their diet may have retained a significant marine component. Additionally, caries prevalence was not very high in Nukdo human remains (ca. 2100-2000 BC) in Korea. We speculate that they maintained subsistence activities suitable for their environment despite their knowledge of agriculture. This hypothesis is supported by differences in the caries prevalence between excavation sites of the Yayoi and Kofun periods in Japan. Copyright © 2011 S. Karger AG, Basel.

  9. Contribution of IL-1RI Signaling to Protection against Cryptococcus neoformans 52D in a Mouse Model of Infection

    Directory of Open Access Journals (Sweden)

    Mitra Shourian

    2018-01-01

    Full Text Available Interleukin-1 alpha (IL-1α and interleukin-1 beta (IL-1β are pro-inflammatory cytokines that are induced after Cryptococcus neoformans infection and activate the interleukin-1 receptor type I (IL-1RI. To establish the role of IL-1RI signaling in protection against cryptococcal infection, we analyzed wild-type (WT and IL-1RI-deficient (IL-1RI−/− mice on the BALB/c background. IL-1RI−/− mice had significantly reduced survival compared to WT mice after intratracheal challenge with C. neoformans 52D. Microbiological analysis showed a significant increase in the lung and brain fungal burden of IL-1RI−/− compared to WT mice beginning at weeks 1 and 4 postinfection, respectively. Histopathology showed that IL-1RI−/− mice exhibit greater airway epithelial mucus secretion and prominent eosinophilic crystals that were absent in WT mice. Susceptibility of IL-1RI−/− mice was associated with significant induction of a Th2-biased immune response characterized by pulmonary eosinophilia, M2 macrophage polarization, and recruitment of CD4+ IL-13+ T cells. Expression of pro-inflammatory [IL-1α, IL-1β, TNFα, and monocyte chemoattractant protein 1 (MCP-1], Th1-associated (IFNγ, and Th17-associated (IL-17A cytokines was significantly reduced in IL-1RI−/− lungs compared to WT. WT mice also had higher expression of KC/CXCL1 and sustained neutrophil recruitment to the lung; however, antibody-mediated depletion of these cells showed that they were dispensable for lung fungal clearance. In conclusion, our data indicate that IL-1RI signaling is required to activate a complex series of innate and adaptive immune responses that collectively enhance host defense and survival after C. neoformans 52D infection in BALB/c mice.

  10. Lääs ja süntetismi väljakutsed / Jüri Talvet

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    2002-01-01

    Kokkuvõte "The West and the challenge of synthetism", lk. 1089-1090. Kriitiliselt Lääne kultuuriuuringute diskursustest: eksistentsialism, strukturalism, psühhoanalüüs, poststrukturalism. Essee aluseks on hispaaniakeelne plenaarettekanne rahvusvahelisel kongressil Valencias (dets. 2001). Vastukaja: Arujärv, Evi. Õhumüügist ja turvateenusest // Sirp (2002) 14. juuni, lk. 3. Essee on ilmunud ka kogumikus: Talvet, Jüri. Tõrjumatu äär. Tartu : Ilmamaa, 2005, lk. 9-30

  11. Subsurface cavity detection in a karst environment using electrical resistivity (er: a case study from yongweol-ri, South Korea

    Directory of Open Access Journals (Sweden)

    Farooq Muhammad

    2012-10-01

    Full Text Available

    ABSTRACT

    Karst voids were encountered during road construction in Yongweol-ri, South Korea. Attempts to determine the extent of the karst voids through drilling was expensive, time-consuming and too dangerous. An electrical resistivity survey was thus carried out to investigate current subsurface geology beneath the proposed road network. This investigation was aimed at imaging karstic voids and detecting areas prone to ground subsidence through the collapse of cavities beneath a road segment overlying such features. A numerical modelling study preceded the field survey to determine whether the electrical resistivity method could identify such features. The field data set consisted of eleven electric profiles acquired using dipoledipole array; electrical resistivity profiles (100 m and 300 m length were measured using a dipole-dipole electrode configuration and electrode spacing was kept at 5 m to ensure good coverage of the study area. The resistivity data was inverted using 2D and 3D algorithms based on the least squares smoothness constraint technique. The inverted resistivity images provide a clear view of weathered soils, the distribution of weak areas or karst voids and bed rock. Several low resistivity areas were identified and the subsequent drilling of such anomalous areas led to the discovery of several weak zones or clayfilled underground cavities; the drilling results had excellent correlation with the resistivity images. The electrical resistivity imaging result proved precise and extremely efficient in delineating the karstic void investigation and should be taken into account when choosing an investigation technique to be used at complex geological sites. A remedial action plan involving consolidation grouting work has been suggested prior to road construction.


    Proceeding of the workshop on gamma-ray spectroscopy utilizing heavy-ion, photon and RI beams

    Energy Technology Data Exchange (ETDEWEB)

    Oshima, Masumi; Sugita, Michiaki; Hayakawa, Takehito [eds.

    1998-03-01

    Three time since 1992, we have held the symposia entitled `Joint Spectroscopy Experiments Utilizing JAERI Tandem-Booster Accelerator` at the Tokai Research Establishment. In the symposia, we have mainly discussed the plans of experiments to be done in this joint program. The joint program started in 1994. Several experiments have been made since and some new results have already come up. This symposium `Gamma-ray Spectroscopy utilizing heavy-ion, Photon and RI beams` was held at Tokai Research Establishment of JAERI. Because this symposium is the first occasion after the program started, the first purpose of the symposium is to present and discuss the experimental results so far obtained using the JAERI Tandem-Booster. The second purpose of the symposium is to discuss new possibilities of gamma-ray spectroscopy using new resources such as RI-beam and Photon-beam. The participants from RIKEN, Tohoku University and JAERI Neutron Science Research Center presented the future plans of experiments with RI-beam at each facility. Compared with these nuclear beams, photon beam provides a completely new tool for the {gamma}-ray spectroscopy, which is achieved by inverse Compton scattering between high-energy electron and laser beams. The 23 of the presented papers are indexed individually. (J.P.N.)

  12. Analytical Characterization of the Hydrolysis of Barley Malt Macromolecules During Enzymatic Degradation Over Time Using AF4/MALS/RI.

    Science.gov (United States)

    Rübsam, Heinrich; Becker, Thomas; Gastl, Martina

    2017-06-01

    The changes on the molecular weight distribution (MWD) and particle size distribution (PSD) during hydrolysis of barley malt in isothermal mashing procedures were determined using asymmetrical flow field flow fractionation coupled to multiangle laser light scattering and refractive index (AF4/MALS/RI). Mash/trials were focused on amylolytic starch degradation. Therefore, temperatures (65, 70, and 75 °C) were selected according to α- and β-amylases range of activity. Samples were produced by triplicate, tracking amylolytic processes over time periods from 10 to 90 min in each mash/trial. AF4/MALS/RI analysis demonstrated significant differences on the values of the MWD and PSD according to the temperature/time profile used. At mashing times over 30 min at a temperature of 65 °C, when α- and β-amylase are both active, the decrease over time of the MWD and PSD was significantly higher (P RI would be a powerful tool for breweries to adapt their technological processes to obtain beers with particular sensorial attributes. © 2017 Institute of Food Technologists®.

  13. Quantitative and clinical evaluation of whole CSF-axis RI image. Significance of spinal stasis in particular

    Energy Technology Data Exchange (ETDEWEB)

    Tomono, Y.; Nose, T.; Maki, Y.

    1987-04-01

    Whole CSF-axis RI scintigraphy was evaluated in 122 adult patients intending to determine intracranial CSF flow and also the dynamics of whole CSF axis, particularly that of spinal CSF flow. The change of radioactivity in several compartments was studied quantitatively with a data processor in 18 cases with dilated ventricles. More practically, clinical features and the findings of the films were comparatively studied in all the cases. The results were as follows: (1) the findings were classified into two types, i.e. a type with early RI movement to the intracranial CSF space and another with stagnation of radioactivity in spinal space till late stage, even 48 hours after RI injection (spinal stasis). (2) Although majority of the cases with spinal stasis did not show ventricular stasis, a shunt operation was not effective even when ventricular stasis was observed. (3) Spinal stasis tended to increase with aging, and was observed more frequently in cases with possible severe cerebral damage, as severe cerebrovascular disease and severe deterioration of mental activity. (4) The clearance of radioactivity of whole CSF-axis was remarkably delayed. It is considered that the spinal CSF flow is generated by intracranial CSF pulsation and that spinal stasis shows the condition of lowered CSF flow by pulsation due to cerebral parenchymal damages.

  14. Manager- bändikarjääri disainija ja kokkusõlmija / Paul Cheeetham, Tapio Korjus, Petri H. Lunden ...[jt.

    Index Scriptorium Estoniae

    Cheetham, Paul

    2010-01-01

    Muusikamanageride Paul Cheethami, Tapio Korjuse, Petri H. Lundeni, Kari Pössi ja Rasmus Stolbergi arvamusi oma tööst ja nõuannetest eesti ansamblitele, kes tahavad oma karjääri teha rahvusvahelisel areenil

  15. Miks on tühjad tähistajad poliitikas olulised? / Ernesto Laclau ; tõlk. Jüri Lipping

    Index Scriptorium Estoniae

    Laclau, Ernesto

    2002-01-01

    Filosoofiline arutelu "tühjade tähistajate" ühiskondlikust tootmisest. Hegemoonia. Hegemoonia ja demokraatia. Artikli lõpus Jüri Lippingu ülevaade Ernesto Laclau ja Chantal Mouffe teosest "Hegemony and Socialist Strategy"

  16. LncRNA lnc-RI regulates homologous recombination repair of DNA double-strand breaks by stabilizing RAD51 mRNA as a competitive endogenous RNA.

    Science.gov (United States)

    Shen, Liping; Wang, Qi; Liu, Ruixue; Chen, Zhongmin; Zhang, Xueqing; Zhou, Pingkun; Wang, Zhidong

    2017-12-04

    DNA double-strand break (DSB) repair is critical for the maintenance of genome stability. The current models of the mechanism of DSB repair are based on studies of DNA repair proteins. Long non-coding RNAs (lncRNAs) have recently emerged as new regulatory molecules, with diverse functions in biological processes. In the present study, we found that expression of the ionizing radiation-inducible lncRNA, lnc-RI, was correlate negatively with micronucleus frequencies in human peripheral blood lymphocytes. Knockdown of lnc-RI significantly increased spontaneous DSBs levels, which was confirmed to be associated with the decreased efficiency of homologous recombination (HR) repair of DSBs. The expression of RAD51, a key recombinase in the HR pathway, decreased sharply in lnc-RI-depressed cells. In a further investigation, we demonstrated that miR-193a-3p could bind with both lnc-RI and RAD51 mRNA and depressed the expression of lnc-RI and RAD51 mRNA. Lnc-RI acted as a competitive endogenous RNA (ceRNA) to stabilize RAD51 mRNA via competitive binding with miR-193a-3p and release of its inhibition of RAD51 expression. To our knowledge, this is the first study to demonstrate the role of lnc-RI in regulating HR repair of DSBs. The feedback loop established in the current study suggests that lnc-RI is critical for the maintenance of genomic stability. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

  17. Jaanus Rahumägi : Jüri Pihl ei räägi tõtt / Jaanus Rahumägi ; interv. Raimo Poom

    Index Scriptorium Estoniae

    Rahumägi, Jaanus, 1963-

    2008-01-01

    Riigikogu erikomisjoni juhi Jaanus Rahumägi hinnangul on sõjaväeluure teemas palju otsest valet ning siseminister Jüri Pihli väited sellel teemal ei vasta tõele. Rahumägi kinnitab, et Eestisse ei looda kolmandat julgeolekuasutust ning selgitab, et sõjaväeluuret käsitletakse teabeameti tegevusvaldkonnana, mitte eraldiseisva luureüksusena kaitseväe koosseisus. Kommenteerib Jüri Pihl

  18. Learning Networks, Networked Learning

    NARCIS (Netherlands)

    Sloep, Peter; Berlanga, Adriana

    2010-01-01

    Sloep, P. B., & Berlanga, A. J. (2011). Learning Networks, Networked Learning [Redes de Aprendizaje, Aprendizaje en Red]. Comunicar, XIX(37), 55-63. Retrieved from http://dx.doi.org/10.3916/C37-2011-02-05

  19. Hepatotoxicity after liver irradiation in children and adolescents. Results from the RiSK

    Energy Technology Data Exchange (ETDEWEB)

    Roesler, Pascal; Christiansen, Hans [Medical School Hannover, Department of Radiotherapy and Special Oncology, Hannover (Germany); Kortmann, Rolf-Dieter [University of Leipzig, Department of Radiotherapy, Leipzig (Germany); Martini, Carmen [University Hospital of Freiburg, Department of Radiotherapy, Freiburg im Breisgau (Germany); Matuschek, Christiane [Heinrich-Heine University of Duesseldorf, Department of Radiotherapy, Medical Faculty, Duesseldorf (Germany); Meyer, Frank [Hospital Augsburg, Department of Radiotherapy, Augsburg (Germany); Ruebe, Christian [University Hospital of Homburg/Saar, Department of Radiotherapy, Homburg/Saar (Germany); Langer, Thorsten [University Hospital of Schleswig-Holstein, Department of Pediatrics, Pediatric Oncology, Campus Luebeck (Germany); Koch, Raphael [University of Muenster, Institute of Biostatistics and Clinical Research, Muenster (Germany); Eich, Hans Theodor; Willich, Normann [University Hospital of Muenster, Department of Radiotherapy, Muenster (Germany); Steinmann, Diana [Medical School Hannover, Department of Radiotherapy and Special Oncology, Hannover (Germany); University Hospital of Muenster, Department of Radiotherapy, Muenster (Germany)

    2015-05-01

    The aim of this study was to evaluate acute and late radiotherapy-associated hepatotoxicity in consideration of dose-volume effects and liver function in childhood and adolescence. Since 2001, irradiated children and adolescents in Germany have been prospectively documented in the ''Register of Treatment-Associated Late Effects After Radiotherapy of Malignant Diseases in Childhood and Adolescence (RiSK)'' using standardized forms. Toxicity was graded according to the Radiation Therapy Oncology Group (RTOG) criteria. Until April 2012, 1,392 children and adolescents from 62 radiotherapy centers were recruited. In all, 216 patients underwent irradiation of the liver (median age 9 years, range 1-18 years, 70 patients with total-body irradiation, TBI). For 75 % of patients without TBI, information on acute toxicity of the liver was available: 24 patients had acute toxicity of grade 1-4 (grade 1, 2, and 4, in 20, 3, and 1 patient, respectively), including five patients receiving simultaneous hepatotoxic chemotherapy. Information on late toxicity was documented in 465 forms from 216 patients, with a median follow-up of 2 years. A maximum grade of toxicity of ≥ 0 occurred in 18 patients over time (with grade 1, 2, and 3 toxicity occurring in 15, 2, and 1 patient, respectively), including three patients (17 %) with TBI. One of them received simultaneous hepatotoxic chemotherapy. In multivariable analysis, volume-dose correlations showed no statistically noticeable effect on acute or chronic toxicity. Only low hepatotoxicity developed in children after irradiation of various abdominal and thoracic tumors. Due to the low radiation doses to the liver (median liver dose = 5 Gy) and the low toxicities that were consecutively observed, dose-volume curves for liver toxicity could not be established. These findings reflect the cautious attitude of radiation oncologists in terms of attributable liver doses in the treatment of the investigated tumor entities. It

  1. Agrobacterium rhizogenes pRi8196 T-DNA: mapping and DNA sequence of functions involved in mannopine synthesis and hairy root differentiation.

