WorldWideScience

Sample records for net balance expressed

  1. Positive muscle protein net balance and differential regulation of atrogene expression after resistance exercise and milk protein supplementation

    DEFF Research Database (Denmark)

    Reitelseder, Søren; Agergaard, Jakob; Doessing, Simon

    2014-01-01

    body mass), or a non-caloric control after heavy resistance exercise on protein turnover and mRNA expressions of forkhead homeobox type O (FOXO) isoforms, muscle RING finger 1 (MuRF1), and Atrogin1 in young healthy males. Methods Protein turnover was determined by stable isotope-labeled leucine...... and femoral arteriovenous blood samples at rest and during 6-h recovery. Muscle biopsies were collected at −60 min (rest) and at 60, 210, and 360 min in the recovery period. Results During recovery, leucine NB was significantly higher in the protein groups compared to control (P

  2. Net Balanced Floorplanning Based on Elastic Energy Model

    DEFF Research Database (Denmark)

    Liu, Wei; Nannarelli, Alberto

    2008-01-01

    with balanced net delays to increase the safety margins of the design. In this paper, we investigate the properties of floorplanning based on the elastic energy model. The B*-tree, which is based on an ordered binary tree, is used for circuit representation and the elastic energy is used as the cost function...

  3. 47 CFR 69.608 - Carrier Common Line hypothetical net balance.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Carrier Common Line hypothetical net balance... SERVICES (CONTINUED) ACCESS CHARGES Exchange Carrier Association § 69.608 Carrier Common Line hypothetical net balance. The hypothetical net balance shall be equal to a Carrier Common Line revenue requirement...

  4. 47 CFR 69.609 - End User Common Line hypothetical net balances.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false End User Common Line hypothetical net balances... SERVICES (CONTINUED) ACCESS CHARGES Exchange Carrier Association § 69.609 End User Common Line hypothetical net balances. (a) If the company does not participate in the association tariff for such element, the...

  5. Energy balance framework for Net Zero Energy buildings

    Science.gov (United States)

    Approaching a Net Zero Energy (NZE) building goal based on current definitions is flawed for two principal reasons - they only deal with energy quantities required for operations, and they do not establish a threshold, which ensures that buildings are optimized for reduced consum...

  6. Estimates of Regional Equilibrium Line Altitudes and Net Mass Balance from MODIS Imagery

    Science.gov (United States)

    Shea, J. M.; Menounos, B.; Moore, R. D.

    2011-12-01

    Glacier mass balance is a key variable used to assess the health of glaciers and ice sheets. Estimates of glacier mass balance are required to model the dynamic response of glaciers and ice sheets to climate change, estimate sea-level contribution from surface melt, and document the response of glaciers to climate forcing. Annually resolved estimates of regional mass balance for mountain ranges is often inferred from a sparse network of ground-based measurements of mass balance for individual glaciers. Given that net mass balance is highly correlated with the annual equilibrium line altitude (ELA), we develop an automated approach to estimate the ELA, and by inference net mass balance, on large glaciers and icefields using MODIS 250 m imagery (MOD02QKM). We discriminate areas of bare ice and snow/firn using the product of MODIS' red (0.620 - 0.670 μ m) and near infrared (0.841 - 0.876 μ m) bands. To assess the skill in estimating glacier ELAs, we compare ELAs derived from (1) manual delineation and (2) unsupervised classification of the band product to ground-based observations of ELA and net mass balance at seven long term mass-balance monitoring sites in western North America (Gulkana, Wolverine, Lemon Creek, Taku, Place, Peyto, and South Cascade). Spatial and temporal variations in MODIS-derived ELAs provide an opportunity to validate regional mass-balance models, estimate surface melt contributions to sea-level rise, and examine the cryospheric response to climate change.

  7. Partitioning the net ecosystem carbon balance of a semiarid steppe into biological and geological components

    NARCIS (Netherlands)

    Rey, A.; Belelli Marchesini, L.; Etiope, G.; Papale, D.; Canfora, E.; Valentini, R.; Pegoraro, E.

    2014-01-01

    Recent studies have highlighted the need to consider geological carbon sources when estimating the net ecosystem carbon balance (NECB) of terrestrial ecosystems located in areas potentially affected by geofluid circulation. We propose a new methodology using physical parameters of the atmospheric

  8. Dissolved carbon leaching from soil is a crucial component of the net ecosystem carbon balance

    NARCIS (Netherlands)

    Kindler, R.; Siemens, J.; Kaiser, K.; Moors, E.J.

    2011-01-01

    Estimates of carbon leaching losses from different land use systems are few and their contribution to the net ecosystem carbon balance is uncertain. We investigated leaching of dissolved organic carbon (DOC), dissolved inorganic carbon (DIC), and dissolved methane (CH4), at forests, grasslands, and

  9. Historic simulation of net ecosystem carbon balance for the Great Dismal Swamp

    Science.gov (United States)

    Sleeter, Rachel

    2017-01-01

    Estimating ecosystem carbon (C) balance relative to natural disturbances and land management strengthens our understanding of the benefits and tradeoffs of carbon sequestration. We conducted a historic model simulation of net ecosystem C balance in the Great Dismal Swamp, VA. for the 30-year time period of 1985-2015. The historic simulation of annual carbon flux was calculated with the Land Use and Carbon Scenario Simulator (LUCAS) model. The LUCAS model utilizes a state-and-transition simulation model coupled with a carbon stock-flow accounting model to estimate net ecosystem C balance, and long term sequestration rates under various ecological conditions and management strategies. The historic model simulation uses age-structured forest growth curves for four forest species, C stock and flow rates for 8 pools and 14 fluxes, and known data for disturbance and management. The annualized results of C biomass are provided in this data release in the following categories: Growth, Heterotrophic Respiration (Rh), Net Ecosystem Production (NEP), Net Biome Production (NBP), Below-ground Biomass (BGB) Stock, Above-ground Biomass (AGB) Stock, AGB Carbon Loss from Fire, BGB Carbon Loss from Fire, Deadwood Carbon Loss from Management, and Total Carbon Loss. The table also includes the area (annually) of each forest type in hectares: Atlantic white cedar Area (hectares); Cypress-gum Area (hectares); Maple-gum Area (hectares); Pond pine Area (hectares). Net ecosystem production for the Great Dismal Swamp (~ 54,000 ha), from 1985 to 2015 was estimated to be a net sink of 0.97 Tg C. When the hurricane and six historic fire events were modeled, the Great Dismal Swamp became a net source of 0.89 Tg C. The cumulative above and belowground C loss estimated from the South One in 2008 and Lateral West fire in 2011 totaled 1.70 Tg C, while management activities removed an additional 0.01 Tg C. The C loss in below-ground biomass alone totaled 1.38 Tg C, with the balance (0.31 Tg C

  10. Energy balance of maize production in Brazil: the energetic constraints of a net positive outcome

    Energy Technology Data Exchange (ETDEWEB)

    Soares, Luis Henrique de Barros; Alves, Bruno Jose Rodrigues; Urquiaga, Segundo

    2008-07-01

    Among the factors used to analyze and to establish the sustainability of a whole agricultural production system, the energy balance is one of the most powerful and robust. The maize production in Brazil is surely the reflex of an energy intensive system that demands many field operations and heavy fertilizer applications, notably nitrogen in urea form. This work presents an energy balance of this major crop adjusted to the Brazilian conditions of cultivation. The input components were grouped based on their energy contents, and the possible improvements in the agricultural practices that could improve energy balance and net energy withdrawn from the farming were considered. The replacement of N synthetic fertilizer by biological nitrogen fixation, whether the process is directly carried out by endophytic diazotroph bacteria or by means of a N{sub 2}- fixing legume culture planted before the main crop as a green-manure is also discussed. (author)

  11. Dissolved carbon leaching from soil is a crucial component of the net ecosystem carbon balance

    DEFF Research Database (Denmark)

    Kindler, Reimo; Siemens, Jan; Kaiser, Klaus

    2011-01-01

    Estimates of carbon leaching losses from different land use systems are few and their contribution to the net ecosystem carbon balance is uncertain. We investigated leaching of dissolved organic carbon (DOC), dissolved inorganic carbon (DIC), and dissolved methane (CH4), at forests, grasslands......, and croplands across Europe. Biogenic contributions to DIC were estimated by means of its d13C signature. Leaching of biogenic DIC was 8.34.9 gm2 yr1 for forests, 24.17.2 gm2 yr1 for grasslands, and 14.64.8 gm2 yr1 for croplands. DOC leaching equalled 3.51.3 gm2 yr1 for forests, 5.32.0 gm2 yr1 for grasslands...... ecosystem exchange (NEE) plus carbon inputs with fertilization minus carbon removal with harvest. Carbon leaching increased the net losses from cropland soils by 24–105% (median: 25%). For the majority of forest sites, leaching hardly affected actual net ecosystem carbon balances because of the small...

  12. Net technical assessment

    OpenAIRE

    Wegmann, David G.

    1989-01-01

    Approved for public release; distribution is unlimited. The present and near term military balance of power between the U.S. and the Soviet Union can be expressed in a variety of net assessments. One can examine the strategic nuclear balance, the conventional balance in Europe, the maritime balance, and many others. Such assessments are essential not only for policy making but for arms control purposes and future force structure planning. However, to project the future military balance, on...

  13. Impact of the diet on net endogenous acid production and acid-base balance.

    Science.gov (United States)

    Poupin, Nathalie; Calvez, Juliane; Lassale, Camille; Chesneau, Caroline; Tomé, Daniel

    2012-06-01

    Net acid production, which is composed of volatile acids (15,000 mEq/day) and metabolic acids (70-100 mEq/day) is relatively small compared to whole-body H⁺ turnover (150,000 mEq/day). Metabolic acids are ingested from the diet or produced as intermediary or end products of endogenous metabolism. The three commonly reported sources of net acid production are the metabolism of sulphur amino acids, the metabolism or ingestion of organic acids, and the metabolism of phosphate esters or dietary phosphoproteins. Net base production occurs mainly as a result of absorption of organic anions from the diet. To maintain acid-base balance, ingested and endogenously produced acids are neutralized within the body by buffer systems or eliminated from the body through the respiratory (excretion of volatile acid in the form of CO₂) and urinary (excretion of fixed acids and remaining H⁺) pathways. Because of the many reactions involved in the acid-base balance, the direct determination of acid production is complex and is usually estimated through direct or indirect measurements of acid excretion. However, indirect approaches, which assess the acid-forming potential of the ingested diet based on its composition, do not take all the acid-producing reactions into account. Direct measurements therefore seem more reliable. Nevertheless, acid excretion does not truly provide information on the way acidity is dealt with in the plasma and this measurement should be interpreted with caution when assessing acid-base imbalance. Copyright © 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

  14. Multi-year net ecosystem carbon balance at a horticulture-extracted restored peatland

    Science.gov (United States)

    Nugent, Kelly; Strachan, Ian; Strack, Maria

    2017-04-01

    small source of CO2, NEE in the Typha plots showed significantly greater CO2 uptake capacity relative to any other restored plant community. High productivity combined with reduced CH4 flux suggests that Typha may be playing a key role in reducing the overall impact of the remnant ditches on the net ecosystem carbon balance. A preliminary footprint analysis suggests that ecosystem-level CH4 flux is being primarily driven by release from hotspots while the majority of the tower source area is a very small source of methane.

  15. 16 CFR 500.7 - Net quantity of contents, method of expression.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Net quantity of contents, method of expression. 500.7 Section 500.7 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENT... expression. The net quantity of contents shall be expressed in terms of weight or mass, measure, numerical...

  16. Comparative analysis of net energy balance for satellite power systems (SPS) and other energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Cirillo, R.R.; Cho, B.S.; Monarch, M.R.; Levine, E.P.

    1980-04-01

    The net energy balance of seven electric energy systems is assessed: two coal-based, one nuclear, two terrestrial solar, and two solar power satellites, with principal emphasis on the latter two systems. Solar energy systems require much less operating energy per unit of electrical output. However, on the basis of the analysis used here, coal and nuclear systems are two to five times more efficient at extracting useful energy from the primary resource base than are the solar energy systems. The payback period for all systems is less than 1.5 years, except for the terrestrial photovoltaic (19.8 yr) and the solar power satellite system (6.4 yr), both of which rely on energy-intensive silicon cells.

  17. Simulated Net Ecosystem Carbon Balance of Western US Forests Under Contemporary Climate and Management

    Science.gov (United States)

    Yang, Z.; Law, B. E.; Jones, M. O.

    2015-12-01

    Previous projections of the contemporary forest carbon balance in the western US showed uncertainties associated with impacts of climate extremes and a coarse spatio-temporal resolution implemented over heterogeneous mountain regions. We modified the Community Land Model (CLM) 4.5 to produce 4km resolution forest carbon changes with drought, fire and management in the western US. We parameterized the model with species data using local plant trait observations for 30 species. To quantify uncertainty, we evaluated the model with data from flux sites, inventories and ancillary data in the region. Simulated GPP was lower than the measurements at our AmeriFlux sites by 17-22%. Simulated burned area was generally higher than Landsat observations, suggesting the model overestimates fire emissions with the new fire model. Landsat MTBS data show high severity fire represents only a small portion of the total burnt area (12-14%), and no increasing trend from 1984 to 2011. Moderate severity fire increased ~0.23%/year due to fires in the Sierra Nevada (Law & Waring 2014). Oregon, California, and Washington were a net carbon sink, and net ecosystem carbon balance (NECB) declined in California over the past 15 years, partly due to drought impacts. Fire emissions were a small portion of the regional carbon budget compared with the effect of harvest removals. Fossil fuel emissions in CA are more than 3x that of OR and WA combined, but are lower per capita. We also identified forest regions that are most vulnerable to climate-driven transformations and to evaluate the effects of management strategies on forest NECB. Differences in forest NECB among states are strongly influenced by the extent of drought (drier longer in the SW) and management intensity (higher in the PNW).

  18. Improvement potential for net energy balance of biodiesel derived from palm oil: A case study from Indonesian practice

    Energy Technology Data Exchange (ETDEWEB)

    Kamahara, Hirotsugu [Research Institute of Science for Safety and Sustainability, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305-8569 (Japan); Hasanudin, Udin [Department of Agroindustrial Technology, University of Lampung, Bandar Lampung, Lampung 35145 (Indonesia); Widiyanto, Anugerah [International Cooperation Center for Engineering Education Development, Toyohashi University of Technology, Toyohashi, Aichi 441-8580 (Japan); Tachibana, Ryuichi [Department of Civil and Environmental Engineering, Nagaoka University of Technology, Nagaoka, Niigata 940-2188 (Japan); Atsuta, Yoichi; Goto, Naohiro; Daimon, Hiroyuki [Department of Environmental and Life Sciences, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku, Toyohashi, Aichi 441-8580 (Japan); Fujie, Koichi [Graduate School of Environment and Information Sciences, Yokohama National University, Yokohama, Kanagawa 240-8501 (Japan)

    2010-12-15

    Biodiesel derived from palm oil has been recognized as a high-productivity oil crop among the first generation of biofuels. This study evaluated and discussed the net energy balance for biodiesel in Indonesia by calculating the net energy ratio (NER) and net energy production (NEP) form the total energy input and output. The results of the calculation of energy input for the default scenario demonstrated that the primary energy inputs in the biodiesel production lifecycle were the methanol feedstock, energy input during the biodiesel production process, and urea production. These three items amounted to 85% of the total energy input. Next, we considered and evaluated ways to potentially improve the energy balance by utilizing by-products and biogas from wastewater treatment in the palm oil mill. This result emphasized the importance of utilizing the biomass residue and by-products. Finally, we discussed the need to be aware of energy balance issues between countries when biofuels are transported internationally. (author)

  19. Net ecosystem exchange of CO2 and carbon balance for eight temperate organic soils under agricultural management

    DEFF Research Database (Denmark)

    Elsgaard, Lars; Görres, C.-M.; Hoffmann, Carl Christian

    2012-01-01

    This study presents the first annual estimates of net ecosystem exchange (NEE) of CO2 and net ecosystem carbon balances (NECB) of contrasting Danish agricultural peatlands. Studies were done at eight sites representing permanent grasslands (PG) and rotational (RT) arable soils cropped to barley......) sites, NEE (mean ± standard error, SE) was 5.1 ± 0.9 and 8.6 ± 2.0 Mg C ha−1 yr−1, respectively, but with the overall lowest value observed for potato cropping (3.5 Mg C ha−1 yr−1). This was partly attributed to a short-duration vegetation period and drying of the soil especially in potato ridges. NECB...... and temperate climate zones. It was stressed that evaluation of emission factors should explicitly differentiate between data representing net C balance from a soil perspective and CO2-C balance from an atmospheric perspective. Modelling of inter-annual variability in NEE for three selected sites during a 21...

  20. Controls on declining carbon balance with leaf age among 10 woody species in Australian woodland: do leaves have zero daily net carbon balances when they die?

    Science.gov (United States)

    Reich, Peter B; Falster, Daniel S; Ellsworth, David S; Wright, Ian J; Westoby, Mark; Oleksyn, Jacek; Lee, Tali D

    2009-01-01

    * Here, we evaluated how increased shading and declining net photosynthetic capacity regulate the decline in net carbon balance with increasing leaf age for 10 Australian woodland species. We also asked whether leaves at the age of their mean life-span have carbon balances that are positive, zero or negative. * The net carbon balances of 2307 leaves on 53 branches of the 10 species were estimated. We assessed three-dimensional architecture, canopy openness, photosynthetic light response functions and dark respiration rate across leaf age sequences on all branches. We used YPLANT to estimate light interception and to model carbon balance along the leaf age sequences. * As leaf age increased to the mean life-span, increasing shading and declining photosynthetic capacity each separately reduced daytime carbon gain by approximately 39% on average across species. Together, they reduced daytime carbon gain by 64% on average across species. * At the age of their mean life-span, almost all leaves had positive daytime carbon balances. These per leaf carbon surpluses were of a similar magnitude to the estimated whole-plant respiratory costs per leaf. Thus, the results suggest that a whole-plant economic framework, including respiratory costs, may be useful in assessing controls on leaf longevity.

  1. 16 CFR 500.23 - Expression of net quantity of contents in SI Metric units.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Expression of net quantity of contents in SI... REGULATIONS UNDER SECTION 4 OF THE FAIR PACKAGING AND LABELING ACT § 500.23 Expression of net quantity of... not capitalized. Periods should not be used after the symbol. Symbols are always written in the...

  2. Posters: balancing overkill and freedom of expression

    CERN Multimedia

    CERN Internal Communication and HR Department

    2014-01-01

    The number of posters put up at CERN to inform, engage and invite is growing quickly, and they are taking over an ever-increasing number of walls, doors, pillars and glass panels. In the interests of freedom of information, no official restrictions are in place, but we are nonetheless obliged to maintain a fair balance. Here we discuss this issue.   Posters clamour for our attention, becoming more and more invasive and often eternal as they are never taken down... While the need to inform and to be informed is a legitimate one, we also have to respect our workplace. It’s no surprise that walls or pillars (sometimes freshly painted) at junctions in corridors that are busy at peak times are seen as ideal targets by people who want to publicise their events or activities, but this abundance, or overabundance, of posters is sometimes seen as vandalism of communal areas. What's more, the posters themselves are sometimes vandalised: comments, sometimes offensive, may be added and the...

  3. Effects of Permafrost Thaw on Net Ecosystem Carbon Balance in a Subarctic Peatland

    Science.gov (United States)

    Wang, Z.; Roulet, N. T.; Moore, T. R.

    2014-12-01

    This research is to assess changes in net ecosystem carbon balance (NECB) with permafrost thaw in northern peatland: in particular how changes in C biogeochemistry influence NECB. Thawed transects associated with varying stages of permafrost thaw: from palsas with intact permafrost (P), through edge of palsa (EP), dry lawn (DL), wet lawn (WL), edge of thawed pond (ET), pond sedges (PS), to several thawed ponds (TP) in a subarctic peatland in northern Quebec were sampled in the snow free seasons of 2013 and 2014. The exchange of CO2 and CH4, vegetation, dissolved organic C (DOC) concentration and biodegradability, active layer depth, air and peat temperatures, water table depth (WT), pH, and conductivity were measured. Peat temperatures were quite similar among different locations, but the WT decreased significantly along the transect creating varied environmental conditions that supporting different plant communities. From dry to wet area, vegetation abundance and biomass showed reductions of shrubs and lichens, and increases of Sphagnum, grasses and sedges. Pore water pH increased from dry to wet area, and conductivity slightly decreased. Wet thaw area WL, ET and PS had relatively higher season gross ecosystem production (GEP) and higher season ecosystem respiration (ER), but relative similar net ecosystem CO2 exchange (NEE). Only TP had a significant higher positive season NEE. Palsa was the only CH4 sink, and quite high CH4 emissions were found after it thawed. CH4-C release significantly increased from dry to wet in thawed area, which even several times bigger than total C exchange in ET and PS. Generally, wet area had higher DOC concentration and higher DOC biodegradability indicated by lower SUVA254 (except PS which received great influence from pond). All components in the NECB (GEP, ER, CH4, DOC) increased significantly in magnitude from palsa to wet thawed area, and ecosystem C sink turned into source as palsa thawed into PS and TP. These results

  4. Modeling and Performance Evaluation of Internet of Things based on Petri Nets and Behavior Expression

    OpenAIRE

    Lin Chen; Linxiang Shi; Wen'an Tan

    2012-01-01

    Modeling and performance evaluation plays an important role on the theoretical research and technology improvement of the Internet of Things (IoT). In the study, the modeling and performance evaluation method based on Petri Nets and behavior expression is presented. Firstly, according to the system information flow chart, the constraint relationship between places and transitions are identified and then graphic Extended Stochastic Petri Nets model is built up; next, the behavior expression me...

  5. Dcf1 regulates neuropeptide expression and maintains energy balance.

    Science.gov (United States)

    Liu, Qiang; Chen, Yu; Li, Qian; Wu, Liang; Wen, Tieqiao

    2017-05-22

    Neuropeptide Y (NPY) is an important neurotransmitter in the brain that plays a pivotal role in food intake and energy storage. Although many studies have focused on these functions, the regulation of NPY expression remains unclear. Here we showed that dendritic cell factor 1 (Dcf1) regulates NPY expression and maintains energy balance. We found that NPY expression is significantly reduced in the hypothalamus of Dcf1 knockout (Dcf1-/-, KO) mice. In contrast, Dcf1 overexpression significantly increases NPY expression in the cell line. We also found that Dcf1 acts upstream of the NPY gene to regulate NPY expression and modulates the NPY-NPY receptor 1-GABA signal. Notably, we observed a significant increase in the ATP concentration in Dcf1-/- mice, suggesting a greater demand for energy in the absence of Dcf1. We studied the relationship between Dcf1 and NPY and revealed that Dcf1 plays a critical role in energy balance. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Energy balance of the global photovoltaic (PV) industry--is the PV industry a net electricity producer?

    Science.gov (United States)

    Dale, Michael; Benson, Sally M

    2013-04-02

    A combination of declining costs and policy measures motivated by greenhouse gas (GHG) emissions reduction and energy security have driven rapid growth in the global installed capacity of solar photovoltaics (PV). This paper develops a number of unique data sets, namely the following: calculation of distribution of global capacity factor for PV deployment; meta-analysis of energy consumption in PV system manufacture and deployment; and documentation of reduction in energetic costs of PV system production. These data are used as input into a new net energy analysis of the global PV industry, as opposed to device level analysis. In addition, the paper introduces a new concept: a model tracking energetic costs of manufacturing and installing PV systems, including balance of system (BOS) components. The model is used to forecast electrical energy requirements to scale up the PV industry and determine the electricity balance of the global PV industry to 2020. Results suggest that the industry was a net consumer of electricity as recently as 2010. However, there is a >50% that in 2012 the PV industry is a net electricity provider and will "pay back" the electrical energy required for its early growth before 2020. Further reducing energetic costs of PV deployment will enable more rapid growth of the PV industry. There is also great potential to increase the capacity factor of PV deployment. These conclusions have a number of implications for R&D and deployment, including the following: monitoring of the energy embodied within PV systems; designing more efficient and durable systems; and deploying PV systems in locations that will achieve high capacity factors.

  7. Net radiation, sensible and latent heat flux densities on slopes computed by the energy balance method

    Science.gov (United States)

    Fritschen, Leo; Qian, Ping

    1990-01-01

    Energy balance components obtained over five grass-covered sloping surfaces near Manhattan, KS, using the Bowen ratio energy balance technique with the instruments mounted horizontally were compared with calculated values when the instruments were mounted parallel to the surfaces. Hourly values of the components changed when the instruments were parallel to the surfaces. The changes were larger at low solar angles (spring and fall) and on steeper slopes. An area average of daylight totals, assuming that all aspects were equally represented, changed only 0.1 percent on June 6 and 2.3 percent on October 11. The calculations, extended to steeper slopes, indicated small changes in the daylight totals for slopes of less than 10 deg.

  8. Salt Marsh Net Ecosystem Carbon Balance: Improving Methods to Quantify the Role of Lateral (Tidal) Exchanges

    Science.gov (United States)

    Kroeger, K. D.

    2016-02-01

    Coastal wetlands are prime candidates for greenhouse gas emission offsets as they display extraordinarily high rates of carbon (C) sequestration. However, lack of data about rates of and controls on C sequestration in tidal wetlands, as well as substantial temporal and spatial heterogeneity, complicate development of both models and a methodology for use by C registries. The goals of our field research are to improve understanding of the climatic role of coastal wetlands, quantify potential for GHG emission offsets through restoration or preservation, and quantify impacts of eutrophication and other environmental factors. Among our objectives is to construct C and greenhouse gas (GHG) budgets for salt marshes, based on measurements of GHG exchanges with the atmosphere, C storage in soils, and lateral (tidal) exchanges of gases, C, and sediment. In this presentation, emphasis is on rate and source of tidal exchanges between salt marshes and adjacent estuaries. We measured fluxes by collecting high frequency data on tidal water flows and physical and chemical conditions in wetland channels using acoustic and optical sensors, as well as laser absorption spectrometry. To provide site-specific calibrations of sensors, we collected water samples across tidal cycles and seasons. Source investigations include analysis of stable isotope and lipid compositions. We used multiple regressions to estimate dissolved organic (DOC) and inorganic carbon (DIC) concentrations at high frequency over extended time. Carbon flux was calculated as the product of concentration and water flux, corrected for modeled flow outside of the tidal creek. Annual rates of net C flux from wetland to estuary indicate that both DOC and DIC are large terms in the salt marsh carbon budget relative to net exchange with the atmosphere and rate of storage in soil, and that DIC flux may have been underestimated in previous studies.

  9. Changes in the net carbon balance following a shelterwood harvest at Howland Forest in central Maine seven years after harvest

    Science.gov (United States)

    Scott, N. A.; Hollinger, D.; Davidson, E. A.; Rodrigues, C.; Hughes, H.; Lee, J. T.; Richardson, A. D.; Dail, B.

    2009-12-01

    a net C sink in 2005 and has remained a net C sink since that time. In 2007, the combination of C storage in live biomass and wood products put the net C balance at about 0.8 Mg C ha-1y-1. Our results demonstrate that rates of tree growth recovered rapidly after the harvest, returning the system to a net C sink within about four years after harvest. Further research will investigate the mechanisms behind the rapidly increasing tree growth rates after the harvest.

  10. Quantity of dietary protein intake, but not pattern of intake, affects net protein balance primarily through differences in protein synthesis in older adults.

    Science.gov (United States)

    Kim, Il-Young; Schutzler, Scott; Schrader, Amy; Spencer, Horace; Kortebein, Patrick; Deutz, Nicolaas E P; Wolfe, Robert R; Ferrando, Arny A

    2015-01-01

    To examine whole body protein turnover and muscle protein fractional synthesis rate (MPS) following ingestions of protein in mixed meals at two doses of protein and two intake patterns, 20 healthy older adult subjects (52-75 yr) participated in one of four groups in a randomized clinical trial: a level of protein intake of 0.8 g (1RDA) or 1.5 g·kg(-1)·day(-1) (∼2RDA) with uneven (U: 15/20/65%) or even distribution (E: 33/33/33%) patterns of intake for breakfast, lunch, and dinner over the day (1RDA-U, 1RDA-E, 2RDA-U, or 2RDA-E). Subjects were studied with primed continuous infusions of L-[(2)H5]phenylalanine and L-[(2)H2]tyrosine on day 4 following 3 days of diet habituation. Whole body protein kinetics [protein synthesis (PS), breakdown, and net balance (NB)] were expressed as changes from the fasted to the fed states. Positive NB was achieved at both protein levels, but NB was greater in 2RDA vs. 1RDA (94.8 ± 6.0 vs. 58.9 ± 4.9 g protein/750 min; P = 0.0001), without effects of distribution on NB. The greater NB was due to the higher PS with 2RDA vs. 1RDA (15.4 ± 4.8 vs. -18.0 ± 8.4 g protein/750 min; P = 0.0018). Consistent with PS, MPS was greater with 2RDA vs. 1RDA, regardless of distribution patterns. In conclusion, whole body net protein balance was greater with protein intake above recommended dietary allowance (0.8 g protein·kg(-1)·day(-1)) in the context of mixed meals, without demonstrated effects of protein intake pattern, primarily through higher rates of protein synthesis at whole body and muscle levels. Copyright © 2015 the American Physiological Society.

  11. Asymmetric warming significantly affects net primary production, but not ecosystem carbon balances of forest and grassland ecosystems in northern China.

    Science.gov (United States)

    Su, Hongxin; Feng, Jinchao; Axmacher, Jan C; Sang, Weiguo

    2015-03-13

    We combine the process-based ecosystem model (Biome-BGC) with climate change-scenarios based on both RegCM3 model outputs and historic observed trends to quantify differential effects of symmetric and asymmetric warming on ecosystem net primary productivity (NPP), heterotrophic respiration (Rh) and net ecosystem productivity (NEP) of six ecosystem types representing different climatic zones of northern China. Analysis of covariance shows that NPP is significant greater at most ecosystems under the various environmental change scenarios once temperature asymmetries are taken into consideration. However, these differences do not lead to significant differences in NEP, which indicates that asymmetry in climate change does not result in significant alterations of the overall carbon balance in the dominating forest or grassland ecosystems. Overall, NPP, Rh and NEP are regulated by highly interrelated effects of increases in temperature and atmospheric CO2 concentrations and precipitation changes, while the magnitude of these effects strongly varies across the six sites. Further studies underpinned by suitable experiments are nonetheless required to further improve the performance of ecosystem models and confirm the validity of these model predictions. This is crucial for a sound understanding of the mechanisms controlling the variability in asymmetric warming effects on ecosystem structure and functioning.

  12. Using the balanced scorecard to characterize benefits of integration in the safety net.

    Science.gov (United States)

    Wells, Rebecca; Weiner, Bryan

    2005-05-01

    The purpose of this study was to develop a comprehensive framework depicting the potential benefits of integration among health-care providers that serve vulnerable populations. Research teams interviewed participants in 12 integrated functions across seven community health-centre-led networks. Functions included clinical processes; managed care contracting; and administrative services such as human resources, finance, and information systems. Using a Balanced Scorecard framework, benefits were identified across financial, customer, internal business, and learning and growth perspectives. Financial benefits were more frequently cited relative to managed care and administrative functions than relative to clinical functions. Clinical functions were frequently characterized by perceived improvements in patient care quality, while managed-care functions appeared to yield most benefits in access. Administrative functions were most often associated with improvements in internal business operations. There were substantial findings in learning and growth across all three types of integration, in keeping with the early stages of the integrated functions in the study. Findings imply that integration among health-care providers yields a wide range of benefits, but not necessarily quickly or financial in nature.

  13. Convolutional neural networks with balanced batches for facial expressions recognition

    Science.gov (United States)

    Battini Sönmez, Elena; Cangelosi, Angelo

    2017-03-01

    This paper considers the issue of fully automatic emotion classification on 2D faces. In spite of the great effort done in recent years, traditional machine learning approaches based on hand-crafted feature extraction followed by the classification stage failed to develop a real-time automatic facial expression recognition system. The proposed architecture uses Convolutional Neural Networks (CNN), which are built as a collection of interconnected processing elements to simulate the brain of human beings. The basic idea of CNNs is to learn a hierarchical representation of the input data, which results in a better classification performance. In this work we present a block-based CNN algorithm, which uses noise, as data augmentation technique, and builds batches with a balanced number of samples per class. The proposed architecture is a very simple yet powerful CNN, which can yield state-of-the-art accuracy on the very competitive benchmark algorithm of the Extended Cohn Kanade database.

  14. Multi-Ethnicity in the Malaysian Workplace: The Net Balance of 35 Years of Affirmative Policies as Observed by a Foreign Visitor

    Science.gov (United States)

    Montesino, Max U.

    2007-01-01

    This paper looks at the net societal balance of post-independence affirmative action policies in Malaysia. Social imbalances prompted the country to implement affirmative policies to uplift the majority natives (Malays, Indigenous people of Sabah and Sarawak, etc.). These policies were reluctantly accepted by the immigrant communities (Chinese,…

  15. Quantifying the role of fire in the Earth system - Part 2: Impact on the net carbon balance of global terrestrial ecosystems for the 20th century

    Energy Technology Data Exchange (ETDEWEB)

    Li, Fang; Bond-Lamberty, Benjamin; Levis, Samuel

    2014-03-07

    Fire is the primary terrestrial ecosystem disturbance agent on a global scale. It affects carbon balance of global terrestrial ecosystems by emitting carbon to atmosphere directly and immediately from biomass burning (i.e., fire direct effect), and by changing net ecosystem productivity and land-use carbon loss in post-fire regions due to biomass burning and fire-induced vegetation mortality (i.e., fire indirect effect). Here, we provide the first quantitative assessment about the impact of fire on the net carbon balance of global terrestrial ecosystems for the 20th century, and investigate the roles of fire direct and indirect effects. This study is done by quantifying the difference between the 20th century fire-on and fire-off simulations with NCAR community land model CLM4.5 as the model platform. Results show that fire decreases net carbon gain of the global terrestrial ecosystems by 1.0 Pg C yr-1 average across the 20th century, as a results of fire direct effect (1.9 Pg C yr-1) partly offset by indirect effect (-0.9 Pg C yr-1). Fire generally decreases the average carbon gains of terrestrial ecosystems in post-fire regions, which are significant over tropical savannas and part of forests in North America and the east of Asia. The general decrease of carbon gains in post-fire regions is because fire direct and indirect effects have similar spatial patterns and the former (to decrease carbon gain) is generally stronger. Moreover, the effect of fire on net carbon balance significantly declines prior to ~1970 with trend of 8 Tg C yr-1 due to increasing fire indirect effect and increases afterward with trend of 18 Tg C yr-1 due to increasing fire direct effect.

  16. Net expression inhibits the growth of pancreatic ductal adenocarcinoma cell PL45 in vitro and in vivo.

    Directory of Open Access Journals (Sweden)

    Baiwen Li

    Full Text Available Pancreatic ductal adenocarcinoma has a poor prognosis due to late diagnosis and a lack of effective therapeutic options. Thus, it is important to better understand its molecular mechanisms and to develop more effective treatments for the disease. The ternary complex factor Net, which exerts its strong inhibitory function on transcription of proto-oncogene gene c-fos by forming ternary complexes with a second transcription factor, has been suspected of being involved in pancreatic cancer and other tumors biology. In this study, we found that the majority of pancreatic ductal adenocarcinoma tissues and cell lines had weak or no expression of Net, whereas significantly high level of Net expression occurred in paired adjacent normal tissues we studied. Furthermore, using in vitro and in vivo model systems, we found that overexpression of Net inhibited cell growth and survival and induced cell apoptosis in human pancreatic ductal adenocarcinoma cell PL45; the mechanisms by which Net inhibited the cell cycle progression were mainly through P21-Cyclin D1/CDK4 Pathway. Our data thus suggested that Net might play an important role in pancreatic carcinogenesis, possibly by acting as a tumor suppressor gene.

  17. Gene expression prediction by soft integration and the elastic net-best performance of the DREAM3 gene expression challenge.

    Directory of Open Access Journals (Sweden)

    Mika Gustafsson

    Full Text Available BACKGROUND: To predict gene expressions is an important endeavour within computational systems biology. It can both be a way to explore how drugs affect the system, as well as providing a framework for finding which genes are interrelated in a certain process. A practical problem, however, is how to assess and discriminate among the various algorithms which have been developed for this purpose. Therefore, the DREAM project invited the year 2008 to a challenge for predicting gene expression values, and here we present the algorithm with best performance. METHODOLOGY/PRINCIPAL FINDINGS: We develop an algorithm by exploring various regression schemes with different model selection procedures. It turns out that the most effective scheme is based on least squares, with a penalty term of a recently developed form called the "elastic net". Key components in the algorithm are the integration of expression data from other experimental conditions than those presented for the challenge and the utilization of transcription factor binding data for guiding the inference process towards known interactions. Of importance is also a cross-validation procedure where each form of external data is used only to the extent it increases the expected performance. CONCLUSIONS/SIGNIFICANCE: Our algorithm proves both the possibility to extract information from large-scale expression data concerning prediction of gene levels, as well as the benefits of integrating different data sources for improving the inference. We believe the former is an important message to those still hesitating on the possibilities for computational approaches, while the latter is part of an important way forward for the future development of the field of computational systems biology.

  18. Cellular MYCro economics: Balancing MYC function with MYC expression.

    Science.gov (United States)

    Levens, David

    2013-11-01

    The expression levels of the MYC oncoprotein have long been recognized to be associated with the outputs of major cellular processes including proliferation, cell growth, apoptosis, differentiation, and metabolism. Therefore, to understand how MYC operates, it is important to define quantitatively the relationship between MYC input and expression output for its targets as well as the higher-order relationships between the expression levels of subnetwork components and the flow of information and materials through those networks. Two different views of MYC are considered, first as a molecular microeconomic manager orchestrating specific positive and negative responses at individual promoters in collaboration with other transcription and chromatin components, and second, as a macroeconomic czar imposing an overarching rule onto all active genes. In either case, c-myc promoter output requires multiple inputs and exploits diverse mechanisms to tune expression to the appropriate levels relative to the thresholds of expression that separate health and disease.

  19. NIRExpNet: Three-Stream 3D Convolutional Neural Network for Near Infrared Facial Expression Recognition

    Directory of Open Access Journals (Sweden)

    Zhan Wu

    2017-11-01

    Full Text Available Facial expression recognition (FER under active near-infrared (NIR illumination has the advantages of illumination invariance. In this paper, we propose a three-stream 3D convolutional neural network, named as NIRExpNet for NIR FER. The 3D structure of NIRExpNet makes it possible to extract automatically, not just spatial features, but also, temporal features. The design of multiple streams of the NIRExpNet enables it to fuse local and global facial expression features. To avoid over-fitting, the NIRExpNet has a moderate size to suit the Oulu-CASIA NIR facial expression database that is a medium-size database. Experimental results show that the proposed NIRExpNet outperforms some previous state-of-art methods, such as Histogram of Oriented Gradient to 3D (HOG 3D, Local binary patterns from three orthogonal planes (LBP-TOP, deep temporal appearance-geometry network (DTAGN, and adapt 3D Convolutional Neural Networks (3D CNN DAP.

  20. Relationships between net primary productivity and stand age for several forest types and their influence on China's carbon balance.

    Science.gov (United States)

    Wang, Shaoqiang; Zhou, Lei; Chen, Jingming; Ju, Weimin; Feng, Xianfeng; Wu, Weixing

    2011-06-01

    Affected by natural and anthropogenic disturbances such as forest fires, insect-induced mortality and harvesting, forest stand age plays an important role in determining the distribution of carbon pools and fluxes in a variety of forest ecosystems. An improved understanding of the relationship between net primary productivity (NPP) and stand age (i.e., age-related increase and decline in forest productivity) is essential for the simulation and prediction of the global carbon cycle at annual, decadal, centurial, or even longer temporal scales. In this paper, we developed functions describing the relationship between national mean NPP and stand age using stand age information derived from forest inventory data and NPP simulated by the BEPS (Boreal Ecosystem Productivity Simulator) model in 2001. Due to differences in ecobiophysical characteristics of different forest types, NPP-age equations were developed for five typical forest ecosystems in China (deciduous needleleaf forest (DNF), evergreen needleleaf forest in tropic and subtropical zones (ENF-S), deciduous broadleaf forest (DBF), evergreen broadleaf forest (EBF), and mixed broadleaf forest (MBF)). For DNF, ENF-S, EBF, and MBF, changes in NPP with age were well fitted with a common non-linear function, with R(2) values equal to 0.90, 0.75, 0.66, and 0.67, respectively. In contrast, a second order polynomial was best suitable for simulating the change of NPP for DBF, with an R(2) value of 0.79. The timing and magnitude of the maximum NPP varied with forest types. DNF, EBF, and MBF reached the peak NPP at the age of 54, 40, and 32 years, respectively, while the NPP of ENF-S maximizes at the age of 13 years. The highest NPP of DBF appeared at 122 years. NPP was generally lower in older stands with the exception of DBF, and this particular finding runs counter to the paradigm of age-related decline in forest growth. Evaluation based on measurements of NPP and stand age at the plot-level demonstrates the reliability

  1. Balancing

    Science.gov (United States)

    Harteveld, Casper

    At many occasions we are asked to achieve a “balance” in our lives: when it comes, for example, to work and food. Balancing is crucial in game design as well as many have pointed out. In games with a meaningful purpose, however, balancing is remarkably different. It involves the balancing of three different worlds, the worlds of Reality, Meaning, and Play. From the experience of designing Levee Patroller, I observed that different types of tensions can come into existence that require balancing. It is possible to conceive of within-worlds dilemmas, between-worlds dilemmas, and trilemmas. The first, the within-world dilemmas, only take place within one of the worlds. We can think, for example, of a user interface problem which just relates to the world of Play. The second, the between-worlds dilemmas, have to do with a tension in which two worlds are predominantly involved. Choosing between a cartoon or a realistic style concerns, for instance, a tension between Reality and Play. Finally, the trilemmas are those in which all three worlds play an important role. For each of the types of tensions, I will give in this level a concrete example from the development of Levee Patroller. Although these examples come from just one game, I think the examples can be exemplary for other game development projects as they may represent stereotypical tensions. Therefore, to achieve harmony in any of these forthcoming games, it is worthwhile to study the struggles we had to deal with.

  2. Energy balance-dependent regulation of ovine glucose 6-phosphate dehydrogenase protein isoform expression.

    Science.gov (United States)

    Triantaphyllopoulos, Kostas A; Laliotis, George P; Bizelis, Iosif A

    2014-01-01

    G6PDH is the rate-limiting enzyme of the pentose phosphate pathway and one of the principal source of NADPH, a major cellular reductant. Importantly, in ruminant's metabolism the aforementioned NADPH provided, is utilized for de novo fatty acid synthesis. Previous work of cloning the ovine (Ovis aries) og6pdh gene has revealed the presence of two cDNA transcripts (og6pda and og6pdb), og6pdb being a product of alternative splicing not similar to any other previously reported.(1) In the current study the effect of energy balance in the ovine G6PDH protein expression was investigated, shedding light on the biochemical features and potential physiological role of the oG6PDB isoform. Changes in energy balance leads to protein expression changes in both transcripts, to the opposite direction and not in a proportional way. Negative energy balance was not in favor of the presence of any particular isoform, while both protein expression levels were not significantly different (P > 0.05). In contrast, at the transition point from negative to positive and on the positive energy balance, there is a significant increase of oG6PDA compared with oG6PDB protein expression (P < 0.001). Both oG6PDH protein isoforms changed significantly toward the positive energy balance. oG6PDA is escalating, while oG6PDB is falling, under the same stimulus (positive energy balance alteration). This change is also positively associated with increasing levels in enzyme activity, 4 weeks post-weaning in ewes' adipose tissue. Furthermore, regression analysis clearly demonstrated the linear correlation of both proteins in response to the WPW, while energy balance, enzyme activity, and oG6PDA relative protein expression follow the same escalating trend; in contrast, oG6PDB relative protein expression falls in time, similar to both transcripts accumulation pattern, as reported previously.(2.)

  3. Effect of drink carbohydrate content on postexercise gastric emptying, rehydration, and the calculation of net fluid balance.

    Science.gov (United States)

    Clayton, David J; Evans, Gethin H; James, Lewis J

    2014-02-01

    The purpose of this study was to examine the gastric emptying and rehydration effects of hypotonic and hypertonic glucose-electrolyte drinks after exercise-induced dehydration. Eight healthy males lost ~1.8% body mass by intermittent cycling and rehydrated (150% of body mass loss) with a hypotonic 2% (2% trial) or a hypertonic 10% (10% trial) glucose-electrolyte drink over 60 min. Blood and urine samples were taken at preexercise, postexercise, and 60, 120, 180, and 240 min postexercise. Gastric and test drink volume were determined 15, 30, 45, 60, 90, and 120 min postexercise. At the end of the gastric sampling period 0.3% (2% trial) and 42.1% (10% trial; p fluid balance was greater from 120 min during the 10% trial (p fluid balance was corrected for the volume of fluid in the stomach, it was greater at 60 and 120 min during the 2% trial (p fluid balance.

  4. Net soil respiration and greenhouse gas balance along a sequence of forest disturbance to smallholder rubber and oil palm plantations in Sumatra

    Science.gov (United States)

    Khusyu Aini, Fitri; Hergoualc'h, Kristell; Smith, Jo; Verchot, Louis; Martius, Christopher

    2017-04-01

    The rapid increase in demand for land to establish oil palm and rubber plantations has led to the conversion of forests, with potential impacts on greenhouse gas emissions and on climate change. This study evaluates the net greenhouse gas balance following forest change to other land uses, i.e. one year rubber plantation, twenty-year rubber plantation and eight year oil palm plantation on Sumatran mineral soils. None of the plantations had ever been fertilized previously. During this study they were fertilized to provide nitrogen at the recommended rate used by farmers (33.3 kg N ha-1 y-1). The ecosystem stores carbon in litterfall, standing litter biomass (undergrowth vegetation, leaves, twigs, litter on the soil surface), soil organic matter, root biomass, and standing tree biomass. It releases carbon to the atmosphere through soil respiration fluxes, negative values indicating that carbon is stored by the land use change and positive values indicating emissions to the atmosphere. Net soil respiration was assessed using a mass balance approach: standing litter and tree biomass were measured once; the rate of carbon accumulation from standing litter and tree biomass was calculated by dividing the stock by the age of plantation or the time since logging started in the disturbed forest. The carbon accumulation in standing litter, tree biomass in the forest and soil organic matter for all land-uses was estimated from available in the literature. Root biomass for each land-use system was calculated using the root:shoot ratio. The net soil respiration of carbon dioxide from the forest, disturbed forest, one year rubber plantation, twenty-year rubber plantation and oil palm plantation were calculated to be -6 (± 5), 12 (± 6), 11 (± 15), 10 (± 5), 39 (± 7) Mg ha-1 y-1, respectively. Soil nitrous oxide, methane and litterfall were measured for 14 months and respiration fluxes were measured for 5 months across land uses and different seasons. The measured emissions of

  5. Evaluating algorithms for the Generation of Referring Expressions using a balanced corpus

    NARCIS (Netherlands)

    Gatt, A.; van der Sluis, Ielka; van Deemter, Kees

    2007-01-01

    Despite being the focus of intensive research, evaluation of algorithms that generate referring expressions is still in its infancy. We describe a corpusbased evaluation methodology, applied to a number of classic algorithms in this area. The methodology focuses on balance and semantic transparency

  6. Immediate and delayed effects of gill-net capture on acid-base balance and intramuscular lactate concentration of gummy sharks, Mustelus antarcticus.

    Science.gov (United States)

    Frick, Lorenz H; Walker, Terence I; Reina, Richard D

    2012-06-01

    Many sharks are captured as untargeted by-catch during commercial fishing operations and are subsequently discarded. A reliable assessment of the proportion of discarded sharks that die post-release as a result of excessive physiological stress is important for fisheries management and conservation purposes, but a reliable physiological predictor of post-release mortality has not been identified. To investigate effects of gill-net capture on the acid-base balance of sharks, we exposed gummy sharks, Mustelus antarcticus, to 60 min of gill-net capture in a controlled setting, and obtained multiple blood and muscle tissue samples during a 72-h recovery period following the capture event. Overall mortality of gummy sharks was low (9%). Blood pH was significantly depressed immediately after the capture event due to a combination of respiratory and metabolic acidosis. Maximum concentrations of plasma lactate (9.9 ± 1.5 mmol L(-1)) were measured 3h after the capture event. Maximum intramuscular lactate concentrations (37.0 ± 4.6 μmol g(-1)) were measured immediately after the capture event, and intramuscular lactate concentrations were substantially higher than plasma lactate concentrations at all times. Sharks in poor condition had low blood pH and high intramuscular lactate concentration, but blood pH does not appear to be a reliable predictor of survival. Suitability of intramuscular lactate concentration as predictor of delayed mortality deserves further investigation. Copyright © 2011 Elsevier Inc. All rights reserved.

  7. Serotonin receptor expression in human prefrontal cortex: balancing excitation and inhibition across postnatal development.

    Directory of Open Access Journals (Sweden)

    Evelyn K Lambe

    Full Text Available Serotonin and its receptors (HTRs play critical roles in brain development and in the regulation of cognition, mood, and anxiety. HTRs are highly expressed in human prefrontal cortex and exert control over prefrontal excitability. The serotonin system is a key treatment target for several psychiatric disorders; however, the effectiveness of these drugs varies according to age. Despite strong evidence for developmental changes in prefrontal Htrs of rodents, the developmental regulation of HTR expression in human prefrontal cortex has not been examined. Using postmortem human prefrontal brain tissue from across postnatal life, we investigated the expression of key serotonin receptors with distinct inhibitory (HTR1A, HTR5A and excitatory (HTR2A, HTR2C, HTR4, HTR6 effects on cortical neurons, including two receptors which appear to be expressed to a greater degree in inhibitory interneurons of cerebral cortex (HTR2C, HTR6. We found distinct developmental patterns of expression for each of these six HTRs, with profound changes in expression occurring early in postnatal development and also into adulthood. However, a collective look at these HTRs in terms of their likely neurophysiological effects and major cellular localization leads to a model that suggests developmental changes in expression of these individual HTRs may not perturb an overall balance between inhibitory and excitatory effects. Examining and understanding the healthy balance is critical to appreciate how abnormal expression of an individual HTR may create a window of vulnerability for the emergence of psychiatric illness.

  8. Phytoplankton growth balanced by clam and zooplankton grazing and net transport into the low-salinity zone of the San Francisco Estuary

    Science.gov (United States)

    Kimmerer, Wim J.; Thompson, Janet K.

    2014-01-01

    We estimated the influence of planktonic and benthic grazing on phytoplankton in the strongly tidal, river-dominated northern San Francisco Estuary using data from an intensive study of the low salinity foodweb in 2006–2008 supplemented with long-term monitoring data. A drop in chlorophyll concentration in 1987 had previously been linked to grazing by the introduced clam Potamocorbula amurensis, but numerous changes in the estuary may be linked to the continued low chlorophyll. We asked whether phytoplankton continued to be suppressed by grazing and what proportion of the grazing was by benthic bivalves. A mass balance of phytoplankton biomass included estimates of primary production and grazing by microzooplankton, mesozooplankton, and clams. Grazing persistently exceeded net phytoplankton growth especially for larger cells, and grazing by microzooplankton often exceeded that by clams. A subsidy of phytoplankton from other regions roughly balanced the excess of grazing over growth. Thus, the influence of bivalve grazing on phytoplankton biomass can be understood only in the context of limits on phytoplankton growth, total grazing, and transport.

  9. XML as a format of expression of Object-Oriented Petri Nets

    Directory of Open Access Journals (Sweden)

    Petr Jedlička

    2004-01-01

    Full Text Available A number of object-oriented (OO variants have so far been devised for Petri Nets (PN. However, none of these variants has ever been described using an open, independent format – such as XML. This article suggests several possibilities and advantages of such a description. The outlined XML language definition for the description of object-oriented Petri Nets (OOPN is based on XMI (description of UML object-oriented models, SOX (simple description of general OO systems and PNML (an XML-based language used for the description of structured and modular PN. For OOPN, the XML form of description represents a standard format for storing as well as for transfer between various OOPN-processing (analysis, simulation, ... tools.

  10. Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance.

    Science.gov (United States)

    Leshan, Rebecca L; Greenwald-Yarnell, Megan; Patterson, Christa M; Gonzalez, Ian E; Myers, Martin G

    2012-05-01

    Few effective measures exist to combat the worldwide obesity epidemic(1), and the identification of potential therapeutic targets requires a deeper understanding of the mechanisms that control energy balance. Leptin, an adipocyte-derived hormone that signals the long-term status of bodily energy stores, acts through multiple types of leptin receptor long isoform (LepRb)-expressing neurons (called here LepRb neurons) in the brain to control feeding, energy expenditure and endocrine function(2-4). The modest contributions to energy balance that are attributable to leptin action in many LepRb populations(5-9) suggest that other previously unidentified hypothalamic LepRb neurons have key roles in energy balance. Here we examine the role of LepRb in neuronal nitric oxide synthase (NOS1)-expressing LebRb (LepRb(NOS1)) neurons that comprise approximately 20% of the total hypothalamic LepRb neurons. Nos1(cre)-mediated genetic ablation of LepRb (Lepr(Nos1KO)) in mice produces hyperphagic obesity, decreased energy expenditure and hyperglycemia approaching that seen in whole-body LepRb-null mice. In contrast, the endocrine functions in Lepr(Nos1KO) mice are only modestly affected by the genetic ablation of LepRb in these neurons. Thus, hypothalamic LepRb(NOS1) neurons are a key site of action of the leptin-mediated control of systemic energy balance.

  11. Environment or development? Lifetime net CO2 exchange and control of the expression of Crassulacean acid metabolism in Mesembryanthemum crystallinum.

