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Sample records for ncicb gforge uml

  1. UML 2 Semantics and Applications

    CERN Document Server

    Lano, Kevin

    2009-01-01

    A coherent and integrated account of the leading UML 2 semantics work and the practical applications of UML semantics development With contributions from leading experts in the field, the book begins with an introduction to UML and goes on to offer in-depth and up-to-date coverage of: The role of semantics Considerations and rationale for a UML system model Definition of the UML system model UML descriptive semantics Axiomatic semantics of UML class diagrams The object constraint language Axiomatic semantics of state machines A coalgebraic semantic framework for reasoning about interaction des

  2. Optimizing UML Class Diagrams

    Directory of Open Access Journals (Sweden)

    Sergievskiy Maxim

    2018-01-01

    Full Text Available Most of object-oriented development technologies rely on the use of the universal modeling language UML; class diagrams play a very important role in the design process play, used to build a software system model. Modern CASE tools, which are the basic tools for object-oriented development, can’t be used to optimize UML diagrams. In this manuscript we will explain how, based on the use of design patterns and anti-patterns, class diagrams could be verified and optimized. Certain transformations can be carried out automatically; in other cases, potential inefficiencies will be indicated and recommendations given. This study also discusses additional CASE tools for validating and optimizing of UML class diagrams. For this purpose, a plugin has been developed that analyzes an XMI file containing a description of class diagrams.

  3. UML 2.0 Pocket Reference UML Syntax and Usage

    CERN Document Server

    Pilone, Dan

    2006-01-01

    Globe-trotting travelers have long resorted to handy, pocket-size dictionaries as an aid to communicating across the language barrier. Dan Pilone's UML 2.0 Pocket Reference is just such an aid for on-the-go developers who need to converse in the Unified Modeling Language (UML). Use this book to decipher the many UML diagrams you'll encounter on the path to delivering a modern software system. Updated to cover the very latest in UML, you'll find coverage of the following UML 2.0 diagram types: Class diagramsComponent diagrams*Sequence diagrams*Communication diagrams*Timing diagrams*Interactio

  4. Learning UML 2.0

    CERN Document Server

    Miles, Russ

    2006-01-01

    Engaging and accessible, this book shows you how to use UML to craft and communicate your project's design. Russ Miles and Kim Hamilton have written a pragmatic introduction to UML based on hard-earned practice, not theory. Regardless of the software process or methodology you use, this book is the one source you need to get up and running with UML 2.0

  5. Formal Verification of UML Profil

    DEFF Research Database (Denmark)

    Bhutto, Arifa; Hussain, Dil Muhammad Akbar

    2011-01-01

    The Unified Modeling Language (UML) is based on the Model Driven Development (MDD) approach which capturing the system functionality using the platform-independent model (PMI) and appropriate domain-specific languages. In UML base system notations, structural view is model by the class, components...

  6. Unified Medical Language System (UMLS)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The UMLS integrates and distributes key terminology, classification and coding standards, and associated resources to promote creation of more effective and...

  7. UML 2 Certification Guide Fundamental & Intermediate Exams

    CERN Document Server

    Weilkiens, Tim

    2006-01-01

    The popular Unified Modeling Language (UML) is both a language and notation developed by the Object Management Group (OMG) used to design and create specifications for software systems. With the recent release of version 2.0 UML, the OMG has started the OMG-Certified UML Professional Program to provide an objective measure of UML knowledge. As a certified UML professional a developer has an important credential to present to employers and clients. Certification also benefits companies looking for skilled UML practitioners by giving them a basis for making hiring and promotion decisions.UML 2 C

  8. UML in business process modeling

    Directory of Open Access Journals (Sweden)

    Bartosz Marcinkowski

    2013-03-01

    Full Text Available Selection and proper application of business process modeling methods and techniques have a significant impact on organizational improvement capabilities as well as proper understanding of functionality of information systems that shall support activity of the organization. A number of business process modeling notations were popularized in practice in recent decades. Most significant of the notations include Business Process Modeling Notation (OMG BPMN and several Unified Modeling Language (OMG UML extensions. In this paper, the assessment whether one of the most flexible and strictly standardized contemporary business process modeling notations, i.e. Rational UML Profile for Business Modeling, enable business analysts to prepare business models that are all-embracing and understandable by all the stakeholders. After the introduction, methodology of research is discussed. Section 2 presents selected case study results. The paper is concluded with a summary.

  9. 3rd International Workshop on Critical Systems Development with UML

    OpenAIRE

    Jan Jürjens; Eduardo B. Fernandez; Robert France; Bernhard Rumpe

    2017-01-01

    Topics of the Workshop include: --- Applications of UML to real-time systems security-critical systems dependable / safety-critical systems performance-critical systems embedded systems hybrid systems reactive systems --- Extensions of UML (UML-RT, UMLsec, Automotive UML, Embedded UML, ...) and new developments (UML 2.0, MDA) --- Modeling, synthesis, model transformation, code generation, testing, validation, and verification of critical systems using UML --- Aspect-oriented or Component-base...

  10. Preface to FP-UML 2009

    Science.gov (United States)

    Trujillo, Juan; Kim, Dae-Kyoo

    The Unified Modeling Language (UML) has been widely accepted as the standard object-oriented (OO) modeling language for modeling various aspects of software and information systems. The UML is an extensible language, in the sense that it provides mechanisms to introduce new elements for specific domains if necessary, such as web applications, database applications, business modeling, software development processes, data warehouses. Furthermore, the latest version of UML 2.0 got even bigger and more complicated with more diagrams for some good reasons. Although UML provides different diagrams for modeling different aspects of a software system, not all of them need to be applied in most cases. Therefore, heuristics, design guidelines, lessons learned from experiences are extremely important for the effective use of UML 2.0 and to avoid unnecessary complication. Also, approaches are needed to better manage UML 2.0 and its extensions so they do not become too complex too manage in the end.

  11. From UML Specification into FPGA Implementation

    Directory of Open Access Journals (Sweden)

    Grzegorz Bazydlo

    2014-01-01

    Full Text Available In the paper a method of using the Unified Modeling Language for specification of digital systems, especially logic controllers, is presented. The proposed method is based mainly on the UML state machine diagrams and uses Hierarchical Concurrent Finite State Machines (HCFSMs as a temporary model. The paper shows a way to transform the UML diagrams, expressed in XML language, to the form that is acceptable by reconfigurable FPGAs (Field Programmable Gate Arrays. The UML specification is used to generate an effective program in Hardware Description Languages (HDLs, especially Verilog.

  12. minimUML: A Minimalist Approach to UML Diagramming for Early Computer Science Education

    Science.gov (United States)

    Turner, Scott A.; Perez-Quinones, Manuel A.; Edwards, Stephen H.

    2005-01-01

    In introductory computer science courses, the Unified Modeling Language (UML) is commonly used to teach basic object-oriented design. However, there appears to be a lack of suitable software to support this task. Many of the available programs that support UML focus on developing code and not on enhancing learning. Programs designed for…

  13. Model-Driven Theme/UML

    Science.gov (United States)

    Carton, Andrew; Driver, Cormac; Jackson, Andrew; Clarke, Siobhán

    Theme/UML is an existing approach to aspect-oriented modelling that supports the modularisation and composition of concerns, including crosscutting ones, in design. To date, its lack of integration with model-driven engineering (MDE) techniques has limited its benefits across the development lifecycle. Here, we describe our work on facilitating the use of Theme/UML as part of an MDE process. We have developed a transformation tool that adopts model-driven architecture (MDA) standards. It defines a concern composition mechanism, implemented as a model transformation, to support the enhanced modularisation features of Theme/UML. We evaluate our approach by applying it to the development of mobile, context-aware applications-an application area characterised by many non-functional requirements that manifest themselves as crosscutting concerns.

  14. Executable UML Modeling For Automotive Embedded Systems

    International Nuclear Information System (INIS)

    Gerard, Sebastien

    2000-01-01

    Engineers are more and more faced to the hard problem of sophisticated real-time System whereas time to market becomes always smaller. Object oriented modeling supported by UML standard brings effective solutions to such problems. However the possibility to specify real-time aspects of an application are not yet fully satisfactory Indeed, existing industrial proposals supply good answers to concurrency specification problem but they are yet limited regarding to real-time quantitative properties specification of an application. This work aims to construct a complete and consistent UML methodology based on a profile dedicated to automotive embedded Systems modeling and prototyping. This profile contains ail needed extensions to express easily the real-time quantitative properties of an application. Moreover, thanks to the formalization of UML protocol state machines, real-time concepts have been well-integrated in the object oriented paradigm. The main result of this deep integration is that a user is now able to model real-time Systems through the classical object oriented view i.e. without needing any specific knowing in real-time area. In order to answer to an industrial requirement, Systems prototyping (key point for car industry) the ACCORD/UML approach allows also to build executable models of an application. For that purpose, the method supplies a set of rules allow.ng to remove UML ambiguous semantics points, to complete semantics variation points and then to obtain a complete and coherent global model of an application being executable. The work of UML extension and its using formalization realized all along this thesis supplied also a complete and non-ambiguous modeling framework for automotive electronics Systems development. This is also a base particularly well-suited to tackle other facets of the Systems development as automatic and optimized code generation, validation, simulation or tests. (author) [fr

  15. UML for systems engineering watching the wheels

    CERN Document Server

    Holt, Jon

    2005-01-01

    Up until a few years ago there were over 150 different modelling languages available to software developers. This vast array of choice however, only served to severely hinder effective communication. Therefore, to combat this, every methodologist and many companies agreed to speak the same language, hence the birth of the unified modelling language (UML). The UML offers a means to communicate complex information in a simple way using visual modelling; i.e. drawing diagrams to create a model of a system. This fully revised edition, based on a training course given by the author, coincides with

  16. UML Semantics FAQ: Dynamic Behaviour and Concurrency

    NARCIS (Netherlands)

    Wieringa, Roelf J.; Demeyer, Serge; Astesiano, Egidio; Reggio, Gianna; Le Guennec, Alain; Hussman, Heinrich; van den Berg, Klaas; van den Broek, P.M.

    This paper reports the results of a workshop held at ECOOP'99. The workshop was set up to find answers to questions fundamental to the definition of a semantics for the Unified Modelling Language. Questions examined the meaning of the term semantics in the context of UML; approaches to defining the

  17. Efficient Representation of Timed UML 2 Interactions

    DEFF Research Database (Denmark)

    Knapp, Alexander; Störrle, Harald

    2014-01-01

    UML 2 interactions describe system behavior over time in a declarative way. The standard approach to defining their formal semantics enumerates traces of events; other representation formats, like Büchi automata or prime event structures, have been suggested, too. We describe another, more succin...

  18. MODELING WORK OF SORTING STATION USING UML

    Directory of Open Access Journals (Sweden)

    O. V. Gorbova

    2014-12-01

    Full Text Available Purpose. The purpose of this paper is the construction of methods and models for the graphical representation process of sorting station, using the unified modeling language (UML. Methodology. Methods of graph theory, finite automata and the representation theory of queuing systems were used as the methods of investigation. A graphical representation of the process was implemented with using the Unified Modeling Language UML. The sorting station process representation is implemented as a state diagram and actions through a set of IBM Rational Rose. Graphs can show parallel operation of sorting station, the parallel existence and influence of objects process and the transition from one state to another. The IBM Rational Rose complex allows developing a diagram of work sequence of varying degrees of detailing. Findings. The study has developed a graphical representation method of the process of sorting station of different kind of complexity. All graphical representations are made using the UML. They are represented as a directed graph with the states. It is clear enough in the study of the subject area. Applying the methodology of the representation process, it allows becoming friendly with the work of any automation object very fast, and exploring the process during algorithms construction of sorting stations and other railway facilities. This model is implemented with using the Unified Modeling Language (UML using a combination of IBM Rational Rose. Originality. The representation process of sorting station was developed by means of the Unified Modeling Language (UML use. Methodology of representation process allows creating the directed graphs based on the order of execution of the works chain, objects and performers of these works. The UML allows visualizing, specifying, constructing and documenting, formalizing the representation process of sorting station and developing sequence diagrams of works of varying degrees of detail. Practical

  19. BGen: A UML Behavior Network Generator Tool

    Science.gov (United States)

    Huntsberger, Terry; Reder, Leonard J.; Balian, Harry

    2010-01-01

    BGen software was designed for autogeneration of code based on a graphical representation of a behavior network used for controlling automatic vehicles. A common format used for describing a behavior network, such as that used in the JPL-developed behavior-based control system, CARACaS ["Control Architecture for Robotic Agent Command and Sensing" (NPO-43635), NASA Tech Briefs, Vol. 32, No. 10 (October 2008), page 40] includes a graph with sensory inputs flowing through the behaviors in order to generate the signals for the actuators that drive and steer the vehicle. A computer program to translate Unified Modeling Language (UML) Freeform Implementation Diagrams into a legacy C implementation of Behavior Network has been developed in order to simplify the development of C-code for behavior-based control systems. UML is a popular standard developed by the Object Management Group (OMG) to model software architectures graphically. The C implementation of a Behavior Network is functioning as a decision tree.

  20. Simplifications of rational matrices by using UML

    OpenAIRE

    Tasić, Milan B.; Stanimirović, Ivan P.

    2013-01-01

    The simplification process on rational matrices consists of simplifying each entry represented by a rational function. We follow the classic approach of dividing the numerator and denominator polynomials by their common GCD polynomial, and provide the activity diagram in UML for this process. A rational matrix representation as the quotient of a polynomial matrix and a polynomial is also discussed here and illustrated via activity diagrams. Also, a class diagram giving the links between the c...

  1. UML: Un lenguaje de modelo de objetos

    Directory of Open Access Journals (Sweden)

    Luis Ignacio Lizcano-Bueno

    2002-01-01

    Full Text Available A Unified Modeling Language (UML: Unified Modeling Language is a tool that allows object-oriented modeling across a wide graphic vocabulary focused on conceptual and physical representation of software systems software. It is now a standard adopted by the development group orbjetos (OMG: Object Management Group.   This paper presents an introduction to this language, the different components that form and briefly explain their functions are shown.

  2. Auditing the Assignments of Top-Level Semantic Types in the UMLS Semantic Network to UMLS Concepts.

    Science.gov (United States)

    He, Zhe; Perl, Yehoshua; Elhanan, Gai; Chen, Yan; Geller, James; Bian, Jiang

    2017-11-01

    The Unified Medical Language System (UMLS) is an important terminological system. By the policy of its curators, each concept of the UMLS should be assigned the most specific Semantic Types (STs) in the UMLS Semantic Network (SN). Hence, the Semantic Types of most UMLS concepts are assigned at or near the bottom (leaves) of the UMLS Semantic Network. While most ST assignments are correct, some errors do occur. Therefore, Quality Assurance efforts of UMLS curators for ST assignments should concentrate on automatically detected sets of UMLS concepts with higher error rates than random sets. In this paper, we investigate the assignments of top-level semantic types in the UMLS semantic network to concepts, identify potential erroneous assignments, define four categories of errors, and thus provide assistance to curators of the UMLS to avoid these assignments errors. Human experts analyzed samples of concepts assigned 10 of the top-level semantic types and categorized the erroneous ST assignments into these four logical categories. Two thirds of the concepts assigned these 10 top-level semantic types are erroneous. Our results demonstrate that reviewing top-level semantic type assignments to concepts provides an effective way for UMLS quality assurance, comparing to reviewing a random selection of semantic type assignments.

  3. Supporting several levels of restriction in the UML

    DEFF Research Database (Denmark)

    Hansen, Klaus Marius; Damm, Christian Heide; Thomsen, Michael

    2000-01-01

    The emergence of the Unified Modeling Language (UML) has provided software developers with an effective and efficient shared language. However, UML is often too restrictive in initial, informal, and creative modelling, and it is in some cases not restrictive enough, e.g., for code generation. Bas....... This approach potentially increases the usability of the UML, and thus ultimately leads to greater quality and adoption of UML models.......The emergence of the Unified Modeling Language (UML) has provided software developers with an effective and efficient shared language. However, UML is often too restrictive in initial, informal, and creative modelling, and it is in some cases not restrictive enough, e.g., for code generation. Based...

  4. TGGs for Transforming UML to CSP

    DEFF Research Database (Denmark)

    Greenyer, Joel; Kindler, Ekkart; Rieke, Jan

    Contest. The second transformation problem, a transformation from UML activity diagrams to CSP processes, i.e. a transformation between two models, is a typical application for Triple Graph Grammars (TGGs). We present our contributed solution, presenting the TGG rules and the implementation of our TGG...... interpreter. Moreover, we point out the advantages of our soulution as well as some restrictions of the current implementation. This paper will only briefly state the transformation problem and focus on our TGG approach and the discussion of the rules....

  5. Aspect-oriented security hardening of UML design models

    CERN Document Server

    Mouheb, Djedjiga; Pourzandi, Makan; Wang, Lingyu; Nouh, Mariam; Ziarati, Raha; Alhadidi, Dima; Talhi, Chamseddine; Lima, Vitor

    2015-01-01

    This book comprehensively presents a novel approach to the systematic security hardening of software design models expressed in the standard UML language. It combines model-driven engineering and the aspect-oriented paradigm to integrate security practices into the early phases of the software development process. To this end, a UML profile has been developed for the specification of security hardening aspects on UML diagrams. In addition, a weaving framework, with the underlying theoretical foundations, has been designed for the systematic injection of security aspects into UML models. The

  6. Rewriting and suppressing UMLS terms for improved biomedical term identification

    NARCIS (Netherlands)

    K.M. Hettne (Kristina); E.M. van Mulligen (Erik); M.J. Schuemie (Martijn); R.J.A. Schijvenaars (Bob); J.A. Kors (Jan)

    2010-01-01

    textabstractBackground: Identification of terms is essential for biomedical text mining. We concentrate here on the use of vocabularies for term identification, specifically the Unified Medical Language System (UMLS). To make the UMLS more suitable for biomedical text mining we implemented and

  7. The Development Methodology of the UML Electronic Guide

    Directory of Open Access Journals (Sweden)

    N.A. Magariu

    2006-09-01

    Full Text Available A technological model for realization of the electronic guide to UML language is considered. This model includes description of peculiarities of using the special graphic editor for constructing the UML diagrams, XML vocabularies (XMI, DocBook, SVG, XSLT for representing the text and diagrams and JavaScript code for constructing the tests.

  8. Comprehensive Aspectual UML Approach to Support AspectJ

    Directory of Open Access Journals (Sweden)

    Aws Magableh

    2014-01-01

    Full Text Available Unified Modeling Language is the most popular and widely used Object-Oriented modelling language in the IT industry. This study focuses on investigating the ability to expand UML to some extent to model crosscutting concerns (Aspects to support AspectJ. Through a comprehensive literature review, we identify and extensively examine all the available Aspect-Oriented UML modelling approaches and find that the existing Aspect-Oriented Design Modelling approaches using UML cannot be considered to provide a framework for a comprehensive Aspectual UML modelling approach and also that there is a lack of adequate Aspect-Oriented tool support. This study also proposes a set of Aspectual UML semantic rules and attempts to generate AspectJ pseudocode from UML diagrams. The proposed Aspectual UML modelling approach is formally evaluated using a focus group to test six hypotheses regarding performance; a “good design” criteria-based evaluation to assess the quality of the design; and an AspectJ-based evaluation as a reference measurement-based evaluation. The results of the focus group evaluation confirm all the hypotheses put forward regarding the proposed approach. The proposed approach provides a comprehensive set of Aspectual UML structural and behavioral diagrams, which are designed and implemented based on a comprehensive and detailed set of AspectJ programming constructs.

  9. Comprehensive Aspectual UML approach to support AspectJ.

    Science.gov (United States)

    Magableh, Aws; Shukur, Zarina; Ali, Noorazean Mohd

    2014-01-01

    Unified Modeling Language is the most popular and widely used Object-Oriented modelling language in the IT industry. This study focuses on investigating the ability to expand UML to some extent to model crosscutting concerns (Aspects) to support AspectJ. Through a comprehensive literature review, we identify and extensively examine all the available Aspect-Oriented UML modelling approaches and find that the existing Aspect-Oriented Design Modelling approaches using UML cannot be considered to provide a framework for a comprehensive Aspectual UML modelling approach and also that there is a lack of adequate Aspect-Oriented tool support. This study also proposes a set of Aspectual UML semantic rules and attempts to generate AspectJ pseudocode from UML diagrams. The proposed Aspectual UML modelling approach is formally evaluated using a focus group to test six hypotheses regarding performance; a "good design" criteria-based evaluation to assess the quality of the design; and an AspectJ-based evaluation as a reference measurement-based evaluation. The results of the focus group evaluation confirm all the hypotheses put forward regarding the proposed approach. The proposed approach provides a comprehensive set of Aspectual UML structural and behavioral diagrams, which are designed and implemented based on a comprehensive and detailed set of AspectJ programming constructs.

  10. Analysis of Sequence Diagram Layout in Advanced UML Modelling Tools

    Directory of Open Access Journals (Sweden)

    Ņikiforova Oksana

    2016-05-01

    Full Text Available System modelling using Unified Modelling Language (UML is the task that should be solved for software development. The more complex software becomes the higher requirements are stated to demonstrate the system to be developed, especially in its dynamic aspect, which in UML is offered by a sequence diagram. To solve this task, the main attention is devoted to the graphical presentation of the system, where diagram layout plays the central role in information perception. The UML sequence diagram due to its specific structure is selected for a deeper analysis on the elements’ layout. The authors research represents the abilities of modern UML modelling tools to offer automatic layout of the UML sequence diagram and analyse them according to criteria required for the diagram perception.

  11. Towards Clone Detection in UML Domain Models

    DEFF Research Database (Denmark)

    Störrle, Harald

    2013-01-01

    Code clones (i.e., duplicate fragments of code) have been studied for long, and there is strong evidence that they are a major source of software faults. Anecdotal evidence suggests that this phenomenon occurs similarly in models, suggesting that model clones are as detrimental to model quality...... as they are to code quality. However, programming language code and visual models have significant differences that make it difficult to directly transfer notions and algorithms developed in the code clone arena to model clones. In this article, we develop and propose a definition of the notion of “model clone” based...... we believe that our approach advances the state of the art significantly, it is restricted to UML models, its results leave room for improvements, and there is no validation by field studies....

  12. Specification of real-time automation systems with HybridUML; Spezifikation von Echtzeit-Automatisierungssystemen mit HybridUML

    Energy Technology Data Exchange (ETDEWEB)

    Berkenkoetter, K.; Bisanz, S.; Hannemann, U.; Peleska, J. [Univ. Bremen (Germany)

    2004-07-01

    Complex automation systems require specification formalisms supporting the description of real-time requirements with respect to both discrete and time-continuous observables. For this purpose, the authors have designed the HybridUML specification language. Discrete events, communication, and variable assignments are specified by state machines, timers, and invariant conditions. The time-continuous aspects of system behaviour are described by associating differential equations or time-dependent algebraic conditions with system states. The complexity of large systems is controlled by decomposing the specification into parallel components and hierarchical state machines. Instead of inventing a new language syntax, HybridUML is represented as a profile of the Unified Modeling Language UML 2.0. This allows to re-use the syntactic framework of well-accepted graphical UML constructs and development support provided by various UML case tools. The profile is associated with a precise language semantics linking unambiguous meaning to all HybridUML specifications. As a consequence, HybridUML specifications can be compiled into executable code which is suitable for execution in hard realtime on multi-processor computers. This serves both for the development of automation systems and for specification-based testing in real-time. This paper contains an introduction to HybridUML which is illustrated by an example from the field of automated train control. (orig.)

  13. Connecting UML and VDM++ with Open Tool Support

    DEFF Research Database (Denmark)

    Lausdahl, Kenneth; Listrup, Hans Kristian; Larsen, Peter Gorm

    2009-01-01

    Most formal method notations are text based, while tools used in industry often use graphical notations, such as UML. This paper demonstrates how the power of both approaches can be combined by providing the automatic translation of VDM++ models to and from UML. The translation is implemented as ...... as a plugin for the popular Eclipse development environment by the open-source Overture initiative. Both UML class diagrams and sequence diagrams can be translated, the latter enabling the novel ability to link with the combinatorial test facility of Overture....

  14. HRT-UML: a design method for hard real-time systems based on the UML notation

    Science.gov (United States)

    D'Alessandro, Massimo; Mazzini, Silvia; di Natale, Marco; Lipari, Giuseppe

    2002-07-01

    The Hard Real-Time-Unified Modelling Language (HRT-UML) method aims at providing a comprehensive solution to the modeling of Hard Real Time systems. The experience shows that the design of Hard Real-Time systems needs methodologies suitable for the modeling and analysis of aspects related to time, schedulability and performance. In the context of the European Aerospace community a reference method for design is Hierarchical Object Oriented Design (HOOD) and in particular its extension for the modeling of hard real time systems, Hard Real-Time-Hierarchical Object Oriented Design (HRT-HOOD), recommended by the European Space Agency (ESA) for the development of on-board systems. On the other hand in recent years the Unified Modelling Language (UML) has been gaining a very large acceptance in a wide range of domains, all over the world, becoming a de-facto international standard. Tool vendors are very active in this potentially big market. In the Aerospace domain the common opinion is that UML, as a general notation, is not suitable for Hard Real Time systems, even if its importance is recognized as a standard and as a technological trend in the near future. These considerations suggest the possibility of replacing the HRT-HOOD method with a customized version of UML, that incorporates the advantages of both standards and complements the weak points. This approach has the clear advantage of making HRT-HOOD converge on a more powerful and expressive modeling notation. The paper identifies a mapping of the HRT-HOOD semantics into the UML one, and proposes a UML extension profile, that we call HRT-UML, based on the UML standard extension mechanisms, to fully represent HRT-HOOD design concepts. Finally it discusses the relationships between our profile and the UML profile for schedulability, performance and time, adopted by OMG in November 2001.

  15. Sophia: A Expedient UMLS Concept Extraction Annotator.

    Science.gov (United States)

    Divita, Guy; Zeng, Qing T; Gundlapalli, Adi V; Duvall, Scott; Nebeker, Jonathan; Samore, Matthew H

    2014-01-01

    An opportunity exists for meaningful concept extraction and indexing from large corpora of clinical notes in the Veterans Affairs (VA) electronic medical record. Currently available tools such as MetaMap, cTAKES and HITex do not scale up to address this big data need. Sophia, a rapid UMLS concept extraction annotator was developed to fulfill a mandate and address extraction where high throughput is needed while preserving performance. We report on the development, testing and benchmarking of Sophia against MetaMap and cTAKEs. Sophia demonstrated improved performance on recall as compared to cTAKES and MetaMap (0.71 vs 0.66 and 0.38). The overall f-score was similar to cTAKES and an improvement over MetaMap (0.53 vs 0.57 and 0.43). With regard to speed of processing records, we noted Sophia to be several fold faster than cTAKES and the scaled-out MetaMap service. Sophia offers a viable alternative for high-throughput information extraction tasks.

  16. An Infrastructure for UML-Based Code Generation Tools

    Science.gov (United States)

    Wehrmeister, Marco A.; Freitas, Edison P.; Pereira, Carlos E.

    The use of Model-Driven Engineering (MDE) techniques in the domain of distributed embedded real-time systems are gain importance in order to cope with the increasing design complexity of such systems. This paper discusses an infrastructure created to build GenERTiCA, a flexible tool that supports a MDE approach, which uses aspect-oriented concepts to handle non-functional requirements from embedded and real-time systems domain. GenERTiCA generates source code from UML models, and also performs weaving of aspects, which have been specified within the UML model. Additionally, this paper discusses the Distributed Embedded Real-Time Compact Specification (DERCS), a PIM created to support UML-based code generation tools. Some heuristics to transform UML models into DERCS, which have been implemented in GenERTiCA, are also discussed.

  17. Tracing the Rationale Behind UML Model Change Through Argumentation

    Science.gov (United States)

    Jureta, Ivan J.; Faulkner, Stéphane

    Neglecting traceability—i.e., the ability to describe and follow the life of a requirement—is known to entail misunderstanding and miscommunication, leading to the engineering of poor quality systems. Following the simple principles that (a) changes to UML model instances ought be justified to the stakeholders, (b) justification should proceed in a structured manner to ensure rigor in discussions, critique, and revisions of model instances, and (c) the concept of argument instantiated in a justification process ought to be well defined and understood, the present paper introduces the UML Traceability through Argumentation Method (UML-TAM) to enable the traceability of design rationale in UML while allowing the appropriateness of model changes to be checked by analysis of the structure of the arguments provided to justify such changes.

  18. Semi-Supervised Learning to Identify UMLS Semantic Relations.

    Science.gov (United States)

    Luo, Yuan; Uzuner, Ozlem

    2014-01-01

    The UMLS Semantic Network is constructed by experts and requires periodic expert review to update. We propose and implement a semi-supervised approach for automatically identifying UMLS semantic relations from narrative text in PubMed. Our method analyzes biomedical narrative text to collect semantic entity pairs, and extracts multiple semantic, syntactic and orthographic features for the collected pairs. We experiment with seeded k-means clustering with various distance metrics. We create and annotate a ground truth corpus according to the top two levels of the UMLS semantic relation hierarchy. We evaluate our system on this corpus and characterize the learning curves of different clustering configuration. Using KL divergence consistently performs the best on the held-out test data. With full seeding, we obtain macro-averaged F-measures above 70% for clustering the top level UMLS relations (2-way), and above 50% for clustering the second level relations (7-way).

  19. The Use of UML for Software Requirements Expression and Management

    Science.gov (United States)

    Murray, Alex; Clark, Ken

    2015-01-01

    It is common practice to write English-language "shall" statements to embody detailed software requirements in aerospace software applications. This paper explores the use of the UML language as a replacement for the English language for this purpose. Among the advantages offered by the Unified Modeling Language (UML) is a high degree of clarity and precision in the expression of domain concepts as well as architecture and design. Can this quality of UML be exploited for the definition of software requirements? While expressing logical behavior, interface characteristics, timeliness constraints, and other constraints on software using UML is commonly done and relatively straight-forward, achieving the additional aspects of the expression and management of software requirements that stakeholders expect, especially traceability, is far less so. These other characteristics, concerned with auditing and quality control, include the ability to trace a requirement to a parent requirement (which may well be an English "shall" statement), to trace a requirement to verification activities or scenarios which verify that requirement, and to trace a requirement to elements of the software design which implement that requirement. UML Use Cases, designed for capturing requirements, have not always been satisfactory. Some applications of them simply use the Use Case model element as a repository for English requirement statements. Other applications of Use Cases, in which Use Cases are incorporated into behavioral diagrams that successfully communicate the behaviors and constraints required of the software, do indeed take advantage of UML's clarity, but not in ways that support the traceability features mentioned above. Our approach uses the Stereotype construct of UML to precisely identify elements of UML constructs, especially behaviors such as State Machines and Activities, as requirements, and also to achieve the necessary mapping capabilities. We describe this approach in the

  20. Transformation of UML Behavioral Diagrams to Support Software Model Checking

    Directory of Open Access Journals (Sweden)

    Luciana Brasil Rebelo dos Santos

    2014-04-01

    Full Text Available Unified Modeling Language (UML is currently accepted as the standard for modeling (object-oriented software, and its use is increasing in the aerospace industry. Verification and Validation of complex software developed according to UML is not trivial due to complexity of the software itself, and the several different UML models/diagrams that can be used to model behavior and structure of the software. This paper presents an approach to transform up to three different UML behavioral diagrams (sequence, behavioral state machines, and activity into a single Transition System to support Model Checking of software developed in accordance with UML. In our approach, properties are formalized based on use case descriptions. The transformation is done for the NuSMV model checker, but we see the possibility in using other model checkers, such as SPIN. The main contribution of our work is the transformation of a non-formal language (UML to a formal language (language of the NuSMV model checker towards a greater adoption in practice of formal methods in software development.

  1. Extracting UML Class Diagrams from Object-Oriented Fortran: ForUML

    Directory of Open Access Journals (Sweden)

    Aziz Nanthaamornphong

    2015-01-01

    Full Text Available Many scientists who implement computational science and engineering software have adopted the object-oriented (OO Fortran paradigm. One of the challenges faced by OO Fortran developers is the inability to obtain high level software design descriptions of existing applications. Knowledge of the overall software design is not only valuable in the absence of documentation, it can also serve to assist developers with accomplishing different tasks during the software development process, especially maintenance and refactoring. The software engineering community commonly uses reverse engineering techniques to deal with this challenge. A number of reverse engineering-based tools have been proposed, but few of them can be applied to OO Fortran applications. In this paper, we propose a software tool to extract unified modeling language (UML class diagrams from Fortran code. The UML class diagram facilitates the developers' ability to examine the entities and their relationships in the software system. The extracted diagrams enhance software maintenance and evolution. The experiments carried out to evaluate the proposed tool show its accuracy and a few of the limitations.

  2. Construction of UML class diagram with Model-Driven Development

    Directory of Open Access Journals (Sweden)

    Tomasz Górski

    2016-03-01

    Full Text Available Model transformations play a key role in software development projects based on Model--Driven Development (MDD principles. Transformations allow for automation of repetitive and well-defined steps, thus shortening design time and reducing a number of errors. In the object-oriented approach, the key elements are use cases. They are described, modelled and later designed until executable application code is obtained. The aim of the paper is to present transformation of a model-to-model type, Communication-2-Class, which automates construction of Unified Modelling Language (UML class diagram in the context of the analysis/design model. An UML class diagram is created based on UML communication diagram within use case realization. As a result, a class diagram shows all of the classes involved in the use case realization and the relationships among them. The plug-in which implements Communication-2-Class transformation was implemented in the IBM Rational Software Architect. The article presents the tests results of developed plug-in, which realizes Communication-2-Class transformation, showing capabilities of shortening use case realization’s design time.[b]Keywords[/b]: Model-Driven Development, transformations, Unified Modelling Language, analysis/design model, UML class diagram, UML communication diagram

  3. Vehicle System Management Modeling in UML for Ares I

    Science.gov (United States)

    Pearson, Newton W.; Biehn, Bradley A.; Curry, Tristan D.; Martinez, Mario R.

    2011-01-01

    The Spacecraft & Vehicle Systems Department of Marshall Space Flight Center is responsible for modeling the Vehicle System Management for the Ares I vehicle which was a part of the now canceled Constellation Program. An approach to generating the requirements for the Vehicle System Management was to use the Unified Modeling Language technique to build and test a model that would fulfill the Vehicle System Management requirements. UML has been used on past projects (flight software) in the design phase of the effort but this was the first attempt to use the UML technique from a top down requirements perspective.

  4. For-LySa: UML for Authentication Analysis

    DEFF Research Database (Denmark)

    Buchholtz, Mikael; Montangero, Carlo; Perrone, Lara

    2005-01-01

    The DEGAS project aims at enriching standard UML-centred development environments in such a way that the developers of global applications can exploit automated formal analyses with minimal overhead. In this paper, we present For-LySa, an instantiation of the DEGAS approach for authentication...... analysis, which exploits an existing analysis tool developed for the process calculus LySa. We discuss what information is needed for the analysis, and how to build the UML model of an authentication protocol in such a way that the needed information can be extracted from the model. We then present our...

  5. A UML profile for the OBO relation ontology

    Science.gov (United States)

    2012-01-01

    Background Ontologies have increasingly been used in the biomedical domain, which has prompted the emergence of different initiatives to facilitate their development and integration. The Open Biological and Biomedical Ontologies (OBO) Foundry consortium provides a repository of life-science ontologies, which are developed according to a set of shared principles. This consortium has developed an ontology called OBO Relation Ontology aiming at standardizing the different types of biological entity classes and associated relationships. Since ontologies are primarily intended to be used by humans, the use of graphical notations for ontology development facilitates the capture, comprehension and communication of knowledge between its users. However, OBO Foundry ontologies are captured and represented basically using text-based notations. The Unified Modeling Language (UML) provides a standard and widely-used graphical notation for modeling computer systems. UML provides a well-defined set of modeling elements, which can be extended using a built-in extension mechanism named Profile. Thus, this work aims at developing a UML profile for the OBO Relation Ontology to provide a domain-specific set of modeling elements that can be used to create standard UML-based ontologies in the biomedical domain. Results We have studied the OBO Relation Ontology, the UML metamodel and the UML profiling mechanism. Based on these studies, we have proposed an extension to the UML metamodel in conformance with the OBO Relation Ontology and we have defined a profile that implements the extended metamodel. Finally, we have applied the proposed UML profile in the development of a number of fragments from different ontologies. Particularly, we have considered the Gene Ontology (GO), the PRotein Ontology (PRO) and the Xenopus Anatomy and Development Ontology (XAO). Conclusions The use of an established and well-known graphical language in the development of biomedical ontologies provides a more

  6. Querying UML models using OCL and Prolog: A performance study

    NARCIS (Netherlands)

    Chimiak-Opoka, J.; Felderer, M.; Lenz, C.; Lange, C.F.J.

    2008-01-01

    The size of unified modeling language (UML) models used in practice is very large and ranges up to hundreds and thousands of classes. Querying of these models is used to support their quality assessment by information filtering and aggregating. For both, human cognition and automated analysis, there

  7. Functional Size Measurement applied to UML-based user requirements

    NARCIS (Netherlands)

    van den Berg, Klaas; Dekkers, Ton; Oudshoorn, Rogier; Dekkers, T.

    There is a growing interest in applying standardized methods for Functional Size Measurement (FSM) to Functional User Requirements (FUR) based on models in the Unified Modelling Language (UML). No consensus exists on this issue. We analyzed the demands that FSM places on FURs. We propose a

  8. Event Modeling in UML. Unified Modeling Language and Unified Process

    DEFF Research Database (Denmark)

    Bækgaard, Lars

    2002-01-01

    We show how events can be modeled in terms of UML. We view events as change agents that have consequences and as information objects that represent information. We show how to create object-oriented structures that represent events in terms of attributes, associations, operations, state charts......, and messages. We outline a run-time environment for the processing of events with multiple participants....

  9. Verifying OCL specifications of UML models : tool support and compositionality

    NARCIS (Netherlands)

    Kyas, Marcel

    2006-01-01

    The Unified Modelling Language (UML) and the Object Constraint Language (OCL) serve as specification languages for embedded and real-time systems used in a safety-critical environment. In this dissertation class diagrams, object diagrams, and OCL constraints are formalised. The formalisation

  10. QoS modelling and analysis with UML-statecharts: the StoCharts approach

    OpenAIRE

    Jansen, D.N.; Haverkort, Boudewijn R.H.M.; Hermanns, H.; Katoen, Joost P.

    2005-01-01

    The UML is an influential and widespread notation for high-level modelling of information processing systems. UML statechart diagrams are a graphical language to describe system behaviour. They consitute one of the most intensively-used formalisms comprised by the UML. However, statechart diagrams are lacking concepts for describing real-time, performance, dependability and quality of service (QoS) characteristics at a behavioural level.This note describes a QoS-oriented extension of UML stat...

  11. Rewriting and suppressing UMLS terms for improved biomedical term identification

    Directory of Open Access Journals (Sweden)

    Hettne Kristina M

    2010-03-01

    Full Text Available Abstract Background Identification of terms is essential for biomedical text mining.. We concentrate here on the use of vocabularies for term identification, specifically the Unified Medical Language System (UMLS. To make the UMLS more suitable for biomedical text mining we implemented and evaluated nine term rewrite and eight term suppression rules. The rules rely on UMLS properties that have been identified in previous work by others, together with an additional set of new properties discovered by our group during our work with the UMLS. Our work complements the earlier work in that we measure the impact on the number of terms identified by the different rules on a MEDLINE corpus. The number of uniquely identified terms and their frequency in MEDLINE were computed before and after applying the rules. The 50 most frequently found terms together with a sample of 100 randomly selected terms were evaluated for every rule. Results Five of the nine rewrite rules were found to generate additional synonyms and spelling variants that correctly corresponded to the meaning of the original terms and seven out of the eight suppression rules were found to suppress only undesired terms. Using the five rewrite rules that passed our evaluation, we were able to identify 1,117,772 new occurrences of 14,784 rewritten terms in MEDLINE. Without the rewriting, we recognized 651,268 terms belonging to 397,414 concepts; with rewriting, we recognized 666,053 terms belonging to 410,823 concepts, which is an increase of 2.8% in the number of terms and an increase of 3.4% in the number of concepts recognized. Using the seven suppression rules, a total of 257,118 undesired terms were suppressed in the UMLS, notably decreasing its size. 7,397 terms were suppressed in the corpus. Conclusions We recommend applying the five rewrite rules and seven suppression rules that passed our evaluation when the UMLS is to be used for biomedical term identification in MEDLINE. A software

  12. SISTEM INFORMASI PENJUALAN TAS BERBASIS WEB DENGAN PEMODELAN UML

    Directory of Open Access Journals (Sweden)

    Nurul Azwanti

    2017-02-01

    Full Text Available At this time many people who use the website instead of just looking for information, but rather as a land promotion, sales and other activities that could open up opportunities for businesses. Mendi Shopping is one of the businesses engaged in the sale of bags that are already using the internet as a media sales services. The internet service is up. However, in the recording of transactions still use manual recording that led to the frequent occurrence of data loss sales and had to repeat the recording back so that the generated report is not accurate. Use of the Website can be used as a media sales in Mendi Shopping. Unified Modeling Language (UML is a tool or tools that can be used in doing the design of the system to be built. UML can describe clearly the information systems that will be built. Shopping Mendi to assist in storing their data, created a database using MySQL as a storage medium. In addition, it can reduce errors and data loss in data processing sales. The website can also be a media campaign to inform the latest products and berkulitas so as to increase the sales charts in Mendi Shopping. Keywords: website, sales, MySQL, UML Pada saat ini banyak individu yang menggunakan website bukan hanya sekedar mencari informasi saja, melainkan sebagai lahan promosi, penjualan dan aktivitas lainnya yang dapat membuka peluang untuk bisnis. Mendi Shopping merupakan salah satu usaha yang bergerak dibidang penjualan tas yang sudah menggunakan layanan internet sebagai media penjualan. Layanan internet tersebut adalah Facebook. Namun, dalam pencatatan transaksinya masih menggunakan pencatatan secara manual yang menyebabkan sering terjadinya kehilangan data penjualan dan harus mengulang pencatatan kembali sehingga laporan yang dihasilkan tidak akurat. Penggunaan Website dapat dijadikan sebagai media penjualan pada Mendi Shopping. Unified Modeling Language (UML merupakan tools atau alat bantu yang dapat digunakan dalam melakukan desain terhadap

  13. Methods of checking general safety criteria in UML statechart specifications

    International Nuclear Information System (INIS)

    Pap, Zsigmond; Majzik, Istvan; Pataricza, Andras; Szegi, Andras

    2005-01-01

    This paper describes methods and tools for safety analysis of UML statechart specifications. A comprehensive set of general safety criteria including completeness and consistency is applied in automated analysis. Analysis techniques are based on OCL expressions, graph transformations and reachability analysis. Two canonical intermediate representations of the statechart specification are introduced. They are suitable for straightforward implementation of checker methods and for the support of the proof of the correctness and soundness of the applied analysis. One of them also serves as a basis of the metamodel of a variant of UML statecharts proposed for the specification of safety-critical control systems. The analysis is extended to object-oriented specifications. Examples illustrate the application of the checker methods implemented by an automated tool-set

  14. Auditing the multiply-related concepts within the UMLS.

    Science.gov (United States)

    Mougin, Fleur; Grabar, Natalia

    2014-10-01

    This work focuses on multiply-related Unified Medical Language System (UMLS) concepts, that is, concepts associated through multiple relations. The relations involved in such situations are audited to determine whether they are provided by source vocabularies or result from the integration of these vocabularies within the UMLS. We study the compatibility of the multiple relations which associate the concepts under investigation and try to explain the reason why they co-occur. Towards this end, we analyze the relations both at the concept and term levels. In addition, we randomly select 288 concepts associated through contradictory relations and manually analyze them. At the UMLS scale, only 0.7% of combinations of relations are contradictory, while homogeneous combinations are observed in one-third of situations. At the scale of source vocabularies, one-third do not contain more than one relation between the concepts under investigation. Among the remaining source vocabularies, seven of them mainly present multiple non-homogeneous relations between terms. Analysis at the term level also shows that only in a quarter of cases are the source vocabularies responsible for the presence of multiply-related concepts in the UMLS. These results are available at: http://www.isped.u-bordeaux2.fr/ArticleJAMIA/results_multiply_related_concepts.aspx. Manual analysis was useful to explain the conceptualization difference in relations between terms across source vocabularies. The exploitation of source relations was helpful for understanding why some source vocabularies describe multiple relations between a given pair of terms. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  15. Using UML to Model Web Services for Automatic Composition

    OpenAIRE

    Amal Elgammal; Mohamed El-Sharkawi

    2010-01-01

    There is a great interest paid to the web services paradigm nowadays. One of the most important problems related to the web service paradigm is the automatic composition of web services. Several frameworks have been proposed to achieve this novel goal. The most recent and richest framework (model) is the Colombo model. However, even for experienced developers, working with Colombo formalisms is low-level, very complex and timeconsuming. We propose to use UML (Unified Modeling Language) to mod...

  16. Modeling Value Chain Analysis of Distance Education using UML

    Science.gov (United States)

    Acharya, Anal; Mukherjee, Soumen

    2010-10-01

    Distance education continues to grow as a methodology for the delivery of course content in higher education in India as well as abroad. To manage this growing demand and to provide certain flexibility, there must be certain strategic planning about the use of ICT tools. Value chain analysis is a framework for breaking down the sequence of business functions into a set of activities through which utility could be added to service. Thus it can help to determine the competitive advantage that is enjoyed by an institute. To implement these business functions certain visual representation is required. UML allows for this representation by using a set of structural and behavioral diagrams. In this paper, the first section defines a framework for value chain analysis and highlights its advantages. The second section gives a brief overview of related work in this field. The third section gives a brief discussion on distance education. The fourth section very briefly introduces UML. The fifth section models value chain of distance education using UML. Finally we discuss the limitations and the problems posed in this domain.

  17. 基于UML statecharts 测试方法的研究%Research of testing method based on UML statecharts

    Institute of Scientific and Technical Information of China (English)

    占学德

    2006-01-01

    @@ Unified modeling language (UML) is a powerful graphical modeling language with intuitional meaning.It provides various diagrams to depict system characteristics and complex environment from different viewpoints and different application layers. UML-based software development and modeling environments have been widely accepted in industry, including areas in which safety is an important issue such as spaceflight,defense, automobile, etc.

  18. Model-based testing with UML applied to a roaming algorithm for bluetooth devices.

    Science.gov (United States)

    Dai, Zhen Ru; Grabowski, Jens; Neukirchen, Helmut; Pals, Holger

    2004-11-01

    In late 2001, the Object Management Group issued a Request for Proposal to develop a testing profile for UML 2.0. In June 2003, the work on the UML 2.0 Testing Profile was finally adopted by the OMG. Since March 2004, it has become an official standard of the OMG. The UML 2.0 Testing Profile provides support for UML based model-driven testing. This paper introduces a methodology on how to use the testing profile in order to modify and extend an existing UML design model for test issues. The application of the methodology will be explained by applying it to an existing UML Model for a Bluetooth device.

  19. The Neighborhood Auditing Tool: A Hybrid Interface for Auditing the UMLS

    OpenAIRE

    Morrey, C. Paul; Geller, James; Halper, Michael; Perl, Yehoshua

    2009-01-01

    The UMLS’s integration of more than 100 source vocabularies, not necessarily consistent with one another, causes some inconsistencies. The purpose of auditing the UMLS is to detect such inconsistencies and to suggest how to resolve them while observing the requirement of fully representing the content of each source in the UMLS. A software tool, called the Neighborhood Auditing Tool (NAT), that facilitates UMLS auditing is presented. The NAT supports “neighborhood-based” auditing, where, at a...

  20. Associating clinical archetypes through UMLS Metathesaurus term clusters.

    Science.gov (United States)

    Lezcano, Leonardo; Sánchez-Alonso, Salvador; Sicilia, Miguel-Angel

    2012-06-01

    Clinical archetypes are modular definitions of clinical data, expressed using standard or open constraint-based data models as the CEN EN13606 and openEHR. There is an increasing archetype specification activity that raises the need for techniques to associate archetypes to support better management and user navigation in archetype repositories. This paper reports on a computational technique to generate tentative archetype associations by mapping them through term clusters obtained from the UMLS Metathesaurus. The terms are used to build a bipartite graph model and graph connectivity measures can be used for deriving associations.

  1. PERFIL PARA REPRESENTAR UNA ARQUITECTURA DE COMPONENTES EN UML

    Directory of Open Access Journals (Sweden)

    Fernando Orejas Valdés

    2006-04-01

    Full Text Available

    El lenguaje unificado de modelado (Unified Modeling Language, UML es un lenguaje de modelado estándar para problemas generales, sin embargo, es necesario extenderlo para dominios específicos como puede ser el caso de determinadas arquitecturas. Aquí se presenta una extensión mediante un perfil para una arquitectura de componentes y conectores genéricos.

  2. Pemodelan UML Sistem Informasi Geografis Pasar Tradisional Kota Pekanbaru

    Directory of Open Access Journals (Sweden)

    Sutejo Sutejo

    2017-01-01

    Full Text Available AbstrakDunia sistem informasi terdapat banyak model sistem informasi, kaitan pasar dengan sistem informasi geografis adalah untuk memberikan berbagai macam informasi, terutama letak geografis pasar tersebut. Pentingnya informasi ini memberi banyak inspirasi terhadap pembuat model untuk merancang sistem-sistem yang mendekati dunia nyata. Model sistem informasi juga diharapkan dapat digunakan sebagai alat prediksi kejadian di masa depan dengan mendasarkan pada data yang ada pada masa lalu dan masa sekarang. Sistem Informasi Geografis (SIG ini di rancang untuk mengumpulkan data, meyimpan dan mengubah data, serta menganalisis objek beserta data geografis yang bersifat penting untuk di analisis. GIS yang disajikan dengan berbasis web pada perancangan ini juga dapat digunakan sebagai alat pemberian informasi kepada masyarakat luas. Hasil penelitian dengan pemodelan UML (Unified Modelling Language sangat membantu dalam proses perancangan sebuah sistem informasi geografis pasar tradisional serta aplikasi sistem informasi geografis pasar tradisional berbasis web ini dapat digunakan sebagai sarana informasi pasar, khususnya bagi para calon pedagang yang ingin berdagang di salah satu pasar tradisional yang ada di Kota Pekanbaru. Kata Kunci : Sistem Informasi Geografis, Web, Pasar Tradisional, Pemodelan, UML. AbstractThe world of information systems provides many models of information systems, the link of market with a geographic information system is to provide various kinds of information, specially the geographical markets. The importance of this information gives a lot of inspiration for the model makers to design systems that approximates the real world. Model of information system is also expected to be used as predictors of future events by basing on the existing data on past and present. Geographic Information Systems (GIS is designed to collect data, store and modify data, and analyzing object along with geographic data which is important for

  3. UML Modeling for Dynamic Logistics System Based on DEVS

    OpenAIRE

    Zhang Zhiyong; Liu Jie; Zhang Xinhui

    2013-01-01

    DEVS is a hierarchical and modular system descriptive method. However, it cannot describe dynamic process and relationship of system members. This article has proposed a way to extend UML using stereotype, making it suitable for simulation modeling. To build a modeling tool, we defined atomic model class and coupled model class, both of which are in line with not only DEVS’s hierarchical and modular requirements but also UML’s object-oriented characteristics. At last, we use the tool to analy...

  4. Verification-Driven Slicing of UML/OCL Models

    DEFF Research Database (Denmark)

    Shaikh, Asadullah; Clarisó Viladrosa, Robert; Wiil, Uffe Kock

    2010-01-01

    computational complexity can limit their scalability. In this paper, we consider a specific static model (UML class diagrams annotated with unrestricted OCL constraints) and a specific property to verify (satisfiability, i.e., “is it possible to create objects without violating any constraint?”). Current...... approaches to this problem have an exponential worst-case runtime. We propose a technique to improve their scalability by partitioning the original model into submodels (slices) which can be verified independently and where irrelevant information has been abstracted. The definition of the slicing procedure...

  5. SSBRP Communication & Data System Development using the Unified Modeling Language (UML)

    Science.gov (United States)

    Windrem, May; Picinich, Lou; Givens, John J. (Technical Monitor)

    1998-01-01

    The Unified Modeling Language (UML) is the standard method for specifying, visualizing, and documenting the artifacts of an object-oriented system under development. UML is the unification of the object-oriented methods developed by Grady Booch and James Rumbaugh, and of the Use Case Model developed by Ivar Jacobson. This paper discusses the application of UML by the Communications and Data Systems (CDS) team to model the ground control and command of the Space Station Biological Research Project (SSBRP) User Operations Facility (UOF). UML is used to define the context of the system, the logical static structure, the life history of objects, and the interactions among objects.

  6. USING UML SCENARIOS IN B2B SYSTEMS

    Directory of Open Access Journals (Sweden)

    A. Jakimi

    2010-05-01

    Full Text Available Scenarios has become a popular technique for requirements elicitation and specification building. Since scenarios capture only partial descriptions of the system behavior, an approach for scenario composition and/or integration is needed to produce more complete specifications. The Unified Modeling Language (UML, which has become a standard notation for object-oriented modeling, provides a suitable framework for scenario acquisition using Use Case diagrams and Sequence or Collaboration diagrams. In this paper, we suggest an algorithmic and tool support for composing and integrating scenarios that are represented in form of sequence diagrams. We suggest four operators (;: sequential operator, ||: concurrent operator, ?: conditional operator and  * :iteration operator to compose a set of scenarios that describe a use case of a given system. In this paper, we suggest also to apply the scenario approach to B2B systems (Business to Business. We propose to develop B2B systems as a three activities process deriving formal specifications and code skeletons from UML scenarios. Activities of this proposed process are generally automatic and are supported by a set of developed algorithms and tools.

  7. Enterprise architecture evaluation using architecture framework and UML stereotypes

    Directory of Open Access Journals (Sweden)

    Narges Shahi

    2014-08-01

    Full Text Available There is an increasing need for enterprise architecture in numerous organizations with complicated systems with various processes. Support for information technology, organizational units whose elements maintain complex relationships increases. Enterprise architecture is so effective that its non-use in organizations is regarded as their institutional inability in efficient information technology management. The enterprise architecture process generally consists of three phases including strategic programing of information technology, enterprise architecture programing and enterprise architecture implementation. Each phase must be implemented sequentially and one single flaw in each phase may result in a flaw in the whole architecture and, consequently, in extra costs and time. If a model is mapped for the issue and then it is evaluated before enterprise architecture implementation in the second phase, the possible flaws in implementation process are prevented. In this study, the processes of enterprise architecture are illustrated through UML diagrams, and the architecture is evaluated in programming phase through transforming the UML diagrams to Petri nets. The results indicate that the high costs of the implementation phase will be reduced.

  8. Dependability modeling and assessment in UML-based software development.

    Science.gov (United States)

    Bernardi, Simona; Merseguer, José; Petriu, Dorina C

    2012-01-01

    Assessment of software nonfunctional properties (NFP) is an important problem in software development. In the context of model-driven development, an emerging approach for the analysis of different NFPs consists of the following steps: (a) to extend the software models with annotations describing the NFP of interest; (b) to transform automatically the annotated software model to the formalism chosen for NFP analysis; (c) to analyze the formal model using existing solvers; (d) to assess the software based on the results and give feedback to designers. Such a modeling→analysis→assessment approach can be applied to any software modeling language, be it general purpose or domain specific. In this paper, we focus on UML-based development and on the dependability NFP, which encompasses reliability, availability, safety, integrity, and maintainability. The paper presents the profile used to extend UML with dependability information, the model transformation to generate a DSPN formal model, and the assessment of the system properties based on the DSPN results.

  9. Source Authenticity in the UMLS – A Case Study of the Minimal Standard Terminology

    Science.gov (United States)

    Elhanan, Gai; Huang, Kuo-Chuan; Perl, Yehoshua

    2010-01-01

    As the UMLS integrates multiple source vocabularies, the integration process requires that certain adaptation be applied to the source. Our interest is in examining the relationship between the UMLS representation of a source vocabulary and the source vocabulary itself. We investigated the integration of the Minimal Standard Terminology (MST) into the UMLS in order to examine how close its UMLS representation is to the source MST. The MST was conceived as a “minimal” list of terms and structure intended for use within computer systems to facilitate standardized reporting of gastrointestinal endoscopic examinations. Although the MST has an overall schema and implied relationship structure, many of the UMLS integrated MST terms were found to be hierarchically orphaned, and with lateral relationships that do not closely adhere to the source MST. Thus, the MST representation within the UMLS significantly differs from that of the source MST. These representation discrepancies may affect the usability of the MST representation in the UMLS for knowledge acquisition. Furthermore, they pose a problem from the perspective of application developers. While these findings may not necessarily apply to other source terminologies, they highlight the conflict between preservation of authentic concept orientation and the UMLS overall desire to provide fully specified names for all source terms. PMID:20692366

  10. From system requirements to source code: transitions in UML and RUP

    Directory of Open Access Journals (Sweden)

    Stanisław Wrycza

    2011-06-01

    Full Text Available There are many manuals explaining language specification among UML-related books. Only some of books mentioned concentrate on practical aspects of using the UML language in effective way using CASE tools and RUP. The current paper presents transitions from system requirements specification to structural source code, useful while developing an information system.

  11. On the suitability of UML 2.0 activity diagrams for business process modelling

    NARCIS (Netherlands)

    Russell, N.C.; Aalst, van der W.M.P.; Hofstede, ter A.H.M.; Wohed, P.; Stumptner, M.; Hartmann, S.; Kiyoki, Y.