    Science.gov (United States)

    Hansen, G; Larribe, M; Vaubert, D; Tempé, J; Biermann, B J; Montoya, A L; Chilton, M D; Brevet, J

    1991-01-01

    This paper presents the map and DNA sequence analysis of pRi8196 transferred DNA (T-DNA) genes encoding root-inducing and mannopine synthesis functions. A canonical 24-base-pair border repeat as well as two "pseudoborders" are present at the functional right T-DNA border. To the left of this border are homologs of the mas1' and mas2' genes of TR pRiA4. Next to these are five open reading frames (ORFs) homologous to ORFs 10-14 of TL of pRiA4. ORFs 10-12 (rolA, rolB, and rolC) are less related to their pRiA4 homologs than are the other large ORFs analyzed here. In contrast to T-DNA genes of pRiA4, pRi8196 T-DNA ORFs 11 and 12 (rolB and rolC) are sufficient to induce hairy roots on carrot disks. Images PMID:1909028

  2. In vivo effector functions of high-affinity mouse IgG receptor FcγRI in disease and therapy models.

    Science.gov (United States)

    Gillis, Caitlin M; Zenatti, Priscila P; Mancardi, David A; Beutier, Héloïse; Fiette, Laurence; Macdonald, Lynn E; Murphy, Andrew J; Celli, Susanna; Bousso, Philippe; Jönsson, Friederike; Bruhns, Pierre

    2017-06-01

    Two activating mouse IgG receptors (FcγRs) have the ability to bind monomeric IgG, the high-affinity mouse FcγRI and FcγRIV. Despite high circulating levels of IgG, reports using FcγRI(-/-) or FcγRIV(-/-) mice or FcγRIV-blocking antibodies implicate these receptors in IgG-induced disease severity or therapeutic Ab efficacy. From these studies, however, one cannot conclude on the effector capabilities of a given receptor, because different activating FcγRs possess redundant properties in vivo, and cooperation between FcγRs may occur, or priming phenomena. To help resolve these uncertainties, we used mice expressing only FcγRI to determine its intrinsic properties in vivo. FcγRI(only) mice were sensitive to IgG-induced autoimmune thrombocytopenia and anti-CD20 and anti-tumour immunotherapy, but resistant to IgG-induced autoimmune arthritis, anaphylaxis and airway inflammation. Our results show that the in vivo roles of FcγRI are more restricted than initially reported using FcγRI(-/-) mice, but confirm effector capabilities for this high-affinity IgG receptor in vivo. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Síndrome pulmón-riñón Pulmonary-renal syndrome

    Directory of Open Access Journals (Sweden)

    Jorge A. Risso

    2009-12-01

    Full Text Available El síndrome pulmón-riñón se define como una combinación de hemorragia alveolar difusa y glomerulonefritis. La coexistencia de estas dos afecciones clínicas se produce por enfermedades con distintos mecanismos patogénicos. Las vasculitis sistémicas primarias y el síndrome de Goodpasture son las etiologías más frecuentes. El lupus eritematoso sistémico, otras colagenopatías, las vasculitis con anticuerpos anticitoplasma de los neutrófilos negativos y las secundarias a drogas son causas mucho menos comunes. El diagnóstico temprano basado en criterios clínicos, radiológicos, de laboratorio e histológicos, permite iniciar el tratamiento disminuyendo su elevada morbi-mortalidad. La terapéutica se basa en altas dosis de corticoides, inmunosupresores, inhibidores del factor de necrosis tumoral y plasmaféresis.The pulmonary-renal syndrome is defined as a combination of diffuse alveolar hemorrhage and glomerulonephritis. The coexistence of these two clinical conditions is due to diseases with different pathogenic mechanisms. Primary systemic vasculitis and Goodpasture syndrome are the most frequent etiologies. Systemic lupus erythematosus, connective tissue diseases, negative anti neutrophil cytoplasmic antibody vasculitis and those secondary to drugs are far less common causes. An early diagnosis based on clinical, radiologic, laboratory and histologic criteria enables early treatment, thus diminishing its high morbility-mortality rate. Therapy is based on high doses of corticosteroids, immunosuppressants, tumor necrosis factor inhibitors and plasmapheresis.

  4. Genetic variability to diet-induced hippocampal dysfunction in BXD recombinant inbred (RI) mouse strains.

    Science.gov (United States)

    Xue, Yueqiang; Li, JingJing; Yan, Lei; Lu, Lu; Liao, Francesca-Fang

    2015-10-01

    Evidence has emerged suggesting that diet-induced obesity can have a negative effect on cognitive function. Here, we exploited a mouse genetic reference population to look for the linkage between these two processes on a genome-wide scale. The focus of this report is to determine whether the various BXD RI strains exhibited different behavioral performance and hippocampal function under high fat dietary (HFD) condition. We quantified genetic variation in body weight gain and consequent influences on behavioral tests in a cohort of 14 BXD strains of mice (8-12 mice/strain, n = 153), for which we have matched data on gene expression and neuroanatomical changes in the hippocampus. It showed that BXD66 was the most susceptible, whereas BXD77 was the least susceptible strain to dietary influences. The performance of spatial reference memory tasks was strongly correlated with body weight gain (P < 0.05). The obesity-prone strains displayed more pronounced spatial memory defects compared to the obesity-resistant strains. These abnormalities were associated with neuroinflammation, synaptic dysfunction, and neuronal loss in the hippocampus. The biological relevance of DSCAM gene polymorphism was assessed using the trait correlation analysis tool in Genenetwork. Furthermore, a significant strain-dependent gene expression difference of DSCAM was detected in the hippocampus of obese BXD strains by real-time quantitative PCR. In conclusion, a variety of across-strain hippocampal alterations and genetic predispositions to diet-induced obesity were found in a set of BXD strains. The obesity-prone and obesity-resistant lines we have identified should be highly useful to study the molecular genetics of diet-induced cognitive decline. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. DUA PULUH LIMA TAHUN KERJA SAMA DEPKES RI DENGAN NAMRU-2

    Directory of Open Access Journals (Sweden)

    Suriadi Gunawan

    2012-09-01

    Full Text Available Buletin nomor ini diterbitkan untuk memperingati 25 tahun kerja sama antara Departemen Kesehatan RI dan U.S. Naval Medical Research Unit No. 2 (NAMRU-2. Kerja sama ini telah menghasilkan sumbangan yang sangat berharga untuk peningkatan kesehatan baik di Indonesia maupun di dunia, khususnya di negara sedang berkembang. Hasil evaluasi vaksin typhoid dan cara pengobatan malaria serta dehidrasi berat akibat diare adalah beberapa contoh dari kerja sama ini yang sangat bermanfaat untuk mencegah penyakit dan kematian. Hasil kerja sama dalam 20 tahun pertama telah diseminarkan dalam tahun 1990 dan dipublikasikan dalam suatu nomor khusus buletin ini. Dengan staf yang terdiri dari 20 orang asing, dan 140 orang Indonesia, NAMRU-2 telah melaksanakan berbagai penelitian di berbagai daerah bersama peneliti Badan Litbangkes, Universitas, Angkatan Bersenjata serta dinas kesehatan setempat. Lebih dari 400 publikasi ilmiah telah dihasilkan oleh kerja sama ini. Dalam lima tahun terakhir penelitian berbagai aspek malaria di Irian Jaya antara lain telah menghasilkan peta resistensi obat malaria dan penemuan manfaat primakuin sebagai obat profilaksis yang aman dan relatif murah. Uji coba fase III vaksin tifoid oral Ty21a telah dilaksanakan di Sumatra Selatan, sedangkan suatu vaksin kolera oral, CVD 103 HgR, sedang diuji coba fase III di Jakarta. Penelitian genotype HIV di Indonesia yang telah dilaksanakan bersama Universitas Indonesia dan Dinas Kesehatan ABRI telah membantu memperjelas epidemi HIV/AIDS di Indonesia. Penelitian lapangan mengenai hepatitis E di Kalimantan dan Japanese Encephalitis di Bali telah memperjelas penularan dan risiko penyakit tersebut. Badan Litbangkes dan NAMRU akan melanjutkan kerjasama penelitian dan pelatihan di bidang penyakit menular dalam masa lima tahun yang akan datang. Beberapa bidang yang akan mendapat perhatian ialah surveilans berbagai penyakit infeksi yang baru dan timbul kembali (new and reemerging infections, uji coba berbagai

  6. Riñón fetal hiperecogénico Hyperechogenic fetal kidney

    Directory of Open Access Journals (Sweden)

    Sandalio Durán Álvarez

    2011-12-01

    Full Text Available El hallazgo de riñones fetales hiperecogénicos es un problema de gran preocupación médica y de ansiedad familiar, porque casi siempre traduce una enfermedad renal importante. Cuando la hiperecogenicidad se acompaña de oligohidramnios, la mayoría de las veces estamos enfrentando una enfermedad poliquística; cuando no existe oligohidramnios, el diagnóstico probable es difícil. El objetivo de este reporte es la presentación de un niño con enfermedad poliquística autosómico recesiva. En los exámenes realizados a la madre, durante el embarazo, se encontró hiperecogenia renal y oligohidramnios. Se describe la evolución clínica, ultrasonográfica y gammagráfica de su enfermedad. Se revisa brevemente la literatura con relación al tema.The finding of hyperechogenic fetal kidneys is a problem of a great medical concern and of family anxiety, because of almost always it expresses an important renal disease. When hyper-echogenicity is accompanied by oligohydramnios, usually we are facing a polycystic disease; where there are not oligohydramnios the potential diagnosis is difficult. The objective of present paper is the presentation of a child presenting with recessive autosomal polycystic disease. En examinations performed in the mother during pregnancy, it was found a renal hyperechogeny and oligohydramnios. The clinical evolution, ultrasonography and scintigraphy of its disease is described and a brief review of literature in relation to thus subject is reviewed.

  7. Measuring and monitoring in the South African Kha Ri Gude mass literacy campaign

    Science.gov (United States)

    McKay, Veronica

    2015-06-01

    After many previous failed attempts to reach illiterate adults, the award-winning South African Kha Ri Gude mass literacy campaign, launched in 2008, undertook to ensure that learners seized the opportunity to learn - for many adults, this was a "last chance". Written from an insider perspective by the campaign's founding Chief Executive Officer, this article outlines the features which contributed to its success despite the many challenges it initially faced. The author outlines the social and legislative backdrop, notably the South African National Qualifications Framework (NQF) providing the scaffold for the continuum of adult learning and the assessment of learning outcomes, and examines the various components which influenced the design of the campaign. She focuses, in particular, on the learning outcomes measurement model tailored to the campaign's specific context, namely a structured and standardised learner assessment portfolio (LAP). Designed as a tool to be administered universally for both formative and diagnostic purposes, the portfolio enables continuous assessment, forming an integral part of the process of learning and teaching. After many initial challenges encountered in introducing this mode of learner assessment, it was eventually institutionalised and found to be a non-threatening way of assessing learning outcomes while also functioning as a tool for monitoring and ensuring accountability in the campaign. This article gives an account of the development considerations and explains the role of the assessment process within the broader context of the campaign. It also refers to ways in which the mass-based assessments were administered under difficult campaign conditions with a view to assessing for learning.