    Science.gov (United States)

    Winter, Klaus; Holtum, Joseph A M

    2007-01-01

    The relative influence of plant age and environmental stress signals in triggering a shift from C(3) photosynthesis to Crassulacean acid metabolism (CAM) in the annual halophytic C(3)-CAM species Mesembryanthemum crystallinum was explored by continuously monitoring net CO(2) exchange of whole shoots from the seedling stage until seed set. Plants exposed to high salinity (400 mm NaCl) in hydroponic culture solution or grown in saline-droughted soil acquired between 11% and 24% of their carbon via net dark CO(2) uptake involving CAM. In contrast, plants grown under nonsaline, well-watered conditions were capable of completing their life cycle by operating in the C(3) mode without ever exhibiting net CO(2) uptake at night. These observations are not consistent with the widely expressed view that the induction of CAM by high salinity in M. crystallinum represents an acceleration of preprogrammed developmental processes. Rather, our study demonstrates that the induction of the CAM pathway for carbon acquisition in M. crystallinum is under environmental control.

  12. Effect of propolis ethanol extract on myostatin gene expression and muscle morphometry of Nile tilapia in net cages.

    Science.gov (United States)

    Buck, E L; Mizubuti, I Y; Alfieri, A A; Otonel, R A A; Buck, L Y; Souza, F P; Prado-Calixto, O P; Poveda-Parra, A R; Alexandre Filho, L; Lopera-Barrero, N M

    2017-03-16

    Propolis can be used as growth enhancer due to its antimicrobial, antioxidant, and immune-stimulant properties, but its effects on morphometry and muscle gene expression are largely unknown. The present study evaluates the influence of propolis on muscle morphometry and myostatin gene expression in Nile tilapia (Oreochromis niloticus) bred in net cages. Reversed males (GIFT strain) with an initial weight of 170 ± 25 g were distributed in a (2 x 4) factorial scheme, with two diets (DPRO, commercial diet with 4% propolis ethanol extract and DCON, commercial diet without propolis, control) and four assessment periods (0, 35, 70, and 105 experimental days). Muscles were evaluated at each assessment period. Histomorphometric analysis classified the fiber diameters into four groups: 50 μm. RT-qPCR was performed to assess myostatin gene expression. Fibers 30 µm (30-50 and > 50 µm) at 70 days were 25.39% and 40.07% for DPRO and DCON, respectively. There was greater myostatin gene expression at 105 days, averaging 1.93 and 1.89 for DCON and DPRO, respectively, with no significant difference in any of the analyzed periods. Propolis ethanol extract did not affect the diameter of muscle fibers or the gene expression of myostatin. Future studies should describe the mechanisms of natural products' effects on muscle growth and development since these factors are highly relevant for fish production performance.

  13. Assessing wildlife benefits and carbon storage from restored and natural coastal marshes in the Nisqually River Delta: Determining marsh net ecosystem carbon balance

    Science.gov (United States)

    Anderson, Frank; Bergamaschi, Brian; Windham-Myers, Lisamarie; Woo, Isa; De La Cruz, Susan; Drexler, Judith; Byrd, Kristin; Thorne, Karen M.

    2016-06-24

    Working in partnership since 1996, the U.S. Fish and Wildlife Service and the Nisqually Indian Tribe have restored 902 acres of tidally influenced coastal marsh in the Nisqually River Delta (NRD), making it the largest estuary-restoration project in the Pacific Northwest to date. Marsh restoration increases the capacity of the estuary to support a diversity of wildlife species. Restoration also increases carbon (C) production of marsh plant communities that support food webs for wildlife and can help mitigate climate change through long-term C storage in marsh soils.In 2015, an interdisciplinary team of U.S. Geological Survey (USGS) researchers began to study the benefits of carbon for wetland wildlife and storage in the NRD. Our primary goals are (1) to identify the relative importance of the different carbon sources that support juvenile chinook (Oncorhynchus tshawytscha) food webs and contribute to current and historic peat formation, (2) to determine the net ecosystem carbon balance (NECB) in a reference marsh and a restoration marsh site, and (3) to model the sustainability of the reference and restoration marshes under projected sea-level rise conditions along with historical vegetation change. In this fact sheet, we focus on the main C sources and exchanges to determine NECB, including carbon dioxide (CO2) uptake through plant photosynthesis, the loss of CO2 through plant and soil respiration, emissions of methane (CH4), and the lateral movement or leaching loss of C in tidal waters.

  14. AIRE expressing marginal zone dendritic cells balances adaptive immunity and T-follicular helper cell recruitment.

    Science.gov (United States)

    Lindmark, Evelina; Chen, Yunying; Georgoudaki, Anna-Maria; Dudziak, Diana; Lindh, Emma; Adams, William C; Loré, Karin; Winqvist, Ola; Chambers, Benedict J; Karlsson, Mikael C I

    2013-05-01

    Autoimmune polyendocrine syndrome Type I (APS I) results in multiple endocrine organ destruction and is caused by mutations in the Autoimmune regulator gene (AIRE). In the thymic stroma, cells expressing the AIRE gene dictate T cell education and central tolerance. Although this function is the most studied, AIRE is also expressed in the periphery in DCs and stromal cells. Still, how AIRE regulated transcription modifies cell behaviour in the periphery is largely unknown. Here we show that AIRE is specifically expressed by 33D1(+) DCs and dictates the fate of antibody secreting cell movement within the spleen. We also found that AIRE expressing 33D1(+) DCs expresses self-antigens as exemplified by the hallmark gene insulin. Also, as evidence for a regulatory function, absence of Aire in 33D1(+) DCs led to reduced levels of the chemokine CXCL12 and increased co-stimulatory properties. This resulted in altered activation and recruitment of T-follicular helper cells and germinal centre B cells. The altered balance leads to a change of the early response to a T cell-dependent antigen in Aire(-/-) mice. These findings add to the understanding of how specific DC subtypes regulate the early responses during T cell-dependent antibody responses within the spleen and further define the role of AIRE in the periphery as regulator of self-antigen expression and lymphocyte migration. Copyright © 2012 Elsevier Ltd. All rights reserved.

  15. Regulation of Energy Balance via BDNF Expressed in Nonparaventricular Hypothalamic Neurons.

    Science.gov (United States)

    Yang, Haili; An, Juan Ji; Sun, Chao; Xu, Baoji

    2016-05-01

    Brain-derived neurotrophic factor (BDNF) expressed in the paraventricular hypothalamus (PVH) has been shown to play a key role in regulating energy intake and energy expenditure. BDNF is also expressed in other hypothalamic nuclei; however, the role in the control of energy balance for BDNF produced in these structures remains largely unknown. We found that deleting the Bdnf gene in the ventromedial hypothalamus (VMH) during embryogenesis using the Sf1-Cre transgene had no effect on body weight in mice. In contrast, deleting the Bdnf gene in the adult VMH using Cre-expressing virus led to significant hyperphagia and obesity. These observations indicate that the lack of a hyperphagia phenotype in the Sf1-Cre/Bdnf mutant mice is likely due to developmental compensation. To investigate the role of BDNF expressed in other hypothalamic areas, we employed the hypothalamus-specific Nkx2.1-Cre transgene to delete the Bdnf gene. We found that the Nkx2.1-Cre transgene could abolish BDNF expression in many hypothalamic nuclei, but not in the PVH, and that the resulting mutant mice developed modest obesity due to reduced energy expenditure. Thus, BDNF produced in the VMH plays a role in regulating energy intake. Furthermore, BDNF expressed in hypothalamic areas other than PVH and VMH is also involved in the control of energy expenditure.

  16. Mammary gene expression profiles during an intramammary challenge reveal potential mechanisms linking negative energy balance with impaired immune response

    DEFF Research Database (Denmark)

    Moyes, Kasey; Drackley, J K; Morin, D E

    2010-01-01

    Our objective was to compare mammary tissue gene expression profiles during a Streptococcus uberis (S. uberis) mastitis challenge between lactating cows subjected to dietary-induced negative energy balance (NEB; n = 5) and cows fed ad libitum to maintain positive energy balance (PEB; n = 5...... feed restriction, one rear mammary quarter of each cow was inoculated with 5,000 cfu of S. uberis (O140J). At 20 h post-inoculation, S. uberis-infected mammary quarters from all cows were biopsied for RNA extraction. Energy balance (NEB vs. PEB) resulted in 287 differentially expressed genes (DEG; FDR...

  17. Drosophila p53 controls Notch expression and balances apoptosis and proliferation.

    Science.gov (United States)

    Simón, Rocío; Aparicio, Ricardo; Housden, Ben E; Bray, Sarah; Busturia, Ana

    2014-10-01

    A balance between cell proliferation and apoptosis is important for normal development and tissue homeostasis. Under stress conditions, the conserved tumor suppressor and transcription factor Dp53 induces apoptosis to contribute to the maintenance of homeostasis. However, in some cases Dp53-induced apoptosis results in the proliferation of surrounding non-apoptotic cells. To gain insight into the Dp53 function in the control of apoptosis and proliferation, we studied the interaction between the Drosophila Dp53 and Notch genes. We present evidence that simultaneous reduction of Dp53 and Notch function synergistically increases the wing phenotype of Notch heterozygous mutant flies. Further, we found that a Notch cis-regulatory element is responsive to loss and gain of Dp53 function and that over-expression of Dp53 up-regulates Notch mRNA and protein expression. These findings suggest not only that Dp53 and Notch act together to control wing development but also indicate that Dp53 transcriptionally regulates Notch expression. Moreover, using Notch  gain and loss of function mutations we examined the relevance of Dp53 and Notch interactions in the process of Dp53-apoptosis induced proliferation. Results show that proliferation induced by Dp53 over-expression is dependent on Notch, thus identifying Notch as a new player in Dp53-induced proliferation. Interestingly, we found that Dp53-induced Notch activation and proliferation occurs even under conditions where apoptosis was inhibited. Our findings highlight the conservation between flies and vertebrates of the Dp53 and Notch cross-talk and suggest that Dp53 has a dual role regulating cell death and proliferation gene networks to control the homeostatic balance between apoptosis and proliferation.

  18. A Balanced Tissue Composition Reveals New Metabolic and Gene Expression Markers in Prostate Cancer.

    Directory of Open Access Journals (Sweden)

    May-Britt Tessem

    Full Text Available Molecular analysis of patient tissue samples is essential to characterize the in vivo variability in human cancers which are not accessible in cell-lines or animal models. This applies particularly to studies of tumor metabolism. The challenge is, however, the complex mixture of various tissue types within each sample, such as benign epithelium, stroma and cancer tissue, which can introduce systematic biases when cancers are compared to normal samples. In this study we apply a simple strategy to remove such biases using sample selections where the average content of stroma tissue is balanced between the sample groups. The strategy is applied to a prostate cancer patient cohort where data from MR spectroscopy and gene expression have been collected from and integrated on the exact same tissue samples. We reveal in vivo changes in cancer-relevant metabolic pathways which are otherwise hidden in the data due to tissue confounding. In particular, lowered levels of putrescine are connected to increased expression of SRM, reduced levels of citrate are attributed to upregulation of genes promoting fatty acid synthesis, and increased succinate levels coincide with reduced expression of SUCLA2 and SDHD. In addition, the strategy also highlights important metabolic differences between the stroma, epithelium and prostate cancer. These results show that important in vivo metabolic features of cancer can be revealed from patient data only if the heterogeneous tissue composition is properly accounted for in the analysis.

  19. Expression and Function of Transmembrane-4 Superfamily (Tetraspanin Proteins in Osteoclasts: Reciprocal Roles of Tspan-5 and NET-6 during Osteoclastogenesis

    Directory of Open Access Journals (Sweden)

    Kaori Iwai

    2007-01-01

    Conclusions: These data indicate that a diversity of tetraspanins is expressed in osteoclast precursors, and that cell fusion during osteoclastogenesis is regulated by cooperation of distinct tetraspanin family proteins such as Tspan-5 and NET-6. This study indicates that functional alterations of tetraspanin family proteins may have therapeutic potential in diseases where osteoclasts play a major role, such as rheumatoid arthritis and osteoporosis.

  20. net/files/pics/CEU.gif"/> The construction of work–life balance: The experience of Black employees in a call-centre environment

    OpenAIRE

    Sonia C.B. Potgieter; Antoni Barnard

    2010-01-01

    Orientation: Work–life balance, as a crucial aspect of employee and organisational wellness, remains an interesting field of research, especially due to the changing demographic employee profile.Research purpose: The objective of the study was to explore Black employees’ construction of work–life balance in a customer care environment.Motivation for the study: The conceptual debate regarding the construct of work–life balance in general as well as limited qualitative research with regard to B...

  1. GEM2Net: from gene expression modeling to -omics networks, a new CATdb module to investigate Arabidopsis thaliana genes involved in stress response.

    Science.gov (United States)

    Zaag, Rim; Tamby, Jean Philippe; Guichard, Cécile; Tariq, Zakia; Rigaill, Guillem; Delannoy, Etienne; Renou, Jean-Pierre; Balzergue, Sandrine; Mary-Huard, Tristan; Aubourg, Sébastien; Martin-Magniette, Marie-Laure; Brunaud, Véronique

    2015-01-01

    CATdb (http://urgv.evry.inra.fr/CATdb) is a database providing a public access to a large collection of transcriptomic data, mainly for Arabidopsis but also for other plants. This resource has the rare advantage to contain several thousands of microarray experiments obtained with the same technical protocol and analyzed by the same statistical pipelines. In this paper, we present GEM2Net, a new module of CATdb that takes advantage of this homogeneous dataset to mine co-expression units and decipher Arabidopsis gene functions. GEM2Net explores 387 stress conditions organized into 18 biotic and abiotic stress categories. For each one, a model-based clustering is applied on expression differences to identify clusters of co-expressed genes. To characterize functions associated with these clusters, various resources are analyzed and integrated: Gene Ontology, subcellular localization of proteins, Hormone Families, Transcription Factor Families and a refined stress-related gene list associated to publications. Exploiting protein-protein interactions and transcription factors-targets interactions enables to display gene networks. GEM2Net presents the analysis of the 18 stress categories, in which 17,264 genes are involved and organized within 681 co-expression clusters. The meta-data analyses were stored and organized to compose a dynamic Web resource. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  2. Effect of prolonged intravenous glucose and essential amino acid infusion on nitrogen balance, muscle protein degradation and ubiquitin-conjugating enzyme gene expression in calves

    Directory of Open Access Journals (Sweden)

    Scaife Jes R

    2008-02-01

    Full Text Available Abstract Background Intravenous infusions of glucose and amino acids increase both nitrogen balance and muscle accretion. We hypothesised that co-infusion of glucose (to stimulate insulin and essential amino acids (EAA would act additively to improve nitrogen balance by decreasing muscle protein degradation in association with alterations in muscle expression of components of the ubiquitin-proteasome proteolytic pathway. Methods We examined the effect of a 5 day intravenous infusions of saline, glucose, EAA and glucose + EAA, on urinary nitrogen excretion and muscle protein degradation. We carried out the study in 6 restrained calves since ruminants offer the advantage that muscle protein degradation can be assessed by excretion of 3 methyl-histidine and multiple muscle biopsies can be taken from the same animal. On the final day of infusion blood samples were taken for hormone and metabolite measurement and muscle biopsies for expression of ubiquitin, the 14-kDa E2 ubiquitin conjugating enzyme, and proteasome sub-units C2 and C8. Results On day 5 of glucose infusion, plasma glucose, insulin and IGF-1 concentrations were increased while urea nitrogen excretion and myofibrillar protein degradation was decreased. Co-infusion of glucose + EAA prevented the loss of urinary nitrogen observed with EAA infusions alone and enhanced the increase in plasma IGF-1 concentration but there was no synergistic effect of glucose + EAA on the decrease in myofibrillar protein degradation. Muscle mRNA expression of the ubiquitin conjugating enzyme, 14-kDa E2 and proteasome sub-unit C2 were significantly decreased, after glucose but not amino acid infusions, and there was no further response to the combined infusions of glucose + EAA. Conclusion Prolonged glucose infusion decreases myofibrillar protein degradation, prevents the excretion of infused EAA, and acts additively with EAA to increase plasma IGF-1 and improve net nitrogen balance. There was no evidence of

  3. Expression of perilipins in human skeletal muscle in vitro and in vivo in relation to diet, exercise and energy balance

    DEFF Research Database (Denmark)

    Gjelstad, I M F; Haugen, F; Gulseth, H L

    2011-01-01

    , enhanced the expression of perilipin 2 and 3. Perilipin 1 mRNA correlated positively with body fat mass, whereas none of the perilipins were associated with insulin sensitivity. In conclusion, all perilipins mRNAs were expressed in human skeletal muscle. Diet as well as endurance exercise modulated......The perilipin proteins enclose intracellular lipid droplets. We describe the mRNA expression of the five perilipins in human skeletal muscle in relation to fatty acid supply, exercise and energy balance. We observed that all perilipins were expressed in skeletal muscle biopsies with the highest m......RNA levels of perilipin 2, 4 and 5. Cultured myotubes predominantly expressed perilipin 2 and 3. In vitro, incubation of myotubes with fatty acids enhanced mRNA expression of perilipin 1, 2 and 4. In vivo, low fat diet increased mRNA levels of perilipin 3 and 4. Endurance training, but not strength training...

  4. Developmental switching in Physarum polycephalum: Petri net analysis of single cell trajectories of gene expression indicates responsiveness and genetic plasticity of the Waddington quasipotential landscape

    Science.gov (United States)

    Werthmann, Britta; Marwan, Wolfgang

    2017-11-01

    The developmental switch to sporulation in Physarum polycephalum is a phytochrome-mediated far-red light-induced cell fate decision that synchronously encompasses the entire multinucleate plasmodial cell and is associated with extensive reprogramming of the transcriptome. By repeatedly taking samples of single cells after delivery of a light stimulus pulse, we analysed differential gene expression in two mutant strains and in a heterokaryon of the two strains all of which display a different propensity for making the cell fate decision. Multidimensional scaling of the gene expression data revealed individually different single cell trajectories eventually leading to sporulation. Characterization of the trajectories as walks through states of gene expression discretized by hierarchical clustering allowed the reconstruction of Petri nets that model and predict the observed behavior. Structural analyses of the Petri nets indicated stimulus- and genotype-dependence of both, single cell trajectories and of the quasipotential landscape through which these trajectories are taken. The Petri net-based approach to the analysis and decomposition of complex cellular responses and of complex mutant phenotypes may provide a scaffold for the data-driven reconstruction of causal molecular mechanisms that shape the topology of the quasipotential landscape.

  5. Net Zero Energy Buildings

    DEFF Research Database (Denmark)

    Marszal, Anna Joanna; Bourrelle, Julien S.; Musall, Eike

    2010-01-01

    and identify possible renewable energy supply options which may be considered in calculations. Finally, the gap between the methodology proposed by each organisation and their respective national building code is assessed; providing an overview of the possible changes building codes will need to undergo......The international cooperation project IEA SHC Task 40 / ECBCS Annex 52 “Towards Net Zero Energy Solar Buildings”, attempts to develop a common understanding and to set up the basis for an international definition framework of Net Zero Energy Buildings (Net ZEBs). The understanding of such buildings...... parameters used in the calculations are discussed and the various renewable supply options considered in the methodologies are summarised graphically. Thus, the paper helps to understand different existing approaches to calculate energy balance in Net ZEBs, highlights the importance of variables selection...

  6. Estimating agro-ecosystem carbon balance of northern Japan, and comparing the change in carbon stock by soil inventory and net biome productivity

    Energy Technology Data Exchange (ETDEWEB)

    Li, Xi, E-mail: icy124@hotmail.com [School of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu 610500 (China); Graduate school of Agriculture, Hokkaido University, Kita 9 Nishi 9, Kita-ku, Sapporo 060-8589 (Japan); Toma, Yo [Faculty of Agriculture, Ehime University, 3-5-7, Tarumi, Matsuyama 790-8566, Ehime (Japan); Yeluripati, Jagadeesh [The James Hutton Institute, Craigiebuckler, Aberdeen AB15 8QH, Scotland (United Kingdom); Iwasaki, Shinya [Graduate school of Agriculture, Hokkaido University, Kita 9 Nishi 9, Kita-ku, Sapporo 060-8589 (Japan); Bellingrath-Kimura, Sonoko D. [Leibniz Centre for Agricultural Landscape Research, Institute of Land Use Systems (Germany); Jones, Edward O. [Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London (United Kingdom); Hatano, Ryusuke [Graduate school of Agriculture, Hokkaido University, Kita 9 Nishi 9, Kita-ku, Sapporo 060-8589 (Japan)

    2016-06-01

    Soil C sequestration in croplands is deemed to be one of the most promising greenhouse gas mitigation options for agriculture. We have used crop-level yields, modeled heterotrophic respiration (Rh) and land use data to estimate spatio-temporal changes in regional scale net primary productivity (NPP), plant C inputs, and net biome productivity (NBP) in northern Japan's arable croplands and grasslands for the period of 1959–2011. We compared the changes in C stocks derived from estimated NBP and using repeated inventory datasets for each individual land use type from 2005 to 2011. For the entire study region of 2193 ha, overall annual plant C inputs to the soil constituted 37% of total region NPP. Plant C inputs in upland areas (excluding bush/fallow) could be predicted by climate variables. Overall NBP for all land use types increased from − 1.26 Mg C ha{sup −1} yr{sup −1} in 1959–0.26 Mg C ha{sup −1} yr{sup −1} in 2011. However, upland and paddy fields showed a decreased in NBP over the period of 1959–2011, under the current C input scenario. From 1988, an increase in agricultural abandonment (bush/fallow) and grassland cover caused a slow increase in the regional C pools. The comparison of carbon budgets using the NBP estimation method and the soil inventory method indicated no significant difference between the two methods. Our results showed C loss in upland crops, paddy fields and sites that underwent land use change from paddy field to upland sites. We also show C gain in grassland from 2005 to 2011. An underestimation of NBP or an overestimation of repeated C inventories cannot be excluded, but either method may be suitable for tracking absolute changes in soil C, considering the uncertainty associated with these methods. - Highlights: • We compared C stocks change by two methods: (i) net biome productivity (NBP) and (ii) soil inventory. • Variation in net primary productivity (NPP), plant C input, NBP can be predicted by climate

  7. Modelling daily to seasonal carbon fluxes and annual net ecosystem carbon balance of cereal grain-cropland using DailyDayCent: A model data comparison

    OpenAIRE

    Chabbi, Abad; Smith, Pete

    2018-01-01

    Croplands are important not only for food and fibre, but also for their global climate change mitigation and carbon (C) sequestration potentials. Measurements and modelling of daily C fluxes and annual C balance, which are needed for optimizing such global potentials in croplands, are difficult since many measurements, and the correct simulation of different ecosystem processes are needed. In the present study, a biogeochemical ecosystem model (DailyDayCent) was applied to simulate daily to s...

  8. Net Locality

    DEFF Research Database (Denmark)

    de Souza e Silva, Adriana Araujo; Gordon, Eric

    Provides an introduction to the new theory of Net Locality and the profound effect on individuals and societies when everything is located or locatable. Describes net locality as an emerging form of location awareness central to all aspects of digital media, from mobile phones, to Google Maps...... of emerging technologies, from GeoCities to GPS, Wi-Fi, Wiki Me, and Google Android....

  9. Net Neutrality

    DEFF Research Database (Denmark)

    Savin, Andrej

    2017-01-01

    Repealing “net neutrality” in the US will have no bearing on Internet freedom or security there or anywhere else.......Repealing “net neutrality” in the US will have no bearing on Internet freedom or security there or anywhere else....

  10. Estimating agro-ecosystem carbon balance of northern Japan, and comparing the change in carbon stock by soil inventory and net biome productivity.

    Science.gov (United States)

    Li, Xi; Toma, Yo; Yeluripati, Jagadeesh; Iwasaki, Shinya; Bellingrath-Kimura, Sonoko D; Jones, Edward O; Hatano, Ryusuke

    2016-06-01

    Soil C sequestration in croplands is deemed to be one of the most promising greenhouse gas mitigation options for agriculture. We have used crop-level yields, modeled heterotrophic respiration (Rh) and land use data to estimate spatio-temporal changes in regional scale net primary productivity (NPP), plant C inputs, and net biome productivity (NBP) in northern Japan's arable croplands and grasslands for the period of 1959-2011. We compared the changes in C stocks derived from estimated NBP and using repeated inventory datasets for each individual land use type from 2005 to 2011. For the entire study region of 2193 ha, overall annual plant C inputs to the soil constituted 37% of total region NPP. Plant C inputs in upland areas (excluding bush/fallow) could be predicted by climate variables. Overall NBP for all land use types increased from -1.26MgCha(-1)yr(-1) in 1959-0.26 Mg Cha(-1)yr(-1) in 2011. However, upland and paddy fields showed a decreased in NBP over the period of 1959-2011, under the current C input scenario. From 1988, an increase in agricultural abandonment (bush/fallow) and grassland cover caused a slow increase in the regional C pools. The comparison of carbon budgets using the NBP estimation method and the soil inventory method indicated no significant difference between the two methods. Our results showed C loss in upland crops, paddy fields and sites that underwent land use change from paddy field to upland sites. We also show C gain in grassland from 2005 to 2011. An underestimation of NBP or an overestimation of repeated C inventories cannot be excluded, but either method may be suitable for tracking absolute changes in soil C, considering the uncertainty associated with these methods. Copyright © 2016 Elsevier B.V. All rights reserved.

  11. Environment or Development? Lifetime Net CO2 Exchange and Control of the Expression of Crassulacean Acid Metabolism in Mesembryanthemum crystallinum1

    Science.gov (United States)

    Winter, Klaus; Holtum, Joseph A.M.

    2007-01-01

    The relative influence of plant age and environmental stress signals in triggering a shift from C3 photosynthesis to Crassulacean acid metabolism (CAM) in the annual halophytic C3-CAM species Mesembryanthemum crystallinum was explored by continuously monitoring net CO2 exchange of whole shoots from the seedling stage until seed set. Plants exposed to high salinity (400 mm NaCl) in hydroponic culture solution or grown in saline-droughted soil acquired between 11% and 24% of their carbon via net dark CO2 uptake involving CAM. In contrast, plants grown under nonsaline, well-watered conditions were capable of completing their life cycle by operating in the C3 mode without ever exhibiting net CO2 uptake at night. These observations are not consistent with the widely expressed view that the induction of CAM by high salinity in M. crystallinum represents an acceleration of preprogrammed developmental processes. Rather, our study demonstrates that the induction of the CAM pathway for carbon acquisition in M. crystallinum is under environmental control. PMID:17056756

  12. Whey protein effects on energy balance link the intestinal mechanisms of energy absorption with adiposity and hypothalamic neuropeptide gene expression.

    Science.gov (United States)

    Nilaweera, Kanishka N; Cabrera-Rubio, Raul; Speakman, John R; O'Connor, Paula M; McAuliffe, AnneMarie; Guinane, Caitriona M; Lawton, Elaine M; Crispie, Fiona; Aguilera, Mònica; Stanley, Maurice; Boscaini, Serena; Joyce, Susan; Melgar, Silvia; Cryan, John F; Cotter, Paul D

    2017-07-01

    We tested the hypothesis that dietary whey protein isolate (WPI) affects the intestinal mechanisms related to energy absorption and that the resulting energy deficit is compensated by changes in energy balance to support growth. C57BL/6 mice were provided a diet enriched with WPI with varied sucrose content, and the impact on energy balance-related parameters was investigated. As part of a high-sucrose diet, WPI reduced the hypothalamic expression of pro-opiomelanocortin gene expression and increased energy intake. The energy expenditure was unaffected, but epididymal weight was reduced, indicating an energy loss. Notably, there was a reduction in the ileum gene expression for amino acid transporter SLC6a19, glucose transporter 2, and fatty acid transporter 4. The composition of the gut microbiota also changed, where Firmicutes were reduced. The above changes indicated reduced energy absorption through the intestine. We propose that this mobilized energy in the adipose tissue and caused hypothalamic changes that increased energy intake, acting to counteract the energy deficit arising in the intestine. Lowering the sucrose content in the WPI diet increased energy expenditure. This further reduced epididymal weight and plasma leptin, whereupon hypothalamic ghrelin gene expression and the intestinal weight were both increased. These data suggest that when the intestine-adipose-hypothalamic pathway is subjected to an additional energy loss (now in the adipose tissue), compensatory changes attempt to assimilate more energy. Notably, WPI and sucrose content interact to enable the component mechanisms of this pathway. Copyright © 2017 the American Physiological Society.

  13. Balance in Positive Emotional Expressivity across School Contexts Relates to Kindergartners' Adjustment

    Science.gov (United States)

    Hernández, Maciel M.; Eisenberg, Nancy; Valiente, Carlos; Spinrad, Tracy L.; Berger, Rebecca H.; VanSchyndel, Sarah K.; Thompson, Marilyn S.; Southworth, Jody; Silva, Kassondra M.

    2018-01-01

    Positive emotional expressivity has been associated with increased social competence and decreased maladjustment in childhood. However, a few researchers have found null or even positive associations between positive emotional expressivity and maladjustment, which suggests that there may be nuanced associations of positive expressivity, perhaps as…

  14. Understanding Net Zero Energy Buildings

    DEFF Research Database (Denmark)

    Salom, Jaume; Widén, Joakim; Candanedo, José

    2011-01-01

    Although several alternative definitions exist, a Net-Zero Energy Building (Net ZEB) can be succinctly described as a grid-connected building that generates as much energy as it uses over a year. The “net-zero” balance is attained by applying energy conservation and efficiency measures...... and by incorporating renewable energy systems. While based on annual balances, a complete description of a Net ZEB requires examining the system at smaller time-scales. This assessment should address: (a) the relationship between power generation and building loads and (b) the resulting interaction with the power grid....... This paper presents and categorizes quantitative indicators suitable to describe both aspects of the building’s performance. These indicators, named LMGI - Load Matching and Grid Interaction indicators, are easily quantifiable and could complement the output variables of existing building simulation tools...

  15. RESTful NET

    CERN Document Server

    Flanders, Jon

    2008-01-01

    RESTful .NET is the first book that teaches Windows developers to build RESTful web services using the latest Microsoft tools. Written by Windows Communication Foundation (WFC) expert Jon Flanders, this hands-on tutorial demonstrates how you can use WCF and other components of the .NET 3.5 Framework to build, deploy and use REST-based web services in a variety of application scenarios. RESTful architecture offers a simpler approach to building web services than SOAP, SOA, and the cumbersome WS- stack. And WCF has proven to be a flexible technology for building distributed systems not necessa

  16. Petri Nets

    Indian Academy of Sciences (India)

    Associate Professor of. Computer Science and. Automation at the Indian. Institute of Science,. Bangalore. His research interests are broadly in the areas of stochastic modeling and scheduling methodologies for future factories; and object oriented modeling. GENERAL I ARTICLE. Petri Nets. 1. Overview and Foundations.

  17. Petri Nets

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 4; Issue 8. Petri Nets - Overview and Foundations. Y Narahari. General Article Volume 4 Issue 8 August 1999 pp ... Author Affiliations. Y Narahari1. Department ot Computer Science and Automation, Indian Institute of Science, Bangalore 560 012, India.

  18. Media in Post-Conflict Transitions : Balancing Protection Against Violence and Freedom of Expression

    NARCIS (Netherlands)

    Buyse, A.C.

    2015-01-01

    Media are a crucial battleground in post-conflict reconstruction. On the one hand media may ignite tensions and induce renewed violence by spreading dangerous expressions. On the other hand free and diverse media underpin a society that tries to shift from authoritarianism to democracy. From a human

  19. Linear Logic on Petri Nets

    DEFF Research Database (Denmark)

    Engberg, Uffe Henrik; Winskel, Glynn

    This article shows how individual Petri nets form models of Girard's intuitionistic linear logic. It explores questions of expressiveness and completeness of linear logic with respect to this interpretation. An aim is to use Petri nets to give an understanding of linear logic and give some apprai...

  20. Calculation Tool for Determining the Net Energy Gain

    DEFF Research Database (Denmark)

    Laustsen, Jacob Birck; Svendsen, Svend

    2002-01-01

    for windows are presented. Based on these methods a program has been developed that determines the heat loss coefficient, U, and the total solar energy transmittance, g, for windows compounded of specific window components selected from a database. The program calculates the net energy gain for specific....... A proper and direct way to describe the energy performance of windows is by the net energy gain, E, which expresses the energy balance for the window. It is defined as the solar heat gain transmitted in minus the heat loss transmitted out through the window during the heating season. The net energy gain...... is dependent on both the U-values and the g-values. Beyond this it is dependent on the orientation of the windows and the climate and the actual period. This makes it difficult to choose the glazings and windows that are optimal with regard to energy performance in a given case. These facts have aroused a need...

  1. A three-gene expression-based risk score can refine the European LeukemiaNet AML classification.

    Science.gov (United States)

    Wilop, Stefan; Chou, Wen-Chien; Jost, Edgar; Crysandt, Martina; Panse, Jens; Chuang, Ming-Kai; Brümmendorf, Tim H; Wagner, Wolfgang; Tien, Hwei-Fang; Kharabi Masouleh, Behzad

    2016-09-01

    Risk stratification based on cytogenetics of acute myeloid leukemia (AML) remains imprecise. The introduction of novel genetic and epigenetic markers has helped to close this gap and increased the specificity of risk stratification, although most studies have been conducted in specific AML subpopulations. In order to overcome this limitation, we used a genome-wide approach in multiple AML populations to develop a robust prediction model for AML survival. We conducted a genome-wide expression analysis of two data sets from AML patients enrolled into the AMLCG-1999 trial and from the Tumor Cancer Genome Atlas (TCGA) to develop a prognostic score to refine current risk classification and performed a validation on two data sets of the National Taiwan University Hospital (NTUH) and an independent AMLCG cohort. In our training set, using a stringent multi-step approach, we identified a small three-gene prognostic scoring system, named Tri-AML score (TriAS) which highly correlated with overall survival (OS). Multivariate analysis revealed TriAS to be an independent prognostic factor in all tested training and additional validation sets, even including age, current cytogenetic-based risk stratification, and three other recently developed expression-based scoring models for AML. The Tri-AML score allows robust and clinically practical risk stratification for the outcome of AML patients. TriAS substantially refined current ELN risk stratification assigning 44.5 % of the patients into a different risk category.

  2. A metered intake of milk following exercise and thermal dehydration restores whole-body net fluid balance better than a carbohydrate-electrolyte solution or water in healthy young men.

    Science.gov (United States)

    Seery, Suzanne; Jakeman, Philip

    2016-09-01

    Appropriate rehydration and nutrient intake in recovery is a key component of exercise performance. This study investigated whether the recovery of body net fluid balance (NFB) following exercise and thermal dehydration to -2 % of body mass (BM) was enhanced by a metered rate of ingestion of milk (M) compared with a carbohydrate-electrolyte solution (CE) or water (W). In randomised order, seven active men (aged 26·2 (sd 6·1) years) undertook exercise and thermal dehydration to -2 % of BM on three occasions. A metered replacement volume of M, CE or W equivalent to 150 % of the BM loss was then consumed within 2-3 h. NFB was subsequently measured for 5 h from commencement of rehydration. A higher overall NFB in M than CE (P=0·001) and W (P=0·006) was observed, with no difference between CE and W (P=0·69). After 5 h, NFB in M remained positive (+117 (sd 122) ml) compared with basal, and it was greater than W (-539 (sd 390) ml, P=0·011) but not CE (-381 (sd 460) ml, P=0·077, d=1·6). Plasma osmolality (Posm) and K remained elevated above basal in M compared with CE and W. The change in Posm was associated with circulating pre-provasopressin (r s 0·348, Pfluid ingestion acts in synergy with the nutrient composition of M in the restoration of NFB following exercise and thermal dehydration.

  3. Balancing protein similarity and gene co-expression reveals new links between genetic conservation and developmental diversity in invertebrates.

    Science.gov (United States)

    Lefebvre, Céline; Aude, Jean-Christophe; Glémet, Eric; Néri, Christian

    2005-04-15

    To identify genetic conservation relative to precise aspects of developmental diversity, an essential question in computational biology, we developed a new comparative method that allows conserved modules for the best balance between protein sequence similarity and gene co-expression to be constructed, in invertebrates. Our method, referred to as the best-balance constraint procedure (BBCP), yielded 719 functionally conserved modules (FCMs) comprising 2-23 gene pairs. These modules were consistent with the developmental roles of orthologues as inferred from Gene Ontology, RNAi knockouts, InterPro and process-specific microarray data. New relationships were defined between genetic conservation and developmental diversity. Novel gene associations were indeed found in 94% of the FCMs, 150 modules being completely new. A significant proportion of the FCMs (18%, 132 modules) described cell type-specific mechanisms, comprising neuronal, muscle and germ cell signaling, new associations being found in 125 modules. Also found were gene associations for cell fate specification activities previously not highlighted by computational means, e.g. in FCMs containing homeogenes. These data indicate that highly discriminative description of genetic conservation can be deduced using BBCP, and reveal new correlations between cellular and developmental diversity and gene essentiality in invertebrates. christian.neri@broca.inserm.fr For supplementary information, please refer to Bioinformatics online.

  4. Interleukin 6 deficiency modulates the hypothalamic expression of energy balance regulating peptides during pregnancy in mice.

    Directory of Open Access Journals (Sweden)

    Patricia Pazos

    Full Text Available Pregnancy is associated with hyperphagia, increased adiposity and multiple neuroendocrine adaptations. Maternal adipose tissue secretes rising amounts of interleukin 6 (IL6, which acts peripherally modulating metabolic function and centrally increasing energy expenditure and reducing body fat. To explore the role of IL6 in the central mechanisms governing dam's energy homeostasis, early, mid and late pregnant (gestational days 7, 13 and 18 wild-type (WT and Il6 knockout mice (Il6-KO were compared with virgin controls at diestrus. Food intake, body weight and composition as well as indirect calorimetry measurements were performed in vivo. Anabolic and orexigenic peptides: neuropeptide Y (Npy and agouti-related peptide (Agrp; and catabolic and anorectic neuropeptides: proopiomelanocortin (Pomc, corticotrophin and thyrotropin-releasing hormone (Crh and Trh mRNA levels were determined by in situ hybridization. Real time-PCR and western-blot were used for additional tissue gene expression and protein studies. Non-pregnant Il6-KO mice were leaner than WT mice due to a decrease in fat but not in lean body mass. Pregnant Il6-KO mice had higher fat accretion despite similar body weight gain than WT controls. A decreased fat utilization in absence of Il6 might explain this effect, as shown by increased respiratory exchange ratio (RER in virgin Il6-KO mice. Il6 mRNA levels were markedly enhanced in adipose tissue but reduced in hypothalamus of mid and late pregnant WT mice. Trh expression was also stimulated at gestational day 13 and lack of Il6 blunted this effect. Conversely, in late pregnant mice lessened hypothalamic Il6 receptor alpha (Il6ra, Pomc and Crh mRNA were observed. Il6 deficiency during this stage up-regulated Npy and Agrp expression, while restoring Pomc mRNA levels to virgin values. Together these results demonstrate that IL6/IL6Ra system modulates Npy/Agrp, Pomc and Trh expression during mouse pregnancy, supporting a role of IL6 in the

  5. Interleukin 6 deficiency modulates the hypothalamic expression of energy balance regulating peptides during pregnancy in mice.

    Science.gov (United States)

    Pazos, Patricia; Lima, Luis; Casanueva, Felipe F; Diéguez, Carlos; García, María C

    2013-01-01

    Pregnancy is associated with hyperphagia, increased adiposity and multiple neuroendocrine adaptations. Maternal adipose tissue secretes rising amounts of interleukin 6 (IL6), which acts peripherally modulating metabolic function and centrally increasing energy expenditure and reducing body fat. To explore the role of IL6 in the central mechanisms governing dam's energy homeostasis, early, mid and late pregnant (gestational days 7, 13 and 18) wild-type (WT) and Il6 knockout mice (Il6-KO) were compared with virgin controls at diestrus. Food intake, body weight and composition as well as indirect calorimetry measurements were performed in vivo. Anabolic and orexigenic peptides: neuropeptide Y (Npy) and agouti-related peptide (Agrp); and catabolic and anorectic neuropeptides: proopiomelanocortin (Pomc), corticotrophin and thyrotropin-releasing hormone (Crh and Trh) mRNA levels were determined by in situ hybridization. Real time-PCR and western-blot were used for additional tissue gene expression and protein studies. Non-pregnant Il6-KO mice were leaner than WT mice due to a decrease in fat but not in lean body mass. Pregnant Il6-KO mice had higher fat accretion despite similar body weight gain than WT controls. A decreased fat utilization in absence of Il6 might explain this effect, as shown by increased respiratory exchange ratio (RER) in virgin Il6-KO mice. Il6 mRNA levels were markedly enhanced in adipose tissue but reduced in hypothalamus of mid and late pregnant WT mice. Trh expression was also stimulated at gestational day 13 and lack of Il6 blunted this effect. Conversely, in late pregnant mice lessened hypothalamic Il6 receptor alpha (Il6ra), Pomc and Crh mRNA were observed. Il6 deficiency during this stage up-regulated Npy and Agrp expression, while restoring Pomc mRNA levels to virgin values. Together these results demonstrate that IL6/IL6Ra system modulates Npy/Agrp, Pomc and Trh expression during mouse pregnancy, supporting a role of IL6 in the central

  6. Interleukin 6 Deficiency Modulates the Hypothalamic Expression of Energy Balance Regulating Peptides during Pregnancy in Mice

    Science.gov (United States)

    Pazos, Patricia; Lima, Luis; Casanueva, Felipe F.; Diéguez, Carlos; García, María C.

    2013-01-01

    Pregnancy is associated with hyperphagia, increased adiposity and multiple neuroendocrine adaptations. Maternal adipose tissue secretes rising amounts of interleukin 6 (IL6), which acts peripherally modulating metabolic function and centrally increasing energy expenditure and reducing body fat. To explore the role of IL6 in the central mechanisms governing dam's energy homeostasis, early, mid and late pregnant (gestational days 7, 13 and 18) wild-type (WT) and Il6 knockout mice (Il6-KO) were compared with virgin controls at diestrus. Food intake, body weight and composition as well as indirect calorimetry measurements were performed in vivo. Anabolic and orexigenic peptides: neuropeptide Y (Npy) and agouti-related peptide (Agrp); and catabolic and anorectic neuropeptides: proopiomelanocortin (Pomc), corticotrophin and thyrotropin-releasing hormone (Crh and Trh) mRNA levels were determined by in situ hybridization. Real time-PCR and western-blot were used for additional tissue gene expression and protein studies. Non-pregnant Il6-KO mice were leaner than WT mice due to a decrease in fat but not in lean body mass. Pregnant Il6-KO mice had higher fat accretion despite similar body weight gain than WT controls. A decreased fat utilization in absence of Il6 might explain this effect, as shown by increased respiratory exchange ratio (RER) in virgin Il6-KO mice. Il6 mRNA levels were markedly enhanced in adipose tissue but reduced in hypothalamus of mid and late pregnant WT mice. Trh expression was also stimulated at gestational day 13 and lack of Il6 blunted this effect. Conversely, in late pregnant mice lessened hypothalamic Il6 receptor alpha (Il6ra), Pomc and Crh mRNA were observed. Il6 deficiency during this stage up-regulated Npy and Agrp expression, while restoring Pomc mRNA levels to virgin values. Together these results demonstrate that IL6/IL6Ra system modulates Npy/Agrp, Pomc and Trh expression during mouse pregnancy, supporting a role of IL6 in the central

  7. Alterations in expression of Cat-315 epitope of perineuronal nets during normal ageing, and its modulation by an open-channel NMDA receptor blocker, memantine.

    Science.gov (United States)

    Yamada, Jun; Ohgomori, Tomohiro; Jinno, Shozo

    2017-06-15

    The perineuronal net (PNN), a specialized aggregate of the extracellular matrix, is involved in neuroprotection against oxidative stress, which is now recognized as a major contributor to age-related decline in brain functions. In this study, we investigated the age-related molecular changes of PNNs using monoclonal antibody Cat-315, which recognizes human natural killer-1 (HNK-1) glycan on aggrecan-based PNNs. Western blot analysis showed that the expression levels of Cat-315 epitope in the hippocampus were higher in middle-aged (MA, 12-month-old) mice than in young adult (YA, 2-month-old) mice. Although there were no differences in the expression levels of Cat-315 epitope between old age (OA, 20-month-old) and MA mice, Cat-315 immunoreactivity was also detected in astrocytes of OA mice. To focus on Cat-315 epitope in PNNs, we used YA and MA mice in the following experiments. Optical disector analysis showed that there were no differences in the numbers of Cat-315-positive (Cat-315(+) ) PNNs between YA and MA mice. Fluorescence intensity analysis indicated that Cat-315 immunoreactivity in PNNs increased with age in the dorsal hippocampus, which is mainly involved in cognitive functions. Administration of an open-channel blocker of NMDA receptor, memantine, reduced the expression levels of Cat-315 epitope in the hippocampus. Furthermore, the numbers of glutamatergic and GABAergic terminals colocalized with Cat-315 epitope around parvalbumin-positive neurons were decreased by memantine. These findings provide novel insight into the involvement of PNNs in normal brain ageing, and suggest that memantine may counteract the age-related alterations in expression levels of Cat-315 epitope via regulation of its subcellular localization. © 2017 Wiley Periodicals, Inc.

  8. Balancing Sexual Expression and Risk of Harm in Elderly Persons with Dementia.

    Science.gov (United States)

    Abellard, Jessica; Rodgers, Carla; Bales, Alicia L

    2017-12-01

    Assessing decision-making capacity in older individuals with dementia, now known as major neurocognitive disorder (MND), is a complex and challenging endeavor. There is a dearth of literature that touches on the sensitive and controversial topic of sexuality in institutionalized settings, despite the rapid increase in the global population of older individuals. In this article, we assert that evaluations of sexual expression in institutionalized older individuals with MND is essential, as there are concerns specific to risks and benefits of sexual expression in elderly persons with MND that should be considered. Jurisdictions differ in the interpretation of capacity to consent to sexual activity, and there are also discrepancies in policies regarding assessment of sexual activity in residents in long-term care facilities. In addition, there is controversy within the literature regarding how to assess capacity to consent to sexual activity in elderly persons with MND. We discuss some of the proposed methods and consider ways that the evaluee's life narrative can help explore the various prongs of capacity. © 2017 American Academy of Psychiatry and the Law.

  9. Skylab water balance analysis

    Science.gov (United States)

    Leonard, J. I.

    1977-01-01

    The water balance of the Skylab crew was analyzed. Evaporative water loss using a whole body input/output balance equation, water, body tissue, and energy balance was analyzed. The approach utilizes the results of several major Skylab medical experiments. Subsystems were designed for the use of the software necessary for the analysis. A partitional water balance that graphically depicts the changes due to water intake is presented. The energy balance analysis determines the net available energy to the individual crewman during any period. The balances produce a visual description of the total change of a particular body component during the course of the mission. The information is salvaged from metabolic balance data if certain techniques are used to reduce errors inherent in the balance method.

  10. Net accumulation of the Greenland ice sheet

    DEFF Research Database (Denmark)

    Kiilsholm, Sissi; Christensen, Jens Hesselbjerg; Dethloff, Klaus

    2003-01-01

    improvement compared to the driving OAGCM. Estimates of the regional net balance are also better represented by the RCM. In the future climate the net balance for the Greenland Ice Sheet is reduced in all the simulation, but discrepancies between the amounts when based on ECHAM4/OPYC3 and HIRHAM are found....... In both scenarios, the estimated melt rates are larger in HIRHAM than in the driving model....

  11. Energy Balance Regulating Neuropeptides Are Expressed through Pregnancy and Regulated by Interleukin-6 Deficiency in Mouse Placenta

    Science.gov (United States)

    Pazos, Patricia; Lima, Luis; Diéguez, Carlos; García, María C.

    2014-01-01

    The placenta produces a number of signaling molecules including metabolic and reproductive hormones as well as several inflammatory mediators. Among them, Interleukin-6 (IL-6), a well-known immune and metabolic regulator, acts peripherally modulating metabolic function and centrally increasing energy expenditure and reducing body fat. IL-6 interacts with key hypothalamic neuropeptidergic systems controlling energy homeostasis such as those producing the orexigenic/anabolic: neuropeptide Y (NPY) and agouti-related peptide (AgRP) and anorectic/catabolic neuropeptides: proopiomelanocortin (POMC) and cocaine and amphetamine regulated transcript (CART). Human and rat placenta have been identified as source of these neuropeptides, but their expression and regulation in murine placental tissues remain unknown. Therefore, placental mRNA levels of IL-6, NPY, AgRP, POMC, and CART at different pregnancy stages (gestational days 13, 15, and 18) were analyzed by real time PCR, as were the effect of IL-6 deficiency (IL-6 knockout mice) on their placental expression. Our results showed that placenta-derived neuropeptides were regulated by gestational age and IL-6 throughout the second half of mouse pregnancy. These data suggest that IL-6 may participate in the fine tune control of energy balance during pregnancy by extending its action as a metabolic signal to the main organ at the fetomaternal interface: the placenta. PMID:24744782

  12. Estrogen deficiency-induced Ca balance impairment is associated with decrease in expression of epithelial Ca transport proteins in aged female rats.

    Science.gov (United States)

    Dong, Xiao-Li; Zhang, Yan; Wong, Man-Sau

    2014-02-06

    The study is designed to determine whether estrogen and vitamin D endocrine systems interact to regulate calcium (Ca) balance as well as changes in mRNA expression of epithelial Ca transport proteins involved in intestinal and renal Ca transport in aging animals in response to ovariectomy and low dietary Ca intake. Eleven-month-old female sham or ovariectomized (OVX) rats were divided into four groups and fed with either a low-Ca (LCD; 0.1% Ca, 0.65% P) or a high-Ca (HCD; 1.2% Ca, 0.65% P) diet for 12weeks. Ca balance and mRNA expression of Ca transport proteins in the intestine and kidney from rats were systematically studied. OVX rats fed with LCD resulted in a negative Ca balance. LCD suppressed serum Ca in OVX but not sham rats, resulting in an induction of serum PTH and 1,25(OH)2D3 levels. The surge in serum 1,25(OH)2D3 levels in LCD-fed OVX rats was associated with an increase in mRNA expression of intestinal transient receptor potential cation channel (TRPV6) and calbindin D9k (CaBP9k) as well as renal vitamin D receptor (VDR), but such an induction was unable to restore Ca balance in vivo. In contrast, the negative Ca balance was associated with suppression of intestinal plasma membrane Ca pump (PMCA1b) and renal transient receptor potential cation channel (TRPV5), calbindin D28k (CaBP28k) and PMCA1b mRNA expression in aged OVX rats. Negative Ca balance in aged female OVX rats is associated with estrogen-dependent and vitamin D-independent downregulation of epithelial Ca transport protein mRNA expression. Copyright © 2013. Published by Elsevier Inc.

  13. Net Generation

    Directory of Open Access Journals (Sweden)

    Konstantin Lidin

    2010-08-01

    Full Text Available Unlike television, where the role of the viewer is limited by channel changing, the Internet allows to demonstrate your own will, to ask questions and get answers, to express your opinion and, on the whole, to self-actualize. It is the conversational nature of the Internet that gave rise to the most common forms of the Internet addiction: surfing, cybersex and cybercommunication.

  14. WT1 expression in breast cancer disrupts the epithelial/mesenchymal balance of tumour cells and correlates with the metabolic response to docetaxel

    Science.gov (United States)

    Artibani, Mara; Sims, Andrew H.; Slight, Joan; Aitken, Stuart; Thornburn, Anna; Muir, Morwenna; Brunton, Valerie G.; Del-Pozo, Jorge; Morrison, Linda R.; Katz, Elad; Hastie, Nicholas D.; Hohenstein, Peter

    2017-01-01

    WT1 is a transcription factor which regulates the epithelial-mesenchymal balance during embryonic development and, if mutated, can lead to the formation of Wilms’ tumour, the most common paediatric kidney cancer. Its expression has also been reported in several adult tumour types, including breast cancer, and usually correlates with poor outcome. However, published data is inconsistent and the role of WT1 in this malignancy remains unclear. Here we provide a complete study of WT1 expression across different breast cancer subtypes as well as isoform specific expression analysis. Using in vitro cell lines, clinical samples and publicly available gene expression datasets, we demonstrate that WT1 plays a role in regulating the epithelial-mesenchymal balance of breast cancer cells and that WT1-expressing tumours are mainly associated with a mesenchymal phenotype. WT1 gene expression also correlates with CYP3A4 levels and is associated with poorer response to taxane treatment. Our work is the first to demonstrate that the known association between WT1 expression in breast cancer and poor prognosis is potentially due to cancer-related epithelial-to-mesenchymal transition (EMT) and poor chemotherapy response. PMID:28345629

  15. Vascular endothelial growth factor mRNA expression and arteriovenous balance in resonse to prolonged, submaximal exercise in humans

    DEFF Research Database (Denmark)

    Hiscock, N.; Fischer, C.P.; Pilegaard, Henriette

    2003-01-01

    VEGF, regulation of gene expression, exercise, angiogensis, skeletal muscle, peripheral vascular function......VEGF, regulation of gene expression, exercise, angiogensis, skeletal muscle, peripheral vascular function...

  16. Negative energy balance and hepatic gene expression patterns in high-yielding dairy cows during the early postpartum period: a global approach.

    Science.gov (United States)

    McCarthy, S D; Waters, S M; Kenny, D A; Diskin, M G; Fitzpatrick, R; Patton, J; Wathes, D C; Morris, D G

    2010-11-15

    In high-yielding dairy cows the liver undergoes extensive physiological and biochemical changes during the early postpartum period in an effort to re-establish metabolic homeostasis and to counteract the adverse effects of negative energy balance (NEB). These adaptations are likely to be mediated by significant alterations in hepatic gene expression. To gain new insights into these events an energy balance model was created using differential feeding and milking regimes to produce two groups of cows with either a mild (MNEB) or severe NEB (SNEB) status. Cows were slaughtered and liver tissues collected on days 6-7 of the first follicular wave postpartum. Using an Affymetrix 23k oligonucleotide bovine array to determine global gene expression in hepatic tissue of these cows, we found a total of 416 genes (189 up- and 227 downregulated) to be altered by SNEB. Network analysis using Ingenuity Pathway Analysis revealed that SNEB was associated with widespread changes in gene expression classified into 36 gene networks including those associated with lipid metabolism, connective tissue development and function, cell signaling, cell cycle, and metabolic diseases, the three most significant of which are discussed in detail. SNEB cows displayed reduced expression of transcription activators and signal transducers that regulate the expression of genes and gene networks associated with cell signaling and tissue repair. These alterations are linked with increased expression of abnormal cell cycle and cellular proliferation associated pathways. This study provides new information and insights on the effect of SNEB on gene expression in high-yielding Holstein Friesian dairy cows in the early postpartum period.

