WorldWideScience

Sample records for neoplasias malignas primarias

  1. Neoplasias malignas: caracterización

    Directory of Open Access Journals (Sweden)

    Freddie Hernández Cisneros

    1997-02-01

    Full Text Available Se realizó un estudio transversal con el objetivo de caracterizar a los pacientes con neoplasias malignas en un área de salud desde marzo de 1994 hasta agosto del mismo año; el universo de estudio estuvo representado por 75 pacientes diagnosticados con algún tipo de afección maligna y el registro primario de los datos, por una encuesta con variables seleccionadas; se procesó la información de una forma computadorizada. Se encontraron como resultados más importantes: una mayor incidencia en el grupo de edad de 50 años y más; un 56 % fumaba y un 17,33 % ingería bebidas alcohólicas; las 3 localizaciones más frecuentes fueron: mama, cuello del útero y piel, y se detectaron deficiencias llamativas en la promoción y la prevención de estas enfermedades.: A cross-sectional study was carried out, with the aim of characterizing the patients with malignant neoplasms in a health area, from March 1994 to August of the same year; the universe of study was represented by 75 patients diagnosed with some kind of malignant disease, and the primary score of the data, by means of a survey with selected variables; information was processed in a computed way. The most important results found, were: the highest incidence in the 50 years old or more age group; the 56 % smoked, and the 17.33 % drank alcoholic beverages; the three most frequent sites, were: breast, cervix uteri and skin, and also outstanding defficiencies were detected in the promotion and prevention of these diseases.

  2. Patología maligna tiroidea. Hospital Sabogal, Callao

    Directory of Open Access Journals (Sweden)

    Juan Oré

    2004-03-01

    Full Text Available Objetivos: Determinar las características clínicas del cáncer de tiroides encontrados en la población del Callao. Diseño: Estudio descriptivo retrospectivo. Material y Métodos: Se revisó las historias clínicas de las intervenciones quirúrgicas de la glándula tiroides en el Hospital Nacional Alberto Sabogal Sologuren (HNASS, en el periodo enero de 2000 a diciembre de 2002, cuyo resultado por anatomía patológica fue compatible con neoplasia maligna de dicha glándula. Resultados: Las 45 neoplasias malignas primarias de tiroides encontradas representaron 34,2% de la patología tiroidea operada en el periodo en estudio. El carcinoma papilar se presentó en 100% de los pacientes de sexo masculino y en 82% del sexo femenino; en la mujer, los carcinomas folicular, medular y linfoma representaron 10,3%, 5,1% y 2,6%, respectivamente. El grupo etáreo con mayor incidencia fue entre 50 y 69 años, con una edad promedio de 53 años. Dentro de los diferentes tipos de neoplasias malignas, el más frecuente fue el papilar con 38 casos (84,4%, seguido de los carcinomas folicular y medular con 8,9% y 4,4%, respectivamente. El síntoma más frecuente fue el aumento de volumen (61,5%, seguido de dolor (15,4%, disfagia (10,8% y disfonía (9,2%; 29,6% se encontraba en estadio I y 59,1% en estadio II; sólo 11,4% estaba en estadio III. Conclusiones: El predominio de casos en mujeres del carcinoma papilar y la clínica asociada, fueron acordes con lo descrito en la literatura.

  3. Neoplasias malignas de glândulas salivares: estudo retrospectivo = Malignant neoplasms of salivary glands: retrospective study

    Directory of Open Access Journals (Sweden)

    Barbosa, Renata Pereira de Sousa et al.

    2005-01-01

    Full Text Available Este trabalho objetivou identificar a ocorrência de neoplasias malignas em glândulas salivares de pacientes dos hospitais de referência no tratamento de Câncer do Estado da Paraíba no período de 1998 a 2003. Foi realizado um estudo retrospectivo pelo método indireto, através da análise de 914 prontuários arquivados do Hospital Dr. Napoleão Laureano, em João Pessoa-PB, e do Centro de Cancerologia Ulisses Pinto, em Campina Grande-PB. Encontrou-se 29 casos de neoplasias malignas de glândulas salivares, dos quais 53,6% acometeram indivíduos do gênero masculino e 46,4% do feminino; a faixa etária com maior número de casos foi de 61-80 anos com 48,3%. A glândula parótida apresentou maior prevalência com 48,3%, sendo o tipo neoplásico com maior representação da amostra o Carcinoma adenóide cístico com 58,6%

  4. Multiple malignant primary neoplasms in patients with gastric neoplasms in the health district of León Neoplasias primarias malignas múltiples en pacientes con cáncer gástrico en el área sanitaria de León

    Directory of Open Access Journals (Sweden)

    A. Muela Molinero

    2006-12-01

    Full Text Available Objectives: we analyzed the characteristics of patients with gastric tumors diagnosed with multiple malignant primary neoplasm (MMPN in the Health District of León. Material and methods: using the information in the Tumor Registry at León Hospital patients selected were those with gastric neoplasms diagnosed between 1993 and 2002. A follow-up was performed until December 31, 2004, and the characteristics of patients diagnosed with a second neoplasm were analyzed. Results: MMPN prevalence was 1,96%; 56% of patients had a history of cancer in first-degree relatives. The most frequent second neoplasms were digestive (26% and urologic (21%; 87% of patients were diagnosed with a second neoplasm within the first two years. No significative differences in survival were observed among patients with synchronous or metachronous MMPN. Conclusions: MMPN in patients with gastric neoplasms is a relevant problem. While external carcinogenic agents could act as promoters in the development of second neoplasms, these patients seem to have a genetic background favoring the development of MMPN. Secondary prevention is the best measure to avoid MMPN development.Objetivos: analizar las características de los pacientes con tumores gástricos diagnosticados de una neoplasia primaria maligna múltiple (NPMM en el área sanitaria de León. Pacientes y método: utilizando los datos del Registro de Tumores del Hospital de León se han seleccionado aquellos pacientes con tumores gástricos diagnosticados entre 1993 y 2002. Se realizó un seguimiento hasta el 31 de diciembre de 2004 analizando las características de los pacientes diagnosticados de una segunda neoplasia durante el periodo de seguimiento. Resultados: la prevalencia de NPMM fue del 1,96%. El 56% de los pacientes tenían antecedentes oncológicos en familiares de primer grado. Las segundas neoplasias más frecuentes fueron las digestivas (26% y las urológicas (21%. El 87% de los pacientes fueron

  5. Trombose venosa profunda e neoplasia mamária maligna: relato de caso em idosa

    Directory of Open Access Journals (Sweden)

    Eliton Edmilson Couto

    2017-08-01

    Full Text Available A Trombose Venosa Profunda (TVP é caracterizada pela formação de trombos no interior de veias profundas, mais comum nos mem¬bros inferiores (80 a 95% dos casos. A incidência da doença, no Brasil, mostra-se em torno de 0,6 por 1.000 habitantes/ano. A literatura descreve alguns fatores principais no processo de formação dos trombos: estase sanguínea, lesões do endotélio e estados de hipercoagulabilidade. As neoplasias também são reconhecidas como fatores de risco independentes para TVP. Como complicação grave da TVP, em sua fase aguda, cita-se a embolia pulmonar e, tardiamente, a síndrome pós-trombótica. O objetivo do presente estudo é relatar um caso clínico de uma paciente do sexo feminino, idosa, portadora de hipertensão arterial sistêmica, diabetes mellitus tipo 2 e dislipidemia, em uso irregular das medicações. Concomitantemente, há 3 meses, a paciente foi diagnosticada com neoplasia mamária maligna, ainda sem início do tratamento. Ao exame físico a paciente apresentou-se com dor em membro inferior direito, sem hiperemia, com edema e sinal de Homams positivo. Como tratamento para TVP foi proposto uso de anticoagulante oral, e a paciente segue internada, em repouso, há 6 dias. Diante do caso apresentado, cabe destacar que é de suma importância compreender os fatores de risco para TVP, bem como suas alterações fisiológicas no organismo, o que é de extrema importância para o diagnóstico correto e o sucesso terapêutico de cada caso.

  6. Estudo histoquímico de proteínas fibrilares da matriz extracelular em neoplasias mamárias benignas e malignas na espécie canina

    Directory of Open Access Journals (Sweden)

    Ana Maria Cristina Rabello Pinto da Fonseca Martins

    2002-01-01

    Full Text Available A finalidade do presente trabalho foi estudar algumas das proteínas fibrilares da matriz extracelular de 54 neoplasias mamárias benignas e malignas na espécie canina, utilizando métodos histoquímicos: Picrosirius associado à polarização para fibras colágenas , método de Gordon - Sweats para fibras reticulares e método de Weigert com e sem oxidação para fibras elásticas. Evidenciou-se na matriz uma grande variabilidade na quantidade, distribuição e características dos componentes matriciais presentes nos diferentes tipos de neoplasias. Detectou-se, assim, colágeno I, III e elementos do sistema elástico, distribuídos diferentemente nas neoplasias benignas e malignas. O método Picrosirius simples e associado à polarização permitiu a visualização do colágeno sob a forma de fibras espessas distribuídas irregularmente no estroma dos carcinomas e de modo mais ordenado e regular nas neoplasias benignas e, fibras mais finas, em menor quantidade, irregularmente e aleatoriamente dispostas nos carcinomas e regularmente nas neoplasias benigna. Sob luz polarizada os feixes de fibras colágenas , apresentaram diferentes comprimentos, avermelhados ou amarelados e fortemente birrefringentes, sugerindo serem colágeno tipo I e, entremeando as fibras, algumas mais finas ,pálidas, esverdeadas e fracamente birrefringentes, presumivelmente colágeno tipo III. Em áreas condrometaplásicas, tanto nos carcinomas como nas neoplasias benignas notou-se que os feixes colágenos apresentavam-se com fibras finas, paralelas, limitando regiões estreitas onde os condrócitos se aninhavam, e, rodeando esta área, feixes de fibras espessas, anastomosadas, dispostas irregularmente nos carcinomas e ordenadamente e paralelas nas neoplasias benignas. Sob luz polarizada, essa população entre condrócitos era formada por fibras pálidas e amareladas, sugerindo padrão tipo II e na faixa circundante, feixes fortemente birrefringentes, sugerindo o padr

  7. Estudio prospectivo de la cefalea en pacientes con hemopatías malignas

    OpenAIRE

    Marín Lahoz, Juan

    2013-01-01

    Objetivo: describir las cefaleas en pacientes ingresados con neoplasias hematológicas, identificar los factores asociados a cefaleas secundarias graves. Estudio observacional prospectivo. Se incluyen 30 casos de cefalea correspondientes a 23 pacientes. Ocho cefaleas son primarias y 22 secundarias. Diez de estas, son secundarias a patología grave o potencialmente grave: encefalopatía hipertensiva, neoplasia intracraneal, hemorragia intracraneal, infección cefálica, trombosis venosa, fiebre tum...

  8. Mortalidade por neoplasias no Brasil (1980/1983/1985: agrupamento dos Estados, comportamento e tendências Mortality from neoplasms in Brazil (1980/1983/1985: grouping by State, behaviors and tendencies

    Directory of Open Access Journals (Sweden)

    Fábio Gonçalves Pinto

    1991-08-01

    Full Text Available Examinou-se a mortalidade por neoplasias no Brasil, utilizando-se dados oficiais do Ministério da Saúde, abrangendo 26 Unidades da Federação e 13 diferentes localizações neoplásicas, para os anos de 1980, 1983 e 1985. As Análises de Agrupamento e de Componentes Principais revelaram comportamento heterogêneo entre regiões do país, com relação às 13 variáveis estudadas, sendo que os principais elementos discriminantes foram as neoplasias malignas da traquéia/brônquio/pulmão, seguidas das do estômago, esôfago, cólon e pâncreas. Análises complementares evidenciaram tendência de crescimento das taxas de mortalidade para as neoplasias malignas da próstata (17,74%, da traquéia/brônquio/pulmão(15,22%, da mama (11,32%, do pâncreas (10,23%, do cólon (8,08%, do colo uterino (6,45% e da laringe (6,36%. Houve redução da mortalidade por neoplasias benignas/carcinoma "in situ"/ outras (27,37%, por neoplasias malignas no reto sigmóide/ânus (7,67%, do estômago (5,31%, de outro local do útero não especificado (2,56%, por leucemia (0,70% e por neoplasias malignas do esôfago (0,44%. As neoplasias malignas do estômago foram a principal causa de morte por câncer no Brasil, representando 21,30% do total médio, seguidas das neoplasias malignas da traquéia/brônquio/pulmão(17,49% do total médio. Destacam-se os altos índices de mortalidade por neoplasias malignas do esôfago no Estado do Rio Grande do Sul.Mortality caused by neoplasms in Brazil was examined by means of official Ministry of Health data covering 26 of the Federal Units and 13 different tumoral sites and referring to the years 1980,1983 and 1985. Both cluster analyses and those of principal components have shown heterogenous behaviour as between the different regions of the country in relation to the 13 variants studied. The main discriminatory elements are the trachea/bronchus/lung malign neoplasms followed by those of stomach, pancreas, colon and larynx

  9. Identification of progenitor cancer stem cell in lentigo maligna melanoma.

    Science.gov (United States)

    Bongiorno, M R; Doukaki, S; Malleo, F; Aricò, M

    2008-07-01

    The potential role of stem cells in neoplasia has aroused considerable interest over the past few years. A number of known biologic characteristics of melanomas support the theory that they may originate in a mutated stem cell. Melanocytic stem cell markers have been described recently. Moreover, the CD133 cells that show surface markers for CD34 are stem cells primitive. These stem cells are capable of differentiating into neurons, glia, keratinocytes, smooth muscle cells, and melanocytes in vitro. The identification of cancer stem/initiating cells with a crucial role in tumor formation may open up new pharmacologic perspectives. The purpose of this study is to detect the expression of CD133 and CD34, two putative markers of cancer stem cells in the lentigo maligna melanoma. Thirty cases of lentigo maligna melanoma were analyzed using indirect immunohistochemical staining. The vast majority of the samples analyzed showed the presence of rare cells, which were clearly positive for CD133 and CD34. Strong CD133 and CD34 staining was found in the outer root sheath of the mid-lower hair follicles, intermixed with atypical melanocytes extending along layers of the hair follicles. A number of these staminal cells were adjacent and intermixed with melanoma cells. This study supports the stem cell origin of this tumor and suggests that the precursor of the melanoma in question is a stem-like cell rather than the primitive melanoblast committed to be exclusively involved in melanocytic differentiation.

  10. Suplementação com imunoestimulante em cadelas com neoplasia mamária maligna: aspectos hematológicos e bioquímicos

    Directory of Open Access Journals (Sweden)

    Vilma F. Oliveira

    Full Text Available RESUMO: Os alimentos funcionais têm sido empregados como adjuvantes no tratamento do câncer de mama. Neste estudo avaliaram-se as respostas hematológicas e bioquímicas clínicas à ação de um alimento funcional administrado a cadelas com diagnóstico de neoplasia mamária maligna. Após a mastectomia, 16 cadelas foram divididas em dois grupos: suplementadas (S e não suplementadas (NS com um composto comercial contendo Saccharomyces cerevisiae, mananoligossacarídeos e nutracêuticos. Ambos grupos receberam tratamento quimioterápico com doxorrubicina e carboplatina, alternadamente, em intervalos de 21 dias, por oito sessões, totalizando 168 dias de tratamento. As avaliações clínicas e laboratoriais foram realizadas nos momentos de aplicação do tratamento. Os resultados dos perfis hematológico (hemograma, leucograma e plaquetograma e bioquímico sérico (ureia, creatinina, albumina, bilirrubina total e direta, alanina aminotransferase, fosfatase alcalina e gama glutamiltransferase - GGT foram analisados pelo teste de Kruskall Wallis. No grupo S comprovou-se elevação do peso corporal e não foram observados transtornos gastrointestinais ou outros sinais de alteração clínica ao longo do tratamento. Diferentemente no grupo NS, ocorreu perda de peso e alterações clínicas, como diarreia e vômito. No quadro hematológico, constatou-se leucopenia por linfopenia no grupo de cadelas NS e preservação do valores dentro dos parâmetros considerados normais para a espécie no grupo S. Dentre todas as variáveis da bioquímica clínica, constatou-se apenas a elevação da atividade sérica da GGT nos animais do grupo NS, sem alterações no grupo S. Conclui-se que cadelas com neoplasia mamária quando suplementadas com com alimento funcional imunoestimulante apresentam melhor condição clínica, hematológica e dos níveis bioquímicos, particularmente da GGT.

  11. Reflectance Confocal Microscopy in Lentigo Maligna.

    Science.gov (United States)

    Gamo, R; Pampín, A; Floristán, U

    2016-12-01

    Lentigo maligna is the most common type of facial melanoma. Diagnosis is complicated, however, as it shares clinical and dermoscopic characteristics with other cutaneous lesions of the face. Reflectance confocal microscopy is an imaging technique that permits the visualization of characteristic features of lentigo maligna. These include a disrupted honeycomb pattern and pagetoid cells with a tendency to show folliculotropism. These cells typically have a dendritic morphology, although they may also appear as round cells measuring over 20μm with atypical nuclei. Poorly defined dermal papillae and atypical cells may be seen at the dermal-epidermal junction and can form bridges resembling mitochondrial structures. Other characteristic findings include junctional swelling with atypical cells located around the follicles, resembling caput medusae. Reflectance confocal microscopy is a very useful tool for diagnosing lentigo maligna. Copyright © 2016 AEDV. Publicado por Elsevier España, S.L.U. All rights reserved.

  12. Dermatologic symptoms associated with gastrointestinal neoplasia

    Directory of Open Access Journals (Sweden)

    Beata Młynarczyk-Bonikowska

    2017-03-01

    Full Text Available Gastrointestinal tumors are among the most common neoplastic causes of death worldwide. Presence of characteristic skin lesions can allow faster diagnosis and therapy and this way can increase the probability of a cure. In the paper we present the most important paraneoplastic syndromes that can coexist with gastrointestinal malignancy including colon, gastric, esophagus and pancreatic cancers. We take into account genetic syndromes such as Cowden syndrome, familial atypical multiple mole melanoma syndrome (FAMMM (melanoma/pancreatic cancer, Clarke Howel-Evans, Peutz-Jeghers, Muir-Torre, Gardner syndromes and acquired syndromes such as acantosis nigricans maligna, tripe palms, Leser-Trelat, Bazex, hypertrichosis languinosa, erythema gyratum repens , carcinoid and glucagonoma syndrome. We also include cutaneous metastases and coexistence of neoplasia in some cases of dermatomyositis.

  13. Oral tumors in dogs: clinical aspects, exfoliative cytology and histopathology Neoplasias orais em cães: avaliação dos aspectos clínicos, histopatologia e citologia esfoliativa

    Directory of Open Access Journals (Sweden)

    Cláudia Ronca Felizzola

    1999-09-01

    Full Text Available In order to establish the diagnosis and prognosis of tumors of the oral cavity, a comparative study was carried out in 130 dogs considering age, sex, breed, clinical aspects, exfoliative cytology as well as histopathology. Exfoliative cytology revealed: 100% negative for benign non-odontogenic tumors, 97.91% negative benign odontogenic tumors and 77.92% positive for malignant tumors. Histopathology showed: 59.23% malignant tumors (33.08% malignant melanoma, 9.23% squamous cell carcinoma, 5.38% osteosarcoma, 2.31% fibrosarcoma, 2.31% angiosarcoma, 1.54% malignant mesenchymal tumors, 1.54% malignant fibrohistiocytoma, 1.54% lymphoma, 0.77% leyomyosarcoma, 0.77%% epithelioid sarcoma and 0.77% angiofibrosarcoma; 36.92% benign odontogenic tumors (25.38% peripheral odontogenic fibroma, 10.0% ossifyng fibroma and 1.54% odontoma in addition to 3.85% benign non-odontogenic tumors (1.54% fibroma, 0.77% plasmocytoma, 0.77% pilomatrixoma and 0.77% giant tumor cells. These results permit us to conclude that exfoliative cytology was an efficient, safe, quick and noninvasive method and could be used for early evaluation of oral cancer.Objetivou-se o estudo comparativo em tumores de cavidade bucal de animais de espécie canina de acordo com sexo, faixa etária, raça, aspectos clínicos, citologia esfoliativa e histopatologia, para estabelecer diagnóstico dessas neoplasias, tendo sido utilizados 130 cães, encaminhados ao Hospital Veterinário (HOVET da Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo. Os resultados obtidos na citologia esfoliativa foram: 100% de negativos para neoplasias benignas não odontogênicas; 97,91% de negativos para neoplasias benignas odontôgenicas e 77,92% de positivos para neoplasias malignas. Obtiveram-se os seguintes resultados no exame histopatológico: neoplasias malignas - 59,23% (melanoma 33,08%, carcinoma epidermóide 9,23%, osteossarcoma 5,38%, fibrossarcoma 2,31%, angiossarcoma 2

  14. Avaliação do uso de extrato de timo (timulina em pacientes com neoplasia maligna submetidos ao tratamento cirúrgico

    Directory of Open Access Journals (Sweden)

    Célia Regina de Oliveira Garritano

    Full Text Available OBJETIVO: Avaliar a ação da timulina em pacientes com neoplasia maligna, submetidos ao tratamento, com e sem quimioterapia e radioterapia complementar (QT/RT. MÉTODO: Estudo retrospectivo realizado em 50 pacientes, analisando as variações das taxas de leucócitos, linfócitos totais e da relação de linfócitos CD4/CD8 após imunoestimulação com timulina. RESULTADOS: No grupo submetido à QT/RT ocorreu um aumento do número de leucócitos após seis meses em 43,33% dos casos, e em 83,33% após 12 meses. Com relação aos linfócitos totais, após seis meses, 63,33% apresentaram níveis maiores, e depois de 12 meses isto ocorreu em casos 90% dos casos. A relação de linfócitos CD4/CD8 mostrou um aumento em 66,66%, e em 90% depois após 6 e 12 meses respectivamente. A análise estatística se mostrou significante com o teste de ANOVA one way. No grupo não submetido à QT/RT a elevação dos níveis de leucócitos ocorreu em 85% dos pacientes aos seis meses e em 90% aos 12 meses. As taxas de linfócitos se elevaram em 60% dos casos em seis meses e em 85% após 12 meses. A relação CD4/CD8 se tornou maior tanto aos seis como aos 12 meses em 65%. A análise estatística mostrou relevância com o teste "t" de Student e o de ANOVA one way. Não houve necessidade de interrupção dos ciclos de QT/RT e nenhum paciente referiu intolerância à timulina. CONCLUSÃO: O uso da timulina foi capaz de restaurar a resposta imune, reduzir os danos imunossupressores e colaterais induzidos pela terapia antineoplásica e não apresentou efeitos colaterais.

  15. La neoplasia sólida-pseudopapilar del páncreas como entidad enigmática

    Directory of Open Access Journals (Sweden)

    Eduardo Blanco Faramiñán

    Full Text Available El tumor sólido-pseudopapilar del páncreas, conocido también como tumor de Frantz, es una rara enfermedad. Afecta principalmente a mujeres jóvenes, no blancas. Tiene componentes sólidos y quísticos. Constituye una neoplasia maligna con un pronóstico, generalmente alentador. Realizamos una revisión de la literatura con el objetivo de actualizar algunos puntos clave acerca del tema. Se incluyeron para la búsqueda las siguientes palabras claves: “tumor sólido-quístico”, “tumor quístico papilar”, “pseudopapilar”, “sólido y quístico”, “tumor de páncreas”, “tumor pancreático”, “neoplasia del páncreas”, “neoplasia pancreática”, “sólido pseudopapilar” y “tumor de Frantz”. Los acápites que desarrollamos son patogénesis, biología molecular, patología, características clínicas, imaginología y diagnóstico, tratamiento y por último pronóstico. Existen algunos aspectos no bien dilucidados en estos tumores. Por ejemplo, se necesitan más investigaciones en áreas como patogénesis, biología molecular y tratamiento no quirúrgico.

  16. Diagnóstico de masas intracraneales primarias por medio imagenológicos Diagnosis of intracranial masses using imaging techniques

    Directory of Open Access Journals (Sweden)

    Samael Suero Almonte

    2012-02-01

    Full Text Available Se realizó un estudio descriptivo, longitudinal y transversal que incluyó a los pacientes operados de neoplasia del sistema nervioso central intracraneal en el Hospital General Docente "Abel Santamaría Cuadrado " de la provincia Pinar del Río, durante el período comprendido desde el 1 de enero de 2010 hasta el 31 de diciembre del mismo año. Se incluyeron todos los pacientes egresados a los que se les había realizado tomografía computarizada o resonancia magnética y poseían diagnóstico histológico postoperatorio de neoplasia primaria del sistema nervioso central (SNC intracraneal. Se concluyó que las neoplasias primarias fueron más frecuentes en el sexo femenino y en grupo de edad de 70 años y más. Las localizaciones más frecuentes de las neoplasias primarias del sistema nervioso central fueron las masas intraaxiales y supratentoriales y el tipo histológico más prevalente fue el glioma. Todas se comportaron imagenológicamente captantes de contraste, con poca hemorragia y calcificación intermediamente con efecto de masa y hipointensas en T1 hiperintensas en T2.A descriptive, longitudinal and cross-sectional study including the patients operated on intracranial central nervous system neoplasm was carried out at "Abel Santamaria Cuadrado" University Hospital, Pinar del Rio during January 1, 2010 to December 31, 2010. All patients discharged from the hospital with Computerized Axial Tomography or Magnetic Resonance Imaging and having post-operative histological diagnosis of primary intracranial neoplasm of the central nervous system (CNS were included. Primary neoplasm was the most frequent in female sex and in the age-bracket of 70 years old or older. The most repeated localizations of primary neoplasm in the CNS were in intra-axial and supratentorial masses, glioma was the most prevailing histological type. Contrast examinations could be performed in all masses, presenting not much hemorrhage, with intermediate

  17. Neoplasias primárias múltiplas em pacientes com câncer colorretal Multiple primary neoplasms in colorectal cancer patients

    Directory of Open Access Journals (Sweden)

    Marcelo de Souza CURY

    2000-04-01

    Full Text Available Introdução - A presença de uma segunda neoplasia maligna, tendo sítio e histologia diferentes da primeira, define o conceito de neoplasias primárias múltiplas. Com o aumento da sobrevida dos pacientes com câncer, houve um aumento de neoplasias primárias múltiplas. Este estudo objetiva avaliar a freqüência de neoplasias primarias múltiplas em pacientes com diagnóstico de câncer colorretal do Setor de Oncologia da Disciplina de Gastroenterologia da Universidade Federal de São Paulo. Pacientes e Métodos - No período de 1993 a 1998, 145 pacientes com câncer colorretal foram acompanhados no Setor de Oncologia da Disciplina de Gastroenterologia da Universidade Federal de São Paulo. Destes, cinco pacientes (3,4% tinham neoplasias primárias múltiplas. O segundo tumor foi confirmado por exame histológico, sendo excluídas as possibilidades de metástase. Resultados - A idade média dos doentes com neoplasias primárias múltiplas foi de 60,6 anos, quatro eram do sexo feminino e um do masculino, três apresentaram doença no reto, um no cólon direito e um no cólon esquerdo. Os outros sítios foram mama, útero, útero e vagina, pele e lábio. Um paciente foi a óbito e os outros estão em acompanhamento, sendo que dois, há mais de três anos. Dois pacientes tinham sido submetidos a radioterapia pélvica antes do aparecimento da neoplasia colorretal. Em um paciente o tumor colorretal antecedeu o outro câncer e em quatro apareceu posteriormente ao diagnóstico da outra neoplasia primária. Discussão - A prevalência de neoplasias primárias múltiplas foi de 3,4%, sendo maior no sexo feminino. Câncer de endométrio foi o outro tumor maligno mais freqüente. Quarenta por cento dos nossos pacientes foram submetidos a radioterapia. Acreditamos ser importante o acompanhamento dos pacientes para o diagnóstico precoce de uma nova neoplasia em qualquer paciente que já tenha apresentado um câncer.Introduction - Multiple primary

  18. Incidencia de las lesiones cutáneas malignas faciales

    Directory of Open Access Journals (Sweden)

    Jorge Luis Zequeira Peña

    2003-04-01

    Full Text Available Se realiza un estudio de las lesiones malignas de la piel facial en el Servicio de Cirugía Maxilofacial del Hospital "Manuel Ascunce Domenech" de Camagüey en los años 2000 y 2001. La información se obtuvo de 148 historias clínicas con el diagnóstico de lesiones malignas de la piel, de las cuales 42 correspondieron a lesiones de localización facial. La entidad que nos ocupa fue mayor en pacientes mayores de 50 años de edad, blancos, masculinos, con predominio en el tercio medio facial. Los principales tipos histológicos fueron: el carcinoma basocelular y el espinocelular, pero con mayor predominio en el primero. Se revisa el tema y se comparan nuestros resultados con los de otros autores.

  19. Histiocitosis maligna: Reporte de un caso

    Directory of Open Access Journals (Sweden)

    Oscar Ruiz

    2004-12-01

    Full Text Available Paciente varón de 14 años, procedente de Huancayo, que presenta un mes antes de su hospitalización intolerancia gástrica, ictericia, fiebre y síndrome linfoproliferativo. Se encontró en los exámenes de laboratorio pancitopenia severa por hemofagocitosis. El diagnóstico hematológico y anatomopatológico fue histiocitosis maligna. Se presenta este caso por ser una entidad infrecuente y una emergencia médica.

  20. Lues maligna in an HIV-infected patient

    Directory of Open Access Journals (Sweden)

    Passoni Luiz Fernando Cabral

    2005-01-01

    Full Text Available We report such a case of malignant syphilis in a 42-year-old HIV-infected man, co-infected with hepatitis B virus, who presented neurolues and the classical skin lesions of lues maligna. The serum VDRL titer, which was 1:64 at presentation, increased to 1:2,048 three months after successful therapy with penicillin, decreasing 15 months later to 1:8.

  1. Neoplasias de Cavidad nasal y senos paranasales en caninos

    Directory of Open Access Journals (Sweden)

    Giovanni Torres

    2008-10-01

    Full Text Available Las neoplasias de cavidad nasal y senos paranasales en caninos son de escasa presentación; llegan tan sóloal 1.5% de los quistes diagnosticados en esta especie.Con referencia al total de tumores del tracto respiratorio representan entre el 60 y el 80%. Son más comunes en caninos de nariz larga, no existe predilección por género; por el comportamiento, las neoplasias que se desarrollanen la cavidad nasal y senos paranasales son benignas y malignas, siendo estas últimas las más frecuentes. Teniendo en cuenta el tejido de origen pueden ser epiteliales, mesenquimales y de otro origen como los linfomas y el tumor venéreo transmisible. La apariciónde la sintomatología se asocia con la capacidad de obstruir las vías aéreas, la invasión y destrucción local de tejido. En general los signos clínicos asociados consistenen: dificultad respiratoria, estornudo, secreciónnasal, hemorragia nasal y la presencia de masas de características variadas en tamaño y forma. El diagnóstico se basa en signos clínicos, evaluación citológica e histológica de las lesiones. Esta última es 100% diagnóstica, para el tratamiento se utiliza la extracción quirúrgica combinada con terapia de radiación y quimioterapia.

  2. Expresión de oncogén RET/PTC en tiroiditis de hashimoto y microcarcinomas papilares tiroideos mediante estudio inmunohistoquímico

    OpenAIRE

    Pareja Megía, María Jesús

    2001-01-01

    El desarrollo de neoplasias malignas en pacientes afectados por tiroiditis de Hashimoto es un importante problema clínico-terapéutico del que todavía se desconocen algunos aspectos etiopatogénicos. Los enfermos generalmente tienen un buen pronóstico, pero en ocasiones pueden desarrollar hipotiroidismo. Además, estos pacientes tienen un mayor riesgo para desarrollar neoplasias malignas como linfomas y carcinomas. La alta incidencia de carcinoma papilar en la tiroiditis de Hashimoto hace consid...

  3. Tuberculose ileocecal isolada simulando neoplasia maligna e doença de Crohn Isolated ileocecal tuberculosis simulating malignant neoplasia and Crohn's disease

    Directory of Open Access Journals (Sweden)

    S.H. BROMBERG

    2001-06-01

    Full Text Available OBJETIVO: No Brasil, a tuberculose ileocecal isolada, na ausência de tuberculose pulmonar ativa ou cicatrizada, é rara, sendo freqüentemente confundida com neoplasia e a doença de Crohn. MÉTODOS: Os autores apresentam oito doentes com essas características, tratados por cirurgia, em período de 20 anos. A dor abdominal na fossa ilíaca direita foi o principal sintoma (100%, seguido da presença de perda de peso (62,5%, febre, náuseas e vômitos e fadiga em 50% dos doentes. Sete enfermos (87,5% apresentaram massa palpável na fossa ilíaca direita. A duração média dos sintomas foi de 14,7 meses, variando de 5 a 36 meses. Todas as lesões foram detectadas pelo enema opaco e mimetizavam aspecto neoplásico. A colonoscopia foi realizada em três doentes, evidenciando lesões sub-oclusivas da região íleo-cecal em dois; as biópsias foram sugestivas de tuberculose, não sendo possível diferenciá-las da doença de Crohn. RESULTADOS: Seis enfermos com diagnóstico presuntivo de neoplasia foram submetidos a cirurgia eletiva, realizando-se neles a colectomia direita clássica. Os outros dois, com suspeita de tuberculose, foram operados na vigência de obstrução intestinal, sendo submetidos a ressecção limitada (ileocecectomia. O estudo anatomopatológico estabeleceu o diagnóstico final pelo encontro de necrose caseosa e de bacilos álcool ácido-resistentes no intestino ou nos linfonodos. A evolução pós-operatória foi satisfatória, com pequena morbidade resolvida clinicamente. Posteriormente, todos os doentes receberam o esquema tríplice por 12 meses, variando a droga de acordo com a época do tratamento. CONCLUSÃO: Apesar de rara, a tuberculose hipertrófica ileocecal isolada freqüentemente é confundida com neoplasias e com a doença de Crohn, devendo ser lembrada no diagnóstico diferencial das lesões localizadas no quadrante inferior direito do abdome.BACKGROUND: Isolated ileocecal involvement by tuberculosis in the absence

  4. Incidencia de neoplasias hematológicas en el Área Metropolitana de Bucaramanga, 2000-2004

    Directory of Open Access Journals (Sweden)

    Claudia Janeth Uribe Pérez

    2008-07-01

    Full Text Available Resumen SummaryAntecedentes: Las lesiones hematooncológicas son un grupo de neoplasias generadas por alteraciones células progenitoras hematopoyéticas. Este tipo de lesiones afectan a la población en general, con un porcentaje importante de ocurrencia en la población infantil. En el Área Metropolitana de Bucaramanga (AMB estos trastornos se ubican dentro de las lesiones malignas más frecuentes region (2000 - 2004. Metodología: El Registro Poblacional del AMB realiza un proceso de búsqueda y verificación IACR, activa de los casos de cáncer en la población residente AMB desde el 2000. Luego de los procesos de validación, los casos son codificados y digitados en CanReg-4 con el cual se estiman frecuencias y tasas de software. Este informe tiene datos verificados y actualizados que incluyen los obtenidos en el proceso de validación de egreso hospitalario y registros de mortalidad. Resultados: Entre 2000 y 2004 se captaron 620 casos de neoplasias hematolinfoides ubicándose en los primeros lugares tanto en hombres como en mujeres, con un mayor número de casos en los hombres especialmente por casos de leucemia linfoide. Se encuentra tasa cruda de 10.9 casos Conclusión: Comparando con las cifras del proyecto , el comportamiento de las neoplasias hematológicas en esta región es similar a lo estimado para el Área Metropolitana de Bucaramanga

  5. Epidemiología descriptiva de las neoplasias malignas en niños

    Directory of Open Access Journals (Sweden)

    Fajardo-Gutiérrez Arturo

    1999-01-01

    Full Text Available El objetivo de este estudio es presentar la epidemiología descriptiva del cáncer en los niños menores de 15 años a nivel mundial y nacional. Se realizó una revisión de la literatura internacional y nacional de los artículos publicados sobre cáncer en los niños, seleccionando aquellos que trataran los aspectos epidemiológicos de tiempo, lugar y persona y analizándose tanto la incidencia como la mortalidad por cáncer en niños. La incidencia mundial es de 100 a 150 casos x 10(6 niños/año. La incidencia específica varía de acuerdo al tipo cáncer, el país o región que se estudie. El patrón latinoamericano de neoplasias lo constituyen las leucemias, los linfomas y los tumores del sistema nervioso central (TSNC; en el norteamericano y europeo los TSNC ocupan el segundo lugar; y en el africano predominan los linfomas. La incidencia es mayor en los menores de 5 años en el medio urbano y existe un incremento de 1% anual de cánceres en los niños de Estados Unidos de América. La mortalidad por cáncer en niños ha disminuido de forma importante principalmente en los países desarrollados, como Estados Unidos e Inglaterra; en los subdesarrollados permanece estable o hay una leve disminución. La incidencia es mayor en países desarrollados; sin embargo, en los países subdesarrollados puede estar subestimada. Aún hay muchos datos que se desconocen sobre la epidemiología del cáncer en el niño, por lo que son necesarios más estudios.

  6. Reticulo-endotheliomatose maligna

    Directory of Open Access Journals (Sweden)

    C. Magarinos Torres

    1932-08-01

    Full Text Available A spindle-cell sarcoma (fig. 5 apparently originating from the dura (fig. 4 was found at the autopsy of a male, mulato, 17 years of age. The bones of the skull (occipital and both parietals were penetrated and destroyed (fig. 1 and 2. The nervous tissue was not penetrated, the only change in the brain being a depressed area where the tumor was included. Metastatic nodules were found in the liver (fig. 3,hepatic lymphnodes (fig. 14, spleen (fig. 12 and suprarenal bodies (fig. 15. The structure, however, in all those different locations was that of a typical endothelioma (figs. 8, 11 and 13. The cells are of large and moderate size, of polyhedral form, with vesicular nuclei, diminutive nucleoli and clear cytoplasm. (Figs. 6 and 8. They are arranged about a central lumen which represents a rudimentary vessel (figs. 9 and 13. Other areas are composed of cells without concentric arrangement (figs. 4 and 10. In small areas, the colums of liver cells are marginated in one side by typical sinusoids, while in the other side tumor cells arranged about a narrow lumen are seen suggesting a pathological (neoplastic sinusoid (figs. 7 and 9. The case is considered as a multiple diffuse endothelioma. The origin of the tumor is referred to the reticulo-endothelial apparatus of the liver, the spleen, the suprarenal bodies and the lymph nodes, the structure being rather uniform in those organs. In the dura, the endothelioma reproduces the structure and presents the general character of a fibroblastic sarcoma; in some places, however, the structure of endothelioma could be found (fig.6. It corresponds to the reticulo-endotheliomatosis maligna according to Puhr's grouping of progressive changes in the reticulo-endothelial apparatus which is a follows: 1. HYPERPLASTIC - 1. Mnnocytic leukemia. 2. a Aleukemic reticulosis (Goldschmid and Isaac. b Idiopathic sarcoma of skin (Kaposi. c Cutaneous sarcoid (Spiegler. 3. Secretory reticulosis. a Gaucher's disease. b

  7. El diagnóstico por la imagen de las enfermedades de las glándulas salivales

    OpenAIRE

    Paz Expósito, Francisco

    2002-01-01

    Las lesiones de las glándulas salivales son relativamente frecuentes, presentando una patología tan diversa como la de cualquier otro sistema orgánico. La mayoría de las lesiones son inflamatorias, otras son de origen litiásico, algunas tienen una patogenia incierta que pueden confundirse con neoplasias malignas y, por último, hay un amplio espectro de neoplasias tanto benignas como malignas. La mayoría de los agrandamientos de las glándulas salivales están causados por procesos inflamator...

  8. Amenorrea primaria

    Directory of Open Access Journals (Sweden)

    Alfredo Jácome Roca

    1988-08-01

    , colagenosis, desnutrición, enfermedades crónicas o malignas, etc.

    Como uno de los objetos de esta revisión es presentar la casuística más interesante observada en el Hospital Universitario San Ignacio, profundizaremos en las diversas causas comprendidas en esta clasificación, a medida que se vayan describiendo los diferentes pacientes y diagnósticos.

    En cualquier caso, la amenorrea primaria es un trastorno poco común que resulta de errores fetales en el desarrollo gonadal, gonadoductal y genital en el 60% de los casos. La mitad de estos están constituidos por síndromes de disgenesia gonadal (típica tipo Turner, mixta y pura, un tercio por disgenesia mulleriana y un sexto, por errores en el desarrollo genital. El restante 40% de las mujeres tiene amenorrea primaria por hipogonadismo hipogonadotrófico, otras endocrinopatías, Síndrome de “ovarios resistentes” (folículos insensibles a las gonadotrofinas, ovarios esclero-quísticos, pubertad retrasada idiopática o sinequias endometriales. Es evidente que la mitad de los pacientes con amenorrea primaria presentan enfermedad ovárica primaria, fuera de otros trastornos gonadales en donde hay cariotipo XY o enfermedades tumorales1.

    La aparición de la menarquia normal presupone entonces no sólola ausencia de anormalidades anatómicas sino también un eje hipotálamo-hipóI.i.siB”bvario intacto. Recordemos que en el hipotálamo se produce la gonadorrelina u hormona liberadora de gonadotrofinas, también denominada con las siglas Gn-RH (gonadotrophin releasing hormone o LH-RH (Luteinizing hormone-releasing hormonel, aunque en realidad se produce la liberación de ambas gonadotrofinas LH y FSH; para obtener un efecto “liberador” se requiere de una secreción pulsátil, mientras que la secreción -o administración- sostenida, produciría el efecto contrario de inhibición de las gonadotrofinas, por lo que las gonadorrelinas de acción larga (como la Buserrelina se utilizan en la terap

  9. Factores psicológicos y sociales en las neoplasias malignas pediátricas Psychological and social factors in malignant neoplasia in children

    Directory of Open Access Journals (Sweden)

    2007-03-01

    Full Text Available This research was conducted to assess some psychologic and social factors in families with children with malignant neoplasia. A cross-sectional and correlation study was performed in a group of 38 mothers of patients aged 0-18 months, who were seen in “Juan Manuel Márquez” Children Hospital, in Marianao, in June and July 2005. The following techniques were applied: Family Performance Perception Test (FPPT, social support questionnaire (SSQ, and confrontation scale (CS. The information obtained was processed by means of the SPSS statistical program in its version for Window 98. The results showed that most of the families were functional, and that mothers needed a lot of social support, mainly of emotional support. It was concluded that there was no dependence between the family functioning and the variables which with it was related; most of the mothers felt satisfied with the social support received, and the confrontation strategies they used the most were to focus their attention on the positive, and to worry and concentrate themselves on solving the problem.

  10. Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma using Mel-5 immunostaining: an update from the University of Minnesota.

    Science.gov (United States)

    Newman, Jessica; Beal, Matthew; Schram, Sarah E; Lee, Peter K

    2013-12-01

    Mohs micrographic surgery (MMS) is gaining acceptance as a treatment for lentigo maligna (LM) and lentigo maligna melanoma (LMM), especially with the use of melanocyte-staining immunohistochemical (IHC) stains. In 2006, we reported our 4-year experience with Mel-5 immunostaining, with only one recurrence noted in 200 patients after a mean follow-up of 38.4 months.(1) OBJECTIVES: We present an update regarding our 13-year experience with the use of Mel-5. Patients with primary or recurrent LM or LMM (n = 260) underwent MMS with Mel-5; 174 were followed up to evaluate for recurrence, with a mean follow-up of 34 months. The 200 patients described in the initial case series from 1999 to 2003 were also followed. Of the 460 patients treated from January 1999 to December 2011, five recurrences were noted in four patients; one in the initial case series and four in this new, updated series, including one re-recurrence from the initial series. One melanoma-related death occurred in a patient intermittently lost to follow-up. MMS with Mel-5 immunostaining continues to yield excellent results in the treatment of LM and LMM. © 2013 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc.

  11. Expressão imunoistoquímica do p16 e do PDGFR-beta no adenocarcinoma gástrico

    OpenAIRE

    Rodrigo Pozza Pinto

    2005-01-01

    O adenocarcinoma de estômago foi a principal causa de morte por neoplasia maligna no mundo durante grande parte do século XX e atualmente é superado somente pelas neoplasias epiteliais malignas de pulmão. Cerca de 750.000 novos casos são diagnosticados anualmente. Apresenta grande variação geográfica, sendo suas maiores incidências encontradas no Japão, América do Sul, Europa Oriental e Oriente Médio. É duas vezes mais freqüente em homens do que em mulheres; é pouco comum antes dos 40 anos e ...

  12. Conhecimento e prática de enfermeiros no cuidado a pacientes com feridas tumorais malignas

    Directory of Open Access Journals (Sweden)

    Glenda Agra

    2017-09-01

    Full Text Available Introdução: As feridas tumorais malignas representam uma angústia para pacientes que enfrentam uma doença terminal, uma vez que são lesões desfigurantes, sem possibilidades de cicatrização e que desenvolvem sintomas de difícil controle. O objetivo foi verificar o conhecimento e prática de enfermeiros no cuidado a pacientes com feridas tumorais malignas. Materiais e Métodos: Trata-se de um estudo exploratório, descritivo, quantitativo realizado com 22 enfermeiros de um hospital da Paraíba, Brasil, durante o período de abril a junho de 2016. O instrumento foi um questionário estruturado baseado no protocolo do Ministério da Saúde. Para a análise dos dados utilizou-se estatística descritiva e literatura pertinente. Resultados: Os resultados permitiram identificar que os enfermeiros apresentam lacunas no conhecimento de conteúdos e técnicas sobre avaliação e tratamento de pacientes com feridas neoplásicas. Além disso, constatou-se que os enfermeiros não executam alguns cuidados pertinentes a essa clientela. Discussão: Acredita-se que essas fragilidades estejam relacionadas ao dimensionamento de pessoal, déficit no conhecimento, inabilidade em realizar cuidados com feridas tumorais malignas, falta de insumos que auxiliem na avaliação e tratamento da lesão, inexistência de protocolo institucional para o cuidado com essas lesões. Conclusões: Desse modo, a instituição lócus da pesquisa precisa investir em educação permanente, a fim de treinar a equipe de enfermagem para o acompanhamento de pacientes com feridas tumorais malignas, adquirir materiais necessários e implantar protocolos assistenciais que norteiem a prática de métodos avaliativos e terapêuticos para o cuidado com pessoas com essas lesões, familiares e cuidadores. Como citar este artigo: Agra G, Medeiros MVS, Brito DTF, Sousa ATO, Formiga NS, Costa MML. Conhecimento e prática de enfermeiros no cuidado a pacientes com feridas tumorais malignas. Rev

  13. Hipertermia maligna no Brasil: análise da atividade do hotline em 2009 Hipertermia maligna en Brasil: análisis de la actividad del hotline en 2009 Malignant hyperthermia in Brazil: analysis of hotline activity in 2009

    OpenAIRE

    Helga Cristina Almeida da Silva; Clea dos Santos Almeida; Julio Cézar Mendes Brandão; Cleyton Amaral Nogueira e Silva; Mariana Elisa Pinto de Lorenzo; Carolina Baeta Neves Duarte Ferreira; André Hosoi Resende; Sara Rocha Barreira; Priscilla Antunes de Almeida; Leonardo Henrique Cunha Ferraro; Alexandre Takeda; Kátia Ferreira de Oliveira; Talitha Gonçalez Lelis; Alexandre Hortense; Marcelo Vaz Perez

    2013-01-01

    JUSTIFICATIVA E OBJETIVOS: Hipertermia maligna (HM) é doença farmacogenética, com reação hipermetabólica anormal a anestésicos halogenados e/ou relaxantes musculares despolarizantes. Desde 1991 há um serviço hotline de atendimento telefônico para HM no Brasil, disponível 24 horas por dia, em São Paulo. Este artigo analisa a atividade do serviço brasileiro de hotline para HM em 2009. MÉTODOS: Análise prospectiva de todas chamadas telefônicas paria maligna (HM) é doença farmacogenética, com rea...

  14. Primary plasmacytoma of the thyroid gland: a case report of a rare neoplasia Plasmocitoma da glândula tireoide: relato de caso de uma rara neoplasia

    Directory of Open Access Journals (Sweden)

    Eduardo Cambruzzi

    2012-08-01

    Full Text Available Extramedullary plasmacytoma comprises 3%-5% of all plasma cell neoplasms, and approximately 80% of the cases occur in the upper respiratory tract. Primary thyroid plasmacytomas (PTP are rare tumors. The authors report a case of PTP in a male patient with dyspnea and dysphagia. Physical examination and computerized tomography (CT scan revealed a solid tumor affecting the thyroid gland, measuring 12 cm in its greatest dimension. Surgical biopsy was performed. Microscopy revealed a hypercellular malignant neoplasm composed of round plasmacytoid cells arranged in solid nests, which showed a positive immunoexpression for CD138, epithelial membrane antigen (AME, kappa light chains and multiple myeloma oncogene 1 (MUM1. The diagnosis of PTP was accordingly established.O plasmocitoma extramedular constitui 3%-5% de todas as neoplasias de plasmócitos e aproximadamente 80% dos casos ocorrem no trato respiratório superior. Plasmocitomas primários da tireoide (TPP são tumores raros. Os autores relatam um caso de TPP em um paciente masculino referindo dispneia e disfagia. O exame físico e a tomografia computadorizada revelaram tumor sólido comprometendo a glândula tireoide, medindo 12 cm na maior dimensão, o qual foi submetido à biópsia cirúrgica. À microscopia, foi identificada neoplasia maligna hipercelular constituída por células redondas/plasmocitoides dispostas em ninhos sólidos, as quais exibiam imunoexpressão positiva para CD138, antígeno da membrana epitelial (AME, cadeias leves kappa e oncogene mieloma múltiplo 1 (MUM1. O diagnóstico de TPP foi, então, estabelecido.

  15. Immune thrombocytopenic purpura: A rare side effect in a patient treated with Imiquimod for lentigo maligna

    Directory of Open Access Journals (Sweden)

    E.A. Whatling

    2017-09-01

    Full Text Available Topical Imiquimod is increasingly used in the treatment of lentigo maligna (LM for patients not suitable or willing for surgery. It acts as an immune response modifier and is recommended for use with caution in patients with autoimmune disorders. A review of the literature did not reveal any reported cases of Idiopathic Thrombocytopenic Purpura (ITP with the use of Imiquimod so far. We report a case of a 55-year-old woman with a history of Addison's and Graves' disease who had been diagnosed with lentigo maligna on the right nasal ala. Within two days of commencing of topical Imiquimod treatment, she was admitted to the hospital with extensive cutaneous and mucosal bruising and treated as acute Idiopathic Throbocytopenic Purpura. Deranged platelets were reversed promptly with treatment and Imiquimod discontinued. We demonstrate that Idiopathic Throbocytopenic Purpura is a potential life-threatening side effect of Imiquimod treatment and patients who have autoimmune disorders are at increased risk of developing this side effect. We recommend that Imiquimod is contraindicated in patients with autoimmune disease. Here we describe the clinical presentation and review the relevant literature on Imiquimod treatment for lentigo maligna and its potential side effects.

  16. Determinantes celulares, plasmáticos y genéticos de riesgo de trombosis y hemorragia en pacientes con neoplasias mieloproliferativas crónicas filadelfia negativo

    OpenAIRE

    Moreno Belmonte, María José

    2010-01-01

    Las Neoplasias Mieloproliferativas Crónicas Filadelfia negativo clásicas comprenden la trombocitemia esencial, la policitemia vera y la mielofibrosis primaria y se caracterizan por la expansión clonal de la célula madre pluripotente, produciendo como resultado una hipercelularidad medular de predominio de una línea específica; la trombosis y el sangrado son parte de la historia natural de este grupo de enfermedades, constituyendo sus principales causas de morbimortalidad. Trabajos recientes h...

  17. Caracterización de pacientes con lesiones pigmentarias de piel con riesgo de transformación maligna

    Directory of Open Access Journals (Sweden)

    María Elena Izquierdo Izquierdo

    2015-06-01

    Full Text Available Fundamento: el melanoma es el más terrible y mortífero de los cánceres de piel. Se origina frecuentemente a partir de un nevo melanocítico con riesgo de transformación maligna. Estas lesiones pigmentadas se diagnostican cada vez más en edades tan tempranas como la adolescencia. Objetivo: caracterizar los pacientes en edades pediátricas con signos de lesiones pigmentarias de la piel con riesgo de transformación maligna. Métodos: se realizó un estudio prospectivo de corte transversal en un grupo de 50 pacientes en edades entre 5 y 19 años, que asistieron a la consulta de dermatología del Hospital Pediátrico de Centro Habana en el año 2010, con signos de lesiones pigmentarias de la piel con riesgo de transformación maligna. Se aplicó un instrumento de recogida de datos, con previo consentimiento informado. Se utilizó la estadística descriptiva para el procesamiento de los datos. Resultados: en la población de estudio predominó la adolescencia temprana, el grupo de riesgo con daño actínico crónico y el fototipo III. Estuvo presente el antecedente familiar de cáncer de piel no-melanoma. La lesión más frecuente fue la de nevo melanocítico displásico. Además, se reportó un caso de carcinoma basal en paciente de fototipo II, perteneciente al grupo de riesgo de xeroderma pigmentoso. Conclusiones: se evidenció la transformación maligna de lesiones pigmentarias en piel de pacientes de grupos de riesgo.

  18. Papel da criocirurgia no tratamento das neoplasias cutâneas do segmento cabeça e pescoço: análise de 1900 casos

    Directory of Open Access Journals (Sweden)

    Antonio Azoubel Antunes

    Full Text Available OBJETIVO: Demonstrar a experiência dos autores na utilização da criocirurgia como tratamento de lesões benignas e malignas da pele e mucosa no segmento cabeça e pescoço. MÉTODO: Os autores realizam um estudo retrospectivo multicêntrico de 1900 casos de pacientes portadores de neoplasias benignas e malignas da cabeça e do pescoço, atendidos e tratados no Centro de Oncologia do Hospital Universitário Oswaldo Cruz (CEON/HUOC/UPE, Hospital de Câncer de Pernambuco (HCP e clínica privada, no período de abril de 1977 a abril de 2002 (25 anos. Comparam, ainda, os dados obtidos com a revisão bibliográfica realizada, bem como sua experiência pessoal na utilização de tal modalidade terapêutica. RESULTADOS: Do total de pacientes, 57,9% eram do sexo masculino e a quinta e sexta décadas de vida foram as mais frequentemente acometidas (58,9%. O Carcinoma basocelular foi o tipo histológico predominante (63,1% - 1200 casos, seguido dos hemangiomas (14,2% - 270 casos. O tempo médio de exposição das lesões ao nitrogênio líquido foi de 15 e 35 segundos, e o tempo médio de cicatrização de 14 e 21 dias para as lesões benignas e malignas respectivamente. CONCLUSÕES: A indicação da criocirurgia deve obedecer alguns critérios de avaliação como o aspecto macroscópico e tamanho da lesão, tipo histológico, localização, idade e perfil social de cada paciente. Quando indicada e executada corretamente, oferece idênticos índices de cura aos outros métodos terapêuticos convencionais.

  19. Hipertermia maligna

    Directory of Open Access Journals (Sweden)

    Carlos Vilaplana Santaló

    2002-08-01

    Full Text Available La hipertermia maligna es un desorden hipermetabólico de los músculos esqueléticos, caracterizado por hipercalcemia intracelular y consumo rápido de adenosín trifosfato; esta condición se desencadena por la exposición a 1 o más agentes anestésicos precipitantes incluidos halotano, enflurano, isoflurano, desflurano, sevoflurano y el succinilcolina. Los síntomas de esta afección pueden presentarse en el quirófano o en la Unidad de Cuidados Posanestésicos y se caracteriza por aparición súbita de taquicardia, taquipnea, hipertensión, hipercapnia, hipertermia, acidosis y rigidez musculoesquelética. El dantroleno atenúa la elevación del calcio intracelular y puede ser administrado de forma profiláctica o inmediatamente que se sospeche el diagnóstico. Con el objetivo de conocer las bases fisiopatológicas de este síndrome y las pautas de tratamiento más empleadas se realizó una exhaustiva revisión bibliográficaMalignant hyperthermia is a hypermetabolic disorder of the skeletal muscles, characterized by intracellular hypercalcemia and rapid consumption of adenosine triphosphate. This condition appears as a result of the exposure to 1 or more precipitating anesthetic agents, including halothane, enflurane, isoflurane, desflurane, sevoflurane and succinylcholine. The symptoms of this affection may be present in the operating room or in the Unit of Postanesthetic Care and it is characterized by the sudden appearance of thachycardia, tachypnea, hypertensiion, hypercapnia, hyperthermia, acidosis and muscoloskeletal rigidity. Dantrolene attenuates the elevation of intracellular calcium and may be prophylactically administered or as soon as the diagnosis is suspected. In order to know the physiopathological basis of this syndrome and the most used treatment patterns, an exhaustive bibliographic review was made

  20. Caracterización de pacientes con neoplasias primarias del segmento hepatobiliopancreático

    Directory of Open Access Journals (Sweden)

    Danilo Romaguera Barroso

    2015-02-01

    Full Text Available Se realizó un estudio observacional, descriptivo y longitudinal de 60 pacientes con cáncer primario del segmento hepatobiliopancreático, operados y egresados vivos del Servicio de Cirugía General del Hospital Provincial Docente Clinicoquirúrgico "Saturnino Lora Torres" de Santiago de Cuba, desde el 2005 hasta el 2011, con vistas a caracterizarles según variables seleccionadas. Entre las localizaciones más frecuentes figuraron: páncreas, hígado, vesícula y vías biliares extrahepáticas, en pacientes de la sexta década de la vida del sexo masculino; aunque el tumor de vesícula biliar prevaleció en las féminas. La estadificación clínica de la mayoría correspondió a las etapas más avanzadas, limitada al tratamiento quirúrgico paliativo. Los pacientes con factores de riesgo deben ser dispensarizados en las áreas de atención primaria de salud para que acudan al nivel secundario en etapas iniciales de la enfermedad, y puedan recibir el tratamiento quirúrgico con intención curativa, lo cual mejora su pronóstico y calidad de vida

  1. Uso tópico do inteferon alfa-2b para neoplasia escamosa da superficie ocular em um caso de paciente com xeroderma pigmentoso

    Directory of Open Access Journals (Sweden)

    Nayara Queiroz Cardoso Pinto

    Full Text Available Resumo Relato de um caso clínico de Xeroderma Pigmentoso com carcinoma espinocelular de conjuntiva bilateral que apresentou regressão importante das dimensões tumorais com o uso de Interferon alfa-2b tópico. Relato de caso: Paciente feminina com Xeroderma Pigmentoso em estágio avançado, com ausência de pele sadia, tendo sido submetida a cerca de 60 exéreses de lesões de pele malignas. A paciente compareceu com tumoração conjuntival em ambos os olhos, correspondendo a carcinoma espinocelular de conjuntiva e neoplasia intraepitelial de conjuntiva em olho esquerdo. Devido as dificuldades cirúrgicas, alta taxa de recidiva e elevada probabilidade de formação de simbléfaro foi-se iniciado terapêutica com Interferon alfa-2beta 1.000.000 unidades tópico, obtendo-se bons resultados com importante regressão do tamanho da lesão e resolução dos sintomas. Conclusão: O uso tópico de interferon alfa-2beta em neoplasia escamosa de conjuntiva, mostrou-se uma boa opção terapêutica em situações de elevado risco cirúrgico e de complicações pós operatórias.

  2. Lentigo maligna - anatomic location as a potential risk factor for recurrences after non-surgical treatment

    NARCIS (Netherlands)

    K. Greveling (Karin); van der Klok, T. (Th.); M.B.A. van Doorn (Martijn); V. Noordhoek Hegt (Vincent); E.P. Prens (Errol)

    2016-01-01

    textabstractBackground: A higher incidence of lentigo maligna (LM) recurrences on the nose was previously observed in our cohort after non-surgical treatment. Objectives: To determine histological parameters that might be related to the previously observed higher incidence of LM recurrences on the

  3. Neoplasia no sítio da colostomia: relato de três casos e revisão da literatura

    Directory of Open Access Journals (Sweden)

    Valdemir José Alegre Salles

    2006-03-01

    Full Text Available Carcinomas raramente ocorrem no sitio da colostomia. O risco para o desenvolvimento de neoplasia maligna é semelhante a qualquer outro segmento colônico, porém se a ressecção inicial foi devida a câncer, há um significativo aumento na incidência de tumor metacrônico quando comparado à população em geral. A incidência do carcinoma metacrônico colônico é geralmente de 3 a 5%. A recorrência do tumor primário, quando associada à ostomia, pode se manifestar com sangramento ou obstrução. Relatamos três doentes com tumor no sitio da colostomia, sua manifestação clínica e a conduta terapêutica adotada.Carcinomas rarely occur at the site of a colostomy. Colostomies are risk for malignancy, just as in any other portion of the colon. If the initial resection was for cancer, then the risk of metachronous colon adenocarcinoma is significantly higher than for the general population. Metachronous colorectal carcinoma occurs from 0.1 to 3.6 percent of patients who undergo surgery for colorectal carcinoma and the recurrence of the primary bowel malignancy that necessitated the stoma may present with signs of bleeding or obstruction. We report three cases of this rare neoplasia occurring at the site of a colostomy, and we review the literature.

  4. Panorama epidemiológico de la mortalidad por cáncer en el Instituto Mexicano del Seguro Social: 1991-1995

    Directory of Open Access Journals (Sweden)

    SALMERÓN-CASTRO JORGE

    1997-01-01

    Full Text Available Objetivo. Describir el comportamiento de la mortalidad global por cáncer, así como la mortalidad específica para las principales neoplasias malignas en población adulta derechohabiente (DH del Instituto Mexicano del Seguro Social (IMSS. Material y métodos. A partir de los registros oficiales de defunción y de la información sobre la población para los años 1991-1995, se estimaron las tasas anuales de mortalidad global y específica para las 10 principales neoplasias malignas por sexo, en mayores de 20 años. Asimismo, se estimaron las tendencias nacionales y estatales para las principales neoplasias malignas para cada sexo por medio de regresión de Poisson. Se calcularon las diferencias de tasas de mortalidad específica para las dos principales neoplasias por sexo restando las tasas estatales a su respectiva tasa nacional en 1995. Resultados. La mortalidad global por cáncer en los hombres se incrementó de 76.2 en 1991, a 94.8 por 100 000 DH en 1995; entre las mujeres, ésta se incrementó de 85.6 a 105.8 por 100 000 DH, representando un incremento de 24.4 y de 24% en hombres y mujeres, respectivamente, durante el periodo de estudio. Entre los hombres las neoplasias de riñón, leucemia, páncreas, próstata y pulmón; y entre mujeres las de colon, mama, páncreas, leucemias e hígado, mostraron los incrementos más significativos. Conclusiones. En el IMSS es impostergable la conformación de un registro poblacional de cáncer que permita una mejor vigilancia epidemiológica de las neoplasias y una evaluación permanente del impacto de programas específicos para la prevención y control de este padecimiento en las instituciones.

  5. ¿CÓMO PUEDO MODIFICAR MI RIESGO A DESARROLLAR CÁNCER, CUANDO SOY PORTADOR DE UNA MUTACIÓN?

    Directory of Open Access Journals (Sweden)

    Dra. Yenni Rodríguez, MD

    2017-07-01

    Las estrategias para modificar el riesgo variarán con el conocimiento de la epidemiología, la etiología y los mecanismos moleculares específicos para cada cáncer individual. Los síndromes hereditarios de cáncer facilitarán este estudio ya que a medida que se disponga de más información sobre la genómica humana, será posible una comprensión clara de los mecanismos moleculares subyacentes de estas enfermedades y posiblemente resulten en estrategias eficaces para su control. Desafortunadamente, a pesar del amplio conocimiento disponible sobre los factores de riesgo para muchas de estas neoplasias malignas, hemos sido incapaces de influir en cambios efectivos en el estilo de vida que podrían reducir sustancialmente el riesgo de estas neoplasias malignas en nuestra población.

  6. Coexistence of prostate neoplasia in patients undergoing radical cystoprostatectomy due to vesical neoplasia

    Directory of Open Access Journals (Sweden)

    Frederico R. Romero

    2004-08-01

    Full Text Available OBJECTIVE: To assess the incidence of bladder carcinoma infiltrating the prostate and prostate adenocarcinoma in patients undergoing radical cystoprostatectomy due to bladder cancer, as well as to assess if the characteristics of the bladder neoplasia influence the prostatic involvement by this neoplasia. MATERIALS AND METHODS: We retrospectively assessed 60 male patients, who underwent radical cystoprostatectomy between July 1997 and December 2003. Mean age was 66.7 years (40 and 93 years. The product of radical cystoprostatectomies was checked for involvement of urethra and prostate parenchyma by the primary neoplasia, and for the presence of associated prostate adenocarcinoma. Bladder neoplasia characteristics, such as localization, size, multifocality, association with in situ carcinoma and histological grade, were studied in order to assess the possibility of using such characteristics as predictive factors of prostate infiltration by bladder urothelial carcinoma. RESULTS: We observed the presence of 20% of patients with bladder carcinoma infiltrating the prostatic urethra, 23.3% of patients with infiltration of the prostate parenchyma and 28.3% of patients with associate prostate adenocarcinoma, resulting in a total of 55% of patients with prostatic involvement (infiltrative bladder carcinoma and/or adenocarcinoma. We also observed a statistically significant correlation between tumor location in the trigone, the presence of in situ carcinoma and the histological grade of the bladder tumor with prostatic infiltration by the vesical neoplasia. CONCLUSION: The coexistence of prostatic neoplasia in patients operated for bladder neoplasia was frequent in our sample (55%. We observed that the prostatic infiltration by bladder tumors occurs more frequently with tumors located in the trigone, with associated in situ carcinoma and with high histological grade. There was no correlation between neoplastic infiltration of prostate and multifocality

  7. Anestesia para cirurgia ortopédica em criança com susceptibilidade à hipertermia maligna: relato de caso Anestesia para cirugía ortopédica en niño con susceptibilidad a la hipertermia maligna: relato de caso Anesthesia for orthopedic surgery in a child susceptible to malignant hyperthermia: case report

    Directory of Open Access Journals (Sweden)

    Renato Santiago Gomez

    2003-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Hipertermia maligna é uma miopatia autossômica dominante desencadeada por anestésicos inalatórios e bloqueadores neuromusculares, como halotano e succinilcolina, causando aumento da temperatura que pode ser fatal sem o tratamento imediato. O objetivo deste relato é descrever a conduta anestésica em uma criança susceptível à hipertermia maligna que foi submetida a procedimento cirúrgico ortopédico. RELATO DO CASO: Paciente do sexo feminino, com 3 anos, portadora de luxação congênita do quadril e susceptibilidade à hipertermia maligna, conforme história de anestesia anterior, foi submetida à correção cirúrgica ortopédica sob anestesia geral, com propofol e fentanil, associada à anestesia peridural lombar. A temperatura da paciente foi monitorizada continuamente durante a cirurgia e no período pós-operatório. A paciente apresentou recuperação pós-operatória sem intercorrências e recebeu alta hospitalar após cinco dias. CONCLUSÕES: A combinação de anestesia regional e venosa para o procedimento cirúrgico proposto em paciente com susceptibilidade à hipertermia maligna permitiu a condução anestésica com segurança.JUSTIFICATIVA Y OBJETIVOS: Hipertermia maligna es una miopatia autosómica dominante desencadenada por anestésicos inhalatorios y bloqueadores neuromusculares, como halotano y succinilcolina, causando aumento de la temperatura que puede ser fatal sin el tratamiento inmediato. El objetivo de este relato es describir la conducta anestésica en un niño susceptible a la hipertermia maligna que fue sometida a procedimiento quirúrgico ortopédico. RELATO DEL CASO: Niño, del sexo femenino, con 3 años, portadora de luxación congénita del cuadril (anca y susceptibilidad a la hipertermia maligna, conforme historia de anestesia anterior, fue sometida a la corrección quirúrgica ortopédica bajo anestesia general, con propofol y fentanil, asociada a anestesia peridural lumbar. La

  8. O papel da ecoendoscopia no diagnóstico das neoplasias císticas primárias do pâncreas Usefulness of echoendoscopy in the diagnosis of primary cystic neoplasms of the pancreas

    Directory of Open Access Journals (Sweden)

    Simone Guaraldi

    2005-12-01

    Full Text Available O diagnóstico das lesões císticas pancreáticas pelos métodos de imagem, especialmente as de pequeno tamanho, é cada vez mais freqüente. Em alguns casos, ele representa um dilema em relação à terapêutica, podendo ser pseudocistos inflamatórios, neoplasias primárias ou secundárias. Para a decisão terapêutica, é necessário definir se a neoplasia é benigna, maligna ou potencialmente maligna. Hoje, a ecoendoscopia é considerada o exame padrão-ouro para a investigação do pâncreas, fornecendo dados sobre a morfologia destas lesões e possibilitando, por meio da punção guiada em tempo real, a colheita de material para avaliação citológica e dos marcadores tumorais. Este procedimento é considerado seguro e eficiente e apresenta taxas de sensibilidade e especificidade altas e de morbidade e de complicações baixas. No diagnóstico das lesões mucinosas do pâncreas, os fatores preditivos mais significativos para o diagnóstico diferencial são a presença de septos, os nódulos murais e as alterações parenquimatosas, para o qual as taxas de sensibilidade, especificidade e grau de exatidão são, respectivamente, 94%, 85% e 88%. Os autores têm por objetivo revisar as principais neoplasias císticas primárias do pâncreas, enfatizando a aplicação da ecoendoscopia no diagnóstico definitivo dessas neoplasias.Pancreatic cystic lesions, particularly small lesions, are more easily diagnosed nowadays with the use of imaging methods. In some cases, the diagnosis represents a challenge to establish the treatment, as it can range from inflammatory pseudocysts to primary or metastatic cystic neoplasms. In order to choose the treatment, it is necessary to determine if the lesion is benign, borderline, or malignant. Currently, echoendoscopy is considered the gold standard procedure for pancreatic evaluation as it clearly shows the morphology of the lesion, and also allows the acquisition of pancreatic material for cytological and

  9. Valor diagnóstico del pepsinógeno i/ii como biomarcador de lesiones pre-malignas y malignas gástricas: revisión sistemática

    OpenAIRE

    Hidalgo Mora, Viviana Marcela; Whang, Joon Kyung

    2016-01-01

    Antecedentes: El cáncer gástrico se diagnostica tardíamente. Sólo en países como Corea y Japón existen políticas de tamizaje, que se justificarían en cualquier país con alta prevalencia de cáncer gástrico como Colombia o Chile. El análisis del pepsinógeno sérico se ha propuesto para el diagnóstico de lesiones premalignas y malignas gástricas, por lo cual se pretende revisar sistemáticamente en la literatura el valor diagnóstico del cociente pepsinógeno I/II como marcador de lesiones premalign...