  8. Molecular and morphological diversity of Narragansett Bay (RI, USA) Ulva (Ulvales, Chlorophyta) populations.

    Science.gov (United States)

    Guidone, Michele; Thornber, Carol; Wysor, Brian; O'Kelly, Charles J

    2013-10-01

    Macroalgal bloom-forming species occur in coastal systems worldwide. However, due to overlapping morphologies in some taxa, accurate taxonomic assessment and classification of these species can be quite challenging. We investigated the molecular and morphological characteristics of 153 specimens of bloom-forming Ulva located in and around Narragansett Bay, RI, USA. We analyzed sequences of the nuclear internal transcribed spacer 1 region (ITS1) and the chloroplast-encoded rbcL; based on the ITS1 data, we grouped the specimens into nine operational taxonomic units (OTUs). Eight of these OTUs have been previously reported to exist, while one is novel. Of the eight OTUs, all shared sequence identity with previously published sequences or differed by less than 1.5% sequence divergence for two molecular markers. Previously, 10 species names were reported for Ulva in Rhode Island (one blade and nine tube-forming species) based upon morphological classification alone. Of our nine OTUs, three contained blade-forming specimens (U. lactuca, U. compressa, U. rigida), one OTU had a blade with a tubular stipe, and six contained unbranched and/or branched tubular morphologies (one of these six, U. compressa, had both a blade and a tube morphology). While the three blade-forming OTUs in Narragansett Bay can frequently be distinguished by careful observations of morphological characteristics, and spatial/temporal distribution, it is much more difficult to distinguish among the tube-forming specimens based upon morphology or distribution alone. Our data support the molecular species concept for Ulva, and indicate that molecular-based classifications of Ulva species are critical for proper species identification, and subsequent ecological assessment or mitigation of Ulva blooms. © 2013 Phycological Society of America.

  9. A network of networks.

    Science.gov (United States)

    Iedema, Rick; Verma, Raj; Wutzke, Sonia; Lyons, Nigel; McCaughan, Brian

    2017-04-10

    Purpose To further our insight into the role of networks in health system reform, the purpose of this paper is to investigate how one agency, the NSW Agency for Clinical Innovation (ACI), and the multiple networks and enabling resources that it encompasses, govern, manage and extend the potential of networks for healthcare practice improvement. Design/methodology/approach This is a case study investigation which took place over ten months through the first author's participation in network activities and discussions with the agency's staff about their main objectives, challenges and achievements, and with selected services around the state of New South Wales to understand the agency's implementation and large system transformation activities. Findings The paper demonstrates that ACI accommodates multiple networks whose oversight structures, self-organisation and systems change approaches combined in dynamic ways, effectively yield a diversity of network governances. Further, ACI bears out a paradox of "centralised decentralisation", co-locating agents of innovation with networks of implementation and evaluation expertise. This arrangement strengthens and legitimates the role of the strategic hybrid - the healthcare professional in pursuit of change and improvement, and enhances their influence and impact on the wider system. Research limitations/implications While focussing the case study on one agency only, this study is unique as it highlights inter-network connections. Contributing to the literature on network governance, this paper identifies ACI as a "network of networks" through which resources, expectations and stakeholder dynamics are dynamically and flexibly mediated and enhanced. Practical implications The co-location of and dynamic interaction among clinical networks may create synergies among networks, nurture "strategic hybrids", and enhance the impact of network activities on health system reform. Social implications Network governance requires more

  10. Comparison of a Gas Chromatograph and a Cavity Ringdown Spectrometer for Flux Quantification of Nitrous Oxide, Carbon Dioxide and Methane in Closed Soil Chambers Derek Fleck1, Yonggang He1, Donald Herman2, Serena Moseman-Valtierra3, Gloria Jacobson1 1 Picarro Inc, 3105 Patrick Henry Drive, Santa Clara, CA 95054 2 College of Natural Resource, UC Berkeley, 130 Mulford Hall, University of California, Berkeley, CA, 94720-3114 3 University of Rhode Island, CBLS 489, Kingston, RI 02881

    Science.gov (United States)

    Fleck, D.; He, Y.; Herman, D.; Moseman-valtierra, S.; Jacobson, G. A.

    2013-12-01

    The study of the three predominant greenhouse gasses effecting global climate change, CO2, CH4 and N2O, has become increasingly important in ecological and agricultural soil research. It is essential for current and future atmospheric greenhouse gas budgets to reduce the uncertainty of greenhouse gas soil fluxes in a variety of environments and climates. Traditional soil flux experiments using the closed chamber and discrete sampling for Gas Chromatograph ('GC') analysis cannot sufficiently capture the large temporal variation in soil gas fluxes, which can lead to large errors in ecosystem flux models. Real-time, simultaneous measurement of these gases should provide easier and more comprehensive and precise chamber flux measurements. We provide a comparison of the GC sampling method to a closed loop, continuous flow system coupled with a Picarro G2508 Cavity Ringdown Spectrometer to quantify the flux of CO2, CH4 and N2O. The Picarro analyzer has a data rate of approximately 6 seconds for all three gases, which gives a much higher temporal resolution than discrete sampling (performed every 8-15 minutes). This work will compare GC and Picarro G2508 soil flux measurement results from two independent researchers and will cover fluxes for three different soil environments. Details on the system configuration and sampling methodology effects on flux errors will also be discussed. We will show that by reducing the systematic error due to sample preparation for the GC, the continuous flow measurement of the Picarro G2508 field deployable analyzer can significantly increase the measurement precision of respiration rates of N2O, CH4 and CO2. It is noteworthy that the Picarro analyzer also simultaneously measures the concentration of ammonia (NH3) and water, and these results will also be discussed.

  11. Generation of canine-human Fc IgE chimeric antibodies for the determination of the canine IgE domain of interaction with Fc epsilon RI alpha.

    Science.gov (United States)

    Hunter, Michael J; Vratimos, Athanassios P; Housden, Jonathan E M; Helm, Birgit A

    2008-04-01

    Identification of the domain(s) of canine IgE that interact with Fc epsilon RI alpha may lead to novel therapeutic intervention strategies that inhibit the ability of canine IgE to engage Fc epsilon RI alpha. A panel of canine-human Fc IgE chimeric antibodies was constructed to investigate this interaction by replacing canine IgE-Fc domains with the corresponding human IgE-Fc domains since human IgE-Fc does not recognize canine Fc epsilon RI alpha. beta-Hexosaminidase release assays were performed to assess the ability of the chimeric antibodies to bind to and sensitize a novel RBL cell line transfected with canine Fc epsilon RI alpha for antigen induced mediator release. Replacing canine C epsilon2 with human C epsilon2 resulted in similar levels of release as those elicited by canine Fc IgE from RBL-2H3 cells transfected with either canine Fc epsilon RI alpha or human Fc epsilon RI alpha. Substitution of canine C epsilon4 with human C epsilon4 resulted in approximately 10% lower levels of release compared to cells sensitized with canine Fc IgE. Receptor binding by flow cytometry and cell activation could not be detected when transfected RBL cells were incubated with chimeric constructs where canine C epsilon2 and C epsilon4 were substituted with human C epsilon2 and C epsilon4. However, when this construct was incubated with cognate antigen prior to cell challenge mediator release was observed, albeit at a 20% lower level, indicating that while canine C epsilon3 is the only domain essential for binding to canine or human Fc epsilon RI alpha, species specific residues in canine Cepsilon2 and C epsilon4 inhibit dissociation of the ligand from the receptor.

  12. Engineered selective plant male sterility through pollen-specific expression of the EcoRI restriction endonuclease.

    Science.gov (United States)

    Millwood, Reginald J; Moon, Hong S; Poovaiah, Charleson R; Muthukumar, Balasubramaniam; Rice, John Hollis; Abercrombie, Jason M; Abercrombie, Laura L; Green, William Derek; Stewart, Charles Neal

    2016-05-01

    Unintended gene flow from transgenic plants via pollen, seed and vegetative propagation is a regulatory concern because of potential admixture in food and crop systems, as well as hybridization and introgression to wild and weedy relatives. Bioconfinement of transgenic pollen would help address some of these concerns and enable transgenic plant production for several crops where gene flow is an issue. Here, we demonstrate the expression of the restriction endonuclease EcoRI under the control of the tomato pollen-specific LAT52 promoter is an effective method for generating selective male sterility in Nicotiana tabacum (tobacco). Of nine transgenic events recovered, four events had very high bioconfinement with tightly controlled EcoRI expression in pollen and negligible-to-no expression other plant tissues. Transgenic plants had normal morphology wherein vegetative growth and reproductivity were similar to nontransgenic controls. In glasshouse experiments, transgenic lines were hand-crossed to both male-sterile and emasculated nontransgenic tobacco varieties. Progeny analysis of 16 000-40 000 seeds per transgenic line demonstrated five lines approached (>99.7%) or attained 100% bioconfinement for one or more generations. Bioconfinement was again demonstrated at or near 100% under field conditions where four transgenic lines were grown in close proximity to male-sterile tobacco, and 900-2100 seeds per male-sterile line were analysed for transgenes. Based upon these results, we conclude EcoRI-driven selective male sterility holds practical potential as a safe and reliable transgene bioconfinement strategy. Given the mechanism of male sterility, this method could be applicable to any plant species. © 2015 Society for Experimental Biology, Association of Applied Biologists and John Wiley & Sons Ltd.

  13. Naeruse lause huligaansest tõetruudusest, Jüri Üdi näitel / On Laughter, Truthfulness, and Hooliganism as Unfolded in the Writings of Jüri Üdi

    Directory of Open Access Journals (Sweden)

    Liisi Rünkla

    2013-12-01

    Full Text Available The writings of Jüri Üdi (alter ego of Estonian poet and actor Juhan Viiding, from 1968 to 1978 display the reality of something that could be referred to as a joyful dimension of anguish. Using four different (yet connected conceptual frames, this study seeks to observe how that dimension is created through play with and within words. Hando Runnel (1975 has described Jüri Üdi’s word artistry as walking on language. From this description and others, Hasso Krull has derived the concept of decentred affirmation (1998, as pure expression (1991, encouraging one to thus consider the process of expression as essentially conditioned by language. In biosemiotic intuition, language use is considered as unconditionally transparent as any other living process, while life tends to express in its current form all of its memory (its history of creating surfaces. To some extent, the works of Mikhail Bakhtin (1934, and others have already deeply inscribed this intuition into the discourses of literary theory, observing how language use is ever polyphonic, therefore polylogical; keeping several voices in play, at once laughing and true to its most deeply cherished ideals; tradition-bound; always already to quote another, in anticipation of the other’s response. This study is intentionally written in an elusive manner, deeply influenced (perhaps indirectly as well via Franz Kafka and Jacques Derrida by Søren Kierkegaard’s incessant emphasis (1843 on singularities ever introducing ruptures in language-bound life, inventing thresholds, drawing lines of flight via paradox, via the absurd, and by the beautifully exemplary manner in which Kierkegaard’s pseudonymous discourse embodies undecidability. This study does not seek to explain how the writings of Jüri Üdi perplex or enchant. Perplexed and enchanted, this study focuses rather on subjects of a more general nature, such as the conditions of writing (truthfully, through laughter as observed within

  14. Anti-Ri-associated paraneoplastic brainstem cerebellar syndrome with coexisting limbic encephalitis in a patient with mixed large cell neuroendocrine lung carcinoma.

    Science.gov (United States)

    Mitchell, Amber N; Bakhos, Charles T; Zimmerman, Earl A

    2015-02-01

    Paraneoplastic neurologic syndromes (PNS) can be the first manifestations of occult malignancies. If left untreated, PNS often lead to significant morbidity and mortality. Anti-Ri (anti-neuronal nuclear antibody type 2 [ANNA-2]) autoantibodies are commonly associated with breast and small cell lung cancers. Cases of anti-Ri paraneoplastic cerebellar degeneration are reported, but few describe severe nausea and coexisting limbic encephalitis as the major presenting features. We report a 75-year-old woman with medically-intractable emesis, encephalopathy, diplopia, vertigo, and gait ataxia for 3 months. Examination revealed rotary nystagmus, ocular skew deviation, limb dysmetria, and gait ataxia. After two courses of intravenous immunoglobulin, there was minimal improvement. Anti-Ri antibodies were positive in serum only. CT scan identified a 2.0 cm left lung mass, and histopathology revealed large cell neuroendocrine carcinoma with admixed adenocarcinoma non-small cell lung carcinoma (NCSLC). Though the patient achieved nearly complete clinical recovery after tumor resection, anti-Ri levels remained high at 20 months post-resection. To our knowledge this is the first report of a paraneoplastic brainstem cerebellar syndrome with coexisting limbic encephalitis involving anti-Ri positivity and associated mixed neuroendocrine/NSCLC of the lung with marked improvement after tumor resection. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. The relationship between aldosterone to renin ratio and RI value of the uterine artery in the preeclamptic patient vs. normal pregnancy.

    Science.gov (United States)

    Kim, Euy Hyuk; Lim, Jay Hak; Kim, Young Han; Park, Yong Won

    2008-02-29

    Plasma levels of renin, angiotensin II and aldosterone are increased during normal pregnancy. However, these values in preeclampsia are decreased to nearly that of a nonpregnant subject, and vascular sensitivity to angiotensin II is increased. In preeclampsia, aldosterone is decreased less than rennin. Therefore current studies were undertaken to determine the relationship between aldosterone to renin ratio (ARR) and uterine artery perfusion via RI value. In this study, the relationship between plasma aldosterone and renin concentration was determined in 27 preeclamptic women and 50 normal pregnant women, whose gestational weeks were matched. The aldosterone to renin ratio was calculated and compared between the two groups. Doppler velocimetry of the uterine artery, which was used to calculate resistance index (RI), was performed on all subjects. The relationship between ARR and RI value was reviewed. In the preeclampsia group, RI value of the uterine artery was significantly higher than that of normal pregnant women. Both plasma renin and aldosterone concentrations were lower in the preeclampsia group. However, the ratio of these two parameters was significantly higher (38.3 vs. 16.1, p RI of the uterine artery (r2 = 0.053, p = 0.048). This study demonstrates that a high aldosterone to renin ratio may have a negative effect on perfusion of the uterine artery and play an important role in the pathophysiology of preeclampsia.

  16. Site directed mutagenesis experiments suggest that Glu 111, Glu 144 and Arg 145 are essential for endonucleolytic activity of EcoRI.