  17. Reconciling estimates of the contemporary North American carbon balance among terrestrial biosphere models, atmospheric inversions, and a new approach for estimating net ecosystem exchange from inventory-based data

    Science.gov (United States)

    Daniel J. Hayes; David P. Turner; Graham Stinson; A. David Mcguire; Yaxing Wei; Tristram O. West; Linda S. Heath; Bernardus Dejong; Brian G. McConkey; Richard A. Birdsey; Werner A. Kurz; Andrew R. Jacobson; Deborah N. Huntzinger; Yude Pan; W. Mac Post; Robert B. Cook

    2012-01-01

    We develop an approach for estimating net ecosystem exchange (NEE) using inventory-based information over North America (NA) for a recent 7-year period (ca. 2000-2006). The approach notably retains information on the spatial distribution of NEE, or the vertical exchange between land and atmosphere of all non-fossil fuel sources and sinks of CO2,...

  18. NASA Net Zero Energy Buildings Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    Pless, S.; Scheib, J.; Torcellini, P.; Hendron, B.; Slovensky, M.

    2014-10-01

    In preparation for the time-phased net zero energy requirement for new federal buildings starting in 2020, set forth in Executive Order 13514, NASA requested that the National Renewable Energy Laboratory (NREL) to develop a roadmap for NASA's compliance. NASA detailed a Statement of Work that requested information on strategic, organizational, and tactical aspects of net zero energy buildings. In response, this document presents a high-level approach to net zero energy planning, design, construction, and operations, based on NREL's first-hand experience procuring net zero energy construction, and based on NREL and other industry research on net zero energy feasibility. The strategic approach to net zero energy starts with an interpretation of the executive order language relating to net zero energy. Specifically, this roadmap defines a net zero energy acquisition process as one that sets an aggressive energy use intensity goal for the building in project planning, meets the reduced demand goal through energy efficiency strategies and technologies, then adds renewable energy in a prioritized manner, using building-associated, emission- free sources first, to offset the annual energy use required at the building; the net zero energy process extends through the life of the building, requiring a balance of energy use and production in each calendar year.

  19. Pro DLR in NET 4

    CERN Document Server

    Wu, Chaur

    2011-01-01

    Microsoft's Dynamic Language Runtime (DLR) is a platform for running dynamic languages such as Ruby and Python on an equal footing with compiled languages such as C#. Furthermore, the runtime is the foundation for many useful software design and architecture techniques you can apply as you develop your .NET applications. Pro DLR in .NET 4 introduces you to the DLR, showing how you can use it to write software that combines dynamic and static languages, letting you choose the right tool for the job. You will learn the core DLR components such as LINQ expressions, call sites, binders, and dynami

  20. NA-NET numerical analysis net

    Energy Technology Data Exchange (ETDEWEB)

    Dongarra, J. [Tennessee Univ., Knoxville, TN (United States). Dept. of Computer Science]|[Oak Ridge National Lab., TN (United States); Rosener, B. [Tennessee Univ., Knoxville, TN (United States). Dept. of Computer Science

    1991-12-01

    This report describes a facility called NA-NET created to allow numerical analysts (na) an easy method of communicating with one another. The main advantage of the NA-NET is uniformity of addressing. All mail is addressed to the Internet host ``na-net.ornl.gov`` at Oak Ridge National Laboratory. Hence, members of the NA-NET do not need to remember complicated addresses or even where a member is currently located. As long as moving members change their e-mail address in the NA-NET everything works smoothly. The NA-NET system is currently located at Oak Ridge National Laboratory. It is running on the same machine that serves netlib. Netlib is a separate facility that distributes mathematical software via electronic mail. For more information on netlib consult, or send the one-line message ``send index`` to netlib{at}ornl.gov. The following report describes the current NA-NET system from both a user`s perspective and from an implementation perspective. Currently, there are over 2100 members in the NA-NET. An average of 110 mail messages pass through this facility daily.

  1. NA-NET numerical analysis net

    Energy Technology Data Exchange (ETDEWEB)

    Dongarra, J. (Tennessee Univ., Knoxville, TN (United States). Dept. of Computer Science Oak Ridge National Lab., TN (United States)); Rosener, B. (Tennessee Univ., Knoxville, TN (United States). Dept. of Computer Science)

    1991-12-01

    This report describes a facility called NA-NET created to allow numerical analysts (na) an easy method of communicating with one another. The main advantage of the NA-NET is uniformity of addressing. All mail is addressed to the Internet host na-net.ornl.gov'' at Oak Ridge National Laboratory. Hence, members of the NA-NET do not need to remember complicated addresses or even where a member is currently located. As long as moving members change their e-mail address in the NA-NET everything works smoothly. The NA-NET system is currently located at Oak Ridge National Laboratory. It is running on the same machine that serves netlib. Netlib is a separate facility that distributes mathematical software via electronic mail. For more information on netlib consult, or send the one-line message send index'' to netlib{at}ornl.gov. The following report describes the current NA-NET system from both a user's perspective and from an implementation perspective. Currently, there are over 2100 members in the NA-NET. An average of 110 mail messages pass through this facility daily.

  2. Investigations of a Cost-Optimal Zero Energy Balance

    DEFF Research Database (Denmark)

    Marszal, Anna Joanna; Nørgaard, Jesper; Heiselberg, Per

    2012-01-01

    The Net Zero Energy Building (Net ZEB) concept is worldwide recognised as a promising solution for decreasing buildings’ energy use. Nevertheless, a consistent definition of the Net ZEB concept is constantly under discussion. One of the points on the Net ZEB agenda is the zero energy balance...

  3. De Novo Herpes Simplex Virus VP16 Expression Gates a Dynamic Programmatic Transition and Sets the Latent/Lytic Balance during Acute Infection in Trigeminal Ganglia.

    Science.gov (United States)

    Sawtell, Nancy M; Thompson, Richard L

    2016-09-01

    The life long relationship between herpes simplex virus and its host hinges on the ability of the virus to aggressively replicate in epithelial cells at the site of infection and transport into the nervous system through axons innervating the infection site. Interaction between the virus and the sensory neuron represents a pivot point where largely unknown mechanisms lead to a latent or a lytic infection in the neuron. Regulation at this pivot point is critical for balancing two objectives, efficient widespread seeding of the nervous system and host survival. By combining genetic and in vivo in approaches, our studies reveal that the balance between latent and lytic programs is a process occurring early in the trigeminal ganglion. Unexpectedly, activation of the latent program precedes entry into the lytic program by 12 -14hrs. Importantly, at the individual neuronal level, the lytic program begins as a transition out of this acute stage latent program and this escape from the default latent program is regulated by de novo VP16 expression. Our findings support a model in which regulated de novo VP16 expression in the neuron mediates entry into the lytic cycle during the earliest stages of virus infection in vivo. These findings support the hypothesis that the loose association of VP16 with the viral tegument combined with sensory axon length and transport mechanisms serve to limit arrival of virion associated VP16 into neuronal nuclei favoring latency. Further, our findings point to specialized features of the VP16 promoter that control the de novo expression of VP16 in neurons and this regulation is a key component in setting the balance between lytic and latent infections in the nervous system.

  4. Net Ecosystem Carbon Flux

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Net Ecosystem Carbon Flux is defined as the year-over-year change in Total Ecosystem Carbon Stock, or the net rate of carbon exchange between an ecosystem and the...

  5. Aplication of Balanced Scorecard

    OpenAIRE

    Fixová, Markéta

    2011-01-01

    This thesis that deals with the issue of "Application of the Balanced Scorecard method" focuses on establishing a strategy of the K company that makes its business in the field of transport and logistics. For the purposes of this study a method of Balanced Scorecard is used to express the strategic goals. Linking of these is shown in a strategy map. Theoretical part evaluates importance and reasons for chosing the Balanced Scorecard technique. Analysis of current situation finished with the S...

  6. Balance Problems

    Science.gov (United States)

    ... it could be a sign of a balance problem. Balance problems can make you feel unsteady. You may also ... injuries, such as a hip fracture. Some balance problems are due to problems in the inner ear. ...

  7. Serotonin 5-HT2C receptor-independent expression of hypothalamic NOR1, a novel modulator of food intake and energy balance, in mice

    Energy Technology Data Exchange (ETDEWEB)

    Nonogaki, Katsunori, E-mail: knonogaki-tky@umin.ac.jp [Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine (Japan); Department of Lifestyle Medicine, Biomedical Engineering Center, Tohoku University (Japan); Kaji, Takao [Department of Lifestyle Medicine, Biomedical Engineering Center, Tohoku University (Japan); Ohba, Yukie; Sumii, Makiko [Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine (Japan); Wakameda, Mamoru; Tamari, Tomohiro [Charles River Laboratories Japan, Inc. (Japan)

    2009-08-21

    NOR1, Nur77 and Nurr1 are orphan nuclear receptors and members of the NR4A subfamily. Here, we report that the expression of hypothalamic NOR1 was remarkably decreased in mildly obese {beta}-endorphin-deficient mice and obese db/db mice with the leptin receptor mutation, compared with age-matched wild-type mice, whereas there were no genotypic differences in the expression of hypothalamic Nur77 or Nurr1 in these animals. The injection of NOR1 siRNA oligonucleotide into the third cerebral ventricle significantly suppressed food intake and body weight in mice. On the other hand, the decreases in hypothalamic NOR1 expression were not found in non-obese 5-HT2C receptor-deficient mice. Moreover, systemic administration of m-chlorophenylpiperazine (mCPP), a 5-HT2C/1B receptor agonist, had no effect on hypothalamic NOR1 expression, while suppressing food intake in {beta}-endorphin-deficient mice. These findings suggest that 5-HT2C receptor-independent proopiomelanocortin-derived peptides regulate the expression of hypothalamic NOR1, which is a novel modulator of feeding behavior and energy balance.

  8. Professional Enterprise NET

    CERN Document Server

    Arking, Jon

    2010-01-01

    Comprehensive coverage to help experienced .NET developers create flexible, extensible enterprise application code If you're an experienced Microsoft .NET developer, you'll find in this book a road map to the latest enterprise development methodologies. It covers the tools you will use in addition to Visual Studio, including Spring.NET and nUnit, and applies to development with ASP.NET, C#, VB, Office (VBA), and database. You will find comprehensive coverage of the tools and practices that professional .NET developers need to master in order to build enterprise more flexible, testable, and ext

  9. The balance between Foxp3 and Ror-γt expression in peripheral blood is altered by tocilizumab and abatacept in patients with rheumatoid arthritis.

    Science.gov (United States)

    Tada, Yoshifumi; Ono, Nobuyuki; Suematsu, Rie; Tashiro, Satoko; Sadanaga, Yuri; Tokuda, Yukiko; Ono, Yukihide; Nakao, Yoshinobu; Maruyama, Akihito; Ohta, Akihide; Koarada, Syuichi

    2016-07-16

    The balance between Th17 cells and regulatory T (Treg) cells has been shown to play an important role in the development of rheumatoid arthritis (RA). Recent studies have shown that treatment with abatacept (ABT) or tocilizumab (TCZ) affects Th17 and Treg cell populations. Although not unanimously accepted, several reports have shown that Treg cells are decreased by ABT and increased by TCZ, and that Th17 cells are decreased by TCZ. To further investigate the effects of ABT and TCZ on the skewing of T cell populations, we analyzed the expression of master regulators genes of helper T cell lineages following ABT/TCZ treatment of RA patients. Ten patients treated with ABT and 10 patients treated with TCZ were enrolled. Total RNA was extracted from peripheral blood cells at baseline, and after 12 and 24 weeks of therapy. The expression levels of T-bet, GATA3, Foxp3 and Ror-γt were semi-quantified using real-time PCR. The relative expression levels were expressed as the ratios of two genes (T-bet/GATA3, Foxp3/GATA3, Foxp3/T-bet, Foxp3/Ror-γt, Ror-γt/T-bet, Ror-γt/GATA3), and the changes in these ratios with treatment were determined. The Foxp3/Ror-γt ratio was decreased after ABT therapy (0.67 ± 0.16 at 24 weeks, P = 0.0034) but was increased after TCZ therapy (2.00 ± 1.03 at 24 weeks, P = 0.0013). In addition, the Ror-γt/GATA3 ratio was decreased after TCZ therapy (0.78 ± 0.37 at 24 weeks, P = 0.0008). Except for these ratios, no significant skewing in the expression of these factors was detected. No significant relationship between clinical response to the treatment and change in the ratios of these factors was determined. Treatment with TCZ or ABT differently affected the balance between Foxp3 and Ror-γt expression in the peripheral blood of patients with RA.

  10. Expression balances of structural genes in shikimate and flavonoid biosynthesis cause a difference in proanthocyanidin accumulation in persimmon (Diospyros kaki Thunb.) fruit.

    Science.gov (United States)

    Akagi, Takashi; Ikegami, Ayako; Suzuki, Yasuhiko; Yoshida, Junya; Yamada, Masahiko; Sato, Akihiko; Yonemori, Keizo

    2009-10-01

    Persimmon fruits accumulate a large amount of proanthocyanidin (PA) during development. Fruits of pollination-constant and non-astringent (PCNA) type mutants lose their ability to produce PA at an early stage of fruit development, while fruits of the normal (non-PCNA) type remain rich in PA until fully ripened. To understand the molecular mechanism for this difference, we isolated the genes involved in PA accumulation that are differentially expressed between PCNA and non-PCNA, and confirmed their correlation with PA content and composition. The expression of structural genes of the shikimate and flavonoid biosynthetic pathways and genes encoding transferases homologous to those involved in the accumulation of phenolic compounds were downregulated coincidentally only in the PCNA type. Analysis of PA composition using the phloroglucinol method suggested that the amounts of epigallocatechin and its 3-O-gallate form were remarkably low in the PCNA type. In the PCNA type, the genes encoding flavonoid 3'5' hydroxylase (F3'5'H) and anthocyanidin reductase (ANR) for epigallocatechin biosynthesis showed remarkable downregulation, despite the continuous expression level of their competitive genes, flavonoid 3' hydroxylation (F3'H) and leucoanthocyanidin reductase (LAR). We also confirmed that the relative expression levels of F3'5'H to F3'H, and ANR to LAR, were considerably higher, and the PA composition corresponded to the seasonal expression balances in both types. These results suggest that expressions of F3'5'H and ANR are important for PA accumulation in persimmon fruit. Lastly, we tested enzymatic activity of recombinant DkANR in vitro, which is thought to be an important enzyme for PA accumulation in persimmon fruits.

  11. A Sox10(rtTA/+) Mouse Line Allows for Inducible Gene Expression in the Auditory and Balance Organs of the Inner Ear.

    Science.gov (United States)

    Walters, Bradley J; Zuo, Jian

    2015-06-01

    Genetic mouse models provide invaluable tools for discerning gene function in vivo. Tetracycline-inducible systems (Tet-On/Off) provide temporal and cell-type specific control of gene expression, offering an alternative or even complementary approach to existing Cre/LoxP systems. Here we characterized a Sox10(rtTA/+) knock-in mouse line which demonstrates inducible reverse tetracycline trans-activator (rtTA) activity and Tet-On transgene expression in the inner ear following induction with the tetracycline derivative doxycycline (Dox). These Sox10(rtTA/+) mice do not exhibit any readily observable developmental or hearing phenotypes, and actively drive Tet-On transgene expression in Sox10 expressing cells in the inner ear. Sox10(rtTA/+) activity was revealed by multiple Tet-On reporters to be nearly ubiquitous throughout the membranous labyrinth of the developing inner ear, and notably absent from hair cells, tympanic border cells, and ganglion neurons following postnatal Dox inductions. Interestingly, Dox-induced Sox10(rtTA/+) activity declined with induction age, where Tet-On reporters became uninducible in adult cochlear epithelium. Co-administration of the loop diuretic furosemide was able to rescue Dox-induced reporter expression, though this method also caused significant cochlear hair cell loss. Surprisingly, Sox10(rtTA/+) driven reporter expression in the cochlea persists for at least 54 days after cessation of neonatal induction, presumably due to the persistence of Dox within inner ear tissues. These findings highlight the utility of the Sox10(rtTA/+) mouse line as a powerful tool for functional genetic studies of the auditory and balance organs in vivo, but also reveal some important considerations that must be adequately controlled for in future studies that rely upon Tet-On/Off systems.

  12. Reconciling estimates of the contemporary North American carbon balance among terrestrial biosphere models, atmospheric inversions, and a new approach for estimating net ecosystem exchange from inventory-based data

    Science.gov (United States)

    Hayes, Daniel J.; Turner, David P.; Stinson, Graham; McGuire, A. David; Wei, Yaxing; West, Tristram O.; Heath, Linda S.; de Jong, Bernardus; McConkey, Brian G.; Birdsey, Richard A.; Kurz, Werner A.; Jacobson, Andrew R.; Huntzinger, Deborah N.; Pan, Yude; Post, W. Mac; Cook, Robert B.

    2012-01-01

    We develop an approach for estimating net ecosystem exchange (NEE) using inventory-based information over North America (NA) for a recent 7-year period (ca. 2000–2006). The approach notably retains information on the spatial distribution of NEE, or the vertical exchange between land and atmosphere of all non-fossil fuel sources and sinks of CO2, while accounting for lateral transfers of forest and crop products as well as their eventual emissions. The total NEE estimate of a -327 ± 252 TgC yr-1 sink for NA was driven primarily by CO2 uptake in the Forest Lands sector (-248 TgC yr-1), largely in the Northwest and Southeast regions of the US, and in the Crop Lands sector (-297 TgC yr-1), predominantly in the Midwest US states. These sinks are counteracted by the carbon source estimated for the Other Lands sector (+218 TgC yr-1), where much of the forest and crop products are assumed to be returned to the atmosphere (through livestock and human consumption). The ecosystems of Mexico are estimated to be a small net source (+18 TgC yr-1) due to land use change between 1993 and 2002. We compare these inventory-based estimates with results from a suite of terrestrial biosphere and atmospheric inversion models, where the mean continental-scale NEE estimate for each ensemble is -511 TgC yr-1 and -931 TgC yr-1, respectively. In the modeling approaches, all sectors, including Other Lands, were generally estimated to be a carbon sink, driven in part by assumed CO2 fertilization and/or lack of consideration of carbon sources from disturbances and product emissions. Additional fluxes not measured by the inventories, although highly uncertain, could add an additional -239 TgC yr-1 to the inventory-based NA sink estimate, thus suggesting some convergence with the modeling approaches.

  13. Skylab water balance error analysis

    Science.gov (United States)

    Leonard, J. I.

    1977-01-01

    Estimates of the precision of the net water balance were obtained for the entire Skylab preflight and inflight phases as well as for the first two weeks of flight. Quantitative estimates of both total sampling errors and instrumentation errors were obtained. It was shown that measurement error is minimal in comparison to biological variability and little can be gained from improvement in analytical accuracy. In addition, a propagation of error analysis demonstrated that total water balance error could be accounted for almost entirely by the errors associated with body mass changes. Errors due to interaction between terms in the water balance equation (covariances) represented less than 10% of the total error. Overall, the analysis provides evidence that daily measurements of body water changes obtained from the indirect balance technique are reasonable, precise, and relaible. The method is not biased toward net retention or loss.

  14. WaveNet

    Science.gov (United States)

    2015-10-30

    Coastal Inlets Research Program WaveNet WaveNet is a web-based, Graphical-User-Interface ( GUI ) data management tool developed for Corps coastal...generates tabular and graphical information for project planning and design documents. The WaveNet is a web-based GUI designed to provide users with a...data from different sources, and employs a combination of Fortran, Python and Matlab codes to process and analyze data for USACE applications

  15. Coloured Petri Nets

    DEFF Research Database (Denmark)

    Jensen, Kurt

    1991-01-01

    This paper describes how Coloured Petri Nets (CP-nets) have been developed — from being a promising theoretical model to being a full-fledged language for the design, specification, simulation, validation and implementation of large software systems (and other systems in which human beings and...... use of CP-nets — because it means that the function representation and the translations (which are a bit mathematically complex) no longer are parts of the basic definition of CP-nets. Instead they are parts of the invariant method (which anyway demands considerable mathematical skills...

  16. Game Coloured Petri Nets

    DEFF Research Database (Denmark)

    Westergaard, Michael

    2006-01-01

    This paper introduces the notion of game coloured Petri nets. This allows the modeler to explicitly model what parts of the model comprise the modeled system and what parts are the environment of the modeled system. We give the formal definition of game coloured Petri nets, a means of reachability...... analysis of this net class, and an application of game coloured Petri nets to automatically generate easy-to-understand visualizations of the model by exploiting the knowledge that some parts of the model are not interesting from a visualization perspective (i.e. they are part of the environment...

  17. Programming NET Web Services

    CERN Document Server

    Ferrara, Alex

    2007-01-01

    Web services are poised to become a key technology for a wide range of Internet-enabled applications, spanning everything from straight B2B systems to mobile devices and proprietary in-house software. While there are several tools and platforms that can be used for building web services, developers are finding a powerful tool in Microsoft's .NET Framework and Visual Studio .NET. Designed from scratch to support the development of web services, the .NET Framework simplifies the process--programmers find that tasks that took an hour using the SOAP Toolkit take just minutes. Programming .NET

  18. Annotating Coloured Petri Nets

    DEFF Research Database (Denmark)

    Lindstrøm, Bo; Wells, Lisa Marie

    2002-01-01

    -net. An example of such auxiliary information is a counter which is associated with a token to be able to do performance analysis. Modifying colour sets and arc inscriptions in a CP-net to support a specific use may lead to creation of several slightly different CP-nets – only to support the different uses...... a method which makes it possible to associate auxiliary information, called annotations, with tokens without modifying the colour sets of the CP-net. Annotations are pieces of information that are not essential for determining the behaviour of the system being modelled, but are rather added to support...

  19. The garlic allelochemical diallyl disulfide affects tomato root growth by influencing cell division, phytohormone balance and expansin gene expression

    Directory of Open Access Journals (Sweden)

    Fang Cheng

    2016-08-01

    Full Text Available Diallyl disulfide (DADS is a volatile organosulfur compound derived from garlic (Allium sativum L., and it is known as an allelochemical responsible for the strong allelopathic potential of garlic. The anticancer properties of DADS have been studied in experimental animals and various types of cancer cells, but to date, little is known about its mode of action as an allelochemical at the cytological level. The current research presents further studies on the effects of DADS on tomato (Solanum lycopersicum L. seed germination, root growth, mitotic index and cell size in root meristem, as well as the phytohormone levels and expression profile of auxin biosynthesis genes (FZYs, auxin transport genes (SlPINs and expansin genes (EXPs in tomato root. The results showed a biphasic, dose-dependent effect on tomato seed germination and root growth under different DADS concentrations. Lower concentrations (0.01-0.62 mM of DADS significantly promoted root growth, whereas higher levels (6.20-20.67 mM showed inhibitory effects. Cytological observations showed that the cell length of root meristem was increased and that the mitotic activity of meristematic cells in seedling root tips was enhanced at lower concentrations of DADS. In contrast, DADS at higher concentrations inhibited root growth by affecting both the length and division activity of meristematic cells. However, the cell width of the root meristem was not affected. Additionally, DADS increased the IAA and ZR contents of seedling roots in a dose-dependent manner. The influence on IAA content may be mediated by the up-regulation of FZYs and PINs. Further investigation into the underlying mechanism revealed that the expression levels of tomato EXPs were significantly affected by DADS. The expression levels of EXPB2 and beta-expansin precursor were increased after 3 d, and those of EXP1, EXPB3 and EXLB1 were increased after 5 d of DADS treatment (0.41 mM. This result suggests that tomato root growth

  20. Caught in the Net: Perineuronal Nets and Addiction

    Directory of Open Access Journals (Sweden)

    Megan Slaker

    2016-01-01

    Full Text Available Exposure to drugs of abuse induces plasticity in the brain and creates persistent drug-related memories. These changes in plasticity and persistent drug memories are believed to produce aberrant motivation and reinforcement contributing to addiction. Most studies have explored the effect drugs of abuse have on pre- and postsynaptic cells and astrocytes; however, more recently, attention has shifted to explore the effect these drugs have on the extracellular matrix (ECM. Within the ECM are unique structures arranged in a net-like manner, surrounding a subset of neurons called perineuronal nets (PNNs. This review focuses on drug-induced changes in PNNs, the molecules that regulate PNNs, and the expression of PNNs within brain circuitry mediating motivation, reward, and reinforcement as it pertains to addiction.

  1. The European carbon balance. Part 2: croplands

    NARCIS (Netherlands)

    Ciais, P.; Wattenbach, M.; Vuichard, N.; Smith, P.; Piao, S.L.; Don, A.; Luyssaert, S.; Janssens, I.A.; Bondeau, A.; Dechow, R.; Leip, A.; Smith, P.C.; Beer, C.; van der Werf, G.R.; Gervois, S.; Van Oost, K.; Tomelleri, E.; Freibauer, A.; Schulze, E.D.

    2010-01-01

    We estimated the long-term carbon balance [net biome production (NBP)] of European (EU-25) croplands and its component fluxes, over the last two decades. Net primary production (NPP) estimates, from different data sources ranged between 490 and 846 gC m

  2. Modest net autotrophy in the oligotrophic ocean

    Science.gov (United States)

    Letscher, Robert T.; Moore, J. Keith

    2017-04-01

    The metabolic state of the oligotrophic subtropical ocean has long been debated. Net community production (NCP) represents the balance of autotrophic carbon fixation with heterotrophic respiration. Many in vitro NCP estimates based on oxygen incubation methods and the corresponding scaling relationships used to predict the ecosystem metabolic balance have suggested the ocean gyres to be net heterotrophic; however, all in situ NCP methods find net autotrophy. Reconciling net heterotrophy requires significant allochthonous inputs of organic carbon to the oligotrophic gyres to sustain a preponderance of respiration over in situ production. Here we use the first global ecosystem-ocean circulation model that contains representation of the three allochthonous carbon sources to the open ocean, to show that the five oligotrophic gyres exhibit modest net autotrophy throughout the seasonal cycle. Annually integrated rates of NCP vary in the range 1.5-2.2 mol O2 m-2 yr-1 across the five gyre systems; however, seasonal NCP rates are as low as 1 ± 0.5 mmol O2 m-2 d-1 for the North Atlantic. Volumetric NCP rates are heterotrophic below the 10% light level; however, they become net autotrophic when integrated over the euphotic zone. Observational uncertainties when measuring these modest autotrophic NCP rates as well as the metabolic diversity encountered across space and time complicate the scaling up of in vitro measurements to the ecosystem scale and may partially explain the previous reports of net heterotrophy. The oligotrophic ocean is autotrophic at present; however, it could shift toward seasonal heterotrophy in the future as rising temperatures stimulate respiration.

  3. Net zero water

    CSIR Research Space (South Africa)

    Lindeque, M

    2013-01-01

    Full Text Available Is it possible to develop a building that uses a net zero amount of water? In recent years it has become evident that it is possible to have buildings that use a net zero amount of electricity. This is possible when the building is taken off...

  4. SolNet

    DEFF Research Database (Denmark)

    Jordan, Ulrike; Vajen, Klaus; Bales, Chris

    2014-01-01

    SolNet, founded in 2006, is the first coordinated International PhD education program on Solar Thermal Engineering. The SolNet network is coordinated by the Institute of Thermal Engineering at Kassel University, Germany. The network offers PhD courses on solar heating and cooling, conference...

  5. Kunstige neurale net

    DEFF Research Database (Denmark)

    Hørning, Annette

    1994-01-01

    Artiklen beskæftiger sig med muligheden for at anvende kunstige neurale net i forbindelse med datamatisk procession af naturligt sprog, specielt automatisk talegenkendelse.......Artiklen beskæftiger sig med muligheden for at anvende kunstige neurale net i forbindelse med datamatisk procession af naturligt sprog, specielt automatisk talegenkendelse....

  6. Long-term exposure to triphenylphosphate alters hormone balance and HPG, HPI, and HPT gene expression in zebrafish (Danio rerio).

    Science.gov (United States)

    Liu, Xiaoshan; Jung, Dawoon; Jo, Areum; Ji, Kyunghee; Moon, Hyo-Bang; Choi, Kyungho

    2016-09-01

    With the global decline in the use of polybrominated diphenyl ethers, the demand for alternative flame retardants, such as triphenylphosphate (TPP), has increased substantially. Triphenylphosphate is now detected in various environments including aquatic ecosystems worldwide. However, studies on the toxicological consequences of chronic TPP exposure on aquatic organisms are scarce. The zebrafish model was used to investigate the effects of long-term TPP exposure on the endocrine system. Zebrafish embryos were exposed to 5 µg/L, 50 µg/L, or 500 µg/L TPP for 120 d, and hormonal and transcriptional responses were measured along the hypothalamic-pituitary-gonad (HPG) axis, the hypothalamic-pituitary-interrenal (HPI) axis, and the hypothalamic-pituitary-thyroid (HPT) axis. Exposure to TPP significantly increased plasma 17β-estradiol, but decreased 11-ketotestosterone in both sexes. Gene expression data support these changes. In the HPI axis, plasma cortisol and proopiomelanocortin (pomc) and mineralocorticoid receptor transcripts increased in females, but in males cortisol decreased whereas pomc increased (p HPG axis, but modulated the HPI, and HPT axes differently by sex, suggesting that both genomic and nongenomic responses might be involved. Environ Toxicol Chem 2016;35:2288-2296. © 2016 SETAC. © 2016 SETAC.

  7. Infliximab therapy balances regulatory T cells, tumour necrosis factor receptor 2 (TNFR2) expression and soluble TNFR2 in sarcoidosis.

    Science.gov (United States)

    Verwoerd, A; Hijdra, D; Vorselaars, A D M; Crommelin, H A; van Moorsel, C H M; Grutters, J C; Claessen, A M E

    2016-08-01

    Sarcoidosis is a systemic granulomatous disease of unknown aetiology that most commonly affects the lungs. Although elevated levels of regulatory T cells (Tregs ) have been reported, the extent to which they play a role in sarcoidosis pathogenesis remains unclear. Tumour necrosis factor (TNF) is thought to be one of the driving forces behind granuloma formation, illustrated by the efficacy of infliximab in severe sarcoidosis. Tregs express TNF receptor 2 (TNFR2) highly. Here, we examined the influence of infliximab therapy on Tregs and (soluble) TNFR2 levels in sarcoidosis, and correlated these with response to therapy. We observed that relative frequencies of Tregs were significantly higher in patients (n = 54) compared to healthy controls (n = 26; median 6·73 versus 4·36%; P infliximab therapy, suggesting a pathophysiological role of this T cell subset. Interestingly, sTNFR2 levels at baseline differed significantly between responders and non-responders, making it a potential marker in predicting which patients might benefit from infliximab. © 2016 British Society for Immunology.

  8. 47 CFR 32.4100 - Net current deferred operating income taxes.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Net current deferred operating income taxes. 32... Accounts § 32.4100 Net current deferred operating income taxes. (a) This account shall include the balance... appropriate deferred income tax shall be reclassified from Account 4340, Net Noncurrent Deferred Operating...

  9. 47 CFR 32.4370 - Other jurisdictional liabilities and deferred credits-net.

    Science.gov (United States)

    2010-10-01

    ... net of any applicable income tax effects and shall be supported by appropriate subsidiary records... credits-net. 32.4370 Section 32.4370 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED... Balance Sheet Accounts § 32.4370 Other jurisdictional liabilities and deferred credits—net. This account...

  10. Pro NET Best Practices

    CERN Document Server

    Ritchie, Stephen D

    2011-01-01

    Pro .NET Best Practices is a practical reference to the best practices that you can apply to your .NET projects today. You will learn standards, techniques, and conventions that are sharply focused, realistic and helpful for achieving results, steering clear of unproven, idealistic, and impractical recommendations. Pro .NET Best Practices covers a broad range of practices and principles that development experts agree are the right ways to develop software, which includes continuous integration, automated testing, automated deployment, and code analysis. Whether the solution is from a free and

  11. Getting to Net Zero

    Energy Technology Data Exchange (ETDEWEB)

    2016-09-01

    The technology necessary to build net zero energy buildings (NZEBs) is ready and available today, however, building to net zero energy performance levels can be challenging. Energy efficiency measures, onsite energy generation resources, load matching and grid interaction, climatic factors, and local policies vary from location to location and require unique methods of constructing NZEBs. It is recommended that Components start looking into how to construct and operate NZEBs now as there is a learning curve to net zero construction and FY 2020 is just around the corner.

  12. Instant Lucene.NET

    CERN Document Server

    Heydt, Michael

    2013-01-01

    Filled with practical, step-by-step instructions and clear explanations for the most important and useful tasks. A step-by-step guide that helps you to index, search, and retrieve unstructured data with the help of Lucene.NET.Instant Lucene.NET How-to is essential for developers new to Lucene and Lucene.NET who are looking to get an immediate foundational understanding of how to use the library in their application. It's assumed you have programming experience in C# already, but not that you have experience with search techniques such as information retrieval theory (although there will be a l

  13. 3-D force-balanced magnetospheric configurations

    Directory of Open Access Journals (Sweden)

    S. Zaharia

    2004-01-01

    Full Text Available The knowledge of plasma pressure is essential for many physics applications in the magnetosphere, such as computing magnetospheric currents and deriving mag-netosphere-ionosphere coupling. A thorough knowledge of the 3-D pressure distribution has, however, eluded the community, as most in situ pressure observations are either in the ionosphere or the equatorial region of the magnetosphere. With the assumption of pressure isotropy there have been attempts to obtain the pressure at different locations,by either (a mapping observed data (e.g. in the ionosphere along the field lines of an empirical magnetospheric field model, or (b computing a pressure profile in the equatorial plane (in 2-D or along the Sun-Earth axis (in 1-D that is in force balance with the magnetic stresses of an empirical model. However, the pressure distributions obtained through these methods are not in force balance with the empirical magnetic field at all locations. In order to find a global 3-D plasma pressure distribution in force balance with the magnetospheric magnetic field, we have developed the MAG-3-D code that solves the 3-D force balance equation net/22/251/2004/ag-22-251-img1.gif" alt="${vec J} times {vec B} = nabla P$" align="middle" border="0" height="39" width="93"> computationally. Our calculation is performed in a flux coordinate system in which the magnetic field is expressed in terms of Euler potentials as net/22/251/2004/ag-22-251-img2.gif" alt="${vec B} = nabla psi times nabla alpha$" align="middle" border="0" height="39" width="104">. The pressure distribution, net/22/251/2004/ag-22-251-img3.gif" alt="$P = P(psi, alpha$" align="middle" border="0" height="32" width="90">, is prescribed in the equatorial plane and is based on satellite measurements. In addition, computational boundary conditions for ψ surfaces are imposed using empirical field models

  14. PhysioNet

    Data.gov (United States)

    U.S. Department of Health & Human Services — The PhysioNet Resource is intended to stimulate current research and new investigations in the study of complex biomedical and physiologic signals. It offers free...

  15. NetSig

    DEFF Research Database (Denmark)

    Horn, Heiko; Lawrence, Michael S; Chouinard, Candace R

    2018-01-01

    Methods that integrate molecular network information and tumor genome data could complement gene-based statistical tests to identify likely new cancer genes; but such approaches are challenging to validate at scale, and their predictive value remains unclear. We developed a robust statistic (Net......Sig) that integrates protein interaction networks with data from 4,742 tumor exomes. NetSig can accurately classify known driver genes in 60% of tested tumor types and predicts 62 new driver candidates. Using a quantitative experimental framework to determine in vivo tumorigenic potential in mice, we found that Net......Sig candidates induce tumors at rates that are comparable to those of known oncogenes and are ten-fold higher than those of random genes. By reanalyzing nine tumor-inducing NetSig candidates in 242 patients with oncogene-negative lung adenocarcinomas, we find that two (AKT2 and TFDP2) are significantly amplified...

  16. TideNet

    Science.gov (United States)

    2015-10-30

    query tide data sources in a desired geographic region of USA and its territories (Figure 1). Users can select a tide data source through the Google Map ...select data sources according to the desired geographic region. It uses the Google Map interface to display data from different sources. Recent...Coastal Inlets Research Program TideNet The TideNet is a web-based Graphical User Interface (GUI) that provides users with GIS mapping tools to

  17. Building Neural Net Software

    OpenAIRE

    Neto, João Pedro; Costa, José Félix

    1999-01-01

    In a recent paper [Neto et al. 97] we showed that programming languages can be translated on recurrent (analog, rational weighted) neural nets. The goal was not efficiency but simplicity. Indeed we used a number-theoretic approach to machine programming, where (integer) numbers were coded in a unary fashion, introducing a exponential slow down in the computations, with respect to a two-symbol tape Turing machine. Implementation of programming languages in neural nets turns to be not only theo...

  18. Interaction Nets in Russian

    OpenAIRE

    Salikhmetov, Anton

    2013-01-01

    Draft translation to Russian of Chapter 7, Interaction-Based Models of Computation, from Models of Computation: An Introduction to Computability Theory by Maribel Fernandez. "In this chapter, we study interaction nets, a model of computation that can be seen as a representative of a class of models based on the notion of 'computation as interaction'. Interaction nets are a graphical model of computation devised by Yves Lafont in 1990 as a generalisation of the proof structures of linear logic...

  19. Programming NET 35

    CERN Document Server

    Liberty, Jesse

    2009-01-01

    Bestselling author Jesse Liberty and industry expert Alex Horovitz uncover the common threads that unite the .NET 3.5 technologies, so you can benefit from the best practices and architectural patterns baked into the new Microsoft frameworks. The book offers a Grand Tour" of .NET 3.5 that describes how the principal technologies can be used together, with Ajax, to build modern n-tier and service-oriented applications. "

  20. Balanced sampling

    NARCIS (Netherlands)

    Brus, D.J.

    2015-01-01

    In balanced sampling a linear relation between the soil property of interest and one or more covariates with known means is exploited in selecting the sampling locations. Recent developments make this sampling design attractive for statistical soil surveys. This paper introduces balanced sampling

  1. Balancing Act

    Science.gov (United States)

    Part of being an Active, More Powerful You means finding balance in your daily life: taking on the Must-dos and finding time for some Should Dos and Want-to-Dos. Sometimes, emotions and commitments can come into play and upset the balance.

  2. La plataforma .NET

    OpenAIRE

    Fornas Estrada, Miquel

    2008-01-01

    L'aparició de la plataforma .NET Framework ha suposat un canvi molt important en la forma de crear i distribuir aplicacions, degut a que incorpora una sèrie d'innovacions tècniques i productives que simplifiquen molt les tasques necessàries per desenvolupar un projecte. La aparición de la plataforma. NET Framework ha supuesto un cambio muy importante en la forma de crear y distribuir aplicaciones, debido a que incorpora una serie de innovaciones técnicas y productivas que simplifican mucho...

  3. Biological Petri Nets

    CERN Document Server

    Wingender, E

    2011-01-01

    It was suggested some years ago that Petri nets might be well suited to modeling metabolic networks, overcoming some of the limitations encountered by the use of systems employing ODEs (ordinary differential equations). Much work has been done since then which confirms this and demonstrates the usefulness of this concept for systems biology. Petri net technology is not only intuitively understood by scientists trained in the life sciences, it also has a robust mathematical foundation and provides the required degree of flexibility. As a result it appears to be a very promising approach to mode

  4. Petri Nets as Models of Linear Logic

    DEFF Research Database (Denmark)

    Engberg, Uffe Henrik; Winskel, Glynn

    1990-01-01

    The chief purpose of this paper is to appraise the feasibility of Girad's linear logic as a specification language for parallel processes. To this end we propose an interpretation of linear logic in Petri nets, with respect to which we investigate the expressive power of the logic...

  5. Balancing Acts

    Science.gov (United States)

    ... Current Issue Past Issues Special Section: Focus on Communication Balancing Acts Past Issues / Fall 2008 Table of ... It was like watching a movie, but every couple of frames were skipping. It was disorienting," the ...

  6. An Implementation of Nested Pattern Matching in Interaction Nets

    Directory of Open Access Journals (Sweden)

    Abubakar Hassan

    2010-03-01

    Full Text Available Reduction rules in interaction nets are constrained to pattern match exactly one argument at a time. Consequently, a programmer has to introduce auxiliary rules to perform more sophisticated matches. In this paper, we describe the design and implementation of a system for interaction nets which allows nested pattern matching on interaction rules. We achieve a system that provides convenient ways to express interaction net programs without defining auxiliary rules.

  7. Petri Nets-Applications

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 4; Issue 9. Petri Nets - Applications. Y Narahari. General Article Volume 4 Issue 9 September 1999 pp 44-52. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/004/09/0044-0052. Author Affiliations. Y Narahari ...

  8. Safety nets or straitjackets?

    DEFF Research Database (Denmark)

    Ilsøe, Anna

    2012-01-01

    Does regulation of working hours at national and sector level impose straitjackets, or offer safety nets to employees seeking working time flexibility? This article compares legislation and collective agreements in the metal industries of Denmark, Germany and the USA. The industry has historically...

  9. Coloured Petri Nets

    CERN Document Server

    Jensen, Kurt

    2009-01-01

    Coloured Petri Nets (CPN) is a graphical language for modelling and validating concurrent and distributed systems, and other systems in which concurrency plays a major role. This book introduces the constructs of the CPN modelling language and presents the related analysis methods. It provides a comprehensive road map for the practical use of CPN.

  10. Boom Booom Net Radio

    DEFF Research Database (Denmark)

    Grimshaw, Mark Nicholas; Yong, Louisa; Dobie, Ian

    1999-01-01

    of an existing Internet radio station; Boom Booom Net Radio. Whilst necessity dictates some use of technology-related terminology, wherever possible we have endeavoured to keep such jargon to a minimum and to either explain it in the text or to provide further explanation in the appended glossary....

  11. Game Theory .net.

    Science.gov (United States)

    Shor, Mikhael

    2003-01-01

    States making game theory relevant and accessible to students is challenging. Describes the primary goal of GameTheory.net is to provide interactive teaching tools. Indicates the site strives to unite educators from economics, political and computer science, and ecology by providing a repository of lecture notes and tests for courses using…

  12. Coloured Petri Nets

    DEFF Research Database (Denmark)

    Jensen, Kurt; Kristensen, Lars Michael

    Coloured Petri Nets (CPN) is a graphical language for modelling and validating concurrent and distributed systems, and other systems in which concurrency plays a major role. The development of such systems is particularly challenging because of inherent intricacies like possible nondeterminism...

  13. Trade-Offs Associated with Photoprotective Green Fluorescent Protein Expression as Potential Drivers of Balancing Selection for Color Polymorphism in Reef Corals

    Directory of Open Access Journals (Sweden)

    Cathryn Quick

    2018-02-01

    Full Text Available Photodamage of symbiotic algae exposed to thermal stress is involved in mass coral bleaching, a major cause of reef decline. Photoprotection is therefore a vital part of coral stress physiology. Corals produce a variety of green fluorescent protein (GFP-like proteins, some of which screen the symbiotic algae from excess sun light. Different tissue concentrations of these GFP-like proteins distinguish color morphs that are characteristic for many coral species. The question arises whether these pigmentation differences may diversify the niches that can be occupied by corals along the steep light gradient that structures coral reef communities. We assessed the implications of GFP-like protein expression in two color morphs of the symbiotic coral Hydnophora grandis, both associated with the same Symbiodinium sp. (subclade C40. The color morphs of this species (high fluorescent, HF; and low fluorescent, LF, characterized by markedly different contents of a cyan fluorescent protein, were exposed to different quantities of blue light (470 nm that matched the major absorption band of the host pigment (473 nm. High intensities of blue light caused less photodamage to the symbiotic algae of the HF morph and resulted in higher growth rates of these corals compared to representatives of the LF morph. In contrast, under low intensities of blue light, the HF morph showed lower growth rates than the LF morph, indicating that trade-offs are associated with high levels of fluorescent protein expression under this condition. Both morphs showed highest growth rates at medium light intensities with no obvious influence of the tissue pigmentation. Reef coral color polymorphism caused by photoprotective GFP-like proteins may therefore be a product of balancing selection in which high pigment contents may be beneficial at the upper and detrimental at the lower end of the depth distribution range of symbiotic corals. Conversely, color morphs with GFP-like proteins

  14. Food Safety Nets:

    OpenAIRE

    Haggblade, Steven; Diallo, Boubacar; Staatz, John; Theriault, Veronique; Traoré, Abdramane

    2013-01-01

    Food and social safety nets have a history as long as human civilization. In hunter gatherer societies, food sharing is pervasive. Group members who prove unlucky in the short run, hunting or foraging, receive food from other households in anticipation of reciprocal consideration at a later time (Smith 1988). With the emergence of the first large sedentary civilizations in the Middle East, administrative systems developed specifically around food storage and distribution. The ancient Egyptian...

  15. Completeness Results for Linear Logic on Petri Nets

    DEFF Research Database (Denmark)

    Engberg, Uffe Henrik; Winskel, Glynn

    1993-01-01

    Completeness is shown for several versions of Girard's linear logic with respect to Petri nets as the class of models. The strongest logic considered is intuitionistic linear logic, with $otimes$, $-!circ$, &, $oplus$ and the exponential ! (''of course´´), and forms of quantification. This logic...... is shown sound and complete with respect to atomic nets (these include nets in which every transition leads to a nonempty multiset of places). The logic is remarkably expressive, enabling descriptions of the kinds of properties one might wish to show of nets; in particular, negative properties, asserting...

  16. Using WordNet for Building WordNets

    CERN Document Server

    Farreres, X; Farreres, Xavier; Rodriguez, Horacio; Rigau, German

    1998-01-01

    This paper summarises a set of methodologies and techniques for the fast construction of multilingual WordNets. The English WordNet is used in this approach as a backbone for Catalan and Spanish WordNets and as a lexical knowledge resource for several subtasks.

  17. Contribution of parvalbumin and somatostatin-expressing GABAergic neurons to slow oscillations and the balance in beta-gamma oscillations across cortical layers

    Directory of Open Access Journals (Sweden)

    Toshinobu eKuki

    2015-02-01

    Full Text Available Cortical interneurons are classified into several subtypes that contribute to cortical oscillatory activity. Parvalbumin (PV-expressing cells, a type of inhibitory interneuron, are involved in the gamma oscillations of local field potentials (LFPs. Under ketamine-xylazine anesthesia or sleep, mammalian cortical circuits exhibit slow oscillations in which the active-up state and silent-down state alternate at ~1 Hz. The up state is composed of various high-frequency oscillations, including gamma oscillations. However, it is unclear how PV cells and somatostatin (SOM cells contribute to the slow oscillations and the high-frequency oscillations nested in the up state. To address these questions, we used mice lacking glutamate decarboxylase 67, primarily in PV cells (PV-GAD67 mice or in SOM cells (SOM-GAD67 mice. We then compared LFPs between PV-GAD67 mice and SOM-GAD67 mice. PV cells target the proximal regions of pyramidal cells, whereas SOM cells are dendrite-preferring interneurons. We found that the up state was shortened in duration in the PV-GAD67 mice, but tended to be longer in SOM-GAD67 mice. Firing rate tended to increase in PV-GAD67 mice, but tended to decrease in SOM-GAD67 mice. We also found that delta oscillations tended to increase in SOM-GAD67 mice, but tended to decrease in PV-GAD67 mice. Current source density and wavelet analyses were performed to determine the depth profiles of various high-frequency oscillations. High gamma and ripple (60–200 Hz power decreased in the neocortical upper layers specifically in PV-GAD67 mice, but not in SOM-GAD67. In addition, beta power (15–30 Hz increased in the deep layers, specifically in PV-GAD67 mice. These results suggest that PV cells play important roles in persistence of the up state and in the balance between gamma and beta bands across cortical layers, whereas SOM and PV cells may make an asymmetric contribution to regulate up-state and delta oscillations.

  18. Genetic and epigenetic drivers of neuroendocrine tumours (NET).

    Science.gov (United States)

    Di Domenico, Annunziata; Wiedmer, Tabea; Marinoni, Ilaria; Perren, Aurel

    2017-09-01

    Neuroendocrine tumours (NET) of the gastrointestinal tract and the lung are a rare and heterogeneous group of tumours. The molecular characterization and the clinical classification of these tumours have been evolving slowly and show differences according to organs of origin. Novel technologies such as next-generation sequencing revealed new molecular aspects of NET over the last years. Notably, whole-exome/genome sequencing (WES/WGS) approaches underlined the very low mutation rate of well-differentiated NET of all organs compared to other malignancies, while the engagement of epigenetic changes in driving NET evolution is emerging. Indeed, mutations in genes encoding for proteins directly involved in chromatin remodelling, such as DAXX and ATRX are a frequent event in NET. Epigenetic changes are reversible and targetable; therefore, an attractive target for treatment. The discovery of the mechanisms underlying the epigenetic changes and the implication on gene and miRNA expression in the different subgroups of NET may represent a crucial change in the diagnosis of this disease, reveal new therapy targets and identify predictive markers. Molecular profiles derived from omics data including DNA mutation, methylation, gene and miRNA expression have already shown promising results in distinguishing clinically and molecularly different subtypes of NET. In this review, we recapitulate the major genetic and epigenetic characteristics of pancreatic, lung and small intestinal NET and the affected pathways. We also discuss potential epigenetic mechanisms leading to NET development. © 2017 Society for Endocrinology.

  19. Balancing Risk

    DEFF Research Database (Denmark)

    Nygaard, Lene; Rossen, Camilla Blach; Buus, Niels

    2015-01-01

    This study explored how eight pregnant women diagnosed with depression managed the decision whether or not to take antidepressants during pregnancy. In total, 11 interviews were conducted and analysed by means of constructivist grounded theory. The major category constructed was Balancing risk...

  20. Balancing Audio

    DEFF Research Database (Denmark)

    Walther-Hansen, Mads

    2016-01-01

    is not thoroughly understood. In this paper I treat balance as a metaphor that we use to reason about several different actions in music production, such as adjusting levels, editing the frequency spectrum or the spatiality of the recording. This study is based on an exploration of a linguistic corpus of sound...

  1. Activation of PAD4 in NET formation

    Directory of Open Access Journals (Sweden)

    Amanda eRohrbach

    2012-11-01

    Full Text Available Peptidyl arginine deiminases, or PADs, convert arginine residues to the non-ribosomally encoded amino acid citrulline in a variety of protein substrates. PAD4 is expressed in granulocytes and is essential for the formation of neutrophil extracellular traps (NETs via PAD4-mediated histone citrullination. Citrullination of histones is thought to promote NET formation by inducing chromatin decondensation and facilitating the expulsion of chromosomal DNA that is coated with antimicrobial molecules. Numerous stimuli have been reported to lead to PAD4 activation and NET formation. However, how this signaling process proceeds and how PAD4 becomes activated in cells is largely unknown. Herein, we describe the various stimuli and signaling pathways that have been implicated in PAD4 activation and NET formation, including the role of reactive oxygen species generation. To provide a foundation for the above discussion, we first describe PAD4 structure and function, and how these studies led to the development of PAD-specific inhibitors. A comprehensive survey of the receptors and signaling pathways that regulate PAD4 activation will be important for our understanding of innate immunity, and the identification of signaling intermediates in PAD4 activation may also lead to the generation of pharmaceuticals to target NET-related pathogenesis.

  2. Nitric oxide mediates root K+/Na+ balance in a mangrove plant, Kandelia obovata, by enhancing the expression of AKT1-type K+ channel and Na+/H+ antiporter under high salinity.

    Directory of Open Access Journals (Sweden)

    Juan Chen

    Full Text Available It is well known that nitric oxide (NO enhances salt tolerance of glycophytes. However, the effect of NO on modulating ionic balance in halophytes is not very clear. This study focuses on the role of NO in mediating K(+/Na(+ balance in a mangrove species, Kandelia obovata Sheue, Liu and Yong. We first analyzed the effects of sodium nitroprusside (SNP, an NO donor, on ion content and ion flux in the roots of K. obovata under high salinity. The results showed that 100 μM SNP significantly increased K(+ content and Na(+ efflux, but decreased Na(+ content and K(+ efflux. These effects of NO were reversed by specific NO synthesis inhibitor and scavenger, which confirmed the role of NO in retaining K(+ and reducing Na(+ in K. obovata roots. Using western-blot analysis, we found that NO increased the protein expression of plasma membrane (PM H(+-ATPase and vacuolar Na(+/H(+ antiporter, which were crucial proteins for ionic balance. To further clarify the molecular mechanism of NO-modulated K(+/Na(+ balance, partial cDNA fragments of inward-rectifying K(+ channel, PM Na(+/H(+ antiporter, PM H(+-ATPase, vacuolar Na(+/H(+ antiporter and vacuolar H(+-ATPase subunit c were isolated. Results of quantitative real-time PCR showed that NO increased the relative expression levels of these genes, while this increase was blocked by NO synthesis inhibitors and scavenger. Above results indicate that NO greatly contribute to K(+/Na(+ balance in high salinity-treated K. obovata roots, by activating AKT1-type K(+ channel and Na(+/H(+ antiporter, which are the critical components in K(+/Na(+ transport system.

  3. The Evolution of the Actin Binding NET Superfamily

    Directory of Open Access Journals (Sweden)

    Tim eHawkins

    2014-06-01

    Full Text Available The arabidopsis Networked protein superfamily are plant-specific actin binding proteins which specifically label different membrane compartments and identify specialized sites of interaction between actin and membranes unique to plants. There are 13 members of the superfamily in arabidopsis which group into 4 distinct clades or subfamilies. NET homologues are absent from the genomes of metazoa and fungi, furthermore in Plantae NET sequences are also absent from the genome of mosses and more ancient extant plant clades. A single subfamily of the NET proteins are found encoded in the club moss genome; an extant species of the earliest vascular plants. Gymnosperms have examples from subfamilies 4 and 3 with a hybrid form of NET1 and 2 which shows characteristics of both NET1 and NET2. In addition to NET3 and 4 subfamilies, the NET1 and pollen-expressed NET2 subfamilies are only found as independent sequences in angiosperms. This is consistent with the divergence of reproductive actin. The four subfamilies are conserved across monocots and eudicots with the numbers of members of each clade expanding at this point due in part to regions of genome duplication. Since the emergence of the NET superfamily at the dawn of vascular plants they have continued to develop and diversify in a manner which has mirrored the divergence and complexity of plant species through evolution in the ‘March of Progress’.