  10. Sarcoma de estroma prostático gigante

    Directory of Open Access Journals (Sweden)

    Jose Luis González González

    Full Text Available Los tumores de próstata representan la neoplasia maligna más frecuente en el varón. Mientras que las lesiones epiteliales son frecuentes, las neoplasias de origen mesenquimal representan entre 1 y 2 % de las neoplasias malignas prostáticas. Son poco conocidas, sobre todo las de origen estromal. Se presenta el caso de un varón de 77 años de edad, con un sarcoma del estroma prostático al que se le realiza una exéresis parcial. El tumor ocupa prácticamente la totalidad de la cavidad pélvico-abdominal, con un diámetro de 35 cm y un peso de 3 800 g. Histológicamente se concluyó, como sarcoma prostático aunque en el transoperatorio no se encontró un nexo evidente con este órgano. El comportamiento clínico de estos tumores, basado en los escasos casos descritos en la literatura, es prácticamente desconocido y su diagnóstico preoperatorio difícil. Este paciente se presentó con pérdida de peso, sin dolor, hematuria, ni síntomas obstructivos.

  11. Risk of metachronous neoplasia on surveillance colonoscopy in young patients with colorectal neoplasia.

    Science.gov (United States)

    Kim, Hyun Gun; Cho, Young-Seok; Cha, Jae Myung; Shin, Jeong Eun; Kim, Kyeong Ok; Yang, Hyo-Joon; Koo, Hoon Sup; Joo, Young-Eun; Boo, Sun-Jin

    2018-03-01

    Few prior reports exist that address the appropriate colonoscopy surveillance interval for individuals  .1). In the baseline low-risk adenoma group (n = 1869), the 5-year risk of metachronous advanced neoplasia was 4.9% in the younger patients on screening colonoscopy and 5.1% in the older patients (P > .1). Similarly, in the baseline no neoplasia group (n = 7013), the 5-year risk of metachronous advanced neoplasia was 4.1% in the younger patients on screening colonoscopy and 5.6% in the older patients (P > .1). Considering the similar risk of metachronous advanced neoplasia in younger and older individuals, we suggest a 3-year surveillance interval for high-risk adenoma and a 5-year surveillance interval for low-risk adenoma in young individuals without a strong family history. Copyright © 2018 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.

  12. Elecciones primarias en España. 1993-2015

    OpenAIRE

    Sanz Díaz, Benito

    2015-01-01

    “Elecciones primarias en España. 1993-2015 ” analiza la intro¬ducción y desarrollo de las elecciones primarias de los partidos políti¬cos en España, y como una forma de participación típica de la política de los EE.UU., va consiguiendo arraigar en los partidos españoles. Será el PSOE el primero que implante el sistema de primarias (Con¬ferencia Política del PSPV en 1993); después en las elecciones pri¬marias para elegir candidato a la Presidencia del Gobierno de España (Almunia-Borrell), por ...

  13. Comentario al margen del artículo estenosis malignas del estómago

    OpenAIRE

    Gaitán Yanguas, Mario

    2012-01-01

    Leyendo la magnífica contribución que con el título anotado publicaron los doctores Jácome, Gutierrez, Parra, Forero y Medina en la página 214 del volumen 22 de la Revista de la Facultad de Medicina, encontré que dicen los autores que "entre los 301 casos de estenosis malignas del estómago observados en el Instituto Nacional de Cancerología no se encuentra ningún caso" de sarcoma gástrico, y que todos corresponden a carcinomas (escamosos ó glandulares). Sin embargo, existen en los archivos...

  14. Inflammatory Bowel Disease and Cervical Neoplasia

    DEFF Research Database (Denmark)

    Rungoe, Christine; Simonsen, Jacob; Riis, Lene

    2015-01-01

    BACKGROUND & AIMS: We examined the risk of cervical neoplasia (dysplasia or cancer) in women with ulcerative colitis (UC) or Crohn's disease (CD). We also calculated the reverse, the risk for diagnosis with cervical neoplasia before development of inflammatory bowel disease (IBD). METHODS: We...... established a national cohort of women diagnosed with UC (n = 18,691) or CD (n = 8717) between 1979 and 2011 and a control cohort of individually matched women from the general population (controls, n = 1,508,334). Incidence rate ratios (IRRs) of screening activity and diagnosis of cervical neoplasia in women...... with IBD were assessed by Cox proportional hazards regression analysis. Odds ratios (ORs) of cervical neoplasia before diagnosis of IBD were calculated by using conditional logistic regression. RESULTS: Women with CD underwent cervical cancer screening as often as women in the general population (IRR, 0...

  15. Biopsy study of salivary gland tumors

    OpenAIRE

    Rubio Pampín, Maria Magdalena; Hernández Melgarejo, Yasel; Sánchez Camacho, Luís Manuel; Martínez Larrarte, José Pedro

    2015-01-01

    Las neoplasias malignas y benignas de glándulas salivales pueden encontrarse en las glándulas salivales mayores (parótidas, submandibular, sublingual), así como en las innumerables glándulas salivares menores distribuidas por toda la mucosa de la cavidad bucal. Estas neoplasias dan lugar a una amplia variedad de tumores malignos y benignos. Entre el 65 y el 85 % se originan en la parótida y aproximadamente un 15 % son malignos. Nuestra investigación incluyó todos los casos con estudio biópsic...

  16. Fractal analysis of cervical intraepithelial neoplasia.

    Directory of Open Access Journals (Sweden)

    Markus Fabrizii

    Full Text Available INTRODUCTION: Cervical intraepithelial neoplasias (CIN represent precursor lesions of cervical cancer. These neoplastic lesions are traditionally subdivided into three categories CIN 1, CIN 2, and CIN 3, using microscopical criteria. The relation between grades of cervical intraepithelial neoplasia (CIN and its fractal dimension was investigated to establish a basis for an objective diagnosis using the method proposed. METHODS: Classical evaluation of the tissue samples was performed by an experienced gynecologic pathologist. Tissue samples were scanned and saved as digital images using Aperio scanner and software. After image segmentation the box counting method as well as multifractal methods were applied to determine the relation between fractal dimension and grades of CIN. A total of 46 images were used to compare the pathologist's neoplasia grades with the predicted groups obtained by fractal methods. RESULTS: Significant or highly significant differences between all grades of CIN could be found. The confusion matrix, comparing between pathologist's grading and predicted group by fractal methods showed a match of 87.1%. Multifractal spectra were able to differentiate between normal epithelium and low grade as well as high grade neoplasia. CONCLUSION: Fractal dimension can be considered to be an objective parameter to grade cervical intraepithelial neoplasia.

  17. Conexión entre inmunodeficiencia primaria y autoinmunidad

    OpenAIRE

    Lahera Sánchez, Tania

    2010-01-01

    Inmunodeficiencia y autoinmunidad constituyen 2 polos de la respuesta inmunitaria que pueden interrelacionarse con cierta frecuencia. En este artículo se exponen los síndromes autoinmunes que son causados por inmunodeficiencias primarias. También se describen otras inmunodeficiencias primarias como la inmunodeficiencia variable común, el síndrome de hiper Ig M, la deficiencia selectiva de Ig A, la hipogammaglobulinemia ligada al cromosoma X, el síndrome de Di George, la enfermedad granulomato...

  18. Detection of colorectal neoplasia

    DEFF Research Database (Denmark)

    Wilhelmsen, Michael; Christensen, Ib J; Rasmussen, Louise

    2017-01-01

    Serological biomarkers may be an option for early detection of colorectal cancer (CRC). The present study assessed eight cancer-associated protein biomarkers in plasma from subjects undergoing first time ever colonoscopy due to symptoms attributable to colorectal neoplasia. Plasma AFP, CA19-9, CEA...... value was 18% and the negative predictive value was 97%. Combinations of serological protein biomarkers provided a significant identification of subjects with high risk of the presence of colorectal neoplasia. The present set of biomarkers could become important adjunct in early detection of CRC....

  19. RASTREAMENTO MAMOGRÁFICO: DETECÇÃO DE LESÕES NEOPLÁSICAS MALIGNAS EM MULHERES DE SANTA CATARINA E DO BRASIL

    Directory of Open Access Journals (Sweden)

    Luciana Martins da Rosa

    2016-01-01

    Full Text Available El objetivo fue analizar las tasas de incidencia de lesión neoplásica maligna según tipo de detección y distribución proporcional de mamografías en mujeres de 40 a 69 años del Estado de Santa Catarina y de Brasil. Se trata de un estudio observacional descriptivo fundamentado en datos del Departamento de Tecnología de la Información del Sistema Único de Salud entre 2009 y 2012 y del Instituto Brasileño de Geografía y Estadística. En Brasil y en Santa Catarina, la mayor cobertura de la mamografía en mujeres de 45 a 49 años fue de 22,2% y 23,1% respectivamente. La mayor distribución proporcional fue de 89,2% en las brasileñas de 40 a 44 años y de 50 a 54 años en Santa Catarina. Las tasas de incidencia de lesión neoplásica maligna de mama diagnosticada por imagen se elevaron en el Brasil y Santa Catarina. En 2012, en Brasil la mayor detección ocurrió por medio de la palpación y en Santa Catarina a través de imagen en 2012. Se concluye que el cribado mamográfico está por debajo del nivel recomendado. Mayores distribuciones proporcionales de mamografías permitieron mayor número de diagnósticos de lesiones neoplásicas malignas y finalmente, la realización de la mamografía a partir de los 40 años contribuyó para el diagnóstico de cáncer de mama entre la fase etaria de 40 a 49 años.

  20. A carga das neoplasias no Brasil: mortalidade e morbidade hospitalar entre 2002-2004 The burden of neoplasm in Brazil: mortality and hospital morbidity from 2002 to 2004

    Directory of Open Access Journals (Sweden)

    Antonio Fernando Boing

    2007-08-01

    Full Text Available OBJETIVO: Descrever a morbidade hospitalar e a mortalidade por neoplasias no Brasil e regiões segundo gênero. MÉTODOS: Os dados de óbitos foram obtidos junto ao Sistema de Informações sobre Mortalidade e os de morbidade hospitalar no Sistema de Informações Hospitalares. Os óbitos foram categorizados segundo as localizações primárias do tumor, selecionadas de acordo com a décima revisão da Classificação Internacional de Doenças. Os dados populacionais são oriundos das estimativas intercensitárias do IBGE. O período de análise foi o triênio 2002-2004, o mais recente com dados de mortalidade no Brasil. Optou-se por calcular a média desse período para conferir maior estabilidade às taxas. RESULTADOS: Entre 2002 e 2004 ocorreram 405.415 óbitos por neoplasias no Brasil. As maiores taxas de mortalidade foram identificadas nas regiões Sul e Sudeste. Entre os homens, o câncer de traquéia, brônquios e pulmões foi a neoplasia maligna que apresentou maior mortalidade e entre as mulher foi o câncer de mama. Este agravo e o câncer de colo uterino foram os que mais demandaram internações, e a leucemia apresentou o maior custo médio e custo total em internações. CONCLUSÕES: A carga das neoplasias é extremamente elevada no Brasil e medidas públicas de caráter populacional devem ser priorizadas para o efetivo controle da morbidade e da mortalidade por este agravo.OBJECTIVE: To describe mortality and the hospital morbidity by neoplasias in Brazil and regions according to gender. METHODS: Data of deaths were obtained from the Mortality Information System and of hospital morbidity from the Hospital Information System. Deaths were categorized according to primary tumor sites, selected in accordance with the tenth revision of the International Classification of Diseases. The population data were drawn from the inter census estimates of the IBGE (Brazilian Institute of Geography and Statistics. The period of analysis was the

  1. Zollinger-Ellison syndrome, acromegaly, and colorectal neoplasia

    NARCIS (Netherlands)

    Tobi, M; Cats, A; Maliakkal, BJ; Kinzie, JL; Maliakkal, R; Dullaart, RPF; Luk, GD

    Zollinger-Ellison syndrome (ZES) and acromegaly are two hypersecretory states in which colorectal neoplasia has been described, but the incidence in the former condition may not be increased. We describe four patients with colorectal neoplasia associated with the ZES and review other published

  2. Lobular neoplasia: frequency and association with other breast lesions

    Directory of Open Access Journals (Sweden)

    Gobbi Helenice

    2011-08-01

    Full Text Available Abstract Background Using new molecular biology techniques, recent studies have implicated a common evolutionary pathway between lobular neoplasia, lobular carcinomas, and columnar cell lesions. Our aims were to assess the frequency of lobular neoplasia in a series of breast biopsies that were performed and examined in the same institution and to analyze the association between subtypes of lobular neoplasia and benign and malignant breast lesions. Methods Cases were selected after reviewing archived pathological reports in the Breast Pathology Laboratory, School of Medicine of Federal University of Minas Gerais (1999-2008. Cases of lobular neoplasia were reviewed and classified as atypical lobular hyperplasia, ductal involvement by cells of atypical lobular hyperplasia, lobular carcinoma in situ, and pleomorphic lobular carcinoma in situ. Coexistence of lobular neoplasia with other breast lesions, including columnar cell lesions, invasive ductal carcinoma and invasive lobular carcinoma, was evaluated. The association between lobular neoplasia and breast lesions was analyzed by Fisher's exact test and chi-square test for linear trend. Results We analyzed 5650 breast specimens, selecting 135 breast specimens (2.4% that had a diagnosis of lobular neoplasia, corresponding to 106 patients. Hematoxylin and eosin-stained slides were available for 84 cases, 5 of which were excluded because they contained only "indeterminate" in situ lesions. Of the 79 remaining cases, columnar cell lesions were present in 78.5%, primarily with columnar cell changes without atypia (67.7%. Invasive carcinoma was present in 45.6% of cases of lobular neoplasia--a similar frequency (47.2% as invasive ductal carcinoma and invasive lobular carcinoma. We noted a significant linear trend (p in situ compared with atypical lobular hyperplasia. Invasive lobular carcinomas were associated with lobular carcinoma in situ in 33% of cases, compared with 2.8% of atypical lobular

  3. Risk Factors for Cervical Intraepithelial Neoplasia

    Directory of Open Access Journals (Sweden)

    Estrella de la Caridad Armenteros Espino

    2016-09-01

    Full Text Available Background: cervix cancer constitutes the second cause of death worldwide, with new diagnosis each year. Objective: to determine the risk factors of cervical intraepithelial neoplasia in the municipality of Cruces. Methods: it was developed an analytical research with case and control design from November 2013 to November 2014. The group of cases was formed of the 34 women with this diagnosis. There were selected 64 females from the same environment with the same age for the control group. The data obtained by surveys and clinical records reviews were presented in absolute numbers and percentages. It was used Chi-squared test and odd ratio. Results: 52 % of women with neoplasia were less than 25 years old. Significant differences were found which associate neoplasia with early sexual intercourse, sexually transmitted infections by Papilloma virus, Plane genital condyloma, and the use of oral contraceptive pills. Multiple sex partner was a frequent antecedent. Conclusion: risk factors associated to cervical intraepithelial neoplasia in the group of women studied in the Cruces municipality were early sexual intercourse, mainly before 15 years old, multiple sex partner, sexually communicated diseases and the use of oral contraceptive pills for more than 5 years.

  4. Pregnancy outcomes after chemotherapy for trophoblastic neoplasia.

    Science.gov (United States)

    Garcia, Mila Trementosa; Lin, Lawrence Hsu; Fushida, Koji; Francisco, Rossana Pulcineli Vieira; Zugaib, Marcelo

    2016-12-01

    The successful development of chemotherapy enabled a fertilitysparing treatment for patients with trophoblastic neoplasia. After disease remission, the outcome of a subsequent pregnancy becomes a great concern for these women. To analyze existing studies in the literature that describe the reproductive outcomes of patients with trophoblastic neoplasia treated with chemotherapy. Systematic review was performed searching for articles on Medline/ Pubmed, Lilacs and Cochrane Library databases, using the terms "gestational trophoblastic disease" and "pregnancy outcome". A total of 18 articles were included. No evidence of decreased fertility after chemotherapy for trophoblastic neoplasia was observed. The abortion rates in patients who conceived within 6 months after chemotherapy was higher compared to those who waited longer. Some studies showed increased rates of stillbirth and repeat hydatidiform moles. Only one work showed increased congenital abnormalities. The pregnancies conceived after chemotherapy for trophoblastic neoplasia should be followed with clinical surveillance due to higher rates of some pregnancy complications. However, studies in the literature provide reassuring data about reproductive outcomes of these patients.

  5. NEOPLASIA IN SNAKES AT ZOO ATLANTA DURING 1992-2012.

    Science.gov (United States)

    Page-Karjian, Annie; Hahne, Megan; Leach, Kate; Murphy, Hayley; Lock, Brad; Rivera, Samuel

    2017-06-01

    A retrospective study was conducted to review neoplasia of captive snakes in the Zoo Atlanta collection from 1992 to 2012. Of 255 snakes that underwent necropsy and histopathologic examination at Zoo Atlanta during the study period, 37 were observed with neoplasia at necropsy. In those 37 snakes, 42 neoplastic lesions of 18 primary cell types were diagnosed. Thirty-five of those neoplasms (83.3%) were malignant, and of those, 19 were of mesenchymal origin, whereas 14 were of epithelial origin. The median annual rate of neoplasia at necropsy was 12.5% (interquartile range = 2.8-19.5%) over the 21-yr study period. The mean estimated age at death for snakes with neoplasia was 13.2 yr (range, 1-24 yr). Investigating the incidence and clinical significance of neoplasia in captive snakes is vital for developing effective preventative and treatment regimes.

  6. Can the Ni classification of vessels predict neoplasia?

    DEFF Research Database (Denmark)

    Mehlum, Camilla Slot; Rosenberg, Tine; Dyrvig, Anne-Kirstine

    2018-01-01

    OBJECTIVES: The Ni classification of vascular change from 2011 is well documented for evaluating pharyngeal and laryngeal lesions, primarily focusing on cancer. In the planning of surgery it may be more relevant to differentiate neoplasia from non-neoplasia. We aimed to evaluate the ability...... of the Ni classification to predict laryngeal or hypopharyngeal neoplasia and to investigate if a changed cutoff value would support the recent European Laryngological Society (ELS) proposal of perpendicular vascular changes as indicative of neoplasia. DATA SOURCES: PubMed, Embase, Cochrane, and Scopus....... The pooled sensitivity and specificity of the Ni classification with two different cutoffs were calculated, and bubble and summary receiver operating characteristics plots were created. RESULTS: The combined sensitivity of five studies (n = 687) with Ni type IV-V defined as test-positive was 0.89 (95...

  7. Results of 52 cases with struma maligna treated with radio-iodine

    International Nuclear Information System (INIS)

    Grebe, S.F.; Huth, K.D.

    1982-01-01

    Results of 52 cases with struma maligna treated with radio-iodine. Between 1966 and 1977, 52 thyroid carcinoma patients received radio-iodine therapy. Their age ranged from 18 to 82 years. Out of 52 patients, 46 underwent surgery with 26 thyrodectomized subtotally and 20 totally so. No surgery was performed in 6 cases since this was refused in 2 cases and inoperable for clinical reasons in 4 cases. Radio-iodine treatment was performed 6 to 10 weeks after operation or 2 to 4 weeks after diagnosis. In 9 cases, additional irradiation therapy was performed on metastases (predominantly in skeleton) at total doses ranging between 2500-7500 R focal dose for palliative reasons. In terms of summary, the authors draw the conclusion that surgical ablation of thyroid tissue as total as possible combined with subsequent radio-iodine treatments till complete destruction of the iodine-storing tissue imposes as the optimum treatment of follicular and papillary thyroid carcinoma. (orig./MG) [de

  8. Hepatojejunostomia periférica: uma alternativa técnica no tratamento paliativo das neoplasias malignas do hilo hepático

    Directory of Open Access Journals (Sweden)

    Roberto Pelegrini Coral

    Full Text Available OBJETIVO: Relatar a experiência do nosso Serviço com a descompressão cirúrgica da árvore biliar através de uma hepatojejunostomia periférica. MÉTODO: Entre julho de 2000 a julho de 2005, 11 pacientes foram à laparotomia para ressecção de tumores do hilo hepático e, durante o trans-operatório, apresentavam lesões irressecáveis. Os dados analisados foram: idade, sexo, morbidade, mortalidade, dosagem de bilirrubinas séricas pré-operatórias e no 7ºdia de pós-operatório, prurido pré e pós-operatório e sobrevida. RESULTADOS: A idade média dos pacientes foi de 67 anos, seis eram mulheres e cinco eram homens. Icterícia estava presente em 100% dos casos e prurido em 80%. Seis pacientes tiveram o diagnóstico de neoplasia de vesícula biliar e cinco de colangiocarcinoma. Ocorreram três óbitos intra-hospitalares. A dosagem média no pré-operatório de bilirrubina total foi 19,33mg/dl e bilirrubina direta 16,81mg/dl e no pós-operatório 4,88mg/dl e 3,64mg/dl, respectivamente. Oito pacientes que receberam alta hospitalar tiveram sobrevida média de oito meses, evoluindo sem icterícia e prurido. CONCLUSÃO: A hepatojejunostomia periférica pode ser considerada uma boa opção como tratamento paliativo . Ela demonstrou ser segura, com sangramento mínimo, rápida execução e mortalidade aceitável, melhorando significativamente a icterícia, o prurido e fornecendo uma sobrevida satisfatória.

  9. Pregnancy outcomes after chemotherapy for trophoblastic neoplasia

    Directory of Open Access Journals (Sweden)

    MILA TREMENTOSA GARCIA

    Full Text Available SUMMARY Introduction The successful development of chemotherapy enabled a fertilitysparing treatment for patients with trophoblastic neoplasia. After disease remission, the outcome of a subsequent pregnancy becomes a great concern for these women. Objective To analyze existing studies in the literature that describe the reproductive outcomes of patients with trophoblastic neoplasia treated with chemotherapy. Method Systematic review was performed searching for articles on Medline/ Pubmed, Lilacs and Cochrane Library databases, using the terms “gestational trophoblastic disease” and “pregnancy outcome”. Results A total of 18 articles were included. No evidence of decreased fertility after chemotherapy for trophoblastic neoplasia was observed. The abortion rates in patients who conceived within 6 months after chemotherapy was higher compared to those who waited longer. Some studies showed increased rates of stillbirth and repeat hydatidiform moles. Only one work showed increased congenital abnormalities. Conclusion The pregnancies conceived after chemotherapy for trophoblastic neoplasia should be followed with clinical surveillance due to higher rates of some pregnancy complications. However, studies in the literature provide reassuring data about reproductive outcomes of these patients.

  10. Hemorragia intraventricular primaria

    OpenAIRE

    Pérez Nellar, Jesús; Roselló Silva, Héctor; Scherle Matamoros, Claudio; Hierro García, Daniel; Cutiño Maas, Yaineli; González González, Justo

    2006-01-01

    Se presentó el caso de una mujer de 21 años con hemorragia intraventricular primaria, causada por una malformación arterio-venosa. Se realizó estudio angiográfico cerebral y se diagnósticó una malformación vascular. Se embolizó la lesión y la paciente se recuperó sin secuelas neurológicas The case of a woman aged 21 with primary intraventricular haemorrhage caused by an arteriovenous malformation is presented. A cerebral angiographic study was carried out and a vascular malformation was di...

  11. Intrathoracic neoplasia: Epidemiology and etiology

    Energy Technology Data Exchange (ETDEWEB)

    Weller, R.E.

    1992-05-01

    Neoplasms of the thorax encompass those derived from the thoracic wall, trachea, mediastinum, lungs and pleura. They represent a wide variety of lesions including benign and malignant tumors arising from many tissues. The large surface area, 60 to 90 m{sup 2} in man, represented by the respiratory epithelium and associated thoracic structures are ideal targets for carcinogens carried by inspired air. The topic of discussion in this report is the epidemiology, etiology, and mechanisms of spontaneous intrathoracic neoplasia in animals and man. Much of what we know or suspect about thoracic neoplasia in animals has been extrapolated from experimentally-induced neoplasms.

  12. Surgical treatment of pancreatic endocrine tumors in multiple endocrine neoplasia type 1

    Directory of Open Access Journals (Sweden)

    Marcel Cerqueira Cesar Machado

    Full Text Available Surgical approaches to pancreatic endocrine tumors associated with multiple endocrine neoplasia type 1 may differ greatly from those applied to sporadic pancreatic endocrine tumors. Presurgical diagnosis of multiple endocrine neoplasia type 1 is therefore crucial to plan a proper intervention. Of note, hyperparathyroidism/multiple endocrine neoplasia type 1 should be surgically treated before pancreatic endocrine tumors/multiple endocrine neoplasia type 1 resection, apart from insulinoma. Non-functioning pancreatic endocrine tumors/multiple endocrine neoplasia type 1 >1 cm have a high risk of malignancy and should be treated by a pancreatic resection associated with lymphadenectomy. The vast majority of patients with gastrinoma/multiple endocrine neoplasia type 1 present with tumor lesions at the duodenum, so the surgery of choice is subtotal or total pancreatoduodenectomy followed by regional lymphadenectomy. The usual surgical treatment for insulinoma/multiple endocrine neoplasia type 1 is distal pancreatectomy up to the mesenteric vein with or without spleen preservation, associated with enucleation of tumor lesions in the pancreatic head. Surgical procedures for glucagonomas, somatostatinomas, and vipomas/ multiple endocrine neoplasia type 1 are similar to those applied to sporadic pancreatic endocrine tumors. Some of these surgical strategies for pancreatic endocrine tumors/multiple endocrine neoplasia type 1 still remain controversial as to their proper extension and timing. Furthermore, surgical resection of single hepatic metastasis secondary to pancreatic endocrine tumors/multiple endocrine neoplasia type 1 may be curative and even in multiple liver metastases surgical resection is possible. Hepatic trans-arterial chemo-embolization is usually associated with surgical resection. Liver transplantation may be needed for select cases. Finally, pre-surgical clinical and genetic diagnosis of multiple endocrine neoplasia type 1 syndrome and

  13. Primarias en la Comunitat Valenciana. 2014-2015. Partidos valencianos y primarias para la elección de candidato a la Presidencia de la Generalitat en la CV. Documentos de los partidos

    OpenAIRE

    Sanz Díaz, Benito

    2015-01-01

    A lo largo de 2014 y principios de 2015, casi todos los partidos políticos que se van a presentar a las elecciones de 2015 (locales, autonómicas y generales) van a realizar algún tipo de primarias para la selección de sus candidatos, a excepción del PP. Los partidos que celebran primarias abiertas en la Comunidad Valenciana -CV- son el PSPV - presenciales-, EUPV, Compromís y Podemos, estos tres admiten también voto por Internet y correo. Solo votaban en primarias los afiliados ...

  14. Epidemiology of basal cell carcinomas and squamous cell carcinomas in a Department of Dermatology: a 5 year review Epidemiologia dos carcinomas basocelulares e espinhocelulares em um Serviço de Dermatologia: revisão de 5 anos

    Directory of Open Access Journals (Sweden)

    Pedro Andrade

    2012-04-01

    Full Text Available BACKGROUND: Non-melanoma skin cancer, a common designation for both basal cell carcinomas and squamous cell carcinomas, is the most frequent malignant skin neoplasm. OBJECTIVE: Epidemiologic characterization of the population with Non-melanoma skin cancer. METHODS: Retrospective analysis of all patients diagnosed with Non-melanoma skin cancer based on histopathologic analysis of all incisional or excisional skin biopsies performed between 2004 and 2008 in a Department of Dermatology. RESULTS: A total of 3075 Non-melanoma skin cancers were identified, representing 88% of all malignant skin neoplasms (n=3493 diagnosed in the same period. Of those, 68,3% were basal cell carcinomas. Most Non-melanoma skin cancer patients were female and over 60 years old. Of all Non-melanoma skin cancer, 81,7% (n=1443 were located in sun-exposed skin, and represented 95,1% of malignant skin neoplasms in sun-exposed skin. Non-melanoma skin cancer was the most frequent malignant skin neoplasm in most topographic locations, except for abdomen and pelvis - over 95% of all malignant skin neoplasms in the face, neck and scalp were Non-melanoma skin cancer. Basal cell carcinomas were clearly predominant in all locations, except in upper and lower limbs, lower lip and genitals, where squamous cell carcinomas represented respectively 77,7%, 77,4%, 94,7% and 95,3% of the Non-melanoma skin cancers. CONCLUSION: Being the most common skin cancer, Non-melanoma skin cancer should be under constant surveillance, in order to monitor its epidemiologic dynamics, the efficiency of preventive measures and the adaptation of the healthcare resources.FUNDAMENTOS: O cancro cutâneo não-melanoma, designação conjunta para os carcinomas basocelulares e espinhocelulares, é o tipo de neoplasia cutânea maligna mais frequente. OBJETIVOS: Caracterização epidemiológica da população diagnosticada com cancro cutâneo não-melanoma. MÉTODOS: Foi realizada uma análise retrospectiva dos

  15. Las computadoras en la educación primaria: Un estudio piloto

    Directory of Open Access Journals (Sweden)

    Jesús Francisco Galaz Fontes

    1989-01-01

    Full Text Available De un grupo de cuarto año de primaria se seleccionó a diez estudiantes para tomar un pequeño curso de Logo con una maestra, también de primaria, que había sido previamente entrenada en dicho lenguaje de computación. Ambos grupos de sujetos resolvieron un pretest y un postest de aritmética. Los datos muestran que el grupo que recibió el entrenamiento Logo tuvo una mejor ejecución en el postest que el grupo control. Además, las opiniones de los estudiantes, padres de familia y maestra fueron, en general, positivas respecto a la experiencia de aprender a programar Logo, así como en relación al uso de las computadoras en la educación primaria. Se discute si el uso educativo de las computadoras en general. y del lenguaje Logo en particular, puede representar un medio para mejorar el desempeño académico a nivel primaria, sobre todo en zonas urbanas de la frontera norte de México, donde la cultura y las condiciones económicas hacen más viable esta alternativa educativa.

  16. Ultrathin endoscopy versus high-resolution endoscopy for diagnosing superficial gastric neoplasia.

    Science.gov (United States)

    Toyoizumi, Hirobumi; Kaise, Mitsuru; Arakawa, Hiroshi; Yonezawa, Jin; Yoshida, Yukinaga; Kato, Masayuki; Yoshimura, Noboru; Goda, Ken-ichi; Tajiri, Hisao

    2009-08-01

    Ultrathin endoscopy (UTE) is an acceptable and cost-effective alternative to EGD with the patient under sedation, although the diagnostic accuracy of UTE is not well established. To compare the diagnostic accuracy of UTE and high-resolution endoscopy (HRE) for superficial gastric neoplasia. Prospective comparative study. Academic center. Patients with or without superficial gastric neoplasia underwent peroral UTE and HRE, back-to-back in a random order while under standard sedation. The procedures were performed by 2 endoscopists who were blinded to the clinical information. The rate of missed lesions and misdiagnosis, sensitivity, and specificity for the diagnosis of gastric neoplasia when using pathology as the reference standard. In total, 126 lesions (41 superficial gastric neoplasias, 85 nonneoplastic lesions) were recorded in 57 enrolled patients. For the diagnosis of gastric neoplasia, the sensitivity of UTE (58.5%) was significantly (P = .021) lower than that of HRE (78%), and the specificity of UTE (91.8%) was significantly (P = .014) lower than that of HRE (100%). The rate of missed lesions and misdiagnosis of gastric neoplasias when using UTE (41.5%) was significantly (P > .001) higher than that of HRE (22.0%). The corresponding rate of neoplasias at the proximal portion (fornix and corpus) when using UTE (29%) was significantly (P = .002) higher than that of HRE (7.2%), although the rates of neoplasias at the distal portion (angulus and antrum) were comparable for UTE and HRE. Small sample numbers in an enriched population. The diagnostic accuracy of UTE is significantly lower than that of HRE for superficial gastric neoplasia, and this difference is particularly striking for neoplasias in the proximal stomach. For UTE to be used as an alternative modality, improvements in optical quality and the incorporation of additional procedures, including close-range observations and chromoendoscopy, are required to enhance visualization.

  17. Testicular neoplasia in undescended testes of cryptorchid boys-does surgical strategy have an impact on the risk of invasive testicular neoplasia?

    DEFF Research Database (Denmark)

    Cortes, Dina; Thorup, Jørgen Mogens; Petersen, Bodil Laub

    2004-01-01

    We investigated whether or not surgical strategy has an impact on the risk of invasive testicular neoplasia in cases of cryptorchidism. We made a database study of the incidence of testicular neoplasia at surgery for cryptorchidism in childhood, and evaluated if such abnormalities were found......, p placed...

  18. Feocromocitoma em bovinos de abate: relatos de casos Pheochromocytoma in slaughtered bovine: cases reports

    Directory of Open Access Journals (Sweden)

    W.L.A. Pereira

    2007-04-01

    Full Text Available Relatou-se a ocorrência de dois casos de tumor de medular da adrenal em bovino. O caso 1 foi representado por uma neoplasia de 6,0×4,5cm de tamanho e cor amarelo-acastanhada. O caso 2 constituiu-se de neoplasia maligna, com a lesão primária medindo 33,0×18,0cm e peso de 6,5kg. Metástases estavam presentes nos pulmões e nos linfonodos tráqueobronquiais, mediastínicos e esofagianos. A análise histológica das neoplasias permitiu o diagnóstico de feocromocitoma.Two cases of adrenal medular tumor in bovine are described. In case 1, yellow-brownish neoplasia of 6.0×4.5cm size was observed. Case 2, was constituted of a malignant neoplasia with the primary lesion measuring 33.0×18.0cm and weighing 6.5kg. Metastases were found in the lungs and in the tracheobronchial, mediastinic and oesophageal lymph nodes. Histopathological analysis confirmed the diagnosis of pheochromocytoma.

  19. Comparação dos métodos de imagem no diagnóstico dos tumores renais e calcificações nestas neoplasias Comparison of imaging methods for diagnosis of renal tumors and their calcifications

    Directory of Open Access Journals (Sweden)

    Sergio Marrone Ribeiro

    2004-12-01

    Full Text Available OBJETIVO: Tentar estabelecer uma metodologia no diagnóstico e conduta dos pacientes com massas renais sólidas e complexas, comparando os custos e benefícios dos diferentes métodos de diagnóstico por imagem. Procuramos avançar no diagnóstico diferencial entre lesões benignas e malignas, particularmente através da investigação das calcificações tumorais. MÉTODOS: Realizamos um estudo prospectivo em 31 pacientes portadores de massas renais sólidas ou complexas, todos eles submetidos à ultra-sonografia abdominal (US, ultra-sonografia doppler da massa renal (US Dop, tomografia computadorizada (TC e ressonância magnética (RM. RESULTADOS: Encontramos 28 pacientes com massas malignas e três com massas benignas. Entre os 28 pacientes com lesões malignas, 17 mostraram calcificações pela TC; 16 deles calcificações do tipo central e um calcificação do tipo curvilinear periférica pura (casca de ovo. A urografia excretora (UGE mostrou uma taxa de detecção para calcificações significantemente menor que a US e a TC. Massas benignas e malignas apareceram como descrito na literatura, com o US, TC e RM mostrando alta sensibilidade e especificidade no diagnóstico dos tumores renais. A exceção foi na US Dop, onde nós obtivemos menor sensibilidade para a caracterização de fluxo tumoral maligno. CONCLUSÕES: Foi surpreendente verificar que a TC revelou calcificações centrais em 51,6% dos pacientes desta série, todas elas em lesões malignas, quando a literatura refere uma freqüência de calcificações entre 8% e 22% dos carcinomas de células renais, em estudos utilizando radiografias simples do abdômen e UGE. Este achado é de grande importância quando consideramos que estas calcificações ocorrem particularmente em neoplasias malignas. Como resultado da comparação dos diferentes métodos de diagnóstico por imagem, nós propomos uma metodologia para adequada investigação dos tumores renais.BACKGROUND: To establish the

  20. Mitotic and apoptotic activity in colorectal neoplasia.

    Science.gov (United States)

    Kohoutova, Darina; Pejchal, Jaroslav; Bures, Jan

    2018-05-18

    Colorectal cancer (CRC) is third most commonly diagnosed cancer worldwide. The aim of the prospective study was to evaluate mitosis and apoptosis of epithelial cells at each stage of colorectal neoplasia. A total of 61 persons were enrolled into the study: 18 patients with non-advanced colorectal adenoma (non-a-A), 13 patients with advanced colorectal adenoma (a-A), 13 patients with CRC and 17 controls: individuals with normal findings on colonoscopy. Biopsy samples were taken from pathology (patients) and healthy mucosa (patients and healthy controls). Samples were formalin-fixed paraffin-embedded and stained with haematoxylin-eosin. Mitotic and apoptotic activity were evaluated in lower and upper part of the crypts and in the superficial compartment. Apoptotic activity was also assessed using detection of activated caspase-3. In controls, mitotic activity was present in lower part of crypts, accompanied with low apoptotic activity. Mitotic and apoptotic activity decreased (to almost zero) in upper part of crypts. In superficial compartment, increase in apoptotic activity was observed. Transformation of healthy mucosa into non-a-A was associated with significant increase of mitotic activity in lower and upper part of the crypts and with significant increase of apoptotic activity in all three compartments; p colorectal neoplasia were observed. Detection of activated caspase-3 confirmed the above findings in apoptotic activity. Significant dysregulation of mitosis and apoptosis during the progression of colorectal neoplasia, corresponding with histology, was confirmed. In patients with sporadic colorectal neoplasia, healthy mucosa does not display different mitotic and apoptotic activity compared to mucosa in healthy controls and therefore adequate endoscopic/surgical removal of colorectal neoplasia is sufficient.

  1. COMPUTED TOMOGRAPHIC EVALUATION OF CANINE PHARYNGEAL NEOPLASIA

    OpenAIRE

    Carozzi, Gregorio

    2016-01-01

    Computed tomography (CT) is commonly used to investigate head tumours in dogs, and is a fundamental part of the diagnostic work-up, for diagnosis, staging and planning therapy in neoplastic disease. Nasal diseases, either neoplastic or non-neoplastic diseases, oral neoplasia, brain disease, thyroid or carotid body neoplasia have been extensively studied. However little information are available for lesions of the pharyngeal area. In this thesis, cases of dogs affected by pharyngeal neoplas...

  2. Ocular Surface Squamous Neoplasia in Xeroderma Pigmentosum

    Directory of Open Access Journals (Sweden)

    Rajesh R Nayak

    2013-11-01

    Full Text Available Xeroderma pigmentosum (XP is a rare genetic disorder associated with multiple oculocutaneous and neurological manifestations. It occurs due to deficiency of the enzymes responsible for repairing ultraviolet radiation-induced DNA damage. Persistence of un-repaired DNA results in somatic mutations, leading to neoplasia of the skin and ocular surface. As this condition is rare, only isolated case reports of XP with ocular surface squamous neoplasia (OSSN are found in literature.

  3. Quantitative attenuation analysis for identification of early Barrett's neoplasia in volumetric laser endomicroscopy

    Science.gov (United States)

    Swager, Anne-Fre; Faber, Dirk J.; de Bruin, Daniel M.; Weusten, Bas L.; Meijer, Sybren L.; Bergman, Jacques J.; Curvers, Wouter L.; van Leeuwen, Ton G.

    2017-08-01

    Early neoplasia in Barrett's esophagus (BE) is difficult to detect. Volumetric laser endomicroscopy (VLE) incorporates optical coherence tomography, providing a circumferential scan of the esophageal wall layers. The attenuation coefficient (μVLE) quantifies decay of detected backscattered light versus depth, and could potentially improve BE neoplasia detection. The aim is to investigate feasibility of μVLE for identification of early BE neoplasia. In vivo and ex vivo VLE scans with histological correlation from BE patients ± neoplasia were used. Quantification by μVLE was performed manually on areas of interest (AoIs) to differentiate neoplasia from nondysplastic (ND)BE. From ex vivo VLE scans from 16 patients (13 with neoplasia), 68 AoIs were analyzed. Median μVLE values (mm-1) were 3.7 [2.1 to 4.4 interquartile range (IQR)] for NDBE and 4.0 (2.5 to 4.9 IQR) for neoplasia, not statistically different (p=0.82). Fourteen in vivo scans were used: nine from neoplastic and five from NDBE patients. Median μVLE values were 1.8 (1.5 to 2.6 IQR) for NDBE and 2.1 (1.9 to 2.6 IQR) for neoplasia, with no statistically significant difference (p=0.37). In conclusion, there was no significant difference in μVLE values in VLE scans from early neoplasia versus NDBE. Future studies with a larger sample size should explore other quantitative methods for detection of neoplasia during BE surveillance.

  4. Primary pulmonary neoplasia in the dog and cat

    International Nuclear Information System (INIS)

    Mehlhaff, C.J.; Mooney, S.

    1985-01-01

    This article covers the pertinent clinical, physical, and radiographic findings in dogs and cats with primary pulmonary neoplasia. Diagnostic and treatment recommendations are made. Although primary pulmonary neoplasia is rare in both the dog and cat, it appears to be diagnosed with increasing frequency. Early detection and surgical treatment of carefully selected cases can prolong a good quality of life

  5. Tumor de colisão de pele do pescoço

    Directory of Open Access Journals (Sweden)

    Helma Maria Chedid

    Full Text Available O tumor de colisão ou tumor misto é uma neoplasia maligna de pele, relacionada à exposição solar e com índices de incidência de até 1,5%. Apresenta comportamento clínico peculiar, em relação às demais neoplasias malignas de pele e com diagnóstico histológico, caracterizado pela colisão entre um carcinoma basocelular e um carcinoma epidermóide, ou seja, duas neoplasias com histologias distintas e interface nítida entre ambas. O caso relatado foi de paciente do sexo masculino, 73 anos, com duas lesões cervicais de crescimento progressivo nos últimos meses. O tratamento realizado foi cirúrgico, com exame histológico demonstrando a presença de carcinoma de células escamosas contíguo ao carcinoma de células basais. O acometimento preferencial ocorre em homens de pele clara, na quinta ou sexta décadas de vida. Sua localização mais comum é na cabeça e pescoço, principalmente na parte central da face. O carcinoma basoescamoso é diagnóstico diferencial, definido através de critérios histológicos distintos, uma vez que ambas neoplasias apresentam comportamento clínico semelhante. Os índices de recidiva local variam de 12% a 45%, enquanto que é baixo na recidiva regional, de aproximadamente 7,5%. Os principais fatores prognósticos são o gênero do paciente, margens cirúrgicas, infiltração perineural e status linfonodal. O tratamento de escolha é a ressecção, sendo a radioterapia indicada na sua adjuvância e lesões irressecáveis. A recidiva local é o principal fator limitante na sobrevida livre de doença que apresenta resultados pobres.

  6. Molecular diagnosis of multiple endocrine neoplasia type 2A ...

    African Journals Online (AJOL)

    Molecular diagnosis of multiple endocrine neoplasia type 2A. RJ Pegoraro, DJ Hacking, RH Buck, L Rom, PA Lanning, GMB Berger. Abstract. Objective. To identify by means of genetic analyses individuals who are at risk of developing medullary thyroid cancer that is a component of multiple endocrine neoplasia. Subjects.

  7. Tiempo y espacio en atención primaria de salud

    OpenAIRE

    Uribe Oyarbide, José María

    1994-01-01

    En este artículo se esbozan las líneas de repercusión que la reforma sanitaria provoca en la percepción y significación de las categorías tiempo y espacio. La Atención Primaria de Salud obliga a un aprendizaje tanto para trabajadores sanitarios como para usuarios de los criterios que definen y contextualizan la prestación de los servicios de salud. En ese contexto, los equipos de Atención Primaria introducen variaciones en su interrelación con instituciones como los hospitales y los ambulator...

  8. Tiempo y espacio en atención primaria de salud

    Directory of Open Access Journals (Sweden)

    JOSÉ Mª URIBE OYARBIDE

    1994-01-01

    Full Text Available En este artículo se esbozan las líneas de repercusión que la reforma sanitaria provoca en la percepción y significación de las categorías tiempo y espacio. La atención primaria de salud obliga a un aprendizaje tanto para los trabajadores sanitarios como para los usuarios de los criterios que definen y contextualizan la prestación de los servicios de salud. En este contexto, los equipos de atención primaria introducen variaciones en su interrelación con instituciones como los hospitales y los ambulatorios,

  9. La escritura creativa: Fomento de la lectura en el alumnado de Primaria. (La animación a la lectura y a la escritura en una clase de Primaria)

    OpenAIRE

    Villanueva Roa, Juan de Dios

    2017-01-01

    LA ESCRITURA CREATIVA: FOMENTO DE LA LECTURA EN EL ALUMNADO DE PRIMARIA. (La animación a la lectura y a la escritura en una clase de Primaria) Conferencia dictada por Juan de Dios Villanueva Roa Profesor Departamento de Didáctica de la Lengua y la Literatura Universidad de Granada RESUMEN En esta conferencia trataremos las inquietudes que pueden existir en la sociedad actual con respecto a la lectura y a la escritura, fundamentalmente en el alum...

  10. Condiciones de trabajo de los pediatras de Atención Primaria

    OpenAIRE

    Hernández Guillén, R.; Domínguez Aurrecoechea, B.; Sánchez Cordero, N.

    2014-01-01

    Introducción: en el sistema público de salud, la población debería ser el centro del sistema y el profesional sanitario su principal activo; garantizar que el encuentro asistencial se realice bajo unas condiciones de calidad es fundamental en la organización y diseño de los sistemas sanitarios. Conocer la realidad de los Equipos de Atención Primaria (EAP) y las condiciones de trabajo de los pediatras de Atención Primaria (PAP) resulta imprescindible para poder ofrecer una mejor asistencia a n...

  11. 1998. Primarias en España. Se inicia la era posfelipista. Almunia versus Borrell. 24 de abril de 1998

    OpenAIRE

    Sanz Díaz, Benito

    2015-01-01

    Primarias en España. Se inicia la era posfelipista. Almunia versus borrell. 24 de abril de 1998. Felipe González: “…no seré candidato a la Secretaría General”. Las elecciones primarias socialistas en el País Vasco. Nicolás Redondo Terreros/Rosa Díez. 14 de marzo de 1998. Almunia opta por las primarias. Almunia versus Borrell. 24 de abril 1998. Borrell se lanza a la piscina. El proceso. Cómo se organizaron las primeras elecciones primarias. La campaña electoral Almunia/Borrell. Sondeos sobre i...

  12. La informatización de la atención primaria de salud

    Directory of Open Access Journals (Sweden)

    Rodolfo J. Stusser Beltranena

    Full Text Available La informatización de la atención primaria de salud se percibe como un problema que se soluciona creando redes computarizadas entre los consultorios y policlínicos. El artículo brinda una visión panorámica del estado en que se encuentra el arte de la informatización de la atención primaria y la medicina general integral, en el mundo y en Cuba. Para ello, se sintetiza el origen prehistórico de ese nivel de atención y de la especialidad, así como el desarrollo contemporáneo de la informática y sus aplicaciones médicas; se define igualmente la atención primaria y su informática; se resumen los sistemas de información, las aplicaciones informáticas y sus desafíos; y se ofrece una visión práctica de la historia clínica-electrónica: corazón de la informática de atención primaria de salud y medicina general integral. Se concluye que Cuba ha trabajado 20 años informatizando la dispensarización y estadísticas para la gerencia de servicios de este nivel de atención, pero que también podría trabajar con el enfoque centrado en la vida del paciente, que contribuiría a crear una clasificación integradora de la salud con la enfermedad, y a computarizar la información y la toma de decisiones clínicas en el consultorio del médico, y en el futuro hasta en el hogar del paciente, elevando directamente la calidad de la atención primaria de salud.

  13. Sarcopenia is associated with an increased risk of advanced colorectal neoplasia.

    Science.gov (United States)

    Park, Youn Su; Kim, Ji Won; Kim, Byeong Gwan; Lee, Kook Lae; Lee, Jae Kyung; Kim, Joo Sung; Koh, Seong-Joon

    2017-04-01

    Although sarcopenia is associated with an increased risk for mortality after the curative resection of colorectal cancer, its influence on the development of advanced colonic neoplasia remains unclear. This study included 1270 subjects aged 40 years or older evaluated with first-time screening colonoscopy at Seoul National University Boramae Health Care Center from January 2010 to February 2015. Skeletal muscle mass was measured with a body composition analyzer (direct segmental multifrequency bioelectrical impedance analysis method). Multiple logistic regression analysis was performed to determine whether sarcopenia is associated with advanced colorectal neoplasia. Of 1270 subjects, 139 (10.9%) were categorized into the sarcopenia group and 1131 (89.1%) into the non-sarcopenia group. In the non-sarcopenia group, 55 subjects (4.9%) had advanced colorectal neoplasia. However, in the sarcopenia group, 19 subjects (13.7%) had advanced colorectal neoplasia, including 1 subject with invasive colorectal cancer (0.7%). In addition, subjects with sarcopenia had a higher prevalence of advanced adenoma (P sarcopenia. According to the multiple logistic regression analysis adjusted for variable confounders, age (odds ratio 1.062, 95% confidence interval 1.032-1.093; P sarcopenia (odds ratio 2.347, 95% confidence interval 1.311-4.202; P = 0.004) were associated with an advanced colorectal neoplasia. Sarcopenia is associated with an increased risk of advanced colorectal neoplasia.

  14. Prevención primaria

    OpenAIRE

    Henao Gaviria, Luis Fernando

    1989-01-01

    Pretende este trabajo sobre "Prevención primaria" brindar en forma general una seria de conceptos sobre la salud y la enfermedad, las diferentes barreras que se pueden interponer para que esta no se presente o si se presenta sea lo menos virulenta posible, si deja secuelas buscar que el paciente las trate de superar y evitar la muerte, se logra lo anterior aplicando los niveles de prevención de Leavell y Clark, se hará enfasis en el 1° y 2° nivel que corresponden al fomento o promoción de la ...

  15. Hipertermia maligna no Brasil: análise da atividade do hotline em 2009

    Directory of Open Access Journals (Sweden)

    Helga Cristina Almeida da Silva

    2013-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Hipertermia maligna (HM é doença farmacogenética, com reação hipermetabólica anormal a anestésicos halogenados e/ou relaxantes musculares despolarizantes. Desde 1991 há um serviço hotline de atendimento telefônico para HM no Brasil, disponível 24 horas por dia, em São Paulo. Este artigo analisa a atividade do serviço brasileiro de hotline para HM em 2009. MÉTODOS: Análise prospectiva de todas chamadas telefônicas paria maligna (HM é doença farmacogenética, com reação hipermetabólica anormal a anestésicos halogenados e/ou relaxantes musculares despolarizantes. Desde 1991 há um serviço hotline de atendimento telefônico para HM no Brasil, disponível 24 horas por dia, em São Paulo. Este art go analisa a at vidade do serviço brasileiro de hotline para HM em 2009a o serviço brasileiro de hotline para HM, de janeiro a dezembro de 2009. RESULTADOS: Foram recebidas 22 ligações; 21 provenientes do Sul-Sudeste do Brasil e uma do Norte. Quinze eram pedidos de informações gerais sobre HM. Sete foram suspeitas de crises agudas de HM, das quais duas não foram consideradas como HM. Nas cinco crises compatíveis com HM, todos os pacientes receberam anestésicos inalatórios halogenados (2 isoflurano, 3 sevoflurano e um usou também succinilcolina; havia quatro homens e uma mulher, com média de idade de 18 anos (2-27. Problemas descritos nas cinco crises de HM: taquicardia (cinco, aumento do gás carbônico expirado (quatro, hipertermia (três, acidemia (um, rabdomiólise (um e mioglobinúria (um. Um paciente recebeu dantrolene. Todos os cinco pacientes com crises de HM foram seguidos em unidade de terapia intensiva e recuperaram-se sem sequelas. A suscetibilidade à HM foi posteriormente confirmada em dois pacientes por meio do teste de contratura muscular in vitro. CONCLUSÕES: O número de chamadas por ano no serviço brasileiro de hotline para HM ainda é reduzido. As características das crises

  16. Lesiones premalignas y malignas de cérvix en adolescentes y mujeres jóvenes. Clínica Maternidad Rafael Calvo, Cartagena

    Directory of Open Access Journals (Sweden)

    Ivette Marina Romero Pérez, MD* Clarena Ceballos Díaz, MD** Álvaro Monterrosa Castro, MD**

    2009-04-01

    Full Text Available Objetivo: Determinar la frecuencia de lesiones premalignas y malignas de cérvix en adolescentes y mujeres jóvenes. Métodos: Estudio descriptivo transversal de 136 historias clínicas de pacientes entre 14 y 24 años remitidas al Servicio de Patología Cervical de Clínica Maternidad Rafael Calvo. Se evaluaron citología, colposcopia y estudio histopatológico. Resultados: La edad media fue de 21,0 (DE 2,4 años, la de inicio de vida sexual de 16,0 (DE 1,9 y la del primer embarazo 15,0 (DE 6,1 años. El 51,4% informaron dos o más compañeros sexuales. Treinta y seis (26,4% eran adolescentes y 100 (73,6% adultas jóvenes de 20 a 24 años. El 48,5% de toda la población tuvo citología anormal. Se observaron hallazgos colposcópicos de lesiones premalignas en 48 pacientes (35,3%: 12 adolescentes y 36 adultas. Se realizaron 50 biopsias: 39 (78,0% resultaron con lesiones de bajo grado, nueve (18,0% lesiones de alto grado y una (2% con cáncer de cérvix infiltrante. No se observó diferencia estadísticamente significativa entre la frecuencia de LIE de bajo o alto grado entre adolescentes y adultas jóvenes. En las pacientes con lesiones de alto grado y cáncer se observó una mayor frecuencia de inicio de vida sexual antes de 16 años y más de un compañero sexual. Conclusión. Se observó una mayor frecuencia de lesiones premalignas y malignas que las descritas en otros estudios. Nuevas evaluaciones deben inferir las causas que influyen en el incremento en la presencia de LIE a edades tempranas. [Romero IM, Ceballos C, Monterrosa A. Lesiones premalignas y malignas de cérvix en adolescentes y mujeres jóvenes. Clínica Maternidad Rafael Calvo, Cartagena. MedUNAB 2009; 12: 14-18].

  17. Canine oral cavity neoplasias - Brief review

    Directory of Open Access Journals (Sweden)

    João Filipe Requicha

    2015-03-01

    Full Text Available ABSTRACT. Requicha J.F., Pires M. dos A., Albuquerque C.M. & Viegas C.A. [Canine oral cavity neoplasias - Brief review.] Neoplasias da cavidade oral do cão - Breve revisão. Revista Brasileira de Medicina Veterinária, 37(1:41-46, 2015. Faculdade de Medicina Veterinária, Universidade Lusófona de Humanidades e Tecnologias, Campo Grande, 1749-024 Lisboa, Portugal e Department of Veterinary Sciences, School of Agriculture and Veterinary Sciences, University of Trás-os-Montes e Alto Douro, P.O. Box 1013, 5001-801 Vila Real, Portugal. E-mail: jfrequicha@gmail.com Oral proliferative lesions are relatively common in domestic carnivores but, fortunately, a lot of these lesions are benign. The oral cavity is place of 6% of all tumours in dogs, being the sixth most important localization of neoplasias in this specie. The non-odontogenic tumors arise from structures of the oral cavity, except from dental tissue, and they are mostly malignant. Odontogenic tumors are those originated from the dental structures. In the case of tumors of non-odontogenic, will be described the oral papillomatosis, the melanoma, the squamous cell carcinoma, and the fibrosarcoma. Among the odontogenic tumors, the focus will be on the epulides, ameloblastoma, odontoma and dentigerous cysts.

  18. Dietary habits of colorectal neoplasia patients in comparison to their first-degree relatives.

    Science.gov (United States)

    Kajzrlikova, Ivana Mikoviny; Vitek, Petr; Chalupa, Josef; Dite, Petr

    2014-05-07

    To compare the dietary habits between colorectal neoplasia patients, their first-degree relatives, and unrelated controls. From July 2008 to April 2011, we collected epidemiological data relevant to colorectal cancer from patients with colorectal neoplasias, their first-degree relatives, and also from a control group consisting of people referred for colonoscopy with a negative family history of colorectal cancer and without evidence of neoplasia after colonoscopic examination. The first-degree relatives were divided into two groups following the colonoscopic examination: (1) patients with neoplasia or (2) patients without neoplasia. Dietary habits of all groups were compared. A χ (2) test was used to assess the association between two dichotomous categorical variables. The study groups consisted of 242 patients with colorectal neoplasias (143 men, 99 women; mean age: 64 ± 12 years) and 160 first-degree relatives (66 men, 94 women; mean age: 48 ± 11 years). Fifty-five of the first-degree relatives were found to have a neoplastic lesion upon colonoscopy, while the remaining 105 were without neoplasia. The control group contained 123 individuals with a negative family history for neoplastic lesions (66 men, 57 women; mean age: 54 ± 12 years). Two hypotheses were tested. In the first, the dietary habits of first-degree relatives with neoplasia were more similar to those of patients with neoplasia, while the dietary habits of first-degree relatives without neoplasia were similar to those of the control group. In the second, no sex-related differences in dietary habits were expected between the particular groups. Indeed, no significant differences were observed in the dietary habits between the groups of patients, controls and first-degree relatives with/without neoplastic lesions. Nevertheless, statistically significant sex-related differences were observed in all groups, wherein women had healthier dietary habits than men. In all groups examined, women had

  19. Defining the genetic susceptibility to cervical neoplasia-A genome-wide association study.

    Directory of Open Access Journals (Sweden)

    Paul J Leo

    2017-08-01

    Full Text Available A small percentage of women with cervical HPV infection progress to cervical neoplasia, and the risk factors determining progression are incompletely understood. We sought to define the genetic loci involved in cervical neoplasia and to assess its heritability using unbiased unrelated case/control statistical approaches. We demonstrated strong association of cervical neoplasia with risk and protective HLA haplotypes that are determined by the amino-acids carried at positions 13 and 71 in pocket 4 of HLA-DRB1 and position 156 in HLA-B. Furthermore, 36% (standard error 2.4% of liability of HPV-associated cervical pre-cancer and cancer is determined by common genetic variants. Women in the highest 10% of genetic risk scores have approximately >7.1% risk, and those in the highest 5% have approximately >21.6% risk, of developing cervical neoplasia. Future studies should examine genetic risk prediction in assessing the risk of cervical neoplasia further, in combination with other screening methods.

  20. Neurocutaneous spectrum of multiple endocrine neoplasia-1

    Directory of Open Access Journals (Sweden)

    Shireen Furtado

    2012-01-01

    Full Text Available Multiple endocrine neoplasia type I or Wermer syndrome is characterized by primary hyperparathyroidism, enteropancreatic endocrine tumor, and a pituitary pathology. A 35-year-old male presented with visual field defects, hyperprolactinemia, and hypogonadism. He also had multiple infraumbilical skin-colored nodules. A syndromal association of Wermer syndrome was derived using the dermal, pituitary, parathyroid, and gastrointestinal hormonal manifestations of the tumor. The radiological and histological findings of lesion which underwent biopsy are discussed. The presence of collagenomas, lipomas, and hypopigmented macules in a patient with neuroendocrine symptoms should raise the suspicion of an underlying multiple endocrine neoplasia.

  1. Importance of thoracic radiography in the approach of animals with neoplasia/ A importância do exame radiográfico torácico na abordagem de animais portadores de neoplasias

    Directory of Open Access Journals (Sweden)

    Antonio Carlos Faria dos Reis

    2008-08-01

    Full Text Available The aim of the present study was to evaluate the importance of the thoracic radiography in dogs and cats with neoplasias of diverse origins and localizations, excepting mammary neoplasm. It was studied 54 animals on suspicion of pulmonary metastase and/or primary lung tumors- 49 dogs (91% and five cats (9%; being 28 (52% female (3 cats and 26 (48% male (2 cats – attended by Thoracic and Oncology Medicine Services in the Veterinary Hospital/UEL, in 2005. The mammary neoplasias were not included in this work. From the 54 animals, six (11% presented radiography examinations with evidence of pulmonary metastase, being one cat. Four animals (8% had compatible radiography examination with primary pulmonary neoplasia. These results indicate the importance of the thoracic radiography in the approach of animals with neoplasia, to exclude the possibility of pulmonary metastase independent from the neoplasm origin and the necessity of radiographic attendance to the animals without radiographic signals of pulmonary metastase.O objetivo deste trabalho foi avaliar a importância do exame radiográfico torácico em cães e gatos com neoplasias de diversas origens e localizações, excetuando neoplasias mamárias. Foram estudados 54 animais com suspeita de metástase pulmonar e/ou neoplasia pulmonar primária – 49 cães (91% e cinco felinos (9%; sendo 28 (52% fêmeas (3 felinas e 26 (48% machos (2 felinos – atendidos nos Projetos de Extensão em Medicina Torácica e Oncologia do Hospital Veterinário/UEL, durante o ano de 2005. As neoplasias mamárias, não foram inclusas neste trabalho. Dos 54 animais, seis (11% apresentaram exames radiográficos com evidência de metástase pulmonar, sendo um felino. Quatro animais (8% tiveram exame radiográfico compatível com neoplasia pulmonar primária. Esses resultados indicam a importância do exame radiográfico torácico na abordagem de animais com neoplasias, para descartar a possibilidade de met

  2. Radiographic findings in cats with intranasal neoplasia or chronic rhinitis: 29 cases (1982-1988)

    International Nuclear Information System (INIS)

    O'Brien, R.T.; Evans, S.M.; Wortman, J.A.; Hendrick, M.J.

    1996-01-01

    Objective: To compare radiographic findings and determine useful criteria to differentiate between intranasal neoplasia and chronic rhinitis in cats. Design: Retrospective study. Animals: Cats with chronic nasal disease caused by neoplasia (n = 18) or by chronic rhinitis (n = 11). Procedure: Radiographs were reviewed by 3 radiologists, followed by group review. Diagnosis was determined by intranasal biopsy or necropsy, and specimens were reviewed by a pathologist to confirm cause and histologic diagnosis. Results: Lymphosarcoma was the most common (n = 5) of the 6 histopathologic types in the neoplasia group. Cats in the neoplasia and chronic rhinitis groups had a high prevalence of aggressive radiographic lesions. Prevalence of a facial mass in cats with neoplasia (8/18) versus in those with chronic rhinitis (4/11) and of deviation (9/18 vs 6/11, respectively) or lysis (12/18 vs 7/11) of the nasal septum was similar. However, significantly (P = 0.02) more cats with neoplasia than with chronic rhinitis (13/16 vs 3/7, respectively) had unilateral turbinate destruction/lysis. Additionally, unilateral lateral bone erosion and loss of teeth associated with adjacent intranasal disease were more prevalent in cats with neoplasia (7/8 and 5/18, respectively) than in cats with chronic rhinitis (1/3 and 0/11, respectively). Clinical Implications: Features that may assist in radiographic diagnosis of neoplasia include the appearance of unilateral aggressive lesions, such as lysis of lateral bones, nasal turbinate destruction, and loss of teeth. Bilaterally symmetric lesions are more suggestive of chronic rhinitis than of neoplasia

  3. Dermoscopic clues to differentiate facial lentigo maligna from pigmented actinic keratosis.

    Science.gov (United States)

    Lallas, A; Tschandl, P; Kyrgidis, A; Stolz, W; Rabinovitz, H; Cameron, A; Gourhant, J Y; Giacomel, J; Kittler, H; Muir, J; Argenziano, G; Hofmann-Wellenhof, R; Zalaudek, I

    2016-05-01

    Dermoscopy is limited in differentiating accurately between pigmented lentigo maligna (LM) and pigmented actinic keratosis (PAK). This might be related to the fact that most studies have focused on pigmented criteria only, without considering additional recognizable features. To investigate the diagnostic accuracy of established dermoscopic criteria for pigmented LM and PAK, but including in the evaluation features previously associated with nonpigmented facial actinic keratosis. Retrospectively enrolled cases of histopathologically diagnosed LM, PAK and solar lentigo/early seborrhoeic keratosis (SL/SK) were dermoscopically evaluated for the presence of predefined criteria. Univariate and multivariate regression analyses were performed and receiver operating characteristic curves were used. The study sample consisted of 70 LMs, 56 PAKs and 18 SL/SKs. In a multivariate analysis, the most potent predictors of LM were grey rhomboids (sixfold increased probability of LM), nonevident follicles (fourfold) and intense pigmentation (twofold). In contrast, white circles, scales and red colour were significantly correlated with PAK, posing a 14-fold, eightfold and fourfold probability for PAK, respectively. The absence of evident follicles also represented a frequent LM criterion, characterizing 71% of LMs. White and evident follicles, scales and red colour represent significant diagnostic clues for PAK. Conversely, intense pigmentation and grey rhomboidal lines appear highly suggestive of LM. © 2015 British Association of Dermatologists.

  4. Genetics of Endocrine and Neuroendocrine Neoplasias (PDQ®)—Health Professional Version

    Science.gov (United States)

    Genetics of Endocrine and Neuroendocrine Neoplasias discusses inherited syndromes multiple endocrine neoplasia types 1, 2, and 4 (MEN1, MEN2, MEN4), familial pheochromocytoma and paraganglioma, Carney-Stratakis syndrome, and familial nonmedullary thyroid cancer. Learn more in this clinician summary.

  5. Long-term adherence to follow-up after treatment of cervical intraepithelial neoplasia

    DEFF Research Database (Denmark)

    Barken, Sidsel S; Lynge, Elsebeth; Andersen, Erik S.

    2013-01-01

    OBJECTIVE: To measure adherence to annual follow-up among women treated for cervical intraepithelial neoplasia. DESIGN: Prospective, population-based, register study. SETTING: Denmark, 1996-2007. POPULATION: All women treated for cervical intraepithelial neoplasia with conization. METHODS: Treated...... was poor in Denmark. Our findings suggest that because of this poor adherence, recommendations for long-term annual follow-up after treatment of cervical intraepithelial neoplasia may not be highly effective. Shorter follow-up schedules using highly sensitive tests appear attractive....

  6. p53 tumor suppressor gene: significance in neoplasia - a review

    International Nuclear Information System (INIS)

    Alam, J.M.

    2000-01-01

    p53 is a tumor suppressor gene located on chromosome 17p13.1. Its function includes cell cycle control and apoptosis. Loss of p53 function, either due to decreased level or genetic transformation, is associated with loss of cell cycle control, decrease, apoptosis and genomic modification, such mutation of p53 gene is now assessed and the indicator of neoplasia of cancer of several organs and cell types, p53 has demonstrated to have critical role in defining various progressive stages of neoplasia, therapeutic strategies and clinical application. The present review briefly describes function of p53 in addition to its diagnostic and prognostic significance in detecting several types of neoplasia. (author)

  7. Spectrum of ocular surface squamous neoplasia

    International Nuclear Information System (INIS)

    Babar, T.F.; Khan, M.N.; Hussain, M.; Shah, S.A.

    2007-01-01

    To describe the pattern of ocular surface squamous neoplasia (OSSN), clinical presentations, the risk factors and treatment options. The study included 36 eyes of 35 patients with biopsy-proven ocular surface neoplasia. The details of patients regarding age, gender, laterality and risk factors were entered into a specially-designed proforma. Each patient was also assessed biomicroscopically for type and complications of ocular surface neoplasia. The frequency of OSSN was 0.37 among admitted hospital patients. Among 36 cases of OSSN, squamous cell carcinoma of the conjunctiva was the most common type of OSSN seen in 63.9%, followed by carcinoma in situ of conjunctiva in 25% and carcinoma in situ of cornea in 11.1%. Male patients outnumbered female (65.7% vs 34.3%) with 71.42% of patients above 60 years of age. The risk factors identified were: old age, ultraviolet B exposure and xeroderma pigmentosa. Treatment consisted of local resection with or without adjuvant therapy in 61.1%, exenteration in 30.5%, enucleation in 5.5% and chemo/radiotherapy in 2.7%. Intraocular invasion was seen in 5.5% and orbital spread in 30.5%. The frequency of OSSN was 0.37% among admitted patients. Identification of exact etiological factors will enable to formulate strategies that are likely to decrease the incidence of this disease and the associated morbidity and mortality. (author)

  8. A score to estimate the likelihood of detecting advanced colorectal neoplasia at colonoscopy.

    Science.gov (United States)

    Kaminski, Michal F; Polkowski, Marcin; Kraszewska, Ewa; Rupinski, Maciej; Butruk, Eugeniusz; Regula, Jaroslaw

    2014-07-01

    This study aimed to develop and validate a model to estimate the likelihood of detecting advanced colorectal neoplasia in Caucasian patients. We performed a cross-sectional analysis of database records for 40-year-old to 66-year-old patients who entered a national primary colonoscopy-based screening programme for colorectal cancer in 73 centres in Poland in the year 2007. We used multivariate logistic regression to investigate the associations between clinical variables and the presence of advanced neoplasia in a randomly selected test set, and confirmed the associations in a validation set. We used model coefficients to develop a risk score for detection of advanced colorectal neoplasia. Advanced colorectal neoplasia was detected in 2544 of the 35,918 included participants (7.1%). In the test set, a logistic-regression model showed that independent risk factors for advanced colorectal neoplasia were: age, sex, family history of colorectal cancer, cigarette smoking (padvanced neoplasia: 1.00 (95% CI 0.95 to 1.06)) and had moderate discriminatory power (c-statistic 0.62). We developed a score that estimated the likelihood of detecting advanced neoplasia in the validation set, from 1.32% for patients scoring 0, to 19.12% for patients scoring 7-8. Developed and internally validated score consisting of simple clinical factors successfully estimates the likelihood of detecting advanced colorectal neoplasia in asymptomatic Caucasian patients. Once externally validated, it may be useful for counselling or designing primary prevention studies. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  9. Cistoadenocarcioma mucinoso de ovário e esclerose sistêmica Ovarian mucinous cystadenocarcinoma and systemic sclerosis

    Directory of Open Access Journals (Sweden)

    Maíta Poli de Araújo

    2004-02-01

    Full Text Available O câncer de ovário é a terceira causa de morte entre as neoplasias malignas em mulheres e o cistoadenocarcinoma mucinoso é uma neoplasia maligna originária do epitélio ovariano e que pode adquirir grandes dimensões. Alguns estudos sugerem um aumento do risco de neoplasia em pacientes com esclerose sistêmica (ES, mas a associação com neoplasia de ovário, principalmente do subtipo mucinoso, não é comum. Os autores descrevem um caso de cistoadenocarcinoma mucinoso de ovário em uma mulher branca de 52 anos com diagnóstico de ES difusa há seis anos, tratada previamente com D-penicilamina e ciclofosfamida, que procurou o serviço médico com queixa de dor e aumento do volume abdominal há três meses. Ao exame físico apresentava facies esclerodérmica, membros superiores com diminuição da elasticidade e enxerto bitibial em membros inferiores; no abdome havia a presença de uma massa endurecida estendendo-se da região suprapúbica até o epigástrio. Foi realizada laparotomia exploradora onde se encontrou uma massa cística no ovário direito, com peso de 3.300 gramas. Em seguida procedeu-se exérese do tumor com histerectomia total e ooforectomia bilateral. O exame histológico confirmou tratar-se de um cistoadenocarcinoma mucinoso sem invasão de cápsula.Ovarian cancer is the third cause of death among malignant neoplasia in women, and the mucinous cystadenocarcinoma is a malignant neoplasia of the ovarian epithelium, which may achieve great dimensions. Some studies suggest an increased risk of neoplasia in patients with systemic sclerosis (SSc, but the association with ovarian neoplasia, specially the mucinous subtype, is rare. The authors describe a case of ovarian mucinous cystoadenocarcinoma in a 52 year-old Caucasian woman who had the diagnosis of SSc 6 years ago, previously treated with cyclophosphamide and D-penicillamine, who sought for a medical service complaining of pain and increase of abdominal volume during the last

  10. Diabetes mellitus tipo 2 y osteoartritis primaria de rodilla

    Directory of Open Access Journals (Sweden)

    Rubén Daniel Arellano-Pérez Vertti

    2017-07-01

    Full Text Available Señor editor: Es nuestro interés dar a conocer los resultados del estudio sobre la asociación entre diabetes tipo 2 y osteoartritis primaria de rodilla en una población del norte de México.