    Science.gov (United States)

    Wolfes, H; Alves, J; Fliess, A; Geiger, R; Pingoud, A

    1986-11-25

    We have constructed a plasmid (pRIF 309+) carrying the EcoRI restriction endonuclease gene and the f1 origin of replication. Upon transformation of this plasmid into E. coli and infection with bacteriophage f1 single stranded plasmids are produced which can be used for sequencing and site directed mutagenesis. Using this single stranded DNA and synthetic oligodeoxynucleotides we have introduced point mutations at defined positions of the EcoRI gene. Since in pRIF309+ the EcoRI gene is under the control of the pL-promoter, high level expression of the mutated EcoRI gene could be obtained upon induction. Mutant EcoRI enzymes were purified to homogeneity and characterized in structural and functional terms. Our results demonstrate that the Glu 111----Gln, Glu 144----Gln and Arg 145----Lys -mutants adopt a very similar conformation as the wild type enzyme, but have by two orders of magnitude smaller specific activities than the wild type enzyme, mainly due to a reduction of the Vmax-value.

  17. BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells.

    Directory of Open Access Journals (Sweden)

    Wei Cao

    2007-09-01

    Full Text Available Dendritic cells are equipped with lectin receptors to sense the extracellular environment and modulate cellular responses. Human plasmacytoid dendritic cells (pDCs uniquely express blood dendritic cell antigen 2 (BDCA2 protein, a C-type lectin lacking an identifiable signaling motif. We demonstrate here that BDCA2 forms a complex with the transmembrane adapter Fc epsilon RI gamma. Through pathway analysis, we identified a comprehensive signaling machinery in human pDCs, similar to that which operates downstream of the B cell receptor (BCR, which is distinct from the system involved in T cell receptor (TCR signaling. BDCA2 crosslinking resulted in the activation of the BCR-like cascade, which potently suppressed the ability of pDCs to produce type I interferon and other cytokines in response to Toll-like receptor ligands. Therefore, by associating with Fc epsilon RI gamma, BDCA2 activates a novel BCR-like signaling pathway to regulate the immune functions of pDCs.

  18. Evidences for balancing selection from PAH-BglII and PAH-EcoRI polymorphisms in Isfahan population

    Directory of Open Access Journals (Sweden)

    Zahra Fazeli Attar

    2010-01-01

    Full Text Available Two polymorphic markers including BglII and EcoRI, were identified at intron 1 and intron 5 of PAH gene. In order to test whether these polymorphisms are behaving as neutral alleles or are being subjected to selective pressures in Isfahan population, 110 individuals were genotyped by PCR-RFLP. The Arlequin input file was prepared by use of phase-known haplotype data and Neutrality tests (Tajima D test and Fu’s Fs test were done using Arlequin program. 42 individuals were found heterozygous for both polymorphisms whose haplotype phase remained unknown. The BglII-EcoRI haplotype phase was known only at 68 individuals who were used for preparation of input file. Tajima's D value and Fs value at Isfahan population were 1.7 and 1.02, respectively. Positive values of Fs and D>0 indicated that these polymorphisms are under selection pressure at Isfahan population. Although these polymorphisms were in the non-coding region of PAH gene, but these were not neutral alleles and positive values of these tests provided evidence for balancing selection of these polymorphisms at Isfahan population. The results of this study could improve our understanding of evolutionary history and structure of Isfahan population.

  19. IgE/FcεRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances Anti-Tumor Immune Responses

    Directory of Open Access Journals (Sweden)

    Barbara Platzer

    2015-03-01

    Full Text Available Epidemiologic studies discovered an inverse association between immunoglobulin E (IgE-mediated allergies and cancer, implying tumor-protective properties of IgE. However, the underlying immunologic mechanisms remain poorly understood. Antigen cross-presentation by dendritic cells (DCs is of key importance for anti-tumor immunity because it induces the generation of cytotoxic CD8+ T lymphocytes (CTLs with specificity for tumor antigens. We demonstrate that DCs use IgE and FcεRI, the high-affinity IgE receptor, for cross-presentation and priming of CTLs in response to free soluble antigen at low doses. Importantly, IgE/FcεRI-mediated cross-presentation is a distinct receptor-mediated pathway because it does not require MyD88 signals or IL-12 induction in DCs. Using passive immunization with tumor antigen-specific IgE and DC-based vaccination experiments, we demonstrate that IgE-mediated cross-presentation significantly improves anti-tumor immunity and induces memory responses in vivo. Our findings suggest a cellular mechanism for the tumor-protective features of IgE and expand the known physiological functions of this immunoglobulin.

  20. The Cost and Threshold Analysis of Retention in Care (RiC): A Multi-Site National HIV Care Program.

    Science.gov (United States)

    Maulsby, Catherine; Jain, Kriti M; Weir, Brian W; Enobun, Blessing; Riordan, Maura; Charles, Vignetta E; Holtgrave, David R

    2017-03-01

    Persons diagnosed with HIV but not retained in HIV medical care accounted for the majority of HIV transmissions in 2009 in the United States (US). There is an urgent need to implement and disseminate HIV retention in care programs; however little is known about the costs associated with implementing retention in care programs. We assessed the costs and cost-saving thresholds for seven Retention in Care (RiC) programs implemented in the US using standard methods recommended by the US Panel on Cost-effectiveness in Health and Medicine. Data were gathered from accounting and program implementation records, entered into a standardized RiC economic analysis spreadsheet, and standardized to a 12 month time frame. Total program costs for from the societal perspective ranged from $47,919 to $423,913 per year or $146 to $2,752 per participant. Cost-saving thresholds ranged from 0.13 HIV transmissions averted to 1.18 HIV transmission averted per year. We estimated that these cost-saving thresholds could be achieved through 1 to 16 additional person-years of viral suppression. Across a range of program models, retention in care interventions had highly achievable cost-saving thresholds, suggesting that retention in care programs are a judicious use of resources.

  1. A Lanthipeptide-like N-Terminal Leader Region Guides Peptide Epimerization by Radical SAM Epimerases: Implications for RiPP Evolution.

    Science.gov (United States)

    Fuchs, Sebastian W; Lackner, Gerald; Morinaka, Brandon I; Morishita, Yohei; Asai, Teigo; Riniker, Sereina; Piel, Jörn

    2016-09-26

    Ribosomally synthesized and posttranslationally modified peptide natural products (RiPPs) exhibit diverse structures and bioactivities and are classified into distinct biosynthetic families. A recently reported family is the proteusins, with the prototype members polytheonamides being generated by almost 50 maturation steps, including introduction of d-residues at multiple positions by an unusual radical SAM epimerase. A region in the protein-like N-terminal leader of proteusin precursors is identified that is crucial for epimerization. It resembles a precursor motif previously shown to mediate interaction in thioether bridge-formation in class I lanthipeptide biosynthesis. Beyond this region, similarities were identified between proteusin and further RiPP families, including class I lanthipeptides. The data suggest that common leader features guide distinct maturation types and that nitrile hydratase-like enzymes are ancestors of several RiPP classes. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Declarative Networking

    CERN Document Server

    Loo, Boon Thau

    2012-01-01

    Declarative Networking is a programming methodology that enables developers to concisely specify network protocols and services, which are directly compiled to a dataflow framework that executes the specifications. Declarative networking proposes the use of a declarative query language for specifying and implementing network protocols, and employs a dataflow framework at runtime for communication and maintenance of network state. The primary goal of declarative networking is to greatly simplify the process of specifying, implementing, deploying and evolving a network design. In addition, decla

  3. Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI

    OpenAIRE

    Sabban, Sari; Ye, Hongtu; Helm, Birgit

    2014-01-01

    The interaction of IgE with its high-affinity Fc receptor (FcεRI) followed by an antigenic challenge is the principal pathway in IgE mediated allergic reactions. As a consequence of the high affinity binding between IgE and FcεRI, along with the continuous production of IgE by B cells, allergies usually persist throughout life, with currently no permanent cure available. Horses, especially race horses, which are commonly inbred, are a species of mammals that are very prone to the development ...

  4. Unelõiv ja Saarepiiga: Jüri Talveti kirjanduslik "Kalevipoeg" / The Rhisomes of „Kalevipoeg“: Literary Interpretation of the Estonian National Epic by Jüri Talvet

    Directory of Open Access Journals (Sweden)

    Marin Laak

    2016-12-01

    Full Text Available Teesid: Artikkel keskendub eepose „Kalevipoeg“ käsitlusele võrdleva kirjandusteaduse vaatepunktist. „Kalevipoja“ uurimine ilukirjandusliku teosena muutis paradigmaatiliselt rahvuseepose senist tõlgendust ja seda tänu Jüri Talveti käsitlustele „Kalevipojast“ kui suurest Euroopa eeposest, silmapaistavast maailmakirjanduse kunsteeposte seas. Eepose teksti ja poeetika kirjandusteaduslik uurimine on selgitanud, kuidas eepose tekst on üles ehitatud sisemistele, intratekstuaalsetele seostele, mis korduvad gradatsiooniliselt ja toetuvad teatud kindlatele tekstuaalsetele sõlmpunktidele, näiteks „Saarepiiga“, „uni“ jpt. Enam kui autentsed allikad, on „Kalevipoja“ kui kirjandusliku teksti puhul oluline eepose toimimine pidevalt uusi tekste ärgitava tüvitekstina. Eepose analüüs näitab, kuidas selliste seoste alusel tekivad uued kultuurilised ühikud, kauneid näiteid selliste motiivikordustele rajatud seosteahelate kohta leidub ka Jüri Talveti luules.   The article focuses on the treatment of the epic The Kalevipoeg from the viewpoint of comparative literature. This approach is a continuation of the study of literary relations of the epic which, on the one hand is opposite to, but on the other hand continues the present folkloristic approach to The Kalevipoeg as a folklore-based epic, which is based on the comparative-historical method of studying folklore. F. R. Kreutzwald’s role in creating the national epic was enormous; the epic can be conceived as a fictional and intentional piece, emphasising the role of its author. Although different genres of genuine folklore can be recognised in the epic, works of fiction of European and world classics have also been used in its construction, and the text of the epic has itself become an intertextual foundation for new works of fiction. The paradigm of discussing the epic changed due to Jüri Talvet’s groundbreaking treatment of The Kalevipoeg as a great European epic and

  5. Targeting Allergen to FcγRI Reveals a Novel Th2 Regulatory Pathway Linked to TSLP Receptor

    Science.gov (United States)

    Hulse, Kathryn E.; Reefer, Amanda J.; Engelhard, Victor H.; Patrie, James T.; Ziegler, Steven F.; Chapman, Martin D.; Woodfolk, Judith A.

    2009-01-01

    Background The molecule H22-Fel d 1, which targets cat allergen to FcγRI on dendritic cells, has the potential to treat cat allergy owing to its T-cell modulatory properties. Objective To investigate whether the T-cell response induced by H22-Fel d 1 is altered in the presence of the Th2-promoting cytokine, TSLP. Methods Studies were performed in cat-allergic subjects with and without atopic dermatitis. Monocyte-derived dendritic cells were primed with H22-Fel d 1 in the presence or absence of TSLP and the resulting T-cell cytokine repertoire was analyzed by flow cytometry. The capacity for H22-Fel d 1 to modulate TSLP receptor expression on dendritic cells was examined by flow cytometry in the presence or absence of inhibitors of Fc receptor signaling molecules. Results Surprisingly, TSLP alone was a weak inducer of Th2 responses irrespective of atopic status; however, dendritic cells co-primed with TSLP and H22-Fel d 1 selectively and synergistically amplified Th2 responses in highly atopic subjects. This effect was OX40 ligand-independent pointing to an unconventional TSLP-mediated pathway. Expression of TSLP receptor was upregulated on atopic dendritic cells primed with H22-Fel d 1 through a pathway regulated by FcγRI-associated signaling components, including src related tyrosine kinases and Syk, as well as the downstream molecule, PI3-kinase. Inhibition of TSLP receptor upregulation triggered by H22-Fel d 1 blocked TSLP-mediated Th2 responses. Conclusion Discovery of a novel Th2 regulatory pathway linking FcγRI signaling to TSLP receptor upregulation and consequent TSLP-mediated effects questions the validity of receptor-targeted allergen vaccines. Clinical Implications This study establishes a pivotal role for Fc receptor ligation in promoting TSLP-mediated Th2 responses associated with allergic disease. Capsule Summary Atopic dendritic cells are equipped to efficiently upregulate TSLP receptor upon Fc receptor ligation by allergen. These findings suggest

  6. Anna Lampérière, solidarité et citoyenneté féminine sous la Troisième République

    Directory of Open Access Journals (Sweden)

    Anne R. Epstein

    2008-12-01

    Full Text Available Cet article examine les idées de l’institutrice Anna Lampérière, l’une des rares femmes à avoir contribué à la discussion théorique sur l’idéologie de la solidarité pendant la Troisième République. Vue dans le contexte de son parcours personnel et de son engagement civique, la pensée d’A. Lampérière offre un aperçu inédit d’un modèle solidariste de citoyenneté féminine sans droit de vote. Au sein d’une culture d’associations florissante au début du XXe siècle, elle participe à la création et au fonctionnement d’importantes associations mixtes qui, par l’éducation civique, visent la mise en place de l’idéologie solidariste de Léon Bourgeois. Se proclamant anti-féministe, Anna Lampérière se présente néanmoins comme une défenseuse de la cause des femmes et du progrès social et, comme beaucoup de ses contemporains, elle place la réforme scolaire au cœur de son projet républicain. Après une analyse de la vision sociale d’Anna Lampérière, l’article examine les pratiques civiques et la structure mixte selon les sexes de la Société pour l’éducation sociale, une association pour la promotion du solidarisme, dont elle a été Secrétaire générale. L’idéologie solidariste et sa pratique avaient un attrait pour des femmes républicaines comme Anna Lampérière qui avaient une vocation civique mais qui n’étaient pas attirées par un modèle égalitaire de la citoyenneté.Anna Lampérière, solidarité and female citizenship in the Third Republic This article explores the ideas of educator Anna Lampérière, one of the rare women to contribute significantly to the theoretical discussion about the ideology of solidarity during the Third Republic. Viewed in tandem with her own personal history and civic activism, Lampérière’s thought provides unique insight into a possible solidarist model of female citizenship without voting rights. Operating within the flourishing associational