    2006-01-01

    UML is posited as the 'swiss army knife' for systems modelling and design activities. It embodies a number of modelling formalisms that have broad applicability in capturing both the static and dynamic aspects of software systems. One area of UML that has received particular attention is that of

  12. Visual syntax of UML class and package diagram constructs as an ontology

    CSIR Research Space (South Africa)

    Thomas, A

    2015-11-01

    Full Text Available and package diagrams are two diagrams of UML. The motivation for this work is twofold; UML lacks a formal visual syntax specification and ontologies are under-explored for visual syntax specifications. The work in this paper, therefore, explores using...

  13. Assessing and improving the quality of modeling : a series of empirical studies about the UML

    NARCIS (Netherlands)

    Lange, C.F.J.

    2007-01-01

    Assessing and Improving the Quality of Modeling A Series of Empirical Studies about the UML This thesis addresses the assessment and improvement of the quality of modeling in software engineering. In particular, we focus on the Unified Modeling Language (UML), which is the de facto standard in

  14. UML Profile for Mining Process: Supporting Modeling and Simulation Based on Metamodels of Activity Diagram

    Directory of Open Access Journals (Sweden)

    Andrea Giubergia

    2014-01-01

    Full Text Available An UML profile describes lightweight extension mechanism to the UML by defining custom stereotypes, tagged values, and constraints. They are used to adapt UML metamodel to different platforms and domains. In this paper we present an UML profile for models supporting event driving simulation. In particular, we use the Arena simulation tool and we focus on the mining process domain. Profiles provide an easy way to obtain well-defined specifications, regulated by the Object Management Group (OMG. They can be used as a presimulation technique to obtain solid models for the mining industry. In this work we present a new profile to extend the UML metamodel; in particular we focus on the activity diagram. This extended model is applied to an industry problem involving loading and transportation of minerals in the field of mining process.

  15. PERANCANGAN ATURAN TRANSFORMASI UML – SYSTEMC DALAM PERANCANGAN EMBEDDED SYSTEM

    Directory of Open Access Journals (Sweden)

    Maman Abdurohman

    2012-05-01

    Full Text Available Pemodelan adalah salah satu proses awal dalam pengembangan suatu aplikasi atau produk. Tahap ini dilakukan untuk meminimalkan kesalahan pada produk akhir. Salah satu metode pemodelan berorientasi objek yang banyak digunakan adalah pemodelan UML (Unified Modeling Language. Dalam UML suatu sistem dipandang sebagai kumpulan objek yang memiliki atribut dan method. SystemC adalah bahasa perancangan perangkat keras yang berbasis C++. SystemC merupakan sebuah library yang mendefinisikan tipe-tipe komponen perangkat keras. Dalam pemodelan bersama perangkat keras dan perangkat lunak, UML dan SystemC memiliki kemampuan yang sama. Pada paper ini dilakukan analisis proses transformasi dari pemodelan berorientasi objek dengan UML dan implementasi dengan menggunakan SystemC. Hasil penelitian menunjukan bahwa proses transformasi UML-SystemC dapat dilakukan karena keduanya memiliki nature yang sama sebagai lingkungan yang dapat merancang bersama hardware dan software. Perangkat yang digunakan untuk penelitian ini adalah Rational Rose dan SystemC. Modeling is one of the first process in the development of an application or product. This phase is done to minimize errors in the final product. One method in object-oriented modeling that is widely used is UML (Unified Modeling Language. In UML a system is seen as a collection of objects that have attributes and methods. SystemC is a hardware design language based on C++. SystemC is a library that defines the types of hardware components. In a joint modeling of hardware and software, UML and SystemC have similar capabilities. In this paper, researchers analyzed the transformation of object-oriented modeling with UML and the implementation by using SystemC. The results shows that the transformation process of UML-SystemC can be done because both have the same nature as the environment that can design both hardware and software. The device used for this study is the Rational Rose and SystemC.

  16. Visual Modelling of Data Warehousing Flows with UML Profiles

    Science.gov (United States)

    Pardillo, Jesús; Golfarelli, Matteo; Rizzi, Stefano; Trujillo, Juan

    Data warehousing involves complex processes that transform source data through several stages to deliver suitable information ready to be analysed. Though many techniques for visual modelling of data warehouses from the static point of view have been devised, only few attempts have been made to model the data flows involved in a data warehousing process. Besides, each attempt was mainly aimed at a specific application, such as ETL, OLAP, what-if analysis, data mining. Data flows are typically very complex in this domain; for this reason, we argue, designers would greatly benefit from a technique for uniformly modelling data warehousing flows for all applications. In this paper, we propose an integrated visual modelling technique for data cubes and data flows. This technique is based on UML profiling; its feasibility is evaluated by means of a prototype implementation.

  17. Auditing hierarchical cycles to locate other inconsistencies in the UMLS.

    Science.gov (United States)

    Halper, Michael; Morrey, C Paul; Chen, Yan; Elhanan, Gai; Hripcsak, George; Perl, Yehoshua

    2011-01-01

    A cycle in the parent relationship hierarchy of the UMLS is a configuration that effectively makes some concept(s) an ancestor of itself. Such a structural inconsistency can easily be found automatically. A previous strategy for disconnecting cycles is to break them with the deletion of one or more parent relationships-irrespective of the correctness of the deleted relationships. A methodology is introduced for auditing of cycles that seeks to discover and delete erroneous relationships only. Cycles involving three concepts are the primary consideration. Hypotheses about the high probability of locating an erroneous parent relationship in a cycle are proposed and confirmed with statistical confidence and lend credence to the auditing approach. A cycle may serve as an indicator of other non-structural inconsistencies that are otherwise difficult to detect automatically. An extensive auditing example shows how a cycle can indicate further inconsistencies.

  18. Auditing Hierarchical Cycles to Locate Other Inconsistencies in the UMLS

    Science.gov (United States)

    Halper, Michael; Morrey, C. Paul; Chen, Yan; Elhanan, Gai; Hripcsak, George; Perl, Yehoshua

    2011-01-01

    A cycle in the parent relationship hierarchy of the UMLS is a configuration that effectively makes some concept(s) an ancestor of itself. Such a structural inconsistency can easily be found automatically. A previous strategy for disconnecting cycles is to break them with the deletion of one or more parent relationships—irrespective of the correctness of the deleted relationships. A methodology is introduced for auditing of cycles that seeks to discover and delete erroneous relationships only. Cycles involving three concepts are the primary consideration. Hypotheses about the high probability of locating an erroneous parent relationship in a cycle are proposed and confirmed with statistical confidence and lend credence to the auditing approach. A cycle may serve as an indicator of other non-structural inconsistencies that are otherwise difficult to detect automatically. An extensive auditing example shows how a cycle can indicate further inconsistencies. PMID:22195107

  19. Automatic Generation of Test Cases from UML Models

    Directory of Open Access Journals (Sweden)

    Constanza Pérez

    2018-04-01

    Full Text Available [Context] The growing demand for high-quality software has caused the industry to incorporate processes to enable them to comply with these standards, but increasing the cost of development. A strategy to reduce this cost is to incorporate quality evaluations from early stages of software development. A technique that facilitates this evaluation is the model-based testing, which allows to generate test cases at early phases using as input the conceptual models of the system. [Objective] In this paper, we introduce TCGen, a tool that enables the automatic generation of abstract test cases starting from UML conceptual models. [Method] The design and implementation of TCGen, a technique that applies different testing criteria to class diagrams and state transition diagrams to generates test cases, is presented as a model-based testing approach. To do that, TCGen uses UML models, which are widely used at industry and a set of algorithms that recognize the concepts in the models in order to generate abstract test cases. [Results] An exploratory experimental evaluation has been performed to compare the TCGen tool with traditional testing. [Conclusions] Even though the exploratory evaluation shows promising results, it is necessary to perform more empirical evaluations in order to generalize the results. Abstract (in Spanish: [Contexto] La creciente demanda de software de alta calidad ha provocado que la industria incorpore procesos para permitirles cumplir con estos estándares, pero aumentando el costo del desarrollo. Una estrategia para reducir este costo es incorporar evaluaciones de calidad desde las primeras etapas del desarrollo del software. Una técnica que facilita esta evaluación es la prueba basada en modelos, que permite generar casos de prueba en fases tempranas utilizando como entrada los modelos conceptuales del sistema. [Objetivo] En este artículo, presentamos TCGen, una herramienta que permite la generación automática de casos de

  20. Augmented halal food traceability system: analysis and design using UML

    Science.gov (United States)

    Usman, Y. V.; Fauzi, A. M.; Irawadi, T. T.; Djatna, T.

    2018-04-01

    Augmented halal food traceability is expanding the range of halal traceability in food supply chain where currently only available for tracing from the source of raw material to the industrial warehouse or inbound logistic. The halal traceability system must be developed in the integrated form that includes inbound and outbound logistics. The objective of this study was to develop a reliable initial model of integrated traceability system of halal food supply chain. The method was based on unified modeling language (UML) such as use case, sequence, and business process diagram. A goal programming model was formulated considering two objective functions which include (1) minimization of risk of halal traceability failures happened potentially during outbound logistics activities and (2) maximization of quality of halal product information. The result indicates the supply of material is the most important point to be considered in minimizing the risk of failure of halal food traceability system whereas no risk observed in manufacturing and distribution.

  1. The Use of UML to Development of a Railway Interlocking System

    Directory of Open Access Journals (Sweden)

    Karol Rastocny

    2003-01-01

    Full Text Available The paper deals with problems of using the Unifield Modeling Lanfuage (UML in developmentt of new railway interlocking and signalling systems. A simplifield example of the control circuit of a point machine is used to demonstrate an object-oriented approach to specifying the functional safety requirements. An informal specification given by the relevant technical standart is used as a starting point and results in semi-formal specification based on UML model. Advantages of the presented approach are discussed and new trends of increasing formality of UML models are indicated within conclusions.

  2. MODELAGEM SISTÊMICA DE PROJETOS DE AEC EM UML

    Directory of Open Access Journals (Sweden)

    Rita Cristina Ferreira

    2007-11-01

    Full Text Available O uso intensivo de Sistemas de Informação é uma possível solução para a integração das atividades de projeto em AEC, permitindo que decisões sejam tomadas ainda na fase de projeto e, conseqüentemente, evitando-se retrabalhos em obra. Neste sentido, esforços têm sido realizados para padronizar conceitos e terminologias de AEC, permitindo a troca e armazenagem de informações, como a norma ISO 12006-2 e os padrões estabelecidos pelo IFC. Ambas são baseadas na linguagem EXPRESS, assim como é o padrão industrial STEP. Entretanto, as representações de informação usadas na indústria de produtos não são as mais adequadas para a Engenharia de Software, responsável pelo desenvolvimento de Sistemas de Informação, onde as representações semânticas envolvem não somente a representação estrutural da informação, mas também a representação comportamental. Este artigo contribui com uma visão de implementação em UML da informação de um projeto de AEC e tornam explícitas, sob a ótica do desenvolvimento de software, as relações semânticas existentes. Os resultados desta pesquisa foram obtidos através da realização de um estudo de caso de projeto de produção em CAD 3D dos subsistemas alvenaria e revestimento para um edifício residencial. A partir das observações do estudo de caso foi feita a modelagem em UML dos objetos pertinentes. O principal resultado obtido foi a representação explícita das interfaces entre objetos AEC.

  3. ROLE OF UML SEQUENCE DIAGRAM CONSTRUCTS IN OBJECT LIFECYCLE CONCEPT

    Directory of Open Access Journals (Sweden)

    Miroslav Grgec

    2007-06-01

    Full Text Available When modeling systems and using UML concepts, a real system can be viewed in several ways. The RUP (Rational Unified Process defines the "4 + 1 view": 1. Logical view (class diagram (CD, object diagram (OD, sequence diagram (SD, collaboration diagram (COD, state chart diagram (SCD, activity diagram (AD, 2.Process view (use case diagram, CD, OD, SD, COD, SCD, AD, 3. Development view (package diagram, component diagram, 4. Physical view (deployment diagram, and 5. Use case view (use case diagram, OD, SD, COD, SCD, AD which combines the four mentioned above. With sequence diagram constructs we are describing object behavior in scope of one use case and their interaction. Each object in system goes through a so called lifecycle (create, supplement object with data, use object, decommission object. The concept of the object lifecycle is used to understand and formalize the behavior of objects from creation to deletion. With help of sequence diagram concepts our paper will describe the way of interaction modeling between objects through lifeline of each of them, and their importance in software development.

  4. Perancangan Aplikasi Informasi SMS untuk Alumni Unsoed Menggunakan UML (Unified Modeling Language

    Directory of Open Access Journals (Sweden)

    Bangun Wijayanto

    2007-02-01

    Full Text Available Unified Modeling Language (UML is a language which have come to the standard in industry to visualize, design and document the software system. Using UML we can make model for All software application type, where the application can also written in many language. SMS (Short Message Service is the best choice to solve geographic problems in spreading information to the alumni Unsoed. The aim of this research is to compile notation of UML (Unified Modeling Language in development of SMS Server for Alumni Unsoed. This research is conducted with software engineer method. The design result of software SMS alumni Unsoed present that UML (Unified Modeling Language help in design and software programming

  5. Generación de código Hibernate desde modelos UML

    OpenAIRE

    Nogueiro Mariscal, Alejandro

    2012-01-01

    Este proyecto consiste en un generador de código para Hibernate desde modelos UML. El código generado es el conjunto de clases del modelo implementadas en Java con una serie de anotaciones JPA 2.0. Estas clases, mediante Hibernate, sirven para añadir persistencia a nuestro código. Los modelos UML tendrán una serie de anotaciones para poder transformarlos correctamente.

  6. UML as a cell and biochemistry modeling language.

    Science.gov (United States)

    Webb, Ken; White, Tony

    2005-06-01

    The systems biology community is building increasingly complex models and simulations of cells and other biological entities, and are beginning to look at alternatives to traditional representations such as those provided by ordinary differential equations (ODE). The lessons learned over the years by the software development community in designing and building increasingly complex telecommunication and other commercial real-time reactive systems, can be advantageously applied to the problems of modeling in the biology domain. Making use of the object-oriented (OO) paradigm, the unified modeling language (UML) and Real-Time Object-Oriented Modeling (ROOM) visual formalisms, and the Rational Rose RealTime (RRT) visual modeling tool, we describe a multi-step process we have used to construct top-down models of cells and cell aggregates. The simple example model described in this paper includes membranes with lipid bilayers, multiple compartments including a variable number of mitochondria, substrate molecules, enzymes with reaction rules, and metabolic pathways. We demonstrate the relevance of abstraction, reuse, objects, classes, component and inheritance hierarchies, multiplicity, visual modeling, and other current software development best practices. We show how it is possible to start with a direct diagrammatic representation of a biological structure such as a cell, using terminology familiar to biologists, and by following a process of gradually adding more and more detail, arrive at a system with structure and behavior of arbitrary complexity that can run and be observed on a computer. We discuss our CellAK (Cell Assembly Kit) approach in terms of features found in SBML, CellML, E-CELL, Gepasi, Jarnac, StochSim, Virtual Cell, and membrane computing systems.

  7. Quality Assurance of UMLS Semantic Type Assignments Using SNOMED CT Hierarchies.

    Science.gov (United States)

    Gu, H; Chen, Y; He, Z; Halper, M; Chen, L

    2016-01-01

    The Unified Medical Language System (UMLS) is one of the largest biomedical terminological systems, with over 2.5 million concepts in its Metathesaurus repository. The UMLS's Semantic Network (SN) with its collection of 133 high-level semantic types serves as an abstraction layer on top of the Metathesaurus. In particular, the SN elaborates an aspect of the Metathesaurus's concepts via the assignment of one or more types to each concept. Due to the scope and complexity of the Metathesaurus, errors are all but inevitable in this semantic-type assignment process. To develop a semi-automated methodology to help assure the quality of semantic-type assignments within the UMLS. The methodology uses a cross-validation strategy involving SNOMED CT's hierarchies in combination with UMLS semantic types. Semantically uniform, disjoint concept groups are generated programmatically by partitioning the collection of all concepts in the same SNOMED CT hierarchy according to their respective semantic-type assignments in the UMLS. Domain experts are then called upon to review the concepts in any group having a small number of concepts. It is our hypothesis that a semantic-type assignment combination applicable only to a very small number of concepts in a SNOMED CT hierarchy is an indicator of potential problems. The methodology was applied to the UMLS 2013AA release along with the SNOMED CT from January 2013. An overall error rate of 33% was found for concepts proposed by the quality-assurance methodology. Supporting our hypothesis, that number was four times higher than the error rate found in control samples. The results show that the quality-assurance methodology can aid in effective and efficient identification of UMLS semantic-type assignment errors.

  8. Use of Unified Modeling Language (UML) in Model-Based Development (MBD) For Safety-Critical Applications

    Science.gov (United States)

    2014-12-01

    ControlStation switching between control and monitor states. The black dot indicates the initial transition. Once in the monitor state, the ControlStation can...is to develop a UML profile. UML profiles are analogous to spoken language dialects. For example, Cajun is a dialect of North American English...UML_AADL_Comparison.pdf. 49. Grady Booch, “Software Architecture, Software Engineering, and Renaissance Jazz , Microsoft and Domain Specific Languages,” December 2004

  9. Performance Evaluation of UML2-Modeled Embedded Streaming Applications with System-Level Simulation

    Directory of Open Access Journals (Sweden)

    Arpinen Tero

    2009-01-01

    Full Text Available This article presents an efficient method to capture abstract performance model of streaming data real-time embedded systems (RTESs. Unified Modeling Language version 2 (UML2 is used for the performance modeling and as a front-end for a tool framework that enables simulation-based performance evaluation and design-space exploration. The adopted application meta-model in UML resembles the Kahn Process Network (KPN model and it is targeted at simulation-based performance evaluation. The application workload modeling is done using UML2 activity diagrams, and platform is described with structural UML2 diagrams and model elements. These concepts are defined using a subset of the profile for Modeling and Analysis of Realtime and Embedded (MARTE systems from OMG and custom stereotype extensions. The goal of the performance modeling and simulation is to achieve early estimates on task response times, processing element, memory, and on-chip network utilizations, among other information that is used for design-space exploration. As a case study, a video codec application on multiple processors is modeled, evaluated, and explored. In comparison to related work, this is the first proposal that defines transformation between UML activity diagrams and streaming data application workload meta models and successfully adopts it for RTES performance evaluation.

  10. Prototype of Intrusion Detection Model using UML 5.0 and Forward Engineering

    Directory of Open Access Journals (Sweden)

    Muthaiyan MADIAJAGAN,

    2011-01-01

    Full Text Available In this paper we are using UML (Unified Modeling Language which is the blueprint language between the programmers, analysts, and designer’s for easy representation of pictures or diagrammatic notation with some textual data. Here we are using UML 5.0 to show “prototype of the Intrusion Detection Model” and by explaining it by combining various parts by drawing various UML diagrams such as Use cases and Activity diagrams and Class Diagram using which we show forward engineering using the class diagram of the IDM( Intrusion Detection Model. IDM is a device or software that works on detecting malicious activities by unauthorized users that can cause breach to the security policy within a network.

  11. Transforming Functional Requirements from UML into BPEL to Efficiently Develop SOA-Based Systems

    Science.gov (United States)

    Vemulapalli, Anisha; Subramanian, Nary

    The intended behavior of any system such as services, tasks or functions can be captured by functional requirements of the system. As our dependence on online services has grown steadily, the web applications are being developed employing the SOA. BPEL4WS provides a means for expressing functional requirements of an SOA-based system by providing constructs to capture business goals and objectives for the system. In this paper we propose an approach for transforming user-centered requirements captured using UML into a corresponding BPEL specification, where the business processes are captured by means of use-cases from which UML sequence diagrams and activity diagrams are extracted. Subsequently these UML models are mapped to BPEL specifications that capture the essence of the initial business requirements to develop the SOA-based system by employing CASE tools. A student housing system is used as a case study to illustrate this approach and the system is validated using NetBeans.

  12. Analyzing polysemous concepts from a clinical perspective: Application to auditing concept categorization in the UMLS

    Science.gov (United States)

    Mougin, Fleur; Bodenreider, Olivier; Burgun, Anita

    2015-01-01

    Objectives Polysemy is a frequent issue in biomedical terminologies. In the Unified Medical Language System (UMLS), polysemous terms are either represented as several independent concepts, or clustered into a single, multiply-categorized concept. The objective of this study is to analyze polysemous concepts in the UMLS through their categorization and hierarchical relations for auditing purposes. Methods We used the association of a concept with multiple Semantic Groups (SGs) as a surrogate for polysemy. We first extracted multi-SG (MSG) concepts from the UMLS Metathesaurus and characterized them in terms of the combinations of SGs with which they are associated. We then clustered MSG concepts in order to identify major types of polysemy. We also analyzed the inheritance of SGs in MSG concepts. Finally, we manually reviewed the categorization of the MSG concepts for auditing purposes. Results The 1208 MSG concepts in the Metathesaurus are associated with 30 distinct pairs of SGs. We created 75 semantically homogeneous clusters of MSG concepts, and 276 MSG concepts could not be clustered for lack of hierarchical relations. The clusters were characterized by the most frequent pairs of semantic types of their constituent MSG concepts. MSG concepts exhibit limited semantic compatibility with their parent and child concepts. A large majority of MSG concepts (92%) are adequately categorized. Examples of miscategorized concepts are presented. Conclusion This work is a systematic analysis and manual review of all concepts categorized by multiple SGs in the UMLS. The correctly-categorized MSG concepts do reflect polysemy in the UMLS Metathesaurus. The analysis of inheritance of SGs proved useful for auditing concept categorization in the UMLS. PMID:19303057

  13. Arranging ISO 13606 archetypes into a knowledge base using UML connectors.

    Science.gov (United States)

    Kopanitsa, Georgy

    2014-01-01

    To enable the efficient reuse of standard based medical data we propose to develop a higher-level information model that will complement the archetype model of ISO 13606. This model will make use of the relationships that are specified in UML to connect medical archetypes into a knowledge base within a repository. UML connectors were analysed for their ability to be applied in the implementation of a higher-level model that will establish relationships between archetypes. An information model was developed using XML Schema notation. The model allows linking different archetypes of one repository into a knowledge base. Presently it supports several relationships and will be advanced in future.

  14. A rule-based approach to model checking of UML state machines

    Science.gov (United States)

    Grobelna, Iwona; Grobelny, Michał; Stefanowicz, Łukasz

    2016-12-01

    In the paper a new approach to formal verification of control process specification expressed by means of UML state machines in version 2.x is proposed. In contrast to other approaches from the literature, we use the abstract and universal rule-based logical model suitable both for model checking (using the nuXmv model checker), but also for logical synthesis in form of rapid prototyping. Hence, a prototype implementation in hardware description language VHDL can be obtained that fully reflects the primary, already formally verified specification in form of UML state machines. Presented approach allows to increase the assurance that implemented system meets the user-defined requirements.

  15. Transformación de las restricciones OCL de un esquema UML a consultas de SQL

    OpenAIRE

    Casillas Cortázar, Sergio

    2012-01-01

    En la actualidad existen muchos métodos y herramientas que permiten la generación automática y completa del código de una aplicación a partir de un diagrama en UML. El lenguaje UML (Unified Modeling Language, Lenguaje Unificado de Modelado) es un lenguaje visual cuyo uso más extendido es documentar, construir y especificar los modelos del sistema. Todas estas herramientas son capaces de generar clases en Java o tablas en un Sistema de Gestión de Bases de Datos (DBMS, DataBase Management Sy...

  16. On the Impact of Layout Quality to Understanding UML Diagrams: Diagram Type and Expertise

    DEFF Research Database (Denmark)

    Störrle, Harald

    2012-01-01

    Practical experience suggests that the use and understanding of UML diagrams is greatly affected by the quality of their layout. In previous work, we have presented evidence supporting this intuition. This contrasts with earlier experiments that yielded weak or inconclusive evidence only. In the ......Practical experience suggests that the use and understanding of UML diagrams is greatly affected by the quality of their layout. In previous work, we have presented evidence supporting this intuition. This contrasts with earlier experiments that yielded weak or inconclusive evidence only...

  17. Designing Tool Support for Translating Use Cases and UML 2.0 Sequence Diagrams into a Coloured Petri Net

    DEFF Research Database (Denmark)

    Fernandes, Joao Miguel; Tjell, Simon; Jørgensen, Jens Bæk

    2007-01-01

    On a case study on the specification of an elevator controller, this paper presents an approach that can translate given UML descriptions into a Coloured Petri Net (CPN) model. The UML descriptions must be specified in the form of Use Cases (UCs) and UML 2.0 Sequence Diagrams (SDs). The CPN model...... constitutes one single, coherent and executable representation of all possible behaviours that are specified by the given UML artefacts. CPN is a formal modelling language that enables construction and analysis of scalable, executable models of behaviour. A combined use of UML and CPN can be useful in several...... projects. CPN is well supported by the tool called CPN Tools and the work we present here is aimed at building a CPN Tools front-end engine that implements the proposed translation....

  18. Una extensión de UML para el modelado de servicios Web

    Directory of Open Access Journals (Sweden)

    Esperanza Marcos M.

    2004-01-01

    Full Text Available Los servicios Web han surgido para proveer un marco basado en estándares, que permite la interacción de aplicaciones a través de la Web. A pesar de que existen varias tecnologías que facilitan el desarrollo de servicios Web y aplicaciones orientadas a servicios, la carencia de una base metodológica sólida para el desarrollo de tales aplicaciones, plantea la necesidad de nuevos métodos o técnicas de modelado que puedan garantizar la calidad en el desarrollo de este tipo de aplicaciones. MIDAS es un marco metodológico orientado a modelos para el desarrollo de SIWs, que está basado en UML, XML y tecnología objetorelacional y que propone el modelado del comportamiento del sistema basado en servicios Web. En este artículo se presenta una extensión de UML para el modelado de servicios Web, basada en el estándar Web Service Description Language (WSDL propuesto por el W3C para la descripción de servicios Web. La extensión propuesta aporta una notación en UML que, por un lado, permite obtener una representación gráfica de un servicio Web y por otro, facilitará la generación automática de código WSDL a partir de un diagrama UML.

  19. The Neighborhood Auditing Tool: a hybrid interface for auditing the UMLS.

    Science.gov (United States)

    Morrey, C Paul; Geller, James; Halper, Michael; Perl, Yehoshua

    2009-06-01

    The UMLS's integration of more than 100 source vocabularies, not necessarily consistent with one another, causes some inconsistencies. The purpose of auditing the UMLS is to detect such inconsistencies and to suggest how to resolve them while observing the requirement of fully representing the content of each source in the UMLS. A software tool, called the Neighborhood Auditing Tool (NAT), that facilitates UMLS auditing is presented. The NAT supports "neighborhood-based" auditing, where, at any given time, an auditor concentrates on a single-focus concept and one of a variety of neighborhoods of its closely related concepts. Typical diagrammatic displays of concept networks have a number of shortcomings, so the NAT utilizes a hybrid diagram/text interface that features stylized neighborhood views which retain some of the best features of both the diagrammatic layouts and text windows while avoiding the shortcomings. The NAT allows an auditor to display knowledge from both the Metathesaurus (concept) level and the Semantic Network (semantic type) level. Various additional features of the NAT that support the auditing process are described. The usefulness of the NAT is demonstrated through a group of case studies. Its impact is tested with a study involving a select group of auditors.

  20. A UML profile for code generation of component based distributed systems

    International Nuclear Information System (INIS)

    Chiozzi, G.; Karban, R.; Andolfato, L.; Tejeda, A.

    2012-01-01

    A consistent and unambiguous implementation of code generation (model to text transformation) from UML (must rely on a well defined UML (Unified Modelling Language) profile, customizing UML for a particular application domain. Such a profile must have a solid foundation in a formally correct ontology, formalizing the concepts and their relations in the specific domain, in order to avoid a maze or set of wildly created stereotypes. The paper describes a generic profile for the code generation of component based distributed systems for control applications, the process to distill the ontology and define the profile, and the strategy followed to implement the code generator. The main steps that take place iteratively include: defining the terms and relations with an ontology, mapping the ontology to the appropriate UML meta-classes, testing the profile by creating modelling examples, and generating the code. This has allowed us to work on the modelling of E-ELT (European Extremely Large Telescope) control system and instrumentation without knowing what infrastructure will be finally used

  1. On the Impact of Layout Quality to Understanding UML Diagrams: Size Matters

    DEFF Research Database (Denmark)

    Störrle, Harald

    2014-01-01

    Practical experience suggests that usage and understanding of UML diagrams is greatly affected by the quality of their layout. While existing research failed to provide conclusive evidence in support of this hypothesis, our own previous work provided substantial evidence to this effect. When...

  2. XML View, Part III: An UML Based Design Methodology for XML Views

    NARCIS (Netherlands)

    Rajugan, R.; Dillon, T.S.; Chang, E.; Feng, L.

    Object-Oriented (OO) conceptual models have the power in describing and modelling real-world data semantics and their inter-relationships in a form that is precise and comprehensible to users. Today UML has established itself as the language of choice for modelling complex enterprises information

  3. On the impact of size to the understanding of UML diagrams

    DEFF Research Database (Denmark)

    Störrle, Harald

    2016-01-01

    Background: Practical experience suggests that usage and understanding of UML diagrams is greatly affected by the quality of their layout. While existing research failed to provide conclusive and comprehensive evidence in support of this hypothesis, our own previous work provided substantial evid...

  4. From use cases to UML class diagrams using logic grammars and constraints

    DEFF Research Database (Denmark)

    Christiansen, Henning; Have, Christian Theil; Tveitane, Knut

    2007-01-01

    We investigate the possibilities for automated transition from Use Cases in a restricted natural language syntax into UML class diagrams, by trying to capture the semantics of the natural language and map it into building blocks of the object oriented programming paradigm (classes, objects, methods...

  5. Towards refactoring the Molecular Function Ontology with a UML profile for function modeling.

    Science.gov (United States)

    Burek, Patryk; Loebe, Frank; Herre, Heinrich

    2017-10-04

    Gene Ontology (GO) is the largest resource for cataloging gene products. This resource grows steadily and, naturally, this growth raises issues regarding the structure of the ontology. Moreover, modeling and refactoring large ontologies such as GO is generally far from being simple, as a whole as well as when focusing on certain aspects or fragments. It seems that human-friendly graphical modeling languages such as the Unified Modeling Language (UML) could be helpful in connection with these tasks. We investigate the use of UML for making the structural organization of the Molecular Function Ontology (MFO), a sub-ontology of GO, more explicit. More precisely, we present a UML dialect, called the Function Modeling Language (FueL), which is suited for capturing functions in an ontologically founded way. FueL is equipped, among other features, with language elements that arise from studying patterns of subsumption between functions. We show how to use this UML dialect for capturing the structure of molecular functions. Furthermore, we propose and discuss some refactoring options concerning fragments of MFO. FueL enables the systematic, graphical representation of functions and their interrelations, including making information explicit that is currently either implicit in MFO or is mainly captured in textual descriptions. Moreover, the considered subsumption patterns lend themselves to the methodical analysis of refactoring options with respect to MFO. On this basis we argue that the approach can increase the comprehensibility of the structure of MFO for humans and can support communication, for example, during revision and further development.

  6. Diagram, a Learning Environment for Initiation to Object-Oriented Modeling with UML Class Diagrams

    Science.gov (United States)

    Py, Dominique; Auxepaules, Ludovic; Alonso, Mathilde

    2013-01-01

    This paper presents Diagram, a learning environment for object-oriented modelling (OOM) with UML class diagrams. Diagram an open environment, in which the teacher can add new exercises without constraints on the vocabulary or the size of the diagram. The interface includes methodological help, encourages self-correcting and self-monitoring, and…

  7. Augmenting Oracle Text with the UMLS for enhanced searching of free-text medical reports.

    Science.gov (United States)

    Ding, Jing; Erdal, Selnur; Dhaval, Rakesh; Kamal, Jyoti

    2007-10-11

    The intrinsic complexity of free-text medical reports imposes great challenges for information retrieval systems. We have developed a prototype search engine for retrieving clinical reports that leverages the powerful indexing and querying capabilities of Oracle Text, and the rich biomedical domain knowledge and semantic structures that are captured in the UMLS Metathesaurus.

  8. Alignment of the UMLS semantic network with BioTop: Methodology and assessment

    NARCIS (Netherlands)

    S. Schulz; E. Beisswanger (Elena); L. van den Hoek (László); O. Bodenreider (Olivier); E.M. van Mulligen (Erik)

    2009-01-01

    textabstractMotivation: For many years, the Unified Medical Language System (UMLS) semantic network (SN) has been used as an upper-level semantic framework for the categorization of terms from terminological resources in biomedicine. BioTop has recently been developed as an upper-level ontology for

  9. "UML Quiz": Automatic Conversion of Web-Based E-Learning Content in Mobile Applications

    Science.gov (United States)

    von Franqué, Alexander; Tellioglu, Hilda

    2014-01-01

    Many educational institutions use Learning Management Systems to provide e-learning content to their students. This often includes quizzes that can help students to prepare for exams. However, the content is usually web-optimized and not very usable on mobile devices. In this work a native mobile application ("UML Quiz") that imports…

  10. Using UML and Petri nets for visualization of business document flow

    Directory of Open Access Journals (Sweden)

    Ivana Rábová

    2012-01-01

    Full Text Available The article deals with two principles of business workflow modeling, Petri nets and UML notation, that are the acceptable approaches to business modeling and can be used also for business documents workflow. The special type of Petri nets, WF-nets and UML activity diagrams are used in this article and both modeling ways are presented on the concrete business workflow and then there are presented and specified their advantage and disadvantage for business documents flows. At beginning it is explained the word workflow in context business documents, its features, principles and using in business environment. After that it is clarified that the UML is OMG’s most-used specification, and the way the world models not only application structure, behavior, and architecture, but also business process, workflows and data structure. Activity diagram UML is good way to show how different workflows in the business are managed, how they start, go and stop. Diagrams also show many different decision paths that can be taken from start to finish. State charts can be used as a detail the transitions or changes of states when documents can go through in the business. They show how a documents moves from one state to another and the rules that govern that change. Petri-nets offer a graphical notation for stepwise processes that include choice, iteration, and concurrent execution. Unlike UML Petri nets have an exact mathematical definition of their execution semantics, with a well-developed mathematical theory for process analysis. In the article there are modeled a special type of Petri nets, the WF-nets. The practical part of article incorporates two models of concrete business documents workflows presented in these notations, their comparison and recommendation for using these diagrams in business process management.

  11. Contribution to the building of an execution engine for UML models for the simulation of competitor and timed applications

    International Nuclear Information System (INIS)

    Benyahia, A.

    2012-01-01

    Model Driven Engineering (MDE) places models at the heart of the software engineering process. MDE helps managing the complexity of software systems and improving the quality of the development process. The Model Driven Architecture (MDA) initiative from the Object Management Group (OMG) defines a framework for building design flows in the context of MDE. MDA relies heavily on formalisms which are normalized by the OMG, such as UML for modeling, QVT for model transformations and so on. This work deals with the execution semantics of the UML language applied to embedded real-time applications. In this context, the OMG has a norm which defines an execution model for a subset of UML called fUML (foundational UML subset). This execution model gives a precise semantics to UML models, which can be used for analyzing models, generating code, or verifying transformations. The goal of this PhD thesis is to define and build an execution engine for UML models of embedded real-time systems, which takes into account the explicit hypothesis made by the designer about the execution semantics at a high level of abstraction, in order to be able to execute models as early as possible in the design flow of a system. To achieve this goal, we have extended the fUML execution model along three important axes with regard to embedded real-time systems: - Concurrence: fUML does not provide any mechanism for handling concurrent activities in its execution engine. We address this issue by introducing an explicit scheduler which allows us to control the execution of concurrent tasks. - Time: fUML does not provide any mean to handle time. By adding a clock to the model of execution, we can take into account the elapsed time as well as temporal constraints on the execution of activities. - Profiles: fUML does not take profiles into account, which makes it difficult to personalize the execution engine with new semantic variants. The execution engine we propose allows the use of UML models with

  12. Structural Group-based Auditing of Missing Hierarchical Relationships in UMLS

    Science.gov (United States)

    Chen, Yan; Gu, Huanying(Helen); Perl, Yehoshua; Geller, James

    2009-01-01

    The Metathesaurus of the UMLS was created by integrating various source terminologies. The inter-concept relationships were either integrated into the UMLS from the source terminologies or specially generated. Due to the extensive size and inherent complexity of the Metathesaurus, the accidental omission of some hierarchical relationships was inevitable. We present a recursive procedure which allows a human expert, with the support of an algorithm, to locate missing hierarchical relationships. The procedure starts with a group of concepts with exactly the same (correct) semantic type assignments. It then partitions the concepts, based on child-of hierarchical relationships, into smaller, singly rooted, hierarchically connected subgroups. The auditor only needs to focus on the subgroups with very few concepts and their concepts with semantic type reassignments. The procedure was evaluated by comparing it with a comprehensive manual audit and it exhibits a perfect error recall. PMID:18824248

  13. The UMLS Knowledge Source Server: an experience in Web 2.0 technologies.

    Science.gov (United States)

    Thorn, Karen E; Bangalore, Anantha K; Browne, Allen C

    2007-10-11

    The UMLS Knowledge Source Server (UMLSKS), developed at the National Library of Medicine (NLM), makes the knowledge sources of the Unified Medical Language System (UMLS) available to the research community over the Internet. In 2003, the UMLSKS was redesigned utilizing state-of-the-art technologies available at that time. That design offered a significant improvement over the prior version but presented a set of technology-dependent issues that limited its functionality and usability. Four areas of desired improvement were identified: software interfaces, web interface content, system maintenance/deployment, and user authentication. By employing next generation web technologies, newer authentication paradigms and further refinements in modular design methods, these areas could be addressed and corrected to meet the ever increasing needs of UMLSKS developers. In this paper we detail the issues present with the existing system and describe the new system's design using new technologies considered entrants in the Web 2.0 development era.

  14. Path generation algorithm for UML graphic modeling of aerospace test software

    Science.gov (United States)

    Qu, MingCheng; Wu, XiangHu; Tao, YongChao; Chen, Chao

    2018-03-01

    Aerospace traditional software testing engineers are based on their own work experience and communication with software development personnel to complete the description of the test software, manual writing test cases, time-consuming, inefficient, loopholes and more. Using the high reliability MBT tools developed by our company, the one-time modeling can automatically generate test case documents, which is efficient and accurate. UML model to describe the process accurately express the need to rely on the path is reached, the existing path generation algorithm are too simple, cannot be combined into a path and branch path with loop, or too cumbersome, too complicated arrangement generates a path is meaningless, for aerospace software testing is superfluous, I rely on our experience of ten load space, tailor developed a description of aerospace software UML graphics path generation algorithm.

  15. UML-based testcase- and system model for railway process control- and safety engineering; UML-basierte Testfall- und Systemmodelle fuer die Eisenbahnleit- und -sicherungstechnik

    Energy Technology Data Exchange (ETDEWEB)

    Knollmann, V.

    2007-12-15

    The continuous introduction of more sophisticated and more complex automation systems is of high relevance for operations- and control devices for railway applications. One example of this trend is the European Train Control System (ETCS). I is harmonized for all European member states and currently deployed for commercial use on selected lines. Applications like ETCS take responsibility for passengers, environment and the rolling stock material. For this reason, the development of those applications is characterized by high demands on testing, documentation and quality assurance. Unfortunately, real projects have proven to achieve these high demands only with tremendous efforts as long as they stick to their traditional development processes and methods. Therefore, a wide spread exploration for new concepts regarding planning, implementation and - most of all - testing of safety relevant systems is under its way. This thesis contributes to the search for new design methods for such systems. It combines recent achievements in the environment of the Unified Modeling Language (UML) to an integrated approach for a consistent testcase- and system description in a single UML model. The model comprises the UML profiles SysML (System Modeling Language) and U2TP (UML 2 Testing Profile), which are officially specified and released by the Object Management Group (OMG). This thesis shows how based on these two profiles - a single, combined system- and testcase model can be build - relationships between requirements, implementation- and testcase can be established - requirement relationships can be evaluated automatically to ensure model consistency and to determine implementation and testcase coverage - C++-code can be generated directly from the model - TTCN-3-code (Testing and Test Control Notation, Version 3) can be derived automatically from the model - a toolchain can be set up which supports all mentioned functions. In order to prove the feasibility of this approach, a

  16. Suggest an Aspect-Oriented Design Approach for UML Communication Diagram

    OpenAIRE

    Nather, Mohammed F.; Saleem, Dr. Nada N.

    2013-01-01

    More and more works are done on the design of the Unified Modeling Language (UML) which is designed to help us for modeling effective object oriented software, Existing Object-Oriented design methods are not mature enough to capture non-functional requirement such as concurrency, fault tolerance, distribution and persistence of a software approach. Our approach proposed to use aspect-oriented software development (AOSD) mechanisms to solve the issues for interactions of the communication diag...

  17. Relating UMLS semantic types and task-based ontology to computer-interpretable clinical practice guidelines.

    Science.gov (United States)

    Kumar, Anand; Ciccarese, Paolo; Quaglini, Silvana; Stefanelli, Mario; Caffi, Ezio; Boiocchi, Lorenzo

    2003-01-01

    Medical knowledge in clinical practice guideline (GL) texts is the source of task-based computer-interpretable clinical guideline models (CIGMs). We have used Unified Medical Language System (UMLS) semantic types (STs) to understand the percentage of GL text which belongs to a particular ST. We also use UMLS semantic network together with the CIGM-specific ontology to derive a semantic meaning behind the GL text. In order to achieve this objective, we took nine GL texts from the National Guideline Clearinghouse (NGC) and marked up the text dealing with a particular ST. The STs we took into consideration were restricted taking into account the requirements of a task-based CIGM. We used DARPA Agent Markup Language and Ontology Inference Layer (DAML + OIL) to create the UMLS and CIGM specific semantic network. For the latter, as a bench test, we used the 1999 WHO-International Society of Hypertension Guidelines for the Management of Hypertension. We took into consideration the UMLS STs closest to the clinical tasks. The percentage of the GL text dealing with the ST "Health Care Activity" and subtypes "Laboratory Procedure", "Diagnostic Procedure" and "Therapeutic or Preventive Procedure" were measured. The parts of text belonging to other STs or comments were separated. A mapping of terms belonging to other STs was done to the STs under "HCA" for representation in DAML + OIL. As a result, we found that the three STs under "HCA" were the predominant STs present in the GL text. In cases where the terms of related STs existed, they were mapped into one of the three STs. The DAML + OIL representation was able to describe the hierarchy in task-based CIGMs. To conclude, we understood that the three STs could be used to represent the semantic network of the task-bases CIGMs. We identified some mapping operators which could be used for the mapping of other STs into these.

  18. A collaborative knowledge management framework for supply chains: A UML-based model approach

    Directory of Open Access Journals (Sweden)

    Jorge Esteban Hernández

    2008-12-01

    Full Text Available In the most general cases, collaborative activities imply a distributed decision-making process which involves several supply chain nodes. In this paper, by means of a literature review, and by also considering the deficiencies of existing proposals, a collaborative knowledge management UML-based framework supported is proposed. In addition, this proposal synthesizes existing knowledge, and it not only fulfils, but enriches, each component with the modeller’s own knowledge.

  19. Alignment of the UMLS semantic network with BioTop: methodology and assessment.

    Science.gov (United States)

    Schulz, Stefan; Beisswanger, Elena; van den Hoek, László; Bodenreider, Olivier; van Mulligen, Erik M

    2009-06-15

    For many years, the Unified Medical Language System (UMLS) semantic network (SN) has been used as an upper-level semantic framework for the categorization of terms from terminological resources in biomedicine. BioTop has recently been developed as an upper-level ontology for the biomedical domain. In contrast to the SN, it is founded upon strict ontological principles, using OWL DL as a formal representation language, which has become standard in the semantic Web. In order to make logic-based reasoning available for the resources annotated or categorized with the SN, a mapping ontology was developed aligning the SN with BioTop. The theoretical foundations and the practical realization of the alignment are being described, with a focus on the design decisions taken, the problems encountered and the adaptations of BioTop that became necessary. For evaluation purposes, UMLS concept pairs obtained from MEDLINE abstracts by a named entity recognition system were tested for possible semantic relationships. Furthermore, all semantic-type combinations that occur in the UMLS Metathesaurus were checked for satisfiability. The effort-intensive alignment process required major design changes and enhancements of BioTop and brought up several design errors that could be fixed. A comparison between a human curator and the ontology yielded only a low agreement. Ontology reasoning was also used to successfully identify 133 inconsistent semantic-type combinations. BioTop, the OWL DL representation of the UMLS SN, and the mapping ontology are available at http://www.purl.org/biotop/.

  20. Design and implementation of the system of importing data of nuclear analysis experiment based on UML technology

    International Nuclear Information System (INIS)

    Peng Yanguang; Yu Chuansong; Ma Mei; Sun Gongxing

    2004-01-01

    There are some problems that Excel data importing to database for our scientific data processing, we introduce a method how to use UML and XML technology design and implementation our system. Because XML technology have flexible data exchange mechanism, so it is appropriate to do it, and it is easy for use that the system of importing data of nuclear analysis experiment has a web browser GUI. Our paper emphasis on the software design method and UML design cases. (authors)

  1. Analýza a návrh aplikace s využitím UML

    OpenAIRE

    Hajník, Julius

    2009-01-01

    The goal of this work is to create an example of analysis and design of computer application utilizing the notation of UML usable for purposes of education in elementary informatics classes. Analysis and design are demonstrated on application Distributor SW. This application serves for recording purchase orders in software retail business. astah* is the CASE tool used in this work for modeling with UML notation.

  2. UN PATRÓN DE INTERACCIÓN ENTRE DIAGRAMAS DE ACTIVIDADES UML Y SISTEMAS WORKFLOW AN INTERACTION PATTERN BETWEEN UML ACTIVITY DIAGRAMS AND WORKFLOW SYSTEMS

    Directory of Open Access Journals (Sweden)

    Marta Silvia Tabares

    2008-12-01

    Full Text Available Actualmente en los ambientes de desarrollo de software hay un gran interés en buscar y desarrollar técnicas que puedan integrar los sistemas transaccionales con los flujos de trabajo que soportan los procesos del negocio de las organizaciones. Sin embargo, en la industria del software no es común encontrar técnicas o prácticas que faciliten el desarrollo de los modelos del sistema en función de los procesos del negocio. En este artículo se define un patrón de desarrollo que estandariza la interacción entre diagramas de actividades de UML 2.0, que representan las operaciones de un sistema, y procesos del negocio automatizados bajo tecnologías workflow. La trazabilidad de dicha interacción se mantiene por medio de modelos de trazabilidad que controlan la evolución de las operaciones del negocio y del sistema. Para mostrar la aplicación del patrón se desarrolla un caso de estudioIn software development environments there is a big interest to look and develop techniques that could integrate transactional systems with Workflow systems in order to support the business processes in organizations Nevertheless, in the software industry it is not common to find techniques or practices that facilitate the development of system models according to the business processes. In this article we define a development pattern to standardize the interaction between UML 2.0 activity diagrams, which represent the operations of a system, and the business processes automated by means of Workflow technologies. The traceability of the above mentioned interaction is supported by means of traceability models that control the evolution of both operations of the business and of the system. To show the application of the pattern a case study is developed.

  3. Analysis and design of hospital management information system based on UML

    Science.gov (United States)

    Ma, Lin; Zhao, Huifang; You, Shi Jun; Ge, Wenyong

    2018-05-01

    With the rapid development of computer technology, computer information management system has been utilized in many industries. Hospital Information System (HIS) is in favor of providing data for directors, lightening the workload for the medical workers, and improving the workers efficiency. According to the HIS demand analysis and system design, this paper focus on utilizing unified modeling language (UML) models to establish the use case diagram, class diagram, sequence chart and collaboration diagram, and satisfying the demands of the daily patient visit, inpatient, drug management and other relevant operations. At last, the paper summarizes the problems of the system and puts forward an outlook of the HIS system.

  4. A UMLS-based spell checker for natural language processing in vaccine safety

    Directory of Open Access Journals (Sweden)

    Liu Fang

    2007-02-01

    Full Text Available Abstract Background The Institute of Medicine has identified patient safety as a key goal for health care in the United States. Detecting vaccine adverse events is an important public health activity that contributes to patient safety. Reports about adverse events following immunization (AEFI from surveillance systems contain free-text components that can be analyzed using natural language processing. To extract Unified Medical Language System (UMLS concepts from free text and classify AEFI reports based on concepts they contain, we first needed to clean the text by expanding abbreviations and shortcuts and correcting spelling errors. Our objective in this paper was to create a UMLS-based spelling error correction tool as a first step in the natural language processing (NLP pipeline for AEFI reports. Methods We developed spell checking algorithms using open source tools. We used de-identified AEFI surveillance reports to create free-text data sets for analysis. After expansion of abbreviated clinical terms and shortcuts, we performed spelling correction in four steps: (1 error detection, (2 word list generation, (3 word list disambiguation and (4 error correction. We then measured the performance of the resulting spell checker by comparing it to manual correction. Results We used 12,056 words to train the spell checker and tested its performance on 8,131 words. During testing, sensitivity, specificity, and positive predictive value (PPV for the spell checker were 74% (95% CI: 74–75, 100% (95% CI: 100–100, and 47% (95% CI: 46%–48%, respectively. Conclusion We created a prototype spell checker that can be used to process AEFI reports. We used the UMLS Specialist Lexicon as the primary source of dictionary terms and the WordNet lexicon as a secondary source. We used the UMLS as a domain-specific source of dictionary terms to compare potentially misspelled words in the corpus. The prototype sensitivity was comparable to currently available

  5. Communicating systems with UML 2 modeling and analysis of network protocols

    CERN Document Server

    Barrera, David Garduno

    2013-01-01

    This book gives a practical approach to modeling and analyzing communication protocols using UML 2. Network protocols are always presented with a point of view focusing on partial mechanisms and starting models. This book aims at giving the basis needed for anybody to model and validate their own protocols. It follows a practical approach and gives many examples for the description and analysis of well known basic network mechanisms for protocols.The book firstly shows how to describe and validate the main protocol issues (such as synchronization problems, client-server interactions, layer

  6. Towards an automatic model transformation mechanism from UML state machines to DEVS models

    Directory of Open Access Journals (Sweden)

    Ariel González

    2015-08-01

    Full Text Available The development of complex event-driven systems requires studies and analysis prior to deployment with the goal of detecting unwanted behavior. UML is a language widely used by the software engineering community for modeling these systems through state machines, among other mechanisms. Currently, these models do not have appropriate execution and simulation tools to analyze the real behavior of systems. Existing tools do not provide appropriate libraries (sampling from a probability distribution, plotting, etc. both to build and to analyze models. Modeling and simulation for design and prototyping of systems are widely used techniques to predict, investigate and compare the performance of systems. In particular, the Discrete Event System Specification (DEVS formalism separates the modeling and simulation; there are several tools available on the market that run and collect information from DEVS models. This paper proposes a model transformation mechanism from UML state machines to DEVS models in the Model-Driven Development (MDD context, through the declarative QVT Relations language, in order to perform simulations using tools, such as PowerDEVS. A mechanism to validate the transformation is proposed. Moreover, examples of application to analyze the behavior of an automatic banking machine and a control system of an elevator are presented.

  7. The architecture of the CMS Level-1 Trigger Control and Monitoring System using UML

    International Nuclear Information System (INIS)

    Magrans de Abril, Marc; Ghabrous Larrea, Carlos; Lazaridis, Christos; Da Rocha Melo, Jose L; Hammer, Josef; Hartl, Christian

    2011-01-01

    The architecture of the Compact Muon Solenoid (CMS) Level-1 Trigger Control and Monitoring software system is presented. This system has been installed and commissioned on the trigger online computers and is currently used for data taking. It has been designed to handle the trigger configuration and monitoring during data taking as well as all communications with the main run control of CMS. Furthermore its design has foreseen the provision of the software infrastructure for detailed testing of the trigger system during beam down time. This is a medium-size distributed system that runs over 40 PCs and 200 processes that control about 4000 electronic boards. The architecture of this system is described using the industry-standard Universal Modeling Language (UML). This way the relationships between the different subcomponents of the system become clear and all software upgrades and modifications are simplified. The described architecture has allowed for frequent upgrades that were necessary during the commissioning phase of CMS when the trigger system evolved constantly. As a secondary objective, the paper provides a UML usage example and tries to encourage the standardization of the software documentation of large projects across the LHC and High Energy Physics community.

  8. Refinamiento del diagrama de clases UML a Oracle®9I en ATOM3

    Directory of Open Access Journals (Sweden)

    CARLOS M. ZAPATA

    2007-01-01

    Full Text Available El OMG define el refinamiento como el proceso de transformación desde un modelo independiente de la plataforma de implementación hacia un modelo específico de la plataforma de implementación. Las herramientas CASE convencionales han experimentado problemas con este tipo de transformación, debido a la definición estática de los modelos incluidos en ellas, a las dificultades para la definición de reglas de transformación y al pobre rendimiento mostrado por ellas en la obtención de código. Las herramientas MetaCASE han surgido con nuevas capacidades para mejorar el refinamiento en el contexto de la transformación entre modelos. En este artículo se presenta una implementación en AToM3 para refinamiento que transforma un diagrama de clases UML independiente de la plataforma de implementación a un diagrama de clases UML dependiente de la plataforma de implementación Oracle® 9i. Además, se muestra el uso de esta clase de refinamiento con un caso de estudio.

  9. The architecture of the CMS Level-1 Trigger Control and Monitoring System using UML

    Science.gov (United States)

    Magrans de Abril, Marc; Da Rocha Melo, Jose L.; Ghabrous Larrea, Carlos; Hammer, Josef; Hartl, Christian; Lazaridis, Christos

    2011-12-01

    The architecture of the Compact Muon Solenoid (CMS) Level-1 Trigger Control and Monitoring software system is presented. This system has been installed and commissioned on the trigger online computers and is currently used for data taking. It has been designed to handle the trigger configuration and monitoring during data taking as well as all communications with the main run control of CMS. Furthermore its design has foreseen the provision of the software infrastructure for detailed testing of the trigger system during beam down time. This is a medium-size distributed system that runs over 40 PCs and 200 processes that control about 4000 electronic boards. The architecture of this system is described using the industry-standard Universal Modeling Language (UML). This way the relationships between the different subcomponents of the system become clear and all software upgrades and modifications are simplified. The described architecture has allowed for frequent upgrades that were necessary during the commissioning phase of CMS when the trigger system evolved constantly. As a secondary objective, the paper provides a UML usage example and tries to encourage the standardization of the software documentation of large projects across the LHC and High Energy Physics community.

  10. Comparison of BrainTool to other UML modeling and model transformation tools

    Science.gov (United States)

    Nikiforova, Oksana; Gusarovs, Konstantins

    2017-07-01

    In the last 30 years there were numerous model generated software systems offered targeting problems with the development productivity and the resulting software quality. CASE tools developed due today's date are being advertised as having "complete code-generation capabilities". Nowadays the Object Management Group (OMG) is calling similar arguments in regards to the Unified Modeling Language (UML) models at different levels of abstraction. It is being said that software development automation using CASE tools enables significant level of automation. Actual today's CASE tools are usually offering a combination of several features starting with a model editor and a model repository for a traditional ones and ending with code generator (that could be using a scripting or domain-specific (DSL) language), transformation tool to produce the new artifacts from the manually created and transformation definition editor to define new transformations for the most advanced ones. Present paper contains the results of CASE tool (mainly UML editors) comparison against the level of the automation they are offering.

  11. Colaborated Architechture Framework for Composition UML 2.0 in Zachman Framework

    Science.gov (United States)

    Hermawan; Hastarista, Fika

    2016-01-01

    Zachman Framework (ZF) is the framework of enterprise architechture that most widely adopted in the Enterprise Information System (EIS) development. In this study, has been developed Colaborated Architechture Framework (CAF) to collaborate ZF with Unified Modeling Language (UML) 2.0 modeling. The CAF provides the composition of ZF matrix that each cell is consist of the Model Driven architechture (MDA) from the various UML models and many Software Requirement Specification (SRS) documents. Implementation of this modeling is used to develops Enterprise Resource Planning (ERP). Because ERP have a coverage of applications in large numbers and complexly relations, it is necessary to use Agile Model Driven Design (AMDD) approach as an advanced method to transforms MDA into components of application modules with efficiently and accurately. Finally, through the using of the CAF, give good achievement in fullfilment the needs from all stakeholders that are involved in the overall process stage of Rational Unified Process (RUP), and also obtaining a high satisfaction to fullfiled the functionality features of the ERP software in PT. Iglas (Persero) Gresik.

  12. Perancangan Case Tools untuk Diagram Use Case, Activity, dan Class untuk Permodelan Uml Berbasis Web Menggunakan HTML5 dan PHP

    Directory of Open Access Journals (Sweden)

    Mohammad Subekti

    2014-12-01

    Full Text Available This study is intended to generate an application tools (CASE tools that allows a software developer to create a modeling system design using Unified Modeling Language (UML, especially in making use case, activity or class diagrams more quickly and easily. The tools developed will also facilitate developers in doing UML modeling by accessing the network through a web-based internet application. With the web-based applications, the users require only a browser and an internet connection to use this application. This application also helps developers to understand of how to make UML diagrams correctly and good. In this research traditional methods Scrum model is used. Scrum method is Agile methods that is a process to cultivate software easily and can be developed in accordance with the development of information technology. Scrum is using empirical methods or in other words every stage in it involves inspection and adaptation.