  11. Atención Primaria de la Salud en Debate

    Directory of Open Access Journals (Sweden)

    Mario Rovere

    Full Text Available La Atención Primaria de la Salud, un concepto amplio y difundido, es colocado en debate en el presente artículo. Sin embargo, esa es, una tarea nada sencilla, dado el fuerte carácter idealista de sus principios y postulados. A través de diversos mecanismos, como develar sus antecedentes inmediatos y remotos, la detección de modelos en conflicto, de contradicciones conceptuales y el uso extensivo de preguntas, diversas afirmaciones doctrinarias, que parecen de toda obviedad, son puestas en entredicho. Se invita así al lector/a a una 'deconstrucción' del concepto de Atención Primaria de la Salud, de cara a producir nuevas propuestas más estratégicas y eficaces para que los trabajadores de salud, donde quiera que se desempeñen, cuenten con herramientas para enfrentar la creciente mercantilización del sector.

  12. Multiple endocrine neoplasia type I

    International Nuclear Information System (INIS)

    Fischer, H.J.; Lois, J.F.; Gomes, A.S.

    1985-01-01

    A case of multiple endocrine neoplasia (Men) consisting of an unusual combination of an insulin-producing islet cell tumour and an adrenal adenoma is reported. CT clearly demonstrated the adrenal mass whereas the pancreatic lesion remained questionable. Conversely angiography located the pancreatic tumour but the adrenal findings were subtle. (orig.)

  13. Molecular biological factors in the diagnosis of cervical intraepithelial neoplasias

    Directory of Open Access Journals (Sweden)

    Yu. N. Ponomareva

    2010-01-01

    Full Text Available The authors have made a complex analysis of the molecular biological factors associated with cervical intraepithelial neoplasia. They have revealed that infection by oncogenic human papillomavirus types is associated with suppressed apoptosis and enhanced cellular proliferative activity, which can be effectively used in the diagnosis and prediction of cervical neoplasias to optimize management tac- tics and to improve the results of treatment.

  14. Neoplasia intra-epitelial cervical: diagnóstico e tratamento Cervical intraepithelial neoplasia: diagnosis and treatment

    Directory of Open Access Journals (Sweden)

    Sophie Françoise Mauricette Derchain

    2005-07-01

    Full Text Available O câncer do colo uterino é hoje doença passível de prevenção secundária. Os métodos de detecção das lesões precursoras e da infecção pelo papilomavírus humano, tais como a citologia oncológica e biologia molecular, são de uso mundialmente difundido. Entretanto, ainda há muita controvérsia em relação à aplicação destes métodos na prática ginecológica. Qual o melhor exame ou a melhor associação de exames que podem ser utilizados, com que intervalo e em quais mulheres permanecem questões que com freqüência geram ansiedade nos consultórios ou nas unidades de saúde. Por outro lado, uma vez detectada a infecção viral ou a neoplasia intra-epitelial cervical, o tratamento dessas mulheres ainda não é consensual e muitos fatores interferem na definição da conduta ótima. O tipo de infecção, gravidade da neoplasia intra-epitelial, tipo histológico encontrado, todos estes aspectos tendem a dificultar o planejamento terapêutico. Esta revisão tem como objetivo abordar, dentro do conhecimento atual e baseado nos consensos vigentes no país, vários aspectos relacionados ao rastreamento das lesões cervicais e as possíveis condutas terapêuticas vigentes.Cervical cancer is nowadays a disease amenable to secondary prevention. Methods for the detection of its precursor lesions and human papillomavirus infection, such as cervical cytology and molecular biology, achieved widespread use worldwide. However, there is still too much controversy regarding the use of these methods in gynecological practice. Which is the best examination or the best association of examinations, and the most adequate time intervals to proceed with screening, are still pending questions, generating anxiety in patients and doctors. On the other hand, the management of women who have been diagnosed with viral infection and/or cervical intraepithelial neoplasia is not yet consensual, and several factors may affect the clinical decision on how to

  15. Freqüência de Neoplasia Intra-epitelial Cervical em Portadoras do Vírus da Imunodeficiência Humana Frequency of Cervical Intraepithelial Neoplasia in Human Immunodeficiency Virus-infected Women

    Directory of Open Access Journals (Sweden)

    Antonio Pedro Flores Auge

    2000-10-01

    Full Text Available Objetivo: verificar a freqüência de neoplasia intra-epitelial cervical (NIC em mulheres infectadas pelo vírus da imunodeficiência humana (HIV. Métodos: foram estudadas 99 mulheres HIV-soropositivas; o diagnóstico da infeccão pelo HIV foi realizado por meio de dois testes ELISA, complementados por teste Western blot ou de imunofluorescência indireta. Como grupo controle foram analisadas 104 mulheres que não apresentavam positividade no teste ELISA. Em ambos os grupos o rastreamento de NIC foi realizado por meio da associação de colpocitologia oncológica e colposcopia. Nos casos em que a colposcopia revelou existência de zonas de transformação anormal, o diagnóstico de NIC foi realizado mediante biopsia dirigida, complementada ou não por conização. Resultados: em 15 das 99 pacientes do grupo de estudo (15,2% foi encontrada neoplasia intra-epitelial cervical, sendo dez casos de NIC I, um de NIC II e quatro de NIC III. Entre as 104 mulheres do grupo controle, quatro (3,8% eram portadoras de neoplasia intra-epitelial cervical, encontrando-se um caso de NIC I e três de NIC III. Conclusão: a análise comparativa dos resultados evidenciou que a freqüência de neoplasia intra-epitelial cervical foi significantemente mais elevada entre as pacientes infectadas pelo HIV.Purpose: to verify the frequency of cervical intraepithelial neoplasia in human immunodeficiency virus (HIV ¾ infected women. Methods: ninety-nine HIV-seropositive women were studied. The diagnosis of the HIV infection was established through two ELISA tests complemented by Western blot test or indirect immunofluorescence test. As control group, 104 women whose ELISA test was not positive were analyzed. The investigation of cervical intraepithelial neoplasia was achieved by association of Pap smear and colposcopy in both groups. In the cases where colposcopy revealed existence of abnormal transformation zones, NIC diagnosis was obtained through colposcopy-guided biopsy

  16. Neoplasia intraepitelial vulvar: um problema atual Vulvar intraepithelial neoplasia: a current problem

    Directory of Open Access Journals (Sweden)

    José Alberto Fonseca-Moutinho

    2008-08-01

    Full Text Available A neoplasia intraepitelial da vulva (VIN é uma denominação que foi introduzida incialmente pela International Society for Study of Vulvo-vaginal Diseases (ISSVD e reconhecida posteriormente pela International Society of Gynaecological Pathology (ISGYP e Organização Mundial da Saúde. É uma entidade patológica a que correspondem as VIN de tipo usual (verrucoso, basalióide e misto e as VIN de tipo diferenciado. A incidência das lesões de VIN tem aumentado progressivamente, principalmente em mulheres jovens. A infecção pelo papilomavírus humano (HPV de alto risco, pelo vírus da imunodeficiência humana (HIV, o tabagismo e a neoplasia intraepitelial do colo do útero, da vagina e região anal são factores de risco estabelecidos para as VIN. Não existem sintomas e sinais característicos das VIN, mas a doença se traduz sempre por lesões clinicamente identificáveis. A biópsia com o auxílio do colposcópio permite o diagnóstico. O tratamento da doença está sempre justificado pelo elevado risco de progressão para cancro invasivo. A excisão alargada das lesões ou a sua destruição com laser CO2 têm sido os métodos mais populares de tratamento. Independentemente do método terapêutico utilizado, as taxas de recidiva são elevadas, pelo que está aconselhada a vigilância apertada das doentes após tratamento. A terapêutica tópica com imiquimod se afigura promissora no tratamento das VIN. As vacinas profiláticas contra os tipos de HPV de alto risco prometem se tornar armas poderosas na prevenção primária da doença.Vulvar intraepithelial neoplasia (VIN is a pathological denomination coined by the International Society for Study of Vulvo-vaginal Diseases (ISSVD and adopted by the International Society of Gynaecological Pathology (ISGYP and by the World Health Organization. VIN is a heterogeneous pathological entity with a usual type (warty, basaloid and mixed and a differentiated type. The incidence of the disease is

  17. de primaria

    Directory of Open Access Journals (Sweden)

    Purificación Toledo Morales

    2014-01-01

    Full Text Available Las pizarras digitales interactivas (PDI son una innovación que en los últimos años ha ganado considerable presencia en las aulas de nuestro país. El objetivo principal de este estudio es investigar las percepciones que estudiantes y docentes de educación primaria tienen del uso de la PDI en el aula, así como los problemas a los que se enfrentan. Los hallazgos confirman que estudiantes y docentes aprueban el uso de esta nueva tecnología en la educación, siendo su uso mayor en la enseñanza de matemáticas, lengua y conocimiento del medio. El estudio muestra que los estudiantes creen que la PDI es efectiva en la mejora de diversos aspectos de su aprendizaje. La actitud positiva del docente hacia el uso de las nuevas tecnologías en la enseñanza juega un papel importante en la ejecución y el éxito del uso de la PDI. Por último, inferimos que las PDI no se emplean en todo su potencial.

  18. Neoplasia in Turner syndrome. The importance of clinical and screening practices during follow-up.

    Science.gov (United States)

    Larizza, Daniela; Albanesi, Michela; De Silvestri, Annalisa; Accordino, Giulia; Brazzelli, Valeria; Maffè, Gabriella Carnevale; Calcaterra, Valeria

    2016-05-01

    Turmer syndrome (TS) patients show increased morbidity due to metabolic, autoimmune and cardiovascular disorders. A risk of neoplasia is also reported. Here, we review the prevalence of neoplasia in a cohort of Turner patients. We retrospectively evaluated 87 TS women. Follow-up included periodic ultrasound of the neck, abdominal and pelvic organs, dermatologic evaluation and fecal occult blood test. Karyotype was 45,X in 46 patients. During follow-up, 63 girls were treated with growth hormone, 65 with estro-progestin replacement therapy and 20 with L-thyroxine. Autoimmune diseases were present in 29 TS. A total of 17 neoplasms in 14 out of 87 patients were found. Six skin neoplasia, 3 central nervous system tumors, 3 gonadal neoplasia, 2 breast tumors, 1 hepatocarcinoma, 1 carcinoma of the pancreas and 1 follicular thyroid cancer were detected. Age at tumor diagnosis was higher in 45,X pts than in those with other karyotypes (p = 0.003). Adenomioma gallbladdder (AG) was detected in 15.3% of the patients, with a lower age in girls at diagnosis with an associated neoplasia in comparison with TS without tumors (p = 0.017). No correlation between genetic make up, treatment, associated autoimmune diseases and neoplastia was found. In our TS population an increased neoplasia prevalence was reported. A high prevalence of AG was also noted and it might be indicative of a predisposition to neoplasia. Further studies are needed to define the overall risk for neoplasia, and to determine the role of the loss of the X-chromosome and hormonal therapies. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  19. Microparticles and Exosomes in Gynecologic Neoplasias

    NARCIS (Netherlands)

    Nieuwland, Rienk; van der Post, Joris A. M.; Lok Gemma, Christianne A. R.; Kenter, G.; Sturk, Augueste

    2010-01-01

    This review presents an overview of the functions of microparticles and exosomes in gynecologic neoplasias. Growing evidence suggests that vesicles released from cancer cells in gynecologic malignancies contribute to the hypercoagulable state of these patients and contribute to tumor progression by

  20. Estado Nutricional de Crianças e Adolescentes com Neoplasias Malignas Durante o Primeiro Ano Após o Diagnóstico

    Directory of Open Access Journals (Sweden)

    Roberta Dalle Molle

    2011-04-01

    Full Text Available Introdução: O tratamento antineoplásico causa, frequentemente, complicações gastrintestinais que, juntamente com alterações metabólicas, podem interferir no estado nutricional. Objetivo: Analisar a evolução do estado nutricional de crianças e adolescentes com neoplasias, durante o primeiro ano após o diagnóstico. Métodos: Estudo de coorte retrospectivo realizado no Serviço de Oncologia Pediátrica do Hospital de Clínicas de Porto Alegre com pacientes admitidos entre janeiro de 2001 e agosto de 2005, que possuíam registros de peso e estatura ao diagnóstico, ao terceiro, ao sexto e ao décimo segundo mês após o diagnóstico. Para classificar o estado nutricional utilizou-se o escore-Z do índice peso/estatura para as crianças e o índice de massa corporal para os adolescentes. Resultados: Foram avaliados 140 pacientes com mediana de idade ao diagnóstico de 4,75 anos (3,08 – 10,31, sendo 77 (55% pacientes do sexo masculino. Dos pacientes pesquisados, 86 (61% apresentavam doenças hematológicas e 54 (39% tumores sólidos. Os adolescentes, comparados às crianças, apresentaram maior prevalência de desnutrição e risco nutricional ao sexto (P =0,02 e ao décimo segundo mês (P =0,001. O comportamento das médias do escore-Z e do percentil do índice de massa corporal ao longo do primeiro ano foi diferente entre os grupos de pacientes com tumores sólidos e com doenças hematológicas, tanto para as crianças (P <0,001 como para os adolescentes (P =0,012. Conclusão: Os adolescentes, comparados às crianças, apresentaram prevalências maiores de desnutrição e risco nutricional. Os pacientes com tumores sólidos tiveram seu estado nutricional mais afetado do que aqueles com doenças hematológicas.

  1. Immunohistochemical localization of human papilloma virus in conjunctival neoplasias: A retrospective study

    Science.gov (United States)

    Sharma, Anjana; Panda, Anita

    2007-01-01

    Background: The extent of association of human papilloma virus (HPV) in human conjunctival neoplasias has been debated in studies originating from different parts of the world, but no substantial evidence has been generated on Indian subjects. This prompted us to carry out a retrospective study on conjunctival neoplasias diagnosed over the past 12 years. Materials and Methods: Histopathological and immunohistochemical analysis of 65 specimens of ocular neoplasias and 30 normal controls diagnosed between 1991 and 2002 at a tertiary eye care hospital, was undertaken. Formalin-fixed, paraffin-embedded tissues were reviewed for confirming histopathological diagnosis, presence of koilocytosis and changes related to actinic keratosis. Immunohistochemical analysis was done using HPV-specific monoclonal antibodies. Clinicopathological correlation and the association of HPV antigen with the histopathological features were performed. Results: Out of the 65 cases analyzed, 35 were papillomas and 30 were ocular surface squamous neoplasias (OSSN). The mean age was 48 years with a male preponderance. Histologically, koilocytosis was observed in 17.1% of papillomas and 36.6% of OSSN. Actinic keratosis was present in 33% of OSSN. Immunohistochemically 17.1% conjunctival papillomas stained positive for HPV antigen, all cases of OSSN were negative for HPV. There was no correlation between koilocytosis or actinic keratosis and the detection of HPV antigen. Conclusions: The association between HPV and conjunctival neoplasias is variable in different geographical areas and also depends on the methods of detection used. This study warrants the need for applying more advanced techniques at a molecular level to determine the possible etiology of HPV in conjunctival neoplasias among Asian-Indians. PMID:17699945

  2. Intrahepatic splenosis mimicking hepatic neoplasia

    Directory of Open Access Journals (Sweden)

    Gabriel Neves Saad Teles

    Full Text Available Introduction: Splenosis is defined as the heterotopic autoimplantation of splenic tissue following trauma to or surgery on the spleen. Clinical case: We present a case of an asymptomatic 73-year-old male in whom hypervascular lesions were detected during routine exams. The patient reported a history of carotid artery surgery and cholecystectomy; he had a laparotomy incision from childhood but was unaware of the reason for it. The patient exhibited slightly elevated carcinoembryonic antigen (CEA levels. Histopathology revealed intrahepatic heterotopic splenic parenchyma, with no evidence of neoplasia in either of the two lesions, the diameters of which were 1.5 cm and 3.6 cm. Patient received outpatient follow-up care for 24 months and experienced no complications. Discussion: Our clinical, laboratory, and imaging exams failed to reveal the etiology of the lesion. Because the masses were hypervascular lesions, a percutaneous liver biopsy was not feasible. Conclusion: Through this report, we emphasize the importance of considering intrahepatic splenosis as a remote possibility in patients with hepatic nodules who have a history of splenectomy. Keywords: Splenosis, Neoplasia, Liver, Splenectomy

  3. Adenocarcinoma y carcinoma tipo linfoepitelioma sincrónico en estómago: presentación de un caso y revisión de la literatura

    Directory of Open Access Journals (Sweden)

    D. Aranguibel

    2012-04-01

    Full Text Available El cáncer gástrico es una de las principales causas de muerte en el mundo. En Venezuela, las neoplasias gástricas representan 37% de todos los tumores malignos del sistema digestivo, pero el carcinoma tipo linfoepitelioma, sólo se presenta entre 1,6% y 3,1% de los casos. También es rara la presentación de lesiones tumorales sincrónicas. Al respecto se expone el caso clínico, el primero en este país, de un varón con 2 lesiones tumorales sincrónicas. Las lesiones lucían como incipientes, no obstante, el estudio histológico mostró 2 neoplasias malignas de estirpe epitelial: adenocarcinoma bien diferenciado y carcinoma tipo linfoepitelioma.

  4. Propuesta de intervención para consolidar hábitos lectores en alumnos de 6º de primaria

    OpenAIRE

    Carcaño-Sobré, Eva

    2015-01-01

    El Trabajo de Fin de Grado se plantea las características principales de los hábitos lectores de un grupo de edad de 11-12 años y como la lectura forma parte del currículum de Educación Primaria. Para ello se realiza un cuestionario a alumnos de sexto de Primaria para comprobar la importancia de la lectura en este grupo y posteriormente se realiza otro cuestionario dirigido a alumnos de Educación Segundaria Obligatoria para constatar si esos hábitos siguen siendo los mismos que en Primaria...

  5. RELANZAMIENTO ATENCIÓN PRIMARIA EN SALUD

    OpenAIRE

    Gustavo Malagón Londoño

    2011-01-01

    Con la memorable sesión, en el auditorio de la Academia Nacional de Medicina, ante autoridades de la salud, miembros del cuerpo docente de las universidades, representantes de las sociedades científicas y académicos, la Directora General de la Organización Panamericana de la Salud, Doctora Mirta Roses Periago, hizo el solemne relanzamiento de la Atención Primaria de Salud en las Américas, como una nueva estrategia renovada, probada a merced de nume...

  6. Programa Literatura Infantil Local para la carrera Licenciatura en Educación Primaria

    Directory of Open Access Journals (Sweden)

    Inalvis Basnueva-Cantillo

    2017-09-01

    Full Text Available En los planes de estudio vigentes para la carrera Licenciatura en Educación Primaria se ha concedido muy poco espacio para el desarrollo en los estudiantes del interés hacia la creación literaria del lugar donde vive, lo cual obstaculiza el rescate y promoción de los valores territoriales. En el trabajo se propone y fundamenta un programa de Literatura Infantil Local para la formación inicial de los estudiantes de la carrera Licenciatura en Educación Primaria, como resultado de la tesis de maestría de la autora principal.

  7. Endoscopic submucosal dissection for early Barrett's neoplasia.

    Science.gov (United States)

    Barret, Maximilien; Cao, Dalhia Thao; Beuvon, Frédéric; Leblanc, Sarah; Terris, Benoit; Camus, Marine; Coriat, Romain; Chaussade, Stanislas; Prat, Frédéric

    2016-04-01

    The possible benefit of endoscopic submucosal dissection (ESD) for early neoplasia arising in Barrett's esophagus remains controversial. We aimed to assess the efficacy and safety of ESD for the treatment of early Barrett's neoplasia. All consecutive patients undergoing ESD for the resection of a visible lesion in a Barrett's esophagus, either suspicious of submucosal infiltration or exceeding 10 mm in size, between February 2012 and January 2015 were prospectively included. The primary endpoint was the rate of curative resection of carcinoma, defined as histologically complete resection of adenocarcinomas without poor histoprognostic factors. Thirty-five patients (36 lesions) with a mean age of 66.2 ± 12 years, a mean ASA score of 2.1 ± 0.7, and a mean C4M6 Barrett's segment were included. The mean procedure time was 191 ± 79 mn, and the mean size of the resected specimen was 51.3 ± 23 mm. En bloc resection rate was 89%. Lesions were 12 ± 15 mm in size, and 81% (29/36) were invasive adenocarcinomas, six of which with submucosal invasion. Although R0 resection of carcinoma was 72.4%, the curative resection rate was 66% (19/29). After a mean follow-up of 12.9 ± 9 months, 16 (45.7%) patients had required additional treatment, among whom nine underwent surgical resection, and seven further endoscopic treatments. Metachronous lesions or recurrence of cancer developed during the follow-up period in 17.2% of the patients. The overall complication rate was 16.7%, including 8.3% perforations, all conservatively managed, and no bleeding. The 30-day mortality was 0%. In this early experience, ESD yielded a moderate curative resection rate in Barrett's neoplasia. At present, improvements are needed if ESD is to replace piecemeal endoscopic mucosal resection in the management of Barrett's neoplasia.

  8. Induced transdifferentiation of human B-leukemia/lymphoma cell lines and inhibition of leukemogenicity

    OpenAIRE

    Rapino, Francesca, 1982-

    2013-01-01

    Las neoplasias malignas de células B abarcan una amplia variedad de enfermedades diferentes, incluyendo el linfoma no Hodgkin (LNH) y leucemia. Actualmente, la quimioterapia, la radiación y el tratamiento con anticuerpos anti-CD20 son los pilares de la terapia contra el linfoma y la leucemia de células B. Sin embargo, el hecho de que un gran porcentaje de pacientes no se cura con estos tratamientos, justifica la búsqueda de nuevas terapias más eficaces. Aunque la inducció...

  9. Anal intraepithelial neoplasia in HIV+ men

    NARCIS (Netherlands)

    Richel, O.

    2014-01-01

    In this thesis we investigated several aspects of anal intraepithelial neoplasia (AIN) in HIV+ men who have sex with men (MSM). This condition has gained clinical interest because of the impressive increase of the anal cancer incidence in HIV+ MSM since the introduction of combination antiretroviral

  10. Fibrobronchoscopy in the lung neoplasia

    International Nuclear Information System (INIS)

    Machin Gonzalez, Victoriano; Vieito Espinneira, Rodolfo; Freyre Serentill, Juan C.; Benito Soler, Isabel

    1997-01-01

    160 patients with a clinical-radiological picture suggesting lung neoplasia was conducted. Fibrobronchoscopy was performed as a reliable method to detect this disease. Punch biopsy, exfoliative cytology, and bronchial lavage Webre used to obtain specimens for the histological study. Of all the patients studied, 112 cases Webre positive and a proper diagnosis by biopsy was attained in 90 of them

  11. Prostaglandin E2-induced colonic secretion in patients with and without colorectal neoplasia

    DEFF Research Database (Denmark)

    Kaltoft, Nicolai; Tilotta, Maria C; Witte, Anne-Barbara

    2010-01-01

    colorectal neoplasia. Patients without endoscopic findings of neoplasia served as controls. Biopsy specimens were obtained from normally appearing mucosa in the sigmoid part of colon. Biopsies were mounted in miniaturized modified Ussing air-suction chambers. Indomethacin (10 microM), various stimulators...

  12. En acción: mejorando el acceso a la atención óptima para todos los pacientes con inmunodeficiencias primarias Semana mundial de las Inmunodeficiencias Primarias

    Directory of Open Access Journals (Sweden)

    Francisco Espinosa Rosales

    2016-04-01

    Full Text Available Las inmunodeficiencias primarias constituyen un grupo de más de 300 defectos innatos del sistema inmunitario, tanto en sus componentes hematopoyéticos como en los no-hematopoyéticos. Dichos defectos pueden presentarse con un amplio espectro de manifestaciones clínicas, ya sea con infecciones (comunes recurrentes, comunes graves, o raras y graves, autoinflamación, autoinmunidad, malignidad y/o alergia. Anteriormente clasificadas como “enfermedades raras”, las inmunodeficiencias primarias no son tan raras como se pensaba: hoy en día se estima que afectan a más de seis millones de personas alrededor del mundo, sin distinciones geográficas, de género o edad.

  13. Caracterización de Atención Primaria de salud en tres municipios de Minas Gerais, Brasil: Un analisis de los casos

    Directory of Open Access Journals (Sweden)

    Luciano José ARANTES

    2011-12-01

    Full Text Available Este trabajo tuvo como objetivo estudiar la forma en que la atención primaria de salud se caracteriza en tres municipios de Minas Gerais, Brasil. Hemos tratado de comprender el contexto local, la estructura y la gestión de la atención primaria en los municipios pesquisados. Las técnicas utilizadas para la colecta de datos fueron la investigación documental y la entrevista con los gestores locales. Los datos obtenidos fueron analizados de acuerdo con la legislación brasileña para el desarrollo de la atención primaria. Se identificó que los municipios asumen la atención primaria de salud de manera distinta. La característica de la política y del gobierno local fue considerada un punto que parece permear tanto en el contexto del desarrollo de la atención primaria como su forma de estructuración y gestión.

  14. Gestational trophoblastic neoplasia: A 6 year retrospective study

    Directory of Open Access Journals (Sweden)

    Sushruta Shrivastava

    2014-01-01

    Full Text Available Aims and Objectives: To study the clinical presentations of gestational trophoblastic neoplasia and its response to chemotherapy. Materials and Methods: This is a retrospective study of 28 women of gestational trophoblastic neoplasia evaluated over a period of 6 years from January 2004 to December 2009. Patients were evaluated on the basis of their age, number of deliveries, history of abortion or molar pregnancy, and the treatment received. All patients were scored on the basis of WHO scoring system. Patients with low risk (score /=7 received multiple agent chemotherapy with EMACO regimen. After completion of chemotherapy patients were followed for a minimum of 2 years. The response to treatment was evaluated during follow-up by clinical examination, beta hCG levels and imaging as and when required. Results: Out of 28 women only 27 could be evaluated, because 1 patient was lost to follow-up. Out of 27 patients, 18 patients (66.67% achieved complete remission with the first-line chemotherapy and additional 25.92% (7/27 achieved complete remission with second line chemotherapy resulting in complete remission of 92.5% (25/27. Conclusion: Gestational trophoblastic neoplasia is curable if patient is properly evaluated and scored. It shows good response to chemotherapy.

  15. costarricenses de primaria y secundaria

    Directory of Open Access Journals (Sweden)

    Julián Monge Nájera

    2006-01-01

    Full Text Available En Costa Rica, la informática dejó de ser una “nueva tecnología” para ser parte cotidiana de la vida de docentes y estudiantes. Sin embargo, el valor y tipo de uso de las computadoras y otros componentes de la informática en la enseñanza-aprendizaje aún son sujeto de debate entre los teóricos de la educación. La discusión se centra en un aspecto teórico y otro práctico. El teórico: ¿debe enseñarse cómo funciona la computadora o debe enseñarse simplemente a usarla? El práctico: ¿conviene usar la informática durante las lecciones, o sólo como un complemento extra-clase? Tras consultar a 231 mujeres y hombres dedicados a la enseñanza primaria y secundaria en toda Costa Rica, se encontró que la mayoría está a favor de cómo enseñar a usar la computadora (más que cómo funciona, tanto en el aula como fuera de ella. Sin embargo, en la vida real usan la informática más en actividades administrativas que educativas, y no han aprovechado el verdadero potencial de la tecnología de la información y comunicación (TIC en educación, por lo cual no han cosechado los logros que se esperan de su uso. Es urgente entonces un giro radical en la forma en que se apoya al personal docente y en cómo se emplean realmente las computadoras en la educación primaria y secundaria de Costa Rica.

  16. Concurrent endocrine neoplasias in dogs and cats: a retrospective study (2004-2014).

    Science.gov (United States)

    Beatrice, Laura; Boretti, Felicitas Schär; Sieber-Ruckstuhl, Nadja S; Mueller, Claudia; Kümmerle-Fraune, Claudia; Hilbe, Monika; Grest, Paula; Reusch, Claudia E

    2018-03-17

    Multiple endocrine neoplasia (MEN) is a well-known syndrome in human medicine, whereas only a few cases of concurrent endocrine neoplasias have been reported in dogs and cats. The aim of this study was to evaluate the prevalence of concurrent endocrine neoplasias in dogs and cats at our clinic, identify possible breed and sex predispositions and investigate similarities with MEN syndromes in humans. Postmortem reports of 951 dogs and 1155 cats that died or were euthanased at the Clinic for Small Animal Internal Medicine, University of Zurich, between 2004 and 2014 were reviewed, and animals with at least two concurrent endocrine neoplasias and/or hyperplasias were included. Twenty dogs and 15 cats met the inclusion criteria. In dogs, the adrenal glands were most commonly affected. Multiple tumours affecting the adrenal glands and the association of these tumours with pituitary adenomas were the most common tumour combinations. Only one dog had a combination resembling human MEN type 1 syndrome (pituitary adenoma and insulinoma). In cats, the thyroid glands were most commonly affected and there were no similarities to human MEN syndromes. The prevalence of concurrent endocrine neoplasia was 2.1 per cent in dogs and 1.3 per cent in cats and MEN-like syndromes are very rare in these species. © British Veterinary Association (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  17. Use of mammary epithelial antigens as markers in mammary neoplasia

    International Nuclear Information System (INIS)

    Ceriani, R.L.; Peterson, J.A.; Blank, E.W.

    1979-01-01

    Cell-type specific antigens of the mammary epithelial cells can be used as markers of breast neoplasia. Methods are proposed for the detection of metastatic mammary tissue in vivo by injection of [ 125 I]-labeled antibodies against the mammary epithelial antigens. In addition, the reduced expression of mammary epithelial cell antigens in neoplastic breast cells, quantitated here on a cell per cell basis by flow cytofluorimetry, is a marker of neoplasia and an indication of a deletion accompanying the neoplastic transformation of these cells. (Auth.)

  18. Aspectos éticos en Pediatría, las inmunodeficiencias primarias

    Directory of Open Access Journals (Sweden)

    Martha Leonor Paradoa Pérez

    2012-12-01

    Full Text Available Las inmunodeficiencias primarias son enfermedades genéticas, caracterizadas por infecciones crónicas devastadoras que conllevan a la muerte, al desarrollo de tumores y a enfermedades autoinmunes, y la mayoría de estas enfermedades cursan en la edad pediátrica. Desde la última década del pasado siglo, el desarrollo de la tecnología, el surgimiento del Proyecto del Genoma Humano y la profundización en los aspectos bioéticos, han dado lugar a especificidades en la atención médica e investigativa del paciente pediátrico y del que desarrolla una enfermedad inmunológica. Este trabajo recoge los aspectos bioéticos más importantes y los dilemas éticos con los que se enfrenta el inmunólogo pediátrico en la atención al paciente con inmunodeficiencia primaria, el cual demanda la atención de, prácticamente, todas las especialidades pediátricas.

  19. Generalidades sobre os tumores renais

    Directory of Open Access Journals (Sweden)

    Cristina Knopp Tristão

    2008-01-01

    Full Text Available O aumento na incidência do carcinoma de células renais, na maior parte da população, deve-se em parte ao aumento do número de tumores detectados incidentalmente com novos métodos de diagnósticos por imagem. As sofisticações dos instrumentos diagnósticos e terapêuticos modificam as perspectivas dos pacientes com carcinoma de células renais. Um aumento na taxa de sobrevivência e uma redução da morbidade foram alcançados. As neoplasias malignas do trato gênito-urinário compreendem, aproximadamente, metade dos tumores diagnosticados em homens, e a incidência deste grupo de câncer aumenta com a idade. O carcinoma de células renais representa a terceira neoplasia gênito-urinária mais freqüente.

  20. Lobular neoplasia - borderline type of lesion - risk of subsequent development of invasive lobular carcinoma of the breast, 13 years after excision of radial scar with multifocal lobular neoplasia

    International Nuclear Information System (INIS)

    Wardzynska, K.; Wesolowska, E.; Baranska, J.

    2010-01-01

    Background. Lobular neoplasia is a hyperplastic breast lesion - a borderline type of lesion with a high risk of subsequent development of invasive carcinoma. In case of radial scar diagnosis the risk of invasive carcinoma increases twice in comparison with healthy patients population while in the case of lobular neoplasia diagnosis within radial scar this risk increases 8 to 10 times. Basing on the presented case we analyse and review the literature regarding the clinical, radiological and pathological aspects of lobular neoplasia of the breast. Case report. A 67-yeas old patient was hospitalised in 1995 in order to consult the results of mammography, which revealed a radial scar lesion of the right breast. The patient was then referred to undergo wide local excision. Pathological examination showed dysplastic changes of the radial scar type with 1 cm multifocal lobular neoplasia. The patient was systematically followed clinically and radiologically during the decade 1996-2006 and all examination results were normal. In 2008, an ill-defined nodule appeared within the scar on mammography examination. This was categorized as BI-RADS 4C. The mammotomic biopsy performed under ultrasonography control revealed invasive lobular carcinoma. The tumor was totally locally excised and the sentinel node was histologically verified. The histopathological examination revealed a 1.6 cm focus of invasive lobular carcinoma and the sentinel node was negative. Conclusion. Patients with detected lobular neoplasia should be treated as a risk group of invasive breast cancer development (30-40% vs 10% in a healthy population during the entire life period). Systematic clinical and radiological follow-up should be mandatory. (authors)

  1. Uso de las TICs en la enseñanza de la Biología en Educación Primaria

    OpenAIRE

    Puente Ciria, Esther

    2014-01-01

    El presente Trabajo de Fin de Grado se centra en la elaboración de diversos recursos educativos basados en las Tecnologías de la Información y la Comunicación (TICs) para la enseñanza de los contenidos de Biología a alumnos del segundo ciclo de Educación Primaria. En primer lugar, se llevará a cabo un análisis sobre la importancia de la Biología en Educación Primaria y los contenidos recogidos en la normativa vigente. Posteriormente, se analizará el uso de las TICs en Educación Primaria...

  2. Multiple endocrine neoplasia type 2: achievements and current challenges

    Directory of Open Access Journals (Sweden)

    Andreas Machens

    2012-01-01

    Full Text Available Incremental advances in medical technology, such as the development of sensitive hormonal assays for routine clinical care, are the drivers of medical progress. This principle is exemplified by the creation of the concept of multiple endocrine neoplasia type 2, encompassing medullary thyroid cancer, pheochromocytoma, and primary hyperparathyroidism, which did not emerge before the early 1960s. This review sets out to highlight key achievements, such as joint biochemical and DNA-based screening of individuals at risk of developing multiple endocrine neoplasia type 2, before casting a spotlight on current challenges which include: (i ill-defined upper limits of calcitonin assays for infants and young children, rendering it difficult to implement the biochemical part of the integrated DNA-based/biochemical concept; (ii our increasingly mobile society in which different service providers are caring for one individual at various stages in the disease process. With familial relationships disintegrating as a result of geographic dispersion, information about the history of the origin family may become sketchy or just unavailable. This is when DNA-based gene tests come into play, confirming or excluding an individual's genetic predisposition to multiple endocrine neoplasia type 2 even before there is any biochemical or clinical evidence of the disease. However, the unrivaled molecular genetic progress in multiple endocrine neoplasia type 2 does not come without a price. Screening may uncover unknown gene sequence variants representing either harmless polymorphisms or pathogenic mutations. In this setting, functional characterization of mutant cells in vitro may generate helpful ancillary evidence with regard to the pathogenicity of gene variants in comparison with established mutations.

  3. Teratocarcinosarcoma rinosinusal: Reporte de un caso

    OpenAIRE

    González G,Claudia; Iñiguez,Rodrigo; Aranís Jiménez,Carolina; Castiblanco Galvis,Adriana

    2008-01-01

    Teratocarcinosarcoma rinosinusal es una neoplasia maligna infrecuente y rara, que combina elementos de teratoma y carcinosarcoma. Se compone de epitelio benigno o maligno (fibroblastos), mesénquima (cartílago, hueso o músculo liso) y elementos neurales. Hasta el año 2008 se han reportado un total de 63 casos de ubicación rinosinusal. Presentamos el caso de un teratocarcinosarcoma de fosa nasal, en un hombre de 67 años de edad, que consultó por obstrucción nasal rápidamente progresiva. La lesi...

  4. ANATOMÍA PATOLÓGICA Y TUMORES HEREDITARIOS

    Directory of Open Access Journals (Sweden)

    Dra. M. Teresa Vial

    2017-07-01

    Nos referiremos desde el punto de vista patológico a algunas de las neoplasias malignas incluidas en síndromes de cáncer hereditario causados por los principales y más frecuentes genes de predisposición genética. Cáncer de Mama (BRCA1/2, Cáncer Colorectal no Polipósico/Síndrome de Lynch (MMR, Cáncer Gástrico Hereditario, Poliposis adenomatosa familiar (PAF, Cáncer Renal y Síndrome de von Hippel Lindau (VHL y Cáncer Medular de Tiroides (RET.

  5. Relación epitelio-conectivo en la carcinogénesis experimental bucal: variaciones de ploidía epitelial en relación a la expresión del factor de crecimiento fibroblástico-básico y fibrosis

    OpenAIRE

    Raimondi, Ana Rosa

    2003-01-01

    El modelo de la bolsa de la mejilla del hámster muy aceptado y utilizado, reproduce la cancerización de la boca humana y una fibrosis subepitelial semejante a la fibrosis de la submucosa. En el se han analizado extensamente las características de los tumores que produce, pero se ha prestado menos atención al estudio de las etapas previas a la aparición de tumores. Las neoplasias que se observan en el modelo se dan en forma focal, precedidas por lesiones pre-malignas muitifocales, en una clara...

  6. Efeitos metabólicos da suplementação dietética com Agaricus sylvaticus em pacientes com câncer colorretal em fase pós-operatória

    OpenAIRE

    Fortes, Renata Costa

    2011-01-01

    O câncer colorretal é um dos mais comuns tipos de neoplasias malignas. Pacientes com câncer apresentam diversas anormalidades metabólicas e nos parâmetros bioquímicos e enzimáticos, com repercussões significativas sobre a qualidade de vida. Os fungos Agaricus sylvaticus têm sido utilizados como suplementos dietéticos devido às suas propriedades nutricionais, farmacológicas e organolépticas. O objetivo deste estudo foi avaliar os efeitos metabólicos da suplementação dietética com fungos Agaric...

  7. Proceso de enfermería para hombres con cáncer de laringe fundamentado en el modelo de Neuman

    OpenAIRE

    Peres de Oliveira, Patrícia; Gimenez Amaral, Juliana; Bezerra Rodrigues, Andrea; Ribeiro da Silva, Myria; de Carvalho Onofre, Prinscilla Sete; Araújo da Silveira, Edilene Aparecida

    2017-01-01

    Resumen Objetivo Operar el proceso de enfermería propuesto por Betty Neuman para hombres con cáncer de laringe para la identificación de los factores de estrés y patrones de enfrentamiento desencadenados en la vivencia de la neoplasia maligna. Método Estudio exploratorio, descriptivo, cualitativo, se utilizó como referencial teórico el Modelo de Betty Neuman con 30 hombres sometidos a tratamiento de cáncer de laringe, que pertenecen a un grupo de apoyo que se encuentra en São Paulo, Brasil....

  8. Cutaneous manifestations of internal malignancies in a tertiary health care hospital of a developing country Manifestações cutâneas de doenças malignas em um hospital terciário de um país em desenvolvimento

    Directory of Open Access Journals (Sweden)

    Alex G Ortega-Loayza

    2010-10-01

    diagnosticada antes (45,8% ou no momento (38,5% do diagnóstico do tumor subjacente. Os tumores malignos mais frequentes foram linfoma, adenocarcinomas do trato digestivo superior e neoplasias malignas do pâncreas. A idade média dos pacientes foi de 47.0 ± 16.9 anos e a duração da doença desde o diagnóstico foi de 13,7 meses. A taxa de mortalidade foi de 75%. Dermatoses paraneoplásicas são condições dermatológicas raras de difícil diagnóstico. O controle também é prejudicado quando pacientes não têm acesso fácil à centros de saúde por questões financeiras ou geográficas. No entanto, quando identificadas, elas podem facilitar o diagnóstico precoce de um tumor associado e contribuir para um aumento do controle dos pacientes.

  9. Causas de fracaso de cirugía primaria del ligamento cruzado anterior en futbolistas catalanes

    OpenAIRE

    García, Santiago Gómez

    2013-01-01

    El gran incremento de las demandas deportivas y de actividad física de la población ha aumentado el número de cirugías primarias del ligamento cruzado anterior. El estudio identificó las causas potenciales de recidiva¹ de inestabilidad en un grupo de futbolistas federados sometidos a cirugía de revisión. Fueron estudiados retrospectivamente 17 casos de cirugías de revisión del ligamento cruzado anterior, de un total de 629 operaciones de estabilización primaria de rodilla, en el periodo compr...

  10. La relevancia de la autoestima en Educaci??n F??sica y la Educaci??n Primaria

    OpenAIRE

    Morilla Portela, Ignacio

    2015-01-01

    El siguiente trabajo es una revisi??n bibliogr??fica de la autoestima centrada en una de las etapas m??s influyentes para la configuraci??n de la misma, la Educaci??n Primaria. El objetivo del documento no es otro que el de indagar acerca de la relevancia de la autoestima en la Educaci??n Primaria as?? como en el ??rea de Educaci??n F??sica. Con tal prop??sito, se analizan tanto el concepto actual de la autoestima como los curr??culums oficiales, a raz??n de dilucidar la trascendencia que le ...

  11. Mujeres participando y construyendo: participación social en salud en atención primaria

    OpenAIRE

    Carrillo Franco, Janeth

    2013-01-01

    OBJETIVO: Describir las dinámicas culturales de la participación social en salud, identificadas en un grupo de mujeres de un territorio de Atención Primaria en Salud en Bogotá. METODOLOGÍA :La investigación cualitativa con historia oral fue desarrollada con un grupo de seis mujeres líderes comunitarias del territorio de Atención Primaria de San Luis, Bogotá, entre septiembre de 2010 y diciembre de 2011. Fueron analizadas de forma inductiva e interpretativa. Emergió un tema cultural y dos...

  12. Piroxicam decreases postirradiation colonic neoplasia in the rat.

    Science.gov (United States)

    Northway, M G; Scobey, M W; Cassidy, K T; Geisinger, K R

    1990-12-01

    This study evaluated the effects of the nonsteroidal antiinflammatory agent piroxicam on chronic radiation proctitis in the rat. Forty female Wistar rats received a 2250-cGy dose of irradiation to the distal 2 cm of the colon. Twenty received piroxicam 8.0 mg/kg orally 30 minutes before exposure and 24 hours after exposure; 20 rats served as irradiated controls. All animals were evaluated by colonoscopy 1 and 3 weeks postexposure and every third week until death or killing at 1 year. At killing, colons were removed for light microscopic examination. One year postirradiation results showed no differences in mortality, vascular changes, acute inflammation, colitis cystica profunda, or rectal stricture between the control and piroxicam-treated groups. However, at 1 year postirradiation the control group demonstrated neoplasia in 15 of 19 animals compared with eight of 20 animals in the piroxicam-treated group. The first endoscopic appearance of colonic neoplasm occurred at 15 weeks postirradiation in one control irradiated rat whereas the first evidence of endoscopic neoplasm in the piroxicam-treated group did not occur until 36 weeks postirradiation. Histologic examination documented a tendency toward a greater presence of adenocarcinomas in the control group compared with the piroxicam-treated group. The authors conclude that piroxicam treatment significantly decreased the incidence of colonic neoplasia in general as well as delayed the endoscopic appearance of colonic neoplasia in rats after pelvic irradiation.

  13. Atención primaria: Una estrategia renovada

    OpenAIRE

    José A. Serna; Jaime Lee; Arnold Brommet

    2011-01-01

    Esta revisión profundiza en los cambios establecidos por diferentes estamentos mundiales con respecto al concepto ymodo de implementación de la estrategia de Atención Primaria en Salud (APS) originada en Alma-Ata en 1978. Bajacobertura, altos costos, inequidad, utilización inadecuada del talento humano y del recurso tecnológico hicieron imperiosasu actualización. En ella se establecen cuatro pilares fundamentales a introducir en sistemas de salud que tengan como su ejela APS, como el logro de...

  14. Factores asociados a tuberculosis multidrogorresistente primaria en pacientes de Callao, Perú

    Directory of Open Access Journals (Sweden)

    Ana Cecilia Avalos-Rodríguez

    2014-07-01

    Full Text Available Introducción: En el Perú, Lima y Callao constituyen regiones con riesgo alto de transmisión activa de tuberculosis. La tuberculosis multidrogorresistente se presenta en el 5,54% de los casos nuevos de tuberculosis pulmonar (TB MDR primaria en Lima y Callao. Sus factores de riesgo no han sido estudiados en pacientes del Callao. Objetivos: Determinar los factores de riesgo para TB MDR primaria en pacientes atendidos en centros de salud de Callao, durante los años 2009- 2010. Diseño: Estudio caso control. Lugar: Centros de Salud de Callao. Participantes: Participaron 29 pacientes con TB MDR primaria y 37 con tuberculosis sensible, según los registros del Programa de Control de Tuberculosis y las historias clínicas ubicadas en los centros de salud. Intervenciones: Toda la información fue obtenida de fuentes secundarias. En el análisis bivariado se calculó el OR de cada covariable. Para el cálculo de los OR multivariados se utilizó modelos de regresión logística. Principales medidas de resultados: Factores de riesgo para TB MDR. Resultados: En el análisis bivariado, el haber tenido contacto con pacientes TB MDR o XDR fue un factor de riesgo significativo (OR: 5,56; IC95%: 1,05 a 29,27; lo mismo se demostró en el análisis multivariado (OR: 14,56; IC95%: 1,52 a 139,54. Además, en el análisis multivariado, la variable edad ≥ 40 años mostró ser un factor protector significativo (OR: 0,94; IC95%: 0,90 a 0,99. Conclusiones: El tener contacto con pacientes TB MDR/XDR fue factor de riesgo y una edad menor a 40 años un factor protector para contraer TB MDR primaria en los pacientes del Callao estudiados.

  15. Systematic review with meta-analysis: the incidence of advanced neoplasia after polypectomy in patients with and without low-risk adenomas.

    Science.gov (United States)

    Hassan, C; Gimeno-García, A; Kalager, M; Spada, C; Zullo, A; Costamagna, G; Senore, C; Rex, D K; Quintero, E

    2014-05-01

    Patients with one to two tubular adenomas advanced neoplasia as those with no neoplasia at baseline colonoscopy. To compare incidence of metachronous advanced neoplasia between patients in the low-risk adenoma group and those without neoplasia at index colonoscopy. Relevant publications were identified by MEDLINE/EMBASE and other databases for the period 1992-2013. Studies comparing the incidence of post-polypectomy advanced neoplasia (adenomas ≥10 mm/high-grade dysplasia/villous or cancer) between the low-risk group and patients without colorectal neoplasia at the first colonoscopy were included. Detection rates for advanced neoplasia at endoscopic surveillance were extracted. Study quality was ascertained according to Newcastle-Ottawa Scale. Forest plot was produced based on random-effect models. Inter-study heterogeneity was assessed using the I(2) statistic. Seven studies provided data on 11 387 patients. Mean surveillance periods ranged between 2 and 5 years. Altogether, 267 patients with post-polypectomy advanced neoplasia were detected in the two groups. The incidence of advanced neoplasia was 1.6% (119/7308) in those without neoplasia and 3.6% (148/4079) in those with low-risk adenoma, respectively, corresponding to a relative risk of 1.8 (95% CI: 1.3-2.6). Inter-study heterogeneity was only moderate (I(2) : 37%). No publication bias was present. Patients with low-risk adenomas at baseline had a higher risk of metachronous advanced neoplasia than the group with no adenomas at baseline, though the absolute risk was low in both groups. © 2014 John Wiley & Sons Ltd.

  16. Endoscopic submucosal dissection for early Barrett’s neoplasia

    Science.gov (United States)

    Barret, Maximilien; Cao, Dalhia Thao; Beuvon, Frédéric; Leblanc, Sarah; Terris, Benoit; Camus, Marine; Coriat, Romain; Chaussade, Stanislas

    2015-01-01

    Introduction The possible benefit of endoscopic submucosal dissection (ESD) for early neoplasia arising in Barrett’s esophagus remains controversial. We aimed to assess the efficacy and safety of ESD for the treatment of early Barrett’s neoplasia. Methods All consecutive patients undergoing ESD for the resection of a visible lesion in a Barrett’s esophagus, either suspicious of submucosal infiltration or exceeding 10 mm in size, between February 2012 and January 2015 were prospectively included. The primary endpoint was the rate of curative resection of carcinoma, defined as histologically complete resection of adenocarcinomas without poor histoprognostic factors. Results Thirty-five patients (36 lesions) with a mean age of 66.2 ± 12 years, a mean ASA score of 2.1 ± 0.7, and a mean C4M6 Barrett’s segment were included. The mean procedure time was 191 ± 79 mn, and the mean size of the resected specimen was 51.3 ± 23 mm. En bloc resection rate was 89%. Lesions were 12 ± 15 mm in size, and 81% (29/36) were invasive adenocarcinomas, six of which with submucosal invasion. Although R0 resection of carcinoma was 72.4%, the curative resection rate was 66% (19/29). After a mean follow-up of 12.9 ± 9 months, 16 (45.7%) patients had required additional treatment, among whom nine underwent surgical resection, and seven further endoscopic treatments. Metachronous lesions or recurrence of cancer developed during the follow-up period in 17.2% of the patients. The overall complication rate was 16.7%, including 8.3% perforations, all conservatively managed, and no bleeding. The 30-day mortality was 0%. Conclusion In this early experience, ESD yielded a moderate curative resection rate in Barrett’s neoplasia. At present, improvements are needed if ESD is to replace piecemeal endoscopic mucosal resection in the management of Barrett’s neoplasia. PMID:27087948

  17. Panorama epidemiológico de la mortalidad por cáncer en el Instituto Mexicano del Seguro Social: 1991-1995 Epidemiologic panorama of cancer mortality in the Mexican Institute of Social Security: 1991-1995

    Directory of Open Access Journals (Sweden)

    JORGE SALMERÓN-CASTRO

    1997-07-01

    Full Text Available Objetivo. Describir el comportamiento de la mortalidad global por cáncer, así como la mortalidad específica para las principales neoplasias malignas en población adulta derechohabiente (DH del Instituto Mexicano del Seguro Social (IMSS. Material y métodos. A partir de los registros oficiales de defunción y de la información sobre la población para los años 1991-1995, se estimaron las tasas anuales de mortalidad global y específica para las 10 principales neoplasias malignas por sexo, en mayores de 20 años. Asimismo, se estimaron las tendencias nacionales y estatales para las principales neoplasias malignas para cada sexo por medio de regresión de Poisson. Se calcularon las diferencias de tasas de mortalidad específica para las dos principales neoplasias por sexo restando las tasas estatales a su respectiva tasa nacional en 1995. Resultados. La mortalidad global por cáncer en los hombres se incrementó de 76.2 en 1991, a 94.8 por 100 000 DH en 1995; entre las mujeres, ésta se incrementó de 85.6 a 105.8 por 100 000 DH, representando un incremento de 24.4 y de 24% en hombres y mujeres, respectivamente, durante el periodo de estudio. Entre los hombres las neoplasias de riñón, leucemia, páncreas, próstata y pulmón; y entre mujeres las de colon, mama, páncreas, leucemias e hígado, mostraron los incrementos más significativos. Conclusiones. En el IMSS es impostergable la conformación de un registro poblacional de cáncer que permita una mejor vigilancia epidemiológica de las neoplasias y una evaluación permanente del impacto de programas específicos para la prevención y control de este padecimiento en las instituciones.Objective. This paper describes the global cancer mortality and the specific mortality patterns for the main neoplasms among adult members of the Mexican Institute of Social Security (IMSS. Material and methods. Using official death certificates and information about the population of the IMSS members during

  18. Parathyroid mitogenic activity in plasma from patients with familial multiple endocrine neoplasia type 1

    International Nuclear Information System (INIS)

    Brandi, M.L.; Aurbach, G.D.; Fitzpatrick, L.A.; Quarto, R.; Spiegel, A.M.; Bliziotes, M.M.; Norton, J.A.; Doppman, J.L.; Marx, S.J.

    1986-01-01

    Hyperplasia of the parathyroid glands is a central feature of familial multiple endocrine neoplasia type 1. We used cultured bovine parathyroid cells to test for mitogenic activity in plasma from patients with this disorder. Normal plasma stimulated [ 3 H]thymidine incorporation, on the average, to the same extent as it was stimulated in a plasma-free control culture. This contrasted with the results of the tests with plasma from patients with familial multiple endocrine neoplasia type 1, in which parathyroid mitogenic activity increased 2400 percent over the control value (P less than 0.001). Plasma from these patients also stimulated the proliferation of bovine parathyroid cells in culture, whereas plasma from normal subjects inhibited it. Parathyroid mitogenic activity in plasma from the patients with familial multiple endocrine neoplasia type 1 was greater than that in plasma from patients with various other disorders, including sporadic primary hyperparathyroidism (with adenoma, hyperplasia, or cancer of the parathyroid), sporadic primary hypergastrinemia, sporadic pituitary tumor, familial hypocalciuric hypercalcemia, and multiple endocrine neoplasia type 2 (P less than 0.05). Parathyroid mitogenic activity in the plasma of patients with familial multiple endocrine neoplasia type 1 persisted for up to four years after total parathyroidectomy. The plasma also had far more mitogenic activity in cultures of parathyroid cells than did optimal concentrations of known growth factors or of any parathyroid secretagogue. This mitogenic activity had an apparent molecular weight of 50,000 to 55,000. We conclude that primary hyperparathyroidism in familial multiple endocrine neoplasia type 1 may have a humoral cause

  19. Ciberbullying en colegios privados y estatales de primaria en dos distritos de Lima Metropolitana

    Directory of Open Access Journals (Sweden)

    Isabel Amemiya

    2013-04-01

    Full Text Available Objetivos: Determinar las características del ciberbullying en escolares de 5° y 6° de primaria de colegios estatales y particulares, de Jesús María y Pueblo Libre. Diseño: Descriptivo transversal. Institución: Colegios estatales y particulares, de Jesús María y Pueblo Libre. Participantes: Alumnos de 5° y 6° de primaria. Intervenciones: En 826 alumnos de 5° y 6° de primaria, se aplicó una encuesta anónima de Rosario Ortega. Principales medidas de resultado: Análisis descriptivo y pruebas estadísticas de asociación. Resultados: Se comunicó ciberbullying en 24,7% de los alumnos; fue mayor en 6° grado y en colegios privados. La agresión por celular e internet ocurrió en 1,9% y hubo víctimas por celular en 6,3% y por internet 12%. La situación de victimas por internet se asoció a computadora en cuarto (p=0,019 y al uso de internet fuera de casa (p=0,000; fue mayor en colegios privados (p=0,002 y con el empleo de internet fuera de casa aumentó a 23,1% (p=0,032. Los varones agredieron más que las mujeres (p=0,000. Conclusiones: El ciberbullying fue más frecuente en alumnos de 6° de primaria de colegios privados. Las víctimas por internet fueron más frecuentes que por celular, y se asociaron a tener computadora en su cuarto o usarla fuera de casa. Predominó la agresión en los varones.

  20. PREVENCION PRIMARIA Y SECUNDARIA DE LA FRACTURA DE CADERA POR FRAGILIDAD ÓSEA EN LA POBLACIÓN DEL SECTOR SANITARIO TERUEL

    Directory of Open Access Journals (Sweden)

    Rafael Gómez Navarro

    2017-01-01

    Full Text Available La osteoporosis puede y debe prevenirse, diagnosticarse y tratarse, preferentemente antes de que aparezca la fractura por fragilidad. El objetivo fue analizar las intervenciones de prevención primaria y secundaria llevadas a cabo en las personas que sufrieron fractura de cadera por fragilidad en 2014 en el sector sanitario de Teruel. Método: Estudio descriptivo transversal. Variables analizadas: sexo, edad, zona básica de salud, residencia, situación funcional basal, antecedente de osteoporosis, fractura de fémur o vertebral, pérdida de estatura, utilización de FRAX, tratamiento al alta, exitus y su causa. Se empleó t- Student y ANOVA para variables cuantitativas por categorías y regresión para relaciones lineales. Resultados: Se incluyó a 148 personas, de las cuales 123 eran mujeres, con una mediana de edad de 87 años, 27,4% tenían dependencia grave o total para las actividades de la vida diaria, 33% estaban institucionalizados. El 10,1% tenían antecedente de fractura de cadera y 10% de fractura vertebral. Constaba diagnóstico de osteoporosis en el 13’7%. En ningún caso se había utilizado la herramienta FRAX®. Habían seguido tratamiento previo con calcio el 12,2%, con vitamina D el 11,5% y con fármacos antiosteoporóticos un 6,8%. Tras la fractura siguió tratamiento para prevención secundaria el 52,7%. A 31/12/2015 había fallecido un 25,7%, con mediana de supervivencia de los fallecidos de 64,5 días, siendo las causas de exitus más frecuentes enfermedad cardiovascular (42,3%, infección (23,1% y neoplasias (11,5%. Conclusiones: En nuestro sector sanitario es infrecuente la valoración de la osteoporosis y del riesgo de fractura en población de riesgo así como la indicación de medidas farmacológicas de prevención primaria. Aunque la indicación de terapia para la prevención secundaria es superior a la reflejada en la literatura, debemos tomar medidas adicionales para mejorar la prevención de fracturas por

  1. MAMMARY SOLID CARCINOMA WITH SPINAL CORD METASTASIS CARCINOMA SÓLIDO DE GLÂNDULA MAMÁRIA COM METÁSTASE EM MEDULA ESPINHAL

    Directory of Open Access Journals (Sweden)

    Denise Caroline Toledo

    2009-12-01

    Full Text Available

    Mammary neoplasias are common in canine females and carcinomas, among malignant types, occur frequently, especially solid form. At gross view, it can be small and incipient, but it’s invasive and show little differentiation, being able to produce metastasis that can compromise animal survive. This describes a bitch, Fila Brasileiro, six year old with tetraplegy and cervical spinal cord metastasis of mammary solid carcinoma.

    KEYWORDS: Central nervous system, dog, mammary neoplasia.

    Neoplasias mamárias são comuns entre as fêmeas caninas e os carcinomas, dentre as formas malignas, ocorrem com maior frequência, particularmente o tipo sólido. Estes podem apresentar-se pequenos e incipientes à macroscopia, contudo são invasivos e pouco diferenciados, com possibilidade de produzir metástases que comprometem a sobrevida do animal. Assim, descreve-se o caso de uma cadela, da raça Fila Brasileiro, de seis anos, que apresentou tetraplegia consequente à metástase medular cervical de carcinoma sólido mamário.

    PALAVRAS-CHAVES: Cão, neoplasia mamária, sistema nervoso central.

  2. Síndrome neuroléptica maligna: relato de caso com recorrência associada ao uso de olanzapina

    Directory of Open Access Journals (Sweden)

    HANEL RICARDO A.

    1998-01-01

    Full Text Available A síndrome neuroléptica maligna (SNM consiste em reação idiossincrática a neurolépticos, provavelmente relacionada a bloqueio dos receptores dopaminérgicos nos gânglios da base, sendo por isso também conhecida como síndrome da deficiência aguda de dopamina.A SNM é caracterizada por hiperpirexia, alteração do nível de consciência, hipertonia, disfunção autonômica e insuficiência respiratória, podendo ainda ser encontrados rabdomiólise e leucocitose. O haloperidol é a droga mais frequentemente associada à síndrome. Relatamos o caso de um paciente de 30 anos que apresentou SNM em duas ocasiões diferentes, a primeira delas relacionada ao uso de haloperidol e clorpromazina e a segunda relacionada ao uso de olanzapina, fato este sem menção anterior na literatura indexada.

  3. Alfabetización en salud en pacientes con insuficiencia cardiaca atendidos en atención primaria

    OpenAIRE

    Rosalia Santesmases-Masana; Luis González-de Paz; Jordi Real; Alicia Borràs-Santos; Antoni Sisó-Almirall; Maria Dolors Navarro-Rubio

    2017-01-01

    Objetivos: Examinar el nivel de alfabetización en salud y los factores que la condicionan en pacientes con insuficiencia cardiaca visitados en atención primaria. Diseño: Estudio transversal multicéntrico. Emplazamiento: Diez centros de atención primaria del área metropolitana de Barcelona. Participantes: Pacientes con diagnóstico de insuficiencia cardiaca. Criterios de inclusión: visita al centro de salud en el último año, desplazarse al centro de manera autónoma y acceder a particip...

  4. Anatomía Quirúrgica y Radiológica del Hígado. Fundamentos para las Resecciones Hepáticas

    OpenAIRE

    Manterola, Carlos; del-Sol, Mariano; Ottone, Nicolás; Otzen, Tamara

    2017-01-01

    RESUMEN: El hígado es un órgano sólido, de gran relevancia para la fisiología. Es asiento potencial de lesiones tumorales quísticas y sólidas; benignas y malignas (primarias y secundarias); razón por la cual, conocer su anatomía radiológica y quirúrgica es muy relevante. Los antecedentes históricos comienzan con Berta en 1716, quien fue el primero en realizar una resección hepática; en 1888, Lagenbuch fue el primero el realizar una resección hepática programada. En 1889, Keen realizó la prime...

  5. Validación de un modelo pronóstico para pacientes pluripatológicos en atención primaria: Estudio PROFUND en atención primaria

    Directory of Open Access Journals (Sweden)

    Pilar Bohórquez Colombo

    2014-06-01

    Conclusiones: el índice PROFUND mantiene una buena calibración reagrupado a tres estratos de riesgo, así como una buena precisión en el pronóstico a los dos años para poblaciones de pacientes pluripatológicos de atención primaria.

  6. Genetics Home Reference: X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia

    Science.gov (United States)

    ... Conditions XMEN X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia Printable PDF Open All Close ... boxes. Description X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia (typically known by the acronym ...

  7. Clinical significance of serum anti-human papillomavirus 16 and 18 antibodies in cervical neoplasia.

    Science.gov (United States)

    Chay, Doo Byung; Cho, Hanbyoul; Kim, Bo Wook; Kang, Eun Suk; Song, Eunseop; Kim, Jae-Hoon

    2013-02-01

    To estimate the clinical significance of serum anti-human papillomavirus (HPV) antibodies and high-risk cervical HPV DNA in cervical neoplasia. The study population comprised patients who were histopathologically diagnosed with cervical intraepithelial neoplasia (CIN) 1 (n=64), CIN 2 and 3 (n=241), cervical cancer (n=170), and normal control participants (n=975). Cervical HPV DNA tests were performed through nucleic acid hybridization assay tests, and serum anti-HPV 16 and 18 antibodies were measured by competitive immunoassay. The associations of HPV DNA and anti-HPV antibodies were evaluated with demographic characteristics and compared according to the levels of disease severity. Anti-HPV antibodies were also investigated with clinicopathologic parameters, including survival data. Among various demographic characteristics, factors involving sexual behavior had a higher tendency of HPV DNA positivity and HPV seropositivity. Human papillomavirus DNA mean titer and positivity were both increased in patients with cervical neoplasia compared with those with normal control participants, but there was no statistical difference among types of cervical neoplasia. Serum anti-HPV 16 antibodies were also able to differentiate cervical neoplasia from a normal control participant and furthermore distinguished CIN 1 from CIN 2 and 3 (odd ratio 2.87 [1.43-5.78], P=.002). In cervical cancer, HPV 16 seropositivity was associated with prolonged disease-free survival according to the univariable analysis (hazard ratio=0.12 [0.01-0.94], P=.044). Serum anti-HPV 16 antibodies can distinguish cervical neoplasia from a normal control and has the advantage of identifying high-grade CIN. Moreover, in cervical cancer, HPV 16 seropositivity may be associated with a more favorable prognosis. II.

  8. Piroxicam decreases postirradiation colonic neoplasia in the rat

    International Nuclear Information System (INIS)

    Northway, M.G.; Scobey, M.W.; Cassidy, K.T.; Geisinger, K.R.

    1990-01-01

    This study evaluated the effects of the nonsteroidal antiinflammatory agent piroxicam on chronic radiation proctitis in the rat. Forty female Wistar rats received a 2250-cGy dose of irradiation to the distal 2 cm of the colon. Twenty received piroxicam 8.0 mg/kg orally 30 minutes before exposure and 24 hours after exposure; 20 rats served as irradiated controls. All animals were evaluated by colonoscopy 1 and 3 weeks postexposure and every third week until death or killing at 1 year. At killing, colons were removed for light microscopic examination. One year postirradiation results showed no differences in mortality, vascular changes, acute inflammation, colitis cystica profunda, or rectal stricture between the control and piroxicam-treated groups. However, at 1 year postirradiation the control group demonstrated neoplasia in 15 of 19 animals compared with eight of 20 animals in the piroxicam-treated group. The first endoscopic appearance of colonic neoplasm occurred at 15 weeks postirradiation in one control irradiated rat whereas the first evidence of endoscopic neoplasm in the piroxicam-treated group did not occur until 36 weeks postirradiation. Histologic examination documented a tendency toward a greater presence of adenocarcinomas in the control group compared with the piroxicam-treated group. The authors conclude that piroxicam treatment significantly decreased the incidence of colonic neoplasia in general as well as delayed the endoscopic appearance of colonic neoplasia in rats after pelvic irradiation. 41 references

  9. Piroxicam decreases postirradiation colonic neoplasia in the rat

    Energy Technology Data Exchange (ETDEWEB)

    Northway, M.G.; Scobey, M.W.; Cassidy, K.T.; Geisinger, K.R. (Wake Forest Univ., Winston Salem, NC (USA))

    1990-12-01

    This study evaluated the effects of the nonsteroidal antiinflammatory agent piroxicam on chronic radiation proctitis in the rat. Forty female Wistar rats received a 2250-cGy dose of irradiation to the distal 2 cm of the colon. Twenty received piroxicam 8.0 mg/kg orally 30 minutes before exposure and 24 hours after exposure; 20 rats served as irradiated controls. All animals were evaluated by colonoscopy 1 and 3 weeks postexposure and every third week until death or killing at 1 year. At killing, colons were removed for light microscopic examination. One year postirradiation results showed no differences in mortality, vascular changes, acute inflammation, colitis cystica profunda, or rectal stricture between the control and piroxicam-treated groups. However, at 1 year postirradiation the control group demonstrated neoplasia in 15 of 19 animals compared with eight of 20 animals in the piroxicam-treated group. The first endoscopic appearance of colonic neoplasm occurred at 15 weeks postirradiation in one control irradiated rat whereas the first evidence of endoscopic neoplasm in the piroxicam-treated group did not occur until 36 weeks postirradiation. Histologic examination documented a tendency toward a greater presence of adenocarcinomas in the control group compared with the piroxicam-treated group. The authors conclude that piroxicam treatment significantly decreased the incidence of colonic neoplasia in general as well as delayed the endoscopic appearance of colonic neoplasia in rats after pelvic irradiation. 41 references.

  10. Estrategias y técnicas para desarrollar la expresión escrita en lengua inglesa en la etapa de Educación Primaria

    OpenAIRE

    Pellejero Torres, Gema

    2014-01-01

    En el presente trabajo se realiza una exposición acerca de la expresión escrita en inglés en Educación Primaria. Para ello analizamos su marco teórico, el currículum de primaria y varias estrategias y técnicas para el desarrollo de esta. Dada la importancia de la expresión escrita en el contexto escolar, hemos incluido una programación para poder fomentarla en la escuela. Grado en Educación Primaria

  11. Preliminary stop of the TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC) trial

    NARCIS (Netherlands)

    Koeneman, M. M.; Kruse, Arnold-Jan; Kooreman, L. F. S.; zur Hausen, Axel; Hopman, Anton H N; Sep, S. J. S.; Van Gorp, T.; Slangen, B. F. M.; van Beekhuizen, H. J.; de Sande, Michiel A. J. van; Gerestein, Cornelis G.; Nijman, H. W.; Kruitwagen, R. F. M. P.

    2017-01-01

    The "TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia" (TOPIC) trial was stopped preliminary, due to lagging inclusions. This study aimed to evaluate the treatment efficacy and clinical applicability of imiquimod 5% cream in high-grade cervical intraepithelial neoplasia

  12. Germ cell neoplasia in situ (GCNIS)

    DEFF Research Database (Denmark)

    Berney, Daniel M; Looijenga, Leendert H J; Idrees, Muhammad

    2016-01-01

    The pre-invasive lesion associated with post-pubertal malignant germ cell tumours of the testis was first recognized in the early 1970s and confirmed by a number of observational and follow-up studies. Until this year, this scientific story has been confused by resistance to the entity and disagr......The pre-invasive lesion associated with post-pubertal malignant germ cell tumours of the testis was first recognized in the early 1970s and confirmed by a number of observational and follow-up studies. Until this year, this scientific story has been confused by resistance to the entity...... and disagreement on its name. Initially termed 'carcinoma in situ' (CIS), it has also been known as 'intratubular germ cell neoplasia, unclassified' (IGCNU) and 'testicular intraepithelial neoplasia' (TIN). In this paper, we review the history of discovery and controversy concerning these names and introduce...