  7. MARSnet: Mission-aware Autonomous Radar Sensor Network for Future Combat Systems

    Science.gov (United States)

    2009-03-23

    Nevertheless, as an additional source of error, the in- terference from external network also play an important role in defining the quality of the link. To...beamformer at the receiver antenna is V = ££i Ane*»i-*«>£.« T.yiX*eH*7-**)E,8 E"l^M<jl^~"N)EsS + II (21) 16 Whore Es >> a 2{ri). In MIMO radar for

  8. Äriühingud : nende asutamise õiguslik regulatsioon : ajaloolis-võrdlev analüüs (Saksa, Soome ja Euroopa Liit) : [bakalaureusetöö] / Kaire Reispass ; Akadeemia Nord, õigusteaduskond ; juhendaja: Enno Oidermaa

    Index Scriptorium Estoniae

    Reispass, Kaire

    1999-01-01

    Äriühingute olemus ja asutamise alused kehtivas seadustikus, Eesti ettevõtlust reguleeriva õigusloome ajalooline ja võrdlev ülevaade, võrdlev ülevaade Saksa, Soome ja Euroopa Liidu äriühinguõigusest

  9. LoFEx — A local framework for calculating excitation energies: Illustrations using RI-CC2 linear response theory

    Science.gov (United States)

    Baudin, Pablo; Kristensen, Kasper

    2016-06-01

    We present a local framework for the calculation of coupled cluster excitation energies of large molecules (LoFEx). The method utilizes time-dependent Hartree-Fock information about the transitions of interest through the concept of natural transition orbitals (NTOs). The NTOs are used in combination with localized occupied and virtual Hartree-Fock orbitals to generate a reduced excitation orbital space (XOS) specific to each transition where a standard coupled cluster calculation is carried out. Each XOS is optimized to ensure that the excitation energies are determined to a predefined precision. We apply LoFEx in combination with the RI-CC2 model to calculate the lowest excitation energies of a set of medium-sized organic molecules. The results demonstrate the black-box nature of the LoFEx approach and show that significant computational savings can be gained without affecting the accuracy of CC2 excitation energies.

  10. Function of the aux and rol genes of the Ri plasmid in plant cell division in vitro.

    Science.gov (United States)

    Nemoto, Keiichirou; Hara, Masamitsu; Suzuki, Masashi; Seki, Hikaru; Oka, Atsuhiro; Muranaka, Toshiya; Mano, Yoshihiro

    2009-12-01

    Auxin-autonomous growth in vitro may be related to the integration and expression of the aux and rol genes from the root-inducing (Ri) plasmid in plant cells infected by agropine-type Agrobacterium rhizogenes. To elucidate the functions of the aux and rol genes in plant cell division, plant cell lines transformed with the aux1 and aux2 genes or with the rolABCD genes were established using tobacco (Nicotiana tabacum) Bright Yellow-2 (BY-2) cells. The introduction of the aux1 and aux2 genes enabled the auxin-autonomous growth of BY-2 cells, but the introduction of the rolABCD genes did not affect the auxin requirement of the BY-2 cells. The results clearly show that the aux genes are necessary for auxinautotrophic cell division, and that the rolABCD genes are irrelevant in auxin autotrophy.

  11. First test experiment to produce the slowed-down RI beam with the momentum-compression mode at RIBF

    Energy Technology Data Exchange (ETDEWEB)

    Sumikama, T., E-mail: sumikama@ribf.riken.jp [RIKEN Nishina Center, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Department of Physics, Tohoku University, Aoba, Sendai 980-8578 (Japan); Ahn, D.S.; Fukuda, N.; Inabe, N.; Kubo, T.; Shimizu, Y.; Suzuki, H.; Takeda, H. [RIKEN Nishina Center, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Aoi, N. [Research Center for Nuclear Physics, Osaka University, Ibaraki, Osaka 567-0047 (Japan); Beaumel, D. [Institut de Physique Nucléaire d’Orsay (IPNO), CNRS/IN2P3, 91405 Orsay (France); Hasegawa, K. [Department of Physics, Tohoku University, Aoba, Sendai 980-8578 (Japan); Ideguchi, E. [Research Center for Nuclear Physics, Osaka University, Ibaraki, Osaka 567-0047 (Japan); Imai, N. [Center for Nuclear Study, University of Tokyo, RIKEN Campus, 2-1 Hirosawa, Wako, Saitama 351-0298 (Japan); Kobayashi, T. [Department of Physics, Tohoku University, Aoba, Sendai 980-8578 (Japan); Matsushita, M.; Michimasa, S. [Center for Nuclear Study, University of Tokyo, RIKEN Campus, 2-1 Hirosawa, Wako, Saitama 351-0298 (Japan); Otsu, H. [RIKEN Nishina Center, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Shimoura, S. [Center for Nuclear Study, University of Tokyo, RIKEN Campus, 2-1 Hirosawa, Wako, Saitama 351-0298 (Japan); Teranishi, T. [Department of Physics, Kyushu University, 6-10-1 Hakozaki, Fukuoka 812-8581 (Japan)

    2016-06-01

    The {sup 82}Ge beam has been produced by the in-flight fission reaction of the {sup 238}U primary beam with 345 MeV/u at the RIKEN RI beam factory, and slowed down to about 15 MeV/u using the energy degraders. The momentum-compression mode was applied to the second stage of the BigRIPS separator to reduce the momentum spread. The energy was successfully reduced down to 13 ± 2.5 MeV/u as expected. The focus was not optimized at the end of the second stage, therefore the beam size was larger than the expectation. The transmission of the second stage was half of the simulated value mainly due to out of focus. The two-stage separation worked very well for the slowed-down beam with the momentum-compression mode.

  12. Comparing RIEGL RiCOPTER UAV LiDAR Derived Canopy Height and DBH with Terrestrial LiDAR.

    Science.gov (United States)

    Brede, Benjamin; Lau, Alvaro; Bartholomeus, Harm M; Kooistra, Lammert

    2017-10-17

    In recent years, LIght Detection And Ranging (LiDAR) and especially Terrestrial Laser Scanning (TLS) systems have shown the potential to revolutionise forest structural characterisation by providing unprecedented 3D data. However, manned Airborne Laser Scanning (ALS) requires costly campaigns and produces relatively low point density, while TLS is labour intense and time demanding. Unmanned Aerial Vehicle (UAV)-borne laser scanning can be the way in between. In this study, we present first results and experiences with the RIEGL RiCOPTER with VUX ® -1UAV ALS system and compare it with the well tested RIEGL VZ-400 TLS system. We scanned the same forest plots with both systems over the course of two days. We derived Digital Terrain Model (DTMs), Digital Surface Model (DSMs) and finally Canopy Height Model (CHMs) from the resulting point clouds. ALS CHMs were on average 11.5 c m higher in five plots with different canopy conditions. This showed that TLS could not always detect the top of canopy. Moreover, we extracted trunk segments of 58 trees for ALS and TLS simultaneously, of which 39 could be used to model Diameter at Breast Height (DBH). ALS DBH showed a high agreement with TLS DBH with a correlation coefficient of 0.98 and root mean square error of 4.24 c m . We conclude that RiCOPTER has the potential to perform comparable to TLS for estimating forest canopy height and DBH under the studied forest conditions. Further research should be directed to testing UAV-borne LiDAR for explicit 3D modelling of whole trees to estimate tree volume and subsequently Above-Ground Biomass (AGB).

  13. Comparing RIEGL RiCOPTER UAV LiDAR Derived Canopy Height and DBH with Terrestrial LiDAR

    Directory of Open Access Journals (Sweden)

    Benjamin Brede

    2017-10-01

    Full Text Available In recent years, LIght Detection And Ranging (LiDAR and especially Terrestrial Laser Scanning (TLS systems have shown the potential to revolutionise forest structural characterisation by providing unprecedented 3D data. However, manned Airborne Laser Scanning (ALS requires costly campaigns and produces relatively low point density, while TLS is labour intense and time demanding. Unmanned Aerial Vehicle (UAV-borne laser scanning can be the way in between. In this study, we present first results and experiences with the RIEGL RiCOPTER with VUX ® -1UAV ALS system and compare it with the well tested RIEGL VZ-400 TLS system. We scanned the same forest plots with both systems over the course of two days. We derived Digital Terrain Model (DTMs, Digital Surface Model (DSMs and finally Canopy Height Model (CHMs from the resulting point clouds. ALS CHMs were on average 11.5 c m higher in five plots with different canopy conditions. This showed that TLS could not always detect the top of canopy. Moreover, we extracted trunk segments of 58 trees for ALS and TLS simultaneously, of which 39 could be used to model Diameter at Breast Height (DBH. ALS DBH showed a high agreement with TLS DBH with a correlation coefficient of 0.98 and root mean square error of 4.24 c m . We conclude that RiCOPTER has the potential to perform comparable to TLS for estimating forest canopy height and DBH under the studied forest conditions. Further research should be directed to testing UAV-borne LiDAR for explicit 3D modelling of whole trees to estimate tree volume and subsequently Above-Ground Biomass (AGB.

  14. SaFaRI: sacral nerve stimulation versus the FENIX magnetic sphincter augmentation for adult faecal incontinence: a randomised investigation.

    Science.gov (United States)

    Williams, Annabelle E; Croft, Julie; Napp, Vicky; Corrigan, Neil; Brown, Julia M; Hulme, Claire; Brown, Steven R; Lodge, Jen; Protheroe, David; Jayne, David G

    2016-02-01

    Faecal incontinence is a physically, psychologically and socially disabling condition. NICE guidance (2007) recommends surgical intervention, including sacral nerve stimulation (SNS), after failed conservative therapies. The FENIX magnetic sphincter augmentation (MSA) device is a novel continence device consisting of a flexible band of interlinked titanium beads with magnetic cores that is placed around the anal canal to augment anal sphincter tone through passive attraction of the beads. Preliminary studies suggest the FENIX MSA is safe, but efficacy data is limited. Rigorous evaluation is required prior to widespread adoption. The SaFaRI trial is a National Institute of Health Research (NIHR) Health Technology Assessment (HTA)-funded UK multi-site, parallel group, randomised controlled, unblinded trial that will investigate the use of the FENIX MSA, as compared to SNS, for adult faecal incontinence resistant to conservative management. Twenty sites across the UK, experienced in the treatment of faecal incontinence, will recruit 350 patients randomised equally to receive either SNS or FENIX MSA. Participants will be followed-up at 2 weeks post-surgery and at 6, 12 and 18 months post-randomisation. The primary endpoint is success, as defined by device in use and ≥50 % improvement in the Cleveland Clinic Incontinence Score (CCIS) at 18 months post-randomisation. Secondary endpoints include complications, quality of life and cost effectiveness. SaFaRI will rigorously evaluate a new technology for faecal incontinence, the FENIX™ MSA, allowing its safe and controlled introduction into current clinical practice. These results will inform the future surgical management of adult faecal incontinence.

  15. Listeria monocytogenes in RTE foods marketed in Italy: prevalence and automated EcoRI ribotyping of the isolates.

    Science.gov (United States)

    Meloni, Domenico; Galluzzo, Pietro; Mureddu, Anna; Piras, Francesca; Griffiths, Mansel; Mazzette, Rina

    2009-02-15

    The aims of the present study were: (a) to investigate the prevalence and the enumeration of Listeria monocytogenes in 200 samples of ready to eat (RTE) foods of animal and vegetal origin collected from different outlets and processing plants in Sardinia; (b) to characterize the isolates by phenotypical and molecular methods; (c) to analyze a subset of 42 L. monocytogenes by automated EcoRI ribotyping in order to predict the strain's potential virulence for humans. The strains were isolated from: smoked fish products, cooked marinated products, meat products and pre-packaged mixed vegetable salads. Of the samples tested, 22% were positive for Listeria spp. The prevalence of L. monocytogenes was 9.5%, while the level of L. monocytogenes in the positive samples was 93%), belonging to 17 different DuPont Identification Library Codes (DUP-IDs) clones. The Simpson's numerical index of discrimination was 0.911. Cluster analysis pointed out a high similarity among strains isolated from meat, fish, and vegetables of different origin. These results confirmed the existence of a widespread population of L. monocytogenes, characterized by highly related strains existing in different geographical areas. 65% of these strains belonged to lineage II (serotypes 1/2a and 1/2c), subtypes known to be associated with sporadic human listeriosis outbreaks. The remaining 35% of the isolates (serotypes 1/2b, 3b and 4b) were allocated to lineage I and belong to distinct clonal groups (DUP-ID 1038 and 1042), which again have been associated with several outbreaks of human listeriosis. Neither atypical profiles nor lineage III strains were found. EcoRI ribotyping was confirmed as a rapid and reliable method for L. monocytogenes typing, providing useful data for epidemiologic and clonality surveys of L. monocytogenes strains isolated from RTE foods.