  4. Proof nets for lingusitic analysis

    NARCIS (Netherlands)

    Moot, R.C.A.

    2002-01-01

    This book investigates the possible linguistic applications of proof nets, redundancy free representations of proofs, which were introduced by Girard for linear logic. We will adapt the notion of proof net to allow the formulation of a proof net calculus which is soundand complete for the

  5. Teaching Tennis for Net Success.

    Science.gov (United States)

    Young, Bryce

    1989-01-01

    A program for teaching tennis to beginners, NET (Net Easy Teaching) is described. The program addresses three common needs shared by tennis students: active involvement in hitting the ball, clearing the net, and positive reinforcement. A sample lesson plan is included. (IAH)

  6. Net4Care Ecosystem Website

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak; Hansen, Klaus Marius; Rasmussen, Morten

    2012-01-01

    is a tele-monitoring scenario in which Net4Care clients are deployed in a gateway in private homes. Medical devices then connect to these gateways and transmit their observations to a Net4Care server. In turn the Net4Care server creates valid clinical HL7 documents, stores them in a national XDS repository...

  7. Load Matching and Grid Interaction of Net Zero Energy Buildings

    DEFF Research Database (Denmark)

    Voss, Karsten; Sartori, Igor; Napolitano, Assunta

    2010-01-01

    of seasonal energy storage on-site. Even though the wording “Net Zero Energy Building” focuses on the annual energy balance, large differences may occur between solution sets in the amount of grid interaction needed to reach the goal. The paper reports on the analysis of example buildings concerning the load...... matching and grid interaction. Indices to describe both issues are proposed and foreseen as part of a harmonized definition framework. The work is part of subtask A of the IEA SHCP Task40/ECBCS Annex 52: “Towards Net Zero Energy Solar Buildings”.......“Net Zero Energy Building” has become a prominent wording to describe the synergy of energy efficient building and renewable energy utilization to reach a balanced energy budget over a yearly cycle. Taking into account the energy exchange with a grid infrastructure overcomes the limitations...

  8. Expression

    Directory of Open Access Journals (Sweden)

    Wang-Xia Wang

    2014-02-01

    Full Text Available The miR-15/107 family comprises a group of 10 paralogous microRNAs (miRNAs, sharing a 5′ AGCAGC sequence. These miRNAs have overlapping targets. In order to characterize the expression of miR-15/107 family miRNAs, we employed customized TaqMan Low-Density micro-fluid PCR-array to investigate the expression of miR-15/107 family members, and other selected miRNAs, in 11 human tissues obtained at autopsy including the cerebral cortex, frontal cortex, primary visual cortex, thalamus, heart, lung, liver, kidney, spleen, stomach and skeletal muscle. miR-103, miR-195 and miR-497 were expressed at similar levels across various tissues, whereas miR-107 is enriched in brain samples. We also examined the expression patterns of evolutionarily conserved miR-15/107 miRNAs in three distinct primary rat brain cell preparations (enriched for cortical neurons, astrocytes and microglia, respectively. In primary cultures of rat brain cells, several members of the miR-15/107 family are enriched in neurons compared to other cell types in the central nervous system (CNS. In addition to mature miRNAs, we also examined the expression of precursors (pri-miRNAs. Our data suggested a generally poor correlation between the expression of mature miRNAs and their precursors. In summary, we provide a detailed study of the tissue and cell type-specific expression profile of this highly expressed and phylogenetically conserved family of miRNA genes.

  9. Greater expression of TLR2, TLR4, and IL6 due to negative energy balance is associated with lower expression of HLA-DRA and HLA-A in bovine blood neutrophils after intramammary mastitis challenge with Streptococcus uberis

    DEFF Research Database (Denmark)

    Moyes, Kasey; Drackley, James K; Morin, Dawn E

    2010-01-01

    Our objectives were to compare gene expression profiles in blood polymorphonuclear cells (PMN) during a Streptococcus uberis intramammary challenge between lactating cows subjected to feed restriction to induce negative energy balance (NEB; n = 5) and cows fed ad libitum to maintain positive ener...

  10. Master Robotic Net

    Directory of Open Access Journals (Sweden)

    Vladimir Lipunov

    2010-01-01

    Full Text Available The main goal of the MASTER-Net project is to produce a unique fast sky survey with all sky observed over a single night down to a limiting magnitude of 19-20. Such a survey will make it possible to address a number of fundamental problems: search for dark energy via the discovery and photometry of supernovae (including SNIa, search for exoplanets, microlensing effects, discovery of minor bodies in the Solar System, and space-junk monitoring. All MASTER telescopes can be guided by alerts, and we plan to observe prompt optical emission from gamma-ray bursts synchronously in several filters and in several polarization planes.

  11. Art/Net/Work

    DEFF Research Database (Denmark)

    Andersen, Christian Ulrik; Lindstrøm, Hanne

    2006-01-01

    The seminar Art|Net|Work deals with two important changes in our culture. On one side, the network has become essential in the latest technological development. The Internet has entered a new phase, Web 2.0, including the occurrence of as ‘Wiki’s’, ‘Peer-2-Peer’ distribution, user controlled...... the praxis of the artist. We see different kinds of interventions and activism (including ‘hacktivism’) using the network as a way of questioning the invisible rules that govern public and semi-public spaces. Who ‘owns’ them? What kind of social relationships do they generate? On what principle...

  12. Helminth.net: expansions to Nematode.net and an introduction to Trematode.net

    Science.gov (United States)

    Martin, John; Rosa, Bruce A.; Ozersky, Philip; Hallsworth-Pepin, Kymberlie; Zhang, Xu; Bhonagiri-Palsikar, Veena; Tyagi, Rahul; Wang, Qi; Choi, Young-Jun; Gao, Xin; McNulty, Samantha N.; Brindley, Paul J.; Mitreva, Makedonka

    2015-01-01

    Helminth.net (http://www.helminth.net) is the new moniker for a collection of databases: Nematode.net and Trematode.net. Within this collection we provide services and resources for parasitic roundworms (nematodes) and flatworms (trematodes), collectively known as helminths. For over a decade we have provided resources for studying nematodes via our veteran site Nematode.net (http://nematode.net). In this article, (i) we provide an update on the expansions of Nematode.net that hosts omics data from 84 species and provides advanced search tools to the broad scientific community so that data can be mined in a useful and user-friendly manner and (ii) we introduce Trematode.net, a site dedicated to the dissemination of data from flukes, flatworm parasites of the class Trematoda, phylum Platyhelminthes. Trematode.net is an independent component of Helminth.net and currently hosts data from 16 species, with information ranging from genomic, functional genomic data, enzymatic pathway utilization to microbiome changes associated with helminth infections. The databases’ interface, with a sophisticated query engine as a backbone, is intended to allow users to search for multi-factorial combinations of species’ omics properties. This report describes updates to Nematode.net since its last description in NAR, 2012, and also introduces and presents its new sibling site, Trematode.net. PMID:25392426

  13. NETS FOR PEACH PROTECTED CULTIVATION

    Directory of Open Access Journals (Sweden)

    Evelia Schettini

    2012-06-01

    Full Text Available The aim of this paper was to investigate the radiometric properties of coloured nets used to protect a peach cultivation. The modifications of the solar spectral distribution, mainly in the R and FR wavelength band, influence plant photomorphogenesis by means of the phytochrome and cryptochrome. The phytochrome response is characterized in terms of radiation rate in the red wavelengths (R, 600-700 nm to that in the farred radiation (FR, 700-800 nm, i.e. the R/FR ratio. The effects of the blue radiation (B, 400-500 nm is investigated by the ratio between the blue radiation and the far-red radiation, i.e. the B/FR ratio. A BLUE net, a RED net, a YELLOW net, a PEARL net, a GREY net and a NEUTRAL net were tested in Bari (Italy, latitude 41° 05’ N. Peach trees were located in pots inside the greenhouses and in open field. The growth of the trees cultivated in open field was lower in comparison to the growth of the trees grown under the nets. The RED, PEARL, YELLOW and GREY nets increased the growth of the trees more than the other nets. The nets positively influenced the fruit characteristics, such as fruit weight and flesh firmness.

  14. Mars MetNet Mission Status

    Science.gov (United States)

    Harri, Ari-Matti; Aleksashkin, Sergei; Arruego, Ignacio; Schmidt, Walter; Genzer, Maria; Vazquez, Luis; Haukka, Harri

    2015-04-01

    descent phase starting shortly after separation from the spacecraft. MetNet Mission payload instruments are specially designed to operate in very low power conditions. MNL flexible solar panels provides a total of approximately 0.7-0.8 W of electric power during the daylight time. As the provided power output is insufficient to operate all instruments simultaneously they are activated sequentially according to a specially designed cyclogram table which adapts itself to the different environmental constraints. 3. Mission Status Full Qualification Model (QM) of the MetNet landing unit with the Precursor Mission payload is currently under functional tests. In near future the QM unit will be exposed to environmental tests with qualification levels including vibrations, thermal balance, thermal cycling and mechanical impact shock. One complete flight unit of the entry, descent and landing systems (EDLS) has been manufactured and tested with acceptance levels. Another flight-like EDLS has been exposed to most of the qualification tests, and hence it may be used for flight after refurbishments. Accordingly two flight-capable EDLS systems exist. The eventual goal is to create a network of atmospheric observational posts around the Martian surface. Even if the MetNet mission is focused on the atmospheric science, the mission payload will also include additional kinds of geophysical instrumentation. The next step in the MetNet Precursor Mission to demonstrate the technical robustness and scientific capabilities of the MetNet type of landing vehicle. Definition of the Precursor Mission and discussions on launch opportunities are currently under way. The baseline program development funding exists for the next five years. Flight unit manufacture of the payload bay takes about 18 months, and it will be commenced after the Precursor Mission has been defined. References [1] http://metnet.fmi.fi

  15. Solar and Net Radiation for Estimating Potential Evaporation from Three Vegetation Canopies

    Science.gov (United States)

    D.M. Amatya; R.W. Skaggs; G.W. Cheschier; G.P. Fernandez

    2000-01-01

    Solar and net radiation data are frequent/y used in estimating potential evaporation (PE) from various vegetative surfaces needed for water balance and hydrologic modeling studies. Weather parameters such as air temperature, relative humidity, wind speed, solar radiation, and net radiation have been continuously monitored using automated sensors to estimate PE for...

  16. 47 CFR 32.4110 - Net current deferred nonoperating income taxes.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Net current deferred nonoperating income taxes... Sheet Accounts § 32.4110 Net current deferred nonoperating income taxes. (a) This account shall include the balance of income tax expense resulting from comprehensive interpreted tax allocation which has...

  17. The equivalency between logic Petri workflow nets and workflow nets.

    Science.gov (United States)

    Wang, Jing; Yu, ShuXia; Du, YuYue

    2015-01-01

    Logic Petri nets (LPNs) can describe and analyze batch processing functions and passing value indeterminacy in cooperative systems. Logic Petri workflow nets (LPWNs) are proposed based on LPNs in this paper. Process mining is regarded as an important bridge between modeling and analysis of data mining and business process. Workflow nets (WF-nets) are the extension to Petri nets (PNs), and have successfully been used to process mining. Some shortcomings cannot be avoided in process mining, such as duplicate tasks, invisible tasks, and the noise of logs. The online shop in electronic commerce in this paper is modeled to prove the equivalence between LPWNs and WF-nets, and advantages of LPWNs are presented.

  18. Differential regulation of perineuronal nets in the brain and spinal cord with exercise training.

    Science.gov (United States)

    Smith, Calvin C; Mauricio, Rui; Nobre, Luis; Marsh, Barnaby; Wüst, Rob C I; Rossiter, Harry B; Ichiyama, Ronaldo M

    2015-02-01

    Perineuronal nets (PNNs) are lattice like structures which encapsulate the cell body and proximal dendrites of many neurons and are thought to be involved in regulating synaptic plasticity. It is believed that exercise can enhance the plasticity of the Central Nervous System (CNS) in healthy and dysfunctional states by shifting the balance between plasticity promoting and plasticity inhibiting factors in favor of the former. Recent work has focused on exercise effects on trophic factors but its effect on other plasticity regulators is poorly understood. In the present study we investigated how exercise regulates PNN expression in the lumbar spinal cord and areas of the brain associated with motor control and learning and memory. Adult, female Sprague-Dawley rats with free access to a running wheel for 6 weeks had significantly increased PNN expression in the spinal cord compared to sedentary rats (PNN thickness around motoneurons, exercise=15.75±0.63μm, sedentary=7.98±1.29μm, pbrain associated with learning and memory there was a significant reduction in perineuronal net expression (number of neurons with PNN in hippocampus CA1-exercise 21±0.56 and sedentary 24±0.34, pexercised=2.37±0.13μm, sedentary=4.27±0.21μm; pexercise, PNNs are differentially regulated in select regions of the CNS, with a general decreased expression in the brain and increased expression in the lumbar spinal cord. This differential expression may indicate different regulatory mechanisms associated with plasticity in the brain compared to the spinal cord. Copyright © 2014 Elsevier Inc. All rights reserved.

  19. New method for electric equivalents synthesis expressed in digital filters form for transitory simulations in real time for great power nets; Novo metodo para sintese de equivalentes eletricos a filtros digitais para simulacao de transitorios em tempo real em redes eletricas de grande porte

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, Clever [Minas Gerais Univ., Belo Horizonte, MG (Brazil). Nucleo de Desenvolvimento Cientifico e Tecnologico em Descargas Atmosfericas]. E-mail: clever@cpdee.ufmg.br; Carneiro Junior, Sandoval [Universidade Federal, Rio de Janeiro, RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia; Szczupak, Jacques [Pontificia Univ. Catolica do Rio de Janeiro, RJ (Brazil)

    2001-07-01

    This article presents a new method to obtain subtransmission nets equivalents, expressed in form of digital filters of finite answer to the impulse, for transitory simulations in great power nets. Initially, it has been made considerations in the way of obtaining these filters, showing that they basically have been synthesized from the impedance and admittance functions of the secondary electric net to be processed in terms of equivalents in the domain of the w analogical frequency. It also is shown the transference technique to the time domain, in which it is used the z plane of the digital frequencies as an intermediate plane, being obtained from this way a set of equations susceptible of being implemented in program of transitory simulation in the time domain. The evaluation of this new method and evaluation of the reduction effect in the order of representative filters of the equivalents, are executed through the comparison of simulations which use the new technique together with other ones coming from EMTP. The obtained replies have demonstrated the effectiveness of the proposed method, opening new possibilities for transitory simulations in great power nets.

  20. Coloured Petri Nets

    DEFF Research Database (Denmark)

    Jensen, Kurt; Kristensen, Lars Michael

    studies that illustrate the practical use of CPN modelling and validation for design, specification, simulation, verification and implementation in various application domains. Their presentation primarily aims at readers interested in the practical use of CPN. Thus all concepts and constructs are first......Coloured Petri Nets (CPN) is a graphical language for modelling and validating concurrent and distributed systems, and other systems in which concurrency plays a major role. The development of such systems is particularly challenging because of inherent intricacies like possible nondeterminism...... and the immense number of possible execution sequences. In this textbook, Jensen and Kristensen introduce the constructs of the CPN modelling language and present the related analysis methods in detail. They also provide a comprehensive road map for the practical use of CPN by showcasing selected industrial case...

  1. Watt and joule balances

    Science.gov (United States)

    Robinson, Ian A.

    2014-04-01

    balance group are in the initial phases of the design and construction of a watt balance and their paper provides valuable information on the design that they are building. The design of the main magnet of a watt balance is critical to its successful operation, and an important assumption of watt balance operation is that the field of the magnet in moving mode is equivalent to that in weighing mode. Sutton and Clarkson from MSL describe a novel magnet which is designed to address this issue. The international prototype of the kilogram is kept in air but, after redefinition, the best realizations of the mass unit will be in vacuum. In their paper Berry and Davidson from NPL describe progress in techniques which relate mass measured in vacuum to that measured in air. Such techniques will be essential for making the results of watt and joule balance measurements available to science and industry. Both the NIST and NPL Mark II (NRC) watt balances use knife edges to act as the pivots for the beam. Knife edges suffer from hysteresis which can produce systematic offsets during weighing. In their paper Choi (KRISS) and Robinson (NPL) describe the analysis of this problem using both finite element (FEM) techniques and a stand-alone balance designed for testing knife edges. The last two papers deal with the possible future of the watt balance technique. The BIPM simultaneous measurement scheme for the watt balance was originally conceived for operation at cryogenic temperatures with a superconducting coil. In their paper de Mirandes and her co-authors describe initial work on the principles of this superconducting variant of the BIPM watt balance and concentrate on the characteristics of the superconducting coil in comparison with those of a normal coil. The final paper is a good example of serendipity in which Kibble (Independent Consultant) was designing novel watt balances based on seismometer suspensions and Robinson (NPL) had derived a set of general expressions, which are

  2. Zero Net Energy Myths and Modes of Thought

    Energy Technology Data Exchange (ETDEWEB)

    Rajkovich, Nicholas B.; Diamond, Rick; Burke, Bill

    2010-09-20

    The U.S. Department of Energy (DOE), the California Public Utilities Commission (CPUC), and a number of professional organizations have established a target of zero net energy (ZNE) in buildings by 2030. One definition of ZNE is a building with greatly reduced needs for energy through efficiency gains with the balance of energy needs supplied by renewable technologies. The push to ZNE is a response to research indicating that atmospheric concentrations of greenhouse gases have increased sharply since the eighteenth century, resulting in a gradual warming of the Earth?s climate. A review of ZNE policies reveals that the organizations involved frame the ZNE issue in diverse ways, resulting in a wide variety of myths and a divergent set of epistemologies. With federal and state money poised to promote ZNE, it is timely to investigate how epistemologies, meaning a belief system by which we take facts and convert them into knowledge upon which to take action, and the propagation of myths might affect the outcome of a ZNE program. This paper outlines myths commonly discussed in the energy efficiency and renewable energy communities related to ZNE and describes how each myth is a different way of expressing"the truth." The paper continues by reviewing a number of epistemologies common to energy planning, and concludes that the organizations involved in ZNE should work together to create a"collaborative rationality" for ZNE. Through this collaborative framework it is argued that we may be able to achieve the ZNE and greenhouse gas mitigation targets.

  3. NET23/STING Promotes Chromatin Compaction from the Nuclear Envelope

    Science.gov (United States)

    de las Heras, Jose I.; Saiz-Ros, Natalia; Makarov, Alexandr A.; Lazou, Vassiliki; Meinke, Peter; Waterfall, Martin; Kelly, David A.; Schirmer, Eric C.

    2014-01-01

    Changes in the peripheral distribution and amount of condensed chromatin are observed in a number of diseases linked to mutations in the lamin A protein of the nuclear envelope. We postulated that lamin A interactions with nuclear envelope transmembrane proteins (NETs) that affect chromatin structure might be altered in these diseases and so screened thirty-one NETs for those that promote chromatin compaction as determined by an increase in the number of chromatin clusters of high pixel intensity. One of these, NET23 (also called STING, MITA, MPYS, ERIS, Tmem173), strongly promoted chromatin compaction. A correlation between chromatin compaction and endogenous levels of NET23/STING was observed for a number of human cell lines, suggesting that NET23/STING may contribute generally to chromatin condensation. NET23/STING has separately been found to be involved in innate immune response signaling. Upon infection cells make a choice to either apoptose or to alter chromatin architecture to support focused expression of interferon genes and other response factors. We postulate that the chromatin compaction induced by NET23/STING may contribute to this choice because the cells expressing NET23/STING eventually apoptose, but the chromatin compaction effect is separate from this as the condensation was still observed when cells were treated with Z-VAD to block apoptosis. NET23/STING-induced compacted chromatin revealed changes in epigenetic marks including changes in histone methylation and acetylation. This indicates a previously uncharacterized nuclear role for NET23/STING potentially in both innate immune signaling and general chromatin architecture. PMID:25386906

  4. Reference Guide Microsoft.NET

    NARCIS (Netherlands)

    Zee M van der; Verspaij GJ; Rosbergen S; IMP; NMD

    2003-01-01

    Developers, administrators and managers can get more understanding of the .NET technology with this report. They can also make better choices how to use this technology. The report describes the results and conclusions of a study of the usability for the RIVM of this new generation .NET development

  5. Net neutrality and audiovisual services

    NARCIS (Netherlands)

    van Eijk, N.; Nikoltchev, S.

    2011-01-01

    Net neutrality is high on the European agenda. New regulations for the communication sector provide a legal framework for net neutrality and need to be implemented on both a European and a national level. The key element is not just about blocking or slowing down traffic across communication

  6. Long-term safety and stability of angiogenesis induced by balanced single-vector co-expression of PDGF-BB and VEGF164 in skeletal muscle

    Science.gov (United States)

    Gianni-Barrera, Roberto; Burger, Maximilian; Wolff, Thomas; Heberer, Michael; Schaefer, Dirk J.; Gürke, Lorenz; Mujagic, Edin; Banfi, Andrea

    2016-01-01

    Therapeutic angiogenesis by growth factor delivery is an attractive treatment strategy for ischemic diseases, yet clinical efficacy has been elusive. The angiogenic master regulator VEGF-A can induce aberrant angiogenesis if expressed above a threshold level. Since VEGF remains localized in the matrix around expressing cells, homogeneous dose distribution in target tissues is required, which is challenging. We found that co-expression of the pericyte-recruiting factor PDGF-BB at a fixed ratio with VEGF from a single bicistronic vector ensured normal angiogenesis despite heterogeneous high VEGF levels. Taking advantage of a highly controlled gene delivery platform, based on monoclonal populations of transduced myoblasts, in which every cell stably produces the same amount of each factor, here we rigorously investigated a) the dose-dependent effects, and b) the long-term safety and stability of VEGF and PDGF-BB co-expression in skeletal muscle. PDGF-BB co-expression did not affect the normal angiogenesis by low and medium VEGF doses, but specifically prevented vascular tumors by high VEGF, yielding instead normal and mature capillary networks, accompanied by robust arteriole formation. Induced angiogenesis persisted unchanged up to 4 months, while no tumors appeared. Therefore, PDGF-BB co-expression is an attractive strategy to improve safety and efficacy of therapeutic angiogenesis by VEGF gene delivery. PMID:26882992

  7. A Small Universal Petri Net

    Directory of Open Access Journals (Sweden)

    Dmitry A. Zaitsev

    2013-09-01

    Full Text Available A universal deterministic inhibitor Petri net with 14 places, 29 transitions and 138 arcs was constructed via simulation of Neary and Woods' weakly universal Turing machine with 2 states and 4 symbols; the total time complexity is exponential in the running time of their weak machine. To simulate the blank words of the weakly universal Turing machine, a couple of dedicated transitions insert their codes when reaching edges of the working zone. To complete a chain of a given Petri net encoding to be executed by the universal Petri net, a translation of a bi-tag system into a Turing machine was constructed. The constructed Petri net is universal in the standard sense; a weaker form of universality for Petri nets was not introduced in this work.

  8. High-level Petri Nets

    DEFF Research Database (Denmark)

    High-level Petri nets are now widely used in both theoretical analysis and practical modelling of concurrent systems. The main reason for the success of this class of net models is that they make it possible to obtain much more succinct and manageable descriptions than can be obtained by means...... of low-level Petri nets - while, on the other hand, they still offer a wide range of analysis methods and tools. The step from low-level nets to high-level nets can be compared to the step from assembly languages to modern programming languages with an elaborated type concept. In low-level nets...... there is only one kind of token and this means that the state of a place is described by an integer (and in many cases even by a boolean). In high-level nets each token can carry a complex information/data - which, e.g., may describe the entire state of a process or a data base. Today most practical...

  9. Pro asynchronous programming with .NET

    CERN Document Server

    Blewett, Richard; Ltd, Rock Solid Knowledge

    2014-01-01

    Pro Asynchronous Programming with .NET teaches the essential skill of asynchronous programming in .NET. It answers critical questions in .NET application development, such as: how do I keep my program responding at all times to keep my users happy how do I make the most of the available hardware how can I improve performanceIn the modern world, users expect more and more from their applications and devices, and multi-core hardware has the potential to provide it. But it takes carefully crafted code to turn that potential into responsive, scalable applications.With Pro Asynchronous Programming

  10. Conformal Nets II: Conformal Blocks

    Science.gov (United States)

    Bartels, Arthur; Douglas, Christopher L.; Henriques, André

    2017-08-01

    Conformal nets provide a mathematical formalism for conformal field theory. Associated to a conformal net with finite index, we give a construction of the `bundle of conformal blocks', a representation of the mapping class groupoid of closed topological surfaces into the category of finite-dimensional projective Hilbert spaces. We also construct infinite-dimensional spaces of conformal blocks for topological surfaces with smooth boundary. We prove that the conformal blocks satisfy a factorization formula for gluing surfaces along circles, and an analogous formula for gluing surfaces along intervals. We use this interval factorization property to give a new proof of the modularity of the category of representations of a conformal net.

  11. Net energy evaluation of feeds and determination of net energy requirements for pigs

    Directory of Open Access Journals (Sweden)

    Jean Noblet

    2007-07-01

    Full Text Available Feeds for pigs can be attributed different energy values according to, first, the step considered in energy utilization (DE: digestible energy, ME: metabolizable energy and NE: net energy and, second, the method used for estimation at each step. Reference methods for evaluating DE content are based on in vivo digestibility measurements; indirect estimates of DE values are obtained from in vitro methods or prediction equations based on chemical characteristics. Methods have also been proposed for estimating urinary energy (and gas energy to a smaller extent in order to calculate ME content from DE value. The NE values originate from energy balance studies (slaughter methods or, more commonly, indirect calorimetry measurements in respiration chambers and their compilation allows the calculation of NE prediction equations based on digestible nutrient contents or DE or ME contents. Such equations are applicable to both ingredients and compound feeds. They may differ between origins according to the fractionation method of organic matter or assumptions such as the NE requirement for maintenance (or fasting heat production. These measurements represent the bases for establishment of energy values in feeding tables. Results indicate that energy digestibility of feeds is negatively affected by dietary fibre content but this negative effect is attenuated with body weight increase, which suggests that feeds should be attributed DE values according to pig BW; in practice, at least two different DE values, one for growing-finishing pigs and one for mature pigs (reproductive sows, are recommended. The energy digestibility of pig feeds can also be affected by feed processing (pelletting, extrusion, etc.. Efficiency of ME utilization for NE averages 74-75% for conventional pig diets but it is directly dependent on diet chemical composition with efficiencies higher for ME from fat (90% or starch (82% than from protein or dietary fibre (60%. The hierarchy

  12. Increased trehalose biosynthesis in Hartig net hyphae of ectomycorrhizas.

    Science.gov (United States)

    López, Mónica Fajardo; Männer, Philipp; Willmann, Anita; Hampp, Rüdiger; Nehls, Uwe

    2007-01-01

    To obtain photoassimilates in ectomycorrhizal symbiosis, the fungus has to create a strong sink, for example, by conversion of plant-derived hexoses into fungus-specific compounds. Trehalose is present in large quantities in Amanita muscaria and may thus constitute an important carbon sink. In Amanita muscaria-poplar (Populus tremula x tremuloides) ectomycorrhizas, the transcript abundances of genes encoding key enzymes of fungal trehalose biosynthesis, namely trehalose-6-phosphate synthase (TPS), trehalose-6-phosphate phosphatase (TPP) and trehalose phosphorylase (TP), were increased. When mycorrhizas were separated into mantle and Hartig net, TPS, TPP and TP expression was specifically enhanced in Hartig net hyphae. Compared with the extraradical mycelium, TPS and TPP expression was only slightly increased in the fungal sheath, while the increase in the expression of TP was more pronounced. TPS enzyme activity was also elevated in Hartig net hyphae, displaying a direct correlation between transcript abundance and turnover rate. In accordance with enhanced gene expression and TPS activity, trehalose content was 2.7 times higher in the Hartig net. The enhanced trehalose biosynthesis at the plant-fungus interface indicates that trehalose is a relevant carbohydrate sink in symbiosis. As sugar and nitrogen supply affected gene expression only slightly, the strongly increased expression of the investigated genes in mycorrhizas is presumably developmentally regulated.

  13. Importance of energy balance in agriculture.

    Science.gov (United States)

    Meco, R.; Moreno, M. M.; Lacasta, C.; Tarquis, A. M.; Moreno, C.

    2012-04-01

    inputs) ones. Energy outputs (EO) are considered as the calorific value of the harvested biomass (main products and sub-products), calculated from the total production (kg/ha) and its corresponding energy coefficient (strongly correlated to the biochemical composition of the products). Based on energy inputs and outputs, energy efficiency can be expressed as (i) net energy produced (NE) (also known as energy gain or energy balance, calculated as EI-EO and expressed as MJ/ha), (ii) the energy output/input ratio (also known as energy efficiency and calculated as EO/EI), and (iii) energy productivity (EP) (Crop yield/EI, expressed as kg/MJ). Funding provided by Spanish Ministerio de Ciencia e Innovación (MICINN) through project no. AGL2010-21501/AGR is greatly appreciated.

  14. Petri Net Tool Overview 1986

    DEFF Research Database (Denmark)

    Jensen, Kurt; Feldbrugge, Frits

    1987-01-01

    This paper provides an overview of the characteristics of all currently available net based tools. It is a compilation of information provided by tool authors or contact persons. A concise one page overview is provided as well....

  15. PolicyNet Publication System

    Data.gov (United States)

    Social Security Administration — The PolicyNet Publication System project will merge the Oracle-based Policy Repository (POMS) and the SQL-Server CAMP system (MSOM) into a new system with an Oracle...

  16. KM3NeT

    CERN Multimedia

    KM3NeT is a large scale next-generation neutrino telescope located in the deep waters of the Mediterranean Sea, optimized for the discovery of galactic neutrino sources emitting in the TeV energy region.

  17. Net Neutrality: Background and Issues

    National Research Council Canada - National Science Library

    Gilroy, Angele A

    2006-01-01

    .... The move to place restrictions on the owners of the networks that compose and provide access to the Internet, to ensure equal access and nondiscriminatory treatment, is referred to as "net neutrality...

  18. Petri Nets in Cryptographic Protocols

    DEFF Research Database (Denmark)

    Crazzolara, Federico; Winskel, Glynn

    2001-01-01

    A process language for security protocols is presented together with a semantics in terms of sets of events. The denotation of process is a set of events, and as each event specifies a set of pre and postconditions, this denotation can be viewed as a Petri net. By means of an example we illustrate...... how the Petri-net semantics can be used to prove security properties....

  19. The Economics of Net Neutrality

    OpenAIRE

    Hahn, Robert W.; Wallsten, Scott

    2006-01-01

    This essay examines the economics of "net neutrality" and broadband Internet access. We argue that mandating net neutrality would be likely to reduce economic welfare. Instead, the government should focus on creating competition in the broadband market by liberalizing more spectrum and reducing entry barriers created by certain local regulations. In cases where a broadband provider can exercise market power the government should use its antitrust enforcement authority to police anticompetitiv...

  20. Mitigating the greenhouse gas balance of ruminant production systems through carbon sequestration in grasslands.

    Science.gov (United States)

    Soussana, J F; Tallec, T; Blanfort, V

    2010-03-01

    Soil carbon sequestration (enhanced sinks) is the mechanism responsible for most of the greenhouse gas (GHG) mitigation potential in the agriculture sector. Carbon sequestration in grasslands can be determined directly by measuring changes in soil organic carbon (SOC) stocks and indirectly by measuring the net balance of C fluxes. A literature search shows that grassland C sequestration reaches on average 5 ± 30 g C/m2 per year according to inventories of SOC stocks and -231 and 77 g C/m2 per year for drained organic and mineral soils, respectively, according to C flux balance. Off-site C sequestration occurs whenever more manure C is produced by than returned to a grassland plot. The sum of on- and off-site C sequestration reaches 129, 98 and 71 g C/m2 per year for grazed, cut and mixed European grasslands on mineral soils, respectively, however with high uncertainty. A range of management practices reduce C losses and increase C sequestration: (i) avoiding soil tillage and the conversion of grasslands to arable use, (ii) moderately intensifying nutrient-poor permanent grasslands, (iii) using light grazing instead of heavy grazing, (iv) increasing the duration of grass leys; (v) converting grass leys to grass-legume mixtures or to permanent grasslands. With nine European sites, direct emissions of N2O from soil and of CH4 from enteric fermentation at grazing, expressed in CO2 equivalents, compensated 10% and 34% of the on-site grassland C sequestration, respectively. Digestion inside the barn of the harvested herbage leads to further emissions of CH4 and N2O by the production systems, which were estimated at 130 g CO2 equivalents/m2 per year. The net balance of on- and off-site C sequestration, CH4 and N2O emissions reached 38 g CO2 equivalents/m2 per year, indicating a non-significant net sink activity. This net balance was, however, negative for intensively managed cut sites indicating a source to the atmosphere. In conclusion, this review confirms that

  1. Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8+ T Cell Responses to Chronic Viral Infections and Cancer

    Directory of Open Access Journals (Sweden)

    Isobel S. Okoye

    2017-09-01

    Full Text Available In cancer and chronic viral infections, T cells are exposed to persistent antigen stimulation. This results in expression of multiple inhibitory receptors also called “immune checkpoints” by T cells. Although these inhibitory receptors under normal conditions maintain self-tolerance and prevent immunopathology, their sustained expression deteriorates T cell function: a phenomenon called exhaustion. Recent advances in cancer immunotherapy involve blockade of cytotoxic T lymphocyte antigen-4 and programmed cell death 1 in order to reverse T cell exhaustion and reinvigorate immunity, which has translated to dramatic clinical remission in many cases of metastatic melanoma and lung cancer. With the paucity of therapeutic vaccines against chronic infections such as HIV, HPV, hepatitis B, and hepatitis C, such adjunct checkpoint blockade strategies are required including the blockade of other inhibitory receptors such as T cell immunoreceptor with immunoglobulin (Ig and immunoreceptor tyrosine-based inhibitory motif domains, T cell Ig and mucin-domain containing-3, lymphocyte activation gene 3, and V-domain Ig-containing suppressor of T cell activation. The nature of different chronic viral infections and cancers is likely to influence the level, composition, and pattern of inhibitory receptors expressed by responding T cells. This will have implications for checkpoint antibody blockade strategies employed for treating tumors and chronic viral infections. Here, we review recent advances that provide a clearer insight into the role of coinhibitory receptor expression in T cell exhaustion and reveal novel antibody-blockade therapeutic targets for chronic viral infections and cancer. Understanding the mechanism of T cell exhaustion in response to chronic virus infections and cancer as well as the nature of restored T cell responses will contribute to further improvement of immune checkpoint blockade strategies.

  2. Static and dynamic balance in young athletes

    OpenAIRE

    Ricotti, Leonardo

    2011-01-01

    The creation of a mature athlete necessarily passes through the expression of his potential during each phase of his development. Young athletes' trainers often neglect specific balance programs, above all in certain sports (e.g. soccer) where balance is poorly considered, but that is fundamental for the execution of complex technical movements, as well as for the prevention of future injuries. In this paper we highlight that balance training at specific ages is important for the maturation o...

  3. 26 CFR 1.904(f)-3 - Allocation of net operating losses and net capital losses.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Allocation of net operating losses and net....904(f)-3 Allocation of net operating losses and net capital losses. For rules relating to the allocation of net operating losses and net capital losses, see § 1.904(g)-3T. ...

  4. 29 CFR 4204.13 - Net income and net tangible assets tests.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Net income and net tangible assets tests. 4204.13 Section....13 Net income and net tangible assets tests. (a) General. The criteria under this section are that either— (1) Net income test. The purchaser's average net income after taxes for its three most recent...

  5. Regulation of Human Macrophage M1–M2 Polarization Balance by Hypoxia and the Triggering Receptor Expressed on Myeloid Cells-1

    Directory of Open Access Journals (Sweden)

    Federica Raggi

    2017-09-01

    Full Text Available Macrophages (Mf are a heterogeneous population of tissue-resident professional phagocytes and a major component of the leukocyte infiltrate at sites of inflammation, infection, and tumor growth. They can undergo diverse forms of activation in response to environmental factors, polarizing into specialized functional subsets. A common hallmark of the pathologic environment is represented by hypoxia. The impact of hypoxia on human Mf polarization has not been fully established. The objective of this study was to elucidate the effects of a hypoxic environment reflecting that occurring in vivo in diseased tissues on the ability of human Mf to polarize into classically activated (proinflammatory M1 and alternatively activated (anti-inflammatory M2 subsets. We present data showing that hypoxia hinders Mf polarization toward the M1 phenotype by decreasing the expression of T cell costimulatory molecules and chemokine homing receptors and the production of proinflammatory, Th1-priming cytokines typical of classical activation, while promoting their acquisition of phenotypic and secretory features of alternative activation. Furthermore, we identify the triggering receptor expressed on myeloid cells (TREM-1, a member of the Ig-like immunoregulatory receptor family, as a hypoxia-inducible gene in Mf and demonstrate that its engagement by an agonist Ab reverses the M2-polarizing effect of hypoxia imparting a M1-skewed phenotype to Mf. Finally, we provide evidence that Mf infiltrating the inflamed hypoxic joints of children affected by oligoarticular juvenile idiopatic arthritis express high surface levels of TREM-1 associated with predominant M1 polarization and suggest the potential of this molecule in driving M1 proinflammatory reprogramming in the hypoxic synovial environment.

  6. A more desirable balanced polyunsaturated fatty acid composition achieved by heterologous expression of Δ15/Δ4 desaturases in mammalian cells.

    Directory of Open Access Journals (Sweden)

    Guiming Zhu

    Full Text Available Arachidonic (ARA, eicosapentaenoic (EPA and docosahexaenoic (DHA acids are the most biologically active polyunsaturated fatty acids, but their biosyntheses in mammals are very limited. The biosynthesis of DHA is the most difficult, because this undergoes the Sprecher pathway--a further elongation step from docosapentaenoic acid (DPA, a Δ6-desaturase acting on a C24 fatty acid substrate followed by a peroxisomal chain shortening step. This paper reports the successful heterologous expression of two non-mammalian genes (with modification of codon usage, coding for Euglena gracilis Δ4-desaturase and Siganus canaliculatus Δ4-desaturase respectively, in mammalian cells (HEK293 cell line. Both of the Δ4-desaturases can efficiently function, directly converting DPA into DHA. Moreover, the cooperation of the E. gracilis Δ4-desaturase with C. elegans Δ15-desaturase (able to convert a number of n-6 PUFAs to their corresponding n-3 PUFAs in transgenic HEK293 cells made a more desirable fatty acid composition--a drastically reduced n-6/n-3 PUFAs ratio and a high level of DHA as well as EPA and ARA. Our findings provide a basis for potential applications of the gene constructs for expression of Δ15/Δ4-desaturases in transgenic livestock to produce such a fatty acid profile in the related products, which certainly will bring benefit to human health.

  7. Biodiversity offsets and the challenge of achieving no net loss.

    Science.gov (United States)

    Gardner, Toby A; VON Hase, Amrei; Brownlie, Susie; Ekstrom, Jonathan M M; Pilgrim, John D; Savy, Conrad E; Stephens, R T Theo; Treweek, Jo; Ussher, Graham T; Ward, Gerri; Ten Kate, Kerry

    2013-12-01

    Businesses, governments, and financial institutions are increasingly adopting a policy of no net loss of biodiversity for development activities. The goal of no net loss is intended to help relieve tension between conservation and development by enabling economic gains to be achieved without concomitant biodiversity losses. biodiversity offsets represent a necessary component of a much broader mitigation strategy for achieving no net loss following prior application of avoidance, minimization, and remediation measures. However, doubts have been raised about the appropriate use of biodiversity offsets. We examined what no net loss means as a desirable conservation outcome and reviewed the conditions that determine whether, and under what circumstances, biodiversity offsets can help achieve such a goal. We propose a conceptual framework to substitute the often ad hoc approaches evident in many biodiversity offset initiatives. The relevance of biodiversity offsets to no net loss rests on 2 fundamental premises. First, offsets are rarely adequate for achieving no net loss of biodiversity alone. Second, some development effects may be too difficult or risky, or even impossible, to offset. To help to deliver no net loss through biodiversity offsets, biodiversity gains must be comparable to losses, be in addition to conservation gains that may have occurred in absence of the offset, and be lasting and protected from risk of failure. Adherence to these conditions requires consideration of the wider landscape context of development and offset activities, timing of offset delivery, measurement of biodiversity, accounting procedures and rule sets used to calculate biodiversity losses and gains and guide offset design, and approaches to managing risk. Adoption of this framework will strengthen the potential for offsets to provide an ecologically defensible mechanism that can help reconcile conservation and development. Balances de Biodiversidad y el Reto de No Obtener P

  8. Compensatory regulation of acid-base balance during salinity transfer in rainbow trout (Oncorhynchus mykiss).

    Science.gov (United States)

    Gilmour, K M; Perry, S F; Esbaugh, A J; Genz, J; Taylor, J R; Grosell, M

    2012-02-01

    In seawater-acclimated rainbow trout (Oncorhynchus mykiss), base secretion into the intestine is a key component of the intestinal water absorption that offsets osmotic water loss to the marine environment. Acid-base balance is maintained by the matched excretion of acid equivalents via other routes, presumably the gill and/or kidney. The goal of the present study was to examine acid-base balance in rainbow trout upon transfer to more dilute environments, conditions under which base excretion into the intestine is predicted to fall, requiring compensatory adjustments of acid excretion at the gill and/or kidney if acid-base balance is to be maintained. Net acid excretion via the gill/kidney and rectal fluid, and blood acid-base status were monitored in seawater-acclimated rainbow trout maintained in seawater or transferred to iso-osmotic conditions. As predicted, transfer to iso-osmotic conditions significantly reduced base excretion into the rectal fluid (by ~48%). Transfer to iso-osmotic conditions also significantly reduced the excretion of titratable acidity via extra-intestinal routes from 183.4 ± 71.3 to -217.5 ± 42.7 μmol kg(-1) h(-1) (N = 7). At the same time, however, ammonia excretion increased significantly during iso-osmotic transfer (by ~72%) so that the apparent overall reduction in net acid excretion (from 419.7 ± 92.9 to 189.2 ± 76.5 μmol kg(-1 )h(-1); N = 7) was not significant. Trout maintained blood acid-base status during iso-osmotic transfer, although arterial pH was significantly higher in transferred fish than in those maintained in seawater. To explore the mechanisms underlying these adjustments of acid-base regulation, the relative mRNA expression and where possible, activity of a suite of proteins involved in acid-base balance were examined in intestine, gill and kidney. At the kidney, reduced mRNA expression of carbonic anhydrase (CA; cytosolic and membrane-associated CA IV), V-type H(+)-ATPase, and Na(+)/HCO(3) (-) co

  9. TimeNET Optimization Environment

    Directory of Open Access Journals (Sweden)

    Christoph Bodenstein

    2015-12-01

    Full Text Available In this paper a novel tool for simulation-based optimization and design-space exploration of Stochastic Colored Petri nets (SCPN is introduced. The working title of this tool is TimeNET Optimization Environment (TOE. Targeted users of this tool are people modeling complex systems with SCPNs in TimeNET who want to find parameter sets that are optimal for a certain performance measure (fitness function. It allows users to create and simulate sets of SCPNs and to run different optimization algorithms based on parameter variation. The development of this tool was motivated by the need to automate and speed up tests of heuristic optimization algorithms to be applied for SCPN optimization. A result caching mechanism is used to avoid recalculations.

  10. Late-onset running biphasically improves redox balance, energy- and methylglyoxal-related status, as well as SIRT1 expression in mouse hippocampus.

    Directory of Open Access Journals (Sweden)

    Stefano Falone

    Full Text Available Despite the active research in this field, molecular mechanisms underlying exercise-induced beneficial effects on brain physiology and functions are still matter of debate, especially with regard to biological processes activated by regular exercise affecting the onset and progression of hippocampal aging in individuals unfamiliar with habitual physical activity. Since such responses seem to be mediated by changes in antioxidative, antiglycative and metabolic status, a possible exercise-induced coordinated response involving redox, methylglyoxal- and sirtuin-related molecular networks may be hypothesized. In this study, hippocampi of CD1 mice undergoing the transition from mature to middle age were analyzed for redox-related profile, oxidative and methylglyoxal-dependent damage patterns, energy metabolism, sirtuin1 and glyoxalase1 expression after a 2- or 4-mo treadmill running program. Our findings suggested that the 4-mo regular running lowered the chance of dicarbonyl and oxidative stress, activated mitochondrial catabolism and preserved sirtuin1-related neuroprotection. Surprisingly, the same cellular pathways were negatively affected by the first 2 months of exercise, thus showing an interesting biphasic response. In conclusion, the duration of exercise caused a profound shift in the response to regular running within the rodent hippocampus in a time-dependent fashion. This research revealed important details of the interaction between exercise and mammal hippocampus during the transition from mature to middle age, and this might help to develop non-pharmacological approaches aimed at retarding brain senescence, even in individuals unfamiliar with habitual exercise.

  11. Implementing NetScaler VPX

    CERN Document Server

    Sandbu, Marius

    2014-01-01

    An easy-to-follow guide with detailed step-by step-instructions on how to implement the different key components in NetScaler, with real-world examples and sample scenarios.If you are a Citrix or network administrator who needs to implement NetScaler in your virtual environment to gain an insight on its functionality, this book is ideal for you. A basic understanding of networking and familiarity with some of the different Citrix products such as XenApp or XenDesktop is a prerequisite.

  12. Net4Care PHMR Library

    DEFF Research Database (Denmark)

    2014-01-01

    The Net4Care PHMR library contains a) A GreenCDA approach for constructing a data object representing a PHMR document: SimpleClinicalDocument, and b) A Builder which can produce a XML document representing a valid Danish PHMR (following the MedCom profile) document from the SimpleClinicalDocument......The Net4Care PHMR library contains a) A GreenCDA approach for constructing a data object representing a PHMR document: SimpleClinicalDocument, and b) A Builder which can produce a XML document representing a valid Danish PHMR (following the MedCom profile) document from the Simple...

  13. Hierarchies in Coloured Petri Nets

    DEFF Research Database (Denmark)

    Huber, Peter; Jensen, Kurt; Shapiro, Robert M.

    1991-01-01

    The paper shows how to extend Coloured Petri Nets with a hierarchy concept. The paper proposes five different hierarchy constructs, which allow the analyst to structure large CP-nets as a set of interrelated subnets (called pages). The paper discusses the properties of the proposed hierarchy...... constructs, and it illustrates them by means of two examples. The hierarchy constructs can be used for theoretical considerations, but their main use is to describe and analyse large real-world systems. All of the hierarchy constructs are supported by the editing and analysis facilities in the CPN Palette...

  14. A functional and transcriptomic analysis of NET1 bioactivity in gastric cancer

    LENUS (Irish Health Repository)

    Bennett, Gayle

    2011-02-01

    Abstract Background NET1, a RhoA guanine exchange factor, is up-regulated in gastric cancer (GC) tissue and drives the invasive phenotype of this disease. In this study, we aimed to determine the role of NET1 in GC by monitoring the proliferation, motility and invasion of GC cells in which NET1 has been stably knocked down. Additionally, we aimed to determine NET1-dependent transcriptomic events that occur in GC. Methods An in vitro model of stable knockdown of NET1 was achieved in AGS human gastric adenocarcinoma cells via lentiviral mediated transduction of short-hairpin (sh) RNA targeting NET1. Knockdown was assessed using quantitative PCR. Cell proliferation was assessed using an MTS assay and cell migration was assessed using a wound healing scratch assay. Cell invasion was assessed using a transwell matrigel invasion assay. Gene expression profiles were examined using affymetrix oligonucleotide U133A expression arrays. A student\\'s t test was used to determine changes of statistical significance. Results GC cells were transduced with NET1 shRNA resulting in a 97% reduction in NET1 mRNA (p < 0.0001). NET1 knockdown significantly reduced the invasion and migration of GC cells by 94% (p < 0.05) and 24% (p < 0.001) respectively, while cell proliferation was not significantly altered following NET1 knockdown. Microarray analysis was performed on non-target and knockdown cell lines, treated with and without 10 μM lysophosphatidic acid (LPA) allowing us to identify NET1-dependent, LPA-dependent and NET1-mediated LPA-induced gene transcription. Differential gene expression was confirmed by quantitative PCR. Shortlisted NET1-dependent genes included STAT1, TSPAN1, TGFBi and CCL5 all of which were downregulatd upon NET1 downregulation. Shortlisted LPA-dependent genes included EGFR and PPARD where EGFR was upregulated and PPARD was downregulated upon LPA stimulation. Shortlisted NET1 and LPA dependent genes included IGFR1 and PIP5K3. These LPA induced genes were

  15. A Petri Net Definition of a System Description Language

    DEFF Research Database (Denmark)

    Jensen, Kurt; Kyng, Morten; Madsen, Ole Lehrmann

    1979-01-01

    This paper introduces a language for the description of systems with concurrency, and presents a formal definition of its semantics. The language is based on Delta and the semantic model is an extension of Petri nets with a data part and with expressions attached to transitions and to places....

  16. D.NET case study

    International Development Research Centre (IDRC) Digital Library (Canada)

    lremy

    developing products, marketing tools and building capacity of the grass root telecentre workers. D.Net recognized that it had several ideas worth developing into small interventions that would make big differences, but resource constraints were a barrier for scaling-up these initiatives. More demands, limited resources.

  17. Surgery for GEP-NETs

    DEFF Research Database (Denmark)

    Knigge, Ulrich; Hansen, Carsten Palnæs

    2012-01-01

    Surgery is the only treatment that may cure the patient with gastroentero-pancreatic (GEP) neuroendocrine tumours (NET) and neuroendocrine carcinomas (NEC) and should always be considered as first line treatment if R0/R1 resection can be achieved. The surgical and interventional procedures for GEP...

  18. Net Neutrality in the Netherlands

    NARCIS (Netherlands)

    van Eijk, N.

    2014-01-01

    The Netherlands is among the first countries that have put specific net neutrality standards in place. The decision to implement specific regulation was influenced by at least three factors. The first was the prevailing social and academic debate, partly due to developments in the United States. The

  19. Complexity Metrics for Workflow Nets

    DEFF Research Database (Denmark)

    Lassen, Kristian Bisgaard; van der Aalst, Wil M.P.

    2009-01-01

    Process modeling languages such as EPCs, BPMN, flow charts, UML activity diagrams, Petri nets, etc.\\ are used to model business processes and to configure process-aware information systems. It is known that users have problems understanding these diagrams. In fact, even process engineers and system...

  20. Testing direct and interactive effects of tree size, stand competition, water balance, heat, and freezing on probability of mortality

    Science.gov (United States)

    Hember, R. A.; Kurz, W. A.; Coops, N. C.

    2016-12-01

    Water stress affects rates of tree mortality in diverse ways. In a previous study, we included standardized water-balance variables as predictors in conventional models of individual-tree mortality drawing on over 8 million observations for 64 North American tree species. We found that probability of tree mortality (Pm) was related to soil-water content (Ws) and/or reference evapotranspiration (ETref) in over 90 percent of the species samples and that sensitivity to water-balance variables was typically mediated by tree height (h) and aridity class (AC) of the site. Here we expand on the model-building exercise to test the additional hypotheses that: (1) sensitivity of Pm of short trees to water-balance variables increases with stand-level biomass of larger trees (BLS) due to competition among trees for access to soil water; (2) sensitivity of Pm to water-balance variables increases with temperature (T) due either to higher respiration or error in the expression of ETref and (3) sensitivity of Pm to water-balance variables increases with the number of days with frost (DWF) due to decreasing hydraulic conductance associated either with occurrence or avoidance of freezing-induced embolism. We describe whether the hypotheses are supported and how the modifications influence predictions of net ecosystem biomass production (NEBP) of North American forests over 1951-2014.

  1. The Impact of Trade Balance in the Current Account of Kosovo’s Balance of Payments

    OpenAIRE

    Safet Merovci; Edona Sekiraça

    2014-01-01

    The trade deficit and specifically the current account deficit are the main challenges that Kosovo‘s economy is facing. According to the Balance of Payments Statistics (BOP), the trade balance of goods is the largest component, expressed in absolute and relative terms and consequently it determines the behavior of the current account balance. Trade deficit to GDP ratio is very high - more than 50 percent. Regarding this, financing the constant deficit of the current account is ...

  2. Army Net Zero Prove Out. Army Net Zero Training Report

    Science.gov (United States)

    2014-11-20

    sensors were strategically placed throughout the installation by magnetically attaching them to water main valve stems. The sensors check sound...Recycle Wrap  Substitutes for Packaging Materials  Re-Use of Textiles and Linens  Setting Printers to Double-Sided Printing Net Zero Waste...can effectively achieve source reduction. Clean and Re-Use Shop Rags - Shop rags represent a large textile waste stream at many installations. As a

  3. Army Net Zero Prove Out. Net Zero Waste Best Practices

    Science.gov (United States)

    2014-11-20

    Anaerobic Digesters – Although anaerobic digestion is not a new technology and has been used on a large-scale basis in wastewater treatment , the...technology and has been used on a large-scale basis in wastewater treatment , the use of the technology should be demonstrated with other...approaches can be used for cardboard and cellulose -based packaging materials. This approach is in line with the Net Zero Waste hierarchy in terms of

  4. Effects of Ischemic Acute Kidney Injury on Lung Water Balance: Nephrogenic Pulmonary Edema?

    Directory of Open Access Journals (Sweden)

    Rajit K. Basu

    2011-01-01

    Full Text Available Pulmonary edema worsens the morbidity and increases the mortality of critically ill patients. Mechanistically, edema formation in the lung is a result of net flow across the alveolar capillary membrane, dependent on the relationship of hydrostatic and oncotic pressures. Traditionally, the contribution of acute kidney injury (AKI to the formation of pulmonary edema has been attributed to bulk fluid accumulation, increasing capillary hydrostatic pressure and the gradient favoring net flow into the alveolar spaces. Recent research has revealed more subtle, and distant, effects of AKI. In this review we discuss the concept of nephrogenic pulmonary edema. Pro-inflammatory gene upregulation, chemokine over-expression, altered biochemical channel function, and apoptotic dysregulation manifest in the lung are now understood as “extra-renal” and pulmonary effects of AKI. AKI should be counted as a disease process that alters the endothelial integrity of the alveolar capillary barrier and has the potential to overpower the ability of the lung to regulate fluid balance. Nephrogenic pulmonary edema, therefore, is the net effect of fluid accumulation in the lung as a result of both the macroscopic and microscopic effects of AKI.