  13. Leiomiossarcoma de Mama: Relato de caso Leiomyosarcoma of the Breast: A Case Report

    Directory of Open Access Journals (Sweden)

    Juliane Oliveira de Assis

    2001-05-01

    Full Text Available Relatamos um caso de neoplasia maligna de mama com diagnóstico de leiomiossarcoma. Esta rara neoplasia tem comportamento biológico menos agressivo que outros tipos de sarcomas; por isso, chamamos atenção para o correto diagnóstico e a necessidade de graduação do neoplasma para seguimento da paciente, que, em nosso caso, com 2 anos de seguimento apresenta-se sem recidiva da doença.We report a malignant case of breast neoplasm, with the diagnosis of leiomyosarcoma. This rare neoplasm has a less aggressive biological behavior than the other types of breast sarcomas. That is the reason why we emphasize the correct diagnosis, and the necessity of graduating the neoplasm, for the patient's best follow-up. In our case, after 2 years of follow-up the patient continued with no relapse of the disease.

  14. Diagnóstico de febre catarral maligna em bovinos do Uruguai

    Directory of Open Access Journals (Sweden)

    Marcela Preliasco

    2013-01-01

    Full Text Available Foi realizado um estudo retrospectivo de 14 focos de febre catarral maligna (FCM em bovinos, detectados nos anos de 1999-2011, a partir dos arquivos da Seção Anatomia Patológica da Divisão de Laboratórios Veterinários (DILAVE "Miguel C. Rubino" Montevideo. Foram analisados os dados epidemiológicos, apresentação clínica e lesões macroscópicas e histopatológicas. Para a detecção do herpesvírus ovino tipo 2 (OvHV-2 foi utilizada a técnica de PCR sobre as amostras do sistema nervoso central de bovinos de 12 focos. Os surtos ocorreram principalmente nos meses de primavera e verão, na região norte do país. Em 64% (9/14 dos focos ocorreram episódios individuais da enfermidade, enquanto que os casos coletivos foram 5, nos quais a morbidade e mortalidade oscilaram entre 2% e 5%, sendo a letalidade 100% em todos os relatos. Em 50% dos surtos foi confirmado o contato direto entre bovinos e ovinos, enquanto no restante não havia tal informação. Clinicamente predominaram os sinais de opacidade bilateral da córnea, conjuntivite, secreção nasal e ocular mucopurulenta, assim como a síndrome nervosa. Os achados de necropsia mais frequentes foram opacidade bilateral da córnea e lesões inflamatórias nas mucosas. Os achados histopatológicos caracterizaram-se por panvasculite necrótica sistêmica. Foi possível detectar o agente etiológico por PCR em 5 dos 12 casos analisados.

  15. Proyecto de creatividad literaria en el aula de Primaria

    OpenAIRE

    Bellota Miguel, Ibone

    2014-01-01

    Desarrollar en los niños la creatividad literaria a través de los cuentos, de una forma amena y divertida. El cuento usado como instrumento didáctico para aprender y para ayudar al niño a adquirir distintos valores que luego podrán utilizar en aspectos de su vida cotidiana. Fomentar la lectura a través de los cuentos. Grado en Educación Primaria

  16. Incentivos en atención primaria: de la contención del gasto a la salud de la población

    OpenAIRE

    Gérvas Camacho, Juan Javier; Ortún Rubio, Vicente; Palomo Cobos, Luis; Ripoll, Miguel Ángel

    2007-01-01

    Este texto se elaboró a partir del debate en el segundo taller presencial de los Seminarios de Innovación en Atención Primaria, que en 2007 se dedican a la organización de los servicios en atención primaria. Se celebró en Madrid, el 22 de junio de 2007, y fue ponente Vicente Ortún, contrapuntos Luis Palomo y Miguel Ángel Ripoll, y coordinador Juan Gérvas. Los Seminarios de Innovación en Atención Primaria están organizados por la Fundación Ciencias de la Salud y la Fundación para la Formación ...

  17. Inmunología tumoral y neoplasias del sistema inmune

    OpenAIRE

    Sen Fernández, María Luz de la; Sempere Ortells, José Miguel; Marco, Francisco M.; Vázquez Araujo, Begoña

    2012-01-01

    Inmunología tumoral: vigilancia inmunológica, antígenos tumorales, respuesta inmune antitumoral, escape tumoral. Inmunología y diagnóstico. Inmunoterapia. Neoplasias del sistema inmune: leucemias y linfomas.

  18. Síntese e caracterização de nanoestruturas de sílica SBA -16 contendo gadolinio-159 como potencial sistema nanoparticulado para o tratamento do câncer

    OpenAIRE

    André Felipe de Oliveira

    2013-01-01

    O câncer é uma das principais causas de morte em todo o mundo, sendo as neoplasias malignas de pulmão, estômago, fígado, cólon e mama em maior número. E, recentemente, observa-se na literatura um grande número de trabalhos onde novos materiais, especialmente nanoparticulados, vêm sendo estudados como carreadores de drogas e radioisótopos aplicados ao tratamento do câncer. Como materiais mesoporosos à base de sílica, graças a sua enorme área superficial e biocompatibilidade, têm sido estudados...

  19. Metástasis en hueso maxilar superior de adenocarcinoma de esófago: presentación de un caso clínico

    OpenAIRE

    Sánchez Jiménez, Juan; Acebal Blanco, Faustino; Arévalo Arévalo, Rafael; Molina Martínez, Manuel

    2005-01-01

    Las metástasis en cavidad oral son lesiones raras que representan aproximadamente el 1% de todas las neoplasias malignas de cavidad oral. Las metástasis orales se localizan en un 80-90% en mandíbula, siendo mas raras en maxilar superior. Las metástasis en tejidos blandos de boca son raras, y es encía donde con mayor frecuencia se localizan las metástasis en tejidos blandos en boca. Los tumores primarios que metastatizan a boca son los más frecuentes pulmón, mama y riñón. ...

  20. Neumotórax bilateral como complicación de metástasis pulmonar cavitaria de un angiosarcoma

    Directory of Open Access Journals (Sweden)

    Lorena V. Maldonado

    2014-06-01

    Full Text Available Las metástasis pulmonares de angiosarcoma constituyen una complicación común de una neoplasia maligna poco frecuente. Habitualmente se presentan como nódulos solidos periféricos y derrame pleural. Presentamos el caso de un hombre de 65 años de edad con neumotórax bilateral recurrente, secundario a metástasis cavitadas de un angiosarcoma primitivo de cuero cabelludo. La videotoracoscopia permitió la inspección, la resección de las metástasis y la pleurodesis. No ocurrieron complicaciones ni recurrencia tumoral a los seis meses de seguimiento.

  1. Carcinoma inflamatório mamário canino.

    OpenAIRE

    Gomes, Cristiano; Voll, Juliana; Ferreira, Kelly; Ferreira, Rafael Rodrigues; Oliveira, Luciana Oliveira de; Contesini, Emerson Antônio; Oliveira, Rosemari Teresinha de

    2006-01-01

    O carcinoma inflamatório mamário é um carcinoma anaplásico com características clínicas e histopatológicas como crescimento rápido, envolvimento difuso, eritema, calor e dor nas mamas, edema nos membros posteriores, extensa infiltração de células inflamatórias, células epiteliais malignas nos linfonodos regionais apresentando um péssimo prognóstico. O cão é a única espécie animal em que esta neoplasia ocorre espontaneamente, entretanto apresenta uma incidência bastante rara tanto em humanos q...

  2. Influencia del rechazo escolar sobre la alta ansiedad ante el castigo escolar en educación primaria

    Directory of Open Access Journals (Sweden)

    María Isabel Gómez-Núñez

    2017-12-01

    Full Text Available El objetivo de este estudio consistió en analizar la capacidad predictiva del rechazo escolar sobre los altos niveles de ansiedad ante el castigo escolar (ACE. Para ello, se reclutó una muestra de 1,003 estudiantes de Educación Primaria con edades comprendidas entre los 8 y los 12 años. Los instrumentos empleados fueron el Inventario de Ansiedad Escolar para Educación Primaria (IAEP y el School Refusal Assessment Scale-Revised for Children (SRAS-R-C. Los resultados del análisis de regresión logística revelaron que el rechazo escolar para evitar estímulos que provocan emociones negativas actuaba como una variable predictora estadísticamente significativa de la ACE en la muestra total, en las muestras por sexo (chicos y chicas y en las muestras por curso académico (3.°, 4.°, 5.° y 6.° de Educación Primaria. Por otro lado, el rechazo escolar para evitar situaciones sociales aversivas y/o de evaluación y el rechazo escolar para llamar la atención influían positivamente sobre la alta ACE en la muestra de chicos y en 4.° de Educación Primaria, respectivamente. Estos resultados muestran la importancia de valorar el rechazo escolar, por la influencia que podría ejercer en la aparición de altos niveles de ansiedad ante el castigo escolar.

  3. Aspectos de posesión, permisos y usos educativos de dispositivos portátiles durante el trayecto de primaria a universidad

    Directory of Open Access Journals (Sweden)

    Javier Organista Sandoval

    2014-10-01

    Full Text Available Se presentan los principales resultados de una investigación cuyo propósito es explorar el nivel de posesión de teléfono celular de los estudiantes de primaria, secundaria, preparatoria y universidad de la zona urbana de Ensenada, México. Se analiza el contexto de permisos y prohibiciones del uso del teléfono celular en las escuelas y en qué medida el docente implementa estrategias pedagógicas para su uso. Se desarrolló y aplicó una encuesta a 2 635 estudiantes de los cuatro niveles educativos mencionados. La posesión de teléfono celular presenta una tendencia ascendente según el nivel educativo. Mientras que en primaria el porcentaje de posesión llega a 58%, en universidad alcanza 97%. Por su parte, la tableta encuentra su máximo porcentaje de posesión (46% en el nivel primaria. Llama la atención que la edad en que el estudiante de primaria comienza a usar el teléfono celular es a los 7.8 años. El teléfono celular se ubica en un contexto escolar de prohibición en los niveles primaria y secundaria; sin embargo, en preparatoria y universidad es incipiente su uso con propósito educativo. El potencial pedagógico del teléfono celular es enorme, pero requiere una nueva visión del proceso educativo.

  4. Las representaciones sociales sobre Derechos Humanos en niños de primaria

    Directory of Open Access Journals (Sweden)

    Germán Flores Martínez

    2015-08-01

    Full Text Available La presente investigación tuvo como objetivo principal la exploración y descripción de las representaciones sociales que los niños de educación primaria de quinto grado manifiestan sobre los Derechos Humanos. El estudio, realizado desde un enfoque cualitativo, se llevó a cabo en la Escuela Primaria Rural Emiliano Zapata, de la comunidad de Xochiteotla, Chiutempan, Tlaxcala (México. La población del estudio está conformada por 26 alumnos entre los 11 y 12 años. Los resultados obtenidos demuestran que los niños tienen una visión de los Derechos Humanos construida desde su contexto, y materializada en personas que cumplen con una función social. También los derechos humanos se materializan en objetos y en situaciones de su realidad; tanto en su lenguaje, como en su representación gráfica.

  5. Impacto de una intervención informativa sobre el programa de cribado de cáncer colorrectal en profesionales de atención primaria

    OpenAIRE

    Benito-Aracil, Llúcia; Binefa, Gemma; Milà, Núria; Lluch Canut, Ma. Teresa; Puig Llobet, Montserrat; García Martínez, Montserrat

    2015-01-01

    Objetivo: Evaluar el impacto de una intervención informativa a profesionales de atención pri-maria sobre sus conocimientos de cribado de cáncer colorrectal, recomendaciones de vigilanciaposterior y estrategias de derivación. Método diseÑo: Ensayo clínico controlado y aleatorizado por conglomerados. Emplazamiento:centros de atención primaria de L'Hospitalet de Llobregat (Barcelona). Participantes: médi-cos y enfermeras de atención primaria. Intervención: sesión informativa y envío de píldorasi...

  6. La creatividad musical y las emociones. Tdah o trastorno de déficit de atención con hiperactividad en el aula de Primaria

    OpenAIRE

    Ruiz Hernández, Cristina

    2016-01-01

    Con este trabajo el problema de un TDAH y posibles problemas psicológicos serán investigados por medio de la creatividad musical y de las emociones utilizando la música en la Educación Primaria. Además con el estudio y la investigación de la enseñanza de la música, se intentará animarlos a expresar emociones y a tener creatividad para evitar problemas de comportamiento psicológicos que se dan en la etapa de Primaria. Grado en Educación Primaria

  7. Características de um grupo de adolescentes com suspeita de neoplasia intra-epitelial cervical Characteristics of a group of adolescents with suspected cervical intraepithelial neoplasia

    Directory of Open Access Journals (Sweden)

    Maria Isabel do Nascimento

    2005-10-01

    Full Text Available OBJETIVO: avaliar a prevalência de alterações citológicas, colposcópicas e histopatológicas observadas no colo uterino de adolescentes com suspeita de neoplasia cervical e as correlações epidemiológicas, compararando com mulheres adultas jovens. MÉTODOS: estudo transversal, retrospectivo de revisão de 366 prontuários de mulheres encaminhadas para esclarecimento diagnóstico com suspeita de neoplasia cervical. As pacientes foram classificadas em dois grupos definidos por idade. O grupo Adolescente foi composto por 129 mulheres de 13 a 19 anos e o grupo Adulta foi composto por 237 mulheres de 20 a 24 anos. Foram calculados razão de prevalência (RP, respectivos intervalos de confiança (IC a 95% para cada variável, teste chi2 ou teste exato de Fisher quando aplicável para comparação das proporções. RESULTADOS: a sexarca ocorreu em média aos 15,0 anos no grupo Adolescente e 16,6 anos no grupo Adulta. A chance de diagnóstico de alterações citológicas no primeiro exame realizado (RP=2,61; IC 95%: 2,0-3,4, a condição neoplasia intra-epitelial cervical (NIC a esclarecer (RP=1,78; IC 95%: 1,26-2,52 e a colposcopia de baixo grau (RP=1,42; IC 95%: 1,08-1,86 foram estatisticamente significantes no grupo Adolescente. A análise histopatológica não mostrou diferenças para qualquer grau de NIC. Entretanto, foram identificados dois casos de carcinoma microinvasor, sendo um em cada grupo, e três casos de carcinoma invasor no grupo Adulta. CONCLUSÃO: nosso estudo sugere que o câncer de colo uterino é raro na adolescência, mas verificamos que alterações a ele associadas aconteceram em mulheres muito jovens. A investigação da neoplasia intra-epitelial cervical com a aplicação criteriosa dos mesmos métodos utilizados para a mulher adulta foi apropriada também na adolescência.PURPOSE: to evaluate the prevalence of cytologic, colposcopic and histopathologic alterations observed in the uterine cervix of adolescents with

  8. Detection of Human Papillomavirus Infection in Patients with Vaginal Intraepithelial Neoplasia.

    Science.gov (United States)

    Lamos, Cristina; Mihaljevic, Charlotte; Aulmann, Sebastian; Bruckner, Thomas; Domschke, Christoph; Wallwiener, Markus; Paringer, Carmen; Fluhr, Herbert; Schott, Sarah; Dinkic, Christine; Brucker, Janina; Golatta, Michael; Gensthaler, Lisa; Eichbaum, Michael; Sohn, Christof; Rom, Joachim

    2016-01-01

    Vaginal intraepithelial neoplasia (VAIN) is a pre-malignant lesion, potentially leading to vaginal cancer. It is a rare disease, representing less than 1% of all intraepithelial neoplasia of the female genital tract. Similar to cervical intraepithelial neoplasia (CIN), there are three different grades of VAIN. VAIN 1 is also known as a low-grade squamous intraepithelial lesion (LSIL), whereas VAIN 2 and VAIN 3 both represent high-grade squamous intraepithelial lesions (HSIL). Risk factors for the development of VAIN are similar to those for cervical neoplasia, i.e. promiscuity, starting sexual activity at an early age, tobacco consumption and infection with human papillomavirus (HPV). However, compared to other intraepithelial neoplasia such as CIN or VIN (vulvar intraepithelial neoplasia), there still is little understanding about the natural course of VAIN and its capacity for pro- or regression. Furthermore, there is controversial data about the HPV detection rate in VAIN lesions. 67 patients with histologically confirmed VAIN, who were diagnosed between 2003 and 2011 at the University Women´s Hospital of Heidelberg Germany, were included in this study. The biopsies of all participating patients were subjected to HPV genotyping. GP-E6/E7 Nested Multiplex PCR (NMPCR) was used to identify and genotype HPV. Eighteen pairs of type-specific nested PCR primers were assessed to detect the following "high-risk" HPV genotypes: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68, as well as the "low-risk" genotypes 6/11, 42, 43 and 44. The data was analyzed with the software SAS (Statistical Analysis System). All 67 cases were eligible for DNA analysis. The median age was 53 years. The largest group with 53% (n = 36) was formed by women, who were first diagnosed with VAIN between the age of 41 to 60 years. 50% (n = 37) of the patients presented a VAIN in the upper 1/3 of the vagina. 58 (87%) were diagnosed with HSIL (VAIN). The median age in patients with LSIL

  9. 2015. 2. Por qué celebrar primarias

    OpenAIRE

    Sanz Díaz, Benito

    2015-01-01

    ¿Por qué celebrar primarias? ¿Beneficia o perjudica a las organizaciones y partidos que las promueven?, ¿Mejora la participación?, ¿La elección de los dirigentes evita la oligarquización y la Ley de Hierro de los partidos políticos que enunció Robert Michels? Un sistema de selección de candidatos con origen en la política norteamericana, fue adaptado por el PSOE, y a continuación iría extendiéndose su práctica a los todos los partidos políticos. Ignacio Urquizu señalaba sobre l...

  10. Investigating work-related neoplasia associated with solar radiation.

    Science.gov (United States)

    Turner, S; Forman, S D; McNamee, R; Wilkinson, S M; Agius, R

    2015-01-01

    Both solar and non-solar exposures associated with occupation and work tasks have been reported as skin carcinogens. In the UK, there are well-established surveillance schemes providing relevant information, including when exposures took place, occupation, location of work and dates of symptom onset and diagnosis. To add to the evidence on work-related skin neoplasia, including causal agents, geographical exposure and time lag between exposure and diagnosis. This study investigated incident case reports of occupational skin disease originating from clinical specialists in dermatology reporting to a UK-wide surveillance scheme (EPIDERM) by analysing case reports of skin neoplasia from 1996 to 2012 in terms of diagnosis, employment, suspected causal agent and symptom onset. The suspected causal agent was 'sun/sunlight/ultraviolet light' in 99% of the reported work-related skin neoplasia cases. Most cases reported (91%) were in males, and the majority (62%) were aged over 65 at the time of reporting. More detailed information on exposure was available for 42% of the cases, with the median time from exposure to symptom onset ranging from 44 (melanoma) to 57 (squamous cell carcinoma) years. Irrespective of diagnostic category, the median duration of exposure to 'sun/sunlight/ultraviolet light' appeared longer where exposures occurred in the UK (range 39-51 years) rather than outside the UK (range 2.5-6.5 years). It is important to provide effective information about skin protection to workers exposed to solar radiation, especially to outdoor workers based outside the UK. © The Author 2014. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  11. ALTERAÇÕES NO HEMOGRAMA DE CADELAS COM NEOPLASIA MAMÁRIA

    OpenAIRE

    Antonio Henrique Cereda da Silva; Daniella Matos da Silva; Cristina Rauen Ribas; Rosangela Locatelli Dittrich; Peterson Triches Dornbusch; Simone Domit Guérios

    2014-01-01

    As alterações no hemograma estão direta ou indiretamente relacionadas com câncer e são pouco descritas em cadelas com neoplasia mamária. O objetivo deste estudo foi analisar as alterações hematológicas em 161 cadelas portadoras de neoplasia mamária e correlacionar à progressão da doença. As principais alterações hematológicas encontradas foram anemia normocítica e normocrômica e leucocitose neutrofílica, sendo ambas mais frequentes em cadelas em estádio avançado (III, IV ou V) da doença. Conc...

  12. Transporter function and cyclic AMP turnover in normal colonic mucosa from patients with and without colorectal neoplasia

    Directory of Open Access Journals (Sweden)

    Kleberg Karen

    2012-06-01

    Full Text Available Abstract Background The pathogenesis of colorectal neoplasia is still unresolved but has been associated with alterations in epithelial clearance of xenobiotics and metabolic waste products. The aim of this study was to functionally characterize the transport of cyclic nucleotides in colonic biopsies from patients with and without colorectal neoplasia. Methods Cyclic nucleotides were used as model substrates shared by some OATP- and ABC-transporters, which in part are responsible for clearance of metabolites and xenobiotics from the colonic epithelium. On colonic biopsies from patients with and without colorectal neoplasia, molecular transport was electrophysiologically registered in Ussing-chamber set-ups, mRNA level of selected transporters was quantified by rt-PCR, and subcellular location of transporters was determined by immunohistochemistry. Results Of four cyclic nucleotides, dibuturyl-cAMP induced the largest short circuit current in both patient groups. The induced short circuit current was significantly lower in neoplasia-patients (p = 0.024. The observed altered transport of dibuturyl-cAMP in neoplasia-patients could not be directly translated to an observed increased mRNA expression of OATP4A1 and OATP2B1 in neoplasia patients. All other examined transporters were expressed to similar extents in both patient groups. Conclusions OATP1C1, OATP4A1, OATP4C1 seem to be involved in the excretory system of human colon. ABCC4 is likely to be involved from an endoplasmic-Golgi complex and basolateral location in goblet cells. ABCC5 might be directly involved in the turnover of intracellular cAMP at the basolateral membrane of columnar epithelial cells, while OATP2B1 is indirectly related to the excretory system. Colorectal neoplasia is associated with lower transport or sensitivity to cyclic nucleotides and increased expression of OATP2B1 and OATP4A1 transporters, known to transport PGE2.

  13. Stop-motion para la alfabetización digital en Educación Primaria

    Directory of Open Access Journals (Sweden)

    2017-04-01

    Full Text Available A pesar de que la alfabetización digital en medios se reconoce como una de las competencias esenciales necesarias para vivir en una nueva era de los medios de comunicación, solo acaba de empezar a ganar atención en la educación primaria de Taiwán. Una de las razones es la educación orientada a los exámenes, y como consecuencia, el que se desvíe muy pocos recursos para este aprendizaje informal. La otra razón es que los educadores tienden a pensar en la educación en medios digitales como una serie de operaciones puramente técnicas, lo que podría llevar a los estudiantes de medios digitales a aprender a trabajar sin sentido. Por lo tanto, este estudio diseñó una exhibición de contenidos basada en el modelo de aprendizaje experiencial de Kolb con el fin de enseñar a los estudiantes conceptos de videos stop-motion y técnicas de producción cinematográfica. El experimento diseñado involucró a 247 estudiantes de tercer grado de primaria que fueron agrupados para visitar la exposición experiencial. Los hallazgos sugieren una mejora en los estudiantes de su conocimiento de videos stop-motion. El análisis de los vídeos producidos también muestra que han mejorado su capacidad mediática para representar sus ideas y comunicarse con los demás. A través del análisis de la influencia de la demografía en la prueba de conocimiento, los hallazgos revelan que la exposición experiencial es más efectiva para los estudiantes de primaria femeninos, y que las experiencias anteriores relevantes de los estudiantes no deberían afectar a los conocimientos adquiridos. Teniendo en cuenta estos resultados y observaciones, creemos que la exposición experimental propuesta es una forma prometedora de llevar a cabo la educación en alfabetización digital en las escuelas primarias.

  14. Deporte, periodismo y lengua. Propuesta didáctica para 1º curso de Educación Primaria.

    OpenAIRE

    Martínez Medina, Adrián

    2017-01-01

    El deporte y los medios de comunicación son un atractivo para el alumnado. Este trabajo revisa qué dicen distintos autores sobre estos dos temas para justificar el uso del periódico y las noticias deportivas en el aula de Primaria. Además, se incluye una propuesta de intervención para el área de Lengua Castellana y Literatura diseñada a partir de la realización de un cuestionario realizado al alumnado de 1º curso de Educación Primaria del centro educativo “Fuente del Rey” sobre sus gustos y a...

  15. El juego como recurso de enseñanza de la Educación Músical en la Escuela Primaria

    OpenAIRE

    Warncke Monsalve, Natalia

    2017-01-01

    A través de la Educación Musical en la etapa de Educación Primaria el alumnado desarrolla todos los ámbitos del ser humano: físico, social, cognitivo y emocional. Como maestros de música, podemos usar diversos métodos y numerosos recursos, como los juegos, no solo para conseguir el aprendizaje de los contenidos recogidos en el currículum sino para lograr su educación integral. En este trabajo, realizamos una propuesta, destinada para 4º de Educación Primaria, que recoge la e...

  16. RELANZAMIENTO ATENCIÓN PRIMARIA EN SALUD

    Directory of Open Access Journals (Sweden)

    Gustavo Malagón Londoño

    2011-04-01

    Full Text Available

    Con la memorable sesión, en el auditorio de la Academia Nacional de Medicina, ante autoridades de la salud, miembros del cuerpo docente de las universidades, representantes de las sociedades científicas y académicos, la Directora General de la Organización Panamericana de la Salud, Doctora Mirta Roses Periago, hizo el solemne relanzamiento de la Atención Primaria de Salud en las Américas, como una nueva estrategia renovada, probada a merced de numerosas experiencias y sometida a los más variados debates durante los 33 años transcurridos desde Alma Ata en 1978, cuando se invocó como la estrategia fundamental para el objetivo de “Salud para todos”.

    Cabe recordar que a raíz de la promulgación en 1978, se tejieron toda clase de versiones alrededor del significado de la estrategia planteada entonces como un paso fundamental, para un objetivo que parecía inalcanzable. En numerosos debates se hablaba de que se presentaba como una atención elemental de salud, en otros se situaba como el primer contacto de la población con la entidad de salud, en el mejor de los casos se le daba el significado de primera atención, en algunos de atención primordial, en otros de atención básica, no pocos la asimilaban a salud familiar, finalmente cuando se habló en Otawa (Canadá 1986 de la promoción y prevención como fuerzas insustituibles y el Director de la Organización Mundial de la Salud (Mahler 1986 habló de la “reacción favorable frente al fracaso de las acciones anteriores”, tomó fuerza el concepto de atención primaria como el motor insustituible para la promoción y prevención.

  17. Estudio de caso de maestra transexual: la transexualidad como ejemplo de diversidad afectivo-sexual en Educación Primaria

    OpenAIRE

    Parra Rodríguez, Fátima

    2017-01-01

    El siguiente trabajo «Estudio de caso de maestra transexual: la transexualidad como ejemplo de diversidad afectivo-sexual en Educación Primaria» pretende ser una evidencia de la diversidad afectivo-sexual presente en la escuela como institución que configura y constituye la sociedad. El objeto de estudio es una de las pocas maestras transexuales ejerciendo actualmente en la Educación Primaria andaluza. El testimonio sobre su experiencia personal en el ámbito privado, activista y educativo se ...

  18. Chlamydia trachomatis infection and risk of cervical intraepithelial neoplasia

    DEFF Research Database (Denmark)

    Lehtinen, Matti; Ault, Kevin A; Lyytikainen, Erika

    2011-01-01

    High-risk human papillomavirus (hrHPV) is the primary cause of cervical cancer. As Chlamydia trachomatis is also linked to cervical cancer, its role as a potential co-factor in the development of cervical intraepithelial neoplasia (CIN) grade 2 or higher was examined....

  19. Tobacco, alcohol, and p53 overexpression in early colorectal neoplasia

    International Nuclear Information System (INIS)

    Terry, Mary Beth; Neugut, Alfred I; Mansukhani, Mahesh; Waye, Jerome; Harpaz, Noam; Hibshoosh, Hanina

    2003-01-01

    The p53 tumor suppressor gene is commonly mutated in colorectal cancer. While the effect of p53 mutations on colorectal cancer prognosis has been heavily studied, less is known about how epidemiologic risk factors relate to p53 status, particularly in early colorectal neoplasia prior to clinically invasive colorectal cancer (including adenomas, carcinoma in situ (CIS), and intramucosal carcinoma). We examined p53 status, as measured by protein overexpression, in 157 cases with early colorectal neoplasia selected from three New York City colonoscopy clinics. After collecting paraffin-embedded tissue blocks, immunohistochemistry was performed using an anti-p53 monoclonal mouse IgG 2 a [BP53-12-1] antibody. We analyzed whether p53 status was different for risk factors for colorectal neoplasia relative to a polyp-free control group (n = 508). p53 overexpression was found in 10.3%, 21.7%, and 34.9%, of adenomatous polyps, CIS, and intramucosal cases, respectively. Over 90% of the tumors with p53 overexpression were located in the distal colon and rectum. Heavy cigarette smoking (30+ years) was associated with cases not overexpressing p53 (OR = 1.8, 95% CI = 1.1–2.9) but not with those cases overexpressing p53 (OR = 1.0, 95% CI = 0.4–2.6). Heavy beer consumption (8+ bottles per week) was associated with cases overexpressing p53 (OR = 4.0, 95% CI = 1.3–12.0) but not with cases without p53 overexpression (OR = 1.6, 95% CI = 0.7–3.7). Our findings that p53 overexpression in early colorectal neoplasia may be positively associated with alcohol intake and inversely associated with cigarette smoking are consistent with those of several studies of p53 expression and invasive cancer, and suggest that there may be relationships of smoking and alcohol with p53 early in the adenoma to carcinoma sequence

  20. Male pattern baldness and risk of colorectal neoplasia.

    Science.gov (United States)

    Keum, N; Cao, Y; Lee, D H; Park, S M; Rosner, B; Fuchs, C S; Wu, K; Giovannucci, E L

    2016-01-12

    Male pattern baldness is positively associated with androgens as well as insulin-like growth factor 1 (IGF-1) and insulin, all of which are implicated in pathogenesis of colorectal neoplasia. From 1992 through 2010, we prospectively followed participants in the Health Professionals Follow-Up Study. Hair pattern at age 45 years was assessed at baseline with five image categories (no baldness, frontal-only baldness, frontal-plus-mild-vertex baldness, frontal-plus-moderate-vertex baldness, and frontal-plus-severe-vertex baldness). Cancer analysis included 32 782 men and used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Restricted to men who underwent at least one endoscopy over the study period, adenoma analysis included 29 770 men and used logistic regressions for clustered data to estimate odds ratios (ORs) and 95% CIs. Over the mean follow-up of 15.6 years, 710 cases of colorectal cancer (478 for colon, 152 for rectum, and 80 unknown site) developed. Significantly increased risks associated with frontal-only baldness and frontal-plus-mild-vertex baldness relative to no baldness were observed for colon cancer with respective HR being 1.29 (95% CI, 1.03-1.62) and 1.31 (95% CI, 1.01-1.70). Over the 19-year study period, 3526 cases of colorectal adenoma were detected. Evidence for an increased risk of colorectal adenoma relative to no baldness was significant with frontal-only baldness (OR, 1.16; 95% CI, 1.06-1.26) and borderline insignificant with frontal-plus-severe-vertex baldness (OR, 1.14; 95% CI, 0.98-1.33). Subtypes of male pattern baldness at age 45 years were positively associated with colorectal neoplasia. Future studies are warranted to confirm our results and to determine the predictive value of male pattern baldness to identify those at high risk for colorectal neoplasia.

  1. Cold-knife and laser conization for cervical intraepithelial neoplasia

    DEFF Research Database (Denmark)

    Tabor, A; Berget, A

    1990-01-01

    In a 5-year study, 425 women had conization performed for cervical intraepithelial neoplasia (CIN) I, II or III. Conization was performed only in cases of positive endocervical curettage or when colposcopy was inconclusive. In all other cases, local destruction was the operation of choice...

  2. ¿Cómo podemos aprender el arte en Educación Primaria? ¡Traslademos las obras de arte al aula!

    OpenAIRE

    Feliu Torruella, María

    2011-01-01

    Con este artículo pretendemos mostrar una experiencia de investigación en el aula de primaria en seis centros educativos. Dónde se han experimentado dos unidades didácticas con metodologías diferentes para verificar la incidencia de los métodos en los procesos de enseñanza y aprendizaje del arte. Palabras clave: investigación, didáctica del arte, educación primaria, metodología enseñanza.

  3. Anti-topoisomerase drugs as potent inducers of chromosomal aberrations

    Directory of Open Access Journals (Sweden)

    Loredana Bassi

    2000-12-01

    Full Text Available DNA topoisomerases catalyze topological changes in DNA that are essential for normal cell cycle progression and therefore they are a preferential target for the development of anticancer drugs. Anti-topoisomerase drugs can be divided into two main classes: "cleavable complex" poisons and catalytic inhibitors. The "cleavable complex" poisons are very effective as anticancer drugs but are also potent inducers of chromosome aberrations so they can cause secondary malignancies. Catalytic inhibitors are cytotoxic but they do not induce chromosome aberrations. Knowledge about the mechanism of action of topoisomerase inhibitors is important to determine the best anti-topoisomerase combinations, with a reduced risk of induction of secondary malignancies.As topoisomerases de DNA catalisam alterações topológicas no DNA que são essenciais para a progressão do ciclo celular normal e, portanto, são um alvo preferencial para o desenvolvimento de drogas anticâncer. Drogas anti-topoisomerases podem ser divididas em duas classes principais: drogas anti-"complexos cliváveis" e inibidores catalíticos. As drogas anti-"complexos cliváveis" são muito eficazes como drogas anticancerígenas, mas são também potentes indutores de aberrações cromossômicas, podendo causar neoplasias malignas secundárias. Inibidores catalíticos são citotóxicos mas não induzem aberrações cromossômicas. Conhecimento a respeito do mecanismo de ação de inibidores de topoisomerases é importante para determinar as melhores combinações anti-topoisomerases, com um reduzido risco de indução de neoplasias malignas secundárias.

  4. IMPLEMENTACION DE UNA CENTRAL DE COORDINACION COMO MEDIDA DE MEJORA AL SISTEMA DE ATENCION PRIMARIA DE SALUD

    OpenAIRE

    BAZAN GANTZ, OSCAR ANDRES; BAZAN GANTZ, OSCAR ANDRES

    2012-01-01

    La salud pública chilena, es uno de los servicios públicos con mayor utilización, y a la vez, obtiene, por parte de los usuarios, los peores resultados en la medición de percepción de la calidad de la atención.(Subjetiva, 2010) La atención primaria de salud (APS) es la puerta de entrada al sistema, contando con una altísima cobertura (880 centros de atención primaria) y por tanto un gran número de pacientes atendidos (más de 32 millones de consultas médicas al año). Es el eslab...

  5. Can the Ni classification of vessels predict neoplasia? A systematic review and meta-analysis.

    Science.gov (United States)

    Mehlum, Camilla S; Rosenberg, Tine; Dyrvig, Anne-Kirstine; Groentved, Aagot Moeller; Kjaergaard, Thomas; Godballe, Christian

    2018-01-01

    The Ni classification of vascular change from 2011 is well documented for evaluating pharyngeal and laryngeal lesions, primarily focusing on cancer. In the planning of surgery it may be more relevant to differentiate neoplasia from non-neoplasia. We aimed to evaluate the ability of the Ni classification to predict laryngeal or hypopharyngeal neoplasia and to investigate if a changed cutoff value would support the recent European Laryngological Society (ELS) proposal of perpendicular vascular changes as indicative of neoplasia. PubMed, Embase, Cochrane, and Scopus databases. A systematic review and meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement. We systematically searched for publications from 2011 until 2016. All retrieved studies were reviewed and qualitatively assessed. The pooled sensitivity and specificity of the Ni classification with two different cutoffs were calculated, and bubble and summary receiver operating characteristics plots were created. The combined sensitivity of five studies (n = 687) with Ni type IV-V defined as test-positive was 0.89 (95% confidence interval [CI]: 0.76-0.95), and specificity was 0.82 (95% CI: 0.72-0.89). The equivalent combined sensitivity of four studies (n = 624) with Ni type V defined as test-positive was 0.82 (95% CI: 0.75-0.87), and specificity was 0.93 (95% CI: 0.82-0.97). The diagnostic accuracy of the Ni classification in predicting neoplasia was high, without significant difference between the two analyzed cutoff values. Implementation of the proposed ELS classification of vascular changes seems reasonable from a clinical perspective, with comparable accuracy. Attention must be drawn to the accompanying risk of exposing patients to unnecessary surgery. Laryngoscope, 128:168-176, 2018. © 2017 The American Laryngological, Rhinological and Otological Society, Inc.

  6. Reconocimiento a la Atención Primaria de Salud

    Directory of Open Access Journals (Sweden)

    Elso Manuel Cruz Cruz

    2014-08-01

    Full Text Available El presente número de nuestra revista constituye un reconocimiento necesario a la Atención Primaria de Salud (APS, estandarte del sistema de salud cubano, referente a nivel mundial. Son muchos los disímiles trabajos que se realizan desde la APS, imposibles de quedar ejemplificados en el muy limitado espacio que ofrece un número de la revista. Esta edición es sin dudas, especial, para ello se han escogido los resultados investigativos de variados trabajos, realizados desde la perspectiva de diferentes especialidades médicas, en diferentes escenarios, incluida la colaboración médica con países hermanos, pero todos con el denominador común de tributar a la Atención Primaria de Salud. Esperamos que estos artículos aporten relevantes conocimientos a nuestros lectores y se conviertan en referentes de sus trabajos investigativos. El número se confeccionó en los días que ambientaban el desarrollo de la Jornada Científica Provincial de Medicina Familiar, espacio de socialización de resultados científicos obtenidos en la APS. El comité editorial de la revista participó en las sesiones de trabajo del evento, reconociendo la calidad en el desarrollo del mismo y quedando en espera de que muchos de esos trabajos originales se divulguen a la comunidad en forma de artículos científicos

  7. Molecular events leading to HPV-induced high grade neoplasia

    Directory of Open Access Journals (Sweden)

    Saskia M. Wilting

    2016-12-01

    Full Text Available Cervical cancer is initiated by high-risk types of the human papillomavirus (hrHPV and develops via precursor stages, called cervical intraepithelial neoplasia (CIN. High-grade CIN lesions are considered true precancerous lesions when the viral oncogenes E6 and E7 are aberrantly expressed in the dividing cells. This results in abolishment of normal cell cycle control via p53 and pRb degradation. However, it has become clear that these viral oncogenes possess additional oncogenic properties, including interference with the DNA methylation machinery and mitotic checkpoints. Identification of the resulting molecular events leading to high-grade neoplasia will 1 increase our understanding of cervical carcinogenesis, 2 yield biomarkers for early diagnosis, and 3 identify therapeutic targets for HPV-induced (pre cancerous lesions.This review will briefly summarise current advances in our understanding of the molecular alterations in the host cell genome that occur during HPV-induced carcinogenesis.

  8. CONDICIONANTES DEL RENDIMIENTO ACADÉMICO EN LA ESCOLARIDAD PRIMARIA EN BRASIL: UN ANÁLISIS MULTIFACTORIAL

    Directory of Open Access Journals (Sweden)

    Mauro Mediavilla

    2016-03-01

    Full Text Available RESUMEN: Una problemática educativa actual en Brasil es el alto porcentaje de alumnos en la escolaridad primaria que muestran un bajo nivel académico. Esta situación justifica el análisis de los determinantes del rendimiento académico en matemáticas para la totalidad de alumnos y su comparación al colectivo con un rendimiento considerado insuficiente. Para ello, se emplea una aproximación lineal y multivariante a partir de los datos contenidos en la base de datos del Sistema de Avaliação da Educação Básica 2005. En conjunto, los resultados obtenidos permiten afirmar que las dimensiones asociadas a la educabilidad resultan determinantes para comprender los rendimientos observados en la educación primaria.

  9. Retrospective evaluation of toceranib phosphate (Palladia) use in cats with mast cell neoplasia.

    Science.gov (United States)

    Berger, Erika P; Johannes, Chad M; Post, Gerald S; Rothchild, Gillian; Shiu, Kai-Biu; Wetzel, Sarah; Fox, Leslie E

    2018-02-01

    Objectives The purpose of this study was to solicit and compile data from practicing veterinary specialists regarding their use of toceranib in cats with mast cell neoplasia and to provide initial assessment of possible clinical benefit and adverse events. Methods The American College of Veterinary Internal Medicine and Oncology listservs were used to solicit data pertaining to cases in which toceranib was used in the treatment of feline mast cell neoplasia. Cases were included if the following data were received: signalment (age, sex, breed), diagnosis of mast cell neoplasia by either cytology or histopathology, anatomic classification of disease (cutaneous, splenic/hepatic, gastrointestinal, other), previous and concurrent treatment, toceranib dose (mg/kg) and schedule, duration of therapy, best response and documentation of adverse events. Results Case data from 50 cats with cutaneous (n = 22), splenic/hepatic (visceral) (n = 10), gastrointestinal (n = 17) or other (n = 1) mast cell neoplasia were received. Clinical benefit was seen in 80% (40/50), including 86% (19/22) with cutaneous, 80% (8/10) with visceral and 76% (13/17) with gastrointestinal involvement. A majority of cats (n = 35) received glucocorticoids during toceranib treatment. Median duration of treatment in cats experiencing clinical benefit was 36 weeks (range 4-106 weeks), 48 weeks (range 12-199 weeks) and 23 weeks (range 13-81 weeks) for cutaneous, visceral and gastrointestinal cases, respectively. Toceranib was administered at a median dose of 2.5 mg/kg (range 1.6-3.5 mg/kg); in 90% (45/50) the drug was given three times per week. Treatment was generally well tolerated with 60% (30/50) of cats experiencing adverse events. The majority of these events were low-grade (grade 1 or 2) gastrointestinal or hematologic events that resolved with treatment break and/or dose adjustment. Conclusions and relevance Toceranib appears to be well tolerated in feline patients with mast cell neoplasia

  10. Synchronous high-risk melanoma and lymphoid neoplasia.

    LENUS (Irish Health Repository)

    Cahill, R A

    2012-02-03

    Large population-based studies have shown a significant association between melanoma and lymphoid neoplasia, particularly non-Hodgkin\\'s lymphoma (NHL) and chronic lymphocytic leukaemia (CLL), that is independent of any treatment received for the initial tumour. This study examines the presentation, diagnosis, treatment and progress of three patients who developed advanced melanoma concurrently with a lymphoid neoplasm (one NHL, two CLLs), in order to illustrate their association, discuss common aetiological factors and examine possible therapeutic options. As it is the melanoma rather than the lymphoid neoplasm that represents the bigger threat to overall survival, initial treatment should be targeted towards this cancer. However, because of the interplay between the diseases and the possible side-effects of the various treatments, the choice of adjuvant therapy requires careful consideration. Immunosuppression associated with chemotherapy may permit a more aggressive course for the melanoma, while locoregional radiotherapy is contraindicated following lymph node dissections. As immunotherapy is of benefit in the treatment of melanoma and has also been recently shown to be effective in the management of lymphoid neoplasia, we instituted interferon-alpha as adjuvant therapy for these patients, thereby utilizing a single agent to treat the dual pathologies. The three patients have now been followed-up for 6 months without evidence of disease recurrence or progression.

  11. Clima social escolar y rendimiento académico en comunicación en estudiantes de primaria – Lima, 2014

    OpenAIRE

    Pacheco Villarreal, Rosa Del Pilar

    2014-01-01

    La presente investigación titulada: “Clima Social Escolar y Rendimiento Académico en Comunicación de los estudiantes del V ciclo de primaria de la Institución Educativa N° 1157 Julio César Tello Rojas – Cercado de Lima, 2014”, tuvo como objetivo determinar la relación entre el clima social escolar y el rendimiento académico en comunicación de los estudiantes del V ciclo de primaria. Esto como respuesta al problema: ¿Qué relación existe entre clima social escolar y rendimient...

  12. EXPRESSION OF HPV 16 AND 18 IN CERVICAL INTRAEPITHELIAL NEOPLASIA

    Directory of Open Access Journals (Sweden)

    Kodali Venkataramana

    2017-03-01

    Full Text Available BACKGROUND Cervical cancer is by far the most common human papilloma virus related disease. Nearly, all cases of cervical cancer can be attributable to human papilloma virus infection. Infection with the human papilloma virus is the main risk factors for cervical intraepithelial neoplasia and cervical cancer especially the high-risk types. The aim of the study is to study the prevalence of high-risk human papilloma virus 16 and 18 in various grades of cervical intraepithelial neoplasia. MATERIALS AND METHODS It is a prospective study for a period of two years. 50 cases of cervical intraepithelial neoplasia of various grades on histopathology were included in the study. Polymerase chain reaction DNA sequencing was done in all the cases. The patients were followed up for 1 year with Pap smears and results tabulated. RESULTS 77.77% of cases were human papilloma virus 16 positive and 22.22% for human papilloma virus 18. High-risk human papilloma virus was positive in 66.66% of cases beyond 30 years of age. In cases with positive HPV 16 or 18, 62.5% of CIN 1 cases progressed to CIN 2 on follow up for one year,all the CIN2 cases progressed to CIN 3 and CIN 3 cases persisted in the same phase. CONCLUSION High-risk human papilloma virus testing beyond 30 years should be included in the screening test along with Pap smears.

  13. Sarcoma de Kaposi em paciente transplantada renal em uso de Fk-506 Kaposi's Sarcoma in a renal transplant patient receiving Fk-506

    Directory of Open Access Journals (Sweden)

    Jorge David Rocha Zanol

    2002-12-01

    Full Text Available O Sarcoma de Kaposi (SK é neoplasia maligna multicêntrica, cutânea e extracutânea, que tem sido descrita em pacientes transplantados renais que recebem terapia imunossupressora clássica. Este estudo descreve um caso de sarcoma de Kaposi em paciente transplantada renal recebendo FK-506, que surgiu 10 meses após o transplante.Kaposi's sarcoma is a cutaneous and extra cutaneous multicentric malignancy that has been widely described in renal-transplant patients under classic immunosuppressive therapy. This study describes a renal-transplant patient under immunosuppressive therapy with FK-506 who presented Kaposi's sarcoma 10 months after the transplantation.

  14. Detección de mutaciones germinales en el gen PMS2 asociado a Síndrome de Lynch

    OpenAIRE

    Álvarez Río, Virginia

    2014-01-01

    Según la Organización Mundial de la Salud (OMS) el cáncer se define como un término genérico que designa un amplio grupo de enfermedades que pueden afectar a cualquier parte del organismo; también se habla de «tumores malignos» o «neoplasias malignas». Una característica del cáncer es la multiplicación rápida de células anormales que se extienden más allá de sus límites habituales y pueden invadir partes adyacentes del cuerpo o propagarse a otros órganos, proceso conocido como ...

  15. Carcinoma adenóide cístico: relato de caso = Adenoid cystic carcinoma: case report

    Directory of Open Access Journals (Sweden)

    Palmeiro, Mariana Reuter

    2005-01-01

    Full Text Available O carcinoma adenóide cístico é uma neoplasia maligna rara de crescimento lento, caracterizado prognóstico reservado, devido a sua agressividade e grande potencial recidivante. A lesão é mais prevalente em pacientes na faixa etária entre 50 e 70 anos, sendo incomum em jovens. O artigo relata um caso de carcinoma adenóide cístico de glândulas salivares menores localizado no palato duro em pacientes com 26 ano, do sexo masculino que foi encaminhado para tratamento no Serviço de Cirurgia de Cabeça e Pescoço

  16. Efeito genotóxico do etanol em células da mucosa bucal

    OpenAIRE

    Reis, Silvia Regina de Almeida; Sadigursky, Moysés; Andrade, Miguel Gustavo Setúbal; Soares, Lívia Prates; Santo, Alexandre Ribeiro do Espírito; Vilas Bôas, Deise Souza

    2002-01-01

    O etanol é um dos agentes químicos relacionados ao desenvolvimento de neoplasias malignas bucais. Os micronúcleos são porções de cromatina que permanecem próximas ao núcleo, resultantes de mitoses aberrantes após a ação de agentes genotóxicos. Dessa forma, sua ocorrência reflete o grau de exposição celular a carcinógenos. O objetivo deste trabalho foi avaliar a freqüência de micronúcleos em células esfoliadas da língua e da mucosa jugal de indivíduos dependentes químicos de etanol. A amostra ...

  17. Cordoma Sacrococcígeo gigante: relato de caso Giant Sacrococcygeal chordoma: case report

    Directory of Open Access Journals (Sweden)

    Tiago Leal Ghezzi

    2009-06-01

    Full Text Available Cordoma sacrococcígeo é uma neoplasia maligna rara que se origina de remanescentes da notocorda. A localização crítica, comportamento localmente agressivo, reconhecida resistência à radioterapia, significativa morbimortalidade cirúrgica e elevada taxa de recidiva tornam seu tratamento um desafio. Descrevemos um caso de cordoma sacrococcígeo gigante.Sacrococcygeal chordoma is a rare malignant neoplasm arised from the remmants of the notochord. The critical localization, locally aggressive behavior, well-known resistance to radiation therapy, meaningful surgical morbimortality and increased recurrence rate become its treatment a challenge. We describe a case of a giant unresectable sacrococcygeal chordoma.

  18. Fine needle aspiration in salivary gland tumors: specificity and sensitivity

    OpenAIRE

    Gonçalves, Antonio José; Menezes, Marcelo Benedito; Kavabata, Norberto Kodi; Bertelli, Antonio Augusto Tupinambá; Souza, Ricardo Antenor de Souza e; Joelsons, Daniel

    2007-01-01

    As neoplasias das glândulas salivares são afecções que constituem aproximadamente 3% de todos os tumores da cabeça e pescoço. O tratamento cirúrgico adequado depende do correto conhecimento do tipo histológico, principalmente quando se trata de lesões malignas. Dessa maneira, a correta determinação do diagnóstico histológico pré-operatório auxilia em muito o planejamento terapêutico, porém, geralmente, isto é difícil de se estabelecer baseado apenas nos achados da história, exame clínico e de...

  19. Carcinoma Papilífero da Tireóide e Tireoidite de Hashimoto: uma revisão integrativa.

    OpenAIRE

    Brito, Jonathan Ferreira; Cavalcante, Tiago Rodrigues; Maia Junior, Reginaldo

    2016-01-01

    Introdução: O Carcinoma Papilífero de Tireóide é a neoplasia maligna mais comum da glândula tireóide. Sua associação com a Tireoidite de Hashimoto é reconhecida e investigada há seis décadas e muitos fatores dessa relação permanecem inexplicados.Objetivo: Avaliar a associação entre o Carcinoma Papilífero de Tireóide e a Tireoidite de Hashimoto.Material e Métodos: Foi realizada revisão integrativa de artigos que objetivavam compreender essa relação sob qualquer aspecto, fosse ele epidemiológic...

  20. Barreras para la atención en salud durante el diagnóstico y tratamiento del cáncer gástrico

    OpenAIRE

    Angélica María Amado-Niño; Leydi Yurani Mantilla-Villabona; Diana Carolina Ospina-Galeano; Dely María Auxiliadora Maturana-Martínez; Claudia Janeth Uribe-Pérez

    2018-01-01

    Introducción: El cáncer gástrico es una neoplasia maligna de alta morbimortalidad. Ocupa el quinto lugar en prevalencia mundial. Objetivo: Describir las barreras para la atención en salud durante el diagnóstico y tratamiento del cáncer gástrico. Metodología: Para la revisión de la literatura se emplearon bases de datos (PubMed, Lilacs, Ebsco, Science-direct, Ovid y google académico), que incluyó la consulta de ensayos clínicos, revisiones de tema y guías de manejo relacionadas con cáncer gást...

  1. Hybrid capture 2 viral load and the 2-year cumulative risk of cervical intraepithelial neoplasia grade 3 or cancer.

    Science.gov (United States)

    Castle, Philip E; Schiffman, Mark; Wheeler, Cosette M

    2004-11-01

    The purpose of this study was to determine the clinical value of a semiquantitative measure of human papillomavirus viral load by the hybrid capture 2 assay for stratification of the risk of histologic cervical intraepithelial neoplasia grade 3 or carcinoma. The Atypical Cells of Unknown Significance and Low-Grade Squamous Intraepithelial Lesions Triage Study was a randomized clinical trial of 5060 women with 2 years of follow-up to evaluate treatment strategies for women with equivocal or mildly abnormal cervical cytologic condition. The usefulness of the continuous hybrid capture 2 output relative light units/positive controls that were above the positive threshold (1.0 relative light units/positive controls), which was a surrogate for human papillomavirus viral load, for distinguishing between hybrid capture 2 positive women who were diagnosed with cervical intraepithelial neoplasia grade 3 or carcinoma during the study from those who were not diagnosed with cervical intraepithelial neoplasia grade 3 or carcinoma was examined with the use of receiver-operator characteristic analyses. Relative light units/positive controls values did not further discriminate between hybrid capture 2 positive women with cervical intraepithelial neoplasia grade 3 or carcinoma from those with less than cervical intraepithelial neoplasia grade 3 or carcinoma. The use of a cervical intraepithelial neoplasia grade 2 or more severe or carcinoma case definition did not alter our findings. Among women with atypical cells of unknown significance or low-grade squamous intraepithelial lesion cervical cytologic findings, the hybrid capture 2 viral load measurement did not improve the detection of 2-year cumulative cases of cervical intraepithelial neoplasia grade 3 or carcinoma significantly.

  2. lenguas en Educación Primaria

    Directory of Open Access Journals (Sweden)

    Charlène Paré

    2017-01-01

    Full Text Available En este artículo se analiza el cómic desde una perspectiva social, artística-literaria y educativa. El estudio se centra en el modelo francés, en el que las historietas ocupan un lugar importante, tanto como medio artístico como documento de lectura. Asimismo, se analizan de forma más concreta los beneficios del cómic en la enseñanza de las lenguas en la etapa de Educación Primaria. Los resultados muestran que el cómic es una elección idónea para esta etapa educativa, ya que permite la realización de actividades de comprensión lectora y expresión creativa, fomentando a la vez la motivación para la lectura en los niños.

  3. Long-term results of exclusive low-dose rate curie-therapy for a high-grade vaginal intraepithelial neoplasia

    International Nuclear Information System (INIS)

    Blanchard, P.; Monnier, L.; Dumas, I.; Azoury, F.; Mazeron, R.; Haie-Meder, C.

    2010-01-01

    The authors report the results of an exclusive low dose rate curie therapy for female patients treated for a grade 3 vaginal intraepithelial neoplasia. They reviewed the medical files of patients treated since 1983, i.e. 28 women. They analysed demographic characteristics, the clinic description of lesions, possible treatments which occurred before this high-grade vaginal intraepithelial neoplasia, possible previous history of cervical or endometrial cancer, curie therapy detailed data, presence of tumorous relapse. According to that, they conclude that a 60 Gy exclusive low- vaginal dose-rate curie-therapy is an efficient and well tolerated treatment for high-grade vaginal intraepithelial neoplasia. Short communication

  4. The role of surgery in the management of gestational trophoblastic neoplasia.

    Science.gov (United States)

    Doll, Kemi M; Soper, John T

    2013-07-01

    Although sensitive human chorionic gonadotropin assays and advances in chemotherapy have assumed primary importance in the management of gestational trophoblastic neoplasia, surgery remains important in the overall care of these patients. Management of molar pregnancies consists of surgical evacuation and subsequent monitoring. Hysterectomy decreases the risk of post-molar trophoblastic disease in appropriate patients and, when incorporated to primary management of gestational trophoblastic neoplasia, can decrease the chemotherapy requirements of patients with low-risk disease. In patients with high-risk disease, surgical intervention is frequently required to control complications of disease or as therapy to stabilize patients during chemotherapy. Hysterectomy, thoracotomy, or other extirpative procedures may be integrated into the management of patients with chemorefractory disease. Interventional procedures are useful adjuncts to control bleeding from metastases.

  5. Esophagectomy for Superficial Esophageal Neoplasia.

    Science.gov (United States)

    Watson, Thomas J

    2017-07-01

    Endoscopic therapies have become the standard of care for most cases of Barrett's esophagus with high-grade dysplasia or intramucosal adenocarcinoma. Despite a rapid and dramatic evolution in treatment paradigms, esophagectomy continues to occupy a place in the therapeutic armamentarium for superficial esophageal neoplasia. The managing physician must remain cognizant of the limitations of endoscopic approaches and consider surgical resection when they are exceeded. Esophagectomy, performed at experienced centers for appropriately selected patients with early-stage disease can be undertaken with the expectation of cure as well as low mortality, acceptable morbidity, and good long-term quality of life. Copyright © 2017 Elsevier Inc. All rights reserved.

  6. Chemotherapy for resistant or recurrent gestational trophoblastic neoplasia.

    LENUS (Irish Health Repository)

    Alazzam, Mo'iad

    2012-12-01

    Gestational trophoblastic neoplasia (GTN) is a highly curable group of pregnancy-related tumours; however, approximately 25% of GTN tumours will be resistant to, or will relapse after, initial chemotherapy. These resistant and relapsed lesions will require salvage chemotherapy with or without surgery. Various salvage regimens are used worldwide. It is unclear which regimens are the most effective and the least toxic.

  7. What is your diagnosis? [Intestinal neoplasia

    International Nuclear Information System (INIS)

    Uehlinger, P.; Glaus, T.; Stoeckli, R.; Flueckiger, M.; Leuch, F.

    1997-01-01

    Iron lack anemia due to chronic blood loss was diagnosed in a 12-year-old dog. Clinical abnormalities included weakness and episodic vomiting. Typical hematological abnormalities were moderate regenerative anemia (Hct 21 %) and microcytosis (MCV 39 fl.). Chronic occult blood loss in adult dogs most commonly occurs in the gastrointestinal tract, associated with ulcus or neoplasia. Possible diagnostic steps include radiographs, abdominal ultrasound, gastroduodenoscopy, and exploratory laparotomy. In the present case gastric and duodenal adenocarcinomata were found during necropsy, confirming the clinical suspicion of a bleeding gastrointestinal malignancy

  8. Análisis de materiales didácticos para enseñar Ciencias Sociales en Educación Primaria: “Un camino de ida y vuelta”

    OpenAIRE

    Mon Alday, Estefanía

    2013-01-01

    Con este Trabajo de Fin de Grado se pretende un acercamiento al tema del análisis de materiales didácticos para enseñar Ciencias Sociales en Educación Primaria y más concretamente se pretende analizar los materiales utilizados con el alumnado de 5º de primaria durante el desarrollo del Proyecto “Un Camino de Ida y Vuelta” en el Colegio Público de Educación Infantil y Primaria “Marqués de Santillana” en la localidad de Palencia. En la primera parte de este trabajo se realiza una revisión t...

  9. Tumores malignos de pálpebra Malignant eyelid tumors

    Directory of Open Access Journals (Sweden)

    Luis Henrique Schneider Soares

    2001-08-01

    Full Text Available Objetivos: Estudar a incidência de tumores malignos de pálpebra no Hospital Banco de Olhos de Porto Alegre. Métodos: Estudo retrospectivo dos casos de tumores malignos de pálpebra no período de 1985 a 1997, que tiveram diagnóstico confirmado por exame anátomopatológico. Resultados: Foram encontradas 54 neoplasias malignas, sendo 75,92% carcinoma basocelular, 12,96% carcinoma espinocelular, 7,40% melanoma e 1,85% lentigo maligna. A maioria dos pacientes apresentava mais de 40 anos e não houve prevalência de sexo. Conclusões: O tumor de pálpebra mais freqüente em nosso meio foi o carcinoma basocelular, seguido do carcinoma espinocelular. O melanoma foi o terceiro em freqüência mais encontrado em nossa pesquisa.Purposes: To study the incidence of eyelid malignant tumors in the Banco de Olhos Hospital of Porto Alegre from 1985 to 1997. Methods: We retrospectivelly analyzed clinical archives and in this study all cases of malignant eyelid tumors with histopathologic examination were included. Results: We found 54 eyelid tumors: 75.92% basal cell, 12.96% squamous cell, 7.40% melanoma, 1.85% undifferentiated carcinoma and 1.85% lentigo maligna. The majority of the patients was over 40 years old, 50% were male and 50% female. The diagnosis was confirmed in all cases through histopathologic examination. Conclusions: Basal cell carcinoma was the most frequent eyelid malignancy followed by squamous cell carcinoma. Melanoma was the third most frequently found tumor in our study.

  10. Elecciones primarias y personalización de la política: El caso de las elecciones locales en Chile 2012

    OpenAIRE

    CANTILLANA PEÑA, CARLOS; CONTRERAS AGUIRRE, GONZALO; MORALES QUIROGA, MAURICIO

    2015-01-01

    Aunque las elecciones primarias han sido popularizadas como el mecanismo de selección de candidatos más abierto y participativo, muchas veces generan el efecto contrario, fortaleciendo la personalización de la política y no la institucionalización de los partidos. Estudiamos las elecciones primarias de Chile organizadas por la coalición de centro-izquierda Concertación, para elegir sus candidatos a alcalde en 2012. Sostenemos, en primer lugar, que a mayor fuerza electoral del candidato incumb...

  11. Asociación entre las habilidades mentales primarias y el rendimiento académico en estudiantes de medicina de pregrado

    OpenAIRE

    Víctor Manuel Gómez-López; Sandra Rosales-Gracia; Griselda Marín-Solórzano

    2013-01-01

    Con el propósito de analizar la asociación que existe entre las habilidades mentales primarias cuando se ingresa a la carrera de medicina y el rendimiento académico cuando se termina el octavo semestre, se realizó un estudio observacional y retrospectivo en 121 egresados de la Licenciatura de Medicina de una escuela particular del norte de México. Las habilidades mentales primarias se consideraron como variables predictoras, en tanto el rendimiento académico se asumió como variables de result...

  12. Role of the human papilloma virus in the development of cervical intraepithelial neoplasia and malignancy

    OpenAIRE

    Jastreboff, A; Cymet, T

    2002-01-01

    Human papilloma virus (HPV) is a public health problem as a sexually transmitted disease and as a critical factor in the pathogenesis of various cancers. The clinical manifestations, epidemiology, and virology that are critical to understanding the process of cervical dysplasia and neoplasia are reviewed. A discussion of the cervical transformation zone and the classification of cervical dysplasia and neoplasia leads into the importance of the Papanicolaou smear in prevention of potentially d...

  13. CÂNCER INFANTO JUVENIL: PERFIL DE ÓBITOS

    Directory of Open Access Journals (Sweden)

    Joisy Aparecida Marchi

    2013-01-01

    Full Text Available Objetivou-se caracterizar os óbitos por neoplasias malignas de crianças e adolescentes residentes no Estado do Paraná entre os anos de 2001 e 2010. Estudo quantitativo, descritivo, transversal, baseado em dados secundários dos Sistemas de Informação de Mortalidade e Morbidade Hospitalar do Departamento de Informática do Sistema Único de Saúde, realizado de julho a dezembro de 2012. Foram analisadas as variáveis sexo, faixa etária, raça e município de residência. Como medida de associação, utilizou-se oddis ratio, confirmado através do teste χ2. Destacaram-se como principais causas de óbito as leucemias, as neoplasias do sistema nervoso central e os linfomas, incidentes no sexo feminino e na raça branca. Adolescentes apresentaram um risco aproximadamente três vezes maior de óbito em comparação com as crianças. A neoplasia infanto juvenil merece atenção especial diante da condição de vulnerabilidade desse grupo, sendo necessários novos estudos para verificar associação com possíveis fatores de risco.

  14. The Relationship Between Distal and Proximal Colonic Neoplasia : A Meta-Analysis

    NARCIS (Netherlands)

    Dodou, D.; De Winter, J.C.F.

    2011-01-01

    To investigate the association between proximal colonic neoplasia and distal lesions as a function of the lesion type. The extent to which health, demographic, and study characteristics moderate this association was also examined.

  15. Baremación de una Prueba Estandarizada de Resúmenes (RESUMeV Para los Niveles de 4º y 6º de Educación Primaria

    Directory of Open Access Journals (Sweden)

    José A. León

    2015-01-01

    Full Text Available El objetivo del estudio fue el de mostrar evidencias de fiabilidad y validez para una prueba de resúmenes (RESUMev que evalúa el grado de comprensión lectora en alumnos de cuarto y sexto de primaria. Participaron un total de 528 estudiantes de primaria, de los cuales 236 fueron estudiantes de 4º de primaria (9 y 10 años y 292 a 6º de primaria (11 a 13 años. Todos estos alumnos procedían de 21 centros escolares. Para evaluar la consistencia interna, se calculó el alfa de Cronbach en los criterios de evaluación de resúmenes (contenido, coherencia y estilo y su índice de homogeneidad (Hj . La validez se evaluó mediante la comparación entre niveles académicos. En cuanto a los resultados, se obtuvieron índices elevados significativos de fiabilidad y de validez. Los resultados proporcionan evidencia empírica para la validez de la prueba.

  16. Estrés laboral y síndrome de burnout en docentes cubanos de enseñanza primaria

    OpenAIRE

    Oramas Viera, Arlene

    2013-01-01

    El estrés laboral y el síndrome de burnout en el docente cubano de enseñanza primaria, a pesar del impacto negativo que suelen tener en la salud y el desempeño profesional, han sido poco estudiados. En el presente trabajo, con el objetivo de detectar la presencia del estrés laboral y el síndrome de burnout, en una muestra de 621 docentes de enseñanza primaria en cuatro provincias, se utilizó el Inventario de estrés para maestros, la Escala sintomática de estrés y el Inventario de burnout de M...

  17. Conocimiento de maestros de primaria sobre el trastorno por déficit de atención e hiperactividad

    OpenAIRE

    Reyes,Marina; Acuña,Laura

    2012-01-01

    El propósito del estudio fue averiguar la influencia del sexo, edad y clase social de maestros de primaria respecto del Trastorno por Déficit de Atención e Hiperactividad (TDAH), sus causas y como tratarlo. El estudio también averiguó la influencia del grado escolar y del tamaño del grupo que atendían los maestros, así como del tipo de escuela en la que trabajaban. Maestros de primaria (N = 691) señalaron si sabían qué era el TDAH y en caso afirmativo escribieron en qué consiste. También escr...

  18. Metodologías innovadoras para enseñanza de la lengua inglesa en la Educación Primaria

    OpenAIRE

    Salvador Esteban, Manuel Mariano

    2016-01-01

    La realización de este trabajo de fin de grado trata de poner de manifiesto la necesidad imperante que existe hoy en día del uso de metodologías innovadoras para la enseñanza de la lengua inglesa en educación primaria. Para ello se ha seguido un camino que comienza con el análisis de la situación de la lengua inglesa dentro del currículo de Educación Primaria que propone la LOMCE. El estudio no ha atendido únicamente a las propias especificaciones de la asignatura, sino que también la ha p...

  19. Duração da Neoplasia Intra-Epitelial e do Carcinoma Invasor do Colo Uterino: Estudo Epidemiológico Duration of Intraepithelial Neoplasia and Invasive Carcinoma of the Cervix in Relation to Age at Diagnosis

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Zeferino

    1998-12-01

    Full Text Available Objetivo: estimar a duração e o tempo de evolução da neoplasia do colo uterino, a partir da infecção por papilomavírus humano (HPV até as formas invasoras avançadas, tomando como parâmetro a idade média ao diagnóstico. Método: estudo observacional-transversal que incluiu 1.177 mulheres com infecção por HPV, 1.561 com neoplasia intra-epitelial cervical (NIV e 773 com carcinoma invasor. Resultados: não houve diferença estatisticamente significante entre as médias de idade ao diagnóstico da NIC 1 e NIC 2. A duração da NIC 2 foi 2,2 anos e da NIC 3 foi 10,3 anos, sendo 4,1 anos como displasia grave e 6,2 anos como carcinoma in situ (CIS. A duração da lesão intra-epitelial escamosa de alto grau foi 12,5 anos e do carcinoma invasor estádio Ia, Ib e II foram, respectivamente, 3,0, 2,7 e 3,7 anos. Conclusões: de acordo com os resultados deste estudo, as NIC 1 e NIC 2 originam-se diretamente da infecção por HPV e a maioria das NIC 2 seria uma lesão transiente. A lesão de maior duração é o CIS e o tempo médio do período subclínico da neoplasia do colo uterino é de 18,2 anos. Estes resultados são discutidos em função do conhecimento mais atual da história natural do carcinoma do colo uterino e de outros estudos que estimaram a duração desta neoplasia.Purpose: to estimate the duration of cervical neoplasia from human pappilomavirus (HPV infection to advanced invasive carcinoma, using as paremeter the mean age of the women at diagnosis. Methods: this cross-sectional study included 1,177 women with HPV infection, 1,561 with cervical intraepithelial neoplasia (CIN and 773 with invasive carcinoma. Results: the mean ages of CIN 1 and CIN 2 on diagnosis were not statistically different. The mean duration of CIN 2 was 2.2 years. The mean duration of CIN 3 was 10.3 years, with 4.1 years as severe dysplasia and 6.2 years as carcinoma in situ (CIS. The mean duration of high grade squamous intraepithelial lesions was 12

  20. Cribado para el trastorno bipolar en pacientes de atención primaria que presentan síntomas psicológicos

    Directory of Open Access Journals (Sweden)

    Enric Aragonès

    2015-03-01

    Conclusiones: El cribado del TB en pacientes de atención primaria con otros problemas psicológicos da lugar a una notable proporción de resultados positivos, lo que indica que puede haber una prevalencia relevante de pacientes con TB, la mayor parte de ellos no diagnosticados y no tratados adecuadamente. Es necesario profundizar en la investigación para determinar el eventual papel que puede o debe asumir la atención primaria en la detección, el diagnóstico o el manejo de este trastorno.

  1. La comprensi??n lectora en Educaci??n Primaria: una investigaci??n sobre las inferencias como estrategia b??sica de lectura

    OpenAIRE

    Rico Tello, Marina

    2015-01-01

    La comprensi??n lectora es una capacidad b??sica que debe adquirir el alumnado a lo largo su vida escolar y familiar, es por ello por lo que se llevar a cabo una investigaci??n educativa sobre la comprensi??n literal e inferencial en 22 alumnos de 3o de Educaci??n Primaria en el Centro de Educaci??n Infantil y Primaria Alcazaba (Granada). Se examinan las destrezas de las que disponen para comprender el significado literal e inferencial de un texto continuo o discontinuo a trav??s de una in...

  2. The prognostic significance of virus-associated changes in grade 1 cervical intra-epithelial neoplasia

    DEFF Research Database (Denmark)

    Bagi, P; Worning, A M; Nordsten, M

    1987-01-01

    Virus-associated changes of the cervix uteri were assessed in patients treated for grade 1 cervical intra-epithelial neoplasia (CIN). Of 106 patients evaluated, 67 (63%) had virus-associated changes. The patients were treated without regard to the presence/absence of virus-associated changes. In 26...... patients the treatment was unsuccessful (persistence, recurrence, or progression of the neoplasia). The frequency of treatment failure was 33% in patients with, and 10% in patients without virus-associated changes (p less than 0.025). It is recommended that patients with CIN 1 and virus-associated changes...