  16. The network researchers' network

    DEFF Research Database (Denmark)

    Henneberg, Stephan C.; Jiang, Zhizhong; Naudé, Peter

    2009-01-01

    The Industrial Marketing and Purchasing (IMP) Group is a network of academic researchers working in the area of business-to-business marketing. The group meets every year to discuss and exchange ideas, with a conference having been held every year since 1984 (there was no meeting in 1987). In thi......The Industrial Marketing and Purchasing (IMP) Group is a network of academic researchers working in the area of business-to-business marketing. The group meets every year to discuss and exchange ideas, with a conference having been held every year since 1984 (there was no meeting in 1987......). In this paper, based upon the papers presented at the 22 conferences held to date, we undertake a Social Network Analysis in order to examine the degree of co-publishing that has taken place between this group of researchers. We identify the different components in this database, and examine the large main...

  17. Structural insights into the interaction of human IgG1 with FcγRI: no direct role of glycans in binding

    Energy Technology Data Exchange (ETDEWEB)

    Oganesyan, Vaheh, E-mail: oganesyanv@medimmune.com; Mazor, Yariv; Yang, Chunning; Cook, Kimberly E.; Woods, Robert M. [MedImmune LLC, 1 MedImmune Way, Gaithersburg, MD 20878 (United States); Ferguson, Andrew [AstraZeneca Pharmaceuticals, 35 Gatehouse Drive, Mailstop E3, Waltham, MA 02451 (United States); Bowen, Michael A.; Martin, Tom; Zhu, Jie; Wu, Herren; Dall’Acqua, William F., E-mail: oganesyanv@medimmune.com [MedImmune LLC, 1 MedImmune Way, Gaithersburg, MD 20878 (United States)

    2015-10-31

    In an effort to identify the critical structural features responsible for the high-affinity interaction of IgG1 Fc with FcγRI, the structure of the corresponding complex was solved at a resolution of 2.4 Å. The three-dimensional structure of a human IgG1 Fc fragment bound to wild-type human FcγRI is reported. The structure of the corresponding complex was solved at a resolution of 2.4 Å using molecular replacement; this is the highest resolution achieved for an unmutated FcγRI molecule. This study highlights the critical structural and functional role played by the second extracellular subdomain of FcγRI. It also explains the long-known major energetic contribution of the Fc ‘LLGG’ motif at positions 234–237, and particularly of Leu235, via a ‘lock-and-key’ mechanism. Finally, a previously held belief is corrected and a differing view is offered on the recently proposed direct role of Fc carbohydrates in the corresponding interaction. Structural evidence is provided that such glycan-related effects are strictly indirect.

  18. Kuidas teie koolis tähistati õpetajate päeva? / Inna Lamp, Tõnu Soop, Jüri Toit ... [jt.

    Index Scriptorium Estoniae

    2011-01-01

    Küsimusele vastasid Pala kooli huvijuht Inna Lamp, Kärdla ühisgümnaasiumi õpetaja Tõnu Soop, Jõgeva ühisgümnaasiumi direktor Jüri Toit, Juuru gümnaasiumi direktor Sirje Kautsaar, Muhu põhikooli muusikaõpetaja Leena Peegel

  19. Äriühingu püsiv maksejõuetus ja edasiste maksete tegemine. Kus on piir keelatu ja lubatu vahel? / Triin Toom

    Index Scriptorium Estoniae

    Toom, Triin, 1990-

    2014-01-01

    Äriühingu püsiva maksejõuetuse kindlakstegemisest ning maksete tegemise piirangu sisust ja ulatusest. Eesti ja Saksamaa õigusreeglite ja kohtupraktika võrdlev analüüs. Artikkel põhineb autori magistritööl

  20. El Kalevipoeg, otra epopeya ignorada / Jüri Talvet ; [inglise keelest tlk. Giselle Lázaro ja Albert Lázaro Tinaut

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    2003-01-01

    Pealk. tõlge: "Kalevipoeg" - veel üks unustatud eepos. - Lisa: Fr. R. Kreutzwald. A la libertad : [Priiusele / tlk. Jüri Talvet ja Albert Lázaro Tinaut], lk. 35. Artikkel on eesti keeles ilmunud pealkirja ""Kalevipoeg" - suur Euroopa eepos" all.

  1. Isad ja tütred, isad ja pojad / Jüri Ross, Kristine Ross, Fjodor Berman ...[jt.] ; üles kirjutanud Jaana Liigand

    Index Scriptorium Estoniae

    2011-01-01

    Büroomaailma juht Jüri Ross ja turundusdirektor Kristine Ross, BLRT Grupi omanik Fjodor Berman ja BLRT Grupi tütarfirma Refonda tegevdirektor Mark Berman, Saaremaa Laevakompanii ja paljude firmade omanik Vjatšeslav Leedo ja Mosaiigi kohviku omanik Katrin Leedo ärist, juhtimisest ja omavahelistest suhetest

  2. Sügisnäituse vahetavad välja Jüri Arraku maalid / Aate-Heli Õun ; interv. Tiina Sarv

    Index Scriptorium Estoniae

    Õun, Aate-Heli, 1940-

    2008-01-01

    Näituse korraldajaga XVIII sügiskunstinäitusest ja seda välja vahetavast XVIII jõulunäitusest Viljandi kunstisaalis. Jõulunäitusel on Jüri Arraku maalid Kumu, Tartu Kunstimuuseumi ja Tallinna Kunstihoone kogudest

  3. Eesti tippteadlaste panus maailma : päästvad bakterid ja täiustatud elektroonika / koost. Jüri Allik

    Index Scriptorium Estoniae

    2007-01-01

    ri Allik lappas maailma suurimat teaduskirjanduse andmebaasi ISI Web of Science. Enimviidatud Eesti teadlased on: Jaan Aarik, Jaak Jürimäe, Mati Karelson, Marco Kirm, Eero Vasar, Mihkel Zilmer, Ülo Niinemets, Kaupo Kukli, Enn Lust

  4. Mida teha Tarmo Looduse olukorras? / Lukas, Tõnis; Ginter, Jüri; Raba, Rannar; Välis, Meelis; Lunter, Alli; Otepalu, Olavi

    Index Scriptorium Estoniae

    2008-01-01

    Küsimusele vastavad haridusminister Tõnis Lukas, Tartu ülikooli haridusteaduskonna prodekaan Jüri Ginter, "Sakala" arvamustoimetaja Rannar Raba, Kullamaa keskkooli direktor Meelis Välis, Viljandi maagümnaasiumi õpetaja Alli Lunter ja Audentese gümnaasiumi õppealajuhataja Olavi Otepalu

  5. FcɛRI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane

    Science.gov (United States)

    Nishida, Keigo; Yamasaki, Satoru; Ito, Yukitaka; Kabu, Koki; Hattori, Kotaro; Tezuka, Tohru; Nishizumi, Hirofumi; Kitamura, Daisuke; Goitsuka, Ryo; Geha, Raif S.; Yamamoto, Tadashi; Yagi, Takeshi; Hirano, Toshio

    2005-01-01

    The aggregation of high affinity IgE receptors (Fcɛ receptor I [FcɛRI]) on mast cells is potent stimulus for the release of inflammatory and allergic mediators from cytoplasmic granules. However, the molecular mechanism of degranulation has not yet been established. It is still unclear how FcɛRI-mediated signal transduction ultimately regulates the reorganization of the cytoskeleton and how these events lead to degranulation. Here, we show that FcɛRI stimulation triggers the formation of microtubules in a manner independent of calcium. Drugs affecting microtubule dynamics effectively suppressed the FcɛRI-mediated translocation of granules to the plasma membrane and degranulation. Furthermore, the translocation of granules to the plasma membrane occurred in a calcium-independent manner, but the release of mediators and granule–plasma membrane fusion were completely dependent on calcium. Thus, the degranulation process can be dissected into two events: the calcium-independent microtubule-dependent translocation of granules to the plasma membrane and calcium-dependent membrane fusion and exocytosis. Finally, we show that the Fyn/Gab2/RhoA (but not Lyn/SLP-76) signaling pathway plays a critical role in the calcium-independent microtubule-dependent pathway. PMID:15998803

  6. ri Tamm: vaid osaledes on võimalik silma vaadata ja mõista oksjoni mõtet / toimetanud Kristi Vahemaa

    Index Scriptorium Estoniae

    Tamm, Jüri, 1937-

    2011-01-01

    Oksjoni idee autor ja korraldaja Jüri Tamm 4.12.2011 toimuvast 12. heategevuslikust kunstioksjonist, mille tulud lähevad hukkunud sportlaste laste toetuseks. Tänavune väliskülaline on kõrgushüppaja Dick Fosbury. Müügile tulevate taieste nimekiri. Tagasivaade oksjonitele. Koostööd tehakse galeriiga Rios

  7. A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane.

    Science.gov (United States)

    Burgers, Pepijn P; Ma, Yuliang; Margarucci, Luigi; Mackey, Mason; van der Heyden, Marcel A G; Ellisman, Mark; Scholten, Arjen; Taylor, Susan S; Heck, Albert J R

    2012-12-21

    Protein kinase A-anchoring proteins (AKAPs) provide spatio-temporal specificity for the omnipotent cAMP-dependent protein kinase (PKA) via high affinity interactions with PKA regulatory subunits (PKA-RI, RII). Many PKA-RII-AKAP complexes are heavily tethered to cellular substructures, whereas PKA-RI-AKAP complexes have remained largely undiscovered. Here, using a cAMP affinity-based chemical proteomics strategy in human heart and platelets, we uncovered a novel, ubiquitously expressed AKAP, termed small membrane (sm)AKAP due to its specific localization at the plasma membrane via potential myristoylation/palmitoylation anchors. In vitro binding studies revealed specificity of smAKAP for PKA-RI (K(d) = 7 nM) over PKA-RII (K(d) = 53 nM) subunits, co-expression of smAKAP with the four PKA R subunits revealed an even more exclusive specificity of smAKAP for PKA-RIα/β in the cellular context. Applying the singlet oxygen-generating electron microscopy probe miniSOG indicated that smAKAP is tethered to the plasma membrane and is particularly dense at cell-cell junctions and within filopodia. Our preliminary functional characterization of smAKAP provides evidence that, like PKA-RII, PKA-RI can be tightly tethered by a novel repertoire of AKAPs, providing a new perspective on spatio-temporal control of cAMP signaling.

  8. Kõltsu mõisa peahoone = Kõltsu manor house / Jüri Irik, Kaire Kemp-Tišler ; intervjueerinud Margit Mutso

    Index Scriptorium Estoniae

    Irik, Jüri, 1961-

    2011-01-01

    Kõltsu mõisa peahoone restaureerimisest. Arhitekt Jüri Irik (AB Ehala & Irik). Sisearhitektid Kaire Kemp-Tišler, Ea Andla (SAB ArtAku). Maastikuarhitektid Ülle Grišakov, Triin Järve. Vitraažide autor Valev Sein. Sepiste autor Heigo Jelle

  9. Mycelium development and architecture, and spore production of Scutellospora reticulata in monoxenic culture with Ri T-DNA transformed carrot roots

    NARCIS (Netherlands)

    De Souza, F.A.; Declerck, S.

    2003-01-01

    Mycelium development and architecture and spore production were studied in Scutellospora reticulata from single-spore isolates grown with Ri T-DNA transformed carrot root-organ culture in monoxenic system. Culture establishment, anastomosis occurrence and auxiliary cell development also were

  10. Muusikamaailm : Rostropovitsh Berliini müüri juures. Philadelphia Curtis Institute ئ 75. Lahti Linnaorkester Jaapanis ja USAs. Domingo taas Washingtonis / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    1999-01-01

    Berliini müüri langemise 10. aastapäevale pühendatud kontserdist 9. nov. Berliinis. Ameerika muusikakõrgkoolist Philadelphia Curtis Institute. Lahti Linnaorkestri kontserdireisist Jaapanisse ja USAsse. P. Domingo on sügishooajal esinenud erinevates Ameerika ooperiteatrites

  11. Ääremärkusi diagnoosiks: imagosfäär tulgu II = Remarks for diagnosis: imagosphere come II / Jüri Soopep

    Index Scriptorium Estoniae

    Soolep, Jüri, 1962-

    2010-01-01

    Vaadeldakse kahte juhtumit, mis lubavad detailselt analüüsida imagosfääri ülesehitamise katset. Tõnismäe monumendist (kavandi autor Arnold Alas, skulptuuri modelleeris Enn Roos aastal 1947) Tallinnas ja Venemaa filmist "Ночной Дозор" (Pervõi Kanal, 2004)

  12. Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells

    DEFF Research Database (Denmark)

    Iwaki, Shoko; Spicka, Jiri; Tkaczyk, Christine

    2008-01-01

    The transmembrane adaptor protein (TRAP), NTAL, is phosphorylated in mast cells following FcvarepsilonRI aggregation whereby it cooperates with LAT to induce degranulation. The Kit ligand, stem cell factor (SCF), enhances antigen-induced degranulation and this also appears to be NTAL-dependent. H...

  13. Inhibition of message for FcepsilonRI alpha chain blocks mast cell IL-4 production induced by co-culture with Mycoplasma pneumoniae.

    Science.gov (United States)

    Luo, Danlin; Dai, Yuling; Duffy, Lynn B; Atkinson, T Prescott

    2008-04-01

    We have previously described the activation of RBL-2H3 mast cells for IL-4 production by Mycoplasma pneumoniae but the mechanism remains unclear. M. pneumoniae binds eukaryotic cells primarily through sialoglycoproteins on the target cell surface. This study was undertaken to determine whether the sialated FcepsilonRI alpha chain on RBL cells is important for M. pneumoniae-induced IL-4 production. We found that IgE-mediated IL-4 release by a series of RBL sublines correlated with the release induced by M. pneumoniae. Further, aggregation of FcgammaRII (CD32) in RBL cells using a monoclonal antibody inhibited both IgE-mediated and mycoplasma-induced IL-4 production, providing further evidence for an Fc receptor-mediated mechanism of activation. To examine the role of FcepsilonRI in mycoplasma-induced IL-4 release, we created stably transfected RBL sublines using a vector expressing a short hairpin sequence designed to inhibit message for the FcepsilonRI alpha chain. IgE-induced IL-4 production by the transfected sublines was reduced in similar proportion to the degree of message suppression. M. pneumoniae-induced IL-4 production in the four transfected sublines was completely blocked in contrast to results with the controls or parent RBL cells. We conclude that the heavily glycosylated FcepsilonRI alpha chain is required for activation of mast cells for IL-4 production by M. pneumoniae.