  13. Behavioral Modeling of WSN MAC Layer Security Attacks: A Sequential UML Approach

    DEFF Research Database (Denmark)

    Pawar, Pranav M.; Nielsen, Rasmus Hjorth; Prasad, Neeli R.

    2012-01-01

    is the vulnerability to security attacks/threats. The performance and behavior of a WSN are vastly affected by such attacks. In order to be able to better address the vulnerabilities of WSNs in terms of security, it is important to understand the behavior of the attacks. This paper addresses the behavioral modeling...... of medium access control (MAC) security attacks in WSNs. The MAC layer is responsible for energy consumption, delay and channel utilization of the network and attacks on this layer can introduce significant degradation of the individual sensor nodes due to energy drain and in performance due to delays....... The behavioral modeling of attacks will be beneficial for designing efficient and secure MAC layer protocols. The security attacks are modeled using a sequential diagram approach of Unified Modeling Language (UML). Further, a new attack definition, specific to hybrid MAC mechanisms, is proposed....

  14. Diagram Size vs. Layout Flaws: Understanding Quality Factors of UML Diagrams

    DEFF Research Database (Denmark)

    Störrle, Harald

    2016-01-01

    , though, is our third goal of extending our analysis aspects of diagram quality. Method: We improve our definition of diagram size and add a (provisional) definition of diagram quality as the number of topographic layout flaws. We apply these metrics on 60 diagrams of the five most commonly used types...... of UML diagram. We carefully analyze the structure of our diagram samples to ensure representativeness. We correlate diagram size and layout quality with modeler performance data obtained in previous experiments. The data set is the largest of its kind (n-156). Results: We replicate earlier findings......, and extend them to two new diagram types. We provide an improved definition of diagram size, and provide a definition of topographic layout quality, which is one more step towards a comprehensive definition of diagram quality as such. Both metrics are shown to be objectively applicable. We quantify...

  15. Software engineering techniques applied to agricultural systems an object-oriented and UML approach

    CERN Document Server

    Papajorgji, Petraq J

    2014-01-01

    Software Engineering Techniques Applied to Agricultural Systems presents cutting-edge software engineering techniques for designing and implementing better agricultural software systems based on the object-oriented paradigm and the Unified Modeling Language (UML). The focus is on the presentation of  rigorous step-by-step approaches for modeling flexible agricultural and environmental systems, starting with a conceptual diagram representing elements of the system and their relationships. Furthermore, diagrams such as sequential and collaboration diagrams are used to explain the dynamic and static aspects of the software system.    This second edition includes: a new chapter on Object Constraint Language (OCL), a new section dedicated to the Model-VIEW-Controller (MVC) design pattern, new chapters presenting details of two MDA-based tools – the Virtual Enterprise and Olivia Nova, and a new chapter with exercises on conceptual modeling.  It may be highly useful to undergraduate and graduate students as t...

  16. Requirements for UML and OWL Integration Tool for User Data Consistency Modeling and Testing

    DEFF Research Database (Denmark)

    Nytun, J. P.; Jensen, Christian Søndergaard; Oleshchuk, V. A.

    2003-01-01

    The amount of data available on the Internet is continuously increasing, consequentially there is a growing need for tools that help to analyse the data. Testing of consistency among data received from different sources is made difficult by the number of different languages and schemas being used....... In this paper we analyze requirements for a tool that support integration of UML models and ontologies written in languages like the W3C Web Ontology Language (OWL). The tool can be used in the following way: after loading two legacy models into the tool, the tool user connects them by inserting modeling......, an important part of this technique is attaching of OCL expressions to special boolean class attributes that we call consistency attributes. The resulting integration model can be used for automatic consistency testing of two instances of the legacy models by automatically instantiate the whole integration...

  17. Using Unified Modelling Language (UML) as a process-modelling technique for clinical-research process improvement.

    Science.gov (United States)

    Kumarapeli, P; De Lusignan, S; Ellis, T; Jones, B

    2007-03-01

    The Primary Care Data Quality programme (PCDQ) is a quality-improvement programme which processes routinely collected general practice computer data. Patient data collected from a wide range of different brands of clinical computer systems are aggregated, processed, and fed back to practices in an educational context to improve the quality of care. Process modelling is a well-established approach used to gain understanding and systematic appraisal, and identify areas of improvement of a business process. Unified modelling language (UML) is a general purpose modelling technique used for this purpose. We used UML to appraise the PCDQ process to see if the efficiency and predictability of the process could be improved. Activity analysis and thinking-aloud sessions were used to collect data to generate UML diagrams. The UML model highlighted the sequential nature of the current process as a barrier for efficiency gains. It also identified the uneven distribution of process controls, lack of symmetric communication channels, critical dependencies among processing stages, and failure to implement all the lessons learned in the piloting phase. It also suggested that improved structured reporting at each stage - especially from the pilot phase, parallel processing of data and correctly positioned process controls - should improve the efficiency and predictability of research projects. Process modelling provided a rational basis for the critical appraisal of a clinical data processing system; its potential maybe underutilized within health care.

  18. The feasibility of using UML to compare the impact of different brands of computer system on the clinical consultation

    Directory of Open Access Journals (Sweden)

    Pushpa Kumarapeli

    2008-01-01

    Conclusions UML sequence diagrams are useful in identifying common tasks in the clinical consultation, and for contrasting the impact of the different brands of computer system on the clinical consultation. Further research is needed to see if patterns demonstrated in this pilot study are consistently displayed.

  19. Relationship Structures and Semantic Type Assignments of the UMLS Enriched Semantic Network

    Science.gov (United States)

    Zhang, Li; Halper, Michael; Perl, Yehoshua; Geller, James; Cimino, James J.

    2005-01-01

    Objective: The Enriched Semantic Network (ESN) was introduced as an extension of the Unified Medical Language System (UMLS) Semantic Network (SN). Its multiple subsumption configuration and concomitant multiple inheritance make the ESN's relationship structures and semantic type assignments different from those of the SN. A technique for deriving the relationship structures of the ESN's semantic types and an automated technique for deriving the ESN's semantic type assignments from those of the SN are presented. Design: The technique to derive the ESN's relationship structures finds all newly inherited relationships in the ESN. All such relationships are audited for semantic validity, and the blocking mechanism is used to block invalid relationships. The mapping technique to derive the ESN's semantic type assignments uses current SN semantic type assignments and preserves nonredundant categorizations, while preventing new redundant categorizations. Results: Among the 426 newly inherited relationships, 326 are deemed valid. Seven blockings are applied to avoid inheritance of the 100 invalid relationships. Sixteen semantic types have different relationship structures in the ESN as compared to those in the SN. The mapping of semantic type assignments from the SN to the ESN avoids the generation of 26,950 redundant categorizations. The resulting ESN contains 138 semantic types, 149 IS-A links, 7,303 relationships, and 1,013,876 semantic type assignments. Conclusion: The ESN's multiple inheritance provides more complete relationship structures than in the SN. The ESN's semantic type assignments avoid the existing redundant categorizations appearing in the SN and prevent new ones that might arise due to multiple parents. Compared to the SN, the ESN provides a more accurate unifying semantic abstraction of the UMLS Metathesaurus. PMID:16049233

  20. Enabling the usage of UML in the verification of railway systems: The DAM-rail approach

    International Nuclear Information System (INIS)

    Bernardi, S.; Flammini, F.; Marrone, S.; Mazzocca, N.; Merseguer, J.; Nardone, R.; Vittorini, V.

    2013-01-01

    The need for integration of model-based verification into industrial processes has produced several attempts to define Model-Driven solutions implementing a unifying approach to system development. A recent trend is to implement tool chains supporting the developer both in the design phase and V and V activities. In this Model-Driven context, specific domains require proper modelling approaches, especially for what concerns RAM (Reliability, Availability, Maintainability) analysis and fulfillment of international standards. This paper specifically addresses the definition of a Model-Driven approach for the evaluation of RAM attributes in railway applications to automatically generate formal models. For this aim we extend the MARTE-DAM UML profile with concepts related to maintenance aspects and service degradation, and show that the MARTE-DAM framework can be successfully specialized for the railway domain. Model transformations are then defined to generate Repairable Fault Tree and Bayesian Network models from MARTE-DAM specifications. The whole process is applied to the railway domain in two different availability studies

  1. EXTENSIÓN DEL METAMODELO DE UML PARA UNA ARQUITECTURA DE COMPONENTES

    Directory of Open Access Journals (Sweden)

    Fernando Orejas Valdés

    2006-12-01

    Full Text Available

     

     

    UML es un lenguaje de modelado estándar para problemas generales, sin embargo, es necesario extenderlo para dominios específicos como puede ser el caso de determinadas arquitecturas. En este caso se presenta una extensión de su metamodelo mediante la creación de nuevas metaclases y metaasociaciones para una arquitectura de componentes y conectores genéricos.

  2. A model-based design and validation approach with OMEGA-UML and the IF toolset

    Science.gov (United States)

    Ben-hafaiedh, Imene; Constant, Olivier; Graf, Susanne; Robbana, Riadh

    2009-03-01

    Intelligent, embedded systems such as autonomous robots and other industrial systems are becoming increasingly more heterogeneous with respect to the platforms on which they are implemented, and thus the software architecture more complex to design and analyse. In this context, it is important to have well-defined design methodologies which should be supported by (1) high level design concepts allowing to master the design complexity, (2) concepts for the expression of non-functional requirements and (3) analysis tools allowing to verify or invalidate that the system under development will be able to conform to its requirements. We illustrate here such an approach for the design of complex embedded systems on hand of a small case study used as a running example for illustration purposes. We briefly present the important concepts of the OMEGA-RT UML profile, we show how we use this profile in a modelling approach, and explain how these concepts are used in the IFx verification toolbox to integrate validation into the design flow and make scalable verification possible.

  3. Modeling Multi-Mobile Agents System Based on Coalition Signature Mechanism Using UML

    Institute of Scientific and Technical Information of China (English)

    SUNZhixin; HUANGHaiping; WANGRuchuan

    2004-01-01

    With the development of electronic commerce and agent techniques, multi-mobile agents cooperation can not only improve the efficiency of electronic business trade, but more importantly, it has a comprehensive applicative value in solving the security issues of mobile agent system. This paper firstly describes the mechanism of multi-mobile agents coalition signature aiming at the system security. Subsequently it brings forward a basic architecture of Multi-mobile agents system (MMAS) based on the design pattern of multi-mobile agents. The paper uses the diagrs_rn of UML, such as use case diagram, class diagram and sequence diagram to build the detailed model of the coalition signature and multi-mobile agents cooperation results. Through security analysis, we find that multimobile agents cooperation and interaction can solve some security problems of mobile agents in transfer, and also it can improve the efficiency of business trade. These results indicate that MMAS has a high security performance and can be widely used in E-commerce trade.

  4. The use of UML activity diagrams and the i* language in the modeling of the balanced scorecard implantation process

    OpenAIRE

    Haya, Mariela; Franch, Xavier; Mayol, Enric

    2005-01-01

    Business management is a complex task that can be facilitated using different methodologies and models. One of their most relevant purposes is to align the organization strategy with the daily functioning of the organization. One of these models is the Balanced Scorecard (BSC). In this paper, we propose a modeling strategy for the BSC implantation process. We will model it using UML Activity Diagrams and Strategy Dependency models of the language i*. The Activity Diagrams allow determining th...

  5. The feasibility of using UML to compare the impact of different brands of computer system on the clinical consultation.

    Science.gov (United States)

    Kumarapeli, Pushpa; de Lusignan, Simon; Koczan, Phil; Jones, Beryl; Sheeler, Ian

    2007-01-01

    UK general practice is universally computerised, with computers used in the consulting room at the point of care. Practices use a range of different brands of computer system, which have developed organically to meet the needs of general practitioners and health service managers. Unified Modelling Language (UML) is a standard modelling and specification notation widely used in software engineering. To examine the feasibility of UML notation to compare the impact of different brands of general practice computer system on the clinical consultation. Multi-channel video recordings of simulated consultation sessions were recorded on three different clinical computer systems in common use (EMIS, iSOFT Synergy and IPS Vision). User action recorder software recorded time logs of keyboard and mouse use, and pattern recognition software captured non-verbal communication. The outputs of these were used to create UML class and sequence diagrams for each consultation. We compared 'definition of the presenting problem' and 'prescribing', as these tasks were present in all the consultations analysed. Class diagrams identified the entities involved in the clinical consultation. Sequence diagrams identified common elements of the consultation (such as prescribing) and enabled comparisons to be made between the different brands of computer system. The clinician and computer system interaction varied greatly between the different brands. UML sequence diagrams are useful in identifying common tasks in the clinical consultation, and for contrasting the impact of the different brands of computer system on the clinical consultation. Further research is needed to see if patterns demonstrated in this pilot study are consistently displayed.

  6. OOAspectZ and aspect-oriented UML class diagrams for Aspect-oriented software modelling (AOSM

    Directory of Open Access Journals (Sweden)

    Cristian Vidal Silva

    2013-09-01

    Full Text Available Regarding modularised software development, Aspect-oriented programming (AOP identifies and represents individually crosscutting concerns during the software development cycle’s programming stage. This article proposes and applies OOAspectZ to formal Aspect-oriented requirement specifications for prior stages of the software development cycle. It particularly concerns requirement specification and the structural design of data and behaviour, along with describing and applying Aspect-oriented UML class diagrams to designing classes, aspects and associations among classes and aspects during Aspect-oriented software development (AOSD.OOAspectZ is a language integrating both Object-Z and AspectZ formal languages whereas Aspect-oriented UML class diagrams represent AOP code, object class and crosscutting concern class structure by means of stereotypes. This article shows and applies the main OOAspectZ and AO UML class diagram characteristics to Aspect-oriented software modelling (AOSM using a classic example of AOP. Ideas for future work concerning an actual AOP version are also indicated.

  7. Employing UMLS for generating hints in a tutoring system for medical problem-based learning.

    Science.gov (United States)

    Kazi, Hameedullah; Haddawy, Peter; Suebnukarn, Siriwan

    2012-06-01

    While problem-based learning has become widely popular for imparting clinical reasoning skills, the dynamics of medical PBL require close attention to a small group of students, placing a burden on medical faculty, whose time is over taxed. Intelligent tutoring systems (ITSs) offer an attractive means to increase the amount of facilitated PBL training the students receive. But typical intelligent tutoring system architectures make use of a domain model that provides a limited set of approved solutions to problems presented to students. Student solutions that do not match the approved ones, but are otherwise partially correct, receive little acknowledgement as feedback, stifling broader reasoning. Allowing students to creatively explore the space of possible solutions is exactly one of the attractive features of PBL. This paper provides an alternative to the traditional ITS architecture by using a hint generation strategy that leverages a domain ontology to provide effective feedback. The concept hierarchy and co-occurrence between concepts in the domain ontology are drawn upon to ascertain partial correctness of a solution and guide student reasoning towards a correct solution. We describe the strategy incorporated in METEOR, a tutoring system for medical PBL, wherein the widely available UMLS is deployed and represented as the domain ontology. Evaluation of expert agreement with system generated hints on a 5-point likert scale resulted in an average score of 4.44 (Spearman's ρ=0.80, p<0.01). Hints containing partial correctness feedback scored significantly higher than those without it (Mann Whitney, p<0.001). Hints produced by a human expert received an average score of 4.2 (Spearman's ρ=0.80, p<0.01). Copyright © 2012 Elsevier Inc. All rights reserved.

  8. Expanding the Extent of a UMLS Semantic Type via Group Neighborhood Auditing

    Science.gov (United States)

    Chen, Yan; Gu, Huanying; Perl, Yehoshua; Halper, Michael; Xu, Junchuan

    2009-01-01

    Objective Each Unified Medical Language System (UMLS) concept is assigned one or more semantic types (ST). A dynamic methodology for aiding an auditor in finding concepts that are missing the assignment of a given ST, S is presented. Design The first part of the methodology exploits the previously introduced Refined Semantic Network and accompanying refined semantic types (RST) to help narrow the search space for offending concepts. The auditing is focused in a neighborhood surrounding the extent of an RST, T (of S) called an envelope, consisting of parents and children of concepts in the extent. The audit moves outward as long as missing assignments are discovered. In the second part, concepts not reached previously are processed and reassigned T as needed during the processing of S's other RSTs. The set of such concepts is expanded in a similar way to that in the first part. Measurements The number of errors discovered is reported. To measure the methodology's efficiency, “error hit rates” (i.e., errors found in concepts examined) are computed. Results The methodology was applied to three STs: Experimental Model of Disease (EMD), Environmental Effect of Humans, and Governmental or Regulatory Activity. The EMD experienced the most drastic change. For its RST “EMD ∩ Neoplastic Process” (RST “EMD”) with only 33 (31) original concepts, 915 (134) concepts were found by the first (second) part to be missing the EMD assignment. Changes to the other two STs were smaller. Conclusion The results show that the proposed auditing methodology can help to effectively and efficiently identify concepts lacking the assignment of a particular semantic type. PMID:19567802

  9. AUTOMATIZACIÓN DE LA ARQUITECTURA DE COMPONENTES GENÉRICOS USANDO UML

    Directory of Open Access Journals (Sweden)

    Noel Fuentes Ramírez

    2006-04-01

    Full Text Available

     

    La arquitectura de componentes genéricos permite chequear la consistencia interna de sus elementos arquitectónicos (componentes y conectores a partir de las relaciones internas en sus respectivas estructuras, que pueden ser de inclusión y transformación. También permite verificar la conexión entre componentes y conectores a partir de las relaciones de transformación entre sus interfaces respectivas. Las ideas que se presentan aquí constituyen una propuesta para la automatización de la descripción de esta arquitectura usando el lenguaje de modelado unificado (UML a partir de la descripción formal de sus diagramas de clases y de secuencia, así como para el chequeo de la consistencia. En este artículo se muestra la aplicación de esta propuesta mediante una extensión de la herramienta Visual Paradigm, por medio de un módulo de software conectable.

  10. Consumers' Use of UMLS Concepts on Social Media: Diabetes-Related Textual Data Analysis in Blog and Social Q&A Sites.

    Science.gov (United States)

    Park, Min Sook; He, Zhe; Chen, Zhiwei; Oh, Sanghee; Bian, Jiang

    2016-11-24

    The widely known terminology gap between health professionals and health consumers hinders effective information seeking for consumers. The aim of this study was to better understand consumers' usage of medical concepts by evaluating the coverage of concepts and semantic types of the Unified Medical Language System (UMLS) on diabetes-related postings in 2 types of social media: blogs and social question and answer (Q&A). We collected 2 types of social media data: (1) a total of 3711 blogs tagged with "diabetes" on Tumblr posted between February and October 2015; and (2) a total of 58,422 questions and associated answers posted between 2009 and 2014 in the diabetes category of Yahoo! Answers. We analyzed the datasets using a widely adopted biomedical text processing framework Apache cTAKES and its extension YTEX. First, we applied the named entity recognition (NER) method implemented in YTEX to identify UMLS concepts in the datasets. We then analyzed the coverage and the popularity of concepts in the UMLS source vocabularies across the 2 datasets (ie, blogs and social Q&A). Further, we conducted a concept-level comparative coverage analysis between SNOMED Clinical Terms (SNOMED CT) and Open-Access Collaborative Consumer Health Vocabulary (OAC CHV)-the top 2 UMLS source vocabularies that have the most coverage on our datasets. We also analyzed the UMLS semantic types that were frequently observed in our datasets. We identified 2415 UMLS concepts from blog postings, 6452 UMLS concepts from social Q&A questions, and 10,378 UMLS concepts from the answers. The medical concepts identified in the blogs can be covered by 56 source vocabularies in the UMLS, while those in questions and answers can be covered by 58 source vocabularies. SNOMED CT was the dominant vocabulary in terms of coverage across all the datasets, ranging from 84.9% to 95.9%. It was followed by OAC CHV (between 73.5% and 80.0%) and Metathesaurus Names (MTH) (between 55.7% and 73.5%). All of the social

  11. A passage retrieval method based on probabilistic information retrieval model and UMLS concepts in biomedical question answering.

    Science.gov (United States)

    Sarrouti, Mourad; Ouatik El Alaoui, Said

    2017-04-01

    Passage retrieval, the identification of top-ranked passages that may contain the answer for a given biomedical question, is a crucial component for any biomedical question answering (QA) system. Passage retrieval in open-domain QA is a longstanding challenge widely studied over the last decades. However, it still requires further efforts in biomedical QA. In this paper, we present a new biomedical passage retrieval method based on Stanford CoreNLP sentence/passage length, probabilistic information retrieval (IR) model and UMLS concepts. In the proposed method, we first use our document retrieval system based on PubMed search engine and UMLS similarity to retrieve relevant documents to a given biomedical question. We then take the abstracts from the retrieved documents and use Stanford CoreNLP for sentence splitter to make a set of sentences, i.e., candidate passages. Using stemmed words and UMLS concepts as features for the BM25 model, we finally compute the similarity scores between the biomedical question and each of the candidate passages and keep the N top-ranked ones. Experimental evaluations performed on large standard datasets, provided by the BioASQ challenge, show that the proposed method achieves good performances compared with the current state-of-the-art methods. The proposed method significantly outperforms the current state-of-the-art methods by an average of 6.84% in terms of mean average precision (MAP). We have proposed an efficient passage retrieval method which can be used to retrieve relevant passages in biomedical QA systems with high mean average precision. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Lessons learned from a pilot implementation of the UMLS information sources map.

    Science.gov (United States)

    Miller, P L; Frawley, S J; Wright, L; Roderer, N K; Powsner, S M

    1995-01-01

    OBJECTIVE: To explore the software design issues involved in implementing an operational information sources map (ISM) knowledge base (KB) and system of navigational tools that can help medical users access network-based information sources relevant to a biomedical question. DESIGN: A pilot biomedical ISM KB and associated client-server software (ISM/Explorer) have been developed to help students, clinicians, researchers, and staff access network-based information sources, as part of the National Library of Medicine's (NLM) multi-institutional Unified Medical Language System (UMLS) project. The system allows the user to specify and constrain a search for a biomedical question of interest. The system then returns a list of sources matching the search. At this point the user may request 1) further information about a source, 2) that the list of sources be regrouped by different criteria to allow the user to get a better overall appreciation of the set of retrieved sources as a whole, or 3) automatic connection to a source. RESULTS: The pilot system operates in client-server mode and currently contains coded information for 121 sources. It is in routine use from approximately 40 workstations at the Yale School of Medicine. The lessons that have been learned are that: 1) it is important to make access to different versions of a source as seamless as possible, 2) achieving seamless, cross-platform access to heterogeneous sources is difficult, 3) significant differences exist between coding the subject content of an electronic information resource versus that of an article or a book, 4) customizing the ISM to multiple institutions entails significant complexities, and 5) there are many design trade-offs between specifying searches and viewing sets of retrieved sources that must be taken into consideration. CONCLUSION: An ISM KB and navigational tools have been constructed. In the process, much has been learned about the complexities of development and evaluation in this

  13. Lessons learned from a pilot implementation of the UMLS information sources map.

    Science.gov (United States)

    Miller, P L; Frawley, S J; Wright, L; Roderer, N K; Powsner, S M

    1995-01-01

    To explore the software design issues involved in implementing an operational information sources map (ISM) knowledge base (KB) and system of navigational tools that can help medical users access network-based information sources relevant to a biomedical question. A pilot biomedical ISM KB and associated client-server software (ISM/Explorer) have been developed to help students, clinicians, researchers, and staff access network-based information sources, as part of the National Library of Medicine's (NLM) multi-institutional Unified Medical Language System (UMLS) project. The system allows the user to specify and constrain a search for a biomedical question of interest. The system then returns a list of sources matching the search. At this point the user may request 1) further information about a source, 2) that the list of sources be regrouped by different criteria to allow the user to get a better overall appreciation of the set of retrieved sources as a whole, or 3) automatic connection to a source. The pilot system operates in client-server mode and currently contains coded information for 121 sources. It is in routine use from approximately 40 workstations at the Yale School of Medicine. The lessons that have been learned are that: 1) it is important to make access to different versions of a source as seamless as possible, 2) achieving seamless, cross-platform access to heterogeneous sources is difficult, 3) significant differences exist between coding the subject content of an electronic information resource versus that of an article or a book, 4) customizing the ISM to multiple institutions entails significant complexities, and 5) there are many design trade-offs between specifying searches and viewing sets of retrieved sources that must be taken into consideration. An ISM KB and navigational tools have been constructed. In the process, much has been learned about the complexities of development and evaluation in this new environment, which are different

  14. Using UMLS to map from a library to a clinical classification: Improving the functionality of a digital library.

    Science.gov (United States)

    Robinson, Judas; de Lusignan, Simon; Kostkova, Patty; Madge, Bruce

    2006-01-01

    The Metathesaurus of the Unified Medical Language System (UMLS) offers the possibility of mapping between various medical vocabularies. The Primary Care Electronic Library (PCEL) contains a database of over six thousand Medical Subject Headings (MeSH terms) describing the resources of the electronic library. We were interested to know if it was possible to map from MeSH to the Systemized Nomenclature of Medicine Clinical Terms (SNOMED CT). Such a mapping would aid healthcare professionals to retrieve relevant data from our digital library as it would enable links between clinical systems and indexed material.

  15. Modeling and analysis of real-time and embedded systems with UML and MARTE developing cyber-physical systems

    CERN Document Server

    Selic, Bran

    2013-01-01

    Modeling and Analysis of Real-Time and Embedded Systems with UML and MARTE explains how to apply the complex MARTE standard in practical situations. This approachable reference provides a handy user guide, illustrating with numerous examples how you can use MARTE to design and develop real-time and embedded systems and software. Expert co-authors Bran Selic and Sébastien Gérard lead the team that drafted and maintain the standard and give you the tools you need apply MARTE to overcome the limitations of cyber-physical systems. The functional sophistication required of modern cyber-physical

  16. Modeling Turkey National 2D Geo-Data Model as a CityGML Application Domain Extension in UML

    Directory of Open Access Journals (Sweden)

    Serpil Ates Aydar

    2016-12-01

    Full Text Available This paper presents the generation of the 3D national geo-data model of Turkey, which is compatible with the international OGC CityGML Encoding Standard. We prepare an ADE named CityGML-TRKBIS that is produced by extending existing thematic modules of CityGML according to TRKBIS needs. All thematic data groups in TRKBIS geo-data model have been remodeled in order to generate the national large scale 3D geodata model for Turkey. Within the concept of reference model-driven framework for modelling CityGML ADEs in UML, the first step is conceptual mapping between CityGML and national information model. To test all stages of the framework for Urban GIS Turkey, Building data theme is mapped with CityGML-Building thematic model. All classes, attributes, code lists and code list values of the TRKBIS is tried to be mapped with related CityGML concept. New classes, attributes and code list values that will be added to CityGML Building model are determined based on this conceptual mapping. Finally the new model for CityGML-TRKBIS.BI is established in UML with subclassing of the related CityGML classes. This study provides new insights into 3D applications in Turkey. The generated 3D geo-data model for building thematic class will be used as a common exchange format that meets 2D, 2.5D and 3D implementation needs at national level.

  17. Transformación del modelo de clases uml a oracle9i® bajo la directiva mda: un caso de estudio

    Directory of Open Access Journals (Sweden)

    FERNANDO ARANGO

    2006-01-01

    Full Text Available La Arquitectura Orientada a Modelos (MDA es la propuesta de refinamiento de la OMG orientada a la generación automática de código a partir de los Modelos UML de Sistemas Independientes de la Plataforma de Implementación. En este trabajo se presenta una metodología para transformar el Modelo de Clases UML a un Modelo UML Dependiente de la Plataforma Oracle9i®, siguiendo los lineamientos básicos presentados por esta arquitectura y utilizando a UML como lenguaje de modelado a través de todos los pasos de dicha transformación. Inicialmente las reglas de transformación del Modelo de Clases de UML al Modelo Objeto-Relacional soportado por Oracle9i® son recopiladas en Español y adaptadas a nivel de metamodelo, para lo cual fue necesario elaborar un metamodelo simplificado de la plataforma Oracle9i®. Este conjunto de reglas se hace automatizable al expresarlas en un formalismo lógico, que sea fácilmente ejecutable por una herramienta CASE que soporte un lenguaje formal. Finalmente, se aplican las reglas de refinamiento formalizadas al Modelo de Clases de un Caso Práctico de estudio obteniendo como resultado, un Modelo UML instancia del Metamodelo de la Plataforma Oracle9i®. Los aspectos del Modelo de Clases en los que se hace énfasis en la transformación son las invariantes y reglas de derivación de atributos definidas en el lenguaje formal OCL, así como las relaciones de asociación, composición y generalización entre Clases.

  18. Five Year Results of US Intergroup/RTOG 9704 With Postoperative CA 19-9 {<=}90 U/mL and Comparison to the CONKO-001 Trial

    Energy Technology Data Exchange (ETDEWEB)

    Berger, Adam C., E-mail: adam.berger@jefferson.edu [Thomas Jefferson University Hospital, Philadelphia, Pennsylvania (United States); Winter, Kathryn [RTOG Statistical Center, Philadelphia, Pennsylvania (United States); Hoffman, John P. [Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States); Regine, William F. [University of Maryland Medical Systems, Baltimore, Maryland (United States); Abrams, Ross A. [Rush University Medical Center, Chicago, Illinois (United States); Safran, Howard [Division of Hematology/Oncology, The Miriam Hospital, Providence, Rhode Island (United States); Freedman, Gary M. [Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States); Benson, Alan B. [Northwestern Memorial Hospital, Chicago, Illinois (United States); MacDonald, John [St. Vincent' s Comprehensive Cancer Center, New York, New York (United States); Willett, Christopher G. [Duke University Medical Center, Durham, North Carolina (United States)

    2012-11-01

    Purpose: Radiation Therapy Oncology Group (RTOG) trial 9704 was the largest randomized trial to use adjuvant chemoradiation therapy for patients with pancreatic cancer. This report analyzes 5-year survival by serum level of tumor marker CA 19-9 of {<=}90 vs >90 U/mL and compares results to the those of the CONKO-001 trial. Methods and Materials: CA 19-9 expression was analyzed as a dichotomized variable ({<=}90 vs >90 U/mL). Cox proportional hazard models were used to identify the impact of the CA 19-9 value on overall survival (OS). Actuarial estimates of OS were calculated using the Kaplan-Meier method. Results: Both univariate (hazard ratio [HR] = 3.2; 95% confidence interval [CI], 2.3-4.3, P<.0001) and multivariate (HR = 3.1; 95% CI, 2.2-4.2, P<.0001) analyses demonstrated a statistically significant decrease in OS for CA 19-9 serum level of {>=}90 U/mL. For patients in the gemcitabine (Gem) treatment arm with CA 19-9 <90 U/mL, median survival was 21 months. For patients with CA 19-9 {>=}90 U/mL, this number dropped to 10 months. In patients with pancreatic head tumors in the Gem treatment arm with RT quality assurance per protocol and CA 19-9 of <90 U/mL, median survival and 5-year rate were 24 months and 34%. In comparison, the median survival and 5-year OS rate for patients in the Gem arm of the CONKO trial were 22 months and 21%. Conclusions: This analysis demonstrates that patients with postresection CA 19-9 values {>=}90 U/mL had a significantly worse survival. Patients with pancreatic head tumors treated with Gem with CA 19-9 serum level of <90 U/mL and per protocol RT had favorable survival compared to that seen in the CONKO trial. CA 19-9 is a stratification factor for the current RTOG adjuvant pancreas trial (0848).

  19. Propuesta de Extensión de UML para Proceso de Conceptualización De Requisitos

    Directory of Open Access Journals (Sweden)

    Natalia Romero

    2016-06-01

    Full Text Available El Proceso de Conceptualización de Requisitos, estructurado en una primera fase de Análisis Orientado al Problema y una segunda fase de Análisis Orientado al Producto, tiene como objetivo principal mejorar la comprensión y captura de los requisitos actuando como vinculo entre las actividades de educción de requisitos y modelado conceptual. No obstante, para mejorar aún más la calidad de los modelos que se obtienen como resultado de la actividad de conceptualización y facilitar la comunicación entre los distintos partícipes del proceso de software se propone en este trabajo una extensión de UML para dar soporte al proceso de conceptualización de requisitos con herramientas estándar y de uso difundido.

  20. Integrating UML, the Q-model and a Multi-Agent Approach in Process Specifications and Behavioural Models of Organisations

    Directory of Open Access Journals (Sweden)

    Raul Savimaa

    2005-08-01

    Full Text Available Efficient estimation and representation of an organisation's behaviour requires specification of business processes and modelling of actors' behaviour. Therefore the existing classical approaches that concentrate only on planned processes are not suitable and an approach that integrates process specifications with behavioural models of actors should be used instead. The present research indicates that a suitable approach should be based on interactive computing. This paper examines the integration of UML diagrams for process specifications, the Q-model specifications for modelling timing criteria of existing and planned processes and a multi-agent approach for simulating non-deterministic behaviour of human actors in an organisation. The corresponding original methodology is introduced and some of its applications as case studies are reviewed.

  1. UN MÉTODO DE INGENIERÍA INVERSA DE CÓDIGO JAVA HACIA DIAGRAMAS DE SECUENCIAS DE UML 2.0

    Directory of Open Access Journals (Sweden)

    Carlos Mario Zapata

    2008-07-01

    Full Text Available La Ingeniería inversa de software aparece como un proceso que ayuda al aseguramiento de la calidad y documentación de aplicaciones con deficiencias en los modelos de análisis y diseño. Además, ayuda en la disminución de costos y tiempos de mantenimiento. En la actualidad existen herramientas CASE y algunas propuestas de investigación que realizan el proceso de ingeniería inversa a diagramas UML, en especial a los diagramas de clases y secuencias. Algunas se encuentran en fases experimentales; otras se enfocan mucho más en el diagrama de clases que en el de secuencias. Un tercer grupo obtiene algunos elementos del diagrama de secuencias, pero no posee muchos de los elementos que hacen parte de la especificación de UML 2.0. En este artículo se propone un método que automatiza la conversión de código JAVA en diagrama de secuencias de UML 2.0, por medio de la aplicación de reglas de transformación que convierten los elementos del código en elementos del diagrama. Se presenta también un ejemplo de aplicación del método con un prototipo que lo emplea, el UNC-Inversor.Software reverse engineering seems to be the process for helping software quality assurance and documentation in applications with low-quality analysis and design models. It also helps for decreasing maintenance cost and time. Currently, some CASE tools and research proposals assist analysts to develop reverse engineering process with UML diagrams as a result (especially class and sequence diagram. Some of them have reached experimental phases. Some others are focused more on class diagram and less on sequence diagram. A third group of CASE tools and proposals obtains sequence diagram, but the resulting diagram lacks some of the elements of the UML 2.0 specification. In this paper, we propose a method for automating the conversion of JAVA code into UML 2.0 sequence diagram, by means of the application of transformation rules for converting code elements to the diagram

  2. Combining UML2 Application and SystemC Platform Modelling for Performance Evaluation of Real-Time Embedded Systems

    Directory of Open Access Journals (Sweden)

    Qu Yang

    2008-01-01

    Full Text Available Abstract Future mobile devices will be based on heterogeneous multiprocessing platforms accommodating several stand-alone applications. The network-on-chip communication and device networking combine the design challenges of conventional distributed systems and resource constrained real-time embedded systems. Interoperable design space exploration for both the application and platform development is required. Application designer needs abstract platform models to rapidly check the feasibility of a new feature or application. Platform designer needs abstract application models for defining platform computation and communication capacities. We propose a layered UML application/workload and SystemC platform modelling approach that allow application and platform to be modelled at several levels of abstraction, which enables early performance evaluation of the resulting system. The overall approach has been experimented with a mobile video player case study, while different load extraction methods have been validated by applying them to MPEG-4 encoder, Quake2 3D game, and MP3 decoder case studies previously.

  3. SISTEM INFORMASI REALISASI BEBAN KERJA SALES DAN MARKETING BERBASIS WEB DENGAN PERMODELAN UML (STUDY KASUS: LKP PALCOMTECH

    Directory of Open Access Journals (Sweden)

    Dini Hari Pertiwi

    2017-12-01

    Full Text Available Sebuah website sudah mulai banyak digunakan oleh organisasi atau perusahaan dengan tujuan sebagai media komunikasi, promosi atau bahkan menjadi media transaksi bagi perusahaan tersebut. Karena banyaknya kemampuan yang dimiliki oleh sebuah website maka perusahaan mulai banyak memanfaatkan website untuk kebutuhan yang lainnya, salah satu pemanfaatan website yaitu digunakan untuk pemantauan target kerja yang dilakukan oleh bagian sales dan marketing. Pembagian target kerja akan langsung dibagi berdasarkan potensi cabang masing-masing sehingga kepala cabang, koordinator cabang dapat langsung melakukan pemantauan terhadap capaian yang dilakukan oleh sales dan marekting terhadapt target yang diberikan. Karena website yang dapat menjadi media komunikasi pemcapaian realisasi target kerja maka website dibuat dengan menggunakan permodelan UML (Unified Modeling Language untuk memudahkan jika suatu saat akan dilakukan pengembangan sistem informasi realisasi beban kerja sales dan marketing. Sistem informasi realisasi beban kerja sales dan marketing akan menyimpan informasi target untuk masing-masing cabang, nama produk yang akan dipromosikan, serta akan menyimpan data konsumen dan capaian yang dilakukan oleh sales dan marketing. Realisasi pencapaian dapat langsung dilihat melalui dashboard masing-masing kepala cabang dan koordinator cabang sehingga tidak perlu menunggu laporan yang dikirimkan oleh masing-masing sales dan marketing. Sistem informasi realisasi beban kerja sales dan marketing ini dibuat dengan menggunakan bahasa pemrograman Framework PHP yaitu  codeigniter sedangkan database yang digunakan adalah MySQL.

  4. MODELAGEM DE UM SISTEMA ESPECIALISTA PARA APRIMORAR PRODUTOS E PROCESSOS NA PRODUÇÃO DE LEITE UTILIZANDO A UML /MODELING AN EXPERT SYSTEM TO IMPROVE PRODUCTS AND PROCESSES IN THE MILK PRODUCTION USING THE UML

    Directory of Open Access Journals (Sweden)

    Mario Mollo Neto

    2010-11-01

    Full Text Available A zootecnia de precisão permite o desenvolvimento de ferramentas automatizadas que fornecem um acompanhamento detalhado do plantel, aumentando a rentabilidade, e protegendo os animais racionalmente. O setor agropecuário brasileiro, em decorrência das intempéries da economia mundial globalizada, vem, de maneira crescente, se adaptando à utilização destas ferramentas automatizadas para suporte à tomada de decisão. A laminite é a patologia de maior custo para o gado de leite confinado. Suas causas incluem condições climáticas, de alojamento, de alimentação e a presença de pisos mais abrasivos. Baseando-se nessas informações é possível, utilizando o algoritmo correto, construir um modelo que permita ao usuário estimar a possibilidade de incidência de laminite em gado leiteiro, a partir de dados históricos ou mesmo de outras variáveis que causam a patologia. Neste trabalho foi realizada a modelagem, utilizando a Universal Modelling Language (UML, de um sistema especialista com motor de inferência Fuzzy para o diagnóstico preventivo desta patologia que reduza os impactos na produção e no conforto animal. A partir da modelagem realizada ficam disponíveis novas bases para a futura codificação e construção do sistema especialista para mitigar a patologia de casco, reduzir os impactos de perdas de receita relacionados e ampliar o conforto animal. Palavras-chave: Laminite, Sistema Especialista, Suporte a Decisão, Lógica Fuzzy, Diagnóstico Preventivo, Bem-estar animal, Modelagem.

  5. [Modeling the requirements on routine data of general practitioners from the health-care researcher's point of view with the help of unified modeling langauge (UML)].

    Science.gov (United States)

    Kersting, M; Hauswaldt, J; Lingner, H

    2012-08-01

    Health-care research is, besides primary acquired study data, based on data from widely differing secondary sources. In order to link, compare and analyze data sources uniform models and methods are needed. This could be facilitated by a more structured description of requirements, models and methods of health-care research than those currently used. Suitable methods of presentation were sought in an approach to this target and the unified modeling language (UML) identified as a possible alternative. Using different tools 3 UML diagrams were created to represent some individual aspects of a scientific use file (SUF): A use case diagram as well as an activity and a class diagram. In the use case diagram we attempted to represent the general use cases of an SUF based on general practitioners routine data. Secondly a class diagram was constructed to visualize the contents and structure of a SUF. Thirdly an activity diagram was developed to graphically represent the concept of a general practitioner's episode of care. The creation of the UML diagrams was possible without any technical difficulties. Regarding the content the 3 diagrams must still be considered as prototypes. The use case diagram shows possible uses and users of an SUF, e. g. a research worker, industry but also the general practitioner who supplies the data. The class diagram reveals a general data structure that can serve information processes in practice and research. Besides aggregation, possibilities for specialization and generalization are essential elements of the class diagram that can be used meaningfully. The activity diagram for the schematic representation of a general practitioner's episode of care reveals the existence of multiple endpoints of an episode and the possibility to form relationships by means of episodes (diagnosis>therapy). The constructed diagrams are preliminary results and should be refined in future steps. Use case diagrams enable a rapid overview of the meaning and

  6. Especificación formal en OCL de reglas de consistencia entre los diagramas de clases y casos de uso de UML y el modelo de interfaces Formal OCL specification of consistency rules between the UML class and the use case models and the interfaces model

    Directory of Open Access Journals (Sweden)

    Carlos Mario Zapata

    2008-01-01

    Full Text Available En el ciclo de vida del software, durante las fases de definición y análisis, se realiza una especificación de los requisitos. Para ello, es necesario realizar un proceso de captura de las necesidades y expectativas de los interesados, que se traduce posteriormente en un conjunto de modelos que representan tanto el problema como su solución. Por lo general, la mayoría de esos modelos se expresan en el lenguaje de modelado unificado -UML-, que define un conjunto de artefactos que permiten especificar los requisitos del software, los cuales deberían guardar consistencia, cuando se trate del mismo modelo. Sin embargo, la consistencia entre diferentes artefactos no se encuentra definida en la especificación de UML y poco se ha trabajado con este tipo de consistencia. En este artículo se propone un método para verificar la consistencia entre el diagrama de clases y el diagrama de casos de uso de UML de una manera formal. Dicho proceso se lleva a cabo evaluando una serie de reglas definidas en el lenguaje de restricciones de objetos -OCL- que se deben cumplir para garantizar que la información brindada por dichos modelos sea consistente. Como se reconoce la participación de los dos diagramas en la elaboración de las interfaces gráficas de usuario -GUI-, se define adicionalmente la consistencia con este artefacto.In a software lifetime, during definition and analysis stages, a specification of requirements is carried out. For such a purpose, it is necessary to get through a process to capture interested persons’ needs and expectations, which will later be translated into a set of models representing both the problem and the solution. Most models are frequently expressed by the UML (Unified Modeling Language which defines a set of devices for specifying software requirements which should be consistent with the same model. However, consistency among several devices is not defined in the UML specification and not too much work has been made

  7. Methodology for the development and the UML (unified modified language) simulation of data acquisition and data processing systems dedicated to high energy physics experiments

    International Nuclear Information System (INIS)

    Anvar, S.

    2002-09-01

    The increasing complexity of the real-time data acquisition and processing systems (TDAQ: the so called Trigger and Data AcQuisition systems) in high energy physics calls for an appropriate evolution of development tools. This work is about the interplay between in principle specifications of TDAQ systems and their actual design and realization on a concrete hardware and software platform. The basis of our work is to define a methodology for the development of TDAQ systems that meets the specific demands for the development of such systems. The result is the detailed specification of a 'methodological framework' based on the Unified Modeling Language (UML) and designed to manage a development process. The use of this UML-based methodological framework progressively leads to the setting up of a 'home-made' framework, i.e. a development tool that comprises reusable components and generic architectural elements adapted to TDAQ systems. The main parts of this dissertation are sections II to IV. Section II is devoted to the characterization and evolution of TDAQ systems. In section III, we review the main technologies that are relevant to our problematic, namely software reuse techniques such as design patterns and frameworks, especially concerning the real-time and embedded systems domain. Our original conceptual contribution is presented in section IV, where we give a detailed, formalized and example-driven specification of our development model. Our final conclusions are presented in section V, where we present the MORDICUS project devoted to a concrete realization of our UML methodological framework, and the deep affinities between our work and the emerging 'Model Driven Architecture' (MDA) paradigm developed by the Object Management Group. (author)

  8. 基于UML的PPP项目融资管理信息系统的分析%Analysis of PPP Project Financing Management Information System Based on UML

    Institute of Scientific and Technical Information of China (English)

    郭卫萍; 何楠

    2012-01-01

    PPP项目融资过程中,为便于各主体之间以及主体与外部环境之间信息的流通与传递,实现PPP项目融资过程中的信息化管理,运用UML可视化建模语言对PPP项目融资管理信息系统进行功能分析,创建用例图、类图和顺序图等,从而为后期开发PPP项目融资管理信息系统奠定基础。%In the process of PPP project financing, in order to facilitate the circulation and transmission of information between the main bodies and between the subject and external environment, and realize the process of information management of the PPP project fi- nancing, this paper uses the visualized modeling language UML throughout the whole process of the design of the PPP project financing management information system, and introduces the concept and features of PPP financing model and the related concepts of UML mod- eling firstly, then analyses the function of the PPP project financing management information system, and finally, analyses PPP project financing management information system with the UML modeling. It creates the use case diagram, the class diagram and the sequence diagram for the PPP project financing management information system. Thus it lays foundation for the later development of PPP project financing management information system.

  9. 基于UML的自动组卷系统的分析与设计%Design and Analysis of Automatic Generation of Test Paper System Based on UML

    Institute of Scientific and Technical Information of China (English)

    刘慧梅

    2012-01-01

      本文运用基于面向对象的建模语言 UML 对自动组卷系统进行分析和设计,建立了自动组卷系统分析设计模型,为实现自动组卷系统打下良好的基础。%  this paper analyzed and designed the automatic generation of test paper system by UML, construct the design model based on analysis of the automatic generation of test paper system, and fully prepare for the realization of the automatic generation of test paper system.

  10. Methodology for the development and the UML (unified modified language) simulation of data acquisition and data processing systems dedicated to high energy physics experiments; Methodologie de developpement et de modelisation UML des systemes d'acquisition et de traitement en temps reel pour les experiences de physique des hautes energies

    Energy Technology Data Exchange (ETDEWEB)

    Anvar, S

    2002-09-01

    The increasing complexity of the real-time data acquisition and processing systems (TDAQ: the so called Trigger and Data AcQuisition systems) in high energy physics calls for an appropriate evolution of development tools. This work is about the interplay between in principle specifications of TDAQ systems and their actual design and realization on a concrete hardware and software platform. The basis of our work is to define a methodology for the development of TDAQ systems that meets the specific demands for the development of such systems. The result is the detailed specification of a 'methodological framework' based on the Unified Modeling Language (UML) and designed to manage a development process. The use of this UML-based methodological framework progressively leads to the setting up of a 'home-made' framework, i.e. a development tool that comprises reusable components and generic architectural elements adapted to TDAQ systems. The main parts of this dissertation are sections II to IV. Section II is devoted to the characterization and evolution of TDAQ systems. In section III, we review the main technologies that are relevant to our problematic, namely software reuse techniques such as design patterns and frameworks, especially concerning the real-time and embedded systems domain. Our original conceptual contribution is presented in section IV, where we give a detailed, formalized and example-driven specification of our development model. Our final conclusions are presented in section V, where we present the MORDICUS project devoted to a concrete realization of our UML methodological framework, and the deep affinities between our work and the emerging 'Model Driven Architecture' (MDA) paradigm developed by the Object Management Group. (author)

  11. Methodology for the development and the UML (unified modified language) simulation of data acquisition and data processing systems dedicated to high energy physics experiments; Methodologie de developpement et de modelisation UML des systemes d'acquisition et de traitement en temps reel pour les experiences de physique des hautes energies

    Energy Technology Data Exchange (ETDEWEB)

    Anvar, S

    2002-09-01

    The increasing complexity of the real-time data acquisition and processing systems (TDAQ: the so called Trigger and Data AcQuisition systems) in high energy physics calls for an appropriate evolution of development tools. This work is about the interplay between in principle specifications of TDAQ systems and their actual design and realization on a concrete hardware and software platform. The basis of our work is to define a methodology for the development of TDAQ systems that meets the specific demands for the development of such systems. The result is the detailed specification of a 'methodological framework' based on the Unified Modeling Language (UML) and designed to manage a development process. The use of this UML-based methodological framework progressively leads to the setting up of a 'home-made' framework, i.e. a development tool that comprises reusable components and generic architectural elements adapted to TDAQ systems. The main parts of this dissertation are sections II to IV. Section II is devoted to the characterization and evolution of TDAQ systems. In section III, we review the main technologies that are relevant to our problematic, namely software reuse techniques such as design patterns and frameworks, especially concerning the real-time and embedded systems domain. Our original conceptual contribution is presented in section IV, where we give a detailed, formalized and example-driven specification of our development model. Our final conclusions are presented in section V, where we present the MORDICUS project devoted to a concrete realization of our UML methodological framework, and the deep affinities between our work and the emerging 'Model Driven Architecture' (MDA) paradigm developed by the Object Management Group. (author)

  12. Design of an UML conceptual model and implementation of a GIS with metadata information for a seismic hazard assessment cooperative project.

    Science.gov (United States)

    Torres, Y.; Escalante, M. P.

    2009-04-01

    This work illustrates the advantages of using a Geographic Information System in a cooperative project with researchers of different countries, such as the RESIS II project (financed by the Norwegian Government and managed by CEPREDENAC) for seismic hazard assessment of Central America. As input data present different formats, cover distinct geographical areas and are subjected to different interpretations, data inconsistencies may appear and their management get complicated. To achieve data homogenization and to integrate them in a GIS, it is required previously to develop a conceptual model. This is accomplished in two phases: requirements analysis and conceptualization. The Unified Modeling Language (UML) is used to compose the conceptual model of the GIS. UML complies with ISO 19100 norms and allows the designer defining model architecture and interoperability. The GIS provides a frame for the combination of large geographic-based data volumes, with an uniform geographic reference and avoiding duplications. All this information contains its own metadata following ISO 19115 normative. In this work, the integration in the same environment of active faults and subduction slabs geometries, combined with the epicentres location, has facilitated the definition of seismogenetic regions. This is a great support for national specialists of different countries to make easier their teamwork. The GIS capacity for making queries (by location and by attributes) and geostatistical analyses is used to interpolate discrete data resulting from seismic hazard calculations and to create continuous maps as well as to check and validate partial results of the study. GIS-based products, such as complete, homogenised databases and thematic cartography of the region, are distributed to all researchers, facilitating cross-national communication, the project execution and results dissemination.

  13. A Review of the Clinical Efficacy and Safety of Insulin Degludec and Glargine 300 U/mL in the Treatment of Diabetes Mellitus.

    Science.gov (United States)

    Woo, Vincent C

    2017-08-01

    The treatment of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) using insulin is not ideal at this time. Despite advances made with basal insulin analogues, many individuals achieve less than optimal glycemic control or are at risk for hypoglycemia. Currently available basal insulin analogues do not deliver steady, peakless, continuous insulin for >24 hours and are associated with adverse events, including hypoglycemia. The objective of this paper was to review the clinical efficacy and safety of upcoming long-acting insulin analogues such as insulin degludec and insulin glargine 300 U/mL (Gla-300). A comprehensive literature search of PubMed and Google Scholar was conducted from 1966 to 2015. The search included randomized controlled trials that specifically assessed the efficacy and safety of insulin degludec and Gla-300 in patients with T1DM and T2DM. The efficacy of insulin degludec and Gla-300 in achieving glycemic control has been reported in clinical trials in adults with T1DM and T2DM. Not only did a large number of patients succeed in meeting glycosylated hemoglobin targets, but they also experienced reductions in hypoglycemic events. These 2 therapies are associated with a reduced risk of nocturnal hypoglycemia and are generally well tolerated. The long-acting insulin analogues insulin degludec and Gla-300 are promising therapies in the treatment of T1DM and T2DM. Their improved insulin delivery for >24 hours offers glycemic control with a good safety profile. Copyright © 2017 Elsevier HS Journals, Inc. All rights reserved.

  14. Optimizing Glycemic Control Through Titration of Insulin Glargine 100 U/mL: A Review of Current and Future Approaches with a Focus on Asian Populations.

    Science.gov (United States)

    Deerochanawong, Chaicharn; Bajpai, Shailendra; Dwipayana, I Made Pande; Hussein, Zanariah; Mabunay, Maria Aileen; Rosales, Reynaldo; Tsai, Shih-Tzer; Tsang, Man Wo

    2017-12-01

    Various data have demonstrated inadequate glycemic control amongst Asians with type 2 diabetes mellitus (T2DM), possibly on account of suboptimal titration of basal insulin-an issue which needs to be further examined. Here we review the available global and Asia-specific data on titration of basal insulin, with a focus on the use of insulin glargine 100 U/mL (Gla-100). We also discuss clinical evidence on the efficacy and safety of titrating Gla-100, different approaches to titration, including some of the latest technological advancements, and guidance on the titration of basal insulin from international and local Asian guidelines. The authors also provide their recommendations for the initiation and titration of basal insulin for Asian populations. Discussion of the data included in this review and in relation to the authors' clinical experience with treating T2DM in Asian patients is also included. Briefly, clinical studies demonstrate the achievement of adequate glycemic control in adults with T2DM through titration of Gla-100. However, studies investigating approaches to titration, specifically in Asian populations, are lacking and need to be conducted. Given that the management of insulin therapy is a multidisciplinary team effort involving endocrinologists, primary care physicians, nurse educators, and patients, greater resources and education targeted at these groups are needed regarding the optimal titration of basal insulin. Technological advancements in the form of mobile or web-based applications for automated dose adjustment can aid different stakeholders in optimizing the dose of basal insulin, enabling a larger number of patients in Asia to reach their target glycemic goals with improved outcomes.

  15. In the pursuit of a semantic similarity metric based on UMLS annotations for articles in PubMed Central Open Access.

    Science.gov (United States)

    Garcia Castro, Leyla Jael; Berlanga, Rafael; Garcia, Alexander

    2015-10-01

    full-text articles annotated with UMLS concepts. For similarity values above 0.8, all metrics exhibited an F1 around 0.2 and a recall around 0.1; BM25 showed the highest precision close to 1; in all cases the concept-based metrics performed better than the word-stem-based one. Our experiments show that similarity values vary when considering only title-and-abstract versus full-text similarity. Therefore, analyses based on full-text become useful when a given research requires going beyond title and abstract, particularly regarding connectivity across articles. Visualization available at ljgarcia.github.io/semsim.benchmark/, data available at http://dx.doi.org/10.5281/zenodo.13323. Copyright © 2015 Elsevier Inc. All rights reserved.

  16. JGOOSE: A REQUIREMENTS ENGINEERING TOOL TO INTEGRATE I* ORGANIZATIONAL MODELING WITH USE CASES IN UML JGOOSE: UNA HERRAMIENTA DE INGENIERÍA DE REQUISITOS PARA LA INTEGRACIÓN DE L MODELADO ORGANIZACIONAL I* CON EL MODELADO DE CASOS DE USO EN UML

    Directory of Open Access Journals (Sweden)

    André Abe Vicente

    2009-04-01

    Full Text Available Nowadays Computational Systems are being characterized by their complexity, dynamism and great strategic importance. In this complex context of software specification, generating high quality documentation is very difficult. Usually, clients are not sure about their needs and sometimes software requirements do not represent clients and organizational environment needs. Inconsistent and incomplete requirements are very frequent. One of the challenges to solve this problem is to integrate organizational and functional requirements of the system to be developed. In this paper the JGOOSE (Java Goal into Object Oriented Standard Extension tool used to assist requirement engineers in the development of use cases from the organizational models represented by i* technique is presented. To validate the tool, it was used and applied to the Conference Management System case study.En los días actuales los sistemas computacionales se caracterizan por su complejidad, dinamismo y gran importancia estratégica. En este complejo escenario de especificación de software, generar documentación de alta calidad es una difícil tarea. En general los clientes no saben exactamente lo que desean y muchas veces los requisitos del software no reflejan las reales necesidades de los clientes y del ambiente organizacional. Es bastante común encontrar requisitos inconsistentes e incompletos. En este contexto, uno de los grandes desafíos está en la necesidad de integrar los requisitos organizacionales y funcionales del sistema computacional que será desarrollado. En este trabajo se presenta la herramienta computacional JGOOSE (Java Goal Into Object Oriented Standard Extension que permite integrar diagramas de casos de uso en UML con requisitos organizacionales representados utilizando la técnica i*. Se presenta la utilización de la herramienta en el caso de estudio de un Sistema de Gestión de Evento Científico.