  3. Afectos y algoritmos alternativos en las aulas de primaria

    OpenAIRE

    Gamazo Alonso, Natalia

    2017-01-01

    El presente Trabajo Fin de Grado (TFG) recoge una sencilla investigación sobre la evolución del dominio afectivo matemático de una muestra de niños que trabajan las matemáticas con el método ABN (Abierto Basado en Números) y de una muestra de alumnos que las trabajan mediante algoritmos tradicionales. Junto con el análisis de la evolución de la afectividad hacia las matemáticas a lo largo de los cursos académicos que conforman la Educación Primaria, se establece también una comparativa ent...

  4. Indications for percutaneous nephrostomy in patients with obstructive uropathy due to malignant urogenital neoplasias

    Directory of Open Access Journals (Sweden)

    Frederico R. Romero

    2005-04-01

    Full Text Available INTRODUCTION: Urogenital neoplasias frequently progress with obstructive uropathy due to local spreading or pelvic metastases. The urinary obstruction must be immediately relieved in order to avoid deterioration in these patients. The percutaneous nephrostomy is a safe and effective method for relief the obstruction; however the indications of such procedures have been questioned in patients with poor prognosis. MATERIAL AND METHODS: A retrospective study was performed with 43 patients (29 female and 14 male with urogenital neoplasias who were undergoing percutaneous nephrostomy during a 54-month period. The median age was 52 years. The primary tumoral site was the uterine cervix in 53.5% of patients, the bladder in 23.3%, the prostate in 11.6% and other sites in 11.6%. RESULTS: Postoperative complications occurred in 42.3% of the patients. There was no procedure-related mortality. Thirty-nine per cent of the patients died during the hospitalization period due to advanced neoplasia. The mortality rate was higher in patients with prostate cancer (p = 0.006, in patients over 52 years of age (p = 0.03 and in those who required hemodialysis before the procedure (p = 0.02. Thirty-two per cent of the patients survived long enough to undergo some form of treatment focused on the primary tumor. The survival rate was 40% at 6 months and 24.2% at 12 months. The percentage of the lifetime spent in hospitalization was 17.7%. The survival rate was higher in patients with neoplasia of the uterine cervix (p = 0.007 and in patients with 52 years of age or less (p = 0.008. CONCLUSION: Morbidity was high in this patient group; however, the majority of patients could be discharged from hospital and followed at home. Patients under 52 years of age and patients with neoplasia of the uterine cervix benefited most from the percutaneous nephrostomy when compared to patients with hormone therapy-refractory prostate cancer, bladder cancer or over 52 years of age.

  5. Lobular neoplasia detected in MRI-guided core biopsy carries a high risk for upgrade: a study of 63 cases from four different institutions

    Science.gov (United States)

    Khoury, Thaer; Kumar, Prasanna R; Li, Zaibo; Karabakhtsian, Rouzan G; Sanati, Souzan; Chen, Xiwei; Wang, Dan; Liu, Song; Reig, Beatriu

    2017-01-01

    There are certain criteria to recommend surgical excision for lobular neoplasia diagnosed in mammographically detected core biopsy. The aims of this study are to explore the rate of upgrade of lobular neoplasia detected in magnetic resonance imaging (MRI)-guided biopsy and to investigate the clinicopathological and radiological features that could predict upgrade. We reviewed 1655 MRI-guided core biopsies yielding 63 (4%) cases of lobular neoplasia. Key clinical features were recorded. MRI findings including mass vs non-mass enhancement and the reason for biopsy were also recorded. An upgrade was defined as the presence of invasive carcinoma or ductal carcinoma in situ in subsequent surgical excision. The overall rate of lobular neoplasia in MRI-guided core biopsy ranged from 2 to 7%, with an average of 4%. A total of 15 (24%) cases had an upgrade, including 5 cases of invasive carcinoma and 10 cases of ductal carcinoma in situ. Pure lobular neoplasia was identified in 34 cases, 11 (32%) of which had upgrade. In this group, an ipsilateral concurrent or past history of breast cancer was found to be associated with a higher risk of upgrade (6/11, 55%) than contralateral breast cancer (1 of 12, 8%; P = 0.03). To our knowledge, this is the largest series of lobular neoplasia diagnosed in MRI-guided core biopsy. The incidence of lobular neoplasia is relatively low. Lobular neoplasia detected in MRI-guided biopsy carries a high risk for upgrade warranting surgical excision. However, more cases from different types of institutions are needed to verify our results. PMID:26564004

  6. El conocimiento del ciclo del agua en el segundo ciclo de Educación Primaria

    Directory of Open Access Journals (Sweden)

    María Guerrero Valle

    2017-07-01

    Full Text Available El agua tiene una gran importancia e influencia en nuestras vidas y en nuestro planeta. En este trabajo se presenta una investigación sobre el conocimiento sobre el ciclo del agua en el segundo ciclo de la Educación Primaria. Para el estudio, se ha realizado en dos centros de Primaria un cuestionario sobre lluvia que recoge los conceptos claves para una comprensión básica del mecanismo de la lluvia como del ciclo del agua, junto con un dibujo sobre la lluvia. La investigación pone de manifiesto que el grado de conocimiento sobre el ciclo del agua de los estudiantes es alto, pero se trata de un conocimiento incompleto y, en algunas ocasiones, erróneo. Después de reflexionar sobre los resultados obtenidos, se propone la implicación educativa necesaria para mejorar dichos resultados.

  7. Nuclear Receptors and Multiple Endocrine Neoplasia type 1 (MEN1)

    NARCIS (Netherlands)

    Dreijerink, K.M.A.

    2009-01-01

    Multiple Endocrine Neoplasia type 1 (MEN1) is an inherited syndrome that is characterized by the occurrence of tumours of the parathyroid glands, gastroenteropancreatic tumours, pitui-tary gland adenomas, as well as adrenal adenomas and neuro-endocrine tumours, often at a young age. MEN1 tumours can

  8. Conization, frozen section examination, and planned hysterectomy in the treatment of high-grade cervical intraepithelial neoplasia Conização, exame de congelação e histerectomia planejada no tratamento de neoplasia intra-epitelial de alto grau

    Directory of Open Access Journals (Sweden)

    Jesus Paula Carvalho

    2001-12-01

    Full Text Available PURPOSE: We tested the role of frozen section examination of the cone specimen in the evaluation of the resection margin status and to rule out invasion in patients with high-grade cervical intraepithelial neoplasia. METHODS: Twenty-five patients with cervical intraepithelial neoplasia underwent conization followed by frozen section examination and planned hysterectomy. The results of the definitive paraffin exam were compared with frozen section examination. RESULTS: In the evaluation of the margins by frozen section examination, 16 patients (64% had positive cone margins and 9 (36% had negative margins. The definitive paraffin examination of margin status was concordant in all the cases. Intraoperative diagnosis of invasion was made in 5 cases, and 1 of these was microinvasive. Among the remaining 20 cases, we detected 2 additional microinvasive carcinomas after paraffin study, so the diagnosis of the frozen section examination was concordant with the paraffin sections in 23/25 cases (92%. Two cases of microinvasive carcinoma were diagnosed as cervical intraepithelial neoplasia by frozen section examination and had less than 2 mm stromal invasion. CONCLUSIONS: In high-grade cervical intraepithelial neoplasia, frozen section examination can provide immediate and precise evaluation of the cone margin status in high-grade cervical intraepithelial neoplasia. It can identify frank invasion and permit adequate treatment in a one-stage procedure. In early microinvasive disease, frozen section examination fails to detect the area of invasion but reliably detects clear resection margins.OBJETIVOS: Foi avaliado o papel do exame intra-operatório de congelação no diagnóstico de invasão e no estado das margens cirúrgicas em pacientes com neoplasia intra-epitelial de alto grau. CASUÍSTICA E MÉTODO: Vinte e cinco pacientes com neoplasia intra-epitelial de alto grau foram submetidas a conização cervical seguida de histerectomia. O resultado do exame

  9. Funciones ejecutivas y Rendimiento Escolar en Educación Primaria

    OpenAIRE

    Caro-Franco, Federico

    2016-01-01

    En el presente Trabajo de Fin de Máster se ha investigado si existe vinculación entre el rendimiento escolar y las funciones ejecutivas en los alumnos que cursan Educación Primaria. Para ello, se evaluaron 32 alumnos de entre 6 y 8 años, 16 de los cuales presentaban un rendimiento académico bajo, y los restantes 16, un rendimiento académico normalizado. Para diagnosticar el grado de rendimiento de las funciones ejecutivas, se evaluó la atención, tanto sostenida como selectiva, la planificació...

  10. Hipertensión arterial pulmonar primaria o idiopática

    OpenAIRE

    Yazmín Ravelo-Calzado; Vivian Molina-Cuevas; María de Lourdes Arruzazabala-Valmaña; Daisy Carbajal-Quintana

    2010-01-01

    La hipertensión arterial pulmonar primaria (HAPP) es una enfermedad crónica de causa desconocida que se caracteriza por un incremento de la presión sanguínea media en la arteria pulmonar, mayor de 25 mmHg en reposo o más de 30 mmHg durante el ejercicio. Es una enfermedad que afecta a ambos sexos y no tiene predilección racial. La HAPP sin tratar puede conducir a una insuficiencia ventricular derecha y por consiguiente, a la muerte. La HAPP involucra varios mecanismos subyacentes, dentro de lo...

  11. Biópsia percutânea de lesões ósseas guiada por tomografia computadorizada: taxas de definição diagnóstica e complicações

    Directory of Open Access Journals (Sweden)

    Macello Jose Sampaio Maciel

    2014-10-01

    Full Text Available Objetivo: Determinar taxas de definição diagnóstica e complicações da biópsia percutânea guiada por tomografia computadorizada (TC de lesões ósseas suspeitas de malignidade. Materiais e Métodos: Estudo retrospectivo que incluiu 186 casos de biópsia percutânea guiada por TC de lesões ósseas no período de janeiro de 2010 a dezembro de 2012. Todas as amostras foram obtidas usando agulhas de 8 a 10 gauge. Foram coletados dados demográficos, história de neoplasia maligna prévia, dados relacionados à lesão, ao procedimento e ao resultado histológico. Resultados: A maioria dos pacientes era do sexo feminino (57% e a idade média foi 53,0 ± 16,4 anos. Em 139 casos (74,6% a suspeita diagnóstica era metástase e os tumores primários mais comuns foram de mama (32,1% e próstata (11,8%. Os ossos mais envolvidos foram coluna vertebral (36,0%, bacia (32,8% e ossos longos (18,3%. Houve complicações em apenas três pacientes (1,6%, incluindo uma fratura, um caso de parestesia com comprometimento funcional e uma quebra da agulha necessitando remoção cirúrgica. Amostras de 183 lesões (98,4% foram consideradas adequadas para diagnóstico. Resultados malignos foram mais frequentes nos pacientes com suspeita de lesão secundária e história de neoplasia maligna conhecida (p < 0,001 e nos procedimentos orientados pela PET/CT (p = 0,011. Conclusão: A biópsia percutânea guiada por TC é segura e eficaz no diagnóstico de lesões ósseas suspeitas.

  12. Beneficios y aplicaciones de la educación musical en alumnos con retraso mental en Educación Primaria

    OpenAIRE

    Catalina Presa, Isabel

    2016-01-01

    Este trabajo está dirigido a la investigación de los posibles beneficios que pueda ejercer la música sobre los alumnos de Educación Primaria haciendo hincapié en aquellos con la patología de retraso mental. En la primera parte del trabajo se lleva a cabo una investigación y un análisis teórico de los conceptos y contenidos de la educación musical en la enseñanza primaria y el retraso mental junto con la relación entre ambos. En la segunda parte llevo a cabo una propuesta de intervención...

  13. Comprensión y Producción Textual Narrativa en Estudiantes de Educación Primaria

    Directory of Open Access Journals (Sweden)

    LEIDY TATIANA GUZMÁN TORRES

    2015-01-01

    Full Text Available Por medio de un enfoque mixto, se caracterizó la comprensión y producción textual narrativa en estudiantes de educación primaria (primero y segundo grado, así como aspectos psicosociales (valor social de la lectura y hábito lector y contextuales (interacciones cognitivas y afectivas docente-niños en docentes de educación primaria de tres instituciones educativas. Se encontró que los estudiantes tuvieron un desempeño medio alto en producción textual y comprensión literal, y bajo en comprensión inferencial. Además, se observó que la mayoría de las docentes son lectoras ocasionales, emplean interacciones cognitivas unidireccionales, ofrecen un mediano apoyo emocional a sus estudiantes y valoran la lectura como una herramienta instrumental y lúdica.

  14. La estimulación del lenguaje oral a partir de los cuentos en el primer ciclo de educación primaria

    OpenAIRE

    Torres Jaramillo, Ana María

    2014-01-01

    El trabajo que se expone a continuación es una propuesta de intervención para trabajar el lenguaje oral en los alumnos del primer ciclo de Educación Primaria. En él, me he marcado unos objetivos, partiendo de la base legal del currículo de Educación Primaria, de modo que, esta propuesta de trabajo pueda desarrollarse en el aula formando parte del currículo. Contiene aspectos teóricos referidos al lenguaje, destacando la importancia del lenguaje oral y un breve desarrollo del lenguaj...

  15. Diversão em movimento: um projeto lúdico para crianças hospitalizadas no Serviço de Oncologia Pediátrica do Instituto Materno Infantil Prof. Fernando Figueira, IMIP Ludotherapy for hospitalized children: a ludotherapy program for hospitalized children in the Pediatrics Oncology Unit of the Instituto Materno Infantil Prof. Fernando Figueira, IMIP

    Directory of Open Access Journals (Sweden)

    Arli Melo Pedrosa

    2007-03-01

    Full Text Available O presente trabalho descreve as atividades lúdicas desenvolvidas na enfermaria de oncologia pediátrica do Instituto Materno Infantil Prof. Fernando Figueira (IMIP, com 60 pacientes portadores de neoplasias malignas, no período de janeiro de 2004 a janeiro de 2005. Descreve também as etapas do Projeto e apresenta os resultados obtidos, correlacionando as etapas do desenvolvimento da aprendizagem com os instrumentos lúdicos utilizados como recurso minimizador do processo de hospitalização, através dos itens mais solicitados, considerando, para essa análise, as idéias de Jean Piaget e Bruno Bettelheim.This paper describes a ludotherapy program implemented in the pediatrics oncology ward of the Instituto Materno Infantil Prof. Fernando Figueira (IMIP with 60 malignant neoplasia patients from January 2004 to January 2005. It describes the phases of the project, demonstrates results obtained, relating learning development phases and ludic tools used as a resource to mitigate hospitalization hardships through the most requested items. Jean Piaget and Bruno Bettelheim concepts were used in this assessment.

  16. Dificuldade diagnóstica em dois casos de neoplasia de células linfóides precursoras cutâneas primárias Diagnostic pitfalls in two cases of primary cutaneous neoplasia of precursor lymphocytes

    Directory of Open Access Journals (Sweden)

    Cláudia Regina Gomes Cardim Mendes de Oliveira

    2008-06-01

    Full Text Available O linfoma linfoblástico (LLB é uma neoplasia maligna de linfócitos precursores (B, T ou células NK. O comprometimento primário da pele é raro. Relatamos as características clínicas, anatomopatológicas e imunofenotípicas em dois pacientes com apresentação cutânea primária que, histologicamente, apresentavam infiltrado de células imaturas. A análise imunofenotípica foi realizada com amplo painel de anticorpos. A pesquisa de rearranjo no gene do receptor de células T (TCR-gama pelo método de reação em cadeia da polimerase (PCR resultou positiva em um caso, que era CD56 positivo, classificado como linfoma de células NK blásticas-símile. Este caso representa uma entidade distinta derivada de células precursoras num estágio precoce de uma via comum de diferenciação para células T e NK. O outro caso foi classificado como LLB-T com expressão aberrante de CD79a, o que poderia ser erroneamente interpretado. O diagnóstico correto depende da utilização de um amplo painel de anticorpos para caracterização imunofenotípica e avaliação molecular.The lymphoblastic lymphoma (LBL is a malignant neoplasm of precursor lymphocytes (B, T or NK-cells. The primary involvement of the skin is rare. We examined the clinical, anatomopathological and immunophenotypic features of two patients with primary cutaneous involvement. Histologically they showed an infiltrate of immature cells. The immunophenotypic analysis was performed with a comprehensive panel of antibodies. T-cell receptor rearrangement (TCR-gamma was analyzed with polymerase chain reaction (PCR and it was positive in one case, which was CD56 positive, classified as blastic NK-cell-like lymphoma. This case represents a distinct entity derived from precursor cells at an early stage of a common developmental pathway for T and NK cells. The other case was classified as T-cell lymphoblastic lymphoma with aberrant expression of CD79a, what could be a diagnostic pitfall. The

  17. Neoplasia no sítio da colostomia de paciente com megacólon chagásico: relato de caso Neoplasia at the site of the colostomy of patient with chagasic megacolon: case report

    Directory of Open Access Journals (Sweden)

    Thiago Agostini Braga

    2011-06-01

    Full Text Available A neoplasia no sítio da colostomia associada ao megacólon chagásico é uma entidade rara. Os autores relatam caso de um paciente com lesão avançada, o qual foi submetido a tratamento cirúrgico e discutem aspectos relacionados a esta afecção.Neoplasia at the site of the colostomy associated with chagasic megacolon is a rare clinical event. Here, the authors report the case of a patient with advanced lesion, who had to undergo surgical treatment, and discuss aspects related to this disease.

  18. Trabajo social y educación primaria. mediación hacia una cultura de paz

    Directory of Open Access Journals (Sweden)

    Norma Méndez Vega

    2003-01-01

    Full Text Available El presente artículo es un aporte para el trabajo social en la educación primaria. Destaca la importancia de trabajar a favor de una cultura de paz, y parte de que el ambiente de la educación primaria es propicio para este fin, ya que los niños y las niñas deben recibir la motivación hacia un mundo en el que la participación y el compromiso son elementos esenciales para promover la cultura de paz y calidad de vida. Ofrece algunos elementos teórico-metodológicos para que trabajo social se inserte en el ambiente y se constituya en mediador de procesos participativos con el resto de la comunidad escolar, constituída tanto por el personal docente, administrativo, padres, madres y equipos interdisciplinarios del Programa para el mejoramiento de la calidad de la educación y vida en las comunidades urbanas de atención prioritaria (PROMECUM

  19. Tumor neuroectodérmico primitivo renal. Reporte de un caso

    OpenAIRE

    Nestor Moisés Tineo Araque; Helen Daniela Uzcátegui Camacaro; Henrry Ramirez; Humberto Ruz

    2011-01-01

    El cáncer de riñón representa entre el 2 y 3% del total de las neoplasias malignas, encontrándose entre ellas el tumor neuroectodérmico (1,1% dentro del cáncer renal). En muchos casos el diagnóstico es tardío y se describe la triada clásica: dolor, hematuria y masa palpable. El ultrasonido y la tomografía axial computarizada son los métodos de diagnóstico más importantes y el éxito terapéutico se basa en la cirugía radical. Se presenta caso de paciente femenina de 23 años quien inicia enferm...

  20. Incidência e risco acumulado de câncer de boca no município de São Paulo: 1969, 1973, 1978 e 1998

    OpenAIRE

    Ricardo Luiz Lorenzi

    2003-01-01

    Introdução. O câncer de boca em 1998 foi a décima-primeira localização mais comum das neoplasias malignas, exceto pele, no sexo masculino, em São Paulo, com 1,6% dos casos. Dados do Registro de Câncer de São Paulo mostram que a incidência não diminuiu em anos recentes. A região é de alta incidência para esse tipo de câncer, em comparação às demais regiões brasileiras e mesmo em termos mundiais. Julgou-se de interesse de Saúde Pública verificar a incidência do câncer de boca no Município de Sã...

  1. Importancia de la pesquisa del cáncer de mama

    OpenAIRE

    Dinorah García Roque; Yaiset Borges de la Oliva

    2017-01-01

    El cáncer, es uno de los mayores problemas de Salud Pública en el mundo, siendo en términos epidemiológicos, la neoplasia maligna que más se diagnostica y la mayor causa de muerte en el sexo femenino. El cáncer de mama es el tumor más frecuente en mujeres, con una incidencia anual de casi 143 000 nuevos casos en los EEUU. Estas cifras han ido incrementándose progresivamente durante los últimos 50 años. En las Américas, el cáncer de mama es el más común y la segunda causa principal de muerte p...

  2. Recurrent respiratory papillomatosis: HPV genotypes and risk of high-grade laryngeal neoplasia.

    Directory of Open Access Journals (Sweden)

    Turid Omland

    Full Text Available Patients with recurrent respiratory papillomatosis (RRP in Norway treated between 1987 and 2009 were recruited to this cohort study. They were followed from disease onset and data recorded until January 2012. Here, we describe the distribution of human papillomavirus (HPV genotypes, the prevalence of multiple HPV infections, and the risk of high-grade laryngeal neoplasia and respiratory tract invasive carcinoma in a large cohort of patients with RRP. We also examined whether HPV genotype, gender, age or clinical course are risk factors for this development. Clinical records and histological specimens were reviewed. Using formalin-fixed paraffin-embedded biopsies, HPV genotyping were performed by quantitative polymerase chain reaction assays identifying 15 HPV types. HPV-negative specimens were analyzed by metagenomic sequencing. Paraffin blocks were available in 224/238 patients. The DNA quality was approved in 221/224 cases. HPV DNA was detected in 207/221 patients and all were HPV 6 or HPV 11 positive, comprising HPV 6 in 133/207, HPV 11 in 40/207 cases and HPV 6/11 in 15/207 cases. Co-infection with one or two high-risk HPV types together with HPV 6 or HPV 11 was present in 19/207 patients. Metagenomic sequencing of 14 HPV-negative specimens revealed HPV 8 in one case. In total, 39/221 patients developed high-grade laryngeal neoplasia. 8/221 patients developed carcinoma of the respiratory tract (six patients with laryngeal carcinoma and two patients with lung carcinoma. High-grade laryngeal neoplasias were found more frequently in HPV-negative versus HPV-positive patients, (RR = 2.35, 95% CI 1.1, 4.99, as well as respiratory tract carcinomas (RR = 48, 95% CI 10.72, 214.91. In summary, the majority of RRP were associated with HPV 6 and/or 11. HPV-negative RRP biopsies occurred more frequently in adult-onset patients, and were associated with an increased risk of laryngeal neoplasia and carcinoma in the respiratory tract.

  3. Paquidermoperiostosis (osteoartropatía hipertrófica primaria Pachydermoperiostosis (primary hypertrophic osteoarthropathy

    Directory of Open Access Journals (Sweden)

    Javier A. Cavallasca

    2006-04-01

    Full Text Available La paquidermoperiostosis u osteoartropatía hipertrófica primaria es una rara enfermedad caracterizada por compromiso cutáneo y osteoarticular. Comunicamos dos casos que presentaban hipocratismo digital, uñas en vidrio de reloj, agrandamiento óseo, tumefacción articular y diferentes grados de afectación cutánea, sin otros hallazgos clínicos relevantes. Ambos desconocían antecedentes familiares similares. El estudio radiográfico de las zonas comprometidas mostró periostosis. Con resultados de laboratorio y radiografía de tórax normales, y ausencia de evidencia clínica de otra enfermedad subyacente, se realizó diagnóstico de osteoartropatía hipertrófica primaria.Pachydermoperiostosis or primary hypertrophic osteoarthropathy is a rare disease characterized by cutaneous and osteo-arthicular involvement. We describe two patients with finger clubbing, watch crystal nails, bones thickenings, arthritis and different grades of skin affection, without other clinical manifestations. Both did not know of having relatives with the same alterations. Radiological studies of the affected areas showed periostosis. Because of normal laboratory results and chest radiography plus the absence of other underlying causes, diagnosis of primary hypertrophic osteoarthropathy was made.

  4. Detección del trastorno depresivo mayor en atención primaria. Una revisión

    Directory of Open Access Journals (Sweden)

    José Manuel Calvo Gómez

    2015-07-01

    Full Text Available Antecedentes: El trastorno depresivo mayor (TDM es una enfermedad frecuente en la población general y una de las principales causas de discapacidad en el mundo. La distinción entre los cambios que normalmente ocurren en el estado del ánimo y aquellos que están presentes en el espectro de los trastornos depresivos no es una tarea fácil, por esta razón se han propuestos varios mecanismos e instrumentos para mejorar la detección de este trastornos en la consulta de atención primaria. Objetivos: Evaluar si la detección sistemática rutinaria con instrumentos de tamizaje, con o sin sistemas de seguimiento y manejo integrado, es más efectiva que la atención usual en identificar pacientes con depresión, facilitar su tratamiento, y mejorar los resultados clínicos, a nivel de la atención primaria. Material y Métodos: Para determinar la utilidad del tamizaje sistemático para depresión a nivel de atención primaria, se llevó a cabo una búsqueda de estudios de casos y controles, cohortes y controlados aleatorizados, revisiones sistemáticas, y meta-análisis, en las bases de datos MEDLINE, Base de datos de revisiones sistemáticas Cochrane, Registro central de estudios controlados Cochrane, PsycINFO, y EMBASE, desde enero de 1976 hasta el 30 de abril de 2013. Resultados: La evidencia existente mostró que muchos casos de depresión no son detectados. Los médicos de atención primaria (MAP logran tasas de detección del trastorno depresivo entre el 30% y 40% (rango 7-70%, sin utilizar herramientas adicionales para el diagnóstico como las escalas de una, dos y tres preguntas. Los pacientes con los cuadros menos severos y más jóvenes son los menos detectados. Conclusiones: La evidencia encontrada muestra que el tamizaje para depresión a nivel de atención primaria con retroalimentación del resultado puede incrementar el reconocimiento del trastorno por parte del MAP. Sin embargo, el efecto de la retroalimentación sobre el tratamiento

  5. Violencia de pareja: tipo y riesgos en usuarias de atención primaria de salud en Cancún, Quintana Roo, México

    OpenAIRE

    Luis Sandoval-Jurado; María Valeria Jiménez-Báez; Gloria Rovira Alcocer; Omar Vital Hernandez; Fany Guadalupe Pat Espadas

    2017-01-01

    Objetivo: Identificar la prevalencia y el tipo de violencia de pareja en mujeres usuarias de una unidad de atención primaria y estimar los riesgos para cada tipo de violencia. Diseño: Casos (incidentes) y controles. Emplazamiento: Unidad de atención primaria en Cancún, Quintana Roo, México. Participantes: Mujeres mayores de 18 años con vida en pareja en los últimos 12 meses. Mediciones principales: Mediante escala para identificación de violencia validada para población mexicana, ...

  6. O papel da neutropenia no prognóstico do doente oncológico com pneumonia adquirida na comunidade The role of neutropenia on outcomes of cancer patients with community-acquired pneumonia

    Directory of Open Access Journals (Sweden)

    Fátima Caeiro

    2009-08-01

    Full Text Available A doença infecciosa contribui para uma elevada morbilidade e mortalidade no doente oncológico, representando a pneumonia adquirida na comunidade a mais frequente. O desenvolvimento de PAC no doente neoplásico parece advir da modificação de mecanismos de defesa imunitária resultante, quer da patologia maligna, quer do tratamento oncológico. O risco de infecção relacionada com o tipo de neoplasia pode associar-se ao défice de imunidade humoral, celular ou do número de neutrófilos. As doenças hematológicas malignas podem predispor o doente às infecções devido à substituição da medula por células neoplásicas. Consequentemente, estes doentes têm neutropenia funcional, apesar de apresentarem, muitas vezes, um número normal ou aumentado de neutrófilos. Por outro lado, estes doentes podem ter neutropenia como efeito secundário da quimioterapia e/ou radioterapia (neutropenia absoluta. A gravidade da neutropenia foi considerada como principal factor de risco isolado no doente neoplásico, com particular relevância se o número de neutrófilos ≤500cel/mm³. A mortalidade global atribuída à neutropenia febril no doente neoplásico é de 30-50%. Nas últimas décadas, o tratamento das infecções na população oncológica foi direccionado, primariamente, para o manuseamento da neutropenia febril, devido ao facto de o local da infecção não ser determinado em 50-80% dos casos. As guidelines da American Thoracic Society de 2001 utilizavam a neutropenia para identificar os quadros mais graves de PAC nos doentes oncológicos. Os doen tes com patologia hematológica e neutropenia funcional ou indivíduos com qualquer tipo de neoplasia e neutropenia absoluta foram excluídos das referidas guidelines. A decisão de incluir doentes com tumores sólidos não neutropénicos foi baseada, apenas, na opinião de especialistas. Assim, os clínicos podiam sentir-se confiantes e tratar a PAC no doente oncológico não neutropénico como na

  7. Developmental arrest of germ cells in the pathogenesis of germ cell neoplasia

    DEFF Research Database (Denmark)

    Rajpert-De Meyts, E; Jørgensen, N; Brøndum-Nielsen, K

    1998-01-01

    Clinical observations and epidemiological evidence suggest that important aetiopathological events that cause neoplastic transformation of the male germ cell may occur in fetal life or early infancy. The incidence of germ cell neoplasia is high in individuals with various disorders of gonadal...... development and sexual differentiation, such as gonadal dysgenesis or androgen insensitivity syndrome. Increased risk has also been noted in individuals with trisomy 21, idiopathic infertility and low birth weight. Infertility is sometimes associated with small aberrations of sex chromosomes (e.g. low...... frequency mosaicism XY/XO) which can also be found in patients with testicular cancer. The variety of conditions that predispose to testicular neoplasia and the rise in its incidence in many countries speaks for the influence of environmental factors which may affect genetically predisposed individuals. We...

  8. Asma bronquial. Atención primaria de salud

    Directory of Open Access Journals (Sweden)

    Reinaldo Pino Blanco

    2010-12-01

    Full Text Available El siguiente trabajo define las pautas a seguir en la atención primaria de salud para logran un adecuado seguimiento y control de los pacientes que sufren enfermedades respiratorias crónicas y en particular el asma bronquial. Se realiza una revisión profunda de las principales guías para el manejo de la enfermedad, así como las mejores evidencias publicadas hasta la fecha.This paper sets out the guidelines in the primary health care to achieve an adequate monitoring and control of patients suffering from chronic respiratory diseases including bronchial asthma. A systematic review on the main guidelines to handle this disease and the best evidence published to this day are presented.

  9. Molecular signatures of thyroid follicular neoplasia

    DEFF Research Database (Denmark)

    Borup, R.; Rossing, M.; Henao, Ricardo

    2010-01-01

    The molecular pathways leading to thyroid follicular neoplasia are incompletely understood, and the diagnosis of follicular tumors is a clinical challenge. To provide leads to the pathogenesis and diagnosis of the tumors, we examined the global transcriptome signatures of follicular thyroid...... a mechanism for cancer progression, which is why we exploited the results in order to generate a molecular classifier that could identify 95% of all carcinomas. Validation employing public domain and cross-platform data demonstrated that the signature was robust and could diagnose follicular nodules...... and robust genetic signature for the diagnosis of FA and FC. Endocrine-Related Cancer (2010) 17 691-708...

  10. New Developments in Ocular Surface Squamous Neoplasia

    Directory of Open Access Journals (Sweden)

    Ayşe Yağcı

    2014-09-01

    Full Text Available Ocular surface squamous neoplasia originates from conjunctiva epithelium and covers a broad spectrum of disease ranging from dysplasia to squamous cell carcinoma. Clinical features may vary from case to case. Traditional treatment of excision with no-touch technique combined with adjuvant therapies because of high recurrence rate. Main adjuvant treatments are cryotherapy and chemotherapy. In this review, clinical forms, differential diagnosis, American Joint Committee on Cancer classification and recent approaches to the management of ocular surface squamous dysplasia were described. (Turk J Ophthalmol 2014; 44: Supplement 8-14

  11. Is there any association between hormonal contraceptives and cervical neoplasia in a poor Nigerian setting?

    Directory of Open Access Journals (Sweden)

    Ajah LO

    2015-07-01

    Full Text Available Leonard Ogbonna Ajah,1,2 Chibuike Ogwuegbu Chigbu,2 Benjamin Chukwuma Ozumba,2 Theophilus Chimezie Oguanuo,2 Paul Olisaemeka Ezeonu1 1Department of Obstetrics and Gynaecology, Federal Teaching Hospital, Abakaliki, Nigeria; 2Department of Obstetrics and Gynaecology, University of Nigeria Teaching Hospital, Enugu, Nigeria Background: The association between hormonal contraception and cervical cancer is controversial. These controversies may hamper the uptake of hormonal contraceptives. Objective: To determine the association between hormonal contraceptives and cervical neoplasia. Materials and methods: This was a case-control study in which Pap-smear results of 156 participants on hormonal contraceptives were compared with those of 156 participants on no form of modern contraception. Modern contraception is defined as the use of such contraceptives as condoms, pills, injectables, intrauterine devices, implants, and female or male sterilization. Those found to have abnormal cervical smear cytology results were subjected further to colposcopy. Biopsy specimens for histology were collected from the participants with obvious cervical lesions or those with suspicious lesions on colposcopy. The results were analyzed with descriptive and inferential statistics at a 95% level of confidence. Results: A total of 71 (45.5%, 60 (38.5%, and 25 (16.0% of the participants on hormonal contraceptives were using oral contraceptives, injectable contraceptives, and implants, respectively. Cervical neoplasia was significantly more common among participants who were ≥35 years old (6% versus 1%, P<0.0001, rural dwellers (6% versus 3.5%, P<0.0001, unmarried (7.6% versus 3.5%, P<0.0001, unemployed (6.8% versus 3.5%, P<0.0001, less educated (6% versus 3.8%, P<0.0001, and had high parity (6.8% versus 3.6%, P<0.0001. There was no statistical significant difference in cervical neoplasia between the two groups of participants (7 [4.5%] versus 6 [3.8%], P=1.0. Conclusion

  12. ATYPICAL MITOTIC FIGURES AND THE MITOTIC INDEX IN CERVICAL INTRAEPITHELIAL NEOPLASIA

    NARCIS (Netherlands)

    VANLEEUWEN, AM; PIETERS, WJLM; HOLLEMA, H; BURGER, MPM

    1995-01-01

    We surveyed cervical intraepithelial neoplasia (CIN) to quantify the proliferation rate and the presence of normal and atypical mitotic figures. In the cervical tissue specimens of 127 women with CIN, the area with the highest cell proliferation was identified and, at that site, the proliferation

  13. Targeting Human Papillomavirus to Reduce the Burden of Cervical, Vulvar and Vaginal Cancer and Pre-Invasive Neoplasia

    DEFF Research Database (Denmark)

    Nygard, Mari; Hansen, Bo Terning; Dillner, Joakim

    2014-01-01

    BACKGROUND: Infection with high-risk human papillomavirus (HPV) is causally related to cervical, vulvar and vaginal pre-invasive neoplasias and cancers. Highly effective vaccines against HPV types 16/18 have been available since 2006, and are currently used in many countries in combination...... with cervical cancer screening to control the burden of cervical cancer. We estimated the overall and age-specific incidence rate (IR) of cervical, vulvar and vaginal cancer and pre-invasive neoplasia in Denmark, Iceland, Norway and Sweden in 2004-2006, prior to the availability of HPV vaccines, in order...... to establish a baseline for surveillance. We also estimated the population attributable fraction to determine roughly the expected effect of HPV16/18 vaccination on the incidence of these diseases. METHODS: Information on incident cervical, vulvar and vaginal cancers and high-grade pre-invasive neoplasias...

  14. p16 as a diagnostic marker of cervical neoplasia: a tissue microarray study of 796 archival specimens

    DEFF Research Database (Denmark)

    Lesnikova, Iana; Lidang, Marianne; Hamilton-Dutoit, Stephen

    2009-01-01

    from archival formalin fixed, paraffin-embedded donor tissues from 796 patients, and included cases of cervical intraepithelial neoplasia (CIN)1 (n = 249), CIN2 (n = 233), CIN3 (n = 181), and invasive cervical carcinoma (n = 133). p16INK4a expression was scored using two different protocols: 1......BACKGROUND: To evaluate the usefulness of this biomarker in the diagnosis of cases of cervical neoplasia we studied the immunohistochemical expression of p16INK4a in a large series of archival cervical biopsies arranged into tissue microarray format. METHODS: TMAs were constructed with tissue cores...... dysplasia or the presence of invasive carcinoma. CONCLUSION: Immunohistochemical analysis of p16INK4a expression is a useful diagnostic tool. Expression is related to the degree of histological dysplasia, suggesting that it may have prognostic and predicative value in the management of cervical neoplasia....

  15. Financial burden is associated with worse health-related quality of life in adults with multiple endocrine neoplasia type 1.

    Science.gov (United States)

    Peipert, Benjamin J; Goswami, Sneha; Helenowski, Irene; Yount, Susan E; Sturgeon, Cord

    2017-12-01

    Health-related quality of life and financial burden among patients with multiple endocrine neoplasia type 1 is poorly described. It is not known how financial burden influences health-related quality of life in this population. We hypothesized that the financial burden attributable to multiple endocrine neoplasia type 1 is associated with worse health-related quality of life. United States adults (≥18 years) with multiple endocrine neoplasia type 1 were recruited from the AMENSupport MEN online support group. Patient demographics, clinical characteristics, and financial burden were assessed via an online survey. The instrument Patient-Reported Outcomes Measurement Information System 29-item profile measure was used to assess health-related quality of life. Multivariable linear regression was used to identify significant variables in each Patient-Reported Outcomes Measurement Information System domain. Out of 1,378 members in AMENSupport, our survey link was accessed 449 times (33%). Of 153 US respondents who completed our survey, 84% reported financial burden attributable to multiple endocrine neoplasia type 1. The degree of financial burden had a linear relationship with worse health-related quality of life across all Patient-Reported Outcomes Measurement Information System domains (r = 0.36-0.55, P financial event(s). Borrowing money from friends/family (30%), unemployment (13%), and spending >$100/month out-of-pocket on prescription medications (46%) were associated consistently with impaired health-related quality of life (ß = 3.75-6.77, P times more likely to be unemployed and declare bankruptcy than the US population, respectively. This study characterizes the financial burden in patients with multiple endocrine neoplasia type 1. Individuals with multiple endocrine neoplasia type 1 report a high degree of financial burden, negative financial events, and unemployment. Each of these factors was associated with worse health-related quality of life

  16. Turner syndrome and meningioma: support for a possible increased risk of neoplasia in Turner syndrome.

    Science.gov (United States)

    Pier, Danielle B; Nunes, Fabio P; Plotkin, Scott R; Stemmer-Rachamimov, Anat O; Kim, James C; Shih, Helen A; Brastianos, Priscilla; Lin, Angela E

    2014-01-01

    Neoplasia is uncommon in Turner syndrome, although there is some evidence that brain tumors are more common in Turner syndrome patients than in the general population. We describe a woman with Turner syndrome (45,X) with a meningioma, in whom a second neoplasia, basal cell carcinomas of the scalp and nose, developed five years later in the absence of therapeutic radiation. Together with 7 cases of Turner syndrome with meningioma from a population-based survey in the United Kingdom, and 3 other isolated cases in the literature, we review this small number of patients for evidence of risk factors related to Turner syndrome, such as associated structural anomalies or prior treatment. We performed histological and fluorescent in situ hybridization (FISH) of 22q (NF2 locus) analyses of the meningeal tumor to search for possible molecular determinants. We are not able to prove causation between these two entities, but suggest that neoplasia may be a rare associated medical problem in Turner syndrome. Additional case reports and extension of population-based studies are needed. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  17. Human Papillomavirus DNA Detection in Menstrual Blood from Patients with Cervical Intraepithelial Neoplasia and Condyloma Acuminatum ▿

    OpenAIRE

    Wong, Sze Chuen Cesar; Au, Thomas Chi Chuen; Chan, Sammy Chung Sum; Chan, Charles Ming Lok; Lam, Money Yan Yee; Zee, Benny Chung Ying; Pong, Wei Mei; Chan, Anthony Tak Cheung

    2010-01-01

    The Papanicolaou test generates pain and embarrassment, and cytology screening has limited sensitivity for detection of cervical neoplasia. These factors urge the use of another screening test that can overcome these limitations. We explore a completely noninvasive method using detection of human papillomavirus (HPV) DNA in women's menstrual blood (MB). The participants were divided into 3 cohorts: (i) 235 patients with cervical intraepithelial neoplasia 3 (CIN 3) (n = 48), CIN 2 (n = 60), CI...

  18. Imaging Finding of Multiple Endocrine Neoplasia Type 1: Case Report

    International Nuclear Information System (INIS)

    Yum, Tae Jun; Cho, Hee Woo

    2012-01-01

    Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant inherited syndrome with characteristic clinical and radiological manifestations. Many reports on MEN1 have been published; however, no cases of radiologically diagnosed MEN1 have been reported. Therefore, we report on a radiologically diagnosed case of MEN1 with clinical symptoms of gastroduodenal ulcer.

  19. Influencia de la memoria verbal y la memo-ria visual sobre el rendimiento académico en Educación Primaria

    OpenAIRE

    Blanco-Cerro, Susana

    2013-01-01

    Objetivo. Estudiar la relación entre la memoria visual a corto y largo plazo, y la memoria verbal respecto al rendimiento académico en distintas áreas educativas en alumnos del ter-cer ciclo de Educación Primaria. Metodología. Para analizar las variables implicadas se ha aplicado el Test de la Figura Compleja de Rey (Meyer, 1995) y el Test de Memoria Auditiva Inmediata (Cordero, 2009) a una muestra de 30 alumnos de entre 10 y 12 años de Educa-ción Primaria. Para realizar los análisis estadíst...

  20. Caracterización de la neoplasia intraepitelial cervical en mujeres atendidas en el policlínico Jimmy Hirzel

    Directory of Open Access Journals (Sweden)

    Luisa Margarita Sánchez Alarcón

    2015-06-01

    Full Text Available Fundamento: el cáncer de cuello uterino es, después del cáncer de mama, el que más frecuentemente afecta a la mujer. La detección y tratamiento temprano de las neoplasias intraepiteliales cervicales garantizan la calidad de vida ante esta afección. Objetivos: caracterizar a las pacientes con neoplasias intraepiteliales cervicales que son atendidas en el policlínico “Jimmy Hirzel” en el municipio Bayamo, provincia Granma, en el período comprendido entre enero y diciembre de 2013. Métodos: se realizó un estudio descriptivo, retrospectivo, en un universo de 3450 pacientes a las que se realizó citología vaginal en el período de referencia; la muestra fueron las 55 mujeres cuyos exámenes resultaron positivos. Se midieron variables como tipo de neoplasia, edad, inicio de las relaciones sexuales, presencia de cervicitis, sepsis vaginal y hábitos de fumar. Los datos se procesaron por conteo simple, se tabularon utilizando valores absolutos y porcentajes. Resultados: la presencia de la neoplasia intraepitelial cervical fue de un 1,6 %, predominando las de bajo grado (NIC I. El grupo de edad más afectado fue el de 36 a 45 años. Otros factores asociados encontrados con relativa frecuencia, en orden decreciente, fueron: sepsis vaginal, inicio de las relaciones sexuales entre 15-20 años, cervicitis y el hábito de fumar. Conclusiones: existe poca incidencia de las neoplasias intraepiteliales en el área de salud y período estudiados.

  1. Efectividad de la terapia manual en pacientes con dismenorrea primaria

    OpenAIRE

    Mazoteras García, María Dolores

    2016-01-01

    La dismenorrea primaria (DP) debe considerarse como el desorden ginecológico crónico más doloroso en mujeres en edad reproductiva y debe ser considerado como un desorden multifactorial, se puede describir como un síndrome doloroso, sin causa orgánica objetiva, generalmente de tipo cólico en la parte inferior del abdomen que puede irradiar a la zona lumbar y a la pelvis y se pueden asociar síntomas como náuseas, diarrea, mareos, dolor de cabeza y vómitos; el dolor suele aparecer el primer día ...

  2. Comparison of computed tomography and radiography for detecting changes induced by malignant nasal neoplasia in dogs

    International Nuclear Information System (INIS)

    Park, R.D.; Beck, E.R.; LeCouteur, R.A.

    1992-01-01

    The ability of computed tomography and radiography to detect changes associated with nasal neoplasia was compared in dogs. Eighteen areas or anatomic structures were evaluated in 21 dogs for changes indicative of neoplasia. Computed tomography was superior (P < or = 0.05) to radiography for detecting changes in 14 of 18 areas. Radiography was not superior for detecting changes in any structure or area. Computed tomography reveals vital information not always detected radiographically to assist in providing a prognosis and in planning treatment for nasal neoplasms in dogs

  3. Human Papilloma Virus Identification in Breast Cancer Patients with Previous Cervical Neoplasia.

    Science.gov (United States)

    Lawson, James S; Glenn, Wendy K; Salyakina, Daria; Clay, Rosemary; Delprado, Warick; Cheerala, Bharathi; Tran, Dinh D; Ngan, Christopher C; Miyauchi, Shingo; Karim, Martha; Antonsson, Annika; Whitaker, Noel J

    2015-01-01

    Women with human papilloma virus (HPV)-associated cervical neoplasia have a higher risk of developing breast cancer than the general female population. The purpose of this study was to (i) identify high-risk HPVs in cervical neoplasia and subsequent HPV positive breast cancers which developed in the same patients and (ii) determine if these HPVs were biologically active. A range of polymerase chain reaction and immunohistochemical techniques were used to conduct a retrospective cohort study of cervical precancers and subsequent breast cancers in the same patients. The same high-risk HPV types were identified in both the cervical and breast specimens in 13 (46%) of 28 patients. HPV type 18 was the most prevalent. HPVs appeared to be biologically active as demonstrated by the expression of HPV E7 proteins and the presence of HPV-associated koilocytes. The average age of these patients diagnosed with breast cancer following prior cervical precancer was 51 years, as compared to 60 years for all women with breast cancer (p for difference = 0.001). These findings indicate that high-risk HPVs can be associated with cervical neoplasia and subsequent young age breast cancer. However, these associations are unusual and are a very small proportion of breast cancers. These outcomes confirm and extend the observations of two similar previous studies and offer one explanation for the increased prevalence of serious invasive breast cancer among young women.

  4. Human papilloma virus identification in breast cancer patients with previous cervical neoplasia

    Directory of Open Access Journals (Sweden)

    James Sutherland Lawson

    2016-01-01

    Full Text Available Purpose: Women with human papilloma virus (HPV associated cervical neoplasia have a higher risk of developing breast cancer than the general female population. The purpose of this study was to (i identify high risk for cancer HPVs in cervical neoplasia and subsequent HPV positive breast cancers which developed in the same patients and (ii determine if these HPVs were biologically active.Methods: A range of polymerase chain reaction (PCR and immunohistochemical techniques were used to conduct a retrospective cohort study of cervical precancers and subsequent breast cancers in the same patients. Results: The same high risk HPV types were identified in both the cervical and breast specimens in 13 (46% of 28 patients. HPV type 18 was the most prevalent. HPVs appeared to be biologically active as demonstrated by the expression of HPV E7 proteins and the presence of HPV associated koilocytes. The average age of these patients diagnosed with breast cancer following prior cervical precancer was 51 years, as compared to 60 years for all women with breast cancer (p for difference = 0.001. Conclusions: These findings indicate that high risk HPVs can be associated with cervical neoplasia and subsequent young age breast cancer. However these associations are unusual and are a very small proportion of breast cancers. These outcomes confirm and extend the observations of 2 similar previous studies and offer one explanation for the increased prevalence of serious invasive breast cancer among young women.

  5. PDX-1 Is a Therapeutic Target for Pancreatic Cancer, Insulinoma and Islet Neoplasia Using a Novel RNA Interference Platform

    Science.gov (United States)

    Liu, Shi-He; Rao, Donald D.; Nemunaitis, John; Senzer, Neil; Zhou, Guisheng; Dawson, David; Gingras, Marie-Claude; Wang, Zhaohui; Gibbs, Richard; Norman, Michael; Templeton, Nancy S.; DeMayo, Francesco J.; O'Malley, Bert; Sanchez, Robbi; Fisher, William E.; Brunicardi, F. Charles

    2012-01-01

    Pancreatic and duodenal homeobox-1 (PDX-1) is a transcription factor that regulates insulin expression and islet maintenance in the adult pancreas. Our recent studies demonstrate that PDX-1 is an oncogene for pancreatic cancer and is overexpressed in pancreatic cancer. The purpose of this study was to demonstrate that PDX-1 is a therapeutic target for both hormonal symptoms and tumor volume in mouse models of pancreatic cancer, insulinoma and islet neoplasia. Immunohistochemistry of human pancreatic and islet neoplasia specimens revealed marked PDX-1 overexpression, suggesting PDX-1 as a “drugable” target within these diseases. To do so, a novel RNA interference effector platform, bifunctional shRNAPDX-1, was developed and studied in mouse and human cell lines as well as in mouse models of pancreatic cancer, insulinoma and islet neoplasia. Systemic delivery of bi-shRNAhumanPDX-1 lipoplexes resulted in marked reduction of tumor volume and improved survival in a human pancreatic cancer xenograft mouse model. bi-shRNAmousePDX-1 lipoplexes prevented death from hyperinsulinemia and hypoglycemia in an insulinoma mouse model. shRNAmousePDX-1 lipoplexes reversed hyperinsulinemia and hypoglycemia in an immune-competent mouse model of islet neoplasia. PDX-1 was overexpressed in pancreatic neuroendocrine tumors and nesidioblastosis. These data demonstrate that PDX-1 RNAi therapy controls hormonal symptoms and tumor volume in mouse models of pancreatic cancer, insulinoma and islet neoplasia, therefore, PDX-1 is a potential therapeutic target for these pancreatic diseases. PMID:22905092

  6. AGRESIONES SUFRIDAS POR LAS PERSONAS QUE TRABAJAN EN ATENCIÓN PRIMARIA DE LA COMUNIDAD DE MADRID, 2011-2012

    Directory of Open Access Journals (Sweden)

    Teresa Rincón-del Toro

    2016-01-01

    Full Text Available Fundamentos: Las agresiones de usuarios a los profesionales de Atención Primaria se han incrementado en los últimos años. No existen estudios previos en atención primaria que abarquen toda una Comunidad Autónoma y todas las categorías profesionales. El objetivo del estudio fue caracterizar la violencia en atención primaria de la Comunidad de Madrid. Métodos: Estudio descriptivo multicéntrico de las notificaciones de agresiones sufridas por los profesionales de Atención Primaria de la Comunidad de Madrid. Las variables del estudio incluyeron características sociodemográficas de las personas agresoras y de las agredidas, el tipo de agresión, sus causas y consecuencias. Se calcularon la mediana, el rango intercuartílico y las frecuencias. Se realizó un análisis de regresión logística calculando las OR y sus IC95%. Resultados: En el periodo de estudio se notificaron 1.157 agresiones, el 53,07% las notificaron médicos. En el 4,7% de los casos hubo agresión física. El principal motivo fue la disconformidad con la atención recibida (36,1%. El personal no sanitario mostró menos riesgo de ser agredido físicamente que el personal sanitario (OR: 0,38; IC95%: 0,17-0,86. La agresión fue cometida por un hombre en el 56,8% de los casos y del grupo de edad entre 31-40 años en el 26,8%. La persona agredida fue mujer en el 84% de los casos, con una edad comprendida entre 45-60 años. El 10% de los profesionales notificaron las agresiones y el 5,9% la denunció. Conclusiones: El riesgo de sufrir agresión es mayor en el personal sanitario, especialmente médicos. Tanto en el perfil de las personas agresoras como de las agredidas se detectaron diferencias significativas por sexo y edad.

  7. A Left-Sided Prevalence of Lentigo Maligna: A UK Based Observational Study and Review of the Evidence

    Directory of Open Access Journals (Sweden)

    Mark Gorman

    2015-01-01

    Full Text Available Skin cancer has been shown to present asymmetrically, prevalent on the left side of the body, more so in subtypes of cutaneous melanoma such as lentigo maligna. Biases have been linked to cumulative UV light exposure and automobile driving patterns. Though left-right ratios have previously correlated with the side men or women tend to position themselves or countries drive on, more recent trends indicate a consistent left-sided bias. To clarify reasons for changing trends, a review of the evidence base and LM’s laterality in a UK cohort (99 cases 2000–2011 was conducted for the first time. The strong correlation of left-sided excess, found in both genders (ratios 1.381–1.5, P<0.05  X2 0.841, is congruent with more recent findings. Though evidence indicates that driving position is no longer a risk factor for LM, due most likely to improved car window UV protection, it remains the most commonly attributed cause. Understanding phenomena such as UV lights “scatter effect” or that cumulative exposure may not be a significant risk factor helps rationalize older conclusions that would otherwise appear contradictory. The reasons for left-sided excess remain unclear but may be due to factors requiring further research such as the body’s anatomical/embryological asymmetry.

  8. El texto argumentativo en 6º curso de educación primaria

    OpenAIRE

    Ibarra Aguirre, Artzeiz

    2016-01-01

    Propongo el texto argumentativo en 6.º curso de Educación Primaria en la asignatura de Educación Física. He analizado cuatro textos argumentativos escritos por el alumnado del nivel mencionado, con la finalidad de valorar el grado de su competencia comunicativa escrita; principalmente, he estudiado asuntos textuales y lingüísticos presentes en los textos producidos. Pretendo estimular la capacidad argumentativa en el alumnado. Como consecuencia de las conclusiones, propongo actividades para l...

  9. 5-Aminosalicylates reduce the risk of colorectal neoplasia in patients with ulcerative colitis: an updated meta-analysis.

    Directory of Open Access Journals (Sweden)

    Li-Na Zhao

    Full Text Available BACKGROUND: Although the chemopreventive effect of 5-aminosalicylates on patients with ulcerative colitis has been extensively studied, the results remain controversial. This updated review included more recent studies and evaluated the effectiveness of 5-aminosalicylates use on colorectal neoplasia prevention in patients with ulcerative colitis. METHODS: Up to July 2013, we searched Medline, Embase, Web of Science, Cochrane CENTRAL, and SinoMed of China for all relevant observational studies (case-control and cohort about the effect of 5-aminosalicylates on the risk of colorectal neoplasia among patients with ulcerative colitis. The Newcastle-Ottawa Scale was used to assess the quality of studies. Adjusted odds ratios (ORs were extracted from each study. A random-effects model was used to generate pooled ORs and 95% confidence intervals (95%CI. Publication bias and heterogeneity were assessed. RESULTS: Seventeen studies containing 1,508 cases of colorectal neoplasia and a total of 20,193 subjects published from 1994 to 2012 were analyzed. 5-aminosalicylates use was associated with a reduced risk of colorectal neoplasia in patients with ulcerative colitis (OR 0.63; 95%CI 0.48-0.84. Pooled OR of a higher average daily dose of 5-aminosalicylates (sulfasalazine ≥ 2.0 g/d, mesalamine ≥ 1.2 g/d was 0.51 [0.35-0.75]. Pooled OR of 5-aminosalicylates use in patients with extensive ulcerative colitis was 1.00 [0.53-1.89]. CONCLUSION: Our pooled results indicated that 5-aminosalicylates use was associated with a reduced risk of colorectal neoplasia in patients with ulcerative colitis, especially in the cases with a higher average daily dose of 5-aminosalicylates use. However, the chemopreventive benefit of 5-aminosalicylates use in patients with extensive ulcerative colitis was limited.

  10. Criptococosis cutánea primaria en paciente inmunocompetente.

    Science.gov (United States)

    Vázquez-Osorio, Igor; García-Rodiño, Sara; Rodríguez-Rodríguez, Marta; Labandeira, Javier; Suárez-Peñaranda, José Manuel; Sánchez-Aguilar, MDolores; Vázquez-Veiga, Hugo

    2016-05-15

    La criptococosis cutánea es una micosis propia de pacientes inmunodeprimidos, sobre todo aquellos con infección por el virusde la inmunodeficiencia humana (VIH). Sin embargo, existen casos infrecuentes de criptococosis cutánea en pacientes inmunocompetentes, que suelen simular otras dermatosis, lo que retrasa su diagnóstico y tratamiento. Presentamos el caso de un varón pluripatológico de 79 años, con úlceras dolorosas en dorso de mano derecha que no respondían a tratamientos tópicos. A través del estudio histopatológico y micológico se alcanzó el diagnóstico de criptococosis cutánea primaria, lográndose la remisión de las lesiones tras 6 meses de tratamiento con fluconazol.

  11. INTELIGENCIA MUSICAL, RENDIMIENTO ESCOLAR Y DESARROLLO INTEGRAL EN EDUCACIÓN PRIMARIA

    OpenAIRE

    de la Villa-Santotomás, Lorena

    2014-01-01

    Con esta investigación se pretende diseñar un programa de intervención para mejorar la inteligencia musical y la discriminación auditiva, potenciando el rendimiento escolar y el resto de inteligencias. En primer lugar, se utilizó una muestra de 30 alumnos de segundo de Primaria. Se analizó el nivel de desempeño de las distintas inteligencias a través del Cuestionario de Inteligencias Múltiples (Armstrong, 2001). En segundo lugar, se evaluó el nivel de discriminación auditiva co...

  12. Associação entre fatores epidemiológicos e neoplasias mamárias em cadelas

    OpenAIRE

    Ramos, Carolina Silva [UNESP

    2011-01-01

    Tumor de mama é a neoplasia mais freqüente em cadelas, entretanto, há controvérsias sobre os fatores que influenciam o seu desenvolvimento. Em estudos epidemiológicos destaca-se que os fatores ambientais são responsáveis por, pelo menos, 80% da incidência do câncer de mama em humanos. Com o objetivo de estabelecer fatores ambientais que possam contribuir para o desenvolvimento das neoplasias mamárias em cadelas, foram avaliadas as cadelas que se atendidas no Hospital Veterinário Governador La...

  13. Evaluation of intracranial neoplasia and noninfectious meningoencephalitis in dogs by use of short echo time, single voxel proton magnetic resonance spectroscopy at 3.0 Tesla.

    Science.gov (United States)

    Carrera, Inés; Richter, Henning; Beckmann, Katrin; Meier, Dieter; Dennler, Matthias; Kircher, Patrick R

    2016-05-01

    OBJECTIVE To investigate metabolite concentrations of the brains of dogs with intracranial neoplasia or noninfectious meningoencephalitis by use of short echo time, single voxel proton magnetic resonance spectroscopy ((1)H MRS) at 3.0 T. ANIMALS 29 dogs with intracranial lesions (14 with neoplasia [3 oligodendromas, 3 glioblastomas multiformes, 3 astrocytomas, 2 lymphomas, and 3 meningiomas] and 15 is with noninfectious meningoencephalitis) and 10 healthy control dogs. PROCEDURES Short echo time, single voxel (1)H-MRS at 3.0 T was performed on neoplastic and noninfectious inflammatory intracranial lesions identified with conventional MRI. Metabolites of interest included N-acetyl aspartate (NAA), total choline, creatine, myoinositol, the glutamine-glutamate complex (Glx), glutathione, taurine, lactate, and lipids. Data were analyzed with postprocessing fitting algorithm software. Metabolite concentrations relative to brain water content were calculated and compared with results for the healthy control dogs, which had been previously evaluated with the same (1)H MRS technique. RESULTS NAA, creatine, and Glx concentrations were reduced in the brains of dogs with neoplasia and noninfectious meningoencephalitis, whereas choline concentration was increased. Concentrations of these metabolites differed significantly between dogs with neoplasia and dogs with noninfectious meningoencephalitis. Concentrations of NAA, creatine, and Glx were significantly lower in dogs with neoplasia, whereas the concentration of choline was significantly higher in dogs with neoplasia. Lipids were predominantly found in dogs with high-grade intra-axial neoplasia, meningioma, and necrotizing meningoencephalitis. A high concentration of taurine was found in 10 of 15 dogs with noninfectious meningoencephalitis. CONCLUSIONS AND CLINICAL RELEVANCE (1)H MRS provided additional metabolic information about intracranial neoplasia and noninfectious meningoencephalitis in dogs.

  14. Mamary neoplasia in a closed beagle colony

    International Nuclear Information System (INIS)

    Taylor, G.N.; Shabestari, L.; Williams, J.; Mays, C.W.; Angus, W.; McFarland, S.

    1975-01-01

    The incidence rate of mammary neoplasia in a large colony of beagles and its relationship to internal skeletal and/or liver radiation, age, relatively late ovariectomy (4 years and older), endometritis, parity status, and adrenal weight was examined. Of these various factors, age was the only condition that was clearly correlated with changes in the mammary tumor incidence. The rate became significant at approximately eight years of age and increased progressively throughout the successively older age classes. Within the female dogs, the incidence of mammary cancer was higher that that of any other form of spontaneous malignancy

  15. La integración del videojuego educativo con el folklore. Una propuesta de aplicación en Educación Primaria

    Directory of Open Access Journals (Sweden)

    Sonsoles Ramos Ahijado

    2016-01-01

    Full Text Available El artículo se centra en una experiencia de innovación en Educación Primaria que forma parte del trabajo práctico de la asignatura Música y nuevas tecnologías del Grado en maestro de Educación Primaria impartida en la Escuela Universitaria de Educación y Turismo de Ávila (Universidad de Salamanca, enmarcada en el programa Prácticas de campo. Modalidad II (2015/2016_OP4 del Campus de Excelencia Internacional Studii Salamantini. Consiste en la aplicación del videojuego La granja musical a 46 alumnos de primero y segundo de Educación Primaria del CEIP Santa Ana de Ávila con la finalidad de recuperar la tradición popular del pasado, interpretarla en el presente y proyectarla hacia las nuevas generaciones del futuro, para familiarizar a los alumnos con sus raíces folklóricas. Los resultados demuestran un alto grado de consecución de los objetivos planteados, junto con una participación significativa de elementos innovadores, tanto en la vertiente de las estrategias didácticas como en la relativa a los recursos tecnológicos empleados.

  16. Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome.

    Science.gov (United States)

    Burn, John; Bishop, D Timothy; Mecklin, Jukka-Pekka; Macrae, Finlay; Möslein, Gabriela; Olschwang, Sylviane; Bisgaard, Marie-Luise; Ramesar, Raj; Eccles, Diana; Maher, Eamonn R; Bertario, Lucio; Jarvinen, Heikki J; Lindblom, Annika; Evans, D Gareth; Lubinski, Jan; Morrison, Patrick J; Ho, Judy W C; Vasen, Hans F A; Side, Lucy; Thomas, Huw J W; Scott, Rodney J; Dunlop, Malcolm; Barker, Gail; Elliott, Faye; Jass, Jeremy R; Fodde, Ricardo; Lynch, Henry T; Mathers, John C

    2008-12-11

    Observational and epidemiologic data indicate that the use of aspirin reduces the risk of colorectal neoplasia; however, the effects of aspirin in the Lynch syndrome (hereditary nonpolyposis colon cancer) are not known. Resistant starch has been associated with an antineoplastic effect on the colon. In a randomized, placebo-controlled trial, we used a two-by-two design to investigate the effects of aspirin, at a dose of 600 mg per day, and resistant starch (Novelose), at a dose of 30 g per day, in reducing the risk of adenoma and carcinoma among persons with the Lynch syndrome. Among 1071 persons in 43 centers, 62 were ineligible to participate in the study, 72 did not enter the study, and 191 withdrew from the study. These three categories were equally distributed across the study groups. Over a mean period of 29 months (range, 7 to 74), colonic adenoma or carcinoma developed in 141 participants. Of 693 participants randomly assigned to receive aspirin or placebo, neoplasia developed in 66 participants receiving aspirin (18.9%), as compared with 65 receiving placebo (19.0%) (relative risk, 1.0; 95% confidence interval [CI], 0.7 to 1.4). There were no significant differences between the two groups with respect to the development of advanced neoplasia (7.4% and 9.9%, respectively; P=0.33). Among the 727 participants receiving resistant starch or placebo, neoplasia developed in 67 participants receiving starch (18.7%), as compared with 68 receiving placebo (18.4%) (relative risk, 1.0; 95% CI, 0.7 to 1.4). Advanced adenomas and colorectal cancers were evenly distributed in the two groups. The prevalence of serious adverse events was low, and the events were evenly distributed. The use of aspirin, resistant starch, or both for up to 4 years has no effect on the incidence of colorectal adenoma or carcinoma among carriers of the Lynch syndrome. (Current Controlled Trials number, ISRCTN59521990.) 2008 Massachusetts Medical Society

  17. Estudo comparativo entre citopatologia e histopatologia no diagnóstico de neoplasias caninas

    Directory of Open Access Journals (Sweden)

    Magalhães Adelaide M.

    2001-01-01

    Full Text Available Foi realizado um estudo comparativo entre os diagnósticos citológico e histopatológico em diversas neoplasias de 150 cães, pelas colorações de Wright, May-Grünwald-Giemsa, Novo Azul de Metileno e Papanicolau. Colorações histológicas como Hematoxilina-Eosina, van Gieson, Sudan, Azul de Toluidina e Ácido Periódico de Schiff também foram empregadas. Os dados revelaram uma eficácia de ordem de 85,3% no diagnóstico citopatológico, considerando-se os resultados histopatológicos como corretos. Em 4,0% dos casos somente a origem embrionária das neoplasias foi estabelecida. Em 1,3% das neoplasias apenas o prognóstico foi determinado; o diagnóstico citológico diferiu da histopatologia em 8,1% dos casos. Em dois casos (1,3% o diagnóstico citológico diferiu do histológico, mas um reexame determinou que o primeiro estava correto, o que elevou a sua eficácia para 86,6%. Entre as técnicas utilizadas, a punção aspirativa por agulha fina foi o melhor método para obter amostras. A citologia não foi adequada para o diagnóstico de neoplasias mamárias, dadas às variações morfológicas em diferentes áreas. A impressão em lâmina não é recomendada para análise de tumores mesenquimais e deve ser substituída pela citologia esfoliativa. O Wright revelou-se o método de coloração mais eficiente. As colorações adaptadas da histopatologia, van Gieson em leiomiomas e leiomiossarcomas, Sudan em lipomas e lipossarcomas, e Ácido Periódico de Schiff e Azul de Toluidina em mastocitomas, foram empregadas com sucesso fornecendo assim maior clareza de detalhes para as diversas neoformações de origem epitelial e mesenquimal.

  18. Análisis de ideas de docentes de educación primaria sobre diversidad familiar

    Directory of Open Access Journals (Sweden)

    Alvaro Capano Bosch

    2016-10-01

    Full Text Available Este artículo intenta indagar en las ideas de los docentes de educación primaria sobre los modelos familiares que se apartan del tradicional de familia nuclear. Se trabajó con 60 docentes de Montevideo y zona metropolitana respondiendo el Cuestionario de Ideas de los Docentes sobre Diversidad Familiar –CIDF– (Morgado, Jiménez-Lagares & González, 2009. Los datos obtenidos refieren que los docentes no mantienen una visión homogénea de los distintos tipos de hogares. Las familias adoptivas, las de progenitores divorciados y las monoparentales bajo responsabilidad de madres tuvieron mejor aceptación entre los docentes que las homoparentales o las encabezadas en solitario por un padre. Los ítems relativos a familias homoparentales fueron respondidos por menos personas. Los docentes con formación de posgrado se mostraron más tolerantes y flexibles ante la diversidad familiar. Se discuten estos resultados a la luz de las necesarias adaptaciones en la educación primaria con respecto a la diversidad de familias que allí asisten.

  19. Fractal dimension and image statistics of anal intraepithelial neoplasia

    International Nuclear Information System (INIS)

    Ahammer, H.; Kroepfl, J.M.; Hackl, Ch.; Sedivy, R.

    2011-01-01

    Research Highlights: → Human papillomaviruses cause anal intraepithelial neoplasia (AIN). → Digital image processing was carried out to classify the grades of AIN quantitatively. → The fractal dimension as well as grey value statistics was calculated. → Higher grades of AIN yielded higher values of the fractal dimension. → An automatic detection system is feasible. - Abstract: It is well known that human papillomaviruses (HPV) induce a variety of tumorous lesions of the skin. HPV-subtypes also cause premalignant lesions which are termed anal intraepithelial neoplasia (AIN). The clinical classification of AIN is of growing interest in clinical practice, due to increasing HPV infection rates throughout human population. The common classification approach is based on subjective inspections of histological slices of anal tissues with all the drawbacks of depending on the status and individual variances of the trained pathologists. Therefore, a nonlinear quantitative classification method including the calculation of the fractal dimension and first order as well as second order image statistical parameters was developed. The absolute values of these quantitative parameters reflected the distinct grades of AIN very well. The quantitative approach has the potential to decrease classification errors significantly and it could be used as a widely applied screening technique.

  20. El lenguaje en la educación: prácticas de lectura y escritura en preescolar básica y primaria 2005

    OpenAIRE

    Flórez Romero, Rita; Moreno Angarita, Marisol

    2005-01-01

    El proyecto Hablar, leer y escribir en preescolar y primaria para la participación, el éxito académico y la vida adulta se define, en primera instancia, como una acción cooperativa entre profesores universitarios, profesionales, docentes de preescolar y educación básica primaria, padres de familia y niños. Su intención fundamental es la de contribuir a la transformación de la realidad educativa de los niños y las niñas en edades comprendidas entre los 4 y los 11 años, con el fin d...

  1. Alumnos con Bajo Rendimiento Escolar, los blogs y el tutor de Primaria

    OpenAIRE

    Rico-Sánchez, Jesús David

    2013-01-01

    Teniendo en cuenta el problema que tiene el sistema educativo español con un índice muy elevado de fracaso escolar, se pretendió investigar concretamente sobre los alumnos del sexto curso de Primaria que presentan Bajo Rendimiento Escolar aprovechando los avances tecnológicos existentes en la actualidad y que han penetrado con gran fuerza en la sociedad. Por ello, el problema planteado en este trabajo es estudiar si el potencial motivador, comunicativo y utilitario del Edublog puede ayudar a ...

  2. 3-GROUP METAPHASE AS A MORPHOLOGIC CRITERION OF PROGRESSIVE CERVICAL INTRAEPITHELIAL NEOPLASIA

    NARCIS (Netherlands)

    MOURITS, MJE; PIETERS, WJLM; HOLLEMA, H; BURGER, MPM

    OBJECTIVE: The purpose of our study was to investigate the presence of three-group metaphase in progressive cervical intraepithelial neoplasia. STUDY DESIGN: This was a retrospective histologic study on the conization specimens of 41 women with microinvasive cervical carcinoma, 28 of whom were

  3. Three-group metaphase as a morphologic criterion of progressive cervical intraepithelial neoplasia

    NARCIS (Netherlands)

    Mourits, M. J.; Pieters, W. J.; Hollema, H.; Burger, M. P.