  14. Uudised : Mika Salo ja Leningrad Cowboys filmisid rockvideot. Erkki-Sven Tüüri autorikontsert moodsate klassikute sarjas. Minimalistlik "Katja Kabanova" Amsterdami ooperis

    Index Scriptorium Estoniae

    2000-01-01

    M. Salo ja ans. Leningrad Cowboys salvestasid Helsingis muusikavideot, M. Salo osaleb kitarristina ansambli plaadil "Terzo Mondo". 12. mail andis Absolute Ensemble K. Järvi juhatusel New Yorgis sarja "Heliloojate portreed" raames kontserdi E.-S. Tüüri loomingust. Nederlandse Operas tuli lavale L. Janaceki ekspressiivne ooper "Katja Kabanova", lavastusest

  15. Äriühingu maine kahjustamisest tulenevad hüvitisnõuded : [bakalaureusetöö] / Sirli Pettai ; Tartu Ülikool, õigusteaduskond ; juhendaja: Tambet Tampuu

    Index Scriptorium Estoniae

    Pettai, Sirli, 1986-

    2009-01-01

    Äriühingute mainest ja selle kahjustamisega tekkinud kahjust, lepinguõiguslikest kahjuhüvitisnõuetest, hüvitisnõuetest deliktiõiguses, konkurentsist lepinguõiguse ja deliktiõiguse vahel juriidilise isiku maine kahjustamisest tulenevate hüvitisnõuete puhul

  16. Håkan Berg: jätkusuutmatut äri ei tasu laenuga päästa / Håkan Berg

    Index Scriptorium Estoniae

    Berg, Håkan, 1955-

    2009-01-01

    Swedbanki Eesti, Läti ja Leedu juhi sõnul on Swedbank siin pikemaks ajaks. Tema väitel ei ole pank oma laenamisprotsessi dramaatiliselt muutnud, kuid jätkusuutmatu äri toetamine viib lõpuks suuremate kaotusteni

  17. Role of activatory Fc gamma RI and Fc gamma RIII and inhibitory Fc gamma RII in inflammation and cartilage destruction during experimental antigen-induced arthritis.

    NARCIS (Netherlands)

    Lent, P.L.E.M. van; Nabbe, K.C.A.M.; Blom, A.B.; Holthuysen, A.E.M.; Sloetjes, A.W.; Putte, L.B.A. van de; Verbeek, S.; Berg, W.B. van den

    2001-01-01

    IgG-containing immune complexes, which are found in most RA joints, communicate with hematopoietic cells using three classes of Fc receptors(Fc gamma RI, -II, -III). In a previous study we found that if a chronic T-cell-mediated antigen-induced arthritis (AIA) was elicited in knee joints of FcR

  18. IMPACTUL INTEGRĂRII EUROPENE ASUPRA PIEŢII DE ASIGURĂRI GENERALE DIN ROMANIA

    Directory of Open Access Journals (Sweden)

    Elena Popa

    2008-05-01

    Full Text Available The present article aims to proving that the business concentration is the main tendencywitch is to become manifest in the insurance field, determined by the increasing interest of internationalstrategic investors to penetrate or consolidate their position on the Romanian insurance market. Actually, in thenear future, the specific industry is going to settle, meaning that only the efficient insurance companies aremeant to last through the years, most of them being international companies. The coming of the theseinternational companies will determine a stiff competition and the final result is to be favourable for the client,the one who buys the insurance, improving the quality of services provided.The efforts to develop new insurance products, the interest in diversifying the insurers’ portfoliotowards non-auto categories and consolidating the territorial networks as well as some alternative distributionchannels, constitute measures in Romanian insurance industry maturation.

  19. Network cosmology.

    Science.gov (United States)

    Krioukov, Dmitri; Kitsak, Maksim; Sinkovits, Robert S; Rideout, David; Meyer, David; Boguñá, Marián

    2012-01-01

    Prediction and control of the dynamics of complex networks is a central problem in network science. Structural and dynamical similarities of different real networks suggest that some universal laws might accurately describe the dynamics of these networks, albeit the nature and common origin of such laws remain elusive. Here we show that the causal network representing the large-scale structure of spacetime in our accelerating universe is a power-law graph with strong clustering, similar to many complex networks such as the Internet, social, or biological networks. We prove that this structural similarity is a consequence of the asymptotic equivalence between the large-scale growth dynamics of complex networks and causal networks. This equivalence suggests that unexpectedly similar laws govern the dynamics of complex networks and spacetime in the universe, with implications to network science and cosmology.

  20. Network Cosmology

    Science.gov (United States)

    Krioukov, Dmitri; Kitsak, Maksim; Sinkovits, Robert S.; Rideout, David; Meyer, David; Boguñá, Marián

    2012-01-01

    Prediction and control of the dynamics of complex networks is a central problem in network science. Structural and dynamical similarities of different real networks suggest that some universal laws might accurately describe the dynamics of these networks, albeit the nature and common origin of such laws remain elusive. Here we show that the causal network representing the large-scale structure of spacetime in our accelerating universe is a power-law graph with strong clustering, similar to many complex networks such as the Internet, social, or biological networks. We prove that this structural similarity is a consequence of the asymptotic equivalence between the large-scale growth dynamics of complex networks and causal networks. This equivalence suggests that unexpectedly similar laws govern the dynamics of complex networks and spacetime in the universe, with implications to network science and cosmology. PMID:23162688

  1. Single Nucleotide Polymorphisms of the High Affinity IgG Receptor FcγRI Reduce Immune Complex Binding and Downstream Effector Functions.

    Science.gov (United States)

    Brandsma, Arianne M; Ten Broeke, Toine; van Dueren den Hollander, Evelien; Caniels, Thomas G; Kardol-Hoefnagel, Tineke; Kuball, Jürgen; Leusen, Jeanette H W

    2017-10-01

    Binding of IgG Abs to FcγRs on immune cells induces FcγR cross-linking that leads to cellular effector functions, such as phagocytosis, Ab-dependent cellular cytotoxicity, and cytokine release. However, polymorphisms in low affinity FcγRs have been associated with altered avidity toward IgG, thereby substantially impacting clinical outcomes of multimodular therapy when targeting cancer or autoimmune diseases with mAbs as well as the frequency and severity of autoimmune diseases. In this context, we investigated the consequences of three nonsynonymous single nucleotide polymorphisms (SNPs) for the high affinity receptor for IgG, FcγRI. Only SNP V39I, located in the extracellular domain of FcγRI, reduces immune-complex binding of FcγRI whereas monomeric IgG binding is unaffected. This leads to reduced FcγRI effector functions, including Fc receptor γ-chain signaling and intracellular calcium mobilization. SNPs I301M and I338T, located in the transmembrane or intracellular domain, respectively, have no influence on monomeric IgG or immune complex binding, but FcRγ signaling is decreased for both SNPs, especially for I338T. We also found that the frequency of these SNPs in a cohort of healthy Dutch individuals is very low within the population. To our knowledge, this study addresses for the first time the biological consequences of SNPs in the high affinity FcγR, and reveals reduction in several FcγRI functions, which have the potential to alter efficacy of therapeutic Abs. Copyright © 2017 by The American Association of Immunologists, Inc.

  2. Exaggerated neointima formation in human C-reactive protein transgenic mice is IgG Fc receptor type I (Fc gamma RI)-dependent.

    Science.gov (United States)

    Xing, Dongqi; Hage, Fadi G; Chen, Yiu-Fai; McCrory, Mark A; Feng, Wenguang; Skibinski, Gregory A; Majid-Hassan, Erum; Oparil, Suzanne; Szalai, Alexander J

    2008-01-01

    Neointima formation after vascular injury is exaggerated in ovariectomized (OVX) human C-reactive protein transgenic mice (CRPtg) compared to nontransgenic mice (NTG). We tested the hypothesis that this CRP-mediated exacerbation requires IgG Fc receptors (Fc gamma Rs). OVX NTG, CRPtg, and CRPtg lacking Fc gamma RI, Fc gamma RIIb, Fc gamma RIII, or the common gamma chain (FcR gamma) had their common carotid artery ligated. Twenty-eight days later neointimal thickening in CRPtg/Fc gamma RI(-/-) and CRPtg/FcR gamma (-/-) was significantly less than in CRPtg and no worse than in NTG, whereas in CRPtg/Fc gamma RIIb(-/-) and CRPtg/Fc gamma RIII(-/-) neointimal thickness was equal to or greater than in CRPtg. Immunohistochemistry revealed human CRP in the neointima of CRPtg, but little or none was observed in those lacking Fc gamma RI or FcR gamma. Real-time reverse transcriptase-polymerase chain reaction demonstrated that Fc gamma R types I to III were expressed in the CRPtg arteries, with Fc gamma RI expression increasing by threefold after ligation injury. Levels of serum complement (C3), neointimal deposition of complement (C3d), and cellular composition (monocytes, macrophages, lymphocytes) in the neointima did not differ among the different CRPtg genotypes. However, by immunofluorescence a neointimal population of F4/80+CRP+ cells was revealed only in OVX CRPtg. The exaggerated response to vascular injury provoked by CRP in OVX CRPtg depends on Fc gamma RI and probably requires its expression by F4/80+ cells.

  3. The bacteriophage WORiC is the active phage element in wRi of Drosophila simulans and represents a conserved class of WO phages

    Directory of Open Access Journals (Sweden)

    Biliske Jennifer A

    2011-11-01

    Full Text Available Abstract Background The alphaproteobacterium Wolbachia pipientis, the most common endosymbiont in eukaryotes, is found predominantly in insects including many Drosophila species. Although Wolbachia is primarily vertically transmitted, analysis of its genome provides evidence for frequent horizontal transfer, extensive recombination and numerous mobile genetic elements. The genome sequence of Wolbachia in Drosophila simulans Riverside (wRi is available along with the integrated bacteriophages, enabling a detailed examination of phage genes and the role of these genes in the biology of Wolbachia and its host organisms. Wolbachia is widely known for its ability to modify the reproductive patterns of insects. One particular modification, cytoplasmic incompatibility, has previously been shown to be dependent on Wolbachia density and inversely related to the titer of lytic phage. The wRi genome has four phage regions, two WORiBs, one WORiA and one WORiC. Results In this study specific primers were designed to distinguish between these four prophage types in wRi, and quantitative PCR was used to measure the titer of bacteriophages in testes, ovaries, embryos and adult flies. In all tissues tested, WORiA and WORiB were not found to be present in excess of their integrated prophages; WORiC, however, was found to be present extrachromosomally. WORiC is undergoing extrachromosomal replication in wRi. The density of phage particles was found to be consistent in individual larvae in a laboratory population. The WORiC genome is organized in conserved blocks of genes and aligns most closely with other known lytic WO phages, WOVitA and WOCauB. Conclusions The results presented here suggest that WORiC is the lytic form of WO in D. simulans, is undergoing extrachromosomal replication in wRi, and belongs to a conserved family of phages in Wolbachia.

  4. Telecommunication networks

    CERN Document Server

    Iannone, Eugenio

    2011-01-01

    Many argue that telecommunications network infrastructure is the most impressive and important technology ever developed. Analyzing the telecom market's constantly evolving trends, research directions, infrastructure, and vital needs, Telecommunication Networks responds with revolutionized engineering strategies to optimize network construction. Omnipresent in society, telecom networks integrate a wide range of technologies. These include quantum field theory for the study of optical amplifiers, software architectures for network control, abstract algebra required to design error correction co

  5. A Cross-Layer Routing Design for Multi-Interface Wireless Mesh Networks

    Directory of Open Access Journals (Sweden)

    Tzu-Chieh Tsai

    2009-01-01

    Full Text Available In recent years, Wireless Mesh Networks (WMNs technologies have received significant attentions. WMNs not only accede to the advantages of ad hoc networks but also provide hierarchical multi-interface architecture. Transmission power control and routing path selections are critical issues in the past researches of multihop networks. Variable transmission power levels lead to different network connectivity and interference. Further, routing path selections among different radio interfaces will also produce different intra-/interflow interference. These features tightly affect the network performance. Most of the related works on the routing protocol design do not consider transmission power control and multi-interface environment simultaneously. In this paper, we proposed a cross-layer routing protocol called M2iRi2 which coordinates transmission power control and intra-/interflow interference considerations as routing metrics. Each radio interface calculates the potential tolerable-added transmission interference in the physical layer. When the route discovery starts, the M2iRi2 will adopt the appropriate power level to evaluate each interface quality along paths. The simulation results demonstrate that our design can enhance both network throughput and end-to-end delay.

  6. Interconnected networks

    CERN Document Server

    2016-01-01

    This volume provides an introduction to and overview of the emerging field of interconnected networks which include multi layer or multiplex networks, as well as networks of networks. Such networks present structural and dynamical features quite different from those observed in isolated networks. The presence of links between different networks or layers of a network typically alters the way such interconnected networks behave – understanding the role of interconnecting links is therefore a crucial step towards a more accurate description of real-world systems. While examples of such dissimilar properties are becoming more abundant – for example regarding diffusion, robustness and competition – the root of such differences remains to be elucidated. Each chapter in this topical collection is self-contained and can be read on its own, thus making it also suitable as reference for experienced researchers wishing to focus on a particular topic.