  17. Aproximación Basada en UML para el Diseño y Codificación Automática de Plataformas Robóticas Manipuladoras

    Directory of Open Access Journals (Sweden)

    Elisabet Estévez

    2017-01-01

    Full Text Available Resumen: Hoy en día, los robots manipuladores están presentes en todas las instalaciones de producción moderna industriales. Por ello, a la robótica manipuladora se la considera una disciplina decisiva en el sector industrial. Además, en un futuro no muy lejano los robots manipuladores pasarán a ser también esenciales en la vida cotidiana de la sociedad. Así, existe una demanda creciente de aplicaciones con robots manipuladores con requisitos software como son la reutilización, flexibilidad y adaptabilidad. Lamentablemente, en la actualidad hay una falta de estandarización de plataformas hardware y software, por lo que es extremadamente complicado satisfacer estos requisitos. Así, se contempla, por lo tanto, una necesidad de definir una metodología que proporcione unas pautas y guíe en el diseño, implementación y en la ejecución de sistemas software para este tipo de aplicaciones. Este trabajo explora las ventajas proporcionadas por la Ingeniería Dirigida por Modelos (MDE- Model Driven Engineering en el diseño y desarrollo de tareas realizadas por robots manipuladores. En concreto se propone una aproximación basada en un sub-conjunto de diagramas UML (diagrama de componentes y diagrama de despliegue para el diseño de este tipo de aplicaciones. Además, se identifican y definen los pasos a realizar para la generación automática de código que se ejecutará sobre los middlewares (MW de comunicación más utilizados en esta disciplina. Para ello, se hará uso de las técnicas Model-To-Model y Model-To-Text nuevamente de MDE. Este trabajo, detalla la generación del código para OROCOS (el MW basado en componentes más extendido y ROS. Finalmente, se presentan dos casos de estudio, el primero de ellos consiste en una aplicación industrial para el ensamblado de faro de vehículos que se ejecuta sobre OROCOS. El segundo caso de estudio es una aplicación de

  18. Reglas para la generación automática de código definidas sobre metamodelos simplificados de los diagramas de clases, secuencias y máquina de estados de UML 2.0

    Directory of Open Access Journals (Sweden)

    ANDRÉS MUÑETÓN

    2007-01-01

    Full Text Available La generación automática de código a partir de modelos ha sido una de las promesas parcialmente cumplidas en el desarrollo de software. La experiencia de las herramientas CASE, aún distante del automatismo absoluto, se complementa con algunos trabajos teóricos que se alejan de los estándares de modelamiento. En este artículo se proponen reglas para la generación de código a partir de metamodelos de diagramas de clases, secuencias y máquina de estados de UML. Las reglas están definidas en lógica de primer orden, permitiendo una especificación donde se evitan las ambigüedades y la necesidad de aprender un lenguaje de programación específico. Mediante un caso de estudio se representa la aplicación de las reglas de transformación, generando el código fuente de una clase en el lenguaje orientado a objetos Java

  19. UML modelling of network warfare examples

    CSIR Research Space (South Africa)

    Veerasamy, N

    2011-08-01

    Full Text Available ] Affects both civilian and military domains [8] [9] Related to the concepts of infowar, information operations, hacking, hackivism, cyberterrorism and cybotage depending on motivations and techniques [10] Encompasses both technological solutions...]. In addition, Williers as well as Qingbao and Anwar discuss more offensive aspects of information security and Network Warfare like Hacking, Vulnerability Injection, Network Attacks, Denial of Capability, Interception and Blockage [6] [18] [19]. Various...

  20. Towards Clone Detection in UML Domain Models

    DEFF Research Database (Denmark)

    Störrle, Harald

    2010-01-01

    Code clones - that is, duplicate fragments of code - have been studied for a long time. There is strong evidence that code clones are a major source of software faults. Anecdotal evidence suggests that this phenomenon is not restricted to code, but occurs in models in a very similar way. So it is...

  1. Leveraging the UML Metamodel: Expressing ORM Semantics Using a UML Profile

    Energy Technology Data Exchange (ETDEWEB)

    CUYLER,DAVID S.

    2000-11-01

    Object Role Modeling (ORM) techniques produce a detailed domain model from the perspective of the business owner/customer. The typical process begins with a set of simple sentences reflecting facts about the business. The output of the process is a single model representing primarily the persistent information needs of the business. This type of model contains little, if any reference to a targeted computerized implementation. It is a model of business entities not of software classes. Through well-defined procedures, an ORM model can be transformed into a high quality objector relational schema.

  2. Integrating decision management with UML modeling concepts and tools

    DEFF Research Database (Denmark)

    Könemann, Patrick

    2009-01-01

    , but also for guiding the user by proposing subsequent decisions. In model-based software development, many decisions directly affect the structural and behavioral models used to describe and develop a software system and its architecture. However, the decisions are typically not connected to these models...... of formerly disconnected tools could improve tool usability as well as decision maker productivity....

  3. Integrating a Decision Management Tool with UML Modeling Tools

    DEFF Research Database (Denmark)

    Könemann, Patrick

    by proposing potential subsequent design issues. In model-based software development, many decisions directly affect the structural and behavioral models used to describe and develop a software system and its architecture. However, these decisions are typically not connected to the models created during...... integration of formerly disconnected tools improves tool usability as well as decision maker productivity....

  4. Designing Interaction Spaces for Rich Internet Applications with UML

    DEFF Research Database (Denmark)

    Dolog, Peter; Stage, Jan

    2007-01-01

    In this paper, we propose a new method for designing rich internet applications. The design process uses results from an object-oriented analysis and employs interaction spaces as the basic abstraction mechanism. State diagrams are employed as refinements of interaction spaces and task models...

  5. Performance Evaluation of Superscalar Processor Architecture Through UML

    OpenAIRE

    Taskeen Zaidi; Vipin Saxena

    2013-01-01

    In the current scenario, most of the applications are based upon graphical user interface and dependent upon the object-oriented technology. Software Industries are interested to convert old structured based softwares into object-oriented based softwares and also to reduce the lines of the code of application for reduction in the execution time of application. Therefore, it is a big challenge to reduce the execution time of the application based upon the object-oriented technology. The presen...

  6. Advanced Systems Design with Java, UML and MDA

    CERN Document Server

    Lano, Kevin

    2005-01-01

    Model Driven Architecture is a significant evolution of the object-oriented approach to system development. This book describes the factors involved in designing and constructing large systems, illustrating the design process through a series of examples, including a Scrabble player, a jukebox using web streaming, a security system, and others.

  7. Execution Constraint Verification of Exception Handling on UML Sequence Diagrams

    NARCIS (Netherlands)

    Ciraci, S.; Sözer, Hasan; Aksit, Mehmet; Havinga, W.K.

    2011-01-01

    Exception handling alters the control flow of the program. As such, errors introduced in exception handling code may influence the overall program in undesired ways. To detect such errors early and thereby decrease the programming costs, it is worthwhile to consider exception handling at design

  8. Robot Control Using UML and Multi-agent System

    Directory of Open Access Journals (Sweden)

    Ales Pavliska

    2003-02-01

    Full Text Available Increased industrialization and new markets have led to an accumulation of used technical consumer goods, which results in greater exploitation of raw materials, energy and landfill sites. In order to reduce the use of natural resources conserve precious energy and limit the increase in waste volume. The application of disassembly techniques is the first step towards this prevention of waste. These techniques form a reliable and clean approach: "noble" or high-graded recycling. This paper presents a multi agent system for disassembly process, which is implemented in a computer-aided application for supervising of the disassembling system: the Interactive Intelligent Interface for Disassembling System. Unified modeling language diagrams are used for an internal and external definition of the disassembling system.

  9. Generation of safe optimised execution strategies for uml models

    DEFF Research Database (Denmark)

    Herbert, Luke Thomas; Herbert-Hansen, Zaza Nadja Lee

    When designing safety critical systems there is a need for verification of safety properties while ensuring system operations have a specific performance profile. We present a novel application of model checking to derive execution strategies, sequences of decisions at workflow branch points...... which optimise a set of reward variables, while simultaneously observing constraints which encode any required safety properties and accounting for the underlying stochastic nature of the system. By evaluating quantitative properties of the generated adversaries we are able to construct an execution...

  10. UML Statechart Fault Tree Generation By Model Checking

    DEFF Research Database (Denmark)

    Herbert, Luke Thomas; Herbert-Hansen, Zaza Nadja Lee

    of the popular Business Process Modelling and Nota-tion (BPMN) language. To capture uncertainty and unreliability in workflows, we extend this formalism with probabilistic non-deterministic branching.We present an algorithm that allows for exhaustive gen-eration of possible error states that could arise in ex...

  11. On the impact of layout quality to understanding UML diagrams

    DEFF Research Database (Denmark)

    Störrle, Harald

    2011-01-01

    previous research considered them in isolation only. In this paper, we report the results of a series of controlled experiments using compound layouts on requirements analysis models. With very high significance, we find a notable impact of the layout quality measured by different aspects of cognitive load....

  12. A Note on Semantics (with an Emphasis on UML)

    OpenAIRE

    Rumpe, Bernhard

    2014-01-01

    Workshop themes: Business specifications are essential to describe and understand businesses (and, in particular, business rules) independently of any computing systems used for their possible automation. They have to express this understanding in a clear, precise, and explicit way, in order to act as a common ground between business domain experts and software developers. They also provide the basis for reuse of concepts and constructs ("patterns") common to all - from finance to telecommuni...

  13. Conception de bases de données avec UML

    CERN Document Server

    Roy, Gilles

    2007-01-01

    De l'analyse à la conception, cet ouvrage accorde une importance prédominante au modèle conceptuel de données et propose des règles, des techniques, des astuces et des mises en garde qui doivent guider le modélisateur dans la réalisation d'un bon modèle conceptuel.

  14. Requirements Validation: Execution of UML Models with CPN Tools

    DEFF Research Database (Denmark)

    Machado, Ricardo J.; Lassen, Kristian Bisgaard; Oliveira, Sérgio

    2007-01-01

    Requirements validation is a critical task in any engineering project. The confrontation of stakeholders with static requirements models is not enough, since stakeholders with non-computer science education are not able to discover all the inter-dependencies between the elicited requirements. Eve...... requirements, where the system to be built must explicitly support the interaction between people within a pervasive cooperative workflow execution. A case study from a real project is used to illustrate the proposed approach....

  15. Μελέτη και ανάπτυξη εκπαιδευτικού λογισμικού σε UML

    OpenAIRE

    Κουνάδη, Ιωάννα Σ.

    2011-01-01

    Η ανάπτυξη και εξάπλωση των τεχνολογιών πληροφορικής και επικοινωνιών (ΤΠΕ) δεν θα μπορούσε να αφήσει ανεπηρέαστο και τον χώρο της εκπαίδευσης κάθε είδους και βαθμίδας. Έτσι δημιουργήθηκε το εκπαιδευτικό λογισμικό (educational software) και η εκπαίδευση με χρήση υπολογιστή (computer driven education). Θέμα της πτυχιακής εργασίας είναι η ανάπτυξη ενός λογισμικού εκπαιδευτικού σκοπού, που θα αφορά της εκμάθησης της Unified Modelling Language (UML). Η εργασία ακολουθεί της εξής δόμηση: το 1ο κε...

  16. Using UML Modeling to Facilitate Three-Tier Architecture Projects in Software Engineering Courses

    Science.gov (United States)

    Mitra, Sandeep

    2014-01-01

    This article presents the use of a model-centric approach to facilitate software development projects conforming to the three-tier architecture in undergraduate software engineering courses. Many instructors intend that such projects create software applications for use by real-world customers. While it is important that the first version of these…

  17. Structural entities of an ontology-driven unifying metamodel for UML, EER, and ORM2

    CSIR Research Space (South Africa)

    Keet, CM

    2013-09-01

    Full Text Available , keet@ukzn.ac.za 2 Departamento de Ciencias e Ingenier´ıa de la Computacio´n, Universidad Nacional del Sur, Bah´ıa Blanca, Argentina, prf@cs.uns.edu.ar 3Comisio´n de Investigaciones Cient´ıficas, Provincia de Buenos Aires, Argentina Abstract. Software...

  18. Embedded systems analysis and modeling with SysML, UML and AADL

    CERN Document Server

    Kordon, Fabrice; Canals , Agusti; Dohet , Alain

    2013-01-01

    Since the construction of the first embedded system in the 1960s, embedded systems have continued to spread. They provide a continually increasing number of services and are part of our daily life. The development of these systems is a difficult problem which does not yet have a global solution. Another difficulty is that systems are plunged into the real world, which is not discrete (as is generally understood in computing), but has a richness of behaviors which sometimes hinders the formulation of simplifying assumptions due to their generally autonomous nature and they must face possibly

  19. Interactive scalable condensation of reverse engineered UML class diagrams for software comprehension

    NARCIS (Netherlands)

    Osman, Mohd Hafeez Bin

    2015-01-01

    Software design documentation is a valuable aid in software comprehension. However, keeping the software design up-to-date with evolving source code is challenging and time-consuming. Reverse engineering is one of the options for recovering software architecture from the implementation code.

  20. An investigation of difficulties experienced by students developing unified modelling language (UML) class and sequence diagrams

    Science.gov (United States)

    Sien, Ven Yu

    2011-12-01

    Object-oriented analysis and design (OOAD) is not an easy subject to learn. There are many challenges confronting students when studying OOAD. Students have particular difficulty abstracting real-world problems within the context of OOAD. They are unable to effectively build object-oriented (OO) models from the problem domain because they essentially do not know "what" to model. This article investigates the difficulties and misconceptions undergraduate students have with analysing systems using unified modelling language analysis class and sequence diagrams. These models were chosen because they represent important static and dynamic aspects of the software system under development. The results of this study will help students produce effective OO models, and facilitate software engineering lecturers design learning materials and approaches for introductory OOAD courses.

  1. Modeling emergency management data by UML as an extension of geographic data sharing model: ASAT approach

    NARCIS (Netherlands)

    Aydinoglu, Arif Cagdas; Yomralioglu, Tashin; Quak, Wilko; Dilo, Arta; Sahin, M.; Drager, K.H.

    2009-01-01

    Applying GIS functionality provides a powerful decision support in various application areas and the basis to integrate policies directed to citizens, business, and governments. The focus is changing toward integrating these functions to find optimal solutions to complex problems. As an integral

  2. Objectgeorienteerde domeinanalyse : Een systematische aanpak voor het ontwerp van UML-klassendiagrammen

    NARCIS (Netherlands)

    F.A.I. Peeters; drs. ir. J.F. Vonken

    2001-01-01

    Dit boek is bedoeld voor analisten van objectgeoriënteerde systemen en degenen die hiervoor in opleiding zijn. Maar het boek kan ook interessant zijn voor wie zich bezig houdt met informatiemodellering in het algemeen. Dit boek beschrijft de EXPO-methode (expression based object modeling) waarmee op

  3. Description of spatial data infrastructures (SDIs) using the Unified Modelling Language (UML)

    CSIR Research Space (South Africa)

    Cooper, Antony K

    2003-08-01

    Full Text Available ; boxshadowdwn Pay for something; boxshadowdwn Provide something; boxshadowdwn Invoice for something; boxshadowdwn Offer something; boxshadowdwn Service somebody; and boxshadowdwn Register something. All interactions should be described in text form... as scenarios of these interactions. Table 1: Interactions between an SDI and actors. No. Name Interaction Ia End user barb2right SDI - ask for metadata - ask for data - ask for services - ask for integrated services - ask for standards - pay...

  4. Transformation of UML models to CSP : a case study for graph transformation tools

    NARCIS (Netherlands)

    Varró, D.; Asztalos, M.; Bisztray, D.; Boronat, A.; Dang, D.; Geiß, R.; Greenyer, J.; Van Gorp, P.M.E.; Kniemeyer, O.; Narayanan, A.; Rencis, E.; Weinell, E.; Schürr, A.; Nagl, M.; Zündorf, A.

    2008-01-01

    Graph transformation provides an intuitive mechanism for capturing model transformations. In the current paper, we investigate and compare various graph transformation tools using a compact practical model transformation case study carried out as part of the AGTIVE 2007 Tool Contest [22]. The aim of

  5. Model-Based Requirements Analysis for Reactive Systems with UML Sequence Diagrams and Coloured Petri Nets

    DEFF Research Database (Denmark)

    Tjell, Simon; Lassen, Kristian Bisgaard

    2008-01-01

    In this paper, we describe a formal foundation for a specialized approach to automatically checking traces against real-time requirements. The traces are obtained from simulation of Coloured Petri Net (CPN) models of reactive systems. The real-time requirements are expressed in terms of a derivat...

  6. A UML/OCL framework for design of mediated data federations

    NARCIS (Netherlands)

    Balsters, H.

    2003-01-01

    This paper describes a general semantic framework for precise specification of so-called mediating systems; such systems provide for tight coupling on a global level of a collection of heterogeneous component databases to a federated database. A mediating system maps in a uniform and systematic

  7. Object-oriented analysis and design for information systems Modeling with UML, OCL, IFML

    CERN Document Server

    Wazlawick, Raul Sidnei

    2014-01-01

    Object-Oriented Analysis and Design for Information Systems clearly explains real object-oriented programming in practice. Expert author Raul Sidnei Wazlawick explains concepts such as object responsibility, visibility and the real need for delegation in detail. The object-oriented code generated by using these concepts in a systematic way is concise, organized and reusable. The patterns and solutions presented in this book are based in research and industrial applications. You will come away with clarity regarding processes and use cases and a clear understand of how to expand a use case.

  8. Modeling views in the layered view model for XML using UML

    NARCIS (Netherlands)

    Rajugan, R.; Dillon, T.S.; Chang, E.; Feng, L.

    In data engineering, view formalisms are used to provide flexibility to users and user applications by allowing them to extract and elaborate data from the stored data sources. Conversely, since the introduction of Extensible Markup Language (XML), it is fast emerging as the dominant standard for

  9. An Investigation of Difficulties Experienced by Students Developing Unified Modelling Language (UML) Class and Sequence Diagrams

    Science.gov (United States)

    Sien, Ven Yu

    2011-01-01

    Object-oriented analysis and design (OOAD) is not an easy subject to learn. There are many challenges confronting students when studying OOAD. Students have particular difficulty abstracting real-world problems within the context of OOAD. They are unable to effectively build object-oriented (OO) models from the problem domain because they…

  10. Toward an ontology-driven unifying metamodel for UML Class Diagrams, EER, & ORM2

    CSIR Research Space (South Africa)

    Keet, CM

    2013-11-01

    Full Text Available , Statistics, and Computer Science, University of KwaZulu-Natal and UKZN/CSIR-Meraka Centre for Artificial Intelligence Research, South Africa, keet@ukzn.ac.za 2 Departamento de Ciencias e Ingenieria de la Computacion, Universidad Nacional del Sur, Bahia...

  11. Making sense to modelers: Presenting UML class model differences in prose

    DEFF Research Database (Denmark)

    Störrle, Harald

    2013-01-01

    Understanding the difference between two models, such as different versions of a design, can be difficult. It is a commonly held belief in the model differencing community that the best way of presenting a model difference is by using graph or tree-based visualizations. We disagree and present an...... by a controlled experiment that tests three alternatives to presenting model differences. Our findings support our claim that the approach presented here is superior to EMF Compare.......Understanding the difference between two models, such as different versions of a design, can be difficult. It is a commonly held belief in the model differencing community that the best way of presenting a model difference is by using graph or tree-based visualizations. We disagree and present...... an alternative approach where sets of low-level model differences are abstracted into high-level model differences that lend themselves to being presented textually. This format is informed by an explorative survey to elicit the change descriptions modelers use themselves. Our approach is validated...

  12. Experiences and Comparison Study of EPC & UML For Business Process & IS Modeling

    OpenAIRE

    Md. Rashedul Islam; Md. Rofiqul Islam; Md. Shariful Alam; Md. Shafiul Azam

    2011-01-01

    Business process modeling is an approach by which we can analyze and integrate the business process. Using the Business Process Modeling we can represent the current and future process of a business/organization/enterprise. The business process modeling is a prerequisite and essential implementing a business or making any automation system. In this paper, we present our experience in a Business Process Modeling for organization. This paper presents detailed description about business process ...

  13. Insulin glargine 300 U/ml in the management of diabetes: clinical utility and patient perspectives

    Directory of Open Access Journals (Sweden)

    de Galan BE

    2016-10-01

    Full Text Available Bastiaan E de Galan Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands Abstract: There is ongoing interest in optimizing basal insulin treatment by developing insulins with a flat pharmacological profile, a long duration of action (typically beyond 24 hours and minimum day-to-day variation. Glargine-300 is a modified form of the long-acting insulin analog glargine in that it has been concentrated at 300 units/mL rather than the conventional 100 units/mL. Glargine-300 has a longer duration of action and a flatter pharmacological profile than original glargine-100. This property allows for more flexibility around the timing of administration, when injected once per day. Open-label studies in patients with diabetes have shown that treatment with glargine-300 achieves comparable glycemic control compared to treatment with glargine-100, albeit with consistently higher insulin requirements. These studies also showed that treatment with glargine-300 was associated with lower risks of nocturnal hypoglycemia in patients with type 2 diabetes, particularly those already on insulin, whereas data are mixed in insulin-naïve patients with type 2 diabetes or in patients with type 1 diabetes. Treatment with glargine-300 did not appear to affect the risk of overall hypoglycemia, whereas studies lacked sufficient power to investigate the effect on the risk of severe hypoglycemia. Future studies need to establish the role of glargine-300 in the treatment of diabetes alongside the other new long-acting insulin analog, insulin degludec, which was recently introduced to the market. Keywords: insulin glargine-300, type 1 diabetes, type 2 diabetes, hypoglycemia, HbA1c, patient-reported outcomes

  14. On the Design and Development of a UML-Based Visual Environment for Novice Programmers

    Science.gov (United States)

    Moor, Brian D.; Deek, Fadi P.

    2006-01-01

    Few beginners find learning to program easy. There are many factors at work in this phenomenon with some being simply inherent in the subject itself, while others have more to do with deficiencies in learning methods and resources. As a result, many programming environments, software applications, and learning tools have been developed to address…

  15. GENERACIÓN DEL DIAGRAMA DE SECUENCIAS DE UML 2.1.1 DESDE ESQUEMAS PRECONCEPTUALES GENERATION OF UML 2.1.1 SEQUENCE DIAGRAM FROM PRE-CONCEPTUAL SCHEMES

    Directory of Open Access Journals (Sweden)

    Carlos Mario Zapata

    2008-12-01

    Full Text Available El diagrama de secuencias es un esquema conceptual que permite representar el comportamiento de un sistema, para lo cual emplea la especificación de los objetos que se encuentran en un escenario y la secuencia de mensajes intercambiados entre ellos, con el fin de llevar a cabo una transacción del sistema. Existen diferentes enfoques que buscan la generación automática de modelos conceptuales, como el diagrama de secuencias. Algunos trabajos parten del lenguaje natural, pero generan diagramas diferentes al de secuencias o, si lo hacen igual, dejan de lado elementos como los fragmentos combinados, que describen ciertas condiciones lógicas en el sistema. Otros trabajos parten del código fuente, el cual se suele ubicar en una fase más avanzada del ciclo de vida del software. En este artículo se define un método, basado en reglas heurísticas, que permite identificar los elementos del diagrama de secuencias, incluyendo los fragmentos combinados, tomando como punto de partida los esquemas preconceptuales. Se realiza la implementación de las reglas en la herramienta AToM³ aplicándolas a un caso de estudio.Sequence diagram is a conceptual schema for representing behavior of a system. For performing such a task, it employs the object spec from a scenario and the sequence of messages exchanged among the objects. These elements describe a transaction of the system. Several approaches try the automated generation of conceptual models (like sequence diagram. Some of them use natural language as a starting point, but they are focused on other diagrams. Some others are focused on sequence diagram, but they do not obtain elements like combined fragments describing several logical constraints of the system. Other approaches use source code as a starting point, but source code can be related to an advanced phase of the software development life cycle. In this paper we define a method based on heuristic rules for obtaining automatically the elements of the sequence diagram (including combined fragments from pre-conceptual schemas. These heuristic rules are implemented in the AToM³ tool and applied in a case study.

  16. Using a Combination of UML, C2RM, XML, and Metadata Registries to Support Long-Term Development/Engineering

    Science.gov (United States)

    2003-01-01

    Authenticat’n (XCBF) Authorizat’n (XACML) (SAML) Privacy (P3P) Digital Rights Management (XrML) Content Mngmnt (DASL) (WebDAV) Content Syndicat’n...Registry/ Repository BPSS eCommerce XML/EDI Universal Business Language (UBL) Internet & Computing Human Resources (HR-XML) Semantic KEY XML SPECIFICATIONS

  17. From UML to process algebra and back : an automated approach to model-checking software design artifacts of concurrent systems

    NARCIS (Netherlands)

    Remenska, D.; Templon, J.A.; Willemse, T.A.C.; Homburg, P.; Verstoep, K.; Casajus, A.; Bal, H.E.; Brat, G.; Rungta, N.; Venet, A.

    2013-01-01

    One of the challenges in concurrent software development is early discovery of design errors which could lead to deadlocks or race-conditions. For safety-critical and complex distributed applications, traditional testing does not always expose such problems. Performing more rigorous formal analysis

  18. An UML Statechart Diagram-Based MM-Path Generation Approach for Object-Oriented Integration Testing

    OpenAIRE

    Ruilian Zhao; Ling Lin

    2008-01-01

    MM-Path, an acronym for Method/Message Path, describes the dynamic interactions between methods in object-oriented systems. This paper discusses the classifications of MM-Path, based on the characteristics of object-oriented software. We categorize it according to the generation reasons, the effect scope and the composition of MM-Path. A formalized representation of MM-Path is also proposed, which has considered the influence of state on response method sequences of messages. .Moreover, an au...

  19. SysML Model of the Pick and Place Unit for Papyrus UML: Scenario Sc4b

    OpenAIRE

    Vogel-Heuser, Birgit; Folmer, Jens; Legat, Christoph

    2014-01-01

    The Pick and Place Unit (PPU) is a bench-scale lab demonstrator which is open to the research community to investigate a variety of different topics. To conduct research on the evolution of production automation systems, a variety of different manifestations of the PPU (referred to as scenarios) were developed. A documentation of the PPU and its scenarios is publicly available at www.ppu-demonstrator.org. In this zipped file, a SysML model consisting of state charts and block definition diagr...

  20. Insulin glargine 300 U/mL for basal insulin therapy in type 1 and type 2 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Lau IT

    2017-06-01

    Full Text Available Ip Tim Lau,1 Ka Fai Lee,2 Wing Yee So,3 Kathryn Tan,4 Vincent Tok Fai Yeung5 1Department of Medicine, Tseung Kwan O Hospital, 2Department of Medicine and Geriatrics, Kwong Wah Hospital, 3Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, 4Department of Medicine, Queen Mary Hospital, University of Hong Kong, 5Department of Medicine and Geriatrics, Our Lady of Maryknoll Hospital, Hong Kong, China Objective: To review published clinical studies on the efficacy and safety of new insulin glargine 300 units/mL (Gla-300, a new long-acting insulin analog, for the treatment of type 1 and type 2 diabetes mellitus (T1DM, T2DMMaterials and methods: Data sources comprised primary research articles on Gla-300, including pharmacodynamic, pharmacokinetic, and clinical studies.Results: In pharmacodynamic and pharmacokinetic studies, Gla-300 showed a flatter time–action profile and longer duration of action than Gla-100. Noninferiority of Gla-300 versus Gla-100 for lowering of glycated hemoglobin was demonstrated in Phase III clinical studies covering a range of T1DM and T2DM patient populations. Over 6–12 months of follow-up, Gla-300 consistently showed comparable glycemic efficacy with less hypoglycemia vs Gla-100, even during the first 8 weeks of treatment. Although titrated insulin doses were 11%–17% higher with Gla-300 vs Gla-100, changes in body weight were similar or favored Gla-300.Conclusion: Clinical studies provide evidence that the pharmacodynamic and pharmacokinetic properties of Gla-300 may translate into clinical benefits in both T1DM and T2DM. Gla-300 may provide a new option for people initiating basal insulin, those requiring higher basal insulin doses, those with T1DM, and those who may be at increased risk for hypoglycemia, such as people with chronic kidney disease, the elderly, and those with cardiovascular comorbidities. Keywords: diabetes mellitus, long-acting insulin, insulin glargine

  1. Insulin glargine 300 U/mL in the management of diabetes: clinical utility and patient perspectives

    NARCIS (Netherlands)

    Galan, B.E. de

    2016-01-01

    There is ongoing interest in optimizing basal insulin treatment by developing insulins with a flat pharmacological profile, a long duration of action (typically beyond 24 hours) and minimum day-to-day variation. Glargine-300 is a modified form of the long-acting insulin analog glargine in that it

  2. caCORE version 3: Implementation of a model driven, service-oriented architecture for semantic interoperability

    OpenAIRE

    Komatsoulis, George A.; Warzel, Denise B.; Hartel, Frank W.; Shanbhag, Krishnakant; Chilukuri, Ram; Fragoso, Gilberto; de Coronado, Sherri; Reeves, Dianne M.; Hadfield, Jillaine B.; Ludet, Christophe; Covitz, Peter A.

    2007-01-01

    One of the requirements for a federated information system is interoperability, the ability of one computer system to access and use the resources of another system. This feature is particularly important in biomedical research systems, which need to coordinate a variety of disparate types of data. In order to meet this need, the National Cancer Institute Center for Bioinformatics (NCICB) has created the cancer Common Ontologic Representation Environment (caCORE), an interoperability infrastr...

  3. The Best of All Possible Worlds: Applying the Model Driven Architecture Approach to a JC3IEDM OWL Ontology Modeled in UML

    Science.gov (United States)

    2014-06-01

    from the ODM standard. Leveraging SPARX EA’s Java application programming interface (API), the team built a tool called OWL2EA that can ingest an OWL...server MySQL creates the physical schema that enables a user to store and retrieve data conforming to the vocabulary of the JC3IEDM. 6. GENERATING AN

  4. Hygroscopicity of secondary organic aerosols formed by oxidation of cycloalkenes, monoterpenes, sesquiterpenes, and related compounds

    Directory of Open Access Journals (Sweden)

    V. Varutbangkul

    2006-01-01

    Full Text Available A series of experiments has been conducted in the Caltech indoor smog chamber facility to investigate the water uptake properties of aerosol formed by oxidation of various organic precursors. Secondary organic aerosol (SOA from simple and substituted cycloalkenes (C5-C8 is produced in dark ozonolysis experiments in a dry chamber (RH~5%. Biogenic SOA from monoterpenes, sesquiterpenes, and oxygenated terpenes is formed by photooxidation in a humid chamber (~50% RH. Using the hygroscopicity tandem differential mobility analyzer (HTDMA, we measure the diameter-based hygroscopic growth factor (GF of the SOA as a function of time and relative humidity. All SOA studied is found to be slightly hygroscopic, with smaller water uptake than that of typical inorganic aerosol substances. The aerosol water uptake increases with time early in the experiments for the cycloalkene SOA, but decreases with time for the sesquiterpene SOA. This behavior could indicate competing effects between the formation of more highly oxidized polar compounds (more hygroscopic, and formation of longer-chained oligomers (less hygroscopic. All SOA also exhibit a smooth water uptake with RH with no deliquescence or efflorescence. The water uptake curves are found to be fitted well with an empirical three-parameter functional form. The measured pure organic GF values at 85% RH are between 1.09–1.16 for SOA from ozonolysis of cycloalkenes, 1.01–1.04 for sesquiterpene photooxidation SOA, and 1.06–1.10 for the monoterpene and oxygenated terpene SOA. The GF of pure SOA (GForg in experiments in which inorganic seed aerosol is used is determined by assuming volume-weighted water uptake (Zdanovskii-Stokes-Robinson or 'ZSR' approach and using the size-resolved organic mass fraction measured by the Aerodyne Aerosol Mass Spectrometer. Knowing the water content associated with the inorganic fraction yields GForg values. However, for each precursor, the GForg values computed from different

  5. caCORE: a common infrastructure for cancer informatics.

    Science.gov (United States)

    Covitz, Peter A; Hartel, Frank; Schaefer, Carl; De Coronado, Sherri; Fragoso, Gilberto; Sahni, Himanso; Gustafson, Scott; Buetow, Kenneth H

    2003-12-12

    Sites with substantive bioinformatics operations are challenged to build data processing and delivery infrastructure that provides reliable access and enables data integration. Locally generated data must be processed and stored such that relationships to external data sources can be presented. Consistency and comparability across data sets requires annotation with controlled vocabularies and, further, metadata standards for data representation. Programmatic access to the processed data should be supported to ensure the maximum possible value is extracted. Confronted with these challenges at the National Cancer Institute Center for Bioinformatics, we decided to develop a robust infrastructure for data management and integration that supports advanced biomedical applications. We have developed an interconnected set of software and services called caCORE. Enterprise Vocabulary Services (EVS) provide controlled vocabulary, dictionary and thesaurus services. The Cancer Data Standards Repository (caDSR) provides a metadata registry for common data elements. Cancer Bioinformatics Infrastructure Objects (caBIO) implements an object-oriented model of the biomedical domain and provides Java, Simple Object Access Protocol and HTTP-XML application programming interfaces. caCORE has been used to develop scientific applications that bring together data from distinct genomic and clinical science sources. caCORE downloads and web interfaces can be accessed from links on the caCORE web site (http://ncicb.nci.nih.gov/core). caBIO software is distributed under an open source license that permits unrestricted academic and commercial use. Vocabulary and metadata content in the EVS and caDSR, respectively, is similarly unrestricted, and is available through web applications and FTP downloads. http://ncicb.nci.nih.gov/core/publications contains links to the caBIO 1.0 class diagram and the caCORE 1.0 Technical Guide, which provide detailed information on the present caCORE architecture

  6. Analyse des causes d'échec des projets d'affaires à partir d'études de cas en entreprises, et proposition d'un modèle de domaine en langage UML

    OpenAIRE

    Wong , Siaw Ming

    2010-01-01

    Despite the efforts to improve the maturity of the project management profession, the failure rate of business projects remains high. It was realized that current project management standards do not take contextual requirements into consideration and business project management really has not been addressed in totality. The purpose of this interdisciplinary study therefore, is to obtain a better understanding of the subject matter by investigating why business project fails from the organizat...

  7. Mission Assurance in a Distributed Environment

    Science.gov (United States)

    2009-06-01

    Notation ( BPMN ) – Graphical representation of business processes in a workflow • Unified Modeling Language (UML) – Use standard UML diagrams to model the system – Component, sequence, activity diagrams

  8. [caCORE: core architecture of bioinformation on cancer research in America].

    Science.gov (United States)

    Gao, Qin; Zhang, Yan-lei; Xie, Zhi-yun; Zhang, Qi-peng; Hu, Zhang-zhi

    2006-04-18

    A critical factor in the advancement of biomedical research is the ease with which data can be integrated, redistributed and analyzed both within and across domains. This paper summarizes the Biomedical Information Core Infrastructure built by National Cancer Institute Center for Bioinformatics in America (NCICB). The main product from the Core Infrastructure is caCORE--cancer Common Ontologic Reference Environment, which is the infrastructure backbone supporting data management and application development at NCICB. The paper explains the structure and function of caCORE: (1) Enterprise Vocabulary Services (EVS). They provide controlled vocabulary, dictionary and thesaurus services, and EVS produces the NCI Thesaurus and the NCI Metathesaurus; (2) The Cancer Data Standards Repository (caDSR). It provides a metadata registry for common data elements. (3) Cancer Bioinformatics Infrastructure Objects (caBIO). They provide Java, Simple Object Access Protocol and HTTP-XML application programming interfaces. The vision for caCORE is to provide a common data management framework that will support the consistency, clarity, and comparability of biomedical research data and information. In addition to providing facilities for data management and redistribution, caCORE helps solve problems of data integration. All NCICB-developed caCORE components are distributed under open-source licenses that support unrestricted usage by both non-profit and commercial entities, and caCORE has laid the foundation for a number of scientific and clinical applications. Based on it, the paper expounds caCORE-base applications simply in several NCI projects, of which one is CMAP (Cancer Molecular Analysis Project), and the other is caBIG (Cancer Biomedical Informatics Grid). In the end, the paper also gives good prospects of caCORE, and while caCORE was born out of the needs of the cancer research community, it is intended to serve as a general resource. Cancer research has historically

  9. Strain improvement in dye decolourising mutants of Mucor mucedo ...

    African Journals Online (AJOL)

    The fusant MMFu3 showed very good increase in the production of three enzymes protease (1.90 U/ml), peroxidase (1100 U/ml) and laccase (200 U/ml) when compared to the two parent strains proving that the higher enzymatic secretions are responsible for the decolourisation activity. In protease isozyme analysis, fusants ...

  10. Model-driven dependability assessment of software systems

    CERN Document Server

    Bernardi, Simona; Petriu, Dorina C

    2013-01-01

    In this book, the authors present cutting-edge model-driven techniques for modeling and analysis of software dependability. Most of them are based on the use of UML as software specification language. From the software system specification point of view, such techniques exploit the standard extension mechanisms of UML (i.e., UML profiling). UML profiles enable software engineers to add non-functional properties to the software model, in addition to the functional ones. The authors detail the state of the art on UML profile proposals for dependability specification and rigorously describe the t

  11. EKSPLORASI DAN IMPLEMENTASI UNIFIED APPROACH DALAM PERANCANGAN SISTEM INFORMASI : STUDI KASUS SISTEM RESERVASI HOTEL

    Directory of Open Access Journals (Sweden)

    Fajar Baskoro

    2002-07-01

    Full Text Available Perancangan perangkat lunak merupakan tahapan yang penting di dalam rekayasa perangkat lunak. Pemilihan perangkat perancangan yang dapat membantu memodelkan perangkat lunak menentukan kemudahan spesifikasi, implementasi, visualisasi, pengujian, dan dokumentasi perangkat lunak. UML, Unified Modelling Language sebagai Bahasa Pemodelan Terpadu mempunyai perangkat untuk memodelkan perangkat lunak memvisualisasikan use case, statis, dan perilaku perangkat lunak di dalam sistem. Penggunaan UML di dalam perancangan sistem informasi berbeda dengan penggunaan UML di dalam perangkat Lunak Waktu Nyata (Realtime. Pendekatan Unified adalah salah satu panduan yang digunakan untuk perancangan perangkat lunak dengan menggunakan UML. Kata kunci: UML, pendekatan unified, reservasi hotel.

  12. Towards Model Validation and Verification with SAT Techniques

    OpenAIRE

    Gogolla, Martin

    2010-01-01

    After sketching how system development and the UML (Unified Modeling Language) and the OCL (Object Constraint Language) are related, validation and verification with the tool USE (UML-based Specification Environment) is demonstrated. As a more efficient alternative for verification tasks, two approaches using SAT-based techniques are put forward: First, a direct encoding of UML and OCL with Boolean variables and propositional formulas, and second, an encoding employing an...

  13. UML-МОДЕЛЮВАННЯ ІНФОРМАЦІЙНО-АНАЛІТИЧНОЇ СИСТЕМИ “НАВЧАЛЬНИЙ ПЛАН”

    Directory of Open Access Journals (Sweden)

    Valerii G. Grytsenko

    2011-05-01

    Розроблені діаграми формують основу шаблону структури та зв’язків між елементами системи та дозволяють відслідковувати різні аспекти її поведінки. У подальшому, розроблена система може бути доповнена діаграмами для генерації коду.

  14. Toward a Model-Based Approach for Flight System Fault Protection

    Science.gov (United States)

    Day, John; Meakin, Peter; Murray, Alex

    2012-01-01

    Use SysML/UML to describe the physical structure of the system This part of the model would be shared with other teams - FS Systems Engineering, Planning & Execution, V&V, Operations, etc., in an integrated model-based engineering environment Use the UML Profile mechanism, defining Stereotypes to precisely express the concepts of the FP domain This extends the UML/SysML languages to contain our FP concepts Use UML/SysML, along with our profile, to capture FP concepts and relationships in the model Generate typical FP engineering products (the FMECA, Fault Tree, MRD, V&V Matrices)

  15. Effect of different growth parameters on chitinase enzyme activity ...

    African Journals Online (AJOL)

    Optimization of culture conditions revealed that the enzyme production was maximum in pH 7.5 (107.4 ± 0.50 U/ml), temperature 35°C (103.15 ± 1.74 U/ml) when the carbon and the nitrogen sources used were CMC (106.0 ± 1.89 U/ml) and KNO3 (91.2 ± 1.51 U/ml), respectively. The total chitinase production for all optimum ...

  16. Different agroresidues used in solid substrate fermentation for alpha- amylase production by bacillus subtilis-329

    International Nuclear Information System (INIS)

    Yousaf, M.; Bhatty, M.B.; Nadeem, M.; Nasreen, Z.

    2008-01-01

    The best mass ratio for agroresidue fermentation for a-amylase production by locally isolated Bacillus subtilis-239 was found to be wheat bran to rice bran 2:1 with 70% initial moisture content for 60 h incubation time. Among different inorganic nitrogen sources supplemented, sodium nitrate and ammonium chloride (0.5% w/w) increased the enzyme yield upto 178 U/ml and 176 U/ml, respectively, whereas all the organic nitrogen sources decreased the enzyme production. Addition of glucose (1% w/w) as a carbon source enhanced a-amylase synthesis to 185 U/ml as compared to the control (134 U/ml). (author)

  17. End-to-end integrated security and performance analysis on the DEGAS Choreographer platform

    DEFF Research Database (Denmark)

    Buchholtz, Mikael; Gilmore, Stephen; Haenel, Valentin

    2005-01-01

    We present a software tool platform which facilitates security and performance analysis of systems which starts and ends with UML model descriptions. A UML project is presented to the platform for analysis, formal content is extracted in the form of process calculi descriptions, analysed with the......We present a software tool platform which facilitates security and performance analysis of systems which starts and ends with UML model descriptions. A UML project is presented to the platform for analysis, formal content is extracted in the form of process calculi descriptions, analysed...

  18. Production of rennin-like acid protease by Mucor pusillus through submerged fermentation

    International Nuclear Information System (INIS)

    Daudi, S.; Mukhtar, H.; Rehman, A.U.; Haq, I.U.

    2015-01-01

    The present study is concerned with the isolation and screening of Mucor species for the production of acid protease in shake flasks. Out of eight mould cultures evaluated, five were isolated from soil and three were provided from the Institute of Industrial Biotechnology, Government College University, Lahore. Of all the isolates tested, Mucor pusillus IHS6 was found to be the best producer of rennin-like acid protease producing 75 U/ml of the enzyme. Different agricultural byproducts were evaluated as fermentation substrates and maximum enzyme synthesis (61 U/ml) was obtained when rapeseed meal was used as a substrate. Optimum pH and fermentation period for the production of protease were 5.5 (56U/ml) and 72 hrs (55U/ml), respectively. The production of protease by Mucor pusillus IHS6 was also studied by adding different carbon and nitrogen sources to the fermentation medium. Fructose at a concentration of 1.5% (66 U/ml) and yeast extract at a concentration of 2% (68.2 U/ml) and ammonium chloride at a concentration of 0.1% (67U/ml) were found to be the best carbon and nitrogen (organic and inorganic) sources respectively. Spore inoculum at a concentration of 1% (68.4 U/ml) was found to be the best for protease production by Mucor pusillus. The fermentation broth was found to have strong milk clotting activity with 200 RU. (author)

  19. Optimized Production of Lignin Peroxidase, Manganese Peroxidase

    African Journals Online (AJOL)

    Mgina

    submerged culture fermentations were investigated for maximum enzymes ... 0.18, 4.44 and 593 U/ml, respectively compared to 0.0011, 0.0054 and 2.3 U/ml .... (2004) studied some Tanzanian white rot ... were done in 500 ml Erlenmeyer flasks and ... rotary shaker at 125 rpm. ..... bioreactor cultures (Hess et al., 2002). From.

  20. Optimization of Cellulase and Xylanase Production by Micrococcus Species under Submerged Fermentation

    Directory of Open Access Journals (Sweden)

    Ziyanda Mmango-Kaseke

    2016-11-01

    Full Text Available This paper reports on the optimization of culture conditions for cellulase and xylanase production by bacterial isolate from lignocellulosic biomass. The bacterial isolate was screened for cellulase and xylanase production on carboxyl methyl cellulose (CMC and birch wood xylan as substrates, respectively. One bacterial isolate showing the highest halo zone diameter (isolate PLY1 was selected for detailed studies. The analysis of the 16S ribosomal ribonucleic acid (rRNA gene nucleotide sequence of PLY1 revealed it to have 98% similarity to Micrococcus luteus strain Fse9 and the sequence was deposited in the GenBank as Micrococcus luteus strain SAMRC-UFH3 with accession number KU171371. Cellulase production was achieved in the presence of CMC (1% w/v under an incubation temperature of 25 °C (198 U/mL, pH 5 (173 U/mL, agitation speed 50 rpm (173 U/mL and incubation period of 96 h (102 U/mL. Xylanase was produced maximally when birch wood xylan (1% w/v was used as the substrate at 25 °C (1007 U/mL, pH 10 (2487 U/mL, 200 rpm (1814 U/mL, and under an incubation period of 84 h (1296 U/mL. Our findings showed that Micrococcus sp. SAMRC-UFH3 appears to be a potentially important candidate for lignocellulosic waste degradation and other relevant industrial applications.

  1. Use Case Modelling of Bingham University Library Management ...

    African Journals Online (AJOL)

    With the advent of object oriented design, Unified Modelling Language (UML) has become prominent in software industry. Software is better modelled with the use of UML diagrams like use cases which provide a better flow of logic and comprehensive summary of the whole software system in a single illustration.

  2. A Software Hub for High Assurance Model-Driven Development and Analysis

    Science.gov (United States)

    2007-01-23

    verification of UML models in TLPVS. In Thomas Baar, Alfred Strohmeier, Ana Moreira, and Stephen J. Mellor, editors, UML 2004 - The Unified Modeling...volume 3785 of Lecture Notes in Computer Science, pages 52–65, Manchester, UK, Nov 2005. Springer. [GH04] Günter Graw and Peter Herrmann. Transformation

  3. Tool Support for Collaborative Teaching and Learning of Object-Oriented Modelling

    DEFF Research Database (Denmark)

    Hansen, Klaus Marius; Ratzer, Anne Vinter

    2002-01-01

    Modeling is central to doing and learning object-oriented development. We present a new tool, Ideogramic UML, for gesture-based collaborative modeling with the Unified Modeling Language (UML), which can be used to collaboratively teach and learn modeling. Furthermore, we discuss how we have...

  4. Effects of Pretreatment of Single and Mixed Lignocellulosic Substrates on Production of Endoglucanase by Bacillus aerius S5.2

    Directory of Open Access Journals (Sweden)

    Mushafau Adebayo Oke

    2016-06-01

    Full Text Available A mixed substrate (MS comprising oil palm empty fruit bunch (EFB, oil palm frond (OPF, and rice husk (RH was evaluated for endoglucanase production by Bacillus aerius S5.2. Effects of sulphuric acid, sodium hydroxide, N-methylmorpholine-N-oxide (NMMO, and hydrothermal pretreatments on endoglucanase production were investigated. Endoglucanase production by B. aerius on the untreated (0.677 U/mL and pretreated MS (0.305 – 0.630 U/mL was generally similar, except that the acid (0.305 U/mL and hydrothermal (0.549 U/mL pretreatments that were more severe consequently produced significantly lower titres. Alkali pretreatment supported the highest enzyme production (0.630 U/mL among all pretreatments that were studied. When endoglucanase production on the alkali-pretreated MS and single substrates (SS was compared, alkali-pretreated EFB produced a titre (0.655 U/mL similar to the MS, and this was significantly higher than titres recorded on OPF (0.504 U/mL and RH (0.525 U/mL. Lower enzyme production was found to be consistent with higher pretreatment severity and greater removal of amorphous regions in all the pretreatments. Furthermore, combining the SS showed no adverse effects on endoglucanase production.

  5. Examination of Modeling Languages to Allow Quantitative Analysis for Model-Based Systems Engineering

    Science.gov (United States)

    2014-06-01

    System Operation ...............37 Figure 15. UML/SysML Datatype Diagram .....................................................................40...SysML has non-normative guidance on defining random variable datatypes but does not provide any guidance on how to handle random variables that are...normative guidance for properties without fixed values. The UML Datatype Diagram, shown in Figure 15. does support defining properties with a

  6. ФОРМАЛЬНІ МЕТОДИ ПОБУДОВИ ДІАГРАМ ЛОГІСТИЧНИХ БІЗНЕС-ПРОЦЕСІВ

    Directory of Open Access Journals (Sweden)

    О. В. Мелентьєва

    2016-12-01

    Full Text Available This article considers the main methods of the description and creation of charts of business processes. The main methods are the notation of BPMN, languages of the description of BPEL and UML, methodologies of IDEF and ARIS. In article the main characteristic features inherent of methodologies of IDEF0 and IDEF3, the UML language have been in detail considered and analysed. The UML language is considered rather young therefore it is used more often. It is most often applied to modeling of object-oriented systems. On the example of application of creation of the chart of activities (actions the UML language represents a wide choice of elements of the embodiment of idea. As the same process can be provided in various forms. IDEF respectively more mature methodology. IDEF methodology, unlike the UML language, is limited to such choice, it has accurately certain rules of representation of process. With the IDEF technology carry IDEF0 and IDEF3 and it methods are most applied. In this article are provided examples of application of the UML language and methodology of IDEF0. As an example has been provided a logistic supply chain of goods to the customer who has been ordered by means of online store. Thanks to graphical representation it is possible to draw a conclusion that it is more convenient to describe and create charts of processes on UML. Unlike IDEF0 the UML language possesses a big tool kit therefore also the chart looks more realistic.

  7. The Future of Architecture Collaborative Information Sharing: DoDAF Version 2.03 Updates

    Science.gov (United States)

    2012-04-30

    Salamander x Select Solution Factory Select Business Solutions BPMN , UML x SimonTool Simon Labs x SimProcess CACI BPMN x System Architecture Management...for DoDAF Mega UML x Metastorm ProVision Metastorm BPMN x Naval Simulation System - 4 Aces METRON x NetViz CA x OPNET OPNET x Tool Name Vendor Primary

  8. MACCIS 2.0 - An Architecture Description Framework for Technical Infostructures and Their Enterprise Environment

    Science.gov (United States)

    2004-06-01

    Frequencies Receive ARCADE data Generate Frequency list Receive frequency requirements from lower level Receive COP Establish/maintain frequency...pool temporary list : Frequencies Verify security level Distribute Frequency list Verify Frequency list new operation new campaign list...Frequencies new operation Distribute temporary Frequency list new campaign Joint LevelLower Echelon UnitCOPdistributorARCADE system UML Use Case Model UML

  9. Executable Design Models for a Pervasive Healthcare Middleware System

    DEFF Research Database (Denmark)

    Jørgensen, Jens Bæk; Christensen, Søren

    2002-01-01

     UML is applied in the design of a pervasive healthcare middleware system for the hospitals in Aarhus County, Denmark. It works well for the modelling of static aspects of the system, but with respect to describing the behaviour, UML is not sufficient. This paper explains why and, as a remedy, su...

  10. Enabling remote access to projects in a large collaborative environment

    International Nuclear Information System (INIS)

    Pais, V.F.; Balme, S.; Akpangny, H.S.; Iannone, F.; Strand, P.

    2010-01-01

    In the context of the Integrated Tokamak Modelling Task Force, a large number of software projects are made available to the task force members, including developers and end-users. This has been achieved through a combination of tools and technologies. The front-end is represented by a Java based portal system exposing a PHP project management system, GForge. These two applications are linked by a single sign-on mechanism, Shibboleth , and through secure HTTP request rewriting, where appropriate. Furthermore, the underlying storage facility is an OpenAFS distributed file system and the user base comes from both a network information server and an LDAP directory. Security mechanisms are those of a distributed system, with multiple access points and protocols used for reading and writing data. The present paper presents the challenges of integrating these different technologies and programming languages into a single, working, application presented to its users as a web portal. Chaining of the tools is explored through the user perspective, with an in-depth overview of the background transitions between the various systems involved with regard to security requirements for the front-end nodes and the policies as seen by the users.

  11. Enabling remote access to projects in a large collaborative environment

    Energy Technology Data Exchange (ETDEWEB)

    Pais, V. [INFLPR National Institute for Laser, Plasma and Radiation Physics, Magurele (Romania); Balme, S. [CEA Cadarache, IRFM, 13 - Saint-Paul-lez-Durance (France); Iannonec, F. [Associazione EURATOM-ENEA sulla Fusione, Frascati (Italy); Strand, P. [Department of Radio and Space Science, Chalmers University of Technology, Goteborg (Sweden)

    2009-07-01

    In the context of the Integrated Tokamak Modeling Task Force, a large number of software projects are made available to the task force members, including developers and end-users. This has been achieved through a combination of tools and technologies. The front-end is represented by a Java based portal system exposing a PHP project management system, Gforge. These two applications are linked by a single sign-on mechanism, Shibboleth, and through secure HTTP request rewriting, where appropriate. Furthermore, the underlying storage facility is an OpenAFS distributed file system and the user base comes from both a network information server and an LDAP directory. Security mechanisms are those of a distributed system, with multiple access points and protocols used for reading and writing data. This document presents the challenges of integrating these different technologies and programming languages into a single, working, application presented to its users as a web portal. The chaining of the tools is explored through the user perspective, with an in-depth overview of the background transitions between the various systems involved with regard to security requirements for the front-end nodes and the policies as seen by the users. This document is composed of a poster and its abstract. (authors)

  12. Enabling remote access to projects in a large collaborative environment

    Energy Technology Data Exchange (ETDEWEB)

    Pais, V.F., E-mail: pvf2005@gmail.co [Laser Department, National Institute for Laser, Plasma and Radiation Physics, P.O. Box MG-36, Bucharest 077125, Association EURATOM/MEdC (Romania); Balme, S.; Akpangny, H.S. [Association EURATOM CEA/IRFM CEA-Cadarache (France); Iannone, F. [Associazione EURATOM-ENEA sulla Fusione, C.R.ENEA Frascati, via E.Fermi 45, 00044 Frascati, Rome (Italy); Strand, P. [Department of Radio and Space Science, Chalmers University of Technology, SE-412 96 Goteborg (Sweden)

    2010-07-15

    In the context of the Integrated Tokamak Modelling Task Force, a large number of software projects are made available to the task force members, including developers and end-users. This has been achieved through a combination of tools and technologies. The front-end is represented by a Java based portal system exposing a PHP project management system, GForge. These two applications are linked by a single sign-on mechanism, Shibboleth , and through secure HTTP request rewriting, where appropriate. Furthermore, the underlying storage facility is an OpenAFS distributed file system and the user base comes from both a network information server and an LDAP directory. Security mechanisms are those of a distributed system, with multiple access points and protocols used for reading and writing data. The present paper presents the challenges of integrating these different technologies and programming languages into a single, working, application presented to its users as a web portal. Chaining of the tools is explored through the user perspective, with an in-depth overview of the background transitions between the various systems involved with regard to security requirements for the front-end nodes and the policies as seen by the users.

  13. Improved production of an enzyme that hydrolyses raw yam starch by Penicillium sp. S-22 using fed-batch fermentation.

    Science.gov (United States)

    Sun, Hai-Yan; Ge, Xiang-Yang; Zhang, Wei-Guo

    2006-11-01

    A newly isolated strain, Penicillium sp. S-22, was used to produce an enzyme that hydrolyses raw yam starch [raw yam starch digesting enzyme (RYSDE)]. The enzyme activity and overall enzyme productivity were respectively 16 U/ml and 0.19 U/ml h in the batch culture. The enzyme activity increased to 85 U/ml by feeding of partially hydrolyzed raw yam starch. When a mixture containing partially hydrolyzed raw yam starch and peptone was fed by a pH-stat strategy, the enzyme activity reached 366 U/ml, 23-fold of that obtained in the batch culture, and the overall productivity reached 3.4 U/ml h, which was 18-fold of that in the batch culture.

  14. A method of formal requirements analysis for NPP I and C systems based on object-oriented visual modeling with SCR

    International Nuclear Information System (INIS)

    Koo, S. R.; Seong, P. H.

    1999-01-01

    In this work, a formal requirements analysis method for Nuclear Power Plant (NPP) I and C systems is suggested. This method uses Unified Modeling Language (UML) for modeling systems visually and Software Cost Reduction (SCR) formalism for checking the system models. Since object-oriented method can analyze a document by the objects in a real system, UML models that use object-oriented method are useful for understanding problems and communicating with everyone involved in the project. In order to analyze the requirement more formally, SCR tabular notations is converted from UML models. To help flow-through from UML models to SCR specifications, additional syntactic extensions for UML notation and a converting procedure are defined. The combined method has been applied to Dynamic Safety System (DSS). From this application, three kinds of errors were detected in the existing DSS requirements

  15. The application of the unified modeling language in object-oriented analysis of healthcare information systems.

    Science.gov (United States)

    Aggarwal, Vinod

    2002-10-01

    This paper concerns itself with the beneficial effects of the Unified Modeling Language (UML), a nonproprietary object modeling standard, in specifying, visualizing, constructing, documenting, and communicating the model of a healthcare information system from the user's perspective. The author outlines the process of object-oriented analysis (OOA) using the UML and illustrates this with healthcare examples to demonstrate the practicality of application of the UML by healthcare personnel to real-world information system problems. The UML will accelerate advanced uses of object-orientation such as reuse technology, resulting in significantly higher software productivity. The UML is also applicable in the context of a component paradigm that promises to enhance the capabilities of healthcare information systems and simplify their management and maintenance.

  16. caCORE version 3: Implementation of a model driven, service-oriented architecture for semantic interoperability.

    Science.gov (United States)

    Komatsoulis, George A; Warzel, Denise B; Hartel, Francis W; Shanbhag, Krishnakant; Chilukuri, Ram; Fragoso, Gilberto; Coronado, Sherri de; Reeves, Dianne M; Hadfield, Jillaine B; Ludet, Christophe; Covitz, Peter A

    2008-02-01

    One of the requirements for a federated information system is interoperability, the ability of one computer system to access and use the resources of another system. This feature is particularly important in biomedical research systems, which need to coordinate a variety of disparate types of data. In order to meet this need, the National Cancer Institute Center for Bioinformatics (NCICB) has created the cancer Common Ontologic Representation Environment (caCORE), an interoperability infrastructure based on Model Driven Architecture. The caCORE infrastructure provides a mechanism to create interoperable biomedical information systems. Systems built using the caCORE paradigm address both aspects of interoperability: the ability to access data (syntactic interoperability) and understand the data once retrieved (semantic interoperability). This infrastructure consists of an integrated set of three major components: a controlled terminology service (Enterprise Vocabulary Services), a standards-based metadata repository (the cancer Data Standards Repository) and an information system with an Application Programming Interface (API) based on Domain Model Driven Architecture. This infrastructure is being leveraged to create a Semantic Service-Oriented Architecture (SSOA) for cancer research by the National Cancer Institute's cancer Biomedical Informatics Grid (caBIG).