  5. Possibilistic Fuzzy Net Present Value Model and Application

    Directory of Open Access Journals (Sweden)

    S. S. Appadoo

    2014-01-01

    Full Text Available The cash flow values and the interest rate in the net present value (NPV model are usually specified by either crisp numbers or random variables. In this paper, we first discuss some of the recent developments in possibility theory and find closed form expressions for fuzzy possibilistic net present value (FNPV. Then, following Carlsson and Fullér (2001, we discuss some of the possibilistic moments related to FNPV model along with an illustrative numerical example. We also give a unified approach to find higher order moments of FNPV by using the moment generating function introduced by Paseka et al. (2011.

  6. EQUILIBRIUM ANALYSIS OF FINANCIAL COMPANY BASED ON INFORMATION PROVIDED BY THE BALANCE SHEET

    Directory of Open Access Journals (Sweden)

    Ștefăniță ȘUȘU

    2014-06-01

    Full Text Available This article highlights the importance of indicators (as net working capital, working capital requirements and net cash by means of which it is considered in the context of financial balances capitalization information released by the balance sheet of an entity tourist profile. Theoretical concepts presented in a logical sequence are combined with the practical example transposed Turism Covasna company. The results of the analysis are interpreted while trying to formulate solutions to the economic and financial viability of the entity.

  7. Mass Balance of the Ward Hunt Ice Rise and Ice Shelf: A 10 Year Record,

    Science.gov (United States)

    The results of 10 years’ (1958-68) record of accumulation and ablation from the Ward Hunt ice rise and of 3 years’ (1965-68) record from the Ward... Hunt Ice Shelf are presented. The net mass balances on the ice rise for the 3 years 1962-65 are positive, while the net mass balances measured in the other years on both ice rise and ice shelf are all negative. (Author)

  8. Towards new information resources for public health--from WordNet to MedicalWordNet.

    Science.gov (United States)

    Fellbaum, Christiane; Hahn, Udo; Smith, Barry

    2006-06-01

    In the last two decades, WordNet has evolved as the most comprehensive computational lexicon of general English. In this article, we discuss its potential for supporting the creation of an entirely new kind of information resource for public health, viz. MedicalWordNet. This resource is not to be conceived merely as a lexical extension of the original WordNet to medical terminology; indeed, there is already a considerable degree of overlap between WordNet and the vocabulary of medicine. Instead, we propose a new type of repository, consisting of three large collections of (1) medically relevant word forms, structured along the lines of the existing Princeton WordNet; (2) medically validated propositions, referred to here as medical facts, which will constitute what we shall call MedicalFactNet; and (3) propositions reflecting laypersons' medical beliefs, which will constitute what we shall call the MedicalBeliefNet. We introduce a methodology for setting up the MedicalWordNet. We then turn to the discussion of research challenges that have to be met to build this new type of information resource. We build a database of sentences relevant to the medical domain. The sentences are generated from WordNet via its relations as well as from medical statements broken down into elementary propositions. Two subcorpora of sentences are distinguished, MedicalBeliefNet and MedicalFactNet. The former is rated for assent by laypersons; the latter for correctness by medical experts. The sentence corpora will be valuable for a variety of applications in information retrieval as well as in research in linguistics and psychology with respect to the study of expert and non-expert beliefs and their linguistic expressions. Our work has to meet several considerable challenges. These include accounting for the distinction between medical experts and laypersons, the social issues of expert-layperson communication in different media, the linguistic aspects of encoding medical knowledge, and

  9. HANPP Collection: Human Appropriation of Net Primary Productivity as a Percentage of Net Primary Productivity

    Data.gov (United States)

    National Aeronautics and Space Administration — The Human Appropriation of Net Primary Productivity (HANPP) as a Percentage of Net Primary Productivity (NPP) portion of the Human Appropriation of Net Primary...

  10. Hydrodynamic characteristics of plane netting used for aquaculture net cages in uniform current

    National Research Council Canada - National Science Library

    DONG, SHUCHUANG; HU, FUXIANG; KUMAZAWA, TAISEI; SIODE, DAISUKE; TOKAI, TADASHI

    2016-01-01

      The hydrodynamic characteristics of polyethylene (PE) netting and chain link wire netting with different types of twine diameter and mesh size for aquaculture net cages were examined by experiments in a flume tank...

  11. From deficit to surplus: An econometric analysis of US trade balance in forest products

    Science.gov (United States)

    Daowei Zhang; Ying Lin; Jeffrey P. Prestemon

    2017-01-01

    Although the US trade deficit has persisted since 1975, the country changed in 2009 from a net importer to a net exporter of forest products, emerging as the world's largest exporter of forest products. Drawing on recent data, we model the real dollar value of US exports, imports, and the trade balance in forest products to identify factors likely to explain this...

  12. Isolated unit tests in .Net

    OpenAIRE

    Haukilehto, Tero

    2013-01-01

    In this thesis isolation in unit testing is studied to get a precise picture of the isolation frameworks available for .Net environment. At the beginning testing is discussed in theory with the benefits and the problems it may have been linked with. The theory includes software development in general in connection with testing. Theory of isolation is also described before the actual isolation frameworks are represented. Common frameworks are described in more detail and comparable informa...

  13. Balance Food and Activity

    Science.gov (United States)

    ... News Features Spokespeople News Archive eNewsletters Calendar Balance Food and Activity What is Energy Balance? Energy is ... of calories just by breathing air and digesting food. You also burn a certain number of calories ( ...

  14. Balanced Scorecard voor inkoop

    NARCIS (Netherlands)

    van der Honing, R.; Schotanus, Fredo

    2003-01-01

    Een Balanced Scorecard kan ontwikkeld worden voor de hele organisatie, maar ook voor onderdelen daarvan. In dit artikel wordt ingegaan op de ontwikkeling van een Balanced Scorecard voor de inkoopafdeling

  15. An Efficient Translation of Timed-Arc Petri Nets to Networks of Timed Automata

    DEFF Research Database (Denmark)

    Byg, Joakim; Jørgensen, Kenneth Yrke; Srba, Jiri

    2009-01-01

    to enforce urgency and with transport arcs to generalise the read-arcs. We also describe a novel translation from the extended timed-arc Petri net model to networks of timed automata. The translation is implemented in the tool TAPAAL and it uses UPPAAL as the verification engine. Our experiments confirm......Bounded timed-arc Petri nets with read-arcs were recently proven equivalent to networks of timed automata, though the Petri net model cannot express urgent behaviour and the described mutual trans- lations are rather inefficient. We propose an extension of timed-arc Petri nets with invariants...

  16. Fluid and Electrolyte Balance

    Science.gov (United States)

    ... Balance the amount of water in your body Balance your body's acid/base (pH) level Move nutrients into your cells Move wastes out of your cells Make sure that your nerves, muscles, the ... something upsets this balance, you may have too little water (dehydration) or ...

  17. Waterscape determinants of net mercury methylation in a tropical wetland.

    Science.gov (United States)

    Lázaro, Wilkinson L; Díez, Sergi; da Silva, Carolina J; Ignácio, Áurea R A; Guimarães, Jean R D

    2016-10-01

    The periphyton associated with freshwater macrophyte roots is the main site of Hg methylation in different wetland environments in the world. The aim of this study was to test the use of connectivity metrics of water bodies, in the context of patches, in a tropical waterscape wetland (Guapore River, Amazonia, Brazil) as a predictor of potential net methylmercury (MeHg) production by periphyton communities. We sampled 15 lakes with different patterns of lateral connectivity with the main river channel, performing net mercury methylation potential tests in incubations with local water and Eichhornia crassipes root-periphyton samples, using (203)HgCl2 as a tracer. Physico-chemical variables, landscape data (morphological characteristics, land use, and lateral connection type of water bodies) using GIS resources and field data were analyzed with Generalized Additive Models (GAM). The net Me(203)Hg production (as % of total added (203)Hg) was expressive (6.2-25.6%) showing that periphyton is an important matrix in MeHg production. The model that best explained the variation in the net Me(203)Hg production (76%) was built by the variables: connection type, total phosphorus and dissolved organic carbon (DOC) in water (AICc=48.324, p=0.001). Connection type factor was the best factor to model fit (r(2)=0.32; p=0.008) and temporarily connected lakes had higher rates of net mercury methylation. Both DOC and total phosphorus showed positive significant covariation with the net methylation rates (r(2)=0.26; p=0.008 and r(2)=0.21; p=0.012 respectively). Our study suggests a strong relationship between rates of net MeHg production in this tropical area and the type of water body and its hydrological connectivity within the waterscape. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. Event hierarchies in DanNet

    DEFF Research Database (Denmark)

    Pedersen, Bolette Sandford; Nimb, Sanni

    2008-01-01

    Artiklen omhandler udarbejdelsen af et verbumshierarki i det leksikalsk-semantiske ordnet, DanNet.......Artiklen omhandler udarbejdelsen af et verbumshierarki i det leksikalsk-semantiske ordnet, DanNet....

  19. The Uniframe .Net Web Service Discovery Service

    National Research Council Canada - National Science Library

    Berbeco, Robert W

    2003-01-01

    Microsoft .NET allows the creation of distributed systems in a seamless manner Within NET small, discrete applications, referred to as Web services, are utilized to connect to each other or larger applications...

  20. Long Term RadNet Quality Data

    Data.gov (United States)

    U.S. Environmental Protection Agency — This RadNet Quality Data Asset includes all data since initiation and when ERAMS was expanded to become RadNet, name changed to reflect new mission. This includes...

  1. Development of Network Interface Cards for TRIDAQ systems with the NaNet framework

    Science.gov (United States)

    Ammendola, R.; Biagioni, A.; Cretaro, P.; Di Lorenzo, S.; Fiorini, M.; Frezza, O.; Lamanna, G.; Lo Cicero, F.; Lonardo, A.; Martinelli, M.; Neri, I.; Paolucci, P. S.; Pastorelli, E.; Piandani, R.; Pontisso, L.; Rossetti, D.; Simula, F.; Sozzi, M.; Valente, P.; Vicini, P.

    2017-03-01

    NaNet is a framework for the development of FPGA-based PCI Express (PCIe) Network Interface Cards (NICs) with real-time data transport architecture that can be effectively employed in TRIDAQ systems. Key features of the architecture are the flexibility in the configuration of the number and kind of the I/O channels, the hardware offloading of the network protocol stack, the stream processing capability, and the zero-copy CPU and GPU Remote Direct Memory Access (RDMA). Three NIC designs have been developed with the NaNet framework: NaNet-1 and NaNet-10 for the CERN NA62 low level trigger and NaNet3 for the KM3NeT-IT underwater neutrino telescope DAQ system. We will focus our description on the NaNet-10 design, as it is the most complete of the three in terms of capabilities and integrated IPs of the framework.

  2. PsychoNet: a psycholinguistc commonsense ontology

    OpenAIRE

    Mohtasseb, Haytham; Ahmed, Amr

    2010-01-01

    Ontologies have been widely accepted as the most advanced knowledge representation model. This paper introduces PsychoNet, a new knowledgebase that forms the link between psycholinguistic taxonomy, existing in LIWC, and its semantic textual representation in the form of commonsense semantic ontology, represented by ConceptNet. The integration of LIWC and ConceptNet and the added functionalities facilitate employing ConceptNet in psycholinguistic studies. Furthermore, it simplifies utilization...

  3. Salt balance, fresh water residence time and budget for non ...

    African Journals Online (AJOL)

    Water and salt budgets suggest that in order to balance the inflow and outflow of water at Makoba bay, there is net flux of water from the bay to the open ocean during wet season. Residual salt fluxes between the bay and the open ocean indicate advective salt export. Exchange of water between the bay with the open ocean ...

  4. Relationships between net primary productivity and forest stand age in U.S. forests

    Science.gov (United States)

    Liming He; Jing M. Chen; Yude Pan; Richard Birdsey; Jens. Kattge

    2012-01-01

    Net primary productivity (NPP) is a key flux in the terrestrial ecosystem carbon balance, as it summarizes the autotrophic input into the system. Forest NPP varies predictably with stand age, and quantitative information on the NPP-age relationship for different regions and forest types is therefore fundamentally important for forest carbon cycle modeling. We used four...

  5. Gap filling strategies for defensible annual sums of net ecosystem exchange

    NARCIS (Netherlands)

    Falge, E.; Baldocchi, D.; Olson, R.; Anthoni, P.; Aubinet, M.; Bernhofer, C.; Burba, G.; Ceulemans, R.; Clement, R.; Dolman, H.; Granier, A.; Gross, P.; Grünwald, T.; Hollinger, D.; Jensen, N.O.; Katul, G.; Keronen, P.; Kowalski, A.; Lai, C.T.; Law, B.E.; Meyers, T.; Moncrieff, J.; Moors, E.J.; Munger, J.W.; Pilegaard, K.; Rebmann, C.; Suyker, A.; Tenhunen, J.; Tu, K.

    2001-01-01

    Heightened awareness of global change issues within both science and political communities has increased interest in using the global network of eddy covariance flux towers to more fully understand the impacts of natural and anthropogenic phenomena on the global carbon balance. Comparisons of net

  6. 78 FR 72451 - Net Investment Income Tax

    Science.gov (United States)

    2013-12-02

    ... Revenue Service 26 CFR Part 1 RIN 1545-BL74 Net Investment Income Tax AGENCY: Internal Revenue Service...). These regulations provide guidance on the computation of net investment income. The regulations affect... lesser of: (A) The individual's net investment income for such taxable year, or (B) the excess (if any...

  7. 47 CFR 69.302 - Net investment.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Net investment. 69.302 Section 69.302... Apportionment of Net Investment § 69.302 Net investment. (a) Investment in Accounts 2001, 1220 and Class B Rural...) Investment in Accounts 2002, 2003 and to the extent such inclusions are allowed by this Commission, Account...

  8. 47 CFR 65.450 - Net income.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Net income. 65.450 Section 65.450... OF RETURN PRESCRIPTION PROCEDURES AND METHODOLOGIES Exchange Carriers § 65.450 Net income. (a) Net income shall consist of all revenues derived from the provision of interstate telecommunications services...

  9. 47 CFR 65.500 - Net income.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Net income. 65.500 Section 65.500... OF RETURN PRESCRIPTION PROCEDURES AND METHODOLOGIES Interexchange Carriers § 65.500 Net income. The net income methodology specified in § 65.450 shall be utilized by all interexchange carriers that are...

  10. NetBeans IDE 8 cookbook

    CERN Document Server

    Salter, David

    2014-01-01

    If you're a Java developer of any level using NetBeans and want to learn how to get the most out of NetBeans, then this book is for you. Learning how to utilize NetBeans will provide a firm foundation for your Java application development.

  11. Characterizing behavioural congruences for Petri nets

    DEFF Research Database (Denmark)

    Nielsen, Mogens; Priese, Lutz; Sassone, Vladimiro

    1995-01-01

    We exploit a notion of interface for Petri nets in order to design a set of net combinators. For such a calculus of nets, we focus on the behavioural congruences arising from four simple notions of behaviour, viz., traces, maximal traces, step, and maximal step traces, and from the corresponding...

  12. 27 CFR 4.37 - Net contents.

    Science.gov (United States)

    2010-04-01

    ... the volume of wine within the container, except that the following tolerances shall be allowed: (1... THE TREASURY LIQUORS LABELING AND ADVERTISING OF WINE Labeling Requirements for Wine § 4.37 Net contents. (a) Statement of net contents. The net contents of wine for which a standard of fill is...

  13. Climatic Forecasting of Net Infiltration at Yucca Montain Using Analogue Meteororological Data

    Energy Technology Data Exchange (ETDEWEB)

    B. Faybishenko

    2006-09-11

    At Yucca Mountain, Nevada, future changes in climatic conditions will most likely alter net infiltration, or the drainage below the bottom of the evapotranspiration zone within the soil profile or flow across the interface between soil and the densely welded part of the Tiva Canyon Tuff. The objectives of this paper are to: (a) develop a semi-empirical model and forecast average net infiltration rates, using the limited meteorological data from analogue meteorological stations, for interglacial (present day), and future monsoon, glacial transition, and glacial climates over the Yucca Mountain region, and (b) corroborate the computed net-infiltration rates by comparing them with the empirically and numerically determined groundwater recharge and percolation rates through the unsaturated zone from published data. In this paper, the author presents an approach for calculations of net infiltration, aridity, and precipitation-effectiveness indices, using a modified Budyko's water-balance model, with reference-surface potential evapotranspiration determined from the radiation-based Penman (1948) formula. Results of calculations show that net infiltration rates are expected to generally increase from the present-day climate to monsoon climate, to glacial transition climate, and then to the glacial climate. The forecasting results indicate the overlap between the ranges of net infiltration for different climates. For example, the mean glacial net-infiltration rate corresponds to the upper-bound glacial transition net infiltration, and the lower-bound glacial net infiltration corresponds to the glacial transition mean net infiltration. Forecasting of net infiltration for different climate states is subject to numerous uncertainties-associated with selecting climate analogue sites, using relatively short analogue meteorological records, neglecting the effects of vegetation and surface runoff and runon on a local scale, as well as possible anthropogenic climate changes.

  14. Editorial Seminar.net Issue 3 Vol. 6

    Directory of Open Access Journals (Sweden)

    Yngve Nordkvelle

    2010-11-01

    Full Text Available Seminar.net reached 100 000 unique visitors in October 2010 after nearly six years on the web. Since its inception, a total number of 64 articles have been published, and the site has been visited 3000 times each month at its most. A journal needs to publish good articles. Judging by the increasing number of readers, the readers seem to find our articles to be relevant, readable and contributing to the global discourse. The e-journal format offers opportunities to employ the media to its full potential. A unique feature of the e-journal is to communicate in other media than textual. Seminar.net has for a long time been alone on the academic marked in the field of presenting an abstract of the paper in video format. The assumption is that a short introduction presented on a video makes the reader more interested and that he/she reads the paper with more enthusiasm. On the other hand, journal readers are conservative, and often fail to appreciate the value of visual communication other than the textual. It will be a challenge to continue to develop the e-journal genre in light of the need to balance reader conservatism with exploring the opportunities offered by multimedia-publishing.The second feature of dealing with an e-journal is to offer an alternative voice. Critique and reappraisal in social science is highly valued and seen as a vital condition for renewal and progress in the academic community. Paper journals are often seen as conservative and in favour of “normal” science in Thomas Kuhn’s terms. The “gatekeepers” are piled up in their editorial boards. E-journals subscribing to an Open Access Policy have a reputation of the opposite. E-journals have made it easier to express critical ideas and represent marginalised viewpoints in main stream science.Seminar.net has readers in 150 countries, from all continents, and with a majority of readers from USA and India, but has also significant number of readers from England, Australia

  15. NET 40 Generics Beginner's Guide

    CERN Document Server

    Mukherjee, Sudipta

    2012-01-01

    This is a concise, practical guide that will help you learn Generics in .NET, with lots of real world and fun-to-build examples and clear explanations. It is packed with screenshots to aid your understanding of the process. This book is aimed at beginners in Generics. It assumes some working knowledge of C# , but it isn't mandatory. The following would get the most use out of the book: Newbie C# developers struggling with Generics. Experienced C++ and Java Programmers who are migrating to C# and looking for an alternative to other generic frameworks like STL and JCF would find this book handy.

  16. The Net Reclassification Index (NRI)

    DEFF Research Database (Denmark)

    Pepe, Margaret S.; Fan, Jing; Feng, Ziding

    2015-01-01

    The Net Reclassification Index (NRI) is a very popular measure for evaluating the improvement in prediction performance gained by adding a marker to a set of baseline predictors. However, the statistical properties of this novel measure have not been explored in depth. We demonstrate the alarming...... marker is proven to erroneously yield a positive NRI. Some insight into this phenomenon is provided. Since large values for the NRI statistic may simply be due to use of poorly fitting risk models, we suggest caution in using the NRI as the basis for marker evaluation. Other measures of prediction...

  17. APROACHING THE ECONOMIC DIMENSION OF SUSTAINABLE DEVELOPMENT FROM A FINANCIAL PERSPECTIVE: A CASE STUDY REGARDING CASH - FLOW ANALYSIS AND THE RELATIONSIPS BETWEEN CASH - FLOW AND NET INCOME

    Directory of Open Access Journals (Sweden)

    Diana Elena Vasiu

    2014-10-01

    Full Text Available Europe 2020, a strategy for smart, sustainable and inclusive growth stresses the necessity of smart, sustainable and inclusive growth. The objectives of a sustainable economic development include sustaining economic growth, maximizing private profits and expanding markets. Considering this, economic development must based on facts, not on papers. Therefore, considering the economic dimension of sustainable development, it is important to establish if Romanian companies listed and traded on Bucharest Stock Exchange are able to obtain profit while cash is withdrawn. Even if reported in the income statement, net profit is not simultaneously charged due to accrual accounting that makes the balance sheet provide a static picture of the financial position, while the cash flow statement provides a dynamic picture of it. Therefore, the financial performance analysis based on classical indicators of performance must be accompanied by the analysis of treasury, namely of the cash flow, which provides a comprehensive assessment possibility of the financial performance, flexibility and adaptability of the economic entity, in the context of a highly competitive and often unstable environment. A positive net flows is a confirmation of the economic success of the company representing the concrete expression of the net profit and other pecuniary accumulations, interpreted as the real self-financing investment capacity, which would lead to the real asset growth and thus to the increase of the owners' wealth.

  18. Windows with an improved energy balance of 30%

    DEFF Research Database (Denmark)

    Schultz, Jørgen Munthe

    carried out in the project. The large glass distance helps to reduce the traditional thermal bridge effect of the spacer and the integrated frame leads to an increase in transmitted solar energy. Furthermore, a controlled air exchange in case of pressure differences between the enclosures in the glazing......The aim of the project has been to investigate and to develop thermally improved windows based on an evaluation of the energy balance of the window, i.e. the total influence of the window on the energy consumption for space heating. The energy balance is the net heat flow per window area which...... been developed, which combines the results from several different building types and building orientations. The energy balance of the reference window has been calculated to -50 kWh/m2 window area, i.e. the refence window accounts for a net energy consumption for space heating of 50 kWh/m2 window area...

  19. Tropical forests are a net carbon source based on aboveground measurements of gain and loss

    Science.gov (United States)

    Baccini, A.; Walker, W.; Carvalho, L.; Farina, M.; Sulla-Menashe, D.; Houghton, R. A.

    2017-10-01

    The carbon balance of tropical ecosystems remains uncertain, with top-down atmospheric studies suggesting an overall sink and bottom-up ecological approaches indicating a modest net source. Here we use 12 years (2003 to 2014) of MODIS pantropical satellite data to quantify net annual changes in the aboveground carbon density of tropical woody live vegetation, providing direct, measurement-based evidence that the world’s tropical forests are a net carbon source of 425.2 ± 92.0 teragrams of carbon per year (Tg C year–1). This net release of carbon consists of losses of 861.7 ± 80.2 Tg C year–1 and gains of 436.5 ± 31.0 Tg C year–1. Gains result from forest growth; losses result from deforestation and from reductions in carbon density within standing forests (degradation or disturbance), with the latter accounting for 68.9% of overall losses.

  20. Maximality-Based Structural Operational Semantics for Petri Nets

    Science.gov (United States)

    Saīdouni, Djamel Eddine; Belala, Nabil; Bouneb, Messaouda

    2009-03-01

    The goal of this work is to exploit an implementable model, namely the maximality-based labeled transition system, which permits to express true-concurrency in a natural way without splitting actions on their start and end events. One can do this by giving a maximality-based structural operational semantics for the model of Place/Transition Petri nets in terms of maximality-based labeled transition systems structures.

  1. Optical neural net for classifying imaging spectrometer data

    Science.gov (United States)

    Barnard, Etienne; Casasent, David P.

    1989-01-01

    The problem of determining the composition of an unknown input mixture from its measured spectrum, given the spectra of a number of elements, is studied. The Hopfield minimization procedure was used to express the determination of the compositions as a problem suitable for solution by neural nets. A mathematical description of the problem was developed and used as a basis for a neural network solution and an optical implementation.

  2. Balance Toward Language Mastery

    National Research Council Canada - National Science Library

    Virginia R Heslinga

    2017-01-01

    .... Augmentative, alternative, interactive, accommodating, and enriching strategies using sign language aid learners in balancing the skills needed to mastery of one language or multiple languages...

  3. Energy Balance Bowen Ratio (EBBR) Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Cook, D. R. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-01-01

    The Energy Balance Bowen Ratio (EBBR) system produces 30-minute estimates of the vertical fluxes of sensible and latent heat at the local surface. Flux estimates are calculated from observations of net radiation, soil surface heat flux, and the vertical gradients of temperature and relative humidity (RH). Meteorological data collected by the EBBR are used to calculate bulk aerodynamic fluxes, which are used in the Bulk Aerodynamic Technique (BA) EBBR value-added product (VAP) to replace sunrise and sunset spikes in the flux data. A unique aspect of the system is the automatic exchange mechanism (AEM), which helps to reduce errors from instrument offset drift.

  4. Energy Balance Bowen Ratio Station (EBBR) Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Cook, DR

    2011-02-23

    The energy balance Bowen ratio (EBBR) system produces 30-minute estimates of the vertical fluxes of sensible and latent heat at the local surface. Flux estimates are calculated from observations of net radiation, soil surface heat flux, and the vertical gradients of temperature and relative humidity (RH). Meteorological data collected by the EBBR are used to calculate bulk aerodynamic fluxes, which are used in the Bulk Aerodynamic Technique (BA) EBBR value-added product (VAP) to replace sunrise and sunset spikes in the flux data. A unique aspect of the system is the automatic exchange mechanism (AEM), which helps to reduce errors from instrument offset drift.

  5. A net clinical benefit analysis of warfarin and aspirin on stroke in patients with atrial fibrillation: a nested case–control study

    Directory of Open Access Journals (Sweden)

    Azoulay Laurent

    2012-06-01

    Full Text Available Abstract Background As the management of patients treated with anticoagulants and antiplatelet drugs entails balancing coagulation levels, we evaluated the net clinical benefit of warfarin and aspirin on stroke in a large cohort of patients with atrial fibrillation (AF. Methods A population-based cohort study of all patients at least 18 years of age with a first-ever diagnosis of chronic AF during the period 1993–2008 was conducted within the United Kingdom General Practice Research Database. A nested case–control analysis was conducted to estimate the risk of ischemic stroke and intracranial hemorrhage associated with the use of warfarin and aspirin. Cases were matched up to 10 controls on age, sex, and date of cohort entry. The adjusted net clinical benefit of warfarin and aspirin (expressed as the number of strokes prevented per 100 persons per year was calculated by subtracting the ischemic stroke rate (prevented by therapy from the intracranial hemorrhage (ICH rate (increased by therapy. Results The cohort included 70,766 patients newly-diagnosed with chronic AF, of whom 5519 experienced an ischemic stroke and 689 an ICH during follow-up. The adjusted net clinical benefit of warfarin was 0.59 (95% CI: 0.45, 0.73. However, the benefit was not seen for patients below (0.08, 95%: -0.38, 0.54 and above (−0.49, 95% CI: -1.13, 0.15 therapeutic range. The net clinical benefit of warfarin, apparent after 3 months of continuous use, increased as a function of CHADS2 score. The net clinical benefit was not significant with aspirin (−0.07, 95% CI: -0.22, 0.08, though it was seen in certain subgroups. Conclusions Warfarin provides a net clinical benefit in patients with atrial fibrillation, which is maintained with longer duration of use, particularly when used within therapeutic range. A similar net effect is not as clear with aspirin.

  6. -Net Approach to Sensor -Coverage

    Directory of Open Access Journals (Sweden)

    Fusco Giordano

    2010-01-01

    Full Text Available Wireless sensors rely on battery power, and in many applications it is difficult or prohibitive to replace them. Hence, in order to prolongate the system's lifetime, some sensors can be kept inactive while others perform all the tasks. In this paper, we study the -coverage problem of activating the minimum number of sensors to ensure that every point in the area is covered by at least sensors. This ensures higher fault tolerance, robustness, and improves many operations, among which position detection and intrusion detection. The -coverage problem is trivially NP-complete, and hence we can only provide approximation algorithms. In this paper, we present an algorithm based on an extension of the classical -net technique. This method gives an -approximation, where is the number of sensors in an optimal solution. We do not make any particular assumption on the shape of the areas covered by each sensor, besides that they must be closed, connected, and without holes.

  7. NETS - Danish participation. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Alsen, S. (Grontmij - Carl Bro, Glostrup (Denmark)); Theel, C. (Baltic Sea Solutions, Holeby (Denmark))

    2008-12-15

    Within the NICe-funded project 'Nordic Environmental Technology Solutions (NETS)' a new type of networking at the Nordic level was organized in order to jointly exploit the rapidly growing market potential in the environmental technology sector. The project aimed at increased and professionalized commercialization of Nordic Cleantech in energy and water business segments through 1) closer cooperation and joint marketing activities, 2) a website, 3) cleantech product information via brochures and publications 4) and participating in relevant trade fairs and other industry events. Facilitating business-to-business activities was another core task for the NETS project partners from Norway, Sweden, Finland and Denmark with the aim to encourage total solutions for combined Cleantech system offers. The project has achieved to establish a Cleantech register of 600 Nordic Cleantech companies, a network of 86 member enterprises, produced several publications and brochures for direct technology promotion and a website for direct access to company profiles and contact data. The project partners have attended 14 relevant international Cleantech trade fairs and conferences and facilitated business-to-business contacts added by capacity building offers through two company workshops. The future challenge for the project partners and Nordic Cleantech will be to coordinate the numerous efforts within the Nordic countries in order to reach concerted action and binding of member companies for reliable services, an improved visibility and knowledge exchange. With Cleantech's growing market influence and public awareness, the need to develop total solutions is increasing likewise. Marketing efforts should be encouraged cross-sectional and cross-border among the various levels of involved actors from both the public and the private sector. (au)

  8. Identifying Balance in a Balanced Scorecard System

    Science.gov (United States)

    Aravamudhan, Suhanya; Kamalanabhan, T. J.

    2007-01-01

    In recent years, strategic management concepts seem to be gaining greater attention from the academicians and the practitioner's alike. Balanced Scorecard (BSC) concept is one such management concepts that has spread in worldwide business and consulting communities. The BSC translates mission and vision statements into a comprehensive set of…

  9. Surface Energy Balance System (SEBS) Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Cook, D. R. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-01-01

    A Surface Energy Balance System (SEBS) has been installed collocated with each deployed Eddy Correlation Flux Measurement System (ECOR) at the Atmospheric Radiation Measurement (ARM) Climate Research Facility’s Southern Great Plains (SGP) site, North Slope of Alaska (NSA) site, first ARM Mobile Facility (AMF1), second ARM Mobile Facility (AMF2), and third ARM Mobile Facility (AMF3) at Oliktok Point (OLI). A SEBS was also deployed with the Tropical Western Pacific (TWP) site, before it was decommissioned. Data from these sites, including the retired TWP, are available in the ARM Data Archive. The SEBS consists of upwelling and downwelling solar and infrared radiometers within one net radiometer, a wetness sensor, and soil measurements. The SEBS measurements allow the comparison of ECOR sensible and latent heat fluxes with the energy balance determined from the SEBS and provide information on wetting of the sensors for data quality purposes.

  10. An analytical method for well-formed workflow/Petri net verification of classical soundness

    Directory of Open Access Journals (Sweden)

    Clempner Julio

    2014-12-01

    Full Text Available In this paper we consider workflow nets as dynamical systems governed by ordinary difference equations described by a particular class of Petri nets. Workflow nets are a formal model of business processes. Well-formed business processes correspond to sound workflow nets. Even if it seems necessary to require the soundness of workflow nets, there exist business processes with conditional behavior that will not necessarily satisfy the soundness property. In this sense, we propose an analytical method for showing that a workflow net satisfies the classical soundness property using a Petri net. To present our statement, we use Lyapunov stability theory to tackle the classical soundness verification problem for a class of dynamical systems described by Petri nets. This class of Petri nets allows a dynamical model representation that can be expressed in terms of difference equations. As a result, by applying Lyapunov theory, the classical soundness property for workflow nets is solved proving that the Petri net representation is stable. We show that a finite and non-blocking workflow net satisfies the sound property if and only if its corresponding PN is stable, i.e., given the incidence matrix A of the corresponding PN, there exists a Փ strictly positive m vector such that AՓ≤ 0. The key contribution of the paper is the analytical method itself that satisfies part of the definition of the classical soundness requirements. The method is designed for practical applications, guarantees that anomalies can be detected without domain knowledge, and can be easily implemented into existing commercial systems that do not support the verification of workflows. The validity of the proposed method is successfully demonstrated by application examples.

  11. Balancing energy flexibilities through aggregation

    DEFF Research Database (Denmark)

    Valsomatzis, Emmanouil; Hose, Katja; Pedersen, Torben Bach

    2014-01-01

    in both energy production and consumption, is the key to solving these problems. Flexibilities can be expressed as flex-offers, which due to their high number need to be aggregated to reduce the complexity of energy scheduling. In this paper, we discuss balance aggregation techniques that already during......One of the main goals of recent developments in the Smart Grid area is to increase the use of renewable energy sources. These sources are characterized by energy fluctuations that might lead to energy imbalances and congestions in the electricity grid. Exploiting inherent flexibilities, which exist...

  12. Leadership: A Balancing Act

    Science.gov (United States)

    Hines, Thomas E.

    2011-01-01

    Maintaining balance in leadership can be difficult because balance is affected by the personality, strengths, and attitudes of the leader as well as the complicated environment within and outside the community college itself. This article explores what being a leader at the community college means, what the threats are to effective leadership, and…

  13. Conclusion: The balanced company

    DEFF Research Database (Denmark)

    Scheuer, John Damm; Jensen, Inger

    2013-01-01

    This concluding chapter brings together the various research findings of the book "The balanced company - organizing for the 21st Century" and develops a general overview of their implications for our understanding of the balancing processes unfolding in companies and organizations....

  14. Application and Theory of Petri Nets

    DEFF Research Database (Denmark)

    This volume contains the proceedings of the 13th International Conference onApplication and Theory of Petri Nets, held in Sheffield, England, in June 1992. The aim of the Petri net conferences is to create a forum for discussing progress in the application and theory of Petri nets. Typically....... Balbo and W. Reisig, 18 submitted papers, and seven project papers. The submitted papers and project presentations were selectedby the programme committee and a panel of referees from a large number of submissions....

  15. Are You Neutral About Net Neutrality

    Science.gov (United States)

    2007-06-20

    Information Resources Management College National Defense University Are You Neutral About Net Neutrality ? A presentation for Systems & Software...author uses Verizon FiOS for phone, TV, and internet service 3 Agenda Net Neutrality —Through 2 Lenses Who Are the Players & What Are They Saying...Medical Treatment Mini-Case Studies Updates Closing Thoughts 4 Working Definitions of Net Neutrality "Network Neutrality" is the concept that

  16. Texture Based Image Analysis With Neural Nets

    Science.gov (United States)

    Ilovici, Irina S.; Ong, Hoo-Tee; Ostrander, Kim E.

    1990-03-01

    In this paper, we combine direct image statistics and spatial frequency domain techniques with a neural net model to analyze texture based images. The resultant optimal texture features obtained from the direct and transformed image form the exemplar pattern of the neural net. The proposed approach introduces an automated texture analysis applied to metallography for determining the cooling rate and mechanical working of the materials. The results suggest that the proposed method enhances the practical applications of neural nets and texture extraction features.

  17. Factors associated with mosquito net use by individuals in households owning nets in Ethiopia

    Directory of Open Access Journals (Sweden)

    Graves Patricia M

    2011-12-01

    Full Text Available Abstract Background Ownership of insecticidal mosquito nets has dramatically increased in Ethiopia since 2006, but the proportion of persons with access to such nets who use them has declined. It is important to understand individual level net use factors in the context of the home to modify programmes so as to maximize net use. Methods Generalized linear latent and mixed models (GLLAMM were used to investigate net use using individual level data from people living in net-owning households from two surveys in Ethiopia: baseline 2006 included 12,678 individuals from 2,468 households and a sub-sample of the Malaria Indicator Survey (MIS in 2007 included 14,663 individuals from 3,353 households. Individual factors (age, sex, pregnancy; net factors (condition, age, net density; household factors (number of rooms [2006] or sleeping spaces [2007], IRS, women's knowledge and school attendance [2007 only], wealth, altitude; and cluster level factors (rural or urban were investigated in univariate and multi-variable models for each survey. Results In 2006, increased net use was associated with: age 25-49 years (adjusted (a OR = 1.4, 95% confidence interval (CI 1.2-1.7 compared to children U5; female gender (aOR = 1.4; 95% CI 1.2-1.5; fewer nets with holes (Ptrend = 0.002; and increasing net density (Ptrend [all nets in HH good] = 1.6; 95% CI 1.2-2.1; increasing net density (Ptrend [per additional space] = 0.6, 95% CI 0.5-0.7; more old nets (aOR [all nets in HH older than 12 months] = 0.5; 95% CI 0.3-0.7; and increasing household altitude (Ptrend Conclusion In both surveys, net use was more likely by women, if nets had fewer holes and were at higher net per person density within households. School-age children and young adults were much less likely to use a net. Increasing availability of nets within households (i.e. increasing net density, and improving net condition while focusing on education and promotion of net use, especially in school-age children

  18. Pro Agile NET Development with Scrum

    CERN Document Server

    Blankenship, Jerrel; Millett, Scott

    2011-01-01

    Pro Agile .NET Development with SCRUM guides you through a real-world ASP.NET project and shows how agile methodology is put into practice. There is plenty of literature on the theory behind agile methodologies, but no book on the market takes the concepts of agile practices and applies these in a practical manner to an end-to-end ASP.NET project, especially the estimating, requirements and management aspects of a project. Pro Agile .NET Development with SCRUM takes you through the initial stages of a project - gathering requirements and setting up an environment - through to the development a

  19. Pro ASP.NET MVC 4

    CERN Document Server

    Freeman, Adam

    2012-01-01

    The ASP.NET MVC 4 Framework is the latest evolution of Microsoft's ASP.NET web platform. It provides a high-productivity programming model that promotes cleaner code architecture, test-driven development, and powerful extensibility, combined with all the benefits of ASP.NET. ASP.NET MVC 4 contains a number of significant advances over previous versions. New mobile and desktop templates (employing adaptive rendering) are included together with support for jQuery Mobile for the first time. New display modes allow your application to select views based on the browser that's making the request whi

  20. Professional Visual Basic 2010 and .NET 4

    CERN Document Server

    Sheldon, Bill; Sharkey, Kent

    2010-01-01

    Intermediate and advanced coverage of Visual Basic 2010 and .NET 4 for professional developers. If you've already covered the basics and want to dive deep into VB and .NET topics that professional programmers use most, this is your book. You'll find a quick review of introductory topics-always helpful-before the author team of experts moves you quickly into such topics as data access with ADO.NET, Language Integrated Query (LINQ), security, ASP.NET web programming with Visual Basic, Windows workflow, threading, and more. You'll explore all the new features of Visual Basic 2010 as well as all t

  1. Towards a Standard for Modular Petri Nets

    DEFF Research Database (Denmark)

    Kindler, Ekkart; Petrucci, Laure

    2009-01-01

    When designing complex systems, mechanisms for structuring, composing, and reusing system components are crucial. Today, there are many approaches for equipping Petri nets with such mechanisms. In the context of defining a standard interchange format for Petri nets, modular PNML was defined....... Moreover, we present and discuss some more advanced features of modular Petri nets that could be included in the standard. This way, we provide a formal foundation and a basis for a discussion of features to be included in the upcoming standard of a module concept for Petri nets in general and for high...

  2. Net carbon exchange across the Arctic tundra-boreal forest transition in Alaska 1981-2000

    Science.gov (United States)

    Thompson, Catharine Copass; McGuire, A.D.; Clein, Joy S.; Chapin, F. S.; Beringer, J.

    2006-01-01

    Shifts in the carbon balance of high-latitude ecosystems could result from differential responses of vegetation and soil processes to changing moisture and temperature regimes and to a lengthening of the growing season. Although shrub expansion and northward movement of treeline should increase carbon inputs, the effects of these vegetation changes on net carbon exchange have not been evaluated. We selected low shrub, tall shrub, and forest tundra sites near treeline in northwestern Alaska, representing the major structural transitions expected in response to warming. In these sites, we measured aboveground net primary production (ANPP) and vegetation and soil carbon and nitrogen pools, and used these data to parameterize the Terrestrial Ecosystem Model. We simulated the response of carbon balance components to air temperature and precipitation trends during 1981-2000. In areas experiencing warmer and dryer conditions, Net Primary Production (NPP) decreased and heterotrophic respiration (R H ) increased, leading to a decrease in Net Ecosystem Production (NEP). In warmer and wetter conditions NPP increased, but the response was exceeded by an increase in R H ; therefore, NEP also decreased. Lastly, in colder and wetter regions, the increase in NPP exceeded a small decline in R H , leading to an increase in NEP. The net effect for the region was a slight gain in ecosystem carbon storage over the 20 year period. This research highlights the potential importance of spatial variability in ecosystem responses to climate change in assessing the response of carbon storage in northern Alaska over the last two decades. ?? Springer 2005.

  3. Experiments and simulation of a net closing mechanism for tether-net capture of space debris

    Science.gov (United States)

    Sharf, Inna; Thomsen, Benjamin; Botta, Eleonora M.; Misra, Arun K.

    2017-10-01

    This research addresses the design and testing of a debris containment system for use in a tether-net approach to space debris removal. The tether-net active debris removal involves the ejection of a net from a spacecraft by applying impulses to masses on the net, subsequent expansion of the net, the envelopment and capture of the debris target, and the de-orbiting of the debris via a tether to the chaser spacecraft. To ensure a debris removal mission's success, it is important that the debris be successfully captured and then, secured within the net. To this end, we present a concept for a net closing mechanism, which we believe will permit consistently successful debris capture via a simple and unobtrusive design. This net closing system functions by extending the main tether connecting the chaser spacecraft and the net vertex to the perimeter and around the perimeter of the net, allowing the tether to actuate closure of the net in a manner similar to a cinch cord. A particular embodiment of the design in a laboratory test-bed is described: the test-bed itself is comprised of a scaled-down tether-net, a supporting frame and a mock-up debris. Experiments conducted with the facility demonstrate the practicality of the net closing system. A model of the net closure concept has been integrated into the previously developed dynamics simulator of the chaser/tether-net/debris system. Simulations under tether tensioning conditions demonstrate the effectiveness of the closure concept for debris containment, in the gravity-free environment of space, for a realistic debris target. The on-ground experimental test-bed is also used to showcase its utility for validating the dynamics simulation of the net deployment, and a full-scale automated setup would make possible a range of validation studies of other aspects of a tether-net debris capture mission.

  4. Daily variation in net primary production and net calcification in coral reef communities exposed to elevated pCO2

    Science.gov (United States)

    Comeau, Steeve; Edmunds, Peter J.; Lantz, Coulson A.; Carpenter, Robert C.

    2017-07-01

    The threat represented by ocean acidification (OA) for coral reefs has received considerable attention because of the sensitivity of calcifiers to changing seawater carbonate chemistry. However, most studies have focused on the organismic response of calcification to OA, and only a few have addressed community-level effects, or investigated parameters other than calcification, such as photosynthesis. Light (photosynthetically active radiation, PAR) is a driver of biological processes on coral reefs, and the possibility that these processes might be perturbed by OA has important implications for community function. Here we investigate how CO2 enrichment affects the relationships between PAR and community net O2 production (Pnet), and between PAR and community net calcification (Gnet), using experiments on three coral communities constructed to match (i) the back reef of Mo'orea, French Polynesia, (ii) the fore reef of Mo'orea, and (iii) the back reef of O'ahu, Hawaii. The results were used to test the hypothesis that OA affects the relationship between Pnet and Gnet. For the three communities tested, pCO2 did not affect the Pnet-PAR relationship, but it affected the intercept of the hyperbolic tangent curve fitting the Gnet-PAR relationship for both reef communities in Mo'orea (but not in O'ahu). For the three communities, the slopes of the linear relationships between Pnet and Gnet were not affected by OA, although the intercepts were depressed by the inhibitory effect of high pCO2 on Gnet. Our result indicates that OA can modify the balance between net calcification and net photosynthesis of reef communities by depressing community calcification, but without affecting community photosynthesis.

  5. Daily variation in net primary production and net calcification in coral reef communities exposed to elevated pCO2

    Directory of Open Access Journals (Sweden)

    S. Comeau

    2017-07-01

    Full Text Available The threat represented by ocean acidification (OA for coral reefs has received considerable attention because of the sensitivity of calcifiers to changing seawater carbonate chemistry. However, most studies have focused on the organismic response of calcification to OA, and only a few have addressed community-level effects, or investigated parameters other than calcification, such as photosynthesis. Light (photosynthetically active radiation, PAR is a driver of biological processes on coral reefs, and the possibility that these processes might be perturbed by OA has important implications for community function. Here we investigate how CO2 enrichment affects the relationships between PAR and community net O2 production (Pnet, and between PAR and community net calcification (Gnet, using experiments on three coral communities constructed to match (i the back reef of Mo'orea, French Polynesia, (ii the fore reef of Mo'orea, and (iii the back reef of O'ahu, Hawaii. The results were used to test the hypothesis that OA affects the relationship between Pnet and Gnet. For the three communities tested, pCO2 did not affect the Pnet–PAR relationship, but it affected the intercept of the hyperbolic tangent curve fitting the Gnet–PAR relationship for both reef communities in Mo'orea (but not in O'ahu. For the three communities, the slopes of the linear relationships between Pnet and Gnet were not affected by OA, although the intercepts were depressed by the inhibitory effect of high pCO2 on Gnet. Our result indicates that OA can modify the balance between net calcification and net photosynthesis of reef communities by depressing community calcification, but without affecting community photosynthesis.

  6. Interactions with insulin and dexamethasone in net synthesis of albumin and acute-phase proteins

    Energy Technology Data Exchange (ETDEWEB)

    Miller, L.L.

    1976-01-01

    The isolated rat liver perfused for 12 hours at pH 7.10 with a suspension of bovine erythrocytes in Krebs--Ringer bicarbonate buffer containing 3% bovine serum albumin has been used as a test system to study effects of glucagon and of dexamethasone in the presence and absence of insulin on net biosynthesis of rat serum albumin, fibrinogen, ..cap alpha../sub 1/-acid glycoprotein, ..cap alpha../sub 2/-(acute phase) globulin, and haptoglobin. Quantitative measurement of perfusate glucose, amino acid nitrogen, and urea affords a basis for determining net glucose and nitrogen balance in the perfusion system. Although the dose of dexamethasone (total 1.0 ..mu..g) used was insufficient to induce synthesis of ..cap alpha../sub 2/-acute phase globulin, net syntheses of albumin, fibrinogen, ..cap alpha../sub 1/-acid glycoprotein, and haptoglobin were increased. Glucagon given with dexamethasone depressed albumin and haptoglobin synthesis markedly, but not that of fibrinogen and ..cap alpha../sub 1/-acid glycoprotein. Glucagon with dexamethasone markedly enhanced ureogenesis and glycogenolysis and elicited an exaggerated negative nitrogen balance. The unfavorable effects of glucagon on albumin and haptoglobin synthesis and on nitrogen balance were reversed by giving insulin simultaneously. It is emphasized that insulin is essential for positive nitrogen balance.

  7. Load Balancing Scientific Applications

    Energy Technology Data Exchange (ETDEWEB)

    Pearce, Olga Tkachyshyn [Texas A & M Univ., College Station, TX (United States)

    2014-12-01

    The largest supercomputers have millions of independent processors, and concurrency levels are rapidly increasing. For ideal efficiency, developers of the simulations that run on these machines must ensure that computational work is evenly balanced among processors. Assigning work evenly is challenging because many large modern parallel codes simulate behavior of physical systems that evolve over time, and their workloads change over time. Furthermore, the cost of imbalanced load increases with scale because most large-scale scientific simulations today use a Single Program Multiple Data (SPMD) parallel programming model, and an increasing number of processors will wait for the slowest one at the synchronization points. To address load imbalance, many large-scale parallel applications use dynamic load balance algorithms to redistribute work evenly. The research objective of this dissertation is to develop methods to decide when and how to load balance the application, and to balance it effectively and affordably. We measure and evaluate the computational load of the application, and develop strategies to decide when and how to correct the imbalance. Depending on the simulation, a fast, local load balance algorithm may be suitable, or a more sophisticated and expensive algorithm may be required. We developed a model for comparison of load balance algorithms for a specific state of the simulation that enables the selection of a balancing algorithm that will minimize overall runtime.

  8. Net-Zero Energy Buildings: A Classification System Based on Renewable Energy Supply Options

    Energy Technology Data Exchange (ETDEWEB)

    Pless, S.; Torcellini, P.

    2010-06-01

    A net-zero energy building (NZEB) is a residential or commercial building with greatly reduced energy needs. In such a building, efficiency gains have been made such that the balance of energy needs can be supplied with renewable energy technologies. Past work has developed a common NZEB definition system, consisting of four well-documented definitions, to improve the understanding of what net-zero energy means. For this paper, we created a classification system for NZEBs based on the renewable sources a building uses.

  9. HANPP Collection: Human Appropriation of Net Primary Productivity as a Percentage of Net Primary Productivity

    Data.gov (United States)

    National Aeronautics and Space Administration — The Human Appropriation of Net Primary Productivity (HANPP) as a Percentage of Net Primary Product (NPP) portion of the HANPP Collection represents a map identifying...

  10. Price smarter on the Net.

    Science.gov (United States)

    Baker, W; Marn, M; Zawada, C

    2001-02-01

    Companies generally have set prices on the Internet in two ways. Many start-ups have offered untenably low prices in a rush to capture first-mover advantage. Many incumbents have simply charged the same prices on-line as they do off-line. Either way, companies are missing a big opportunity. The fundamental value of the Internet lies not in lowering prices or making them consistent but in optimizing them. After all, if it's easy for customers to compare prices on the Internet, it's also easy for companies to track customers' behavior and adjust prices accordingly. The Net lets companies optimize prices in three ways. First, it lets them set and announce prices with greater precision. Different prices can be tested easily, and customers' responses can be collected instantly. Companies can set the most profitable prices, and they can tap into previously hidden customer demand. Second, because it's so easy to change prices on the Internet, companies can adjust prices in response to even small fluctuations in market conditions, customer demand, or competitors' behavior. Third, companies can use the clickstream data and purchase histories that it collects through the Internet to segment customers quickly. Then it can offer segment-specific prices or promotions immediately. By taking full advantage of the unique possibilities afforded by the Internet to set prices with precision, adapt to changing circumstances quickly, and segment customers accurately, companies can get their pricing right. It's one of the ultimate drivers of e-business success.

  11. Energy balance measurement

    DEFF Research Database (Denmark)

    Dhurandhar, N V; Schoeller, D; Brown, A W

    2015-01-01

    -reports of EI and PAEE are imperfect, but nevertheless deserving of use, to a view commensurate with the evidence that self-reports of EI and PAEE are so poor that they are wholly unacceptable for scientific research on EI and PAEE. While new strategies for objectively determining energy balance......Energy intake (EI) and physical activity energy expenditure (PAEE) are key modifiable determinants of energy balance, traditionally assessed by self-report despite its repeated demonstration of considerable inaccuracies. We argue here that it is time to move from the common view that self...... of energy balance....

  12. Ankylosing Spondylitis and Balance.

    Science.gov (United States)

    Uckun, Alper; Sezer, Ilhan

    2017-10-01

    Ankylosing spondylitis is a chronic inflammatory disease that mainly affects axial joints and the changes in the vertebrae cause typical kyphotic posture. In patients with ankylosing spondylitis, the postural changes, including cervical flexion, decreased lumbar lordosis, posterior rotation of pelvis, hip extension, knee flexion, and plantar flexion of ankle along with kyphosis, may occur in the upcoming terms of the disease and may negatively affect balance. Joint and eye involvements; muscular, vestibular and proprioceptional changes can also affect balance. This review evaluates the ankylosing spondylitis-equilibrium relationship together with posture and other parameters of balance.

  13. Impact of bioenergy on regionalized nitrogen balances

    Science.gov (United States)

    Häußermann, Uwe; Klement, Laura; Bach, Martin

    2017-04-01

    Results of regionalized and overall net-N-balances are used to fulfil different reporting obligations, as well as input data for nitrate leaching modelling (Bach et al. 2014). For Germany, these regionalized net-N-balances are calculated for 402 administrative units on the NUTS-III-level (Landkreise and kreisfreie Städte in Germany), 16 administrative units on the NUTS-I-level (Bundesländer in Germany) and the whole country for every year from 1995 to 2015. The so far existing net-N-balancing method includes nitrogen inputs and outputs of crop production and animal husbandry, however, not the utilization of crops and farmyard manure for energy production (Bach et al. 2014). Due to the introduction of guaranteed feed in tariffs for electricity production from biomass by the German renewable energy law in 2000 and the introduction of more favourable conditions for electricity production from biogas in 2004 (EEG 2000, EEG 2004) in the frame of the German policy of energy transition towards renewable energies („Energiewende"), the electric capacity of biogas plants had a steep increase in the years afterwards, the installed electric capacity increased from 149 MW in 2004 to 5080 MW in 2015 (BMWi and AGEE Stat 2016). The cropping area for the production of energy cops for biogas production increased as well from 0.4 Mio ha in 2007 to 1.393 Mio ha in 2015 (Statista 2017). We introduced a method to calculate the nitrogen input via energy crops, farmyard manure and organic waste, output via biogas digestates and gaseous nitrogen losses via NH3, N2O, NOx and N2 during the anaerobic digestion, digestate storage and spreading on the field, the emission factors for these nitrogen species are obtained from the report on methods and data for the agricultural part of the German national greenhouse gas inventory and informative inventory report (Haenel et al. 2016). To obtain highly resolved information on the distribution and capacity of biogas plants on NUTS-III-level, we

  14. 78 FR 72393 - Net Investment Income Tax

    Science.gov (United States)

    2013-12-02

    ... Investment Income Tax; Final and Proposed Rules #0;#0;Federal Register / Vol. 78, No. 231 / Monday, December... Parts 1 and 602 RIN 1545-BK44 Net Investment Income Tax AGENCY: Internal Revenue Service (IRS), Treasury... Investment Income Tax and the computation of Net Investment Income. The regulations affect individuals...