    1992-01-01

    OBJECTIVE: The purpose of our study was to investigate the presence of three-group metaphase in progressive cervical intraepithelial neoplasia. STUDY DESIGN: This was a retrospective histologic study on the conization specimens of 41 women with microinvasive cervical carcinoma, 28 of whom were

  4. Imaging of multiple endocrine neoplasia (MEN II A)

    International Nuclear Information System (INIS)

    Tanaka, Hiroko; Kohno, Atsushi; Nojiri, Yoko

    1995-01-01

    A retrospective review of diagnostic imaging findings of 20 cases of multiple endocrine neoplasia II A (MEN II A) was performed. The characteristic findings of thyroidal medullary carcinomas were relatively well-defined hypo- to isoechoic masses on US and coarse calcifications on plain X-ray. The pheochromocytomas were smaller in size and less enhancing than the sporadic ones, and they revealed marked high intensity on T2WI of MRI. We consider that these imaging findings were useful for the supplementary diagnosis of MEN II A. (author)

  5. Cushing Disease in a patient with Multiple Endocrine Neoplasia type 2B.

    Science.gov (United States)

    Kasturi, Kannan; Fernandes, Lucas; Quezado, Martha; Eid, Mary; Marcus, Leigh; Chittiboina, Prashant; Rappaport, Mark; Stratakis, Constantine A; Widemann, Brigitte; Lodish, Maya

    2017-06-01

    Multiple endocrine neoplasia type 2B (MEN2B) is a rare autosomal-dominant cancer syndrome characterized in part by metastatic medullary thyroid cancer (MTC) and pheochromocytoma. Cushing disease is a rare cause of endogenous hypercortisolism in children. We describe a 21-year-old African-American male who was diagnosed at age 10 with an ACTH-secreting pituitary microadenoma. At age 16 he developed medullary thyroid cancer and was found to have multiple endocrine neoplasia type 2B with the characteristic M918T mutation of the RET proto-oncogene. Following thyroidectomy, he was initiated on Vandetanib, a tyrosine kinase inhibitor, and has since had stable disease over the last 5 years. Our patient is the first individual with MEN2B to be described with Cushing disease. The RET oncogene may play a role in pituitary tumorigenesis; alternatively, the coexistence of these two entities may represent an extremely rare coincidence.

  6. Educación Primaria

    Directory of Open Access Journals (Sweden)

    Maite Serna

    2017-01-01

    Full Text Available Este trabajo surge del interés de evaluar la biblioteca escolar como medio lector, como generadora y aleccionadora de hábitos lectores. Pretende responder a la cuestión de si las directrices que rigen las actuaciones en torno a la lectura de las bibliotecas escolares de Bizkaia, en el País Vasco, son convenientes y fructíferas. Con este objetivo, primero se ha realizado un análisis detallado de los hábitos lectores y las percepciones sobre la importancia de la lectura que tienen los escolares y sobre quién los induce. Posteriormente hemos elaborado un estudio diagnóstico de las bibliotecas de centros de Educación Primaria, analizando su trabajo como agente lector y su integración e implicación con la comunidad educativa. Y finalmente se ha establecido la relación de los dos análisis anteriores para ver hasta qué punto la existencia de una biblioteca escolar favorece o no los hábitos lectores, concluyendo, por una parte, que la actitud y el estímulo familiar son elementos básicos para favorecer los hábitos lectores y, por otra, que la mera presencia de una biblioteca escolar en el centro no es suficiente para mejorar hábitos o valoración de la lectura, sino que la clave está en el tipo de biblioteca que trabaja con los escolares.

  7. Four Cases of Spontaneous Neoplasia in the Naked Mole-Rat (Heterocephalus glaber), A Putative Cancer-Resistant Species.

    Science.gov (United States)

    Taylor, Kyle R; Milone, Nicholas A; Rodriguez, Carlos E

    2017-01-01

    The naked mole-rat (Heterocephalus glaber) is widely acclaimed to be cancer-resistant and of considerable research interest based on a paucity of reports of neoplasia in this species. We have, however, encountered four spontaneous cases of neoplasia and one presumptive case of neoplasia through routine necropsy and biopsy of individuals in a zoo collection of nonhybrid naked mole-rats bred from a single pair. One case each of metastasizing hepatocellular carcinoma, nephroblastoma (Wilms' tumor), and multicentric lymphosarcoma, as well as presumptive esophageal adenocarcinoma (Barrett's esophagus-like) was identified postmortem among 37 nonautolyzed necropsy submissions of naked mole-rats over 1-year-old that were submitted for necropsy between 1998 and August 2015. One incidental case of cutaneous hemangioma was also identified antemortem by skin biopsy from one naked mole-rat examined for trauma. © The Author 2016. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  8. First-line chemotherapy in low-risk gestational trophoblastic neoplasia.

    LENUS (Irish Health Repository)

    Alazzam, Mo'iad

    2012-01-01

    This is an update of a Cochrane review that was first published in Issue 1, 2009. Gestational trophoblastic neoplasia (GTN) is a rare but curable disease arising in the fetal chorion during pregnancy. Most women with low-risk GTN will be cured by evacuation of the uterus with or without single-agent chemotherapy. However, chemotherapy regimens vary between treatment centres worldwide and the comparable benefits and risks of these different regimens are unclear.

  9. Efectividad de un programa multicomponente para dejar de fumar aplicado en atención primaria

    Directory of Open Access Journals (Sweden)

    Fernando Alonso-Pérez

    2014-05-01

    Conclusiones: El tratamiento multicomponente aplicado fue altamente efectivo. Se sugiere la conveniencia de realizar un entrenamiento específico a los profesionales de la salud de cara a implantar este tipo de intervenciones en el ámbito de la atención primaria, como alternativa al consejo médico para aquellos fumadores que lo precisen.

  10. Role of the human papilloma virus in the development of cervical intraepithelial neoplasia and malignancy.

    Science.gov (United States)

    Jastreboff, A M; Cymet, T

    2002-04-01

    Human papilloma virus (HPV) is a public health problem as a sexually transmitted disease and as a critical factor in the pathogenesis of various cancers. The clinical manifestations, epidemiology, and virology that are critical to understanding the process of cervical dysplasia and neoplasia are reviewed. A discussion of the cervical transformation zone and the classification of cervical dysplasia and neoplasia leads into the importance of the Papanicolaou smear in prevention of potentially devastating sequelae of this virus. The role of the immune system in the progression of the disease and how it relates to vaccines, as well as treatment and prevention of HPV, are reviewed.

  11. High-Dose Ursodeoxycholic Acid Is Associated With the Development of Colorectal Neoplasia in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis

    Science.gov (United States)

    Eaton, John E.; Silveira, Marina G.; Pardi, Darrell S.; Sinakos, Emmanouil; Kowdley, Kris V.; Luketic, Velimir A.C.; Harrison, M. Edwyn; McCashland, Timothy; Befeler, Alex S.; Harnois, Denise; Jorgensen, Roberta; Petz, Jan; Lindor, Keith D.

    2011-01-01

    OBJECTIVES Some studies have suggested that ursodeoxycholic acid (UDCA) may have a chemopreventive effect on the development of colorectal neoplasia in patients with ulcerative colitis (UC) and primary sclerosing cholangitis (PSC). We examined the effects of high-dose (28–30 mg/kg/day) UDCA on the development of colorectal neoplasia in patients with UC and PSC. METHODS Patients with UC and PSC enrolled in a prior, multicenter randomized placebo-controlled trial of high-dose UDCA were evaluated for the development of colorectal neoplasia. Patients with UC and PSC who received UDCA were compared with those who received placebo. We reviewed the pathology and colonoscopy reports for the development of low-grade or high-grade dysplasia or colorectal cancer. RESULTS Fifty-six subjects were followed for a total of 235 patient years. Baseline characteristics (including duration of PSC and UC, medications, patient age, family history of colorectal cancer, and smoking status) were similar for both the groups. Patients who received high-dose UDCA had a significantly higher risk of developing colorectal neoplasia (dysplasia and cancer) during the study compared with those who received placebo (hazard ratio: 4.44, 95% confidence interval: 1.30–20.10, P=0.02). CONCLUSIONS Long-term use of high-dose UDCA is associated with an increased risk of colorectal neoplasia in patients with UC and PSC. PMID:21556038

  12. Single-session endoscopic resection and focal radiofrequency ablation for short-segment Barrett's esophagus with early neoplasia.

    Science.gov (United States)

    Barret, Maximilien; Belghazi, Kamar; Weusten, Bas L A M; Bergman, Jacques J G H M; Pouw, Roos E

    2016-07-01

    The management of early neoplasia in Barrett's esophagus (BE) requires endoscopic resection of visible lesions, followed by radiofrequency ablation (RFA) of the remaining BE. We evaluated the safety and efficacy of combining endoscopic resection and focal RFA in a single endoscopic session in patients with early BE neoplasia. This was a retrospective analysis of patients with early BE neoplasia and a visible lesion undergoing combined endoscopic resection and focal RFA in a single session. Consecutive ablation procedures were performed every 8 to 12 weeks until complete endoscopic and histologic eradication of dysplasia and intestinal metaplasia were reached. Forty patients were enrolled, with a median C1M2 BE segment, a visible lesion with a median diameter of 15 mm, and invasive carcinoma in 68% of cases. Endoscopic resection was performed by using the multiband mucosectomy technique in 80% of cases, and the Barrx(90) catheter (Barrx Medical, Sunnyvale, Calif) was used for focal ablation. When an intention-to-treat analysis was used, both complete remission of all neoplasia and intestinal metaplasia were 95% after a median follow-up of 19 months. Stenoses occurred in 33% of cases and were successfully managed with a median number of 2 dilations. In 43% of patients, 1 single-session treatment resulted in complete histologic remission of intestinal metaplasia. Combining endoscopic resection and focal RFA in a single session appears to be effective. Less-aggressive RFA regimens could limit the adverse event rates. Copyright © 2016 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.

  13. Surgical approach in patients with hyperparathyroidism in multiple endocrine neoplasia type 1: total versus partial parathyroidectomy

    Directory of Open Access Journals (Sweden)

    Francesco Tonelli

    2012-01-01

    Full Text Available Usually, primary hyperparathyroidism is the first endocrinopathy to be diagnosed in patients with multiple endocrine neoplasia type 1, and is also the most common one. The timing of the surgery and strategy in multiple endocrine neoplasia type 1/hyperparathyroidism are still under debate. The aims of surgery are to: 1 correct hypercalcemia, thus preventing persistent or recurrent hyperparathyroidism; 2 avoid persistent hypoparathyroidism; and 3 facilitate the surgical treatment of possible recurrences. Currently, two types of surgical approach are indicated: 1 subtotal parathyroidectomy with removal of at least 3-3 K glands; and 2 total parathyroidectomy with grafting of autologous parathyroid tissue. Transcervical thymectomy must be performed with both of these procedures. Unsuccessful surgical treatment of hyperparathyroidism is more frequently observed in multiple endocrine neoplasia type 1 than in sporadic hyperparathyroidism. The recurrence rate is strongly influenced by: 1 the lack of a pre-operative multiple endocrine neoplasia type 1 diagnosis; 2 the surgeon's experience; 3 the timing of surgery; 4 the possibility of performing intra-operative confirmation (histologic examination, rapid parathyroid hormone assay of the curative potential of the surgical procedure; and, 5 the surgical strategy. Persistent hyperparathyroidism seems to be more frequent after subtotal parathyroidectomy than after total parathyroidectomy with autologous graft of parathyroid tissue. Conversely, recurrent hyperparathyroidism has a similar frequency in the two surgical strategies. To plan further operations, it is very helpful to know all the available data about previous surgery and to undertake accurate identification of the site of recurrence.

  14. Estudio del impacto en el nivel de comprensión lectora en inglés a través del uso de mapas conceptuales en estudiantes de 5to grado de primaria

    OpenAIRE

    Vega Bello, Ana Lilia

    2015-01-01

    Con la posibilidad de tener transversalidad en el trabajo de los docentes del idioma inglés con los docentes frente a grupo y debido a la inserción de dicho idioma en primarias públicas, es que surge el cuestionamiento ¿Existe modificación en la comprensión lectora en idioma inglés al usar mapas conceptuales en la materia de Ciencias Naturales de 5to año de primaria? La presente investigación se aplicó a 60 estudiantes de 5to grado de primaria de una escuela pública en el Distrito Federal. Co...

  15. Proyecto de intervención para el desarrollo de la psicomotricidad en una alumna de Educación Primaria: un estudio en una muestra sevillana

    OpenAIRE

    Sevillano Muñiz, Isabel María

    2016-01-01

    El siguiente Trabajo Fin de Grado, correspondiente al Grado de Educación Primaria, presenta un proyecto de intervención dirigido al desarrollo psicomotriz de una alumna del primer ciclo de Educación Primaria con necesidades educativas especiales. Una exhaustiva revisión bibliográfica fundamenta el marco teórico que incluye tanto conceptos claves referidos al ámbito psicomotor, como los centrados en los instrumentos de investigación cualitativa que han permitido obtener la infor...

  16. Actividades extraescolares y rendimiento académico en alumnos de primaria

    Directory of Open Access Journals (Sweden)

    Ramón Cladellas Pros

    2013-08-01

    Full Text Available El objetivo de este trabajo es valorar la posible incidencia en el rendimiento académico de alumnos de primaria, de la realización -o no- de actividades extraescolares, según su tipología (recreativas, cognitivas o ambas y el número de horas de actividades realizadas. La muestra final estaba formada por un total de 721 alumnos de primaria (366 niños y 355 niñas procedentes de diversos centros escolares de las comarcas catalanas y de las Islas Baleares. Se facilitó a los padres de los alumnos un cuestionario en el que debían indicar las notas obtenidas en diferentes materias (matemáticas, catalán, castellano, idiomas, gimnasia y plástica y responder datos relacionados con la realización de actividades extraescolares. Los resultados muestran cómo la realización de algún tipo de actividad extraescolar, sea del tipo que sea, mejora el rendimiento académico de los niños y niñas de la muestra. La sola realización de algún tipo de actividad (ya sea recreativa o cognitiva, o una combinación de ambas, incide positivamente y significativamente en los resultados obtenidos en todas las materias estudiadas, a excepción de las asignaturas de matemáticas, gimnasia y plástica. Asimismo, un número elevado de horas de actividades extraescolares (más de 10 horas y media a la semana afecta negativamente a los resultados obtenidos en todas las materias menos en gimnasia.

  17. Matemáticas, materiales manipulativos y rutinas Proyecto para segundo de Primaria

    OpenAIRE

    Fraile-Bravo, Maria

    2017-01-01

    Este trabajo presenta un proyecto que pretende crear una rutina de trabajo en el aula de segundo de primaria, en la cual se trabajen las matemáticas con materiales manipulativos. Esta forma de trabajar tiene el objetivo de mejorar la competencia matemática de los alumnos y fomentar un espacio en el que los alumnos operen con las matemáticas de manera concreta para después llegar al concepto abstracto correspondiente. Todo lo desarrollado en el proyecto se halla fundamentado en ...

  18. Evaluación de la adherencia primaria a medicamentos en pacientes con enfermedades crónicas afiliados al Seguro de Salud del Hospital Italiano de Buenos Aires: estudio de cohorte retrospectiva

    Directory of Open Access Journals (Sweden)

    Francisco Emiliano Peper

    2018-02-01

    Conclusiones: Este es el primer estudio que evaluó la adherencia primaria en Argentina y, según los resultados de nuestra búsqueda, el primero en el mundo para tamoxifeno. La adherencia primaria documentada en nuestra investigación fue algo mayor que la informada en la bibliografía.

  19. Evaluación del grado de sellado marginal y resistencia adhesiva de restauraciones de resina compuesta con adhesivo convencional en dentición primaria y definitiva

    OpenAIRE

    Monsalves Bravo, Silvia Isabel; Terrazas Soto, Pedro; Toro Urbina, Georgina; Bader Mattar, Marcelo

    2014-01-01

    El presente estudio evaluó el grado de sellado marginal y resistencia adhesiva de restauraciones de resinas compuestas confeccionadas con un sistema adhesivo de grabado y lavado en dentición primaria y definitiva. Para realizar ambos test se utilizaron 20 piezas primarias y 20 piezas definitivas. En resistencia al cizallamiento, los dientes fueron seccionados longitudinalmente y se les adhirió un cilindro de resina compuesta, utilizando la técnica adhesiva de grabado y lavado para ambas denti...

  20. Thyroid neoplasia risk is increased nearly 30 years after the Chernobyl accident.

    Science.gov (United States)

    Tronko, Mykola; Brenner, Alina V; Bogdanova, Tetiana; Shpak, Victor; Oliynyk, Valeriy; Cahoon, Elizabeth K; Drozdovitch, Vladimir; Little, Mark P; Tereshchenko, Valeriy; Zamotayeva, Galyna; Terekhova, Galyna; Zurnadzhi, Lyudmila; Hatch, Maureen; Mabuchi, Kiyohiko

    2017-10-15

    To evaluate risk of thyroid neoplasia nearly 30 years following exposure to radioactive iodine (I-131) from the 1986 Chernobyl nuclear accident, we conducted a fifth cycle of thyroid screening of the Ukrainian-American cohort during 2012-2015, following four previous screening cycles started in 1998. We identified 47 thyroid cancers (TC) and 33 follicular adenomas (FA) among 10,073 individuals who were <18 years at the time of the accident and had a mean I-131 dose of 0.62 Gy. We found a significant I-131 dose response for both TC and FA, with an excess odd ratio per Gy of 1.36 (95% CI: 0.39-4.15) and 2.03 (95% CI: 0.55-6.69), respectively. The excess risk of malignant and benign thyroid neoplasia persists nearly three decades after exposure and underscores the importance of continued follow-up of this cohort to characterize long-term pattern of I-131 risk. © 2017 UICC.

  1. La implementación local de la atención primaria en la Argentina: estudio de caso en el municipio de Lanús, provincia de Buenos Aires

    Directory of Open Access Journals (Sweden)

    Sara Ardila Gómez

    Full Text Available Se presentan resultados en Argentina de la segunda etapa de un estudio multicéntrico sobre Atención Primaria en Salud, realizado por la Universidad Nacional de Lanús y por la Red de Investigación en Sistemas y Servicios de Salud del Cono Sur, financiado por el International Development Research Center (Canadá. Se indagó sobre la traducción en servicios, prácticas y procesos de los abordajes y modelos de la Atención Primaria en Salud. Eso es un estudio de caso que aplicó el cuestionario de Evaluación Rápida de Atención Primaria en Salud (Barbara Starfield; adaptación y validación por Almeida/Macinko a usuarios y profesionales de centros de salud del Municipio de Lanús. Se entrevistó a gestores y fueron realizados talleres participativos. Los resultados señalan que el índice global de desempeño de la Atención Primaria en Salud en el municipio fue satisfactorio, con puntuaciones altas en las dimensiones 'vínculo con profesionales' y 'formación profesional', y bajas en 'acceso' y 'orientación a la comunidad'.

  2. Escalas de evaluación de riesgo suicida en atención primaria

    Directory of Open Access Journals (Sweden)

    Claudia Ximena Rangel Garzón

    2015-10-01

    Conclusiones. Estas escalas se pueden usar como instrumento de ayuda para definir una conducta en un paciente con riesgo suicida, pero no reemplazan la entrevista psiquiátrica. Se postulan las escalas Modified Scale for Suicide Ideation y Plutchik Suicide Risk Scale por cumplir con las características psicométricas, por tener un tiempo de aplicación adecuado en el servicio de urgencias y por sus preguntas sencillas para ser utilizadas en atención primaria.

  3. Escribir ciencia: un desafío que comienza en la escuela primaria

    Directory of Open Access Journals (Sweden)

    Carina Rudolph

    2016-01-01

    Full Text Available Este estudio considera que el docente de ciencias debería ser mediador en la adquisición de habilidades de lectura y escritura en el área de Ciencias Naturales. Esto implica hacer transitar progresivamente a los estudiantes en los géneros específicos de las disciplinas, comenzando desde la escuela primaria. Este artículo propone el abordaje del género relato de procedimiento con el objeto de favorecer el aprendizaje de contenidos científicos mediante la escritura del procedimiento seguido en actividades experimentales llevadas a cabo en las clases de Ciencias Naturales. El estudio fue realizado en una escuela primaria de San Juan (Argentina con estudiantes de quinto grado en dos encuentros en los que se abordaron contenidos relacionados con el sonido y sus características. En el análisis de las producciones escritas por los alumnos consideramos la estructura del relato elaborado en cada instancia y el contenido científico explicitado en las producciones. Los resultados sugieren que el guion de estructura del género proporcionado a los estudiantes ha favorecido la comunicación escrita del relato acerca de los experimentos realizados. Esto se evidencia en aspectos relacionados con el orden de las ideas, su presentación en forma más completa y los intentos de explicación de los fenómenos en estudio, mejorando el uso del lenguaje de la ciencia y el aprendizaje disciplinar.

  4. Scrotal neoplasia: would truck drivers be at greater risk?

    Directory of Open Access Journals (Sweden)

    Daniel Seabra

    2007-08-01

    Full Text Available OBJECTIVE: To analyze how scrotal neoplasias have been managed during the past decade and to question possible factors or professions associated to its presence. MATERIALS AND METHODS: We retrospectively evaluated every case reported from 1995 to 2005 at our hospital. We described the clinical scenario, complementary exams, treatments and outcomes. We also tried to verify if there was any risk, predisposing factors or professions that would explain the cancer origin. RESULTS: Six cases were reviewed. Out of these, three patients were truck drivers. Five of them showed restricted lesions without inguinal lymph nodes enlargement. Histologically, six patients presented squamous carcinoma, with two of them having the verrucous type. The median age of patients was 52 years old (31 to 89. The five patients who are still alive had their lesions completely removed with safety margin and primary closure. CONCLUSIONS: We have noticed that the scrotal carcinoma behavior is similar to that of the penis, where removal of the lesion and study of the regional lymph nodes help to increase the patient survival rate. The outstanding fact was that three out of six patients were truck drivers, raising the hypothesis that such profession, maybe due to the contact or attrition with the diesel exhaust expelled by the engine or to sexual promiscuity, would imply in a larger risk of developing this rare neoplasia.

  5. Distribution of haemic neoplasia of soft-shelled clams in Prince Edward Island: an examination of anthropogenic factors and effects of experimental fungicide exposure.

    Science.gov (United States)

    Mateo, D R; MacCallum, G S; McGladdery, S E; Davidson, J

    2016-05-01

    Haemic neoplasia was first considered a disease of concern for soft-shell clams in Prince Edward Island (PEI) when it was diagnosed as the cause of mass mortalities in 1999. The aetiology of the disease remains elusive, but has been associated with environmental degradation. In this study, a 2-year (2001-2002) geographic and seasonal survey was conducted for haemic neoplasia, using histology, in soft-shell clams from PEI. In addition, using geographic information system, the association between anthropogenic factors in the watersheds at sites affected by haemic neoplasia and the prevalence of the disease was investigated. Finally, histopathological changes were assessed in soft-shell clams experimentally exposed to four concentrations of chlorothalonil for 27 days. Haemic neoplasia could not be induced at any concentration of chlorothalonil. Clams exposed to a concentration of 1000 μg L(-1) of the fungicide, however, exhibited an LC50 of 17 days. Although this information provides additional toxicity information (LC50) for soft-shell clams, further experiments are required to assess longer term exposure to the fungicide. The highest prevalences of haemic neoplasia in PEI were found in North River and Miscouche (28.3-50.9% and 33.0-77.8%, respectively). No clear seasonal patterns were found. There was a correlation between haemic neoplasia prevalence and watersheds with a high percentage of potato acreage and forest coverage (P = 0.026 and P = 0.045, respectively), suggesting a link between anthropogenic activity and the prevalence of the disease. © 2015 John Wiley & Sons Ltd.

  6. Early Diagnosis of Breast Cancer by Identifying Malignant Cells Within Neoplasias Histologically Classified as Benign

    National Research Council Canada - National Science Library

    Lelievre, Sophie A

    2005-01-01

    Current diagnostic tools permit the classification of breast neoplasias into categories that represent different relative risks of developing cancer, but they do not indicate which particular lesion...

  7. Differentiating between endocervical glandular neoplasia and high grade squamous intraepithelial lesions in endocervical crypts: cytological features in ThinPrep and SurePath cervical cytology samples.

    Science.gov (United States)

    Thiryayi, Sakinah A; Marshall, Janet; Rana, Durgesh N

    2009-05-01

    A recent audit at our institution revealed a higher number of cases diagnosed as endocervical glandular neoplasia on ThinPrep (TP) cervical cytology samples (9 cases) as opposed to SurePath (SP) (1 case), which on histology showed only high-grade cervical intraepithelial neoplasia (CIN) with endocervical crypt involvement (CI). We attempted to ascertain the reasons for this finding by reviewing the available slides of these cases, as well as slides of cases diagnosed as glandular neoplasia on cytology and histology; cases diagnosed as high-grade squamous intraepithelial lesions (HSIL) on cytology which had CIN with CI on histology and cases with mixed glandular and squamous abnormalities diagnosed both cytologically and histologically. Single neoplastic glandular cells and short pseudostratified strips were more prevalent in SP than TP with the cell clusters in glandular neoplasia 3-4 cells thick, in contrast to the dense crowded centre of cell groups in HSIL with CI. The cells at the periphery of groups can be misleading. Cases with HSIL and glandular neoplasia have a combination of the features of each entity in isolation. The diagnosis of glandular neoplasia remains challenging and conversion from conventional to liquid based cervical cytology requires a period of learning and adaptation, which can be facilitated by local audit and review of the cytology slides in cases with a cytology-histology mismatch. (c) 2009 Wiley-Liss, Inc.

  8. ¿Qué hacen los docentes en sus aulas? : El caso de un centro de Educación Primaria

    Directory of Open Access Journals (Sweden)

    Mónica Vallejo Ruiz

    2013-05-01

    Full Text Available El presente artículo describe la realidad de siete docentes de Educación Primaria en relación al uso de metodologías didácticas en sus aulas. Este estudio se centra en analizar las metodologías llevadas a cabo por docentes de Primaria para conocer el grado de implantación del modelo basado en competencias en este nivel educativo. La actualidad del tema y la falta de investigaciones en este nivel educativo motivan la realización de tal estudio. Concretamente, se trata de un estudio de caso de carácter descriptivo realizado en un centro de Educación Primaria en la Región de Murcia. Así, a través de entrevistas semiestructuradas, analizamos la práctica real de aula que emplean siete docentes –cinco mujeres y dos hombres de distintos niveles y especialidades–, para conocer cómo imparten sus clases. Las conclusiones apuntan a que los entrevistados aún no tienen asumido un modelo educativo basado en competencias, aunque se vislumbran indicios de una nueva reorientación de las metodologías empleadas y actividades desarrolladas con el objeto de la consecución de las ocho competencias básicas. Así, parece que los docentes se encuentran en un primer estadio de adaptación a la nueva concepción de los enfoques de enseñanza y aprendizaje.

  9. Programa para la ejecución de la reconfiguración de alimentadores de distribución primaria

    Directory of Open Access Journals (Sweden)

    Yoel R Rosales Hernández

    2011-02-01

    Full Text Available La reconfiguración en las redes de distribución primaria se ejecuta mediante la operación de interruptoresnormalmente abiertos y normalmente cerrados, manteniendo siempre una topología radial, y uno de susobjetivos es disminuir las pérdidas totales de la red donde se aplique. Se presenta un programa endesarrollo con una interfaz muy amigable y funciones que permiten calcular la reconfiguración óptima paraalcanzar el estado de pérdidas mínimas en cualquier circuito de distribución primaria modelado. Su algoritmode cálculo está basado en un método heurístico muy sencillo y atractivo para programar, el lenguaje deprogramación utilizado es el Borland Delphi versión 5. Este resultado puede constituir una útil herramientapara el estudio de las redes primarias durante su planificación y explotación.  The reconfiguration of primary distribution networks is run by means of normally open and normally closedswitches. It keeps radial topology and aims at lowering losses on the network where it is being run. Thispaper includes an undergoing program which has an interactive interface and functions enabling an optimumreconfiguration. This program allows to know the minimum losses at any represented primary distributioncircuit and may become a useful tool for the study of primary networks being planned or used. Its calculationalgorithm is based on an easy-to-program heuristic method. The programming language used was BorlandDelphi 5.

  10. INCIDÊNCIA E IMPORTÂNCIA DO DIAGNÓSTICO PRECOCE DE MELANOMA NO BRASIL

    Directory of Open Access Journals (Sweden)

    Matheus Violato Guidetti

    2016-10-01

    Full Text Available Embora o câncer de pele seja o mais frequente no Brasil e corresponda a 25% de todos os tumores malignos registrados no País, o melanoma representa apenas 4% das neoplasias malignas do órgão, porém é o tipo mais grave devido à sua alta possibilidade de metástase. Após uma comparação dos diversos estudos presentes nessa revisão, percebe–se determinada padronização no desenvolvimento da doença quanto ao sexo, idade, etnia e localização da lesão. No Brasil, essa neoplasia cresce anualmente e os fatores são diversos, como a pré-disposição genética e os maus cuidados com a pele, por isso, é fundamental trabalhar a conscientização sobre o risco dessa doença. Ademais, a incidência e prevalência do melanoma cutâneo carece de maior atenção das políticas públicas, pois o diagnóstico precoce é a chave-mestra para uma maior eficácia no tratamento.

  11. Manejo dos portadores das neoplasias intraepiteliais anais Managment of anal intra-epithelial neoplasia patients

    Directory of Open Access Journals (Sweden)

    Sidney Roberto Nadal

    2008-12-01

    Full Text Available Acredita-se que a neoplasia intraepitelial anal (NIA, provocada pelo HPV, seja a lesão precursora do carcinoma anal. Segundo a literatura, são encontradas entre 11% e 52% dos homens infectados pelo HIV, entre 6% a 20% dos homens e 1% a 2,8% das mulheres sem essa infecção. Entre 8,5% e 13% das NIA de alto grau evoluirão para carcinoma invasivo, indicando a necessidade do rastreamento e do seguimento desses doentes para prevenção. Não há tratamento satisfatório com baixos índices de morbidez e a recidiva é comum. Em geral, as formas de tratamento podem de ser divididas em tópicas, entre elas, ácido tricloroacético, podofilina, podofilotoxina, imiquimod, terapia fotodinâmica, e ablativas, ou seja, excisão cirúrgica, ablação pelo LASER, coagulação pelo infravermelho e eletrofulguração. Há, ainda, os que consideram aceitável a conduta expectante. O tratamento tópico se justifica pelo caráter multifocal da lesão e os ablativos têm taxas de complicação e recidiva muito semelhantes. De qualquer forma, doentes com qualquer anormalidade histológica necessitam de seguimento adequado, principalmente com colposcopia e citologia anal.Anal intra-epithelial neoplasia (AIN, provoked by HPV, is considered as an anal cancer precursor. Some articles noticed that it occurred among 11% and 52% of men who have sex with men (MSM infected with HIV and, among seronegatives, from 6% to 20% of men and from 1% to 2.8% of women. From 8.5% to 13% of high grade AIN will evolve to invasive carcinoma, needing follow-up and screening for prevention. There is no satisfactory treatment with low morbidity and recurrence is frequent. There are two main forms of treatment: topics (trichloroacetic acid, podophylin, podophylotoxin, imiquimod, photodynamic therapy and ablatives (chirurgical excision, LASER, infrared, eletrocautery. Others consider acceptable an expectant management. Topical therapy is justified because of multifocal presentation of HPV

  12. A rare presentation of multiple endocrine neoplasia (MEN type 2A syndrome

    Directory of Open Access Journals (Sweden)

    Elroy Patrick Weledji

    2016-02-01

    Full Text Available Peptic ulcer disease may be a manifestation of symptomatic primary hyperparathyroidism. A case of an intractable complicated peptic ulcer disease secondary to hypercalcaemia from multiple endocrine neoplasia type 2A is presented. Hypercalcaemia should always be excluded as a cause of recurrent, or complicated peptic ulcer disease.

  13. High-Resolution Anoscopy: Clinical Features of Anal Intraepithelial Neoplasia in HIV-positive Men

    NARCIS (Netherlands)

    Richel, Olivier; Hallensleben, Nora D. L.; Kreuter, Alexander; van Noesel, Carel J. M.; Prins, Jan M.; de Vries, Henry J. C.

    2013-01-01

    BACKGROUND: High-resolution anoscopy is increasingly advocated to screen HIV+ men who have sex with men for anal cancer and its precursor lesions, anal intraepithelial neoplasia. A systematic comparison between clinical features and the histopathology of suspect lesions is lacking. OBJECTIVE: This

  14. Prevalence of small-bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy

    NARCIS (Netherlands)

    Haanstra, Jasmijn F.; Al-Toma, Abdul; Dekker, Evelien; Vanhoutvin, Steven A. L. W.; Nagengast, Fokko M.; Mathus-Vliegen, Elisabeth M.; van Leerdam, Monique E.; Cappel, Wouter H. de Vos tot Nederveen; Sanduleanu, Silvia; Veenendaal, Roeland A.; Cats, Annemieke; Vasen, Hans F. A.; Kleibeuker, Jan H.; Koornstra, Jan J.

    2015-01-01

    Objective The aim was to determine the prevalence of small-bowel neoplasia in asymptomatic patients with Lynch syndrome (LS) by video capsule endoscopy (VCE). Design After obtaining informed consent, asymptomatic proven gene mutation carriers aged 3570 years were included in this prospective

  15. The negative association between a history of recurrent herpes labialis and cervical neoplasia

    NARCIS (Netherlands)

    Burger, M. P.; Wilterdink, J. B.

    1988-01-01

    We considered the possibility that herpetic recurrences and herpes virus associated neoplasia are mutually exclusive disorders because they are expressions of different herpes virus-host relationships. We assumed that the human body copes with orofacial and genital herpes infections in the same

  16. Endometrial Intraepithelial Neoplasia (EIN In An Endometrial Polyp

    Directory of Open Access Journals (Sweden)

    Devic Ana

    2015-12-01

    Full Text Available Endometrial intraepithelial neoplasia (EIN is a monoclonal neoplastic cell proliferation of the endometrium associated with a significantly increased risk of endometrioid endometrial adenocarcinoma. We herein present the case of a 58-year-old female patient who underwent a hysterectomy with bilateral salpingo-oophorectomy because of the existence of endometrial intraepithelial neoplasia in an endometrial polyp. The patient had irregular uterine bleeding, which lasted 10 days. An endometrial polyp was diagnosed by ultrasound examination. The polyp was located in the isthmus of the uterus, on the back wall, and measured 32 mm × 25 mm. The patient underwent fractional dilation and curettage, and the specimens were subjected to a histopathological examination. The histopathological findings were EIN, endometrioid type, a focus of which was found within the endometrial polyps, as well as the endometrial polyp and proliferative endometrium. The endocervical tissue was normal. Given the age of the patient and the histopathological findings, she underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy. The final histopathological findings were EIN, endometrioid type with a focus found within the endometrial polyp; endometrial polyp; simple hyperplasia; chronic inflammation of the uterine cervix; hyperkeratosis of the cervical squamous epithelium; and cervicitis chronica. There was also hydrosalpinx of the left fallopian tube, and cystic follicles in the left ovary. There was no significant morphological change in the right ovary or fallopian tube. The surgical and postoperative course were normal. The patient was sent home on the fifth postoperative day in good general condition. A check-up performed one month after surgery showed normal findings.

  17. Secuencia didáctica: Introducción a los significados clásico y frecuencial de la probabilidad para estudiantes de grado quinto de primaria

    OpenAIRE

    Velásquez Gómez, Mónica

    2014-01-01

    En este trabajo se plantea la propuesta de una secuencia didáctica para la enseñanza de la probabilidad en el grado quinto de primaria. En el documento se incluye una revisión de los significados de la probabilidad, obstáculos en el uso de conceptos probabilísticos, coherencia y pertinencia con los lineamientos curriculares y un breve análisis de los conocimientos previos de un grupo de estudiantes del grado quinto de primaria. En el documento se describe el proceso de construcción de la ...

  18. Documento de consenso sobre el abordaje de la enfermedad de Chagas en atención primaria de salud de áreas no endémicas

    Directory of Open Access Journals (Sweden)

    Carme Roca Saumell

    2015-05-01

    Se han elaborado guías de detección de Trypanosoma cruzi en circunstancias específicas (bancos de sangre, maternidades, coinfección con el VIH, trasplante de órganos; pero detectamos falta de información dirigida a los profesionales de atención primaria. Para facilitar la detección y manejo de esta enfermedad se consideró la necesidad de realizar este documento, redactado y consensuado por médicos de familia, pediatras de atención primaria y especialistas en salud internacional.

  19. Seguimiento de las recomendaciones en prevención secundaria cerebrovascular en atención primaria

    Directory of Open Access Journals (Sweden)

    Carmen Tamayo-Ojeda

    2017-06-01

    Conclusiones: El seguimiento de las recomendaciones de las guías clínicas para la prevención de la enfermedad cerebrovascular en atención primaria es mejorable, especialmente en los más jóvenes. Son necesarios cambios organizativos e intervención más activa de los profesionales, así como estrategias para combatir la inercia terapéutica.

  20. Web 2.0 y herramientas en red para Educación Infantil y Primaria

    OpenAIRE

    Solano Fernández, Isabel Mª

    2010-01-01

    Documento sobre Web 2.0 y herramientas y recursos para Eduación Infantil y Primaria, en el que se hace un recorrido por los términos Web 1.0, Web 2.0 y Web 3.0, y se presentan diversos recursos a partir de diferentes categorías: en función de las variables espacio-temporales, del sistema simbólico y la función. Ejercicios prácticos

  1. Levels of oxidative damage and lipid peroxidation in thyroid neoplasia.

    LENUS (Irish Health Repository)

    Young, Orla

    2012-02-01

    BACKGROUND: This study assessed the presence of oxidative damage and lipid peroxidation in thyroid neoplasia. METHODS: Using tissue microarrays and immunohistochemistry, we assessed levels of DNA damage (8-oxo-dG) and lipid peroxidation (4-HNE) in 71 follicular thyroid adenoma (FTA), 45 papillary thyroid carcinoma (PTC), and 17 follicular thyroid carcinoma (FTC) and matched normal thyroid tissue. RESULTS: Cytoplasmic 8-oxo-dG and 4-HNE expression was significantly higher in FTA, FTC, and PTC tissue compared to matched normal tissue (all p values < .001). Similarly, elevated nuclear levels of 8-oxo-dG were seen in all in FTA, FTC, and PTC tissue compared to matched normal (p values < .07, < .001, < .001, respectively). In contrast, a higher level of 4-HNE expression was detected in normal thyroid tissue compared with matched tumor tissue (p < .001 for all groups). Comparing all 3 groups, 4-HNE levels were higher than 8-oxo-dG levels (p < .001 for all groups) except that cytoplasmic levels of 8-oxo-dG were higher than 4-HNE in all (p < .001). These results were independent of proliferation status. CONCLUSION: High levels of DNA damage and lipid peroxidation in benign and malignant thyroid neoplasia indicates this damage is an early event that may influence disease progression.

  2. Diagnosis of Retrobulbar Round Cell Neoplasia in a Macaroni Penguin ( Eudyptes chrysolophus ) Through Use of Computed Tomography.

    Science.gov (United States)

    Woodhouse, Sarah J; Rose, Michelle; Desjardins, Danielle R; Agnew, Dalen W

    2015-03-01

    A 25-year-old female macaroni penguin (Eudyptes chrysolophus) was diagnosed with exophthalmos secondary to retrobulbar neoplasia through use of computed tomography (CT). Histopathologic examination of the mass supported a diagnosis of malignant round cell neoplasia. Immunohistochemical (IHC) labeling was applied to determine cell origin; the neoplastic cells did not label with T-cell marker CD3 or B-cell marker BLA.36 and could not be further characterized. The scleral ossicles precluded evaluation of the retrobulbar space by ultrasonography; therefore, CT scanning is recommended for examination of intraorbital structures in penguin and other avian species.

  3. La formación de maestros para la enseñanza primaria en Cuba y los programas literarios en sus planes de estudio

    Directory of Open Access Journals (Sweden)

    Mercedes Rodríguez Menéndez

    2017-11-01

    Full Text Available En Cuba la enseñanza primaria o elemental transitó por diferentes etapas donde adquirió rasgos específicos en correspondencia con los intereses gubernamentales y el desarrollo del sistema educativo. En este artículo se muestran las particularidades que va adquiriendo esta enseñanza atendiendo a dos etapas bien diferenciadas, cómo transcurre el proceso de formación de maestros en cada una de ellas y la evolución histórica del proceso de enseñanza aprendizaje de la literatura en la formación de los estudiantes de la carrera Licenciatura en Educación Primaria.

  4. Prevalence of small-bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy

    NARCIS (Netherlands)

    Haanstra, Jasmijn F.; Al-Toma, Abdul; Dekker, Evelien; Vanhoutvin, Steven A. L. W.; Nagengast, Fokko M.; Mathus-Vliegen, Elisabeth M.; van Leerdam, Monique E.; de Vos tot Nederveen Cappel, Wouter H.; Sanduleanu, Silvia; Veenendaal, Roeland A.; Cats, Annemieke; Vasen, Hans F. A.; Kleibeuker, Jan H.; Koornstra, Jan J.

    2015-01-01

    The aim was to determine the prevalence of small-bowel neoplasia in asymptomatic patients with Lynch syndrome (LS) by video capsule endoscopy (VCE). After obtaining informed consent, asymptomatic proven gene mutation carriers aged 35-70 years were included in this prospective multicentre study in

  5. Endoscopic Tri-Modal Imaging (ETMI With Optical Magnification in the Detection of Barrett's Early Neoplasia

    Directory of Open Access Journals (Sweden)

    Sarmed S. Sami

    2014-01-01

    Full Text Available Early lesion detection and characterisation is vital to ensure accurate management in patients with gastrointestinal neoplasia. Endoscopic Tri-modal Imaging (ETMI technology has been shown to improve the targeted detection of early dysplastic lesions in Barrett's Oesophagus, but these results were not confirmed in non-expert hands [1]. This technology incorporates high resolution while light endoscopy (HRE, Auto Fluorescence Imaging (AFI and Narrow Band Imaging (NBI in one endoscope. The mucosa is first inspected with HRE, and then AFI is switched on to help in highlighting any suspicious areas in the mucosa [2]. These areas can be further examined by switching to NBI mode with magnification which helps to characterise mucosal patterns and identify early neoplasia [3].

  6. Tumores de glándulas salivales: Su comportamiento en 10 años de trabajo (1993-2002

    Directory of Open Access Journals (Sweden)

    Oscar García-Roco Pérez

    2003-12-01

    Full Text Available Se realizó un estudio descriptivo de 107 pacientes que fueron intervenidos quirúrgicamente debido a afecciones en glándulas salivales, durante un período de 10 años, en el Servicio de Cirugía Maxilofacial del Hospital Provincial Docente "Manuel Ascunce Domenech" de Camagüey, con el propósito de describir su frecuencia según edad y sexo, comportamiento biológico, localización anatómica y resultado histopatológico. Hubo predominio de las condiciones neoplásicas benignas en la parótida, mientras que en la submandibular se manifestaron con mayor frecuencia los procesos malignos. El adenoma pleomorfo fue el tumor más frecuente entre las neoplasias benignas y el carcinoma mucoepidermoide, el más común entre las malignas.A descriptive study of 107 patients, who had been surgically treated from salivary gland tumors in the Maxillofacial Surgery Department of "Manuel Ascunce Domenech" provincial teaching hospital located in Camagüey during 10 years, was performed to describe the sex and age distribution and frequency of these tumors, their biological behavior, anatomical location and histopathological outcome. It was observed that benign neoplasias predominated in the parotid glands whereas malignant processes developed more often in submandibular glands. Pleomorphic adenoma was the most found tumor among the benign neoplasias and mucoepidermoid carcinoma was the commonest among the malignant processes.

  7. Síndrome de Sweet asociado a neoplasias Sweet's syndrome associated with neoplasms

    Directory of Open Access Journals (Sweden)

    Mariana Franco

    2006-10-01

    Full Text Available El síndrome de Sweet fue descrito en el año 1964 por Robert Douglas Sweet, como una entidad a la cual denominó dermatosis neutrofílica febril y aguda. Se caracteriza por cinco rasgos principales: 1 aparición brusca de placas eritemato-dolorosas en cara, cuello y extremidades; 2 fiebre; 3 leucocitosis polimorfonuclear; 4 denso infiltrado dérmico a predominio neutrofilico; 5 rápida respuesta al tratamiento esteroideo. Se puede clasificar en cinco grupos: idiopático, parainflamatorio, paraneoplásico, secundario a drogas y asociado a embarazo. En el 20% de los casos se asocia a enfermedades malignas, representando las hematológicas el 85% y los tumores sólidos el 15% restante. Se presenta una serie de siete casos de síndrome de Sweet asociado a neoplasias, diagnosticados durante el período 2002-2006, de los cuales seis correspondieron a enfermedades oncohematológicas y el restante a tumores sólidos. Como comentario de dicha casuística, se hace hincapié en la importancia del diagnóstico de este síndrome, debido a que puede anunciar la recaída del tumor o la progresión de la enfermedad de base. De esta manera, mediante el uso de métodos de diagnóstico y tratamiento oportunos, se lograría mejorar la calida de vida de estos pacientes. También debe tenerse en cuenta, que los pacientes oncológicos reciben múltiples medicaciones (factor estimulante de colonias, que pueden estar implicadas en la aparición de esta entidad, debiendo ser las mismas descartadas como posibles causas.Sweet's syndrome was described in 1964 by Robert Douglas Sweet, as an entity he named acute febrile neutrophilic dermatosis. It is characterized by five main features: 1 sudden appearance of erythematous and tender plaques on the face, neck and extremities; 2 fever; 3 polymorphonuclear leukocytes; 4 predominantly neutrophilic dense infiltrate in the dermis, and 5 rapid response to steroid therapy. Sweet's syndrome can be classified into five groups

  8. No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia

    DEFF Research Database (Denmark)

    Raitila, A; Georgitsi, M; Karhu, A

    2007-01-01

    . Here, we have analyzed 32 pituitary adenomas and 79 other tumors of the endocrine system for somatic AIP mutations by direct sequencing. No somatic mutations were identified. However, two out of nine patients with prolactin-producing adenoma were shown to harbor a Finnish founder mutation (Q14X...... as non-secreting pituitary adenomas have been reported, most mutation-positive patients have had growth hormone-producing adenomas diagnosed at relatively young age. Pituitary adenomas are also component tumors of some familial endocrine neoplasia syndromes such as multiple endocrine neoplasia type 1...... (MEN1) and Carney complex (CNC). Genes underlying MEN1 and CNC are rarely mutated in sporadic pituitary adenomas, but more often in other lesions contributing to these two syndromes. Thus far, the occurrence of somatic AIP mutations has not been studied in endocrine tumors other than pituitary adenomas...

  9. 2006 Bethesda International Consensus recommendations on the immunophenotypic analysis of hematolymphoid neoplasia by flow cytometry: optimal reagents and reporting for the flow cytometric diagnosis of hematopoietic neoplasia.

    Science.gov (United States)

    Wood, Brent L; Arroz, Maria; Barnett, David; DiGiuseppe, Joseph; Greig, Bruce; Kussick, Steven J; Oldaker, Teri; Shenkin, Mark; Stone, Elizabeth; Wallace, Paul

    2007-01-01

    Immunophenotyping by flow cytometry has become standard practice in the evaluation and monitoring of patients with hematopoietic neoplasia. However, despite its widespread use, considerable variability continues to exist in the reagents used for evaluation and the format in which results are reported. As part of the 2006 Bethesda Consensus conference, a committee was formed to attempt to define a consensus set of reagents suitable for general use in the diagnosis and monitoring of hematopoietic neoplasms. The committee included laboratory professionals from private, public, and university hospitals as well as large reference laboratories that routinely operate clinical flow cytometry laboratories with an emphasis on lymphoma and leukemia immunophenotyping. A survey of participants successfully identified the cell lineage(s) to be evaluated for each of a variety of specific medical indications and defined a set of consensus reagents suitable for the initial evaluation of each cell lineage. Elements to be included in the reporting of clinical flow cytometric results for leukemia and lymphoma evaluation were also refined and are comprehensively listed. The 2006 Bethesda Consensus conference represents the first successful attempt to define a set of consensus reagents suitable for the initial evaluation of hematopoietic neoplasia. Copyright 2007 Clinical Cytometry Society.

  10. Diagnóstico Molecular y Genético de Inmunodeficiencias Primarias ligadas al X

    OpenAIRE

    Martínez Martínez, Laura

    2011-01-01

    Las Inmunodeficiencias Primarias (IDPs) son enfermedades congénitas del sistema inmune que tienen en común una susceptibilidad incrementada a las infecciones. Se han descrito más de 200 entidades englobadas bajo esta definición. Algunas de ellas tienen una herencia ligada al X, lo que les confiere ciertas peculiaridades. En esta Tesis presentamos los resultados concernientes a 28 pacientes, casi todos varones, con sospecha de IDP en base a una elevada frecuencia y severidad de ...

  11. Estacionalidad e impacto del turismo en la atención urgente hospitalaria y primaria

    OpenAIRE

    Mateu Sbert, Josep

    2015-01-01

    Los servicios de urgencias médicas hospitalarios y de atención primaria son considerados claves en el funcionamiento del sistema sanitario. Modelizar el comportamiento temporal de las visitas urgentes es fundamental para planificar adecuadamente su demanda, especialmente en aquellas regiones donde se producen altas oscilaciones estacionales de población. El objetivo de esta tesis doctoral es estimar el impacto del turismo sobre las series de urgencias médicas de titularidad pública, tanto de ...

  12. Optical Molecular Imaging of Epidermal Growth Factor Receptor Expression to Improve Detection of Oral Neoplasia

    Directory of Open Access Journals (Sweden)

    Nitin Nitin

    2009-06-01

    Full Text Available Background: The development of noninvasive molecular imaging approaches has the potential to improve management of cancer. Methods: In this study, we demonstrate the potential of noninvasive topical delivery of an epidermal growth factor-Alexa 647 (EGF-Alexa 647 conjugate to image changes in epidermal growth factor receptor expression associated with oral neoplasia. We report a series of preclinical analyses to evaluate the optical contrast achieved after topical delivery of EGF-Alexa 647 in a variety of model systems, including cells, three-dimensional tissue cultures, and intact human tissue specimens using wide-field and high-resolution fluorescence imaging. Data were collected from 17 different oral cancer patients: eight pairs of normal and abnormal biopsies and nine resected tumors were examined. Results: The EGF-dye conjugate can be uniformly delivered throughout the oral epithelium with a penetration depth exceeding 500 µm and incubation time of less than 30 minutes. After EGF-Alexa 647 incubation, the presence of oral neoplasia is associated with a 1.5- to 6.9-fold increase in fluorescence contrast compared with grossly normal mucosa from the same patient with both wide-field and high-resolution fluorescence imaging. Conclusions: Results illustrate the potential of EGF-targeted fluorescent agents for in vivo molecular imaging, a technique that may aid in the diagnosis and characterization of oral neoplasia and allow real-time detection of tumor margins.

  13. Health-Related Quality of Life and Sexual Functioning of HIV-Positive Men Who Have Sex With Men Who Are Treated for Anal Intraepithelial Neoplasia

    NARCIS (Netherlands)

    Siegenbeek van Heukelom, Matthijs L.; Richel, Olivier; Nieuwkerk, Pythia T.; de Vries, Henry J. C.; Prins, Jan M.

    2016-01-01

    The impact of the treatment of precursor lesions of anal cancer (anal intraepithelial neoplasia) on health-related quality of life has not been investigated. This study aimed to evaluate the impact of 3 treatment options for anal intraepithelial neoplasia on health-related quality of life and sexual

  14. Acantosis Nigricans Maligna Acanthosis Nigricans Maligna

    Directory of Open Access Journals (Sweden)

    C Vallejo

    2011-06-01

    Full Text Available Es un síndrome paraneoplásico poco común, que se asocia a tumores gastrointestinales, más frecuentemente a adenocarcinoma gástrico (69%. Afecta a ambos sexos y no tiene prevalencia por grupo étnico alguno. Clínicamente son lesiones hiperpigmentadas, hipertróficas y verrucosas en zonas de flexión y en la mayoría de los casos, las mucosas también resultan afectadas con lesiones papilomatosas. Habitualmente desaparecen con la eliminación del tumor o reaparecen con la recurrencia o metástasis.Acanthosis nigricans malignant is an uncommon paraneoplastic syndrome associated with gastrointestinal tumors, frequently gastric adenocarcinoma, affects both sexes and it has not prevalence by race. Clinically, lesions are hyperpigmented, hypertrophic and verrucous in flexion areas and in most cases the mucous membranes are also affected with papillomatous lesions. Tipically disappears with the removal of the tumor and reappears when recurrence or metastasis occur.

  15. El campesinado gallego y su rechazo a la escuela primaria (1868-1874

    Directory of Open Access Journals (Sweden)

    Mercedes SUÁREZ PAZOS

    2010-03-01

    Full Text Available RESUMEN: Con la nueva política de descentralización educativa, nacida al amparo de la «revolución» de septiembre de 1868, los Ayuntamientos y las Juntas locales de Instrucción Primaria fueron responsables directos de numerosas supresiones de escuelas en el ámbito rural gallego y de los graves problemas que se ocasionaban en el pago de las dotaciones escolares: supresiones, reducciones y atrasos, a pesar de que tales modificaciones no se podían llevar a cabo sin la aprobación de la respectiva Diputación provincial.

  16. La toxicología en la atención primaria de salud

    Directory of Open Access Journals (Sweden)

    Jesús Martínez Cabrera

    1995-06-01

    Full Text Available Se expone la función que debe desempeñar la toxicología en Cuba para contribuir al logro de la meta de Salud para todos en el año 2000, así como los factores que condicionan el surgimiento de la toxicología preventiva. Se expresan los principales elementos que debe conocer el médico de la familia sobre toxicología y la necesidad de ampliar la interacción en el terreno docente, asistencial e investigativo entre la toxicología y el nivel de atención primaria de salud.

  17. La importancia de evitar expectativas negativas y potenciar la autoestima en primaria.

    OpenAIRE

    Sarabia-López, Jessica María

    2014-01-01

    En los estudios de Rosenthal y Jacobson (1968), se afirmó que el rendimiento académico de los alumnos depende de las creencias y expectativas que el profesor tenga de él, y a su vez éstas dependen de la autoestima que el maestro posea y transmita a sus alumnos. En este trabajo, se pretende fomentar la autoestima a maestros y alumnos, haciendo partícipe a las familias, mediante la elaboración de una propuesta de intervención dirigida a los alumnos del aula de 1º de Educación Primaria. Previo a...

  18. Perfil socioeconômico de Trabalhadores Rurais portadores de neoplasia Socioeconomic profile of Rural Workers cancer sufferers

    Directory of Open Access Journals (Sweden)

    Adrielle Chermont da Silva

    2016-07-01

    Full Text Available Objetivo: Traçar o perfil socioeconômico dos trabalhadores rurais portadores de neoplasia internados em um hospital universitário. Método: estudo do tipo descritivo com abordagem quantitativa, realizado entre agosto de 2013 a janeiro de 2014, através de busca nos prontuários e busca ativa por pacientes internados e que estivessem dentro dos critérios de inclusão. Os dados foram analisados por meio de estatística descritiva. Resultados: Foram entrevistados 59 trabalhadores rurais, advindos de diferentes municípios interioranos, que trabalhavam com variados tipos de cultivos agrícolas. Grande parcela dos entrevistados relatou fazer uso de agrotóxicos, não utilizando EPI. O tipo predominante de neoplasia encontrada foram as neoplasias do sistema digestório. Conclusões: o uso de agrotóxicos é uma realidade para os trabalhadores investigados, levando à exposição a riscos ocupacionais. Os trabalhadores da saúde necessitam implementar estratégias de atenção à saúde desses trabalhadores, no intuito de auxiliar na minimização dos riscos de exposição ocupacional aos agrotóxicos.

  19. Dificultades para la escritura en alumnos de 3º de educación primaria: la disgrafía y las pruebas de diagnóstico.

    OpenAIRE

    Pérez Fernández, Rebeca

    2015-01-01

    RESUMEN: En el presente trabajo se describen los diferentes métodos, recursos y estrategias que se pueden utilizar para el tratamiento de la disgrafía desde un aula de Educación Primaria. Concretamente, se indica cómo se trata este error orientado a las pruebas de diagnóstico llevadas a cabo en un aula específica de 3º de Primaria. La disgrafía es una de las dificultades específicas relacionadas con la escritura y puede ser reconocida desde los primeros años de escolarización, lo que nos hace...

  20. Comprensión lectora y resolución de problemas en estudiantes de Educación Primaria Bilingüe en comunidades shipibas

    Directory of Open Access Journals (Sweden)

    Dulio Oseda Gago

    2014-12-01

    Full Text Available Objetivos: Determinar la relación entre la comprensión lectora y la resolución de problemas en estudiantes del sexto grado de educación primaria bilingüe de las comunidades shipibas del distrito de Yarinacocha, Ucayali en el 2014. Métodos: Investigación de enfoque cuantitativo, tipo básica, diseño descriptivo - correlacional. La muestra fue tomada probabilísticamente conformada por 56 estudiantes del sexto grado de Educación Primaria Bilingüe en las comunidades shipibas del distrito de Yarinacocha el cual se determinó con un nivel de significancia del 5 %. Según el diseño, se utilizó los estadígrafos de la estadística descriptiva e inferencial, para contrastar la hipótesis se hizo uso de la prueba r de Pearson y la t de Student, que nos permitió deducir que existe una correlación directa y significativa (r=0,592. Resultados: La significancia obtenida (0,003 resultó inferior al nivel de significación propuesta (α = 0,05 por lo que se decide rechazar la hipótesis nula, afirmando que en términos generales, existe relación directa y significativa entre la comprensión lectora y la resolución de problemas matemáticos en los estudiantes del sexto grado de Educación Primaria Bilingüe evaluados en las comunidades Shipibas del distrito de Yarinacocha. Conclusiones: Se afirma que existe una relación directa entre la comprensión lectora y la resolución de problemas en estudiantes del sexto grado de Educación Primaria Bilingüe en las comunidades shipibas del distrito de Yarinacocha, 2014.

  1. EXPRESSION OF HPV 16 AND 18 IN CERVICAL INTRAEPITHELIAL NEOPLASIA

    OpenAIRE

    Kodali Venkataramana; Prasad Usha

    2017-01-01

    BACKGROUND Cervical cancer is by far the most common human papilloma virus related disease. Nearly, all cases of cervical cancer can be attributable to human papilloma virus infection. Infection with the human papilloma virus is the main risk factors for cervical intraepithelial neoplasia and cervical cancer especially the high-risk types. The aim of the study is to study the prevalence of high-risk human papilloma virus 16 and 18 in various grades of cervical intraepithelia...

  2. Citometria de fluxo no cancro do pulmão. Eficácia da citologia como técnica de selecção dos espécimes a processar

    Directory of Open Access Journals (Sweden)

    V. Hespanhol

    1995-11-01

    Full Text Available RESUMO: O cancro do pulmão é a neoplasia mais frequente no sexo masculino nos países da U.E., mostrando actualmente tendência crescente em todos os países. O cancro do pulmão é a maior causa de morte por neoplasia, tanto na E.U. como nos E.U.A. A sobrevida é geralmente curta, sendo a maioria dos doentes diagnosticados em fases avançadas da doença, dificultando a decisão terapêutica. Para estabelecer a opção terapêutica há necessidade de conhecimento mais aprofundado dos factores que podem influenciar a sobrevida, não só relativos ao doente, mas também em relação ao próprio tumor.O presente estudo insere-se numa avaliação prognóstica global, incluindo características do doente e do tumor. Na avaliação das características do tumor utilizamos citometria de fluxo (FCM que permite avaliar o conteúdo e o índice do ADN e a fracção de cálulas em Fase-S. As amostras a processar são colhidas por técnicas diagnósticas (biopsia, escovagem e lavagem brônquicas, biopsia aspirativa transtorácica - BAT e aspirado ganglionar, sendo utilizado no processamento o material restante, após ter sido obtido o diagnóstico. Pretendemos nesta investigação preliminar definir um controlo de qualidade dos espécimes a processar por FCM em relação à presença ou não de células neoplásicas, atravás de um rastreio citológico. Por outro lado, verificar se é exequível utilizando amostras tão exíguas obter resultados de FCM fláveis. Estudámos 78 doentes suspeitos de terem neoplasia maligna do pulmão. Só nos 43 em que se provou existir neoplasia maligna se procedeu á realização de FCM. Obtivemos resultados avaliáveis de FCM em 62% (27/43. As técnicas de colheita mais reotáveis, após rastreio citológico, foram a biopsia brônquica (76% e a escovagem brônquica (100%. Encontramos uma deficiente rentabilidade utilizando a BAT (31%. A citologia é um bom método de selecção para espécimes colhidos por biopsia br

  3. Diagnóstico fenotípico de las inmunodeficiencias primarias en Antioquia, Colombia, 1994-2002.

    Directory of Open Access Journals (Sweden)

    Carlos Julio Montoya

    2002-12-01

    Full Text Available La infección recurrente es una causa frecuente de consulta médica y puede deberse a un grupo heterogéneo de trastornos que incrementan la susceptibilidad a los microorganismos patógenos y oportunistas, como las deficiencias inmunológicas subyacentes. Con el fin de definir un tratamiento racional oportuno y orientar el diagnóstico molecular de las inmunodeficiencias primarias, se estableció un programa para el diagnóstico fenotípico de estas enfermedades en el departamento de Antioquia (Colombia, que comprende un análisis clínico y de laboratorio de los individuos que presentan infecciones recurrentes de evolución anormal. Entre el 1 de agosto de 1994 y el 31 de julio de 2002 se hizo el diagnóstico fenotípico de inmunodeficiencia primaria en 98 pacientes. Similar a lo informado en la literatura especializada, en esta región las deficiencias predominantes de anticuerpos fueron las más frecuentes (40,8% seguidas por las deficiencias combinadas (21,4%. Esta caracterización fenotípica ha permitido iniciar rápidamente el tratamiento adecuado y, en algunos casos, comenzar los estudios funcionales y moleculares que conduzcan al diagnóstico molecular definitivo.

  4. Metastização pulmonar de neoplasia da mama

    Directory of Open Access Journals (Sweden)

    Jorge Dionísio

    2002-03-01

    Full Text Available RESUMO: Para caracterizar os doentes com metastização pulmonar de neoplasia da mama, procedemos a um estudo retrospectivo dos processos de 129 doentes referenciados à Unidade de Pneumologia entre Julho de 1990 e Janeiro de 2000.Foi considerada a existência de metastização pulmonar em 89 casos.Avaliámos as manifestações clínicas apresentadas, o intervalo de tempo até ao diagnóstico de metastização pulmonar, os aspectos radiológicos, endoscópicos, as terapêuticas efectuadas e a sobrevida.O intervalo médio entre o diagnóstico da neoplasia da mama e o diagnóstico de metastização pulmonar foi de 81,9±5,7 meses. Os sintomas respiratórios foram referidos em 83,1% dos doentes. O padrão radiológico mais comum foi a presença de massas ou nódulos pulmonares (66,3%. Foram observadas 49 com sinais directos de neoplasia na broncofibroscopia. Em 47 os aspectos anatomopatológicos encontrados foram compatíveis com metastização endobrônquica de tumor da mamaO tratamento mais frequentemente utilizado após o diagnóstico de metástase pulmonar foi a quimioterapia, em 60,2% dos casos.Após o diagnóstico de metastização, a sobrevida mediana foi de 20,1 meses, com 63,4% dos doentes vivos ao fim de 1 ano.Nos doentes com carcinoma da mama e suspeita de metastização verificámos um grande intervalo livre entre o diagnóstico do tumor da mama e o aparecimento de metastização. Os sintomas respiratórios tra-duziram a grande frequência de envolvimento endobrônquico. O diagnóstico anatomopatológico de metastização pulmonar foi obtido em 52,8% dos doentes. A terapêutica mais utilizada após diagnóstico de metastização foi a quimioterapia e a sobrevida ao ano foi de 63,4%.REV PORT PNEUMOL 2002; VIII (2: ABSTRACT: We performed a retrospective study of 129 patients observed in Pneumology unit between July 1990 and January 2000 to evaluate the clinical, radiological and endoscopic patterns as well as the clinical evolution of

  5. Manejo de las adolescentes con neoplasia intraepitelial cervical

    OpenAIRE

    Martínez Chang, Ysis Margarita; Sarduy Nápoles, Miguel

    2006-01-01

    Se realizó un estudio descriptivo en pacientes adolescentes que acudieron a la consulta de patología de cuello del Hospital “Ramón González Coro” en el período comprendido de enero de 2003 a mayo de 2005. El número de pacientes atendidas ascendió a 144 y de ellas 32 presentaron neoplasia intraepitelial cervical. El grupo de edades más frecuente resultó el comprendido entre 17 y 18 años, con una frecuencia referida entre 2 y 3 parejas sexuales. La infección de transmisión sexual más común fue ...

  6. MANIFESTACIONES DE LA VIOLENCIA PERVERSA EN ESCUELAS PRIMARIAS DEL NORESTE DE MÉXICO

    OpenAIRE

    Jesús Acevedo Alemán; José González Tovar

    2015-01-01

    El objetivo de este estudio fue identificar la estructura de las prácticas de la llamada “violen-cia perversa” en 54 escuelas primarias del noreste de México, particularmente de la ciudad deSaltillo, Coahuila. La muestra intencional estuvo compuesta por 529 niños con edades de 5 a13 años. El instrumento utilizado fue la Cédula de Percepciones de las Dinámicas Escolares,el cual está integrado por 78 reactivos, de los cuales se generaron inicialmente dos factores:impresiones de un mundo pervers...

  7. TRANSFERENCIA DE INTELIGENCIAS MÚLTIPLES EN ALUMNOS CON AUTISMO DE EDUCACIÓN PRIMARIA

    OpenAIRE

    Plágaro-Martos, Miriam

    2015-01-01

    El presente estudio de investigación está basado en la Teoría de la Inteligencias Múltiples, descrita por Howard Gardner en 1983. Así como en el concepto de inteligencia emocional, acuñado por Daniel Goleman en 1995. Estudiamos el nivel de desarrollo en cada inteligencia múltiple, en alumnos diagnosticados con Trastorno de Espectro Autista, autismo. Componiéndose la muestra de estudio por 30 alumnos con dicho diagnóstico, escolarizados en la etapa educativa de educación primaria. Para el desa...

  8. Melanoma en la región de cabeza y cuello

    Directory of Open Access Journals (Sweden)

    Francisco Avello Canisto

    2015-04-01

    Full Text Available El melanoma es una neoplasia maligna producto de la degeneración y atipia del melanocito (célula formadora del pigmento melanina. Al melanocito lo encontramos en la piel (capa basal de la epidermis, globo ocular (membrana coroidea y sistema nervioso central (piamadre. La localización en cabeza y cuello, representa el 30% de todos los melanomas en general, después de las extremidades inferiores y superiores, y más de las dos terceras partes se localizan en la piel de la cara. Menos frecuente es su origen en las membranas mucosas (fosas nasales, cavidad oral, conjuntivas, donde generalmente carece de melanina. Hay casos reportados de melanoma intraocular y de glándula salival submaxilar, pero su presentación es muy rara.

  9. Risk of cervical cancer after completed post-treatment follow-up of cervical intraepithelial neoplasia

    DEFF Research Database (Denmark)

    Rebolj, Matejka; Helmerhorst, Theo; Habbema, Dik

    2012-01-01

    To compare the risk of cervical cancer in women with histologically confirmed cervical intraepithelial neoplasia who returned to routine screening after having completed post-treatment follow-up with consecutive normal smear test results with women with a normal primary smear test result....

  10. Alfabetización en salud en pacientes con insuficiencia cardiaca atendidos en atención primaria

    Directory of Open Access Journals (Sweden)

    Rosalia Santesmases-Masana

    2017-01-01

    Conclusiones: La alfabetización en salud permite explicar la actitud de los pacientes hacia el régimen terapéutico que requiere la insuficiencia cardiaca. En los pacientes con insuficiencia cardiaca, los médicos y enfermeras de atención primaria han de tener en cuenta los factores que facilitan la comprensión de la información de salud.

  11. Diagnóstico molecular y genético de inmunodeficiencias primarias ligadas al X

    OpenAIRE

    Martínez Martínez, Laura

    2012-01-01

    Descripció del recurs: el 01 setembre 2012 Las Inmunodeficiencias Primarias (IDPs) son enfermedades congénitas del sistema inmune que tienen en común una susceptibilidad incrementada a las infecciones. Se han descrito más de 200 entidades englobadas bajo esta definición. Algunas de ellas tienen una herencia ligada al X, lo que les confiere ciertas peculiaridades. En esta Tesis presentamos los resultados concernientes a 28 pacientes, casi todos varones, con sospecha de IDP en base a una ele...

  12. Incidência de mortalidade por câncer no Rio Grande do Sul, Brasil Cancer: incidente and mortality in Rio Grande do Sul - Brazil

    Directory of Open Access Journals (Sweden)

    Lucio Borges Barcelos

    1983-10-01

    Full Text Available Apresenta-se estudo dos casos e óbitos de câncer notificados à Unidade de Informática da Secretaria da Saúde e do Meio Ambiente do do Rio Grande do Sul, Brasil no ano de 1979. A distribuição etária da morbimortalidade apresentou tendência, acentuadamente crescente com a idade. No sexo masculino, as localizações anatômicas de maior mortalidade, em ordem decrescente, foram: traquéia, brônquios e pulmão; estômago; esôfago; próstata e leucemias. Na incidência repetiram-se as mesmas localizações com introdução da pele em segundo lugar e saída das leucemias. No sexo feminino, mama; estômago; útero, outras localizações especificadas e as não especificadas; traquéia, brônquios e pulmão; e colo do útero, foram as cinco primeiras localizações de maior mortalidade. As neoplasias malignas da mama foram as que apresentaram maior incidência. Seguiram-se as neoplasias malignas da pele, do colo do útero, das outras localizações especificadas e as não especificadas do útero e do estômago. A distribuição geográfica mostrou uma morbimortalidade maior na 1ª, 3ª, 7ª, 10ª e 13ª Delegacia Regional de Saúde, em regiões caracterizadas ou por um elevado índice de industrialização ou pela existência de grandes propriedades rurais onde é praticada a pecuária extensiva. Uma vez feita a padronização, as neoplasias malignas de esôfago e laringe, apresentaram-se com coeficientes elevados, superando, no caso do esôfago, os coeficientes de outros países.A study of the incidence of, and deaths from, cancer as reported to the Welfare Ministry of Rio Grande do Sul State, Brazil, in 1979, is presented. The distribution of morbimortality showed an accentuated increase with age. In males the anatomic sites associated with higher mortality were (in decreasing order: trachea, bronchi and lungs, stomach, esophagus, prostate and leukemias. In incidence related to the same sites, however, skin cancer moved into second place and

  13. Prescripción inadecuada en pacientes polimedicados mayores de 64 años en atención primaria

    Directory of Open Access Journals (Sweden)

    Josefina Filomena Paci

    2015-01-01

    Conclusiones: La PI en los pacientes polimedicados en atención primaria fue muy elevada. La PI fue similar respecto a fármacos que se deberían retirar o se deberían iniciar. Las causas más frecuentes de PI fueron antiagregantes, benzodiacepinas y duplicidades farmacológicas.