  17. Usefulness of CA 130 kit based on IRMA

    International Nuclear Information System (INIS)

    Fujii, Takashi; Kimura, Yoshiko; Ata, Mariko; Miyagawa, Naoko; Iio, Atsushi; Hamamoto, Ken

    1988-01-01

    Immunoradiometric assay for CA 130 was fundamentally and clinically evaluated using a commercially available D-7111 kit. Incubation time was 4 hr with the present CA 133 kit as compared with 16 - 24 hr with conventional CA 125 kit. Laboratory performance of CA 130 kit was satisfactory for standard curve, reproducibility, and recovery test. There was well correlation between the present CA 130 kit and CA 125 kit (r = 0.931). The concentration of CA 130 in the serum was significantly higher in healthy women than men (17.3 +- 10.5 U/ml vs 9.6 +- 5.1 U/ml). Serum CA 130 levels tended to decrease with aging, regardless of sex. These levels were changeable with menstrual cycle ; i.e., these were significantly higher during menstrual phase (24.2 +- 9.0 U/ml) and significantly lower during ovulatory phase (10.9 +- 2.4 U/ml) and during menopause (12.1 +- 3.4 U/ml). Cut off serum CA 130 levels were defined as 20 U/ml for men and 38 U/ml for women. Positive rate for CA 130 was the highest in cases of ovarian cancer (80 %), followed by endometrial cancer (50 %), pancreatic cancer (47 %), benign ovarian tumor (44 %), and lung cancer (39 %). (Namekawa, K.)

  18. Tumor markers as a diagnostic key for hilar Cholangiocarcinoma

    Directory of Open Access Journals (Sweden)

    Juntermanns B

    2010-08-01

    Full Text Available Abstract Objective Hilar cholangiocarcinoma is the fourth most common gastrointestinal malignancy. CA19-9 and CEA are helpful devices in the management of gastrointestinal malignancies and belong to clinical routine in surgical oncology. But the validity of these parameters in terms of tumor extension and prognosis of bile duct malignancies still remains unclear. Methods From 1998 to 2008, we obtained preoperative CA19-9 and CEA serum levels in 136 patients with hilar cholangiocarcinoma. We correlated tumor stage, resectability rate and survival with preoperative CA 19-9 and CEA serum levels. Results CA19-9 (UICC I: 253 ± 561 U/ml; UICC II: 742 ± 1572 U/ml; UICC III: 906 ± 1708 U/ml; UICC IV: 1707 ± 3053 U/ml and CEA levels (UICC I: 2.9 ± 3.8 U/ml; UICC II: 4.6 ± 6.5 U/ml; UICC III: 18.1 ± 29.6 U/ml; UICC IV: 22.7 ± 53.9 U/ml increase significantly with rising tumor stage. Patients with pre operative serum levels of CA19-9 (> 1000 U/ml and CEA (> 14.4 ng/ml showed a significant poorer resectability rate and survival than patients with lower CA19-9 and CEA serum levels respectively. Conclusion CA19-9 and CEA serum levels are associated with the tumor stage. If preoperatively obtained CA19-9 and CEA serum levels are highly elevated patients have an even worse survival and the frequency of irresectability is significantly higher.

  19. Intrauterine Defensive Mechanism of Amniotic Fluid and Fetal Membranes

    OpenAIRE

    金山, 尚裕

    1994-01-01

    To determine the intrauterine defensive role of urinary trypsin inhibitor (UTI), we studied the effects of UTI in amniotic fluid, fetal membranes and myometrium. The level of UTI was 94±34U/ml in neonatal urine (compared to adult urine 8.0±6.0U/ml) and 88±37U/ml in amniotic fluid. This may indicate that the main source of UTI in the amniotic fluid is the fetal urine. UTI was found to be concentrated in vernix, fetal intestine, amniotic membranes and uterine myometrium. Immunostaining of term ...

  20. Isolation of lipase producing fungi from palm oil Mill effluent (POME dump sites at Nsukka

    Directory of Open Access Journals (Sweden)

    Charles Ogugua Nwuche

    2011-02-01

    Full Text Available In this study, twelve fungal lipase producing strains belonging to Aspergillus, Penicillium, Trichoderma and Mucor genera were isolated from palm oil mill effluent composts. The Aspergillus spp. were more frequent (42% and was present in all the samples assayed. Mucor sp. was the least encountered (8.3%.The lipase producing profile showed that Trichoderma (8.07-8.24 u/mL and Aspergillus (6.25 -7.54 u/mL spp. were the highest lipase producers while Mucor (5.72 u/mL was the least.

  1. Consistent model driven architecture

    Science.gov (United States)

    Niepostyn, Stanisław J.

    2015-09-01

    The goal of the MDA is to produce software systems from abstract models in a way where human interaction is restricted to a minimum. These abstract models are based on the UML language. However, the semantics of UML models is defined in a natural language. Subsequently the verification of consistency of these diagrams is needed in order to identify errors in requirements at the early stage of the development process. The verification of consistency is difficult due to a semi-formal nature of UML diagrams. We propose automatic verification of consistency of the series of UML diagrams originating from abstract models implemented with our consistency rules. This Consistent Model Driven Architecture approach enables us to generate automatically complete workflow applications from consistent and complete models developed from abstract models (e.g. Business Context Diagram). Therefore, our method can be used to check practicability (feasibility) of software architecture models.

  2. The OCoN approach to workflow modeling in object-oriented systems

    NARCIS (Netherlands)

    Wirtz, G.; Weske, M.H.; Giese, H.

    2001-01-01

    Workflow management aims at modeling and executing application processes in complex technical and organizational environments. Modern information systems are often based on object-oriented design techniques, for instance, the Unified Modeling Language (UML). These systems consist of application

  3. FTA Low-speed urban maglev research program lessons learned : March 2009.

    Science.gov (United States)

    2009-03-01

    In 1999, the Federal Transit Administration initiated the Low-Speed Urban Magnetic Levitation (UML) Program to develop magnetic levitation technology that offers a cost effective, reliable, and environmentally sound transit option for urban mass tran...

  4. Unified Medical Language System Terminology Services (UTS) API

    Data.gov (United States)

    U.S. Department of Health & Human Services — The UTS API is intended for application developers to perform Web service calls and retrieve UMLS data within their own applications. The UTS API provides the...

  5. CA 19-9 in the diagnosis and differential diagnosis of exocrine pancreatic carcinoma

    International Nuclear Information System (INIS)

    Klapdor, R.; Lehmann, U.; Bahlo, M.; Greten, H.; Ackeren, H. v.; Dallek, M.; Schreiber, W.H.

    1983-01-01

    CA 19-9 serum concentrations were determined in 56 controls and 66 patients with various pancreatic diseases using a commercially available radioimmunoassay. 56 controls showed mean serum concentrations of 7.3 +- 9.6 U/ml (anti x +- 2 SD) range 0-24, median 6), n = 21 patients suffering from chronic pancreatitis mean values of 16 +- 24 U/ml (anti x +- 2 SD) (range 4.9-42, median 13). The majority of the patients with exocrine pancreatic carcinoma demonstrated significantly elevated values: in 91% and 82% respectively, CA 19-9 levels were elevated above the upper limit of 95% of the controls (> 15 U/ml) and of the patients with chronic pancreatitis (> 37 U/ml) (P [de

  6. Methods and Technologies of XML Data Modeling for IP Mode Intelligent Measuring and Controlling System

    International Nuclear Information System (INIS)

    Liu, G X; Hong, X B; Liu, J G

    2006-01-01

    This paper presents the IP mode intelligent measuring and controlling system (IMIMCS). Based on object-oriented modeling technology of UML and XML Schema, the innovative methods and technologies of some key problems for XML data modeling in the IMIMCS were especially discussed, including refinement for systemic business by means of use-case diagram of UML, the confirmation of the content of XML data model and logic relationship of the objects of XML Schema with the aid of class diagram of UML, the mapping rules from the UML object model to XML Schema. Finally, the application of the IMIMCS based on XML for a modern greenhouse was presented. The results show that the modeling methods of the measuring and controlling data in the IMIMCS involving the multi-layer structure and many operating systems process strong reliability and flexibility, guarantee uniformity of complex XML documents and meet the requirement of data communication across platform

  7. The influence of CA 125 and CEA levels on the results of {sup 18}F-deoxyglucose positron emission tomography in suspected recurrence of epithelial ovarian cancer

    Energy Technology Data Exchange (ETDEWEB)

    Menzel, C.; Gruenwald, F. [Johann Wolfgang Goethe University, Frankfurt/Main (Germany). Department of Nuclear Medicine; Doebert, N.; Hamscho, N.; Zaplatnikov, K.; Vasvatekis, S.; Matic, V.; Woerdehoff, N.

    2004-08-01

    Background and Purpose: The follow-up of epithelial ovarian cancer (OCA) consists of clinical investigation, sonography, and tumor markers (TMs), especially CA 125. If tumor recurrence is suspected, other imaging modalities including positron emission tomography (PET) with {sup 18}F-deoxyglucose (FDG) are often used. While there is still no consensus about the method of choice and the timing of its application, this study aims to find a TM threshold at which a PET would be appropriate. Material and Methods: A total of 90 PET studies and the associated CA 125 values (normal value <35 U/ml) were available in 71 patients during the follow-up afte primary therapy for OCA. In 48 studies a CEA value (normal value <3 ng/ml) was also available. The results of PET imaging were related to the level of TM increase. Results: In 23/90 studies the PET scan was normal. These patients had a median CA 125 of 13.3 U/ml (range 4.2-168 U/ml). In 67/90 studies the PET indicated a potential recurrence of OCA and the median CA 125 was 166.7 U/ml (range 13.3-4,060 U/ml). The TM levels were significantly different (p<0.001, U-test). With one exception, there were no normal PET scans above CA 125 levels of 30 U/ml; between 20 and 30 U/ml PET was positive in 4/7 studies. Conclusion: In suspected recurrence of OCA, if imaging modalities are to be used, an FDG PET may be considered. Since the costs of this investigation are high, it should be restricted to clinical situations where it is likely to be most effective. In this study a PET indication is worthwhile at CA 125 levels of approximately 30 U/ml. (orig.)

  8. Graphical User Interface for an Observing Control System for the UK Infrared Telescope

    Science.gov (United States)

    Tan, M.; Bridger, A.; Wright, G. S.; Adamson, A. J.; Currie, M. J.; Economou, F.

    A Graphical user interface for the observing control system of UK Infrared Telescope has been developed as a part of the ORAC (Observatory Reduction and Acquisition Control) Project. We analyzed and designed the system using the Unified Modelling Language (UML) with the CASE tool Rational Rose 98. The system has been implemented in a modular way with Java packages using Swing and RMI. This system is component-based with pluggability. Object orientation concepts and UML notations have been applied throughout the development.

  9. Learning Python design patterns

    CERN Document Server

    Zlobin, Gennadiy

    2013-01-01

    This book takes a tutorial-based and user-friendly approach to covering Python design patterns. Its concise presentation means that in a short space of time, you will get a good introduction to various design patterns.If you are an intermediate level Python user, this book is for you. Prior knowledge of Python programming is essential. Some knowledge of UML is also required to understand the UML diagrams which are used to describe some design patterns.

  10. Partial purification and characterization of ligninolytic enzymes ...

    African Journals Online (AJOL)

    use

    2011-12-05

    Dec 5, 2011 ... containing 5 g wheat straw (66% w/w moisture) in a still culture SSF. Different parameters had ... (210.77 U/mL) and lignin peroxidase (54.50 U/mL) were produced when wheat straw (5 g) at 66% moisture (w/w) was used .... grinder to powder form and stored in airtight plastic jars to keep the substrate free of ...

  11. The influence of CA 125 and CEA levels on the results of 18F-deoxyglucose positron emission tomography in suspected recurrence of epithelial ovarian cancer

    International Nuclear Information System (INIS)

    Menzel, C.; Gruenwald, F.; Doebert, N.; Hamscho, N.; Zaplatnikov, K.; Vasvatekis, S.; Matic, V.; Woerdehoff, N.

    2004-01-01

    Background and Purpose: The follow-up of epithelial ovarian cancer (OCA) consists of clinical investigation, sonography, and tumor markers (TMs), especially CA 125. If tumor recurrence is suspected, other imaging modalities including positron emission tomography (PET) with 18 F-deoxyglucose (FDG) are often used. While there is still no consensus about the method of choice and the timing of its application, this study aims to find a TM threshold at which a PET would be appropriate. Material and Methods: A total of 90 PET studies and the associated CA 125 values (normal value <35 U/ml) were available in 71 patients during the follow-up afte primary therapy for OCA. In 48 studies a CEA value (normal value <3 ng/ml) was also available. The results of PET imaging were related to the level of TM increase. Results: In 23/90 studies the PET scan was normal. These patients had a median CA 125 of 13.3 U/ml (range 4.2-168 U/ml). In 67/90 studies the PET indicated a potential recurrence of OCA and the median CA 125 was 166.7 U/ml (range 13.3-4,060 U/ml). The TM levels were significantly different (p<0.001, U-test). With one exception, there were no normal PET scans above CA 125 levels of 30 U/ml; between 20 and 30 U/ml PET was positive in 4/7 studies. Conclusion: In suspected recurrence of OCA, if imaging modalities are to be used, an FDG PET may be considered. Since the costs of this investigation are high, it should be restricted to clinical situations where it is likely to be most effective. In this study a PET indication is worthwhile at CA 125 levels of approximately 30 U/ml. (orig.)

  12. Combined object-oriented approach for development of process control systems

    International Nuclear Information System (INIS)

    Antonova, I.; Batchkova, I.

    2013-01-01

    Full text: The traditional approaches for development of software control system in automation an information technology based on a directly code creation are no longer effective and successful enough. The response to these challenges is the Model Driven Engineering (MDE) or its counter part in the field of architectures Model Driven Architecture (MDA). One of the most promising approach supporting MDE and MDA is UML. It does not specify a methodology for software or system design but aims to provide an integrated modeling framework for structural, functional and behavior descriptions. The success of UML in many object-oriented approaches led to an idea of applying UML to design of multi agent systems. The approach proposed in this paper applies modified Harmony methodology and is based on the combined use of UML profile for system engineering, IEC61499 standard and FIPA standard protocols. The benefits of object-oriented paradigm and the models of IEC61499 standard are extended with UML/SysML and FIPA notations. The development phases are illustrated with the UML models of a simple process control system. The main benefits of using the proposed approach can be summarized as: it provides consistency in the syntax and underlying semantics; increases the potential and likelihood of reuse; supports the whole software development life cycle in the field of process control. Including the SysML features, based on extended activity and parametric diagrams, flow ports and items to the proposed approach opens the possibilities for modeling of continuous system and support the development in field of process control. Another advantage, connected to the UML/MARTE profile is the possibility for analysis of the designed system and detailed design of the hardware and software platform of the modeled application. Key words: object-oriented modeling, control system, UML, SysML, IEC 61499

  13. Enumeration of minimal stoichiometric precursor sets in metabolic networks.

    Science.gov (United States)

    Andrade, Ricardo; Wannagat, Martin; Klein, Cecilia C; Acuña, Vicente; Marchetti-Spaccamela, Alberto; Milreu, Paulo V; Stougie, Leen; Sagot, Marie-France

    2016-01-01

    What an organism needs at least from its environment to produce a set of metabolites, e.g. target(s) of interest and/or biomass, has been called a minimal precursor set. Early approaches to enumerate all minimal precursor sets took into account only the topology of the metabolic network (topological precursor sets). Due to cycles and the stoichiometric values of the reactions, it is often not possible to produce the target(s) from a topological precursor set in the sense that there is no feasible flux. Although considering the stoichiometry makes the problem harder, it enables to obtain biologically reasonable precursor sets that we call stoichiometric. Recently a method to enumerate all minimal stoichiometric precursor sets was proposed in the literature. The relationship between topological and stoichiometric precursor sets had however not yet been studied. Such relationship between topological and stoichiometric precursor sets is highlighted. We also present two algorithms that enumerate all minimal stoichiometric precursor sets. The first one is of theoretical interest only and is based on the above mentioned relationship. The second approach solves a series of mixed integer linear programming problems. We compared the computed minimal precursor sets to experimentally obtained growth media of several Escherichia coli strains using genome-scale metabolic networks. The results show that the second approach efficiently enumerates minimal precursor sets taking stoichiometry into account, and allows for broad in silico studies of strains or species interactions that may help to understand e.g. pathotype and niche-specific metabolic capabilities. sasita is written in Java, uses cplex as LP solver and can be downloaded together with all networks and input files used in this paper at http://www.sasita.gforge.inria.fr.

  14. Bacillus sp. Acting as Dual Role for Corrosion Induction and Corrosion Inhibition with Carbon Steel (CS

    Directory of Open Access Journals (Sweden)

    Santosh K. Karn

    2017-10-01

    Full Text Available Present work investigated the role of five different bacteria species as a corrosion inducer as well as corrosion inhibitor with carbon steel (CS. We observed the ability of different bacteria species on the metal surface attachment, biofilm formation, and determined Peroxidase, Catalase enzyme activity in the detached biofilm from the CS surface. We found that each strain has diverse conduct for surface attachment like DS1 3.3, DS2 2.5, DS3 4.3, DS4 4.0, and DS5 4.71 log cfu/cm2 and for biofilm 8.3 log cfu/cm2. The enzyme Peroxidase, Catalase was found in huge concentration inside the biofilm Peroxidase was maximum for DS4 36.0 U/ml and least for DS3 19.54 U/ml. Whereas, Catalase was highest for DS4, DS5 70.14 U/ml and least 57.2 U/ml for DS2. Scanning electron microscopy (SEM was conducted to examine the biofilm and electrochemical impedance spectroscopy (EIS were utilized to observe corrosion in the presence of bacteria. The electrochemical results confirmed that DS1, DS3, DS4, and DS5 strains have statistically significant MIC-factors (Microbially Influenced Corrosion of 5.46, 8.51, 2.36, and 1.04, while DS2 protective effect factor of 0.89. Weight reduction results with carbon steel likewise supports that corrosion was initiated by DS1 and DS3, while DS2 and DS5 have no any impact though with DS4 we watched less weight reduction however assumed no role in the corrosion. We established the relation of Peroxidase enzyme activity of the isolates. DS1, DS3 and having Peroxidase in the range 22.18, 19.54 U/ml which induce the corrosion whereas DS2 and DS5 having 28.57 and 27.0 U/ml has no any effect and DS4 36 U/ml has inhibitory effect, increasing concentration inhibiting the corrosion. For Catalase DS1, DS3 have 67.28, 61.57 U/ml which induce corrosion while DS2 and DS5 57.71 and 59.14 U/ml also has no effect whereas DS4 70.14 U/ml can inhibit corrosion. Results clearly express that in a specific range both enzymes can induce the corrosion

  15. Proteases from Latex of Euphorbia spp. and Its Application on Milk Clot Formation

    Directory of Open Access Journals (Sweden)

    Fidia Fibriana

    2015-09-01

    Full Text Available Crude proteases were extracted from Euphorbiaceae family, i.e. E. milii var imperata, E. trigona, and E. maculata. Among those three crude proteases, the activity of protease from E. trigona was the highest (812.50 U/ml, whereas E. milii and E. maculata crude proteases activity were 298.60 U/ml and 95.80 U/ml, respectively. E. maculata protein concentration was the highest among those three crude enzymes (1.206 mg/ml. The optimum pH and temperature of the enzymes were pH 7.0, pH 6.0, pH 6.5 and 60 °C, 50 °C, and 50 °C, respectively. Crude protease from E. milii var imperata, E. trigona, and E. maculata retained proteolytic activity over a wide range of pH (5.0–9.0 and temperature (up to 65 °C with casein as substrate. All crude proteases showed milk clotting activity ranged from 0.58 U/ml to 1.01 U/ml. Thus, these crude proteases are potential to be applied in dairy industries. However, further study on enzyme purification and characterization are necessary to obtain high purity of proteases before its application.Protease kasar berhasil diekstrak dari tanaman family Euphorbiaceae, yaitu E. milii var imperata, E. trigona, dan E. maculata. Diantara ketiga protease tersebut, aktivitas protease tertinggi diperoleh dari E. trigona (812,50 U/ml, sedangkan aktivitas protease dari E. milii dan E. maculata adalah 298,60 U/ml dan 95,80 U/ml, berturut-turut. Konsentrasi total protein tertinggi terdapat pada protease kasar E. maculata (1,206 mg/ml. pH dan suhu optimum ketiga enzim tersebut adalah pH 7.0, pH 6.0, pH 6.5 dan suhu 60 °C, 50 °C, and 50 °C, berturut-turut. Protease kasar dari E. milii var imperata, E. trigona, dan E. maculata menunjukkan aktivitas proteolitik pada rentang pH 5.0–9.0 dan rentang suhu sampai 65 °C menggunakan kasein sebagai substrat. Semua protease kasar menunjukkan aktivitas penggumpalan susu dengan rentang dari 0,58 U/ml sampai 1,01 U/ml. Berdasarkan hasil yang diperoleh, protease kasar dari ketiga jenis tanaman ini

  16. The MGED Ontology: a resource for semantics-based description of microarray experiments.

    Science.gov (United States)

    Whetzel, Patricia L; Parkinson, Helen; Causton, Helen C; Fan, Liju; Fostel, Jennifer; Fragoso, Gilberto; Game, Laurence; Heiskanen, Mervi; Morrison, Norman; Rocca-Serra, Philippe; Sansone, Susanna-Assunta; Taylor, Chris; White, Joseph; Stoeckert, Christian J

    2006-04-01

    The generation of large amounts of microarray data and the need to share these data bring challenges for both data management and annotation and highlights the need for standards. MIAME specifies the minimum information needed to describe a microarray experiment and the Microarray Gene Expression Object Model (MAGE-OM) and resulting MAGE-ML provide a mechanism to standardize data representation for data exchange, however a common terminology for data annotation is needed to support these standards. Here we describe the MGED Ontology (MO) developed by the Ontology Working Group of the Microarray Gene Expression Data (MGED) Society. The MO provides terms for annotating all aspects of a microarray experiment from the design of the experiment and array layout, through to the preparation of the biological sample and the protocols used to hybridize the RNA and analyze the data. The MO was developed to provide terms for annotating experiments in line with the MIAME guidelines, i.e. to provide the semantics to describe a microarray experiment according to the concepts specified in MIAME. The MO does not attempt to incorporate terms from existing ontologies, e.g. those that deal with anatomical parts or developmental stages terms, but provides a framework to reference terms in other ontologies and therefore facilitates the use of ontologies in microarray data annotation. The MGED Ontology version.1.2.0 is available as a file in both DAML and OWL formats at http://mged.sourceforge.net/ontologies/index.php. Release notes and annotation examples are provided. The MO is also provided via the NCICB's Enterprise Vocabulary System (http://nciterms.nci.nih.gov/NCIBrowser/Dictionary.do). Stoeckrt@pcbi.upenn.edu Supplementary data are available at Bioinformatics online.

  17. Diagnostic accuracy of serum iga anti-tissue transglutaminase antibody in the diagnosis of celiac disease

    International Nuclear Information System (INIS)

    Lodhi, M. A.; Ayub, A.; Saleem, M. Z.; Munir, T.

    2017-01-01

    Objective: To determine the diagnostic accuracy of serum IgA anti-tissue transglutaminase antibody in the diagnosis of celiac disease taking histopathology as gold standard. Study Design: Cross-sectional survey. Place and Duration of Study: This study was conducted at the department of Pediatrics, Military Hospital Rawalpindi from April 2015 to July 2016. Patients and Methods: Ninety-five consecutive children presenting with suspicion of celiac disease were included in this study after taking written informed consent. A predesigned proforma was used to record patient’s demographic details. Anti-tTG level of >=25 U/ml was taken as diagnostic of celiac disease while results of histopathology on endoscopic biopsy were taken as gold standard. Results: The mean age of the patients was 6.48 ± 3.20 years and majority (n=53, 55.8 percent) of the children were aged between 5 to 10 years. The serum anti-tTG level ranged from 8.0 U/ml to 759.0 U/ml with a mean of 298.75 ± 225.51 U/ml. Taking a cut-off value of >=25 U/ml for anti-tTG, 81 (85.3 percent) children were suspected of celiac disease. Histopathology of endoscopic biopsy confirmed celiac disease in 68 (71.6 percent) children with 62 true positive, 19 false positive, 6 false negative and 8 true negative cases. It yielded 91.18 percent sensitivity, 29.63 percent specificity and 73.68 percent accuracy for anti-tTG (>=25 U/ml) in the diagnosis of celiac disease with positive and negative predictive values of 76.54 percent and 57.14 percent respectively. Conclusion: IgA anti-tissue transglutaminase antibody (>=25 U/ml) was found to be highly sensitive test for the detection of celiac disease in children. (author)

  18. Novel marine actinobacteria from emerald Andaman & Nicobar Islands: a prospective source for industrial and pharmaceutical byproducts.

    Science.gov (United States)

    Meena, Balakrishnan; Rajan, Lawrance Anbu; Vinithkumar, Nambali Valsalan; Kirubagaran, Ramalingam

    2013-06-22

    Andaman and Nicobar Islands situated in the eastern part of Bay of Bengal are one of the distinguished biodiversity hotspot. Even though number of studies carried out on the marine flora and fauna, the studies on actinobacteria from Andaman and Nicobar Islands are meager. The aim of the present study was to screen the actinobacteria for their characterization and identify the potential sources for industrial and pharmaceutical byproducts. A total of 26 actinobacterial strains were isolated from the marine sediments collected from various sites of Port Blair Bay where no collection has been characterized previously. Isolates were categorized under the genera: Saccharopolyspora, Streptomyces, Nocardiopsis, Streptoverticillium, Microtetraspora, Actinopolyspora, Actinokineospora and Dactylosporangium. Majority of the isolates were found to produce industrially important enzymes such as amylase, protease, gelatinase, lipase, DNase, cellulase, urease and phosphatase, and also exhibited substantial antibacterial activity against human pathogens. 77% of isolates exhibited significant hemolytic activity. Among 26 isolates, three strains (NIOT-VKKMA02, NIOT-VKKMA22 and NIOT-VKKMA26) were found to generate appreciable extent of surfactant, amylase, cellulase and protease enzyme. NIOT-VKKMA02 produced surfactant using kerosene as carbon source and emulsified upto E(24)-63.6%. Moreover, NIOT-VKKMA02, NIOT-VKKMA22 and NIOT-VKKMA26 synthesized 13.27 U/ml, 9.85 U/ml and 8.03 U/ml amylase; 7.75 U/ml, 5.01 U/ml and 2.08 U/ml of cellulase and 11.34 U/ml, 6.89 U/ml and 3.51 U/ml of protease enzyme, respectively. High diversity of marine actinobacteria was isolated and characterized in this work including undescribed species and species not previously reported from emerald Andaman and Nicobar Islands, including Streptomyces griseus, Streptomyces venezuelae and Saccharopolyspora salina. The enhanced salt, pH and temperature tolerance of the actinobacterial isolates along with their

  19. Croatian Cadastre Database Modelling

    Directory of Open Access Journals (Sweden)

    Zvonko Biljecki

    2013-04-01

    Full Text Available The Cadastral Data Model has been developed as a part of a larger programme to improve products and production environment of the Croatian Cadastral Service of the State Geodetic Administration (SGA. The goal of the project was to create a cadastral data model conforming to relevant standards and specifications in the field of geoinformation (GI adapted by international organisations for standardisation under the competence of GI (ISO TC211 and OpenGIS and it implementations.The main guidelines during the project have been object-oriented conceptual modelling of the updated users' requests and a "new" cadastral data model designed by SGA - Faculty of Geodesy - Geofoto LLC project team. The UML of the conceptual model is given per all feature categories and is described only at class level. The next step was the UML technical model, which was developed from the UML conceptual model. The technical model integrates different UML schemas in one united schema.XML (eXtensible Markup Language was applied for XML description of UML models, and then the XML schema was transferred into GML (Geography Markup Language application schema. With this procedure we have completely described the behaviour of each cadastral feature and rules for the transfer and storage of cadastral features into the database.

  20. Evaluation of secretome of highly efficient lignocellulolytic Penicillium sp. Dal 5 isolated from rhizosphere of conifers.

    Science.gov (United States)

    Rai, Rohit; Kaur, Baljit; Singh, Surender; Di Falco, Macros; Tsang, Adrian; Chadha, B S

    2016-09-01

    Penicillium sp. (Dal 5) isolated from rhizosphere of conifers from Dalhousie (Himachal Pradesh, India) was found to be an efficient cellulolytic strain. The culture under shake flask on CWR (cellulose, wheat bran and rice straw) medium produced appreciably higher levels of endoglucanase (35.69U/ml), β-glucosidase (4.20U/ml), cellobiohydrolase (2.86U/ml), FPase (1.2U/ml) and xylanase (115U/ml) compared to other Penicillium strains reported in literature. The mass spectroscopy analysis of Penicillium sp. Dal 5 secretome identified 108 proteins constituting an array of CAZymes including glycosyl hydrolases (GH) belonging to 24 different families, polysaccharide lyases (PL), carbohydrate esterases (CE), lytic polysaccharide mono-oxygenases (LPMO) in addition to swollenin and a variety of carbohydrate binding modules (CBM) indicating an elaborate genetic potential of this strain for hydrolysis of lignocellulosics. Further, the culture extract was evaluated for hydrolysis of alkali treated rice straw, wheat straw, bagasse and corn cob at 10% substrate loading rate. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. Scale-up of an alkaline protease from Bacillus pumilus MTCC 7514 utilizing fish meal as a sole source of nutrients.

    Science.gov (United States)

    Gupta, Rishikesh Kumar; Prasad, Dinesh; Sathesh, Jaykumar; Naidu, Ramachandra Boopathy; Kamini, Numbi Ramudu; Palanivel, Saravanan; Gowthaman, Marichetti Kuppuswami

    2012-09-01

    Fish meal grades SL1 and SL2 from Sardine (Sardinella longiceps) and NJ from Pink Perch (Nemipterus japonicas) were evaluated as a sole source of carbon and nitrogen in the medium for alkaline protease production by Bacillus pumilus MTCC 7514. The analysis of the fish meal suggests that the carbon and nitrogen contents in fish meal are sufficient to justify its choice as replacement for other nutrients. Protease production increased significantly (4,914 U/ml) in medium containing only fish meal, compared with the basal medium (2,646 U/ml). However, the elimination of inorganic salts from media reduced the protease productivity. In addition, all the three grades of fish meal yielded almost the same amounts of protease when employed as the sole source of carbon and nitrogen. Nevertheless, the best results were observed in fish meal SL1 medium. Furthermore, protease production was enhanced to 6,966 U/ml and 7,047 U/ml on scaling up from flask (4,914 U/ml) to 3.7 and 20 L fermenters, respectively, using fish meal (10 g/l). Similarly, the corresponding improvement in productivities over flask (102.38 U/ml/h) was 193.5 and 195.75 U/ml/h in 3.7 and 20 L fermenters, respectively. The crude protease was found to have dehairing ability in leather processing, which is bound to have great environmental benefits.

  2. Early determination of the congenital hypothyroidism by means of the cuantification of STH and T4 by radioimmunoassay method

    International Nuclear Information System (INIS)

    De Penados, R.C.

    1986-11-01

    It was investigated the advantages and disadvantages and conditions of working for the diagnosis of the congenital hypothyroidism by RIA, and its future implementation. It was determined concentration of neonatal STH and neonatal T4 in whole blood of 517 new borns, obtained by capilar punction and recollected in filter paper. 261 samples were found with levels of T4 between normal limits and STH between 0 and 12.5 u U/ml correspond to a normal thyroid function. 29 samples with normal T4 and STH above 30 u U/ml, correspond to a possible primary hypothyroidism. 171 samples with normal T4 and STH between 12.5 and 30 u U/ml were found. (Author)

  3. Production of Cellulolytic and Hemicellulolytic Enzymes From Aureobasidium pulluans on Solid State Fermentation

    Science.gov (United States)

    Leite, Rodrigo Simões Ribeiro; Bocchini, Daniela Alonso; da Silva Martins, Eduardo; Silva, Dênis; Gomes, Eleni; da Silva, Roberto

    This article investigates a strain of the yeast Aureobasidium pullulans for cellulase and hemicellulase production in solid state fermentation. Among the substrates analyzed, the wheat bran culture presented the highest enzymatic production (1.05 U/mL endoglucanase, 1.3 U/mL β-glucosidase, and 5.0 U/mL xylanase). Avicelase activity was not detected. The optimum pH and temperature for xylanase, endoglucanase and β-glucosidase were 5.0 and 50, 4.5 and 60, 4.0 and 75°C, respectively. These enzymes remained stable between a wide range of pH. The β-glucosidase was the most thermostable enzyme remaining 100% active when incubated at 75°C for 1 h.

  4. Feasibility and Utility of Lexical Analysis for Occupational Health Text.

    Science.gov (United States)

    Harber, Philip; Leroy, Gondy

    2017-06-01

    Assess feasibility and potential utility of natural language processing (NLP) for storing and analyzing occupational health data. Basic NLP lexical analysis methods were applied to 89,000 Mine Safety and Health Administration (MSHA) free text records. Steps included tokenization, term and co-occurrence counts, term annotation, and identifying exposure-health effect relationships. Presence of terms in the Unified Medical Language System (UMLS) was assessed. The methods efficiently demonstrated common exposures, health effects, and exposure-injury relationships. Many workplace terms are not present in UMLS or map inaccurately. Use of free text rather than narrowly defined numerically coded fields is feasible, flexible, and efficient. It has potential to encourage workers and clinicians to provide more data and to support automated knowledge creation. The lexical method used is easily generalizable to other areas. The UMLS vocabularies should be enhanced to be relevant to occupational health.

  5. Connecting Architecture and Implementation

    Science.gov (United States)

    Buchgeher, Georg; Weinreich, Rainer

    Software architectures are still typically defined and described independently from implementation. To avoid architectural erosion and drift, architectural representation needs to be continuously updated and synchronized with system implementation. Existing approaches for architecture representation like informal architecture documentation, UML diagrams, and Architecture Description Languages (ADLs) provide only limited support for connecting architecture descriptions and implementations. Architecture management tools like Lattix, SonarJ, and Sotoarc and UML-tools tackle this problem by extracting architecture information directly from code. This approach works for low-level architectural abstractions like classes and interfaces in object-oriented systems but fails to support architectural abstractions not found in programming languages. In this paper we present an approach for linking and continuously synchronizing a formalized architecture representation to an implementation. The approach is a synthesis of functionality provided by code-centric architecture management and UML tools and higher-level architecture analysis approaches like ADLs.

  6. Toward a Grid Work flow Formal Composition

    International Nuclear Information System (INIS)

    Hlaoui, Y. B.; BenAyed, L. J.

    2007-01-01

    This paper exposes a new approach for the composition of grid work flow models. This approach proposes an abstract syntax for the UML Activity Diagrams (UML-AD) and a formal foundation for grid work flow composition in form of a work flow algebra based on UML-AD. This composition fulfils the need for collaborative model development particularly the specification and the reduction of the complexity of grid work flow model verification. This complexity has arisen with the increase in scale of grid work flow applications such as science and e-business applications since large amounts of computational resources are required and multiple parties could be involved in the development process and in the use of grid work flows. Furthermore, the proposed algebra allows the definition of work flow views which are useful to limit the access to predefined users in order to ensure the security of grid work flow applications. (Author)

  7. DETERMINATION OF ENZYMES PRODUCED BY CERIPORIOPSIS SUBVERMISPORA DURING PRETREATMENT OF DIFFERENT BIOMASS SOURCES

    Directory of Open Access Journals (Sweden)

    Miroslav Ondrejovič

    2012-02-01

    Full Text Available The aim of this paper was to study of lignocellulolytic enzymes producing by Ceriporiopsis subvermispora during its cultivation on three types of plant biomass differentiated by chemical composition and physical properties (wheat straw, pine and poplar wood. The activity of lignocellulolytic enzymes in cultivation medium was determined by catalytic transformation of their natural substrates to products which were detected by photometric methods. Cellulase activities were very low while xylanases predominated. Wheat straw was best substrate for production of cellulases (4.38 U/mL and xylanases (23.34 U/mL. The maximum activity of cellulase and xylanase was reached at 8th and 3rd day, respectively. Laccase activity reached the maximum after 16 days and then gradually decreased. The best substrate for production of laccases was poplar wood (1.67 U/mL.

  8. Production and characterization of xylanase from Thielaviopsis basicola

    Energy Technology Data Exchange (ETDEWEB)

    Ghosh, V K; Deb, J K

    1988-08-01

    The black rot fungus Thielaviopsis basicola has the ability to grow on cellulosic biomass, producing xylanase. Of the four cellulosic substrates tested, rice straw was found to be the best for production of xylanase. A xylanase activity of 34 U/ml was obtained with rice straw which was more than three times that obtained with larchwood xylan. The ..beta..-xylosidase activities obtained with these two substrates were 0.05 U/ml and 0.016 U/ml respectively. Both enzymes are active at pH 5 but the temperature optima of xylanase and ..beta..-xylosidase activities are 60/sup 0/C and 40/sup 0/C respectively. The xylanase activity is stable over a pH range of 4-8 but the stability towards temperature falls sharply above 50/sup 0/C.

  9. Thermomyces lanuginosus CBS 395.62/b Strain as Rich Source of α-Galactosidase Enzyme

    Directory of Open Access Journals (Sweden)

    Quang D. Nguyen

    2003-01-01

    Full Text Available Seventeen Thermomyces lanuginosus strains, cultivated on raffinose and sucrose, were ranked on the basis of α-galactosidase activities. T. lanuginosus CBS 395.62/b strain showed the highest α-galactosidase activity on both investigated carbohydrates. Several carbon sources were tested as potential inducers for the α-galactosidase synthesis. On melibiose substrate α-galactosidase activity was higher in the intracellular fraction than in the filtrate of the fermentation broth, although both values were very low and did not reach the value of 1 U/mL. Raffinose, sucrose and Lactosucrose® proved to be inducers for α-galactosidase production. The highest titer (about 30 U/mL was achieved on 1 % sucrose and 0.45 % ammonium acetate. The optimum sucrose and ammonium acetate concentrations, at which about 90 U/mL α-galactosidase activity was reached during an 8-day fermentation, were 3 and 0.9 %, respectively.

  10. Activity-based DEVS modeling

    DEFF Research Database (Denmark)

    Alshareef, Abdurrahman; Sarjoughian, Hessam S.; Zarrin, Bahram

    2018-01-01

    architecture and the UML concepts. In this paper, we further this work by grounding Activity-based DEVS modeling and developing a fully-fledged modeling engine to demonstrate applicability. We also detail the relevant aspects of the created metamodel in terms of modeling and simulation. A significant number......Use of model-driven approaches has been increasing to significantly benefit the process of building complex systems. Recently, an approach for specifying model behavior using UML activities has been devised to support the creation of DEVS models in a disciplined manner based on the model driven...... of the artifacts of the UML 2.5 activities and actions, from the vantage point of DEVS behavioral modeling, is covered in details. Their semantics are discussed to the extent of time-accurate requirements for simulation. We characterize them in correspondence with the specification of the atomic model behavior. We...

  11. Extraction of UMLS® Concepts Using Apache cTAKES™ for German Language.

    Science.gov (United States)

    Becker, Matthias; Böckmann, Britta

    2016-01-01

    Automatic information extraction of medical concepts and classification with semantic standards from medical reports is useful for standardization and for clinical research. This paper presents an approach for an UMLS concept extraction with a customized natural language processing pipeline for German clinical notes using Apache cTAKES. The objectives are, to test the natural language processing tool for German language if it is suitable to identify UMLS concepts and map these with SNOMED-CT. The German UMLS database and German OpenNLP models extended the natural language processing pipeline, so the pipeline can normalize to domain ontologies such as SNOMED-CT using the German concepts. For testing, the ShARe/CLEF eHealth 2013 training dataset translated into German was used. The implemented algorithms are tested with a set of 199 German reports, obtaining a result of average 0.36 F1 measure without German stemming, pre- and post-processing of the reports.

  12. Modeling and Testing Legacy Data Consistency Requirements

    DEFF Research Database (Denmark)

    Nytun, J. P.; Jensen, Christian Søndergaard

    2003-01-01

    An increasing number of data sources are available on the Internet, many of which offer semantically overlapping data, but based on different schemas, or models. While it is often of interest to integrate such data sources, the lack of consistency among them makes this integration difficult....... This paper addresses the need for new techniques that enable the modeling and consistency checking for legacy data sources. Specifically, the paper contributes to the development of a framework that enables consistency testing of data coming from different types of data sources. The vehicle is UML and its...... accompanying XMI. The paper presents techniques for modeling consistency requirements using OCL and other UML modeling elements: it studies how models that describe the required consistencies among instances of legacy models can be designed in standard UML tools that support XMI. The paper also considers...

  13. Influence of organic nitrogen amendment, containing amino acids on the cellulase and xylanase, produced by Trichoderma spp. isolates

    Directory of Open Access Journals (Sweden)

    D. Draganova

    2017-09-01

    Full Text Available Abstract. Cellulases and hemicellulases are amount the main hydrolytic enzymes, involved in the bioconversion of lignocellulose material by microorganisms. Filamentous fungi of the genus Trichoderma are one of the most studied and good producer of cellulases and hemicellulases. The nutrients balance, especially carbon to nitrogen ratio, is one of the main factors of the biodegradation. The ability of 37 local isolates of Trichoderma sp. to produce cellulases and xylanase were tested in solid state cultivation on wheat straw as a substrate whit two variants: 1. the straw was only moistured with destilated water (CN 80:1; 2. the C:N ratio of the straw was adjusted to 30:1 using organic nitrogen amendment. There is a significant difference in the enzymatic activity of the isolates in their cultivation on straw with CN 80 and CN 30. The highest carboxymethylcellulase (CMCase activity at CN 80 showed T1T (110.19U/ml, and in the variant at CN 30 - TD (369.07U/ml. The highest β-glucosidase activity on both variants CN 80 and CN 30 was established for TG (2743.1U/ml - 12679.9U/ml. The highest xylanase activity at CN 80 and CN 30 was measured on T4I (21311.5U/ml – 47937.5U/ml. After ONA addition, all enzymes activities have increased several times, indicating the enhancing effect of the additive. The average activity of CMCase increased 6.1 times, the average β - glucosidase activity increased 5.1 times, while the xylanase activity increased 4.9 times for all tested isolates. The increase in activity of the investigated enzymes showed different patterns.

  14. Prediction of acute renal allograft rejection in early post-transplantation period by soluble CD30.

    Science.gov (United States)

    Dong, Wang; Shunliang, Yang; Weizhen, Wu; Qinghua, Wang; Zhangxin, Zeng; Jianming, Tan; He, Wang

    2006-06-01

    To evaluate the feasibility of serum sCD30 for prediction of acute graft rejection, we analyzed clinical data of 231 patients, whose serum levels of sCD30 were detected by ELISA before and after transplantation. They were divided into three groups: acute rejection group (AR, n = 49), uncomplicated course group (UC, n = 171) and delayed graft function group (DGF, n = 11). Preoperative sCD30 levels of three groups were 183 +/- 74, 177 +/- 82 and 168 +/- 53 U/ml, respectively (P = 0.82). Significant decrease of sCD30 was detected in three groups on day 5 and 10 post-transplantation respectively (52 +/- 30 and 9 +/- 5 U/ml respectively, P sCD30 values on day 5 post-transplantation (92 +/- 27 U/ml vs. 41 +/- 20 U/ml and 48 +/- 18 U/ml, P sCD30 levels on day 10 post-transplantation were virtually similar in patients of three groups (P = 0.43). Receiver operating characteristic (ROC) curve demonstrated that sCD30 level on day 5 post-transplantation could differentiate patients who subsequently suffered acute allograft rejection from others (area under ROC curve 0.95). According to ROC curve, 65 U/ml may be the optimal operational cut-off level to predict impending graft rejection (specificity 91.8%, sensitivity 87.1%). Measurement of soluble CD30 on day 5 post-transplantation might offer a noninvasive means to recognize patients at risk of impending acute graft rejection during early post-transplantation period.

  15. Bone scan and serum CA 15-3 in bone metastasis in breast cancer

    International Nuclear Information System (INIS)

    Mendoza, G.; Cano, R.; Morales, R.; Guzman, C.

    1996-01-01

    CA 15-3 is a tumor marker useful in evolution control of breast cancer, being the serum levels trend the most important parameter. The purpose of this study was to report our experience and show the concordance of bone scan and CA 15-3 in patients with breast cancer attending the Breast and Bone Department of INEN from June to December 1993. One hundred patients had serum CA 15-3 quantification between June and December of 1993 in Nuclear Medicine Center (Peruvian Institute of Nuclear Energy and National Institute of Neoplasic Diseases). We selected 52 patients which simultaneously had a bone scan performed. Patients age ranged from 21 to 67 years (media of 44,57 years). 99m Tc methylenediphosphonate produced by IPEN was the radiopharmaceutical employed. A GE AZS-400 gamma camera was utilized to obtain the bone scans. Ca 15-5 quantification was performed with ELSA-CA 15-3 (CIS bio France) IRMA kit. Bone scan and CA 15-3 media of 17,06 U/ml (DS 15,4). Eight patients had a positive bone scan with a CA 15-3 media of 41,6 U/ml (SD 23,0). CA 15-3 levels ranged between 4,6 and 96,0 U/ml in the first group and 10,1 U/ml to 75,0 U/ml in the second group. Using a cut-off point of 30 U/ml the sensitivity of CA 15-3 was 62,5% and the specificity 93,2% respectively. Mean CA 15-3 values of the negative and positive bone scan groups were significantly different (p=0,0361). The high negative predictive value of CA 15-3 may help to establish which patients will benefit from bone scan procedure. (authors) 42 refs., 2 tabs

  16. Enabling online studies of conceptual relationships between medical terms: developing an efficient web platform.

    Science.gov (United States)

    Albin, Aaron; Ji, Xiaonan; Borlawsky, Tara B; Ye, Zhan; Lin, Simon; Payne, Philip Ro; Huang, Kun; Xiang, Yang

    2014-10-07

    The Unified Medical Language System (UMLS) contains many important ontologies in which terms are connected by semantic relations. For many studies on the relationships between biomedical concepts, the use of transitively associated information from ontologies and the UMLS has been shown to be effective. Although there are a few tools and methods available for extracting transitive relationships from the UMLS, they usually have major restrictions on the length of transitive relations or on the number of data sources. Our goal was to design an efficient online platform that enables efficient studies on the conceptual relationships between any medical terms. To overcome the restrictions of available methods and to facilitate studies on the conceptual relationships between medical terms, we developed a Web platform, onGrid, that supports efficient transitive queries and conceptual relationship studies using the UMLS. This framework uses the latest technique in converting natural language queries into UMLS concepts, performs efficient transitive queries, and visualizes the result paths. It also dynamically builds a relationship matrix for two sets of input biomedical terms. We are thus able to perform effective studies on conceptual relationships between medical terms based on their relationship matrix. The advantage of onGrid is that it can be applied to study any two sets of biomedical concept relations and the relations within one set of biomedical concepts. We use onGrid to study the disease-disease relationships in the Online Mendelian Inheritance in Man (OMIM). By crossvalidating our results with an external database, the Comparative Toxicogenomics Database (CTD), we demonstrated that onGrid is effective for the study of conceptual relationships between medical terms. onGrid is an efficient tool for querying the UMLS for transitive relations, studying the relationship between medical terms, and generating hypotheses.

  17. Strain improvement and optimization for β-glucosidase production in Aspergillus niger by low-energy N+ implantation

    International Nuclear Information System (INIS)

    Diao Jinshan; Wang Li; Chen Zhen; Liu Hui; Nie Guangjun; Zheng Zhiming

    2010-01-01

    Low-energy N + implantation was employed to mutate Aspergillus niger Au to enhance productivity of β-glucosidase. Effects of N + on strains, survival and mutation rate were studied. After several rounds of implantation, activity of β-glucosidase of the final mutant Au 0847 reached 13.75 U/mL, which is higher by 106.8% than that of original strain Au, and its heritability was stabilized. Activity of β-glucosidase of Au 0847 reached 30.53 U/mL after further fermentation condition optimization. (authors)

  18. Study of a High-Yield Cellulase System Created by Heavy-Ion Irradiation-Induced Mutagenesis of Aspergillus niger and Mixed Fermentation with Trichoderma reesei

    Science.gov (United States)

    Chen, Ji-Hong; Li, Wen-Jian; Liu, Jing; Hu, Wei; Xiao, Guo-Qing; Dong, Miao-Yin; Wang, Yu-Chen

    2015-01-01

    The aim of this study was to evaluate and validate the efficiency of 12C6+ irradiation of Aspergillus niger (A. niger) or mutagenesis via mixed Trichoderma viride (T. viride) culturing as well as a liquid cultivation method for cellulase production via mixed Trichoderma reesei (T. reesei) and A. niger culture fermentation. The first mutagenesis approach was employed to optimize yield from a cellulase-producing strain via heavy-ion mutagenesis and high-throughput screening, and the second was to effectively achieve enzymatic hydrolysis of cellulase from a mixed culture of mutant T. viride and A. niger. We found that 12C6+-ion irradiation induced changes in cellulase biosynthesis in A. niger but had no effect on the time course of the synthesis. It is notable that the exoglucanases (CBH) activities of A. niger strains H11-1 and H differed (6.71 U/mL vs. 6.01 U/mL) and were significantly higher than that of A. niger mutant H3-1. Compared with strain H, the filter paper assay (FPA), endoglucanase (EG) and β-glucosidase (BGL) activities of mutant strain H11-1 were increased by 250.26%, 30.26% and 34.91%, respectively. A mixed culture system was successfully optimized, and the best ratio of T. reesei to A. niger was 5:1 for 96 h with simultaneous inoculation. The BGL activity of the mixed culture increased after 72 h. At 96 h, the FPA and BGL activities of the mixed culture were 689.00 and 797.15 U/mL, respectively, significantly higher than those of monocultures, which were 408.70 and 646.98 U/mL for T. reesei and 447.29 and 658.89 U/mL for A. niger, respectively. The EG activity of the mixed culture was 2342.81 U/mL, a value that was significantly higher than that of monocultures at 2206.57 U/mL for T. reesei and 1727.62 U/mL for A. niger. In summary, cellulose production and hydrolysis yields were significantly enhanced by the proposed combination scheme. PMID:26656155

  19. Epstein-Barr virus is related with 5-aminosalicylic acid, tonsillectomy, and CD19(+) cells in Crohn's disease.

    Science.gov (United States)

    Andreu-Ballester, Juan C; Gil-Borrás, Rafael; García-Ballesteros, Carlos; Catalán-Serra, Ignacio; Amigo, Victoria; Fernández-Fígares, Virgina; Cuéllar, Carmen

    2015-04-21

    To study anti-Epstein-Barr virus (EBV) IgG antibodies in Crohn's disease in relation to treatment, immune cells, and prior tonsillectomy/appendectomy. This study included 36 CD patients and 36 healthy individuals (controls), and evaluated different clinical scenarios (new patient, remission and active disease), previous mucosa-associated lymphoid tissue removal (tonsillectomy and appendectomy) and therapeutic regimens (5-aminosalicylic acid, azathioprine, anti-tumor necrosis factor, antibiotics, and corticosteroids). T and B cells subsets in peripheral blood were analyzed by flow cytometry (markers included: CD45, CD4, CD8, CD3, CD19, CD56, CD2, CD3, TCRαβ and TCRγδ) to relate with the levels of anti-EBV IgG antibodies, determined by enzyme-linked immunosorbent assay. The lowest anti-EBV IgG levels were observed in the group of patients that were not in a specific treatment (95.4 ± 53.9 U/mL vs 131.5 ± 46.2 U/mL, P = 0.038). The patients that were treated with 5-aminosalicylic acid showed the highest anti-EBV IgG values (144.3 U/mL vs 102.6 U/mL, P = 0.045). CD19(+) cells had the largest decrease in the group of CD patients that received treatment (138.6 vs 223.9, P = 0.022). The analysis of anti-EBV IgG with respect to the presence or absence of tonsillectomy showed the highest values in the tonsillectomy group of CD patients (169.2 ± 20.7 U/mL vs 106.1 ± 50.3 U/mL, P = 0.002). However, in the group of healthy controls, no differences were seen between those who had been tonsillectomized and subjects who had not been operated on (134.0 ± 52.5 U/mL vs 127.7 ± 48.1 U/mL, P = 0.523). High anti-EBV IgG levels in CD are associated with 5-aminosalicylic acid treatment, tonsillectomy, and decrease of CD19(+) cells.

  20. Software architecture design patterns in Java

    CERN Document Server

    Kuchana, Partha

    2004-01-01

    AN INTRODUCTION TO DESIGN PATTERNSDesign Patterns: Origin and HistoryArchitectural to Software Design PatternsWhat is a Design Pattern?More about Design PatternsAbout This BookUNIFIED MODELING LANGUAGE (UML)UML: A Quick ReferenceClass DiagramsSequence diagramsBASIC PATTERNSInterfaceDescriptionExamplePractice QuestionsAbstract Parent ClassDescriptionExamplePractice QuestionsPrivate MethodsDescriptionExamplePractice QuestionsAccessor MethodsDescriptionAccessor Method NomenclatureExampleDirect Reference versus Accessor MethodsPractice QuestionsConstant Data ManagerDescriptionExamplePractice Quest

  1. Methodology Used to Create System Architecture for its in Slovakia

    Directory of Open Access Journals (Sweden)

    Ales Janota

    2004-01-01

    Full Text Available The paper deals with an object oriented approach proposed by the authors for creation of the ITS system architecture in the Slovak Republic and shows how a reference architecture can be created as s base for future more detailed architectures (models. The authors characterise possible approaches, explain their relations to existing architectures and propose a methodology based on the Unifield Modelling language (UML. The main attention is paid to the logical part (logical view of the system architecture, that should result in the form of easy readable and understandable UML models.

  2. Une approche de réingénierie des systèmes d’information basée sur la génération et l’appariement de spécifications de composants

    Directory of Open Access Journals (Sweden)

    Oualid Khayati

    2005-10-01

    Full Text Available The full potential of components based approaches is reached when large components collections are available to programmers and designers. Reusing components improves software productivity and quality by decreasing development costs, bug risks and development time. A good reuse-oriented information system development environment must be composed of an appropriate components repository. UML diagrams are generally used to document the various sights of a component (dynamic, structural, etc.. This paper presents a technique for formal specifications generation using UML class diagrams. Then, we propose a specification matching technique applied in domains like information system re-engineering, and in components retrieval.

  3. A unified tool for performance modelling and prediction

    International Nuclear Information System (INIS)

    Gilmore, Stephen; Kloul, Leila

    2005-01-01

    We describe a novel performability modelling approach, which facilitates the efficient solution of performance models extracted from high-level descriptions of systems. The notation which we use for our high-level designs is the Unified Modelling Language (UML) graphical modelling language. The technology which provides the efficient representation capability for the underlying performance model is the multi-terminal binary decision diagram (MTBDD)-based PRISM probabilistic model checker. The UML models are compiled through an intermediate language, the stochastic process algebra PEPA, before translation into MTBDDs for solution. We illustrate our approach on a real-world analysis problem from the domain of mobile telephony

  4. Arranging ISO 13606 archetypes into a knowledge base.

    Science.gov (United States)

    Kopanitsa, Georgy

    2014-01-01

    To enable the efficient reuse of standard based medical data we propose to develop a higher level information model that will complement the archetype model of ISO 13606. This model will make use of the relationships that are specified in UML to connect medical archetypes into a knowledge base within a repository. UML connectors were analyzed for their ability to be applied in the implementation of a higher level model that will establish relationships between archetypes. An information model was developed using XML Schema notation. The model allows linking different archetypes of one repository into a knowledge base. Presently it supports several relationships and will be advanced in future.

  5. Benefit of modelling regarding the quality and efficiency of PLC-programming in process automation; Nutzen von Modellierung fuer die Qualitaet und Effizienz der Steuerungsprogrammierung in der Automatisierungstechnik

    Energy Technology Data Exchange (ETDEWEB)

    Friedrich, D; Vogel-Heuser, B [Bergische Univ. Wuppertal (Germany). Lehrstuhl fuer Automatisierungstechnik/Prozessinformatik

    2006-03-15

    Software development in process automation has many deficiencies in procedures, notations and tool support. As a result, modern software engineering concepts and notations, like object oriented approaches or UML, are not wide spread in this field. Hence, drawbacks regarding start-up times, additional costs and low software quality are immense. This paper will evaluate the benefit of modelling as a design step prior to coding, regarding cognitive paradigms. Two modelling notations (UML and ICL) will be compared analyzing their impact on the quality of automation software written in IEC 61131. (orig.)

  6. Refining Nodes and Edges of State Machines

    DEFF Research Database (Denmark)

    Hallerstede, Stefan; Snook, Colin

    2011-01-01

    State machines are hierarchical automata that are widely used to structure complex behavioural specifications. We develop two notions of refinement of state machines, node refinement and edge refinement. We compare the two notions by means of examples and argue that, by adopting simple conventions...... refinement theory and UML-B state machine refinement influences the style of node refinement. Hence we propose a method with direct proof of state machine refinement avoiding the detour via Event-B that is needed by UML-B....