  15. 77 FR 72611 - Net Investment Income Tax

    Science.gov (United States)

    2012-12-05

    ... December 5, 2012 Part V Department of the Treasury Internal Revenue Service 26 CFR Part 1 Net Investment... Investment Income Tax AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice of proposed rulemaking...) the individual's net investment income for such taxable year, or (B) the excess (if any) of (i) the...

  16. Net analyte signal based statistical quality control

    NARCIS (Netherlands)

    Skibsted, E.T.S.; Boelens, H.F.M.; Westerhuis, J.A.; Smilde, A.K.; Broad, N.W.; Rees, D.R.; Witte, D.T.

    2005-01-01

    Net analyte signal statistical quality control (NAS-SQC) is a new methodology to perform multivariate product quality monitoring based on the net analyte signal approach. The main advantage of NAS-SQC is that the systematic variation in the product due to the analyte (or property) of interest is

  17. Asynchronous stream processing with S-Net

    NARCIS (Netherlands)

    Grelck, C.; Scholz, S.-B.; Shafarenko, A.

    2010-01-01

    We present the rationale and design of S-Net, a coordination language for asynchronous stream processing. The language achieves a near-complete separation between the application code, written in any conventional programming language, and the coordination/communication code written in S-Net. Our

  18. Using the MVC architecture on . NET platform

    OpenAIRE

    Ježek, David

    2011-01-01

    This thesis deals with usage of MVC (Model View Controller) technology in web development on ASP.NET platform from Microsoft. Mainly it deals with latest version of framework ASP.NET MVC 3. First part describes MVC architecture and the second describes usage of MVC in certain parts of web application an comparing with PHP.

  19. Analysis of Petri Nets and Transition Systems

    Directory of Open Access Journals (Sweden)

    Eike Best

    2015-08-01

    Full Text Available This paper describes a stand-alone, no-frills tool supporting the analysis of (labelled place/transition Petri nets and the synthesis of labelled transition systems into Petri nets. It is implemented as a collection of independent, dedicated algorithms which have been designed to operate modularly, portably, extensibly, and efficiently.

  20. 27 CFR 7.27 - Net contents.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Net contents. 7.27 Section 7.27 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF... the net contents are displayed by having the same blown, branded, or burned in the container in...

  1. Petri nets and other models of concurrency

    DEFF Research Database (Denmark)

    Nielsen, Mogens; Sassone, Vladimiro

    1998-01-01

    This paper retraces, collects, and summarises contributions of the authors - in collaboration with others - on the theme of Petri nets and their categorical relationships to other models of concurrency.......This paper retraces, collects, and summarises contributions of the authors - in collaboration with others - on the theme of Petri nets and their categorical relationships to other models of concurrency....

  2. Delta Semantics Defined By Petri Nets

    DEFF Research Database (Denmark)

    Jensen, Kurt; Kyng, Morten; Madsen, Ole Lehrmann

    This report is identical to an earlier version of May 1978 except that Chapter 5 has been revised. A new paper: "A Petri Net Definition of a System Description Language", DAIMI, April 1979, 20 pages, extends the Petri net model to include a data state representing the program variables. Delta...

  3. Net neutrality and inflation of traffic

    NARCIS (Netherlands)

    Peitz, M.; Schütt, Florian

    Under strict net neutrality Internet service providers (ISPs) are required to carry data without any differentiation and at no cost to the content provider. We provide a simple framework with a monopoly ISP to evaluate the short-run effects of different net neutrality rules. Content differs in its

  4. Net Neutrality and Inflation of Traffic

    NARCIS (Netherlands)

    Peitz, M.; Schütt, F.

    2015-01-01

    Under strict net neutrality Internet service providers (ISPs) are required to carry data without any differentiation and at no cost to the content provider. We provide a simple framework with a monopoly ISP to evaluate different net neutrality rules. Content differs in its sensitivity to delay.

  5. The Net Neutrality Debate: The Basics

    Science.gov (United States)

    Greenfield, Rich

    2006-01-01

    Rich Greenfield examines the basics of today's net neutrality debate that is likely to be an ongoing issue for society. Greenfield states the problems inherent in the definition of "net neutrality" used by Common Cause: "Network neutrality is the principle that Internet users should be able to access any web content they choose and…

  6. Dynamic response of the thermometric net radiometer

    Science.gov (United States)

    J. D. Wilson; W. J. Massman; G. E. Swaters

    2009-01-01

    We computed the dynamic response of an idealized thermometric net radiometer, when driven by an oscillating net longwave radiation intended roughly to simulate rapid fluctuations of the radiative environment such as might be expected during field use of such devices. The study was motivated by curiosity as to whether non-linearity of the surface boundary conditions...

  7. Teaching and Learning with the Net Generation

    Science.gov (United States)

    Barnes, Kassandra; Marateo, Raymond C.; Ferris, S. Pixy

    2007-01-01

    As the Net Generation places increasingly greater demands on educators, students and teachers must jointly consider innovative ways of teaching and learning. In this, educators are supported by the fact that the Net Generation wants to learn. However, these same educators should not fail to realize that this generation learns differently from…

  8. Verification of Timed-Arc Petri Nets

    DEFF Research Database (Denmark)

    Jacobsen, Lasse; Jacobsen, Morten; Møller, Mikael Harkjær

    2011-01-01

    Timed-Arc Petri Nets (TAPN) are an extension of the classical P/T nets with continuous time. Tokens in TAPN carry an age and arcs between places and transitions are labelled with time intervals restricting the age of tokens available for transition firing. The TAPN model posses a number...

  9. A Brief Introduction to Coloured Petri Nets

    DEFF Research Database (Denmark)

    Jensen, Kurt

    1997-01-01

    Coloured Petri Nets (CP-nets or CPN) is a graphical oriented language for design, specification, simulation and verification of systems. It is in particular well- suited for systems in which communication, synchronisation and resource sharing are important. Typical examples of application areas a...

  10. NetB, a Pore-Forming Toxin from Necrotic Enteritis Strains of Clostridium perfringens

    Directory of Open Access Journals (Sweden)

    Anthony L. Keyburn

    2010-07-01

    Full Text Available The Clostridium perfringens necrotic enteritis B-like toxin (NetB is a recently discovered member of the β-barrel pore-forming toxin family and is produced by a subset of avian C. perfringens type A strains. NetB is cytotoxic for avian cells and is associated with avian necrotic enteritis. This review examines the current state of knowledge of NetB: its role in pathogenesis, its distribution and expression in C. perfringens and its vaccine potential.

  11. Gill net and trammel net selectivity in the northern Aegean Sea, Turkey

    Directory of Open Access Journals (Sweden)

    F. Saadet Karakulak

    2008-09-01

    Full Text Available Fishing trials were carried out with gill nets and trammel nets in the northern Aegean Sea from March 2004 to February 2005. Four different mesh sizes for the gill nets and the inner panel of trammel nets (16, 18, 20 and 22 mm bar length were used. Selectivity parameters for the five most economically important species, bogue (Boops boops, annular sea bream (Diplodus annularis, striped red mullet (Mullus surmuletus, axillary sea bream (Pagellus acarne and blotched picarel (Spicara maena, caught by the two gears were estimated. The SELECT method was used to estimate the selectivity parameters of a variety of models. Catch composition and catch proportion of several species were different in gill and trammel nets. The length frequency distributions of the species caught by the two gears were significantly different. The bi-modal model selectivity curve gave the best fit for gill net and trammel net data, and there was little difference between the modal lengths of these nets. However, a clear difference was found in catching efficiency. The highest catch rates were obtained with the trammel net. Given that many discard species and small fish are caught by gill nets and trammel nets with a mesh size of 16 mm, it is clear that these nets are not appropriate for fisheries. Consequently, the best mesh size for multispecies fisheries is 18 mm. This mesh size will considerably reduce the numbers of small sized individuals and discard species in the catch.

  12. Objective Caml on .NET: The OCamIL Compiler and Toplevel

    OpenAIRE

    Montelatici, Raphaël; Chailloux, Emmanuel; Pagano, Bruno

    2005-01-01

    International audience; We present the OCamIL compiler for Objective Caml that targets .NET. Our experiment consists in adding a new back-end to the INRIA Objective Caml compiler, that generates MSIL bytecode. Among all the advantages of code reuse, ensuring compatibility while keeping all the expressiveness of the original language is particularly interesting. This allowed us to bootstrap the OCamIL compiler as a .NET component and build an interactive loop (toplevel) which may be embedded w...

  13. Discrete, continuous, and hybrid petri nets

    CERN Document Server

    David, René

    2004-01-01

    Petri nets do not designate a single modeling formalism. In fact, newcomers to the field confess sometimes to be a little puzzled by the diversity of formalisms that are recognized under this "umbrella". Disregarding some extensions to the theoretical modeling capabilities, and looking at the level of abstraction of the formalisms, Condition/Event, Elementary, Place/Transition, Predicate/Transition, Colored, Object Oriented... net systems are frequently encountered in the literature. On the other side, provided with appropriate interpretative extensions, Controled Net Systems, Marking Diagrams (the Petri net generalization of State Diagrams), or the many-many variants in which time can be explicitly incorporated -Time(d), Deterministic, (Generalized) Stochastic, Fuzzy...- are defined. This represents another way to define practical formalisms that can be obtained by the "cro- product" of the two mentioned dimensions. Thus Petri nets constitute a modeling paradigm, understandable in a broad sense as "the total...

  14. In Balance With

    Directory of Open Access Journals (Sweden)

    Courtney Kessel

    2013-01-01

    Full Text Available 'In Balance With' (2012 is a live performance with Courtney Kessel and her daughter, Chloé, sitting at opposite ends of a seesaw. During the 30-minute performance, Kessel adds items representative of their lives to Chloé's side of the seesaw. After each group of items is added, she returns to her side to check the balance. Toys, violin, research books, food, pots, tools, and laundry are strapped on to the seesaw. The audience witnesses the struggle to create a balance between work, home, research, and play as a single mother and artist. As equilibrium is achieved, Kessel stills labors to maintain the balance until Chloé is ready to get down, thus signaling that her work can only happen when her daughter is cared for and occupied.

  15. The Balancing Act

    Energy Technology Data Exchange (ETDEWEB)

    Fowler, Kimberly M.

    2008-05-01

    This essay is being proposed as part of a book titled: "Motherhood: The Elephant in the Laboratory." It offers professional and personal advice on how to balance working in the research field with a family life.

  16. Ames Balance Calibration Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — Operations at the lab include calibrating balances for the Ames Wind Tunnels as well as for approved outside projects. Ames has a large inventory of TASK multi-piece...

  17. Balance Disorders (For Parents)

    Science.gov (United States)

    ... implant (a surgically implanted device that helps overcome problems in the inner ear, or cochlea) listening therapy with an audiologist (which uses music and sounds to help kids adapt their hearing and balance) When to See a Doctor It's ...

  18. GEP-NETS update: a review on surgery of gastro-entero-pancreatic neuroendocrine tumors.

    Science.gov (United States)

    Partelli, Stefano; Maurizi, Angela; Tamburrino, Domenico; Baldoni, Andrea; Polenta, Vanessa; Crippa, Stefano; Falconi, Massimo

    2014-10-01

    The incidence of neuroendocrine tumors (NETs) has increased in the last decades. Surgical treatment encompasses a panel of approaches ranging from conservative procedures to extended surgical resection. Tumor size and localization usually represent the main drivers in the choice of the most appropriate surgical resection. In the presence of small (<2 cm) and asymptomatic nonfunctioning NETs, a conservative treatment is usually recommended. For localized NETs measuring above 2 cm, surgical resection represents the cornerstone in the management of these tumors. As they are relatively biologically indolent, an extended resection is often justified also in the presence of advanced NETs. Surgical options for NET liver metastases range from limited resection up to liver transplantation. Surgical choices for metastatic NETs need to consider the extent of disease, the grade of tumor, and the presence of extra-abdominal disease. Any surgical procedures should always be balanced with the benefit of survival or relieving symptoms and patients' comorbidities. © 2014 European Society of Endocrinology.

  19. An Improved Approach for Estimating Daily Net Radiation over the Heihe River Basin

    Directory of Open Access Journals (Sweden)

    Bingfang Wu

    2017-01-01

    Full Text Available Net radiation plays an essential role in determining the thermal conditions of the Earth’s surface and is an important parameter for the study of land-surface processes and global climate change. In this paper, an improved satellite-based approach to estimate the daily net radiation is presented, in which sunshine duration were derived from the geostationary meteorological satellite (FY-2D cloud classification product, the monthly empirical as and bs Angstrom coefficients for net shortwave radiation were calibrated by spatial fitting of the ground data from 1997 to 2006, and the daily net longwave radiation was calibrated with ground data from 2007 to 2010 over the Heihe River Basin in China. The estimated daily net radiation values were validated against ground data for 12 months in 2008 at four stations with different underlying surface types. The average coefficient of determination (R2 was 0.8489, and the averaged Nash-Sutcliffe equation (NSE was 0.8356. The close agreement between the estimated daily net radiation and observations indicates that the proposed method is promising, especially given the comparison between the spatial distribution and the interpolation of sunshine duration. Potential applications include climate research, energy balance studies and the estimation of global evapotranspiration.

  20. Energy Balance and Obesity

    Science.gov (United States)

    Hill, James O.; Wyatt, Holly R.; Peters, John C.

    2012-01-01

    This paper describes the interplay among energy intake, energy expenditure and body energy stores and illustrates how an understanding of energy balance can help develop strategies to reduce obesity. First, reducing obesity will require modifying both energy intake and energy expenditure and not simply focusing on either alone. Food restriction alone will not be effective in reducing obesity if human physiology is biased toward achieving energy balance at a high energy flux (i.e. at a high level of energy intake and expenditure). In previous environments a high energy flux was achieved with a high level of physical activity but in today's sedentary environment it is increasingly achieved through weight gain. Matching energy intake to a high level of energy expenditure will likely be more a more feasible strategy for most people to maintain a healthy weight than restricting food intake to meet a low level of energy expenditure. Second, from an energy balance point of view we are likely to be more successful in preventing excessive weight gain than in treating obesity. This is because the energy balance system shows much stronger opposition to weight loss than to weight gain. While large behavior changes are needed to produce and maintain reductions in body weight, small behavior changes may be sufficient to prevent excessive weight gain. In conclusion, the concept of energy balance combined with an understanding of how the body achieves balance may be a useful framework in helping develop strategies to reduce obesity rates. PMID:22753534

  1. Balances instruments, manufacturers, history

    CERN Document Server

    Robens, Erich; Kiefer, Susanne

    2014-01-01

    The book deals mainly with direct mass determination by means of a conventional balances. It covers the history of the balance from the beginnings in Egypt earlier than 3000 BC to recent developments. All balance types are described with emphasis on scientific balances. Methods of indirect mass determination, which are applied to very light objects like molecules and the basic particles of matter and celestial bodies, are included.  As additional guidance, today’s manufacturers are listed and the profile of important companies is reviewed. Several hundred photographs, reproductions and drawings show instruments and their uses. This book includes commercial weighing instruments for merchandise and raw materials in workshops as well as symbolic weighing in the ancient Egyptian’s ceremony of ‘Weighing of the Heart’, the Greek fate balance, the Roman  Justitia, Juno Moneta and Middle Ages scenes of the Last Judgement with Jesus or St. Michael and of modern balances. The photographs are selected from the...

  2. Pro visual C++/CLI and the net 35 platform

    CERN Document Server

    Fraser, Stephen

    2008-01-01

    Pro Visual C++/CLI and the .NET 3.5 Platform is about writing .NET applications using C++/CLI. While readers are learning the ins and outs of .NET application development, they will also be learning the syntax of C++, both old and new to .NET. Readers will also gain a good understanding of the .NET architecture. This is truly a .NET book applying C++ as its development language not another C++ syntax book that happens to cover .NET.

  3. Field-scale water balance closure in seasonally frozen conditions

    Directory of Open Access Journals (Sweden)

    X. Pan

    2017-11-01

    Full Text Available Hydrological water balance closure is a simple concept, yet in practice it is uncommon to measure every significant term independently in the field. Here we demonstrate the degree to which the field-scale water balance can be closed using only routine field observations in a seasonally frozen prairie pasture field site in Saskatchewan, Canada. Arrays of snow and soil moisture measurements were combined with a precipitation gauge and flux tower evapotranspiration estimates. We consider three hydrologically distinct periods: the snow accumulation period over the winter, the snowmelt period in spring, and the summer growing season. In each period, we attempt to quantify the residual between net precipitation (precipitation minus evaporation and the change in field-scale storage (snow and soil moisture, while accounting for measurement uncertainties. When the residual is negligible, a simple 1-D water balance with no net drainage is adequate. When the residual is non-negligible, we must find additional processes to explain the result. We identify the hydrological fluxes which confound the 1-D water balance assumptions during different periods of the year, notably blowing snow and frozen soil moisture redistribution during the snow accumulation period, and snowmelt runoff and soil drainage during the melt period. Challenges associated with quantifying these processes, as well as uncertainties in the measurable quantities, caution against the common use of water balance residuals to estimate fluxes and constrain models in such a complex environment.

  4. Field-scale water balance closure in seasonally frozen conditions

    Science.gov (United States)

    Pan, Xicai; Helgason, Warren; Ireson, Andrew; Wheater, Howard

    2017-11-01

    Hydrological water balance closure is a simple concept, yet in practice it is uncommon to measure every significant term independently in the field. Here we demonstrate the degree to which the field-scale water balance can be closed using only routine field observations in a seasonally frozen prairie pasture field site in Saskatchewan, Canada. Arrays of snow and soil moisture measurements were combined with a precipitation gauge and flux tower evapotranspiration estimates. We consider three hydrologically distinct periods: the snow accumulation period over the winter, the snowmelt period in spring, and the summer growing season. In each period, we attempt to quantify the residual between net precipitation (precipitation minus evaporation) and the change in field-scale storage (snow and soil moisture), while accounting for measurement uncertainties. When the residual is negligible, a simple 1-D water balance with no net drainage is adequate. When the residual is non-negligible, we must find additional processes to explain the result. We identify the hydrological fluxes which confound the 1-D water balance assumptions during different periods of the year, notably blowing snow and frozen soil moisture redistribution during the snow accumulation period, and snowmelt runoff and soil drainage during the melt period. Challenges associated with quantifying these processes, as well as uncertainties in the measurable quantities, caution against the common use of water balance residuals to estimate fluxes and constrain models in such a complex environment.

  5. KONVERGENSI DALAM PROGRAM NET CITIZEN JOURNALISM

    Directory of Open Access Journals (Sweden)

    Rhafidilla Vebrynda

    2017-06-01

    Full Text Available Di dalam artikel ini, peneliti ingin melihat perkembangan teknologi di Indonesia sebagai sebuah peluang untuk menjalankan sebuah program berita berbasis video kiriman masyarakat. Perkembangan teknologi tersebut adalah teknologi penyiaran, teknologi sosial media dan teknologi dalam proses produksi sebuah video. Di Indonesia, jumlah televisi semakin banyak. Setiap stasiun televisi harus bersaing untuk dapat bertahan hidup. Net TV merupakan sebuah stasiun televisi baru di Indonesia yang harus memiliki berbagai program unggulan baru agar dapat bersaing dengan televisi lainnya yang sudah ada. Net TV menggunakan berbagai platform media untuk menjalankan program Net Citizen Journalism (Net CJ. Penggunaan berbagai platform media dikenal dengan istilah multiplatform dan secara teoritis dikenal dengan istilah konvergensi. Konvergensi yaitu saat meleburnya domain-domain dalam berbagai media komunikasi. Artikel ini menggunakan metode studi kasus untuk melihat bagaimana konvergensi terjadi dalam proses pengelolaan program Net CJ. Teknik pengumpulan data adalah dengan wawancara mendalam, observasi dan studi dokumen. Wawancara mendalam dilakukan dari tiga sudut pandang yaitu dari pengelola program, pengguna/audience dan pengamat media. Penelitian ini menemukan bahwa dengan menggunakan berbagai platform media yang fungsinya berbeda, memiliki satu tujuan yang sama yaitu untuk menjalankan program Net CJ. Adapun berbagai platform dalam proses produksi program yaitu tayangan TV konvensional, streaming TV, website, aplikasi Net CJ, facebook, twitter, instagram dan path. Konvergensi media dijalankan dalam dua proses, yaitu proses produksi dan proses promosi program berita.

  6. Net Neutrality: Media Discourses and Public Perception

    Directory of Open Access Journals (Sweden)

    Christine Quail

    2010-01-01

    Full Text Available This paper analyzes media and public discourses surrounding net neutrality, with particular attention to public utility philosophy, from a critical perspective. The article suggests that further public education about net neutrality would be beneficial. The first portion of this paper provides a survey of the existing literature surrounding net neutrality, highlighting the contentious debate between market-based and public interest perspectives. In order to contextualize the debate, an overview of public utility philosophy is provided, shedding light on how the Internet can be conceptualized as a public good. Following this discussion, an analysis of mainstream media is presented, exploring how the media represents the issue of net neutrality and whether or not the Internet is discussed through the lens of public utility. To further examine how the net neutrality debate is being addressed, and to see the potential impacts of media discourses on the general public, the results of a focus group are reported and analyzed. Finally, a discussion assesses the implications of the net neutrality debate as presented through media discourses, highlighting the future of net neutrality as an important policy issue.

  7. Approximation methods for stochastic petri nets

    Science.gov (United States)

    Jungnitz, Hauke Joerg

    1992-01-01

    Stochastic Marked Graphs are a concurrent decision free formalism provided with a powerful synchronization mechanism generalizing conventional Fork Join Queueing Networks. In some particular cases the analysis of the throughput can be done analytically. Otherwise the analysis suffers from the classical state explosion problem. Embedded in the divide and conquer paradigm, approximation techniques are introduced for the analysis of stochastic marked graphs and Macroplace/Macrotransition-nets (MPMT-nets), a new subclass introduced herein. MPMT-nets are a subclass of Petri nets that allow limited choice, concurrency and sharing of resources. The modeling power of MPMT is much larger than that of marked graphs, e.g., MPMT-nets can model manufacturing flow lines with unreliable machines and dataflow graphs where choice and synchronization occur. The basic idea leads to the notion of a cut to split the original net system into two subnets. The cuts lead to two aggregated net systems where one of the subnets is reduced to a single transition. A further reduction leads to a basic skeleton. The generalization of the idea leads to multiple cuts, where single cuts can be applied recursively leading to a hierarchical decomposition. Based on the decomposition, a response time approximation technique for the performance analysis is introduced. Also, delay equivalence, which has previously been introduced in the context of marked graphs by Woodside et al., Marie's method and flow equivalent aggregation are applied to the aggregated net systems. The experimental results show that response time approximation converges quickly and shows reasonable accuracy in most cases. The convergence of Marie's method and flow equivalent aggregation are applied to the aggregated net systems. The experimental results show that response time approximation converges quickly and shows reasonable accuracy in most cases. The convergence of Marie's is slower, but the accuracy is generally better. Delay

  8. Visual Studio 2010 and NET 4 Six-in-One

    CERN Document Server

    Novak, Istvan; Granicz, Adam

    2010-01-01

    Complete coverage of all key .NET 4 and Visual Studio 2010 languages and technologies. .NET 4 is Microsoft's latest version of their core programming platform, and Visual Studio 2010 is the toolset that helps write .NET 4 applications. This comprehensive resource offers one-stop shopping for all you need to know to get productive with .NET 4. Experienced author and .NET guru Mitchel Sellers reviews all the important new features of .NET 4, including .NET charting and ASP.NET charting, ASP.NET dynamic data and jQuery, and the addition of F# as a supported package language. The expansive coverag

  9. The Balance Evaluation Systems Test (BESTest) to Differentiate Balance Deficits

    OpenAIRE

    Horak, Fay B.; Wrisley, Diane M.; Frank, James

    2009-01-01

    Background: Current clinical balance assessment tools do not aim to help therapists identify the underlying postural control systems responsible for poor functional balance. By identifying the disordered systems underlying balance control, therapists can direct specific types of intervention for different types of balance problems.

  10. Chemical processes related to net ozone tendencies in the free troposphere

    Directory of Open Access Journals (Sweden)

    H. Bozem

    2017-09-01

    Full Text Available Ozone (O3 is an important atmospheric oxidant, a greenhouse gas, and a hazard to human health and agriculture. Here we describe airborne in situ measurements and model simulations of O3 and its precursors during tropical and extratropical field campaigns over South America and Europe, respectively. Using the measurements, net ozone formation/destruction tendencies are calculated and compared to 3-D chemistry–transport model simulations. In general, observation-based net ozone tendencies are positive in the continental boundary layer and the upper troposphere at altitudes above  ∼  6 km in both environments. On the other hand, in the marine boundary layer and the middle troposphere, from the top of the boundary layer to about 6–8 km altitude, net O3 destruction prevails. The ozone tendencies are controlled by ambient concentrations of nitrogen oxides (NOx. In regions with net ozone destruction the available NOx is below the threshold value at which production and destruction of O3 balance. While threshold NO values increase with altitude, in the upper troposphere NOx concentrations are generally higher due to the integral effect of convective precursor transport from the boundary layer, downward transport from the stratosphere and NOx produced by lightning. Two case studies indicate that in fresh convective outflow of electrified thunderstorms net ozone production is enhanced by a factor 5–6 compared to the undisturbed upper tropospheric background. The chemistry–transport model MATCH-MPIC generally reproduces the pattern of observation-based net ozone tendencies but mostly underestimates the magnitude of the net tendency (for both net ozone production and destruction.

  11. Chemical processes related to net ozone tendencies in the free troposphere

    Science.gov (United States)

    Bozem, Heiko; Butler, Tim M.; Lawrence, Mark G.; Harder, Hartwig; Martinez, Monica; Kubistin, Dagmar; Lelieveld, Jos; Fischer, Horst

    2017-09-01

    Ozone (O3) is an important atmospheric oxidant, a greenhouse gas, and a hazard to human health and agriculture. Here we describe airborne in situ measurements and model simulations of O3 and its precursors during tropical and extratropical field campaigns over South America and Europe, respectively. Using the measurements, net ozone formation/destruction tendencies are calculated and compared to 3-D chemistry-transport model simulations. In general, observation-based net ozone tendencies are positive in the continental boundary layer and the upper troposphere at altitudes above ˜ 6 km in both environments. On the other hand, in the marine boundary layer and the middle troposphere, from the top of the boundary layer to about 6-8 km altitude, net O3 destruction prevails. The ozone tendencies are controlled by ambient concentrations of nitrogen oxides (NOx). In regions with net ozone destruction the available NOx is below the threshold value at which production and destruction of O3 balance. While threshold NO values increase with altitude, in the upper troposphere NOx concentrations are generally higher due to the integral effect of convective precursor transport from the boundary layer, downward transport from the stratosphere and NOx produced by lightning. Two case studies indicate that in fresh convective outflow of electrified thunderstorms net ozone production is enhanced by a factor 5-6 compared to the undisturbed upper tropospheric background. The chemistry-transport model MATCH-MPIC generally reproduces the pattern of observation-based net ozone tendencies but mostly underestimates the magnitude of the net tendency (for both net ozone production and destruction).

  12. Application and Theory of Petri Nets

    DEFF Research Database (Denmark)

    , the conferences have 150-200 participants, one third of these coming from industry and the rest from universities and research institutions. The 1992 conference was organized by the School of Computing and Management Sciences at Sheffield City Polytechnic, England. The volume contains twoinvited papers, by G......This volume contains the proceedings of the 13th International Conference onApplication and Theory of Petri Nets, held in Sheffield, England, in June 1992. The aim of the Petri net conferences is to create a forum for discussing progress in the application and theory of Petri nets. Typically...

  13. Performance Analysis using Coloured Petri Nets

    DEFF Research Database (Denmark)

    Wells, Lisa Marie

    an explicit separation between modelling the behaviour of a system and monitoring the behaviour of the model. As a result, cleaner and more understandable models can be created. The third paper presents a novel method for adding auxiliary information to coloured Petri net models. Coloured Petri nets models...... in a very limited and predictable manner, and it is easy to enable and disable the auxiliary information. The fourth paper is a case study in which the performance of a web server was analysed using coloured Petri nets. This case study has shown that it is relatively easy to analyse the performance...

  14. The KM3NeT project

    Energy Technology Data Exchange (ETDEWEB)

    Katz, U.F., E-mail: katz@physik.uni-erlangen.d [Erlangen Centre for Astroparticle Physics (ECAP), University of Erlangen-Nuernberg, Erwin-Rommel-Str. 1, 91058 Erlangen (Germany)

    2011-01-21

    The KM3NeT research infrastructure in the deep Mediterranean Sea will host a multi-cubic-kilometre neutrino telescope and provide connectivity for continuous, long-term measurements of earth and sea sciences, such as geology, marine biology and oceanography. The KM3NeT neutrino telescope will complement the IceCube telescope currently being installed at the South Pole in its field of view and surpass its sensitivity by a substantial factor. In this document the major aspects of the KM3NeT technical design are described and the expected physics sensitivity is discussed. Finally, the expected time line towards construction is presented.

  15. The net neutrality debate on Twitter

    Directory of Open Access Journals (Sweden)

    Wolf J. Schünemann

    2015-12-01

    Full Text Available The internet has been seen as a medium that empowers individual political actors in relation to established political elites and media gatekeepers. The present article discusses this “net empowerment hypothesis” and tests it empirically by analysing Twitter communication on the regulation of net neutrality. We extracted 503.839 tweets containing #NetNeutrality posted between January and March 2015 and analysed central developments and the network structure of the debate. The empirical results show that traditional actors from media and politics still maintain a central role.

  16. Kisspeptin and energy balance in reproduction.

    Science.gov (United States)

    De Bond, Julie-Ann P; Smith, Jeremy T

    2014-03-01

    Kisspeptin is vital for the neuroendocrine regulation of GNRH secretion. Kisspeptin neurons are now recognized as a central pathway responsible for conveying key homeostatic information to GNRH neurons. This pathway is likely to mediate the well-established link between energy balance and reproductive function. Thus, in states of severely altered energy balance (either negative or positive), fertility is compromised, as is Kiss1 expression in the arcuate nucleus. A number of metabolic modulators have been proposed as regulators of kisspeptin neurons including leptin, ghrelin, pro-opiomelanocortin (POMC), and neuropeptide Y (NPY). Whether these regulate kisspeptin neurons directly or indirectly will be discussed. Moreover, whether the stimulatory role of leptin on reproduction is mediated by kisspeptin directly will be questioned. Furthermore, in addition to being expressed in GNRH neurons, the kisspeptin receptor (Kiss1r) is also expressed in other areas of the brain, as well as in the periphery, suggesting alternative roles for kisspeptin signaling outside of reproduction. Interestingly, kisspeptin neurons are anatomically linked to, and can directly excite, anorexigenic POMC neurons and indirectly inhibit orexigenic NPY neurons. Thus, kisspeptin may have a direct role in regulating energy balance. Although data from Kiss1r knockout and WT mice found no differences in body weight, recent data indicate that kisspeptin may still play a role in food intake and glucose homeostasis. Thus, in addition to regulating reproduction, and mediating the effect of energy balance on reproductive function, kisspeptin signaling may also be a direct regulator of metabolism.

  17. Net Zero Energy Military Installations: A Guide to Assessment and Planning

    Energy Technology Data Exchange (ETDEWEB)

    Booth, S.; Barnett, J.; Burman, K.; Hambrick, J.; Westby, R.

    2010-08-01

    The U.S. Department of Defense (DoD) recognizes the strategic importance of energy to its mission, and is working to reduce energy consumption and enhance energy self-sufficiency by drawing on local clean energy sources. A joint initiative formed between DoD and the U.S. Department of Energy (DOE) in 2008 to address military energy use led to a task force to examine the potential for net zero energy military installations, which would produce as much energy on site as they consume in buildings, facilities, and fleet vehicles. This report presents an assessment and planning process to examine military installations for net zero energy potential. Net Zero Energy Installation Assessment (NZEIA) presents a systematic framework to analyze energy projects at installations while balancing other site priorities such as mission, cost, and security.

  18. Net-Zero-Energy Model for Sustainable Wastewater Treatment.

    Science.gov (United States)

    Yan, Peng; Qin, Rong-Cong; Guo, Jin-Song; Yu, Qiang; Li, Zhe; Chen, You-Peng; Shen, Yu; Fang, Fang

    2017-01-17

    A large external energy input prevents wastewater treatment from being environmentally sustainable. A net-zero-energy (NZE) wastewater treatment concept based on biomass energy recycling was proposed to avoid wasting resources and to promote energy recycling in wastewater treatment plants (WWTPs). Simultaneously, a theoretical model and boundary condition based on energy balance were established to evaluate the feasibility of achieving NZE in WWTPs; the model and condition were employed to analyze data from 20 conventional WWTPs in China. A total of six WWTPs can currently export excess energy, eight WWTPs can achieve 100% energy self-sufficiency by adjusting the metabolic material allocation, and six municipal WWTPs cannot achieve net-zero energy consumption based on the evaluation of the theoretical model. The NZE model offset 79.5% of the electricity and sludge disposal cost compared with conventional wastewater treatment. The NZE model provides a theoretical basis for the optimization of material regulation for the effective utilization of organic energy from wastewater and promotes engineering applications of the NZE concept in WWTPs.

  19. Natural calcium isotonic composition of urine as a marker of bone mineral balance

    Science.gov (United States)

    Skulan, J.; Bullen, T.; Anbar, A.D.; Puzas, J.E.; Shackelford, L.; LeBlanc, A.; Smith, S.M.

    2007-01-01

    Background: We investigated whether changes in the natural isotopic composition of calcium in human urine track changes in net bone mineral balance, as predicted by a model of calcium isotopic behavior in vertebrates. If so, isotopic analysis of natural urine or blood calcium could be used to monitor short-term changes in bone mineral balance that cannot be detected with other techniques. Methods: Calcium isotopic compositions are expressed as ??44Ca, or the difference in parts per thousand between the 44Ca/40Ca of a sample and the 44Ca/ 40Ca of a standard reference material. ??44Ca was measured in urine samples from 10 persons who participated in a study of the effectiveness of countermeasures to bone loss in spaceflight, in which 17 weeks of bed rest was used to induce bone loss. Study participants were assigned to 1 of 3 treatment groups: controls received no treatment, one treatment group received alendronate, and another group performed resistive exercise. Measurements were made on urine samples collected before, at 2 or 3 points during, and after bed rest. Results: Urine ??44Ca values during bed rest were lower in controls than in individuals treated with alendronate (P clinical and research tool. ?? 2007 American Association for Clinical Chemistry.

  20. Planning long lasting insecticide treated net campaigns: should households' existing nets be taken into account?

    Science.gov (United States)

    Yukich, Joshua; Bennett, Adam; Keating, Joseph; Yukich, Rudy K; Lynch, Matt; Eisele, Thomas P; Kolaczinski, Kate

    2013-06-14

    Mass distribution of long-lasting insecticide treated bed nets (LLINs) has led to large increases in LLIN coverage in many African countries. As LLIN ownership levels increase, planners of future mass distributions face the challenge of deciding whether to ignore the nets already owned by households or to take these into account and attempt to target individuals or households without nets. Taking existing nets into account would reduce commodity costs but require more sophisticated, and potentially more costly, distribution procedures. The decision may also have implications for the average age of nets in use and therefore on the maintenance of universal LLIN coverage over time. A stochastic simulation model based on the NetCALC algorithm was used to determine the scenarios under which it would be cost saving to take existing nets into account, and the potential effects of doing so on the age profile of LLINs owned. The model accounted for variability in timing of distributions, concomitant use of continuous distribution systems, population growth, sampling error in pre-campaign coverage surveys, variable net 'decay' parameters and other factors including the feasibility and accuracy of identifying existing nets in the field. Results indicate that (i) where pre-campaign coverage is around 40% (of households owning at least 1 LLIN), accounting for existing nets in the campaign will have little effect on the mean age of the net population and (ii) even at pre-campaign coverage levels above 40%, an approach that reduces LLIN distribution requirements by taking existing nets into account may have only a small chance of being cost-saving overall, depending largely on the feasibility of identifying nets in the field. Based on existing literature the epidemiological implications of such a strategy is likely to vary by transmission setting, and the risks of leaving older nets in the field when accounting for existing nets must be considered. Where pre-campaign coverage

  1. Planning long lasting insecticide treated net campaigns: should households’ existing nets be taken into account?

    Science.gov (United States)

    2013-01-01

    Background Mass distribution of long-lasting insecticide treated bed nets (LLINs) has led to large increases in LLIN coverage in many African countries. As LLIN ownership levels increase, planners of future mass distributions face the challenge of deciding whether to ignore the nets already owned by households or to take these into account and attempt to target individuals or households without nets. Taking existing nets into account would reduce commodity costs but require more sophisticated, and potentially more costly, distribution procedures. The decision may also have implications for the average age of nets in use and therefore on the maintenance of universal LLIN coverage over time. Methods A stochastic simulation model based on the NetCALC algorithm was used to determine the scenarios under which it would be cost saving to take existing nets into account, and the potential effects of doing so on the age profile of LLINs owned. The model accounted for variability in timing of distributions, concomitant use of continuous distribution systems, population growth, sampling error in pre-campaign coverage surveys, variable net ‘decay’ parameters and other factors including the feasibility and accuracy of identifying existing nets in the field. Results Results indicate that (i) where pre-campaign coverage is around 40% (of households owning at least 1 LLIN), accounting for existing nets in the campaign will have little effect on the mean age of the net population and (ii) even at pre-campaign coverage levels above 40%, an approach that reduces LLIN distribution requirements by taking existing nets into account may have only a small chance of being cost-saving overall, depending largely on the feasibility of identifying nets in the field. Based on existing literature the epidemiological implications of such a strategy is likely to vary by transmission setting, and the risks of leaving older nets in the field when accounting for existing nets must be considered

  2. Improvements to water use and water stress estimates with the addition of IR and net radiometers to weather stations

    Science.gov (United States)

    Evapotranspiration (ET) is often estimated with the Penman-Monteith (P-M) equation. Net radiation (Rn) is a major component of the surface energy balance and an input to the P-M equation, but it is challenging and expensive to measure accurately. For these reasons, most weather stations do not inclu...

  3. UV sensitivity of planktonic net community production in ocean surface waters

    Science.gov (United States)

    Regaudie-de-Gioux, Aurore; Agustí, Susana; Duarte, Carlos M.

    2014-05-01

    The net plankton community metabolism of oceanic surface waters is particularly important as it more directly affects the partial pressure of CO2 in surface waters and thus the air-sea fluxes of CO2. Plankton communities in surface waters are exposed to high irradiance that includes significant ultraviolet blue (UVB, 280-315 nm) radiation. UVB radiation affects both photosynthetic and respiration rates, increase plankton mortality rates, and other metabolic and chemical processes. Here we test the sensitivity of net community production (NCP) to UVB of planktonic communities in surface waters across contrasting regions of the ocean. We observed here that UVB radiation affects net plankton community production at the ocean surface, imposing a shift in NCP by, on average, 50% relative to the values measured when excluding partly UVB. Our results show that under full solar radiation, the metabolic balance shows the prevalence of net heterotrophic community production. The demonstration of an important effect of UVB radiation on NCP in surface waters presented here is of particular relevance in relation to the increased UVB radiation derived from the erosion of the stratospheric ozone layer. Our results encourage design future research to further our understanding of UVB effects on the metabolic balance of plankton communities.

  4. Generating a positive energy balance from using rice straw for anaerobic digestion

    Directory of Open Access Journals (Sweden)

    V.H. Nguyen

    2016-11-01

    The net energy of the rice straw supply chain for biogas generation through AD is 3,500 MJ per ton of straw. This rice straw management option can provide a 70% net output energy benefit. The research highlighted the potential of rice straw as a clean fuel source with a positive energy balance, helping to reduce greenhouse gas emissions compared with the existing practice of burning it in the field.

  5. The Balanced Company

    DEFF Research Database (Denmark)

    Controlling the sustainability of production processes and ethical employment of the work force in suppliers' production facilities far away from the home country has resulted in new challenges for managers. They now have to consider how important it is for customers, investors and employees to see...... that a company is respected in wider society and behaves according to ethical standards. Strategists and Leaders need to make balanced choices about long-term goals and the allocation of resources. They need to analyse, understand and adjust strategies to market, political, value and technology related changes...... through control or trust. Human resource specialists need to make balanced decisions about how to design tasks and jobs in order to make them attractive as well as motivating. Marketers need to make balanced decisions about how to market products in the light of what is now important in consumers...

  6. Extraordinary hall balance

    Science.gov (United States)

    Zhang, S. L.; Liu, Y.; Collins-McIntyre, L. J.; Hesjedal, T.; Zhang, J. Y.; Wang, S. G.; Yu, G. H.

    2013-01-01

    Magnetoresistance (MR) effects are at the heart of modern information technology. However, future progress of giant and tunnelling MR based storage and logic devices is limited by the usable MR ratios of currently about 200% at room-temperature. Colossal MR structures, on the other hand, achieve their high MR ratios of up to 106% only at low temperatures and high magnetic fields. We introduce the extraordinary Hall balance (EHB) and demonstrate room-temperature MR ratios in excess of 31,000%. The new device concept exploits the extraordinary Hall effect in two separated ferromagnetic layers with perpendicular anisotropy in which the Hall voltages can be configured to be carefully balanced or tipped out of balance. Reprogrammable logic and memory is realised using a single EHB element. PACS numbers: 85.75.Nn,85.70.Kh,72.15.Gd,75.60.Ej. PMID:23804036

  7. Sport-specific balance.

    Science.gov (United States)

    Zemková, Erika

    2014-05-01

    This review includes the latest findings based on experimental studies addressing sport-specific balance, an area of research that has grown dramatically in recent years. The main objectives of this work were to investigate the postural sway response to different forms of exercise under laboratory and sport-specific conditions, to examine how this effect can vary with expertise, and to provide examples of the association of impaired balance with sport performance and/or increasing risk of injury. In doing so, sports where body balance is one of the limiting factors of performance were analyzed. While there are no significant differences in postural stability between athletes of different specializations and physically active individuals during standing in a standard upright position (e.g., bipedal stance), they have a better ability to maintain balance in specific conditions (e.g., while standing on a narrow area of support). Differences in magnitude of balance impairment after specific exercises (rebound jumps, repeated rotations, etc.) and mainly in speed of its readjustment to baseline are also observed. Besides some evidence on an association of greater postural sway with the increasing risk of injuries, there are many myths related to the negative influence of impaired balance on sport performance. Though this may be true for shooting or archery, findings have shown that in many other sports, highly skilled athletes are able to perform successfully in spite of increased postural sway. These findings may contribute to better understanding of the postural control system under various performance requirements. It may provide useful knowledge for designing training programs for specific sports.

  8. RadNet Air Quality (Deployable) Data

    Data.gov (United States)

    U.S. Environmental Protection Agency — RadNet Deployable Monitoring is designed to collect radiological and meteorological information and data asset needed to establish the impact of radiation levels on...

  9. A Lightweight TwiddleNet Portal

    National Research Council Canada - National Science Library

    Rimikis, Antonios M

    2008-01-01

    TwiddleNet is a distributed architecture of personal servers that harnesses the power of the mobile devices, enabling real time information and file sharing of multiple data types from commercial-off-the-shelf platforms...

  10. Homology Groups of a Pipeline Petri Net

    Directory of Open Access Journals (Sweden)

    A. A. Husainov

    2013-01-01

    Full Text Available Petri net is said to be elementary if every place can contain no more than one token. In this paper, it is studied topological properties of the elementary Petri net for a pipeline consisting of n functional devices. If the work of the functional devices is considered continuous, we can come to some topological space of “intermediate” states. In the paper, it is calculated the homology groups of this topological space. By induction on n, using the Addition Sequence for homology groups of semicubical sets, it is proved that in dimension 0 and 1 the integer homology groups of these nets are equal to the group of integers, and in the remaining dimensions are zero. Directed homology groups are studied. A connection of these groups with deadlocks and newsletters is found. This helps to prove that all directed homology groups of the pipeline elementary Petri nets are zeroth.

  11. Balancing through episodic learning

    DEFF Research Database (Denmark)

    Scheuer, John Damm

    2013-01-01

    Peter Jarvis’s theory about learning suggests that human beings learn and change as a result of hearing, seeing, smelling, tasting, touching, and feeling. They change and learn by interacting with other humans, things, and events in certain time-space contexts and by reflecting upon these, as well...... as upon wished-for future states or past experiences, knowledge, and history, and upon what these experiences mean to one’s own self and identity. This chapter explores how female top managers have to reflect and find a balance in their work-family lives on the basis of interaction with, and inputs from...... being in a state of balance....

  12. Application of Balanced Scorecard

    OpenAIRE

    Barej, Lukáš

    2015-01-01

    The concept of the Balanced Scorecard taking a part in the strategic management of a company, is a main focus of this thesis. There are the theoretical and methodological parts of the Balanced Scorecard characterized individually, as well as the development and the history of this concept. This thesis is dealing with a draft of the practical implementation of the mentioned methods. The practical part of the thesis is following the theoretical introduction where the practical part is focused o...

  13. In the balance

    DEFF Research Database (Denmark)

    Kluth, Michael Friederich; Pilegaard, Jess

    The present paper seeks to make sense of recent EU naval capability changes by applying neo-realist theory on the EU as an international actor in the global balance of power. The paper compares three different strands of Neo-realist theory by deducting key predictions about the expected defense...... posture of the Union and the expected changes in naval capabilities. The predictions are subsequently held up against recent data on naval military build-up in the EU. The paper argues that the observed patterns are best explained not as bandwagoning with the United States, but as a long-term balancing...

  14. Finding Your Balance

    CERN Document Server

    (CCL), Center for Creative Leadership; Patterson, Gordon

    2011-01-01

    Balance isn't an issue of time, but an issue of choice. It's about living your values by aligning your behavior with what you believe is really important. Aligning your behavior with your values is much like any other developmental experience; the basic process involves assessment, challenge, and support. You need to determine where you are, define where you want to go, and then put into place the tools you need to get there.Balance is about more than how you spend your time. It's about how you live your life. It's about recognizing that you have control over the choices you make and aligning

  15. CDMA and TDMA based neural nets.

    Science.gov (United States)

    Herrero, J C

    2001-06-01

    CDMA and TDMA telecommunication techniques were established long time ago, but they have acquired a renewed presence due to the rapidly increasing mobile phones demand. In this paper, we are going to see they are suitable for neural nets, if we leave the concept "connection" between processing units and we adopt the concept "messages" exchanged between them. This may open the door to neural nets with a higher number of processing units and flexible configuration.

  16. Mastering AngularJD for .NET developers

    CERN Document Server

    Majid, Mohammad Wadood

    2015-01-01

    This book is envisioned for traditional developers and programmers who want to develop client-side applications using the AngularJS framework and ASP.NET Web API 2 with Visual Studio. .NET developers who have already built web applications or web services and who have a fundamental knowledge of HTML, JavaScript, and CSS and want to explore single-page applications will also find this guide useful. Basic knowledge of AngularJS would be helpful.

  17. .NET 4.5 parallel extensions

    CERN Document Server

    Freeman, Bryan

    2013-01-01

    This book contains practical recipes on everything you will need to create task-based parallel programs using C#, .NET 4.5, and Visual Studio. The book is packed with illustrated code examples to create scalable programs.This book is intended to help experienced C# developers write applications that leverage the power of modern multicore processors. It provides the necessary knowledge for an experienced C# developer to work with .NET parallelism APIs. Previous experience of writing multithreaded applications is not necessary.

  18. A Lightweight TwiddleNet Portal

    Science.gov (United States)

    2008-03-01

    designed to exploit the multiple networking modalities available in the current generation of smartphones . TwiddleNet enables well-organized and well...of Sonopia and will have a comprehensive review of the service in the coming weeks [12]. Twango, which was acquired by Nokia in July 2007, is an...EXPERIMENTATION As already mentioned the main purpose of this thesis is the development of a TwiddleNet portal running on a smartphone or a PDA, which can allow

  19. CCS - and its relationship to net theory

    DEFF Research Database (Denmark)

    Nielsen, Mogens

    1987-01-01

    In this paper we give a short introduction to Milner's Calculus for Communicating Systems - a paradigm for concurrent computation. We put special emphasis on the basic concepts and tools from the underlying "algebraic approach", and their relationship to the approach to concurrency within net...... theory. Furthermore, we provide an operational version of the language CCS with "true concurrency" in the sense of net theory, and a discussion of the possible use of such a marriage of the two theories of concurrency....

  20. Neutrophil NETs in reproduction: from infertility to preeclampsia and the possibility of fetal loss

    Directory of Open Access Journals (Sweden)

    Sinuhe eHahn

    2012-11-01

    Full Text Available The intention of this review is to provide an overview of the potential role of neutrophil extracellular traps (NETs in mammalian reproduction. Neutrophil NETs appear to be involved in various stages of the reproductive cycle, starting with fertility and possibly ending with fetal loss. The first suggestion that NETs may play a role in pregnancy-related disorders was in preeclampsia, where vast numbers were detected in the intervillous space of affected placentae. The induction of NETosis involved an auto-inflammatory component, mediated by the increased release of placental micro-debris in preeclampsia. This report was the first indicating that NETs may be associated with a human pathology not involving infection.Subsequently, NETs have since then been implicated in bovine or equine infertility, in that semen may become entrapped in the female reproductive during their passage to the oocyte. In this instance interesting species-specific differences are apparent, in that equine sperm evade entrapment via expression of a DNAse-like molecule, whereas highly motile bovine sperm, once free from seminal plasma that promotes interaction with neutrophils, appear impervious to NETs entrapment.Although still in the realm of speculation it is plausible that NETs may be involved in recurrent fetal loss mediated by anti-phospholipid antibodies, or perhaps even in fetal abortion triggered by infections with microorganisms such as L. monocytogenes or B. abortus.

  1. Visual Studio 2013 and .NET 4.5 expert cookbook

    CERN Document Server

    Sur, Abhishek

    2014-01-01

    If you are a Visual Studio 2013 or .NET developer who would like to sharpen your existing skill set and adapt to new .NET technologies, this is the book for you. A basic understanding of .NET and C# is required.

  2. HANPP Collection: Global Patterns in Net Primary Productivity (NPP)

    Data.gov (United States)

    National Aeronautics and Space Administration — The Global Patterns in Net Primary Productivity (NPP) portion of the Human Appropriation of Net Primary Productivity (HANPP) Collection maps the net amount of solar...

  3. Experimental results on air permeability of agricultural nets

    Directory of Open Access Journals (Sweden)

    Sergio Castellano

    2016-09-01

    Full Text Available In order to evaluate the influence of the texture characteristics of agricultural nets on the air flow passing through them, a micro wind tunnel was designed and built in the testing and engineering laboratory of Sachim s.r.l., an Italian high-density polyethylene (HDPE technical textiles manufacturer. The micro wind tunnel (0.1345 m diameter allowed the simultaneous measurement of the air flowrate and the pressure drop through a net sample. The equipment was designed to set up the inclination of the net samples with respect of the airflow at fixed angles (90°, 60°, 45°, 30°. The variation of the pressure drop with the air velocity on four different flat woven round monofilament HDPE nets perpendicular to the air flow are here reported. In all cases the air velocity measured into the micro wind tunnel was above 4 m s–1 hence reported results do not consider low wind speed. Preliminarily, the loss coefficient was assumed as a function of porosity and Reynolds number, calculated with reference to the equivalent diameter of the pores, FS(Rel,ε and showed percent deviations form experimental results in the range 14.6%÷25.3%. Hence a simplified expression of the loss coefficient, depending only on the porosity was proposed, FS(ε which highlighted differences with experimental results in the range 3.5%÷20.3%. Finally, results were compared with those based on the Bernoulli’s principle found in the literature.

  4. A Cellular Approach to Net-Zero Energy Cities

    Directory of Open Access Journals (Sweden)

    Miguel Amado

    2017-11-01

    Full Text Available Recent growth in the use of photovoltaic technology and a rapid reduction in its cost confirms the potential of solar power on a large scale. In this context, planning for the deployment of smart grids is among the most important challenges to support the increased penetration of solar energy in urban areas and to ensure the resilience of the electricity system. As part this effort, the present paper describes a cellular approach to a Net-Zero energy concept, based on the balance between the potential solar energy supply and the existing consumption patterns at the urban unit scale. To do that, the Geographical Urban Units Delimitation model (GUUD has been developed and tested on a case study. By applying the GUUD model, which combines Geographic Information Systems (GIS, parametric modelling, and solar dynamic analysis, the whole area of the city was divided into urban cells, categorized as solar producers and energy consumers. The discussion around three theoretical scenarios permits us to explore how smart grids can be approached and promoted from an urban planning perspective. The paper provides insights into how urban planning can be a driver to optimize and manage energy balance across the city if the deployment of smart grids is correctly integrated in its operative process.

  5. Toward Balance in Translation.

    Science.gov (United States)

    Costello, Nancy A.

    A study compared translations of biblical passages into different languages in Papua New Guinea. The study looked for evidence of balance between literal and free interpretation in translation style in the gospel of Mark, which is narrative and didactic material, in 12 languages, and the mainly hortatory genre in translations of 4 epistles:…

  6. The Heider Balance:

    Science.gov (United States)

    Kułakowski, Krzysztof; Gawroński, Przemysław; Gronek, Piotr

    The Heider balance (HB) is investigated in a fully connected graph of N nodes. The links are described by a real symmetric array r (i, j), i, j =1, …, N. In a social group, nodes represent group members and links represent relations between them, positive (friendly) or negative (hostile). At the balanced state, r (i, j) r (j, k) r (k, i) > 0 for all the triads (i, j, k). As follows from the structure theorem of Cartwright and Harary, at this state the group is divided into two subgroups, with friendly internal relations and hostile relations between the subgroups. Here the system dynamics is proposed to be determined by a set of differential equations, ˙ r =rḑot r. The form of equations guarantees that once HB is reached, it persists. Also, for N =3 the dynamics reproduces properly the tendency of the system to the balanced state. The equations are solved numerically. Initially, r (i, j) are random numbers distributed around zero with a symmetric uniform distribution of unit width. Calculations up to N =500 show that HB is always reached. Time τ(N) to get the balanced state varies with the system size N as N-1/2. The spectrum of relations, initially narrow, gets very wide near HB. This means that the relations are strongly polarized. In our calculations, the relations are limited to a given range around zero. With this limitation, our results can be helpful in an interpretation of some statistical data.