  14. Photodynamic therapy of cervical intraepithelial neoplasia

    Science.gov (United States)

    Inada, Natalia M.; Lombardi, Welington; Leite, Marieli F. M.; Trujillo, Jose R.; Kurachi, Cristina; Bagnato, Vanderlei S.

    2014-03-01

    Photodynamic therapy (PDT) is a technique that has been used for the treatment of tumors, especially in Gynecology. The photodynamic reaction is based on the production of reactive oxygen species after the activation of a photosensitizer. Advantages of the PDT in comparison to the surgical resection are: ambulatory treatment and tissue recovery highly satisfactory, through a non-invasive procedure. The cervical intraepithelial neoplasia (CIN) grades I and II presents potential indications for PDT. The aim of the proposed study is to evaluate the safety and efficacy of the PDT for the diagnostics and treatment of CIN I and II. The equipment and the photosensitizer are produced in Brazil with a representative low cost. It is possible to visualize the fluorescence of the cervix and to treat the lesions, without side effects. The proposed clinical protocol shows great potential to become a public health technique.

  15. Topical 5-fluorouracil treatment of anal intraepithelial neoplasia in human immunodeficiency virus-positive men

    NARCIS (Netherlands)

    Richel, O.; Wieland, U.; de Vries, H. J. C.; Brockmeyer, N. H.; van Noesel, C.; Potthoff, A.; Prins, J. M.; Kreuter, A.

    2010-01-01

    Background Anal intraepithelial neoplasia (AIN), a human papillomavirus (HPV) induced potential precursor lesion of anal cancer, is frequent among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM). So far, only a few prospective studies have been performed on the topical

  16. Atención a la diversidad (autismo) a través de la literatura infantil en el aula de primaria

    OpenAIRE

    Trejo Malfaz, María de la Paz

    2014-01-01

    Intervención en el aula para sensibilizar en la inclusión educativa y la atención a la diversidad de los niños con autismo partiendo de un libro de literatura infantil. Grado de Educación Primaria

  17. Asociación entre las habilidades mentales primarias y el rendimiento académico en estudiantes de medicina de pregrado

    Directory of Open Access Journals (Sweden)

    Víctor Manuel Gómez-López

    2013-01-01

    Full Text Available Con el propósito de analizar la asociación que existe entre las habilidades mentales primarias cuando se ingresa a la carrera de medicina y el rendimiento académico cuando se termina el octavo semestre, se realizó un estudio observacional y retrospectivo en 121 egresados de la Licenciatura de Medicina de una escuela particular del norte de México. Las habilidades mentales primarias se consideraron como variables predictoras, en tanto el rendimiento académico se asumió como variables de resultado. El razonamiento y la comprensión verbal presentaron asociación estadísticamente significativa con el rendimiento académico, arrojando un valor de p = 0,013 y 0,029, respectivamente, por lo que podemos concluir que el rendimiento académico en estudiantes de medicina requiere principalmente del razonamiento y de la comprensión verbal.

  18. [Crossed renal ectopia in a patient with a complicated sigma neoplasia].

    Science.gov (United States)

    Pérez-Sánchez, Luis Eduardo; Burneo-Esteves, Mauricio; Rosat-Rodrigo, Adriá; Baz-Figueroa, Caleb; Pérez-Álvarez, Antonio Dámaso; Barrera-Gómez, Manuel Ángel

    2017-12-01

    Crossed renal ectopia is a rare pathology that is often asymptomatic. Intraoperative detection with a sigma complicated neoplasia is more infrequent and requires correct management to avoid a renal ureteral injury. To present a case report of a patient with a sigma complicated neoplasia and a crossed renal ectopia detected incidentally. We present the case of a 62-year-old man that was submitted for emergency surgery for a sigma perforated neoplasm, and who presented with a previously undiagnosed left-side CRE. During surgery there was a need to insert 2-double-J stents as a guide to both ureters and to avoid any injury to them. Crossed renal ectopia is a rare, often asymptomatic entity, the diagnosis of which is usually incidental. In our case, the detection of a concomitant complicated neoplasm, required identification of both ureters due the anatomic doubt of its localization and to avoid them being injured. In conclusion, upon finding a casual crossed renal ectopia during an emergency surgery of sigma, we recommend the identification of the ureters to facilitate its location and to avoid any injury to the ureters. Copyright © 2016 Academia Mexicana de Cirugía A.C. Publicado por Masson Doyma México S.A. All rights reserved.

  19. La informatización de la atención primaria de salud The informatization in primary health care

    Directory of Open Access Journals (Sweden)

    Rodolfo J. Stusser Beltranena

    2006-12-01

    Full Text Available La informatización de la atención primaria de salud se percibe como un problema que se soluciona creando redes computarizadas entre los consultorios y policlínicos. El artículo brinda una visión panorámica del estado en que se encuentra el arte de la informatización de la atención primaria y la medicina general integral, en el mundo y en Cuba. Para ello, se sintetiza el origen prehistórico de ese nivel de atención y de la especialidad, así como el desarrollo contemporáneo de la informática y sus aplicaciones médicas; se define igualmente la atención primaria y su informática; se resumen los sistemas de información, las aplicaciones informáticas y sus desafíos; y se ofrece una visión práctica de la historia clínica-electrónica: corazón de la informática de atención primaria de salud y medicina general integral. Se concluye que Cuba ha trabajado 20 años informatizando la dispensarización y estadísticas para la gerencia de servicios de este nivel de atención, pero que también podría trabajar con el enfoque centrado en la vida del paciente, que contribuiría a crear una clasificación integradora de la salud con la enfermedad, y a computarizar la información y la toma de decisiones clínicas en el consultorio del médico, y en el futuro hasta en el hogar del paciente, elevando directamente la calidad de la atención primaria de salud.The informatization in primary health care is perceived as problem that is solved by creating computer networks between the family physicians' offices and the polyclinics. This article gives a panoramic view of the state in which the art of informatization of primary health care and comprehensive general medicine is in the world and in Cuba. To this end, the prehistoric origin of this care level and of the specialty is synthezised, as well as the contemporary development of informatics and its medical applications. Primary care and its informatics is also defined, and the information

  20. Medida de innovaciones en escuelas de Educación Infantil y Primaria

    Directory of Open Access Journals (Sweden)

    Isabel Cantón Mayo

    2017-01-01

    Full Text Available La innovación es la clave de los avances en educación. Los centros educativos reali - zan innovaciones muy diversas con niveles de impacto y difusión muy bajos fuera de su comu - nidad. No existen muchos estudios que describan, pongan en valor las innovaciones, las cate - goricen y las analicen. La metodología de estudio fue descriptivo-interpretativa para lo que se elaboró un cuestionario denominado GINCENPRINF completado por 86 docentes de Educación Infantil y Primaria seleccionados por muestreo aleatorio estratificado (público-privado, rural-ur - bano. Se evaluó la fiabilidad y la validez de constructo del cuestionario y se determinó la validez de contenido mediante juicio de expertos. Los resultados revelaron una consistencia buena del cuestionario (Alfa de Cronbach: 0.848. Los resultados del análisis factorial confirman las dimen - siones propuestas en el diseño del cuestionario sobre las categorías de los factores incluidos en la innovación (cohesión social, interacción con la comunidad, Tecnologías, y éxito, las escuelas innovadoras y sus característica, el tema y el tipo de innovación (sobre recursos, dirección, mate - riales y tiempo, así como las resistencias a la innovación. Se realizaron los estadísticos descripti - vos y el análisis factorial por categorías. Se concluye que el cuestionario GINCENPRINF es válido y fiable para medir la gestión de las innovaciones en escuelas de Educación Infantil y Primaria.

  1. [Usefulness of human papillomavirus testing in anal intraepithelial neoplasia screening in a risk behaviour population].

    Science.gov (United States)

    Padilla-España, Laura; Repiso-Jiménez, Bosco; Fernández-Sánchez, Fernando; Frieyro-Elicegui, Marta; Fernández-Morano, Teresa; Pereda, Teresa; Rivas-Ruiz, Francisco; Redondo, Maximino; de-Troya Martín, Magdalena

    2014-11-01

    The incidence of intraepithelial anal neoplasia is increasing in certain risk behaviour groups, and human papillomavirus (HPV) infection is involved in its pathogenesis. The systematic use of anal cytology, and more recently HPV detection by hybrid capture and genotyping, have been introduced into screening programs in recent decades. A retrospective cohort study was carried out on individuals with risk behaviours of developing intraepithelial anal neoplasia and who attended Sexually Transmitted Infections clinics in the Dermatology area of the Hospital Costa del Sol from January 2010 to December 2012. The intraepithelial anal neoplasia screening was performed using anal cytology and HPV genotyping. Half (50%) of the study population were HIV positive. A high frequency of anal dysplasia and presence of HPV in cytology (82.1%) and genotype (79%) was found. A statistically significant association (P<.005) was obtained between the presence of high-risk HPV genotypes and the presence of high-grade dysplasia in the second directed cytology. HPV genotyping enabled 17 cases (22%) of severe dysplasia to be identified that were under-diagnosed in the first cytology. Cases of high-grade dysplasia can be under-diagnosed by a first anal cytology. Detection of HPV can supplement this procedure, leading to the identification of those patients most at risk of developing high-grade anal dysplasia. Copyright © 2013 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

  2. Four year efficacy of prophylactic human papillomavirus quadrivalent vaccine against low grade cervical, vulvar, and vaginal intraepithelial neoplasia and anogenital warts: randomised controlled trial

    DEFF Research Database (Denmark)

    Dillner, Joakim; Kjaer, Susanne K; Wheeler, Cosette M

    2010-01-01

    To evaluate the prophylactic efficacy of the human papillomavirus (HPV) quadrivalent vaccine in preventing low grade cervical, vulvar, and vaginal intraepithelial neoplasias and anogenital warts (condyloma acuminata).......To evaluate the prophylactic efficacy of the human papillomavirus (HPV) quadrivalent vaccine in preventing low grade cervical, vulvar, and vaginal intraepithelial neoplasias and anogenital warts (condyloma acuminata)....

  3. Advanced colorectal neoplasia risk stratification by penalized logistic regression.

    Science.gov (United States)

    Lin, Yunzhi; Yu, Menggang; Wang, Sijian; Chappell, Richard; Imperiale, Thomas F

    2016-08-01

    Colorectal cancer is the second leading cause of death from cancer in the United States. To facilitate the efficiency of colorectal cancer screening, there is a need to stratify risk for colorectal cancer among the 90% of US residents who are considered "average risk." In this article, we investigate such risk stratification rules for advanced colorectal neoplasia (colorectal cancer and advanced, precancerous polyps). We use a recently completed large cohort study of subjects who underwent a first screening colonoscopy. Logistic regression models have been used in the literature to estimate the risk of advanced colorectal neoplasia based on quantifiable risk factors. However, logistic regression may be prone to overfitting and instability in variable selection. Since most of the risk factors in our study have several categories, it was tempting to collapse these categories into fewer risk groups. We propose a penalized logistic regression method that automatically and simultaneously selects variables, groups categories, and estimates their coefficients by penalizing the [Formula: see text]-norm of both the coefficients and their differences. Hence, it encourages sparsity in the categories, i.e. grouping of the categories, and sparsity in the variables, i.e. variable selection. We apply the penalized logistic regression method to our data. The important variables are selected, with close categories simultaneously grouped, by penalized regression models with and without the interactions terms. The models are validated with 10-fold cross-validation. The receiver operating characteristic curves of the penalized regression models dominate the receiver operating characteristic curve of naive logistic regressions, indicating a superior discriminative performance. © The Author(s) 2013.

  4. Taller de recursos manipulativos para el aprendizaje de la geometría en educación primaria

    OpenAIRE

    Climent Rodríguez, Nuria

    2010-01-01

    Esta actividad tiene una doble vertiente: por un lado, los alumnos en pequeños grupos indagan sobre un material manipulativo para el aprendizaje de contenidos geométricos en Ed. Primaria; por otra parte, preparan un taller para que sus compañeros de clase experimenten con dicho material y puedan acercarse a lo que ellos han reflexionado sobre el mismo.

  5. Specific immune cell and cytokine characteristics of human testicular germ cell neoplasia.

    Science.gov (United States)

    Klein, Britta; Haggeney, Thomas; Fietz, Daniela; Indumathy, Sivanjah; Loveland, Kate L; Hedger, Mark; Kliesch, Sabine; Weidner, Wolfgang; Bergmann, Martin; Schuppe, Hans-Christian

    2016-10-01

    Which immune cells and cytokine profiles are characteristic for testicular germ cell neoplasia and what consequences does this have for the understanding of the related testicular immunopathology? The unique immune environment of testicular germ cell neoplasia comprises B cells and dendritic cells as well as high transcript levels of IL-6 and other B cell supporting or T helper cell type 1 (Th1)-driven cytokines and thus differs profoundly from normal testis or inflammatory lesions associated with hypospermatogenesis. T cells are known to be the major component of inflammatory infiltrates associated with either hypospermatogenesis or testicular cancer. It has previously been reported that B cells are only involved within infiltrates of seminoma samples, but this has not been investigated further. Immunohistochemical characterisation (IHC) of infiltrating immune cells and RT-qPCR-based analysis of corresponding cytokine microenvironments was performed on different testicular pathologies. Testicular biopsies, obtained from men undergoing andrological work-up of infertility or taken during surgery for testicular cancer, were used in this study. Samples were grouped as follows: (i) normal spermatogenesis (n = 18), (ii) hypospermatogenesis associated with lymphocytic infiltrates (n = 10), (iii) samples showing neoplasia [germ cell neoplasia in situ (GCNIS, n = 26) and seminoma, n = 18]. IHC was performed using antibodies against T cells (CD3+), B cells (CD20cy+), dendritic cells (CD11c+), macrophages (CD68+) and mast cells (mast cell tryptase+). Degree and compartmental localisation of immune cells throughout all groups analysed was evaluated semi-quantitatively. RT-qPCR on RNA extracted from cryo-preserved tissue samples was performed to analyse mRNA cytokine expression, specifically levels of IL-1β, IL-6, IL-17a, tumour necrosis factor (TNF)-α (pro-inflammatory), IL-10, transforming growth factor (TGF)-β1 (anti-inflammatory), IL-2, IL-12a, IL-12b

  6. La oncología en la atención primaria de salud

    OpenAIRE

    Mendoza del Pino, Mario Valentín

    2009-01-01

    El Libro “La Oncología en la Atención Primaria de Salud”, constituye un importante aporte para la prevención y atención del cáncer, desde una valoración muy integral. Se trata de una enfermedad que constituye la segunda causa de muerte en nuestro país, que tanto dolor y sufrimiento representa para el paciente y sus familiares. El libro tiene un enfoque muy útil para el Equipo Básico de Salud, ya que enfatiza que el cáncer puede prevenirse si logramos en la población cambios en el estilo de v...

  7. Risk of head-and-neck cancer following a diagnosis of severe cervical intraepithelial neoplasia

    DEFF Research Database (Denmark)

    Svahn, Malene F; Munk, C; Jensen, S M

    2016-01-01

    OBJECTIVE: Women with a history of cervical intraepithelial neoplasia grade 3 including adenocarcinoma in situ (CIN3/AIS) may be more prone to develop cancers of the ano-genital region and head-and-neck cancers. The current literature is, however, limited. METHODS: We established a nationwide...

  8. Competencias desde la perspectiva intercultural para el ompetencias grado de educación primaria

    Directory of Open Access Journals (Sweden)

    Fernando GONZÁLEZ ALONSO

    2005-01-01

    matemáticos, el pensamiento científico, el trabajo en equipo, los cambios sociales, la producción creativa y estética, son algunas de las más importantes en las áreas de lengua, matemáticas, ciencias, geografía e historia y educación artística. La idea es capacitar al profesorado para que pueda ayuda a alcanzar a los alumnos los objetivos de cada una de las áreas de Educación Primaria desde la diversidad intercultural.

  9. HPV infection, anal intra-epithelial neoplasia (AIN and anal cancer: current issues

    Directory of Open Access Journals (Sweden)

    Stanley Margaret A

    2012-09-01

    Full Text Available Abstract Background Human papillomavirus (HPV is well known as the major etiological agent for ano-genital cancer. In contrast to cervical cancer, anal cancer is uncommon, but is increasing steadily in the community over the last few decades. However, it has undergone an exponential rise in the men who have sex with men (MSM and HIV + groups. HIV + MSM in particular, have anal cancer incidences about three times that of the highest worldwide reported cervical cancer incidences. Discussion There has therefore traditionally been a lack of data from studies focused on heterosexual men and non-HIV + women. There is also less evidence reporting on the putative precursor lesion to anal cancer (AIN – anal intraepithelial neoplasia, when compared to cervical cancer and CIN (cervical intraepithelial neoplasia. This review summarises the available biological and epidemiological evidence for HPV in the anal site and the pathogenesis of AIN and anal cancer amongst traditionally non-high risk groups. Summary There is strong evidence to conclude that high-grade AIN is a precursor to anal cancer, and some data on the progression of AIN to invasive cancer.

  10. Pretreatment Serum Cystatin C Levels Predict Renal Function, but Not Tumor Characteristics, in Patients with Prostate Neoplasia

    Directory of Open Access Journals (Sweden)

    Feilong Yang

    2017-01-01

    Full Text Available To evaluate the role of Cystatin C (Cys-C in tumorigenesis and progression of prostate cancer (PCa, we retrospectively collected the clinical information from the records of 492 benign prostatic hyperplasia (BPH, 48 prostatic intraepithelial neoplasia (PIN, and 173 PCa patients, whose disease was newly diagnosed and histologically confirmed. Pretreatment serum Cys-C levels were compared across the various groups and then analyzed to identify relationships, if any, with clinical and pathological characteristics of the PCa patient group. There were no significant differences in serum Cys-C levels among the three groups (P > 0.05. In PCa patients with normal SCr levels, patient age was correlated with serum Cys-C level (P ≤ 0.001 but did not correlate with alkaline phosphatase (AKP, lactate dehydrogenase (LDH, prostate specific antigen (PSA, Gleason score, or bone metastasis status (P > 0.05. Age and SCr contributed in part to the variations in serum Cys-C levels of PCa patients (r = 0.356, P ≤ 0.001; r = 0.520, P ≤ 0.001. In conclusion, serum Cys-C levels predict renal function in patients with prostate neoplasia, but were not a biomarker for the development of prostate neoplasia, and were not correlated with the clinicopathological characteristics of PCa.

  11. Profilaxis primaria para tromboembolismo venoso en pacientes ambulatorios con cáncer sometidos a quimioterapia

    Directory of Open Access Journals (Sweden)

    2013-07-01

    Conclusiones de los autores: La tromboprofilaxis primaria con HBPM redujo significativamente la incidencia del TEV sintomático en los pacientes ambulatorios con cáncer tratados con quimioterapia. Sin embargo, la ausencia de poder estadístico obstaculiza la posibilidad de establecer conclusiones definitivas sobre los efectos en cuanto a los resultados principales de seguridad, lo cual obliga a la realización de estudios adicionales para determinar el cociente riesgos/beneficios de la HBPM en este contexto.

  12. Memorias para armar: Las conmemoraciones del 24 de Marzo en escuelas primarias del conurbano bonaerense

    OpenAIRE

    Amézola, Gonzalo de; D'Achary, Claudia

    2009-01-01

    Este artículo se ocupa del problema del tratamiento del pasado reciente en la escuela. Describe las distintas representaciones de la última dictadura militar que se encuentran presentes en los discursos pronunciados en las conmemoraciones realizadas en 2008 para recordar el golpe de Estado del 24 de marzo de 1976 en escuelas primarias del partido de Malvinas Argentinas, ubicado en el Conurbano Bonaerense. Se analiza en esos discursos la presencia de distintas narraciones de la memoria colecti...

  13. Endometriose intestinal: uma doença benigna? Bowel endometriosis: a benign disease?

    Directory of Open Access Journals (Sweden)

    Marco Antonio Bassi

    2009-01-01

    Full Text Available A despeito do caráter benigno da endometriose, estima-se que 1% dos casos esteja relacionado com câncer, especialmente quando ambas as condições ocorrem nos ovários. Lesões extra-ovarianas encontradas no septo retovaginal, cólon, bexiga, vagina e peritônio da região pélvica também já foram associadas com neoplasias malignas. Várias características do tecido endometrial ectópico o aproximam do fenótipo neoplásico, e a própria endometriose possui comportamento tipicamente neoplásico com capacidade de invasão do estroma adjacente e associação com lesões à distância. Esta revisão atualiza conhecimentos diagnósticos, clínicos e terapêuticos dos implantes intestinais de tecido endometriótico, bem como sua relação com processos neoplásicos para melhor compreensão de seu caráter benigno ou de seu eventual potencial para malignidade.Endometriosis is generally assumed to be a benign disease, but it is estimated that 1% of cases are associated with cancer, especially when both conditions are present in the ovary. Extra-ovarian lesions in the rectovaginal septum, colon, bladder, vagina and peritoneum were already associated with malign neoplasia. Several characteristics of endometrial tissue are very similar to the neoplasia phenotype. Endometriosis itself typically behaves as a neoplasia process, spreading over adjacent stroma and being associated with distant lesions. This is an update on the diagnostic, clinical, and therapeutic knowledge of, management of bowel implants of endometrial tissue, as well as the relation with neoplastic processes to better understand its benign nature or eventual potential for malignancy.

  14. Maestría en atención primaria de salud: Experiencia en Cuba

    Directory of Open Access Journals (Sweden)

    Irene Perdomo Victoria

    2003-04-01

    Full Text Available La estrategia de la Atención Primaria de Salud es abarcadora, compleja e integradora. Promueve la reorganización de los servicios de atención a la salud de forma que la atención secundaria y terciaria, actúen como apoyo y derivación del nivel de atención primaria. Se orientan las acciones en relación con los distintos factores determinantes de la salud y la enfermedad, requiere de un enfoque necesariamente intersectorial; y conlleva la implicación de individuos y comunidades, no solo en la toma de decisiones, sino también para el desarrollo de una mayor responsabilidad individual sobre su salud, la incorporación y el buen uso de la tecnología apropiada con atención a la relación entre los costos y la efectividad.The primary health care strategy is comprehensive and complex. It promotes the re-organization of health care services so that the secondary and tertiary care act as a sort of support of and derivation from the primary health care, and give guidance on the actions to be taken with different determining factors for health and disease. The strategy requires an inter-sector approach and entails the involvement of both individuals and community not only in the decision-taking process but also in the development of a higher level of individual responsibility for one´s health, and also the introduction and use of adequate technologies, taking cost-effectiveness relation into account.

  15. Características clínicas y toxicidad del tratamiento de tuberculosis en pacientes con cáncer

    Directory of Open Access Journals (Sweden)

    Luis Cuéllar

    Full Text Available Objetivos. Evaluar las características clínico-epidemiológicas de la tuberculosis activa en pacientes portadores de neoplasia maligna y evaluar la influencia del tratamiento antituberculoso sobre el manejo de cáncer en el Instituto Nacional de Enfermedades Neoplásicas entre el 2008 y 2013. Materiales y métodos. Estudio observacional de casos de tuberculosis diagnosticados mediante baciloscopía positiva en pacientes con cáncer. Se revisó la información clínica, evolución, e información patológica de la neoplasia. Resultados. Se encontraron 76 casos de tuberculosis activa luego del diagnóstico de cáncer. La mediana de edad fue 51,3 años. La mediana de seguimiento fue 2,1 años. Las neoplasias más frecuentes fueron leucemia linfática aguda (14,5% para las hematológicas y cáncer de cérvix (14,5%, mama (10,5% y gástrico (7,9% para las no hematológicas. El 27,6% de los pacientes presentó recurrencia de la neoplasia; el diagnóstico de tuberculosis confundió el estadiaje inicial en 6,9% y se planteó inicialmente como recurrencia del cáncer en 11,1% (neoplasias de mama y colon. El diagnóstico de tuberculosis retrasó o influyó en la reducción de dosis del tratamiento antineoplásico en 11,1% de los casos (leucemia linfática aguda y linfoma no Hodgkin. El 8,3% de los pacientes presentó toxicidad al tratamiento antituberculoso. Conclusiones. Los pacientes con cáncer pueden presentar infección activa por tuberculosis. El efecto de interferencia del diagnóstico y tratamiento de tuberculosis sobre la evaluación del cáncer y el tratamiento antineoplásico en nuestra serie es mínimo.

  16. Educación para la salud renal en personas mayores desde un centro de atención primaria Renal health education older people from a center primary care

    OpenAIRE

    Pilar Peña Amaro; Juan García López; Yolanda Lupiáñez López; Encarna Figueroa Magaña; María Gámiz Magaña; Ana Trujillo Abad

    2011-01-01

    Realizamos un programa de educación para la salud enfocado a la prevención primaria y secundaria de la enfermedad renal en personas mayores desde un centro de atención primaria. Ponemos un póster en la sala de espera del centro con los contenidos sobre los que queremos incidir (hábitos de vida renosaludables). Cuando el paciente acude a consulta evaluamos los conocimientos que tenía y los que ha adquirido y los comentamos por si hay preguntas o dudas. Las personas mayores asocian la ingesta d...

  17. RELACIÓN ENTRE EL NIVEL DE CONOCIMIENTO SOBRE PREVENCIÓN PRIMARIA Y LA CONDICIÓN DE SALUD BUCAL EN GESTANTES DEL HOSPITAL REGIONAL HIPÓLITO UNANUE. TACNA. 2013

    OpenAIRE

    BEGAZO DE LA CRUZ, MIGUEL ARTURO

    2014-01-01

    PREVENCIÓN PRIMARIA CONCEPTO NIVELES DE PREVENCIÓN PRIMARIA ÍNDICE DE HIGIENE ORAL SIMPLIFICADO ÍNDICE DE CARIES DENTAL: CPO PROCEDIMIENTO PARA EL EXAMEN CÓDIGOS Y CRITERIOS PARA SU VALORACIÓN CÁLCULO DEL ÍNDICE LIMITACIONES DEL ÍNDICE ÍNDICE PERIODONTAL DE RUSSELL CONCEPTO ENFERMEDAD PERIODONTAL CRITERIOS PARA LA APLICACIÓN DEL ÍNDICE RESEÑA HISTÓRICA DEL IPR CÓDIGOS Y CRITERIOS PARA LA EVALUACIÓN INSTRUMENTAL Y MATERIAL PARA EL EXAMEN PROCEDIMIENTO PARA EL EXAMEN REGISTRO DE CÓDIGOS EN LA F...

  18. Análisis de la estructura primaria y secundaria del ARN de transferencia mitocondrial para serina en siete especies de Lutzomyia

    Directory of Open Access Journals (Sweden)

    Rafael José Vivero

    2007-09-01

    Conclusión. Los cambios en la secuencia primaria de nucleótidos y los rearreglos en la estructura secundaria del ARNtSer son potencialmente útiles para la discriminación taxonómica de las especies flebotomíneas estudiadas.

  19. Câncer de colo do útero: mortalidade em santa catarina - Brasil, 2000 a 2009

    Directory of Open Access Journals (Sweden)

    Maria Angélica Arzuaga-Salazar

    2011-01-01

    Full Text Available El cáncer de cuello uterino en Brasil es la tercera neoplasia más común en mujeres y presenta alta mortalidad. El objetivo del estudio fue evaluar la mortalidad por causa del cáncer de cuello uterino en el Estado de Santa Catarina, en el periodo de 2000 a 2009. Es un estudio descriptivo, con la inclusión de todas las muertes de mujeres por causa del cáncer de cuello uterino. En los datos recogidos en el Sistema de Información sobre Mortalidad del Ministerio de Salud de Brasil, identificó 1253 muertes de mujeres relacionadas con esta neoplasia. La tasa de mortalidad calculada en el período varió 3,6 a 4,9 muertes por 100.000 mujeres, siendo mayor en las mujeres con más de sesenta años. La enfermería contribuye a construir una cultura de prevención de esta neoplasia, para realización de las pruebas de diagnóstico y para la captura y seguimiento de las mujeres en riesgo por la red atención primaria de salud.

  20. DEGRO practical guidelines: radiotherapy of breast cancer II. Radiotherapy of non-invasive neoplasia of the breast

    International Nuclear Information System (INIS)

    Souchon, R.; Sautter-Bihl, M.L.; Sedlmayer, F.; Budach, W.; Dunst, J.; Feyer, P.; Fietkau, R.; Sauer, R.; Harms, W.; Wenz, F.; Haase, W.

    2014-01-01

    To complement and update the 2007 practice guidelines of the breast cancer expert panel of the German Society of Radiation Oncology (DEGRO) for radiotherapy (RT) of breast cancer. Owing to its growing clinical relevance, in the current version, a separate paper is dedicated to non-invasive proliferating epithelial neoplasia of the breast. In addition to the more general statements of the German interdisciplinary S3 guidelines, this paper is especially focused on indication and technique of RT in addition to breast conserving surgery. The DEGRO expert panel performed a comprehensive survey of the literature comprising recently published data from clinical controlled trials, systematic reviews as well as meta-analyses, referring to the criteria of evidence-based medicine yielding new aspects compared to 2005 and 2007. The literature search encompassed the period 2008 to September 2012 using databases of PubMed and Guidelines International Network (G-I-N). Search terms were ''non invasive breast cancer'', ''ductal carcinoma in situ, ''dcis'', ''borderline breast lesions'', ''lobular neoplasia'', ''radiotherapy'' and ''radiation therapy''. In addition to the more general statements of the German interdisciplinary S3 guidelines, this paper is especially focused on indications of RT and decision making of non-invasive neoplasia of the breast after surgery, especially ductal carcinoma in situ. Among different non-invasive neoplasia of the breast only the subgroup of pure ductal carcinoma in situ (DCIS; synonym ductal intraepithelial neoplasia, DIN) is considered for further recurrence risk reduction treatment modalities after complete excision of DCIS, particularly RT following breast conserving surgery (BCS), in order to avoid a mastectomy. About half of recurrences are invasive cancers. Up to 50?% of all recurrences require salvage mastectomy. Randomized clinical trials and a huge number of mostly observational studies have unanimously demonstrated that RT significantly

  1. La transición primaria – secundaria en los Institutos – Escuela en Catalunya

    Directory of Open Access Journals (Sweden)

    Màrius Martínez Muñoz

    2015-01-01

    Full Text Available Se presentan los resultados de un estudio sobre los aspectos de orientación de los 17 Institutos – Escuela (I‐E, centros públicos que acogen en una misma institución, educación infantil, primaria y secundaria puestos en marcha en Catalunya a partir de la Ley de Educación de Catalunya (LEC, 2009 recuperando la innovación impulsada en la República. El estudio revisó los aspectos de orientación y transición entre etapas de dichos centros y contrastó dicho funcionamiento con el que tenían centros de primaria y secundaria, de características similares en el mismo territorio. Se utilizaron cuestionarios electrónicos respondidos por responsables de la orientación de las tres tipologías de centro (primara, secundaria, I–E, integrantes de sus ampas, tutores y miembros de sus equipos directivos. Se identificaron visiones distintas de las prácticas de orientación en función del tipo de centro, de la persona encuestada y de su rol. El estudio permitió identificar también 50 prácticas de referencia realizadas tanto en los I‐E como en la perspectiva territorial en centros ordinarios. Los I‐E suponen, a la luz del estudio, una alternativa eficaz, no sólo para la mejor articulación entre etapas sino también para luchar contra las desigualdades y las situaciones de vulnerabilidad.

  2. El acoso escolar en Educación Primaria en la provincia de Huelva

    OpenAIRE

    Ávila Fernández, José Antonio

    2013-01-01

    El resumen que a continuación se presenta, es el reflejo del trabajo de tesis doctoral realizado bajo el título «El Acoso Escolar en Educación Primaria en la Provincia de Huelva». En los últimos años ha existido una preocupación social en relación al tema de la violencia escolar, reconociéndose como un problema común. Los medios de comunicación se han ocupado de difundir situaciones límites relacionadas con e! comportamiento de escolares; a nivel internacional se ha afrontado la investigac...

  3. Educación Emocional Trilingüe en la enseñanza primaria

    OpenAIRE

    Calavia-de-Orbe, Nuria

    2012-01-01

    Lo que a continuación se presenta es un Trabajo de Final de Grado de Maestro. Se ha decidido hacer una propuesta de intervención porque tiene más posibilidad de aplicación inmediata que una investigación. El objeto del programa es el desarrollo de la inteligencia emocional mediante tres lenguas. La inteligencia emocional es la base de la educación integral por la que se aboga en la docencia actual. La finalidad es enseñar al alumnado de primaria a conocerse a uno/a mismo/a, y aprender a tr...

  4. Desigualdades en las escuelas primarias de la ciudad de Rosario: presencia de inmigrantes

    OpenAIRE

    Segura, María Laura; Pozzo, María Isabel

    2015-01-01

    El presente trabajo forma parte de mi Tesis de Licenciatura en Ciencias de la Educación por la U.N.R. titulada “Inclusión cultural de niños migrantes y descendientes en escuelas primarias de la ciudad de Rosario”, dirigida por la Dra. María Isabel Pozzo. La investigación fue llevada a cabo durante el período de los años 2009- 2012. Al iniciar la investigación, surgieron los siguientes interrogantes: ¿cómo resulta la inserción de los alumnos migrantes en las instituciones educativas?; ¿existen...

  5. A Multiscale Model Evaluates Screening for Neoplasia in Barrett's Esophagus.

    Directory of Open Access Journals (Sweden)

    Kit Curtius

    2015-05-01

    Full Text Available Barrett's esophagus (BE patients are routinely screened for high grade dysplasia (HGD and esophageal adenocarcinoma (EAC through endoscopic screening, during which multiple esophageal tissue samples are removed for histological analysis. We propose a computational method called the multistage clonal expansion for EAC (MSCE-EAC screening model that is used for screening BE patients in silico to evaluate the effects of biopsy sampling, diagnostic sensitivity, and treatment on disease burden. Our framework seamlessly integrates relevant cell-level processes during EAC development with a spatial screening process to provide a clinically relevant model for detecting dysplastic and malignant clones within the crypt-structured BE tissue. With this computational approach, we retain spatio-temporal information about small, unobserved tissue lesions in BE that may remain undetected during biopsy-based screening but could be detected with high-resolution imaging. This allows evaluation of the efficacy and sensitivity of current screening protocols to detect neoplasia (dysplasia and early preclinical EAC in the esophageal lining. We demonstrate the clinical utility of this model by predicting three important clinical outcomes: (1 the probability that small cancers are missed during biopsy-based screening, (2 the potential gains in neoplasia detection probabilities if screening occurred via high-resolution tomographic imaging, and (3 the efficacy of ablative treatments that result in the curative depletion of metaplastic and neoplastic cell populations in BE in terms of the long-term impact on reducing EAC incidence.

  6. GUÍA PARA EL DIAGNÓSTICO DE LAS INMUNODEFICIENCIAS PRIMARIAS EN EL LABORATORIO CLÍNICO

    Directory of Open Access Journals (Sweden)

    A. Fonseca-Gutiérrez

    2006-12-01

    Full Text Available Las inmunodeficiencias primarias son un grupo heterogéneo de desórdenes hereditarios que afectan los mecanismos de la inmunidad inespecífica y específica del huésped. En la mayoría de los casos se manifiestan en los primeros cinco años de vida, pero pueden presentarse a cualquier edad, encontrándose un gran predominio masculino (Oleastro, 2001. Han sido clasificadas, de acuerdo al defecto molecular que presentan, en inmunodeficiencias ligadas al cromosoma X e inmunodeficiencias autosómicas recesivas (Jones, 2000. Su prevalencia se ha establecido en 1 por cada 10.000 nacidos vivos, aumentando considerablemente desde el primer caso reportado en 1969 (Lim, 2004. Este incremento puede estar favorecido por la existencia de pruebas especializadas de laboratorio que permiten hacer una detección temprana de anormalidades inmunológicas. La valoración de la inmunocompetencia en un individuo con sospecha de inmunodeficiencia primaria requiere de un análisis cuantitativo, cualitativo o estructural y de estudios funcionales que permiten detectar la integridad de sus mecanismos de defensa. De acuerdo con el componente inmune que se quiere evaluar existen diferentes estudios que se pueden realizar de acuerdo a su grado de complejidad en pruebas de primera, segunda y tercera etapa, las cuales serán revisadas en este artículo. (Montoya, 2004, Ortega, 2005.

  7. Elementos de análisis de la educación para la alimentación saludable en la escuela primaria

    Directory of Open Access Journals (Sweden)

    Juan Manuel Muñoz Cano

    2013-01-01

    Full Text Available El objetivo de la investigación fue caracterizar los elementos de estudio de la educación para la alimentación saludable en la escuela primaria. Esto fue para establecer líneas de investigaciones del contexto escolar y desarrollar mejores prácticas educativas integradoras que involucren a educandos, docentes y la comunidad. El estudio de caso fue realizado mediante una observación participante a través de un taller con ejes en educación para la alimentación y la sustentabilidad realizado a lo largo de un semestre en una escuela rural multigrado. Se identificaron elementos que deben considerarse en la educación para la alimentación saludable en la escuela primaria: la vinculación entre la preparación de los desayunos escolares y los procesos educativos, las orientaciones transversales con educación ambiental y sustentabilidad, así como la urgente reconfiguración de los contenidos conceptuales, procedimentales y valorales.

  8. Stepwise radical endoscopic resection for Barrett's esophagus with early neoplasia: report on a Brussels' cohort

    NARCIS (Netherlands)

    Pouw, R. E.; Peters, F. P.; Sempoux, C.; Piessevaux, H.; Deprez, P. H.

    2008-01-01

    Background and study aims: The aim of this retrospective study was to assess safety and efficacy of stepwise radical endoscopic resection (SRER) in patients with Barrett's esophagus with high-grade intraepithelial neoplasia (HGIN) or early cancer. Patients and methods: Patients undergoing SRER

  9. Tuberculosis primaria de la glándula suprarrenal: comunicación de dos casos

    OpenAIRE

    Coras, Natalia; Somocurcio, José; Aguilar, Cristian

    2013-01-01

    En muchas áreas del mundo, la tuberculosis tiene gran prevalencia y sigue siendo la principal causa de insuficiencia suprarrenal. Clínicamente, esta enfermedad permanece sin sintomatología durante sus primeros estadios, debido a que la pérdida de la función adrenal suele ser progresiva; los síntomas tienen aparición gradual e insidiosa, en su mayoría inespecíficos. Presentamos el caso de dos mujeres con cuadro clínico de insuficiencia adrenal primaria crónica, con afección bilateral de ambas ...

  10. Capital social y políticas de Atención Primaria de la Salud

    OpenAIRE

    Ernesto Pablo BÁSCOLO; Natalia YAVICH

    2016-01-01

    El objetivo de este trabajo es analizar la influencia de la configuración del capital social de las políticas de atención primaria de la salud (APS) sobre las condiciones de acceso a los servicios de salud. Se llevó a cabo un estudio de casos múltiples (Cochabamba-Bolivia, Rosario y Vicente López-Argentina) retrospectivo (1990-2008). El concepto de capital social fue entendido como el resultado de la relación entre Estado y sociedad. En Rosario se lograron mejoras sustantivas en las condi...

  11. RISK FACTORS FOR GESTATIONAL TROPHOBLASTIC NEOPLASIA: A CASE CONTROL STUDY IN A TERTIARY HOSPITAL

    Directory of Open Access Journals (Sweden)

    Hema Sreedharan Nair

    2016-10-01

    Full Text Available BACKGROUND Gestational trophoblastic disease is a spectrum of proliferative abnormalities of the trophoblast. GTD represents a benign form of the disease while GTN is the malignant often metastatic lesion. 75-80 per cent of patients initially diagnosed as GTD will follow a benign course after dilatation and curettage. 15-20 per cent develop locally invasive disease and 3-5 per cent develop metastatic lesions. The study aims to assess the proportion of gestational trophoblastic neoplasia among women with gestational trophoblastic disease and identify the risk factors for chemotherapy in gestational trophoblastic neoplasia. MATERIALS AND METHODS This is a case-control study conducted in a tertiary hospital during a 5-year period. Cases are gestational trophoblastic neoplasia diagnosed by either rising beta-HCG levels or plateauing beta-HCG levels or by histological evidence of choriocarcinoma. Controls are cases of gestational trophoblastic disease post evacuation with normal HCG regression at 8 weeks. There were 306 controls and 57 cases. RESULTS Tabulated and analysed using SPSS package. Of the 363 patients of gestational trophoblastic disease, 57 (15.7% needed chemotherapy. 98.2% belonged to the age group of 20-35 years. 63% had gestational age of more than 12 weeks, 56.1% had pre-evacuation HCG of more than 40,000. 15.7% needed combination therapy. CONCLUSION 1. 83.1% of patients belonged to age group of 20-30 years. 2. Blood group distribution of patients with gestational trophoblastic disease did not show any significance. 3. 15.7% of total patients were diagnosed to have gestational trophoblastic neoplasia that necessitated chemotherapy. 4. When uterine size was more than 12 weeks, a statistically significant number of patients needed chemotherapy compared to non-chemotherapy group. 5. When BHCG values were more than 40,000, a statistically significant number of patients needed chemotherapy. 6. A risk score of seven or more was found to

  12. Eficacia de terapia de presión negativa portátil en el abordaje de lesiones de pie diabético en Atención Primaria

    OpenAIRE

    Fernández Monasterio, Almudena

    2015-01-01

    Objetivos: Evaluar la eficacia de la terapia de presión negativa portátil en lesiones de pie diabético en Atención Primaria. Determinar la influencia en el tiempo de cicatrización y calidad de vida. Metodología: Diseño experimental, ensayo clínico aleatorizado, abierto, con diseño en paralelo. Se llevará a cabo en Servicio de Atención Primaria de las Áreas de Cervo y Lugo (Galicia, España). La selección de la muestra, se realizará en los Servicios de AP, Endocrinología, Cirugía General, Cirug...

  13. DISPERSIÓN PRIMARIA DIURNA DE SEMILLAS DE DACRYODES CHIMANTENSIS Y PROTIUM PANICULATUM (BURSERACEAE EN UN BOSQUE DE TIERRA FIRME DE LA AMAZONIA COLOMBIANA

    Directory of Open Access Journals (Sweden)

    ROZO-MORA MARÍA CAROLINA

    2004-06-01

    Full Text Available Estudiamos la dispersión primaria diurna de las semillas de Dacryodes chimantensisy Protium paniculatum (Burseraceae en un bosque de tierra firme de la Amazoniacolombiana. Desde diciembre de 1999 hasta junio de 2000 registramos las visitas defrugívoros, la remoción de frutos y la dispersión primaria de semillas de cincoindividuos por especie. Encontramos que D. chimantensis presenta en promediouna mayor altura, DAP, área de proyección de la copa y mayores cosechas que P.paniculatum. El porcentaje del valor promedio de frutos maduros de D. chimantensisosciló entre el 3 y el 21% del tamaño de la cosecha durante toda la estación de frutos,mientras que este porcentaje en P. paniculatum varió entre el 1 y 15%. Observamosactividad frugívora diurna en cuatro de los cinco individuos de D. chimantensisestudiados, mientras que en los individuos de P. paniculatum no se presentófrugivoría diurna. Únicamente Amazona festiva y A. amazonica consumieron frutosde D. chimantensis y removieron en promedio 1.8 % de los frutos por árbol, pero noalejaron semillas viables del parental (dispersión primaria. En las trampas ubicadasbajo el área de la proyección de la copa sobre el suelo, encontramos que el númerode frutos probados, intactos y dañados por frugívoros fue similar para las dosespecies. Las cosechas pequeñas, el número reducido de frutos maduros y las bajastasas de reducción de la cosecha, sumado a las pocas visitas diurnas, la baja remocióny dispersión primaria diurna de semillas por parte de los frugívoros, sugieren queestas dos especies tuvieron una dispersión limitada. Discutimos si la dispersión poranimales puede estar modelando la abundancia y los patrones de distribución espacialde estas especies.

  14. Memorias para armar. Las conmemoraciones del 24 de Marzo en escuelas primarias del conurbano bonaerense

    OpenAIRE

    Gonzalo de Amézola; Claudia D\\u2019Achary

    2009-01-01

    Este artículo se ocupa del problema del tratamiento del pasado reciente en la escuela. Describe las distintas representaciones de la última dictadura militar que se encuentran presentes en los discursos pronunciados en las conmemoraciones realizadas en 2008 para recor - dar el golpe de Estado del 24 de marzo de 1976 en escuelas primarias del partido de Malvinas Argentinas, ubicado en el Conurbano Bonae - rense. Se analiza en esos discursos la presencia de distintas narracio - nes de la memori...

  15. Hipertermia maligna no Brasil: análise da atividade do hotline em 2009 Hipertermia maligna en Brasil: análisis de la actividad del hotline en 2009 Malignant hyperthermia in Brazil: analysis of hotline activity in 2009

    Directory of Open Access Journals (Sweden)

    Helga Cristina Almeida da Silva

    2013-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Hipertermia maligna (HM é doença farmacogenética, com reação hipermetabólica anormal a anestésicos halogenados e/ou relaxantes musculares despolarizantes. Desde 1991 há um serviço hotline de atendimento telefônico para HM no Brasil, disponível 24 horas por dia, em São Paulo. Este artigo analisa a atividade do serviço brasileiro de hotline para HM em 2009. MÉTODOS: Análise prospectiva de todas chamadas telefônicas paria maligna (HM é doença farmacogenética, com reação hipermetabólica anormal a anestésicos halogenados e/ou relaxantes musculares despolarizantes. Desde 1991 há um serviço hotline de atendimento telefônico para HM no Brasil, disponível 24 horas por dia, em São Paulo. Este art go analisa a at vidade do serviço brasileiro de hotline para HM em 2009a o serviço brasileiro de hotline para HM, de janeiro a dezembro de 2009. RESULTADOS: Foram recebidas 22 ligações; 21 provenientes do Sul-Sudeste do Brasil e uma do Norte. Quinze eram pedidos de informações gerais sobre HM. Sete foram suspeitas de crises agudas de HM, das quais duas não foram consideradas como HM. Nas cinco crises compatíveis com HM, todos os pacientes receberam anestésicos inalatórios halogenados (2 isoflurano, 3 sevoflurano e um usou também succinilcolina; havia quatro homens e uma mulher, com média de idade de 18 anos (2-27. Problemas descritos nas cinco crises de HM: taquicardia (cinco, aumento do gás carbônico expirado (quatro, hipertermia (três, acidemia (um, rabdomiólise (um e mioglobinúria (um. Um paciente recebeu dantrolene. Todos os cinco pacientes com crises de HM foram seguidos em unidade de terapia intensiva e recuperaram-se sem sequelas. A suscetibilidade à HM foi posteriormente confirmada em dois pacientes por meio do teste de contratura muscular in vitro. CONCLUSÕES: O número de chamadas por ano no serviço brasileiro de hotline para HM ainda é reduzido. As características das crises

  16. Tumor ocular metastásico Metastatic ocular tumor

    Directory of Open Access Journals (Sweden)

    Martha G Domínguez Expósito

    2004-06-01

    Full Text Available El carcinoma metastásico del ojo es considerado la neoplasia maligna que más frecuente se encuentra de forma intraocular. Solo cerca del 10 % de las personas que tienen una o más lesiones metastásicas intraoculares son detectadas clínicamente antes de la muerte. A menudo, el carcinoma metastásico ocular es diagnosticado por el oftalmólogo ante la presencia de síntomas oculares. Las lesiones están localizadas con preferencia en coroides. Nos motivo a realizar la presentación de este caso la presencia de lesiones intraoculares múltiples tumorales metastásicos en un paciente cuyo síntoma de presentación fue la disminución de la agudeza visualThe eye metastatic carcinoma is considered the most frequently found intraocular malignant neoplasia. Only 10 % of the persons with one or more metastatic intraocular injuries are clinically detected before death. The metastatic ocular carcinoma is often diagnosed by the ophthalmologist in the presence of ocular symptoms. The injuries are preferably located in the choroid. The appearance of multiple metastatic intraaocular tumoral injuries in a patient whose chief complaint was the reduction of visual acuity motivated us to presente this case

  17. Braquiterapia de alta taxa de dose no Brasil High-dose rate brachytherapy in Brazil

    Directory of Open Access Journals (Sweden)

    Sérgio Carlos Barros Esteves

    2004-10-01

    Full Text Available A braquiterapia de alta taxa de dose foi introduzida em nosso meio em janeiro de 1991. Desde então, houve uma mudança significativa na abordagem das neoplasias malignas em relação às vantagens do novo método, e também resolução da demanda reprimida de braquiterapia para as neoplasias ginecológicas. Nos primeiros dez anos de atividade, o Brasil tratou, em 31 serviços, 26.436 pacientes com braquiterapia, sendo mais de 50% das pacientes portadoras de neoplasias do colo uterino. Este estudo mostra o número e o perfil de pacientes tratados com esse método e a sua distribuição no território nacional, deixando explícito o benefício da braquiterapia de alta taxa de dose para o Brasil.High-dose rate brachytherapy was first introduced in Brazil in January 1991. Significant changes in the management of malignant neoplasms were observed since utilization of high-dose rate brachytherapy. The high number of gynecological patients awaiting for brachytherapy also decreased during this period. In the first ten years 26,436 patients were treated with high-dose rate brachytherapy. More than 50% of these patients presented neoplasms of the uterine cervix. In this study we present the number and profile of the patients treated with high-dose rate brachytherapy as well as the distribution of these patients in the Brazilian territory, proving the benefit of the use of high-dose rate brachytherapy in Brazil.

  18. Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells

    OpenAIRE

    Lee, Jonghyeob; Snyder, Emily R.; Liu, Yinghua; Gu, Xueying; Wang, Jing; Flowers, Brittany M.; Kim, Yoo Jung; Park, Sangbin; Szot, Gregory L.; Hruban, Ralph H.; Longacre, Teri A.; Kim, Seung K.

    2017-01-01

    Development of systems that reconstitute hallmark features of human pancreatic intraepithelial neoplasia (PanINs), the precursor to pancreatic ductal adenocarcinoma, could generate new strategies for early diagnosis and intervention. However, human cell-based PanIN models with defined mutations are unavailable. Here, we report that genetic modification of primary human pancreatic cells leads to development of lesions resembling native human PanINs. Primary human pancreas duct cells harbouring...

  19. El clima organizacional y el desempeño docente en el nivel primaria de la Institución Educativa N° 3063 “Patricia Natividad Sánchez” Independencia – 2015

    OpenAIRE

    Ramos Amaro, Luis Antonio

    2016-01-01

    En el presente trabajo de investigación titulado: El Clima Organizacional y el Desempeño Docente en el nivel primaria de la Institución Educativa N° 3063 “Patricia Natividad Sánchez” Independencia – 2015, donde se planteó como problema de investigación: ¿Qué relación existe entre el Clima Organizacional y el desempeño docente en el nivel primaria de la Institución Educativa N° 3063 “Patricia Natividad Sánchez”, Independencia – 2015?. Teniendo como objetivo general: Determinar l...

  20. Factores de riesgo en diabetes mellitus y pie diabético: un enfoque hacia la prevención primaria

    Directory of Open Access Journals (Sweden)

    Análida E Pinilla

    2013-08-01

    Full Text Available Objetivo: revisar la literatura sobre factores de riesgo asociados a diabetes mellitus y sus complicaciones, las estrategias de prevención y la importancia de programas interdisciplinarios para mejorar la calidad de vida. Fuente de datos: búsqueda de la literatura científica publicada en español e inglés, en bases de datos como Medline, SciELO y otras de la Universidad Nacional de Colombia mediante palabras clave; además, revisión de libros y consensos afines con el tema. Selección de estudios: se revisaron los títulos y resúmenes de documentos para seleccionar las publicaciones originales, así como las más representativas con relación a prevención primaria y educación. Extracción de datos: la literatura se clasificó y organizó de acuerdo con el tema principal y la estructura del artículo. Síntesis de datos: se inició un análisis crítico para ordenar y sintetizar los avances relacionados con los siguientes ítems: factores de riesgo para diabetes mellitus, epidemiología, pie diabético, educación, prevención primaria y estilos de vida relacionados con ejercicio y alimentación. Conclusión: el impacto de la diabetes mellitus y sus complicaciones en la salud de los individuos hace necesario establecer políticas de salud pública de prevención primaria, para minimizar el progreso de esta epidemia. Es esencial instaurar y fortalecer programas educativos orientados por profesionales de la salud, además de implementar la formación en diabetes mellitus en los currículos de pregrado y posgrado del área de la salud.

  1. Neoplasia in Three Aye-Ayes (Daubentonia madagascariensis).

    Science.gov (United States)

    Rodriguez Barbon, A; Cowen, R; Knott, C; Hughes, K; Allinson, K; Williams, C V; Routh, A

    2018-02-01

    Tumours diagnosed in three aged captive aye-ayes (Daubentonia madagascariensis), held in two different institutions, are described. A cerebral glioblastoma was diagnosed based on histological and immunohistochemical findings in one of the animals following initial presentation with bilateral mydriasis, absent pupillary reflex, head tilt and ataxia. A second animal was humanely destroyed due to impaired locomotion associated with spondylosis and a post-mortem diagnosis of cholangiocarcinoma was made based on histology with further confirmation with immunohistochemical labelling for cytokeratin 7. A third aye-aye suffering from dental disease was diagnosed with an oral squamous cell carcinoma following an excisional biopsy from a non-healing wound in the lip. Due to progression of the neoplasia the animal was humanely destroyed and post-mortem examination revealed the presence on an additional unilateral phaeochromocytoma. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Adult Immunohistochemical Markers Fail to Detect Intratubular Germ Cell Neoplasia in Prepubertal Boys with Cryptorchidism

    DEFF Research Database (Denmark)

    Kvist, Kolja; Clasen-Linde, Erik; Cortes, Dina

    2013-01-01

    Intratubular germ cell neoplasia (ITGCN) is a precursor to testicular germ cell cancer. It is characterized by large germ cells with large nuclei with a hyperchromatic, coarse chromatin pattern, large prominent nucleoli and abundant pale cytoplasm. In prepubertal boys these cells are located both...

  3. No Association of Blood Type O With Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1

    NARCIS (Netherlands)

    Nell, Sjoerd; van Leeuwaarde, Rachel S.; Pieterman, Carolina R. C.; de Laat, Joanne M.; Hermus, Ad R.; Dekkers, Olaf M.; de Herder, Wouter W.; van der Horst-Schrivers, Anouk N.; Drent, Madeleine L.; Bisschop, Peter H.; Havekes, Bas; Borel Rinkes, Inne H. M.; Vriens, Menno R.; Valk, Gerlof D.

    2015-01-01

    An association between ABO blood type and the development of cancer, in particular, pancreatic cancer, has been reported in the literature. An association between blood type O and neuroendocrine tumors in multiple endocrine neoplasia type 1 (MEN1) patients was recently suggested. Therefore, blood

  4. No Association of Blood Type O With Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1

    NARCIS (Netherlands)

    Nell, S.; Leeuwaarde, R.S. van; Pieterman, C.R.; Laat, J.M. de; Hermus, A.R.M.M.; Dekkers, O.M.; Herder, W.W. de; Horst-Schrivers, A.N. van der; Drent, M.L.; Bisschop, P.H.; Havekes, B.; Rinkes, I.H.; Vriens, M.R.; Valk, G.D.

    2015-01-01

    CONTEXT: An association between ABO blood type and the development of cancer, in particular, pancreatic cancer, has been reported in the literature. An association between blood type O and neuroendocrine tumors in multiple endocrine neoplasia type 1 (MEN1) patients was recently suggested. Therefore,

  5. No Association of Blood Type O With Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1

    NARCIS (Netherlands)

    Nell, Sjoerd; Van Leeuwaarde, Rachel S.; Pieterman, Carolina R. C.; de Laat, Joanne M.; Hermus, Ad R.; Dekkers, Olaf M.; de Herder, Wouter W.; van der Horst-Schrivers, Anouk N.; Drent, Madeleine L.; Bisschop, Peter H.; Havekes, Bas; Rinkes, Inne H. M. Borel; Vriens, Menno R.; Valk, Gerlof D.

    2015-01-01

    Context: An association between ABO blood type and the development of cancer, in particular, pancreatic cancer, has been reported in the literature. An association between blood type O and neuroendocrine tumors in multiple endocrine neoplasia type 1 (MEN1) patients was recently suggested. Therefore,

  6. Entorno psicosocial y estrés en trabajadores sanitarios de la sanidad pública: diferencias entre atención primaria y hospitalaria

    Directory of Open Access Journals (Sweden)

    Antonio García-Rodríguez

    2015-06-01

    Conclusiones: Nuestros hallazgos muestran que el ambiente psicosocial de los trabajadores sanitarios difiere del de la población asalariada española, siendo más desfavorable en el colectivo de facultativos/as de atención primaria.

  7. ¿ES EL MÉDICO FAMILIAR EL ESPECIALISTA CON MEJOR PERFIL PARA LA ATENCIÓN PRIMARIA EN SALUD Y EL MÁS IDÓNEO PARA LIDERAR SUS EQUIPOS DE ATENCIÓN?

    Directory of Open Access Journals (Sweden)

    Dairo F. Beltrán

    2012-04-01

    Full Text Available La Atención Primaria en Salud es el componente esencial del Sistema Sanitario. Sus actividades son la educación sanitaria, provisión de alimentos, nutrición adecuada, salubridad del agua, saneamiento básico, cuidado materno infantil, inmunización, prevención y control de enfermedades endémicas, tratamiento básico y abastecimiento de fármacos. La especialidad en Medicina Familiar se encarga del cuidado de la salud total del individuo y su familia, combinando ciencias del comportamiento con ciencias tradicionales clínicas y biológicas, ofreciendo un cuidado integral, humanizado y continuo sin importar edad, sexo ni órgano comprometido. Tanto la Medicina familiar como la Atención primaria en salud poseen elementos conceptuales que las definen individualmente y que además tienen en común: Primer contacto, Accesibilidad, Integralidad, Continuidad, Coordinación, Orientación familiar, Énfasis en promoción y prevención, Atención apropiada y Recursos adecuados y sostenibles. Teniendo en cuenta estos conceptos y la indiscutible congruencia entre la Medicina Familiar y la Atención Primaria en Salud, podemos afirmar que es ésta especialidad, la efectora más idónea para realizar las intervenciones médicas necesarias en el contexto de la Atención Primaria en Salud.

  8. Germline CDKN1B/p27Kip1 mutation in multiple endocrine neoplasia

    NARCIS (Netherlands)

    Georgitsi, Marianthi; Raitila, Anniina; Karhu, Auli; van der Luijt, Rob B.; Aalfs, Cora M.; Sane, Timo; Vierimaa, Outi; Mäkinen, Markus J.; Tuppurainen, Karoliina; Paschke, Ralph; Gimm, Oliver; Koch, Christian A.; Gündogdu, Sadi; Lucassen, Anneke; Tischkowitz, Marc; Izatt, Louise; Aylwin, Simon; Bano, Gul; Hodgson, Shirley; de Menis, Ernesto; Launonen, Virpi; Vahteristo, Pia; Aaltonen, Lauri A.

    2007-01-01

    Germline mutations in the MEN1 gene predispose to multiple endocrine neoplasia type 1 (MEN1) syndrome, but in up to 20-25% of clinical MEN1 cases, no MEN1 mutations can be found. Recently, a germline mutation in the CDKN1B gene, encoding p27(Kip1), was reported in one suspected MEN1 family with two

  9. Anal Cytology and Human Papillomavirus Genotyping in Women With a History of Lower Genital Tract Neoplasia Compared With Low-Risk Women.

    Science.gov (United States)

    Robison, Katina; Cronin, Beth; Bregar, Amy; Luis, Christine; DiSilvestro, Paul; Schechter, Steven; Pisharodi, Latha; Raker, Christina; Clark, Melissa

    2015-12-01

    To compare the prevalence of abnormal anal cytology and high-risk human papillomavirus (HPV) among women with a history of HPV-related genital neoplasia with women without a history of HPV-related genital neoplasia. A cross-sectional cohort study was performed from December 2012 to February 2014. Women were recruited from outpatient clinics at an academic medical center. Women with a history of high-grade cervical, vulvar, or vaginal cytology, dysplasia, or cancer were considered the high-risk group. Women with no history of high-grade anogenital dysplasia or cancer were considered the low-risk group. Human immunodeficiency virus-positive women were excluded. Anal cytology and HPV genotyping were performed. Women with abnormal anal cytology were referred for high-resolution anoscopy. There were 190 women in the high-risk group and 83 in the low-risk group. The high-risk group was slightly older: 57 years compared with 47 years (P=.045); 21.7% of low-risk women had abnormal anal cytology compared with 41.2% of high-risk women (P=.006). High-risk HPV was detected in the anal canal of 1.2% of the low-risk group compared with 20.8% of the high-risk group (PHuman immunodeficiency virus-negative women with a history of lower genital tract neoplasia are more likely to have positive anal cytology, anal high-risk HPV, and anal intraepithelial neoplasia. Anal cancer screening should be considered for these high-risk women. II.

  10. Matemática informal y sentido numérico en escolares de priemr ciclo de E. Primaria

    OpenAIRE

    Adrián, Cristina; Jiménez-Fanjul, Noelia; Maz-Machado, Alexander; Bracho López, Rafael; García, Teresa

    2012-01-01

    Presentamos un avance de los resultados de una investigación sobre el sentido númerico en alumnos y alumnas de primero y segundo de Educación Primaria de la provincia de Córdoba. Se utilizó un test estandarizado y validado internacionalmente TEMA-3. Los niños y niñas manifestaron un alto grado de desarrollo del sentido numérico en la matemática informal.

  11. Análisis de la atención primaria del adulto mayor en una Residencia Gerontológica de la ciudad de Guayaquil. Propuesta de un modelo de atención primaria.

    OpenAIRE

    Ruíz Cáceres, Guadalupe del Rosario

    2015-01-01

    Esta investigación tiene como objetivo general analizar la atención primaria del adulto mayor en una residencia gerontológica de la ciudad de Guayaquil y como parte de sus objetivos específicos el proponer un modelo de atención de servicios de salud para adultos mayores en cuanto a la organización, los servicios y el presupuesto, así como sus indicadores de evaluación. La metodología fue de estudio de caso, para ello se analizó la situación en general y de salud de los residentes en ...

  12. Carcinoma adenoide quístico parotídeo: soluciones estéticas y funcionales

    Directory of Open Access Journals (Sweden)

    Raquel Villar

    2014-07-01

    Full Text Available El carcinoma adenoide quístico supone el 10-30% de las neoplasias malignas parotídeas, su tratamiento se basa en una parotidectomía que incluya el tumor con un adecuado margen de seguridad y la radioterapia postoperatoria dado que permite mejorar el control locorregional de la enfermedad. Revisamos un caso que permite exponer el manejo de las secuelas funcionales y estéticas derivadas de su tratamiento. Consideramos adecuada la reconstrucción inmediata del nervio facial cuando se encuentra clínicamente afecto o englobado por el tumor; así como suplir el defecto de volumen posparotidectomía con un colgajo local. Proponemos la anastomosis nerviosa con injerto de nervio sural de las ramas del nervio facial afectas y el relleno del defecto volumen posparotidectomía con un colgajo de fascia temporo-parietal.

  13. Educación y sensibilización en alergias alimentarias en Educación Primaria

    OpenAIRE

    Orenes Muñoz, Elena

    2016-01-01

    El presente Trabajo Final de Grado (TFG) fomenta la sensibilización y la educación de la alergia alimentaria en el alumnado del ciclo de Educación Primaria. El presente TFG presenta un programa de actividades educativas para la adquisición de hábitos saludables rutinarios para fomentar la prevención y la creación de un entorno seguro para educandos alérgicos en la comunidad educativa. Ciencias de la Alimentación Educación

  14. Memorias para armar. Las conmemoraciones del 24 de Marzo en escuelas primarias del conurbano bonaerense

    Directory of Open Access Journals (Sweden)

    Gonzalo de Amézola

    2009-01-01

    Full Text Available Este artículo se ocupa del problema del tratamiento del pasado reciente en la escuela. Describe las distintas representaciones de la última dictadura militar que se encuentran presentes en los discursos pronunciados en las conmemoraciones realizadas en 2008 para recor - dar el golpe de Estado del 24 de marzo de 1976 en escuelas primarias del partido de Malvinas Argentinas, ubicado en el Conurbano Bonae - rense. Se analiza en esos discursos la presencia de distintas narracio - nes de la memoria colectiva.

  15. PREVALENCIA DEL DÉFICIT DE ATENCIÓN E HIPERACTIVIDAD EN PERSONAS ADULTAS SEGÚN EL REGISTRO DE LAS HISTORIAS CLÍNICAS INFORMATIZADAS DE ATENCIÓN PRIMARIA

    Directory of Open Access Journals (Sweden)

    Enric Aragonès

    2010-01-01

    Full Text Available Fundamento:El TDAH en adultos no es infrecuente y, según datos epidemiológicos recientes, tiene una prevalencia poblacional del 3-4%. Sin embargo, existe un gran desconocimiento sobre este trastorno entre los médicos, particularmente en atención primaria. El objetivo de este trabajo es determinar la prevalencia del diagnóstico registrado de TDAH en adultos y la proporción de pacientes con prescripción farmacológica para este trastorno en atención primaria. Métodos:Se trata de un estudio transversal sobre las bases de datos de las historias clínicas electrónicas de atención primaria. La población diana son los adultos (18-44 años adscritos a centros de salud del Instituto Catalán de la Salud (n=2.452.107. Hemos obtenido la proporción de pacientes con diagnóstico de TDAH (código F90/CIE-10 en la lista de problemas activos, y la proporción de pacientes con prescripción activa de un fármaco específico para el TDAH en adultos: metilfenidato, metilfenidato de liberación prolongada o atomoxetina. Resultados:La prevalencia de TDAH registrado es del 0,04% (0,07% en hombres; 0,02% en mujeres. Los pacientes con prescripción para TDAH son el 0,07% (0,08% en hombres; 0,05% en mujeres. El 32,05% de los TDAH tenían prescripción específica. Conclusión:El diagnóstico en adultos de TDAH y el tratamiento específico son extremadamente bajos en atención primaria. Estos resultados contrastan con los datos poblacionales: el TDAH registrado es 1/85 de la prevalencia poblacional.

  16. [Crosssectional survey of human papilloma virus subtype distribution and cervical intraepithelial neoplasia in Shenzhen].

    Science.gov (United States)

    Liang, Ling-yun; Du, Hui; Wang, Chun; Zhang, Wei; Chen, Yun; Qu, Xin-feng; Yang, Bin; Wu, Bo; Wu, Ruo-song; Belinson, Jerome L; Wu, Rui-fang

    2013-02-18

    To investigate the prevalence of human papilloma virus (HPV) infection and cervical intraepithelial neoplasia (CIN) and pathogenecity of the HPV subtyping and virus loads in Shenzhen district. In the study, 10 000 sexually active women from Shenzhen city and rural areas around were screened for cervical cancer, and all the cases were examined with cytology tests and several kinds of high risk HPV (HR-HPV) tests. Those with cytology ≥atypical squamous cells of undetermined sign (ASC-US) or positive HPV results underwent colposcopy with biopsy for a pathological diagnosis. The average age of this study population was 38.9 years. The total prevalence of HPV infection was 16.6%, with age-specific prevalence increasing with age. The morbidity rate of the low grade cervical intraepithelial neoplasia CIN1 was 17.0%, but that with those aged ≥55 years showed a sharp drop. The morbidity rate of the high grade cervical intraepithelial neoplasia CIN2/3 was 2.6%, and was higher in the 45 to 59 years age group than in the 25 to 44 years age group. HR-HPV infection was an obvious relevant factor of CIN1 and CIN2/3, and the OR values increased as the virus loads increased, but they had different relevant HPV subtypes. We found that HPV-16, -58, -31, -33, -18 were the first five ones for CIN2/3 while HPV-39, -58, -59, -52, -66 for CIN1. There is a high level of HPV infection and CIN in Shenzhen district. The prevalence of HPV infection has a trend to increase with age, and the people aged 45 years and more are key objects for CIN2/3 screening, with the virus load and subtyping of HR-HPV infection as indicative factors.

  17. HER2/neu (c-erbB-2) gene amplification and protein expression are rare in uterine cervical neoplasia: a tissue microarray study of 814 archival specimens

    DEFF Research Database (Denmark)

    Lesnikova, Iana; Lidang, Marianne; Hamilton-Dutoit, Stephen

    2009-01-01

    intraepithelial neoplasia (CIN)1 (n = 262), CIN2 (n = 230), CIN3 (n = 186) and invasive carcinoma (n = 136), for HER2/neu protein expression by immunohistochemistry (IHC) and for HER2/neu gene amplification by chromogenic in situ hybridization (CISH). We found moderate or strong immunohistochemical positivity...... and invasive cervical carcinoma specimens. When present, Her-2/neu positivity is more commonly seen in higher grades of cervical dysplasia and in carcinoma. However, this large TMA study shows that HER2/neu oncoprotein expression and HER2/neu gene amplification overall are uncommon events in cervical neoplasia....... This provides compelling evidence that HER2/neu plays no major role in the development and progression of cervical neoplasia....

  18. Videojuegos, televisión y rendimiento académico en alumnos de primaria

    OpenAIRE

    M. del Mar Badia Martín; Mercè Clariana Muntada; Concepción Gotzens Busquets; Ramón Cladellas Pros; Teresa Dezcallar Sáez

    2015-01-01

    El mal uso de las tecnologías puede repercutir en un menor rendimiento académico. En el presente trabajo se ha analizado la relación entre el tiempo dedicado a la televisión, uso de videojuegos, y las notas de los alumnos, en una muestra de educación primaria de Cataluña y de las Islas Baleares, participando 711 alumnos, entre 6 y 13 años. Los resultados muestran que el número de horas de televisión puede guardar una relación negativa con el rendimiento en matemáticas. Se concluye que el uso ...