  7. OBJECT ORIENTED MODELLING, A MODELLING METHOD OF AN ECONOMIC ORGANIZATION ACTIVITY

    Directory of Open Access Journals (Sweden)

    TĂNĂSESCU ANA

    2014-05-01

    Full Text Available Now, most economic organizations use different information systems types in order to facilitate their activity. There are different methodologies, methods and techniques that can be used to design information systems. In this paper, I propose to present the advantages of using the object oriented modelling at the information system design of an economic organization. Thus, I have modelled the activity of a photo studio, using Visual Paradigm for UML as a modelling tool. For this purpose, I have identified the use cases for the analyzed system and I have presented the use case diagram. I have, also, realized the system static and dynamic modelling, through the most known UML diagrams.

  8. Positron Emission Tomography with 2-Deoxy-2-[18F] Fluoro-DGlucose in the Detection of Malignancy in Intraductal Papillary Mucinous Neoplasms of the Pancreas

    OpenAIRE

    Brian KP Goh; Yaw-Fui Alexander Chung; David CE Ng; David CE Ng; Khee-Chee Soo

    2007-01-01

    A 79-year-old Indian male was admitted with upper abdominal discomfort of 1-year duration which was associated with loss of weight and appetite. Clinical examination of the abdomen did not reveal any palpable masses. Laboratory investigations including a complete blood count, liver function tests and serum amylase were unremarkable. Standard serum tumor markers were within normal limits: carbohydrate antigen (CA) 19-9, 13.4 U/mL (reference range: 3-45 U/mL); carcinoembryonic antigen (CEA), 1....

  9. Study of a High-Yield Cellulase System Created by Heavy-Ion Irradiation-Induced Mutagenesis of Aspergillus niger and Mixed Fermentation with Trichoderma reesei.

    Directory of Open Access Journals (Sweden)

    Shu-Yang Wang

    Full Text Available The aim of this study was to evaluate and validate the efficiency of 12C6+ irradiation of Aspergillus niger (A. niger or mutagenesis via mixed Trichoderma viride (T. viride culturing as well as a liquid cultivation method for cellulase production via mixed Trichoderma reesei (T. reesei and A. niger culture fermentation. The first mutagenesis approach was employed to optimize yield from a cellulase-producing strain via heavy-ion mutagenesis and high-throughput screening, and the second was to effectively achieve enzymatic hydrolysis of cellulase from a mixed culture of mutant T. viride and A. niger. We found that 12C6+-ion irradiation induced changes in cellulase biosynthesis in A. niger but had no effect on the time course of the synthesis. It is notable that the exoglucanases (CBH activities of A. niger strains H11-1 and H differed (6.71 U/mL vs. 6.01 U/mL and were significantly higher than that of A. niger mutant H3-1. Compared with strain H, the filter paper assay (FPA, endoglucanase (EG and β-glucosidase (BGL activities of mutant strain H11-1 were increased by 250.26%, 30.26% and 34.91%, respectively. A mixed culture system was successfully optimized, and the best ratio of T. reesei to A. niger was 5:1 for 96 h with simultaneous inoculation. The BGL activity of the mixed culture increased after 72 h. At 96 h, the FPA and BGL activities of the mixed culture were 689.00 and 797.15 U/mL, respectively, significantly higher than those of monocultures, which were 408.70 and 646.98 U/mL for T. reesei and 447.29 and 658.89 U/mL for A. niger, respectively. The EG activity of the mixed culture was 2342.81 U/mL, a value that was significantly higher than that of monocultures at 2206.57 U/mL for T. reesei and 1727.62 U/mL for A. niger. In summary, cellulose production and hydrolysis yields were significantly enhanced by the proposed combination scheme.

  10. From State Diagram to Class Diagram

    DEFF Research Database (Denmark)

    Borch, Ole; Madsen, Per Printz

    2009-01-01

    UML class diagram and Java source code are interrelated and Java code is a kind of interchange format. Working with UML state diagram in CASE tools, a corresponding xml file is maintained. Designing state diagrams is mostly performed manually using design patterns and coding templates - a time...... consuming process. This article demonstrates how to compile such a diagram into Java code and later, by reverse engineering, produce a class diagram. The process from state diagram via intermediate SAX parsed xml file to Apache Velocity generated Java code is described. The result is a fast reproducible...

  11. On the Designing of Model Checkers for Real-Time Distributed Systems

    Directory of Open Access Journals (Sweden)

    D. Yu. Volkanov

    2012-01-01

    Full Text Available To verify real-time properties of UML statecharts one may apply a UPPAAL, toolbox for model checking of real-time systems. One of the most suitable ways to specify an operational semantics of UML statecharts is to invoke the formal model of Hierarchical Timed Automata. Since the model language of UPPAAL is based on Networks of Timed Automata one has to provide a conversion of Hierarchical Timed Automata to Networks of Timed Automata. In this paper we describe this conversion algorithm and prove that it is correct w.r.t. UPPAAL query language which is based on the subset of Timed CTL.

  12. Metodología de modelado de aplicaciones web móviles basada en componentes

    OpenAIRE

    Vera, Pablo Martín; Pons, Claudia; González González, Carina Soledad; Giulianelli, Daniel Alberto; Rodríguez, Rocío Andrea

    2013-01-01

    Esta línea de investigación busca crear una metodología de modelado utilizando una extensión conservativa de UML (Lenguaje Unificado de Modelado) que permita diseñar aplicaciones web móviles centrándose en el modelado de la interfaz de usuario mediante la utilización de componente configurables. El objetivo final es la generación automática del código fuente completo de la aplicación. Para lograr tal fin se extienden los diagramas de clases y componentes de UML. El diagrama de clases es exten...

  13. Una propuesta para incorporar más semántica de los modelos al código generado

    OpenAIRE

    Pérez Lovelle, Sonia; Cue Galindo, Julio C.; Hernández Perenzuela, Alexei; Arredondo López, Andry; Recio Nápoles, Luis R.; Carnero González, Frances

    2014-01-01

    Actualmente hay un amplio uso del paradigma Model Driven Architecture (MDA) para la generación de código a partir de modelos, pues esto garantiza menores tiempos de desarrollo y de puesta a punto. Los modelos creados a partir de los diagramas del Lenguaje Unificado de Modelado (UML) son de amplia utilización teniendo en cuenta que se trata de un estándar y además, la gran cantidad de herramientas de modelado que existen para ello. Cada diagrama de UML es un punto de vista diferente del sistem...

  14. Generación automática de aplicaciones web móviles mediante componentes configurables

    OpenAIRE

    Vera, Pablo Martín; Pons, Claudia; González, Carina; Rodríguez, Rocío Andrea; Giulianelli, Daniel Alberto

    2014-01-01

    Teniendo como objetivo final la generación completa del código fuente de una aplicación, se ha desarrollado CBDHM (Metodología de Modelado Hipermedia Basada en Componentes). Esta metodología está basada en UML (Lenguaje Unificado de Modelado) y permite diseñar y construir aplicaciones web móviles utilizando dos modelos: el modelo de datos y el modelo de interfaz de usuario. El modelo de datos está basado en el diagrama de clases UML extendido para poder generar la base de datos y sus relacion...

  15. Workshop on nuclear technology: A joint effort between ANS and the University of Massachusetts-Lowell

    International Nuclear Information System (INIS)

    Brown, G.J.; McDevitt, M.A.; Schmidt, D.

    1992-01-01

    The University of Massachusetts Lowell (UML) (formerly University of Lowell) sponsored, along with the American Nuclear Society (ANS), a 5-day workshop entitled 'Understanding and Teaching about Nuclear Technology and Its Place in Our Society.' More than 30 middle and high school teachers from the New England area (Connecticut, New Hampshire, and Massachusetts) attended the workshop, which was held June 24 through 28, 1991. Based on this experience, and with the expectation of replicating if not improving upon initial success, plans are now under way to offer a similar workshop at UML from June 29 through July 3, 1992

  16. Expressing Model Constraints Visually with VMQL

    DEFF Research Database (Denmark)

    Störrle, Harald

    2011-01-01

    ) for specifying constraints on UML models. We examine VMQL's usability by controlled experiments and its expressiveness by a representative sample. We conclude that VMQL is less expressive than OCL, although expressive enough for most of the constraints in the sample. In terms of usability, however, VMQL......OCL is the de facto standard language for expressing constraints and queries on UML models. However, OCL expressions are very difficult to create, understand, and maintain, even with the sophisticated tool support now available. In this paper, we propose to use the Visual Model Query Language (VMQL...

  17. On the Impact of Diagram Layout: How Are Models Actually Read?

    DEFF Research Database (Denmark)

    Störrle, Harald; Baltsen, Nick; Christoffersen, Henrik

    2014-01-01

    This poster presents the latest results from a very large eye tracking study (n=29) that explores how modelers read UML diagrams. We find that various factors like layout quality, modeler experience, and diagram type lead to significant differences in diagram reading strategies. We derive elements...

  18. Effect of immobile isolated enzymes from rumen liquid by using alginate matrices on the bay leaf extraction

    Science.gov (United States)

    Paramita, Vita; Yulianto, Mohammad Endy; Yohana, Eflita; Arifan, Fahmi; Hanifah, Amjad, Muhammad Taqiyuddin

    2015-12-01

    This research aims to develop the enzymatically of bay leaves phytochemical extraction process. The novelty and the main innovations of this research is the development of extraction process by using enzymatic extractor and isolate the enzymes from rumen liquid to shift the equilibrium phase, increase the extraction rate and increase the extraction yield. The activity of rumen liquid enzyme was represented by the activity of cellulase and protease. The analyze of total flavonoid content was performed by using UV-Vis Spectrofometry. The activity of immobilized enzyme of cellulase (0.08±0.00 U/ml) was lower than the un-immobilized one (0.23±0.00 U/ml). However, there was no difference activity of the immobilized (0.75±0.00 U/ml) and un-immobilized (0.76±0.01 U/ml) of protease. The model of mass transfer of un-immobilized enzyme can be fitted on the experimental data, however the model of mass transfer of immobilized enzyme did not match with the experimental data. The mass transfer coefficient of enzymatic extraction flavonoids bay leaf without immobilization was 0.17167 s-1 which greater than the reported value of obtained KLa from extraction by using electric heating.

  19. Software specification methods

    CERN Document Server

    Habrias, Henri

    2010-01-01

    This title provides a clear overview of the main methods, and has a practical focus that allows the reader to apply their knowledge to real-life situations. The following are just some of the techniques covered: UML, Z, TLA+, SAZ, B, OMT, VHDL, Estelle, SDL and LOTOS.

  20. Architectural Design of a LMS with LTSA-Conformance

    Science.gov (United States)

    Sengupta, Souvik; Dasgupta, Ranjan

    2017-01-01

    This paper illustrates an approach for architectural design of a Learning Management System (LMS), which is verifiable against the Learning Technology System Architecture (LTSA) conformance rules. We introduce a new method for software architectural design that extends the Unified Modeling Language (UML) component diagram with the formal…

  1. Dakin Solution Alters Macrophage Viability and Function

    Science.gov (United States)

    2014-07-18

    fungi, viruses, and parasites [1]. Dakin’s solution (DS) is buffered sodium hypochlorite, which has a long history of use as a topical antiseptic in...eagle medium (DMEM) supplemented with 10% fetal bovine serum, 10 U/mL penicillin, 10 mg/mL streptomycin, and maintained at 37C in 5% CO2. DS (buffered

  2. Suitability of Invertebrate and Vertebrate Cells in a Portable Impedance-Based Toxicity Sensor: Temperature Mediated Impacts on Long-Term Survival

    Science.gov (United States)

    2013-07-25

    Scientific HyClone, Logan, UT) supplemented with 10% fetal bovine serum (FBS; Sigma–Aldrich, St. Louis, MO), 200 U/mL penicillin (Thermo Scientific HyClone...Richman, A., Hans-Michael, M., Kaftos, F.C., 1997. Molecular immune responses of the mosquito anopheles gambiae to bacteria and malaria parasites

  3. Spatial dimensions of land administration and user rights over groundwater : Case study of Kerala, India vs. Coca Cola

    NARCIS (Netherlands)

    Ghawana, T.; Hespanha, J.P.; Zevenbergen, J.A.; Van Oosterom, P.J.M.

    2011-01-01

    Supporting the management of rights related to groundwater based on input from hydrogeology software is contributing to bridging the gap between the technical and administrative aspects of groundwater management. The research reported herein is focused on a specific example (or ‘use case’ in UML

  4. Model-Based GUI Testing Using Uppaal at Novo Nordisk

    DEFF Research Database (Denmark)

    H. Hjort, Ulrik; Rasmussen, Jacob Illum; Larsen, Kim Guldstrand

    2009-01-01

    This paper details a collaboration between Aalborg University and Novo Nordiskin developing an automatic model-based test generation tool for system testing of the graphical user interface of a medical device on an embedded platform. The tool takes as input an UML Statemachine model and generates...

  5. Ontology Based Model Transformation Infrastructure

    NARCIS (Netherlands)

    Göknil, Arda; Topaloglu, N.Y.

    2005-01-01

    Using MDA in ontology development has been investigated in several works recently. The mappings and transformations between the UML constructs and the OWL elements to develop ontologies are the main concern of these research projects. We propose another approach in order to achieve the collaboration

  6. 一种基于并行对象的可视化描述%A Visual Description Based on Concurrent Objects

    Institute of Scientific and Technical Information of China (English)

    黄永忠; 李国巨; 郭金庚

    2001-01-01

    This paper puts forward a visual concurrent programming model based on concurrent objects,which absorbs the basic thought of UML,class diagram is used to describe concurrent classes,shared classes ,general classes in SPC++ and the relationships among these olasses. Through the visual description system can generate the code framework automatically.

  7. Optimization of mutanase production by Trichoderma harzianum ...

    African Journals Online (AJOL)

    PROMOTING ACCESS TO AFRICAN RESEARCH ... The highest enzyme activity (0.747 U/mL) was reached in shaken flask cultures ... increase in the production of mutanase compared with the culture before optimization. ... Keywords: Mutanase, Trichoderma harzianum, response surface methodology (RSM), bioreactors, ...

  8. A New Tool to Facilitate Learning Reading for Early Childhood

    Science.gov (United States)

    Puspitasari, Cita; Subiyanto

    2017-01-01

    This paper proposes a new android application for early childhood learning reading. The description includes a design, development, and an evaluation experiment of an educational game for learning reading on android. Before developing the game, Unified Modeling Language (UML) diagrams, interfaces, animation, narrative or audio were designed.…

  9. Rosen's (M,R) system in Unified Modelling Language.

    Science.gov (United States)

    Zhang, Ling; Williams, Richard A; Gatherer, Derek

    2016-01-01

    Robert Rosen's (M,R) system is an abstract biological network architecture that is allegedly non-computable on a Turing machine. If (M,R) is truly non-computable, there are serious implications for the modelling of large biological networks in computer software. A body of work has now accumulated addressing Rosen's claim concerning (M,R) by attempting to instantiate it in various software systems. However, a conclusive refutation has remained elusive, principally since none of the attempts to date have unambiguously avoided the critique that they have altered the properties of (M,R) in the coding process, producing merely approximate simulations of (M,R) rather than true computational models. In this paper, we use the Unified Modelling Language (UML), a diagrammatic notation standard, to express (M,R) as a system of objects having attributes, functions and relations. We believe that this instantiates (M,R) in such a way than none of the original properties of the system are corrupted in the process. Crucially, we demonstrate that (M,R) as classically represented in the relational biology literature is implicitly a UML communication diagram. Furthermore, since UML is formally compatible with object-oriented computing languages, instantiation of (M,R) in UML strongly implies its computability in object-oriented coding languages. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  10. The unified coordination language UnCL.

    NARCIS (Netherlands)

    F.S. de Boer (Frank); J.V. Guillen Scholten (Juan); J.F. Jacob (Joost)

    2005-01-01

    textabstractIn this paper we show how to use a (subset) of UML as an Unified Coordination Language (UnCL) that is based on a separation of concerns between coordination and computation. As such UnCL provides a general language for the coordination of, in particular, object-oriented applications. The

  11. Identification of lipolytic enzymes isolated from bacteria indigenous to Eucalyptus wood species for application in the pulping industry

    CSIR Research Space (South Africa)

    Ramnath, L

    2017-09-01

    Full Text Available ) and characterized. Phenol red agar plates supplemented with 1% olive oil or tributyrin was ascertained to be the most favourable method of screening for lipolytic activity. Lipolytic activity of the various enzymes were highest at 45–61 U/ml at the optimum...

  12. Modelling and Implementation of Catalogue Cards Using FreeMarker

    Science.gov (United States)

    Radjenovic, Jelen; Milosavljevic, Branko; Surla, Dusan

    2009-01-01

    Purpose: The purpose of this paper is to report on a study involving the specification (using Unified Modelling Language (UML) 2.0) of information requirements and implementation of the software components for generating catalogue cards. The implementation in a Java environment is developed using the FreeMarker software.…

  13. Modeling Software Evolution using Algebraic Graph Rewriting

    NARCIS (Netherlands)

    Ciraci, Selim; van den Broek, Pim

    We show how evolution requests can be formalized using algebraic graph rewriting. In particular, we present a way to convert the UML class diagrams to colored graphs. Since changes in software may effect the relation between the methods of classes, our colored graph representation also employs the

  14. The Two Faces of Selective Memory Retrieval: Recall Specificity of the Detrimental but Not the Beneficial Effect

    Science.gov (United States)

    Bäuml, Karl-Heinz T.; Dobler, Ina M.

    2015-01-01

    Depending on the degree to which the original study context is accessible, selective memory retrieval can be detrimental or beneficial for the recall of other memories (Bäuml & Samenieh, 2012). Prior work has shown that the detrimental effect of memory retrieval is typically recall specific and does not arise after restudy trials, whereas…

  15. Production and characterization of thermostable xylanase from ...

    African Journals Online (AJOL)

    ajl2

    2013-02-20

    Feb 20, 2013 ... Penicillium, .... production in liquid medium ranged from 0.11 to 0.21. U/ml (data not shown). ... Lane 2 represents the negative control (Bacillus sp.). Lane 3 is .... circulans D1 in submerged fermentation using response surface.

  16. A Unified Toolset for Business Process Model Formalization

    NARCIS (Netherlands)

    B. Changizi (Behnaz); N. Kokash (Natallia); F. Arbab (Farhad)

    2010-01-01

    htmlabstractIn this paper, we present a toolset to automate the transformation of Business Process Modeling Notation (BPMN), UML Sequence Diagrams, and Business Process Execution Language (BPEL), into their proposed formal semantics expressed in the channel-based coordination language Reo. Such

  17. Celiac disease: Serologic prevalence in patients with irritable bowel syndrome

    Directory of Open Access Journals (Sweden)

    Zobeiri Mehdi

    2012-01-01

    Full Text Available Background: The prevalence of irritable bowel syndrome (IBS in the community is 10%-20% and have symptom based diagnostic criteria. Many symptoms of celiac disease (CD with 1% prevalence in some communities can mimic IBS. Sensitive and specific serologic tests of CD can detect asymptomatic cases. The purpose of this study was to compare the level of anti-tissue-transglutaminase (tTG IgA in IBS patients and controls group. Materials and Methods: This case-control study was performed at a University hospital in which 107 patients with IBS who met the Rome II criteria for their diagnosis were compared with 126 healthy age and sex-matched controls. Both groups were investigated for CD by analysis of their serum tTG IgA antibody with human recombinant antigen. Titers were positive containing over 10u/ml and borderline if they were between 4 and 10 u/ml. Result: 86 percent of IBS patients were female. The mean antibody level was 0.837 u/ml in IBS group and 0.933 u/ml in control group without any significant difference. Discussion and Conclusion: Results of this study may intensify disagreement on the situation of CD in IBS patients.

  18. Isolation of α-amylase from malted rice (Wita 7) extract using ...

    African Journals Online (AJOL)

    The crude α-amylase from the 8th day malt extract was subsequently purified using starch column procedure. The purified extract recorded an estimated activity of 75.549 U/ml. The project further examined the effects of varying the ratios of starch adsorbent height to column diameter (L/D) during the purification step. For the ...

  19. Basolateral Cl- channels in the larval bullfrog skin epithelium

    DEFF Research Database (Denmark)

    Hillyard, Stanley D.; Rios, K.; Larsen, Erik Hviid

    2002-01-01

    The addition of 150 U/ml nystatin to the mucosal surface of isolated skin from larval bullfrogs increases apical membrane permeability and allows a voltage clamp to be applied to the basolateral membrane. With identical Ringer's solutions bathing either side of the tissue the short-circuit curren...

  20. Extraction of state machines of legacy C code with Cpp2XMI

    NARCIS (Netherlands)

    Brand, van den M.G.J.; Serebrenik, A.; Zeeland, van D.; Serebrenik, A.

    2008-01-01

    Analysis of legacy code is often focussed on extracting either metrics or relations, e.g. call relations or structure relations. For object-oriented programs, e.g. Java or C++ code, such relations are commonly represented as UML diagrams: e.g., such tools as Columbus [1] and Cpp2XMI [2] are capable

  1. An object-oriented framework for managing cooperating legacy databases

    NARCIS (Netherlands)

    Balsters, H; de Brock, EO

    2003-01-01

    We describe a general semantic framework for precise specification of so-called database federations. A database federation provides for tight coupling of a collection of heterogeneous legacy databases into a global integrated system. Our approach to database federation is based on the UML/OCL data

  2. Proposed Framework which Uses Object Oriented Principles in Relational Systems: Structure and Formating (Part 2

    Directory of Open Access Journals (Sweden)

    Catalin STRIMBEI

    2006-01-01

    Full Text Available Our approach tries to overcome the limitations of so called “flat nature” of relational systems, in the actual context of actual relational database theories, database systems technologies and object oriented methodologies by proposing an MDA framework to map an object oriented (UML formalized model to object-relational structures of today’s database systems.

  3. Embedding object-oriented design in system engineering

    NARCIS (Netherlands)

    Wieringa, Roelf J.; Kilov, H.; Rumpe, B.; Simmonds, I.

    1999-01-01

    The Unified Modeling Language (UML) is a collection of techniques intended to document design decisions about software. This contrasts with systems engineering approaches such as for example Statemate and the Yourdon Systems Method (YSM), in which the design of an entire system consisting of

  4. Production of extracellular lipase by a new strain Staphylococcus ...

    African Journals Online (AJOL)

    Based on morphological, biochemical and 16S rRNA sequence analysis, the potent isolate was identified as Staphylococcus aureus. The lipase production of the isolate was increased by improving the conditions of production medium. Maximum lipase production (8.11 U/ml) was achieved when 2% punnakka oil was ...

  5. Translating message sequence charts to other process languages using process mining

    NARCIS (Netherlands)

    Lassen, K.B.; Dongen, van B.F.; Jensen, K.; Aalst, van der W.M.P.; Billington, J.

    2008-01-01

    Message Sequence Charts (MSCs) are often used by software analysts when discussing the behavior of a system with different stakeholders. Often such discussions lead to more complete behavioral models in the form of, e.g., Event-driven Process Chains (EPCs), Unified Modeling Language (UML), activity

  6. Complexity metrics for workflow nets

    NARCIS (Netherlands)

    Lassen, K.B.; Aalst, van der W.M.P.

    2009-01-01

    Process modeling languages such as EPCs, BPMN, flow charts, UML activity diagrams, Petri nets, etc., are used to model business processes and to configure process-aware information systems. It is known that users have problems understanding these diagrams. In fact, even process engineers and system

  7. Towards an Operationalization of the “Physics of Notations” for the Analysis of Visual Languages

    DEFF Research Database (Denmark)

    Störrle, Harald; Fish, Andrew

    2013-01-01

    We attempt to validate the conceptual framework “Physics of Notation” (PoN) as a means for analysing visual languages by applying it to UML Use Case Diagrams. We discover that the PoN, in its current form, is neither precise nor comprehensive enough to be applied in an objective way to analyse...

  8. Model driven development of user interface prototypes

    DEFF Research Database (Denmark)

    Störrle, Harald

    2010-01-01

    the whole UI development life cycle, connect all stakeholders involved, and support a wide range of levels of granularity and abstraction. This is achieved by using Window/Event-Diagrams (WEDs), a UI specification notation based on UML 2 state machines. It affords closer collaboration between different user...

  9. Serum selenium is low in newly diagnosed Graves´disease: a population-based study

    DEFF Research Database (Denmark)

    Bülow Pedersen, Inge; Knudsen, Nils; Carle, Allan

    2013-01-01

    by a fluorimetric method. Patients with newly diagnosed Graves’ disease (GD) (n = 97) or autoimmune overt hypothyroidism (AIH) (n = 96), euthyroid subjects with high serum levels of thyroid peroxidase antibody (TPO‐Ab) (TPO‐Ab > 1500 U/ml, n = 92) and random controls (n = 830). Differences in s‐Se values. S...

  10. Comparison of Plasma Tu-M2-PK and CA19-9 in Pancreatic Cancer

    DEFF Research Database (Denmark)

    Joergensen, Maiken Thyregod; Heegaard, Niels H H; Schaffalitzky de Muckadell, Ove B

    2009-01-01

    because of suspicion of pancreatic cancer. Of these, 51 patients had their conditions diagnosed as PDAC, whereas this diagnosis was ruled out in 52 after 12 months of follow-up. The performance of Tu-M2-PK was compared with that of CA19-9 using cutoff values 15 and 37 U/mL, respectively. RESULTS...

  11. Filamentous fungi and agro-industrial residues selection for enzyme production of biotechnological interestSeleção de fungos filamentosos e de resíduos agroindustriais para a produção de enzimas de interesse biotecnológico

    Directory of Open Access Journals (Sweden)

    Erivelton César Stroparo

    2012-12-01

    Full Text Available Many fungal enzymes have relevant applications in different industrial areas. The objective of this work was to select fungi producing hydrolytic enzymes, as well as establish agro-industrial wastes capable of inducing higher production levels. Xylanase, endoglucanase, amylase and poligalacturonase activities were determined by incubating the culture filtrates with their respective substrates. Subsequently, the reducing sugars determination was carried out using 3,5-dinitrosalicylic acid reagent.The protein determination was performed according the modified Bradford method. Among the fungal strains evaluated, Aspergillus niger J4 showed higher levels of xylanase production (8.73 ± 0.34 U/ml and this was greatest when brewer’s spent grain was used as substrate (9.80 ± 0.02 U/ml. Penicillium miczynskii produced the highest levels of endoglucanasic activity (0.13 ± 0.03 U/ml, which, in turn, was favored in the pineapple peel presence (0.18 ± 0.02 U/ml. In relation to amylase, A. niger J26 was selected as the best producer strain (6.10 ± 0.30 U/ml with wheat bran as the best substrate for their production (7.32 ± 0.14 U/ml. Penicillium verruculosum exhibited the highest level of poligalacturonase activity (8.65 ± 0.12 U/ml, especially when grown in orange peel presence (10.32 ± 0.10 U/ml. These wastes use in these enzymes production may not only reduce their production cost, but also substantially reduce the environmental impact caused by the deposition of these wastes on the environment.Muitas enzimas produzidas por fungos têm relevantes aplicações em diferentes áreas industriais. O objetivo deste trabalho foi selecionar fungos filamentosos produtores de enzimas hidrolíticas, bem como estabelecer os resíduos agroindustriais capazes de induzir maiores níveis de produção. As atividades xilanásica, endoglucanásica, amilásica e poligalacturonásica foram determinadas incubandose os filtrados de cultura com seus respectivos

  12. Graph and model transformation tools for model migration : empirical results from the transformation tool contest

    NARCIS (Netherlands)

    Rose, L.M.; Herrmannsdoerfer, M.; Mazanek, S.; Van Gorp, P.M.E.; Buchwald, S.; Horn, T.; Kalnina, E.; Koch, A.; Lano, K.; Schätz, B.; Wimmer, M.

    2014-01-01

    We describe the results of the Transformation Tool Contest 2010 workshop, in which nine graph and model transformation tools were compared for specifying model migration. The model migration problem—migration of UML activity diagrams from version 1.4 to version 2.2—is non-trivial and practically

  13. High pre-transplant soluble CD30 levels are predictive of the grade of rejection.

    Science.gov (United States)

    Rajakariar, Ravindra; Jivanji, Naina; Varagunam, Mira; Rafiq, Mohammad; Gupta, Arun; Sheaff, Michael; Sinnott, Paul; Yaqoob, M M

    2005-08-01

    In renal transplantation, serum soluble CD30 (sCD30) levels in graft recipients are associated with increased rejection and graft loss. We investigated whether pre-transplant sCD30 concentrations are predictive of the grade of rejection. Pre-transplant sera of 51 patients with tubulointerstitial rejection (TIR), 16 patients with vascular rejection (VR) and an age-matched control group of 41 patients with no rejection (NR) were analyzed for sCD30. The transplant biopsies were immunostained for C4d. The median sCD30 level was significantly elevated in the group with VR (248 Units (U)/mL, range: 92-802) when compared with TIR (103 U/mL, range: 36-309, psCD30 levels compared to NR. Based on C4d staining, a TH2 driven process, the median sCD30 levels were significantly raised in C4d+ patients compared with C4d- group (177 U/mL vs. 120 U/mL, psCD30 levels measured at time of transplantation correlate with the grade of rejection. High pre-transplant levels are associated with antibody-mediated rejection which carries a poorer prognosis. sCD30 could be another tool to assess immunological risk prior to transplantation and enable a patient centered approach to immunosuppression.

  14. Evaluation of serum sCD30 in renal transplantation patients with and without acute rejection.

    Science.gov (United States)

    Cervelli, C; Fontecchio, G; Scimitarra, M; Azzarone, R; Famulari, A; Pisani, F; Battistoni, C; Di Iulio, B; Fracassi, D; Scarnecchia, M A; Papola, F

    2009-05-01

    Despite new immunosuppressive approaches, acute rejection episodes (ARE) are still a major cause of early kidney dysfunction with a negative impact on long-term allograft survival. Noninvasive markers able to identify renal ARE earlier than creatinine measurement include sCD30. We sought to establish whether circulating levels of sCD30 in pretransplantation and posttransplantation periods were of clinical relevance to avoid graft damage. Quantitative detection of serum sCD30 was performed using an enzyme-linked immunosorbent assay. Our results demonstrated that the mean concentrations of sCD30 were significantly higher in the sera of renal transplant recipients with ARE (30.04 U/mL) and in uremic patients on the waiting list (37.7 U/mL) compared with healthy controls (HC; 9.44 U/mL), but not nonrejecting patients (12.01 U/mL). Statistical analysis revealed a strong association between high sCD30 levels in posttransplantation sera and ARE risk. This study suggested that sCD30 levels were a reliable predictor of ARE among deceased-donor kidney recipients.

  15. From StoCharts to MoDeST: a comparative reliability analysis of train radio communications

    NARCIS (Netherlands)

    Hermanns, H.; Jansen, D.N.; Usenko, Y.S.

    StoCharts have been proposed as a UML statechart extension for performance and dependability evaluation, and have been applied in the context of train radio reliability assessment to show the principal tractability of realistic cases with this approach. In this paper, we extend on this bare

  16. A comparative reliability analysis of ETCS train radio communications

    NARCIS (Netherlands)

    Hermanns, H.; Becker, B.; Jansen, D.N.; Damm, W.; Usenko, Y.S.; Fränzle, M.; Olderog, E.-R.; Podelski, A.; Wilhelm, R.

    StoCharts have been proposed as a UML statechart extension for performance and dependability evaluation, and were applied in the context of train radio reliability assessment to show the principal tractability of realistic cases with this approach. In this paper, we extend on this bare feasibility

  17. A comparative realiability analysis of ETCS train radio communications

    NARCIS (Netherlands)

    Hermanns, H.; Jansen, D.N.; Usenko, Y.S.

    2005-01-01

    StoCharts have been proposed as a UML statechart extension for performance and dependability evaluation, and were applied in the context of train radio reliability assessment to show the principal tractability of realistic cases with this approach. In this paper, we extend on this bare feasibility

  18. Identification and characterization of glucoamylase from the fungus, Thermomyces lanuginosus

    DEFF Research Database (Denmark)

    Thorsen, Thor Seneca; Johnsen, Anders; Josefsen, K.

    2006-01-01

    the thermophilic fungus Talaromyces emersonii. cDNA encoding Thermomyces lanuginosus glucoamylase was expression cloned into Pichia pastoris, producing approximately 7.4 U/ml. It was concluded that alternative mRNA splicing as it might occur in Aspergillus niger glucoamylase is not responsible for the occurrence...

  19. Effect of Nitrogen and Carbon Sources on Lipase Production by Penicillium aurantiogriseum

    Directory of Open Access Journals (Sweden)

    Valéria M. G. Lima

    2003-01-01

    Full Text Available A wild fungal strain isolated from soybean oil and identified as Penicillium aurantiogriseum initially presented a volumetric lipase activity of 0.4 U/mL in submerged culture in a medium containing 0.5 % yeast extract and 1 % olive oil. Studies were undertaken to improve lipase production. The effect of nitrogen source was studied by adding casein peptone, meat peptone, yeast extract or ammonium sulfate to a medium containing potassium nitrate and other mineral salts. The best yield, of 13 U/mL after 72 h, was obtained with the medium supplemented with ammonium sulfate. With the ammonium sulfate concentration increased to double the C/N ratio from 2.5 to 5, a lipolytic activity of 18 U/mL was obtained. Olive, corn, soy and sunflower oils were tested as carbon sources in this medium, with olive oil at 1 % giving a lipolytic activity of 25 U/mL after 48 h, the highest yield obtained in this study. Enzyme production was best at 29 °C, within a range tested from 26 to 32 °C. These results are promising because this strain produces lipase in an inexpensive inorganic medium and we succeeded in increasing the lipolytic activity 62-fold over the initial values obtained with the non-optimized medium.

  20. Enzymatic activity of a novel halotolerant lipase from Haloarcula hispanica 2TK2

    Directory of Open Access Journals (Sweden)

    Ozgen Melis

    2016-06-01

    Full Text Available A strain of Haloarcula hispanica isolated from Tuzkoy salt mine, Turkey exhibited extracellular lipolytic activity. Important parameters such as carbon sources and salt concentration for lipase production were investigated. Optimal conditions for the enzyme production from Haloarcula hispanica 2TK2 were determined. It was observed that the lipolytic activity of Haloarcula hispanica was stimulated by some of the carbon sources. The high lipase acitivity values were obtained in the presence of 2% (v/v walnut oil (6.16 U/ml, 1% (v/v fish oil (5.07 U/ml, 1% (v/v olive oil (4.52 U/ml and 1% (w/v stearic acid (4.88 U/ml at 4M NaCl concentration. Lipase was partially purified by ammonium sulfate precipitation and ultrafiltration. Optimal temperature and pH values were determined as 45°C and 8.0, respectively. Lipase activity decreased with the increasing salt concentration, but 85% activity of the enzyme was maintained at 5M NaCl concentration. The enzyme preserved 41% of its relative activity at 90°C. The partially purified lipase maintained its activity in the presence of surfactants such as Triton X-100 and SDS. Therefore, the lipase which is an extremozyme may have potential applications especially in detergent industry.

  1. Alteration of white-rot basidiomycetes cellulase and xylanase activities in the submerged co-cultivation and optimization of enzyme production by Irpex lacteus and Schizophyllum commune.

    Science.gov (United States)

    Metreveli, Eka; Kachlishvili, Eva; Singer, Steven W; Elisashvili, Vladimir

    2017-10-01

    Mono and dual cultures of four white-rot basidiomycete species were evaluated for cellulase and xylanase activity under submerged fermentation conditions. Co-cultivation of Pycnoporus coccineus or Trametes hirsuta with Schizophyllum commune displayed antagonistic interactions resulting in the decrease of endoglucanase and total cellulase activities. In contrast, increases in cellulase and xylanase activity were revealed through the compatible interactions of Irpex lacteus with S. commune. Co-cultivation conditions were optimized for maximum enzyme production by I. lacteus and S. commune, the best producers of cellulase/xylanase and β-glucosidase, respectively. An optimized medium for the target enzyme production by the mixed culture was established in a laboratory fermenter yielding 7U/mL total cellulase, 142U/mL endoglucanase, 104U/mL xylanase, and 5.2U/mL β-glucosidase. The dual culture approach resulted in an enzymatic mixture with 11% improved lignocellulose saccharification potential compared to enzymes from a monoculture of I. lacteus. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Developing a Philippine Cancer Grid. Part 1: Building a Prototype for a Data Retrieval System for Breast Cancer Research Using Medical Ontologies

    Science.gov (United States)

    Coronel, Andrei D.; Saldana, Rafael P.

    Cancer is a leading cause of morbidity and mortality in the Philippines. Developed within the context of a Philippine Cancer Grid, the present study used web development technologies such as PHP, MySQL, and Apache server to build a prototype data retrieval system for breast cancer research that incorporates medical ontologies from the Unified Medical Language System (UMLS).

  3. User oriented definition of product requirements within mechatronic engineering

    OpenAIRE

    Gerst, M.;Gierhardt, H.;Braun, T.

    2017-01-01

    In this paper the application of a modeling technique from software engineering to mechatronic engineering is presented. The Unified Modeling Language (UML) is used to model users´ needs and relate them to product requirements. Within a bus seat development project a Use Case Model and an Analyses Model were elaborated. Advantages and Disadvantages of the presented procedure are shown.

  4. Download this PDF file

    African Journals Online (AJOL)

    Pl“()(lll.lCli0U of testosterone uml oestrogen is controlled by the jiiitttitory release ol' the leiiteitnsing hormones (Lil). 'l'l'ie administration of testosterone and oestrogen or their. analogues, suppresses the release of Lt! by a negative feedback mechanism. The ii'iechanism of the hot flushes is wtiiclezit'2 although it is known to ...

  5. Extending Profiles with Stereotypes for Composite Concepts

    NARCIS (Netherlands)

    Quartel, Dick; Dijkman, R.M.; van Sinderen, Marten J.; Briand, L.; Williams, C.

    2005-01-01

    This paper proposes an extension of the UML 2.0 profiling mechanism. This extension facilitates a language designer to introduce composite concepts as separate conceptual and notational elements in a modelling language. Composite concepts are compositions of existing concepts. To facilitate the

  6. A Systems Analysis and Design Case Study for a Business Modeling Learning Experience for a Capstone CIS/IS Systems Development Class

    Science.gov (United States)

    Russell, Jack; Russell, Barbara

    2015-01-01

    The goal is to provide a robust and challenging problem statement for a capstone, advanced systems analysis and design course for CIS/MIS/CS majors. In addition to the problem narrative, a representative solution for much of the business modeling deliverables is presented using the UML paradigm. A structured analysis deliverable will be the topic…

  7. Michaelis kinetic analysis of extracellular cellulase and amylase excreted by Lactobacillus plantarum during cassava fermentation

    Science.gov (United States)

    Frediansyah, Andri; Kurniadi, Muhamad

    2017-01-01

    Our previous study reveal that single culture of Lactobacillus plantarum has ability to ferment cassava tuber in relation to produce modified cassava flour (mocaf). It was used to accelerate a fermentation process. L. plantarum grow well and produce some extracellular enzymes i.e. cellulase to change the structure and breakdown the cell wall of cassava tuber. Then, the starchy materials will be hydrolyzed by i.e. amylase into simple sugar and convert to organic acid. All of these process will give new characteristic of cassava i.e. lower fiber content, good flavor, taste, aroma and texture and the amount of cyanide acid is lower. Therefore this present study was to analyze Michaelis kinetics of extracellular carboxymethyl cellulase and amylase production by L. plantarum during cassava fermentation. The maximum carboxymethyl cellulase and amylase activity of 8.60 U/ml and 14.07 U/ml, respectively, were obtained from filtrate which has been incubated at 37°C for 18 h under stationary conditions. The Vmax and Km of CMCase were 0.8506 × 10-3 U/ml and 0.9594 × 10-3 g/mL, respectively. For amylase were 9.291 × 10-3 U/ml and 0.9163 × 10-3 g/ml, respectively.

  8. A note on the translation of conceptual data models into description logics: disjointness and covering assumptions

    CSIR Research Space (South Africa)

    Casini, G

    2012-10-01

    Full Text Available possibilities for conceptual data modeling. It also raises the question of how existing conceptual models using ER, UML or ORM could be translated into Description Logics (DLs), a family of logics that have proved to be particularly appropriate for formalizing...

  9. Xylanase production from Thermomyces lanuginosus VAPS-24 using low cost agro-industrial residues via hybrid optimization tools and its potential use for saccharification.

    Science.gov (United States)

    Kumar, Vishal; Chhabra, Deepak; Shukla, Pratyoosh

    2017-11-01

    The xylanase production from Thermomyces lanuginosus VAPS-24 has been optimized using OFAT (One factor at a time) approach using agro-industrial substrates. Further, central composite design (CCD) has been employed to optimize various process parameters such as temperature (45-55°C), carbon source concentration (1.5-2.5%), fermentation time (72-120h) and production medium pH (6-8). Maximum xylanase yield after RSM optimization was approximately double (119.91±2.53UmL -1 ) than un-optimized conditions (61.09±0.91UmL -1 ). Several hybrid statistical tools such as Genetic Algorithm-Response Surface Methodology (GA-RSM), Artificial Neural Network (ANN), Genetic Algorithm-Artificial Neural Network (GA-ANN) were employed to obtain more optimized process parameters to maximize the xylanase production and observed an increase of 10.50% xylanase production (132.51±3.27UmL -1 ) as compared to RSM response (119.91±2.53UmL -1 ). The various pretreated and untreated agricultural residues were subjected to saccharification by using crude xylanase in which the pretreated rice straw yielded maximum fermentable sugars 126.89mgg -1 . Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. AADL and Model-based Engineering

    Science.gov (United States)

    2014-10-20

    pictures – MDE and MDA with UML – Automatically generated documents We need language for architecture modeling • Strongly typed • Well-defined...Mail Software Engineering Institute Customer Relations 4500 Fifth Avenue Pittsburgh, PA 15213-2612 USA Web Wiki.sei.cmu.edu/aadl www.aadl.info

  11. An Incremental Life-cycle Assurance Strategy for Critical System Certification

    Science.gov (United States)

    2014-11-04

    Current practice: software modeling close to source code – Remember software through pictures – MDE and MDA with UML – Automatically generated documents...U.S. Mail Software Engineering Institute Customer Relations 4500 Fifth Avenue Pittsburgh, PA 15213-2612 USA Web Wiki.sei.cmu.edu/aadl

  12. Translating Message Sequence Charts to other Process Languages using Process

    DEFF Research Database (Denmark)

    Lassen, Kristian Bisgaard; van Dongen, Boudewijn F.

    2008-01-01

    stakeholders. Often such discussions lead to more complete behavioral models described by e.g. Event-driven Process Chains (EPCs), UML activity diagrams, BPMN models, Petri nets, etc. Process mining on the other hand, deals with the problem of constructing complete behavioral models by analyzing event logs...

  13. Complexity Metrics for Workflow Nets

    DEFF Research Database (Denmark)

    Lassen, Kristian Bisgaard; van der Aalst, Wil M.P.

    2009-01-01

    Process modeling languages such as EPCs, BPMN, flow charts, UML activity diagrams, Petri nets, etc.\\ are used to model business processes and to configure process-aware information systems. It is known that users have problems understanding these diagrams. In fact, even process engineers and system...

  14. A lightweight approach for designing enterprise architectures using BPMN : an application in hospitals

    NARCIS (Netherlands)

    Barros, O.; Seguel Pérez, R.E.; Quezada, A.; Dijkman, R.; Hofstetter, J.; Koehler, J.

    2011-01-01

    An Enterprise Architecture (EA) comprises different models at different levels of abstraction. Since existing EA design approaches, e.g. MDA, use UML for modeling, the design of the architecture becomes complex and time consuming. In this paper, we present an integrated and lightweight design

  15. An Analysis of SE and MBSE Concepts to Support Defence Capability Acquisition

    Science.gov (United States)

    2014-09-01

    Architecture Review Meeting ATM Automatic Teller Machine AUSDAF Australian Defence Architecture Framework (also known as DAF) BOK Body of Knowledge BPMN ...behaviour trees, • business process modelling notation ( BPMN ™), • flowcharts, • IDEFx™ family of diagrams, and • Architecture Description...model diagraming of the ilk of BPMN , UML and SysML33 is heavily rules- 32 Architecture

  16. Experiences in enhancing existing BPM Tools with BPEL Import and Export

    DEFF Research Database (Denmark)

    Mendling, Jan; Lassen, Kristian Bisgaard; Zdun, Uwe

    2006-01-01

    utilize graph-based BPM languages such as EPCs, Workflow Nets, UML Activity Diagrams, and BPMN in their modeling component while BPEL is rather a block-oriented language inspired by process calculi. In this paper we identify transformation strategies as reusable solutions for mapping control flow between...

  17. Translating Message Sequence Charts to other Process Languages using Process Mining

    DEFF Research Database (Denmark)

    Lassen, Kristian Bisgaard; van Dongen, Boudewijn; van der Aalst, Wil M. P.

    stakeholders. Often such discussions lead to more complete behavioral models described by e.g.\\ Event-driven Process Chains (EPCs), UML activity diagrams, BPMN models, Petri nets, etc. The contribution of this paper is to present a method that uses process mining to translate a set of MSCs that represent...

  18. Immunogenicity and safety of the Vi-CRM197 conjugate vaccine against typhoid fever in adults, children, and infants in south and southeast Asia: results from two randomised, observer-blind, age de-escalation, phase 2 trials.

    Science.gov (United States)

    Bhutta, Zulfiqar A; Capeding, Maria Rosario; Bavdekar, Ashish; Marchetti, Elisa; Ariff, Shabina; Soofi, Sajid B; Anemona, Alessandra; Habib, Muhammad A; Alberto, Edison; Juvekar, Sanjay; Khan, Rana M Qasim; Marhaba, Rachid; Ali, Noshad; Malubay, Nelia; Kawade, Anand; Saul, Allan; Martin, Laura B; Podda, Audino

    2014-02-01

    Typhoid vaccination is a public health priority in developing countries where young children are greatly affected by typhoid fever. Because present vaccines are not recommended for children younger than 2 years, the Novartis Vaccines Institute for Global Health developed a conjugate vaccine (Vi-CRM197) for infant immunisation. We aimed to assess the immunogenicity and safety of Vi-CRM197 in participants of various ages in endemic countries in south and southeast Asia. We did two randomised, observer-blind, age de-escalation, phase 2 trials at two sites in Pakistan and India (study A), and at one site in the Philippines (study B), between March 2, 2011, and Aug 9, 2012. Adults aged 18-45 years, children aged 24-59 months, older infants aged 9-12 months, and infants aged 6-8 weeks were randomly assigned (1:1) with a computer-generated randomisation list (block size of four) to receive either 5 μg Vi-CRM197 or 25 μg Vi-polysaccharide vaccine (or 13-valent pneumococcal conjugate vaccine in children younger than 2 years). Both infant populations received Vi-CRM197 concomitantly with vaccines of the Expanded Programme on Immunization (EPI), according to WHO schedule. With the exception of designated study site personnel responsible for vaccine preparation, study investigators, those assessing outcomes, and data analysts were masked to treatment allocation. We specified no a-priori null hypothesis for the immunogenicity or safety objectives and all analyses were descriptive. Analyses were by modified intention-to-treat. These studies are registered with ClinicalTrials.gov, numbers NCT01229176 and NCT01437267. 320 participants were enrolled and vaccinated in the two trials: 200 in study A (all age groups) and 120 in study B (children and infants only), of whom 317 (99%) were included in the modified intention-to-treat analysis. One dose of Vi-CRM197 significantly increased concentrations of anti-Vi antibody in adults (from 113 U/mL [95% CI 67-190] to 208 U/mL [117

  19. Gene Therapy for Posttraumatic Osteoarthritis

    Science.gov (United States)

    2017-10-01

    using commercially available ELISA . Synovial fluids were diluted 1:1 with buffered saline containing hyaluronidase at 50 u/ml, and incubated at 37...collagen II (Chondrex, #6009) and PGE2 using commercially available ELISA . Estimated completion: October 2017. h) Major activity 8

  20. Heterologous expression of chaetomium thermophilum xylanase 11-a (ctx 11-a) gene

    International Nuclear Information System (INIS)

    Wajid, S.; Shahid, S.; Mukhtar, Z.; Mansoor, S.

    2009-01-01

    Chaetomium has a potential source of xylanase and cellulase enzymes, both of which are required in the treatment of fibre in the poultry feed. The titre of the enzymes needs to be enhanced by using recombinant DNA technology for fulfilling the requirement of the industries. Efforts are made to construct prokaryotic and eukaryotic expression cassettes that can be cloned under specific strong promoters i.e., T7 and AOX1, respectively, and the enhancer elements to get the maximum gene expression. In the present study BL21 E. coli and GS115 Pichia pastoris strains are used as model organisms to express the CtX 11-A gene in the presence of 1 mM IPTG and 100% methanol upto final concentration of 0.5. In case of BL21 expression, the maximum xylanase activity was observed after 1.5 h in the presence of 1% xylose, which was 2.302 U/ml and after 7 h in the presence of 0.5% lactose, was 1.708 U/ml. However, in Pichia pastoris the maximum production of xylanase was 2.904 and 0.006 U/ml as compared to control 0.484 and 0.06 U/ml, respectively. (author)

  1. Visualizing Metrics on Areas of Interest in Software Architecture Diagrams

    NARCIS (Netherlands)

    Byelas, Heorhiy; Telea, Alexandru; Eades, P; Ertl, T; Shen, HW

    2009-01-01

    We present a new method for the combined visualization of software architecture diagrams, Such as UML class diagrams or component diagrams, and software metrics defined on groups of diagram elements. Our method extends an existing rendering technique for the so-called areas of interest in system

  2. Reasoning about Use Cases using Logic Grammars and Constraints

    DEFF Research Database (Denmark)

    Christiansen, Henning; Have, Christian Theil; Tveitane, Knut

    2007-01-01

    We consider automated transition from Use Cases in a restricted natural language syntax into UML models, by trying to capture the semantics of the natural language and map it into building blocks of the object oriented programming paradigm. Syntax and semantic analysis is done in a framework...

  3. Ufo-element presentation in metamodel structure of triune continuum paradigm

    OpenAIRE

    Ukrayinets, ?.

    2006-01-01

    This paper describes results of UFO-element formal description in metamodel structure of Triune Continuum Paradigm. This can promote the solution of a problem of development of methods of mutual system-object UFO- and UML-models transformation for providing of more effective information systems designing, in particular, for visual modelling CASE-tools Rational Rose and UFO-Toolkit integration.

  4. Production of a biodegradable plastic-degrading enzyme from cheese whey by the phyllosphere yeast Pseudozyma antarctica GB-4(1)W.

    Science.gov (United States)

    Watanabe, Takashi; Shinozaki, Yukiko; Suzuki, Ken; Koitabashi, Motoo; Yoshida, Shigenobu; Sameshima-Yamashita, Yuka; Kuze Kitamoto, Hiroko

    2014-08-01

    Cheese whey is a by-product of cheese production and has high concentrations of lactose (about 5%) and other nutrients. Pseudozyma antarctica produces a unique cutinase-like enzyme, named PaE, that efficiently degrades biodegradable plastics. A previous study showed that a combination of 1% oil and 0.5% lactose increased cutinase-like enzyme production by another species of yeast. In this study, to produce PaE from cheese whey, we investigated the effects of soybean oil on PaE production (expressed as biodegradable plastic-degrading activity) by P. antarctica growing on lactose or cheese whey. In flask cultures, the final PaE activity was only 0.03 U/ml when soybean oil was used as the sole carbon source, but increased to 1.79 U/ml when a limited amount of soybean oil (under 0.5%) was combined with a relatively high concentration of lactose (6%). Using a 5-L jar fermentor with lactose fed-batch cultivation and periodic soybean oil addition, about 14.6 U/ml of PaE was obtained after 5 days of cultivation. When the lactose was replaced with cheese whey, PaE production was 10.8 U/ml after 3 days of cultivation. Copyright © 2014 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  5. Detection scheme for bioassays based on 2,6-pyridinedicarboxylic acid derivatives and enzyme-amplified lanthanide luminescence

    Energy Technology Data Exchange (ETDEWEB)

    Steinkamp, Tanja [Department of Chemical Analysis, MESA Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede (Netherlands); Karst, Uwe [Department of Chemical Analysis, MESA Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede (Netherlands)]. E-mail: u.karst@utwente.nl

    2004-11-15

    2,6-Pyridinedicarboxylic acid (PDC) and its derivatives are introduced as a new sensitizer system for enzyme-amplified lanthanide luminescence (EALL), a detection scheme for bioassays, which combines enzymatic amplification with time-resolved luminescence measurements of lanthanide chelates. Various PDC esters have been synthesized as esterase substrates that are cleaved to PDC in the presence of the enzyme. PDC forms luminescent complexes with Tb(III) or Eu(III), and the evaluation of the reaction is used for the selective and sensitive detection of esterases. For an esterase from hog liver a limit of detection of 10{sup -3} u/mL (equivalent to 10{sup -9} mol/L) and a limit of quantification of 3 x 10{sup -3} u/mL (equivalent to 3 x 10{sup -9} mol/L) could be achieved. As a second model reaction, xanthine oxidase (XOD) catalyzes the oxidation of 2,6-pyridinedicarboxaldehyde to PDC. Here, the limit of detection was 3 x 10{sup -3} u/mL and the limit of quantification 10{sup -2} u/mL for XOD from microorganisms. Major advantage of the tridentate PDC ligand is the possibility to perform all steps of the assay within or close to the physiological pH range, while the established EALL schemes based on bidentate salicylates or bisphenols have to be carried out at strongly alkaline pH to ensure sufficient complexation with the lanthanides.

  6. 1740-IJBCS-Article -Mohammed I. Jaaforu

    African Journals Online (AJOL)

    hp

    2Microbial Physiology and Biotechnology Research Group, Department of Botany and Microbiology, ... Trichoderma viride Fd18 produced 10.4 U/ml of xylanase using NH4Cl as nitrogen source, while NH4NO3 repressed enzyme production by Aspergillus ustus Fb2. The fungal ... characteristics according to Barnett (1960),.

  7. HANDOVER MANAGEABILITY AND PERFORMANCE MODELING IN

    African Journals Online (AJOL)

    SOFTLINKS DIGITAL

    Software is better modelled with the use of UML diagrams like use cases which ... analysis and design according to [1] is to transform the 'black .... The system request the user to enter his/her user_id .... The corresponding changes are saved.

  8. Extracts of Morinda oleifera (Moringaceae) show anti-retroviral ...

    African Journals Online (AJOL)

    Toshiba

    2013-07-24

    Jul 24, 2013 ... reported to act as cardiac and circulatory stimulants. (Duke, 2001; Nandave et al., 2009), have ... dried and ground to powder using a mechanical grinder. The methanol extract (MM) and petroleum ether ... (FBS), 100 U/ml penicillin and 100. µg/ml streptomycin. Tissue culture medium and supplements were.

  9. Approche complète de développement des IPs pour les SoCs A ...

    African Journals Online (AJOL)

    CoFluent and Quartus II tools have helped us to get the different models. ... Key words : IPs – SoC - Design and Reuse – UML – System C ... nouvelles techniques de conception doivent- .... obtenir un prototype fabriqué et testé. ..... Information Technology and Control, ... A new logic circuit design methodology with UMLl.

  10. Pedagogical Content Knowledge and Educational Cases in Computer Science: an Exploration

    NARCIS (Netherlands)

    Koppelman, Hermannus

    2008-01-01

    The concept of pedagogical content knowledge has been explored in the context of several disciplines, such as mathematics, medicine and chemistry. In this paper the concept is explored and applied to the subject matter of computer science, in particular to the sub domain of building UML class

  11. Nitrogen supplements effect on amylase production by Aspergillus ...

    African Journals Online (AJOL)

    The production of amylase by Aspergillus niger on three cassava whey media in liquid shake culture was compared. The supplemented cassava whey (SCW) medium exhibited gave amylase activity of 495 U/ml. Biomass cropped was 1.63 g/l in the SCW medium. Yeast extract employed as a nitrogen supplement increased ...

  12. Isolation and molecular characterization of phytase producing ...

    African Journals Online (AJOL)

    Isolation and molecular characterization of phytase producing bacteria from Malaysia hot springs. ... The strains were further analyzed in broth culture using sodium phytate as substrate. Among them, strain L3 was selected as the best producer (0.16 U/ml after 72 h of culture). This phytase showed optimal activity at 37 °C ...