  7. Balancing Trust and Control

    DEFF Research Database (Denmark)

    Jagd, Søren

    2010-01-01

    The purpose of this paper is to show that conceptualizing trust and control as interactively related processes, as opposed to more static conceptualizations of the two concepts and the relations between them, adds importantly towards understanding the challenges involved in balancing of trust and...

  8. Balancing Trust and Control

    DEFF Research Database (Denmark)

    Jagd, Søren

    This paper focuses on the leadership challenge of balancing trust and control. The relation between trust and control has for a long time been a puzzling issue for management researchers. In the paper I first show that there has been a dramatic change in the way the relation between trust and con...

  9. Balancing trust and power

    DEFF Research Database (Denmark)

    Broholm-Jørgensen, Marie; Guassora, Ann Dorrit; Reventlow, Susanne

    2017-01-01

    of clinical encounters. Results: From the empirical data, we identified three dimensions of respect: respect for the patient’s autonomy, respect for professional authority and respect as a mutual exchange. A balance of respect influenced trust in the relationship between GP and patients and the transfer...

  10. Balance of Power

    NARCIS (Netherlands)

    Boone, J.

    2004-01-01

    This paper argues that the efficiency distribution of players in a game determines how aggressively these players interact.We formalize the idea of balance of power: players fight very inefficient players but play softly versus equally (or more) efficient players.This theory of conduct predicts that

  11. Strategic Balanced Scorecard Simulation

    DEFF Research Database (Denmark)

    Nielsen, Steen; Nielsen, Erland Hejn

    2012-01-01

    The purpose of this article is to show how a System Dynamics Modelling approach can be integrated into the Balanced Scorecard (BSC) for a case company with special focus on the handling of causality in a dynamic perspective. The case company’s BSC model includes five perspectives and a number...

  12. Lives in the Balance.

    Science.gov (United States)

    Our Children, 1997

    1997-01-01

    Changes in the workplace that would provide flexibility for working parents are slowly developing and receiving government, business, and societal attention. A sidebar, "Mother, Professional, Volunteer: One Woman's Balancing Act," presents an account of how one woman rearranged her professional life to enable her to do full-time…

  13. ASP.NET web API build RESTful web applications and services on the .NET framework

    CERN Document Server

    Kanjilal, Joydip

    2013-01-01

    This book is a step-by-step, practical tutorial with a simple approach to help you build RESTful web applications and services on the .NET framework quickly and efficiently.This book is for ASP.NET web developers who want to explore REST-based services with C# 5. This book contains many real-world code examples with explanations whenever necessary. Some experience with C# and ASP.NET 4 is expected.

  14. Freeze-out conditions from net-proton and net-charge fluctuations at RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Alba, Paolo; Alberico, Wanda [Department of Physics, Torino University and INFN, Sezione di Torino, via P. Giuria 1, 10125 Torino (Italy); Bellwied, Rene [Department of Physics, University of Houston, Houston, TX 77204 (United States); Bluhm, Marcus [Department of Physics, Torino University and INFN, Sezione di Torino, via P. Giuria 1, 10125 Torino (Italy); Department of Physics, North Carolina State University, Raleigh, NC 27695 (United States); Mantovani Sarti, Valentina [Department of Physics, Torino University and INFN, Sezione di Torino, via P. Giuria 1, 10125 Torino (Italy); Nahrgang, Marlene [Department of Physics, Duke University, Durham, NC 27708-0305 (United States); Frankfurt Institute for Advanced Studies (FIAS), Ruth-Moufang-Str. 1, 60438 Frankfurt am Main (Germany); Ratti, Claudia [Department of Physics, Torino University and INFN, Sezione di Torino, via P. Giuria 1, 10125 Torino (Italy)

    2014-11-10

    We calculate ratios of higher-order susceptibilities quantifying fluctuations in the number of net-protons and in the net-electric charge using the Hadron Resonance Gas (HRG) model. We take into account the effect of resonance decays, the kinematic acceptance cuts in rapidity, pseudo-rapidity and transverse momentum used in the experimental analysis, as well as a randomization of the isospin of nucleons in the hadronic phase. By comparing these results to the latest experimental data from the STAR Collaboration, we determine the freeze-out conditions from net-electric charge and net-proton distributions and discuss their consistency.

  15. MetNet: Software to Build and Model the Biogenetic Lattice of Arabidopsis

    Directory of Open Access Journals (Sweden)

    Heike Hofmann

    2006-04-01

    Full Text Available MetNet (http://www.botany.iastate.edu/∼mash/metnetex/metabolicnetex.html is publicly available software in development for analysis of genome-wide RNA, protein and metabolite profiling data. The software is designed to enable the biologist to visualize, statistically analyse and model a metabolic and regulatory network map of Arabidopsis, combined with gene expression profiling data. It contains a JAVA interface to an interactions database (MetNetDB containing information on regulatory and metabolic interactions derived from a combination of web databases (TAIR, KEGG, BRENDA and input from biologists in their area of expertise. FCModeler captures input from MetNetDB in a graphical form. Sub-networks can be identified and interpreted using simple fuzzy cognitive maps. FCModeler is intended to develop and evaluate hypotheses, and provide a modelling framework for assessing the large amounts of data captured by high-throughput gene expression experiments. FCModeler and MetNetDB are currently being extended to three-dimensional virtual reality display. The MetNet map, together with gene expression data, can be viewed using multivariate graphics tools in GGobi linked with the data analytic tools in R. Users can highlight different parts of the metabolic network and see the relevant expression data highlighted in other data plots. Multi-dimensional expression data can be rotated through different dimensions. Statistical analysis can be computed alongside the visual. MetNet is designed to provide a framework for the formulation of testable hypotheses regarding the function of specific genes, and in the long term provide the basis for identification of metabolic and regulatory networks that control plant composition and development.

  16. Net community production in the bottom of first-year sea ice over the Arctic spring bloom

    Science.gov (United States)

    Campbell, K.; Mundy, C. J.; Gosselin, M.; Landy, J. C.; Delaforge, A.; Rysgaard, S.

    2017-09-01

    The balance of photosynthesis and respiration by organisms like algae and bacteria determines whether sea ice is net heterotrophic or autotrophic. In turn this clarifies the influence of microbes on atmosphere-ice-ocean gas fluxes and their contribution to the trophic system. In this study we define two phases of the spring bloom based on bottom ice net community production and algal growth. Phase I was characterized by limited algal accumulation and low productivity, which at times resulted in net heterotrophy. Greater productivity in Phase II drove rapid algal accumulation that consistently produced net autotrophic conditions. The different phases were associated with seasonal shifts in light availability and species dominance. Results from this study demonstrate the importance of community respiration on spring productivity, as respiration rates can maintain a heterotrophic state independent of algal growth. This challenges previous assumptions of a fully autotrophic sea ice community during the ice-covered spring.

  17. Net clinical benefit of new oral anticoagulants (dabigatran, rivaroxaban, apixaban) versus no treatment in a 'real world' atrial fibrillation population

    DEFF Research Database (Denmark)

    Banerjee, A; Lane, D A; Torp-Pedersen, C

    2012-01-01

    on patients with non-valvular AF between 1997-2008, for dabigatran, rivaroxaban and apixaban on the basis of recent clinical trial outcome data for these new OACs. In patients with CHADS2=0 but at high bleeding risk, apixaban and dabigatran 110 mg bid had a positive net clinical benefit. At CHA2DS2-VASc=1...... risk of stroke and thromboembolism gain the greatest benefit from OAC with warfarin. There are no data for the new OACs, that is, dabigatran, rivaroxaban and apixaban, as yet. We calculated the net clinical benefit balancing IS against ICH using data from the Danish National Patient Registry......, apixaban and both doses of dabigatran (110 mg and 150 mg bid) had a positive net clinical benefit. In patients with CHADS2 score=1 or CHA2DS2-VASc=2, the three new OACs (dabigatran, rivaroxaban and apixaban) appear superior to warfarin for net clinical benefit, regardless of risk of bleeding. When risk...

  18. Characterization of NvLWamide-like neurons reveals stereotypy in Nematostella nerve net development.

    Science.gov (United States)

    Havrilak, Jamie A; Faltine-Gonzalez, Dylan; Wen, Yiling; Fodera, Daniella; Simpson, Ayanna C; Magie, Craig R; Layden, Michael J

    2017-11-15

    The organization of cnidarian nerve nets is traditionally described as diffuse with randomly arranged neurites that show minimal reproducibility between animals. However, most observations of nerve nets are conducted using cross-reactive antibodies that broadly label neurons, which potentially masks stereotyped patterns produced by individual neuronal subtypes. Additionally, many cnidarians species have overt structures such as a nerve ring, suggesting higher levels of organization and stereotypy exist, but mechanisms that generated that stereotypy are unknown. We previously demonstrated that NvLWamide-like is expressed in a small subset of the Nematostella nerve net and speculated that observing a few neurons within the developing nerve net would provide a better indication of potential stereotypy. Here we document NvLWamide-like expression more systematically. NvLWamide-like is initially expressed in the typical neurogenic salt and pepper pattern within the ectoderm at the gastrula stage, and expression expands to include endodermal salt and pepper expression at the planula larval stage. Expression persists in both ectoderm and endoderm in adults. We characterized our NvLWamide-like::mCherry transgenic reporter line to visualize neural architecture and found that NvLWamide-like is expressed in six neural subtypes identifiable by neural morphology and location. Upon completing development the numbers of neurons in each neural subtype are minimally variable between animals and the projection patterns of each subtype are consistent. Furthermore, between the juvenile polyp and adult stages the number of neurons for each subtype increases. We conclude that development of the Nematostella nerve net is stereotyped between individuals. Our data also imply that one aspect of generating adult cnidarian nervous systems is to modify the basic structural architecture generated in the juvenile by increasing neural number proportionally with size. Copyright © 2017 The Authors

  19. Re(De)fining Net Zero Energy: Renewable Emergy Balance in Environmental Building Design

    Science.gov (United States)

    The notion that raw materials for building construction are plentiful and can be extracted “at will” from Earth’s geobiosphere, and that these materials do not undergo any degradation or related deterioration in performance while in use is alarming and entirely inaccurate. For th...

  20. Purex Operation - material balance and net production report, July 1964 - Fiscal Year 1965

    Energy Technology Data Exchange (ETDEWEB)

    Burge, W.L.

    1964-08-12

    This report is an inventory record of materials which were received and shipped from the Purex Process during this time period. Material accounting includes uranium, uranium-235, plutonium, and other transuranics.

  1. CellNet: network biology applied to stem cell engineering.

    Science.gov (United States)

    Cahan, Patrick; Li, Hu; Morris, Samantha A; Lummertz da Rocha, Edroaldo; Daley, George Q; Collins, James J

    2014-08-14

    Somatic cell reprogramming, directed differentiation of pluripotent stem cells, and direct conversions between differentiated cell lineages represent powerful approaches to engineer cells for research and regenerative medicine. We have developed CellNet, a network biology platform that more accurately assesses the fidelity of cellular engineering than existing methodologies and generates hypotheses for improving cell derivations. Analyzing expression data from 56 published reports, we found that cells derived via directed differentiation more closely resemble their in vivo counterparts than products of direct conversion, as reflected by the establishment of target cell-type gene regulatory networks (GRNs). Furthermore, we discovered that directly converted cells fail to adequately silence expression programs of the starting population and that the establishment of unintended GRNs is common to virtually every cellular engineering paradigm. CellNet provides a platform for quantifying how closely engineered cell populations resemble their target cell type and a rational strategy to guide enhanced cellular engineering. Copyright © 2014 Elsevier Inc. All rights reserved.

  2. IMPLIKATUR WACANA HUMOR GELAR WICARA INI TALKSHOW DI NET TV

    Directory of Open Access Journals (Sweden)

    Nur Irfansyah

    2017-04-01

    Full Text Available The goal reached in this study is to describe and explain (1 implicature entity; (2 violation of cooperative principle; and (3 violation of politeness principle. The research is qualitative approach in content analysis and pragmatics theory designed. Data is humor discourse on Ini Talkshow program at NET TV, collected by recoding and taking a note. Data validation investigated by applying data triangulation. Then, data analyzed by using interactive models. The result study presented that (1 humor discourse of impicature entity on Ini Talkshow such as mentioning, expressing, refusing, instituating, judging, accusing, claiming, asking/want, mocking, evicting, and threatening; (2 violated of cooperative principle maxim such as quantity, quality, relevance, and manner; and (3 besides violating cooperative principle, the implicature expressing also violated positive and negative politeness. This violation was done deliberately in case to create the humor sense of audience minds.

  3. An energy balance perspective on regional CO2-induced temperature changes in CMIP5 models

    OpenAIRE

    Räisänen, Jouni

    2017-01-01

    An energy balance decomposition of temperature changes is conducted for idealized transient CO2-only simulations in the fifth phase of the Coupled Model Intercomparison Project. The multimodel global mean warming is dominated by enhanced clear-sky greenhouse effect due to increased CO2 and water vapour, but other components of the energy balance substantially modify the geographical and seasonal patterns of the change. Changes in the net surface energy flux are important over the oceans, bein...

  4. SOCIAL NET: A CASE STUDY OF THE UNIVERSITY NET OF POPULAR COOPERATIVES TECHNOLOGICAL INCUBATORS (PCTIS NET FROM THE INTERACTION AMONG THE INCUBATORS

    Directory of Open Access Journals (Sweden)

    Marília Matos Pereira Lopes

    2014-07-01

    Full Text Available The objective of this assignment was to identify if the University Net of Popular Cooperatives Technological Incubators (PCTIs Net is a social net. The research was an exploratory nature study with descriptive character, the technical procedure of the present research was the case study. The questionnaire was applied in 82% of the incubators belonging to the PCTIs Net, and interviews. The information acquired through the questionnaire was gathered and tabulated to compose the characterization of the net incubators and the social analyzer. With the Pajek program was created the social analyzer and the centralizing box. Was performed to compare the results with previous work Rennó et al. (2010 proposed that the same goal using a different approach. Ending the analysis guided by the characteristics of a social net, it was observed that the PCTIs Net is a social net, however it was emphasized that the existing communication is a point where the net needs to be fortified.

  5. The net charge at interfaces between insulators

    Science.gov (United States)

    Bristowe, N. C.; Littlewood, P. B.; Artacho, Emilio

    2011-03-01

    The issue of the net charge at insulating oxide interfaces is briefly reviewed with the ambition of dispelling myths of such charges being affected by covalency and related charge density effects. For electrostatic analysis purposes, the net charge at such interfaces is defined by the counting of discrete electrons and core ion charges, and by the definition of the reference polarization of the separate, unperturbed bulk materials. The arguments are illustrated for the case of a thin film of LaAlO3 over SrTiO3 in the absence of free carriers, for which the net charge is exactly 0.5e per interface formula unit, if the polarization response in both materials is referred to zero bulk values. Further consequences of the argument are extracted for structural and chemical alterations of such interfaces, in which internal rearrangements are distinguished from extrinsic alterations (changes of stoichiometry, redox processes), only the latter affecting the interfacial net charge. The arguments are reviewed alongside the proposal of Stengel and Vanderbilt (2009 Phys. Rev. B 80 241103) of using formal polarization values instead of net interfacial charges, based on the interface theorem of Vanderbilt and King-Smith (1993 Phys. Rev. B 48 4442-55). Implications for non-centrosymmetric materials are discussed, as well as for interfaces for which the charge mismatch is an integer number of polarization quanta.

  6. Automating Ontological Annotation with WordNet

    Energy Technology Data Exchange (ETDEWEB)

    Sanfilippo, Antonio P.; Tratz, Stephen C.; Gregory, Michelle L.; Chappell, Alan R.; Whitney, Paul D.; Posse, Christian; Paulson, Patrick R.; Baddeley, Bob L.; Hohimer, Ryan E.; White, Amanda M.

    2006-01-22

    Semantic Web applications require robust and accurate annotation tools that are capable of automating the assignment of ontological classes to words in naturally occurring text (ontological annotation). Most current ontologies do not include rich lexical databases and are therefore not easily integrated with word sense disambiguation algorithms that are needed to automate ontological annotation. WordNet provides a potentially ideal solution to this problem as it offers a highly structured lexical conceptual representation that has been extensively used to develop word sense disambiguation algorithms. However, WordNet has not been designed as an ontology, and while it can be easily turned into one, the result of doing this would present users with serious practical limitations due to the great number of concepts (synonym sets) it contains. Moreover, mapping WordNet to an existing ontology may be difficult and requires substantial labor. We propose to overcome these limitations by developing an analytical platform that (1) provides a WordNet-based ontology offering a manageable and yet comprehensive set of concept classes, (2) leverages the lexical richness of WordNet to give an extensive characterization of concept class in terms of lexical instances, and (3) integrates a class recognition algorithm that automates the assignment of concept classes to words in naturally occurring text. The ensuing framework makes available an ontological annotation platform that can be effectively integrated with intelligence analysis systems to facilitate evidence marshaling and sustain the creation and validation of inference models.

  7. Ontological Annotation with WordNet

    Energy Technology Data Exchange (ETDEWEB)

    Sanfilippo, Antonio P.; Tratz, Stephen C.; Gregory, Michelle L.; Chappell, Alan R.; Whitney, Paul D.; Posse, Christian; Paulson, Patrick R.; Baddeley, Bob; Hohimer, Ryan E.; White, Amanda M.

    2006-06-06

    Semantic Web applications require robust and accurate annotation tools that are capable of automating the assignment of ontological classes to words in naturally occurring text (ontological annotation). Most current ontologies do not include rich lexical databases and are therefore not easily integrated with word sense disambiguation algorithms that are needed to automate ontological annotation. WordNet provides a potentially ideal solution to this problem as it offers a highly structured lexical conceptual representation that has been extensively used to develop word sense disambiguation algorithms. However, WordNet has not been designed as an ontology, and while it can be easily turned into one, the result of doing this would present users with serious practical limitations due to the great number of concepts (synonym sets) it contains. Moreover, mapping WordNet to an existing ontology may be difficult and requires substantial labor. We propose to overcome these limitations by developing an analytical platform that (1) provides a WordNet-based ontology offering a manageable and yet comprehensive set of concept classes, (2) leverages the lexical richness of WordNet to give an extensive characterization of concept class in terms of lexical instances, and (3) integrates a class recognition algorithm that automates the assignment of concept classes to words in naturally occurring text. The ensuing framework makes available an ontological annotation platform that can be effectively integrated with intelligence analysis systems to facilitate evidence marshaling and sustain the creation and validation of inference models.

  8. Development of net cage acoustic alarm system

    Science.gov (United States)

    Hong, Shih-Wei; Wei, Ruey-Chang

    2004-05-01

    In recent years, the fishery production has been drastically decreased in Taiwan, mainly due to overfishing and coast pollution; therefore, fishermen and corporations are encouraged by government to invest in ocean net cage aquaculture. However, the high-price fishes in the net cage are often coveted, so incidences of fish stealing and net cage breaking were found occasionally, which cause great economical loss. Security guards or a visual monitoring system has limited effect, especially in the night when these intrusions occur. This study is based on acoustic measure to build a net cage alarm system, which includes the sonobuoy and monitor station on land. The sonobuoy is a passive sonar that collects the sounds near the net cage and transmits the suspected signal to the monitor station. The signals are analyzed by the control program on the personal computer in the monitor station, and the alarms at different stages could be activated by the sound levels and durations of the analyzed data. To insure long hours of surveillance, a solar panel is applied to charge the battery, and a photodetector is used to activate the system.

  9. The NeuroDevNet vision.

    Science.gov (United States)

    Goldowitz, Dan; McArthur, Dawn

    2011-03-01

    The NeuroDevNet Network of Centres of Excellence has created the first trans-Canada effort devoted to the study of brain development from basic to clinical to societal perspectives. NeuroDevNet's vision is to accelerate efforts to (i) understand normal brain development; (ii) enhance our ability to make diagnoses of when normal development goes awry; and (iii) develop interventions to improve or prevent neurodevelopmental disorders. An early diagnosis coupled with the right therapies, The NeuroDevNet Network of Centres of Excellence has created the first trans-Canada effort devoted to the study of brain development from basic to clinical to societal perspectives. NeuroDevNet's vision is to accelerate efforts to (i) understand normal brain development; (ii) enhance our ability to make diagnoses of when normal development goes awry; and (iii) develop interventions to improve or prevent neurodevelopmental disorders. An early diagnosis coupled with the right therapies, Demonstration Projects. Funds were also allocated for an Opportunities Initiative. There is a wide of expertise amongst NeuroDevNet members. Researchers are supported by the management centre, three Platforms (Imaging; Genetics/ Epigenetics; Animal Models) and three Cores (Neuroethics; Neuroinformatics; Knowledge Translation). We emphasize multidisciplinary training of young researchers to advance the understanding of brain disorders that affect children. Copyright © 2011 Elsevier Inc. All rights reserved.

  10. The net charge at interfaces between insulators

    Energy Technology Data Exchange (ETDEWEB)

    Bristowe, N C; Littlewood, P B [Theory of Condensed Matter Group, Cavendish Laboratory, University of Cambridge, J J Thomson Avenue, Cambridge CB3 0HE (United Kingdom); Artacho, Emilio, E-mail: ncb30@cam.ac.uk [Department of Earth Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EQ (United Kingdom)

    2011-03-02

    The issue of the net charge at insulating oxide interfaces is briefly reviewed with the ambition of dispelling myths of such charges being affected by covalency and related charge density effects. For electrostatic analysis purposes, the net charge at such interfaces is defined by the counting of discrete electrons and core ion charges, and by the definition of the reference polarization of the separate, unperturbed bulk materials. The arguments are illustrated for the case of a thin film of LaAlO{sub 3} over SrTiO{sub 3} in the absence of free carriers, for which the net charge is exactly 0.5e per interface formula unit, if the polarization response in both materials is referred to zero bulk values. Further consequences of the argument are extracted for structural and chemical alterations of such interfaces, in which internal rearrangements are distinguished from extrinsic alterations (changes of stoichiometry, redox processes), only the latter affecting the interfacial net charge. The arguments are reviewed alongside the proposal of Stengel and Vanderbilt (2009 Phys. Rev. B 80 241103) of using formal polarization values instead of net interfacial charges, based on the interface theorem of Vanderbilt and King-Smith (1993 Phys. Rev. B 48 4442-55). Implications for non-centrosymmetric materials are discussed, as well as for interfaces for which the charge mismatch is an integer number of polarization quanta. (viewpoint)

  11. Regular expressions cookbook

    CERN Document Server

    Goyvaerts, Jan

    2009-01-01

    This cookbook provides more than 100 recipes to help you crunch data and manipulate text with regular expressions. Every programmer can find uses for regular expressions, but their power doesn't come worry-free. Even seasoned users often suffer from poor performance, false positives, false negatives, or perplexing bugs. Regular Expressions Cookbook offers step-by-step instructions for some of the most common tasks involving this tool, with recipes for C#, Java, JavaScript, Perl, PHP, Python, Ruby, and VB.NET. With this book, you will: Understand the basics of regular expressions through a

  12. Regular Expression Pocket Reference

    CERN Document Server

    Stubblebine, Tony

    2007-01-01

    This handy little book offers programmers a complete overview of the syntax and semantics of regular expressions that are at the heart of every text-processing application. Ideal as a quick reference, Regular Expression Pocket Reference covers the regular expression APIs for Perl 5.8, Ruby (including some upcoming 1.9 features), Java, PHP, .NET and C#, Python, vi, JavaScript, and the PCRE regular expression libraries. This concise and easy-to-use reference puts a very powerful tool for manipulating text and data right at your fingertips. Composed of a mixture of symbols and text, regular exp

  13. Life Balancing -- A Better Way to Balance Large Batteries

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, R. Dyche; Zane, Regan; Plett, Gregory; Maksimovic, Dragan; Smith, Kandler; Trimboli, M. Scott

    2017-03-28

    A new cell balancing technology was developed under a Department of Energy contract which merges the DC/DC converter function into cell balancing. Instead of conventional passive cell balancing technology which bypasses current through a resistor, or active cell balancing which moves current from one cell to another, with significant cost and additional inefficiencies, this concept takes variable amount of current from each cell or small group of cells and converts it to current for the low voltage system.

  14. Balancing trust and power

    DEFF Research Database (Denmark)

    Broholm-Jørgensen, Marie; Guassora, Ann Dorrit; Reventlow, Susanne

    2017-01-01

    from the GPs' perspectives, and in what way trust and power affect and/or challenge strategies towards retaining patients without formal education. DESIGN: Data in this study were obtained through semi-structured interviews with GPs participating in an intervention project, as well as observations......OBJECTIVE: Little is known about how strategies of retaining patients are acted out by general practitioners (GPs) in the clinical encounter. With this study, we apply Grimens' (2009) analytical connection between trust and power to explore how trust and power appear in preventive health checks...... of power in the encounter. The GPs articulated that a balance was needed in preventive health checks in order to establish trust and thus retain the patient in the clinic. One way this balance of respect was carried out was with the use of humour. CONCLUSIONS: To retain patients without formal education...

  15. Ankylosing Spondylitis and Balance

    OpenAIRE

    Uckun, Alper; Sezer, Ilhan

    2017-01-01

    Ankylosing spondylitis is a chronic inflammatory disease that mainly affects axial joints and the changes in the vertebrae cause typical kyphotic posture. In patients with ankylosing spondylitis, the postural changes, including cervical flexion, decreased lumbar lordosis, posterior rotation of pelvis, hip extension, knee flexion, and plantar flexion of ankle along with kyphosis, may occur in the upcoming terms of the disease and may negatively affect balance. Joint and eye involvements; muscu...

  16. Explosive Target Balances

    OpenAIRE

    Potrafke, Niklas; Reischmann, Markus

    2013-01-01

    Using the new unit root test by Phillips et al. (2011) we show that the Target balances of the German Bundesbank have been exploding from the beginning of 2009 to the beginning of 2013. By implementing a full-allotment policy and reducing the required minimum quality of collaterals in October 2008, the European Central Bank (ECB) refinanced credits in the GIIPS countries to a large extent. Private capital flowed out of the GIIPS countries (Greece, Italy, Ireland, Portugal and Spain), and the ...

  17. Association mapping utilizing diverse barley lines reveals net form net blotch seedling resistance/susceptibility loci

    Science.gov (United States)

    Pyrenophora teres f. teres is a necrotrophic fungal pathogen and the causal agent of the economically important foliar disease net form net blotch (NFNB) of barley. The deployment of effective and durable resistance against P. teres f. teres has been hindered by the complexity of quantitative resist...

  18. Implementace metody Balanced Scorecard

    OpenAIRE

    Neuwirth, Pavel

    2014-01-01

    Diplomová práce je zaměřena na hodnocení výkonnosti společnosti pomocí metody Balanced Scorecard. Teoretická část práce popisuje východiska měření výkonnosti, metody Balanced Scorecard a postup při její implementaci. Analytická část vychází z teoretických poznatků z první části a hodnotí situaci společnosti finanční analýzou poměrových ukazatelů, strategickou analýzou a následným sestavením návrhu implementace metody Balanced Scorecard v konkrétní společnosti. Thesis is focused on evaluati...

  19. Towards Self-Managed Executable Petri Nets

    DEFF Research Database (Denmark)

    Hansen, Klaus Marius; Zhang, Weishan; Ingstrup, Mads

    2008-01-01

    An issue in self-managed systems is that different abstractions and programming models are used on different architectural layers, leading to systems that are harder to build and understand. To alleviate this, we introduce a self-management approach which combines high-level Petri nets...... with the capability of distributed communication among nets. Organized in a three-layer goal management, change management, and component control architecture this allows for self-management in distributed systems. We validate the approach through the Flamenco/CPN middleware that allows for self-management of service......-oriented pervasive computing systems through the runtime interpretation of colored Petri nets. The current work focuses on the change management and component control layers....

  20. Professional ASP.NET MVC 2

    CERN Document Server

    Galloway, Jon; Haack, Phil

    2010-01-01

    Top-selling MVC book from a top team at Microsoft—now fully updated!. ASP.NET MVC 2.0 is now available and shipping with Visual Studio 2010 and .NET 4. A new update to Microsoft's Model-View-Controller technologies, MVC 2.0 enables developers to build dynamic, data-driven Web sites. This in-depth book shows you step-by-step how to use MVC 2.0. You'll learn both the theory behind MVC 2.0, as well as walk through practical tutorials, where you'll create a real-world application. Topics include transitioning from ASP.NET development, as well as an overview of related tools and technologies, inclu

  1. .net core application lifecycle on Openshift

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    # .net core application lifecycle on Openshift I will show an example of a lifecycle of an OpenShift application with an emphasis on the continuous integration and deployment. The application compatible with [.net Standard](https://docs.microsoft.com/en-us/dotnet/standard/net-standard) can be easily deployed on OpenShift using [Source2Image](https://docs.openshift.com/enterprise/3.0/architecture/core_concepts/builds_and_image_streams.html#source-build) functionality, which doesn't require developers to maintain docker images of the application. I will also present how to efficiently integrate this feature into GitLab pipelines with an automated deployment of the "review" environment, as one its parts.

  2. Application and Theory of Petri Nets

    DEFF Research Database (Denmark)

    This volume contains the proceedings of the 13th International Conference onApplication and Theory of Petri Nets, held in Sheffield, England, in June 1992. The aim of the Petri net conferences is to create a forum for discussing progress in the application and theory of Petri nets. Typically......, the conferences have 150-200 participants, one third of these coming from industry and the rest from universities and research institutions. The 1992 conference was organized by the School of Computing and Management Sciences at Sheffield City Polytechnic, England. The volume contains twoinvited papers, by G....... Balbo and W. Reisig, 18 submitted papers, and seven project papers. The submitted papers and project presentations were selectedby the programme committee and a panel of referees from a large number of submissions....

  3. Chapter 17: Estimating Net Savings: Common Practices

    Energy Technology Data Exchange (ETDEWEB)

    Violette, D. M.; Rathbun, P.

    2014-09-01

    This chapter focuses on the methods used to estimate net energy savings in evaluation, measurement, and verification (EM&V) studies for energy efficiency (EE) programs. The chapter provides a definition of net savings, which remains an unsettled topic both within the EE evaluation community and across the broader public policy evaluation community, particularly in the context of attribution of savings to particular program. The chapter differs from the measure-specific Uniform Methods Project (UMP) chapters in both its approach and work product. Unlike other UMP resources that provide recommended protocols for determining gross energy savings, this chapter describes and compares the current industry practices for determining net energy savings, but does not prescribe particular methods.

  4. The transition from No Net Loss to a Net Gain of biodiversity is far from trivial

    DEFF Research Database (Denmark)

    Bull, Joseph William; Brownlie, S.

    2017-01-01

    The objectives of No Net Loss and Net Gain have emerged as key principles in conservation policy. Both give rise to mechanisms by which certain unavoidable biodiversity losses associated with development are quantified, and compensated with comparable gains (e.g. habitat restoration). The former...... seeks a neutral outcome for biodiversity after losses and gains are accounted for, and the latter seeks an improved outcome. Policy-makers often assume that the transition from one to the other is straightforward and essentially a question of the amount of compensation provided. Consequently, companies...... increasingly favour Net Gain type commitments, and financial institutions make lending conditional on either objective, depending on the habitat involved. We contend, however, that achieving Net Gain is fundamentally different to achieving No Net Loss, and moving from one to the other is less trivial than...

  5. Spolupráce mezi VB.NET a MS Office - metodická příručka

    OpenAIRE

    PROŠEK, Václav

    2013-01-01

    This dissertation deals with processes how to work with applications of office package by Microsoft Office from the ambience of NET Framework through the programming language Visual Basic.NET. These processes are used to develop the application for calibration of balance. The result of this application is a calibration sheet as a document of Microsoft Word text editor and a workbook of spreadsheet Microsoft Excel comparing calculations in the application with formulas of spreadsheet Excel.

  6. APIs de seguridad en .NET Framework

    OpenAIRE

    Domínguez Ruiz, Abel

    2014-01-01

    Este trabajo hace un estudio de algunas de las herramientas de seguridad disponibles en .Net Framework así como la forma de usarlas en un desarrollo web bajo la metodología de desarrollo de ASP.NET siguiendo el modelo Vista-Controlador y usando como entorno de desarrollo Visual Studio. Además de repasar las herramientas disponibles y la forma de uso se ha desarrollado también una aplicación de ejemplo: ItemCoteca-Web; en la que se demuestra cómo resolver el registro de usuarios, la autenticac...

  7. An ECNO semantics for Petri nets

    DEFF Research Database (Denmark)

    Kindler, Ekkart

    2012-01-01

    The Event Coordination Notation (ECNO) allows modelling the behaviour of software on top of structural software models - and to generate program code from these models fully automatically. ECNO distinguishes between the local behaviour of elements (objects) and the global behaviour, which denes t...... work. In this paper, we will show that the ECNO, in turn, can be used for modelling the behaviour of Petri nets in a simple and concise way. What is more, we will show that the ECNO semantics of Place/Transition Systems can easily be extended to so-called signal-event nets....

  8. Introducing NET 40 With Visual Studio 2010

    CERN Document Server

    Mackey, A

    2010-01-01

    Microsoft is introducing a large number of changes to the way that the .NET Framework operates. Familiar technologies are being altered, best practices replaced, and developer methodologies adjusted. Many developers find it hard to keep up with the pace of change across .NET's ever-widening array of technologies. You may know what's happening in C#, but how about the Azure cloud? How is that going to affect your work? What are the limitations of the new pLINQ syntax? What you need is a roadmap. A guide to help you see the innovations that matter and to give you a head start on the opportunitie

  9. Deep Belief Nets for Topic Modeling

    DEFF Research Database (Denmark)

    Maaløe, Lars; Arngren, Morten; Winther, Ole

    2015-01-01

    -formative. In this paper we describe large-scale content based collaborative filtering for digital publishing. To solve the digital publishing recommender problem we compare two approaches: latent Dirichlet allocation (LDA) and deep be-lief nets (DBN) that both find low-dimensional latent representations for documents....... Efficient retrieval can be carried out in the latent representation. We work both on public benchmarks and digital media content provided by Issuu, an on-line publishing platform. This article also comes with a newly developed deep belief nets toolbox for topic modeling tailored towards performance...

  10. Performance Analysis Using Coloured Petri Nets

    DEFF Research Database (Denmark)

    Wells, Lisa Marie

    2002-01-01

    This paper provides an overview of improved facilities for performance analysis using coloured Petri nets. Coloured Petri nets is a formal method that is well suited for modeling and analyzing large and complex systems. The paper describes steps that have been taken to make a distinction between...... modeling the behavior of a system and observing the behavior of a model. Performance-related facilities are discussed, including facilities for collecting data, running multiple simulations, generating statistically reliable simulation output, and comparing alternative system configurations....

  11. Net Gain: A New Method for Preventing Malaria Deaths | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    A finely spun net could prevent as many as one-third of all child deaths in Africa, reports IDRC's new publication, Net Gain. Studies conducted in Gambia, Ghana, and Kenya show that the insecticide-treated mosquito net reduced the mortality rate of children under 5 years of age by up to 63 percent. Net Gain reviews and ...

  12. Signal transducer and activator of transcription 3 (STAT3) and Suppressor of Cytokine Signaling (SOCS3) balance controls cytotoxicity and IL-10 expression in decidual-like natural killer cell line NK-92.

    Science.gov (United States)

    Braunschweig, Anne; Poehlmann, Tobias G; Busch, Susann; Schleussner, Ekkehard; Markert, Udo R

    2011-10-01

    OBJECTIVES  In previous studies, we have shown that sHLA-G reduces cytotoxicity of decidual NK cells, which was dependent upon reduction in signal transducer and activator of transcription 3 (STAT3) and perforin. In this study, we aimed to confirm the role of STAT3 for induction of cytotoxicity and to analyze the regulative role of its antagonist suppressor of cytokine signaling 3 (SOCS3). Furthermore, the influence of both factors on cytokine expression should be analyzed. METHODS  All experiments were performed on NK-92 cells. STAT3 and SOCS3 have been silenced using two different small interfering RNA sequences each. Silencing efficiency and STAT3 tyrosine phosphorylation have been analyzed by Western blotting. Cytotoxicity to K562 target cells has been assessed by flow cytometry. Expression of IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, TNF-α, and TNF-β has been measured using cytometric bead arrays for flow cytometry. RESULTS  STAT3 and SOCS3 have been successfully silenced. STAT3 silencing reduced cytotoxicity. SOCS3 silencing induced increase in STAT3 tyrosine phosphorylation and cytotoxicity. STAT3 silencing reduced IL-10 expression significantly, while SOCS3 silencing induced, also significantly, the opposite effect. The other cytokines were expressed at very low concentration or not constantly affected. CONCLUSION  STAT3 and SOCS3 are involved in regulation of NK cell cytotoxicity and IL-10 expression. © 2011 John Wiley & Sons A/S.

  13. Balanced skills among nascent entrepreneurs

    OpenAIRE

    Stuetzer, Michael; Obschonka, Martin; Schmitt-Rodermund, Eva

    2012-01-01

    This paper examines the effects and origins of balanced skills among nascent entrepreneurs. In a first step we apply Lazear’s jack-of-all-trades theory to investigate performance effects of a balanced skill set. Second, we investigate potential sources of balanced skills, thereby testing the investment hypothesis against the endowment hypothesis. Analyzing data on high-potential nascent projects, we find support for the notion that balanced skills are important for making progress in the vent...

  14. Coloured Petri Nets: Basic Concepts, Analysis Methods and Practical Use. Vol. 3, Practical Use

    DEFF Research Database (Denmark)

    Jensen, Kurt

    for operations that are used in many arc expressions. These modifications make the CP-nets more appropriate as study material, but they do not change the essential behaviour of the CPN models. The terminology in the original material has been modified to fit the terminology introduced in the first two volumes...

  15. Statistical inference for remote sensing-based estimates of net deforestation

    Science.gov (United States)

    Ronald E. McRoberts; Brian F. Walters

    2012-01-01

    Statistical inference requires expression of an estimate in probabilistic terms, usually in the form of a confidence interval. An approach to constructing confidence intervals for remote sensing-based estimates of net deforestation is illustrated. The approach is based on post-classification methods using two independent forest/non-forest classifications because...

  16. Nuclear Medicine in Patients with NET: Radiolabeled Somatostatin Analogues and their Brothers.

    Science.gov (United States)

    Cuccurullo, Vincenzo; Prisco, Maria R; Di Stasio, Giuseppe D; Mansi, Luigi

    2017-01-01

    Although Somastostatin (SS) scintigraphy (SRS) has been introduced many years ago, it remains the most diffuse radionuclide diagnostic tool in patients with neuroendocrine tumours (NETs). Being SS receptors (SSTR) expressed in the majority of NETs, radiolabeled SS analogues (SS-A) provide high diagnostic accuracy, mainly in patients with gastro-entero-pancreatic (GEP) tumors. SSTR are the best target for radiotracers used either for diagnostic and therapeutic purposes in NETs due to their presence on the surface of neoplastic cells of clinical interest. 111In- DTPA-octreotide (111In-Pentetreotide, Octreoscan®), may detect either primitive or secondary lesions in the presence of a satisfactory lesion/background ratio. The unsatisfactory diagnostic performance of 18F-Fluorodeoxyglucose (18F-FDG), in NETs stimulated the synthesis of more specific positron-emitting tracers and SS-A labeled with 68Gallium (DOTA-peptides) represent actually the best radionuclide procedure for NET imaging. Alternative radiotracers, labeled either with gamma or positron emitters and showing different uptake mechanisms, as 18F-DOPA (Fluorine- 18-L-dihydroxyphenylalanine), have also been proposed and clinically utilized. Octreoscan®, despite its limitations, continue to represent the most frequently used method in evaluating the response to treatment and in follow-up of patients with NET, although the better diagnostic accuracy of DOTA-peptides. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  17. Markets, voucher subsidies and free nets combine to achieve high bed net coverage in rural Tanzania

    Directory of Open Access Journals (Sweden)

    Gerrets Rene PM

    2008-06-01

    Full Text Available Abstract Background Tanzania has a well-developed network of commercial ITN retailers. In 2004, the government introduced a voucher subsidy for pregnant women and, in mid 2005, helped distribute free nets to under-fives in small number of districts, including Rufiji on the southern coast, during a child health campaign. Contributions of these multiple insecticide-treated net delivery strategies existing at the same time and place to coverage in a poor rural community were assessed. Methods Cross-sectional household survey in 6,331 members of randomly selected 1,752 households of 31 rural villages of Demographic Surveillance System in Rufiji district, Southern Tanzania was conducted in 2006. A questionnaire was administered to every consenting respondent about net use, treatment status and delivery mechanism. Findings Net use was 62.7% overall, 87.2% amongst infants (0 to1 year, 81.8% amongst young children (>1 to 5 years, 54.5% amongst older children (6 to 15 years and 59.6% amongst adults (>15 years. 30.2% of all nets had been treated six months prior to interview. The biggest source of nets used by infants was purchase from the private sector with a voucher subsidy (41.8%. Half of nets used by young children (50.0% and over a third of those used by older children (37.2% were obtained free of charge through the vaccination campaign. The largest source of nets amongst the population overall was commercial purchase (45.1% use and was the primary means for protecting adults (60.2% use. All delivery mechanisms, especially sale of nets at full market price, under-served the poorest but no difference in equity was observed between voucher-subsidized and freely distributed nets. Conclusion All three delivery strategies enabled a poor rural community to achieve net coverage high enough to yield both personal and community level protection for the entire population. Each of them reached their relevant target group and free nets only temporarily

  18. A carbon balance model for the great dismal swamp ecosystem.

    Science.gov (United States)

    Sleeter, Rachel; Sleeter, Benjamin M; Williams, Brianna; Hogan, Dianna; Hawbaker, Todd; Zhu, Zhiliang

    2017-12-01

    Carbon storage potential has become an important consideration for land management and planning in the United States. The ability to assess ecosystem carbon balance can help land managers understand the benefits and tradeoffs between different management strategies. This paper demonstrates an application of the Land Use and Carbon Scenario Simulator (LUCAS) model developed for local-scale land management at the Great Dismal Swamp National Wildlife Refuge. We estimate the net ecosystem carbon balance by considering past ecosystem disturbances resulting from storm damage, fire, and land management actions including hydrologic inundation, vegetation clearing, and replanting. We modeled the annual ecosystem carbon stock and flow rates for the 30-year historic time period of 1985-2015, using age-structured forest growth curves and known data for disturbance events and management activities. The 30-year total net ecosystem production was estimated to be a net sink of 0.97 Tg C. When a hurricane and six historic fire events were considered in the simulation, the Great Dismal Swamp became a net source of 0.89 Tg C. The cumulative above and below-ground carbon loss estimated from the South One and Lateral West fire events totaled 1.70 Tg C, while management activities removed an additional 0.01 Tg C. The carbon loss in below-ground biomass alone totaled 1.38 Tg C, with the balance (0.31 Tg C) coming from above-ground biomass and detritus. Natural disturbances substantially impact net ecosystem carbon balance in the Great Dismal Swamp. Through alternative management actions such as re-wetting, below-ground biomass loss may have been avoided, resulting in the added carbon storage capacity of 1.38 Tg. Based on two model assumptions used to simulate the peat system, (a burn scar totaling 70 cm in depth, and the soil carbon accumulation rate of 0.36 t C/ha -1 /year -1 for Atlantic white cedar), the total soil carbon loss from the South One and Lateral West fires

  19. A carbon balance model for the great dismal swamp ecosystem

    Directory of Open Access Journals (Sweden)

    Rachel Sleeter

    2017-01-01

    Full Text Available Abstract Background Carbon storage potential has become an important consideration for land management and planning in the United States. The ability to assess ecosystem carbon balance can help land managers understand the benefits and tradeoffs between different management strategies. This paper demonstrates an application of the Land Use and Carbon Scenario Simulator (LUCAS model developed for local-scale land management at the Great Dismal Swamp National Wildlife Refuge. We estimate the net ecosystem carbon balance by considering past ecosystem disturbances resulting from storm damage, fire, and land management actions including hydrologic inundation, vegetation clearing, and replanting. Results We modeled the annual ecosystem carbon stock and flow rates for the 30-year historic time period of 1985–2015, using age-structured forest growth curves and known data for disturbance events and management activities. The 30-year total net ecosystem production was estimated to be a net sink of 0.97 Tg C. When a hurricane and six historic fire events were considered in the simulation, the Great Dismal Swamp became a net source of 0.89 Tg C. The cumulative above and below-ground carbon loss estimated from the South One and Lateral West fire events totaled 1.70 Tg C, while management activities removed an additional 0.01 Tg C. The carbon loss in below-ground biomass alone totaled 1.38 Tg C, with the balance (0.31 Tg C coming from above-ground biomass and detritus. Conclusions Natural disturbances substantially impact net ecosystem carbon balance in the Great Dismal Swamp. Through alternative management actions such as re-wetting, below-ground biomass loss may have been avoided, resulting in the added carbon storage capacity of 1.38 Tg. Based on two model assumptions used to simulate the peat system, (a burn scar totaling 70 cm in depth, and the soil carbon accumulation rate of 0.36 t C/ha−1/year−1 for Atlantic white cedar, the total

  20. A carbon balance model for the great dismal swamp ecosystem

    Science.gov (United States)

    Sleeter, Rachel; Sleeter, Benjamin M.; Williams, Brianna; Hogan, Dianna; Hawbaker, Todd J.; Zhu, Zhiliang

    2017-01-01

    BackgroundCarbon storage potential has become an important consideration for land management and planning in the United States. The ability to assess ecosystem carbon balance can help land managers understand the benefits and tradeoffs between different management strategies. This paper demonstrates an application of the Land Use and Carbon Scenario Simulator (LUCAS) model developed for local-scale land management at the Great Dismal Swamp National Wildlife Refuge. We estimate the net ecosystem carbon balance by considering past ecosystem disturbances resulting from storm damage, fire, and land management actions including hydrologic inundation, vegetation clearing, and replanting.ResultsWe modeled the annual ecosystem carbon stock and flow rates for the 30-year historic time period of 1985–2015, using age-structured forest growth curves and known data for disturbance events and management activities. The 30-year total net ecosystem production was estimated to be a net sink of 0.97 Tg C. When a hurricane and six historic fire events were considered in the simulation, the Great Dismal Swamp became a net source of 0.89 Tg C. The cumulative above and below-ground carbon loss estimated from the South One and Lateral West fire events totaled 1.70 Tg C, while management activities removed an additional 0.01 Tg C. The carbon loss in below-ground biomass alone totaled 1.38 Tg C, with the balance (0.31 Tg C) coming from above-ground biomass and detritus.ConclusionsNatural disturbances substantially impact net ecosystem carbon balance in the Great Dismal Swamp. Through alternative management actions such as re-wetting, below-ground biomass loss may have been avoided, resulting in the added carbon storage capacity of 1.38 Tg. Based on two model assumptions used to simulate the peat system, (a burn scar totaling 70 cm in depth, and the soil carbon accumulation rate of 0.36 t C/ha−1/year−1 for Atlantic white cedar), the total soil carbon loss from the

  1. EVo: Net Shape RTM Production Line

    OpenAIRE

    Sven Torstrick; Felix Kruse; Martin Wiedemann

    2016-01-01

    EVo research platform is operated by the Center for Lightweight-Production-Technology of the German Aerospace Center in Stade. Its objective is technology demonstration of a fully automated RTM (Resin Transfer Molding) production line for composite parts in large quantities. Process steps include cutting and ply handling, draping, stacking, hot-forming, preform-trimming to net shape, resin injection, curing and demolding.

  2. The Lotto and Expected Net Revenue

    OpenAIRE

    Scoggins, John F.

    1995-01-01

    A multiperiod model (based on sales from the Florida Lotto) is used to estimate revenue and probability that the grand prize will roll over. Results indicate that allocating a greater percentage of ticket sales to the grand prize increases net revenue.

  3. Integrating phenotype ontologies with PhenomeNET

    KAUST Repository

    Rodriguez-Garcia, Miguel Angel

    2017-12-19

    Background Integration and analysis of phenotype data from humans and model organisms is a key challenge in building our understanding of normal biology and pathophysiology. However, the range of phenotypes and anatomical details being captured in clinical and model organism databases presents complex problems when attempting to match classes across species and across phenotypes as diverse as behaviour and neoplasia. We have previously developed PhenomeNET, a system for disease gene prioritization that includes as one of its components an ontology designed to integrate phenotype ontologies. While not applicable to matching arbitrary ontologies, PhenomeNET can be used to identify related phenotypes in different species, including human, mouse, zebrafish, nematode worm, fruit fly, and yeast. Results Here, we apply the PhenomeNET to identify related classes from two phenotype and two disease ontologies using automated reasoning. We demonstrate that we can identify a large number of mappings, some of which require automated reasoning and cannot easily be identified through lexical approaches alone. Combining automated reasoning with lexical matching further improves results in aligning ontologies. Conclusions PhenomeNET can be used to align and integrate phenotype ontologies. The results can be utilized for biomedical analyses in which phenomena observed in model organisms are used to identify causative genes and mutations underlying human disease.

  4. Soundness of Timed-Arc Workflow Nets

    DEFF Research Database (Denmark)

    Mateo, Jose Antonio; Srba, Jiri; Sørensen, Mathias Grund

    2014-01-01

    Analysis of workflow processes with quantitative aspects like timing is of interest in numerous time-critical applications. We suggest a workflow model based on timed-arc Petri nets and study the foundational problems of soundness and strong (time-bounded) soundness. We explore the decidability o...

  5. Dahl: Time ripe for DHS net assessment

    OpenAIRE

    2016-01-01

    Article review Center for Homeland Defense and Security instructor Erik Dahl urges the Department of Homeland Security to follow a practice of its military counterparts and establish an Office of Net Assessment that would gauge future threats and the nation's ability to mitigate them.

  6. Regular Event Structures and Finite Petri Nets

    DEFF Research Database (Denmark)

    Nielsen, M.; Thiagarajan, P.S.

    2002-01-01

    We present the notion of regular event structures and conjecture that they correspond exactly to finite 1-safe Petri nets. We show that the conjecture holds for the conflict-free case. Even in this restricted setting, the proof is non-trivial and involves a natural subclass of regular event...

  7. Net escapement of Antartic krill in trawls

    DEFF Research Database (Denmark)

    Krafft, B.A.; Krag, Ludvig Ahm; Herrmann, Bent

    This document describes the aims and methodology of a three year project (commenced in 2012) entitled Net Escapement of Antarctic krill in Trawls (NEAT). The study will include a morphology based mathematical modeling (FISHSELECT) of different sex and maturity groups of Antarctic krill (Euphausia...

  8. BioNet Digital Communications Framework

    Science.gov (United States)

    Gifford, Kevin; Kuzminsky, Sebastian; Williams, Shea

    2010-01-01

    BioNet v2 is a peer-to-peer middleware that enables digital communication devices to talk to each other. It provides a software development framework, standardized application, network-transparent device integration services, a flexible messaging model, and network communications for distributed applications. BioNet is an implementation of the Constellation Program Command, Control, Communications and Information (C3I) Interoperability specification, given in CxP 70022-01. The system architecture provides the necessary infrastructure for the integration of heterogeneous wired and wireless sensing and control devices into a unified data system with a standardized application interface, providing plug-and-play operation for hardware and software systems. BioNet v2 features a naming schema for mobility and coarse-grained localization information, data normalization within a network-transparent device driver framework, enabling of network communications to non-IP devices, and fine-grained application control of data subscription band width usage. BioNet directly integrates Disruption Tolerant Networking (DTN) as a communications technology, enabling networked communications with assets that are only intermittently connected including orbiting relay satellites and planetary rover vehicles.

  9. Programming C# Building NET Applications with C#

    CERN Document Server

    Liberty, Jesse

    2009-01-01

    Programming C#, the top-selling book on Microsoft's high-performance C# programming language, is now in its fourth edition. Aimed at experienced programmers and web developers, this comprehensive guide focuses on the features and programming patterns that are unique to C#, and fundamental to the programming of web services and web applications on Microsoft's .NET platform.

  10. NetBench. Automated Network Performance Testing

    CERN Document Server

    Cadeddu, Mattia

    2016-01-01

    In order to evaluate the operation of high performance routers, CERN has developed the NetBench software to run benchmarking tests by injecting various traffic patterns and observing the network devices behaviour in real-time. The tool features a modular design with a Python based console used to inject traffic and collect the results in a database, and a web user

  11. OK-Net Arable online knowledge platform

    DEFF Research Database (Denmark)

    Rasmussen, Ilse Ankjær; Jensen, Allan Leck; Jørgensen, Margit Styrbæk

    2017-01-01

    The complexity of organic farming requires farmers to have a very high level of knowledge and skills, but exchange on organic farming techniques remains limited. In order to increase productivity and quality in organic arable cropping in Europe, the thematic network OK-Net Arable under Horizon 20...

  12. Musings on Sketches, Artists, and Mosquito Nets

    Centers for Disease Control (CDC) Podcasts

    2014-09-23

    Byron Breedlove reads his essay Musings on Sketches, Artists, and Mosquito Nets about the art of James Whistler and the transmission of vector borne diseases.  Created: 9/23/2014 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 10/20/2014.

  13. Educating College Students of the Net Generation

    Science.gov (United States)

    Worley, Karen

    2011-01-01

    Faculty and administrators of higher education today face a challenge with their student populations, many of whom are part of what is known as the net generation. As students become more technologically advanced, faculty must be technologically ready to meet the needs of students. Many college faculty and administrators are from earlier…

  14. State Space Methods for Timed Petri Nets

    DEFF Research Database (Denmark)

    Christensen, Søren; Jensen, Kurt; Mailund, Thomas

    2001-01-01

    We present two recently developed state space methods for timed Petri nets. The two methods reconciles state space methods and time concepts based on the introduction of a global clock and associating time stamps to tokens. The first method is based on an equivalence relation on states which makes...