  7. Network maintenance

    CERN Multimedia

    IT Department

    2009-01-01

    A site wide network maintenance has been scheduled for Saturday 28 February. Most of the network devices of the General Purpose network will be upgraded to a newer software version, in order to improve our network monitoring capabilities. This will result in a series of short (2-5 minutes) random interruptions everywhere on the CERN sites along this day. This upgrade will not affect: the Computer centre itself, building 613, the Technical Network and the LHC experiments dedicated networks at the pits. Should you need more details on this intervention, please contact Netops by phone 74927 or email mailto:Netops@cern.ch. IT/CS Group

  8. Network maintenance

    CERN Multimedia

    GS Department

    2009-01-01

    A site-wide network maintenance operation has been scheduled for Saturday 28 February. Most of the network devices of the general purpose network will be upgraded to a newer software version, in order to improve our network monitoring capabilities. This will result in a series of short (2-5 minutes) random interruptions everywhere on the CERN sites throughout the day. This upgrade will not affect the Computer Centre itself, Building 613, the Technical Network and the LHC experiments, dedicated networks at the pits. For further details of this intervention, please contact Netops by phone 74927 or e-mail mailto:Netops@cern.ch. IT/CS Group

  9. Network Ambivalence

    Directory of Open Access Journals (Sweden)

    Patrick Jagoda

    2015-08-01

    Full Text Available The language of networks now describes everything from the Internet to the economy to terrorist organizations. In distinction to a common view of networks as a universal, originary, or necessary form that promises to explain everything from neural structures to online traffic, this essay emphasizes the contingency of the network imaginary. Network form, in its role as our current cultural dominant, makes scarcely imaginable the possibility of an alternative or an outside uninflected by networks. If so many things and relationships are figured as networks, however, then what is not a network? If a network points towards particular logics and qualities of relation in our historical present, what others might we envision in the future? In  many ways, these questions are unanswerable from within the contemporary moment. Instead of seeking an avant-garde approach (to move beyond networks or opting out of networks (in some cases, to recover elements of pre-networked existence, this essay proposes a third orientation: one of ambivalence that operates as a mode of extreme presence. I propose the concept of "network aesthetics," which can be tracked across artistic media and cultural forms, as a model, style, and pedagogy for approaching interconnection in the twenty-first century. The following essay is excerpted from Network Ambivalence (Forthcoming from University of Chicago Press. 

  10. Cigarette Smoke Suppresses the Surface Expression of c-kit and FcεRI on Mast Cells

    Directory of Open Access Journals (Sweden)

    M. E. Givi

    2013-01-01

    Full Text Available Chronic obstructive pulmonary disease (COPD is a multicomponent disease characterized by emphysema and/or chronic bronchitis. COPD is mostly associated with cigarette smoking. Cigarette smoke contains over 4,700 chemical compounds, including free radicals and LPS (a Toll-Like Receptor 4 agonist at concentrations which may contribute to the pathogenesis of diseases like COPD. We have previously shown that short-term exposure to cigarette smoke medium (CSM can stimulate several inflammatory cells via TLR4 and that CSM reduces the degranulation of bone-marrow-derived mast cells (BMMCs. In the current study, the effect of CSM on mast cells maturation and function was investigated. Coculturing of BMMC with CSM during the development of bone marrow progenitor cells suppressed the granularity and the surface expression of c-kit and FcεRI receptors. Stimulation with IgE/antigen resulted in decreased degranulation and release of Th1 and Th2 cytokines. The effects of CSM exposure could not be mimicked by the addition of LPS to the culture medium. In conclusion, this study shows that CSM may affect mast cell development and subsequent response to allergic activation in a TLR4-independent manner.

  11. Effects of catastrophic draining of Wisconsinian glacial lakes on the continental shelf; an example from Block Island Sound, RI

    Science.gov (United States)

    Klotsko, S.; Driscoll, N. W.

    2013-12-01

    After the last glacial maximum (~21 kya) runoff from the Laurentide ice sheet was trapped behind terminal moraines, creating large glacial lakes along the New York-southern New England coast. These lakes drained catastrophically from east to west, with Lake Block Island Sound (occupying current Block Island Sound, RI; BIS) draining ~ 16 kya. Glacial Lake Connecticut, located in current Long Island Sound just south of BIS, drained through Block Island Sound approximately 500 years later. This catastrophic draining created large, 100-meter deep depressions on the shelf as waters flowed through a low in the moraine called ';The Race'. These depressions have remained open through the transgression, with exposure to swift modern tidal currents in the region. In 1999, the two easternmost, more circular features were mapped using high-resolution seismic CHIRP data. These data show several geologic units, including bedrock, glacial lake varved deposits, and modern sediment. The modern sediment can be seen prograding towards the eastern depression, but is hindered by a local topographic high, preventing the depression from being filled. We postulate that the depressions were not filled in with sediment during the transgression because they were filled with ice and are now drowned kettle holes. Another possibility is the transgression across the shelf was too rapid for sediment to fill in such large depressions.

  12. Modeling tools for an Integrated River-Delta-Sea system investigation: the Pan-European Research Infrastructure DANUBIUS-RI philosophy

    Science.gov (United States)

    Umgiesser, Georg; Bellafiore, Debora; De Pascalis, Francesca; Icke, Joost; Stanica, Adrian

    2017-04-01

    The DANUBIUS Research Infrastructure (DANUBIUS-RI) is a new initiative to address the challenges and opportunities of research on large river- sea (RS) systems. DANUBIUS-RI is a distributed pan-European RI that will provide a platform for interdisciplinary research. It will deal with RS investigation through facilities and expertise from a large number of European institutions becoming a 'one-stop shop' for knowledge exchange in managing RS systems, ranging from freshwater to marine research. Globally, RS systems are complex and dynamic, with huge environmental, social and economic value. They are poorly understood but under increasing pressure through pollution, hydraulic engineering, water supply, energy, flood control and erosion. RS systems in Europe are among the most impacted globally, after centuries of industrialisation, urbanisation and agricultural intensification. Improved understanding is essential to avoid irreversible degradation and for restoration. DANUBIUS-RI will provide, among a number of other facilities concerning observations, analyses, impacts' evaluation, a modeling node that will provide integrated up-to-date tools, at locations of high scientific importance and opportunity, covering the RS systems - from source (upper parts of rivers - mountain lakes) to the transition with coastal seas. Modeling will be one of the major services provided by DANUBIUS-RI, relying on the inputs from the whole RI. RS systems are challenging from a modelling point of view, because of the complex morphology and the wide temporal and spatial range of processes occurring. Scale interaction plays a central role, considering the different hydro-eco-morphological processes on the large (basin) and small (local, coast, rivers, lagoons) scale. Currently, different model applications are made for the different geographical domains, and also for subsets of the processes. For instance there are separate models for rainfall runoff in the catchment, a sewer model for the

  13. Chemical composition of the essential oil from Corsican Mentha aquatica--combined analysis by GC(RI), GC-MS and 13C NMR spectroscopy.

    Science.gov (United States)

    Sutour, Sylvain; Tomi, Félix; Bradesi, Pascale; Casanova, Joseph

    2011-10-01

    The essential oil (EO) of M. aquatica L. growing wild in Corsica was isolated by dry vapor distillation and submitted to combined analysis by column chromatography over silica gel, GC(RI), GC-MS and 13C NMR spectroscopy. The composition was dominated byoxygenated monoterpenes and characterized by the occurrence of menthofuran (50.7%) as the major component. In parallel, seven laboratory-distilled oil samples isolated from individual plants collected in Corsica were analyzed by GC(RI) and 13C NMR spectroscopy. Onlyquantitative differences were observed between the samples. Beside the usual terpenes, various p-menthane lactones (mintlactone, isomintlactone, hydroxymintlactone, menthofurolactone and epimenthofurolactone) have been identified in all the oil samples.

  14. Kronik pelvik ağrı ve siklik hematüri ile başvuran bir kadında mesanede endometriozis

    OpenAIRE

    Balcı, Serdar; Ertuğrul, Çağlan; Yörükoğlu, Kutsal; Tuna, Burçin; Koyuncuoğlu, Meral; Okyay, Recep Emre; Doğan, Ömer Erbil; Aslan, Güven

    2017-01-01

    Otuz altı yaşında, gebelik 2 doğum 1 abortus 1 ve 7yıl önce sezeryan öyküsü bulunan hasta siklik hematüri (menüri) ve kronikpelvik ağrı yakınması ile başvurdu. Abdominopelvik ultrasonografide mesanedekitle şüphesiyle sistoskopi yapılarak biopsi alındı. Patolojik tanı mesanedeendometriozis idi. Gonadotropin releasing hormon analoğu yakınması (leuprolideasetat) tedavisi 6 ay uygulandı. Tedaviden 2 ay sonra kasık ağrısı şikayeti iletekrar başvurdu. Tanısal laparoskopi ve ikinci bakış sistoskopis...

  15. Improving Clinical Outcome in the Nutritional Management of Sarcopenia at the National Center for Geriatric Health and Research Institute (NCGH-RI), Philippines.

    Science.gov (United States)

    Ramos, Miguel A

    2015-01-01

    Background: One of the National Center for Geriatric Health-Research Institute (NCGH-RI) mission is to be the leader in innovative health care approaches to improve the quality of life of the Senior Citizens in the country, and one of its strategies to attain its mission is to look into at how it can promote clinical outcomes in conditions that are prevalent in this population. One such condition that has been identified is "Sarcopenia" which up to this point has been the subject of intensive research both in basic and clinical levels. However, it is still not part of the daily routine clinical experience of medical providers both in the ambulatory or out-patient and acute or in-patient encounter. To achieve this, the NCHG-RI has included it in the screening for geriatric syndromes using the Comprehensive Geriatric Assessment (CGA).

  16. Small-scale hydro-power plant in Quinto - Preliminary project; Progetto minicentrale idroelettrica, Ri Secco - Quinto. Programma piccole centrali idrauliche. Progetto di massima

    Energy Technology Data Exchange (ETDEWEB)

    Dotti, R. [Reali e Guscetti SA, Ambri (Switzerland); Rosselli, P. [Celio Engineering SA, Ambri (Switzerland)

    2009-06-15

    This report for the Swiss Federal Office of Energy (SFOE) takes a look at a project for the realisation of a small hydro-power plant on the alpine stream 'Ri Secco' in the municipality of Quinto, southern Switzerland. The Ri Secco partly flows in a steep canyon. The elevation difference of 810 or 620 m (depending on the location of the water deviation from the stream) is favorable to the installation of a small-scale high-head power plant. The report presents details on the hydrological data and the dimensioning of the installation. Several variants are considered, which also include two possible penstock diameters for each weir location. The electricity production expected is discussed, as is the economic viability of the project.

  17. Network neuroscience.

    Science.gov (United States)

    Bassett, Danielle S; Sporns, Olaf

    2017-02-23

    Despite substantial recent progress, our understanding of the principles and mechanisms underlying complex brain function and cognition remains incomplete. Network neuroscience proposes to tackle these enduring challenges. Approaching brain structure and function from an explicitly integrative perspective, network neuroscience pursues new ways to map, record, analyze and model the elements and interactions of neurobiological systems. Two parallel trends drive the approach: the availability of new empirical tools to create comprehensive maps and record dynamic patterns among molecules, neurons, brain areas and social systems; and the theoretical framework and computational tools of modern network science. The convergence of empirical and computational advances opens new frontiers of scientific inquiry, including network dynamics, manipulation and control of brain networks, and integration of network processes across spatiotemporal domains. We review emerging trends in network neuroscience and attempt to chart a path toward a better understanding of the brain as a multiscale networked system.

  18. Organizational Networks

    DEFF Research Database (Denmark)

    Grande, Bård; Sørensen, Ole Henning

    1998-01-01

    The paper focuses on the concept of organizational networks. Four different uses of the concept of organizational network are identified and critically discussed. Special focus is placed on how information and communication technologies as communication mediators and cognitive pictures influence...

  19. Network workshop

    DEFF Research Database (Denmark)

    Bruun, Jesper; Evans, Robert Harry

    2014-01-01

    This paper describes the background for, realisation of and author reflections on a network workshop held at ESERA2013. As a new research area in science education, networks offer a unique opportunity to visualise and find patterns and relationships in complicated social or academic network data...... research community. With this workshop, participants were offered a way into network science based on authentic educational research data. The workshop was constructed as an inquiry lesson with emphasis on user autonomy. Learning activities had participants choose to work with one of two cases of networks...... network methodology in one’s research might supersede the perceived benefits of doing so. As a response to that problem, we argue that workshops can act as a road towards meaningful engagement with networks and highlight that network methodology promises new ways of interpreting data to answer questions...

  20. International Network of Passive Correlation Ranging for Orbit Determination of a Geostationary Satellite

    Science.gov (United States)

    Kaliuzhnyi, Mykola; Bushuev, Felix; Shulga, Oleksandr; Sybiryakova, Yevgeniya; Shakun, Leonid; Bezrukovs, Vladislavs; Moskalenko, Sergiy; Kulishenko, Vladislav; Malynovskyi, Yevgen

    2016-12-01

    An international network of passive correlation ranging of a geostationary telecommunication satellite is considered in the article. The network is developed by the RI "MAO". The network consists of five spatially separated stations of synchronized reception of DVB-S signals of digital satellite TV. The stations are located in Ukraine and Latvia. The time difference of arrival (TDOA) on the network stations of the DVB-S signals, radiated by the satellite, is a measured parameter. The results of TDOA estimation obtained by the network in May-August 2016 are presented in the article. Orbital parameters of the tracked satellite are determined using measured values of the TDOA and two models of satellite motion: the analytical model SGP4/SDP4 and the model of numerical integration of the equations of satellite motion. Both models are realized using the free low-level space dynamics library OREKIT (ORbit Extrapolation KIT).