  13. A Systematic Software, Firmware, and Hardware Codesign Methodology for Digital Signal Processing

    Science.gov (United States)

    2014-03-01

    Division B.S., Fu-Jen Catholic University , 1979 M.S.E.E, California State University , Northridge, 1992 Submitted in partial fulfillment of the...Table 74. External trigger characteristics ......................................................................129 Table 75. DDC IP core...size weight and power UAV unmanned aerial vehicle UHF ultra-high frequency UML universal modeling language Verilog verify logic VHDL VHSIC

  14. An Evaluation of ADLs on Modeling Patterns for Software Architecture

    NARCIS (Netherlands)

    Waqas Kamal, Ahmad; Avgeriou, Paris

    2007-01-01

    Architecture patterns provide solutions to recurring design problems at the architecture level. In order to model patterns during software architecture design, one may use a number of existing Architecture Description Languages (ADLs), including the UML, a generic language but also a de facto

  15. Study on the diagnostic value of determination of changes of serum CA125 and CA19-9 levels in patients with endometriosis

    International Nuclear Information System (INIS)

    Liu Aimin

    2008-01-01

    Objective: To explore the diagnostic value of determination of changes of serum CA125 and CA19-9 levels in patients with endometriosis. Methods: Serum CA125 and CA19-9 levels were determined with RIA in 45 patients with endometriosis and 40 controls. Results: Serum levels of CA125 and CA19-9 in patients with endometriosis (89.63 ± 30.16u/ml and 95.62±43.67u/ml respectively) were significantly higher than those (16.26±6.37u/ml and 20.26±8.25u/ml respectively) in controls (P<0. 001). Sensitivity of CA125 for diagnosis of endometriosis was 77.78% and that of CA19-9 was 62.22%, while the specificity was 92.50% and 90.00% respectively. If we only took the patients with both markers elevated as being diagnostically positive, the sensitivity would naturally be lower (57.78%) but the specificity would be 100%. Levels of the markers were significantly higher in stage III, IV patients than those in patients with stage I, II disease (P<0.01). Conclusion: Combined determination of serum CA125 and CA19-9 levels were of highly specific diagnostic value in patients with endometriosis. (authors)

  16. Production of alkaline proteases by alkalophilic Bacillus subtilis ...

    African Journals Online (AJOL)

    Among various nitrogen sources, yeast extract was found to be the best inducer of alkaline protease. Among metal salts, KNO3 and NH4Cl were found to increase protease production. The maximum enzyme production (3600 U/ml) was observed with pomegranate peels of fermentation medium in the presence of yeast ...

  17. Conversion of Squid Pens to Chitosanases and Proteases via Paenibacillus sp. TKU042

    Directory of Open Access Journals (Sweden)

    Chien Thang Doan

    2018-03-01

    Full Text Available Chitosanases and proteases have received much attention due to their wide range of applications. Four kinds of chitinous materials, squid pens, shrimp heads, demineralized shrimp shells and demineralized crab shells, were used as the sole carbon and nitrogen (C/N source to produce chitosanases, proteases and α-glucosidase inhibitors (αGI by four different strains of Paenibacillus. Chitosanase productivity was highest in the culture supernatants using squid pens as the sole C/N source. The maximum chitosanase activity of fermented squid pens (0.759 U/mL was compared to that of fermented shrimp heads (0.397 U/mL, demineralized shrimp shells (0.201 U/mL and demineralized crab shells (0.216 U/mL. A squid pen concentration of 0.5% was suitable for chitosanase, protease and αGI production via Paenibacillus sp. TKU042. Multi-purification, including ethanol precipitation and column chromatography of Macro-Prep High S as well as Macro-Prep DEAE (diethylaminoethyl, led to the isolation of Paenibacillus sp. TKU042 chitosanase and protease with molecular weights of 70 and 35 kDa, respectively. For comparison, 16 chitinolytic bacteria, including strains of Paenibacillus, were investigated for the production of chitinase, exochitinase, chitosanase, protease and αGI using two kinds of chitinous sources.

  18. Extensions of Statecharts with probability, time, and stochastic timing

    NARCIS (Netherlands)

    Jansen, D.N.

    2003-01-01

    Statecharts are a graphical language to describe the behaviour of a (computer) system. Statecharts are, among others, used as a part of the UML (Unified Modelling Language). This thesis describes three extensions related to statecharts. One of them is a real-time property language that fits well

  19. A 100 GHz Polarimetric Compact Radar Range for Scale-Model Radar Cross Section Measurements

    Science.gov (United States)

    2013-10-01

    common radar bands. ACKNOWLEDGEMENTS The authors wish to thank David Jillson (UML STL – Electrical Engineer) for efforts involved in RF and DC wiring...Waldman J., Fetterman H.R., Duffy P.E., Bryant T.G., Tannenwald P.E., “Submillimeter Model Measurements and Their Applications to Millimeter Radar

  20. Early postnatal exposure to lithium in vitro induces changes in ...

    Indian Academy of Sciences (India)

    2015-04-27

    Apr 27, 2015 ... P0-P2 day old Wistar rat pups were treated with papain solution (20 U/mL enzyme ...... recycling routes selectively fill two vesicle pools in frog motor nerve terminals. ... inhibits protein kinase C translocation in rat brain cortex.

  1. Querying Business Process Models with VMQL

    DEFF Research Database (Denmark)

    Störrle, Harald; Acretoaie, Vlad

    2013-01-01

    The Visual Model Query Language (VMQL) has been invented with the objectives (1) to make it easier for modelers to query models effectively, and (2) to be universally applicable to all modeling languages. In previous work, we have applied VMQL to UML, and validated the first of these two claims. ...

  2. Mining Software Repositories with CVSgrab

    NARCIS (Netherlands)

    Voinea, Lucian; Telea, Alexandru

    2006-01-01

    In this paper we address the process and team analysis categories of the MSR Mining Challenge 2006. We use our CVSgrab tool to acquire the data and interactively visualize the evolution of ArgoUML and PostgreSQL, in order to answer three relevant questions. We conclude summarizing the strong and

  3. Mining software repositories with CVSgrab

    NARCIS (Netherlands)

    Telea, A.C.; Voinea, S.L.

    2006-01-01

    In this paper we address the process and team analysis categories of the MSR Mining Challenge 2006. We use our CVSgrab tool to acquire the data and interactively visualize the evolution of ArgoUML and PostgreSQL, in order to answer three relevant questions. We conclude summarizing the strong and

  4. Evaluation of a new Syphilis assay on Vitros® 5600 Integrated System

    Directory of Open Access Journals (Sweden)

    Giusy Longo

    2010-12-01

    Full Text Available Introduction. A new homogeneous immunoassay for detection of primary infection of Treponema Pallidum (TP on Vitros® 5600 Integrated System was evaluated.The scope of the study was to verify analytical performances and diagnostic accuracy in comparison to commercial methods (Immunoblotting test, ELISA test, Immunoturbidimetric test. Methods. The new Syphilis assay from SENTINEL CH. SpA, is an immunoturbidimetric assay, using microparticles coated with TP fixed on the surface of polystyrene latex particles which agglutinate by an antigen-antibody reaction when anti-TP antigen is present in the specimen. The assay was implemented on Vitros® 5600 Integrated System. Modified CLSI protocols were adopted. Acceptance criteria for total imprecision were 5% for negative samples (or SD 0.5 U/mL and 4% for positive samples. In comparison to commercial methods, sensitivity must be 99.5% and specificity 99.5%. Results. Total imprecision (22 days gave SD at 6 U/mL lower than 0.5 U/mL, and CV% at 10 U/mL and 45 U/mL lower than 4%. Low quantitation limit is 5 U/mL. No prozone up to 13000 U/mL was found. In the on-board calibration stability study no drift was found up to 4 weeks. 153 samples were tested vs immunoblotting method and specificity was 100%, sensitivity was 100%. 495 samples were tested vs ELISA method and test specificity and sensitivity were 99.6% and 100% respectively. 521 samples were tested vs immunoturbidimetric method and specificity was 99.8%, sensitivity was 100%. Interference from Bilirubin (20 mg/dL, Hemoglobin (500 mg/dL and Triglycerides (1000 mg/dL was not detected.All the sample collection tubes tested (K2EDTA, SST, LH PST II, LH, NH did not interfere with the assay. Conclusion. Performances of the new SENTINEL Syphilis assay on Vitros® 5600 Integrated System meet the requirements for its use as screening tool in blood bank, thus allowing consolidation with general chemistry on a single high volume chemistry analyzer, which is

  5. Association of Anti-glycan Antibodies and Inflammatory Bowel Disease Course.

    Science.gov (United States)

    Paul, S; Boschetti, G; Rinaudo-Gaujous, M; Moreau, A; Del Tedesco, E; Bonneau, J; Presles, E; Mounsef, F; Clavel, L; Genin, C; Flourié, B; Phelip, J-M; Nancey, S; Roblin, X

    2015-06-01

    The usefulness of anti-glycan antibodies alone or combined with anti-Saccharomyces cerevisiae [ASCA] or perinuclear antineutrophil cytoplasmic [pANCA] antibodies for diagnosis of inflammatory bowel disease [IBD], differentiation between Crohn's disease [CD] and ulcerative colitis [UC], disease stratification including IBD phenotype, and also for determination of the course of the disease, remain unclear. A large panel of serological anti-glycan carbohydrate antibodies, including anti-mannobioside IgG antibodies [AMCA], anti-chitobioside IgA [ACCA], anti-laminaribioside IgG antibodies [ALCA], anti-laminarin [anti-L] and anti-chitine [anti-C] were measured in the serum from a cohort of 195 patients with IBD] [107 CD and 88 UC]. The respective accuracy of isolated or combined markers for diagnosis, disease differentiation, stratification disease phenotype, and severity of the disease course, defined by a wide panel of criteria obtained from the past medical history, was assessed. The positivity of at least one anti-glycan antibody was detected in a significant higher proportion of CD and UC compared with healthy controls [p ACCA [> 51U/ml] and anti-laminarin [> 31U/ml] were significantly linked with a higher association with steroid dependency (odds ratio [OR] =2.0 [1.0-4.0], p = 0.03 and OR = 2.4 [1.1-5.2], p = 0.02, respectively]. We further defined the respective performance of anti-glycan antibodies to discriminate between patients with severe or not severe CD and UC course and determined the associated optimal cut-off values: severe CD course was significantly more likely in case of AMCA > 77U/ml [OR = 4.3; p = 0.002], ASCA > 63U/ml [OR = 3.5; p ACCA > 50U/ml [OR = 2.8; p 52U/ml [OR = 3.4; p = 0.04] and ACCA > 25U/ml [OR = 3.0; p < 0.04]. Anti-glycan antibodies are valuable serological markers, especially AMCA antibodies that may help clinicians to promptly classify patients into high risk for severe disease. Copyright © 2015 European Crohn’s and Colitis

  6. Plasma levels of soluble CD30 in kidney graft recipients as predictors of acute allograft rejection.

    Science.gov (United States)

    Ayed, K; Abdallah, T B; Bardi, R; Abderrahim, E; Kheder, A

    2006-09-01

    In renal transplant recipients elevated soluble serum CD30 levels are associated with increased rejection and graft loss. We sought to determine the sCD30 plasma levels before and after kidney transplantation and to assess whether sCD30 was a predictive factor of immunological risk. sCD30 plasma levels were determined by an enzyme-linked immunosorbent assay assay in 52 kidney graft recipients before as well as 7, 15, and 21 days after transplantation. Eighteen patients developed acute allograft rejection (group I) and 34 patients showed uneventful courses (group II). Before transplantation sCD30 plasma levels were elevated in both groups (mean: 162.6 +/- 89.5 U/mL). After transplantation, group I recipients with acute rejection showed higher relative levels of plasma sCD30 on days 7 and 15 (120.8 +/- 74.6 U/mL and 210.6 +/- 108.7 U/mL respectively) compared with group II patients without rejection (95 +/- 45 U/mL and 59.4 +/- 31.6 U/mL), a difference that was significant for group I (P = .0003) and not significant for group II (P = .09). On day 21, sCD30 decreased in the two groups but remained higher among group I patients (120.6 +/- 92.7 U/mL). HLA antibodies were positive in 18 patients (34.6%) with 9 (50%) experiencing at last one episode of acute rejection. Among 34 patients negative for anti-HLA antibodies, nine displayed acute rejection only (26.4%), a difference that was not significant (P > .05). If we consider 100 U/mL as the minimum predictive level for allograft rejection, our results suggested that levels of sCD30 should be taken into consideration with the presence of HLA-antibodies detectable before and after transplantation, especially in patients with more than three HLA mismatches [RR = 3.20 (0.94 sCD30 is a useful procedure for the recognition of rejection in its earliest stages.

  7. Soluble CD30 in patients with antibody-mediated rejection of the kidney allograft.

    Science.gov (United States)

    Slavcev, Antonij; Honsova, Eva; Lodererova, Alena; Pavlova, Yelena; Sajdlova, Helena; Vitko, Stefan; Skibova, Jelena; Striz, Ilja; Viklicky, Ondrej

    2007-07-01

    The aim of our retrospective study was to evaluate the clinical significance of measurement of the soluble CD30 (sCD30) molecule for the prediction of antibody-mediated (humoral) rejection (HR). Sixty-two kidney transplant recipients (thirty-one C4d-positive and thirty-one C4d-negative patients) were included into the study. Soluble CD30 levels were evaluated before transplantation and during periods of graft function deterioration. The median concentrations of the sCD30 molecule were identical in C4d-positive and C4d-negative patients before and after transplantation (65.5 vs. 65.0 and 28.2 vs. 36.0 U/ml, respectively). C4d+ patients who developed DSA de novo had a tendency to have higher sCD30 levels before transplantation (80.7+/-53.6 U/ml, n=8) compared with C4d-negative patients (65.0+/-33.4 U/ml, n=15). Soluble CD30 levels were evaluated as positive and negative (>or=100 U/ml and sCD30 estimation with regard to finding C4d deposits in peritubular capillaries were determined. The sensitivity of sCD30+ testing was generally below 40%, while the specificity of the test, i.e. the likelihood that if sCD30 testing is negative, C4d deposits would be absent, was 82%. C4d+ patients who developed DSA de novo were evaluated separately; the specificity of sCD30 testing for the incidence of HR in this cohort was 86%. We could not confirm in our study that high sCD30 levels (>or=100 U/ml) might be predictive for the incidence of HR. Negative sCD30 values might be however helpful for identifying patients with a low risk for development of DSA and antibody-mediated rejection.

  8. Soluble CD30 levels in recipients undergoing heart transplantation do not predict post-transplant outcome.

    Science.gov (United States)

    Ypsilantis, Efthymios; Key, Timothy; Bradley, J Andrew; Morgan, C Helen; Tsui, Stephen; Parameshwar, Jayan; Taylor, Craig J

    2009-11-01

    The pre-transplant serum level of soluble CD30 (sCD30), a proteolytic derivative of the lymphocyte surface receptor CD30, has been suggested as a biomarker for immunologic risk after organ transplantation. Pre-transplant serum sCD30 levels were determined in 200 consecutive adult heart transplant recipients undertaken at a single center. Transplant outcome (acute rejection in the first 12 months and patient survival up to 5 years post-transplant) was determined. Patients treated with a left ventricular assist device (LVAD) prior to transplantation (n = 28) had higher levels of sCD30 (median 64 U/ml, range 12 to 112 U/ml) than those (n = 172) with no LVAD (median 36 U/ml, range 1 to 158 U/ml, p sCD30 levels were "low" (lower quartile, 58 U/ml, n = 50). Neither acute rejection nor recipient survival differed according to sCD30 level, with values (mean +/- SEM) of 0.30 +/- 0.04, 0.23 +/- 0.03 and 0.30 +/- 0.05 acute rejection episodes per 100 days in the low, intermediate and high groups, respectively, with recipient survival rates at 1 year of 77.7%, 84.9% and 86% and at 5 years of 73.6%, 67.9% and 75.8%, respectively. Pre-transplant serum sCD30 level does not predict acute allograft rejection or recipient survival after heart transplantation, although sCD30 levels are increased by LVAD, possibly as a result of biomaterial-host immune interaction.

  9. Enzymatic comparison and mortality of Beauveria bassiana against cabbage caterpillar Pieris brassicae LINN.

    Science.gov (United States)

    Dhawan, Manish; Joshi, Neelam

    Beauveria bassiana, an entomopathogenic fungus, is the alternative biocontrol agent exploited against major economic crop pests. Pieris brassicae L. is an emerging pest of the Brassicaceae family. Therefore, in the present study, fungal isolates of Beauveria bassiana, viz. MTCC 2028, MTCC 4495, MTCC 6291, and NBAII-11, were evaluated for their virulence against third instar larvae of P. brassicae. Among all these fungal isolates, maximum mortality (86.66%) was recorded in B. bassiana MTCC 4495 at higher concentration of spores (10 9 conidia/ml), and the minimum mortality (30.00%) was recorded in B. bassiana MTCC 6291 at a lower concentration (10 7 conidia/ml) after ten days of treatment. The extracellular cuticle-degrading enzyme activities of fungal isolates were measured. Variability was observed both in the pattern of enzyme secretion and the level of enzyme activities among various fungal isolates. B. bassiana MTCC 4495 recorded the maximum mean chitinase (0.51U/ml), protease (1.12U/ml), and lipase activities (1.36U/ml). The minimum mean chitinase and protease activities (0.37 and 0.91U/ml, respectively) were recorded in B. bassiana MTCC 6291. The minimum mean lipase activity (1.04U/ml) was recorded in B. bassiana NBAII-11. Our studies revealed B. bassiana MTCC 4495 as the most pathogenic isolate against P. brassicae, which also recorded maximum extracellular enzyme activities, suggesting the possible roles of extracellular enzymes in the pathogenicity of B. bassiana against P. brassicae. Copyright © 2017 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda. All rights reserved.

  10. Evaluation of emergency medical text processor, a system for cleaning chief complaint text data.

    Science.gov (United States)

    Travers, Debbie A; Haas, Stephanie W

    2004-11-01

    Emergency Medical Text Processor (EMT-P) version 1, a natural language processing system that cleans emergency department text (e.g., chst pn, chest pai), was developed to maximize extraction of standard terms (e.g., chest pain). The authors compared the number of standard terms extracted from raw chief complaint (CC) data with that for CC data cleaned with EMT-P and evaluated the accuracy of EMT-P. This cross-sectional observation study included CC text entries for all emergency department visits to three tertiary care centers in 2001. Terms were extracted from CC entries before and after cleaning with EMT-P. Descriptive statistics included number and percentage of all entries (tokens) and all unique entries (types) that matched a standard term from the Unified Medical Language System (UMLS). An expert panel rated the accuracy of the CC-UMLS term matches; inter-rater reliability was measured with kappa. The authors collected 203,509 CC entry tokens, of which 63,946 were unique entry types. For the raw data, 89,337 tokens (44%) and 5,081 types (8%) matched a standard term. After EMT-P cleaning, 168,050 tokens (83%) and 44,430 types (69%) matched a standard term. The expert panel reached consensus on 201 of the 222 CC-UMLS term matches reviewed (kappa=0.69-0.72). Ninety-six percent of the 201 matches were rated equivalent or related. Thirty-eight percent of the nonmatches were found to match UMLS concepts. EMT-P version 1 is relatively accurate, and cleaning with EMT-P improved the CC-UMLS term match rate over raw data. The authors identified areas for improvement in future EMT-P versions and issues to be resolved in developing a standard CC terminology.

  11. COHeRE: Cross-Ontology Hierarchical Relation Examination for Ontology Quality Assurance.

    Science.gov (United States)

    Cui, Licong

    Biomedical ontologies play a vital role in healthcare information management, data integration, and decision support. Ontology quality assurance (OQA) is an indispensable part of the ontology engineering cycle. Most existing OQA methods are based on the knowledge provided within the targeted ontology. This paper proposes a novel cross-ontology analysis method, Cross-Ontology Hierarchical Relation Examination (COHeRE), to detect inconsistencies and possible errors in hierarchical relations across multiple ontologies. COHeRE leverages the Unified Medical Language System (UMLS) knowledge source and the MapReduce cloud computing technique for systematic, large-scale ontology quality assurance work. COHeRE consists of three main steps with the UMLS concepts and relations as the input. First, the relations claimed in source vocabularies are filtered and aggregated for each pair of concepts. Second, inconsistent relations are detected if a concept pair is related by different types of relations in different source vocabularies. Finally, the uncovered inconsistent relations are voted according to their number of occurrences across different source vocabularies. The voting result together with the inconsistent relations serve as the output of COHeRE for possible ontological change. The highest votes provide initial suggestion on how such inconsistencies might be fixed. In UMLS, 138,987 concept pairs were found to have inconsistent relationships across multiple source vocabularies. 40 inconsistent concept pairs involving hierarchical relationships were randomly selected and manually reviewed by a human expert. 95.8% of the inconsistent relations involved in these concept pairs indeed exist in their source vocabularies rather than being introduced by mistake in the UMLS integration process. 73.7% of the concept pairs with suggested relationship were agreed by the human expert. The effectiveness of COHeRE indicates that UMLS provides a promising environment to enhance

  12. Aliesterase no sôro de alguns animais de laboratório Blood aliesterase in some laboratory animals

    Directory of Open Access Journals (Sweden)

    Maria Isabel Mello

    1949-12-01

    Full Text Available A esterase, aliesterase, foi determinada no sôro de 38 ratos de ambos os sexos, 6 hamsters, 34 cobaias e S coelhos, pela técnica de Huggins e Lapides. Os resultados obtidos para os machos e fêmeas foram tabelados em separado. As fêmeas apresentaram uma esterasemia maior que os machos, com uma média global de 11.6 U/ml ± 4.01 e um erro padrão de 0.83 enquanto que para os machos a média foi de 6.9 U ml ± 0.99 com um erro padrão de 0.26. A significância calculada pclo t foi de 4.4 Isto demonstra a interferência da aliesterase na produção ou no metabolismo dos estrogênios. Os valores médios encontrados para as cobaias foram 4.50 U/ ml ± 0.15, com um êrro padrão de 0.036 para as fêmeas e 4.28 U / ml ± 0.30 com um êrro padrão de 0.073 para os machos, sendo a significância (t de 2.6. Para os coelhos (machos a média foi de 4.41 U / ml ± 0.16, com um erro padrão de 0.058 enquanto para os hamsters os valores foram de 4.01 U/l ± 0.085, êrro padrão de 0.049 para os machos e 3.81 U/ml ± 0.227, êrro padrão de 0.133 para as fêmeas. Os animais castrados mostram uma diminuição progressiva da esterase no sôro, enquanto que nos castrados e tratados com estrogênios, êstes valores atingem o teôr normal. Os resultados obtidos nestes casos serão objeto de publicação ulterior.Esterase, "aliesterase" was determined, in blood sera from 38 rats, 6 hamsters, 34 guinea-pig and 8 rabbits by the Huggins & Lapides' method. Normal values for male and female animals were related separately. In female rat, blood aliesterase is higher within a mean value of 11.6 U/ml ± 4.01 and standard error of 0.83. Aliesterase sera values in male are lower than in female. The mean value being 6.9 U/ml ± 0.99, standard error, 0.26. The significance of means (t for female and male rats was 4.4. This fact reveals that aliesterase concentration in sera is related with estrogen production or metabolism. For guinea-pig the mean values were 4.50 U/ml ± 0

  13. Examining the interrelationships among students' personological characteristics, attitudes toward the Unified Modeling Language, self-efficacy, and multiple intelligences with respect to student achievement in a software design methods course

    Science.gov (United States)

    Stewart-Iles, Gail Marie

    The purpose of this study was to investigate the interrelationships among student's demographics, attitudes toward the Unified Modeling Language (UML), general self-efficacy, and multiple intelligence (MI) profiles, and the use of UML to develop software. The dependent measures were course grades and course project scores. The study was grounded in problem solving theory, self-efficacy theory, and multiple intelligence theory. The sample was an intact class of 18 students who took the junior-level Software Design Methods course, CSE 3421, at Florida Institute of Technology in the Spring 2008 semester. The course incorporated instruction in UML with Java. Attitudes were measured by a researcher-modified instrument derived from the Computer Laboratory Survey by Newby and Fisher, and self-efficacy was measured by the Generalized Self-Efficacy Scale developed by Schwarzer and Jerusalem. MI profiles, which were the proportion of Gardner's eight intelligences, were determined from Shearer's Multiple Intelligence Developmental Assessment Scales. Results from a hierarchical multiple regression analysis showed that only the collective set of MI profiles was significant, but none of the individual intelligences were significant. The study's findings supported what one would expect to find relative to problem solving theory, but were contradictory to self-efficacy theory. The findings also supported Gardner's concept that multiple intelligences must be considered as an integral unit and the importance of not focusing on an individual intelligence. The findings imply that self-efficacy is not a major consideration for a software design methods class that requires a transition to problem solving strategy and suggest that the instructor was instrumental in fostering positive attitudes toward UML. Recommendations for practice include (1) teachers should not be concerned with focusing on a single intelligence simply because they believe one intelligence might be more aligned to a

  14. Immunological monitoring after organ transplantation: potential role of soluble CD30 blood level measurement.

    Science.gov (United States)

    Truong, Dinh Quang; Darwish, Ahmed A; Gras, Jérémie; Wieërs, Grégoire; Cornet, Anne; Robert, Annie; Mourad, Michel; Malaise, Jacques; de Ville de Goyet, Jean; Reding, Raymond; Latinne, Dominique

    2007-06-01

    Analysing the relevance of soluble CD30 (sCD30) in the bloodstream before and after transplantation may be important for the monitoring of transplant recipients. In this study, 27 patients (15 pediatric liver and 12 adult kidney graft recipients) were investigated. In the liver graft group, the patients who developed acute rejection during the first month (n=9) had a slightly higher sCD30 value on pre-transplantation baseline (day 0) and post-transplantation day 7, when compared to patients with normal graft function (n=6) (day 0: 102(1.6) U/ml versus 118(1.5) U/ml, p=0.52) and (day 7: 69(1.5) U/ml versus 83(1.6) U/ml, p=0.47). Increased serum sCD30 was shown to correlate with increased interleukin-10 circulating levels between day 0 and day 7 (r=0.53; p=0.04), whereas, no correlation could be evidenced between interferon-gamma (IFN-gamma) and sCD30 (r=0.02; p=0.47). Similarly, in the kidney transplantation group, no significant difference was found in sCD30 levels at day 0 in both groups with graft rejection or normal graft function (n=6) (85(1.3) U/ml versus 77(1.6) U/ml, p=0.66), but sCD30 decreased significantly at day 7 post-transplantation from baseline value in the rejection group (n=6) (77(1.6) versus 35(1.4); p=0.02). We conclude that increased serum sCD30 was correlated with increased IL-10 (interleukin-10) circulating levels, but not with IFN-gamma levels in the post-transplantation period. Neither pre-transplantation sCD30 nor sCD30 at day 7 post-transplantation could be correlated with acute rejection in liver graft recipient. The monitoring of sCD30 might constitute a tool to assess the risk of acute rejection in renal transplant but did not appear as a valuable mean for early immunological monitoring in the small group of liver allograft recipients patients analysed in this study.

  15. Pedunculated uterine leiomyoma associated with pseudo-Meigs' syndrome and elevated CA-125 level: CT features

    International Nuclear Information System (INIS)

    Kebapci, Mahmut; Aslan, Ozgur; Kaya, Tamer; Yalcin, Omer T.; Ozalp, Sinan

    2002-01-01

    A 38-year-old woman presented with a 1-week history of low back pain, distension, weakness, and loss of appetite. Laboratory studies showed a serum CA-125 level of 281 U/ml (normal value 1.2-32 U/ml). Abdominopelvic sonography revealed massive ascites, left pleural effusion, and a heterogeneous, hypoechogenic, and smoothly outlined solid mass. The mass had a close proximity and to the anterior side of the right ovary. Doppler sonography showed that the mass was hypervascularized. Computed tomography demonstrated numerous, tortuous vascular structures around the mass and along the omentum indicating its auxiliary vascularization from the omentum. Exploratory laparotomy and histopathological examination revealed pedunculated leiomyoma with parasitized blood supply from the omentum. Ascites and pleural effusion disappeared 6 months after surgery. We present the clinical and CT features of a parasitic leiomyoma adhering to the omentum. (orig.)

  16. AKTIVITAS PROTEOLITIK BAKTERI ASAM LAKTAT DALAM FERMENTASI SUSU KEDELAI [Proteolytic Activities of Lactic Acid Bacteria in Fermentation of Soymilk

    Directory of Open Access Journals (Sweden)

    Yusmarini1,2*

    2010-12-01

    Full Text Available Some lactic acid bacteria (LAB strains had been isolated from spontaneously fermented soymilk which have proteolytic system. The purpose of this research was to study ability of isolates in fermentation of soymilk. The changes in bacterial growth, pH, titrable acidity, and proteolytic activities during fermentation were examined. Isolates of Lactobacillus plantarum 1 R.1.3.2; L. plantarum 1 R.11.1.2 and L. acidophilus FNCC 0051 (as a control were capable growing in soymilk. The results indicated that initial pH of soymilk was 6,6 and decreased to 4,6 after fermentation and titrable acidity of 0.11 increased to 0.34 after fermentation. The proteolytic activities were 0.352 U/ml – 0.468 U/ml. The electrophoretic pattern of the proteins showed changes during fermentation of soymilk.

  17. An approach for activity-based DEVS model specification

    DEFF Research Database (Denmark)

    Alshareef, Abdurrahman; Sarjoughian, Hessam S.; Zarrin, Bahram

    2016-01-01

    Creation of DEVS models has been advanced through Model Driven Architecture and its frameworks. The overarching role of the frameworks has been to help develop model specifications in a disciplined fashion. Frameworks can provide intermediary layers between the higher level mathematical models...... and their corresponding software specifications from both structural and behavioral aspects. Unlike structural modeling, developing models to specify behavior of systems is known to be harder and more complex, particularly when operations with non-trivial control schemes are required. In this paper, we propose specifying...... activity-based behavior modeling of parallel DEVS atomic models. We consider UML activities and actions as fundamental units of behavior modeling, especially in the presence of recent advances in the UML 2.5 specifications. We describe in detail how to approach activity modeling with a set of elemental...

  18. IMPROVEMENT OF THE F-PERCEPTORY APPROACH THROUGH MANAGEMENT OF FUZZY COMPLEX GEOGRAPHIC OBJECTS

    Directory of Open Access Journals (Sweden)

    B. Khalfi

    2015-08-01

    Full Text Available In the real world, data is imperfect and in various ways such as imprecision, vagueness, uncertainty, ambiguity and inconsistency. For geographic data, the fuzzy aspect is mainly manifested in time, space and the function of objects and is due to a lack of precision. Therefore, the researchers in the domain emphasize the importance of modeling data structures in GIS but also their lack of adaptation to fuzzy data. The F-Perceptory approachh manages the modeling of imperfect geographic information with UML. This management is essential to maintain faithfulness to reality and to better guide the user in his decision-making. However, this approach does not manage fuzzy complex geographic objects. The latter presents a multiple object with similar or different geographic shapes. So, in this paper, we propose to improve the F-Perceptory approach by proposing to handle fuzzy complex geographic objects modeling. In a second step, we propose its transformation to the UML modeling.

  19. DETERMINATION of OPTIMUM CONDITION of PAPAIN ENZYME FROM PAPAYA VAR JAVA (Carica papaya

    Directory of Open Access Journals (Sweden)

    Aline Puspita Kusumadjaja

    2010-06-01

    Full Text Available A study to investigate the optimum condition of papain enzyme has been carried out. The condition that are investigated are pH and temperature, based on measurement of enzyme activity which is defined as mmole tyrosin that are released in reaction between papain enzyme and casein as substrat per minute. In this research, the papain enzyme was isolated from pepaya burung varietas Java. The enzyme was partially purified by precipitation method using 30% - 50% saturated acetone. The result showed that the optimum conditions of papain enzyme are in pH 6 with activity 2,606 U/mL, and temperature at 50 oC with activity 2,469 U/mL. Keywords : Papaya var Java, papain, optimum condition, enzymatic activity

  20. The comparison of the measurement of human serum thyroid globulin auto-antibodies and thyroid peroxidase auto-antibodies by CLIA and RIA

    International Nuclear Information System (INIS)

    Song Ailing; Guo Zhisheng; Sun Meili; Lian Xiaolan; Bai Yao

    2003-01-01

    The serum levels of thyroid globulin auto-antibodies (Anti-TgAb) and thyroid peroxidase auto-antibodies (Anti-TpoAb) in 37 patients with hyperthyroidism, 30 with chronic lymphocytic thyroidism, 36 with other endocrine diseases and 35 healthy persons were determined by chemiluminescence immunoassay (CLIA) and RIA, and the results were compared with each other. The results showed: (1) The within-batch CVs of CLIA and RIA were 3.0% and 10.0%, and the between-batch CVs were 3.9% and 15.0%, respectively; (2) The levels of serum anti-TgAb and Anti-TpoAb in healthy people were 25.9±9.6 U/mL and 31.4±6.7U/mL by CLIA, while those were 11.2±2.8% and 8.7±3.0% by RIA; (3) The levels of serum anti-TgAb and Anti-TpoAb of chronic lymphocytic thyroidism were 292.6±334.1U/mL and 5043.3±3196.1U/mL (n=17) by CLIA, while those were 56.4±11.2% (n=21) and 35.4±6.9% (n=21) by RIA. It showed that levels of anti-TgAb and Anti-TpoAb of chronic lymphocytic thyroidism were much higher than that in healthy people by CLIA (P<0.001). Furthermore, the levels of Anti-TpoAb were more than 100 times of that in health people by CLIA and the specificity of Anti-TpoAb was higher; (4) The levels of anti-TgAb and Anti-TpoAb in hyperthyroid patients were 202.3±506.3U/mL and 452.9±645.8U/mL by CLIA, while those were 28.8±20.0% and 22.6±14.2% by RIA. The levels of Anti-TgAb and Anti-TpoAb in patients with other endocrine disease were 28.7±15.0U/mL and 58.8±45.7U/mL by CLIA, while those were 10.2±13.3% and 7.9±7.7% by RIA; (5) These is a significant correlation between the two methods: Anti TgAb r=0.695; and Anti-TpoAb r=0.489. This results show that it may be more sensitive and specific test of Anti-TpoAb with CLIA than with RIA. CLIA should be used as a powerful diagnostic tool in clinical because it is simple, quick and without radioisotope

  1. Direct long-term effects of L-asparaginase on rat and human pancreatic islets

    DEFF Research Database (Denmark)

    Clausen, Niels; Nielsen, Jens Høiriis

    1989-01-01

    L-Asparaginase, an effective agent in the treatment of acute lymphoblastic leukemia, may induce a diabetic state. The pathogenesis of the diabetogenic effect was studied in cultured pancreatic islets. Mean serum concentrations in three children with acute lymphoblastic leukemia were 2.4 U/mL (range...... the glucagon content was unchanged. Removal of the drug resulted in partial recovery of the insulin secretion. To elucidate the mechanisms of of action of the drug, insulin biosynthesis was studied in islets cultured in asparagine-free medium with or without asparaginase. No difference in biosynthesis was seen...... between media with or without asparagine, whereas 0.1 U/mL asparaginase caused about a 50% reduction under both conditions.(ABSTRACT TRUNCATED AT 250 WORDS)...

  2. Alkaline protease production from industrial wastes by bacillus subtilis ML-4

    International Nuclear Information System (INIS)

    Sher, M.G.; Nadeem, M.; Syed, Q.; Irfan, M.; Baig, S.

    2010-01-01

    The influence of various culture conditions on protease production by Bacillus subtilis ML-4 was studied in the presence of growth medium containing poultry feed waste (5%), K/sub 2/HPO/sub 4/ (0.3%), CaCl/sub 2/ (0.03%) and MgSO/sub 4/ (0.015%). Maximum protease production (264.25 +- 1.86 U/ml) was observed at initial pH 9 with 3% (v/v) of inoculum size after 48 h of incubation at 37 degree C. The alkaline protease was stable over a broad range of temperature (30 to 60 degree C) and pH (8 to 11). However, maximum activity (155.45 U/ml) was observed at temperature 50 degree C and pH 10. (author)

  3. Building a genome database using an object-oriented approach.

    Science.gov (United States)

    Barbasiewicz, Anna; Liu, Lin; Lang, B Franz; Burger, Gertraud

    2002-01-01

    GOBASE is a relational database that integrates data associated with mitochondria and chloroplasts. The most important data in GOBASE, i. e., molecular sequences and taxonomic information, are obtained from the public sequence data repository at the National Center for Biotechnology Information (NCBI), and are validated by our experts. Maintaining a curated genomic database comes with a towering labor cost, due to the shear volume of available genomic sequences and the plethora of annotation errors and omissions in records retrieved from public repositories. Here we describe our approach to increase automation of the database population process, thereby reducing manual intervention. As a first step, we used Unified Modeling Language (UML) to construct a list of potential errors. Each case was evaluated independently, and an expert solution was devised, and represented as a diagram. Subsequently, the UML diagrams were used as templates for writing object-oriented automation programs in the Java programming language.

  4. Aktivitas Protease Dari Bacillus circulans Pada Media Pertumbuhan Dengan pH Tidak Terkontrol

    Directory of Open Access Journals (Sweden)

    La Ode Sumarlin

    2017-03-01

    Full Text Available Salah satu enzim yang telah banyak dipelajari adalah enzim protease. Jenis enzim inimerupakan enzim yang penting dari segi ekonomi karena menguasai 59% dari total penjualanenzim di dunia. Aplikasi protese telah meluas, baik pada industri pangan maupun nonpangan.Industri pangan memanfaatkan protease untuk memperbaiki tekstur, mempersingkat waktupencampuran, dan meningkatkan volume adonan pada pembuatan roti, menjernihkan bir,mengempukkan daging, dan menggumpalkan susu. Enzim ini dapat dproduksi oleh mikrobadalam suatu media mengandung Air Rendaman Kedelai (ARK dengan pH tidak terkontrol.Pengukuran aktivitas enzim menggunakan metode Bergmeyer dan Grassl sedangkan kadarprotein ditentukan dengan metode Bradford. Hasil analisis menunjukkan bahwa AktivitasProtease (AP pada media Air Rendaman Kedelai dan media standar dengan pH tidakterkontrol masing-masing sebesar 0,1814 U/ml dan 0,0342 U/ml. Produksi protease pada mediatersebut optimum pada pH 9,28, jam ke-56 pada fase akhir eksponensial dari fase pertumbuhanmikroba.

  5. Phenol oxidation of petrol refinery wastewater catalyzed by Laccase

    International Nuclear Information System (INIS)

    Vargas, Maria Carolina; Ramirez, Nubia E.

    2002-01-01

    Laccase has been obtained through two different production systems, the first using Pleurotus ostreatus in solid-state fermentation, the second one using Trametes versicolor in submerged culture. Different substrates (by products from yeast, flour and beverage industries) have been evaluated in both systems. Maximum laccase yield with Pleurotus ostreatus (25 u/ml) was obtained in a wheat bran medium. The maximum enzyme concentration level using Trametes versicolor (25 u/ml) was achieved in a submerged system, containing 10% vinasse, 4,5% wheat bran and 0,2% molasses per liter of waste. Culture filtrate extracted from Pleurotus ostreatus was used to remove phenol from wastewater. The enzymatic treatment is effective over a wide pH and temperature range. The Laccase treatment has been successfully used to dephenolize industrial petrol refinery wastewater. The advantage of Laccase dephenolization is that this enzyme uses molecular oxygen as an oxidant

  6. Enhancing acronym/abbreviation knowledge bases with semantic information.

    Science.gov (United States)

    Torii, Manabu; Liu, Hongfang

    2007-10-11

    In the biomedical domain, a terminology knowledge base that associates acronyms/abbreviations (denoted as SFs) with the definitions (denoted as LFs) is highly needed. For the construction such terminology knowledge base, we investigate the feasibility to build a system automatically assigning semantic categories to LFs extracted from text. Given a collection of pairs (SF,LF) derived from text, we i) assess the coverage of LFs and pairs (SF,LF) in the UMLS and justify the need of a semantic category assignment system; and ii) automatically derive name phrases annotated with semantic category and construct a system using machine learning. Utilizing ADAM, an existing collection of (SF,LF) pairs extracted from MEDLINE, our system achieved an f-measure of 87% when assigning eight UMLS-based semantic groups to LFs. The system has been incorporated into a web interface which integrates SF knowledge from multiple SF knowledge bases. Web site: http://gauss.dbb.georgetown.edu/liblab/SFThesurus.

  7. Culture medium for amylase production by toxigenic fungi

    Directory of Open Access Journals (Sweden)

    Figueira Edson Luiz Zangrando

    2000-01-01

    Full Text Available Mycelial growth and amylase production by a mycotoxigenic strain of Fusarium moniliforme and Aspergillus flavus were evaluated in a culture medium containing starch, glycerol, wheat bran or corn. With emphasis on corn, different fractions composed by germ, degermed seed, starch, milky stage corn and the respective starch or supernatant fraction were analyzed for F. moniliforme growth . The medium composed of milky stage corn supernatant promoted the best mycelial growth (p<0.05, and it was used to prepare amylase production medium in the next step. The medium composed with 2% ground corn in milky stage corn supernatant (350g of milky stage corn blended with 250mL water and centrifuged promoted the highest amylase production, which was at the 10th day of fermentation, both for F. moniliforme (42.32U/mL and A. flavus (4,745.54U/mL.

  8. The Potency of Dextranase from Arthrobacter sp. Strain B7 as Dental Plaque Removal

    Directory of Open Access Journals (Sweden)

    AFAF BAKTIR

    2005-12-01

    Full Text Available Dextranase of Arthrobacter sp. strain B7 (B7DEX enzyme was characterized in this study. This enzyme hydrolyzed sucrose and dextran, but not other glucans (starch, nigeran, cellulose, -soluble glucan. It also hydrolyzed glucan from dental plaque with the activity of 7.38 + 0.66 U/ml, where the activity toward dextran was 31.88 + 1.24 U/ml. The enzyme exhibited the pH optimum of 7 and the temperature optimum of 50 oC. Its optimum stability was at pH 7 and 50 oC. The enzyme was inhibited by Fe3+, Cu2+, Zn2+, and Ag+, but not by the anionic detergent (SDS and the nonionic detergent (Triton-X. The enzyme was activated by Ca2+, Na+, Mg2+, and saliva.

  9. Potensi Enzim Dekstranase dari Arthrobacter sp. Galur B7 sebagai Penghambat Plak Gigi

    Directory of Open Access Journals (Sweden)

    AFAF BAKTIR

    2005-12-01

    Full Text Available Dextranase of Arthrobacter sp. strain B7 (B7DEX enzyme was characterized in this study. This enzyme hydrolyzed sucrose and dextran, but not other glucans (starch, nigeran, cellulose, β-soluble glucan. It also hydrolyzed glucan from dental plaque with the activity of 7.38 ± 0.66 U/ml, where the activity toward dextran was 31.88 ± 1.24 U/ml. The enzyme exhibited the pH optimum of 7 and the temperature optimum of 50 °C. Its optimum stability was at pH 7 and 50 °C. The enzyme was inhibited by Fe3+, Cu2+, Zn2+, and Ag+, but not by the anionic detergent (SDS and the nonionic detergent (Triton-X. The enzyme was activated by Ca2+, Na+, Mg2+, and saliva.

  10. consistencia en dome: un caso de estudio

    Directory of Open Access Journals (Sweden)

    DANIEL CABARCAS

    2006-01-01

    Full Text Available Las herramientas metaCASE ofrecen una funcionalidad similar a la de las herramientas CASE convencionales para notaciones gráficas arbitrarias, una vez estas notaciones le sean especificadas adecuadamente. La principal dificultad de dichas herramientas es la especificación de las diferentes reglas de consistencia, que deben tenerse en cuenta cuando se usa una notación. En este artículo se presenta la especificación de dos reglas de consistencia del diagrama de clases de UML en el metaCASE DOME, codificadas en el lenguaje de programación Alter. Adicionalmente, se hace un análisis comparativo entre las especificaciones de los aspectos estructurales y de las reglas de consistencia en DOME y en la especificación de UML provista por el OMG.

  11. RANCANG BANGUN SISTEM E-RECRUITMENT BERBASIS ANDROID

    Directory of Open Access Journals (Sweden)

    Muhammad Taufik Syastra

    2017-08-01

    Full Text Available Rancang bangun sistem e-recruitment ini bertujuan untuk mengakomodir kebutuhan perusahaan yang berkaitan dengan proses rekrutmen karyawan. Pada penelitian ini mengambil studi pada PT Mega Petro Synergy (PT MPS. PT. MPS merupakan perusahaan yang bergerak dibidang penyedia rekayasa konstruksi dan tenaga kerja industri berat. Kebutuhan PT MPS saat ini berkaitan dengan minimalisir biaya iklan, data yang real time dan juga kesalahan akibat proses penginputan data pelamar. Perancangan diarahkan pada pengembangan aplikasi berbasis android yang terintegrasi pada Man Power Information System (MPIS. Model SDLC yang digunakan adalah Waterfall. Perancangan aplikasi ini menggunakan pemodelan Unified Modelling Languange (UML meliputi use case diagram, class diagram, activity diagram, dan sequence diagram. Selain UML, teknologi yang digunakan dalam proses perancangan adalah javascript, PHP, AngularJS, Laravel dan MySql. Penelitian ini menghasilkan aplikasi berbasis android yang dapat gunakan sebagai media iklan, penyedia data real time, serta mempermudah proses penginputan data pelamar.

  12. Response surface methodology for the optimization of alpha amylase production by serratia marcescens SB08

    International Nuclear Information System (INIS)

    Venil, C.K.; Lakshmanaperumalsamy, P.

    2008-01-01

    In this work, central composite design combining with response surface methodology was successfully employed to optimize medium composition for the production of alpha amylase by Serratia marcescens SB08 in submerged fermentation. The process parameters that influence the enzyme production were identified using Plackett- Burman design. Among the various factors screened, inoculum concentration, pH, NaCl and CaCl/sub 2/ were found to be most significant. The optimum level of pH was 5.0, inoculum concentration 3%, NaCl 0.30 g/l and CaCl/sub 2/ 0.13 g/l. The actual enzyme yield before and after optimization was 56.43 U/ml and 87.23 U/ml, respectively. Thus, it is advisable to the microbial industry sponsors to apply such profitable bioprocess to maintain high yield for mass production of alpha amylase. (author)

  13. Aggregation of thyroid autoantibodies in twins from opposite-sex pairs suggests that microchimerism may play a role in the early stages of thyroid autoimmunity

    DEFF Research Database (Denmark)

    Brix, Thomas Heiberg; Hansen, Pia Skov; Kyvik, Kirsten Ohm

    2009-01-01

    to play a role in the pathogenesis of thyroid autoimmunity. In that case, twins from opposite-sex pairs (OS) should have an increased risk of thyroid autoantibodies (TA). AIM: The aim of the study was to compare the frequency of TA in twin individuals from OS and monozygotic (MZ) twin pairs. Design...... positive if greater than 60 U/ml, greater than 60 U/ml, and greater than 1.0 U/liter, respectively. RESULTS: The frequency of TPOAb, TgAb, and TSHRAb among female cases was 15.0, 5.0, and 4.2%, respectively, which was higher than the corresponding prevalences in the female control population: 7.4% (P = 0...

  14. eSPEM - A SPEM Extension for Enactable Behavior Modeling

    Science.gov (United States)

    Ellner, Ralf; Al-Hilank, Samir; Drexler, Johannes; Jung, Martin; Kips, Detlef; Philippsen, Michael

    OMG's SPEM - by means of its (semi-)formal notation - allows for a detailed description of development processes and methodologies, but can only be used for a rather coarse description of their behavior. Concepts for a more fine-grained behavior model are considered out of scope of the SPEM standard and have to be provided by other standards like BPDM/BPMN or UML. However, a coarse granularity of the behavior model often impedes a computer-aided enactment of a process model. Therefore, in this paper we present eSPEM, an extension of SPEM, that is based on the UML meta-model and focused on fine-grained behavior and life-cycle modeling and thereby supports automated enactment of development processes.

  15. The Use of BPMN for Modelling The MES Level in Information and Control Systems

    Directory of Open Access Journals (Sweden)

    Peter Michalik

    2013-07-01

    Full Text Available This paper describes how to use the process map to model the MES level of information and control systems. In the practical application, the BPMN standard was used for the design of the function of the management maintenance, which, according MES organization, is one of the 11 basic MES functions. The application was implemented on the flexible production line, located in the laboratory at the Department of Cybernetics and Artificial Intelligence. In this article, there is only one BPMN model of  a MES function from the set of modelled functions in our laboratory. These functions were also modelled by the UML Activity Diagram. Although the UML model is not included in this article, there is a comparison of these approaches based on selected criteria and our experiences with modelling in the laboratory at the university.

  16. Performance evaluation of enterprise architecture using fuzzy sequence diagram

    Directory of Open Access Journals (Sweden)

    Mohammad Atasheneh

    2014-01-01

    Full Text Available Developing an Enterprise Architecture is a complex task and to control the complexity of the regulatory framework we need to measure the relative performance of one system against other available systems. On the other hand, enterprise architecture cannot be organized without the use of a logical structure. The framework provides a logical structure for classifying architectural output. Among the common architectural framework, the C4ISR framework and methodology of the product is one of the most popular techniques. In this paper, given the existing uncertainties in system development and information systems, a new version of UML called Fuzzy-UML is proposed for enterprise architecture development based on fuzzy Petri nets. In addition, the performance of the system is also evaluated based on Fuzzy sequence diagram.

  17. ANALISA DAN PERANCANGAN WEB SITE SOCIAL-COMMERCE UMKM

    Directory of Open Access Journals (Sweden)

    Endang Supriyati

    2016-04-01

    Full Text Available Pertumbuhan internet mengubah perilaku konsumen dalam mengambil keputusan. Pertukaran informasi melalui media sosial menjadi referensi penting bagi konsumen dalam mengambil keputusan pembelian. Transaksi bisnis secara online dan kesuksesan e-commerce tergantung pada ketepatan desain dari sebuah produk. Setiap situs social commerce, paling tidak mempunyai satu set minimal fitur desain social commerce. UMKM merupakan salah satu tiang ekonomi bangsa. Salah satu permasalahan pada UMKM adalah pemasaran produk. Untuk membangun UMKM yang lebih kuat dalam pemasaran maka perlu dibuat website yang mampu memasarkan produk secara lebih luas. Dengan adanya social commerce, akan mampu memasarkan produk, merekomendasi produk dan menampilkan berbagai informasi produk-produk UMKM. Sebelum membangun sistem, didahului dengan perancangan sistem, perancangan ini menggunakan UML (Unified Modeling Language. Hasil penelitian ini berupa rancangan website social commerce untuk UMKM. Kata kunci: social commerce, UMKM, UML.

  18. Refinement and verification in component-based model-driven design

    DEFF Research Database (Denmark)

    Chen, Zhenbang; Liu, Zhiming; Ravn, Anders Peter

    2009-01-01

    Modern software development is complex as it has to deal with many different and yet related aspects of applications. In practical software engineering this is now handled by a UML-like modelling approach in which different aspects are modelled by different notations. Component-based and object-o...... be integrated in computer-aided software engineering (CASE) tools for adding formally supported checking, transformation and generation facilities.......Modern software development is complex as it has to deal with many different and yet related aspects of applications. In practical software engineering this is now handled by a UML-like modelling approach in which different aspects are modelled by different notations. Component-based and object...

  19. Towards a portal and search engine to facilitate academic and research collaboration in engineering and education

    Science.gov (United States)

    Bonilla Villarreal, Isaura Nathaly

    While international academic and research collaborations are of great importance at this time, it is not easy to find researchers in the engineering field that publish in languages other than English. Because of this disconnect, there exists a need for a portal to find Who's Who in Engineering Education in the Americas. The objective of this thesis is to built an object-oriented architecture for this proposed portal. The Unified Modeling Language (UML) model developed in this thesis incorporates the basic structure of a social network for academic purposes. Reverse engineering of three social networks portals yielded important aspects of their structures that have been incorporated in the proposed UML model. Furthermore, the present work includes a pattern for academic social networks..

  20. Unified Approach in the DSS Development Process

    Directory of Open Access Journals (Sweden)

    2007-01-01

    Full Text Available The structure of today's decision support environment become very complex due to new generation of Business Intelligence applications and technologies like Data Warehouse, OLAP (On Line Analytical Processing and Data Mining. In this respect DSS development process are not simple and needs an adequate methodology or framework able to manage different tools and platforms to achieve manager's requirements. The DSS development process must be view like a unified and iterative set of activities and operations. The new techniques based on Unified Process (UP methodology and UML (Unified Modeling Language it seems to be appropriate for DSS development using prototyping and RAD (Rapid Application Development techniques. In this paper we present a conceptual framework for development and integrate Decision Support Systems using Unified Process Methodology and UML.

  1. Implementation and application study on 3D collaborative design for CFETR based on ENOVIA VPM

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Ling-Long, E-mail: linglonglin@ipp.ac.cn [Tokamak Design Division, Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui 230031 (China); Song, Yun-Tao [Tokamak Design Division, Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui 230031 (China); School of Nuclear Science and Technology, University of Science and Technology of China, Hefei, Anhui 230026 (China); Tang, Yu-Xiang [Tokamak Design Division, Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui 230031 (China); Du, Qing-Qing [Hefei Keju Cryogenics Co., Ltd., Hefei, Anhui 230031 (China); Gong, Yi-Peng [Shanghai ATOZ Group Co., Ltd., Shanghai 201611, P.R. China. (China)

    2015-11-15

    China Fusion Engineering Test Reactor (CFETR) is an ITER-like superconducting tokamak device and it is under conceptual design. The paper is to highlight the building of the collaborative platform and its application in design work. First, a collaborative framework between collaborators is proposed and a method based-on Riverbed to optimize WAN is adopted to improve the data transmission. Then it proposes a Unified Modeling Language (UML) approach for specification of PDM (Product Documents Management) system implementation to enable management of whole product data and related information about its entire lifecycle. At last, the chosen approach for modeling based on UML is detailed and the relational design based-on skeleton is instanced for CFETR.

  2. Seleção de diferentes meios para produção de lipase a partir de Bacillis licheniformis (UCP 1014

    Directory of Open Access Journals (Sweden)

    Ladiel Luiz Pedrozo Tavares

    2011-01-01

    Full Text Available Development of alternative culture media for microbial enzyme production have been widely exploited in recent decades. The microbial lipases are extracellular enzymes produced in fermentation processes, which favors its extraction, isolation and purification. Bacillus are Gram-positive bacteria, saprophytes, of great importance in various industrial sectors. In this study, we tested three methods of production using B. licheniformis (UCP 1014 media called A, B and C. The kinetics of enzyme production occurred in orbital shaker at 150 rpm, 37 °C, for 96 hours. The collected samples were subjected to the construction of the growth curve, determination of pH and lipolytic activity. The results indicated a better growth in the middle C showing an activity of 256 U/mL, while the means A and B had values of 170 and 153 U/mL, respectively. The results showed that the middle C presented higher enzyme production in the tests.

  3. Implementation and application study on 3D collaborative design for CFETR based on ENOVIA VPM

    International Nuclear Information System (INIS)

    Lin, Ling-Long; Song, Yun-Tao; Tang, Yu-Xiang; Du, Qing-Qing; Gong, Yi-Peng

    2015-01-01

    China Fusion Engineering Test Reactor (CFETR) is an ITER-like superconducting tokamak device and it is under conceptual design. The paper is to highlight the building of the collaborative platform and its application in design work. First, a collaborative framework between collaborators is proposed and a method based-on Riverbed to optimize WAN is adopted to improve the data transmission. Then it proposes a Unified Modeling Language (UML) approach for specification of PDM (Product Documents Management) system implementation to enable management of whole product data and related information about its entire lifecycle. At last, the chosen approach for modeling based on UML is detailed and the relational design based-on skeleton is instanced for CFETR.

  4. Optimization of media composition for Nattokinase production by Bacillus subtilis using response surface methodology.

    Science.gov (United States)

    Deepak, V; Kalishwaralal, K; Ramkumarpandian, S; Babu, S Venkatesh; Senthilkumar, S R; Sangiliyandi, G

    2008-11-01

    Response surface methodology and central composite rotary design (CCRD) was employed to optimize a fermentation medium for the production of Nattokinase by Bacillus subtilis at pH 7.5. The four variables involved in this study were Glucose, Peptone, CaCl2, and MgSO4. The statistical analysis of the results showed that, in the range studied; only peptone had a significant effect on Nattokinase production. The optimized medium containing (%) Glucose: 1, Peptone: 5.5, MgSO4: 0.2 and CaCl2: 0.5 resulted in 2-fold increased level of Nattokinase (3194.25U/ml) production compared to initial level (1599.09U/ml) after 10h of fermentation. Nattokinase production was checked with fibrinolytic activity.

  5. Plasma thromboplastin antecedent (PTA, factor XI): a specific and sensitive radioimmunoassay

    International Nuclear Information System (INIS)

    Saito, H.; Goldsmith, G.H. Jr.

    1977-01-01

    A specific, sensitive, and reproducible radioimmunoassay for human plasma thromboplastin antecedent (PTA, factor XI) has been developed with purified PTA and monospecific rabbit antiserum. Precise measurements of PTA antigen were possible for concentrations as low as 0.3% of that in normal pooled plasma. Normal plasma contained approximately 6 μg PTA/ml. A good correlation (correlation coefficient 0.68) existed between the PTA procoagulant assays and radioimmunoassays among 50 normal adults (25 males and 25 females). PTA antigen was markedly reduced in plasma of 13 patients with congenital homozygous PTA deficiency (range <0.003-0.128 U/ml) and 9 patients with hepatic cirrhosis (0.35 +- 0.17 U/ml), but was normal in those of 9 patients under treatment with warfarin, 8 patients with disseminated intravascular coagulation and 16 patients with other congenital clotting factor abnormalities, including prekallikrein deficiency (Fletcher trait) and high molecular weight kininogen deficiency

  6. Pedunculated uterine leiomyoma associated with pseudo-Meigs' syndrome and elevated CA-125 level: CT features

    Energy Technology Data Exchange (ETDEWEB)

    Kebapci, Mahmut; Aslan, Ozgur; Kaya, Tamer [Department of Radiology, Osmangazi University School of Medicine, Meselik, 26480 Eskisehir (Turkey); Yalcin, Omer T.; Ozalp, Sinan [Department of Obstetrics and Gynecology, Osmangazi University School of Medicine, Meselik, 26480 Eskisehir (Turkey)

    2002-07-01

    A 38-year-old woman presented with a 1-week history of low back pain, distension, weakness, and loss of appetite. Laboratory studies showed a serum CA-125 level of 281 U/ml (normal value 1.2-32 U/ml). Abdominopelvic sonography revealed massive ascites, left pleural effusion, and a heterogeneous, hypoechogenic, and smoothly outlined solid mass. The mass had a close proximity and to the anterior side of the right ovary. Doppler sonography showed that the mass was hypervascularized. Computed tomography demonstrated numerous, tortuous vascular structures around the mass and along the omentum indicating its auxiliary vascularization from the omentum. Exploratory laparotomy and histopathological examination revealed pedunculated leiomyoma with parasitized blood supply from the omentum. Ascites and pleural effusion disappeared 6 months after surgery. We present the clinical and CT features of a parasitic leiomyoma adhering to the omentum. (orig.)