  15. Average Costs versus Net Present Value

    NARCIS (Netherlands)

    E.A. van der Laan (Erwin); R.H. Teunter (Ruud)

    2000-01-01

    textabstractWhile the net present value (NPV) approach is widely accepted as the right framework for studying production and inventory control systems, average cost (AC) models are more widely used. For the well known EOQ model it can be verified that (under certain conditions) the AC approach gives

  16. LINE BALANCING IN SERVICES

    Directory of Open Access Journals (Sweden)

    Hadi GÖKÇEN

    2002-01-01

    Full Text Available This paper investigates how the Assembly Line Balancing (ALB methods known for the production systems can be applied in service systems. For this purpose, an application study is done in a Physical therapy and rehabilitation clinic. Each standart service provided to patients is taken into consideration as a product, and problem is solved as a mixed model ALB problem. In conclusion, it is seen that the ALB methods developed for the production systems are also applicable in service systems. So, it is possible to do similar studies at hospitals, tax offices, driving licence and passport offices, fast food restaurants, etc.

  17. Balancing beyond the horizon?

    DEFF Research Database (Denmark)

    Kluth, Michael Friederich; Pilegaard, Jess

    2011-01-01

    The present article seeks to make sense of recent European Union (EU) naval capability changes by applying neo-realist theory to the EU as a collective actor in the global balance of power. The paper compares two different strands of neorealist theory by deducing key predictions about the expected...... naval posture of the Union and the corresponding expected changes in capabilities. These predictions are subsequently held up against post-cold war data on naval acquisitions in the EU. The paper concludes that the observed patterns are best explained not as bandwagoning with the USA, but as a long...

  18. Energy balance in JET

    Directory of Open Access Journals (Sweden)

    G.F. Matthews

    2017-08-01

    Full Text Available In this paper we discuss results from the study of the energy balance in JET based on calculated heating energies, radiated energy from bolometry and tile calorimetry. Recent data enables us to be more confident in the numbers used and to exclude certain possibilities but the overall energy imbalance which typically amounts to 25% of total input remains unexplained. This shows that caution is required in interpreting fractional radiated powers which are commonly used to measure the effectiveness of impurity seeded scenarios at reducing divertor heat load.

  19. A balanced transcription between telomerase and the telomeric DNA-binding proteins TRF1, TRF2 and Pot1 in resting, activated, HTLV-1-transformed and Tax-expressing human T lymphocytes

    Directory of Open Access Journals (Sweden)

    Gilson Eric

    2005-12-01

    Full Text Available Abstract Background The functional state of human telomeres is controlled by telomerase and by a protein complex named shelterin, including the telomeric DNA-binding proteins TRF1, TRF2 and Pot1 involved in telomere capping functions. The expression of hTERT, encoding the catalytic subunit of telomerase, plays a crucial role in the control of lymphocyte proliferation by maintaining telomere homeostasis. It has been previously found that hTERT activity is down-regulated by the human T cell leukaemia virus type 1 (HTLV-1 Tax protein in HTLV-1 transformed T lymphocytes. In this study, we have examined the effects of Tax expression on the transcriptional profile of telomerase and of shelterin in human T lymphocytes. Results We first provide evidence that the up-regulation of hTERT transcription in activated CD4+ T lymphocytes is associated with a down-regulation of that of TERF1, TERF2 and POT1 genes. Next, the down-regulation of hTERT transcription by Tax in HTLV-1 transformed or in Tax-expressing T lymphocytes is found to correlate with a significant increase of TRF2 and/or Pot1 mRNAs. Finally, ectopic expression of hTERT in one HTLV-1 T cell line induces a marked decrease in the transcription of the POT1 gene. Collectively, these observations predict that the increased transcriptional expression of shelterin genes is minimizing the impact on telomere instability induced by the down-regulation of hTERT by Tax. Conclusion These findings support the notion that Tax, telomerase and shelterin play a critical role in the proliferation of HTLV-1 transformed T lymphocytes.

  20. Effect of synthetic surfaces and vegetation in urban areas on human energy balance and comfort

    Science.gov (United States)

    Thomas F. Stark; David R. Miller

    1977-01-01

    The thermal balance of a standard man was quantified for a variety of urban and rural summer daytime microclimates. The resulting net heat-load data were correlated with the relative amounts of vegetation and synthetic materials at each site. By extrapolating these results, it is possible to estimate the expected heat load of a proposed development before it is built...

  1. The energy balance experiment EBEX-2000. Part III: Behaviour and quality of the radiation measurements

    NARCIS (Netherlands)

    Kohsiek, W.; Liebethal, C.; Foken, T.; Vogt, R.; Oncley, S.P.; Bernhofer, C.; Debruin, H.A.R.

    2007-01-01

    An important part of the Energy Balance Experiment (EBEX-2000) was the measurement of the net radiation and its components. Since the terrain, an irrigated cotton field, could not be considered homogeneous, radiation measurements were made at nine sites using a variety of radiation instruments,

  2. Cortical activation during balancing on a balance board.

    Science.gov (United States)

    Herold, Fabian; Orlowski, Katja; Börmel, Sabrina; Müller, Notger G

    2017-01-01

    Keeping one's balance is a complex motor task which requires the integration and processing of different sensory information. For this, higher cortical processes are essential. However, in the past research dedicated to the brain's involvement in balance control has predominantly used virtual reality paradigms whilst little is known about cortical activation during the challenging balancing on unstable surfaces (e.g. balance board). Hence, the main goal of this study was the simultaneous evaluation of cortical activation patterns and sway parameters during balancing on a balance board. Ten healthy adults were instructed to balance on a balance board while brain activation in supplementary motor area (SMA), precentral gyrus (PrG) and postcentral gyrus (PoG) was measured with functional near-infrared spectroscopy (fNIRS). Additionally, sway parameters were simultaneously recorded with one inertial sensor. Enhanced activation of SMA, PrG and PoG was observed when balancing was compared with still standing. Furthermore, the sway of pelvis (indicated by root mean square) increased in medio-lateral (ML) and anterior-posterior (AP) direction during the balance condition. Notably, a strong negative correlation was found between SMA activation and sway in ML direction during balancing, which was not observed during standing. Our results underline the important role of sensorimotor cortical areas for balance control. Moreover, the observed correlations suggest a crucial involvement of SMA in online control of sway in ML direction. Further research is needed to understand the contribution of other cortical and subcortcial areas to online balance control. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. Negative leave balances

    CERN Multimedia

    Human Resources Department

    2005-01-01

    Members of the personnel entitled to annual leave and, where appropriate, saved leave and/or compensatory leave are requested to take note of the new arrangements described below, which were recommended by the Standing Concertation Committee (SCC) at its meeting on 1Â September 2005 and subsequently approved by the Director-General. The changes do not apply to members of the personnel participating in the Progressive Retirement Programme (PRP) or the Part-time Work as a pre-retirement measure, for whom the specific provisions communicated at the time of joining will continue to apply. Â Negative balances in annual leave, saved leave and/or compensatory leave accounts at the end of the leave year (30th September) and on the date on which bonuses are credited to the saved leave account (31st December): Where members of the personnel have a leave account with a negative balance on 30Â September and/or 31Â December, leave will automatically be transferred from one account to another on the relevant dates i...

  4. Negative leave balances

    CERN Multimedia

    Human Resources Department

    2005-01-01

    Members of the personnel entitled to annual leave and, where appropriate, saved leave and/or compensatory leave are requested to take note of the new arrangements described below, which were recommended by the Standing Concertation Committee (SCC) at its meeting on 1 September 2005 and subsequently approved by the Director-General. The changes do not apply to members of the personnel participating in the Progressive Retirement Programme (PRP) or the Part-time Work as a pre-retirement measure, for whom the specific provisions communicated at the time of joining will continue to apply.  Negative balances in annual leave, saved leave and/or compensatory leave accounts at the end of the leave year (30th September) and on the date on which bonuses are credited to the saved leave account (31st December): Where members of the personnel have a leave account with a negative balance on 30 September and/or 31 December, leave will automatically be transferred from one account to another on the relevant dates in or...

  5. Balance ability and athletic performance.

    Science.gov (United States)

    Hrysomallis, Con

    2011-03-01

    The relationship between balance ability and sport injury risk has been established in many cases, but the relationship between balance ability and athletic performance is less clear. This review compares the balance ability of athletes from different sports, determines if there is a difference in balance ability of athletes at different levels of competition within the same sport, determines the relationship of balance ability with performance measures and examines the influence of balance training on sport performance or motor skills. Based on the available data from cross-sectional studies, gymnasts tended to have the best balance ability, followed by soccer players, swimmers, active control subjects and then basketball players. Surprisingly, no studies were found that compared the balance ability of rifle shooters with other athletes. There were some sports, such as rifle shooting, soccer and golf, where elite athletes were found to have superior balance ability compared with their less proficient counterparts, but this was not found to be the case for alpine skiing, surfing and judo. Balance ability was shown to be significantly related to rifle shooting accuracy, archery shooting accuracy, ice hockey maximum skating speed and simulated luge start speed, but not for baseball pitching accuracy or snowboarding ranking points. Prospective studies have shown that the addition of a balance training component to the activities of recreationally active subjects or physical education students has resulted in improvements in vertical jump, agility, shuttle run and downhill slalom skiing. A proposed mechanism for the enhancement in motor skills from balance training is an increase in the rate of force development. There are limited data on the influence of balance training on motor skills of elite athletes. When the effectiveness of balance training was compared with resistance training, it was found that resistance training produced superior performance results for

  6. Annual carbon balance of a peatland 10 yr following restoration

    Directory of Open Access Journals (Sweden)

    M. Strack

    2013-05-01

    Full Text Available Undisturbed peatlands represent long-term net sinks of carbon; however, peat extraction converts these systems into large and persistent sources of greenhouse gases. Although rewetting and restoration following peat extraction have taken place over the last several decades, very few studies have investigated the longer term impact of this restoration on peatland carbon balance. We determined the annual carbon balance of a former horticulturally-extracted peatland restored 10 yr prior to the study and compared these values to the carbon balance measured at neighboring unrestored and natural sites. Carbon dioxide (CO2 and methane (CH4 fluxes were measured using the chamber technique biweekly during the growing season from May to October 2010 and three times over the winter period. Dissolved organic carbon (DOC export was measured from remnant ditches in the unrestored and restored sites. During the growing season the restored site had greater uptake of CO2 than the natural site when photon flux density was greater than 1000 μmol m−2 s−1, while the unrestored site remained a source of CO2. Ecosystem respiration was similar between natural and restored sites, which were both significantly lower than the unrestored site. Methane flux remained low at the restored site except from open water pools, created as part of restoration, and remnant ditches. Export of DOC during the growing season was 5.0 and 28.8 g m−2 from the restored and unrestored sites, respectively. Due to dry conditions during the study year all sites acted as net carbon sources with annual balance of the natural, restored and unrestored sites of 250.7, 148.0 and 546.6 g C m−2, respectively. Although hydrological conditions and vegetation community at the restored site remained intermediate between natural and unrestored conditions, peatland restoration resulted in a large reduction in annual carbon loss from the system resulting in a carbon balance more similar to a natural

  7. Assessment of Global Annual Atmospheric Energy Balance from Satellite Observations

    Science.gov (United States)

    Lin, Bing; Stackhouse, Paul; Minnis, Patrick; Wielicki, Bruce A.; Hu, Yongxiang; Sun, Wenbo; Fan, Tai-Fang (Alice); Hinkelman, Laura

    2008-01-01

    Global atmospheric energy balance is one of the fundamental processes for the earth's climate system. This study uses currently available satellite data sets of radiative energy at the top of atmosphere (TOA) and surface and latent and sensible heat over oceans for the year 2000 to assess the global annual energy budget. Over land, surface radiation data are used to constrain assimilated results and to force the radiation, turbulent heat, and heat storage into balance due to a lack of observation-based turbulent heat flux estimations. Global annual means of the TOA net radiation obtained from both direct measurements and calculations are close to zero. The net radiative energy fluxes into the surface and the surface latent heat transported into the atmosphere are about 113 and 86 Watts per square meter, respectively. The estimated atmospheric and surface heat imbalances are about -8 9 Watts per square meter, values that are within the uncertainties of surface radiation and sea surface turbulent flux estimates and likely systematic biases in the analyzed observations. The potential significant additional absorption of solar radiation within the atmosphere suggested by previous studies does not appear to be required to balance the energy budget the spurious heat imbalances in the current data are much smaller (about half) than those obtained previously and debated at about a decade ago. Progress in surface radiation and oceanic turbulent heat flux estimations from satellite measurements significantly reduces the bias errors in the observed global energy budgets of the climate system.

  8. Reliability of the Wii Balance Board in kayak.

    Science.gov (United States)

    Vando, Stefano; Laffaye, Guillaume; Masala, Daniele; Falese, Lavinia; Padulo, Johnny

    2015-01-01

    the seat of the kayaker represent the principal contact point to express mechanical Energy. therefore we investigated the reliability of the Wii Balance Board measures in the kayak vs. on the ground. Bland-Altman test showed a low systematic bias on the ground (2.85%) and in kayak (-2.13%) respectively; while 0.996 for Intra-class correlation coefficient. the Wii Balance Board is useful to assess postural sway in kayak.

  9. Introducing idioms in the Galician WordNet: methods, problems and results

    OpenAIRE

    Álvarez de la Granja, María; Gómez Clemente, Xosé María; Gómez Guinovart, Xavier

    2016-01-01

    This study describes the introduction of verbal idioms in the Galician language version (Galnet) of the semantic network WordNet; a network that does not traditionally include many phraseological units. To enhance Galnet, a list of 803 Galician verbal idioms was developed to then review each of them individually and assess whether they could be introduced in an existing WordNet synset (a group of synonyms expressing the same concept) or not. Of those 803 idioms, 490 (61%) could be included in...

  10. Distinguishing Environment and System in Coloured Petri Net Models of Reactive Systems

    DEFF Research Database (Denmark)

    Tjell, Simon

    2007-01-01

    code-generation from models. A prototypical tool has been implemented for performing the structural analysis of Coloured Petri Net models and the principles of this tool is described. The aim of the paper is to make the guidelines and their formalized definitions along with a proof......This paper introduces and formally defines the environment-and-system-partitioned property for behavioral models of reactive systems expressed in the formal modeling language Coloured Petri Net. The purpose of the formalization is to make it possible to automatically validate any CPN model...

  11. Modeling safety requirements of an FMS using Petri-nets

    Science.gov (United States)

    Hanna, Moheb M.; Buck, A. A.; Smith, R.

    1993-08-01

    This paper is concerned with the modelling of safety requirements using Petri nets as a tool to model and simulate a Flexible Manufacturing System (FMS). The FMS cell described comprises a pick and place robot, a multi-head drilling machine together with a vision system and illustrates how the hierarchical structure of Petri nets can be used to ensure that all fail- safe requirements are satisfied; block diagrams together with fully detailed example Petri nets are given. The work demonstrates the use of cell and robot control Petro nets together with robot subnets for the x, y and z axes and associated output nets; the control and output nets are linked together with a safety net. Individual machines are linked with the control and safety nets of an FMS at cell level. The paper also illustrates how a Petri net can act as a decision maker during image inspection and identifies the unsafe conditions that can arise within an FMS.

  12. A new variant of Petri net controlled grammars

    Science.gov (United States)

    Jan, Nurhidaya Mohamad; Turaev, Sherzod; Fong, Wan Heng; Sarmin, Nor Haniza

    2015-10-01

    A Petri net controlled grammar is a Petri net with respect to a context-free grammar where the successful derivations of the grammar can be simulated using the occurrence sequences of the net. In this paper, we introduce a new variant of Petri net controlled grammars, called a place-labeled Petri net controlled grammar, which is a context-free grammar equipped with a Petri net and a function which maps places of the net to productions of the grammar. The language consists of all terminal strings that can be obtained by parallelly applying multisets of the rules which are the images of the sets of the input places of transitions in a successful occurrence sequence of the Petri net. We study the effect of the different labeling strategies to the computational power and establish lower and upper bounds for the generative capacity of place-labeled Petri net controlled grammars.

  13. One-step electro-spinning/netting technique for controllably preparing polyurethane nano-fiber/net.

    Science.gov (United States)

    Hu, Juanping; Wang, Xianfeng; Ding, Bin; Lin, Jinyou; Yu, Jianyong; Sun, Gang

    2011-11-01

    Electro-spinning/netting (ESN) as a cutting-edge technique evokes much interest because of its ability in the one-step preparation of versatile nano-fiber/net (NFN) membranes. Here, a controllable fabrication of polyurethane (PU) NFN membranes with attractive structures, consisting of common electrospun nanofibers and two-dimensional (2D) soap bubble-like structured nano-nets via an ESN process is reported. The unique nanoscaled NFN architecture can be finely controlled by regulating the solution properties and several ESN process parameters. The versatile PU nano-nets comprising interlinked nanowires with ultrathin diameters (5-40 nm) mean that the NFN structured membranes possess several excellent characteristics, such as an extremely large specific surface area, high porosity and large stacking density, which would be particularly useful for applications in ultrafiltration, special protective clothing, ultrasensitive sensors, catalyst support and so on. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Energy Dependence of Moments of Net-Proton, Net-Kaon, and Net-Charge Multiplicity Distributions at STAR

    CERN Document Server

    ,

    2016-01-01

    One of the main goals of the RHIC Beam Energy Scan (BES) program is to study the QCD phase structure, which includes the search for the QCD critical point, over a wide range of chemical potential. Theoretical calculations predict that fluctuations of conserved quantities, such as baryon number (B), charge (Q), and strangeness (S), are sensitive to the correlation length of the dynamical system. Experimentally, higher moments of multiplicity distributions have been utilized to search for the QCD critical point in heavy-ion collisions. In this paper, we report recent efficiency-corrected cumulants and cumulants ratios of the net- proton, net-kaon, and net-charge multiplicity distributions in Au+Au collisions at 7.7, 11.5, 14.5, 19.6, 27, 39, 62.4, and 200 GeV collected in the years 2010, 2011, and 2014 with STAR at RHIC. The centrality and energy dependence of the cumulants up to the fourth order, as well as their ratios, are presented. Furthermore, the comparisons with baseline calculations (Poisson) and non-c...

  15. 2006 Net Centric Operations Conference - Facilitating Net Centric Operations and Warfare

    Science.gov (United States)

    2006-03-16

    Moderator: Lt Col Kenneth Lang, USAF, Chief, Net Centric Transformational Operations, C4 Transformation Division (US JFCOM/J69) Panelists...of Interest (US JFCOM/J61) - Mr. Troy Turner, Section Head, C4 Interoperability (ACT) - COL Kelly Mayes, USA, Director, Campaign Planning...Deliverables NCAT NIF SCOPE Net Centric Assessment Tools (includes SCOPE & PFCs evaluation) Conceptual Architecture Framework Standards PFCs: Building Codes

  16. Linking a domain thesaurus to WordNet and conversion to WordNet-LMF

    OpenAIRE

    Toral, Antonio; Monachini, Monica; Soria, Claudia; Cuadros Oller, Montserrat; Rigau Claramunt, German; Bosma, Wauter; Vossen, Piek

    2010-01-01

    We present a methodology to link domain thesauri to general-domain lexica. This is applied in the framework of the KYOTO project to link the Species2000 thesaurus to the synsets of the English WordNet. Moreover, we study the formalisation of this thesaurus according to the ISO LMF standard and its dialect WordNet-LMF. This conversion will allow Species2000 to communicate with the other resources available in the KYOTO architecture. Peer Reviewed

  17. Continuous hemofiltration for anasarca: recovery of renal function after 71 liters of net ultrafiltration.

    Science.gov (United States)

    Prowle, J; Bellomo, R; Buckmaster, J; Gutteridge, G; Hart, G; Opdam, H; Silvester, W; Warrillow, S

    2008-04-01

    We report on a 64-year-old female presenting with anasarca secondary to volume loading in the setting of chronic liver disease, acute on chronic renal failure, circulatory failure and sepsis. Over 37 days, a net negative fluid balance of 71 L was achieved using continuous hemofiltration, with spontaneous recovery of urine output, vasopressor independence and resolution of coagulopathy. This case report underlines the pathophysiological role of tissue edema in the downward spiral of hepato-renal and cardio-renal dysfunction and illustrates that very large volumes of tissue fluid can be safely and effectively removed with continuous renal replacement therapy, thereby permitting recovery of organ function. To our knowledge, there have been no previous reports of such large volume net fluid removal by progressive ultrafiltration in the intensive care unit.

  18. The Net Contribution of Nuclear Power to the National Economy in Korea

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Manki; Kim, Seung-su; Lee, Jong Hee; Kim, Soo-eun [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    The objective of the study is to quantify the net contribution of nuclear power to the national economy in Korea focusing on the operating phase of nuclear power. This study is to see what would have happened to the Korean national economy, if all the nuclear power had been completely replaced with its substitute, coal power, providing a mechanism addressing a possible feedback between price and output on a national economy, triggered by the structural change in power sector. The role of nuclear power is estimated to be significant in terms of total output, GDP, price level, and labor employment in Korean economy. The net contribution of nuclear power estimated in this study can be recognized as positive externalities of nuclear power, which can be used to balance between positive externalities and negative externalities in the estimation of social cost of nuclear power, on which public concerns are substantially growing in the wake of the Fukushima nuclear power accident in Japan.

  19. Serotonin, ATRX, and DAXX Expression in Pituitary Adenomas

    DEFF Research Database (Denmark)

    Casar-Borota, Olivera; Botling, Johan; Granberg, Dan

    2017-01-01

    Differential diagnosis based on morphology and immunohistochemistry between a clinically nonfunctioning pituitary neuroendocrine tumor (NET)/pituitary adenoma and a primary or secondary NET of nonpituitary origin in the sellar region may be difficult. Serotonin, a frequently expressed marker...... in the NETs, has not been systematically evaluated in pituitary NETs. Although mutations in ATRX or DAXX have been reported in a significant proportion of pancreatic NETs, the mutational status of ATRX and DAXX and their possible pathogenetic role in pituitary NETs are unknown. Facing a difficult diagnostic...... case of an invasive serotonin and adrenocorticotroph hormone immunoreactive NET in the sellar region, we explored the immunohistochemical expression of serotonin, ATRX, and DAXX in a large series of pituitary endocrine tumors of different types from 246 patients and in 2 corticotroph carcinomas. None...

  20. Virtual Acts of Balance!

    DEFF Research Database (Denmark)

    Madsen, Anders Koed

    2013-01-01

    This paper presents an analysis of official documents and white papers pertaining to the two web-portals The Policy Grid Project and FEED that are launched by the UK and the EU respectively. The aim of the portals is to filter and synthesize information relevant for policy discussions and thereby...... Construction of Technology' and it shows how the framing of the portals and the concrete digital choices taken in relation to the infrastructure are influenced by the social intentions of relevant social groups as well as by the technical limitations on computers abilities to process semantic data....... It is especially emphasized how technical web-ontologies implicitly carries with them deeper philosophical ontologies about phanomena such as 'politic', 'scientific intentionality' and 'freedom'. The compromise between these technical influences and the social intentions is described as a 'virtual act of balance...

  1. Balance Toward Language Mastery

    Directory of Open Access Journals (Sweden)

    Virginia R. Heslinga

    2017-01-01

    Full Text Available Problems in attaining language mastery with students from diverse language backgrounds and levels of ability confront educators around the world. Experiments, research, and experience see positive effects of adding sign language in communication methods to pre-school and K-12 education. Augmentative, alternative, interactive, accommodating, and enriching strategies using sign language aid learners in balancing the skills needed to mastery of one language or multiple languages. Theories of learning that embrace play, drama, motion, repetition, socializing, and self-efficacy connect to the options for using sign language with learners in inclusive and mainstream classes. The methodical use of sign language by this researcher-educator over two and a half decades showed signing does build thinking skills, add enjoyment, stimulate communication, expand comprehension, increase vocabulary acquisition, encourage collaboration, and helps build appreciation for cultural diversity.

  2. Kin Selection - Mutation Balance

    DEFF Research Database (Denmark)

    Dyken, J. David Van; Linksvayer, Timothy Arnold; Wade, Michael J.

    2011-01-01

    Abstract Social conflict, in the form of intraspecific selfish "cheating" has been observed in a number of natural systems. However, a formal, evolutionary genetic theory of social cheating that provides an explanatory, predictive framework for these observations is lacking. Here we derive the kin...... selection-mutation balance, which provides an evolutionary null hypothesis for the statics and dynamics of cheating. When social interactions have linear fitness effects and Hamilton´s rule is satisfied, selection is never strong enough to eliminate recurrent cheater mutants from a population, but cheater...... lineages are transient and do not invade. Instead, cheating lineages are eliminated by kin selection but are constantly reintroduced by mutation, maintaining a stable equilibrium frequency of cheaters. The presence of cheaters at equilibrium creates a "cheater load" that selects for mechanisms of cheater...

  3. Balancing trust and power

    DEFF Research Database (Denmark)

    Broholm-Jørgensen, Marie; Guassora, Ann Dorrit; Reventlow, Susanne

    2017-01-01

    OBJECTIVE: Little is known about how strategies of retaining patients are acted out by general practitioners (GPs) in the clinical encounter. With this study, we apply Grimens' (2009) analytical connection between trust and power to explore how trust and power appear in preventive health checks...... from the GPs' perspectives, and in what way trust and power affect and/or challenge strategies towards retaining patients without formal education. DESIGN: Data in this study were obtained through semi-structured interviews with GPs participating in an intervention project, as well as observations...... of clinical encounters. RESULTS: From the empirical data, we identified three dimensions of respect: respect for the patient's autonomy, respect for professional authority and respect as a mutual exchange. A balance of respect influenced trust in the relationship between GP and patients and the transfer...

  4. [Balanced scorecard in health].

    Science.gov (United States)

    Leyton-Pavez, Carolina Elena; Huerta-Riveros, Patricia Carolina; Paúl-Espinoza, Iván Renato

    2015-01-01

    To evaluate the installation of strategies in the higher complexity hospitals (HMC, in Spanish) of public health in Chile starting from the results of the Balanced Scorecard (BSC), during the years 2011-2012. The implementation of the BSC is described, the strategies and indicators identified, and the results of the 57 HMC compared and analyzed. Starting from the comparison of the results it is discovered that the BSC allows to evaluate the installation of the strategies. Differences are identified in the installation of the strategies by geographical area, with North presenting a higher score (20.21), followed by Center (10.41) and South (19.50), which can be explained by the size and complexity of this establishments, variables that should be incorporated in the evaluation of the results of the BSC.

  5. Effects of Supplemental Energy on Protein Balance during 4-d Arctic Military Training.

    Science.gov (United States)

    Margolis, Lee M; Murphy, Nancy E; Martini, Svein; Gundersen, Yngvar; Castellani, John W; Karl, J Philip; Carrigan, Christopher T; Teien, Hilde-Kristin; Madslien, Elisabeth-Henie; Montain, Scott J; Pasiakos, Stefan M

    2016-08-01

    Soldiers often experience negative energy balance during military operations that diminish whole-body protein retention, even when dietary protein is consumed within recommended levels (1.5-2.0 g·kg·d). The objective of this study is to determine whether providing supplemental nutrition spares whole-body protein by attenuating the level of negative energy balance induced by military training and to assess whether protein balance is differentially influenced by the macronutrient source. Soldiers participating in 4-d arctic military training (AMT) (51-km ski march) were randomized to receive three combat rations (CON) (n = 18), three combat rations plus four 250-kcal protein-based bars (PRO, 20 g protein) (n = 28), or three combat rations plus four 250-kcal carbohydrate-based bars daily (CHO, 48 g carbohydrate) (n = 27). Energy expenditure (D2O) and energy intake were measured daily. Nitrogen balance (NBAL) and protein turnover were determined at baseline (BL) and day 3 of AMT using 24-h urine and [N]-glycine. Protein and carbohydrate intakes were highest (P energy intake above CON. Energy expenditure (6155 ± 515 kcal·d), energy balance (-3313 ± 776 kcal·d), net protein balance (NET) (-0.24 ± 0.60 g·d), and NBAL (-68.5 ± 94.6 mg·kg·d) during AMT were similar between groups. In the combined cohort, energy intake was associated (P energy intake (3723 ± 359 kcal·d, 2.11 ± 0.45 g protein·kg·d, 6.654 ± 1.16 g carbohydrate·kg·d) achieved net protein balance and NBAL during AMT. These data reinforce the importance of consuming sufficient energy during periods of high energy expenditure to mitigate the consequences of negative energy balance and attenuate whole-body protein loss.

  6. Renal aquaporins and water balance disorders

    DEFF Research Database (Denmark)

    Kortenoeven, Marleen; Fenton, Robert A.

    2013-01-01

    BACKGROUND: Aquaporins (AQPs) are a family of proteins that can act as water channels. Regulation of AQPs is critical to osmoregulation and the maintenance of body water homeostasis. Eight AQPs are expressed in the kidney of which five have been shown to play a role in body water balance; AQP1, AQP......2, AQP3, AQP4 and AQP7. AQP2 in particular is regulated by vasopressin. SCOPE OF REVIEW: This review summarizes our current knowledge of the underlying mechanisms of various water balance disorders and their treatment strategies. MAJOR CONCLUSIONS: Dysfunctions of AQPs are involved in disorders...... associated with disturbed water homeostasis. Hyponatremia with increased AQP levels can be caused by diseases with low effective circulating blood volume, such as congestive heart failure, or osmoregulation disorders such as the syndrome of inappropriate secretion of antidiuretic hormone. Treatment consists...

  7. Fuzzy net present value for engineering analysis

    Directory of Open Access Journals (Sweden)

    Ali Nazeri

    2012-10-01

    Full Text Available Cash flow analysis is one of the most popular methods for investigating the outcome of an economical project. The costs and benefits of a construction project are often involved with uncertainty and it is not possible to find a precise value for a particular project. In this paper, we present a simple method to calculate the net present value of a cash flow when both costs and benefits are given as triangular numbers. The proposed model of this paper uses Delphi method to figure out the fair values of all costs and revenues and then using fizzy programming techniques, it calculates the fuzzy net present value. The implementation of the proposed model is demonstrated using a simple example.

  8. Design and evaluation of net radiometers

    Science.gov (United States)

    Fritschen, Leo J.; Fritschen, Charles L.

    Net radiometer designs were evaluated with respect to long and short wave sensitivities and to the effect of ambient wind on the signal. The design features of the instrument with the best overall performance include: equal sensitivity to long and short wave radiation, a thermal pile which is thermally isolated from the frame, a white guard ring, pathways for internal circulation between the top and bottom hemispheres, and self-supporting windshields. The windshields have O-ring seals, a ball joint is provided for ease of leveling, and ample desiccant is enclosed in the mounting pipe. Under a high radiant load, the net radiometer signal decreased by 2.5, 3.7, and 4.3 percent at wind speeds of 12.5, 4.6, and 7.5 m/s.

  9. Multi-net optimization of VLSI interconnect

    CERN Document Server

    Moiseev, Konstantin; Wimer, Shmuel

    2015-01-01

    This book covers layout design and layout migration methodologies for optimizing multi-net wire structures in advanced VLSI interconnects. Scaling-dependent models for interconnect power, interconnect delay and crosstalk noise are covered in depth, and several design optimization problems are addressed, such as minimization of interconnect power under delay constraints, or design for minimal delay in wire bundles within a given routing area. A handy reference or a guide for design methodologies and layout automation techniques, this book provides a foundation for physical design challenges of interconnect in advanced integrated circuits.  • Describes the evolution of interconnect scaling and provides new techniques for layout migration and optimization, focusing on multi-net optimization; • Presents research results that provide a level of design optimization which does not exist in commercially-available design automation software tools; • Includes mathematical properties and conditions for optimal...

  10. Automatic pipeline operation using Petri Nets

    Energy Technology Data Exchange (ETDEWEB)

    Moreira, Guilherme O. [PETROBRAS TRANSPORTE S.A., Rio de Janeiro, RJ (Brazil)

    2009-07-01

    A pipeline operation requires several actions, attention and time from the control room operator in each of its operating phases. This article proposition is to use automation as something more than a remote control, drastically reducing the number of repetitive and routine actions needed from the operator to start and stop the system, granting more time for system supervision, decision making during critical conditions and avoiding errors caused due to the need of several actions being executed in a short period of time. To achieve these objectives the pipeline operation will be modeled as a Petri Net consisting of states, event and actions. A methodology for converting this Petri Net into a Ladder controller code will also be proposed. (author)

  11. AstroNet-II International Final Conference

    CERN Document Server

    Masdemont, Josep

    2016-01-01

    These are the proceedings of the "AstroNet-II International Final Conference". This conference was one of the last milestones of the Marie-Curie Research Training Network on Astrodynamics "AstroNet-II", that has been funded by the European Commission under the Seventh Framework Programme. The aim of the conference, and thus this book, is to communicate work on astrodynamics problems to an international and specialised audience. The results are presented by both members of the network and invited specialists. The topics include: trajectory design and control, attitude control, structural flexibility of spacecraft and formation flying. The book addresses a readership across the traditional boundaries between mathematics, engineering and industry by offering an interdisciplinary and multisectorial overview of the field.

  12. EVo: Net Shape RTM Production Line

    Directory of Open Access Journals (Sweden)

    Sven Torstrick

    2016-04-01

    Full Text Available EVo research platform is operated by the Center for Lightweight-Production-Technology of the German Aerospace Center in Stade. Its objective is technology demonstration of a fully automated RTM (Resin Transfer Molding production line for composite parts in large quantities. Process steps include cutting and ply handling, draping, stacking, hot-forming, preform-trimming to net shape, resin injection, curing and demolding.

  13. Status of KM3NeT

    Directory of Open Access Journals (Sweden)

    Riccobene G.

    2016-01-01

    Full Text Available The recent observation of cosmic neutrinos by IceCube has pushed the quest towards the identification of cosmic sources of high-energy particles. The KM3NeT Collaboration is now ready to launch the massive construction of detection units to be installed in deep sea to build a km-cubic size neutrino telescope. The main elements of the detector, the status of the project and the expected perfomances are briefly reported.

  14. A Petri Nets Model for Blockchain Analysis

    OpenAIRE

    Pinna, Andrea; Tonelli, Roberto; Orrú, Matteo; Marchesi, Michele

    2017-01-01

    A Blockchain is a global shared infrastructure where cryptocurrency transactions among addresses are recorded, validated and made publicly available in a peer- to-peer network. To date the best known and important cryptocurrency is the bitcoin. In this paper we focus on this cryptocurrency and in particular on the modeling of the Bitcoin Blockchain by using the Petri Nets formalism. The proposed model allows us to quickly collect information about identities owning Bitcoin addresses and to re...

  15. AREVA net income: 649 million euros

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-03-15

    This document presents the financial statements for 2006 of Areva group: net income: 649 million euros; backlog up by 24.6% to 25.6 billion euros; steady growth of sales revenue: + 7.3%1 to 10.863 billion euros; operating income of 407 million euros: excellent divisional performance and constitution of a significant provision for the OL3 project in Finland; dividend proposed to Annual General Meeting of Shareholders: 8.46 euros per share.

  16. Net-Faim: distributed computation of aerial images

    Science.gov (United States)

    Hollerbach, Uwe

    1998-06-01

    Simulation of aerial images is an important part of modern microchip manufacturing, but computation of the image of an entire mask is a challenging problem requiring a large amount of memory and CPU time. Fortunately, it is possible to decompose the large problem of computing the full image into many smaller, mostly independent, sub-problems. In this paper, one particular decomposition is described and implemented. The target platform is a heterogeneous group of networked workstations. The program, net-faim, was designed to be robust, to scale well with available resources, and to place modest demands on participating workstations. All of these design criteria have been realized. The overall performance of the distributed computation is linearly proportional to the sum of the performances of the individual processors, up to a rather high level of parallelism. Robustness is achieved by not relying on any one server to complete a given task; instead, if an idle server is available, the task is sent out to the idle server even if it has previously been sent to another server. The task is only retired when a server returns the completed answer. This 'paranoid' method of processing tasks has the pleasant side effect of doing automatic dynamic load balancing. The results of runs with several different configurations, both of participating workstations and of sub- domain sizes, are displayed.

  17. Document analysis with neural net circuits

    Science.gov (United States)

    Graf, Hans Peter

    1994-01-01

    Document analysis is one of the main applications of machine vision today and offers great opportunities for neural net circuits. Despite more and more data processing with computers, the number of paper documents is still increasing rapidly. A fast translation of data from paper into electronic format is needed almost everywhere, and when done manually, this is a time consuming process. Markets range from small scanners for personal use to high-volume document analysis systems, such as address readers for the postal service or check processing systems for banks. A major concern with present systems is the accuracy of the automatic interpretation. Today's algorithms fail miserably when noise is present, when print quality is poor, or when the layout is complex. A common approach to circumvent these problems is to restrict the variations of the documents handled by a system. In our laboratory, we had the best luck with circuits implementing basic functions, such as convolutions, that can be used in many different algorithms. To illustrate the flexibility of this approach, three applications of the NET32K circuit are described in this short viewgraph presentation: locating address blocks, cleaning document images by removing noise, and locating areas of interest in personal checks to improve image compression. Several of the ideas realized in this circuit that were inspired by neural nets, such as analog computation with a low resolution, resulted in a chip that is well suited for real-world document analysis applications and that compares favorably with alternative, 'conventional' circuits.

  18. Readmissions at a public safety net hospital.

    Directory of Open Access Journals (Sweden)

    Eri Shimizu

    Full Text Available OBJECTIVE: We aimed to determine factors related to avoidability of 30-day readmissions at our public, safety net hospital in the United States (US. METHODS: We prospectively reviewed medical records of adult internal medicine patients with scheduled and unscheduled 30-day readmissions. We also interviewed patients if they were available. An independent panel used pre-specified, objective criteria to adjudicate potential avoidability. RESULTS: Of 153 readmissions evaluated, 68% were unscheduled. Among these, 67% were unavoidable, primarily due to disease progression and development of new diagnoses. Scheduled readmissions accounted for 32% of readmissions and most (69% were clinically appropriate and unavoidable. The scheduled but avoidable readmissions (31% were attributed largely to limited resources in our healthcare system. CONCLUSIONS: Most readmissions at our public, safety net hospital were unavoidable, even among our unscheduled readmissions. Surprisingly, one-third of our overall readmissions were scheduled, the majority reflecting appropriate management strategies designed to reduce unnecessary hospital days. The scheduled but avoidable readmissions were due to constrained access to non-emergent, expensive procedures that are typically not reimbursed given our system's payor mix, a problem which likely plague other safety net systems. These findings suggest that readmissions do not necessarily reflect inadequate medical care, may reflect resource constraints that are unlikely to be addressable in systems caring for a large burden of uninsured patients, and merit individualized review.

  19. Protein crystallization image classification with elastic net

    Science.gov (United States)

    Hung, Jeffrey; Collins, John; Weldetsion, Mehari; Newland, Oliver; Chiang, Eric; Guerrero, Steve; Okada, Kazunori

    2014-03-01

    Protein crystallization plays a crucial role in pharmaceutical research by supporting the investigation of a protein's molecular structure through X-ray diffraction of its crystal. Due to the rare occurrence of crystals, images must be manually inspected, a laborious process. We develop a solution incorporating a regularized, logistic regression model for automatically evaluating these images. Standard image features, such as shape context, Gabor filters and Fourier transforms, are first extracted to represent the heterogeneous appearance of our images. Then the proposed solution utilizes Elastic Net to select relevant features. Its L1-regularization mitigates the effects of our large dataset, and its L2- regularization ensures proper operation when the feature number exceeds the sample number. A two-tier cascade classifier based on naïve Bayes and random forest algorithms categorized the images. In order to validate the proposed method, we experimentally compare it with naïve Bayes, linear discriminant analysis, random forest, and their two-tier cascade classifiers, by 10-fold cross validation. Our experimental results demonstrate a 3-category accuracy of 74%, outperforming other models. In addition, Elastic Net better reduces the false negatives responsible for a high, domain specific risk. To the best of our knowledge, this is the first attempt to apply Elastic Net to classifying protein crystallization images. Performance measured on a large pharmaceutical dataset also fared well in comparison with those presented in the previous studies, while the reduction of the high-risk false negatives is promising.

  20. The arithmetic symmetry of monoatomic 2-nets.

    Science.gov (United States)

    Fadda, G; Zanzotto, G

    2000-01-01

    A recent paper [Pitteri & Zanzotto (1998). Acta Cryst. A54, 359-373] has proposed a framework for the study of the 'arithmetic symmetry' of multilattices (discrete triply periodic point sets in the affine space). The classical approach to multilattice symmetry considers the well known 'space groups', that is, the groups of affine isometries leaving a multilattice invariant. The ensuing classification counts 219 affine conjugacy (or isomorphism) classes of space groups in three dimensions, and 17 classes in two dimensions ('plane groups'). The arithmetic criterion gives a finer classification of multilattice symmetry than space (or plane) groups do. This paper is concerned with the systematic investigation of the arithmetic symmetry of multilattices in the simplest nontrivial case, that is, monoatomic 2-nets (planar lattices with two identical atoms in their unit cell). We show the latter to belong to five distinct arithmetic types. We also give the complete description of a fundamental domain for the action of the global symmetry group of 2-nets on the space of 2-net metrics.

  1. Role of high dose octreotide LAR for the treatment of GEP-NETs

    Directory of Open Access Journals (Sweden)

    Giulia M. Franchi

    2009-03-01

    Full Text Available Neuroendocrine Tumours (NETs are a heterogeneous group of rare neoplasms that account for 0,5% of all malignancies. The increased incidence observed in the last few decades may be accounted for by increased awareness, improved diagnostic tools and a revision in the definition. The main primary sites are the gastro-entero-pancreatic (GEP tract (62-67%, and the lung (22-27%. In patients with GEP-NETs, the strongest predictor of 5-years survival is the staging. An adequate clinical management of GEP-NETs should be multidisciplinary and should aim at assuring a good quality of life. Somatostatin (sst analogues are widely used in these tumours, which often express sst receptors, since they are demonstrated to reduce clinical symptoms and tumour growth. Herein we explore the usefulness of doubling octreotide LAR dose in selected patients after escaping from symptoms control and/or tumour stabilization in course of treatment with standard dose.

  2. A 530-GHz balanced mixer

    OpenAIRE

    Chattopadhyay, Goutam; Rice, Frank; Miller, David; LeDuc, Henry G.; Zmuidzinas, Jonas

    1999-01-01

    We report on the design and performance of a 530-GHz balanced SIS mixer, the first balanced mixer in this frequency range. This quasi-optical balanced mixer utilizes a cross-slot antenna on a hyperhemispherical substrate lens with eight superconductor-insulator-superconductor (SIS) junctions and a 180° lumped element IF hybrid circuit. The local oscillator (LO) and the radio frequency (RF) signal, orthogonal in polarization to each other, are coupled to the mixer using a wire-grid polarizer. ...

  3. Radar channel balancing with commutation

    Energy Technology Data Exchange (ETDEWEB)

    Doerry, Armin Walter

    2014-02-01

    When multiple channels are employed in a pulse-Doppler radar, achieving and maintaining balance between the channels is problematic. In some circumstances the channels may be commutated to achieve adequate balance. Commutation is the switching, trading, toggling, or multiplexing of the channels between signal paths. Commutation allows modulating the imbalance energy away from the balanced energy in Doppler, where it can be mitigated with filtering.

  4. [Nutrition, acid-base metabolism, cation-anion difference and total base balance in humans].

    Science.gov (United States)

    Mioni, R; Sala, P; Mioni, G

    2008-01-01

    The relationship between dietary intake and acid-base metabolism has been investigated in the past by means of the inorganic cation-anion difference (C(+)(nm)-A(-)(nm)) method based on dietary ash-acidity titration after the oxidative combustion of food samples. Besides the inorganic components of TA (A(-)(nm)-C(+)(nm)), which are under renal control, there are also metabolizable components (A(-)(nm)-C(+)(nm)) of TA, which are under the control of the intermediate metabolism. The whole body base balance, NBb(W), is obtained only by the application of C(+)(nm)-A(-)(nm) to food, feces and urine, while the metabolizable component (A(-)(nm)-C(+)(nm)) is disregarded. A novel method has been subsequently suggested to calculate the net balance of fixed acid, made up by the difference between the input of net endogenous acid production: NEAP = SO(4)(2-)+A(-)(m)-(C(+)(nm)-A(-)(nm)), and the output of net acid excretion: NAE = TA + NH(4)(+) - HCO(3)(-). This approach has been criticized because 1) it includes metabolizable acids, whose production cannot be measured independently; 2) the specific control of metabolizable acid and base has been incorrectly attributed to the kidney; 3) the inclusion of A-m in the balance input generates an acid overload; 4) the object of measurement in making up a balance has to be the same, a condition not fulfilled as NEAP is different from NAE. Lastly, by rearranging the net balance of the acid equation, the balance of nonmetabolizable acid equation is obtained. Therefore, any discrepancy between these two equations is due to the inaccuracy in the urine measurement of metabolizable cations and/or anions.

  5. When Do States Balance Power?

    DEFF Research Database (Denmark)

    Hariri, Jacob Gerner; Wivel, Anders

    2010-01-01

    This paper explores the logic of balancing in structural realist theory. Arguably, the durability of the unipolar moment is a challenge to the logic of balancing. The paper uses the tools of microeconomics to build a mathematical model of structural realism. The simple model reiterates...... the structural realist prediction that the weaker states should balance the unipole. Under a slight model extension, it is shown that efforts to balance in separate capabilities always tends to offset each other. Under this extension, the durability of the unipolar moment is in fact consistent...

  6. Monthly Water Balance Model Hydrology Futures

    Science.gov (United States)

    Bock, Andy; Hay, Lauren E.; Markstrom, Steven; Atkinson, R. Dwight

    2016-01-01

    A monthly water balance model (MWBM) was driven with precipitation and temperature using a station-based dataset for current conditions (1950 to 2010) and selected statistically-downscaled general circulation models (GCMs) for current and future conditions (1950 to 2099) across the conterminous United States (CONUS) using hydrologic response units from the Geospatial Fabric for National Hydrologic Modeling (http://dx.doi.org/doi:10.5066/F7542KMD). Six MWBM output variables (actual evapotranspiration (AET), potential evapotranspiration (PET), runoff (RO), streamflow (STRM), soil moisture storage (SOIL), and snow water equivalent (SWE)) and the two MWBM input variables (atmospheric temperature (TAVE) and precipitation (PPT)) were summarized for hydrologic response units and aggregated at points of interest on a stream network. Results were then organized into the Monthly Water Balance Hydrology Futures database, an open-access database using netCDF format (http://cida-eros-mows1.er.usgs.gov/thredds/dodsC/nwb_pub/).  Methods used to calibrate and parameterize the MWBM are detailed in the Hydrology and Earth System Sciences (HESS)  paper "Parameter regionalization of a monthly water balance model for the conterminous United States" by Bock and others (2016).  See the discussion paper link in the "Related External Resources" section for access.  Supplemental data files related to the plots and data analysis in Bock and others (2016) can be found in the HESS-2015-325.zip folder in the "Attached Files" section.  Detailed information on the files and data can be found in the ReadMe.txt contained within the zipped folder. Recommended citation of discussion paper:Bock, A.R., Hay, L.E., McCabe, G.J., Markstrom, S.L., and Atkinson, R.D., 2016, Parameter regionalization of a monthly water balance model for the conterminous United States: Hydrology and Earth System Sciences, v. 20, 2861-2876, doi:10.5194/hess-20-2861-2016, 2016

  7. Molecular Imaging Radiotherapy: Theranostics for Personalized Patient Management of Neuroendocrine Tumors (NETs).

    Science.gov (United States)

    Oberg, Kjell

    2012-01-01

    Neuroendocrine tumors (NETs) possess unique features including expression of peptide hormone receptors as well as the capacity to concentrate and take up precursor forms of amines and peptides making hormones that are stored in secretory granules within the tumor cells (APUD). The expression of somatostatin receptors on tumor cells have been widely explored during the last two decades starting with (111)In-DTPA-Octreotide as an imaging agent followed by (68)Ga-DOTATOC/TATE positron emission tomography scanning. The new generation of treatment includes (90)Yttrium-DOTATOC/DOTATATE as well as (177)Lutetium-DOTATOC/DOTATATE/DOTANOC treatment of various subtypes of NETs. The objective response rate by these types of PRRT is in the range of 30-45% objective responses with 5-10% grade 3/4 toxicity mainly hematologic and renal toxicity. The APUD mechanism is another unique feature of NETs which have generated an interest over the last two decades to develop specific tracers including (11)C-5HTP, (18)F-DOPA and (11)C-hydroxyefedrin. These radioactive tracers have been developed in centres with specific interest in NETs and are not available everywhere. (111)In-DTPA-Octreotide is still the working horse in diagnosis and staging of metastatic NETs, but will in the future be replaced by (68)Ga-DOTATOC/DOTATATE PET/CT scanning which provide higher sensitivity and specificity and is also more convenient for the patient because it is a one-stop-procedure. Both (90)Yttrium-DOTATOC/DOTATATE as well as (177)Lutetium-DOTATOC/DOTATATE are important new therapies for malignant metastatic NETs. However, the precise role in the treatment algorithm has to be determined in forthcoming randomized trials.

  8. Bed net ownership in Kenya: the impact of 3.4 million free bed nets

    Directory of Open Access Journals (Sweden)

    Vulule John

    2010-06-01

    Full Text Available Abstract Background In July and September 2006, 3.4 million long-lasting insecticide-treated bed nets (LLINs were distributed free in a campaign targeting children 0-59 months old (CU5s in the 46 districts with malaria in Kenya. A survey was conducted one month after the distribution to evaluate who received campaign LLINs, who owned insecticide-treated bed nets and other bed nets received through other channels, and how these nets were being used. The feasibility of a distribution strategy aimed at a high-risk target group to meet bed net ownership and usage targets is evaluated. Methods A stratified, two-stage cluster survey sampled districts and enumeration areas with probability proportional to size. Handheld computers (PDAs with attached global positioning systems (GPS were used to develop the sampling frame, guide interviewers back to chosen households, and collect survey data. Results In targeted areas, 67.5% (95% CI: 64.6, 70.3% of all households with CU5s received campaign LLINs. Including previously owned nets, 74.4% (95% CI: 71.8, 77.0% of all households with CU5s had an ITN. Over half of CU5s (51.7%, 95% CI: 48.8, 54.7% slept under an ITN during the previous evening. Nearly forty percent (39.1% of all households received a campaign net, elevating overall household ownership of ITNs to 50.7% (95% CI: 48.4, 52.9%. Conclusions The campaign was successful in reaching the target population, families with CU5s, the risk group most vulnerable to malaria. Targeted distribution strategies will help Kenya approach indicator targets, but will need to be combined with other strategies to achieve desired population coverage levels.

  9. Net Clinical Benefit of Antithrombotic Therapy in Patients With Atrial Fibrillation and Chronic Kidney Disease

    DEFF Research Database (Denmark)

    Bonde, Anders Nissen; Lip, Gregory Y H; Kamper, Anne-Lise

    2014-01-01

    BACKGROUND: The balance between stroke reduction and increased bleeding associated with antithrombotic therapy among patients with atrial fibrillation (AF) and chronic kidney disease (CKD) is controversial. OBJECTIVES: This study assessed the risk associated with CKD in individual CHA₂DS₂-VASc...... (Congestive heart failure; Hypertension; Age ≥75 years; Diabetes mellitus; previous Stroke, transient ischemic attack, or thromboembolism; Vascular disease; Age 65 to 74 years; Sex category) strata and the net clinical benefit of warfarin in patients with AF and CKD in a nationwide cohort. METHODS...

  10. Net Shape Rapid Manufacturing Using Nano Encapsulated Powders Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase II program is developing NET Shape components from Encapsulated Powders. Significant advances in Phase I for various materials and in net shape processing...

  11. GALILEO PROBE NET FLUX RADIOMETER DATA V1.0

    Data.gov (United States)

    National Aeronautics and Space Administration — The Galileo Probe Net Flux Radiometer (NFR) measured net and upward radiation fluxes in Jupiter's atmosphere between about 0.44 bars and 14 bars, using five spectral...

  12. Observations of NC stop nets for bottlenose dolphin takes

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — To observe the NC stop net fishery to document the entanglement of bottlenose dolphins and movement of dolphins around the nets.

  13. RadNet Air Data From Little Rock, AR

    Science.gov (United States)

    This page presents radiation air monitoring and air filter analysis data for Little Rock, AR from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  14. HANPP Collection: Global Patterns in Net Primary Productivity (NPP)

    Data.gov (United States)

    National Aeronautics and Space Administration — The Global Patterns in Net Primary Productivity (NPP) portion of the HANPP Collection maps the net amount of solar energy converted to plant organic matter through...

  15. RadNet Air Data From Pittsburgh, PA

    Science.gov (United States)

    This page presents radiation air monitoring and air filter analysis data for Pittsburgh, PA from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  16. RadNet Air Data From Montgomery, AL

    Science.gov (United States)

    This page presents radiation air monitoring and air filter analysis data for Montgomery, AL from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  17. RadNet Air Data From Toledo, OH

    Science.gov (United States)

    This page presents radiation air monitoring and air filter analysis data for Toledo, OH from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  18. Global Estimated Net Migration Grids by Decade: 1970-2000

    Data.gov (United States)

    National Aeronautics and Space Administration — The Global Estimated Net Migration by Decade: 1970-2000 data set provides estimates of net migration over the three decades from 1970 to 2000. Because of the lack of...

  19. Java EE 7 development with NetBeans 8

    CERN Document Server

    Heffelfinger, David R

    2015-01-01

    The book is aimed at Java developers who wish to develop Java EE applications while taking advantage of NetBeans functionality to automate repetitive tasks. Familiarity with NetBeans or Java EE is not assumed.

  20. RadNet Air Data From Honolulu, HI

    Science.gov (United States)

    This page presents radiation air monitoring and air filter analysis data for Honolulu, HI from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.