  19. Música y ciencia: Un estudio de actitudes en estudiantes de Magisterio de Educación Primaria

    Directory of Open Access Journals (Sweden)

    Beatriz Mazas Gil

    2016-07-01

    Full Text Available En este trabajo se muestran resultados del estudio de actitudes sobre la enseñanza del sonido en Educación Primaria realizado con un grupo de estudiantes de Magisterio antes y después de la puesta en práctica de una secuencia de actividades. Las actividades fueron diseñadas con un enfoque integrador y una perspectiva multidisciplinar orientada a la elaboración de propuestas de enseñanza-aprendizaje globalizadas y consistentes con las distintas áreas disciplinares involucradas en Educación Primaria. Para conocer las actitudes e ideas de los futuros maestros se utiliza un cuestionario formado por 10 preguntas abiertas y 10 ítems de escala Likert de 5 puntos. En este trabajo se analizan los resultados obtenidos en los 10 ítems. Los resultados muestran que todos los grupos presentan mejoras en su actitud hacia la enseñanza del sonido. Además, resulta destacable la reducción de las diferencias existentes inicialmente entre ellos una vez realizada la intervención. Esto nos lleva a considerar que el programa realizado ha cumplido su propósito, que llevando a cabo intervenciones con un enfoque interdisciplinar pueden mejorar significativamente la actitud en los futuros maestros, lo que resulta de interés para su futura práctica docente.

  20. Uso de las TIC en estudiantes de quinto y sexto grado de educación primaria

    Directory of Open Access Journals (Sweden)

    Marisol Villegas Pérez

    2017-03-01

    Full Text Available El propósito de este estudio es identificar la percepción de los alumnos de quinto y sexto de educación primaria, en escuelas públicas, sobre sus competencias en el uso de las tecnologías de la información y la comunicación (TIC e indagar si existen diferencias en cuanto al sexo y a tener computadora y acceso a internet en casa. La metodología fue cuantitativa no experimental transeccional y la muestra se conformó de 201 estudiantes de escuelas primarias públicas: 51.6% corresponde a alumnos de quinto y 48.4, de sexto; de estos, 52.6 eran niños y 47.4, niñas. Los instrumentos empleados fueron dos encuestas con escala tipo Likert con cinco opciones de respuesta. La primera encuesta midió el uso de las TIC en la vida diaria y la segunda, el uso de las TIC en la escuela. Los resultados muestran que los estudiantes hacen uso moderado de las TIC y no hay diferencias significativas en cuanto al sexo y a tener computadora en casa, o no, pero sí en el acceso a internet. El estudio concluye que los alumnos utilizan las TIC más para actividades de esparcimiento que para labores escolares y que sus competencias al respecto son limitadas.

  1. American Gastroenterological Association guidelines are inaccurate in detecting pancreatic cysts with advanced neoplasia: a clinicopathologic study of 225 patients with supporting molecular data.

    Science.gov (United States)

    Singhi, Aatur D; Zeh, Herbert J; Brand, Randall E; Nikiforova, Marina N; Chennat, Jennifer S; Fasanella, Kenneth E; Khalid, Asif; Papachristou, Georgios I; Slivka, Adam; Hogg, Melissa; Lee, Kenneth K; Tsung, Allan; Zureikat, Amer H; McGrath, Kevin

    2016-06-01

    The American Gastroenterological Association (AGA) recently reported evidence-based guidelines for the management of asymptomatic neoplastic pancreatic cysts. These guidelines advocate a higher threshold for surgical resection than prior guidelines and imaging surveillance for a considerable number of patients with pancreatic cysts. The aims of this study were to assess the accuracy of the AGA guidelines in detecting advanced neoplasia and present an alternative approach to pancreatic cysts. The study population consisted of 225 patients who underwent EUS-guided FNA for pancreatic cysts between January 2014 and May 2015. For each patient, clinical findings, EUS features, cytopathology results, carcinoembryonic antigen analysis, and molecular testing of pancreatic cyst fluid were reviewed. Molecular testing included the assessment of hotspot mutations and deletions for KRAS, GNAS, VHL, TP53, PIK3CA, and PTEN. Diagnostic pathology results were available for 41 patients (18%), with 13 (6%) harboring advanced neoplasia. Among these cases, the AGA guidelines identified advanced neoplasia with 62% sensitivity, 79% specificity, 57% positive predictive value, and 82% negative predictive value. Moreover, the AGA guidelines missed 45% of intraductal papillary mucinous neoplasms with adenocarcinoma or high-grade dysplasia. For cases without confirmatory pathology, 27 of 184 patients (15%) with serous cystadenomas (SCAs) based on EUS findings and/or VHL alterations would continue magnetic resonance imaging (MRI) surveillance. In comparison, a novel algorithmic pathway using molecular testing of pancreatic cyst fluid detected advanced neoplasias with 100% sensitivity, 90% specificity, 79% positive predictive value, and 100% negative predictive value. The AGA guidelines were inaccurate in detecting pancreatic cysts with advanced neoplasia. Furthermore, because the AGA guidelines manage all neoplastic cysts similarly, patients with SCAs will continue to undergo unnecessary MRI

  2. THE 3-GROUP METAPHASE AS A MORPHOLOGIC INDICATOR OF HIGH-PLOIDY CELLS IN CERVICAL INTRAEPITHELIAL NEOPLASIA

    NARCIS (Netherlands)

    PIETERS, WJLM; KOUDSTAAL, J; PLOEMZAAYER, JJ; Janssens, J; OOSTERHUIS, JW

    There is a need for additional morphologic criteria to improve the value of histologic classification for the prediction of the biologic behavior of cervical intraepithelial neoplasia (CIN). Representative slides from 72 cone specimens containing CIN were examined to study the correlation between

  3. Evidence supporting see-and-treat management of cervical intraepithelial neoplasia: a systematic review and meta-analysis

    NARCIS (Netherlands)

    Ebisch, R.M.F.; Rovers, M.M.; Bosgraaf, R.P.; Pluijm-Schouten, H.W. van der; Melchers, W.J.; Akker, P.A.J. van den; Massuger, L.F.; Bekkers, R.L.M.

    2015-01-01

    BACKGROUND: Studies of see-and-treat management of cervical intraepithelial neoplasia (CIN) vary in their inclusion criteria, resulting in a broad range of overtreatment rates. OBJECTIVES: To determine overtreatment rates in see-and-treat management of women referred for colposcopy because of

  4. Single-session endoscopic resection and focal radiofrequency ablation for short-segment Barrett's esophagus with early neoplasia

    NARCIS (Netherlands)

    Barret, Maximilien; Belghazi, Kamar; Weusten, Bas L. A. M.; Bergman, Jacques J. G. H. M.; Pouw, Roos E.

    2016-01-01

    The management of early neoplasia in Barrett's esophagus (BE) requires endoscopic resection of visible lesions, followed by radiofrequency ablation (RFA) of the remaining BE. We evaluated the safety and efficacy of combining endoscopic resection and focal RFA in a single endoscopic session in

  5. ¿Existe violencia escolar en Educación Infantil y Primaria?: una propuesta para su evaluación y gestión

    Directory of Open Access Journals (Sweden)

    Natalia Albaladejo-Blázquez

    2013-10-01

    Full Text Available La tradición investigadora de la violencia escolar se ha centrado fundamentalmente en los últimos ciclos de Educación Primaria y en la Educación Secundaria Obligatoria, abordándose muy poco la presencia, características, evaluación e intervención de los problemas interpersonales en edades tempranas. El objetivo del presente estudio es la construcción y validación de un cuestionario que identifique el inicio y las formas más frecuentes de violencia escolar en los primeros años de escolarización para diseñar programas de prevención eficaces. Los participantes fueron 195 niños/as del último curso de educación infantil y primer ciclo de educación primaria. La investigación realizada ha mostrado que el instrumento denominado Cuestionario de Evaluación de Violencia Escolar en Infantil y Primaria (CEVEIP presenta adecuadas propiedades psicométricas. El instrumento consta de 27 ítems en formato de autoinforme que evalúa siete tipologías de violencia que se dan en el contexto escolar en edades tempranas desde tres perspectivas: violencia observada, vivida y realizada. Los resultados ponen de manifiesto que el comportamiento violento está presente desde los primeros años de escolarización, siendo éste de baja o moderada frecuencia e intensidad. Estos niveles de violencia podrían ser aprovechados en el ámbito educativo para una gestión más positiva en el desarrollo personal del alumno/a.

  6. Una propuesa didáctica con materiales manipulativos para la educación primaria

    OpenAIRE

    Martín, Sagrario

    2012-01-01

    Este artículo trata sobre una experiencia del área de Matemáticas en segundo ciclo de primaria. El objetivo es enseñar y aprender los contenidos de dicha área partiendo de la manipulación de materiales específicos, como juegos, figuras para geometría, fichas para la numeración, relojes de papel… que hemos creado y llevado al aula en el curso escolar 2010/11. La principal conclusión es que los niños se han sentido enormemente motivados en la presentación de los contenidos, que han adquirido de...

  7. Conocimiento Especializado en Geometría en un aula de 5º de Primaria

    OpenAIRE

    Liñán García, María del Mar

    2017-01-01

    La intención inicial de este trabajo de investigación —en el marco del proyecto Caracterización del Conocimiento Especializado del Profesor de Matemáticas (EDU20I3-44047P), financiado por el Ministerio de Economía y Competividad— era caracterizar el conocimiento especializado de una maestra cuando enseña Geometría en su aula de quinto de primaria; sin embargo, influida por mi formación, ini sensibilidad teórica y mi trabajo como investigadora en Didáctica de la Matemática y formadora de futur...

  8. Neoplasia in 125 donkeys (Equus asinus): literature review and a survey of five veterinary schools in the United States and Canada.

    Science.gov (United States)

    Davis, Corrine R; Valentine, Beth A; Gordon, Emma; McDonough, Sean P; Schaffer, Paula A; Allen, Andrew L; Pesavento, Patricia

    2016-11-01

    A diagnosis of neoplasia was noted in 125 of 357 donkeys (35%) in our review of medical records from 5 veterinary schools in the United States and Canada. Equine sarcoid was the most common tumor in our study, accounting for 72% of all tumors and 82% of cutaneous tumors. Soft-tissue sarcomas were the second most common skin tumors. All other types of neoplasia were rare. Important differences in the occurrence of neoplasia in donkeys compared to horses included the rarity or absence of squamous cell carcinoma in any organ system and gray horse melanoma. Lymphosarcoma, the most common malignant tumor in horses, appears to be very rare in donkeys. We report several tumors in donkeys including melanocytoma, peripheral nerve sheath tumor, and gastrointestinal stromal tumor. Our data demonstrate commonalities as well as differences in neoplastic diseases of donkeys and horses. Understanding differences in carcinogenesis among these 2 closely related species can inform researchers pursuing pathogenic mechanisms of equine disease and inform veterinary diagnosticians regarding tumor prevalence. © 2016 The Author(s).

  9. Anal intraepitelial neoplasia: a narrative review

    Directory of Open Access Journals (Sweden)

    Garazi Elorza

    2016-01-01

    Full Text Available Anal intraepitelial neoplasia (AIN constitutes a major health problem in certain risk groups, such as patients with immunosuppression of varied origin, males who have sexual relations with other males, and females with a previous history of vaginal or cervical abnormalities in cytology. Its relationship with the human papillomavirus (HPV infection has been well documented; however, many of the factors involved in the progression and regression of the viral infection to dysplasia and anal carcinoma are unknown. AIN can be diagnosed through cytology of the anal canal or biopsy guided by high-resolution anoscopy. However, the need for these techniques in high-risk groups remains controversial. Treatment depends on the risk factors and given the high morbidity and high recurrence rates the utility of the different local treatments is still a subject of debate. Surgical biopsy is justified only in the case of progression suggesting lesions. The role of the vaccination in high-risk patients as primary prevention has been debated by different groups. However, there is no general consensus on its use or on the need for screening this population.

  10. Equidad en la educación preescolar, primaria, secundaria y media en el Distrito Capital

    Directory of Open Access Journals (Sweden)

    Torres Núñez Viviana Luz

    2008-12-01

    Full Text Available El presente trabajo identifica la población que asiste a la educación pública en los niveles de preescolar, primaria, secundaria y media en Bogotá desde dos perspectivas: la geográfica, que contrasta los porcentajes de pobreza por localidad frente a la asistencia a la educación pública y privada; y la perspectiva individual, que estima los criterios de equidad horizontal y vertical sobre la población entre 5 y 17 años con ingreso per cápita estimado.

  11. Factores asociados a recibir la vacunación antigripal en profesionales de atención primaria

    OpenAIRE

    Josep Montserrat-Capdevila; Pere Godoy; Josep Ramon Marsal; Ferran Barbé-Illa

    2015-01-01

    Objetivo: Conocer la cobertura vacunal antigripal en profesionales de atención primaria y determinar los factores asociados a la vacunación (temporada 2013-2014). Métodos: Estudio transversal realizado a 287 profesionales que cumplimentaron un cuestionario que incluía preguntas sobre conocimientos, creencias y actitudes frente la gripe y la vacunación. Se determinó la cobertura y aquellas variables asociadas a recibir la vacunación, utilizando modelos de regresión logística no condicional....

  12. Improvement over time in outcomes for patients undergoing endoscopic therapy for Barrett's oesophagus-related neoplasia: 6-year experience from the first 500 patients treated in the UK patient registry.

    LENUS (Irish Health Repository)

    Haidry, R J

    2015-08-01

    Barrett\\'s oesophagus (BE) is a pre-malignant condition leading to oesophageal adenocarcinoma (OAC). Treatment of neoplasia at an early stage is desirable. Combined endoscopic mucosal resection (EMR) followed by radiofrequency ablation (RFA) is an alternative to surgery for patients with BE-related neoplasia.

  13. EL DISCURSO DE LOS PROFESIONALES DE ATENCIÓN PRIMARIA DE LA COMUNIDAD DE MADRID SOBRE EL TRABAJO CON GRUPOS: SENTIDO, FINALIDADES Y ÁMBITOS DE INTERVENCIÓN

    Directory of Open Access Journals (Sweden)

    Juan Carlos Duro Martínez

    2002-01-01

    Full Text Available Fundamento: La Educación para la salud con grupos es una actividad cada vez más importante en atención primaria. Con el objetivo de contribuir a su desarrollo, esta investigación se plantea conocer los discursos de los profesionales sanitarios sobre las prácticas grupales y específicamente sobre su sentido, finalidades y ámbitos de aplicación. Métodos: Desde una perspectiva cualitativa-estructural se realizaron cuatro grupos de discusión y cuatro entrevistas abiertas con médicos generales, especialistas en Pediatría, en Medicina Familiar y Comunitaria, Enfermería y Trabajo Social, de las Áreas de Atención Primaria de la Comunidad de Madrid. Resultados: Los discursos de los profesionales de atención primaria sobre los grupos se inscriben dentro de las actividades de educación para la salud, siendo ésta una actividad supeditada a la consulta individual. Para hacer grupos los profesionales incluyen argumentos del orden de la jerarquía, eficiencia, eficacia y satisfacción personal. Los principales colectivos objeto del trabajo en grupo son, por este orden, los pacientes crónicos (hipertensos y diabéticos, mujeres (perimenopaúsicas, con malestar general, etc., escolares y profesores, asociaciones de la comunidad y cuidadores de enfermos crónicos. Conclusiones: Los profesionales de atención primaria mayoritariamente consideran el trabajo con grupos como algo marginal cuya finalidad principal sería el ahorro y, subsidiariamente, la Educación para la salud. Se realizan básicamente con pacientes crónicos y mujeres, planteándose el trabajo comunitario en un segundo término.

  14. Programa de Inglés Enfocado en el Uso de Recursos Materiales Audiovisuales para Estudiantes de Tercer Grado de Primaria de Una Institución Educativa Particular del Distrito de Miraflores

    OpenAIRE

    CHÁVEZ AOJALLA, CARLOS ENRIQUE

    2016-01-01

    El objetivo principal de la siguiente investigación fue evaluar los efectos en el aprendizaje del idioma inglés en estudiantes de tercer grado de primaria de una escuela particular del distrito de Miraflores al aplicar un programa de ingles basado en el uso de recursos materiales audiovisuales. La muestra estuvo conformada por 32 niños y niñas de tercer grado de primaria; 16 estudiantes formaron parte del grupo control y 16 estudiantes del grupo experimental. El instrumento de evaluación f...

  15. Autoestima y agresividad en estudiantes de quinto grado de educación primaria de la institución educativa estatal "Pedro Adolfo Labarthe", distrito La Victoria, UGEL 03 San Miguel 2015.

    OpenAIRE

    Pariona Martínez, Magaly

    2015-01-01

    Este estudio responde al objeto determinar si existe relación significativa de la autoestima con la agresividad en estudiantes de quinto grado de educación primaria de la Institución Educativa estatal “Pedro Adolfo Labarthe”, distrito la Victoria, UGEL 03 San Miguel, 2015. El interés de la presente investigación es establecer la relación entre los factores emocionales – particularmente la autoestima- y la agresividad en estudiantes de quinto grado de educación primaria, describir cómo ha sido...

  16. Conocimientos tecnológicos, pedagógicos y disciplinares del profesorado de Primaria

    Directory of Open Access Journals (Sweden)

    Rosabel Roig Villa

    2015-07-01

    Full Text Available La emergencia de las tecnologías de información y comunicación (TIC plantea nuevos desafíos educativos al profesorado, a los cuales puede responder desde un modelo de formación coherente. El propósito de este estudio es analizar los conocimientos tecnológicos, pedagógicos y disciplinares del profesorado de Educación Primaria, necesarios para la integración de las TIC en la labor docente. Para ello, se llevó a cabo una investigación con una metodología cuantitativa de carácter no experimental en la que participaron 224 profesores de Educación Infantil y Primaria de la provincia de Alicante. Los resultados mostraron que los docentes poseen mayores conocimientos pedagógicos y disciplinares que tecnológicos, lo que conlleva a escasos conocimientos para la integración de las TIC en la labor docente. Se constataron, además, diferencias significativas entre el género y los años de experiencia docente, y la relación entre el uso lúdico de la tecnología y los conocimientos sobre sus aspectos fundamentales. Según los resultados obtenidos, se corrobora la necesidad de una alfabetización digital del profesorado abordada no solo desde una formación tecnológica, sino también pedagógica y disciplinar de forma global. Ello responde al modelo TPACK (Technological, Pedagogical and Content Knowledge, el cual se contempla como un marco de referencia a tener en cuenta por lo que respecta al desarrollo profesional del profesorado y su vinculación a los procesos de enseñanza-aprendizaje en el aula donde las TIC estén presentes.

  17. IL PROCESSO DI PRODUZIONE SCRITTA: LA COESIONE VERBALE IN TESTI DI SCUOLA PRIMARIA

    Directory of Open Access Journals (Sweden)

    Fabiana Rosi

    2015-02-01

    Full Text Available Una delle principali difficoltà che incontrano i bambini della scuola primaria nella produzione scritta riguarda la coesione verbale, ovvero il mantenimento lungo il testo della dimensione temporale inizialmente selezionata per riportare gli eventi. L’articolo esamina questo specifico tipo di competenza testuale negli alunni di sei classi del secondo ciclo della scuola primaria, tre delle quali hanno partecipato alla sperimentazione educativa sulla produzione di testi scritti “Osservare l’interlingua”. Il confronto fra i dati raccolti all’inizio e alla fine dell’anno scolastico mostra una riduzione dei salti immotivati da un tempo verbale all’altro, definiti shift temporali, nei testi prodotti nelle classi del campione sperimentale in misura maggiore rispetto a quelle di controllo e sottolinea gli effetti positivi, a breve e lungo termine, di una didattica task-based condotta con approccio inclusivo, cooperativo ed attivo.  The process of writing: verb cohesion in primary school textsOne of principal difficulties in producing written texts for primary school pupils concerns verb cohesion, i.e. maintaining the temporal dimension initially chosen for expressing events throughout the text. The paper examines this specific textual competence in pupils from six classes within second cycle of primary school. Three of these classes were involved in the “Observing interlanguage” project focused on written production. The comparison of data collected at the beginning and the end of school year shows a decrease in temporal shifts (transitions from one verb tense to another in the texts produced by the students involved in the project with regard to the control group. These findings highlight the positive effects, both short-term and long-term, of task-based teaching through an inclusive, cooperative and active approach. 

  18. Apendagitis epiploica primaria: Clínica y evolución de 73 casos

    Directory of Open Access Journals (Sweden)

    Graciela M Vázquez

    2014-12-01

    Full Text Available La apendagitis epiploica primaria es una enfermedad relativamente infrecuente dentro de los diagnósticos diferenciales del abdomen agudo. Describimos las características clínicas y evolución de una serie de 73 casos de apendagitis epiploica primaria. Se realizó una búsqueda de imágenes ecográficas y tomográficas con diagnóstico de apendagitis en el sistema de información hospitalario electrónico del Hospital Alemán entre abril del 2007 y julio del 2013 y posteriormente se revisaron sus historias clínicas. Se incluyeron 73 casos; la edad promedio fue de 45 años (± 16, 54 (74% eran varones. El motivo de consulta fue dolor abdominal: en fosa ilíaca izquierda en 65 (el 89% de los casos; en fosa ilíaca derecha en seis (8% y en otras localizaciones en dos (3%. Se les realizó ecografía abdominal a 44 (60%, tomografía computarizada a 21 (29%, y ambos estudios a 8 (11%. En el 49% de los casos se solicitó interconsulta con el servicio de cirugía. Recibieron tratamiento con antibióticos 15 (21% pacientes, de los cuales el 73% fue indicado por un médico clínico. Recibieron tratamiento ambulatorio con antiinflamatorios no esteroides 67 (92%; dos requirieron cirugía laparoscópica, dos internación y dos opiáceos. La apendagitis epiploica es infrecuente dentro de los diagnósticos diferenciales de abdomen agudo, pero es una entidad que no debe ser desconocida por los médicos para prevenir intervenciones innecesarias y el uso excesivo de antibióticos.

  19. Las estrategias didácticas en la formación de docentes de educación primaria

    Directory of Open Access Journals (Sweden)

    Wilfredo Gonzaga Martínez

    2005-01-01

    Full Text Available El artículo tiene como propósito dar a conocer los resultados de un estudio sobre el proceso didáctico y la incorporación de estrategias innovadoras en los procesos de enseñanza y aprendizaje que se llevan a cabo en el desarrollo de los cursos que conforman el área pedagógica del plan de estudio, para la formación de docentes de Educación Primaria, en la Sede de Occidente de la Universidad de Costa Rica. Los cursos que se consideraron fueron: Introducción a la pedagogía, Didáctica General, Principios de Curriculum, Investigación Educativa, Psicología Educativa, Ciencias en la Educación Primaria, Práctica Docente y Evaluación de los Aprendizajes. La investigación se orientó con el siguiente problema general: ¿Cuáles son las estrategias didácticas en la enseñanza del área pedagógica, aplicadas en la formación inicial de docentes para la Educación Primaria en la Sede de Occidente de la Universidad de Costa Rica? En el estudio se analizaron y se confrontaron los programas de los cursos mencionados, considerando las estrategias didácticas que se aplican para su desarrollo, según el criterio de docentes y alumnos. En este análisis se describe la coherencia entre estos dos aspectos, las tendencias pedagógicas que subyacen en las estrategias didácticas y las innovaciones que se desarrollan como parte de los procesos de enseñanza y aprendizaje. El proceso investigativo demuestra que el plan de estudio considera como referencia pedagógica un enfoque humanista; mientras que los programas de los cursos y la práctica docente no logran desligarse de la didáctica tradicional, con tendencia a incorporar aspectos del Constructivismo y de la Pedagogía Crítica. En el estudio no se logró apreciar la incorporación de estrategias didácticas innovadoras de manera significativa.

  20. Referentes históricos del desempeño profesional. Caso de estudio de los maestros que enseñan en la educación básica primaria en Colombia.

    OpenAIRE

    Caicedo Villamizar, Surgei Bolivia; Alvarez Acosta, Hugandy; Hernández Pérez, Caridad

    2015-01-01

    Se realiza una revisión sobre los referentes históricos del desempeño profesional y desempeño profesional docente, que permiten dar soporte de análisis al desempeño profesional pedagógico del docente en la educación básica primaria actual de Colombia. Se presentan los referentes históricos de la formación de docentes en Colombia y las políticas emanadas por el gobierno para mejorar la incorporación de las TIC en los procesos educativos de básica primaria. A review of the theoretical framew...

  1. Osteopatía hipertrófica secundaria a metástasis pulmonar de carcinoma mamario

    OpenAIRE

    Correa Salgado, Ricardo Andrés; Giraldo Villegas, Juan Carlos

    2015-01-01

    Propósitos: este artículo pretende reportar los hallazgos de un caso clínico de osteopatía hipertrófica. Tema: la osteopatía hipertrófica es un raro desorden paraneoplásico, asociado con el sobrecrecimiento doloroso del periostio de los huesos largos, normalmente desencadenado por neoplasias primarias o metastásicas de pulmón. Desarrollo: se presenta el caso de un rottweiler, de 12 años, con osteopatía hipertrófica asociada con metástasis pulmonar de un carcinoma mamario. Conclusiones: se com...

  2. Perceived Health-Related Quality of Life in Women With Vulvar Neoplasia: A Cross Sectional Study.

    Science.gov (United States)

    Kobleder, Andrea; Nikolic, Nataša; Hechinger, Mareike; Denhaerynck, Kris; Hampl, Monika; Mueller, Michael D; Senn, Beate

    2016-09-01

    The aim of the study was to determine health-related quality of life (HRQoL) of women with surgically treated vulvar intraepithelial neoplasia (VIN) and vulvar cancer (VC) during the first week after hospital discharge. Further objectives were to investigate differences between women with VIN and VC as well as to examine whether correlations exist between women's symptom experience and HRQoL. This cross-sectional study was conducted in 8 hospitals in Germany and Switzerland. Women with VIN and VC rated HRQoL with the validated German Short-Form 36. Differences between HRQoL in women with VIN and VC were tested with Wilcoxon rank-sum score. The WOMen with vulvAr Neoplasia (WOMAN) - Patient reported Outcome (PRO) self-report instrument was used to measure women's symptom experience. Correlations between symptoms and HRQoL were calculated using Spearman correlation coefficient. Women with VIN and VC (n = 65) reported lower HRQoL in physical aspects (Physical Component Summary [PCS], 34.9) than that in mental aspects (Mental Component Summary, 40.5). Women with VC had lower HRQoL than women with VIN, as manifested by significant differences concerning the dimensions of "physical functioning" and "role-physical." "Difficulties in daily life" as a distressing symptom correlated with MCS and PCS. Wound-related symptoms correlated with PCS and psychosocial symptoms/issues with MCS. Analysis showed that women with vulvar neoplasia reported lower HRQoL in the physical and mental dimensions 1 week after discharge than comparable studies referring to months or years after surgery. Health-related quality of life is influenced by physical impairment because physical symptoms are prevalent 1 week after discharge. Patient education should focus on symptom management in an early postsurgical phase to enhance women's HRQoL.

  3. O papel da neutropenia no prognóstico do doente oncológico com pneumonia adquirida na comunidade

    Directory of Open Access Journals (Sweden)

    S. Aliberti

    2009-07-01

    Full Text Available Resumo: A doença infecciosa contribui para uma elevada morbilidade e mortalidade no doente oncológico, representando a pneumonia adquirida na comunidade a mais frequente.O desenvolvimento de PAC no doente neoplásico parece advir da modificação de mecanismos de defesa imunitária resultante, quer da patologia maligna, quer do tratamento oncológico. O risco de infecção relacionada com o tipo de neoplasia pode associar-se ao défice de imunidade humoral, celular ou do número de neutrófilos. As doenças hematológicas malignas podem predispor o doente às infecções devido à substituição da medula por células neoplásicas. Consequentemente, estes doentes têm neutropenia funcional, apesar de apresentarem, muitas vezes, um número normal ou aumentado de neutrófilos. Por outro lado, estes doentes podem ter neutropenia como efeito secundário da quimioterapia e/ou radioterapia (neutropenia absoluta.A gravidade da neutropenia foi considerada como principal factor de risco isolado no doente neoplásico, com particular relevância se o número de neutrófilos ≤500cel/mm3.A mortalidade global atribuída à neutropenia febril no doente neoplásico é de 30–50%. Nas últimas décadas, o tratamento das infecções na população oncológica foi direccionado, primariamente, para o manuseamento da neutropenia febril, devido ao facto de o local da infecção não ser determinado em 50–80% dos casos.As guidelines da American Thoracic Society de 2001 utilizavam a neutropenia para identificar os quadros mais graves de PAC nos doentes oncológicos. Os doen tes com patologia hematológica e neutropenia funcional ou indivíduos com qualquer tipo de neoplasia e neutropenia absoluta foram excluídos das referidas guidelines. A decisão de incluir doentes com tumores sólidos não neutropénicos foi baseada, apenas, na opinião de

  4. O papel da neutropenia no prognóstico do doente oncológico com pneumonia adquirida na comunidade** Eur Respir J 2009; 33:142-147

    Directory of Open Access Journals (Sweden)

    S. Aliberti

    2009-07-01

    Full Text Available Resumo: A doença infecciosa contribui para uma elevada morbilidade e mortalidade no doente oncológico, representando a pneumonia adquirida na comunidade a mais frequente.O desenvolvimento de PAC no doente neoplásico pa-rece advir da modificação de mecanismos de defesa imunitária resultante, quer da patologia maligna, quer do tratamento oncológico. O risco de infecção relacionada com o tipo de neoplasia pode associarse ao défice de imunidade humoral, celular ou do número de neutrófilos. As doenças hematológicas malignas podem predispor o doente às infecções devido à substituição da medula por células neoplásicas. Consequentemente, estes doentes têm neutropenia funcional, apesar de apresentarem, muitas vezes, um número normal ou aumentado de neutrófilos. Por outro lado, estes doentes podem ter neutropenia como efeito secundário da quimioterapia e/ou radioterapia (neutropenia absoluta.A gravidade da neutropenia foi considerada como principal factor de risco isolado no doente neoplásico, com particular relevância se o número de neutrófilos ≤500cel/mm3.A mortalidade global atribuída à neutropenia febril no doente neoplásico é de 30-50%. Nas últimas décadas, o tratamento das infecções na população oncológica foi direccionado, primariamente, para o manuseamento da neutropenia febril, devido ao facto de o local da infecção não ser determinado em 50-80% dos casos. As guidelines da American Thoracic Society de 2001 utilizavam a neutropenia para identificar os quadros mais graves de PAC nos doentes oncológicos. Os doentes com patologia hematológica e neutropenia funcional ou indivíduos com qualquer tipo de neoplasia e neutropenia absoluta foram excluídos das referidas guidelines. A decisão de incluir doentes com tumores sólidos não neutropénicos foi baseada, apenas, na opinião de especialistas

  5. Radiation-induced intestinal neoplasia in a genetically-predisposed mouse (Min)

    International Nuclear Information System (INIS)

    Ellender, M.; Larder, S.M.; Harrison, J.D.; Cox, R.; Silver, A.R.J.

    1997-01-01

    A mouse lineage with inherited predisposition to multiple intestinal neoplasia (min) has been proposed as a model to study human colorectal cancer. Min mice are heterozygous for the adenomatous polyposis coli (Apc) gene implicated in human familial adenomatous polyposis (FAP). There is an increased risk of intestinal cancer in humans following radiation exposure and the min mouse model may be used to further our understanding of the molecular mechanisms involved. The present study showed a 2 Gy dose of x-rays doubles the tumour numbers in the murine gastrointestinal tract of F1 min heterozygotes. The distribution of tumours through the gut was also recorded. (authors)

  6. Mielopatia necrotizante e neoplasias: registro clinico-patologico de dois casos

    Directory of Open Access Journals (Sweden)

    Marcos R. G. de Freitas

    1983-06-01

    Full Text Available São relatados dois casos de mielopatia transversa subaguda associada a tumores malignos. O primeiro paciente apresentava neoplasia de células reticulares histiocitárias e o segundo, carcinoma renal. Os autores fazem revisão dos casos similares descritos na literatura. As alterações anátomo-patológicas medulares encontradas foram semelhantes às descritas nos relatos prévios, sendo que no primeiro caso havia também intenso infiltrado inflamatório perivascular e a presença de astrócitos bizarros. Tais alterações encontradas sugerem ser esta afecção de natureza viral.

  7. Evaluación de la efectividad de un programa de mindfulness y autocompasión para reducir el estrés y prevenir el burnout en profesionales sanitarios de atención primaria

    OpenAIRE

    Gloria Aranda Auserón; M. Rosario Elcuaz Viscarret; Carmen Fuertes Goñi; Victoria Güeto Rubio; Pablo Pascual Pascual; Enrique Sainz de Murieta García de Galdeano

    2018-01-01

    Objetivo: Evaluar la efectividad de un programa de mindfulness y autocompasión sobre los niveles de estrés y burnout en profesionales sanitarios de atención primaria. Diseño: Ensayo clínico controlado aleatorizado. Participantes y emplazamiento: Se ofertó entrenamiento en mindfulness a los 1.281 profesionales sanitarios de atención primaria de Navarra y aceptaron 48. Se asignaron por sorteo 25 participantes al grupo intervención, quedando los 23 restantes en el grupo control. Interve...

  8. Características clínicas de doentes com neoplasia do pulmão e neoplasias primárias síncronas ou metácronas com outras localizações Clinical characteristics of patients with lung cancer and metachronous or synchronous tumours with other locations

    Directory of Open Access Journals (Sweden)

    Inês Vaz Luís

    2010-06-01

    Full Text Available O cancro do pulmão é a causa mais comum de morte por doença oncológica. Os doentes com diagnóstico de neoplasia - qualquer que seja a localização - têm risco acrescido de desenvolver um segundo tumor. Pretendeu-se caracterizar uma população com neoplasia do pulmão e o diagnóstico síncrono ou metácrono de tumor primário com outra localização. Foi feito um estudo retrospectivo, referente ao período de 2000-2007, analisando-se os processos clínicos de doentes seguidos na Unidade de Pneumologia Oncológica do nosso hospital em que estavam referenciadas duas neoplasias. Dos doentes seguidos na Unidade (n=1046 no período referido, 4,2% (n=44 tinham evidência de duas neoplasias. A maioria (88,6% dos doentes eram homens, com idade média elevada (70,1±10 anos. Oitenta e seis por cento (n=38 tinham hábitos tabágicos e 65,4% dos doentes com registo de história familiar de neoplasia (n=26 tinham história familiar relevante (n=17. A doença oncológica manifestou-se em primeiro lugar na próstata, cólon, cabeça e pescoço ou bexiga. O cancro do pulmão foi em geral a segunda neoplasia. O intervalo de tempo médio entre a primeira e a segunda neoplasia foi de 62,9±64,9 meses (max: 240, min: 0, sendo que geralmente a segunda neoplasia foi detectada em estádio avançado. A sobrevivência média foi de 8,6±8,24 meses (max: 32; min: 1, permanecendo vivos quatro doentes. Os presentes dados levam-nos a sugerir vigilância clínica prolongada em doentes com diagnóstico prévio de cancro. Sugerimos um algoritmo que possibilite vigiar melhor estes doentes e estudo prospectivo para verificar se existem marcadores moleculares nesta população.Lung cancer is the leading form of cancer death worldwide. Cancer patients are at a high risk of developing a second cancer. The present study attempts to determine the characteristics of a population with lung cancer diagnosed with another cancer. We analysed records of patients from the

  9. Incidência de neoplasias nas doenças reumatológicas autoimunes mais prevalentes: uma revisão sistemática

    Directory of Open Access Journals (Sweden)

    Roberta Ismael Lacerda Machado

    2014-04-01

    Full Text Available O presente artigo é uma revisão sistemática da literatura que aborda a coexistência de neoplasias e doenças reumatológicas autoimunes, suas principais associações, tipos de cânceres e os possíveis fatores de riscos associados, com ênfase nos estudos de base populacional existentes, além de verificar a relação dessa ocorrência com o uso dos fármacos utilizados no tratamento de doenças autoimunes. Foi realizada uma busca de artigos científicos indexados na Cochrane/BVS, Pubmed/Medline e Scielo/Lilacs no período de 2002 a 2012. Também foi consultada a IBICT (biblioteca digital brasileira de teses e mestrados, com os descritores em português e inglês para as palavras: "Esclerose sistêmica", "Artrite reumatoide", "Lúpus Eritematoso Sistêmico" e "Síndrome de Sjögren", correlacionando cada um com o descritor AND "neoplasias". Os resultados mostraram que, na base de dados IBICT, preencheram os critérios de inclusão uma tese e uma dissertação para o descritor LES, nenhuma para AR e uma tese para SS. Na base de dados Lilacs/Scielo foram encontrados dois artigos sobre "Artrite Reumatoide" AND "neoplasias". No Pubmed/Medline, a busca inicial resultou em 118 artigos; destes, preencheram os critérios e foram secionados 41 artigos. Esta revisão observou relação entre neoplasias e as doenças reumatológicas autoimunes, tanto como fator de risco quanto de proteção, embora os mecanismos fisiopatológicos não estejam totalmente elucidados.

  10. Long-Term Risk for Noncervical Anogenital Cancer in Women with Previously Diagnosed High-Grade Cervical Intraepithelial Neoplasia

    DEFF Research Database (Denmark)

    Sand, Freja Lærke; Munk, Christian; Jensen, Signe Marie

    2016-01-01

    Background: High-risk human papillomavirus (HPV) is essential for developing high-grade cervical intraepithelial neoplasia (CIN2 and CIN3) and has also been associated with noncervical anogenital cancers. However, limited knowledge exists about the long-term risk for anal, vulvar, and vaginal...

  11. Transporter function and cyclic AMP turnover in normal colonic mucosa from patients with and without colorectal neoplasia

    DEFF Research Database (Denmark)

    Kleberg, Karen; Jensen, Gerda Majgaard; Christensen, Dan Ploug

    2012-01-01

    The pathogenesis of colorectal neoplasia is still unresolved but has been associated with alterations in epithelial clearance of xenobiotics and metabolic waste products. The aim of this study was to functionally characterize the transport of cyclic nucleotides in colonic biopsies from patients...

  12. La multimorbilidad vista desde la perspectiva de los profesionales de atención primaria

    Directory of Open Access Journals (Sweden)

    Roberto Nuño-Solinís

    2014-06-01

    Conclusiones: El aumento de la multimorbilidad es una realidad que preocupa a los profesionales de atención primaria. Los profesionales manifiestan la necesidad de disponer formación adecuada y de sistemas de ayuda a la decisión y de soporte de la práctica diaria que contemplen las situaciones y combinaciones de multimorbilidad más frecuentes. Un abordaje más efectivo de esta problemática requiere un cambio en el modelo sanitario que privilegie una visión integral del paciente, la transición de un enfoque paternalista a uno más proactivo y el desarrollo de la integración asistencial.

  13. Thyroid neoplasia following radiation therapy for Hodgkin's lymphoma

    International Nuclear Information System (INIS)

    McHenry, C.; Jarosz, H.; Calandra, D.; McCall, A.; Lawrence, A.M.; Paloyan, E.

    1987-01-01

    The question of thyroid neoplasia following high-dose radiation treatment to the neck and mediastinum for malignant neoplasms such as Hodgkin's lymphoma in children and young adults has been raised recently. Five patients, 19 to 39 years old, were operated on for thyroid neoplasms that developed following cervical and mediastinal radiation therapy for Hodgkin's lymphoma. Three patients had papillary carcinomas and two had follicular adenomas. The latency period between radiation exposure and the diagnosis of thyroid neoplasm ranged from eight to 16 years. This limited series provided strong support for the recommendation that children and young adults who are to receive high-dose radiation therapy to the head, neck, and mediastinum should receive suppressive doses of thyroxine prior to radiation therapy in order to suppress thyrotropin (thyroid-stimulating hormone) and then be maintained on a regimen of suppression permanently

  14. Enseñar a transitar desde la Educación Primaria: el proyecto profesional y vital

    Directory of Open Access Journals (Sweden)

    Cristina González Lorente

    2015-01-01

    Full Text Available Comenzar desde edades tempranas a identificar y gestionar las potencialidades y los recursos personales que tiene el alumnado, se considera uno de los pilares básicos para afrontar los diferentes cambios y desafíos que se plantean, tanto fuera como dentro del sistema educativo. Este trabajo se centra en las primeras transiciones que experimentan los estudiantes en su trayectoria académica y pretende dar consistencia y coherencia a la intervención educativa del maestro‐tutor desde la acción tutorial, para acompañar a los jóvenes en el tránsito de la Educación Primaria a la Educación Secundaria a partir de una acción orientadora centrada en la elaboración del Proyecto Profesional y Vital, entendido como construcción activa que se desarrolla a lo largo de la vida y en momentos de cambio. Hacer uso de esta herramienta en las aulas de Educación Primaria, implica comenzar un necesario proceso de descubrimiento personal (quién soy y del entorno más inmediato (dónde estoy de los estudiantes, acompañándoles en este proceso de introspección y reflexión para facilitar una plena adaptación a la nueva cultura escolar y fortalecer su capacidad de tomar decisiones autónomas y responsables a lo largo de su itinerario académico, profesional y vital.

  15. BREVE VISIÓN DE LOS PRINCIPALES PROTAGONISTAS DE LA ESCUELA INGLESA DE ATENCIÓN PRIMARIA DURANTE EL ÚLTIMO MEDIO SIGLO

    Directory of Open Access Journals (Sweden)

    Carlota Blanco Rubio

    2016-01-01

    Full Text Available El objetivo es hacer un breve repaso de las influencias, el núcleo duro de perfil clínico, la enfermería científica y el presente de la Escuela Inglesa de Atención Primaria durante los últimos sesenta años. Entendemos que la influencia intelectual más profunda fue la de Archie Cochrane. Entre los médicos de familia componentes del núcleo duro destacamos a John Fry (1922- 1994, David Metcalfe y Julian Tudor Hart. Por otra parte, Lisbeth Hockey (1918-2004, doctora en enfermería, fue la responsable durante varios años de la Unidad de Investigación en Cuidados de la Universidad de Edimburgo. Las fuentes de investigación historiográfica de la enfermería inglesa en internet son notables. Finalmente, Trisha Greenhalgh, médica de familia, investigadora y docente en la Universidad de Oxford, está lanzando a la vieja Escuela Inglesa de Atención Primaria hacia la mediana del siglo XXI.

  16. Efectividad de una intervención educativa sobre tratamiento de úlceras por presión para enfermeras de Atención Primaria.

    OpenAIRE

    Arnaldos Esteban, Marta

    2013-01-01

    El objetivo de este trabajo es evaluar la efectividad de una intervención educativa sobre tratamiento de úlceras por presión para profesionales de enfermería de Atención Primaria. Máster en Gestión Integral e Investigación de las Heridas Crónicas

  17. RELACIÓN DE LA LECTOESCRITURA CON LOS PATRONES MOTRICES EN ALUMNOS DE EDUCACIÓN PRIMARIA

    OpenAIRE

    Del-Pozo-Sánchez, María Josefa

    2012-01-01

    En el presente trabajo se ha estudiado la posible relación entre los procesos de lectoescritura y motricidad y cómo estos influyen en el rendimiento académico. Para ello se ha tomado una muestra de 33 niños en educación primaria y se les ha evaluado con una batería de pruebas dirigida a valorar su motricidad y habilidades en lectura y escritura. Los resultados obtenidos muestran que si bien existe una relación moderada entre aspectos concretos de la motricidad y la lectura, no se puede ...

  18. Pautas para el diseño de materiales educativos multimedia en educación primaria

    OpenAIRE

    Navarro Martínez, Óscar

    2016-01-01

    La elaboración de materiales educativos multimedia dirigido a alumnos de Educación Primaria tiene gran importancia en la actualidad. El diseño, principalmente de las imágenes y textos, puede influir en la eficiencia de dichos materiales en el proceso de enseñanza-aprendizaje. En esta tesis doctoral se ha analizado cómo se produce el proceso de observación visual de contenidos multimedia por parte de niños de siete y once años. El objetivo final es establecer cuáles son las pautas de diseño (g...

  19. Uso de las tic en el aula de lenguas extranjeras en educación primaria

    OpenAIRE

    Vega Vivar, Beatriz

    2016-01-01

    RESUMEN: En la actualidad vivimos inmersos en la era de la comunicación, lo que ha suscitado un gran cambio en la sociedad en cuanto a su manera de aprender y adquirir el conocimiento. Este cambio a su vez, se ha visto reflejado en la forma de enseñar de los maestros en todas las áreas ya desde la Educación Primaria e, incluso la Educación Infantil. Los alumnos de ahora se definen como “nativos digitales” ya que han nacido en la era de la comunicación, frente a los “inmigrantes digitales”, es...

  20. Neuroeducación, ansiedad y atención en alumnos de Educación Primaria

    OpenAIRE

    Betegón Blanca, Elena

    2017-01-01

    El Trabajo de Fin de Máster que se expone a continuación constituye una iniciación a la investigación educativa. El tema principal que se aborda está centrado en la búsqueda de metodologías adaptables, en niveles de Educación Primaria, que ayuden a resolver el reciente aumento de trastornos del aprendizaje y la aparición de conductas disruptivas en la población infanto-juvenil en el medio escolar. Partiendo de la fundamentación teórica sobre Neuroeducación se instalan una serie de estímulos n...

  1. Use of faecal markers in screening for colorectal neoplasia: a European group on tumor markers position paper.

    LENUS (Irish Health Repository)

    Duffy, Michael J

    2012-02-01

    Several randomized controlled trials have shown that population-based screening using faecal occult blood testing (FOBT) can reduce mortality from colorectal neoplasia. Based on this evidence, a number of countries have introduced screening for colorectal cancer (CRC) and high-risk adenoma and many others are considering its introduction. The aim of this article is to critically review the current status of faecal markers as population-based screening tests for these neoplasia. Most of the available faecal tests involve the measurement of either occult blood or a panel of DNA markers. Occult blood may be measured using either the guaiac faecal occult blood test (gFOBT) or a faecal immunochemical test (iFOBT). Although iFOBT may require a greater initial investment, they have several advantages over gFOBT, including greater analytical sensitivity and specificity. Their use results in improved clinical performance and higher uptake rates. Importantly for population screening, some of the iFOBTs can be automated and provide an adjustable cutoff for faecal haemoglobin concentration. However, samples for iFOBT, may be less stable after collection than for gFOBT. For new centres undertaking FOBT for colorectal neoplasia, the European Group on Tumour Markers recommends use of a quantitative iFOBT with an adjustable cutoff point and high throughput analysis. All participants with positive FOBT results should be offered colonoscopy. The panel recommends further research into increasing the stability of iFOBT and the development of improved and affordable DNA and proteomic-based tests, which reduce current false negative rates, simplify sample transport and enable automated analysis.

  2. High-dose-rate intracavitary brachytherapy in the management of cervical and vaginal intraepithelial neoplasia

    International Nuclear Information System (INIS)

    Ogino, Ichiro; Kitamura, Tatsuo; Okajima, Hiroyuki; Matsubara, Sho

    1998-01-01

    Purpose: To assess the effectiveness of high-dose rate intracavitary brachytherapy (HDR-ICR) in patients with grade 3 cervical intraepithelial neoplasia (CIN-3) and grade 3 vaginal intraepithelial neoplasia (VAIN-3). Methods and Materials: This was a retrospective analysis in 20 patients with CIN-3 (n = 14) or VAIN-3 (n = 6), average age 61.9 years, managed with HDR-ICR at Kanagawa Cancer Center. Two patients with CIN-3 with microinvasive foci and 11 other patients with CIN-3 were treated with HDR-ICR for cervical lesions. Six patients with CIN-3 after hysterectomy received HDR-ICR for recurrent or residual VAIN-3 lesions. One patient received radiation therapy for both CIN-3 and VAIN-3 lesions. All these patients but one were postmenopausal. Results: Seventeen patients were treated with HDR-ICR alone, and three with combined external radiation therapy. The dose was calculated at Point A located 2 cm superior to the external os and 2 cm lateral to the axis of the intrauterine tube for intact uterus. For lesions of the vaginal stump, the dose was calculated at a point 1 cm superior to the vaginal apex or 1 cm beyond vaginal mucosa. In the 14 patients treated for CIN-3 lesions, the mean total dose of HDR-ICR was 26.1 Gy (range 20-30). Six patients received HDR-ICR for VAIN-3 lesions with mean dose of 23.3 Gy (range 15-30). At follow-up (mean 90.5 months; range 13-153), 14 patients were alive and 6 had died owing to nonmalignant intercurrent disease. No patient developed recurrent disease. Rectal bleeding occurred in three patients, but this symptom subsided spontaneously. Moderate and severe vaginal reactions were noted in two patients, in whom the treatment had included the entire vagina. Conclusions: HDR-ICR can be employed as the primary management strategy for postmenopausal women with CIN-3. In intraepithelial neoplasia involving the vaginal wall after hysterectomy, HDR-ICR should be considered as an alternative to total vaginectomy

  3. Perfil de los adultos mayores usuarios de atención primaria

    Directory of Open Access Journals (Sweden)

    Fabianne de Jesus Dias de Sousa

    2017-05-01

    Full Text Available Introducción: Las proyecciones indican que Brasil será el sexto país del mundo con el mayor número de adultos mayores. El objetivo de este estudio fue caracterizar las condiciones de perfil y de vida socio-demográficos y de salud de los usuarios adultos mayores de la atención primaria de un municipio en la región amazónica del Brasil. Es oportuno porque el envejecimiento de la población está creciendo rápidamente, especialmente en países en desarrollo como el Brasil. Materiales y Métodos: Estudio transversal con una muestra de 441 individuos con edad inferior a 60 años de la población de usuarios de la atención básica en el municipio de Benevides, en la Amazonia brasileña. Os datos fueron obtenidos a través del Elder notebook, un protocolo clínico del Ministerio de la Salud. La prueba del chi-cuadrado con un nivel de significancia de 5% para explorar fue utilizada las asociaciones entre las variables de las condiciones de salud y de vida, y las variables socio-demográficas. Resultados: Se presentaron un perfil predominantemente joven adultos mayores (46.0%, que no practican actividad física (p<0.02, con condiciones crónicas y uso de drogas para inducir el sueño (p<0.05. Discusión y Conclusiones: El perfil de vida desfavorable y de salud encontrados en adultos mayores exige la adopción de medidas reforzadas, sobre la salud y los presupuestos de atención integral como un desafío para efectuar la colocación de sus necesidades, principalmente por la enfermería, en la Atención Básica de Salud en áreas más necesitadas de la región amazónica. Cómo citar este artículo: Sousa FJD, Andrade FS. Perfil de los adultos mayores usuarios de atención primaria. Rev Cuid. 2017; 8(2: 1573-81. http://dx.doi.org/10.15649/cuidarte.v8i2.376

  4. Neoplasia intraepitelial cervical en mujeres menores de 25 años

    Directory of Open Access Journals (Sweden)

    Martha María Chávez Valdivia

    2012-03-01

    Full Text Available Fundamento: aunque la incidencia de lesiones preinvasivas del cervix ha sido mayor en mujeres de la tercera a cuarta década de la vida, en los últimos años se ha encontrando un número no despreciable de mujeres menores de 25 años afectadas por este tipo de lesiones de bajo o alto grado. Objetivo: describir el comportamiento de las neoplasias intraepiteliales cervicales diagnosticadas en mujeres menores de 25 años de edad, y tratadas con radiocirugía. Métodos: estudio retrospectivo y descriptivo de 67 pacientes menores de 25 años de edad, con diagnóstico de neoplasia intraepitelial cervical y tratadas por el método de radiocirugía en el Hospital General de Cienfuegos. Se analizaron las variables: edad, tipo de NIC, grado de la NIC y presencia de VPH. Resultados: el grupo más afectado fue el de las mujeres de 21 a 25 años de edad, portador del 70,4 % de lesiones. El 86, 56 % de las lesiones fue de alto grado. Las lesiones estuvieron asociadas con elevada frecuencia (88,05 % a condiloma, evidencia histológica indirecta de la citotoxicidad por la infestación tisular del VPH. Conclusiones: La presencia de NIC en mujeres menores de 25 años de edad, se configura en nuestro medio como problema de salud. El presente estudio puede servir como sustrato para desarrollar investigaciones similares en varios lugares del país, con la finalidad de aportar evidencia global que conduzca al cambio.

  5. Notas sobre la situación de la producción primaria de arroz en Venezuela

    OpenAIRE

    Molina, Luisa Elena

    2003-01-01

    1.- Artículos Cartay, Rafael. "Los productos típicos y su reglamentación. Una tentativa de aplicación de la denominación de origen al cacao venezolano" Kalvatchev, Zlatko; Garzaro, Domingo; Guerra Cedezo, Franklin. "Theobroma Cacao L.: Un nuevo enfoque para nutrición y salud" Anido, Daniel; Gutiérrez, Alejandro. "La demanda de las calorías en Venezuela 1970-1995: Algunas evidencias empíricas" Molina, Luisa Elena. "Notas sobre la situación de la producción primaria de arroz en Ven...

  6. Frequência do carcinoma basocelular na população menor de 50 anos: estudo do serviço e revisão de literatura Frequency of basal cell carcinoma in a population younger than 50 years of age: clinical study and literature review

    Directory of Open Access Journals (Sweden)

    Ana Carolina Conde Almeida

    2009-12-01

    Full Text Available O carcinoma basocelular é a neoplasia maligna cutânea mais comum em humanos, que pode ser prevenida e diagnosticada precocemente. O propósito deste estudo é apresentar os achados clínicos e microscópicos do carcinoma basocelular na população menor de 50 anos. Realizaram-se exames microscópicos em múltiplos cortes de lesão de pele e fez-se revisão da literatura pertinente.Basal cell carcinoma is the most common type of malignant cutaneous neoplasm in humans, and it can be prevented and diagnosed early. The purpose of this study is to present clinical and microscopic findings of basal cell carcinoma in a population younger than 50 years of age. Microscopic examinations of multiple sections of skin lesion have been done, as well as a review of relevant literature.

  7. Telomere dynamics and cytogenetic changes in human hematologic neoplasias: a working hypothesis.

    Science.gov (United States)

    Ohyashiki, K; Ohyashiki, J H

    1997-03-01

    Chromosome termini, termed telomeres, provide important protection to avoid loss of master gene(s) that may exist at subtelomeric regions. Moreover, erosion of telomeres by cell division through end-replication problems resulted in telomeric-associated cytogenetic aberrations. To maintain a telomere length related to cell immortality, telomerase activity is upregulated in cancer cells, therefore, telomerase is considered to be a new marker of neoplasias. In this paper, we review and make suggestions regarding key aspects of telomere dynamics in both normal hematopoiesis and in malignant hematologic diseases.

  8. Virus como inductores de neoplasias cutáneas Viruses as agents inducing cutaneous neoplasms

    Directory of Open Access Journals (Sweden)

    Francisco Bravo Puccio

    2013-03-01

    Full Text Available El rol oncogénico de los virus en las neoplasias cutáneas es conocido por el hombre desde hace más de un siglo, cuando se atribuía el origen de la verruga vulgar al virus papiloma humano (VPH. En la actualidad, las neoplasias inducidas por virus pueden agruparse en tumores sólidos y procesos linfoproliferativos. Destacan entre los primeros el VPH, del cual ahora conocemos numerosos serotipos, cada uno vinculado a una neoplasia específica, el herpesvirus humano tipo 8 que produce el sarcoma de Kaposi y el poliomavirus vinculado al carcinoma de Merkel. Entre los procesos linfoproliferativos debemos mencionar al virus linfotrópico de células T humanas tipo 1 (HTLV-1 responsable de los linfomas de células T, en los cuales el compromiso cutáneo es inespecífico, con un amplio espectro de presentaciones clínicas y, que por consiguiente, plantean un reto para el diagnóstico diferencial. En este grupo también se encuentra el virus Epstein Barr vinculado a los linfomas nasales de Células NK/T y a los linfomas tipo Hidroa, de reciente descripción. En esta era en la que lo genético y lo molecular priman en las investigaciones en cáncer, no podemos dejar de lado el concepto de neoplasia como resultado de la infección por un agente viral, lo que abre una nueva veta de posibilidades de tratamiento anticanceroso basado en medicamentos antiviralesThe oncogenic role of viruses in cutaneous neoplasms has been known by humankind for more than a century, when the origin of the common wart, or verruca vulgaris, was attributed to the human papilloma virus (HPV. Currently, virus-induced cutaneous neoplasms may be grouped into solid tumors and lymphoproliferative disorders. HPV, from which various serotypes are now known, each being linked to a specific neoplasm, the human herpes virus type 8 producing Kaposi sarcoma, and the Merkel cell polyomavirus, highlight among the first group. Regarding the lymphoproliferative disorders, we should mention the

  9. Genetic variants on chromosome 8q24 and colorectal neoplasia risk: a case-control study in China and a meta-analysis of the published literature.

    Directory of Open Access Journals (Sweden)

    Mian Li

    Full Text Available Previous studies have found that common genetic variants on chromosome 8q24 are associated with the risk of developing colorectal neoplasia. We conducted a hospital-based case-control study, including 435 cases and 788 unrelated controls to investigate the associations between common variants on 8q24 and the risk of colorectal cancer in a Chinese population. We also evaluated the association of rs6983267 with colorectal neoplasia in the published literature via a meta-analysis study. We found that rs6983267 was significantly associated with the risk of colorectal cancer in the Chinese population, with an adjusted odds-ratio (OR for the GT heterozygotes and GG homozygotes of 1.30 (95% CI= 0.98-1.71, P = 0.069 and 1.66 (95% CI = 1.18-2.34, P = 0.004, respectively, compared to the TT homozygotes, with a P-trend value of 0.003. No association was found for the other three loci (rs16901979, rs1447295 and rs7837688. In the meta-analysis of the published genetic association studies, the rs6983267 variant was found to be associated with an increased risk of colorectal neoplasia. The heterozygous GT carriers showed a 20% increased risk of colorectal neoplasia (OR= 1.20, 95% CI= 1.16-1.25; random effects model with a summary OR for homozygous GG carriers of 1.39 (95% CI= 1.32-1.48; random effects model compared to the TT genotype carriers. We found no significant differences between the association of rs6983267 and colorectal cancer and colorectal adenomas. In summary, our study confirms that the variant rs6983267 is a risk factor for colorectal neoplasia in various populations, including the Chinese population.

  10. El uso de fuentes históricas y bases documentales en la formación del profesorado de Educación Infantil y Primaria

    Directory of Open Access Journals (Sweden)

    Juan Antonio Inarejos Muñoz

    2017-01-01

    Full Text Available En este artículo se desarrolla una experiencia metodológica innovadora con alumnos de los grados de Educación Infantil y Educación Primaria centrada en el manejo de fuentes primarias y una base documental en línea. El objetivo de este trabajo persigue familiarizar a los estudiantes con la metodología propia del conocimiento histórico para desarrollar nuevas experiencias educativas donde el trabajo del alumno pasa a un primer plano. A través de la selección de familiares o de personajes aleatorios, se rastrearon en la base documental https://familysearch.org/ los nacimientos, matrimonios y defunciones de sus antepasados. Una vez extraída esta información se elaboraron árboles genealógicos de cada una de las familias escogidas utilizando algunas de las aplicaciones web sugeridas.

  11. Oncogene-induced progression of preneoplastic rat tracheal epithelial cells to neoplasia

    International Nuclear Information System (INIS)

    Thomassen, D.G.; Kelly, G.

    1988-01-01

    N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) induced preneoplastic variants of rat tracheal epithelial (RTE) cells can be neo plastically transformed following transfection with oncogenic DNA. Variants differ with respect to the oncogenes required for neoplastic conversion. Polyma virus DNA transformed each of four variants neo plastically, whereas viral ras DNA only transformed two of four variants. These data demonstrate that preneoplastic variants of RTE cells differ with respect to the changes needed for conversion to neoplastic cells and that the variants tested are either at different stages or on different pathways of progression to neoplasia. (author)

  12. Enfermedad renal crónica en individuos hipertensos ≥60 años atendidos en Atención Primaria

    Directory of Open Access Journals (Sweden)

    Betlem Salvador-González

    2017-07-01

    Conclusiones: Uno de cada 5 hipertensos sin enfermedad cardiovascular ≥60 años en atención primaria presentó disminución moderada del FGe. Además de la edad y el sexo, la albuminuria y la insuficiencia cardiaca fueron los principales factores asociados. A pesar de la mayor exposición a fármacos, el control de la PA fue inferior en ERC.

  13. Condicionantes en la utilización de los servicios de atención primaria: evidencias empíricas e inconsistencias metodológicas

    Directory of Open Access Journals (Sweden)

    Sáez M.

    2003-01-01

    Full Text Available Introducción: En España, el grado y las características de la utilización de los servicios sanitarios de atención primaria está siendo objeto de análisis desde, por lo menos, los años ochenta. Uno de los motivos principales es averiguar hasta qué punto dicha utilización se corresponde con unas necesidades de atención sanitaria. De hecho, se ha establecido como prioridad generalmente aceptada un servicio de salud adecuado para los pacientes que más lo necesitan. Factores condicionantes de la utilización: La evidencia muestra que las características del individuo, sobre todo su estado de salud, son las que se relacionan principalmente con la utilización de servicios de atención primaria. Otras características personales, como el sexo y la edad, podrían actuar como moduladores de la necesidad de atención. Algunas variables familiares y/o culturales, así como las variables relacionadas con el profesional sanitario y otras institucionales, podrían explicar también parte de la variabilidad observada en la utilización de los servicios de atención primaria. Respecto a las variables socioeconómicas, como la renta, se produce una situación paradójica. De forma añadida, existe una evidencia empírica que demuestra que la renta constituye el principal determinante, tanto de la utilización como del gasto sanitario. Cuando se analizan los datos individuales, sin embargo, dicha variable no está relacionada con la utilización de servicios de atención primaria. Inconsistencias metodológicas: La situación es controvertida, con implicaciones no simplemente metodológicas sino, sobre todo, respecto al análisis de la eficiencia en la utilización de los servicios sanitarios de atención primaria. El problema es que, revisando la bibliografía, se pueden apreciar ciertas inconsistencias metodológicas que podrían explicar, al menos en parte, la disparidad de los resultados obtenidos. Entre otras, cabe citar las siguientes

  14. El discurso de los profesionales de atención primaria de la Comunidad de Madrid sobre el trabajo con grupos: sentido, finalidades y ámbitos de intervención

    Directory of Open Access Journals (Sweden)

    Duro Martínez Juan Carlos

    2002-01-01

    Full Text Available Fundamento: La Educación para la salud con grupos es una actividad cada vez más importante en atención primaria. Con el objetivo de contribuir a su desarrollo, esta investigación se plantea conocer los discursos de los profesionales sanitarios sobre las prácticas grupales y específicamente sobre su sentido, finalidades y ámbitos de aplicación. Métodos: Desde una perspectiva cualitativa-estructural se realizaron cuatro grupos de discusión y cuatro entrevistas abiertas con médicos generales, especialistas en Pediatría, en Medicina Familiar y Comunitaria, Enfermería y Trabajo Social, de las Áreas de Atención Primaria de la Comunidad de Madrid. Resultados: Los discursos de los profesionales de atención primaria sobre los grupos se inscriben dentro de las actividades de educación para la salud, siendo ésta una actividad supeditada a la consulta individual. Para hacer grupos los profesionales incluyen argumentos del orden de la jerarquía, eficiencia, eficacia y satisfacción personal. Los principales colectivos objeto del trabajo en grupo son, por este orden, los pacientes crónicos (hipertensos y diabéticos, mujeres (perimenopaúsicas, con malestar general, etc., escolares y profesores, asociaciones de la comunidad y cuidadores de enfermos crónicos. Conclusiones: Los profesionales de atención primaria mayoritariamente consideran el trabajo con grupos como algo marginal cuya finalidad principal sería el ahorro y, subsidiariamente, la Educación para la salud. Se realizan básicamente con pacientes crónicos y mujeres, planteándose el trabajo comunitario en un segundo término.

  15. Disseminated medullary thyroid carcinoma despite early thyroid surgery in the multiple endocrine neoplasia-2A syndrome

    NARCIS (Netherlands)

    van Santen, H. M.; Aronson, D. C.; van Trotsenburg, A. S. P.; ten Kate, F. J. W.; van de Wetering, M. D.; Wiersinga, W. M.; de Vijlder, J. J. M.; Vulsma, T.

    2005-01-01

    A 5 1/2-year-old boy, with a family history of multiple endocrine neoplasia (MEN)-2A syndrome, was evaluated for presence of MEN-2A and medullary thyroid carcinoma (MTC). DNA diagnostics confirmed MEN-2A. Basal (360 ng/L) and pentagastrin stimulated (430 ng/L) calcitonin (CT) levels were slightly

  16. Predictive cytogenetic biomarkers for colorectal neoplasia in medium risk patients.

    Science.gov (United States)

    Ionescu, E M; Nicolaie, T; Ionescu, M A; Becheanu, G; Andrei, F; Diculescu, M; Ciocirlan, M

    2015-01-01

    DNA damage and chromosomal alterations in peripheral lymphocytes parallels DNA mutations in tumor tissues. The aim of our study was to predict the presence of neoplastic colorectal lesions by specific biomarkers in "medium risk" individuals (age 50 to 75, with no personal or family of any colorectal neoplasia). We designed a prospective cohort observational study including patients undergoing diagnostic or opportunistic screening colonoscopy. Specific biomarkers were analyzed for each patient in peripheral lymphocytes - presence of micronuclei (MN), nucleoplasmic bridges (NPB) and the Nuclear Division Index (NDI) by the cytokinesis-blocked micronucleus assay (CBMN). Of 98 patients included, 57 were "medium risk" individuals. MN frequency and NPB presence were not significantly different in patients with neoplastic lesions compared to controls. In "medium risk" individuals, mean NDI was significantly lower for patients with any neoplastic lesions (adenomas and adenocarcinomas, AUROC 0.668, p 00.5), for patients with advanced neoplasia (advanced adenoma and adenocarcinoma, AUROC 0.636 p 0.029) as well as for patients with adenocarcinoma (AUROC 0.650, p 0.048), for each comparison with the rest of the population. For a cut-off of 1.8, in "medium risk" individuals, an NDI inferior to that value may predict any neoplastic lesion with a sensitivity of 97.7%, an advanced neoplastic lesion with a sensitivity of 97% and adenocarcinoma with a sensitivity of 94.4%. NDI score may have a role as a colorectal cancer-screening test in "medium risk" individuals. DNA = deoxyribonucleic acid; CRC = colorectal cancer; EU = European Union; WHO = World Health Organization; FOBT = fecal occult blood test; CBMN = cytokinesis-blocked micronucleus assay; MN = micronuclei; NPB = nucleoplasmic bridges; NDI = Nuclear Division Index; FAP = familial adenomatous polyposis; HNPCC = hereditary non-polypoid colorectal cancer; IBD = inflammatory bowel diseases; ROC = receiver operating

  17. Osteopetrose maligna: transplante de medula óssea Malignant osteopetrosis: bone marrow transplantation

    Directory of Open Access Journals (Sweden)

    Maria L. Borsato

    2008-04-01

    Full Text Available A osteopetrose é uma osteopatia hereditária caracterizada pela deficiência na reabsorção óssea que ocorre por disfunção dos osteoclastos. Com o acúmulo de material osteóide que oblitera o canal medular, ocorre hematopoiese extramedular (hepato-esplenomegalia, obliteração dos forames dos nervos cranianos (cegueira, surdez, paralisias faciais, macrocefalia, protusão da fronte, hipertelorismo, exoftalmo, aumento da pressão intracraniana, retardo na erupção dentária, atraso no crescimento, atraso no desenvolvimento neuropsicomotor, e a morte ocorre precocemente nos primeiros anos de vida. A única alternativa terapêutica curativa é o transplante de medula óssea (TMO de doador HLA idêntico, pois restabelece a hematopoiese e a função monócito-macrófago, com melhora das lesões ósseas e anormalidades hematopoiéticas, embora não reverta as alterações sensoriais já instaladas. Os autores relatam casos de duas crianças portadoras de osteopetrose maligna submetidas ao transplante de medula óssea com sucesso. A primeira encontra-se no dia +1260 do TMO, com melhora evidente da radiologia esquelética, sem progressão das deficiências neurológicas que apresentava, e com biópsia óssea sem sinais de osteopetrose. O segundo paciente encontra-se no dia + 700, com sinais de reabsorção óssea e sem progressão dos danos neurológicos. Os autores chamam a atenção para a necessidade de diagnóstico precoce da osteopetrose e o rápido encaminhamento para o transplante de medula óssea antes da instalação de seqüelas neurológicas definitivas.Osteopetrosis is an inherited disorder characterized by the inability to reabsorb and remodel bone due to osteoclast dysfunction. The encroachment by bone and mineralized cartilage of the medullary cavities leads to extramedullary hematopoiesis (hepatosplenomegaly and cranial-nerve foramina leads to blindness, auditory nerve damage, and occulomotor and facial nerve palsies. Defective

  18. Estado de salud en el adulto mayor en atención primaria a partir de una valoración geriátrica integral

    Directory of Open Access Journals (Sweden)

    Roxana Gisela Cervantes Becerra

    2015-06-01

    Conclusión: El estado de salud en el adulto mayor que acude a atención primaria se caracteriza por pacientes independientes con diferente grado de alteraciones en la dimensión médica, bajo grado de alteración mental y recursos sociales medianamente deteriorados.

  19. Low accuracy of tumor markers for diagnosing pancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1 patients

    NARCIS (Netherlands)

    de Laat, Joanne M.; Pieterman, Carolina R. C.; Weijmans, Maaike; Hermus, Ad R.; Dekkers, Olaf M.; de Herder, Wouter W.; van der Horst-Schrivers, Anouk N. A.; Drent, Madeleine L.; Bisschop, Peter H.; Havekes, Bas; Vriens, Menno R.; Valk, Gerlof D.

    2013-01-01

    Context: The assessment of tumor markers for diagnosing pancreatic neuroendocrine tumors (pNET) in multiple endocrine neoplasia type 1 (MEN1) patients is advised in the current guidelines but has never been validated for this purpose. Objective: The objective of the study was to assess the

  20. Low Accuracy of Tumor Markers for Diagnosing Pancreatic Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1 Patients

    NARCIS (Netherlands)

    de Laat, Joanne M.; Pieterman, Carolina R. C.; Weijmans, Maaike; Hermus, Ad R.; Dekkers, Olaf M.; de Herder, Wouter W.; van der Horst-Schrivers, Anouk N. A.; Drent, Madeleine L.; Bisschop, Peter H.; Havekes, Bas; Vriens, Menno R.; Valk, Gerlof D.

    2013-01-01

    Context: The assessment of tumor markers for diagnosing pancreatic neuroendocrine tumors (pNET) in multiple endocrine neoplasia type 1 (MEN1) patients is advised in the current guidelines but has never been validated for this purpose. Objective: The objective of the study was to assess the