  7. Model-Driven Configuration of SELinux Policies

    Science.gov (United States)

    Agreiter, Berthold; Breu, Ruth

    The need for access control in computer systems is inherent. However, the complexity to configure such systems is constantly increasing which affects the overall security of a system negatively. We think that it is important to define security requirements on a non-technical level while taking the application domain into respect in order to have a clear and separated view on security configuration (i.e. unblurred by technical details). On the other hand, security functionality has to be tightly integrated with the system and its development process in order to provide comprehensive means of enforcement. In this paper, we propose a systematic approach based on model-driven security configuration to leverage existing operating system security mechanisms (SELinux) for realising access control. We use UML models and develop a UML profile to satisfy these needs. Our goal is to exploit a comprehensive protection mechanism while rendering its security policy manageable by a domain specialist.

  8. Financial Ratio Analysis: the Development of a Dedicated Management Information System

    Directory of Open Access Journals (Sweden)

    Voicu-Dan Dragomir

    2007-01-01

    Full Text Available This paper disseminates the results of the development process for a financial analysis information system. The system has been subject to conceptual design using the Unified Modeling Language (UML and has been implemented in object-oriented manner using the Visual Basic .NET 2003 programming language. The classic financial analysis literature is focused on the chain-substitution method of computing the prior-year to current-year variation of linked financial ratios. We have applied this technique on the DuPont System of analysis concerning the Return on Equity ratio, by designing several structural UML diagrams depicting the breakdown and analysis of each financial ratio involved. The resulting computer application offers a flexible approach to the analytical tools: the user is required to introduce the raw data and the system provides both table-style and charted information on the output of computation. User-friendliness is also a key feature of this particular financial analysis application.

  9. Karakterisasi ekstrak kasar fitase termofilik dari bakteri kawah Ijen Banyuwangi, isolat AP-17

    Directory of Open Access Journals (Sweden)

    Aline Puspita Kusumadjaja

    2010-12-01

    Full Text Available Crude thermophilic phytase was produced by isolate AP-17 that has been isolated from Ijen Crater Banyuwangi. Based on Gram test, isolate AP-17 was gram positive spore forming rod shape bacteria so that it was identified as Bacillus sp. AP-17. Crude thermophilic phytase isolated from Bacillus sp. AP-17 had the optimum temperature at 75 ° C with activity of 0.1413 U/ml, and its optimum pH was at pH 6 with activity of 0.0875 U/ml. The enzyme was stable when heated at 75 ° C for three hours and still had 90% activity when it was exposed at pH 5 €“8, optimum temperature, for one hour.

  10. The caBIG® Life Science Business Architecture Model.

    Science.gov (United States)

    Boyd, Lauren Becnel; Hunicke-Smith, Scott P; Stafford, Grace A; Freund, Elaine T; Ehlman, Michele; Chandran, Uma; Dennis, Robert; Fernandez, Anna T; Goldstein, Stephen; Steffen, David; Tycko, Benjamin; Klemm, Juli D

    2011-05-15

    Business Architecture Models (BAMs) describe what a business does, who performs the activities, where and when activities are performed, how activities are accomplished and which data are present. The purpose of a BAM is to provide a common resource for understanding business functions and requirements and to guide software development. The cancer Biomedical Informatics Grid (caBIG®) Life Science BAM (LS BAM) provides a shared understanding of the vocabulary, goals and processes that are common in the business of LS research. LS BAM 1.1 includes 90 goals and 61 people and groups within Use Case and Activity Unified Modeling Language (UML) Diagrams. Here we report on the model's current release, LS BAM 1.1, its utility and usage, and plans for future use and continuing development for future releases. The LS BAM is freely available as UML, PDF and HTML (https://wiki.nci.nih.gov/x/OFNyAQ).

  11. Hematological measurements in rats flown on Spacelab shuttle SL-3

    International Nuclear Information System (INIS)

    Lange, R.D.; Andrews, R.B.; Gibson, L.A.; Congdon, C.C.; Wright, P.; Dunn, C.D.R.; Jones, J.B.

    1987-01-01

    Previous studies have shown that a decrease in red cell mass occurs in astronauts, and some studies indicate a leukocytosis occurs. A life science module housing young and mature rats was flown on shuttle mission Spacelab 3 (SL-3), and the results of hematology studies of flight and control rats are presented. Statistically significant increases in the hematocrit, red blood cell counts, and hemoglobin determinations, together with a mild neutrophilia and lymphopenia, were found in flight animals. No significant changes were found in bone marrow and spleen cell differentials or erythropoietin determinations. Clonal assays demonstrated an increased erythroid colony formation of flight animal bone marrow cells at erythropoietin doses of 0.02 and 1.0 U/ml but not 0.20 U/ml. These results agree with some but vary from other previously published studies. Erythropoietin assays performed by radioimmunoassay and clonal studies were performed for the first time

  12. Tumour associated antigen CA-50, CA-242 immunoradiometric assay (IRMA) in genitourinary malignancy and gastrointestinal carcinoma early diagnosis

    International Nuclear Information System (INIS)

    Chen Zhizhou.

    1992-04-01

    Tumour markers CA-50 and CA-242 were measured by immunometric assay (IRMA) to investigate their usefulness in the diagnosis of cancer of the pancreas, biliary tract, liver, breast, lung, gastrointestinal and genitourinary systems. The cutoff points, derived from studies on normal subjects and those with proven benign disease, were 20 u/ml and 12 u/ml for CA-50 and CA-242 respectively. Both markers were found to be generally useful with significant differences between malignant and non malignant disease. The highest positive rates, were found in cancers of the pancreas and gall bladder. The overall rate of false positives was low. It is concluded that measurements of CA-50 and CA-242 are useful in the detection of malignancy, particularly of the pancreas and biliary tract. 2 figs, 2 tabs

  13. The prognostic value of pre-operative serum tetranectin, CA-125 and a combined index in women with primary ovarian cancer

    DEFF Research Database (Denmark)

    Høgdall, Claus K; Nørgaard-Pedersen, Bent; Mogensen, Ole

    2002-01-01

    cancer. Evaluation was by univariate life-tables analyses and the multivariate Cox analysis. In the Cox analyses, the variables were tested respectively in actual values and as dichotomy variables with different cut-off levels: 6.7, 7.3 and 8.2 mg/l for TN, 35, 65, 100 and 165 U/ml for CA125. RESULTS....... The variables may be useful in the selection of patients with a poor outcome for new treatment strategies....

  14. NPA4K development system using object-oriented methodology

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Kwang Seong; Hahn, Do Hee

    2000-11-01

    NPA4K consists of module programs with several components for various functions. Software components have to be developed systematically by compartment criteria and design method. In this paper, the understandings of a typical Object-Oriented Methodology , UML(Unified Modeling Language), the procedure for NPA4K program development and the architecture for long-term development of NPA4K are introduced.

  15. Artificial Intelligence versus Statistical Modeling and Optimization of Cholesterol Oxidase Production by using Streptomyces Sp.

    Science.gov (United States)

    Pathak, Lakshmi; Singh, Vineeta; Niwas, Ram; Osama, Khwaja; Khan, Saif; Haque, Shafiul; Tripathi, C K M; Mishra, B N

    2015-01-01

    Cholesterol oxidase (COD) is a bi-functional FAD-containing oxidoreductase which catalyzes the oxidation of cholesterol into 4-cholesten-3-one. The wider biological functions and clinical applications of COD have urged the screening, isolation and characterization of newer microbes from diverse habitats as a source of COD and optimization and over-production of COD for various uses. The practicability of statistical/ artificial intelligence techniques, such as response surface methodology (RSM), artificial neural network (ANN) and genetic algorithm (GA) have been tested to optimize the medium composition for the production of COD from novel strain Streptomyces sp. NCIM 5500. All experiments were performed according to the five factor central composite design (CCD) and the generated data was analysed using RSM and ANN. GA was employed to optimize the models generated by RSM and ANN. Based upon the predicted COD concentration, the model developed with ANN was found to be superior to the model developed with RSM. The RSM-GA approach predicted maximum of 6.283 U/mL COD production, whereas the ANN-GA approach predicted a maximum of 9.93 U/mL COD concentration. The optimum concentrations of the medium variables predicted through ANN-GA approach were: 1.431 g/50 mL soybean, 1.389 g/50 mL maltose, 0.029 g/50 mL MgSO4, 0.45 g/50 mL NaCl and 2.235 ml/50 mL glycerol. The experimental COD concentration was concurrent with the GA predicted yield and led to 9.75 U/mL COD production, which was nearly two times higher than the yield (4.2 U/mL) obtained with the un-optimized medium. This is the very first time we are reporting the statistical versus artificial intelligence based modeling and optimization of COD production by Streptomyces sp. NCIM 5500.

  16. Screening of agricultural wastes as a medium production of catalase for enzymatic fuel cell by Neurospora crassa InaCC F226

    Science.gov (United States)

    Santoso, Pugoh; Yopi

    2017-12-01

    Explorations of local microorganisms from Indonesia that can produce of catalase are still limited. Neurospora crassa is a fungus which resulting of two kinds of catalase, namely catalase-1 and catalase-3. We studied the production of catalase by Neurospora crassa (no. F226) from Indonesia Culture Collection (InaCC) in Solid State Fermentation (SSF). Among four screened agro wastes (corn cob, rice straw, oil palm empty fruit bunches, and bagasse), rice straw and oil palm empty fruit bunches (OPEFB) were remarked as the most promising substrate suited for the excellent growth and adequate production of catalase. Based on the result, the method of solid state fermentation was suitable to production of catalase. It is caused that the medium served to maintain microbial growth and metabolism. The filamentous filament is more suitable for living on solid media because it has a high tolerance to low water activity, and it has a high potential to excrete hydrolytic enzymes that caused of its morphology. The filamentous filament morphology allows the fungus to form colonies and penetrate the solid substrates in order to obtain nutrients. The results showed that the highest catalase activity was obtained on rice straw and oil palm empty fruit bunches medium with catalase activity of 39.1 U/mL and 37,7 U/mL in 50% moisture content medium, respectively. Optimization of humidity and pH medium in the rice straw were investigated which is the highest activity obtained in 30% moisture content and pH medium of 6. The catalase activity was reached in the value of 53.761 U/mL and 56.903 U/mL by incubated 48 hours and 96 hours, respectively.

  17. Improving Non-Linear Approaches to Anomaly Detection, Class Separation, and Visualization

    Science.gov (United States)

    2014-12-26

    of times pregnant , plasma glucose concentration at two hours in an oral glucose tolerance test, diastolic blood pressure (mm Hg), triceps skin fold...thickness (mm), two-hour serum insulin (mu U/ml), body mass index (weight in kg/(height in m)2), diabetes pedigree function, and age (years). Patients...essentially smooths the skeleton by using the centroids instead of exemplars, and so k-means is more resistant to outliers. Therefore, it is chosen to

  18. Analysis and Comparison of Various Requirements Management Tools for Use in the Shipbuilding Industry

    Science.gov (United States)

    2006-09-01

    Systems Engineering Management Plan SEPO Systems Engineering Process Office SPAWAR Space and Naval Warfare xvi SQL Structured Query Language...supports getting data from the database as well as writing into the database. The API also supports VB and VBA No Response Added. 80 applications. Thus...standard query access) Yes, Cradle supports UML Modeling; RTF, MIF, OPS for document exchange; SQL via external RDB engine; and CSV for data exchange

  19. Can preoperative and postoperative CA19-9 levels predict survival and early recurrence in patients with resectable hilar cholangiocarcinoma?

    Science.gov (United States)

    Wang, Jun-Ke; Hu, Hai-Jie; Shrestha, Anuj; Ma, Wen-Jie; Yang, Qin; Liu, Fei; Cheng, Nan-Sheng; Li, Fu-Yu

    2017-07-11

    To investigate the predictive values of preoperative and postoperative serum CA19-9 levels on survival and other prognostic factors including early recurrence in patients with resectable hilar cholangiocarcinoma. In univariate analysis, increased preoperative and postoperative CA19-9 levels in the light of different cut-off points (37, 100, 150, 200, 400, 1000 U/ml) were significantly associated with poor survival outcomes, of which the cut-off point of 150 U/ml showed the strongest predictive value (both P 150 U/ml was significantly associated with lymph node metastasis (OR = 3.471, 95% CI 1.216-9.905; P = 0.020) and early recurrence (OR = 8.280, 95% CI 2.391-28.674; P = 0.001). Meanwhile, postoperative CA19-9 level > 150 U/ml was also correlated with early recurrence (OR = 4.006, 95% CI 1.107-14.459; P = 0.034). Ninety-eight patients who had undergone curative surgery for hilar cholangiocarcinoma between 1995 and 2014 in our institution were selected for the study. The correlations of preoperative and postoperative serum CA19-9 levels on the basis of different cut-off points with survival and various tumor factors were retrospectively analyzed with univariate and multivariate methods. In patients with resectable hilar cholangiocarcinoma, serum CA19-9 predict survival and early recurrence. Patients with increased preoperative and postoperative CA19-9 levels have poor survival outcomes and higher tendency of early recurrence.

  20. Circulating ACE2 activity correlates with cardiovascular disease development

    Directory of Open Access Journals (Sweden)

    Katalin Úri

    2016-12-01

    Full Text Available It was shown recently that angiotensin-converting enzyme activity is limited by endogenous inhibition in vivo, highlighting the importance of angiotensin II (ACE2 elimination. The potential contribution of the ACE2 to cardiovascular disease progression was addressed. Serum ACE2 activities were measured in different clinical states (healthy, n=45; hypertensive, n=239; heart failure (HF with reduced ejection fraction (HFrEF n=141 and HF with preserved ejection fraction (HFpEF n=47. ACE2 activity was significantly higher in hypertensive patients (24.8±0.8 U/ml than that in healthy volunteers (16.2±0.8 U/ml, p=0.01. ACE2 activity further increased in HFrEF patients (43.9±2.1 U/ml, p=0.001 but not in HFpEF patients (24.6±1.9 U/ml when compared with hypertensive patients. Serum ACE2 activity negatively correlated with left ventricular systolic function in HFrEF, but not in hypertensive, HFpEF or healthy populations. Serum ACE2 activity had a fair diagnostic value to differentiate HFpEF from HFrEF patients in this study. Serum ACE2 activity correlates with cardiovascular disease development: it increases when hypertension develops and further increases when the cardiovascular disease further progresses to systolic dysfunction, suggesting that ACE2 metabolism plays a role in these processes. In contrast, serum ACE2 activity does not change when hypertension progresses to HFpEF, suggesting a different pathomechanism for HFpEF, and proposing a biomarker-based identification of these HF forms.

  1. Heterogeneity Within Macrophage Populations: A Possible Role for Colony Stimulating Factors

    Science.gov (United States)

    1988-04-04

    highest concentration ofriFN-yused (5.0 U/ml), a depression of T cell proliferation induced by the antigen-pulsed rGM-CSF-derived macrophages was...stimulation by rGM-CSF and nCSF-1 in bone marrow cells derived from normal mice and mice 3 and 7 days post-treatment with 5FU . Bone marrow cells

  2. T-Check in Technologies for Interoperability: Business Process Management in a Web Services Context

    Science.gov (United States)

    2008-09-01

    UML Sequence Diagram) 6  Figure 3:   BPMN Diagram of the Order Processing Business Process 9  Figure 4:   T-Check Process for Technology Evaluation 10...Figure 5:  Notional System Architecture 12  Figure 6:  Flow Chart of the Order Processing Business Process 14  Figure 7:  Order Processing Activities...features. Figure 3 (created with Intalio BPMS Designer [Intalio 2008]) shows a BPMN view of the Order Processing business process that is used in the

  3. Proposed Framework which Uses Object Oriented Principles in Relational Systems: Structure and Formating (Part 2)

    OpenAIRE

    Catalin STRIMBEI

    2006-01-01

    Our approach tries to overcome the limitations of so called “flat nature†of relational systems, in the actual context of actual relational database theories, database systems technologies and object oriented methodologies by proposing an MDA framework to map an object oriented (UML formalized) model to object-relational structures of today’s database systems.

  4. The application of coloured Petri nets to verification of distributed systems specified by message Sequence Charts

    OpenAIRE

    CHERNENOK S.A.; NEPOMNIASCHY V.A.

    2015-01-01

    The language of message sequence charts (MSC) is a popular scenario-based specification language used to describe the interaction of components in distributed systems. However, the methods for validation of MSC diagrams are underdeveloped. This paper describes a method for translation of MSC diagrams into coloured Petri nets (CPN). The method is applied to the property verification of these diagrams. The considered set of diagram elements is extended by the elements of UML sequence diagrams a...

  5. Seminario C++, parte 2

    OpenAIRE

    Cachero Castro, Cristina; Ponce de León Amador, Pedro José

    2007-01-01

    Este seminario trata sobre principios de orientación a objetos con C++. Para comprender mejor sus contenidos, se debe tener un conocimiento básico sobre programación estructurada con C++ o C. El compilador g++. Directivas de compilación. Make. Doxygen. Utilidad de compresión 'tar'. Introducción a UML. Ejercicio práctico.

  6. NPA4K development system using object-oriented methodology

    International Nuclear Information System (INIS)

    Jeong, Kwang Seong; Hahn, Do Hee

    2000-11-01

    NPA4K consists of module programs with several components for various functions. Software components have to be developed systematically by compartment criteria and design method. In this paper, the understandings of a typical Object-Oriented Methodology , UML(Unified Modeling Language), the procedure for NPA4K program development and the architecture for long-term development of NPA4K are introduced

  7. An 00 visual language definition approach supporting multiple views

    OpenAIRE

    Akehurst, David H.; I.E.E.E. Computer Society

    2000-01-01

    The formal approach to visual language definition is to use graph grammars and/or graph transformation techniques. These techniques focus on specifying the syntax and manipulation rules of the concrete representation. This paper presents a constraint and object-oriented approach to defining visual languages that uses UML and OCL as a definition language. Visual language definitions specify a mapping between concrete and abstract models of possible visual sentences, which carl subsequently be ...

  8. The Analysis of the Value of the Thyroid Autoantibody Measured by Radioimmunoassay

    International Nuclear Information System (INIS)

    Chung, Jae Hoon; Lee, Myung Shik; Cho, Bo Youn; Lee, Hong Kyu; Koh, Chang Soon; Min, Hun Ki; Lee, Mun Ho

    1987-01-01

    To evaluate the values of the thyroid autoantibody measured by radioimmunoassay (RIA) and compare it with hemagglutination method (HA) in the normal and the thyroid disease, data were obtained from total 618 persons; 236 healthy persons, 217 patients with Graves disease (including 113 patients with undertreated Graves' disease), 100 Hashimoto's disease, 31 thyroid nodule, and 34 simple goiter. RSR kit made in England was used and could be detected at least 3 U/ml. The positive rates of normal group were antirnicrosomal antibody (AMA) 31.8%, antithyroglobulin antibody (ATA) 44.5% by RIA and there was no considerable change in sex and age distribution. In Graves disease, the positive rates of AMA and ATA were 90.4, 76.9% by RIA, 85, 39% by HA. In Hashimoto's disease, 94,91% by RIA, and 87,48% by HA, respectively. The autoantibody titer by RIA in thyroid autoimmune disease as welt as in normal group was more sensitive than that by HA, especially in ATA. There were linear relationships between the titer of RIA and that of HA in AMA of Graves disease and AMA and ATA of Hashimotos disease. There was no relationship among thyroid autoantibody, free T, index, TBII, and TSH. The titers of AMA and ATA were found to decrease in patients with Graves disease during the course of antithyroid drug therapy. Of the 236 normal subjects, thirty-seven (15.7%) had concentrations of above 7.5 U/ml in AMA, forty-four (18. 6%) above 9 U/ml in ATA. These values were considered as the upper limit for the normal range. In Graves disease, 82,7, 53.8% were above 7.5, 9 U/ml, respectively; In Hashimoto's disease, HZ, 79% were positive. We conclude that RIA was more sensitive than HA in measuring the thyroid autoantibody, but we will study further more for determining the normal range and its interpretation.

  9. Positive correlation between serum and peritoneal fluid CA-125 levels in women with pelvic endometriosis

    Directory of Open Access Journals (Sweden)

    Vivian Ferreira do Amaral

    Full Text Available CONTEXT AND OBJECTIVE: One of the diagnostic markers of endometriosis is CA-125, and elevated levels of this are caused by high concentrations in the ectopic endometrium. The objective of this study was to correlate CA-125 levels in serum and peritoneal fluid from women with and without pelvic endometriosis. DESIGN AND SETTING: This was a prospective, cross-sectional, controlled study of consecutive pa-tients undergoing laparoscopy for infertility, pelvic pain or tubal ligation, during early follicular phase, at the university hospital of Faculdade de Medicina de Ribeirão Preto. METHODS: Fifty-two patients were divided into two groups: endometriosis group, consisting of 35 patients with biopsy-confirmed pelvic endometriosis, and control group, consisting of 17 patients without endometriosis. CA-125 levels in serum samples and peritoneal fluid were determined by chemiluminescence. RESULTS: CA-125 levels in serum and peritoneal fluid were higher in patients with advanced pelvic endometriosis (means of 39.1 ± 45.8 U/ml versus 10.5 ± 5.9 U/ml in serum, p < 0.005; 1,469.4 ± 1,350.4 U/ml versus 888.7 ± 784.3 U/ml in peritoneal fluid, p < 0.05, and showed a positive correlation between each other (correlation coefficient (r = 0.4880. Women with more advanced degrees of endometriosis showed higher CA-125 levels in both serum and peritoneal fluid (p = 0.0001. CONCLUSION: There is a positive correlation between serum and peritoneal fluid values of CA-125 in women with and without endometriosis, and their levels are higher in peritoneal fluid. Advanced endometriosis is related to higher levels in both serum and peritoneal fluid.

  10. Soluble CD30 and HLA antibodies as potential risk factors for kidney transplant rejection.

    Science.gov (United States)

    Slavcev, Antonij; Lácha, Jiri; Honsová, Eva; Sajdlová, Helena; Lodererová, Alena; Vitko, Stefan; Skibová, Jelena; Striz, Ilja

    2005-06-01

    Recent literary data suggest that high pre- and post-transplant serum levels of the soluble CD30 (sCD30) molecule may be a risk factor for acute rejection and worse prognosis of the transplanted kidney. The aim of our study was to correlate the concentrations of sCD30 and the presence of HLA antibodies as defined by flow cytometry and ELISA with the clinical course and graft prognosis after transplantation. One hundred and seventeen kidney transplant patients were included into the study. The incidence of rejection episodes, graft function and graft survival for up to 1 year post-transplant were evaluated. Soluble CD30 levels before transplantation were virtually the same in patients who experienced rejection and in non-rejecting patients. In both patient groups, a significant decrease of sCD30 was detected 2 weeks after transplantation (104.4 U/ml before vs. 37.0 U/ml post-transplant, P sCD30 between rejecting and non-rejecting patients. Patients without rejection had lower sCD30 values (31.2 U/ml post-transplant) compared to patients who experienced rejection episodes (62.9 U/ml), P antigens and elevated concentrations of sCD30 shortly after transplantation were associated with increased risk for acute rejection in the first post-transplant year. Measurement of soluble CD30 after transplantation, taken into consideration with the presence of HLA class II antibodies, might be helpful for evaluating the potential risk for acute rejection.

  11. High variation of individual soluble serum CD30 levels of pre-transplantation patients: sCD30 a feasible marker for prediction of kidney allograft rejection?

    Science.gov (United States)

    Altermann, Wolfgang; Schlaf, Gerald; Rothhoff, Anita; Seliger, Barbara

    2007-10-01

    Previous studies have suggested that the pre-transplant levels of the soluble CD30 molecule (sCD30) represent a non-invasive tool which can be used as a biomarker for the prediction of kidney allograft rejections. In order to evaluate the feasibility of sCD30 for pre-transplantation monitoring the sera of potential kidney recipients (n = 652) were collected four times in a 3 months interval. Serum from healthy blood donors (n = 203) served as controls. The sCD30 concentrations of all samples were determined using a commercially available ELISA. This strategy allowed the detection of possible variations of individual sCD30 levels over time. Heterogeneous sCD30 concentrations were found in the samples obtained from individual putative kidney transplant recipients when quarterly measured over 1 year. Total 95% of serum samples obtained from healthy controls exhibited sCD30 values 30 U/ml). Total 524 patients (80.4%) constantly exhibited serum concentrations of sCD30 values >100 U/ml was significantly lower than that previously reported. The high degree of variation does not allow the stratification of patients into high and low immunological risk groups based on a single sCD30 value > 100 U/ml. Due to the heterogeneity of sCD30 levels during time course and the high values of SD, its implementation as a pre-transplant marker cannot be justified to generate special provisions for the organ allocation to patients with single sCD30 values > 100 U/ml.

  12. Using Distributed Representations to Disambiguate Biomedical and Clinical Concepts

    OpenAIRE

    Tulkens, Stéphan; Šuster, Simon; Daelemans, Walter

    2016-01-01

    In this paper, we report a knowledge-based method for Word Sense Disambiguation in the domains of biomedical and clinical text. We combine word representations created on large corpora with a small number of definitions from the UMLS to create concept representations, which we then compare to representations of the context of ambiguous terms. Using no relational information, we obtain comparable performance to previous approaches on the MSH-WSD dataset, which is a well-known dataset in the bi...

  13. Translating the foundational model of anatomy into french using knowledge-based and lexical methods

    Directory of Open Access Journals (Sweden)

    Merabti Tayeb

    2011-10-01

    Full Text Available Abstract Background The Foundational Model of Anatomy (FMA is the reference ontology regarding human anatomy. FMA vocabulary was integrated into the Health Multi Terminological Portal (HMTP developed by CISMeF based on the CISMeF Information System which also includes 26 other terminologies and controlled vocabularies, mainly in French. However, FMA is primarily in English. In this context, the translation of FMA English terms into French could also be useful for searching and indexing French anatomy resources. Various studies have investigated automatic methods to assist the translation of medical terminologies or create multilingual medical vocabularies. The goal of this study was to facilitate the translation of FMA vocabulary into French. Methods We compare two types of approaches to translate the FMA terms into French. The first one is UMLS-based on the conceptual information of the UMLS metathesaurus. The second method is lexically-based on several Natural Language Processing (NLP tools. Results The UMLS-based approach produced a translation of 3,661 FMA terms into French whereas the lexical approach produced a translation of 3,129 FMA terms into French. A qualitative evaluation was made on 100 FMA terms translated by each method. For the UMLS-based approach, among the 100 translations, 52% were manually rated as "very good" and only 7% translations as "bad". For the lexical approach, among the 100 translations, 47% were rated as "very good" and 20% translations as "bad". Conclusions Overall, a low rate of translations were demonstrated by the two methods. The two approaches permitted us to semi-automatically translate 3,776 FMA terms from English into French, this was to added to the existing 10,844 French FMA terms in the HMTP (4,436 FMA French terms and 6,408 FMA terms manually translated.

  14. Large Prospective Study of Ovarian Cancer Screening in High-risk Women: CA125 Cut-point Defined by Menopausal Status

    Science.gov (United States)

    Skates, Steven J.; Mai, Phuong; Horick, Nora K.; Piedmonte, Marion; Drescher, Charles W.; Isaacs, Claudine; Armstrong, Deborah K.; Buys, Saundra S.; Rodriguez, Gustavo C.; Horowitz, Ira R.; Berchuck, Andrew; Daly, Mary B.; Domchek, Susan; Cohn, David E.; Van Le, Linda; Schorge, John O.; Newland, William; Davidson, Susan A.; Barnes, Mack; Brewster, Wendy; Azodi, Masoud; Nerenstone, Stacy; Kauff, Noah D.; Fabian, Carol J.; Sluss, Patrick M.; Nayfield, Susan G.; Kasten, Carol H.; Finkelstein, Dianne M.; Greene, Mark H.; Lu, Karen

    2011-01-01

    Background Previous screening trials for early detection of ovarian cancer in postmenopausal women have used the standard CA125 cut-point of 35 U/mL, the 98th percentile in this population yielding a 2% false positive rate, while the same cut-point in trials of premenopausal women results in substantially higher false positive rates. We investigated demographic and clinical factors predicting CA125 distributions, including 98th percentiles, in a large population of high-risk women participating in two ovarian cancer screening studies with common eligibility criteria and screening protocols. Methods Baseline CA125 values and clinical and demographic data from 3,692 women participating in screening studies conducted by the NCI-sponsored Cancer Genetics Network and Gynecologic Oncology Group were combined for this pre-planned analysis. Due to the large effect of menopausal status on CA125 levels, statistical analyses were conducted separately in pre- and postmenopausal subjects to determine the impact of other baseline factors on predicted CA125 cut-points based on the 98th percentile. Results The primary clinical factor affecting CA125 cut-points was menopausal status, with premenopausal women having a significantly higher cut-point of 50 U/mL while in postmenopausal subjects the standard cut-point of 35 U/mL was recapitulated. In premenopausal women, current oral contraceptive (OC) users had a cut-point of 40 U/mL. Conclusions To achieve a 2% false positive rate in ovarian cancer screening trials and in high-risk women choosing to be screened, the cut-point for initial CA125 testing should be personalized primarily for menopausal status (~ 50 for premenopausal women, 40 for premenopausal on OC, 35 for postmenopausal women). PMID:21893500

  15. Chitinase Production by Serratia marcescens GG5

    OpenAIRE

    SINGH, Gursharan; SHARMA, Joginder Ram; HOONDAL, Gurinder Singh

    2008-01-01

    Swollen chitin, flake chitin, powder chitin, and mushroom paste were used as substrates for chitinase production by Serratia marcescens GG5 in submerged fermentation. Enzyme production was 0.3 U/ml when the organism was grown in M9 medium supplemented with 0.5% swollen chitin and 0.5% soluble starch. Scanning electron microscopy revealed that Serratia marcescens GG5 digested the chitin flakes by producing chitinase.

  16. The utility of serum CA-125 in predicting extra-uterine disease in apparent early-stage endometrial cancer.

    Science.gov (United States)

    Nicklin, James; Janda, Monika; Gebski, Val; Jobling, Thomas; Land, Russell; Manolitsas, Tom; McCartney, Anthony; Nascimento, Marcelo; Perrin, Lewis; Baker, Jannah F; Obermair, Andreas

    2012-08-15

    Surgical staging in early-stage uterine cancer is controversial. Preoperative serum CA-125 may be of clinical value in predicting the presence of extra-uterine disease in patients with apparent early-stage endometrial cancer. Between October 6, 2005, and June 17, 2010, 760 patients were enrolled in an international, multicentre, prospective randomized trial (LACE) comparing laparotomy with laparoscopy in the management of endometrial cancer apparently confined to the uterus. Of these, 657 patients with endometrial adenocarcinoma had a preoperative serum CA-125 value recorded. Multiple cross-validation analysis was undertaken to correlate preoperative serum CA-125 with stage of disease (Stage I vs. Stage II+) after surgery. Patients' median preoperative serum CA-125 was 14 U/ml. A cutoff point of 30 U/ml was associated with the smallest misclassification error, and using this cutoff, 98 patients (14.9%) had elevated CA-125 levels. Of those, 36 (36.7%) had evidence of extra-uterine disease. Of the 116 patients (17.7%) with evidence of extra-uterine disease, 31.0% had an elevated CA-125 level. On univariate and multivariable logistic regression analysis, only preoperative CA-125 level, but no other preoperative clinical characteristics were found to be associated with extra-uterine spread of disease. Utilizing a cutoff point of 30 U/ml achieved a sensitivity, specificity, positive predictive value and negative predictive value of 31.0, 88.5, 36.7 and 85.7%, respectively. Elevated CA-125 above 30 U/ml in patients with apparent early-stage disease is a risk factor for the presence of extra-uterine disease and may assist clinicians in the management of patients with clinical Stage I endometrial cancer. Copyright © 2011 UICC.

  17. MODEL-BASED SECURITY ENGINEERING OF SOA SYSTEM USING SECURITY INTENT DSL

    OpenAIRE

    Muhammad Qaiser Saleem; Jafreezal Jaafar; Mohd Fadzil Hassan

    2011-01-01

    Currently most of the enterprises are using SOA and web services technologies to build their web information system. They are using MDA principles for design and development of WIS and using UML as a modelling language for business process modelling. Along with the increased connectivity in SOA environment, security risks rise exponentially. Security is not defined during the early phases of development and left onto developer. Properly configuring security requirements in SOA applications is...

  18. Extending Profiles with Stereotypes for Composite Concepts

    OpenAIRE

    Quartel, Dick; Dijkman, R.M.; van Sinderen, Marten J.; Briand, L.; Williams, C.

    2005-01-01

    This paper proposes an extension of the UML 2.0 profiling mechanism. This extension facilitates a language designer to introduce composite concepts as separate conceptual and notational elements in a modelling language. Composite concepts are compositions of existing concepts. To facilitate the introduction of composite concepts, the notion of stereotype is extended. This extension defines how a composite concept can be specified and added to a language’s metamodel, ithout modifying the exist...

  19. Differential regulation of ANG2 and VEGF-A in human granulosa lutein cells by choriogonadotropin.

    Science.gov (United States)

    Pietrowski, D; Keck, C

    2004-04-01

    The growth and development of the corpus luteum after rupture of the follicle is a highly regulated process characterised by a rapid vascularization of the follicle surrounding granulosa cells. Vascularization is regulated by a large number of growth factors and cytokines whereas members of the angiopoietin family and VEGF-A are reported to play a principal role. The gonadotropic hormones luteinizing hormone and choriogonadotropin are reported to be essential for corpus luteum formation. In this study we investigated by RT PCR if the growth factors PGF, PDGF-A, PDGF-B, VEGF-A, VEGF-B, VEGF-C, VEGF-D, ANG1, ANG2, ANG3 and ANG4 are expressed in granulosa cells. We show the expression of VEGF-A, VEGF-B, PDGF-A, ANG1 and ANG2 in granulosa cells. Using RT-PCR and Real-Time PCR we demonstrate that angiopoietin 2 is downregulated in human granulosa cells in vitro after choriogonadotropin treatment whereas the expression of angiopoietin 1 is not significantly altered. The expression of VEGF on the RNA- and on the protein level was determined. It was shown that in granulosa cells VEGF is upregulated after choriogonadotropin treatment on the RNA level and that increasing concentrations of choriogonadotropin from 0 to 10 U/ml leads to an increasing amount of VEGF in the cell culture supernatants. The amount of VEGF in the supernatants reaches a plateau at 0.5 U/ml and is increased only slightly and not significantly after treatment of the cells with 10 U/ml choriogonadotropin compared to 0.5 U/ml. In total these findings suggests that in granulosa cells the mRNA of various growth factors is detectable by RT-PCR and that VEGF-A and ANG2 is regulated by the gonadotropic hormone choriogonadotropin. These findings may add impact on the hypothesis of choriogonadotropin as a novel angiogenic factor.

  20. The Effects of a Sanquinarine Mouthrinse after Periodontal Surgery.

    Science.gov (United States)

    1987-01-01

    resorption . The parathyroid stimulated bone resorption can be inhibited by 20 uM/L of sanguinarine. Therefore, the concentra- tion of sanguinarine...retained in dental plaque may inhibit bone resorption (Sakamoto, 1986). The inhibition of plaque formation by sanguinarine may be due to inhibition of...effect. Viadent incorporates both sanguinarine and zinc in its fornulation. Patients undergoing orthodontic treatment may have a higher than normal

  1. Screening of thermotolerant microorganisms and application for oil separation from palm oil mill wastewater

    Directory of Open Access Journals (Sweden)

    Aran H-Kittikun

    2007-05-01

    Full Text Available The characteristics of palm oil mill wastewater (POMW were brown color, pH 3.8-4.3, temperature 48-55oC, total solids 68.2-82.1 g/l, suspended solids 26.2-65.6 g/l, oil and grease 19.1-25.1 g/l, COD 49.9-160.7g/l and BOD 32.5-75.3 g/l. After centrifugation (3,184 xg of 50 ml POMW for 10 min, the POMW was separated into 3 layers: top (oil, middle (supernatant and bottom layer (sediment. The sediment containeddry weight 1.19 g and oil and grease 1.07 g. In order to release oil and grease trapped in palm fiber debris in the POMW, cellulase- and/or xylanase-enzyme-producing and thermotolerant microorganisms wereisolated. The isolates SO1 and SO2 were isolated from soil near the first anaerobic pond of the palm oil mill. They were aerobic, Gram positive, rod shaped, thermotolerant microorganisms and produced cellulase 12.11 U/ml (3 days and 7.2 U/ml (4 days, and xylanase 50.98 U/ml (4 days and 20.42 U/ml (4 days, respectivelyin synthetic medium containing carboxymethycellulose as a carbon source. When these 2 isolates were added into the steriled POMW under shaking condition for 7 days, after centrifugation at 3,184 xg the isolate SO1gave the better % reduction of dry weight (64.66 % and of oil and grease in the bottom layer (85.32 % of the POMW.

  2. Statistical Optimization of Tannase Production by Penicillium sp. EZ-ZH390 in Submerged Fermentation

    OpenAIRE

    Zohreh Hamidi-Esfahani; Mohammad Ali Sahari; Mohammad Hossein Azizi

    2015-01-01

    Tannase has several important applications in food, feed, chemical and pharmaceutical industries. In the present study, production of tannase by mutant strain, Penicillium sp. EZ-ZH390, was optimized in submerged fermentation utilizing two statistical approaches. At first step, a one factor at a time design was employed to screen the preferable nutriments (carbon and nitrogen sources of the medium) to produce tannase. Screening of the carbon source resulted in the production of 10.74 U/mL of ...

  3. Enhancing Formal Modelling Tool Support with Increased Automation

    DEFF Research Database (Denmark)

    Lausdahl, Kenneth

    Progress report for the qualification exam report for PhD Student Kenneth Lausdahl. Initial work on enhancing tool support for the formal method VDM and the concept of unifying a abstract syntax tree with the ability for isolated extensions is described. The tool support includes a connection to ...... to UML and a test automation principle based on traces written as a kind of regular expressions....

  4. WorkflowNet2BPEL4WS: A Tool for Translating Unstructured Workflow Processes to Readable BPEL

    DEFF Research Database (Denmark)

    Lassen, Kristian Bisgaard; van der Aalst, Wil M. P.

    2007-01-01

    code and not easy to use by end-users. Therefore, we provide a mapping from WF-nets to BPEL. This mapping builds on the rich theory of Petri nets and can also be used to map other languages (e.g., UML, EPC, BPMN, etc.) onto BPEL. To evaluate WorkflowNet2BPEL4WS we used more than 100 processes modeled...

  5. A temperature-controlled cell for X-ray study of liquid systems using a commercial DRON-UM1 diffractometer

    International Nuclear Information System (INIS)

    Petrun'kin, S.P.; Garavina, E.V.; Trostin, V.N.

    1995-01-01

    A container (cell) and a temperature-control system have been designed enabling one to carry out x-ray diffraction study of liquid samples both at a fixed temperature and within a certain temperature range using a commercial DRON-UMl x-ray diffractometer. Special features of the cell and the materials used for it allow one to study both chemically inert and corrosive liquids

  6. Platelets as Contractile Nanomachines for Targeting Drug Delivery in Hemostasis and Thrombosis

    Science.gov (United States)

    2015-12-01

    capsules were suspended in platelet - rich plasma, which was subsequently exposed to 1 U/mL of thrombin, the capsules successfully targeted target...thrombotic sites via integration into the forming fibrin networks and binding to activated platelets . The delivery vehicles successfully adhere to platelet ...rupture has successfully been achieved in static fibrin gels comprised of a high concentration of platelets (Figure 3). Only capsules incorporated into

  7. Sustainable, Green Vinyl Ester Resin (VER) from Renewable Resources

    Science.gov (United States)

    2017-04-02

    subjected to fluctuating prices and limitations in supply . In addition, the synthetic route uses epichlorohydrin as one of the precursors, which is...Figure 6. Procured supercritical- water lignin hydrolysis instrument at UML .............................. 10 Figure 7. FVP design infographic over the...between layers of porous flow media. .................... 148 Figure 153. 11.28 in Hg of vacuum was applied and the bag was inspected for leaks

  8. Processing of poultry feathers by alkaline keratin hydrolyzing enzyme from Serratia sp. HPC 1383.

    Science.gov (United States)

    Khardenavis, Anshuman A; Kapley, Atya; Purohit, Hemant J

    2009-04-01

    The present study describes the production and characterization of a feather hydrolyzing enzyme by Serratia sp. HPC 1383 isolated from tannery sludge, which was identified by the ability to form clear zones around colonies on milk agar plates. The proteolytic activity was expressed in terms of the micromoles of tyrosine released from substrate casein per ml per min (U/mL min). Induction of the inoculum with protein was essential to stimulate higher activity of the enzyme, with 0.03% feathermeal in the inoculum resulting in increased enzyme activity (45U/mL) that further increased to 90U/mL when 3d old inoculum was used. The highest enzyme activity, 130U/mL, was observed in the presence of 0.2% yeast extract. The optimum assay temperature and pH for the enzyme were found to be 60 degrees C and 10.0, respectively. The enzyme had a half-life of 10min at 60 degrees C, which improved slightly to 18min in presence of 1mM Ca(2+). Inhibition of the enzyme by phenylmethyl sulfonyl fluoride (PMSF) indicated that the enzyme was a serine protease. The enzyme was also partially inhibited (39%) by the reducing agent beta-mercaptoethanol and by divalent metal ions such as Zn(2+) (41% inhibition). However, Ca(2+) and Fe(2+) resulted in increases in enzyme activity of 15% and 26%, respectively. The kinetic constants of the keratinase were found to be 3.84 microM (K(m)) and 108.7 microM/mLmin (V(max)). These results suggest that this extracellular keratinase may be a useful alternative and eco-friendly route for handling the abundant amount of waste feathers or for applications in other industrial processes.

  9. The presence of anti-endomysial antibodies and the level of anti-tissue transglutaminases can be used to diagnose adult coeliac disease without duodenal biopsy.

    Science.gov (United States)

    Tortora, R; Imperatore, N; Capone, P; De Palma, G D; De Stefano, G; Gerbino, N; Caporaso, N; Rispo, A

    2014-11-01

    The new ESPGHAN guidelines for diagnosis of paediatric coeliac disease suggest to avoid biopsy in genetically pre-disposed and symptomatic individuals with positive anti-endomysial antibodies (EMA) and anti-tissue transglutaminases (a-tTG). However, duodenal biopsy remains the gold standard in adult coeliac disease. To establish the cut-off values of a-tTG, which would: predict the presence of duodenal histology (Marsh ≥2) diagnostic for coeliac disease; and predict the presence of villous atrophy (Marsh 3) in adults. We performed an observational prospective study including all consecutive adult patients with suspected coeliac disease. All subjects were tested for EMA and a-tTG. Coeliac disease diagnosis was made in presence of Marsh ≥2, a-tTG >7 U/mL and positive EMA. A ROC curve was constructed to establish the best specificity cut-off of a-tTG levels, which would predict the presence of Marsh ≥2 and Marsh 3 at histology. The study included 310 patients with positive antibodies. Histology showed Marsh 1 in 8.7%, Marsh 2 in 3.5%, Marsh 3 in 87.7%. The best cut-off value of a-tTG for predicting Marsh ≥2 was 45 U/mL (sensitivity 70%; specificity 100%; PPV 100%; NPV 24.1%); the best cut-off for predicting villous atrophy was 62.4 U/mL (sensitivity 69%, specificity 100%; PPV 100%; NPV 31%). The diagnosis of coeliac disease can be reached without histology in adult patients with positive EMA and a-tTG levels >45 U/mL. An a-tTG level >62.4 was diagnostic for villous atrophy. These results could contribute to improving the diagnosis of coeliac disease by allowing for a significant reduction in diagnosis-related costs. © 2014 John Wiley & Sons Ltd.

  10. Modelling of Signal - Level Crossing System

    Directory of Open Access Journals (Sweden)

    Daniel Novak

    2006-01-01

    Full Text Available The author presents an object-oriented model of a railway level-crossing system created for the purpose of functional requirements specification. Unified Modelling Language (UML, version 1.4, which enables specification, visualisation, construction and documentation of software system artefacts, was used. The main attention was paid to analysis and design phases. The former phase resulted in creation of use case diagrams and sequential diagrams, the latter in creation of class/object diagrams and statechart diagrams.

  11. SELEKSI DAN IDENTIFIKASI BAKTERI ENDOFIT POTENSIAL PENGHASIL ENZIM PROTEASE DARI TAMAN NASIONAL GUNUNG HALIMUN - (The Selection and Identification of Potential Endophyte Bacteria as Protease Enzyme Producer from Halimun Mount National Park

    Directory of Open Access Journals (Sweden)

    Ruth Melliawati

    2016-12-01

    Full Text Available Endophytic bacteria have an equal chance to bacteria that live outside the plant tissue as potential bacteria. The selection has done towards 326 bacterial endophyte isolates. This research aimed to find and identify proteolytic potential isolates. The proteolytic selection of endophytic bacteria had done using solid skim milk. The capability of endophytic bacteria to agglomerate milk was tested using liquid skim milk which incubated for 7 days at room temperature. Enzyme production of four selected isolates was made through fermentation in GYS medium. The results showed that 86 isolates have proteolytic potential. Isolate HL.29B.63 had highest protease enzymes activity (65.918 U/mL. Medium optimization was able to increase the enzyme activity into 89.94% (125.04 U/mL. The analysis used 16s rDNA showed that isolate HL.29B.63 was Bacillus amyloliquefacient subs. plantarum strain FZB42.Keywords: endophytic bacteria, fermentation, identification, protease, selection ABSTRAKBakteri endofit mempunyai peluang yang sama dengan bakteri yang hidup diluar jaringan tanaman sebagai bakteri potensial. Seleksi dilakukan terhadap 326 isolat bakteri endofit. Tujuan penelitian ini adalah mencari isolat yang berpotensi proteolitik dan mengidentifikasinya. Seleksi proteolitik terhadap bakteri endofitik menggunakan skim milk padat. Uji kemampuan bakteri endofitik dalam menggumpalkan susu menggunakan medium skim milk cair yang diinkubasi selama 7 hari pada suhu ruang. Produksi enzim terhadap empat isolat terseleksi dilakukan melalui fermentasi dalam medium GYS. Hasilnya menunjukkan bahwa 86 isolat mempunyai potensi proteolitik. Isolat HL.29B.63 mempunyai aktif enzim protease tertinggi (65,918 U/mL. Optimasi medium dapat meningkatkan aktivitas enzim sebesar 89,94% (125,04 U/mL. Analisis menggunakan 16s rDNA menunjukkan bahwa isolat HL.29B.63 adalah Bacillus amyloliquefaciens subs. plantarum strain FZB42.Kata kunci: bakteri endofit, fermentasi, identifikasi, protease

  12. Translating Unstructured Workflow Processes to Readable BPEL: Theory and Implementation

    DEFF Research Database (Denmark)

    van der Aalst, Willibrordus Martinus Pancratius; Lassen, Kristian Bisgaard

    2008-01-01

    and not easy to use by end-users. Therefore, we provide a mapping from Workflow Nets (WF-nets) to BPEL. This mapping builds on the rich theory of Petri nets and can also be used to map other languages (e.g., UML, EPC, BPMN, etc.) onto BPEL. In addition to this we have implemented the algorithm in a tool called...... WorkflowNet2BPEL4WS....

  13. Optimization and scale-up of fermentation of glucansucrase and branched glucan by Pediococcus pentosaceus CRAG3 using Taguchi methodology in bioreactor

    Directory of Open Access Journals (Sweden)

    RISHIKESH SHUKLA

    2012-01-01

    Full Text Available The present investigation focuses on screening and optimization of media components to enhance glucansucrase and glucan production by Pediococcus pentosaceus CRAG3 at shake-flask and bioreactor level using Taguchi orthogonal array design. A three-level Taguchi orthogonal array layout of L27 (33 was employed, in which six variables were studied for their influence on glucansucrase and glucan production. The results showed that sucrose, K2HPO4 and Tween-80 were the most significant factors to improve glucansucrase production while the glucan production was mostly affected by sucrose, peptone and K2HPO4. The optimized medium composition for maximum glucansucrase and glucan production were: sucrose 3.5% and 5%; yeast extract 0.2% and 2.0%; beef extract 0.5% and 0.5%; peptone 3.0% and 1.0%; K2HPO4 0.2% and 0.2%, and Tween-80 1.0 and 0.1%, respectively. The optimized medium gave 10.1 U/ml and 10.2 U/ml glucansucrase activity while glucan concentrations were 56 mg/ml and 80 mg/ml in shake flask and bioreactor level, respectively which were in good agreement with predicted values (10.1 U/ml and 54.5 mg/ml. The optimized medium gave 2 fold enhancement in enzyme activity and 4 fold increase in glucan concentration as compared to non-optimized medium (4.5 U/ml and 15 mg/ml, respectively at shake flask level.

  14. Using ontology-based semantic similarity to facilitate the article screening process for systematic reviews.

    Science.gov (United States)

    Ji, Xiaonan; Ritter, Alan; Yen, Po-Yin

    2017-05-01

    Systematic Reviews (SRs) are utilized to summarize evidence from high quality studies and are considered the preferred source of evidence-based practice (EBP). However, conducting SRs can be time and labor intensive due to the high cost of article screening. In previous studies, we demonstrated utilizing established (lexical) article relationships to facilitate the identification of relevant articles in an efficient and effective manner. Here we propose to enhance article relationships with background semantic knowledge derived from Unified Medical Language System (UMLS) concepts and ontologies. We developed a pipelined semantic concepts representation process to represent articles from an SR into an optimized and enriched semantic space of UMLS concepts. Throughout the process, we leveraged concepts and concept relations encoded in biomedical ontologies (SNOMED-CT and MeSH) within the UMLS framework to prompt concept features of each article. Article relationships (similarities) were established and represented as a semantic article network, which was readily applied to assist with the article screening process. We incorporated the concept of active learning to simulate an interactive article recommendation process, and evaluated the performance on 15 completed SRs. We used work saved over sampling at 95% recall (WSS95) as the performance measure. We compared the WSS95 performance of our ontology-based semantic approach to existing lexical feature approaches and corpus-based semantic approaches, and found that we had better WSS95 in most SRs. We also had the highest average WSS95 of 43.81% and the highest total WSS95 of 657.18%. We demonstrated using ontology-based semantics to facilitate the identification of relevant articles for SRs. Effective concepts and concept relations derived from UMLS ontologies can be utilized to establish article semantic relationships. Our approach provided a promising performance and can easily apply to any SR topics in the

  15. PRODUCTION OF FIBRINOLYTIC ENZYME (NATTOKINASE) FROM BACILLUS SP.

    OpenAIRE

    Padma Singh, Rekha Negi*, Vani Sharma, Alka Rani, Pallavi and Richa Prasad

    2018-01-01

    During present study Nattokinase which is a novel fibrinolytic enzyme was produced by Bacillus sp. To screen and extract nattokinase enzyme from Bacillus sp. were isolated from soil of different agricultural field by serial dilution method. Out of 10 isolate, one strain i.e. B3 produced nattokinase on screening medium. B3 was identified by biochemical characterization. The caseinolytic activity of Nattokinase was 0.526 U/ml and the selected isolate Bacillus sp. could produce active nattokinas...

  16. Nattokinase production: Medium components and feeding strategy studies

    OpenAIRE

    Berenjian Aydin; Mahanama Raja; Kavanagh John; Dehghani Fariba; Ghasemi Younes

    2014-01-01

    In the present study, the effect of nutrients on nattokinase activity during the fermentation of Bacillus subtilis natto was investigated. The highest nattokinase activity of 587 U/mL was obtained in fermenter for a media consisting of yeast extract (6%, w/v), soy peptone (1.2%, w/v) and glycerol (6%, w/v). The second order polynomial equation was fitted to the results by using central composite face design. The polynomial model fitted the experimental data...

  17. Influence of gamma rays radiation on lignin degradation potency of phanerochaete chrysosporium and ganoderma lucidum

    International Nuclear Information System (INIS)

    Tri Retno DL; Nana Mulyana; Nurhasni; Uswatun Hasanah

    2016-01-01

    This research aims to increase the activity of extracellular enzymes lignolitik fungi phanerochaete chrysosporium and ganoderma lucidum to degrade lignocellulosic waste. Lignocellulosic difficult to degrade because it is composed of lignin, cellulose and hemicellulose. Phanerochaete chrysosporium and ganoderma lucidum group white rot fungi can degrade lignin because it is able to synthesize enzymes lignin peroxidase (LiP). Irradiation low dose gamma rays capable menstimulsi increase extracellular enzyme activity. Fungi phanerochaete chrysosporium and ganoderma lucidum in medium slent exposed to gamma irradiation at doses of 0 (control), 200, 400, 600, 800 and 1000 Gy. In a liquid medium containing Potatoes Dextrose Broth (PDB), mineral salts with the substrate lignin alkali 0 and 5 % w/v, fungi phanerochaete chrysosporium were exposed to a dose of 600 Gy of gamma rays have LiP activity (30 U/mL) by 2.5 times higher compared with controls (12 U/mL). While ganoderma lucidum that are exposed to gamma radiation at a dose of 800 Gy has LiP activity (34 U/mL) was 1.7 times higher than the control (20 U/mL). On a solid substrate fermentation of white teak powder (Gmelina arborea Roxb.) For 12 days at pH 6.4 and water content of 79 % by fungi phanerochaete chrysosporium were exposed to gamma ray dose of 600 Gy has an efficiency of lignin degradation by 42 %, whereas on fungi ganoderma lucidum that are exposed gamma ray dose of 800 Gy has an efficiency of lignin degradation by 21 % with optimal conditions of pH 7. And; water content of 71.3 %. (author)

  18. Quantitative thyroid scintigraphy for the differentiation of Graves' disease and hyperthyroid autoimmune thyroiditis

    Energy Technology Data Exchange (ETDEWEB)

    Sahlmann, C.O.; Siefker, U.; Lehmann, K.; Harms, E.; Conrad, M.; Meller, J. [Goettingen Univ. (Germany). Abt. fuer Nuklearmedizin

    2004-08-01

    The purpose of this study is the evaluation of the TCTUs in the differentiation between AIT and GD in patients with hyperthyroidism. Methods: We determined the TCTUs in 59 patients with untreated hyperthyroid GD and in 51 patients with AIT who had subclinical or manifest hyperthyroidism without medication. Patients with GD were characterized by the presence of hyperthyroidism, decreased echogenicity of the thyroid, elevation of TSH-receptor autoantibodies (TRAb). AIT was defined by a decreased echogenicity of the thyroid, absence of elevated TSH-receptor autoantibodies (TRAb), autoantibodies against the thyroid peroxidase (anti-TPO) and spontaneous remission or development of subclinical hypothyroidism within 3 months. Results: Thyroid volumes of patients with AIT were significantly lower than those of patients with GD (p<0.05). TRAb levels were significantly higher in GD-patients (median: 19.5 U/ml; range: 15.3-35 U/ml) than in AIT-patients (median: 1.3 U/ml; range: 0-4.1 U/ml). 73% (38/59) of patients with GD had elevated anti-TPO levels. In these patients anti-TPO levels (median: 768 U/l; range: 83-6397 U/l) were not significantly different from anti-TPO levels of patients with AIT (median: 834 U/l; range: 107-8675 U/l; p=0.17). TCTUs values of patients with AIT were significantly lower (p<0.05; median: 0.9%; range: 0.1-3.2%) than those of patients with GD (median: 5.7%; range: 1.9-28.3%). Conclusion: In our patients quantitative thyroid scintigraphy with {sup 99m}TcO{sub 4}{sup -} offered rapid and reliable differentiation between hyperthyroid GD and AIT. (orig.)

  19. Stable SU(5) monopoles with higher magnetic charge

    International Nuclear Information System (INIS)

    Miyamoto, S.; Sato, H.; Tomohiro, S.

    1985-01-01

    Taking into account the electroweak breaking effects, some multiply charged monopoles were shown to be stable by Gardner and Harvey. We give the explicit Ansa$uml: tze for finite-energy, nonsingular solutions of these stable higher-strength monopoles with eg = 1,(3/2),3. We also give the general stability conditions and the detailed behavior of the interaction potentials between two monopoles which produce the stable higher-strength monopoles

  20. Design and Development of a Web Based User Interface

    OpenAIRE

    László, Magda

    2014-01-01

    The first objective of the thesis is to study the technological background of application design and more specifically the Unified Modeling Language (hereinafter UML). Due to this, the research provides deeper understanding of technical aspects of the practical part of the thesis work. The second and third objectives of this thesis are to design and develop a web application and more specifically a Web Based User Interface for Multimodal Observation and Analysis System for Social Interactions...